PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2532482-0 1989 Aldosterone and renin inhibition by atrial natriuretic factor in potassium-loaded rats. Potassium 65-74 renin Rattus norvegicus 16-21 2698930-1 1989 Hydroxy-ethylene dipeptide analogues (Leu[CH(OH)-CH2]Leu and Leu[CH(OH)-CH2]Val) of human substrate peptides are potent in vitro inhibitors of rat renin with IC50 values as low as 0.8 nmol/l. hydroxy-ethylene dipeptide 0-26 renin Rattus norvegicus 147-152 2511053-9 1989 When the effects of the renin-angiotensin system were excluded by bilateral nephrectomy, indomethacin caused a significant increase (P less than .05) in vascular resistance. Indomethacin 89-101 renin Rattus norvegicus 24-29 2690648-1 1989 The vasopressin-mediated recovery of arterial pressure observed in adult rats following pharmacological blockade of the sympathetic nervous and renin-angiotensin systems is reduced by neonatal capsaicin treatment. Capsaicin 193-202 renin Rattus norvegicus 144-149 2692455-3 1989 In a superfusion system of dispersed rat renal cortical cells, 10(-10) M endothelin inhibited renin release stimulated by 5 x 10(-8) M isoproterenol or 5 x 10(-5) M 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8, a putative intracellular Ca antagonist). Isoproterenol 135-148 renin Rattus norvegicus 94-99 2692455-4 1989 Endothelin showed a slight but significant inhibitory effect on renin release stimulated by isoproterenol or TMB-8 even in the absence of extracellular Ca. Isoproterenol 92-105 renin Rattus norvegicus 64-69 2692455-4 1989 Endothelin showed a slight but significant inhibitory effect on renin release stimulated by isoproterenol or TMB-8 even in the absence of extracellular Ca. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 109-114 renin Rattus norvegicus 64-69 2692455-5 1989 Endothelin also inhibited renin release in the presence of 10(-4) M nicardipine. Nicardipine 68-79 renin Rattus norvegicus 26-31 2692455-6 1989 In a superfusion system of renal cortical slices, both 10(-8) M endothelin and a high concentration (60 mM) of K inhibited renin release, and 10(-6) M nicardipine attenuated the inhibition of renin release by high K but did not affect the inhibition by endothelin. Nicardipine 151-162 renin Rattus norvegicus 192-197 2698933-3 1989 Rats treated with 0.3 mg nitrofurantoin showed a 50% decrease in glutathione reductase activity with a twofold increase in the ratio of glutathione disulphide to reduced glutathione in the hypothalamus and brainstem, and a 1.5-fold increase in plasma noradrenaline and plasma renin activity compared with controls. Nitrofurantoin 25-39 renin Rattus norvegicus 276-281 2698938-4 1989 The calcium channel antagonist nimodipine (2 mumol/l) completely blocks the vasoconstrictor and renin secretion response of a median inhibitory concentration (IC50) of endothelin, indicating that entry of external calcium may play a role. Nimodipine 31-41 renin Rattus norvegicus 96-101 2698938-4 1989 The calcium channel antagonist nimodipine (2 mumol/l) completely blocks the vasoconstrictor and renin secretion response of a median inhibitory concentration (IC50) of endothelin, indicating that entry of external calcium may play a role. Calcium 4-11 renin Rattus norvegicus 96-101 2698938-5 1989 Vasoconstriction and inhibition of renin release by endothelin are attenuated in the presence of a protein kinase C inhibitor, staurosporine, which suggests that protein kinase C helps to mediate the effects of endothelin on renin secretion and vascular resistance. Staurosporine 127-140 renin Rattus norvegicus 35-40 2698938-5 1989 Vasoconstriction and inhibition of renin release by endothelin are attenuated in the presence of a protein kinase C inhibitor, staurosporine, which suggests that protein kinase C helps to mediate the effects of endothelin on renin secretion and vascular resistance. Staurosporine 127-140 renin Rattus norvegicus 225-230 2553918-2 1989 RU 24969, a 5-HT agonist with highest affinity at 5-HT1A and 5-HT1B receptors, increased plasma renin activity (PRA) and plasma renin concentration (PRC) as well as plasma corticosterone and prolactin concentrations in a dose-dependent manner. 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole 0-8 renin Rattus norvegicus 96-101 2686465-3 1989 Fetal, newborn, and adult kidney tissue sections from Wistar-Kyoto rats were hybridized with an oligonucleotide complementary to rat renin mRNA. Oligonucleotides 96-111 renin Rattus norvegicus 133-138 2699355-4 1989 (3) Pharmacological blockade of the renin-angiotensin-system with captopril induced a more pronounced hypotonia in capsaicin-pretreated than in control rats. Captopril 66-75 renin Rattus norvegicus 36-41 2699355-4 1989 (3) Pharmacological blockade of the renin-angiotensin-system with captopril induced a more pronounced hypotonia in capsaicin-pretreated than in control rats. Capsaicin 115-124 renin Rattus norvegicus 36-41 2699355-6 1989 (4) Plasma renin activity was increased by a factor of 2 following guanethidine treatment of awake animals. Guanethidine 67-79 renin Rattus norvegicus 11-16 2553918-2 1989 RU 24969, a 5-HT agonist with highest affinity at 5-HT1A and 5-HT1B receptors, increased plasma renin activity (PRA) and plasma renin concentration (PRC) as well as plasma corticosterone and prolactin concentrations in a dose-dependent manner. 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole 0-8 renin Rattus norvegicus 128-133 2507288-0 1989 A 12-lipoxygenase product of arachidonate metabolism is involved in angiotensin action on renin release. Arachidonic Acid 29-41 renin Rattus norvegicus 90-95 2508488-0 1989 Modulation of renin by thromboxane: studies with thromboxane synthase inhibitor, receptor antagonists, and mimetic. Thromboxanes 23-34 renin Rattus norvegicus 14-19 2552916-0 1989 Effects of inhibitors of the renin-angiotensin system on water intake after insulin administration. Water 57-62 renin Rattus norvegicus 29-34 2682342-5 1989 These results suggest that reduced salt intake in response to manipulations of the body sodium and renin-angiotensin system in hypophysectomized rats may result from decreased angiotensinogen mRNA levels. Salts 35-39 renin Rattus norvegicus 99-104 2507288-2 1989 Since 12-HETE is not only a major arachidonate lipoxygenase (LO) product in the kidney, but is also a potent inhibitor of renin release, we studied the role of AII on renin inhibition and 12-HETE formation using rat renal cortical slices and isolated juxtaglomerular-like cells. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 6-13 renin Rattus norvegicus 122-127 2677316-0 1989 Caffeine potentiates the renin response to furosemide in rats. Caffeine 0-8 renin Rattus norvegicus 25-30 2677316-0 1989 Caffeine potentiates the renin response to furosemide in rats. Furosemide 43-53 renin Rattus norvegicus 25-30 2677316-2 1989 Adenosine is a potent inhibitor of renin release. Adenosine 0-9 renin Rattus norvegicus 35-40 2677316-3 1989 It has therefore been suggested that endogenous adenosine may play a role in the regulation of renin release. Adenosine 48-57 renin Rattus norvegicus 95-100 2677316-5 1989 Evidence to support a modulatory role of adenosine on renin release in vivo is, however, limited. Adenosine 41-50 renin Rattus norvegicus 54-59 2677316-6 1989 We therefore wanted to determine if: 1) adenosine modulates furosemide-induced renin release and 2) sodium-chloride reabsorption at the macula densa is essential for adenosine actions. Furosemide 60-70 renin Rattus norvegicus 79-84 2677316-9 1989 In the vehicle group, furosemide increased urinary volume, sodium and potassium excretion and increased plasma renin activity from 6 +/- 1 to 45 +/- 11 ngAl/ml/hr. Furosemide 22-32 renin Rattus norvegicus 111-116 2677316-10 1989 Caffeine and 1,3-dipropyl-8-(p-sulfophenyl)xanthine potentiated the increase in plasma renin activity produced by furosemide (to 120 +/- 15 and 147 +/- 21 ng Al/ml/hr, respectively), whereas having no significant effects on urinary volume, sodium excretion or blood pressure. Caffeine 0-8 renin Rattus norvegicus 87-92 2677316-10 1989 Caffeine and 1,3-dipropyl-8-(p-sulfophenyl)xanthine potentiated the increase in plasma renin activity produced by furosemide (to 120 +/- 15 and 147 +/- 21 ng Al/ml/hr, respectively), whereas having no significant effects on urinary volume, sodium excretion or blood pressure. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 13-51 renin Rattus norvegicus 87-92 2677316-10 1989 Caffeine and 1,3-dipropyl-8-(p-sulfophenyl)xanthine potentiated the increase in plasma renin activity produced by furosemide (to 120 +/- 15 and 147 +/- 21 ng Al/ml/hr, respectively), whereas having no significant effects on urinary volume, sodium excretion or blood pressure. Furosemide 114-124 renin Rattus norvegicus 87-92 2677316-10 1989 Caffeine and 1,3-dipropyl-8-(p-sulfophenyl)xanthine potentiated the increase in plasma renin activity produced by furosemide (to 120 +/- 15 and 147 +/- 21 ng Al/ml/hr, respectively), whereas having no significant effects on urinary volume, sodium excretion or blood pressure. Sodium 240-246 renin Rattus norvegicus 87-92 2677316-11 1989 These results suggest that furosemide-induced renin release in vivo is restrained by endogenous adenosine. Furosemide 27-37 renin Rattus norvegicus 46-51 2677316-11 1989 These results suggest that furosemide-induced renin release in vivo is restrained by endogenous adenosine. Adenosine 96-105 renin Rattus norvegicus 46-51 2812277-2 1989 After 2 weeks of sodium deprivation, the peripheral angiotensin system was activated as shown by increased plasma renin activity (4-fold) and plasma aldosterone concentration (approximately 40-fold). Sodium 17-23 renin Rattus norvegicus 114-119 2553324-14 1989 Effects of low [Ca2+], diltiazem and TMB-8 on renin secretion were all shown to be reversible when superfusion with control buffer was resumed. Diltiazem 23-32 renin Rattus norvegicus 46-51 2553324-14 1989 Effects of low [Ca2+], diltiazem and TMB-8 on renin secretion were all shown to be reversible when superfusion with control buffer was resumed. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 37-42 renin Rattus norvegicus 46-51 2553324-7 1989 The Ca2+ entry blocking drug diltiazem in a range of concentrations increased renin release and at 10(-5) mol/l diltiazem the mean stimulation was 35% (P less than 0.01). Diltiazem 29-38 renin Rattus norvegicus 78-83 2553324-9 1989 8-(N.N-Diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8) reduces the release of Ca2+ from intracellular stores and, studied over a range of concentrations, this compound increased renin release. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 66-71 renin Rattus norvegicus 196-201 2667956-10 1989 The insulin-induced 50% decrease in glucose caused minor effects on arterial blood pressure and heart rate and occasioned responses in renin and norepinephrine of similar magnitudes in the two groups. Glucose 36-43 renin Rattus norvegicus 135-140 2547581-4 1989 In all groups enalapril treatment resulted in a significant (P less than 0.001) reduction in blood pressure, an increase in renin activity, and a reduction in plasma aldosterone when all of the animals were considered together, although the change in blood pressure achieved statistical significance only in the Wistar-Kyoto rats. Enalapril 14-23 renin Rattus norvegicus 124-129 2682521-0 1989 Influence of bicarbonate on the sensitivity of renin release to sodium chloride. Bicarbonates 13-24 renin Rattus norvegicus 47-52 2681590-7 1989 However, short periods of enalapril treatment in young animals attenuate the development of hypertension and normalize hindlimb resistance properties, suggesting that the renin-angiotensin system may have a role in early vascular growth. Enalapril 26-35 renin Rattus norvegicus 171-176 2573495-0 1989 Disposition, metabolism, and excretion of U-71038, a novel renin inhibitor peptide, in the rat. ditekiren 42-49 renin Rattus norvegicus 59-64 2573495-1 1989 The in vivo fate of U-71038 (Boc-Pro-Phe-N-MeHis-Leu psi [CHOHCH2] Val-Ile-(aminomethyl)pyridine), a potent renin inhibitor, was investigated in rats by single iv administration of tritium-labeled drug at a dose level of 5 mg/kg. ditekiren 20-27 renin Rattus norvegicus 108-113 2677137-2 1989 The kidney renin mRNA was quantified by densitometric Northern blot analysis using a 32P-labelled rat renin genomic DNA fragment as a hybridization probe. Phosphorus-32 85-88 renin Rattus norvegicus 11-16 2677137-2 1989 The kidney renin mRNA was quantified by densitometric Northern blot analysis using a 32P-labelled rat renin genomic DNA fragment as a hybridization probe. Phosphorus-32 85-88 renin Rattus norvegicus 102-107 2677137-4 1989 Plasma renin activity (PRA) in SHR and WKY was increased similarly by sodium depletion and by treatment with captopril. Sodium 70-76 renin Rattus norvegicus 7-12 2677137-4 1989 Plasma renin activity (PRA) in SHR and WKY was increased similarly by sodium depletion and by treatment with captopril. Captopril 109-118 renin Rattus norvegicus 7-12 2677137-6 1989 Both sodium depletion and captopril treatment caused significant increases in the kidney renin mRNA in SHR and WKY. Sodium 5-11 renin Rattus norvegicus 89-94 2677137-6 1989 Both sodium depletion and captopril treatment caused significant increases in the kidney renin mRNA in SHR and WKY. Captopril 26-35 renin Rattus norvegicus 89-94 2682521-0 1989 Influence of bicarbonate on the sensitivity of renin release to sodium chloride. Sodium Chloride 64-79 renin Rattus norvegicus 47-52 2682521-4 1989 Renin release from time controls superfused with a bicarbonate-free Ringer was identical to release from glomeruli superfused with a bicarbonate Ringer. Bicarbonates 51-62 renin Rattus norvegicus 0-5 2682521-6 1989 30 mM sucrose inhibited renin release independently of bicarbonate. Sucrose 6-13 renin Rattus norvegicus 24-29 2682521-2 1989 The sensitivity of renin release to increases in osmolality by NaCl was therefore tested on superfused rat glomeruli treated with bicarbonate/chloride exchange inhibitor (DNDS), NaCl/KCl cotransport inhibitor (bumetanide), or Na+/H+ antiport inhibitor (amiloride) in the presence or absence of bicarbonate. Sodium Chloride 63-67 renin Rattus norvegicus 19-24 2682521-7 1989 15 mM NaCl stimulated renin release when bicarbonate was absent, while it caused an inhibition in the presence of bicarbonate. Sodium Chloride 6-10 renin Rattus norvegicus 22-27 2764141-1 1989 High dietary intake of linoleic acid lowers arterial pressure, and, in vitro, linoleic acid inhibits the enzymatic activity of renin. Linoleic Acid 23-36 renin Rattus norvegicus 127-132 2682521-7 1989 15 mM NaCl stimulated renin release when bicarbonate was absent, while it caused an inhibition in the presence of bicarbonate. Bicarbonates 41-52 renin Rattus norvegicus 22-27 2682521-8 1989 When bicarbonate/chloride exchange was inhibited, addition of NaCl stimulated renin release even when bicarbonate was present. Bicarbonates 5-16 renin Rattus norvegicus 78-83 2682521-8 1989 When bicarbonate/chloride exchange was inhibited, addition of NaCl stimulated renin release even when bicarbonate was present. Sodium Chloride 62-66 renin Rattus norvegicus 78-83 2682521-9 1989 The effect of NaCl on renin release was not affected by amiloride (1 mM) or bumetanide (10 microM). Sodium Chloride 14-18 renin Rattus norvegicus 22-27 2682521-11 1989 Furthermore, the sensitivity of renin release to changes in NaCl concentrations is modulated by bicarbonate in a way that depends on a functioning anion-exchange mechanism. Sodium Chloride 60-64 renin Rattus norvegicus 32-37 2682521-11 1989 Furthermore, the sensitivity of renin release to changes in NaCl concentrations is modulated by bicarbonate in a way that depends on a functioning anion-exchange mechanism. Bicarbonates 96-107 renin Rattus norvegicus 32-37 2764141-1 1989 High dietary intake of linoleic acid lowers arterial pressure, and, in vitro, linoleic acid inhibits the enzymatic activity of renin. Linoleic Acid 78-91 renin Rattus norvegicus 127-132 2764141-5 1989 In sodium chloride-deprived rats, the reduction of blood pressure by linoleic acid infusion was associated with increased plasma renin activity (P less than 0.05); serum angiotensin-converting enzyme activity was unchanged. Linoleic Acid 69-82 renin Rattus norvegicus 129-134 2764141-8 1989 Thus, although linoleic acid infusion lowered blood pressure in high renin but not in low renin states, the reduction of blood pressure was not related to inhibition of circulating renin or to alterations of endogenous prostaglandin biosynthesis. Linoleic Acid 15-28 renin Rattus norvegicus 69-74 2671515-0 1989 Cranial puncture, a simple procedure requiring no preparatory surgery: validation by observation of drinking and salt appetite evoked by intracerebroventricular renin. Salts 113-117 renin Rattus norvegicus 161-166 2791336-4 1989 Rats receiving the low sodium diet had significantly higher plasma renin activity than rats receiving the high sodium diet. Sodium 23-29 renin Rattus norvegicus 67-72 2671515-5 1989 Renin injections by either procedure evoked copious drinking of water (224 +/- 23 ml/24 h) and 3% NaCl (44 +/- 9.1 ml/24 h) at smaller doses than previously reported. Water 64-69 renin Rattus norvegicus 0-5 2671515-5 1989 Renin injections by either procedure evoked copious drinking of water (224 +/- 23 ml/24 h) and 3% NaCl (44 +/- 9.1 ml/24 h) at smaller doses than previously reported. Sodium Chloride 98-102 renin Rattus norvegicus 0-5 2687518-4 1989 Isolated glomeruli were placed within the superfusion chamber and perfused with Krebs-Ringer solution at a constant flow of 0.3 ml/minute at 37 degrees C. Renin release was increased by calmodulin inhibitor, W-7 in both SHR and WKY. krebs 80-85 renin Rattus norvegicus 155-160 2668075-1 1989 Intracerebroventricular injections of renin in suckling rat pups increased intake of NaCl solutions when they were orally infused 5 hr after injection. nacl solutions 85-99 renin Rattus norvegicus 38-43 2687518-4 1989 Isolated glomeruli were placed within the superfusion chamber and perfused with Krebs-Ringer solution at a constant flow of 0.3 ml/minute at 37 degrees C. Renin release was increased by calmodulin inhibitor, W-7 in both SHR and WKY. W 7 208-211 renin Rattus norvegicus 155-160 2547485-2 1989 Subcutaneous injection of the kappa-opioid agonist U50,488 into conscious, saline-loaded rats was associated with a diuresis, antinatriuresis and antikaliuresis which lasted for up to 3 h. Plasma renin activity and corticosterone levels were elevated but plasma vasopressin (AVP) and aldosterone levels were unaltered in similarly treated rats. u50 51-54 renin Rattus norvegicus 196-201 2544410-7 1989 These findings support the hypothesis that a local adrenal renin system may play a physiological role in the control of adrenal aldosterone production. Aldosterone 128-139 renin Rattus norvegicus 59-64 2510668-0 1989 [Effects of sodium depletion in rats actively immunized against renin]. Sodium 12-18 renin Rattus norvegicus 64-69 2510668-1 1989 The influence of active immunization against renin on systolic blood pressure in response to a dietary sodium restriction was assessed in normotensive rats (WKY) and spontaneously hypertensive rats (SHR). Sodium 103-109 renin Rattus norvegicus 45-50 2510668-11 1989 These results confirm the importance of an efficient renin-angiotensin system in the adaptative response to sodium restriction. Sodium 108-114 renin Rattus norvegicus 53-58 2470583-0 1989 Regulation of adrenal renin messenger ribonucleic acid by dietary sodium chloride. Sodium Chloride 66-81 renin Rattus norvegicus 22-27 2667571-6 1989 Moreover, verapamil (5 X 10(-6) mol/L) blocked the SCT-induced suppression of renin secretion (9.79 +/- 0.44 v 9.36 +/- 1.05 GU/g/h, P = NS). Verapamil 10-19 renin Rattus norvegicus 78-83 2527043-0 1989 Effect of fructose-induced hypertension on the renin-angiotensin-aldosterone system and atrial natriuretic factor. Fructose 10-18 renin Rattus norvegicus 47-52 2660590-0 1989 Modification of glycosylation of renin in sodium-depleted and captopril-treated rats. Sodium 42-48 renin Rattus norvegicus 33-38 2660590-0 1989 Modification of glycosylation of renin in sodium-depleted and captopril-treated rats. Captopril 62-71 renin Rattus norvegicus 33-38 2660590-8 1989 These results show that the predominant release of renin C, with the longest half-life (35 min) in the plasma, contributes to the increased plasma renin concentration in sodium-depleted and captopril-treated rats. Sodium 170-176 renin Rattus norvegicus 51-56 2660590-8 1989 These results show that the predominant release of renin C, with the longest half-life (35 min) in the plasma, contributes to the increased plasma renin concentration in sodium-depleted and captopril-treated rats. Sodium 170-176 renin Rattus norvegicus 147-152 2660590-8 1989 These results show that the predominant release of renin C, with the longest half-life (35 min) in the plasma, contributes to the increased plasma renin concentration in sodium-depleted and captopril-treated rats. Captopril 190-199 renin Rattus norvegicus 51-56 2660590-8 1989 These results show that the predominant release of renin C, with the longest half-life (35 min) in the plasma, contributes to the increased plasma renin concentration in sodium-depleted and captopril-treated rats. Captopril 190-199 renin Rattus norvegicus 147-152 2470583-8 1989 The membranes were freed from the 32P-labeled renin cDNA and subsequently rehybridized with a 32P-radiolabeled 1200-bp beta-actin cDNA probe. Phosphorus-32 34-37 renin Rattus norvegicus 46-51 2661429-2 1989 In sodium-replete rats the infusion of the renin inhibitor CP71362 (100 micrograms/kg/min) decreased blood pressure by 13 +/- 1 mm Hg (p less than 0.0001), reduced plasma renin activity to undetectable levels, but did not lower plasma angiotensin II. Sodium 3-9 renin Rattus norvegicus 43-48 2661430-7 1989 These results indicate that N-acetyl-pepstatin suppresses the vascular renin-angiotensin system. n-acetyl-pepstatin 28-46 renin Rattus norvegicus 71-76 2661429-2 1989 In sodium-replete rats the infusion of the renin inhibitor CP71362 (100 micrograms/kg/min) decreased blood pressure by 13 +/- 1 mm Hg (p less than 0.0001), reduced plasma renin activity to undetectable levels, but did not lower plasma angiotensin II. CP 71362 59-66 renin Rattus norvegicus 43-48 2484080-0 1989 Effect of bopindolol on renin secretion and renal excretory function in rats. bopindolol 10-20 renin Rattus norvegicus 24-29 2661429-2 1989 In sodium-replete rats the infusion of the renin inhibitor CP71362 (100 micrograms/kg/min) decreased blood pressure by 13 +/- 1 mm Hg (p less than 0.0001), reduced plasma renin activity to undetectable levels, but did not lower plasma angiotensin II. CP 71362 59-66 renin Rattus norvegicus 171-176 2484080-1 1989 We investigated the effects of the new beta-adrenoceptor antagonist, bopindolol, on stimulated renin secretion and on renal function in conscious rats. bopindolol 69-79 renin Rattus norvegicus 95-100 2661429-3 1989 In rats treated chronically with enalapril (30 mg/kg/day), CP71362 decreased blood pressure by an additional 5 +/- 2 mm Hg (p less than 0.025) and reduced plasma renin activity and angiotensin II concentrations to undetectable levels. Enalapril 33-42 renin Rattus norvegicus 162-167 2484080-2 1989 Intravenous doses of 10, 31.6, and 100 micrograms/kg of bopindolol antagonized the rise in plasma renin activity (PRA) induced by the administration of isoproterenol (10 micrograms/kg, s.c.). bopindolol 56-66 renin Rattus norvegicus 98-103 2661430-3 1989 Infusion of N-acetyl-pepstatin (5 X 10(-8)-5 X 10(-6) M) suppressed vascular renin activity and Ang II release dose dependently. n-acetyl-pepstatin 12-30 renin Rattus norvegicus 77-82 2484080-2 1989 Intravenous doses of 10, 31.6, and 100 micrograms/kg of bopindolol antagonized the rise in plasma renin activity (PRA) induced by the administration of isoproterenol (10 micrograms/kg, s.c.). Isoproterenol 152-165 renin Rattus norvegicus 98-103 2484080-11 1989 These results indicate that bopindolol (a) is a potent, long-acting, orally active, antagonist of beta-adrenoceptor-stimulated renin secretion in the rat, (b) is ineffective in antagonizing furosemide-induced rise in PRA, (c) does not elevate basal levels of PRA by virtue of its intrinsic sympathomimetic activity, and (d) does not cause dramatic alteration of renal excretory function at effective beta-blocking doses. bopindolol 28-38 renin Rattus norvegicus 127-132 2813487-4 1989 Since beta adrenergic agonists such as isoproterenol are potent releasers of renin, these findings support previous work showing that different kinds of interventions which share the common property of elevating activity in the renin-angiotensin system (beta adrenergic stimulation in the present case) consistently result in the reduction of voluntary alcohol intake. Isoproterenol 39-52 renin Rattus norvegicus 77-82 2813487-4 1989 Since beta adrenergic agonists such as isoproterenol are potent releasers of renin, these findings support previous work showing that different kinds of interventions which share the common property of elevating activity in the renin-angiotensin system (beta adrenergic stimulation in the present case) consistently result in the reduction of voluntary alcohol intake. Isoproterenol 39-52 renin Rattus norvegicus 228-233 2655664-8 1989 Infusion of renin form 4 increased urine volume and sodium excretion significantly. Sodium 52-58 renin Rattus norvegicus 12-17 2570449-2 1989 Administration of propranolol, inhibited the renin release mediated by isoproterenol. Propranolol 18-29 renin Rattus norvegicus 45-50 2570449-2 1989 Administration of propranolol, inhibited the renin release mediated by isoproterenol. Isoproterenol 71-84 renin Rattus norvegicus 45-50 2570449-3 1989 Likewise, metoprolol and practolol, showed a similar potency to propranolol in inhibiting isoproterenol-induced renin secretion. Metoprolol 10-20 renin Rattus norvegicus 112-117 2570449-3 1989 Likewise, metoprolol and practolol, showed a similar potency to propranolol in inhibiting isoproterenol-induced renin secretion. Practolol 25-34 renin Rattus norvegicus 112-117 2570449-3 1989 Likewise, metoprolol and practolol, showed a similar potency to propranolol in inhibiting isoproterenol-induced renin secretion. Propranolol 64-75 renin Rattus norvegicus 112-117 2570449-3 1989 Likewise, metoprolol and practolol, showed a similar potency to propranolol in inhibiting isoproterenol-induced renin secretion. Isoproterenol 90-103 renin Rattus norvegicus 112-117 2570449-4 1989 These results suggest that the for isoproterenol-induced renin release in rats is a beta 1-type adrenoceptor. Isoproterenol 35-48 renin Rattus norvegicus 57-62 2655479-4 1989 The depressor response to neither agent changed over the next 40 h. The pressor response to angiotensin II was blunted significantly by 8 h and also did not change over the next 40 h. The findings indicate that the rapid tempo of sodium homeostasis in the rat is matched by an equally rapid tempo of activation of the renin-angiotensin system, although the factors responsible for aldosterone release are probably more complex. Sodium 230-236 renin Rattus norvegicus 318-323 2566577-0 1989 Evidence that specific dopamine-1 receptor activation is involved in dopamine-induced renin release. Dopamine 23-31 renin Rattus norvegicus 86-91 2655480-6 1989 Plasma renin activity was stimulated by low NaCl intake but was not different between the other two groups. Sodium Chloride 44-48 renin Rattus norvegicus 7-12 2566577-1 1989 Direct effects of dopamine on renin release were examined using static incubations and perifusions of rat renal cortical slices. Dopamine 18-26 renin Rattus norvegicus 30-35 2566577-2 1989 Dopamine (10(-5)M) significantly stimulated renin release compared with control. Dopamine 0-8 renin Rattus norvegicus 44-49 2566577-3 1989 To determine which receptors are involved in dopamine-elicited renin release, studies were performed with specific dopamine-1 and dopamine-2 receptor agonists and antagonists, as well as with alpha- and beta-adrenergic antagonists. Dopamine 45-53 renin Rattus norvegicus 63-68 2566577-4 1989 Fenoldopam, a dopamine-1 receptor agonist, dose dependently stimulated renin secretion both in static incubations and perifusions; whereas quinpirole (10(-7)-10(-5)M), a dopamine-2 receptor agonist, was ineffective. Fenoldopam 0-10 renin Rattus norvegicus 71-76 2566577-7 1989 SCH 23390 (10(-5)M), a specific dopamine-1 antagonist, blocked dopamine- and fenoldopam-induced renin. Dopamine 32-40 renin Rattus norvegicus 96-101 2566577-7 1989 SCH 23390 (10(-5)M), a specific dopamine-1 antagonist, blocked dopamine- and fenoldopam-induced renin. Fenoldopam 77-87 renin Rattus norvegicus 96-101 2566577-9 1989 These studies indicate that dopamine is a direct renin secretogogue, and its effects seem to be mediated by specific dopamine-1 receptor activation, as neither alpha- nor beta-adrenergic blockers nor dopamine-2 receptor antagonists altered dopamine actions. Dopamine 28-36 renin Rattus norvegicus 49-54 2566577-10 1989 The results suggest that dopamine produced locally in the kidney may stimulate renin secretion directly by dopamine-1 receptor activation. Dopamine 25-33 renin Rattus norvegicus 79-84 2539761-3 1989 Quinapril is efficacious in hypertensive models exhibiting both high (renal hypertensive rats, diuretic-treated dogs) and normal (spontaneously hypertensive rats) plasma renin activity. Quinapril 0-9 renin Rattus norvegicus 170-175 2650713-10 1989 The mechanism of the control of renin secretion from the adrenal gland was different from the kidney in that the secretion was stimulated by potassium chloride (10 mol/L) or angiotensin II (10(-9) to 10(-7) mol/L) but not by ACTH (10(-9) to 10(-7) mol/L), suggesting stimulation by intracellular calcium. Potassium Chloride 141-159 renin Rattus norvegicus 32-37 2650713-10 1989 The mechanism of the control of renin secretion from the adrenal gland was different from the kidney in that the secretion was stimulated by potassium chloride (10 mol/L) or angiotensin II (10(-9) to 10(-7) mol/L) but not by ACTH (10(-9) to 10(-7) mol/L), suggesting stimulation by intracellular calcium. Calcium 296-303 renin Rattus norvegicus 32-37 2666607-0 1989 Pharmacology of novel imidazole alcohol inhibitors of primate renin. imidazole alcohol 22-39 renin Rattus norvegicus 62-67 2666607-1 1989 SQ 30,774 and SQ 31,844 are representatives of a novel class of renin inhibitors, the imidazole alcohols. imidazole alcohols 86-104 renin Rattus norvegicus 64-69 2666607-2 1989 These compounds, which contain an imidazole ring as part of their active site binding group are potent in vitro inhibitors of primate renin, but not rat, hog of dog renin. imidazole 34-43 renin Rattus norvegicus 134-139 2651649-0 1989 Endogenous adenosine restrains renin release during sodium restriction. Adenosine 11-20 renin Rattus norvegicus 31-36 2651649-0 1989 Endogenous adenosine restrains renin release during sodium restriction. Sodium 52-58 renin Rattus norvegicus 31-36 2666607-7 1989 It is concluded that representatives of the imidazole alcohol class of renin inhibitors are potent inhibitors of renin in vitro and inhibit PRA and lower arterial pressure in vivo. imidazole alcohol 44-61 renin Rattus norvegicus 71-76 2651649-1 1989 The purpose of this study was to determine the role of endogenous adenosine in controlling renin release during both a normal and low sodium diet. Adenosine 66-75 renin Rattus norvegicus 91-96 2666607-7 1989 It is concluded that representatives of the imidazole alcohol class of renin inhibitors are potent inhibitors of renin in vitro and inhibit PRA and lower arterial pressure in vivo. imidazole alcohol 44-61 renin Rattus norvegicus 113-118 2651649-1 1989 The purpose of this study was to determine the role of endogenous adenosine in controlling renin release during both a normal and low sodium diet. Sodium 134-140 renin Rattus norvegicus 91-96 2651649-2 1989 To probe the involvement of endogenous adenosine in the control of renin release, we examined the effects of an adenosine receptor antagonist, 1,3-dipropyl-8-(p-sulfophenyl)xanthine (DPSPX), on renin release in rats fed either a normal or low sodium diet. Adenosine 39-48 renin Rattus norvegicus 67-72 2651649-2 1989 To probe the involvement of endogenous adenosine in the control of renin release, we examined the effects of an adenosine receptor antagonist, 1,3-dipropyl-8-(p-sulfophenyl)xanthine (DPSPX), on renin release in rats fed either a normal or low sodium diet. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 143-181 renin Rattus norvegicus 194-199 2651649-4 1989 DPSPX significantly increased arterial and renal venous levels of renin in both groups of animals; however, statistical analysis of the data (2-factor analysis of variance) indicated that DPSPX increased aortic and renal venous levels of renin more in rats fed a low sodium diet compared to rats fed a normal sodium diet. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 0-5 renin Rattus norvegicus 66-71 2649097-0 1989 Renin expression in the kidney and brain is reciprocally controlled by captopril. Captopril 71-80 renin Rattus norvegicus 0-5 2651649-4 1989 DPSPX significantly increased arterial and renal venous levels of renin in both groups of animals; however, statistical analysis of the data (2-factor analysis of variance) indicated that DPSPX increased aortic and renal venous levels of renin more in rats fed a low sodium diet compared to rats fed a normal sodium diet. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 188-193 renin Rattus norvegicus 66-71 2651649-4 1989 DPSPX significantly increased arterial and renal venous levels of renin in both groups of animals; however, statistical analysis of the data (2-factor analysis of variance) indicated that DPSPX increased aortic and renal venous levels of renin more in rats fed a low sodium diet compared to rats fed a normal sodium diet. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 188-193 renin Rattus norvegicus 238-243 2651649-4 1989 DPSPX significantly increased arterial and renal venous levels of renin in both groups of animals; however, statistical analysis of the data (2-factor analysis of variance) indicated that DPSPX increased aortic and renal venous levels of renin more in rats fed a low sodium diet compared to rats fed a normal sodium diet. Sodium 267-273 renin Rattus norvegicus 238-243 2651649-4 1989 DPSPX significantly increased arterial and renal venous levels of renin in both groups of animals; however, statistical analysis of the data (2-factor analysis of variance) indicated that DPSPX increased aortic and renal venous levels of renin more in rats fed a low sodium diet compared to rats fed a normal sodium diet. Sodium 309-315 renin Rattus norvegicus 238-243 2651649-6 1989 The effects of DPSPX on renin release could not be explained by changes in renal hemodynamics or excretory function. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 15-20 renin Rattus norvegicus 24-29 2652377-10 1989 Our data show that cadmium administration can influence UKE, plasma renin activity, plasma aldosterone concentration and electrolyte excretion without inducing any variation of blood pressure. Cadmium 19-26 renin Rattus norvegicus 68-73 2678161-0 1989 Alcohol intake is inversely related to plasma renin activity in the genetically selected alcohol-preferring and -nonpreferring lines of rats. Alcohols 0-7 renin Rattus norvegicus 46-51 2678161-0 1989 Alcohol intake is inversely related to plasma renin activity in the genetically selected alcohol-preferring and -nonpreferring lines of rats. Alcohols 89-96 renin Rattus norvegicus 46-51 2678161-3 1989 It has previously been shown that alcohol intake in randomly bred stock rats is sensitive to and inversely related to manipulations which alter activity in the renin-angiotensin (R-A) system. Alcohols 34-41 renin Rattus norvegicus 160-165 2678161-8 1989 It is suggested that the genetic selection that favored different levels of alcohol consumption in the P and NP rats may have brought about this effect through differences in the activity of the renin-angiotensin systems in the two lines. Alcohols 76-83 renin Rattus norvegicus 195-200 2495004-1 1989 BW-175 is a newly synthesized renin inhibitor which is a nonpeptidic, norleucine analog. Norleucine 70-80 renin Rattus norvegicus 30-35 2649097-3 1989 In response to sodium depletion and captopril treatment, the expression of mRNAs encoding rat renin were in a tissue-specific manner. Sodium 15-21 renin Rattus norvegicus 94-99 2649097-3 1989 In response to sodium depletion and captopril treatment, the expression of mRNAs encoding rat renin were in a tissue-specific manner. Captopril 36-45 renin Rattus norvegicus 94-99 2649097-4 1989 The level of kidney renin mRNA remarkably increased in sodium-depleted rats treated with captopril, whereas that of brain renin mRNA definitely decreased. Sodium 55-61 renin Rattus norvegicus 20-25 2649097-4 1989 The level of kidney renin mRNA remarkably increased in sodium-depleted rats treated with captopril, whereas that of brain renin mRNA definitely decreased. Captopril 89-98 renin Rattus norvegicus 20-25 2540388-5 1989 Plasma renin activity in all DOC-NaCl hypertensive groups was negligible. Desoxycorticosterone 29-32 renin Rattus norvegicus 7-12 2540388-5 1989 Plasma renin activity in all DOC-NaCl hypertensive groups was negligible. Sodium Chloride 33-37 renin Rattus norvegicus 7-12 2692882-1 1989 It is known that inbred Dahl salt-sensitive (S) rats carry a different renin allele than inbred Dahl salt-resistant (R) rats. dahl salt 24-33 renin Rattus norvegicus 71-76 2917684-5 1989 Over the same period plasma renin activity increased in adrenalectomized rats from 4.1 +/- 0.8 to 7.0 +/- 1.5 pmol angiotensin I (AI)/ml/h, and decreased in propylthiouracil-treated rats from 3.8 +/- 0.4 to 1.6 +/- 0.4 pmol AI/ml/h. Propylthiouracil 157-173 renin Rattus norvegicus 28-33 2563177-2 1989 A restriction fragment length polymorphism (RFLP) in the renin gene was found between Dahl salt-hypertension-sensitive (S) and Dahl salt-hypertension-resistant (R) rats. dahl salt 86-95 renin Rattus norvegicus 57-62 2563177-2 1989 A restriction fragment length polymorphism (RFLP) in the renin gene was found between Dahl salt-hypertension-sensitive (S) and Dahl salt-hypertension-resistant (R) rats. dahl salt 127-136 renin Rattus norvegicus 57-62 2545182-1 1989 Perindopril, a new specific and potent inhibitor of angiotensin-I-converting enzyme, was used to evaluate the possible participation of inhibition of the renin-angiotensin system in the development of aminoglycoside-induced renal failure. Perindopril 0-11 renin Rattus norvegicus 154-159 2545182-7 1989 These observations suggest that the integrity of the renin-angiotensin system may play an important role in limiting kidney injury during aminoglycoside-induced nephrotoxicity. Aminoglycosides 138-152 renin Rattus norvegicus 53-58 2691126-3 1989 Its intensity and duration are dose-dependent; they are increased in the presence of stimulation of the renin-angiotensin system (renovascular hypertension, sodium depletion). Sodium 157-163 renin Rattus norvegicus 104-109 2565535-0 1989 Structural differences in the renin gene of Dahl salt-sensitive and salt-resistant rats. dahl 44-48 renin Rattus norvegicus 30-35 2565535-0 1989 Structural differences in the renin gene of Dahl salt-sensitive and salt-resistant rats. Salts 49-53 renin Rattus norvegicus 30-35 2565535-0 1989 Structural differences in the renin gene of Dahl salt-sensitive and salt-resistant rats. Salts 68-72 renin Rattus norvegicus 30-35 2656313-2 1989 1) Inactive renin in the hypothalamus of captopril-administered SHR was significantly lower than that of control SHR and captopril-administered WKY. Captopril 41-50 renin Rattus norvegicus 12-17 2656313-2 1989 1) Inactive renin in the hypothalamus of captopril-administered SHR was significantly lower than that of control SHR and captopril-administered WKY. Captopril 121-130 renin Rattus norvegicus 12-17 2656313-3 1989 On the other hand, active renin in the hypothalamus, thalamus and striatum of captopril-administered SHR was significantly lower than that of control SHR and captopril-administered WKY. Captopril 78-87 renin Rattus norvegicus 26-31 2656313-3 1989 On the other hand, active renin in the hypothalamus, thalamus and striatum of captopril-administered SHR was significantly lower than that of control SHR and captopril-administered WKY. Captopril 158-167 renin Rattus norvegicus 26-31 2656313-4 1989 2) Inactive renin in the hypothalamus of trichlormethiazide administered SHR was significantly lower than that of control SHR and trichlormethiazide-administered WKY. Trichlormethiazide 41-59 renin Rattus norvegicus 12-17 2656313-4 1989 2) Inactive renin in the hypothalamus of trichlormethiazide administered SHR was significantly lower than that of control SHR and trichlormethiazide-administered WKY. Trichlormethiazide 130-148 renin Rattus norvegicus 12-17 2656313-5 1989 On the other hand, active renin in the hypothalamus, thalamus and midbrain of trichlormethiazide-administered SHR was significantly lower than that of control SHR and trichlormethiazide-administered WKY. Trichlormethiazide 78-96 renin Rattus norvegicus 26-31 2656313-5 1989 On the other hand, active renin in the hypothalamus, thalamus and midbrain of trichlormethiazide-administered SHR was significantly lower than that of control SHR and trichlormethiazide-administered WKY. Trichlormethiazide 167-185 renin Rattus norvegicus 26-31 2656313-6 1989 3) Inactive renin in the hypothalamus of atenolol-administered SHR was significantly lower than that of control SHR and atenolol-administered WKY. Atenolol 41-49 renin Rattus norvegicus 12-17 2656313-6 1989 3) Inactive renin in the hypothalamus of atenolol-administered SHR was significantly lower than that of control SHR and atenolol-administered WKY. Atenolol 120-128 renin Rattus norvegicus 12-17 2656313-7 1989 On the other hand, active renin in the hypothalamus, thalamus and midbrain of atenolol-administered SHR was significantly lower than that of control SHR and atenolol-administered WKY. Atenolol 78-86 renin Rattus norvegicus 26-31 2656313-7 1989 On the other hand, active renin in the hypothalamus, thalamus and midbrain of atenolol-administered SHR was significantly lower than that of control SHR and atenolol-administered WKY. Atenolol 157-165 renin Rattus norvegicus 26-31 2692882-2 1989 The levels of, and responses of, renal renin and renal renin mRNA to sodium deficient diet and to sodium deficient diet plus Captopril treatment were compared in S and R rats. Sodium 69-75 renin Rattus norvegicus 55-60 2692882-4 1989 Sodium deficient diet caused a modest increase, and sodium deficient diet plus Captopril caused a very large increase in both renal renin and renal renin mRNA in both strains. Sodium 52-58 renin Rattus norvegicus 132-137 2692882-4 1989 Sodium deficient diet caused a modest increase, and sodium deficient diet plus Captopril caused a very large increase in both renal renin and renal renin mRNA in both strains. Sodium 52-58 renin Rattus norvegicus 148-153 2692882-4 1989 Sodium deficient diet caused a modest increase, and sodium deficient diet plus Captopril caused a very large increase in both renal renin and renal renin mRNA in both strains. Captopril 79-88 renin Rattus norvegicus 132-137 2692882-4 1989 Sodium deficient diet caused a modest increase, and sodium deficient diet plus Captopril caused a very large increase in both renal renin and renal renin mRNA in both strains. Captopril 79-88 renin Rattus norvegicus 148-153 2542517-12 1989 From the data obtained, a kinetic model including the renin-angiotensin system and pharmacokinetics of captopril was constructed under the following assumptions; (1) the hypotensive effect of captopril is solely attributable to the reduction of angiotensin II level in the body, (2) the production rate of angiotensin II is proportional to the total ACE activity and (3) plasma ACE activity reflects the total ACE activity in the body. Captopril 192-201 renin Rattus norvegicus 54-59 2651516-6 1989 In contrast, severe sodium restriction blunted or prevented the development of hypertension in SHR and was associated with (1) marked increases in plasma renin activity (2) increased maintenance of blood pressure by the renin-angiotensin system (as assessed by captopril), and (3) a marked decrease in the blood pressure response to angiotensin II. Sodium 20-26 renin Rattus norvegicus 154-159 2651516-6 1989 In contrast, severe sodium restriction blunted or prevented the development of hypertension in SHR and was associated with (1) marked increases in plasma renin activity (2) increased maintenance of blood pressure by the renin-angiotensin system (as assessed by captopril), and (3) a marked decrease in the blood pressure response to angiotensin II. Sodium 20-26 renin Rattus norvegicus 220-225 2467083-2 1988 Dopamine (1.0 microM), the DA-1 dopamine receptor agonist fenoldopam (0.5 microM), and isoproterenol (1.0 microM) increased renin secretion markedly (130-200%). Dopamine 0-8 renin Rattus norvegicus 124-129 2464732-2 1989 Endothelin produced a concentration-dependent inhibition of renin release and this inhibitory effect was dependent on extracellular calcium. Calcium 132-139 renin Rattus norvegicus 60-65 2464732-4 1989 On the other hand, nifedipine completely antagonized the extracellular high potassium- or Bay K 8644-induced inhibition of renin release. Nifedipine 19-29 renin Rattus norvegicus 123-128 2464732-4 1989 On the other hand, nifedipine completely antagonized the extracellular high potassium- or Bay K 8644-induced inhibition of renin release. Potassium 76-85 renin Rattus norvegicus 123-128 2464732-4 1989 On the other hand, nifedipine completely antagonized the extracellular high potassium- or Bay K 8644-induced inhibition of renin release. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 90-100 renin Rattus norvegicus 123-128 2464732-7 1989 Thus, endothelin exerts an inhibitory action on renin release in vitro, in a calcium-dependent manner. Calcium 77-84 renin Rattus norvegicus 48-53 2472542-1 1989 Our previous study on kidney cortical slices showed that Bay K 8644, a dihydropyridine calcium channel agonist, produced a dose-dependent inhibitory action on the release of renin. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 57-67 renin Rattus norvegicus 174-179 2522661-6 1989 Ramipril increased plasma renin activity levels both in indomethacin treated and untreated rats on days 1 (p less than 0.01) and 7 (p less than 0.05). Ramipril 0-8 renin Rattus norvegicus 26-31 2522661-6 1989 Ramipril increased plasma renin activity levels both in indomethacin treated and untreated rats on days 1 (p less than 0.01) and 7 (p less than 0.05). Indomethacin 56-68 renin Rattus norvegicus 26-31 3214543-3 1988 These treatments were also shown to produce the expected changes in the renin-angiotensin-aldosterone system, which thus appears to be involved in the induction of an appetite for NaCl solution in this strain of rat. nacl solution 180-193 renin Rattus norvegicus 72-77 3074918-1 1988 The present study was designed to investigate the involvement of the renal nerve in glucocorticoid hypertension and to assess the role of the renin-angiotensin system in dexamethasone-induced hypertension. Dexamethasone 170-183 renin Rattus norvegicus 142-147 3074918-2 1988 The elevated blood pressure in dexamethasone treated rats showing a significant increase in plasma renin concentration (PRC) and activity (PRA) was attenuated dose-dependently by the angiotensin I converting enzyme (ACE) inhibition. Dexamethasone 31-44 renin Rattus norvegicus 99-104 3074918-5 1988 Thus, our results indicate that the stimulation of the renin-angiotensin system through the activation of the renal nerve may be partially responsible for the dexamethasone-induced high blood pressure and, therefore, bilateral renal denervation reduces, partially but significantly, the elevated blood pressure, suggesting that the attenuation of oversecretion of renin contributes to the lowering of the blood pressure. Dexamethasone 159-172 renin Rattus norvegicus 55-60 3074918-5 1988 Thus, our results indicate that the stimulation of the renin-angiotensin system through the activation of the renal nerve may be partially responsible for the dexamethasone-induced high blood pressure and, therefore, bilateral renal denervation reduces, partially but significantly, the elevated blood pressure, suggesting that the attenuation of oversecretion of renin contributes to the lowering of the blood pressure. Dexamethasone 159-172 renin Rattus norvegicus 364-369 3074734-0 1988 Sodium appetite: species and strain differences and role of renin-angiotensin-aldosterone system. Sodium 0-6 renin Rattus norvegicus 60-65 2467083-2 1988 Dopamine (1.0 microM), the DA-1 dopamine receptor agonist fenoldopam (0.5 microM), and isoproterenol (1.0 microM) increased renin secretion markedly (130-200%). Fenoldopam 58-68 renin Rattus norvegicus 124-129 2467083-2 1988 Dopamine (1.0 microM), the DA-1 dopamine receptor agonist fenoldopam (0.5 microM), and isoproterenol (1.0 microM) increased renin secretion markedly (130-200%). Isoproterenol 87-100 renin Rattus norvegicus 124-129 2467083-4 1988 In contrast, SCH 23390 (0.01 microM), a DA-1 dopamine receptor antagonist, inhibited markedly only the renin release evoked by the latter two agonists, whereas S-sulpiride (10 microM), a DA-2 dopamine receptor antagonist, and phentolamine (10 microM), a nonselective alpha-adrenoceptor antagonist, did not modify the effects of either dopamine or fenoldopam. SCH 23390 13-22 renin Rattus norvegicus 103-108 2467083-4 1988 In contrast, SCH 23390 (0.01 microM), a DA-1 dopamine receptor antagonist, inhibited markedly only the renin release evoked by the latter two agonists, whereas S-sulpiride (10 microM), a DA-2 dopamine receptor antagonist, and phentolamine (10 microM), a nonselective alpha-adrenoceptor antagonist, did not modify the effects of either dopamine or fenoldopam. Sulfur 13-14 renin Rattus norvegicus 103-108 2467083-5 1988 In rats, pithed to eliminate reflexogenic mechanisms regulating renin release, at the end of a 15 min i.v. pithed 9-15 renin Rattus norvegicus 64-69 2467083-6 1988 infusion of fenoldopam (20 micrograms/kg per min) there was a significant increase in plasma renin activity. Fenoldopam 12-22 renin Rattus norvegicus 93-98 2467083-11 1988 In conclusion, these results indicate that DA-1 dopamine receptors are present in rat kidney JG cells and that pharmacological stimulation of these receptors with dopamine or fenoldopam leads to renin secretion. Dopamine 48-56 renin Rattus norvegicus 195-200 3071584-0 1988 Interaction between the vascular renin-angiotensin system and prostaglandins. Prostaglandins 62-76 renin Rattus norvegicus 33-38 2467083-11 1988 In conclusion, these results indicate that DA-1 dopamine receptors are present in rat kidney JG cells and that pharmacological stimulation of these receptors with dopamine or fenoldopam leads to renin secretion. Fenoldopam 175-185 renin Rattus norvegicus 195-200 2977165-3 1988 In the high-sodium state, renal renin mRNA decreased, but it increased in the low-sodium state. Sodium 12-18 renin Rattus norvegicus 32-37 2977165-4 1988 A further increase in renin mRNA was seen in the low-sodium state after captopril administration. Sodium 53-59 renin Rattus norvegicus 22-27 2853724-7 1988 Plasma renin activity increased on lisinopril treatment in all groups except DS rats on the high-salt diet. Lisinopril 35-45 renin Rattus norvegicus 7-12 3071584-1 1988 The effects of nephrectomy, prostacyclin (PGI2), prostaglandin E2 (PGE2) and indomethacin on the vascular renin-angiotensin system were examined using isolated perfused mesenteric arteries. Indomethacin 77-89 renin Rattus norvegicus 106-111 2853724-7 1988 Plasma renin activity increased on lisinopril treatment in all groups except DS rats on the high-salt diet. Salts 97-101 renin Rattus norvegicus 7-12 2977165-4 1988 A further increase in renin mRNA was seen in the low-sodium state after captopril administration. Captopril 72-81 renin Rattus norvegicus 22-27 3071584-6 1988 Infusion of PGI2 (10(-6) mol/l) and PGE2 (10(-6) mol/l) for 1 h caused significant decreases in Ang II release (P less than 0.01 and P less than 0.05, respectively) and also decreased vascular renin activity. Epoprostenol 12-16 renin Rattus norvegicus 193-198 3071584-6 1988 Infusion of PGI2 (10(-6) mol/l) and PGE2 (10(-6) mol/l) for 1 h caused significant decreases in Ang II release (P less than 0.01 and P less than 0.05, respectively) and also decreased vascular renin activity. Dinoprostone 36-40 renin Rattus norvegicus 193-198 3071584-7 1988 In contrast, infusion of indomethacin (10(-6) mol/l) for 1 h resulted in an increase (P less than 0.01) in vascular renin activity. Indomethacin 25-37 renin Rattus norvegicus 116-121 3071584-9 1988 In contrast with their effects on renal renin, prostaglandins suppress the vascular renin-angiotensin system. Prostaglandins 47-61 renin Rattus norvegicus 84-89 3072488-5 1988 The increases in plasma renin activity were blocked by propranolol. Propranolol 55-66 renin Rattus norvegicus 24-29 3139395-7 1988 In the hypophysectomized diethylstilbestrol-treated rat ovary, over 90% of active renin remained in the residual ovary after the granulosa cells had been expressed, suggesting a theca-interstitial localization for renin. Diethylstilbestrol 25-43 renin Rattus norvegicus 82-87 2856469-7 1988 Sodium loading in the presence of reduced renal mass (unilateral nephrectomy) or mineralocorticoid administration produced renin suppression and resulted in down-regulation of vascular ANP receptors. Sodium 0-6 renin Rattus norvegicus 123-128 3254766-8 1988 Plasma renin activity was significantly reduced in those animals receiving potassium after 5 weeks. Potassium 75-84 renin Rattus norvegicus 7-12 3254766-10 1988 It is proposed that a combination of increased systemic and/or renal prostacyclin and kallikrein synthesis may, in combination with reduced renin activity, contribute to the attenuation of blood pressure in potassium-supplemented spontaneously hypertensive rats. Potassium 207-216 renin Rattus norvegicus 140-145 3069523-7 1988 63-75) we showed that thirst elicited by activation of the brain"s renin-angiotensin system in the suckling becomes specific to water after 16 days of age. Water 128-133 renin Rattus norvegicus 67-72 3139395-7 1988 In the hypophysectomized diethylstilbestrol-treated rat ovary, over 90% of active renin remained in the residual ovary after the granulosa cells had been expressed, suggesting a theca-interstitial localization for renin. Diethylstilbestrol 25-43 renin Rattus norvegicus 214-219 3051994-8 1988 Thus, in vivo renin release is inhibited by hypercalcemia and stimulated by blocking calcium transport; conversely, aldosterone production is stimulated by a high calcium intake and inhibited by blocking calcium transport. Calcium 85-92 renin Rattus norvegicus 14-19 3051994-0 1988 Effects of calcium on renin and aldosterone. Calcium 11-18 renin Rattus norvegicus 22-27 3051994-9 1988 These effects of calcium on renin and aldosterone may have implications for understanding the putative relation between calcium and hypertension. Calcium 17-24 renin Rattus norvegicus 28-33 3051994-1 1988 A series of experiments was undertaken to assess the effects of calcium administration, in vivo, on renin and aldosterone secretion. Calcium 64-71 renin Rattus norvegicus 100-105 3051994-3 1988 In the sodium chloride-deprived rat, dietary calcium chloride loading decreased plasma renin activity, whereas calcium gluconate did not. Sodium Chloride 7-22 renin Rattus norvegicus 87-92 3051994-9 1988 These effects of calcium on renin and aldosterone may have implications for understanding the putative relation between calcium and hypertension. Calcium 120-127 renin Rattus norvegicus 28-33 2851439-2 1988 After 2 days of daily sc injection of ACTH (Cortrosyn-Zinc, 50 micrograms/day), parallel increases in adrenal renin and aldosterone, and plasma aldosterone (PA) were induced. cortrosyn-zinc 44-58 renin Rattus norvegicus 110-115 3051994-3 1988 In the sodium chloride-deprived rat, dietary calcium chloride loading decreased plasma renin activity, whereas calcium gluconate did not. Calcium Chloride 45-61 renin Rattus norvegicus 87-92 3067601-5 1988 Evidence was presented for a relationship between activity in the renin-angiotensin system and the self-administration of ethanol. Ethanol 122-129 renin Rattus norvegicus 66-71 3052110-0 1988 Stimulatory effects of neuronally released norepinephrine on renin release in vitro. Norepinephrine 43-57 renin Rattus norvegicus 61-66 3052110-1 1988 Extracellular high potassium inhibits renin release in vitro by increasing calcium concentrations in the juxtaglomerular cells. Potassium 19-28 renin Rattus norvegicus 38-43 3052110-1 1988 Extracellular high potassium inhibits renin release in vitro by increasing calcium concentrations in the juxtaglomerular cells. Calcium 75-82 renin Rattus norvegicus 38-43 3052110-2 1988 We found that the decreased response of renin release from rat kidney cortical slices in high potassium solution (20-80 mM) changed to a strikingly increased one in the presence of nifedipine at doses over 10(-6) M. We then examined the stimulatory effect of extracellular high potassium in the presence of nifedipine on renin release. Potassium 94-103 renin Rattus norvegicus 40-45 3052110-2 1988 We found that the decreased response of renin release from rat kidney cortical slices in high potassium solution (20-80 mM) changed to a strikingly increased one in the presence of nifedipine at doses over 10(-6) M. We then examined the stimulatory effect of extracellular high potassium in the presence of nifedipine on renin release. Nifedipine 181-191 renin Rattus norvegicus 40-45 3052110-2 1988 We found that the decreased response of renin release from rat kidney cortical slices in high potassium solution (20-80 mM) changed to a strikingly increased one in the presence of nifedipine at doses over 10(-6) M. We then examined the stimulatory effect of extracellular high potassium in the presence of nifedipine on renin release. Nifedipine 181-191 renin Rattus norvegicus 321-326 3052110-4 1988 High potassium plus nifedipine-induced increase in renin release was markedly attenuated by renal denervation. Potassium 5-14 renin Rattus norvegicus 51-56 3052110-4 1988 High potassium plus nifedipine-induced increase in renin release was markedly attenuated by renal denervation. Nifedipine 20-30 renin Rattus norvegicus 51-56 3052110-9 1988 These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors. Potassium 47-56 renin Rattus norvegicus 93-98 3052110-9 1988 These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors. Potassium 47-56 renin Rattus norvegicus 251-256 3052110-9 1988 These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors. Nifedipine 62-72 renin Rattus norvegicus 93-98 3052110-9 1988 These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors. Nifedipine 62-72 renin Rattus norvegicus 251-256 3052110-9 1988 These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors. Norepinephrine 138-152 renin Rattus norvegicus 93-98 3052110-9 1988 These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors. Norepinephrine 225-239 renin Rattus norvegicus 93-98 3052110-9 1988 These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors. Norepinephrine 225-239 renin Rattus norvegicus 251-256 3049341-3 1988 Deoxycorticosterone acetate (DOCA) and high salt (1%) treatment of experimental animals resulted in a greater than 95% decrease in the content of renin mRNA in the kidney, as compared with values in control rats receiving 0.4% NaCl in their diet. Desoxycorticosterone Acetate 0-27 renin Rattus norvegicus 146-151 3049341-3 1988 Deoxycorticosterone acetate (DOCA) and high salt (1%) treatment of experimental animals resulted in a greater than 95% decrease in the content of renin mRNA in the kidney, as compared with values in control rats receiving 0.4% NaCl in their diet. Desoxycorticosterone Acetate 29-33 renin Rattus norvegicus 146-151 2851439-4 1988 Prolonged treatment with ACTH for 8 days increased the adrenal renin, causing a marked reduction in the adrenal aldosterone concentration. Aldosterone 112-123 renin Rattus norvegicus 63-68 3049341-3 1988 Deoxycorticosterone acetate (DOCA) and high salt (1%) treatment of experimental animals resulted in a greater than 95% decrease in the content of renin mRNA in the kidney, as compared with values in control rats receiving 0.4% NaCl in their diet. Salts 44-48 renin Rattus norvegicus 146-151 3049341-3 1988 Deoxycorticosterone acetate (DOCA) and high salt (1%) treatment of experimental animals resulted in a greater than 95% decrease in the content of renin mRNA in the kidney, as compared with values in control rats receiving 0.4% NaCl in their diet. Sodium Chloride 227-231 renin Rattus norvegicus 146-151 3046823-0 1988 Longitudinal study of renal prostaglandin excretion in cirrhotic rats: relationship with the renin-aldosterone system. Prostaglandins 28-41 renin Rattus norvegicus 93-98 3049341-4 1988 In contrast, high salt (1%) treatment alone caused only a twofold decrease in kidney renin mRNA content, as compared with values in controls. Salts 18-22 renin Rattus norvegicus 85-90 3049341-5 1988 DOCA and low salt (0.04%) or low salt (0.04%) treatment alone caused a 1.5-fold increase in the kidney renin mRNA content, as compared with values in control rats. Desoxycorticosterone Acetate 0-4 renin Rattus norvegicus 103-108 3049341-5 1988 DOCA and low salt (0.04%) or low salt (0.04%) treatment alone caused a 1.5-fold increase in the kidney renin mRNA content, as compared with values in control rats. Salts 13-17 renin Rattus norvegicus 103-108 3049341-5 1988 DOCA and low salt (0.04%) or low salt (0.04%) treatment alone caused a 1.5-fold increase in the kidney renin mRNA content, as compared with values in control rats. Salts 33-37 renin Rattus norvegicus 103-108 3049341-6 1988 These results indicate that DOCA and salt have a synergistic effect in depressing renin mRNA levels in kidney. Desoxycorticosterone Acetate 28-32 renin Rattus norvegicus 82-87 3049341-6 1988 These results indicate that DOCA and salt have a synergistic effect in depressing renin mRNA levels in kidney. Salts 37-41 renin Rattus norvegicus 82-87 3171969-8 1988 Blockade of the renin-angiotensin system by captopril, saralasin or bilateral nephrectomy inhibited significantly but did not abolish completely the hypotensive effect of S-8307 in furosemide-treated rats. Captopril 44-53 renin Rattus norvegicus 16-21 3062061-7 1988 Inhibition of the renin-angiotensin system (with captopril) had a slightly greater hypotensive effect in Brattleboro than in Long Evans rats. Captopril 49-58 renin Rattus norvegicus 18-23 3062573-0 1988 Renin-dependent water intake in hypovolemia. Water 16-21 renin Rattus norvegicus 0-5 3062573-1 1988 The role of the renin-angiotensin system as a mediator of water intake, induced by hypovolemia after polyethylene glycol (PEG) injection, was investigated. Water 58-63 renin Rattus norvegicus 16-21 3062573-1 1988 The role of the renin-angiotensin system as a mediator of water intake, induced by hypovolemia after polyethylene glycol (PEG) injection, was investigated. Polyethylene Glycols 122-125 renin Rattus norvegicus 16-21 3062573-7 1988 We conclude that water intake due to isotonic depletion of the extracellular fluid compartment may depend on the activity of the renin-angiotensin system. Water 17-22 renin Rattus norvegicus 129-134 3052444-2 1988 Endothelin inhibited basal renin release in a dose-dependent manner with an IC50 of 1.0 x 10(-9) M. Endothelin also inhibited renin release stimulated by isoproterenol (10(-5) M). Isoproterenol 154-167 renin Rattus norvegicus 27-32 3052444-2 1988 Endothelin inhibited basal renin release in a dose-dependent manner with an IC50 of 1.0 x 10(-9) M. Endothelin also inhibited renin release stimulated by isoproterenol (10(-5) M). Isoproterenol 154-167 renin Rattus norvegicus 126-131 3052444-3 1988 Nifedipine (10(-5) M), a calcium channel blocker, induced an increase in renin release. Nifedipine 0-10 renin Rattus norvegicus 73-78 3052444-5 1988 These results suggest that endothelin inhibits renin release via a calcium entry mechanism and increases intracellular calcium. Calcium 67-74 renin Rattus norvegicus 47-52 3048114-0 1988 Triton WR-1339 injected into rats enters renal renin granules. tyloxapol 0-14 renin Rattus norvegicus 47-52 3046823-12 1988 In CCl4 rats included in protocol B, there was a close chronological relationship between the activation of the renin-aldosterone system, as estimated by urinary aldosterone excretion, the onset of sodium retention and the increase in urinary excretion of 6-keto-PGF1 alpha and TXB2. Sodium 198-204 renin Rattus norvegicus 112-117 3046823-12 1988 In CCl4 rats included in protocol B, there was a close chronological relationship between the activation of the renin-aldosterone system, as estimated by urinary aldosterone excretion, the onset of sodium retention and the increase in urinary excretion of 6-keto-PGF1 alpha and TXB2. 6-keto-pgf1 256-267 renin Rattus norvegicus 112-117 3046823-12 1988 In CCl4 rats included in protocol B, there was a close chronological relationship between the activation of the renin-aldosterone system, as estimated by urinary aldosterone excretion, the onset of sodium retention and the increase in urinary excretion of 6-keto-PGF1 alpha and TXB2. Thromboxane B2 278-282 renin Rattus norvegicus 112-117 3045320-11 1988 One of the compounds, acetyl-His-Pro-Phe-Val-Statine-Leu-Phe-NH2 (IC50 against rat plasma renin of 30 nM at pH 7.4), proved to be a potent hypotensive agent and a potentially useful probe for the study of the renin-angiotensin system in rats. acetyl-his 22-32 renin Rattus norvegicus 90-95 2843564-10 1988 The mechanism of the control of renin secretion from the adrenal gland was different from the kidney in that the secretion was stimulated by potassium chloride (10 mM) or angiotensin II (10(-9)-10(-7) M) but not by ACTH (10(-9)-10(-7) M), suggesting stimulation by intracellular calcium. Potassium Chloride 141-159 renin Rattus norvegicus 32-37 2843564-10 1988 The mechanism of the control of renin secretion from the adrenal gland was different from the kidney in that the secretion was stimulated by potassium chloride (10 mM) or angiotensin II (10(-9)-10(-7) M) but not by ACTH (10(-9)-10(-7) M), suggesting stimulation by intracellular calcium. Calcium 279-286 renin Rattus norvegicus 32-37 3045320-11 1988 One of the compounds, acetyl-His-Pro-Phe-Val-Statine-Leu-Phe-NH2 (IC50 against rat plasma renin of 30 nM at pH 7.4), proved to be a potent hypotensive agent and a potentially useful probe for the study of the renin-angiotensin system in rats. acetyl-his 22-32 renin Rattus norvegicus 209-214 3045320-11 1988 One of the compounds, acetyl-His-Pro-Phe-Val-Statine-Leu-Phe-NH2 (IC50 against rat plasma renin of 30 nM at pH 7.4), proved to be a potent hypotensive agent and a potentially useful probe for the study of the renin-angiotensin system in rats. pro-phe-val-statine-leu-phe-nh2 33-64 renin Rattus norvegicus 90-95 3047366-0 1988 Cardiovascular actions of the primate-selective renin inhibitor, A-62198. A 62198 65-72 renin Rattus norvegicus 48-53 3045320-11 1988 One of the compounds, acetyl-His-Pro-Phe-Val-Statine-Leu-Phe-NH2 (IC50 against rat plasma renin of 30 nM at pH 7.4), proved to be a potent hypotensive agent and a potentially useful probe for the study of the renin-angiotensin system in rats. pro-phe-val-statine-leu-phe-nh2 33-64 renin Rattus norvegicus 209-214 3047366-1 1988 A-62198 [dimethylacetyl-Phe-His-NHCH(cyclohexylmethyl)CH-(OH)C H(OH)CH2N3] is a potent, selective inhibitor of primate renin. dimethylacetyl-phe-his 9-31 renin Rattus norvegicus 119-124 2970225-0 1988 Sodium balance effects on renin, angiotensinogen, and atrial natriuretic polypeptide mRNA levels. Sodium 0-6 renin Rattus norvegicus 26-31 3047366-13 1988 We conclude that the renin inhibitor, A-62198, is an effective, primate selective hypotensive agent. A 62198 38-45 renin Rattus norvegicus 21-26 3066645-13 1988 In addition, Mg ion was found to play an important role in the biosynthesis of renin and steroid hormones but to have no such significant role in the urinary excretions of kinin, PGE2, and 6-keto-PGF1 alpha. Magnesium 13-15 renin Rattus norvegicus 79-84 3044145-8 1988 Intracranial captopril inhibited renin- and ANG I-induced but not ANG II-induced drinking. Captopril 13-22 renin Rattus norvegicus 33-38 2469063-1 1988 Substance P (SP) acutely enhanced the plasma concentration of aldosterone in rats whose hypothalamo-hypophyseal-adrenal axis and renin-angiotensin system were pharmacologically interrupted. Aldosterone 62-73 renin Rattus norvegicus 129-134 2970225-4 1988 In the high-sodium state, plasma renin concentration (PRC), renal renin concentration (RRC), and renal renin mRNA decreased by 88, 90, and 75%, respectively. Sodium 12-18 renin Rattus norvegicus 33-38 2970225-4 1988 In the high-sodium state, plasma renin concentration (PRC), renal renin concentration (RRC), and renal renin mRNA decreased by 88, 90, and 75%, respectively. Sodium 12-18 renin Rattus norvegicus 66-71 2970225-4 1988 In the high-sodium state, plasma renin concentration (PRC), renal renin concentration (RRC), and renal renin mRNA decreased by 88, 90, and 75%, respectively. Sodium 12-18 renin Rattus norvegicus 66-71 3041828-7 1988 Unlike rat models, which suggest cyclosporine-induced stimulation of the renin-angiotensin system, or previous forms of post-transplant hypertension in humans, plasma renin levels were not elevated and blood pressure did not respond to a test dose of captopril. Cyclosporine 33-45 renin Rattus norvegicus 73-78 2970225-5 1988 In the low-sodium state, PRC, RRC, and renin mRNA increased 17-fold, 2.5-fold, and 4.5-fold, respectively. Sodium 11-17 renin Rattus norvegicus 39-44 2970225-6 1988 With captopril treatment during sodium depletion, PRC and renin mRNA increased 144-fold and 17.1-fold, respectively, and RRC increased 4.2-fold. Captopril 5-14 renin Rattus norvegicus 58-63 3407785-8 1988 This regulation would increase TALH NaCl reabsorption (decrease luminal NaCl concentration) and therefore influence 1) the urinary concentrating mechanism, and 2) renin secretion via the macula densa mechanism. Sodium Chloride 36-40 renin Rattus norvegicus 163-168 2970225-10 1988 These results demonstrate that sodium intake affects the expression of the renin and angiotensinogen genes and slightly alters the expression of ANP gene. Sodium 31-37 renin Rattus norvegicus 75-80 3407785-8 1988 This regulation would increase TALH NaCl reabsorption (decrease luminal NaCl concentration) and therefore influence 1) the urinary concentrating mechanism, and 2) renin secretion via the macula densa mechanism. Sodium Chloride 72-76 renin Rattus norvegicus 163-168 2899463-9 1988 The results suggest that high circulating atrial natriuretic peptide levels may prevent or limit salt and water retention, either directly or indirectly, by inhibiting the renin-angiotensin-aldosterone system. Salts 97-101 renin Rattus norvegicus 172-177 3052427-2 1988 In two of these sites, the brain and the liver, renin mRNA levels are unaffected by changes in dietary salt which markedly affect renal renin mRNA levels. Salts 103-107 renin Rattus norvegicus 136-141 2856063-0 1988 Calmodulin-independent stimulation of renin release by exposure of rat kidney cortical slices to calcium. Calcium 97-104 renin Rattus norvegicus 38-43 2899463-9 1988 The results suggest that high circulating atrial natriuretic peptide levels may prevent or limit salt and water retention, either directly or indirectly, by inhibiting the renin-angiotensin-aldosterone system. Water 106-111 renin Rattus norvegicus 172-177 2856063-2 1988 Effects of calcium-interacting agents on the calcium-induced stimulation of renin release from kidney cortical slices pretreated with calcium-free medium were examined. Calcium 45-52 renin Rattus norvegicus 76-81 2856063-2 1988 Effects of calcium-interacting agents on the calcium-induced stimulation of renin release from kidney cortical slices pretreated with calcium-free medium were examined. Calcium 45-52 renin Rattus norvegicus 76-81 3069064-0 1988 The renin-angiotensin system and intraperitoneal toxicity: possible basis to urethane anaesthesia-induced reductions in renal clearance in the rat. Urethane 77-85 renin Rattus norvegicus 4-9 2856063-4 1988 The exposure of calcium to the slices pretreated with calcium-free medium enhanced the release of renin, followed by a decreased response in the release. Calcium 16-23 renin Rattus norvegicus 98-103 2856063-4 1988 The exposure of calcium to the slices pretreated with calcium-free medium enhanced the release of renin, followed by a decreased response in the release. Calcium 54-61 renin Rattus norvegicus 98-103 2856063-7 1988 High potassium depolarization significantly potentiated the decreased response of renin release, with no influence on the stimulation of the release by exposure to calcium. Potassium 5-14 renin Rattus norvegicus 82-87 2856063-9 1988 The decrease in renin release was attenuated by calcium-interacting agents, such as nifedipine, TMB-8 and W-7, but these agents were without effect on the stimulation of the release by exposure to calcium. Calcium 48-55 renin Rattus norvegicus 16-21 2856063-9 1988 The decrease in renin release was attenuated by calcium-interacting agents, such as nifedipine, TMB-8 and W-7, but these agents were without effect on the stimulation of the release by exposure to calcium. Nifedipine 84-94 renin Rattus norvegicus 16-21 2856063-9 1988 The decrease in renin release was attenuated by calcium-interacting agents, such as nifedipine, TMB-8 and W-7, but these agents were without effect on the stimulation of the release by exposure to calcium. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 96-101 renin Rattus norvegicus 16-21 2856063-9 1988 The decrease in renin release was attenuated by calcium-interacting agents, such as nifedipine, TMB-8 and W-7, but these agents were without effect on the stimulation of the release by exposure to calcium. W 7 106-109 renin Rattus norvegicus 16-21 3044993-0 1988 Adenosine in renin-dependent renovascular hypertension. Adenosine 0-9 renin Rattus norvegicus 13-18 3044993-1 1988 Our previous studies support the hypothesis that activation of the renin-angiotensin system by renal ischemia elevates adenosine levels and that adenosine acts in a negative feedback loop to limit renin release and to mitigate some of the hypertension-producing effects of angiotensin II. Adenosine 119-128 renin Rattus norvegicus 67-72 3044993-1 1988 Our previous studies support the hypothesis that activation of the renin-angiotensin system by renal ischemia elevates adenosine levels and that adenosine acts in a negative feedback loop to limit renin release and to mitigate some of the hypertension-producing effects of angiotensin II. Adenosine 145-154 renin Rattus norvegicus 197-202 3044993-2 1988 To further test this hypothesis, we compared the time course of caffeine-induced increases in plasma renin activity with the time course of changes in plasma levels of adenosine in two models of renin-dependent renovascular hypertension. Caffeine 64-72 renin Rattus norvegicus 101-106 3044993-6 1988 In 2K1C rats treated chronically with caffeine, plasma renin activity was markedly elevated during the first week after operation as compared to non-caffeine-treated 2K1C rats. Caffeine 38-46 renin Rattus norvegicus 55-60 3044993-6 1988 In 2K1C rats treated chronically with caffeine, plasma renin activity was markedly elevated during the first week after operation as compared to non-caffeine-treated 2K1C rats. Caffeine 149-157 renin Rattus norvegicus 55-60 3044993-7 1988 However, during the second and third weeks after clipping, caffeine had lesser effects on plasma renin activity. Caffeine 59-67 renin Rattus norvegicus 97-102 3044993-9 1988 Caffeine accelerated hypertension in 2K1C rats and rats with aortic ligation (renin-dependent renovascular hypertension), but it had no effect on plasma renin activity or blood pressure in one-kidney, one clip rats (renin-independent renovascular hypertension). Caffeine 0-8 renin Rattus norvegicus 78-83 3044993-10 1988 These results lend further support to the hypothesis that adenosine functions to mitigate the renin-angiotensin system in renin-dependent renovascular hypertension. Adenosine 58-67 renin Rattus norvegicus 94-99 3044993-10 1988 These results lend further support to the hypothesis that adenosine functions to mitigate the renin-angiotensin system in renin-dependent renovascular hypertension. Adenosine 58-67 renin Rattus norvegicus 122-127 3293466-2 1988 Renin was labeled with [35S]methionine by incubating the cortical slices for 2 h. The labeled immunoprecipitable renin was found in microsomal fraction (F1) but not in the renin granule fraction (F2). Sulfur-35 24-27 renin Rattus norvegicus 0-5 3293466-2 1988 Renin was labeled with [35S]methionine by incubating the cortical slices for 2 h. The labeled immunoprecipitable renin was found in microsomal fraction (F1) but not in the renin granule fraction (F2). Sulfur-35 24-27 renin Rattus norvegicus 113-118 3293466-2 1988 Renin was labeled with [35S]methionine by incubating the cortical slices for 2 h. The labeled immunoprecipitable renin was found in microsomal fraction (F1) but not in the renin granule fraction (F2). Methionine 28-38 renin Rattus norvegicus 0-5 2846685-8 1988 Plasma renin activity (PRA) increased sharply in both groups of rats treated with the lower doses of lisinopril, only to decrease at the 5 mg/kg level. Lisinopril 101-111 renin Rattus norvegicus 7-12 3293466-2 1988 Renin was labeled with [35S]methionine by incubating the cortical slices for 2 h. The labeled immunoprecipitable renin was found in microsomal fraction (F1) but not in the renin granule fraction (F2). Methionine 28-38 renin Rattus norvegicus 113-118 2837909-6 1988 Whereas in the control kidney renin was localized in a juxtaglomerular position, in the kidneys from enalapril-treated rats, renin immunoreactivity of the afferent arteriole extended well beyond the juxtaglomerular loci in the direction of the interlobular artery. Enalapril 101-110 renin Rattus norvegicus 30-35 2840395-9 1988 These results suggest that the renin-angiotensin in the hind legs is modulated by prostaglandins and that a difference exists in the beta-adrenergic receptor-mediated release of Ang II among diverse vascular beds. Prostaglandins 82-96 renin Rattus norvegicus 31-36 2837909-3 1988 Renin mRNA levels in the enalapril-treated group were 4.6-fold higher than in the control group (P less than 0.05). Enalapril 25-34 renin Rattus norvegicus 0-5 2837909-6 1988 Whereas in the control kidney renin was localized in a juxtaglomerular position, in the kidneys from enalapril-treated rats, renin immunoreactivity of the afferent arteriole extended well beyond the juxtaglomerular loci in the direction of the interlobular artery. Enalapril 101-110 renin Rattus norvegicus 125-130 2837909-7 1988 The percent of afferent arteriolar length immunostained for renin was higher in the enalapril-treated (53 +/- 17%) than in the control (33 +/- 15) group. Enalapril 84-93 renin Rattus norvegicus 60-65 3134306-5 1988 Oral administration of ES 6864 at 30 mg/kg to conscious, sodium-depleted marmosets produced a significant blood pressure reduction and almost complete inhibition of plasma renin activity, which persisted for 5 hours. ES 6864 23-30 renin Rattus norvegicus 172-177 3060354-2 1988 In rats, when lead exposure is begun several weeks after birth in doses that cause blood lead concentrations (PbB) of 30 to 40 micrograms/dL, the result is an increase in basal plasma renin activity (PRA) and renal renin concentration, with no change in the metabolic clearance of renin; this is presumptive evidence for increased renin secretion. Polybrominated Biphenyls 110-113 renin Rattus norvegicus 184-189 3060354-2 1988 In rats, when lead exposure is begun several weeks after birth in doses that cause blood lead concentrations (PbB) of 30 to 40 micrograms/dL, the result is an increase in basal plasma renin activity (PRA) and renal renin concentration, with no change in the metabolic clearance of renin; this is presumptive evidence for increased renin secretion. Polybrominated Biphenyls 110-113 renin Rattus norvegicus 215-220 3060354-2 1988 In rats, when lead exposure is begun several weeks after birth in doses that cause blood lead concentrations (PbB) of 30 to 40 micrograms/dL, the result is an increase in basal plasma renin activity (PRA) and renal renin concentration, with no change in the metabolic clearance of renin; this is presumptive evidence for increased renin secretion. Polybrominated Biphenyls 110-113 renin Rattus norvegicus 215-220 3060354-2 1988 In rats, when lead exposure is begun several weeks after birth in doses that cause blood lead concentrations (PbB) of 30 to 40 micrograms/dL, the result is an increase in basal plasma renin activity (PRA) and renal renin concentration, with no change in the metabolic clearance of renin; this is presumptive evidence for increased renin secretion. Polybrominated Biphenyls 110-113 renin Rattus norvegicus 215-220 2840235-10 1988 Components of the renin-angiotensin-aldosterone system and 18-hydroxydeoxycorticosterone tended to decrease with NaCl, but not with mineral water. Sodium Chloride 113-117 renin Rattus norvegicus 18-23 3292414-0 1988 Effects of the renin inhibitor A-64662 in monkeys and rats with varying baseline plasma renin activity. enalkiren 31-38 renin Rattus norvegicus 15-20 3292414-1 1988 The efficacy of the potent, primate selective renin inhibitor A-64662 was studied in monkeys and rats with varying baseline plasma renin activity (PRA) to elucidate the relationship between PRA and the hypotensive response induced by this compound. enalkiren 62-69 renin Rattus norvegicus 46-51 3134306-6 1988 Oral administration of ES 6864 also produced dose-related decreases of blood pressure in hog renin-infused rats, but the duration of action was much shorter than that in conscious marmosets. ES 6864 23-30 renin Rattus norvegicus 93-98 3194576-0 1988 [Is the renin-angiotensin system implicated in the hypertensive effect of a water-soluble tissue extract?]. Water 76-81 renin Rattus norvegicus 8-13 2972033-0 1988 Atrial natriuretic peptide, arginine vasopressin, and the renin-angiotensin system in carbon tetrachloride-induced hepatitis in rats. Carbon Tetrachloride 86-106 renin Rattus norvegicus 58-63 3041306-1 1988 During an investigation of the role of the mediobasal hypothalamus in the regulation of renin secretion from the kidneys, we found that lesions of the ventromedial nuclei prevented the increase in plasma renin activity produced by p-chloroamphetamine. p-Chloroamphetamine 231-250 renin Rattus norvegicus 88-93 3041306-1 1988 During an investigation of the role of the mediobasal hypothalamus in the regulation of renin secretion from the kidneys, we found that lesions of the ventromedial nuclei prevented the increase in plasma renin activity produced by p-chloroamphetamine. p-Chloroamphetamine 231-250 renin Rattus norvegicus 204-209 3041306-4 1988 The plasma renin concentration responses to immobilization and a low-sodium diet were also reduced. Sodium 69-75 renin Rattus norvegicus 11-16 3354659-4 1988 Stimulation of renin substrate by nephrectomy and dexamethasone administration were additive. Dexamethasone 50-63 renin Rattus norvegicus 15-20 3385205-7 1988 Chronic immunosuppressive therapy with cyclophosphamide at most only attenuated the development of renal infarct hypertension associated with this transient renin elevation. Cyclophosphamide 39-55 renin Rattus norvegicus 157-162 3385207-2 1988 This study was undertaken to determine the hypotensive effect of magnesium administration in relation to the state of activation of the renin-angiotensin system. Magnesium 65-74 renin Rattus norvegicus 136-141 3385207-3 1988 The mean blood pressure (MBP) and heart rate (HR) response to either the acute intravenous administration of a pharmacological dose of MgSO4 or vehicle was determined in conscious mineralocorticoid-salt (DOCA-salt, low-renin) and two-kidney, one clip renovascular, high-renin hypertensive rats. Magnesium Sulfate 135-140 renin Rattus norvegicus 219-224 3385207-3 1988 The mean blood pressure (MBP) and heart rate (HR) response to either the acute intravenous administration of a pharmacological dose of MgSO4 or vehicle was determined in conscious mineralocorticoid-salt (DOCA-salt, low-renin) and two-kidney, one clip renovascular, high-renin hypertensive rats. Magnesium Sulfate 135-140 renin Rattus norvegicus 270-275 3385207-7 1988 We conclude that the blood pressure lowering effect of Mg is related, in part, to the state of activation of the renin-angiotensin system. Magnesium 55-57 renin Rattus norvegicus 113-118 3292818-0 1988 Cyclosporine A enhances renin secretion and production in isolated juxtaglomerular cells. Cyclosporine 0-14 renin Rattus norvegicus 24-29 3292818-1 1988 Stimulation of the renin-angiotensin system is a major side effect of the fungoid immunosuppressant cyclosporine A (CyA). Cyclosporine 100-114 renin Rattus norvegicus 19-24 3292818-1 1988 Stimulation of the renin-angiotensin system is a major side effect of the fungoid immunosuppressant cyclosporine A (CyA). Cyclosporine 116-119 renin Rattus norvegicus 19-24 3292818-7 1988 Our results indicate that cyclosporine A stimulates renin secretion and renin synthesis by a direct effect on renal juxtaglomerular cells. Cyclosporine 26-40 renin Rattus norvegicus 52-57 3292818-7 1988 Our results indicate that cyclosporine A stimulates renin secretion and renin synthesis by a direct effect on renal juxtaglomerular cells. Cyclosporine 26-40 renin Rattus norvegicus 72-77 3383998-11 1988 The anti-hypertensive effect was potentiated significantly in hydrochlorothiazide-pretreated SHR when the plasma renin activity was increased. Hydrochlorothiazide 62-81 renin Rattus norvegicus 113-118 2831030-4 1988 In the superfusion system of kidney slices, isoproterenol (5 x 10(-8) M) clearly stimulated renin release from kidney slices, while angiotensin II (AII; 10(-5) M) suppressed renin release. Isoproterenol 44-57 renin Rattus norvegicus 92-97 2831030-7 1988 The superfusion system of juxtaglomerular cells demonstrated greater sensitivity of renin release in responses to isoproterenol and AII. Isoproterenol 114-127 renin Rattus norvegicus 84-89 2831030-10 1988 Similarly, 8 bromo-cGMP (10(-6) M) did not inhibit, but, rather, stimulated basal renin release slightly. 8-bromocyclic GMP 11-23 renin Rattus norvegicus 82-87 3045293-0 1988 Effect of sodium intake on urinary renin excretion in rats. Sodium 10-16 renin Rattus norvegicus 35-40 3045293-1 1988 The present study was carried out to investigate the effect of sodium intake on urinary renin excretion in rats. Sodium 63-69 renin Rattus norvegicus 88-93 3045293-4 1988 Low sodium intake for 4 weeks resulted in a 16-fold increase in urinary renin excretion and led to a 15-fold increase in plasma renin activity. Sodium 4-10 renin Rattus norvegicus 72-77 3045293-4 1988 Low sodium intake for 4 weeks resulted in a 16-fold increase in urinary renin excretion and led to a 15-fold increase in plasma renin activity. Sodium 4-10 renin Rattus norvegicus 128-133 3045293-6 1988 In contrast, high sodium intake for 4 weeks decreased urinary renin excretion, plasma renin activity and renal renin content to about 20%, 25% and 35% of the control level, respectively. Sodium 18-24 renin Rattus norvegicus 62-67 3045293-6 1988 In contrast, high sodium intake for 4 weeks decreased urinary renin excretion, plasma renin activity and renal renin content to about 20%, 25% and 35% of the control level, respectively. Sodium 18-24 renin Rattus norvegicus 86-91 3045293-6 1988 In contrast, high sodium intake for 4 weeks decreased urinary renin excretion, plasma renin activity and renal renin content to about 20%, 25% and 35% of the control level, respectively. Sodium 18-24 renin Rattus norvegicus 86-91 3045293-8 1988 The molecular weight of renin in the urine from rats on low or high sodium intake was 40,000, the value being identical with that from control rats. Sodium 68-74 renin Rattus norvegicus 24-29 3126033-4 1988 12-Hydroperoxyeicosatetraenoic acid and its stable metabolite 12-hydroxyacid mimicked the inhibitory actions of AII on renin. 12-HPETE 0-35 renin Rattus norvegicus 119-124 3126033-4 1988 12-Hydroperoxyeicosatetraenoic acid and its stable metabolite 12-hydroxyacid mimicked the inhibitory actions of AII on renin. 12-hydroxyacid 62-76 renin Rattus norvegicus 119-124 2453748-13 1988 The latter property, together with the activation of the renin-angiotensin system, appears to be responsible for the development of tolerance to the fenoldopam evoked-hypotension. Fenoldopam 149-159 renin Rattus norvegicus 57-62 3130152-4 1988 The captopril-treated rats had a significant elevation in serum renin activity at 12 weeks of age indicating the presence of chronic converting enzyme inhibition, and the 6-OHDA-treatment resulted in a depletion of hypothalamic (86%) and brainstem (76%) norepinephrine content. Captopril 4-13 renin Rattus norvegicus 64-69 3348423-4 1988 Plasma renin concentration was suppressed in the sodium-loaded controls. Sodium 49-55 renin Rattus norvegicus 7-12 3126671-7 1988 Pretreatment with indomethacin (5 mg) prevented the increase in plasma renin activity as well as plasma catecholamine levels. Indomethacin 18-30 renin Rattus norvegicus 71-76 3395464-6 1988 These results provide further documentation for the role of the renin-angiotensin system in modulating alcohol intake. Alcohols 103-110 renin Rattus norvegicus 64-69 3287209-5 1988 Renin (5 mU), injected into the preoptic area, elicited a marked increase in the intake of water and salt, which lasted for about 3 days. Water 91-96 renin Rattus norvegicus 0-5 3288690-4 1988 Administration of 1 mg/kg of hydralazine to the control rats caused mean arterial pressure to fall from 120 +/- 2 mm Hg to 84 +/- 2 mm Hg and elicited an 11.2-fold increase in plasma renin activity and a 2.7-fold increase in plasma norepinephrine concentration. Hydralazine 29-40 renin Rattus norvegicus 183-188 3288690-6 1988 However, administration of 1 mg/kg of hydralazine to the lesion group caused arterial pressure to fall from 128 +/- 6 mm Hg to 64 +/- 2 mm Hg, in association with a 12.4-fold increase in plasma renin activity and a 1.6-fold elevation in plasma norepinephrine concentration. Hydralazine 38-49 renin Rattus norvegicus 194-199 3288690-7 1988 Atenolol, a beta 1-adrenoceptor antagonist, blocked 70% of the rise in plasma renin activity caused by 1 mg/kg of hydralazine in both groups of rats. Atenolol 0-8 renin Rattus norvegicus 78-83 3288690-7 1988 Atenolol, a beta 1-adrenoceptor antagonist, blocked 70% of the rise in plasma renin activity caused by 1 mg/kg of hydralazine in both groups of rats. Hydralazine 114-125 renin Rattus norvegicus 78-83 3288690-8 1988 In addition, prior renal denervation also markedly attenuated the rise in plasma renin activity caused by hydralazine in the lesion group. Hydralazine 106-117 renin Rattus norvegicus 81-86 3287209-0 1988 Gamma-aminobutyric acid and taurine antagonize the central effects of angiotensin II and renin on the intake of water and salt, and on blood pressure in rats. gamma-Aminobutyric Acid 0-23 renin Rattus norvegicus 89-94 3287209-0 1988 Gamma-aminobutyric acid and taurine antagonize the central effects of angiotensin II and renin on the intake of water and salt, and on blood pressure in rats. Taurine 28-35 renin Rattus norvegicus 89-94 3287209-0 1988 Gamma-aminobutyric acid and taurine antagonize the central effects of angiotensin II and renin on the intake of water and salt, and on blood pressure in rats. Water 112-117 renin Rattus norvegicus 89-94 3287209-5 1988 Renin (5 mU), injected into the preoptic area, elicited a marked increase in the intake of water and salt, which lasted for about 3 days. Salts 101-105 renin Rattus norvegicus 0-5 3287209-0 1988 Gamma-aminobutyric acid and taurine antagonize the central effects of angiotensin II and renin on the intake of water and salt, and on blood pressure in rats. Salts 122-126 renin Rattus norvegicus 89-94 3287209-6 1988 The effect of renin was inhibited by [Sar1, Ile8]-angiotensin II (10 micrograms) and was eliminated by captopril (25 micrograms) injected into the preoptic area. Captopril 103-112 renin Rattus norvegicus 14-19 3362940-1 1988 The voluntary intake of alcohol has been shown to be attenuated by a variety of manipulations which increase activity in the renin-angiotensin system. Alcohols 24-31 renin Rattus norvegicus 125-130 3287209-8 1988 The effect of renin was also inhibited by GABA, muscimol or taurine injected into the cerebroventricle, in larger doses, or into the preoptic area in smaller doses. gamma-Aminobutyric Acid 42-46 renin Rattus norvegicus 14-19 3287209-8 1988 The effect of renin was also inhibited by GABA, muscimol or taurine injected into the cerebroventricle, in larger doses, or into the preoptic area in smaller doses. Muscimol 48-56 renin Rattus norvegicus 14-19 3287209-8 1988 The effect of renin was also inhibited by GABA, muscimol or taurine injected into the cerebroventricle, in larger doses, or into the preoptic area in smaller doses. Taurine 60-67 renin Rattus norvegicus 14-19 3078272-0 1988 Angiotensins II and III prevent captopril-induced renin release in the rat. Captopril 32-41 renin Rattus norvegicus 50-55 2831078-1 1988 The influence of the renin-angiotensin system on renal hemodynamics, tubular pressure and tubulo-glomerular feedback was investigated with the angiotensin converting enzyme inhibitor MK 421 (enalapril), in uninephrectomized rats with and without ischemia-induced acute renal failure. Enalapril 191-200 renin Rattus norvegicus 21-26 2831750-3 1988 In recent years, we have demonstrated that manipulating activity in the renin-angiotensin system will dramatically alter voluntary alcohol consumption in rats. Alcohols 131-138 renin Rattus norvegicus 72-77 3078272-3 1988 on plasma renin release following captopril injection (5 mg/kg, i.v.) Captopril 34-43 renin Rattus norvegicus 10-15 3078272-4 1988 were studied in anaesthetized Sprague-Dawley rats, to determine whether angiotensin II blockade is the major mechanism by which captopril induces renin release. Captopril 128-137 renin Rattus norvegicus 146-151 3078272-6 1988 Captopril produced a 12-fold increase in plasma renin concentration compared with saline-injected controls. Captopril 0-9 renin Rattus norvegicus 48-53 2831144-8 1988 These results suggest that chronic intracerebroventricular administration of captopril, through blockade of the brain renin-angiotensin system, alters the hormonal response of SHR to stress. Captopril 77-86 renin Rattus norvegicus 118-123 3078272-15 1988 These findings suggest that captopril induces renin release by inhibiting angiotensin II feedback control of renin secretion and that angiotensin III may also modulate renin release. Captopril 28-37 renin Rattus norvegicus 46-51 3346056-13 1988 Intracisternal administration of 5,7-dihydroxytryptamine produced a hypotensive effect in normal rats and several modifications of the renin-angiotensin complex, suggesting a relationship between the monoaminergic and peptidergic systems. 5,7-Dihydroxytryptamine 33-56 renin Rattus norvegicus 135-140 3078272-15 1988 These findings suggest that captopril induces renin release by inhibiting angiotensin II feedback control of renin secretion and that angiotensin III may also modulate renin release. Captopril 28-37 renin Rattus norvegicus 109-114 3078272-15 1988 These findings suggest that captopril induces renin release by inhibiting angiotensin II feedback control of renin secretion and that angiotensin III may also modulate renin release. Captopril 28-37 renin Rattus norvegicus 109-114 2852078-3 1988 Enalapril caused a marked increase in renin release and synthesis. Enalapril 0-9 renin Rattus norvegicus 38-43 2827530-6 1988 Thyroid treatment tended to decrease the isoproterenol-induced renin release in food-deprived rats and increase the response in the control rats. Isoproterenol 41-54 renin Rattus norvegicus 63-68 2827530-7 1988 These results suggest that the relative hypothyroid state observed in the food-deprived rat may be responsible for the increased concentration of renal beta-receptors and the associated activation of the renin-angiotensin system, which may be partially responsible for the observed increased dipsogenic response induced by isoproterenol. Isoproterenol 323-336 renin Rattus norvegicus 204-209 2892427-3 1988 Interruption of the renin-angiotensin system with the converting enzyme inhibitor captopril or the receptor antagonist saralasin significantly attenuated the pressor responses to adrenal stimulation and injected epinephrine to an equivalent extent. Captopril 82-91 renin Rattus norvegicus 20-25 2892427-3 1988 Interruption of the renin-angiotensin system with the converting enzyme inhibitor captopril or the receptor antagonist saralasin significantly attenuated the pressor responses to adrenal stimulation and injected epinephrine to an equivalent extent. Epinephrine 212-223 renin Rattus norvegicus 20-25 3066529-3 1988 Testosterone (T) is known to raise blood pressure in female and castrated male SH-rats, while concomitantly increasing tissue renin activities. Testosterone 0-12 renin Rattus norvegicus 126-131 3066529-4 1988 The availability of recombinant DNA technology and of a 32P labeled mouse submandibular gland renin cRNA as a hybridization probe enabled us to quantitatively assess whether this increase is paralleled by enhanced renin gene expression. Phosphorus-32 56-59 renin Rattus norvegicus 94-99 3066529-5 1988 In groups of female NMRI mice injected with DHT, we were able to show, that cardiac renin activity was significantly increased after 2 hours (1.6 fold) and 21 days (1.9 fold) of dihydrotestosterone (DHT) treatment compared to controls. Dihydrotestosterone 44-47 renin Rattus norvegicus 84-89 3066529-5 1988 In groups of female NMRI mice injected with DHT, we were able to show, that cardiac renin activity was significantly increased after 2 hours (1.6 fold) and 21 days (1.9 fold) of dihydrotestosterone (DHT) treatment compared to controls. Dihydrotestosterone 178-197 renin Rattus norvegicus 84-89 3066529-5 1988 In groups of female NMRI mice injected with DHT, we were able to show, that cardiac renin activity was significantly increased after 2 hours (1.6 fold) and 21 days (1.9 fold) of dihydrotestosterone (DHT) treatment compared to controls. Dihydrotestosterone 199-202 renin Rattus norvegicus 84-89 2852075-2 1988 We have studied the regulation of renin gene expression in the fetus and also in the adult rat in response to angiotensin converting enzyme (ACE) inhibition with enalapril in the presence and absence of angiotensin II (AII). Enalapril 162-171 renin Rattus norvegicus 34-39 2852075-8 1988 Utilizing this method, we have demonstrated that ACE inhibition with enalapril increases the number of renin secreting cells by over 15-fold at physiologic calcium concentrations. Enalapril 69-78 renin Rattus norvegicus 103-108 2852078-4 1988 AII abolished the rise in plasma and renal renin observed with Enalapril. Enalapril 63-72 renin Rattus norvegicus 43-48 2852075-8 1988 Utilizing this method, we have demonstrated that ACE inhibition with enalapril increases the number of renin secreting cells by over 15-fold at physiologic calcium concentrations. Calcium 156-163 renin Rattus norvegicus 103-108 2852079-0 1988 Effect of a single dose of enalapril on renin gene expression in the kidney and angiotensinogen gene expression in the liver of rats. Enalapril 27-36 renin Rattus norvegicus 40-45 2852075-9 1988 Enalapril also induced a 3-fold increase in the amount of renin released as estimated by the area of the hemolytic plaques formed. Enalapril 0-9 renin Rattus norvegicus 58-63 3141091-3 1988 Ether, Innovar and Nembutal increased active plasma renin and had variable effects on the inactive form of the enzyme. Ether 0-5 renin Rattus norvegicus 52-57 3141091-3 1988 Ether, Innovar and Nembutal increased active plasma renin and had variable effects on the inactive form of the enzyme. Pentobarbital 19-27 renin Rattus norvegicus 52-57 2852080-4 1988 These results indicate that the pressor responses to sodium salts are mediated via inhibition of the brain Na+, K+-ATPase, and that the brain renin-ang system is involved in this mechanism. sodium salts 53-65 renin Rattus norvegicus 142-147 3141091-4 1988 Only Innovar, a combination of droperidol and fentanyl, increased aortic renin. Droperidol 31-41 renin Rattus norvegicus 73-78 3286067-1 1988 A genomic renin exon 9 fragment was subcloned into vector pSPT18 and used for in vitro transcription to obtain 32P-labeled rat renin cRNA. Phosphorus-32 111-114 renin Rattus norvegicus 10-15 3286067-1 1988 A genomic renin exon 9 fragment was subcloned into vector pSPT18 and used for in vitro transcription to obtain 32P-labeled rat renin cRNA. Phosphorus-32 111-114 renin Rattus norvegicus 127-132 3141091-4 1988 Only Innovar, a combination of droperidol and fentanyl, increased aortic renin. Fentanyl 46-54 renin Rattus norvegicus 73-78 2852080-6 1988 Since pressor responses to intracerebroventricular (ICV) infusions of hypertonic NaCl are abolished with ICV pretreatment with ang II blockers, a brain renin-ang system may be involved in this mechanism. Sodium Chloride 81-85 renin Rattus norvegicus 152-157 3141091-5 1988 The active component of Innovar was shown to be droperidol, which also increased aortic renin in 24 hour nephrectomized animals. Droperidol 48-58 renin Rattus norvegicus 88-93 3141091-7 1988 The increase of tissue renin following droperidol was rapid, suggesting activation of an inactive tissue renin. Droperidol 39-49 renin Rattus norvegicus 23-28 2977978-1 1988 Prolonged (12-day) sodium deprivation strikingly raised both basal plasma aldosterone concentration (PAC) (114%) and plasma renin activity (PRA) (200%), and lowered ANF blood level (-30%). Sodium 19-25 renin Rattus norvegicus 124-129 3141091-7 1988 The increase of tissue renin following droperidol was rapid, suggesting activation of an inactive tissue renin. Droperidol 39-49 renin Rattus norvegicus 105-110 3276572-1 1988 Renin (1 ng) was injected into the 3rd ventricle of the brain of rat pups at various ages, and their ingestion was measured by weighing them either after 40 min of oral infusion of water or milk while they were away from their dam (off-dam), or after 40 min of suckling from their dams (on-dam). Water 181-186 renin Rattus norvegicus 0-5 3276572-5 1988 These findings reveal that the adult characteristics of the dipsogenic action of the renin-angiotensin system in the brain emerge at 15 days, at which age the increased intake becomes entirely specific for water. Water 206-211 renin Rattus norvegicus 85-90 2448241-2 1988 Tonin-alpha 1-macroglobulin complex, which was immunologically immobilized by anti-alpha 1-macroglobulin antibody covalently coupled to agarose gels, could quantitatively hydrolyze angiotensin I and synthetic tridecapeptide renin substrate to form angiotensin II. Sepharose 136-143 renin Rattus norvegicus 224-229 3068096-0 1988 Acute effect of potassium canrenoate administration on renin-angiotensin, kallikrein-kinin and prostaglandin systems. Canrenoic Acid 16-36 renin Rattus norvegicus 55-60 3275771-2 1988 In addition, we have studied its antihypertensive effect in the awake renal artery-ligated rat, whose elevated levels of plasma renin activity and sensitivity to captopril and saralasin define it as a renin-angiotensin system-dependent hypertensive model. Captopril 162-171 renin Rattus norvegicus 201-206 2450260-2 1988 The RRM-salt was characterized by: (1) increased endogenous "digitalis-like" compounds in plasma [cross reactivity with digoxin-antibodies (57.5 +/- 5.0 vs. 42.1 +/- 3.8 pg/ml, p less than 0.02); inhibition of kidney Na+, K+-ATPase activity (135 +/- 5 vs. 154 +/- 5 mumol/mg/h, p less than 0.01); and inhibition of Na+ extrusion from normal erythrocytes (5.96 +/- 0.40 vs. 7.68 +/- 0.34 mmol/L cells/h, p less than 0.01)]; (2) reduced Na+, K+-pump activity (7.34 +/- 0.29 vs. 10.88 +/- 0.41 mmol/L cells/h, p less than 0.001) and increased Na+ content (4.66 +/- .08 vs. 4.16 +/- 0.11 mmol/L cells, p less than 0.01) in erythrocytes; and (3) low plasma renin activity (2.1 +/- 0.9 vs. 12.6 +/- 1.6 ng/ml/h). Salts 8-12 renin Rattus norvegicus 652-657 3057301-1 1988 The interaction of prostaglandin (PG) with the vascular renin-angiotensin (R-A) system was examined by studies on the effects of PGI2, PGE2 and the inhibitor of PG synthesis, indomethacin, on the release of angiotensin II (Ang II) from isolated rat mesenteric arteries. Prostaglandins 34-36 renin Rattus norvegicus 56-61 3057301-0 1988 Effect of vasodilator prostaglandins on the vascular renin-angiotensin system. Prostaglandins 22-36 renin Rattus norvegicus 53-58 3282117-0 1988 [Effect of captopril on arterial pressure, systemic hemodynamics and renin activity in the blood plasma of rats with spontaneous hypertension]. Captopril 11-20 renin Rattus norvegicus 69-74 3282117-4 1988 Captopril considerably increased plasma renin activity in NR and SHR. Captopril 0-9 renin Rattus norvegicus 40-45 3057301-6 1988 Infusion of PGI2 (10(-6) M) significantly decreased both Ang II release (p less than 0.01) and vascular renin activity (p less than 0.05) as compared with the control levels. Epoprostenol 12-16 renin Rattus norvegicus 104-109 3057301-1 1988 The interaction of prostaglandin (PG) with the vascular renin-angiotensin (R-A) system was examined by studies on the effects of PGI2, PGE2 and the inhibitor of PG synthesis, indomethacin, on the release of angiotensin II (Ang II) from isolated rat mesenteric arteries. Prostaglandins 19-32 renin Rattus norvegicus 56-61 3057301-7 1988 Infusion of PGE2 (10(-6) M) decreased Ang II release significantly (p less than 0.05) and vascular renin activity slightly. Dinoprostone 12-16 renin Rattus norvegicus 99-104 3057301-8 1988 Infusion of indomethacin (10(-6)M) increased vascular renin activity significantly (p less than 0.01). Indomethacin 12-24 renin Rattus norvegicus 54-59 3057301-9 1988 Pretreatment with indomethacin (10 mg/kg, ip) for 2 days also increased vascular renin activity (p less than 0.01). Indomethacin 18-30 renin Rattus norvegicus 81-86 3285225-0 1988 The mechanism of yohimbine-induced renin release in the conscious rat. Yohimbine 17-26 renin Rattus norvegicus 35-40 3285225-1 1988 These studies were designed to determine the role of the central nervous system, the sympathetic nervous system, the adrenal glands and the renal sympathetic nerves in yohimbine-induced renin release in conscious rats. Yohimbine 168-177 renin Rattus norvegicus 186-191 3285225-2 1988 Yohimbine (0.3-10 mg/kg, s.c.) caused time- and dose-related increases in plasma renin activity (PRA) and concentration (PRC) which were accompanied by time- and dose-related elevations of plasma norepinephrine (NE) and epinephrine (Epi) concentrations. Yohimbine 0-9 renin Rattus norvegicus 81-86 3285225-3 1988 Significant positive correlations were found between the increases in PRA and the increases in plasma NE and Epi concentrations caused by yohimbine, and propranolol (1.5 mg/kg, s.c.) blocked 90% of yohimbine (3 mg/kg, s.c.)-induced renin release. Propranolol 153-164 renin Rattus norvegicus 232-237 3285225-6 1988 An increase in circulating plasma catecholamine concentrations appeared to mediate yohimbine-induced renin release since propranolol prevented the rise in PRA caused by yohimbine in renal denervated rats. Catecholamines 34-47 renin Rattus norvegicus 101-106 3285225-6 1988 An increase in circulating plasma catecholamine concentrations appeared to mediate yohimbine-induced renin release since propranolol prevented the rise in PRA caused by yohimbine in renal denervated rats. Yohimbine 83-92 renin Rattus norvegicus 101-106 3285225-6 1988 An increase in circulating plasma catecholamine concentrations appeared to mediate yohimbine-induced renin release since propranolol prevented the rise in PRA caused by yohimbine in renal denervated rats. Propranolol 121-132 renin Rattus norvegicus 101-106 3285225-11 1988 Based on these results, we conclude that 1) the stimulation of renin release by yohimbine is a secondary neurohormonal consequence of the generalized increase in sympathetic activity caused by yohimbine, 2) the sympathoadrenal activation produced by yohimbine results from an action in the brain which is amplified by the simultaneous blockade of prejunctional alpha 2-adrenoceptors. Yohimbine 80-89 renin Rattus norvegicus 63-68 3285225-11 1988 Based on these results, we conclude that 1) the stimulation of renin release by yohimbine is a secondary neurohormonal consequence of the generalized increase in sympathetic activity caused by yohimbine, 2) the sympathoadrenal activation produced by yohimbine results from an action in the brain which is amplified by the simultaneous blockade of prejunctional alpha 2-adrenoceptors. Yohimbine 193-202 renin Rattus norvegicus 63-68 3285225-11 1988 Based on these results, we conclude that 1) the stimulation of renin release by yohimbine is a secondary neurohormonal consequence of the generalized increase in sympathetic activity caused by yohimbine, 2) the sympathoadrenal activation produced by yohimbine results from an action in the brain which is amplified by the simultaneous blockade of prejunctional alpha 2-adrenoceptors. Yohimbine 193-202 renin Rattus norvegicus 63-68 2854904-1 1988 Because adenosine plays a role in the regulation of glomerular filtration rate and of the release of renin, we examined the possibility of a local source for this mediator. Adenosine 8-17 renin Rattus norvegicus 101-106 2447462-5 1987 Canrenone, a metabolic product of spironolactone which can compete with oubain for binding to Na+,K+-ATPase at the digitalis receptor site, decreases blood pressure in a low renin, volume expanded model of hypertension which has been shown to have depressed sodium pump activity in arteries and increased sodium pump inhibitor in plasma (reduced renal mass-saline rat) but has no effect on blood pressure in a genetic model of hypertension which has been shown to have increased sodium pump activity secondary to increased sodium permeability (spontaneously hypertensive rat). Canrenone 0-9 renin Rattus norvegicus 174-179 3328570-9 1987 In conclusion, occupation of adenosine receptors can lead either to inhibition (A1 receptor-mediated) or stimulation (A2 receptor-mediated) of renin secretion, and XAC is a very potent and selective antagonist of CHA-induced changes in renin secretion. Xanthine amine congener 164-167 renin Rattus norvegicus 236-241 3322039-2 1987 In the present study, light and electron microscope autoradiography of intravenously administered 125I-labeled rat renal renin was performed in rat liver and kidney to observe the cellular and subcellular distribution of the renin. Iodine-125 98-102 renin Rattus norvegicus 121-126 3322039-2 1987 In the present study, light and electron microscope autoradiography of intravenously administered 125I-labeled rat renal renin was performed in rat liver and kidney to observe the cellular and subcellular distribution of the renin. Iodine-125 98-102 renin Rattus norvegicus 225-230 3322039-9 1987 These results, taken together with our previous finding that nonglycosylated submaxillary renin does not distribute in the liver, suggest that the carbohydrate moieties of renal renin are necessary for the recognition by Kupffer cells. Carbohydrates 147-159 renin Rattus norvegicus 90-95 3322039-9 1987 These results, taken together with our previous finding that nonglycosylated submaxillary renin does not distribute in the liver, suggest that the carbohydrate moieties of renal renin are necessary for the recognition by Kupffer cells. Carbohydrates 147-159 renin Rattus norvegicus 178-183 3055814-0 1988 [Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats]. puerarin 12-20 renin Rattus norvegicus 50-55 3328570-0 1987 XAC, a functionalized congener of 1,3-dialkylxanthine, antagonizes A1 adenosine receptor-mediated inhibition of renin secretion in vitro. Xanthine amine congener 0-3 renin Rattus norvegicus 112-117 3328570-0 1987 XAC, a functionalized congener of 1,3-dialkylxanthine, antagonizes A1 adenosine receptor-mediated inhibition of renin secretion in vitro. 1,3-dialkylxanthine 34-53 renin Rattus norvegicus 112-117 3328570-3 1987 N6-cyclohexyladenosine (CHA) had a biphasic effect on renin secretion: submicromolar concentrations inhibited concentration-dependently, and there was an inflection in the dose-response curve near 1 microM CHA such that higher concentrations produced a concentration-dependent relative stimulation, which became an absolute stimulation (i.e., secretory rate was higher than control) at 50 microM. N(6)-cyclohexyladenosine 0-22 renin Rattus norvegicus 54-59 3328570-3 1987 N6-cyclohexyladenosine (CHA) had a biphasic effect on renin secretion: submicromolar concentrations inhibited concentration-dependently, and there was an inflection in the dose-response curve near 1 microM CHA such that higher concentrations produced a concentration-dependent relative stimulation, which became an absolute stimulation (i.e., secretory rate was higher than control) at 50 microM. N(6)-cyclohexyladenosine 24-27 renin Rattus norvegicus 54-59 2828468-9 1987 Similarly, plasma renin activity returned to baseline in atenolol-treated animals. Atenolol 57-65 renin Rattus norvegicus 18-23 3328570-6 1987 It antagonized both CHA-induced inhibition (Ki approximately 2 x 10(-9) M) and CHA-induced stimulation (Ki approximately 5 x 10(-8) M) of renin secretion. N(6)-cyclohexyladenosine 79-82 renin Rattus norvegicus 138-143 3328570-7 1987 Thus, XAC exhibited a 25-fold selectivity for CHA-induced inhibition of renin secretion in comparison with CHA-induced stimulation. Xanthine amine congener 6-9 renin Rattus norvegicus 72-77 3328570-7 1987 Thus, XAC exhibited a 25-fold selectivity for CHA-induced inhibition of renin secretion in comparison with CHA-induced stimulation. N(6)-cyclohexyladenosine 46-49 renin Rattus norvegicus 72-77 3320345-0 1987 Activation of serotonin2 (5-HT2) receptors by quipazine increases arterial pressure and renin secretion in conscious rats. Quipazine 46-55 renin Rattus norvegicus 88-93 3320345-1 1987 Quipazine, a nonselective serotonin (5-HT) agonist, has been shown to increase plasma renin activity (PRA). Quipazine 0-9 renin Rattus norvegicus 86-91 3320345-10 1987 Total blockade of quipazine-induced renin secretion was produced by LY 53857 at 0.003 mg/kg, and the response was still reduced by 50% at 0.001 mg/kg. Quipazine 18-27 renin Rattus norvegicus 36-41 3320345-10 1987 Total blockade of quipazine-induced renin secretion was produced by LY 53857 at 0.003 mg/kg, and the response was still reduced by 50% at 0.001 mg/kg. Lysine 68-70 renin Rattus norvegicus 36-41 3320345-12 1987 The 10-fold difference in the dose of LY 53857 necessary to block the pressor and renin responses may be due to subtle differences in receptor subtypes, or to pharmacokinetic properties favoring antagonism of quipazine-induced renin secretion. Lysine 38-40 renin Rattus norvegicus 82-87 3320345-12 1987 The 10-fold difference in the dose of LY 53857 necessary to block the pressor and renin responses may be due to subtle differences in receptor subtypes, or to pharmacokinetic properties favoring antagonism of quipazine-induced renin secretion. Lysine 38-40 renin Rattus norvegicus 227-232 3320345-12 1987 The 10-fold difference in the dose of LY 53857 necessary to block the pressor and renin responses may be due to subtle differences in receptor subtypes, or to pharmacokinetic properties favoring antagonism of quipazine-induced renin secretion. Quipazine 209-218 renin Rattus norvegicus 227-232 3328780-6 1987 Following inhibition of the renin-angiotensin system with captopril or sar-1-ile-8-angiotensin II, brachial nerve stimulation resulted in similar increases in systemic blood pressure and heart rate as in the animals with an intact renin-angiotensin system but, in captopril-infused rats, did not change renal haemodynamics or urine flow while absolute and fractional sodium excretions were reduced by 20 and 25%, respectively. Captopril 58-67 renin Rattus norvegicus 28-33 3688234-3 1987 The maintenance period of chronic CDA, compared with control, was characterized by hypokalemic metabolic alkalosis (serum TCO2 31.9 +/- 0.6 vs. 23.1 +/- 0.5 meq/l, P less than 0.05), volume contraction (plasma volume 3.76 +/- 0.08 vs. 4.19 +/- 0.22 ml/100 g body wt, P less than 0.05), decreased GFR (838 +/- 84 vs. 1045 +/- 45 microliters.min-1.100 g body wt-1, P less than 0.05), increased plasma renin activity (PRA) (63 +/- 13 vs. 12 +/- 3 ng.ml-1.h-1, P less than 0.05), but unchanged plasma aldosterone concentrations (PAC) (4.1 +/- 1.0 vs. 3.4 +/- 1.6 ng/dl, P = NS). cda 34-37 renin Rattus norvegicus 399-404 3318496-0 1987 Control of renin release by dietary NaCl in the rat. Sodium Chloride 36-40 renin Rattus norvegicus 11-16 3318496-1 1987 The purpose of the present study is to determine whether changes of plasma renin activity (PRA) induced by dietary NaCl are mediated by a renal tubular mechanism or by a neural mechanism. Sodium Chloride 115-119 renin Rattus norvegicus 75-80 3318496-8 1987 A vagally mediated mechanism may contribute to renin suppression by dietary NaCl. Sodium Chloride 76-80 renin Rattus norvegicus 47-52 2444536-5 1987 The data are consistent with the postulated inverse relationship between calcium concentration and release of renin. Calcium 73-80 renin Rattus norvegicus 110-115 3318506-6 1987 These results indicate that the previously observed diminished contributions from endogenous vasopressin and the renin-angiotensin system to blood pressure recovery following ganglion blockade in streptozotocin-treated rats may have been due, at least in part, to diminished pressor responsiveness. Streptozocin 196-210 renin Rattus norvegicus 113-118 2824314-5 1987 Administration of captopril, a converting enzyme inhibitor, decreased hepatic extraction of renin by approximately 60%; enalaprilat, another converting enzyme inhibitor, had no effect. Captopril 18-27 renin Rattus norvegicus 92-97 2824314-6 1987 First-pass hepatic extraction of renin was also inhibited by the bile acid, taurocholate, in a dose-dependent manner. Bile Acids and Salts 65-74 renin Rattus norvegicus 33-38 3317383-2 1987 Captopril (100 mg/kg/day for 5 days) decreased systolic blood pressure and increased water consumption, urine excretion and plasma renin activity (PRA). Captopril 0-9 renin Rattus norvegicus 131-136 2824314-6 1987 First-pass hepatic extraction of renin was also inhibited by the bile acid, taurocholate, in a dose-dependent manner. Taurocholic Acid 76-88 renin Rattus norvegicus 33-38 3653966-0 1987 Oral calcium treatment lowers blood pressure in renovascular hypertensive rats by suppressing the renin-angiotensin system. Calcium 5-12 renin Rattus norvegicus 98-103 3653966-5 1987 However, increased plasma renin activity and plasma aldosterone concentration were suppressed to the basal levels at the end of 3 weeks of calcium treatment (14 +/- 3 vs 8 +/- 2 ng angiotensin I/ml/hr; 530 +/- 50 vs 380 +/- 40 pg/ml). Calcium 139-146 renin Rattus norvegicus 26-31 3653966-6 1987 Blood pressure of calcium-treated renovascular hypertensive rats responded poorly to blockade of the renin-angiotensin system with captopril injection and angiotensin II analogue (saralasin) infusion. Calcium 18-25 renin Rattus norvegicus 101-106 3653966-8 1987 These results suggest that the blood pressure-lowering actions of calcium supplementation are related primarily to suppression of renin secretion and secondarily to alteration of pressor response to norepinephrine in two-kidney, one clip renovascular hypertensive rats. Calcium 66-73 renin Rattus norvegicus 130-135 3319038-3 1987 Atenolol reduced the elevated plasma renin activity in the lesion group to a value similar to that of a control group (sham lesions or lesions in areas adjacent to the PBN). Atenolol 0-8 renin Rattus norvegicus 37-42 2957322-4 1987 In addition, nisoldipine had a therapeutic effect in old SHR with manifest cardiac failure in end-stage hypertension, as evidenced not only by the reduction of blood pressure but also by the reduction of cardiac hypertrophy, of elevated immunoreactive ANP in plasma, and of increased plasma renin activity. Nisoldipine 13-24 renin Rattus norvegicus 291-296 3311989-7 1987 Serum renin activity was lower in SHR than in WKY following acute decreases in serum sodium at 8 weeks, but it was the same for both strains at 18 weeks. Sodium 85-91 renin Rattus norvegicus 6-11 3118024-0 1987 Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement. H-LEU-VAL-OH 116-123 renin Rattus norvegicus 80-85 3308700-1 1987 Effects of oral treatment with taurine on fluid intakes produced by renin were assessed in spontaneously hypertensive rats of the Okamoto strain (SHR). Taurine 31-38 renin Rattus norvegicus 68-73 3308700-2 1987 Renin injected into the preoptic area increased water intake and evoked salt (2.7% NaCl solution) intake, and angiotensin II injected into this area increased water intake, but not salt intake, in both SHR and control normotensive Wistar-Kyoto rats (WKY). Water 48-53 renin Rattus norvegicus 0-5 3308700-2 1987 Renin injected into the preoptic area increased water intake and evoked salt (2.7% NaCl solution) intake, and angiotensin II injected into this area increased water intake, but not salt intake, in both SHR and control normotensive Wistar-Kyoto rats (WKY). Salts 72-76 renin Rattus norvegicus 0-5 3308700-3 1987 The salt intake elicited by renin, but not water intake produced by renin or angiotensin II, was potentiated in SHR. Salts 4-8 renin Rattus norvegicus 28-33 3308700-4 1987 These effects of renin and angiotensin II on fluid intakes were antagonized by previous administration of taurine or gamma-aminobutyric acid into the cerebral ventricles in both strains. Taurine 106-113 renin Rattus norvegicus 17-41 3308700-4 1987 These effects of renin and angiotensin II on fluid intakes were antagonized by previous administration of taurine or gamma-aminobutyric acid into the cerebral ventricles in both strains. gamma-Aminobutyric Acid 117-140 renin Rattus norvegicus 17-41 3308700-6 1987 Renin administered into the preoptic area at 105 days of age caused an increase in salt intake, but the increase was markedly inhibited by the oral administration of taurine as well. Salts 83-87 renin Rattus norvegicus 0-5 3308700-6 1987 Renin administered into the preoptic area at 105 days of age caused an increase in salt intake, but the increase was markedly inhibited by the oral administration of taurine as well. Taurine 166-173 renin Rattus norvegicus 0-5 3308700-7 1987 These results show that salt appetite produced by centrally administered renin is exaggerated in SHR and that development of hypertension as well as renin-induced salt appetite in SHR is inhibited by dietary taurine. Salts 24-28 renin Rattus norvegicus 73-78 3308700-7 1987 These results show that salt appetite produced by centrally administered renin is exaggerated in SHR and that development of hypertension as well as renin-induced salt appetite in SHR is inhibited by dietary taurine. Salts 24-28 renin Rattus norvegicus 149-154 3308700-7 1987 These results show that salt appetite produced by centrally administered renin is exaggerated in SHR and that development of hypertension as well as renin-induced salt appetite in SHR is inhibited by dietary taurine. Salts 163-167 renin Rattus norvegicus 149-154 3308700-7 1987 These results show that salt appetite produced by centrally administered renin is exaggerated in SHR and that development of hypertension as well as renin-induced salt appetite in SHR is inhibited by dietary taurine. Taurine 208-215 renin Rattus norvegicus 149-154 2959466-10 1987 The results indirectly show that pCPA-induced suppression of renal renin secretion observed in Wi rats may be due to prevailing inhibitory action of antidiuretic hormone. Fenclonine 33-37 renin Rattus norvegicus 67-72 2955183-6 1987 Similarly, the incubation of the superficial cortical slices with arachidonic acid (10(-3) M) resulted in a 4-fold increase in tissue renin release which was blocked by the calcium ionophore A23187 (17 X 10(-6) M) and ANP; interestingly, DDA did not block arachidonic acid-induced renin release. dda 238-241 renin Rattus norvegicus 134-139 3040809-4 1987 Plasma renin activity (PRA) was highest in the 2K-1C group (6.20 +/- 2.17 ng/ml per h), intermediate in the 1K-1C group (2.19 +/- 0.62 ng/ml per h) and control group (3.20 +/- 0.53 ng/ml per h), and lowest in the DOCA-salt group (0.07 +/- 0.06 ng/ml per h). Desoxycorticosterone Acetate 213-217 renin Rattus norvegicus 7-12 3040809-4 1987 Plasma renin activity (PRA) was highest in the 2K-1C group (6.20 +/- 2.17 ng/ml per h), intermediate in the 1K-1C group (2.19 +/- 0.62 ng/ml per h) and control group (3.20 +/- 0.53 ng/ml per h), and lowest in the DOCA-salt group (0.07 +/- 0.06 ng/ml per h). Salts 218-222 renin Rattus norvegicus 7-12 2955183-4 1987 Renin release was stimulated significantly by the beta-adrenergic agonist isoproterenol in concentrations of 10(-5) M (1.67-fold) and 10(-4) M (1.84-fold). Isoproterenol 74-87 renin Rattus norvegicus 0-5 3322883-9 1987 The molecular weight of inactive renin (51,000) in the normal rat plasma estimated by Sephadex G-100 column (Pharmacia) was the same as that in the nephrectomized rat plasma. sephadex 86-100 renin Rattus norvegicus 33-38 2955183-5 1987 Isoproterenol-induced renin release was inhibited by atriopeptin III (ANP, 2 X 10(-8) M) and the adenylate cyclase inhibitor dideoxadenosine (DDA, 10(-5) M). Isoproterenol 0-13 renin Rattus norvegicus 22-27 2955183-6 1987 Similarly, the incubation of the superficial cortical slices with arachidonic acid (10(-3) M) resulted in a 4-fold increase in tissue renin release which was blocked by the calcium ionophore A23187 (17 X 10(-6) M) and ANP; interestingly, DDA did not block arachidonic acid-induced renin release. Arachidonic Acid 256-272 renin Rattus norvegicus 134-139 2955183-5 1987 Isoproterenol-induced renin release was inhibited by atriopeptin III (ANP, 2 X 10(-8) M) and the adenylate cyclase inhibitor dideoxadenosine (DDA, 10(-5) M). dideoxadenosine 125-140 renin Rattus norvegicus 22-27 2955183-7 1987 These results suggest that ANP exerts a direct inhibitory effect on B-adrenergic and arachidonic acid-induced renin release in the primate kidney. Arachidonic Acid 85-101 renin Rattus norvegicus 110-115 2955183-5 1987 Isoproterenol-induced renin release was inhibited by atriopeptin III (ANP, 2 X 10(-8) M) and the adenylate cyclase inhibitor dideoxadenosine (DDA, 10(-5) M). dda 142-145 renin Rattus norvegicus 22-27 2955183-8 1987 Further, the inhibitory action of A23187 on renin release suggests, as in other species, an integral role for intracellular calcium in the renin release process. Calcimycin 34-40 renin Rattus norvegicus 44-49 2955183-6 1987 Similarly, the incubation of the superficial cortical slices with arachidonic acid (10(-3) M) resulted in a 4-fold increase in tissue renin release which was blocked by the calcium ionophore A23187 (17 X 10(-6) M) and ANP; interestingly, DDA did not block arachidonic acid-induced renin release. Arachidonic Acid 66-82 renin Rattus norvegicus 134-139 2955183-6 1987 Similarly, the incubation of the superficial cortical slices with arachidonic acid (10(-3) M) resulted in a 4-fold increase in tissue renin release which was blocked by the calcium ionophore A23187 (17 X 10(-6) M) and ANP; interestingly, DDA did not block arachidonic acid-induced renin release. Arachidonic Acid 66-82 renin Rattus norvegicus 281-286 2955183-6 1987 Similarly, the incubation of the superficial cortical slices with arachidonic acid (10(-3) M) resulted in a 4-fold increase in tissue renin release which was blocked by the calcium ionophore A23187 (17 X 10(-6) M) and ANP; interestingly, DDA did not block arachidonic acid-induced renin release. Calcium 173-180 renin Rattus norvegicus 134-139 2955183-6 1987 Similarly, the incubation of the superficial cortical slices with arachidonic acid (10(-3) M) resulted in a 4-fold increase in tissue renin release which was blocked by the calcium ionophore A23187 (17 X 10(-6) M) and ANP; interestingly, DDA did not block arachidonic acid-induced renin release. Calcium 173-180 renin Rattus norvegicus 281-286 2955183-6 1987 Similarly, the incubation of the superficial cortical slices with arachidonic acid (10(-3) M) resulted in a 4-fold increase in tissue renin release which was blocked by the calcium ionophore A23187 (17 X 10(-6) M) and ANP; interestingly, DDA did not block arachidonic acid-induced renin release. Calcimycin 191-197 renin Rattus norvegicus 134-139 2955183-6 1987 Similarly, the incubation of the superficial cortical slices with arachidonic acid (10(-3) M) resulted in a 4-fold increase in tissue renin release which was blocked by the calcium ionophore A23187 (17 X 10(-6) M) and ANP; interestingly, DDA did not block arachidonic acid-induced renin release. Calcimycin 191-197 renin Rattus norvegicus 281-286 2955183-8 1987 Further, the inhibitory action of A23187 on renin release suggests, as in other species, an integral role for intracellular calcium in the renin release process. Calcimycin 34-40 renin Rattus norvegicus 139-144 2955183-8 1987 Further, the inhibitory action of A23187 on renin release suggests, as in other species, an integral role for intracellular calcium in the renin release process. Calcium 124-131 renin Rattus norvegicus 139-144 3477616-0 1987 Stimulation of brain and aortic renin substrate by central administration of steroids in the rat. Steroids 77-85 renin Rattus norvegicus 32-37 3300372-8 1987 They also suggest that the serotonergic pathway does mediate the increases in renin secretion produced by immobilization, head-up tilt, and a low-sodium diet. Sodium 146-152 renin Rattus norvegicus 78-83 2821205-7 1987 Following nifedipine treatment, specific renin-like activities increased in all cardiac structures studied (P less than 0.01); with nitrendipine and muzolimine less pronounced elevations were obtained. Nifedipine 10-20 renin Rattus norvegicus 41-46 2821207-4 1987 The renin system was inhibited in two groups of SHR by giving them enalapril to determine whether angiotensin II was involved in blood-vessel adaptation. Enalapril 67-76 renin Rattus norvegicus 4-9 2821208-6 1987 Angiotensin I-forming angiotensinogenase activity was increased following treatment with nifedipine (P less than 0.01) but reduced by nitrendipine (P less than 0.05); with muzolimine, no significant alterations were observed. Nifedipine 89-99 renin Rattus norvegicus 22-40 2821208-6 1987 Angiotensin I-forming angiotensinogenase activity was increased following treatment with nifedipine (P less than 0.01) but reduced by nitrendipine (P less than 0.05); with muzolimine, no significant alterations were observed. Nitrendipine 134-146 renin Rattus norvegicus 22-40 3301666-1 1987 Adenosine may be a physiological modulator of vascular smooth muscle tone, sympathetic neurotransmission, renin release, and renal and cardiac function. Adenosine 0-9 renin Rattus norvegicus 106-111 3301666-7 1987 Given the known effects of adenosine on renin release, these data support a role for endogenous adenosine as a regulator of renin release in renovascular hypertension. Adenosine 96-105 renin Rattus norvegicus 40-45 3301666-7 1987 Given the known effects of adenosine on renin release, these data support a role for endogenous adenosine as a regulator of renin release in renovascular hypertension. Adenosine 96-105 renin Rattus norvegicus 124-129 3037924-7 1987 However, by maintaining increased vasoconstriction at reduced RPP, prostaglandin-dependent renin release reduces autoregulatory efficiency in the young rat. Prostaglandins 67-80 renin Rattus norvegicus 91-96 3298043-3 1987 Prostacyclin, at concentrations of 10(-5) M, stimulated renin secretion, but this effect was short-lived. Epoprostenol 0-12 renin Rattus norvegicus 56-61 3298043-5 1987 In contrast, 10(-9) M 12-hydroperoxyeicosatetraenoic acid and 10(-8) M 12-hydroxyeicosatetraenoic acid were potent inhibitors of renin secretion. 12-HPETE 22-57 renin Rattus norvegicus 129-134 3298043-5 1987 In contrast, 10(-9) M 12-hydroperoxyeicosatetraenoic acid and 10(-8) M 12-hydroxyeicosatetraenoic acid were potent inhibitors of renin secretion. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 71-102 renin Rattus norvegicus 129-134 3298043-6 1987 Similarly, 15-hydroperoxyeicosatetraenoic acid and its hydroxy derivative, 15-hydroxyeicosatetraenoic acid, at somewhat higher molar concentrations (10(-6) M) also reduced basal renin. 15-hydroperoxyeicosatetraenoic acid 11-46 renin Rattus norvegicus 178-183 3298043-6 1987 Similarly, 15-hydroperoxyeicosatetraenoic acid and its hydroxy derivative, 15-hydroxyeicosatetraenoic acid, at somewhat higher molar concentrations (10(-6) M) also reduced basal renin. Eicosatetraenoic acid, 15-hydroxy- 75-106 renin Rattus norvegicus 178-183 3298043-7 1987 These studies confirm prostacyclin as a potential renin secretagogue; however, its action in vitro is transient, probably because of its rapid degradation. Epoprostenol 22-34 renin Rattus norvegicus 50-55 3298043-8 1987 Our studies provide new evidence that products of the 12-lipoxygenase and 15-lipoxygenase pathways, reported to be present in renal vascular tissue, are potent inhibitors of renin secretion and much more active on a molar basis on renin secretion than is prostacyclin. Epoprostenol 255-267 renin Rattus norvegicus 174-179 3477616-1 1987 The influence of central and peripheral injections of dexamethasone and 17 beta-oestradiol on plasma, brain and aortic renin substrate was studied in the rat. Estradiol 72-90 renin Rattus norvegicus 119-124 3477616-2 1987 Whereas intraperitoneal or intravenous injection of these steroids raised renin substrate in plasma, brain and the aorta, intraventricular injection raised it only in the brain and aorta. Steroids 58-66 renin Rattus norvegicus 74-79 3477616-4 1987 Dissociation of the plasma and tissue renin-substrate levels in response to central administration of steroids indicates local synthesis of this protein, possibly under central control. Steroids 102-110 renin Rattus norvegicus 38-43 3477616-1 1987 The influence of central and peripheral injections of dexamethasone and 17 beta-oestradiol on plasma, brain and aortic renin substrate was studied in the rat. Dexamethasone 54-67 renin Rattus norvegicus 119-124 3307341-0 1987 Cyclosporin A-induced nephrotoxicity in the rat: relationship to increased plasma renin activity. Cyclosporine 0-13 renin Rattus norvegicus 82-87 3307341-3 1987 CsA-induced nephrotoxicity, characterized by reduced glomerular filtration rate (GFR) and urinary sodium flow, enzymuria and proximal tubular cell damage was accompanied by elevated plasma renin activity (PRA). Cyclosporine 0-3 renin Rattus norvegicus 189-194 3307341-12 1987 CsA nephrotoxicity in the rat is clearly associated with activation of the renin-angiotensin-aldosterone system. Cyclosporine 0-3 renin Rattus norvegicus 75-80 3294593-1 1987 Previous studies have indicated that administration of the serotonin releaser p-chloroamphetamine HCl produces a dose-dependent increase in renin secretion through a blood-borne renin-releasing factor. p-chloroamphetamine hcl 78-101 renin Rattus norvegicus 140-145 3315334-11 1987 Replacement with AIII did not correct the hypotension but completely reversed the renal and renin responses to enalaprilat and restored GT balance without affecting FF. Enalaprilat 111-122 renin Rattus norvegicus 92-97 3298044-7 1987 Thus, cyclosporin A-induced hyperreninemic hypoaldosteronism in the rat depends on opposing renal and adrenal effects, with a direct or feedback stimulation of renin secretion and a specific blockade of ANG II-mediated aldosterone production. Cyclosporine 6-19 renin Rattus norvegicus 33-38 3298045-4 1987 Sodium depletion resulted in increased renin expression in the kidney, heart, and adrenal, but not in the submandibular gland and testis. Sodium 0-6 renin Rattus norvegicus 39-44 3036414-11 1987 Plasma renin activity (PRA) increased from 30 +/- 3 to 59 +/- 7 ng of angiotensin (ANG) I h-1 ml-1 with verapamil alone, a significantly larger increment than the increase of PRA from 27 +/- 5 to 39 +/- 9 ng of ANG I h-1 ml-1 in GHR subjected to comparable blood pressure reduction by mechanical aortic constriction. Verapamil 104-113 renin Rattus norvegicus 7-12 3294593-1 1987 Previous studies have indicated that administration of the serotonin releaser p-chloroamphetamine HCl produces a dose-dependent increase in renin secretion through a blood-borne renin-releasing factor. p-chloroamphetamine hcl 78-101 renin Rattus norvegicus 178-183 3294593-3 1987 Plasma from p-chloroamphetamine-treated, nephrectomized rats was used to obtain the renin-releasing factor, which was fractionated by ultrafiltration into fractions of molecular weight ranges of 1000 to 5000, 5000 to 10,000, and 10,000 to 20,000. p-Chloroamphetamine 12-31 renin Rattus norvegicus 84-89 3294593-5 1987 Since previous studies have shown that lesions in the hypothalamus prevent the effect of p-chloroamphetamine on renin secretion, we tested whether a hypothalamic extract can release renin from kidney slices. p-Chloroamphetamine 89-108 renin Rattus norvegicus 112-117 3298044-3 1987 Two weeks of intragastric administration of cyclosporin A (5 mg/kg/day or or 20 mg/kg/day) resulted in large increases in plasma renin concentration (23 +/- 5, 70 +/- 12, and 79 +/- 11 ng/ml/hr in control rats and rats receiving 5 mg and 20 mg of cyclosporin A, respectively), with no parallel increments in plasma aldosterone. Cyclosporine 44-57 renin Rattus norvegicus 129-134 3596002-6 1987 Treatment of these N-acetylneuraminic acid (NeuNAc)-free forms with renin leads to a shift of these double bands to a more acid pH, indicating heterogeneity within the protein structure. N-Acetylneuraminic Acid 19-42 renin Rattus norvegicus 68-73 2439680-4 1987 Bay K 8644 caused a leftward shift of the dose-response curve of the potassium-induced decrease in renin release. Potassium 69-78 renin Rattus norvegicus 99-104 2439680-6 1987 The combination of the maximum effective doses of calcium channel agonists and norepinephrine exerted an apparent additive effect on the release of renin. Norepinephrine 79-93 renin Rattus norvegicus 148-153 2439680-8 1987 Nifedipine and verapamil elicited a blocking action on the inhibition of renin release by Bay K 8644 or CGP 28392, in a concentration-dependent manner. Nifedipine 0-10 renin Rattus norvegicus 73-78 2439680-8 1987 Nifedipine and verapamil elicited a blocking action on the inhibition of renin release by Bay K 8644 or CGP 28392, in a concentration-dependent manner. Verapamil 15-24 renin Rattus norvegicus 73-78 2439680-8 1987 Nifedipine and verapamil elicited a blocking action on the inhibition of renin release by Bay K 8644 or CGP 28392, in a concentration-dependent manner. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 90-100 renin Rattus norvegicus 73-78 2439680-9 1987 Calmodulin antagonists, such as trifluoperazine and calmidazolium suppressed significantly the decreasing effect of Bay K 8644 or CGP 28392 on renin release from the slices. Trifluoperazine 32-47 renin Rattus norvegicus 143-148 2439680-9 1987 Calmodulin antagonists, such as trifluoperazine and calmidazolium suppressed significantly the decreasing effect of Bay K 8644 or CGP 28392 on renin release from the slices. calmidazolium 52-65 renin Rattus norvegicus 143-148 3309510-0 1987 Angiotensin-converting enzyme inhibition with quinapril (CI-906) and captopril in spontaneously hypertensive rats with suppressed renin-angiotensin system. Captopril 69-78 renin Rattus norvegicus 130-135 3309510-2 1987 Renin was suppressed either by removal of 2/3 of the renal mass, deoxycorticosterone (DOC) treatment, or 1% of NaCl in drinking water. Desoxycorticosterone 65-84 renin Rattus norvegicus 0-5 3309510-2 1987 Renin was suppressed either by removal of 2/3 of the renal mass, deoxycorticosterone (DOC) treatment, or 1% of NaCl in drinking water. Desoxycorticosterone 86-89 renin Rattus norvegicus 0-5 3309510-2 1987 Renin was suppressed either by removal of 2/3 of the renal mass, deoxycorticosterone (DOC) treatment, or 1% of NaCl in drinking water. Sodium Chloride 111-115 renin Rattus norvegicus 0-5 3596002-6 1987 Treatment of these N-acetylneuraminic acid (NeuNAc)-free forms with renin leads to a shift of these double bands to a more acid pH, indicating heterogeneity within the protein structure. N-Acetylneuraminic Acid 44-50 renin Rattus norvegicus 68-73 2953257-7 1987 Inhibition of the renin-angiotensin system with captopril had no effect on the diuretic or natriuretic responses to atrial natriuretic peptide in conscious control or cirrhotic rats. Captopril 48-57 renin Rattus norvegicus 18-23 3302931-0 1987 Effects of amines, monensin and nigericin on the renin release from isolated superfused rat glomeruli. Nigericin 32-41 renin Rattus norvegicus 49-54 3555116-8 1987 Superfusion with calcium-free media and EDTA increased basal renin release 2.5-fold, and bradykinin stimulated a twofold increase in renin release. Calcium 17-24 renin Rattus norvegicus 61-66 2953525-6 1987 Intravenous ANP injection (2.5 nmol/kg) inhibited basal renin secretion in hydrated rats and also inhibited renin secretion which had been stimulated by prior dehydration. Atrial Natriuretic Factor 12-15 renin Rattus norvegicus 56-61 3555116-8 1987 Superfusion with calcium-free media and EDTA increased basal renin release 2.5-fold, and bradykinin stimulated a twofold increase in renin release. Edetic Acid 40-44 renin Rattus norvegicus 61-66 3555117-0 1987 Renin secretory effects of N6-cyclohexyladenosine: effects of dietary sodium. N(6)-cyclohexyladenosine 27-49 renin Rattus norvegicus 0-5 3555117-0 1987 Renin secretory effects of N6-cyclohexyladenosine: effects of dietary sodium. Sodium 70-76 renin Rattus norvegicus 0-5 3555117-1 1987 Previous observations by others have shown that Na deprivation augments and Na loading attenuates the inhibitory effect of exogenous adenosine on renin secretion in vivo. Adenosine 133-142 renin Rattus norvegicus 146-151 3555117-5 1987 N6-cyclohexyladenosine (CHA), an adenosine analogue that selectively activates the A1 subclass of adenosine receptors in the nanomolar to micromolar concentration range inhibited renin secretion over the same range of concentrations (nM-microM) and to approximately the same maximal extent (to 50% of the mean basal secretory rate) in cortical slices taken from Na-loaded, control, and Na-deprived rats. N(6)-cyclohexyladenosine 0-22 renin Rattus norvegicus 179-184 3555117-5 1987 N6-cyclohexyladenosine (CHA), an adenosine analogue that selectively activates the A1 subclass of adenosine receptors in the nanomolar to micromolar concentration range inhibited renin secretion over the same range of concentrations (nM-microM) and to approximately the same maximal extent (to 50% of the mean basal secretory rate) in cortical slices taken from Na-loaded, control, and Na-deprived rats. Adenosine 13-22 renin Rattus norvegicus 179-184 2953525-6 1987 Intravenous ANP injection (2.5 nmol/kg) inhibited basal renin secretion in hydrated rats and also inhibited renin secretion which had been stimulated by prior dehydration. Atrial Natriuretic Factor 12-15 renin Rattus norvegicus 108-113 3032710-1 1987 Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Enalapril 113-122 renin Rattus norvegicus 0-5 3550349-0 1987 Renin release in anesthetized rats is enhanced by the calmodulin antagonist W-7. W 7 76-79 renin Rattus norvegicus 0-5 3550349-1 1987 In foregoing work, we found that the release of renin from rat kidney cortical slices was stimulated by the calmodulin antagonist W-7. W 7 130-133 renin Rattus norvegicus 48-53 3550349-5 1987 Infusion of W-7 at 100 micrograms/kg/min resulted in a marked stimulation of renin release, but there was no significant alteration in the release when the same dose of W-5 was infused. W 7 12-15 renin Rattus norvegicus 77-82 3030698-8 1987 Captopril administration in sodium-depleted rats increased plasma concentrations of renin, des-angiotensin I-angiotensinogen, and angiotensin I and decreased plasma angiotensinogen concentration measured by both methods. Captopril 0-9 renin Rattus norvegicus 84-89 3030698-8 1987 Captopril administration in sodium-depleted rats increased plasma concentrations of renin, des-angiotensin I-angiotensinogen, and angiotensin I and decreased plasma angiotensinogen concentration measured by both methods. Sodium 28-34 renin Rattus norvegicus 84-89 3030698-10 1987 The angiotensinogen liver content and in vitro angiotensinogen release were decreased in sodium-depleted rats treated with a converting enzyme inhibitor, and these parameters were negatively correlated to in vivo plasma levels of renin, angiotensin I, and des-angiotensin I-angiotensinogen. Sodium 89-95 renin Rattus norvegicus 230-235 2821302-0 1987 Effect of converting enzyme inhibitor "enalapril" on plasma renin substrate of the spontaneously hypertensive rat. Enalapril 39-48 renin Rattus norvegicus 60-65 3037621-7 1987 Both the administration of indomethacin and of propranolol had a suppressing effect on renin release during atriopeptin III infusion. Indomethacin 27-39 renin Rattus norvegicus 87-92 3037621-7 1987 Both the administration of indomethacin and of propranolol had a suppressing effect on renin release during atriopeptin III infusion. Propranolol 47-58 renin Rattus norvegicus 87-92 3037621-9 1987 They also provide evidence that during infusion of such peptides, both prostaglandins and beta-adrenergic mechanisms are still involved in the regulation of renin secretion. Prostaglandins 71-85 renin Rattus norvegicus 157-162 2951326-8 1987 A bolus injection of the angiotensin II converting enzyme inhibitor teprotide (SQ 20881) resulted in a decrease in mean arterial pressure (p less than 0.05) that was comparable in all groups, and serum renin concentration was not elevated in the vasopressin analogue-treated rat. Teprotide 68-77 renin Rattus norvegicus 202-207 3032710-1 1987 Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Enalapril 124-130 renin Rattus norvegicus 0-5 3032710-1 1987 Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Salts 153-157 renin Rattus norvegicus 0-5 3032710-1 1987 Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Furosemide 168-178 renin Rattus norvegicus 0-5 3032710-1 1987 Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). fur 190-193 renin Rattus norvegicus 0-5 3297074-2 1987 The changes in plasma renin activity (PRA) after treatment with nisoldipine and these reference drugs were also studied. Nisoldipine 64-75 renin Rattus norvegicus 22-27 3297074-11 1987 As did nifedipine and nicardipine, nisoldipine caused an increase of the plasma renin activity in NR and SHR, though its potency was weaker than those of nifedipine and nicardipine. Nicardipine 22-33 renin Rattus norvegicus 80-85 3297074-11 1987 As did nifedipine and nicardipine, nisoldipine caused an increase of the plasma renin activity in NR and SHR, though its potency was weaker than those of nifedipine and nicardipine. Nisoldipine 35-46 renin Rattus norvegicus 80-85 3555376-1 1987 We have investigated the relationship between the acute blood pressure lowering effect of captopril and renin status. Captopril 90-99 renin Rattus norvegicus 104-109 3311501-0 1987 The effect of DOCA and 9 alpha-fludrocortisone on renal renin content and production. Desoxycorticosterone Acetate 14-18 renin Rattus norvegicus 56-61 3311501-0 1987 The effect of DOCA and 9 alpha-fludrocortisone on renal renin content and production. alpha-fludrocortisone 25-46 renin Rattus norvegicus 56-61 3311501-8 1987 Renal renin fell to a lower level with DOCA than with 9 alpha-fludrocortisone. Desoxycorticosterone Acetate 39-43 renin Rattus norvegicus 6-11 3311501-8 1987 Renal renin fell to a lower level with DOCA than with 9 alpha-fludrocortisone. alpha-fludrocortisone 56-77 renin Rattus norvegicus 6-11 3311501-10 1987 When DOCA and 9 alpha-fludrocortisone were stopped plasma renin levels rose rapidly and the renal renin levels increased. Desoxycorticosterone Acetate 5-9 renin Rattus norvegicus 58-63 3311501-10 1987 When DOCA and 9 alpha-fludrocortisone were stopped plasma renin levels rose rapidly and the renal renin levels increased. Desoxycorticosterone Acetate 5-9 renin Rattus norvegicus 98-103 3311501-10 1987 When DOCA and 9 alpha-fludrocortisone were stopped plasma renin levels rose rapidly and the renal renin levels increased. alpha-fludrocortisone 16-37 renin Rattus norvegicus 58-63 3311501-10 1987 When DOCA and 9 alpha-fludrocortisone were stopped plasma renin levels rose rapidly and the renal renin levels increased. alpha-fludrocortisone 16-37 renin Rattus norvegicus 98-103 3028172-1 1987 Exogenous adenosine affects renal hemodynamics, renal tubular transport processes, and the secretion of renin. Adenosine 10-19 renin Rattus norvegicus 104-109 2437402-4 1987 Atenolol (-48%), betaxolol (-63%), and propranolol (-29%) significantly suppressed plasma renin activity (PRA), and minoxidil elevated PRA by 150-315%. Atenolol 0-8 renin Rattus norvegicus 90-95 2437402-4 1987 Atenolol (-48%), betaxolol (-63%), and propranolol (-29%) significantly suppressed plasma renin activity (PRA), and minoxidil elevated PRA by 150-315%. Betaxolol 17-26 renin Rattus norvegicus 90-95 2437402-4 1987 Atenolol (-48%), betaxolol (-63%), and propranolol (-29%) significantly suppressed plasma renin activity (PRA), and minoxidil elevated PRA by 150-315%. Propranolol 39-50 renin Rattus norvegicus 90-95 3546690-0 1987 alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model. 2-methylproline 0-19 renin Rattus norvegicus 31-36 3546690-0 1987 alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model. 2-methylproline 0-19 renin Rattus norvegicus 119-124 3027486-1 1987 Adenosine analogs selective for the A1 subclass of adenosine receptors, such as N6-cyclohexyladenosine (CHA), inhibit renin secretion in in vitro preparations. Adenosine 0-9 renin Rattus norvegicus 118-123 3027486-1 1987 Adenosine analogs selective for the A1 subclass of adenosine receptors, such as N6-cyclohexyladenosine (CHA), inhibit renin secretion in in vitro preparations. N(6)-cyclohexyladenosine 80-102 renin Rattus norvegicus 118-123 3027486-1 1987 Adenosine analogs selective for the A1 subclass of adenosine receptors, such as N6-cyclohexyladenosine (CHA), inhibit renin secretion in in vitro preparations. N(6)-cyclohexyladenosine 104-107 renin Rattus norvegicus 118-123 3555376-3 1987 The blood pressure lowering effect of captopril correlated very closely with plasma or aortic renin across a very wide range of renin levels. Captopril 38-47 renin Rattus norvegicus 94-99 3555376-3 1987 The blood pressure lowering effect of captopril correlated very closely with plasma or aortic renin across a very wide range of renin levels. Captopril 38-47 renin Rattus norvegicus 128-133 3545200-1 1987 An increase in plasma prorenin during pregnancy suggests that prorenin might be synthesized in the ovary and the secretion of renin or prorenin may be stimulated by an ovarian steroid-mediated process. Steroids 176-183 renin Rattus norvegicus 25-30 3296006-2 1987 PGI2 may mediate, in part, the early increment in plasma renin activity (PRA) after furosemide. Epoprostenol 0-4 renin Rattus norvegicus 57-62 3296006-2 1987 PGI2 may mediate, in part, the early increment in plasma renin activity (PRA) after furosemide. Furosemide 84-94 renin Rattus norvegicus 57-62 3296006-3 1987 We hypothesized that thromboxane synthetase inhibition should direct prostaglandin endoperoxide metabolism toward PGI2, thereby enhancing the effects of furosemide on renin release. Prostaglandin Endoperoxides 69-95 renin Rattus norvegicus 167-172 3296006-3 1987 We hypothesized that thromboxane synthetase inhibition should direct prostaglandin endoperoxide metabolism toward PGI2, thereby enhancing the effects of furosemide on renin release. Furosemide 153-163 renin Rattus norvegicus 167-172 3324704-0 1987 Potassium supplementation lowers blood pressure in spontaneously hypertensive rats--relationships with urinary prostaglandins and renin. Potassium 0-9 renin Rattus norvegicus 130-135 3326401-8 1987 In DI rats was found a paradoxical antidiuretic effect of furanthril after either an acute or chronic treatment, which was attributed to the per se stimulated renin-angiotensin system and suppressed PG-synthesis typical for these rats. Furosemide 58-68 renin Rattus norvegicus 159-164 2449053-6 1987 In anaesthetised rats, aprotinin potentiated the increase in plasma renin produced by captopril. Captopril 86-95 renin Rattus norvegicus 68-73 3324704-3 1987 Plasma renin activity measured at the end of the study was significantly reduced in potassium supplemented animals compared to controls. Potassium 84-93 renin Rattus norvegicus 7-12 3544871-1 1987 The aim of the present study was to determine the extent to which vasopressin or the renin-angiotensin system contributed to the recovery of blood pressure following acute hypotension induced by treatment with pentolinium and captopril, or pentolinium and the vasopressin antagonist d(CH2)5DAVP, respectively, in conscious, free-moving rats treated 21 days previously with saline or streptozotocin (STZ) (60 mg/kg ip). Pentolinium Tartrate 210-221 renin Rattus norvegicus 85-90 3544871-4 1987 The vasopressin-mediated recovery in blood pressure seen following administration of pentolinium, in the presence of captopril, and the renin-angiotensin-mediated recovery seen following administration of pentolinium, in the presence of d(CH2)5DAVP, were both found to be significantly (P less than 0.05) attenuated in the STZ-treated animals. Pentolinium Tartrate 205-216 renin Rattus norvegicus 136-141 2437873-0 1987 BAY K 8644, a calcium channel agonist, inhibits renin secretion in vitro. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 0-10 renin Rattus norvegicus 48-53 3544871-4 1987 The vasopressin-mediated recovery in blood pressure seen following administration of pentolinium, in the presence of captopril, and the renin-angiotensin-mediated recovery seen following administration of pentolinium, in the presence of d(CH2)5DAVP, were both found to be significantly (P less than 0.05) attenuated in the STZ-treated animals. Streptozocin 323-326 renin Rattus norvegicus 136-141 2437873-1 1987 These experiments were designed to characterize the renin secretory effects of BAY K 8644, a dihydropyridine derivative which acts as a Ca channel agonist. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 79-89 renin Rattus norvegicus 52-57 2437873-3 1987 BAY K 8644 produced a concentration-dependent inhibition of basal renin secretion. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 0-10 renin Rattus norvegicus 66-71 2887315-12 1987 The plasma renin activity (in intact rats) was reduced by quinpirole, but elevated by fenoldopam. Quinpirole 58-68 renin Rattus norvegicus 11-16 3105853-0 1987 Effect of cyclooxygenase and thromboxane synthetase inhibition on furosemide-stimulated plasma renin activity. Furosemide 66-76 renin Rattus norvegicus 95-100 3105853-1 1987 We studied the effects of a specific thromboxane (TX) synthetase inhibitor (U-63,557A) and a cyclooxygenase inhibitor on furosemide-induced renin release. Furosemide 121-131 renin Rattus norvegicus 140-145 3105853-5 1987 Plasma renin activity was measured in blood samples collected 0, 10, 20, and 40 min after the injection of furosemide. Furosemide 107-117 renin Rattus norvegicus 7-12 3105853-7 1987 The results demonstrated that plasma renin activity rose with time following furosemide in the various groups of rats; indomethacin suppressed the furosemide-induced increments in plasma renin activity, while U-63,557A at doses of 4-8 mg X kg-1 augmented it. Furosemide 77-87 renin Rattus norvegicus 37-42 3105853-7 1987 The results demonstrated that plasma renin activity rose with time following furosemide in the various groups of rats; indomethacin suppressed the furosemide-induced increments in plasma renin activity, while U-63,557A at doses of 4-8 mg X kg-1 augmented it. Indomethacin 119-131 renin Rattus norvegicus 37-42 3105853-7 1987 The results demonstrated that plasma renin activity rose with time following furosemide in the various groups of rats; indomethacin suppressed the furosemide-induced increments in plasma renin activity, while U-63,557A at doses of 4-8 mg X kg-1 augmented it. Indomethacin 119-131 renin Rattus norvegicus 187-192 3105853-7 1987 The results demonstrated that plasma renin activity rose with time following furosemide in the various groups of rats; indomethacin suppressed the furosemide-induced increments in plasma renin activity, while U-63,557A at doses of 4-8 mg X kg-1 augmented it. Furosemide 147-157 renin Rattus norvegicus 37-42 3105853-7 1987 The results demonstrated that plasma renin activity rose with time following furosemide in the various groups of rats; indomethacin suppressed the furosemide-induced increments in plasma renin activity, while U-63,557A at doses of 4-8 mg X kg-1 augmented it. Furosemide 147-157 renin Rattus norvegicus 187-192 3105853-10 1987 Thus, these experiments suggest that thromboxane synthetase inhibition, within a narrow dosage range, potentiates furosemide-induced renin release while cyclooxygenase inhibition suppresses it. Furosemide 114-124 renin Rattus norvegicus 133-138 2955963-2 1987 A single oral administration of captopril decreased the plasma ANP level and increased the plasma renin activity (PRA). Captopril 32-41 renin Rattus norvegicus 98-103 2887315-12 1987 The plasma renin activity (in intact rats) was reduced by quinpirole, but elevated by fenoldopam. Fenoldopam 86-96 renin Rattus norvegicus 11-16 3304732-5 1987 Plasma renin concentration tended to decrease after melatonin treatment. Melatonin 52-61 renin Rattus norvegicus 7-12 3024863-5 1987 Similar results were obtained in normotensive rats treated with hydrochlorothiazide; the increase in coronary flow after captopril correlated significantly with the control plasma renin activity. Hydrochlorothiazide 64-83 renin Rattus norvegicus 180-185 3024863-5 1987 Similar results were obtained in normotensive rats treated with hydrochlorothiazide; the increase in coronary flow after captopril correlated significantly with the control plasma renin activity. Captopril 121-130 renin Rattus norvegicus 180-185 3038398-7 1987 The marked reduction of the pressor responses and norepinephrine overflow to nerve stimulation by captopril in the SHR suggests that the renin-angiotensin system in the vascular beds in enhanced in this model of hypertension. Norepinephrine 50-64 renin Rattus norvegicus 137-142 3038398-7 1987 The marked reduction of the pressor responses and norepinephrine overflow to nerve stimulation by captopril in the SHR suggests that the renin-angiotensin system in the vascular beds in enhanced in this model of hypertension. Captopril 98-107 renin Rattus norvegicus 137-142 3028766-5 1987 Mean arterial pressure decreased significantly from 117 +/- 4.3 to 103 +/- 6.7 mmHg (p less than 0.05) in the O2 exposed group despite a threefold increase in plasma renin activity. Oxygen 110-112 renin Rattus norvegicus 166-171 2948755-4 1987 During sodium depletion, the rise in plasma renin activity which determines an increment in the circulating concentration of angiotensin II was accompanied by a rise in aldosterone secretion as expected. Sodium 7-13 renin Rattus norvegicus 44-49 3109872-2 1987 Prostaglandins (PG) E2 and I2 have a number of effects on renal function, such as causing vasodilatation, increasing the glomerular filtration rate, sodium chloride excretion, water excretion, and stimulating renin secretion. Dinoprostone 0-22 renin Rattus norvegicus 209-214 2948755-7 1987 Since the increase in plasma aldosterone levels in sodium-depleted rats is mainly dependent on the activation of the renin-angiotensin system, we conclude that ANP may modulate the effect of endogenous as well as exogenous angiotensin II on plasma aldosterone secretion. Sodium 51-57 renin Rattus norvegicus 117-122 3327681-0 1987 Baroreflex control of renin release in spontaneously hypertensive rats after administration of felodipine. Felodipine 95-105 renin Rattus norvegicus 22-27 3327681-4 1987 The initial reflexogenic elevation in plasma renin activity and heart rate caused by felodipine-induced blood pressure reduction were successively normalised with time. Felodipine 85-95 renin Rattus norvegicus 45-50 3327682-9 1987 Therefore, the reflexogenic increase in heart rate and plasma renin activity subsided within 3 to 5 hours of continuous felodipine administration in SHR. Felodipine 120-130 renin Rattus norvegicus 62-67 3330576-0 1987 Role of endogenous adenosine as a modulator of the renin response to salt restriction. Adenosine 19-28 renin Rattus norvegicus 51-56 2892767-4 1987 Biochemically, the hypotensive effects of quinpirole were accompanied by a decrease in the plasma level of norepinephrine and plasma renin activity. Quinpirole 42-52 renin Rattus norvegicus 133-138 2454368-7 1987 A tendency toward a decrease in plasma renin activity was observed after oral carvedilol in SHR. Carvedilol 78-88 renin Rattus norvegicus 39-44 2455110-0 1987 Baroreflex control of heart rate and renin release in SHR following administration of felodipine, an antihypertensive Ca2+ antagonist. Felodipine 86-96 renin Rattus norvegicus 37-42 3326976-0 1987 Blood pressure and plasma renin activity after magnesium supplementation in the spontaneously hypertensive rat: a study during developing and established hypertension. Magnesium 47-56 renin Rattus norvegicus 26-31 3326976-1 1987 The effects of a dietary magnesium supplementation have been studied both on systolic blood pressure and plasma renin activity in the spontaneously hypertensive rat (SHR). Magnesium 25-34 renin Rattus norvegicus 112-117 3326976-4 1987 Plasma renin activity was similar after the two different diets in young SHR while it was greater in mature SHR receiving a high magnesium diet than in mature SHR receiving a normal diet. Magnesium 129-138 renin Rattus norvegicus 7-12 2441191-2 1987 In spontaneously hypertensive rats (SHR), 60-week treatment with nitrendipine resulted in normotensive blood pressure values without increasing body weight, an indicator of salt-water retention, or increasing plasma renin activity and plasma aldosterone concentration compared with the untreated rats. Nitrendipine 65-77 renin Rattus norvegicus 216-221 3330576-0 1987 Role of endogenous adenosine as a modulator of the renin response to salt restriction. Salts 69-73 renin Rattus norvegicus 51-56 3330576-1 1987 Numerous studies indicate that exogenous adenosine can inhibit renin release. Adenosine 41-50 renin Rattus norvegicus 63-68 3330576-2 1987 However, the hypothesis that endogenous adenosine functions to restrain the renin response to physiological and/or pharmacological stimuli remains untested. Adenosine 40-49 renin Rattus norvegicus 76-81 3330576-3 1987 To address this hypothesis, we examined the effects of a novel adenosine receptor antagonist, 1,3-dipropyl-8-para-sulfophenylxanthine (DPSPX), on renin release in rats on a normal versus a low salt diet. 1,3-dipropyl-8-para-sulfophenylxanthine 94-133 renin Rattus norvegicus 146-151 3330576-3 1987 To address this hypothesis, we examined the effects of a novel adenosine receptor antagonist, 1,3-dipropyl-8-para-sulfophenylxanthine (DPSPX), on renin release in rats on a normal versus a low salt diet. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 135-140 renin Rattus norvegicus 146-151 3330576-7 1987 These data support the hypothesis that endogenous adenosine functions to restrain the renin response to salt depletion. Adenosine 50-59 renin Rattus norvegicus 86-91 3330576-7 1987 These data support the hypothesis that endogenous adenosine functions to restrain the renin response to salt depletion. Salts 104-108 renin Rattus norvegicus 86-91 3024511-3 1986 A twofold elevation in dipsogenic responsiveness was observed in the fasted rats, and this enhanced response was correlated with a dose-dependent increase in plasma renin activity when compared with the control rats after administration of isoproterenol. Isoproterenol 240-253 renin Rattus norvegicus 165-170 3024511-8 1986 Therefore stimulation of these increased renal receptors by isoproterenol could result in an enhanced activation of the renin-angiotensin system and thus be a factor responsible for the increased dipsogenic response induced by isoproterenol observed in the fasted rats. Isoproterenol 60-73 renin Rattus norvegicus 120-125 3024511-8 1986 Therefore stimulation of these increased renal receptors by isoproterenol could result in an enhanced activation of the renin-angiotensin system and thus be a factor responsible for the increased dipsogenic response induced by isoproterenol observed in the fasted rats. Isoproterenol 227-240 renin Rattus norvegicus 120-125 3539793-1 1986 A potent renin inhibitor, U-71038 (Boc-Pro-Phe-N-MeHis-Leu psi[CHOHCH2]Val-Ile-Amp), was tested for oral effectiveness. ditekiren 26-33 renin Rattus norvegicus 9-14 3789193-1 1986 We investigated whether the increased intake of water during dietary electrolyte depletion is related to activation of the renin-angiotensin system. Water 48-53 renin Rattus norvegicus 123-128 3539793-2 1986 Enzyme kinetic studies indicated that U-71038 was a competitive inhibitor of hog renin with an inhibitor constant (Ki) value of 12 nM. ditekiren 38-45 renin Rattus norvegicus 81-86 3539793-3 1986 Intravenous as well as oral administration of U-71038 to anesthetized, ganglion-blocked rats infused with hog renin elicited dose-related hypotensive responses. ditekiren 46-53 renin Rattus norvegicus 110-115 3539793-4 1986 Intravenous administration of U-71038 to conscious, sodium-depleted monkeys caused dose-related decreases of blood pressure and plasma renin activity without affecting heart rate. ditekiren 30-37 renin Rattus norvegicus 135-140 3539793-4 1986 Intravenous administration of U-71038 to conscious, sodium-depleted monkeys caused dose-related decreases of blood pressure and plasma renin activity without affecting heart rate. Sodium 52-58 renin Rattus norvegicus 135-140 3553474-1 1986 Plasma renin activity (PRA) is characteristically lower in the Dahl salt-sensitive (S) rat than in the salt-resistant (R) rat. dahl salt 63-72 renin Rattus norvegicus 7-12 3553474-1 1986 Plasma renin activity (PRA) is characteristically lower in the Dahl salt-sensitive (S) rat than in the salt-resistant (R) rat. Salts 68-72 renin Rattus norvegicus 7-12 3819389-18 1986 The brain renin-angiotensin system in the SHR may play an important role in this accelerated pressor response and may be responsible, at least to some extent, for the enhanced reaction to chronic oral salt loading. Salts 201-205 renin Rattus norvegicus 10-15 3553472-3 1986 However, calcium loading in renin-dependent 2K, 1C rats elevated blood pressure (P less than 0.05) but had no effect in sham-operated controls. Calcium 9-16 renin Rattus norvegicus 28-33 3539793-5 1986 Similarly, the oral administration of U-71038 at 50 mg/kg to conscious, sodium-depleted monkeys elicited a pronounced hypotension and decrease in plasma renin activity that persisted for 5 hours. ditekiren 38-45 renin Rattus norvegicus 153-158 3539793-5 1986 Similarly, the oral administration of U-71038 at 50 mg/kg to conscious, sodium-depleted monkeys elicited a pronounced hypotension and decrease in plasma renin activity that persisted for 5 hours. Sodium 72-78 renin Rattus norvegicus 153-158 3027437-12 1986 SA-446 and kallidinogenase significantly inhibited the decrease in plasma renin activity and the increase in urinary aldosterone excretion. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 renin Rattus norvegicus 74-79 3539795-0 1986 Suppression of adrenal renin in Dahl salt-sensitive rats. Salts 37-41 renin Rattus norvegicus 23-28 3539795-1 1986 We previously showed that adrenal renin is highest in the rat zona glomerulosa (ZG) and that low sodium or high potassium and nephrectomy increase adrenal ZG renin and aldosterone. Sodium 97-103 renin Rattus norvegicus 158-163 3539795-1 1986 We previously showed that adrenal renin is highest in the rat zona glomerulosa (ZG) and that low sodium or high potassium and nephrectomy increase adrenal ZG renin and aldosterone. Potassium 112-121 renin Rattus norvegicus 158-163 3539795-2 1986 Dahl salt-sensitive rats (S) have been shown to have lower plasma renin activity and plasma aldosterone and higher plasma 18-hydroxy-11-deoxycorticosterone than Dahl salt-resistant rats (R). dahl salt 0-9 renin Rattus norvegicus 66-71 3021625-8 1986 In conclusion, three factors influence the response of adrenal renin to nephrectomy: 1) the pituitary through the release of ACTH, 2) a direct stimulation by high plasma potassium levels, 3) the lack of angiotensin II feedback inhibition. Potassium 170-179 renin Rattus norvegicus 63-68 3533396-5 1986 Significant increments above baseline renin release were seen with the stimuli of adrenaline, noradrenaline and isoprenaline. Epinephrine 82-92 renin Rattus norvegicus 38-43 3533396-5 1986 Significant increments above baseline renin release were seen with the stimuli of adrenaline, noradrenaline and isoprenaline. Norepinephrine 94-107 renin Rattus norvegicus 38-43 3533396-5 1986 Significant increments above baseline renin release were seen with the stimuli of adrenaline, noradrenaline and isoprenaline. Isoproterenol 112-124 renin Rattus norvegicus 38-43 3533999-6 1986 These findings provide evidence for sodium regulation of renal renin and angiotensinogen mRNA expressions, which supports potential existence of an intrarenally regulated RAS and suggest that different factors regulate renal and hepatic angiotensinogen. Sodium 36-42 renin Rattus norvegicus 63-68 3021625-5 1986 Potassium also plays an important role, since prevention of hyperkalemia after nephrectomy by treatment with a cation exchange resin, sodium polystyrene sulfonate (Kayexalate), significantly reduced the adrenal renin response to nephrectomy. Potassium 0-9 renin Rattus norvegicus 211-216 3021625-5 1986 Potassium also plays an important role, since prevention of hyperkalemia after nephrectomy by treatment with a cation exchange resin, sodium polystyrene sulfonate (Kayexalate), significantly reduced the adrenal renin response to nephrectomy. polystyrene sulfonic acid 134-162 renin Rattus norvegicus 211-216 3021625-5 1986 Potassium also plays an important role, since prevention of hyperkalemia after nephrectomy by treatment with a cation exchange resin, sodium polystyrene sulfonate (Kayexalate), significantly reduced the adrenal renin response to nephrectomy. polystyrene sulfonic acid 164-174 renin Rattus norvegicus 211-216 3537461-1 1986 We have suggested that inhibition of renin release by sodium chloride is related to increased absorptive solute transport in the loop of Henle. Sodium Chloride 54-69 renin Rattus norvegicus 37-42 3550037-0 1986 Effects of labetalol on renin release from rat kidney cortical slices. Labetalol 11-20 renin Rattus norvegicus 24-29 3550037-1 1986 Effects of labetalol, a combined alpha- and beta-adrenoceptor blocking agent, on the changes in renin release in response to isoproterenol or norepinephrine were examined in comparison with those of propranolol and prazosin, using rat kidney cortical slices. Labetalol 11-20 renin Rattus norvegicus 96-101 3550037-1 1986 Effects of labetalol, a combined alpha- and beta-adrenoceptor blocking agent, on the changes in renin release in response to isoproterenol or norepinephrine were examined in comparison with those of propranolol and prazosin, using rat kidney cortical slices. Isoproterenol 125-138 renin Rattus norvegicus 96-101 3537461-2 1986 In the rat, we have shown that reduced chloride transport in the loop is associated with increased renin release. Chlorides 39-47 renin Rattus norvegicus 99-104 3550037-1 1986 Effects of labetalol, a combined alpha- and beta-adrenoceptor blocking agent, on the changes in renin release in response to isoproterenol or norepinephrine were examined in comparison with those of propranolol and prazosin, using rat kidney cortical slices. Norepinephrine 142-156 renin Rattus norvegicus 96-101 3537461-10 1986 These results demonstrate that an increase in loop chloride reabsorption is associated with a decrease in renin release. Chlorides 51-59 renin Rattus norvegicus 106-111 3550037-2 1986 Isoproterenol (10(-9) to 10(-5) M) produced a dose-related increasing effect on renin release from the slices, although the increased release was markedly attenuated by the higher dose (10(-4) M). Isoproterenol 0-13 renin Rattus norvegicus 80-85 3537461-11 1986 This observation is consistent with the hypothesis that renin release is inversely related to the magnitude of chloride transport in the thick ascending limb of the loop of Henle. Chlorides 111-119 renin Rattus norvegicus 56-61 3550037-5 1986 However, the agent exerted a concentration-dependent blocking action on the renin response to 10(-6) M isoproterenol. Isoproterenol 103-116 renin Rattus norvegicus 76-81 3540814-3 1986 The intracerebral administration of renin and angiotensin II produces an increase in latencies to thermoalgesic stimuli; this is reduced, as is immobilization stress, by naloxone and saralasin. Naloxone 170-178 renin Rattus norvegicus 36-60 3550037-7 1986 The decreased response of renin release to 10(-5) M norepinephrine was significantly inhibited by labetalol over 10(-6) M. Labetalol, at a concentration of 10(-5) M, abolished the decreased release by 10(-5) M norepinephrine. Norepinephrine 52-66 renin Rattus norvegicus 26-31 3550037-7 1986 The decreased response of renin release to 10(-5) M norepinephrine was significantly inhibited by labetalol over 10(-6) M. Labetalol, at a concentration of 10(-5) M, abolished the decreased release by 10(-5) M norepinephrine. Labetalol 98-107 renin Rattus norvegicus 26-31 3550037-7 1986 The decreased response of renin release to 10(-5) M norepinephrine was significantly inhibited by labetalol over 10(-6) M. Labetalol, at a concentration of 10(-5) M, abolished the decreased release by 10(-5) M norepinephrine. Labetalol 123-132 renin Rattus norvegicus 26-31 3550037-7 1986 The decreased response of renin release to 10(-5) M norepinephrine was significantly inhibited by labetalol over 10(-6) M. Labetalol, at a concentration of 10(-5) M, abolished the decreased release by 10(-5) M norepinephrine. Norepinephrine 210-224 renin Rattus norvegicus 26-31 3550037-8 1986 On the other hand, the decreasing effect of 10(-5) M norepinephrine was substantially reversed rather than abolished by prazosin over 10(-7) M. These results indicate that labetalol inhibited the response of renin in rat kidney cortical slices, by beta- and alpha 1-adrenoceptor antagonistic action, respectively. Norepinephrine 53-67 renin Rattus norvegicus 208-213 3550037-8 1986 On the other hand, the decreasing effect of 10(-5) M norepinephrine was substantially reversed rather than abolished by prazosin over 10(-7) M. These results indicate that labetalol inhibited the response of renin in rat kidney cortical slices, by beta- and alpha 1-adrenoceptor antagonistic action, respectively. Labetalol 172-181 renin Rattus norvegicus 208-213 3540814-3 1986 The intracerebral administration of renin and angiotensin II produces an increase in latencies to thermoalgesic stimuli; this is reduced, as is immobilization stress, by naloxone and saralasin. Saralasin 183-192 renin Rattus norvegicus 36-60 3760671-4 1986 At sacrifice, urine flow rate and fractional excretion of sodium were increased and plasma renin activity decreased in both SAL and ALB rats. sal 124-127 renin Rattus norvegicus 91-96 2878069-3 1986 Atenolol, betaxolol and propranolol significantly suppressed plasma renin activity (PRA), whereas oxprenolol, pindolol and sotalol did not alter PRA significantly. Atenolol 0-8 renin Rattus norvegicus 68-73 2878069-3 1986 Atenolol, betaxolol and propranolol significantly suppressed plasma renin activity (PRA), whereas oxprenolol, pindolol and sotalol did not alter PRA significantly. Betaxolol 10-19 renin Rattus norvegicus 68-73 2878069-3 1986 Atenolol, betaxolol and propranolol significantly suppressed plasma renin activity (PRA), whereas oxprenolol, pindolol and sotalol did not alter PRA significantly. Propranolol 24-35 renin Rattus norvegicus 68-73 3018407-2 1986 This issue was examined in a series of experiments performed in a system of rat renal cortical slices (dry weight 1.91 mg) in which the goal was to explore the effects of AP on renin release induced by cyclic AMP (cAMP)-coupled stimuli or by agents which are believed to decrease intracellular calcium (Cai). Cyclic AMP 202-212 renin Rattus norvegicus 177-182 3018765-0 1986 Role of volume and prostaglandin synthesis in the suppression of renin by saline in the rat. Prostaglandins 19-32 renin Rattus norvegicus 65-70 3018765-0 1986 Role of volume and prostaglandin synthesis in the suppression of renin by saline in the rat. Sodium Chloride 74-80 renin Rattus norvegicus 65-70 3018765-4 1986 Plasma renin activity (PRA) decreased in response to saline (12.3 +/- 1.0 to 6.7 +/- 0.7 ng AI/ml/hr; P less than 0.01) whereas PRA did not change with sodium bicarbonate (11.3 +/- 1.4 to 10.2 +/- 1.5) or albumin (9.9 +/- 0.7 to 8.2 +/- 1.0). Sodium Chloride 53-59 renin Rattus norvegicus 7-12 3018765-7 1986 In confirmation of earlier observations, inhibition of renin release by sodium chloride was related to chloride. Sodium Chloride 72-87 renin Rattus norvegicus 55-60 3018765-7 1986 In confirmation of earlier observations, inhibition of renin release by sodium chloride was related to chloride. Chlorides 79-87 renin Rattus norvegicus 55-60 3018765-8 1986 Finally, the results suggest that the renal tubular mechanism for inhibition of renin release by sodium chloride is not related to overall changes in renal PGE2 synthesis in the rat. Sodium Chloride 97-112 renin Rattus norvegicus 80-85 3018407-5 1986 The addition of AP (2.09 X 10(-8) M, a minimum inhibitory concentration derived from preliminary studies) significantly blunted these increases; in the case of the dibutyryl cAMP-stimulated renin release, the inhibition was partial as a significant 25% increase in renin occurred in the presence of AP. Cyclic AMP 174-178 renin Rattus norvegicus 190-195 3018407-6 1986 The addition of the calcium channel blocking agent diltiazem (10(-4) M) resulted in a significant increase in renin release (364 to 567 ng X mg-1, p less than .05) which was not blocked by the addition of AP. Diltiazem 51-60 renin Rattus norvegicus 110-115 3018407-7 1986 Similarly, TMB-8 (0.6 X 10(-4) M), another agent thought to lower Cai, also resulted in increased renin release (455 to 810 ng X mg-1), p less than .01) which was also unaffected by the addition of the AP. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 11-16 renin Rattus norvegicus 98-103 3531461-0 1986 Effect of short-term cyclosporine administration in rats on renin-angiotensin and thromboxane A2: possible relevance to the reduction in glomerular filtration rate. Cyclosporine 21-33 renin Rattus norvegicus 60-65 3531461-3 1986 With the present work we have examined the relationship between the reduction in GFR which follows a short-term administration of CyA in rats and the biochemical changes in renin-angiotensin system and renal arachidonic acid metabolism. Cyclosporine 130-133 renin Rattus norvegicus 173-178 3531461-4 1986 Our results show that CyA administration (25 mg/kg/day) for 45 days stimulates renin-angiotensin system with an increase in plasma renin activity. Cyclosporine 22-25 renin Rattus norvegicus 79-84 3531461-4 1986 Our results show that CyA administration (25 mg/kg/day) for 45 days stimulates renin-angiotensin system with an increase in plasma renin activity. Cyclosporine 22-25 renin Rattus norvegicus 131-136 3018407-2 1986 This issue was examined in a series of experiments performed in a system of rat renal cortical slices (dry weight 1.91 mg) in which the goal was to explore the effects of AP on renin release induced by cyclic AMP (cAMP)-coupled stimuli or by agents which are believed to decrease intracellular calcium (Cai). Cyclic AMP 214-218 renin Rattus norvegicus 177-182 3018407-4 1986 The cAMP stimuli utilized were isoproterenol (10(-5) M), forskolin (10(-5) M), and dibutyryl cAMP (3 X 10(-4) M); each of these agents produced a significant increase in renin release in the system (with isoproterenol a 59% increase, with forskolin 37%, and with dibutyryl cAMP 52%). Cyclic AMP 4-8 renin Rattus norvegicus 170-175 3018407-4 1986 The cAMP stimuli utilized were isoproterenol (10(-5) M), forskolin (10(-5) M), and dibutyryl cAMP (3 X 10(-4) M); each of these agents produced a significant increase in renin release in the system (with isoproterenol a 59% increase, with forskolin 37%, and with dibutyryl cAMP 52%). dibutyryl 83-92 renin Rattus norvegicus 170-175 2942044-4 1986 min-1 significantly decreased aldosterone secretion by 32% and plasma renin activity by 55% in rats that had been maintained on a normal-sodium diet. Sodium 137-143 renin Rattus norvegicus 70-75 3542105-0 1986 Stimulation and suppression of renin release from incubations of rat renal cortex by factors affecting calcium flux. Calcium 103-110 renin Rattus norvegicus 31-36 3542105-2 1986 AII inhibition of isoprenaline-stimulated renin secretion was only partially dependent on external Ca2+. Isoproterenol 18-30 renin Rattus norvegicus 42-47 3542105-3 1986 Ouabain and K+ depletion inhibited isoprenaline-stimulated renin release but only in the presence of external Ca2+. Isoproterenol 35-47 renin Rattus norvegicus 59-64 3542105-4 1986 Since, in Ca2+-free medium, isoprenaline stimulated renin release when the Na+/K+-ATPase was blocked, isoprenaline probably does not act through the Na+/K+-ATPase. Isoproterenol 28-40 renin Rattus norvegicus 52-57 3542105-5 1986 Lanthanum blocked the stimulation of renin release by isoprenaline. Lanthanum 0-9 renin Rattus norvegicus 37-42 3542105-5 1986 Lanthanum blocked the stimulation of renin release by isoprenaline. Isoproterenol 54-66 renin Rattus norvegicus 37-42 3542105-6 1986 Ethylenediamine tetra-acetic acid (EDTA) and ethyleneglycol-bis-(beta-amino-ethyl ether) N,N"-tetra-acetic acid (EGTA) increased renin secretion to a similar degree in Ca2+- and Mg2+-free buffer. Edetic Acid 35-39 renin Rattus norvegicus 129-134 3542105-6 1986 Ethylenediamine tetra-acetic acid (EDTA) and ethyleneglycol-bis-(beta-amino-ethyl ether) N,N"-tetra-acetic acid (EGTA) increased renin secretion to a similar degree in Ca2+- and Mg2+-free buffer. Egtazic Acid 113-117 renin Rattus norvegicus 129-134 3542105-6 1986 Ethylenediamine tetra-acetic acid (EDTA) and ethyleneglycol-bis-(beta-amino-ethyl ether) N,N"-tetra-acetic acid (EGTA) increased renin secretion to a similar degree in Ca2+- and Mg2+-free buffer. magnesium ion 178-182 renin Rattus norvegicus 129-134 3542105-8 1986 Verapamil reduced the fall in basal renin secretion in normal but not Ca2+-free buffer. Verapamil 0-9 renin Rattus norvegicus 36-41 3524263-5 1986 A 30-mosmol/kg reduction in medium sodium chloride concentration increased renin release from SAG 50% (P less than 0.01). Sodium Chloride 35-50 renin Rattus norvegicus 75-80 3524265-4 1986 Plasma renin activity (PRA) was higher in HP (10.0 +/- 2.5 vs. 3.5 +/- 0.5 ng ANG I . histidylproline 42-44 renin Rattus norvegicus 7-12 3524272-1 1986 The effects of long-term hypophysectomy on renin secretion and the renin and drinking responses to isoproterenol were investigated in male rats. Isoproterenol 99-112 renin Rattus norvegicus 67-72 3524272-5 1986 Isoproterenol produced a smaller increase in plasma renin activity in hypophysectomized rats than it did in controls, but with the one dose of isoproterenol that was tested, the increase in plasma renin concentration was comparable in the two groups. Isoproterenol 0-13 renin Rattus norvegicus 52-57 3542105-10 1986 Bay K 8644 inhibited renin secretion from cortex incubated in medium containing 15 mM K+ and this was dependent on extracellular Ca2+. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 0-10 renin Rattus norvegicus 21-26 3525406-7 1986 By sodium dodecyl sulfate gel electrophoresis, the stored renin had two different molecular weights, 38,000 and 36,000, and these molecular weights were not reduced by dithiothreitol or 2-mercaptoethanol, suggesting that these renins are single-chain types as opposed to the two-chain type found in male mouse submaxillary gland. Sodium Dodecyl Sulfate 3-25 renin Rattus norvegicus 58-63 3019053-5 1986 Corticosterone, 18-hydroxycorticosterone and deoxycorticosterone plasma concentrations were suppressed in both groups by dexamethasone treatment; plasma renin concentrations were lower in ARH rats than in controls. Dexamethasone 121-134 renin Rattus norvegicus 153-158 3524272-5 1986 Isoproterenol produced a smaller increase in plasma renin activity in hypophysectomized rats than it did in controls, but with the one dose of isoproterenol that was tested, the increase in plasma renin concentration was comparable in the two groups. Isoproterenol 143-156 renin Rattus norvegicus 197-202 2942044-5 1986 Similar reductions in aldosterone secretion and plasma renin activity were observed in hyperreninemic rats after chronic sodium restriction. Sodium 121-127 renin Rattus norvegicus 55-60 3539430-0 1986 Effect of acute administration of prazosin on blood pressure, heart rate and plasma renin level in the conscious normotensive rat. Prazosin 34-42 renin Rattus norvegicus 84-89 3539430-1 1986 This study investigated whether the specific alpha-antagonist, prazosin, stimulated basal plasma renin levels and heart rate. Prazosin 63-71 renin Rattus norvegicus 97-102 3539430-5 1986 Acute administration of prazosin (1 mg/kg, s.c.) produced a fall in mean arterial pressure accompanied by renin release and tachycardia. Prazosin 24-32 renin Rattus norvegicus 106-111 3539430-6 1986 A tenfold lower dose of prazosin did not alter blood pressure or heart rate but did stimulate renin release. Prazosin 24-32 renin Rattus norvegicus 94-99 3539430-9 1986 Prazosin-induced tachycardia and renin release were attenuated by propranolol. Propranolol 66-77 renin Rattus norvegicus 33-38 3539430-10 1986 It appears that prazosin produces renin release and tachycardia via stimulation of the beta-adrenergic adrenoceptor. Prazosin 16-24 renin Rattus norvegicus 34-39 3525199-0 1986 The different effects of exogenous and neuronally released norepinephrine on renin release in rat kidney cortical slices. Norepinephrine 59-73 renin Rattus norvegicus 77-82 3525199-1 1986 The effects of veratrine on renin release from rat kidney cortical slices were compared with those of norepinephrine (NE). Veratrine 15-24 renin Rattus norvegicus 28-33 3525199-2 1986 Veratrine (10-100 micrograms/ml) produced a concentration-dependent increase in renin release. Veratrine 0-9 renin Rattus norvegicus 80-85 3521182-2 1986 Treatment with a chloride-deficient diet led to a temporary decrease in the capsular adrenal conversions of corticosterone to 18-hydroxycorticosterone and aldosterone (manifest after 2 weeks but not longer apparent after 3 weeks), which was accompanied by a progressive rise in plasma renin activity and a moderate fall in plasma potassium. Chlorides 17-25 renin Rattus norvegicus 285-290 3099704-5 1986 Results presented here confirm that RRM-salt rats exhibit: volume expansion, strongly decreased plasma renin activity, increased endogenous "ouabain-like" factors and (IV) decreased Na+, K+-pump activity and increased Na+ content in erythrocytes. Salts 40-44 renin Rattus norvegicus 103-108 2428551-0 1986 Effects of arotinolol, an alpha- and beta-adrenoceptor antagonist, on renin release from rat kidney cortical slices. arotinolol 11-21 renin Rattus norvegicus 70-75 2428551-1 1986 The effects of arotinolol on changes in renin release in rat kidney cortical slices in response to isoproterenol (IP) or norepinephrine (NE), were studied in comparison with those of AC-623, a main metabolite of arotinolol, and other typical adrenoceptor antagonists. arotinolol 15-25 renin Rattus norvegicus 40-45 2428551-1 1986 The effects of arotinolol on changes in renin release in rat kidney cortical slices in response to isoproterenol (IP) or norepinephrine (NE), were studied in comparison with those of AC-623, a main metabolite of arotinolol, and other typical adrenoceptor antagonists. Isoproterenol 99-112 renin Rattus norvegicus 40-45 2428551-1 1986 The effects of arotinolol on changes in renin release in rat kidney cortical slices in response to isoproterenol (IP) or norepinephrine (NE), were studied in comparison with those of AC-623, a main metabolite of arotinolol, and other typical adrenoceptor antagonists. Isoproterenol 114-116 renin Rattus norvegicus 40-45 2428551-1 1986 The effects of arotinolol on changes in renin release in rat kidney cortical slices in response to isoproterenol (IP) or norepinephrine (NE), were studied in comparison with those of AC-623, a main metabolite of arotinolol, and other typical adrenoceptor antagonists. Norepinephrine 121-135 renin Rattus norvegicus 40-45 2428551-2 1986 Arotinolol, at concentrations of 10(-8) to 10(-4) mol/l, inhibited the increasing effect of 10(-6) mol/l IP on renin release, in a concentration-dependent manner. arotinolol 0-10 renin Rattus norvegicus 111-116 2428551-4 1986 The blocking effect of arotinolol on the 10(-5) mol/l NE-induced decrease in renin release was much less potent than seen with other alpha-adrenoceptor blocking agents such as prazosin, phenoxybenzamine and labetalol. arotinolol 23-33 renin Rattus norvegicus 77-82 2428551-5 1986 These data suggest that the potent blocking effects of arotinolol and its metabolite on the increased renin release in response to beta-adrenoceptor stimulation may contribute to the antihypertensive effect of this agent. arotinolol 55-65 renin Rattus norvegicus 102-107 2873229-1 1986 In rats maintained for 50 days on a low-sodium diet and with a compensatory hyperactivity of the renin-angiotensin system, the antinociceptive activity of morphine was significantly longer-lasting than in controls. Morphine 155-163 renin Rattus norvegicus 97-102 3025427-0 1986 Forskolin and calcium: interactions in the control of renin secretion and perfusate flow in the isolated rat kidney. Colforsin 0-9 renin Rattus norvegicus 54-59 3025427-0 1986 Forskolin and calcium: interactions in the control of renin secretion and perfusate flow in the isolated rat kidney. Calcium 14-21 renin Rattus norvegicus 54-59 3025427-2 1986 Forskolin stimulated renin secretion and caused vasodilation in a dose-dependent manner in medium containing 5 mM-Ca2+. Colforsin 0-9 renin Rattus norvegicus 21-26 3025427-4 1986 High K+ concentration reversed the forskolin-induced renin secretion and vasodilation. Colforsin 35-44 renin Rattus norvegicus 53-58 3025427-5 1986 Conversely, forskolin reversed the high K+-induced renin inhibition of renin secretion and vasoconstriction. Colforsin 12-21 renin Rattus norvegicus 51-56 3025427-5 1986 Conversely, forskolin reversed the high K+-induced renin inhibition of renin secretion and vasoconstriction. Colforsin 12-21 renin Rattus norvegicus 71-76 3025427-7 1986 High renal perfusion pressure also reversed the forskolin-induced renin secretion. Colforsin 48-57 renin Rattus norvegicus 66-71 3025427-10 1986 The calmidazolium-induced stimulation of renin secretion was Ca2+-dependent since the drug was ineffective in the absence of Ca2+. calmidazolium 4-17 renin Rattus norvegicus 41-46 3025427-12 1986 These results support the hypothesis that cyclic AMP stimulates renin secretion by a mechanism which involves a lowering of membrane permeability to Ca2+ in addition to lowering cytosolic Ca2+ concentration. Cyclic AMP 42-52 renin Rattus norvegicus 64-69 3517882-5 1986 The change in the proportions of the more acidic renin forms was greater with chronic stimulation than that after stimulation with verapamil. Verapamil 131-140 renin Rattus norvegicus 49-54 3518450-4 1986 In addition, the effect of nicotine on renin secretion was evaluated in vitro. Nicotine 27-35 renin Rattus norvegicus 39-44 3516662-0 1986 Renin in the rat pituitary coexists with angiotensin II and depends on testosterone. Testosterone 71-83 renin Rattus norvegicus 0-5 3516662-3 1986 This effect of castration on renin immunoreactivity was abolished by the simultaneous administration of testosterone. Testosterone 104-116 renin Rattus norvegicus 29-34 3014096-5 1986 Data indicated that the inhibition of renin release by ANP was related to the rise in cGMP and not to the fall of cAMP. Cyclic GMP 86-90 renin Rattus norvegicus 38-43 3014096-7 1986 We found, however, that the inhibitory effect of ANP on renin release could be attenuated by the calcium channel blocker verapamil. Verapamil 121-130 renin Rattus norvegicus 56-61 3014096-8 1986 Our results suggest that ANP inhibits renin release from juxtaglomerular cells by a mechanism that is mediated by cGMP; the mechanism is not linked to any alteration in intracellular calcium concentration but requires a normal level of calcium. Cyclic GMP 114-118 renin Rattus norvegicus 38-43 3012198-1 1986 Earlier experiments have shown that in sodium depleted hypertensive rats with bilaterally constricted renal arteries the arterial pressure normalized after blockade of the renin-angiotensin system; simultaneously acute renal failure occurred. Sodium 39-45 renin Rattus norvegicus 172-177 3521182-3 1986 Combined restriction of sodium, potassium and chloride elicited a decreased activity of the enzyme(s) involved in late steps in aldosterone biosynthesis, an elevation of plasma renin activity to excessively high levels and a substantial hypokalaemia. Potassium 32-41 renin Rattus norvegicus 177-182 3521182-3 1986 Combined restriction of sodium, potassium and chloride elicited a decreased activity of the enzyme(s) involved in late steps in aldosterone biosynthesis, an elevation of plasma renin activity to excessively high levels and a substantial hypokalaemia. Chlorides 46-54 renin Rattus norvegicus 177-182 3521182-4 1986 Chloride repletion of these rats by the addition of NH4Cl or CaCl2 to their drinking fluid stimulated aldosterone biosynthesis while lowering plasma renin activity and raising plasma potassium. Chlorides 0-8 renin Rattus norvegicus 149-154 3521182-4 1986 Chloride repletion of these rats by the addition of NH4Cl or CaCl2 to their drinking fluid stimulated aldosterone biosynthesis while lowering plasma renin activity and raising plasma potassium. Ammonium Chloride 52-57 renin Rattus norvegicus 149-154 3521182-4 1986 Chloride repletion of these rats by the addition of NH4Cl or CaCl2 to their drinking fluid stimulated aldosterone biosynthesis while lowering plasma renin activity and raising plasma potassium. Calcium Chloride 61-66 renin Rattus norvegicus 149-154 3518497-3 1986 Although plasma Na+ concentration, osmolality, and hematocrit of dehydrated rats had returned to control replete levels by 2-4 h after the return of water, the plasma renin and angiotensin II levels exhibited a further increase on rehydration and remained significantly above dehydration levels for 2-4 h after the return of water. Water 325-330 renin Rattus norvegicus 167-191 3010745-2 1986 Uremia was induced in rats by bilateral nephrectomy for 48 h. In rats with chronic intra-arterial and intravenous catheters, cardiovascular reflexes and the renin-angiotensin system were blocked with atropine, pentolinium, and a converting-enzyme inhibitor, respectively. Atropine 200-208 renin Rattus norvegicus 157-162 3521182-2 1986 Treatment with a chloride-deficient diet led to a temporary decrease in the capsular adrenal conversions of corticosterone to 18-hydroxycorticosterone and aldosterone (manifest after 2 weeks but not longer apparent after 3 weeks), which was accompanied by a progressive rise in plasma renin activity and a moderate fall in plasma potassium. Corticosterone 108-122 renin Rattus norvegicus 285-290 3521182-3 1986 Combined restriction of sodium, potassium and chloride elicited a decreased activity of the enzyme(s) involved in late steps in aldosterone biosynthesis, an elevation of plasma renin activity to excessively high levels and a substantial hypokalaemia. Sodium 24-30 renin Rattus norvegicus 177-182 3516870-5 1986 Acute urine output, sodium excretion, and plasma renin activity in response to a saline load were not different between sham-operated and denervated SHR. Sodium Chloride 81-87 renin Rattus norvegicus 49-54 2871468-1 1986 Dopamine affects renal hemodynamics, renal tubular functions, and the secretion of renin. Dopamine 0-8 renin Rattus norvegicus 83-88 2874518-1 1986 p-Chloroamphetamine (PCA) which releases serotonin is known to increase the activity of plasma renin in conscious rats by stimulating serotonergic neurotransmission in the brain. p-Chloroamphetamine 0-19 renin Rattus norvegicus 95-100 2874518-1 1986 p-Chloroamphetamine (PCA) which releases serotonin is known to increase the activity of plasma renin in conscious rats by stimulating serotonergic neurotransmission in the brain. p-Chloroamphetamine 21-24 renin Rattus norvegicus 95-100 2874518-1 1986 p-Chloroamphetamine (PCA) which releases serotonin is known to increase the activity of plasma renin in conscious rats by stimulating serotonergic neurotransmission in the brain. Serotonin 41-50 renin Rattus norvegicus 95-100 2874518-3 1986 The effect of PCA on the activity of plasma renin was completely blocked by the beta receptor blockers sotalol and atenolol, but was not prevented by the sympathetic inhibitor, bretylium tosylate. Sotalol 103-110 renin Rattus norvegicus 44-49 2874518-3 1986 The effect of PCA on the activity of plasma renin was completely blocked by the beta receptor blockers sotalol and atenolol, but was not prevented by the sympathetic inhibitor, bretylium tosylate. Atenolol 115-123 renin Rattus norvegicus 44-49 2874518-8 1986 The role of the parasympathetic nervous system in the rise in the activity of plasma renin induced by PCA was investigated by pretreatment of the rats with the peripheral muscarinic receptor blocker, methyl atropine. methylatropine 200-215 renin Rattus norvegicus 85-90 3008566-1 1986 It was the aim of the present study to get insight into some of the intracellular mechanisms by which the vasoconstrictor hormones angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE) inhibit renin release from renal juxtaglomerular cells. Norepinephrine 188-202 renin Rattus norvegicus 216-221 3518445-7 1986 Instead, the absence of ADH per se may directly alter renin secretion or the sensitivity of the granular cell to other stimuli. adh 24-27 renin Rattus norvegicus 54-59 3008566-5 1986 Both the effects on renin release and on calcium permeability could be diminished or even be abolished by the calcium channel blocker verapamil (Vp) (10(-5) M). Verapamil 134-143 renin Rattus norvegicus 20-25 3008566-5 1986 Both the effects on renin release and on calcium permeability could be diminished or even be abolished by the calcium channel blocker verapamil (Vp) (10(-5) M). Verapamil 145-147 renin Rattus norvegicus 20-25 3008566-7 1986 Moreover, a direct stimulation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) (10(-8)-10(-6) M) also inhibited renin release and increased the calcium permeability of the cell membrane. Tetradecanoylphorbol Acetate 41-77 renin Rattus norvegicus 117-122 3521516-6 1986 Plasma renin activity was markedly higher in adrenalectomized rats than in the sham-operated rats even after sodium supplementation. Sodium 109-115 renin Rattus norvegicus 7-12 3008566-7 1986 Moreover, a direct stimulation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) (10(-8)-10(-6) M) also inhibited renin release and increased the calcium permeability of the cell membrane. Tetradecanoylphorbol Acetate 79-82 renin Rattus norvegicus 117-122 3008566-9 1986 In conclusion, these results point toward a common mechanism by which vasoconstrictors inhibit renin release from renal juxtaglomerular cells: ANG II, AVP, and NE activate a phospholipase C, which generates DAG. Diglycerides 207-210 renin Rattus norvegicus 95-100 3524919-0 1986 Effect of sodium intake and sodium delivery to the macula densa on renal renin content and juxtaglomerular apparatus morphology. Sodium 28-34 renin Rattus norvegicus 73-78 3524919-8 1986 Increased delivery of NaCl to the macula densa did not alter total renin, but decreased inactive renin from 30% to 0, crystalline core-containing cells from 33% to 14% and decreased the percentage of granules with crystalline cores from 12% to 2.2%. Sodium Chloride 22-26 renin Rattus norvegicus 97-102 3015458-4 1986 In the pithed rat tetradecapeptide renin substrate increased blood pressure and this effect was reduced by the converting enzyme inhibitor, captopril. Captopril 140-149 renin Rattus norvegicus 35-40 3524919-9 1986 Increased sodium in the diet and increased delivery of NaCl to the macula densa decreased the proportion of renin present in the inactive form and decreased the proportion of crystalline cores. Sodium 10-16 renin Rattus norvegicus 108-113 3524919-9 1986 Increased sodium in the diet and increased delivery of NaCl to the macula densa decreased the proportion of renin present in the inactive form and decreased the proportion of crystalline cores. Sodium Chloride 55-59 renin Rattus norvegicus 108-113 3524919-10 1986 These coincidental alterations suggest that crystalline cores contain inactive renin and suggest that the delivery of sodium to the macula densa activates renin. Sodium 118-124 renin Rattus norvegicus 155-160 3005789-3 1986 It was observed that isoproterenol and epinephrine stimulated renin secretion and that clonidine decreased both basal and isoproterenol-stimulated renin secretion in the control group. Isoproterenol 21-34 renin Rattus norvegicus 62-67 3519764-2 1986 The administration of 0.9% sodium chloride as a drinking solution for 3 weeks suppressed plasma renin activity (PRA) and kidney renin content of the clipped kidney to normal values. Sodium Chloride 27-42 renin Rattus norvegicus 96-101 3519764-2 1986 The administration of 0.9% sodium chloride as a drinking solution for 3 weeks suppressed plasma renin activity (PRA) and kidney renin content of the clipped kidney to normal values. Sodium Chloride 27-42 renin Rattus norvegicus 128-133 3519764-6 1986 Thus, the high-salt intake which was associated with suppression of the activity of the renin-angiotensin system delayed the onset of, but not the final magnitude of, the hypertension. Salts 15-19 renin Rattus norvegicus 88-93 3011890-8 1986 These data indicate that during hypo- and hypernatraemic dehydration, the renin-angiotensin system plays a role in regulating blood pressure, urea elimination and plasma aldosterone, but vasopressin regulation is not modified by its inhibition. Urea 142-146 renin Rattus norvegicus 74-79 3005789-3 1986 It was observed that isoproterenol and epinephrine stimulated renin secretion and that clonidine decreased both basal and isoproterenol-stimulated renin secretion in the control group. Epinephrine 39-50 renin Rattus norvegicus 62-67 3005789-3 1986 It was observed that isoproterenol and epinephrine stimulated renin secretion and that clonidine decreased both basal and isoproterenol-stimulated renin secretion in the control group. Clonidine 87-96 renin Rattus norvegicus 147-152 3005789-3 1986 It was observed that isoproterenol and epinephrine stimulated renin secretion and that clonidine decreased both basal and isoproterenol-stimulated renin secretion in the control group. Isoproterenol 122-135 renin Rattus norvegicus 147-152 3513627-6 1986 Serum renin activity (SRA) also increased in both strains receiving PEG at 6 and 8 wk of age, but the response was suppressed in the SHR relative to the WKY (P less than 0.001). Polyethylene Glycols 68-71 renin Rattus norvegicus 6-11 3512818-1 1986 The influence of interrupting the renin-angiotensin system on the renal hemodynamic response to barbiturate anesthesia was assessed in conscious, trained, chronically catheterized rats. barbituric acid 96-107 renin Rattus norvegicus 34-39 3512345-8 1986 The dose-response curve of renin secretion (as a proportion of total renal content) in response to isoproterenol was shifted downward. Isoproterenol 99-112 renin Rattus norvegicus 27-32 3512345-9 1986 Hence, while KRC and spontaneous RR by isolated, perfused kidneys were increased, the increment in PRA with salt depletion and the renin-secretory response to isoproterenol in vitro were impaired. Isoproterenol 159-172 renin Rattus norvegicus 131-136 3512818-9 1986 At 100 min after administration of pentobarbital, plasma renin activity was elevated compared to a conscious control group (3.57 +/- 0.42 vs. 1.94 +/- 0.34 ng angiotensin l/ml X hr, P less than .05). Pentobarbital 35-48 renin Rattus norvegicus 57-62 3512818-10 1986 It is concluded that the renin-angiotensin system mediates an impairment of renal hemodynamics during pentobarbital anesthesia. Pentobarbital 102-115 renin Rattus norvegicus 25-30 3513052-1 1986 Conscious, adult, water-deprived Brattleboro rats treated neonatally with capsaicin or vehicle showed similar hypotensive responses to sequential inhibition of the renin-angiotensin system (with captopril) and antagonism of ganglionic transmission (with pentolinium). Capsaicin 74-83 renin Rattus norvegicus 164-169 3710315-10 1986 Plasma renin activities measured after 17 weeks treatment of the drugs indicated that the renin-angiotensin system was activated by hydrochlorothiazide. Hydrochlorothiazide 132-151 renin Rattus norvegicus 7-12 3710315-10 1986 Plasma renin activities measured after 17 weeks treatment of the drugs indicated that the renin-angiotensin system was activated by hydrochlorothiazide. Hydrochlorothiazide 132-151 renin Rattus norvegicus 90-95 3710315-11 1986 These results suggest that the antihypertensive effect of long-term administration of SA446 in SHR is enhanced by the combined administration of diuretics such as hydrochlorothiazide, which activates the renin-angiotensin system. rentiapril 86-91 renin Rattus norvegicus 204-209 3710315-11 1986 These results suggest that the antihypertensive effect of long-term administration of SA446 in SHR is enhanced by the combined administration of diuretics such as hydrochlorothiazide, which activates the renin-angiotensin system. Hydrochlorothiazide 163-182 renin Rattus norvegicus 204-209 3009208-2 1986 Basal levels of plasma renin activity of both types of hypertensive rats were suppressed by sodium loading. Sodium 92-98 renin Rattus norvegicus 23-28 3511734-4 1986 Plasma renin activity (PRA) was elevated fourfold after 6 wk of sodium restriction and was unchanged by renal denervation. Sodium 64-70 renin Rattus norvegicus 7-12 3511220-0 1986 Extracellular strontium substitutes for calcium in in vitro renin secretion. Calcium 40-47 renin Rattus norvegicus 60-65 3511220-1 1986 It has been shown previously that ouabain, vanadate, angiotensin II and 0 and 60 mM KCl media have Ca-dependent inhibitory effects on renin secretory rates of rat renal cortical slices. Vanadates 43-51 renin Rattus norvegicus 134-139 3511220-1 1986 It has been shown previously that ouabain, vanadate, angiotensin II and 0 and 60 mM KCl media have Ca-dependent inhibitory effects on renin secretory rates of rat renal cortical slices. Potassium Chloride 84-87 renin Rattus norvegicus 134-139 3511220-4 1986 The inhibitory effects and methoxyverapamil-induced antagonism of the inhibitory effect of K-depolarization, suggest that increased intracellular Sr++ can lead to inhibition of renin secretion, perhaps directly or perhaps by causing the release or mobilization of Ca++ from intracellular sites of binding or sequestration. Gallopamil 27-43 renin Rattus norvegicus 177-182 3511220-4 1986 The inhibitory effects and methoxyverapamil-induced antagonism of the inhibitory effect of K-depolarization, suggest that increased intracellular Sr++ can lead to inhibition of renin secretion, perhaps directly or perhaps by causing the release or mobilization of Ca++ from intracellular sites of binding or sequestration. Strontium 146-150 renin Rattus norvegicus 177-182 3006413-2 1986 Heparin-treated rats had low plasma aldosterone levels, high plasma renin activity and plasma AII levels, and normal plasma corticosterone level 6 weeks after the treatment (1500 IU/kg, twice daily). Heparin 0-7 renin Rattus norvegicus 68-73 3513052-5 1986 Long-Evans rats treated neonatally with capsaicin may be due to less effective compensation for inhibition of the renin-angiotensin system when vasopressin release is impaired. Capsaicin 40-49 renin Rattus norvegicus 114-119 3532691-0 1986 Renin-angiotensin system and renal excretory function under conditions of hypovolemia and limited sodium intake. Sodium 98-104 renin Rattus norvegicus 0-5 3766163-4 1986 After sodium depletion significant activation of renin-angiotensin-aldosterone system and insignificantly increased kallikrein excretion without changes in prostaglandin excretion and plasma vasopressin were found. Sodium 6-12 renin Rattus norvegicus 49-54 3544714-3 1986 Inactivation of kallikrein by PMSF or inhibition with aprotinin blocked kallikrein stimulation of renin release. Phenylmethylsulfonyl Fluoride 30-34 renin Rattus norvegicus 98-103 3030046-5 1986 Similar changes were observed in SCN rats 24 hours after water deprivation and in intact rats 48 hours after serotonin depletion by pCPA: suppressed renin activity together with increased aldosterone concentration. Serotonin 109-118 renin Rattus norvegicus 149-154 3030046-5 1986 Similar changes were observed in SCN rats 24 hours after water deprivation and in intact rats 48 hours after serotonin depletion by pCPA: suppressed renin activity together with increased aldosterone concentration. Fenclonine 132-136 renin Rattus norvegicus 149-154 2876791-0 1986 Brain renin angiotensin system contributes to the salt-induced enhancement of hypertension in SHR. Salts 50-54 renin Rattus norvegicus 6-11 2876791-1 1986 The study was performed to determine whether the brain renin angiotensin system may contribute to the acceleration in hypertension following long-term salt loading in spontaneously hypertensive rats (SHR). Salts 151-155 renin Rattus norvegicus 55-60 2876791-9 1986 The plasma renin concentration (PRC) in both SHR and WKY was significantly suppressed by the salt load. Salts 93-97 renin Rattus norvegicus 11-16 3708936-6 1986 There was increased renin secretion from the CSA-treated rats, compared to controls, and the response was dose-dependent. Cyclosporine 45-48 renin Rattus norvegicus 20-25 3519027-3 1986 CyA was found to suppress feeding and drinking and, as a result, lead to volume depletion and weight loss, with a corresponding lowering of blood pressure and renal function and an increase in plasma renin. Cyclosporine 0-3 renin Rattus norvegicus 200-205 2876791-10 1986 The present results suggest that long-term salt overload may result in the enhanced activity of brain renin angiotensin system, which could be responsible for the exaggerated development of hypertension in SHR. Salts 43-47 renin Rattus norvegicus 102-107 3708936-9 1986 In animals not pretreated with CSA, the renal cortical slices incubated with CSA demonstrated a stimulation of renin release. Cyclosporine 77-80 renin Rattus norvegicus 111-116 2949895-1 1986 Adult rats treated neonatally with guanethidine had normal arterial blood pressures, but these were more dependent on the renin-angiotensin system than in control animals. Guanethidine 35-47 renin Rattus norvegicus 122-127 3708936-11 1986 This data indicates that the renal renin-angiotensin system is activated by CSA and produces a dissociation of the linkage between renal slice prostaglandin release and the renin angiotensin system. Cyclosporine 76-79 renin Rattus norvegicus 35-40 3708936-11 1986 This data indicates that the renal renin-angiotensin system is activated by CSA and produces a dissociation of the linkage between renal slice prostaglandin release and the renin angiotensin system. prostaglandin release 143-164 renin Rattus norvegicus 35-40 2438484-3 1986 Renin expression in kidney, heart, and adrenal are stimulated by sodium depletion and beta-adrenergic agonist. Sodium 65-71 renin Rattus norvegicus 0-5 3510973-0 1986 Effect of dietary chloride on salt-sensitive and renin-dependent hypertension. Chlorides 18-26 renin Rattus norvegicus 49-54 3510973-1 1986 We have previously reported that 1) selective dietary sodium loading (without chloride) does not produce hypertension in rats of the Dahl salt-sensitive strain (DS) and 2) selective chloride loading (without sodium) lowers plasma renin activity in the intact Sprague-Dawley rat maintained on a low NaCl diet. Chlorides 182-190 renin Rattus norvegicus 230-235 2434771-4 1986 Inhibition of the renin-angiotensin system following administration of d(CH2)5DAVP causes a greater hypotension in PEG-treated than in water-deprived Long-Evans rats. Polyethylene Glycols 115-118 renin Rattus norvegicus 18-23 2434771-4 1986 Inhibition of the renin-angiotensin system following administration of d(CH2)5DAVP causes a greater hypotension in PEG-treated than in water-deprived Long-Evans rats. Water 135-140 renin Rattus norvegicus 18-23 2438493-10 1986 Addition of 1 mM (final concentration) calcium resulted in a ninefold increase in mesangial renin activity from 21 +/- 8 to 185 +/- 10 pg ANG I/h/10(5) cells (n = 4, p less than 0.001). Calcium 39-46 renin Rattus norvegicus 92-97 2438493-12 1986 Thus, mesangial cells synthesize renin, which can be regulated by beta-adrenergic receptors and extracellular calcium. Calcium 110-117 renin Rattus norvegicus 33-38 2439793-6 1986 Bisoprolol lowered BP in hypertensive dogs and rats, attenuated the development of spontaneous hypertension in rats, decreased plasma renin activity and protected the heart from the sequelae of transient ischemia. Bisoprolol 0-10 renin Rattus norvegicus 134-139 2438484-8 1986 Sodium depletion stimulates renin angiotensinogen mRNA expression but does not influence hepatic angiotensinogen mRNA levels. Sodium 0-6 renin Rattus norvegicus 28-33 2438493-7 1986 Mesangial immunoreactive renin activity is influenced by beta-adrenergic stimulation and increased extracellular calcium. Calcium 113-120 renin Rattus norvegicus 25-30 2438493-9 1986 Addition of calcium to culture media for 1 h resulted in an increase in intracellular renin activity. Calcium 12-19 renin Rattus norvegicus 86-91 2879065-6 1986 Inhibition of renin release from the JG-cells by ANP was clearly correlated to the level of cGMPi and not to the level of cAMPi. cgmpi 92-97 renin Rattus norvegicus 14-19 3529266-0 1986 Biphasic alteration of renin-angiotensin-aldosterone system in streptozotocin-diabetic rats. Streptozocin 63-77 renin Rattus norvegicus 23-28 2433720-5 1986 The inhibitory effect of high-perfusion pressure on renin secretion was attenuated by the calcium entry blocker verapamil but not by nifedipine. Verapamil 112-121 renin Rattus norvegicus 52-57 3005899-1 1986 The role of the brain renin-angiotensin system in the ACTH response to ether stress in rats was investigated by injecting the angiotensin II receptor blocking drug saralasin, the angiotensin II converting enzyme inhibitors enalaprilat and captopril, and the renin inhibitor L 363714 intraventricularly and measuring the ACTH and corticosterone concentration in plasma 10 min after ether stress. Ether 71-76 renin Rattus norvegicus 22-27 3005899-2 1986 ACTH and corticosterone were elevated to at least the same level in rats treated with the inhibitors as they were in rats treated with the corresponding vehicles; indeed, ACTH values were somewhat greater in stressed rats treated with the converting enzyme inhibitors and the renin inhibitor. Corticosterone 9-23 renin Rattus norvegicus 276-281 3513258-6 1986 Renin release from cortical slices of ADX rats given dexamethasone (10 micrograms/kg/day) for 4 days prior to sacrifice did not differ from sham-operated control values. Dexamethasone 53-66 renin Rattus norvegicus 0-5 3018876-0 1986 Renin granules isolated from rat kidney cortex by continuous colloidal silica (Percoll) density gradient centrifugation. Silicon Dioxide 71-77 renin Rattus norvegicus 0-5 3018876-1 1986 Renin granules were isolated from rat kidney cortex by a continuous polyvinyl-pyrrolidone-coated colloidal silica (Percoll) density gradient centrifugation. Povidone 68-89 renin Rattus norvegicus 0-5 3018876-1 1986 Renin granules were isolated from rat kidney cortex by a continuous polyvinyl-pyrrolidone-coated colloidal silica (Percoll) density gradient centrifugation. Silicon Dioxide 107-113 renin Rattus norvegicus 0-5 3529266-1 1986 The alteration of renin-angiotensin-aldosterone system caused by diabetes mellitus was studied in streptozotocin-diabetic rats. Streptozocin 98-112 renin Rattus norvegicus 18-23 3935895-1 1985 It has been shown previously that in vitro renin secretion is inhibited by partial replacement of extracellular NaCl with either mannitol or choline chloride; the inhibitory effect is attributed to an increase in intracellular Ca, resulting from a decreased rate of Ca efflux via Na-Ca exchange. Sodium Chloride 112-116 renin Rattus norvegicus 43-48 3935895-1 1985 It has been shown previously that in vitro renin secretion is inhibited by partial replacement of extracellular NaCl with either mannitol or choline chloride; the inhibitory effect is attributed to an increase in intracellular Ca, resulting from a decreased rate of Ca efflux via Na-Ca exchange. Mannitol 129-137 renin Rattus norvegicus 43-48 3912207-5 1985 Treatment with either trypsin or glandular kallikrein of the brain tissue extract caused a rapid and apparent increase in the renin activity at either 0 or 27 degrees C. The molecular weight of the active renin was estimated to be 41,000 or 50,000 daltons, while that of the trypsin-activatable inactive renin was found to be 44,000 or 57,000 daltons on a column chromatography with Sephadex G-100. sephadex 383-397 renin Rattus norvegicus 126-131 3912207-5 1985 Treatment with either trypsin or glandular kallikrein of the brain tissue extract caused a rapid and apparent increase in the renin activity at either 0 or 27 degrees C. The molecular weight of the active renin was estimated to be 41,000 or 50,000 daltons, while that of the trypsin-activatable inactive renin was found to be 44,000 or 57,000 daltons on a column chromatography with Sephadex G-100. sephadex 383-397 renin Rattus norvegicus 205-210 3935895-1 1985 It has been shown previously that in vitro renin secretion is inhibited by partial replacement of extracellular NaCl with either mannitol or choline chloride; the inhibitory effect is attributed to an increase in intracellular Ca, resulting from a decreased rate of Ca efflux via Na-Ca exchange. Choline 141-157 renin Rattus norvegicus 43-48 3912207-5 1985 Treatment with either trypsin or glandular kallikrein of the brain tissue extract caused a rapid and apparent increase in the renin activity at either 0 or 27 degrees C. The molecular weight of the active renin was estimated to be 41,000 or 50,000 daltons, while that of the trypsin-activatable inactive renin was found to be 44,000 or 57,000 daltons on a column chromatography with Sephadex G-100. sephadex 383-397 renin Rattus norvegicus 205-210 3935895-2 1985 In the present experiments, we confirmed that partially replacing NaCl with choline chloride inhibited renin secretion from rat renal cortical slices, but we found that atropine completely blocked the effect, suggesting cholinergic mediation. Sodium Chloride 66-70 renin Rattus norvegicus 103-108 3935895-2 1985 In the present experiments, we confirmed that partially replacing NaCl with choline chloride inhibited renin secretion from rat renal cortical slices, but we found that atropine completely blocked the effect, suggesting cholinergic mediation. Choline 76-92 renin Rattus norvegicus 103-108 3935895-3 1985 Partially replacing NaCl with mannitol also inhibited renin secretion, but the effect could not be attributed specifically to a reduction in extracellular Na. Sodium Chloride 20-24 renin Rattus norvegicus 54-59 3935895-3 1985 Partially replacing NaCl with mannitol also inhibited renin secretion, but the effect could not be attributed specifically to a reduction in extracellular Na. Mannitol 30-38 renin Rattus norvegicus 54-59 3935895-4 1985 Moreover, the stimulatory effect of Ca chelation on renin secretion was antagonized by either mannitol- or choline chloride -containing incubation media. Mannitol 94-102 renin Rattus norvegicus 52-57 3935895-4 1985 Moreover, the stimulatory effect of Ca chelation on renin secretion was antagonized by either mannitol- or choline chloride -containing incubation media. Choline 107-123 renin Rattus norvegicus 52-57 3003190-10 1985 Both the fall in pressure after acute captopril and that after chronic captopril were related to pre-treatment levels of plasma renin concentration. Captopril 38-47 renin Rattus norvegicus 128-133 3878075-6 1985 Diltiazem increased plasma renin activity but had no influence on plasma aldosterone concentration. Diltiazem 0-9 renin Rattus norvegicus 27-32 3878075-7 1985 Hydralazine increased both plasma renin activity and plasma aldosterone concentration and decreased sodium excretion. Hydralazine 0-11 renin Rattus norvegicus 34-39 2420298-0 1985 Blood pressure and renin responses to captopril in anesthetized rats pretreated with indomethacin or aprotinin. Captopril 38-47 renin Rattus norvegicus 19-24 2420298-0 1985 Blood pressure and renin responses to captopril in anesthetized rats pretreated with indomethacin or aprotinin. Indomethacin 85-97 renin Rattus norvegicus 19-24 2420298-1 1985 The present study was done to investigate the role of endogenous prostaglandins and kinins in the mechanism of captopril-induced hypotensive effect and stimulating effect of plasma renin activity (PRA) in pentobarbital-anesthetized rats. Prostaglandins 65-79 renin Rattus norvegicus 181-186 2420298-1 1985 The present study was done to investigate the role of endogenous prostaglandins and kinins in the mechanism of captopril-induced hypotensive effect and stimulating effect of plasma renin activity (PRA) in pentobarbital-anesthetized rats. Pentobarbital 205-218 renin Rattus norvegicus 181-186 2856715-0 1985 The effect of sodium intake on the renin response to dopamine in superfused rat renal cortical cells. Sodium 14-20 renin Rattus norvegicus 35-40 2856715-0 1985 The effect of sodium intake on the renin response to dopamine in superfused rat renal cortical cells. Dopamine 53-61 renin Rattus norvegicus 35-40 2856715-5 1985 Rats on a low sodium diet showed a higher basal cellular renin release and an enhanced renin response to dopamine (10(-7), 10(-6) mol/l) compared with the normal sodium diet group. Sodium 14-20 renin Rattus norvegicus 57-62 2856715-5 1985 Rats on a low sodium diet showed a higher basal cellular renin release and an enhanced renin response to dopamine (10(-7), 10(-6) mol/l) compared with the normal sodium diet group. Sodium 14-20 renin Rattus norvegicus 87-92 2856715-5 1985 Rats on a low sodium diet showed a higher basal cellular renin release and an enhanced renin response to dopamine (10(-7), 10(-6) mol/l) compared with the normal sodium diet group. Dopamine 105-113 renin Rattus norvegicus 87-92 2856715-6 1985 Rats on a high sodium diet, in contrast, showed a lower cellular renin release and a decreased sensitivity to dopamine (10(-7), 10(-6) mol/l) compared with the normal sodium diet group. Sodium 15-21 renin Rattus norvegicus 65-70 2856715-7 1985 These results demonstrate that the renin response to dopamine is dependent upon sodium intake. Dopamine 53-61 renin Rattus norvegicus 35-40 2856715-7 1985 These results demonstrate that the renin response to dopamine is dependent upon sodium intake. Sodium 80-86 renin Rattus norvegicus 35-40 3913755-8 1985 Afferent and efferent renal nerve activity appear to be closely related since recent experiments by our group have provided further evidence of the existence of neural renorenal reflexes by which one kidney exerts a tonic inhibitory effect on the release of renin from juxtaglomerular cells and on tubular sodium and water reabsorption of the contralateral kidney. Sodium 306-312 renin Rattus norvegicus 258-263 3913393-0 1985 Involvement of the renin-angiotensin system in the dipsogenic effect of morphine. Morphine 72-80 renin Rattus norvegicus 19-24 3913393-4 1985 In such renin-depleted rats with subnormal plasma renin levels, morphine and isoprenaline-induced water intakes were linearly related to pre-injection basal plasma renin level. Morphine 64-72 renin Rattus norvegicus 8-13 3913393-4 1985 In such renin-depleted rats with subnormal plasma renin levels, morphine and isoprenaline-induced water intakes were linearly related to pre-injection basal plasma renin level. Isoproterenol 77-89 renin Rattus norvegicus 8-13 3913393-4 1985 In such renin-depleted rats with subnormal plasma renin levels, morphine and isoprenaline-induced water intakes were linearly related to pre-injection basal plasma renin level. Isoproterenol 77-89 renin Rattus norvegicus 50-55 3913393-4 1985 In such renin-depleted rats with subnormal plasma renin levels, morphine and isoprenaline-induced water intakes were linearly related to pre-injection basal plasma renin level. Isoproterenol 77-89 renin Rattus norvegicus 50-55 3913393-4 1985 In such renin-depleted rats with subnormal plasma renin levels, morphine and isoprenaline-induced water intakes were linearly related to pre-injection basal plasma renin level. Water 98-103 renin Rattus norvegicus 8-13 3913393-6 1985 These results pointed to the existence of a permissive interaction between morphine and the renin-angiotensin system. Morphine 75-83 renin Rattus norvegicus 92-97 3913393-8 1985 We interpreted this drinking response as being the sum of morphine-induced drinking (following a permissive interaction between morphine and circulating angiotensin I or renin) and captopril-induced drinking (following a captopril-induced increase in circulating renin and angiotensin I levels). Captopril 221-230 renin Rattus norvegicus 263-268 3913393-10 1985 This result pointed once again to a permissive interaction between morphine and circulating angiotensin I or renin. Morphine 67-75 renin Rattus norvegicus 109-114 2868056-6 1985 methoxamine (10 micrograms/kg) and phenylephrine (30 micrograms/kg) also increased plasma levels of arginine vasopressin (AVP) in LE rats from 2.6 +/- 0.4 (n = 9) to 22.4 +/- 3.5 (n = 6, P less than 0.01) and 37.0 +/- 4.0 pg/ml (n = 6, P less than 0.01), respectively, without affecting plasma renin activity (PRA) and plasma angiotensin II (ANG II) levels. Methoxamine 0-11 renin Rattus norvegicus 294-299 2868056-6 1985 methoxamine (10 micrograms/kg) and phenylephrine (30 micrograms/kg) also increased plasma levels of arginine vasopressin (AVP) in LE rats from 2.6 +/- 0.4 (n = 9) to 22.4 +/- 3.5 (n = 6, P less than 0.01) and 37.0 +/- 4.0 pg/ml (n = 6, P less than 0.01), respectively, without affecting plasma renin activity (PRA) and plasma angiotensin II (ANG II) levels. Phenylephrine 35-48 renin Rattus norvegicus 294-299 3913755-8 1985 Afferent and efferent renal nerve activity appear to be closely related since recent experiments by our group have provided further evidence of the existence of neural renorenal reflexes by which one kidney exerts a tonic inhibitory effect on the release of renin from juxtaglomerular cells and on tubular sodium and water reabsorption of the contralateral kidney. Water 317-322 renin Rattus norvegicus 258-263 3003190-10 1985 Both the fall in pressure after acute captopril and that after chronic captopril were related to pre-treatment levels of plasma renin concentration. Captopril 71-80 renin Rattus norvegicus 128-133 3842021-6 1985 Full suppression of plasma renin activity (PRA) was observed with 0.1 and 0.5 microgram/day 19-nor-aldosterone, whereas Aldo caused similar decreases in PRA only at dosages of 0.5 microgram/day and higher. 19-noraldosterone 92-110 renin Rattus norvegicus 27-32 3912871-0 1985 [Effect of the administration of 5,6-dihydroxytryptamine to the amygdala and dorsal raphe nucleus on plasma renin activity]. 5,6-Dihydroxytryptamine 33-56 renin Rattus norvegicus 108-113 3912871-1 1985 The effect of injections of 5,6-dihydroxytryptamine, a potent and selective neurotoxic of serotonin neurons, into amygdala and dorsal raphe mesencephalic nucleus on the plasma renin activity has been studied in male Wistar rats. 5,6-Dihydroxytryptamine 28-51 renin Rattus norvegicus 176-181 3912871-3 1985 The administration of 5,6-dihydroxytryptamine in amigdala produced a significant decrease in plasmatic renin activity between 2nd and 4th day, but the inverse effect between 7th and 14th day. 5,6-Dihydroxytryptamine 22-45 renin Rattus norvegicus 103-108 3908312-5 1985 After 15 days of sodium depletion and captopril treatment, plasma renin concentration increased 46-fold, renal renin concentration only 1.5-fold, and renin mRNA content increased about threefold. Sodium 17-23 renin Rattus norvegicus 66-71 2416580-0 1985 The calcium channel agonist, Bay K 8644, inhibits renin release from rat kidney cortical slices. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 29-39 renin Rattus norvegicus 50-55 2416580-1 1985 The effects of Bay K 8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate], a calcium channel agonist, on renin release in rat kidney cortical slices were examined. methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate 27-118 renin Rattus norvegicus 151-156 2416580-2 1985 Bay K 8644 produced a dose-related inhibition of renin release in the presence of 15 mM potassium. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 0-10 renin Rattus norvegicus 49-54 2416580-2 1985 Bay K 8644 produced a dose-related inhibition of renin release in the presence of 15 mM potassium. Potassium 88-97 renin Rattus norvegicus 49-54 2416580-4 1985 Nifedipine exerted a concentration-dependent blocking action on the inhibition of renin release by Bay K 8644. Nifedipine 0-10 renin Rattus norvegicus 82-87 2416580-4 1985 Nifedipine exerted a concentration-dependent blocking action on the inhibition of renin release by Bay K 8644. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 99-109 renin Rattus norvegicus 82-87 2416580-5 1985 These findings support the proposal that calcium influx into the renin secretory cells is an inhibitory signal for renin release. Calcium 41-48 renin Rattus norvegicus 65-70 2416580-5 1985 These findings support the proposal that calcium influx into the renin secretory cells is an inhibitory signal for renin release. Calcium 41-48 renin Rattus norvegicus 115-120 3908312-5 1985 After 15 days of sodium depletion and captopril treatment, plasma renin concentration increased 46-fold, renal renin concentration only 1.5-fold, and renin mRNA content increased about threefold. Captopril 38-47 renin Rattus norvegicus 66-71 3908312-5 1985 After 15 days of sodium depletion and captopril treatment, plasma renin concentration increased 46-fold, renal renin concentration only 1.5-fold, and renin mRNA content increased about threefold. Captopril 38-47 renin Rattus norvegicus 111-116 3908312-5 1985 After 15 days of sodium depletion and captopril treatment, plasma renin concentration increased 46-fold, renal renin concentration only 1.5-fold, and renin mRNA content increased about threefold. Captopril 38-47 renin Rattus norvegicus 111-116 3908312-6 1985 Following a 1-hour infusion of angiotensin II in sodium-depleted and captopril-treated rats, plasma renin concentration decreased by 84% whereas no significant changes in either renal renin concentration or renin mRNA content were observed. Sodium 49-55 renin Rattus norvegicus 100-105 3908312-6 1985 Following a 1-hour infusion of angiotensin II in sodium-depleted and captopril-treated rats, plasma renin concentration decreased by 84% whereas no significant changes in either renal renin concentration or renin mRNA content were observed. Captopril 69-78 renin Rattus norvegicus 100-105 3908312-7 1985 These results show that sodium depletion and captopril treatment increase the level of renin gene transcription and renin biosynthesis. Sodium 24-30 renin Rattus norvegicus 87-92 3908312-7 1985 These results show that sodium depletion and captopril treatment increase the level of renin gene transcription and renin biosynthesis. Sodium 24-30 renin Rattus norvegicus 116-121 3899615-0 1985 A role for the adrenal renin-angiotensin system in the regulation of potassium-stimulated aldosterone production. Potassium 69-78 renin Rattus norvegicus 23-28 3899615-0 1985 A role for the adrenal renin-angiotensin system in the regulation of potassium-stimulated aldosterone production. Aldosterone 90-101 renin Rattus norvegicus 23-28 3899615-3 1985 The causal relationship between potassium and adrenal renin is not known. Potassium 32-41 renin Rattus norvegicus 54-59 3899615-7 1985 In intact animals potassium loading markedly increased adrenal renin and plasma aldosterone, whereas PRA was suppressed. Potassium 18-27 renin Rattus norvegicus 63-68 3899615-11 1985 These results suggest that the adrenal renin-ANG system plays a significant role in the control of aldosterone production under potassium stimulation. Aldosterone 99-110 renin Rattus norvegicus 39-44 3899615-11 1985 These results suggest that the adrenal renin-ANG system plays a significant role in the control of aldosterone production under potassium stimulation. Potassium 128-137 renin Rattus norvegicus 39-44 3908312-7 1985 These results show that sodium depletion and captopril treatment increase the level of renin gene transcription and renin biosynthesis. Captopril 45-54 renin Rattus norvegicus 87-92 3908312-7 1985 These results show that sodium depletion and captopril treatment increase the level of renin gene transcription and renin biosynthesis. Captopril 45-54 renin Rattus norvegicus 116-121 3900613-3 1985 Administration of the serotonin releaser dl-p-chloroamphetamine-HCl (PCA) to rats causes dose-dependent increases in renin secretion that can be blocked by serotonin depletion with p-chlorophenylalanine (PCPA), injections of 5,7-dihydroxytryptamine into the dorsal raphe nucleus or ablation of the mediobasal hypothalamus. pca 69-72 renin Rattus norvegicus 117-122 3902894-1 1985 Effects of dietary sodium chloride intake on brain renin. Sodium Chloride 19-34 renin Rattus norvegicus 51-56 3902894-6 1985 NaCl depletion increased renin activity in selected regions; based on estimates of residual plasma contamination (despite perfusion of brains with saline), increased renin activity of pineal gland and posterior pituitary was attributed to higher plasma renin. Sodium Chloride 0-4 renin Rattus norvegicus 25-30 3902894-6 1985 NaCl depletion increased renin activity in selected regions; based on estimates of residual plasma contamination (despite perfusion of brains with saline), increased renin activity of pineal gland and posterior pituitary was attributed to higher plasma renin. Sodium Chloride 0-4 renin Rattus norvegicus 166-171 3902894-6 1985 NaCl depletion increased renin activity in selected regions; based on estimates of residual plasma contamination (despite perfusion of brains with saline), increased renin activity of pineal gland and posterior pituitary was attributed to higher plasma renin. Sodium Chloride 0-4 renin Rattus norvegicus 166-171 3902894-8 1985 In anephric rats, NaCl depletion increased renin activity by 92% in olfactory bulbs and by 97% in anterior pituitary compared with NaCl-replete state. Sodium Chloride 18-22 renin Rattus norvegicus 43-48 3902894-13 1985 We conclude that (a) NaCl deprivation increases renin in olfactory bulbs and anterior pituitary of the rat, unrelated to contamination by plasma renin; and (b) the existence of angiotensinogen, the precursor of angiotensins, is demonstrated by direct radioimmunoassay throughout the brain and in neuroendocrine glands. Sodium Chloride 21-25 renin Rattus norvegicus 48-53 3900613-3 1985 Administration of the serotonin releaser dl-p-chloroamphetamine-HCl (PCA) to rats causes dose-dependent increases in renin secretion that can be blocked by serotonin depletion with p-chlorophenylalanine (PCPA), injections of 5,7-dihydroxytryptamine into the dorsal raphe nucleus or ablation of the mediobasal hypothalamus. dl-p-chloroamphetamine-hcl 41-67 renin Rattus norvegicus 117-122 3910916-4 1985 Both doses of cyclosporine resulted in stimulation of plasma renin activity (PRA) from control values of 5.6 +/- 0.8 ng/ml/hr to 11.6 +/- 2.0 with 10 mg/kg and 26.7 +/- 5.6 with 20 mg/kg. Cyclosporine 14-26 renin Rattus norvegicus 61-66 3900613-3 1985 Administration of the serotonin releaser dl-p-chloroamphetamine-HCl (PCA) to rats causes dose-dependent increases in renin secretion that can be blocked by serotonin depletion with p-chlorophenylalanine (PCPA), injections of 5,7-dihydroxytryptamine into the dorsal raphe nucleus or ablation of the mediobasal hypothalamus. Serotonin 22-31 renin Rattus norvegicus 117-122 3900613-3 1985 Administration of the serotonin releaser dl-p-chloroamphetamine-HCl (PCA) to rats causes dose-dependent increases in renin secretion that can be blocked by serotonin depletion with p-chlorophenylalanine (PCPA), injections of 5,7-dihydroxytryptamine into the dorsal raphe nucleus or ablation of the mediobasal hypothalamus. Fenclonine 181-202 renin Rattus norvegicus 117-122 3900613-3 1985 Administration of the serotonin releaser dl-p-chloroamphetamine-HCl (PCA) to rats causes dose-dependent increases in renin secretion that can be blocked by serotonin depletion with p-chlorophenylalanine (PCPA), injections of 5,7-dihydroxytryptamine into the dorsal raphe nucleus or ablation of the mediobasal hypothalamus. Fenclonine 204-208 renin Rattus norvegicus 117-122 3900613-3 1985 Administration of the serotonin releaser dl-p-chloroamphetamine-HCl (PCA) to rats causes dose-dependent increases in renin secretion that can be blocked by serotonin depletion with p-chlorophenylalanine (PCPA), injections of 5,7-dihydroxytryptamine into the dorsal raphe nucleus or ablation of the mediobasal hypothalamus. 5,7-Dihydroxytryptamine 225-248 renin Rattus norvegicus 117-122 3901779-2 1985 The purpose of this study was to determine whether increased renin release is related to impaired absorptive chloride transport in the loop of Henle. Chlorides 109-117 renin Rattus norvegicus 61-66 3901779-7 1985 Before saline infusion, plasma renin concentration (PRC) of Adx (350 +/- 108 U/ml) was greater (P less than 0.01) than that in controls (56 +/- 6) or Dex (108 +/- 36); sodium chloride infusion failed to inhibit PRC in Adx, whereas PRC was suppressed (P less than 0.01) by saline in Dex and controls. Adenylyl sulfate 60-63 renin Rattus norvegicus 31-36 3901779-8 1985 Thus stimulation of renin release in adrenalectomized animals was associated with decreased absorptive chloride transport in the loop of Henle. Chlorides 103-111 renin Rattus norvegicus 20-25 3901779-9 1985 Dexamethasone normalized loop function and renin responsiveness to sodium chloride. Sodium Chloride 67-82 renin Rattus norvegicus 43-48 3900340-7 1985 The hemodynamic responses to exogenous norepinephrine were affected by inhibition of the renin-angiotensin system with captopril and saralasin in a manner analogous to the neurally mediated responses. Norepinephrine 39-53 renin Rattus norvegicus 89-94 3900340-7 1985 The hemodynamic responses to exogenous norepinephrine were affected by inhibition of the renin-angiotensin system with captopril and saralasin in a manner analogous to the neurally mediated responses. Captopril 119-128 renin Rattus norvegicus 89-94 3162167-0 1985 Nitrendipine-induced stimulation of renin release by the isolated perfused rat kidney. Nitrendipine 0-12 renin Rattus norvegicus 36-41 3002926-0 1985 [Correlation between the inhibition of renin-angiotensin system and antihypertensive effect of MK-421 and captopril in 2-kidney, 1-clip renal hypertensive rats after single and repeated oral administration of MK-421 or captopril]. Enalapril 95-101 renin Rattus norvegicus 39-44 3002926-0 1985 [Correlation between the inhibition of renin-angiotensin system and antihypertensive effect of MK-421 and captopril in 2-kidney, 1-clip renal hypertensive rats after single and repeated oral administration of MK-421 or captopril]. Captopril 106-115 renin Rattus norvegicus 39-44 3002926-0 1985 [Correlation between the inhibition of renin-angiotensin system and antihypertensive effect of MK-421 and captopril in 2-kidney, 1-clip renal hypertensive rats after single and repeated oral administration of MK-421 or captopril]. Enalapril 209-215 renin Rattus norvegicus 39-44 3002926-0 1985 [Correlation between the inhibition of renin-angiotensin system and antihypertensive effect of MK-421 and captopril in 2-kidney, 1-clip renal hypertensive rats after single and repeated oral administration of MK-421 or captopril]. Captopril 219-228 renin Rattus norvegicus 39-44 3162167-1 1985 The direct effects of the organic calcium antagonist nitrendipine upon renin release were assessed using the isolated rat kidney perfused at constant pressure. Nitrendipine 53-65 renin Rattus norvegicus 71-76 3915608-2 1985 Effects of converting enzyme inhibitor (captopril) on the plasma and renal renin activity in two-kidney goldblatt hypertension in rats. Captopril 40-49 renin Rattus norvegicus 75-80 3162167-3 1985 Renin release as assessed by radioimmunoassay was stimulated 2.6-fold upon the administration of 10(-6) M nitrendipine. Nitrendipine 106-118 renin Rattus norvegicus 0-5 3162167-4 1985 Since this stimulation of renin release occurred in the absence of any alteration in perfusion pressure, we conclude that it represents a direct action of nitrendipine. Nitrendipine 155-167 renin Rattus norvegicus 26-31 2990872-5 1985 Renin release stimulated by 10(-7) M isoproterenol was inhibited by ANF with an ID50 of 5.8 x 10(-8) M. The renin-inhibitory effect was not calcium-dependent. Isoproterenol 37-50 renin Rattus norvegicus 0-5 2990872-5 1985 Renin release stimulated by 10(-7) M isoproterenol was inhibited by ANF with an ID50 of 5.8 x 10(-8) M. The renin-inhibitory effect was not calcium-dependent. Isoproterenol 37-50 renin Rattus norvegicus 108-113 3934013-2 1985 The well-known inhibition of renin release from granulated cells of the kidney is thought to be mediated by an increase in intracellular calcium. Calcium 137-144 renin Rattus norvegicus 29-34 3928488-1 1985 Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action. Z-Arg-Arg 72-81 renin Rattus norvegicus 14-19 3928488-1 1985 Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action. Z-Arg-Arg 72-81 renin Rattus norvegicus 123-128 3928488-1 1985 Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action. Pro-Phe-His 82-93 renin Rattus norvegicus 14-19 3928488-1 1985 Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action. Isoleucine 98-101 renin Rattus norvegicus 14-19 3928488-1 1985 Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action. Histidine 90-93 renin Rattus norvegicus 14-19 3928488-1 1985 Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action. Lysine 106-109 renin Rattus norvegicus 14-19 3928488-4 1985 In furosemide-treated marmosets, CGP 29 287 lowered blood pressure and inhibited plasma renin activity during intravenous infusion and after intravenous bolus injection. Furosemide 3-13 renin Rattus norvegicus 88-93 3861577-0 1985 Effects of prostaglandin synthesis inhibitors on the renin-angiotensin system and renal function. Prostaglandins 11-24 renin Rattus norvegicus 53-58 3861577-4 1985 Indomethacin decreased plasma active renin levels under all three experimental conditions. Indomethacin 0-12 renin Rattus norvegicus 37-42 3861577-10 1985 Indomethacin is the most potent inhibitor of active renin and, therefore, most likely to cause hyporeninemia. Indomethacin 0-12 renin Rattus norvegicus 52-57 3903651-0 1985 Effect of reduced chloride reabsorption on renin release in the isolated rat kidney. Chlorides 18-26 renin Rattus norvegicus 43-48 3912148-0 1985 [Effect of captopril on the renin activity in spontaneous hypertension in rats]. Captopril 11-20 renin Rattus norvegicus 28-33 3903651-1 1985 To investigate the relationship between tubular reabsorption of chloride and renal renin release in the isolated perfused rat kidney, perfusate renin activity was measured during substitution of either nitrate or thiocyanate for varying amounts of perfusate chloride but with maintained perfusate sodium concentration. Chlorides 64-72 renin Rattus norvegicus 83-88 3903651-2 1985 Renin rose significantly as perfusate chloride fell; there was a sevenfold increase between perfusion with normal chloride and almost complete substitution of chloride by nitrate. Chlorides 38-46 renin Rattus norvegicus 0-5 3903651-2 1985 Renin rose significantly as perfusate chloride fell; there was a sevenfold increase between perfusion with normal chloride and almost complete substitution of chloride by nitrate. Chlorides 114-122 renin Rattus norvegicus 0-5 3903651-2 1985 Renin rose significantly as perfusate chloride fell; there was a sevenfold increase between perfusion with normal chloride and almost complete substitution of chloride by nitrate. Chlorides 114-122 renin Rattus norvegicus 0-5 3903651-3 1985 With a normal perfusate chloride the addition of furosemide 10(-4) M to the perfusate also led to an increase in renin and a reduction in tubule chloride reabsorption. Furosemide 49-59 renin Rattus norvegicus 113-118 3903651-4 1985 For all these experiments there was a significant negative correlation between renin and absolute tubular reabsorption of chloride (r = -0.68, P less than 0.001), but no such relationship with absolute sodium reabsorption. Chlorides 122-130 renin Rattus norvegicus 79-84 3903651-8 1985 We conclude that renin release is influenced by a signal dependent on, and inversely proportional to, chloride reabsorption in the thick ascending limb of the Loop of Henle. Chlorides 102-110 renin Rattus norvegicus 17-22 3893987-0 1985 Role of extra- and intracellular calcium and calmodulin in renin release from rat kidney. Calcium 33-40 renin Rattus norvegicus 59-64 3893987-1 1985 Renin release from the juxtaglomerular cell appears to be inversely related to calcium concentration. Calcium 79-86 renin Rattus norvegicus 0-5 3893987-4 1985 Isoproterenol (10(-6) M) caused significant stimulation of renin release, whereas angiotensin (AII; 5 X 10(-5) M) suppressed basal as well as isoproterenol-stimulated renin release. Isoproterenol 0-13 renin Rattus norvegicus 59-64 3893987-4 1985 Isoproterenol (10(-6) M) caused significant stimulation of renin release, whereas angiotensin (AII; 5 X 10(-5) M) suppressed basal as well as isoproterenol-stimulated renin release. Isoproterenol 142-155 renin Rattus norvegicus 167-172 3893987-5 1985 Removal of calcium from the buffer reversed AII suppression of renin release. Calcium 11-18 renin Rattus norvegicus 63-68 3893987-6 1985 Nifedipine (10(-5) M), a specific calcium channel blocker, induced a marked increase in basal renin release. Nifedipine 0-10 renin Rattus norvegicus 94-99 3893987-7 1985 TMB-8, an inhibitor of intracellular calcium release, also caused a dose-related increase in basal renin release. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 0-5 renin Rattus norvegicus 99-104 3893987-7 1985 TMB-8, an inhibitor of intracellular calcium release, also caused a dose-related increase in basal renin release. Calcium 37-44 renin Rattus norvegicus 99-104 3893987-10 1985 Isoproterenol further stimulated renin release in the presence of trifluoperazine and calmidazolium. Isoproterenol 0-13 renin Rattus norvegicus 33-38 3893987-10 1985 Isoproterenol further stimulated renin release in the presence of trifluoperazine and calmidazolium. Trifluoperazine 66-81 renin Rattus norvegicus 33-38 3893987-10 1985 Isoproterenol further stimulated renin release in the presence of trifluoperazine and calmidazolium. calmidazolium 86-99 renin Rattus norvegicus 33-38 2999488-11 1985 Enalapril and captopril slightly increased plasma renin concentration. Enalapril 0-9 renin Rattus norvegicus 50-55 3161339-0 1985 Effect of 6-aminonicotinamide on renin release in isolated rat kidney: possible role for the pentose pathway. 6-Aminonicotinamide 10-29 renin Rattus norvegicus 33-38 3897519-1 1985 Captopril caused a renin-dependent increase in water intake in rats with bilateral ureteric ligation. Captopril 0-9 renin Rattus norvegicus 19-24 3897519-1 1985 Captopril caused a renin-dependent increase in water intake in rats with bilateral ureteric ligation. Water 47-52 renin Rattus norvegicus 19-24 3897519-7 1985 Low and high dosage of captopril caused increases in plasma renin concentration in adrenalectomized rats, but in contrast renin remained undetectable in the plasma of deoxycorticosterone-treated rats after the highest dosage of captopril. Captopril 23-32 renin Rattus norvegicus 60-65 3161339-5 1985 In the presence of 5 mM lactate, the renin release of eight nonfiltering kidneys was 0.31 +/- 0.06 ng ANG I X min-1 X ml-1. Lactic Acid 24-31 renin Rattus norvegicus 37-42 3161339-7 1985 6-Aminonicotinamide also completely blocked furosemide-stimulated renin release without having any effect on glomerular filtration rate or furosemide-induced natriuresis. 6-Aminonicotinamide 0-19 renin Rattus norvegicus 66-71 3161339-7 1985 6-Aminonicotinamide also completely blocked furosemide-stimulated renin release without having any effect on glomerular filtration rate or furosemide-induced natriuresis. Furosemide 44-54 renin Rattus norvegicus 66-71 3161339-9 1985 We conclude that 6-aminonicotinamide interferes with renin release by nonfiltering kidneys and also inhibits furosemide-stimulated renin release but does not affect beta-adrenergic-stimulated renin secretion. 6-Aminonicotinamide 17-36 renin Rattus norvegicus 53-58 3161339-9 1985 We conclude that 6-aminonicotinamide interferes with renin release by nonfiltering kidneys and also inhibits furosemide-stimulated renin release but does not affect beta-adrenergic-stimulated renin secretion. 6-Aminonicotinamide 17-36 renin Rattus norvegicus 131-136 3161339-9 1985 We conclude that 6-aminonicotinamide interferes with renin release by nonfiltering kidneys and also inhibits furosemide-stimulated renin release but does not affect beta-adrenergic-stimulated renin secretion. 6-Aminonicotinamide 17-36 renin Rattus norvegicus 131-136 3161339-9 1985 We conclude that 6-aminonicotinamide interferes with renin release by nonfiltering kidneys and also inhibits furosemide-stimulated renin release but does not affect beta-adrenergic-stimulated renin secretion. Furosemide 109-119 renin Rattus norvegicus 131-136 3161339-9 1985 We conclude that 6-aminonicotinamide interferes with renin release by nonfiltering kidneys and also inhibits furosemide-stimulated renin release but does not affect beta-adrenergic-stimulated renin secretion. Furosemide 109-119 renin Rattus norvegicus 131-136 3161339-10 1985 Glucose but not lactate is important for maintaining augmented rates of renin secretion in nonfiltering kidneys. Glucose 0-7 renin Rattus norvegicus 72-77 3161339-11 1985 6-Aminonicotinamide significantly reduced renal renin content in the presence of glucose. 6-Aminonicotinamide 0-19 renin Rattus norvegicus 48-53 2999488-11 1985 Enalapril and captopril slightly increased plasma renin concentration. Captopril 14-23 renin Rattus norvegicus 50-55 3903298-3 1985 Nipradilol decreased plasma renin concentration in acute and subacute studies, whereas it was unchanged with prizidilol treatment. nipradilol 0-10 renin Rattus norvegicus 28-33 3893163-0 1985 Renin release in turtles: effects of volume depletion and furosemide administration. Furosemide 58-68 renin Rattus norvegicus 0-5 3893163-6 1985 In other studies 48 h of furosemide administration in awake turtles increased renin more than threefold (P less than 0.05) and were accompanied by concomitant reductions in plasma sodium and potassium (P less than 0.05). Furosemide 25-35 renin Rattus norvegicus 78-83 3891614-1 1985 Renin-prostaglandin interaction. Prostaglandins 6-19 renin Rattus norvegicus 0-5 3891614-6 1985 Isoproterenol and prostaglandin E2 stimulated renin release in controls, while diabetic rats responded only to isoproterenol. Isoproterenol 0-13 renin Rattus norvegicus 46-51 3891614-6 1985 Isoproterenol and prostaglandin E2 stimulated renin release in controls, while diabetic rats responded only to isoproterenol. Dinoprostone 18-34 renin Rattus norvegicus 46-51 3891614-8 1985 An additive effect of a maximum dose of isoproterenol (10(-5) M) and prostaglandin E2 (10(-4) M) on renin release was observed in nondiabetic controls and in diabetic rats treated with insulin pump, but not in untreated diabetic rats. Isoproterenol 40-53 renin Rattus norvegicus 100-105 3891614-8 1985 An additive effect of a maximum dose of isoproterenol (10(-5) M) and prostaglandin E2 (10(-4) M) on renin release was observed in nondiabetic controls and in diabetic rats treated with insulin pump, but not in untreated diabetic rats. Dinoprostone 69-85 renin Rattus norvegicus 100-105 3906080-1 1985 This study was carried out to investigate the effect of tinoridine (2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c] pyridine), a non-steroidal anti-inflammatory drug, on the lipid peroxidation and renin release in the renin granule fraction. tinoridine 56-66 renin Rattus norvegicus 215-220 3906080-1 1985 This study was carried out to investigate the effect of tinoridine (2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c] pyridine), a non-steroidal anti-inflammatory drug, on the lipid peroxidation and renin release in the renin granule fraction. tinoridine 56-66 renin Rattus norvegicus 236-241 3906080-1 1985 This study was carried out to investigate the effect of tinoridine (2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c] pyridine), a non-steroidal anti-inflammatory drug, on the lipid peroxidation and renin release in the renin granule fraction. tinoridine 68-142 renin Rattus norvegicus 215-220 3906080-1 1985 This study was carried out to investigate the effect of tinoridine (2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c] pyridine), a non-steroidal anti-inflammatory drug, on the lipid peroxidation and renin release in the renin granule fraction. tinoridine 68-142 renin Rattus norvegicus 236-241 3906080-2 1985 The renin granule fraction was prepared from the kidney cortex homogenate by a discontinuous sucrose density gradient centrifugation. Sucrose 93-100 renin Rattus norvegicus 4-9 3906080-4 1985 When the renin granule fraction was incubated with 50 microM tinoridine at 37 degrees C, lipid peroxide formation in this fraction was completely inhibited. tinoridine 61-71 renin Rattus norvegicus 9-14 3906080-4 1985 When the renin granule fraction was incubated with 50 microM tinoridine at 37 degrees C, lipid peroxide formation in this fraction was completely inhibited. Lipid Peroxides 89-103 renin Rattus norvegicus 9-14 3906080-6 1985 Tinoridine, at concentrations from 5 microM up to 100 microM, produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 microM ascorbic acid in the renin granule fraction. tinoridine 0-10 renin Rattus norvegicus 170-175 3906080-6 1985 Tinoridine, at concentrations from 5 microM up to 100 microM, produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 microM ascorbic acid in the renin granule fraction. tinoridine 0-10 renin Rattus norvegicus 226-231 3906080-6 1985 Tinoridine, at concentrations from 5 microM up to 100 microM, produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 microM ascorbic acid in the renin granule fraction. Lipid Peroxides 141-155 renin Rattus norvegicus 226-231 3906080-6 1985 Tinoridine, at concentrations from 5 microM up to 100 microM, produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 microM ascorbic acid in the renin granule fraction. Ascorbic Acid 205-218 renin Rattus norvegicus 170-175 3906080-6 1985 Tinoridine, at concentrations from 5 microM up to 100 microM, produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 microM ascorbic acid in the renin granule fraction. Ascorbic Acid 205-218 renin Rattus norvegicus 226-231 3906080-8 1985 These results suggest that tinoridine suppresses renin release by inhibiting the oxidative disintegration of membranes of renin granules. tinoridine 27-37 renin Rattus norvegicus 49-54 3906080-8 1985 These results suggest that tinoridine suppresses renin release by inhibiting the oxidative disintegration of membranes of renin granules. tinoridine 27-37 renin Rattus norvegicus 122-127 3901121-0 1985 Effect of indomethacin on the adrenal renin response to nephrectomy in the rat. Indomethacin 10-22 renin Rattus norvegicus 38-43 3901121-1 1985 The role of prostaglandins in the control of adrenal renin in vivo was evaluated in nephrectomized rats. Prostaglandins 12-26 renin Rattus norvegicus 53-58 3901121-3 1985 Indomethacin treatment significantly suppressed the adrenal renin response to nephrectomy. Indomethacin 0-12 renin Rattus norvegicus 60-65 3901121-8 1985 These data indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the adrenal renin response to nephrectomy, suggesting that prostaglandins may play a role in the adrenal response to nephrectomy. Prostaglandins 39-52 renin Rattus norvegicus 108-113 3901121-8 1985 These data indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the adrenal renin response to nephrectomy, suggesting that prostaglandins may play a role in the adrenal response to nephrectomy. Indomethacin 66-78 renin Rattus norvegicus 108-113 3901121-8 1985 These data indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the adrenal renin response to nephrectomy, suggesting that prostaglandins may play a role in the adrenal response to nephrectomy. Prostaglandins 155-169 renin Rattus norvegicus 108-113 2409429-1 1985 This study examined the role of cGMP in the control of renin release from isolated rat glomeruli. Cyclic GMP 32-36 renin Rattus norvegicus 55-60 2409429-2 1985 An inverse correlation between renin release and cGMP content of isolated glomeruli was found under several conditions of incubation. Cyclic GMP 49-53 renin Rattus norvegicus 31-36 2409429-4 1985 These same incubation conditions enhance the release of renin induced by isoproterenol (DBcAMP) in isolated glomeruli. Isoproterenol 73-86 renin Rattus norvegicus 56-61 2409429-4 1985 These same incubation conditions enhance the release of renin induced by isoproterenol (DBcAMP) in isolated glomeruli. Bucladesine 88-94 renin Rattus norvegicus 56-61 3931111-3 1985 The intracerebral administration of renin and angiotensin II increases the latency time to thermoalgesic stimuli which is reduced, as in the immobilisation stress, by naloxone and saralasin. Naloxone 167-175 renin Rattus norvegicus 36-41 3898016-0 1985 Effects of adenosine on renin release from isolated rat glomeruli and kidney slices. Adenosine 11-20 renin Rattus norvegicus 24-29 3931111-3 1985 The intracerebral administration of renin and angiotensin II increases the latency time to thermoalgesic stimuli which is reduced, as in the immobilisation stress, by naloxone and saralasin. Saralasin 180-189 renin Rattus norvegicus 36-41 3898016-1 1985 Adenosine produced by the macula densa cells in response to changes in the tubular NaCl-concentration has been suggested to inhibit renin release in vivo. Adenosine 0-9 renin Rattus norvegicus 132-137 3898016-1 1985 Adenosine produced by the macula densa cells in response to changes in the tubular NaCl-concentration has been suggested to inhibit renin release in vivo. Sodium Chloride 83-88 renin Rattus norvegicus 132-137 2989497-5 1985 Calcium antagonists, verapamil and nifedipine, attenuated the responses of renin release to NE, ME and PE, in a concentration-dependent manner. Calcium 0-7 renin Rattus norvegicus 75-80 3898016-5 1985 Adenosine (10 micrograms/ml) halved basal renin release from incubated KS as compared to controls (P less than 0.001, n = 8, 8). Adenosine 0-9 renin Rattus norvegicus 42-47 3898016-5 1985 Adenosine (10 micrograms/ml) halved basal renin release from incubated KS as compared to controls (P less than 0.001, n = 8, 8). ks 71-73 renin Rattus norvegicus 42-47 3898016-6 1985 Renin release from LAG stimulated by calcium depletion was also inhibited (P less than 0.05, n = 8, 9) whereas basal release was not affected (n = 6, 12). Calcium 37-44 renin Rattus norvegicus 0-5 3898016-7 1985 No effect was detected neither on basal nor on calcium stimulated renin release from SAG. Calcium 47-54 renin Rattus norvegicus 66-71 3898016-8 1985 We conclude that adenosine inhibits renin release in vitro by a mechanism independent of a functioning nephron, and which involves only the JG-cells located in the afferent arteriole at some distance from the glomerulus. Adenosine 17-26 renin Rattus norvegicus 36-41 2989497-0 1985 Inhibitory effects of norepinephrine, methoxamine and phenylephrine on renin release from rat kidney cortical slices. Norepinephrine 22-36 renin Rattus norvegicus 71-76 2989497-5 1985 Calcium antagonists, verapamil and nifedipine, attenuated the responses of renin release to NE, ME and PE, in a concentration-dependent manner. Verapamil 21-30 renin Rattus norvegicus 75-80 2989497-0 1985 Inhibitory effects of norepinephrine, methoxamine and phenylephrine on renin release from rat kidney cortical slices. Methoxamine 38-49 renin Rattus norvegicus 71-76 2989497-0 1985 Inhibitory effects of norepinephrine, methoxamine and phenylephrine on renin release from rat kidney cortical slices. Phenylephrine 54-67 renin Rattus norvegicus 71-76 2989497-5 1985 Calcium antagonists, verapamil and nifedipine, attenuated the responses of renin release to NE, ME and PE, in a concentration-dependent manner. Nifedipine 35-45 renin Rattus norvegicus 75-80 2989497-2 1985 Norepinephrine (NE), methoxamine (ME) and phenylephrine (PE) produced a concentration-dependent inhibition of renin release from rat kidney cortical slices, whereas clonidine was without effect. Norepinephrine 0-14 renin Rattus norvegicus 110-115 2989497-2 1985 Norepinephrine (NE), methoxamine (ME) and phenylephrine (PE) produced a concentration-dependent inhibition of renin release from rat kidney cortical slices, whereas clonidine was without effect. Methoxamine 21-32 renin Rattus norvegicus 110-115 2989497-2 1985 Norepinephrine (NE), methoxamine (ME) and phenylephrine (PE) produced a concentration-dependent inhibition of renin release from rat kidney cortical slices, whereas clonidine was without effect. Methoxamine 34-36 renin Rattus norvegicus 110-115 2989497-2 1985 Norepinephrine (NE), methoxamine (ME) and phenylephrine (PE) produced a concentration-dependent inhibition of renin release from rat kidney cortical slices, whereas clonidine was without effect. Phenylephrine 42-55 renin Rattus norvegicus 110-115 2989497-2 1985 Norepinephrine (NE), methoxamine (ME) and phenylephrine (PE) produced a concentration-dependent inhibition of renin release from rat kidney cortical slices, whereas clonidine was without effect. Phenylephrine 57-59 renin Rattus norvegicus 110-115 2989497-5 1985 Calcium antagonists, verapamil and nifedipine, attenuated the responses of renin release to NE, ME and PE, in a concentration-dependent manner. Methoxamine 96-98 renin Rattus norvegicus 75-80 2989497-3 1985 NE-, ME- and PE-induced inhibition of renin release was blocked by prazosin, which was 2 or 3 orders of magnitude more potent than yohimbine. Methoxamine 5-7 renin Rattus norvegicus 38-43 2989497-3 1985 NE-, ME- and PE-induced inhibition of renin release was blocked by prazosin, which was 2 or 3 orders of magnitude more potent than yohimbine. Phenylephrine 13-15 renin Rattus norvegicus 38-43 2989497-5 1985 Calcium antagonists, verapamil and nifedipine, attenuated the responses of renin release to NE, ME and PE, in a concentration-dependent manner. Phenylephrine 103-105 renin Rattus norvegicus 75-80 2989497-3 1985 NE-, ME- and PE-induced inhibition of renin release was blocked by prazosin, which was 2 or 3 orders of magnitude more potent than yohimbine. Prazosin 67-75 renin Rattus norvegicus 38-43 2989497-4 1985 The inhibitory effects of NE, ME and PE on renin release from the slices were abolished by removal of calcium from the incubation medium. Methoxamine 30-32 renin Rattus norvegicus 43-48 2989497-4 1985 The inhibitory effects of NE, ME and PE on renin release from the slices were abolished by removal of calcium from the incubation medium. Phenylephrine 37-39 renin Rattus norvegicus 43-48 2989497-6 1985 The inhibitory effects of NE, ME and PE on renin release were blocked significantly by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, but not by N-(6-aminohexyl)-1-naphthalenesulfonamide, which has virtually no calmodulin antagonistic activity. Methoxamine 30-32 renin Rattus norvegicus 43-48 2989497-4 1985 The inhibitory effects of NE, ME and PE on renin release from the slices were abolished by removal of calcium from the incubation medium. Calcium 102-109 renin Rattus norvegicus 43-48 2989497-6 1985 The inhibitory effects of NE, ME and PE on renin release were blocked significantly by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, but not by N-(6-aminohexyl)-1-naphthalenesulfonamide, which has virtually no calmodulin antagonistic activity. Phenylephrine 37-39 renin Rattus norvegicus 43-48 2989497-6 1985 The inhibitory effects of NE, ME and PE on renin release were blocked significantly by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, but not by N-(6-aminohexyl)-1-naphthalenesulfonamide, which has virtually no calmodulin antagonistic activity. W 7 87-137 renin Rattus norvegicus 43-48 2989497-7 1985 These findings suggest that alpha adrenoceptor agonists inhibit renin release from rat kidney cortical slices mainly via alpha-1 adrenoceptors and that calcium influx followed by the activation of the calcium-calmodulin system is involved in the above inhibition. Calcium 152-159 renin Rattus norvegicus 64-69 3160963-0 1985 Serotonin and norepinephrine-dependent effects of fenfluramine on plasma renin activity in conscious male rats. Serotonin 0-9 renin Rattus norvegicus 73-78 3160963-0 1985 Serotonin and norepinephrine-dependent effects of fenfluramine on plasma renin activity in conscious male rats. Norepinephrine 14-28 renin Rattus norvegicus 73-78 3160963-0 1985 Serotonin and norepinephrine-dependent effects of fenfluramine on plasma renin activity in conscious male rats. Fenfluramine 50-62 renin Rattus norvegicus 73-78 3160963-1 1985 Administration of DL-fenfluramine to male rats caused an initial rise, followed by a sustained decrease in plasma renin activity. Fenfluramine 18-33 renin Rattus norvegicus 114-119 3160963-3 1985 Pretreatment with either of the blockers of serotonin uptake, fluoxetine or indalpine blocked the increase in plasma renin activity induced by fenfluramine at 30 min, but did not affect the decrease at 4 hr after injection. Serotonin 44-53 renin Rattus norvegicus 117-122 3160963-3 1985 Pretreatment with either of the blockers of serotonin uptake, fluoxetine or indalpine blocked the increase in plasma renin activity induced by fenfluramine at 30 min, but did not affect the decrease at 4 hr after injection. Fluoxetine 62-72 renin Rattus norvegicus 117-122 3160963-3 1985 Pretreatment with either of the blockers of serotonin uptake, fluoxetine or indalpine blocked the increase in plasma renin activity induced by fenfluramine at 30 min, but did not affect the decrease at 4 hr after injection. indalpine 76-85 renin Rattus norvegicus 117-122 3160963-3 1985 Pretreatment with either of the blockers of serotonin uptake, fluoxetine or indalpine blocked the increase in plasma renin activity induced by fenfluramine at 30 min, but did not affect the decrease at 4 hr after injection. Fenfluramine 143-155 renin Rattus norvegicus 117-122 3160963-4 1985 Similarly, pretreatment with the inhibitor of the synthesis of serotonin, p-chlorophenylalanine methylester (PCPA) blocked the initial (30 min) but not the delayed (4 hr) effect of fenfluramine on plasma renin activity. Serotonin 63-72 renin Rattus norvegicus 204-209 3160963-4 1985 Similarly, pretreatment with the inhibitor of the synthesis of serotonin, p-chlorophenylalanine methylester (PCPA) blocked the initial (30 min) but not the delayed (4 hr) effect of fenfluramine on plasma renin activity. 4-chlorophenylalanine methyl ester 74-107 renin Rattus norvegicus 204-209 3160963-4 1985 Similarly, pretreatment with the inhibitor of the synthesis of serotonin, p-chlorophenylalanine methylester (PCPA) blocked the initial (30 min) but not the delayed (4 hr) effect of fenfluramine on plasma renin activity. 4-chlorophenylalanine methyl ester 109-113 renin Rattus norvegicus 204-209 3160963-4 1985 Similarly, pretreatment with the inhibitor of the synthesis of serotonin, p-chlorophenylalanine methylester (PCPA) blocked the initial (30 min) but not the delayed (4 hr) effect of fenfluramine on plasma renin activity. Fenfluramine 181-193 renin Rattus norvegicus 204-209 3160963-7 1985 Pretreatment with the blocker of the uptake of norepinephrine, desipramine did not prevent the initial (30 min) effect but completely prevented the delayed (4 hr) effect of fenfluramine on plasma renin activity. Norepinephrine 47-61 renin Rattus norvegicus 196-201 3160963-7 1985 Pretreatment with the blocker of the uptake of norepinephrine, desipramine did not prevent the initial (30 min) effect but completely prevented the delayed (4 hr) effect of fenfluramine on plasma renin activity. Desipramine 63-74 renin Rattus norvegicus 196-201 3160963-7 1985 Pretreatment with the blocker of the uptake of norepinephrine, desipramine did not prevent the initial (30 min) effect but completely prevented the delayed (4 hr) effect of fenfluramine on plasma renin activity. Fenfluramine 173-185 renin Rattus norvegicus 196-201 3894036-3 1985 Propranolol partially blocked the increase in plasma renin concentration produced by anesthetics. Propranolol 0-11 renin Rattus norvegicus 53-58 2862302-7 1985 Repeated oral administrations of amosulalol and labetalol (50 mg/kg/day, b.i.d., for 12 weeks) produced not only an antihypertensive effect without evidence of tolerance, but also reductions in plasma renin activity (PRA) and heart rate in SHR with established hypertension. amosulalol 33-43 renin Rattus norvegicus 201-206 2986784-6 1985 Affinity chromatography of an organelle-enriched brain fraction was carried out using a caseinyl-sepharose column and resulted in the separation of renin from cathepsin D activity; the renin peak was inhibited by antibodies raised against rat kidney renin. Sepharose 97-106 renin Rattus norvegicus 148-153 2986784-6 1985 Affinity chromatography of an organelle-enriched brain fraction was carried out using a caseinyl-sepharose column and resulted in the separation of renin from cathepsin D activity; the renin peak was inhibited by antibodies raised against rat kidney renin. Sepharose 97-106 renin Rattus norvegicus 185-190 2986784-6 1985 Affinity chromatography of an organelle-enriched brain fraction was carried out using a caseinyl-sepharose column and resulted in the separation of renin from cathepsin D activity; the renin peak was inhibited by antibodies raised against rat kidney renin. Sepharose 97-106 renin Rattus norvegicus 185-190 3922379-3 1985 TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 148-153 renin Rattus norvegicus 32-37 3922379-3 1985 TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 148-153 renin Rattus norvegicus 181-186 3922379-3 1985 TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187. Potassium Chloride 231-234 renin Rattus norvegicus 32-37 3922379-3 1985 TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187. Calcimycin 239-245 renin Rattus norvegicus 32-37 3884235-5 1985 Plasma renin activity rose slightly in nifedipine treated SB and SBN rats, but decreased significantly in treated SBH rats. Nifedipine 39-49 renin Rattus norvegicus 7-12 3884235-5 1985 Plasma renin activity rose slightly in nifedipine treated SB and SBN rats, but decreased significantly in treated SBH rats. Antimony 65-68 renin Rattus norvegicus 7-12 2485266-15 1985 However, in the former condition, Brattleboro rats showed a profound and progressive hypotension in response to captopril, indicating an indispensable role for the renin-angiotensin system in the maintenance of blood pressure in these animals during water deprivation. Captopril 112-121 renin Rattus norvegicus 164-169 3922379-0 1985 Stimulation of renin secretion by 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8). 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 34-84 renin Rattus norvegicus 15-20 3922379-0 1985 Stimulation of renin secretion by 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8). 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 86-91 renin Rattus norvegicus 15-20 3922379-3 1985 TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 0-5 renin Rattus norvegicus 32-37 3922379-3 1985 TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 0-5 renin Rattus norvegicus 181-186 2862302-7 1985 Repeated oral administrations of amosulalol and labetalol (50 mg/kg/day, b.i.d., for 12 weeks) produced not only an antihypertensive effect without evidence of tolerance, but also reductions in plasma renin activity (PRA) and heart rate in SHR with established hypertension. Labetalol 48-57 renin Rattus norvegicus 201-206 3883811-0 1985 Role of prostaglandins in renin suppression during acute potassium loading. Prostaglandins 8-22 renin Rattus norvegicus 26-31 2992141-0 1985 [Changes in the activity of enzymes of renin-angiotensin and kinin systems in the rat brain after adrenalectomy and administration of hydrocortisone]. Hydrocortisone 134-148 renin Rattus norvegicus 39-44 2992141-3 1985 After hydrocortisone administration to adrenalectomized rats the angiotensin-converting enzyme activity of the hippocamp and pituitary is shown to be normalized as well as renin-like enzyme and kininase I of the hippocamp and corpus striatum. Hydrocortisone 6-20 renin Rattus norvegicus 172-177 2858796-0 1985 The non-benzodiazepine anxiolytic buspirone inhibits stress-induced renin secretion and lowers heart rate. Buspirone 34-43 renin Rattus norvegicus 68-73 2858796-1 1985 The non benzodiazepine drug, buspirone, produces a dose-dependent biphasic effect on plasma renin activity in non-stressed rats. Buspirone 29-38 renin Rattus norvegicus 92-97 2858796-5 1985 The maximal decrease in plasma renin activity produced by buspirone (1.0 mg/kg i.p.) Buspirone 58-67 renin Rattus norvegicus 31-36 2985064-0 1985 Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. Platelet Activating Factor 61-99 renin Rattus norvegicus 14-19 2985064-1 1985 Acetylglyceryl ether phosphorylcholine (AGEPC), commonly known as platelet activating factor, was found to strongly inhibit renin secretion in cultures rich in juxtaglomerular cells. Platelet Activating Factor 0-38 renin Rattus norvegicus 124-129 2985064-1 1985 Acetylglyceryl ether phosphorylcholine (AGEPC), commonly known as platelet activating factor, was found to strongly inhibit renin secretion in cultures rich in juxtaglomerular cells. Platelet Activating Factor 40-45 renin Rattus norvegicus 124-129 2985064-3 1985 Simultaneous addition of the calcium channel blocker verapamil abolished the effects of AGEPC on both renin secretion and calcium permeability. Verapamil 53-62 renin Rattus norvegicus 102-107 2985064-3 1985 Simultaneous addition of the calcium channel blocker verapamil abolished the effects of AGEPC on both renin secretion and calcium permeability. Calcium 29-36 renin Rattus norvegicus 102-107 3883812-3 1985 Relative to control data in rats fed a 0.162 mmol/g potassium diet, the urinary excretion of 6-keto-PGF1 alpha was not affected by high potassium intake but increased (P less than 0.05) by 25% in rats fed a low potassium diet for 13 days and was associated with reduction of plasma potassium and with elevation of both plasma renin and net release of 6-keto-PGF1 alpha from renal inner medulla slices incubated in Krebs solution. 6-keto-pgf1 93-104 renin Rattus norvegicus 326-331 3884503-5 1985 Verapamil markedly accelerated heart rate and stimulated renin release in all rats. Verapamil 0-9 renin Rattus norvegicus 57-62 3893434-1 1985 Rat urinary renin was purified by a procedure involving ammonium sulfate fractionation, pepstatin-aminohexyl-Sepharose 4B chromatography, ion exchange chromatography and gel filtration. Ammonium Sulfate 56-72 renin Rattus norvegicus 12-17 3884504-10 1985 Electrophoresis of partially purified inactive renin in sodium dodecyl sulfate (SDS) polyacrylamide gel followed by transblotting of proteins to a nitrocellulose sheet and immunochemical staining with anti-renin IgG showed a single protein band with a molecular weight of 48,000. Sodium Dodecyl Sulfate 56-78 renin Rattus norvegicus 47-52 3884504-10 1985 Electrophoresis of partially purified inactive renin in sodium dodecyl sulfate (SDS) polyacrylamide gel followed by transblotting of proteins to a nitrocellulose sheet and immunochemical staining with anti-renin IgG showed a single protein band with a molecular weight of 48,000. Sodium Dodecyl Sulfate 80-83 renin Rattus norvegicus 47-52 3884504-10 1985 Electrophoresis of partially purified inactive renin in sodium dodecyl sulfate (SDS) polyacrylamide gel followed by transblotting of proteins to a nitrocellulose sheet and immunochemical staining with anti-renin IgG showed a single protein band with a molecular weight of 48,000. polyacrylamide gels 85-103 renin Rattus norvegicus 47-52 3884504-11 1985 Activation of inactive renin by trypsin was accompanied by the reduction of the 48,000-dalton native protein to a 39,000-dalton protein as determined by the SDS polyacrylamide gel electrophoresis and the transblotting. Sodium Dodecyl Sulfate 157-160 renin Rattus norvegicus 23-28 3884504-11 1985 Activation of inactive renin by trypsin was accompanied by the reduction of the 48,000-dalton native protein to a 39,000-dalton protein as determined by the SDS polyacrylamide gel electrophoresis and the transblotting. polyacrylamide 161-175 renin Rattus norvegicus 23-28 2988086-7 1985 These in vitro data in the SD rat suggest that: 1) stimulation of renin release by DOP is time-dependent and is mediated by a TcAMP-generating mechanism, and 2) the increase in renin release by PIM administration appears to involve pharmacological inactivation of TcAMP-generating pathways and disruption of membrane permeability, leading to uncontrolled RR. Dopamine 83-86 renin Rattus norvegicus 66-71 2983063-8 1985 Ouabain, vanadate and K-depolarization, all of which are believed to increase intracellular calcium, antagonized CHA- and NECA-stimulated renin secretion, suggesting that the stimulatory effect of these agonists is mediated by decreased intracellular calcium. Vanadates 9-17 renin Rattus norvegicus 138-143 2983063-8 1985 Ouabain, vanadate and K-depolarization, all of which are believed to increase intracellular calcium, antagonized CHA- and NECA-stimulated renin secretion, suggesting that the stimulatory effect of these agonists is mediated by decreased intracellular calcium. Calcium 92-99 renin Rattus norvegicus 138-143 2983063-8 1985 Ouabain, vanadate and K-depolarization, all of which are believed to increase intracellular calcium, antagonized CHA- and NECA-stimulated renin secretion, suggesting that the stimulatory effect of these agonists is mediated by decreased intracellular calcium. N(6)-cyclohexyladenosine 113-116 renin Rattus norvegicus 138-143 2983063-1 1985 Previous studies by others have demonstrated that exogenous adenosine inhibits renin secretion in vivo. Adenosine 60-69 renin Rattus norvegicus 79-84 2988086-7 1985 These in vitro data in the SD rat suggest that: 1) stimulation of renin release by DOP is time-dependent and is mediated by a TcAMP-generating mechanism, and 2) the increase in renin release by PIM administration appears to involve pharmacological inactivation of TcAMP-generating pathways and disruption of membrane permeability, leading to uncontrolled RR. Dopamine 83-86 renin Rattus norvegicus 177-182 2988086-7 1985 These in vitro data in the SD rat suggest that: 1) stimulation of renin release by DOP is time-dependent and is mediated by a TcAMP-generating mechanism, and 2) the increase in renin release by PIM administration appears to involve pharmacological inactivation of TcAMP-generating pathways and disruption of membrane permeability, leading to uncontrolled RR. tcamp 126-131 renin Rattus norvegicus 66-71 4063547-3 1985 The overactivity of the renin-angiotensin system in sodium-depleted rats was demonstrated by the fall in mean arterial pressure (15 +/- 2 vs 0.5 +/- 1 mmHg in sodium-depleted and control rats, respectively), after blocking the converting enzyme with BPP9a (SQ 20881) and also by evaluating plasma renin activity (10 +/- 8 vs 3.0 +/- 0.6 ng AI ml-1 h-1 in sodium-depleted and control rats, respectively). Sodium 159-165 renin Rattus norvegicus 24-29 2861268-11 1985 N-696 treatments showed a tendency to decrease plasma renin concentration (PRC) in SHR and DOC rats, whereas PPL treatments significantly decreased PRC in these hypertensive rats. Nitrogen 0-1 renin Rattus norvegicus 54-59 3881982-0 1985 Role of renin-angiotensin-aldosterone system in NaCl appetite of rats. Sodium Chloride 48-52 renin Rattus norvegicus 8-13 3881982-4 1985 An additional point is the fact that each paradigm inducing a salt appetite, except salivariectomy, can be linked to an effect on the renin-angiotensin-aldosterone system. Salts 62-66 renin Rattus norvegicus 134-139 3000390-1 1985 Antihypertensive activity of alacepril (1-[(S)-3-acetylthio-2-methylpropanoyl]-L-prolyl-L-phenylalanine, DU-1219), an orally active angiotensin converting enzyme (ACE) inhibitor, was investigated in hypertensive models with normal or low plasma renin activity (PRA). alacepril 29-38 renin Rattus norvegicus 245-250 2981387-1 1985 Previous results have demonstrated that two inhibitors of Na-and-K-activated adenosine triphosphatase (ouabain, vanadate) lead to stimulated prostaglandin E2 release and to inhibited renin secretion in the rat renal cortical slice preparation. Vanadates 112-120 renin Rattus norvegicus 183-188 4063547-3 1985 The overactivity of the renin-angiotensin system in sodium-depleted rats was demonstrated by the fall in mean arterial pressure (15 +/- 2 vs 0.5 +/- 1 mmHg in sodium-depleted and control rats, respectively), after blocking the converting enzyme with BPP9a (SQ 20881) and also by evaluating plasma renin activity (10 +/- 8 vs 3.0 +/- 0.6 ng AI ml-1 h-1 in sodium-depleted and control rats, respectively). Sodium 52-58 renin Rattus norvegicus 24-29 2579903-7 1985 The basal level of renin measured when the glomeruli were superfused with BSA-Krebs was two to three times greater than when they were superfused with Krebs alone (p less than 0.001). krebs 78-83 renin Rattus norvegicus 19-24 4063547-3 1985 The overactivity of the renin-angiotensin system in sodium-depleted rats was demonstrated by the fall in mean arterial pressure (15 +/- 2 vs 0.5 +/- 1 mmHg in sodium-depleted and control rats, respectively), after blocking the converting enzyme with BPP9a (SQ 20881) and also by evaluating plasma renin activity (10 +/- 8 vs 3.0 +/- 0.6 ng AI ml-1 h-1 in sodium-depleted and control rats, respectively). Sodium 52-58 renin Rattus norvegicus 297-302 4063547-3 1985 The overactivity of the renin-angiotensin system in sodium-depleted rats was demonstrated by the fall in mean arterial pressure (15 +/- 2 vs 0.5 +/- 1 mmHg in sodium-depleted and control rats, respectively), after blocking the converting enzyme with BPP9a (SQ 20881) and also by evaluating plasma renin activity (10 +/- 8 vs 3.0 +/- 0.6 ng AI ml-1 h-1 in sodium-depleted and control rats, respectively). Sodium 159-165 renin Rattus norvegicus 24-29 3910304-1 1985 The role of circulating epinephrine in the regulation of renin release was studied in unanesthetized rats with glucocorticoid-induced hypertension. Epinephrine 24-35 renin Rattus norvegicus 57-62 3910304-5 1985 In both adrenalectomized and sham-operated rats plasma renin activity was determined after a 30 min infusion of the beta-adrenoceptor stimulant isoproterenol (40 ng/min) or its vehicle. Isoproterenol 144-157 renin Rattus norvegicus 55-60 3910304-7 1985 Plasma renin activity was significantly higher in epinephrine-deficient than in sham-operated rats. Epinephrine 50-61 renin Rattus norvegicus 7-12 3910304-8 1985 Renin secretion was significantly enhanced by isoproterenol in both groups of rats. Isoproterenol 46-59 renin Rattus norvegicus 0-5 2579903-7 1985 The basal level of renin measured when the glomeruli were superfused with BSA-Krebs was two to three times greater than when they were superfused with Krebs alone (p less than 0.001). krebs 151-156 renin Rattus norvegicus 19-24 2981315-6 1985 5"-N-Ethylcarboxamide adenosine and adenosine decreased total and segmental (afferent and efferent) resistances and stimulated renin secretion. Adenosine 22-31 renin Rattus norvegicus 127-132 2981315-1 1985 Exogenous adenosine inhibits renin secretion and can either vasoconstrict or vasodilate the renal vasculature in vivo. Adenosine 10-19 renin Rattus norvegicus 29-34 4041049-1 1985 Injections of pentobarbital have been shown to produce drinking in both deprived and nondeprived rats and a number of other studies have shown that pentobarbital is a potent renin releasor. Pentobarbital 14-27 renin Rattus norvegicus 174-179 2981315-2 1985 In previous experiments, we found that micromolar concentrations of N6-cyclohexyl adenosine and 5"-N-ethylcarboxamide adenosine, analogs which are relatively selective for A1 and A2 adenosine receptors, respectively, tended to have opposite effects on both afferent arteriolar resistance and renin secretory rate in isolated rat kidneys perfused at constant pressure. N(6)-cyclohexyladenosine 68-91 renin Rattus norvegicus 292-297 2981315-2 1985 In previous experiments, we found that micromolar concentrations of N6-cyclohexyl adenosine and 5"-N-ethylcarboxamide adenosine, analogs which are relatively selective for A1 and A2 adenosine receptors, respectively, tended to have opposite effects on both afferent arteriolar resistance and renin secretory rate in isolated rat kidneys perfused at constant pressure. 5"-n-ethylcarboxamide adenosine 96-127 renin Rattus norvegicus 292-297 2981315-6 1985 5"-N-Ethylcarboxamide adenosine and adenosine decreased total and segmental (afferent and efferent) resistances and stimulated renin secretion. 5"-n-ethylcarboxamide adenosine 0-31 renin Rattus norvegicus 127-132 3001555-1 1985 The renin angiotensin aldosterone system (RAAS) is activated during the early phase of renal adaptation to sodium restriction. Sodium 107-113 renin Rattus norvegicus 4-9 4041049-1 1985 Injections of pentobarbital have been shown to produce drinking in both deprived and nondeprived rats and a number of other studies have shown that pentobarbital is a potent renin releasor. Pentobarbital 148-161 renin Rattus norvegicus 174-179 3895329-0 1985 Participation of prostaglandin and adrenergic nervous system in renin release induced by changes in renal arterial pressure in rats. Prostaglandins 17-30 renin Rattus norvegicus 64-69 3933034-6 1985 Since all treatments can modulate activity in the renin-angiotension system, this system appears to play a role in altering some of the behavioral properties of ethanol. Ethanol 161-168 renin Rattus norvegicus 50-55 6508852-5 1984 Protection against DTT inactivation was obtained by preincubating membranes with unlabelled angiotensin II greater than angiotensin I greater than renin substrate while the dipeptide, Ileu-His was only effective in protecting the binding site at high concentrations (10 mM). Dithiothreitol 19-22 renin Rattus norvegicus 147-152 6149822-7 1984 Plasma renin and epinephrine levels at the peak of the pressor response to intracerebroventricularly administered ouabain were respectively, about 2.5- and 2-fold higher than in control rats. Ouabain 114-121 renin Rattus norvegicus 7-12 6149822-8 1984 Our data indicate that ouabain administered into the central nervous system produces a hypertensive effect which does not primarily involve peripheral alpha-adrenergic receptors, but appears to be due to angiotensin II produced by renin of renal origin. Ouabain 23-30 renin Rattus norvegicus 231-236 6149822-9 1984 These data suggest that digitalis agents can interact with sites in the central nervous system to induce a release of renin from the kidney; this release appears to involve activation of beta-adrenergic receptors by catecholamines from the adrenal medulla, perhaps through a direct adrenal-kidney vascular network. Catecholamines 216-230 renin Rattus norvegicus 118-123 3859104-0 1985 Interactions between muzolimine, PgE2 and the renin-angiotensin-aldosterone system. Muzolimine 21-31 renin Rattus norvegicus 46-51 3859104-0 1985 Interactions between muzolimine, PgE2 and the renin-angiotensin-aldosterone system. Dinoprostone 33-37 renin Rattus norvegicus 46-51 3859104-1 1985 UNLABELLED: The aim of our study was to determine the possible interrelation between muzolimine and the renal PG and renin-angiotensin systems by direct assay of these renal hormones. Muzolimine 85-95 renin Rattus norvegicus 117-122 6097077-0 1984 6-methoxy-tetrahydro-beta-carboline (pinoline): effects on plasma renin activity and aldosterone, TSH, LH and beta-endorphin levels in rats. 6-methoxytryptoline 37-45 renin Rattus norvegicus 66-71 6391206-5 1984 Plasma renin activity (PRA) was unchanged 3, 7, and 14 days after captopril cessation but was elevated at 28, 49, and 56 days after captopril cessation only in 2K, 1C rats with severe hypertension (systolic blood pressure greater than 180 mmHg). Captopril 66-75 renin Rattus norvegicus 7-12 6391206-5 1984 Plasma renin activity (PRA) was unchanged 3, 7, and 14 days after captopril cessation but was elevated at 28, 49, and 56 days after captopril cessation only in 2K, 1C rats with severe hypertension (systolic blood pressure greater than 180 mmHg). Captopril 132-141 renin Rattus norvegicus 7-12 3895329-8 1985 The hydralazine-induced renin release was remarkably suppressed by either indomethacin Or propranolol. Hydralazine 4-15 renin Rattus norvegicus 24-29 3895329-8 1985 The hydralazine-induced renin release was remarkably suppressed by either indomethacin Or propranolol. Indomethacin 74-86 renin Rattus norvegicus 24-29 3895329-8 1985 The hydralazine-induced renin release was remarkably suppressed by either indomethacin Or propranolol. Propranolol 90-101 renin Rattus norvegicus 24-29 3895329-9 1985 These results suggest that SAC-induced renin release is mainly dependent on the prostaglandin system, whereas hydralazine-induced renin release is dependent on the prostaglandin and the adrenergic nervous system. Hydralazine 110-121 renin Rattus norvegicus 130-135 6100756-15 1984 In conclusion, both captopril and MK-422 prevent the development of hypertension in SHR, presumably by blocking angiotensin-converting enzyme, suggesting that the brain renin-angiotensin system contributes to the pathogenesis of hypertension in that model. Captopril 20-29 renin Rattus norvegicus 169-174 6100756-15 1984 In conclusion, both captopril and MK-422 prevent the development of hypertension in SHR, presumably by blocking angiotensin-converting enzyme, suggesting that the brain renin-angiotensin system contributes to the pathogenesis of hypertension in that model. Enalaprilat 34-40 renin Rattus norvegicus 169-174 6096938-0 1984 Effect of calcium, sodium and isoproterenol on renin secretion from disaggregated rat renal cortical cells. Calcium 10-17 renin Rattus norvegicus 47-52 6396104-3 1984 Treatment with either trypsin or glandular kallikrein of the brain tissue caused a rapid and apparent increase in the renin activity at either 0 or 27 degrees C. The molecular weight of the active renin was estimated to be 40,000 daltons, while that of the trypsin-activatable inactive renin was found to be 48,000 or 61,000 daltons on a column chromatography with Sephadex G-100. sephadex 365-379 renin Rattus norvegicus 118-123 6396104-3 1984 Treatment with either trypsin or glandular kallikrein of the brain tissue caused a rapid and apparent increase in the renin activity at either 0 or 27 degrees C. The molecular weight of the active renin was estimated to be 40,000 daltons, while that of the trypsin-activatable inactive renin was found to be 48,000 or 61,000 daltons on a column chromatography with Sephadex G-100. sephadex 365-379 renin Rattus norvegicus 197-202 6396104-3 1984 Treatment with either trypsin or glandular kallikrein of the brain tissue caused a rapid and apparent increase in the renin activity at either 0 or 27 degrees C. The molecular weight of the active renin was estimated to be 40,000 daltons, while that of the trypsin-activatable inactive renin was found to be 48,000 or 61,000 daltons on a column chromatography with Sephadex G-100. sephadex 365-379 renin Rattus norvegicus 197-202 6096245-5 1984 A significant negative correlation was found between corticosterone and PRA, which suggest that changes in PRA were due to changes in circulating corticosterone, via feedback mechanism on renin secretion. Corticosterone 53-67 renin Rattus norvegicus 188-193 6096245-5 1984 A significant negative correlation was found between corticosterone and PRA, which suggest that changes in PRA were due to changes in circulating corticosterone, via feedback mechanism on renin secretion. Corticosterone 146-160 renin Rattus norvegicus 188-193 6084759-6 1984 As expected, rats maintained on the low-sodium regimen for either 5 or 21 days had marked stimulation of plasma renin activity and increased angiotensin I, angiotensin II, and aldosterone formation. Sodium 40-46 renin Rattus norvegicus 112-117 6396524-0 1984 Pharmacological evidence that the sympathetic nervous system mediates the increase in secretion of renin produced by p-chloroamphetamine. p-Chloroamphetamine 117-136 renin Rattus norvegicus 99-104 6396524-1 1984 The increase in plasma renin activity produced by p-chloroamphetamine in unanesthetized rats is blocked by p-chlorophenylalanine and by lesions of the dorsal raphe nucleus and the mediobasal hypothalamus. p-Chloroamphetamine 50-69 renin Rattus norvegicus 23-28 6396524-1 1984 The increase in plasma renin activity produced by p-chloroamphetamine in unanesthetized rats is blocked by p-chlorophenylalanine and by lesions of the dorsal raphe nucleus and the mediobasal hypothalamus. Fenclonine 107-128 renin Rattus norvegicus 23-28 6396524-2 1984 To determine whether the pathway from these areas of the brain to the kidneys that mediates the renin response is sympathetic, the effect of beta-adrenergic blockade and ganglionic blockade on the renin response to p-chloroamphetamine was studied. p-Chloroamphetamine 215-234 renin Rattus norvegicus 197-202 6396524-3 1984 The increase in plasma renin activity 60 min after the administration of p-chloroamphetamine (10 mg/kg, i.p.) p-Chloroamphetamine 73-92 renin Rattus norvegicus 23-28 6396524-8 1984 injected 30 min before p-chloroamphetamine also blocked the renin response. p-Chloroamphetamine 23-42 renin Rattus norvegicus 60-65 6396524-9 1984 The ganglionic-blocking drug chlorisondamine lowered blood pressure and increased plasma renin activity by itself. Chlorisondamine 29-44 renin Rattus norvegicus 89-94 6396524-11 1984 Chlorisondamine, by itself, did not produce maximal secretion of renin, since isoproterenol, 30 min after chlorisondamine, produced a large increase in plasma renin activity. Isoproterenol 78-91 renin Rattus norvegicus 159-164 6396524-12 1984 The data indicate that the increase in plasma renin activity produced by p-chloroamphetamine is mediated via the sympathetic nervous system. p-Chloroamphetamine 73-92 renin Rattus norvegicus 46-51 6386441-3 1984 Leydig cells of both populations also exhibited an inactive (latent) renin which was activated by the sulfhydryl reagents dithiothreitol, beta-mercaptoethanol, glutathione, and cysteine but not by limited proteolysis by trypsin, which is a characteristic activating agent for prorenin or inactive renin of the zymogen type. Dithiothreitol 122-136 renin Rattus norvegicus 69-74 6386441-3 1984 Leydig cells of both populations also exhibited an inactive (latent) renin which was activated by the sulfhydryl reagents dithiothreitol, beta-mercaptoethanol, glutathione, and cysteine but not by limited proteolysis by trypsin, which is a characteristic activating agent for prorenin or inactive renin of the zymogen type. Mercaptoethanol 138-158 renin Rattus norvegicus 69-74 6386441-3 1984 Leydig cells of both populations also exhibited an inactive (latent) renin which was activated by the sulfhydryl reagents dithiothreitol, beta-mercaptoethanol, glutathione, and cysteine but not by limited proteolysis by trypsin, which is a characteristic activating agent for prorenin or inactive renin of the zymogen type. Glutathione 160-171 renin Rattus norvegicus 69-74 6386441-3 1984 Leydig cells of both populations also exhibited an inactive (latent) renin which was activated by the sulfhydryl reagents dithiothreitol, beta-mercaptoethanol, glutathione, and cysteine but not by limited proteolysis by trypsin, which is a characteristic activating agent for prorenin or inactive renin of the zymogen type. Cysteine 177-185 renin Rattus norvegicus 69-74 6386441-4 1984 The activation of latent renin by dithiothreitol produced approximately 5-and 10-fold increases in renin activity in Leydig cell populations I and II, respectively. Dithiothreitol 34-48 renin Rattus norvegicus 25-30 6386441-4 1984 The activation of latent renin by dithiothreitol produced approximately 5-and 10-fold increases in renin activity in Leydig cell populations I and II, respectively. Dithiothreitol 34-48 renin Rattus norvegicus 99-104 6386441-5 1984 Active and latent renin showed strong affinity to an antirat renin immunoglobulin-Sepharose column, indicating a close immunological relationship of latent renin to active renin. Sepharose 82-91 renin Rattus norvegicus 18-23 6386441-5 1984 Active and latent renin showed strong affinity to an antirat renin immunoglobulin-Sepharose column, indicating a close immunological relationship of latent renin to active renin. Sepharose 82-91 renin Rattus norvegicus 61-66 6386441-5 1984 Active and latent renin showed strong affinity to an antirat renin immunoglobulin-Sepharose column, indicating a close immunological relationship of latent renin to active renin. Sepharose 82-91 renin Rattus norvegicus 61-66 6386441-5 1984 Active and latent renin showed strong affinity to an antirat renin immunoglobulin-Sepharose column, indicating a close immunological relationship of latent renin to active renin. Sepharose 82-91 renin Rattus norvegicus 61-66 6397583-0 1984 Conversion of low molecular weight renin into the high molecular weight form by Cu2+ in the rat kidney. cupric ion 80-84 renin Rattus norvegicus 35-40 6397583-5 1984 The reactivity in the formation of high molecular weight renin catalyzed by Cu2+ increased when the extract was previously dialyzed, indicating the presence of substance(s) that interfere with the binding reaction of renin. cupric ion 76-80 renin Rattus norvegicus 57-62 6397583-5 1984 The reactivity in the formation of high molecular weight renin catalyzed by Cu2+ increased when the extract was previously dialyzed, indicating the presence of substance(s) that interfere with the binding reaction of renin. cupric ion 76-80 renin Rattus norvegicus 217-222 6397583-6 1984 The high molecular weight renin produced by Cu2+ was stable against dithiothreitol, suggesting that the formation of disulphide bridge(s) is not involved in the reaction of renin with the renin binding substance. cupric ion 44-48 renin Rattus norvegicus 26-31 6397583-6 1984 The high molecular weight renin produced by Cu2+ was stable against dithiothreitol, suggesting that the formation of disulphide bridge(s) is not involved in the reaction of renin with the renin binding substance. Dithiothreitol 68-82 renin Rattus norvegicus 26-31 6397583-6 1984 The high molecular weight renin produced by Cu2+ was stable against dithiothreitol, suggesting that the formation of disulphide bridge(s) is not involved in the reaction of renin with the renin binding substance. disulphide 117-127 renin Rattus norvegicus 26-31 6397583-7 1984 We also confirmed that for formation of the high molecular weight renin, Cu2+ must react with both the renin enzyme and the renin binding substance. cupric ion 73-77 renin Rattus norvegicus 66-71 6397583-7 1984 We also confirmed that for formation of the high molecular weight renin, Cu2+ must react with both the renin enzyme and the renin binding substance. cupric ion 73-77 renin Rattus norvegicus 103-108 6397583-7 1984 We also confirmed that for formation of the high molecular weight renin, Cu2+ must react with both the renin enzyme and the renin binding substance. cupric ion 73-77 renin Rattus norvegicus 103-108 6096938-0 1984 Effect of calcium, sodium and isoproterenol on renin secretion from disaggregated rat renal cortical cells. Isoproterenol 30-43 renin Rattus norvegicus 47-52 6096938-5 1984 Incubation of cell suspensions with the beta-adrenergic agonist L-isoproterenol (ISO) significantly increased the activity of renin released into the incubation media. LEVISOPRENALINE 64-79 renin Rattus norvegicus 126-131 6096938-5 1984 Incubation of cell suspensions with the beta-adrenergic agonist L-isoproterenol (ISO) significantly increased the activity of renin released into the incubation media. iso 81-84 renin Rattus norvegicus 126-131 6096938-7 1984 The apparent ED50 for stimulation of renin release by ISO was 6 X 10(-8)M and the response was antagonized by the beta-adrenergic antagonist dl-propranolol. iso 54-57 renin Rattus norvegicus 37-42 6096938-7 1984 The apparent ED50 for stimulation of renin release by ISO was 6 X 10(-8)M and the response was antagonized by the beta-adrenergic antagonist dl-propranolol. Propranolol 141-155 renin Rattus norvegicus 37-42 6096938-8 1984 The spontaneous release of renin was also suppressed by increasing the concentration of extracellular calcium, whereas sodium ions had no effect on this process. Calcium 102-109 renin Rattus norvegicus 27-32 6098235-1 1984 The relationship between sodium homeostasis and the renin-angiotensin system was assessed through the use of two angiotensin-converting enzyme inhibitors (captopril and enalapril) in the rat. Sodium 25-31 renin Rattus norvegicus 52-57 6384392-5 1984 Captopril caused an increase in renin activity and a decrease in plasma aldosterone concentrations. Captopril 0-9 renin Rattus norvegicus 32-37 6384268-5 1984 An identical dose of the synthetic tetradecaptide of renin substrate (TDCP-RS) increased pressure similarly to AI. tetradecaptide 35-49 renin Rattus norvegicus 53-58 6384268-6 1984 The pressure increase evoked by TDCP-RS was markedly decreased by captopril and by two different peptides that inhibit renin. tdcp-rs 32-39 renin Rattus norvegicus 119-124 6386128-5 1984 Renal plasma flow was decreased by cyclohexyladenosine, without a corresponding increase in the arteriorenal venous difference in plasma renin concentrations, and arterial plasma renin concentration decreased in all rats given cyclohexyladenosine, suggesting inhibition of renin secretion. cyclohexyladenosine 227-246 renin Rattus norvegicus 179-184 6089584-0 1984 Relationship between PG and beta-adrenergic pathways to renin release in rat renal cortical slices. Prostaglandins 21-23 renin Rattus norvegicus 56-61 6089584-1 1984 The precise importance of prostaglandin (PG) in the beta-adrenergic pathway to renin release is unresolved. Prostaglandins 26-39 renin Rattus norvegicus 79-84 6089584-1 1984 The precise importance of prostaglandin (PG) in the beta-adrenergic pathway to renin release is unresolved. Prostaglandins 41-43 renin Rattus norvegicus 79-84 6089584-9 1984 PGI2 was found to stimulate the release of renin in concentrations of 10(-7) M. The combination of submaximal stimulatory concentrations of PGI2 (10(-6) M, a 1.6-fold increment) and ISO (10(-6) M, a 1.7-fold increment) produced a synergistic increase in renin release (2.84-fold). Epoprostenol 0-4 renin Rattus norvegicus 43-48 6089584-9 1984 PGI2 was found to stimulate the release of renin in concentrations of 10(-7) M. The combination of submaximal stimulatory concentrations of PGI2 (10(-6) M, a 1.6-fold increment) and ISO (10(-6) M, a 1.7-fold increment) produced a synergistic increase in renin release (2.84-fold). Epoprostenol 0-4 renin Rattus norvegicus 254-259 6089584-9 1984 PGI2 was found to stimulate the release of renin in concentrations of 10(-7) M. The combination of submaximal stimulatory concentrations of PGI2 (10(-6) M, a 1.6-fold increment) and ISO (10(-6) M, a 1.7-fold increment) produced a synergistic increase in renin release (2.84-fold). Epoprostenol 140-144 renin Rattus norvegicus 43-48 6089584-11 1984 Rather, high concentrations of prostaglandins may increase the renin-releasing action of beta-agonists, thereby modulating the release of renin. Prostaglandins 31-45 renin Rattus norvegicus 63-68 6089584-11 1984 Rather, high concentrations of prostaglandins may increase the renin-releasing action of beta-agonists, thereby modulating the release of renin. Prostaglandins 31-45 renin Rattus norvegicus 138-143 6380888-6 1984 Aldosterone lowered plasma renin activity and reduced fluid (0.3% NaCl) intake; these effects were diminished when aldosterone and corticosterone were infused simultaneously. Aldosterone 0-11 renin Rattus norvegicus 27-32 6380888-6 1984 Aldosterone lowered plasma renin activity and reduced fluid (0.3% NaCl) intake; these effects were diminished when aldosterone and corticosterone were infused simultaneously. Aldosterone 115-126 renin Rattus norvegicus 27-32 6380888-6 1984 Aldosterone lowered plasma renin activity and reduced fluid (0.3% NaCl) intake; these effects were diminished when aldosterone and corticosterone were infused simultaneously. Corticosterone 131-145 renin Rattus norvegicus 27-32 6383845-4 1984 After captopril treatment, kidney renin content of SHR was still significantly lower than WKY. Captopril 6-15 renin Rattus norvegicus 34-39 6383845-5 1984 Because of the lower content of kidney renin in SHR and the proportionately greater increase in kidney renin content in SHR after captopril treatment than in WKY, it is proposed that a fundamental difference(s) in the control of the renin-angiotensin system exists in SHR, an effect which may or may not be related to SHR hypertension. Captopril 130-139 renin Rattus norvegicus 103-108 6383845-5 1984 Because of the lower content of kidney renin in SHR and the proportionately greater increase in kidney renin content in SHR after captopril treatment than in WKY, it is proposed that a fundamental difference(s) in the control of the renin-angiotensin system exists in SHR, an effect which may or may not be related to SHR hypertension. Captopril 130-139 renin Rattus norvegicus 103-108 11540833-8 1984 Neostigmine increases plasma VIP and plasma renin activity, and the VIP appears to be responsible for the increase in renin secretion, since the increase is not blocked by renal denervation or propranolol. Neostigmine 0-11 renin Rattus norvegicus 44-49 6383082-0 1984 Effects of meclofenamate on the renin response to aortic constriction in the rat. Meclofenamic Acid 11-24 renin Rattus norvegicus 32-37 6383082-1 1984 This study examines the role of the renal prostaglandin system in stimulus-secretion coupling for renal baroreceptor-dependent renin release in the anesthetized rat. Prostaglandins 42-55 renin Rattus norvegicus 127-132 6386128-5 1984 Renal plasma flow was decreased by cyclohexyladenosine, without a corresponding increase in the arteriorenal venous difference in plasma renin concentrations, and arterial plasma renin concentration decreased in all rats given cyclohexyladenosine, suggesting inhibition of renin secretion. cyclohexyladenosine 227-246 renin Rattus norvegicus 179-184 27786021-0 1984 The Inhibition of Rat Renin in Sodium Depleted and Renal Hypertensive Rats. Sodium 31-37 renin Rattus norvegicus 22-27 6738303-5 1984 The results of this study provide additional evidence indicating that an endogenous digoxin-like substance may play an important role in the maintenance of chronic low-renin hypertension induced by aortic coarctation. Digoxin 84-91 renin Rattus norvegicus 168-173 6518666-5 1984 The two compounds are effective at similar dose ranges and suppress renin secretion in the isolated kidney, while UDP, which is effective at lower doses and stimulates renin secretion, may act by a different mechanism. Uridine Diphosphate 114-117 renin Rattus norvegicus 168-173 6379148-7 1984 These results are inconsistent with the hypothesis that renal renin is an important determinant of adenosine-induced renal hemodynamic changes. Adenosine 99-108 renin Rattus norvegicus 62-67 6329658-0 1984 Role of the renin-angiotensin system in the regulation of late steps in aldosterone biosynthesis by sodium intake of potassium-deficient rats. Aldosterone 72-83 renin Rattus norvegicus 12-17 6329658-0 1984 Role of the renin-angiotensin system in the regulation of late steps in aldosterone biosynthesis by sodium intake of potassium-deficient rats. Sodium 100-106 renin Rattus norvegicus 12-17 6329658-0 1984 Role of the renin-angiotensin system in the regulation of late steps in aldosterone biosynthesis by sodium intake of potassium-deficient rats. Potassium 117-126 renin Rattus norvegicus 12-17 6329658-1 1984 The role of the renin-angiotensin system in the adaptation of late steps in aldosterone biosynthesis to sodium intake was studied in potassium-deficient rats. Aldosterone 76-87 renin Rattus norvegicus 16-21 6329658-1 1984 The role of the renin-angiotensin system in the adaptation of late steps in aldosterone biosynthesis to sodium intake was studied in potassium-deficient rats. Sodium 104-110 renin Rattus norvegicus 16-21 6329658-6 1984 Accordingly, the renin-angiotensin system plays an important but limited role in the control of late steps of aldosterone biosynthesis by sodium intake. Aldosterone 110-121 renin Rattus norvegicus 17-22 6329658-6 1984 Accordingly, the renin-angiotensin system plays an important but limited role in the control of late steps of aldosterone biosynthesis by sodium intake. Sodium 138-144 renin Rattus norvegicus 17-22 27786021-2 1984 Studies were undertaken in order to demonstrate the role of the renin-angiotensin system for blood pressure homeostasis in sodium depleted and renal hypertensive (acute and chronic) rats. Sodium 123-129 renin Rattus norvegicus 64-69 6331173-0 1984 Role of prostaglandins in renin secretion in the isolated kidney. Prostaglandins 8-22 renin Rattus norvegicus 26-31 6331173-1 1984 Prostaglandins (PG) stimulate renin secretion through a mechanism that does not require activation of the intrarenal vascular, macula densa (MD), or beta-adrenergic receptors. Prostaglandins 0-14 renin Rattus norvegicus 30-35 6331173-1 1984 Prostaglandins (PG) stimulate renin secretion through a mechanism that does not require activation of the intrarenal vascular, macula densa (MD), or beta-adrenergic receptors. Prostaglandins 16-18 renin Rattus norvegicus 30-35 6331173-2 1984 In the present study the isolated perfused rat kidney was used to study the role of PG as a mediator of renin secretion when extracellular calcium was decreased and after activation of each of the intrarenal receptors. Prostaglandins 84-86 renin Rattus norvegicus 104-109 6331173-3 1984 A decrease in extracellular calcium resulted in an increase in renin (from 2.1 to 4.5 ng ANG I/ml, P less than 0.01) and a decrease in PGE2 excretion (from 102 to 44 pg X min-1 X g-1, P less than 0.01). Calcium 28-35 renin Rattus norvegicus 63-68 6375797-0 1984 Frusemide releases renin in the rat kidney when prostacyclin synthesis is suppressed. Furosemide 0-9 renin Rattus norvegicus 19-24 6331173-5 1984 Following beta-receptor stimulation with isoproterenol, there was an increase in renin (from 2.1 to 6.6 ng ANG I/ml, P less than 0.01) not associated with changes in PGE2 excretion and not prevented by PG inhibition. Isoproterenol 41-54 renin Rattus norvegicus 81-86 6375797-1 1984 The effect of inhibiting prostaglandin (PG) synthesis on basal and frusemide-stimulated renin secretion was examined in the rat isolated perfused kidney. Prostaglandins 40-42 renin Rattus norvegicus 88-93 6375797-1 1984 The effect of inhibiting prostaglandin (PG) synthesis on basal and frusemide-stimulated renin secretion was examined in the rat isolated perfused kidney. Furosemide 67-76 renin Rattus norvegicus 88-93 6375797-3 1984 Treatment of rats with indomethacin (3.0 mg kg-1) reduced 6-keto PGF1 alpha excretion from 121.3 +/- 39.1 (n = 9) to 15.5 +/- 6.6 (n = 9) pg min-1 (P less than 0.02) but had no effect on basal renin secretion. Indomethacin 23-35 renin Rattus norvegicus 193-198 6099389-0 1984 Chronic captopril infusion in two-kidney, one clip rats with normal plasma renin concentration. Captopril 8-17 renin Rattus norvegicus 75-80 6375797-7 1984 Although renin secretion was increased during frusemide infusion, there was no significant difference between control (1,806 +/- 384 ng angiotensin I (AI) min-1) and treated (2,310 +/- 554 ng AI min-1) rats (P greater than 0.05). Furosemide 46-55 renin Rattus norvegicus 9-14 6375797-8 1984 Propranolol, at a dose (8 micrograms min-1) which suppressed renin secretion after isoprenaline stimulation, had no effect on the response to frusemide in indomethacin-treated rats. Propranolol 0-11 renin Rattus norvegicus 61-66 6375797-9 1984 These results demonstrate that frusemide-stimulated renin secretion in the rat kidney does not require intact renal PGI2 synthesis and is independent of beta-adrenergic mechanisms. Furosemide 31-40 renin Rattus norvegicus 52-57 6376991-4 1984 Isoproterenol increased renin release by approximately 100%. Isoproterenol 0-13 renin Rattus norvegicus 24-29 6397528-0 1984 An inhibitory effect of dietary polyunsaturated fatty acids on renin secretion in the isolated perfused rat kidney. Fatty Acids, Unsaturated 32-59 renin Rattus norvegicus 63-68 6397528-1 1984 The influence of dietary modification of polyunsaturated fatty acids (PUFA) on renin secretion, renal vascular tone and prostanoid excretion was studied in isolated perfused rat kidneys under basal conditions and in response to angiotensin II. Fatty Acids, Unsaturated 70-74 renin Rattus norvegicus 79-84 6328982-4 1984 The relationship between sodium homeostasis and the renin-angiotensin system was assessed through the use of captopril in the rat. Sodium 25-31 renin Rattus norvegicus 52-57 6328982-8 1984 They suggest that the renin-angiotensin system is probably indispensable in preventing sodium loss when dietary sodium is suppressed. Sodium 87-93 renin Rattus norvegicus 22-27 6328982-8 1984 They suggest that the renin-angiotensin system is probably indispensable in preventing sodium loss when dietary sodium is suppressed. Sodium 112-118 renin Rattus norvegicus 22-27 6397528-6 1984 As both the control group and the safflower oil group excreted similar levels of urinary prostaglandins, these results suggest that dietary enrichment with 20 energy % PUFA alters renin secretion by a prostaglandin-independent mechanism and that this may contribute to the lower blood pressures observed in these animals compared with the saturated fat-fed control group. saturated fat 339-352 renin Rattus norvegicus 180-185 6380781-0 1984 Effects of ascorbic acid and ferrous ions on renin release from renin granules of vitamin E-deficient rats. Ascorbic Acid 11-24 renin Rattus norvegicus 64-69 6380781-0 1984 Effects of ascorbic acid and ferrous ions on renin release from renin granules of vitamin E-deficient rats. ammonium ferrous sulfate 29-36 renin Rattus norvegicus 45-50 6380781-0 1984 Effects of ascorbic acid and ferrous ions on renin release from renin granules of vitamin E-deficient rats. ammonium ferrous sulfate 29-36 renin Rattus norvegicus 64-69 6380781-0 1984 Effects of ascorbic acid and ferrous ions on renin release from renin granules of vitamin E-deficient rats. Vitamin E 82-91 renin Rattus norvegicus 45-50 6380781-0 1984 Effects of ascorbic acid and ferrous ions on renin release from renin granules of vitamin E-deficient rats. Vitamin E 82-91 renin Rattus norvegicus 64-69 6088755-0 1984 Stimulant effects of W-7, a calmodulin-antagonist, on renin release from rat kidney cortical slices. W 7 21-24 renin Rattus norvegicus 54-59 6088755-1 1984 Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin-antagonist, on renin release was examined using rat kidney cortical slices. W 7 11-61 renin Rattus norvegicus 97-102 6088755-1 1984 Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin-antagonist, on renin release was examined using rat kidney cortical slices. W 7 63-66 renin Rattus norvegicus 97-102 6088755-3 1984 The stimulant effect of W-7 on renin release was abolished by the removal of calcium from the incubation medium. Calcium 77-84 renin Rattus norvegicus 31-36 6326598-3 1984 Plasma renin activity was higher in LNa animals, and blood pressure was renin dependent only in this group, as evidenced by the blood pressure response to 10 mg/kg captopril iv. Captopril 164-173 renin Rattus norvegicus 7-12 6093165-1 1984 Disturbances in body water and electrolytes that trigger sodium appetite, such as sodium depletion or hypovolemia, are potent activators of the renin-angiotensin system. Water 21-26 renin Rattus norvegicus 144-149 6093165-1 1984 Disturbances in body water and electrolytes that trigger sodium appetite, such as sodium depletion or hypovolemia, are potent activators of the renin-angiotensin system. Sodium 57-63 renin Rattus norvegicus 144-149 6093165-1 1984 Disturbances in body water and electrolytes that trigger sodium appetite, such as sodium depletion or hypovolemia, are potent activators of the renin-angiotensin system. Sodium 82-88 renin Rattus norvegicus 144-149 6326598-7 1984 Prazosin also markedly stimulated plasma renin activity rendering blood pressure renin dependent even in RNa rats. Prazosin 0-8 renin Rattus norvegicus 41-46 6326598-7 1984 Prazosin also markedly stimulated plasma renin activity rendering blood pressure renin dependent even in RNa rats. Prazosin 0-8 renin Rattus norvegicus 81-86 6323227-3 1984 In this study we investigated the role of the renin-angiotensin system in the development of tolerance to guanethidine in one-kidney, one-clip renovascular and spontaneously hypertensive rats (SHR) using the angiotensin-converting enzyme inhibitor captopril. Guanethidine 106-118 renin Rattus norvegicus 46-51 6323227-7 1984 These results suggest that the renin-angiotensin system plays a major role in the development of tolerance to guanethidine in SHR but not in one-kidney, one-clip renal hypertensive rats. Guanethidine 110-122 renin Rattus norvegicus 31-36 6368797-10 1984 We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release. Tetrodotoxin 21-33 renin Rattus norvegicus 161-166 6398334-0 1984 Non-specific inhibition of pressor agents in vivo by the renin inhibitor pepstatin A. pepstatin 73-84 renin Rattus norvegicus 57-62 6398334-1 1984 The specificity of pepstatin A as an inhibitor of the cardiovascular actions of renin injected into anaesthetized rats has been investigated. pepstatin 19-30 renin Rattus norvegicus 80-85 6398334-2 1984 Pepstatin A 70 micrograms/kg/min partially inhibited the pressor response to injected renin without affecting the pressor responses to injected angiotensin II, phenylephrine or vasopressin. pepstatin 0-11 renin Rattus norvegicus 86-91 6398334-3 1984 Pepstatin A 150 micrograms/kg/min also produced partial inhibition of injected renin, but in addition caused significant inhibition of the other pressor agents. pepstatin 0-11 renin Rattus norvegicus 79-84 6398334-4 1984 This was in contrast to the effects of the angiotensin converting enzyme inhibitor captopril, 100 micrograms/kg i.v., which caused greater inhibition of the renin pressor response than pepstatin A without affecting the pressor response to injected angiotensin II, phenylephrine or vasopressin. Captopril 83-92 renin Rattus norvegicus 157-162 6398334-6 1984 It is concluded that pepstatin A reduces the pressor responsiveness to injected pressor agents and that this non-specific cardiovascular activity limits the usefulness of pepstatin A as a pharmacological tool to inhibit renal renin in vivo. pepstatin 171-182 renin Rattus norvegicus 226-231 6368797-0 1984 Action and mechanism of action of veratrine on renin secretion from rat kidney slices. Veratrine 34-43 renin Rattus norvegicus 47-52 6369334-0 1984 Biphasic alteration of renin release by calcium. Calcium 40-47 renin Rattus norvegicus 23-28 6368797-1 1984 It is well known that norepinephrine released from the renal nerves stimulates the secretion of renin by a beta adrenergic mechanism. Norepinephrine 22-36 renin Rattus norvegicus 96-101 6368797-2 1984 In the present experiments, we investigated the effects of renin secretion of veratrine, which depolarizes nerve terminals and thereby causes transmitter release. Veratrine 78-87 renin Rattus norvegicus 59-64 6368797-4 1984 Veratrine (10-200 microM) stimulated renin secretion in a concentration-dependent manner. Veratrine 0-9 renin Rattus norvegicus 37-42 6368797-7 1984 Moreover, veratrine stimulated renin secretion in slices prepared from previously denervated kidneys; this response was not antagonized by timolol. Veratrine 10-19 renin Rattus norvegicus 31-36 6368797-8 1984 These results are consistent with the hypothesis that veratrine stimulates renin secretion by at least two mechanisms. Veratrine 54-63 renin Rattus norvegicus 75-80 6368797-10 1984 We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release. Tetrodotoxin 21-33 renin Rattus norvegicus 78-83 6368797-10 1984 We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release. Tetrodotoxin 21-33 renin Rattus norvegicus 161-166 6368797-10 1984 We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release. Veratrine 57-66 renin Rattus norvegicus 78-83 6368797-10 1984 We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release. Veratrine 57-66 renin Rattus norvegicus 161-166 6368797-10 1984 We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release. Veratrine 57-66 renin Rattus norvegicus 161-166 6369334-2 1984 Calcium reintroduction to calcium-deprived rat renal cortical slices caused an initial stimulation of renin release (30-40 min) followed by a period of suppression of release (4.5 hr). Calcium 0-7 renin Rattus norvegicus 102-107 6369334-2 1984 Calcium reintroduction to calcium-deprived rat renal cortical slices caused an initial stimulation of renin release (30-40 min) followed by a period of suppression of release (4.5 hr). Calcium 26-33 renin Rattus norvegicus 102-107 6369334-4 1984 Our results suggest that although renin release from juxtaglomerular cells can be both stimulated and inhibited by raising intracellular calcium, it is the inhibition of release that is the more persistent effect. Calcium 137-144 renin Rattus norvegicus 34-39 6142738-3 1984 n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. n-cholinomimetics 0-17 renin Rattus norvegicus 92-97 6322303-5 1984 Compared to the animals receiving normal concentrations of sodium chloride, those receiving high concentrations of sodium chloride or amino acids showed decreased plasma renin activity and plasma aldosterone concentrations. Sodium Chloride 115-130 renin Rattus norvegicus 170-175 6142738-3 1984 n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. n-cholinomimetics 0-17 renin Rattus norvegicus 254-259 6142738-3 1984 n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. Nicotine 19-27 renin Rattus norvegicus 92-97 6142738-3 1984 n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. Nicotine 19-27 renin Rattus norvegicus 254-259 6142738-3 1984 n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. cytisine 29-36 renin Rattus norvegicus 92-97 6362959-6 1984 Although the plasma renin concentration of recipients on a low sodium diet fell below that of unilaterally nephrectomized controls on a low sodium diet, it was higher than that of recipients on a normal diet. Sodium 63-69 renin Rattus norvegicus 20-25 6362959-6 1984 Although the plasma renin concentration of recipients on a low sodium diet fell below that of unilaterally nephrectomized controls on a low sodium diet, it was higher than that of recipients on a normal diet. Sodium 140-146 renin Rattus norvegicus 20-25 6142738-3 1984 n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. cytisine 29-36 renin Rattus norvegicus 254-259 6142738-3 1984 n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. n-cholinolytics 168-183 renin Rattus norvegicus 92-97 6142738-3 1984 n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. adiphenine 185-196 renin Rattus norvegicus 92-97 6142738-3 1984 n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. benzohexonium 198-211 renin Rattus norvegicus 92-97 6142738-6 1984 It is assumed that the renal cortex contains n-cholinoreactive systems that have a direct or mediated action on renin secretion and m-cholinoreactive systems that modulate the activity of the former systems. Nitrogen 25-26 renin Rattus norvegicus 112-117 6373590-2 1984 Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 is a new, potent, specific statine -containing renin inhibitor. iva-his 0-7 renin Rattus norvegicus 83-88 6327520-4 1984 However, hydralazine stimulated the renin-angiotensin system and elevated the plasma norepinephrine (NE) and epinephrine (E) levels, whereas MK-421 did not. Hydralazine 9-20 renin Rattus norvegicus 36-41 6697962-3 1984 Whereas angiotensinogen secreted by hepatoma cells and hepatocytes showed electrophoretic heterogeneity (mol wt, 52-62 X 10(3], tunicamycin-treated cells secreted only a single angiotensinogen species [mol wt, 48.3 +/- 0.7 X 10(3) (mean +/- SD)], which could be cleaved by renin. Tunicamycin 128-139 renin Rattus norvegicus 273-278 6697962-9 1984 4) The des-angiotensin I-angiotensinogen generated by renin treatment of the lysate had an electrophoretic mobility identical to that of des-AI-angiotensinogen produced by renin treatment of nonglycosylated angiotensinogen secreted by tunicamycin-treated hepatoma cells and hepatocytes. Tunicamycin 235-246 renin Rattus norvegicus 54-59 6697962-9 1984 4) The des-angiotensin I-angiotensinogen generated by renin treatment of the lysate had an electrophoretic mobility identical to that of des-AI-angiotensinogen produced by renin treatment of nonglycosylated angiotensinogen secreted by tunicamycin-treated hepatoma cells and hepatocytes. Tunicamycin 235-246 renin Rattus norvegicus 172-177 6373590-2 1984 Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 is a new, potent, specific statine -containing renin inhibitor. Proline 8-12 renin Rattus norvegicus 83-88 6373590-2 1984 Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 is a new, potent, specific statine -containing renin inhibitor. histidylphenylalanine 12-19 renin Rattus norvegicus 83-88 6373590-2 1984 Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 is a new, potent, specific statine -containing renin inhibitor. xylometazoline 20-23 renin Rattus norvegicus 83-88 6724865-7 1984 The present study suggests that verapamil can be used as a calcium blocker to reduce blood pressure associated with, or caused by, an increased renin-angiotensin system activity. Verapamil 32-41 renin Rattus norvegicus 144-149 6373590-2 1984 Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 is a new, potent, specific statine -containing renin inhibitor. Leucine 24-27 renin Rattus norvegicus 83-88 6373590-2 1984 Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 is a new, potent, specific statine -containing renin inhibitor. phenylalanine amide 28-35 renin Rattus norvegicus 83-88 6373590-2 1984 Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 is a new, potent, specific statine -containing renin inhibitor. statine 63-70 renin Rattus norvegicus 83-88 6373592-3 1984 Changes in sodium diet induced changes in adrenal capsular renin concentration (high Na 2.21 +/- 0.34, normal Na 4.34 +/- 0.53, low Na 13.19 +/- 1.67 ng AI/mg protein/hr). Sodium 11-17 renin Rattus norvegicus 59-64 6373592-4 1984 A high potassium diet also increased adrenal capsular renin from 5.27 +/- 0.53 to 39.78 +/- 5.68 ng AI/mg protein/hr, while plasma renin concentration decreased from 7.28 +/- 0.63 in the normal diet to 5.05 +/- 0.60 on the high potassium diet. Potassium 7-16 renin Rattus norvegicus 54-59 6373592-7 1984 Sodium loading or dexamethasone treatment prior to nephrectomy blunted the rise in adrenal renin (nephrectomy + dexamethasone = 27.64 +/- 4.33 ng AI/mg protein/hr; nephrectomy + NaCl = 38.70 +/- 5.82 ng AI/mg protein/hr). Sodium 0-6 renin Rattus norvegicus 91-96 6373592-7 1984 Sodium loading or dexamethasone treatment prior to nephrectomy blunted the rise in adrenal renin (nephrectomy + dexamethasone = 27.64 +/- 4.33 ng AI/mg protein/hr; nephrectomy + NaCl = 38.70 +/- 5.82 ng AI/mg protein/hr). Dexamethasone 18-31 renin Rattus norvegicus 91-96 6373592-7 1984 Sodium loading or dexamethasone treatment prior to nephrectomy blunted the rise in adrenal renin (nephrectomy + dexamethasone = 27.64 +/- 4.33 ng AI/mg protein/hr; nephrectomy + NaCl = 38.70 +/- 5.82 ng AI/mg protein/hr). Dexamethasone 112-125 renin Rattus norvegicus 91-96 6325675-11 1984 Nephrectomy (but not ligation of the ureters) or injections of propranolol (5 mg/kg, S.C.) to prevent renin secretion prevented the enhancement of deprivation-or serotonin-induced thirst by the low dose of captopril. Propranolol 63-74 renin Rattus norvegicus 102-107 6325675-11 1984 Nephrectomy (but not ligation of the ureters) or injections of propranolol (5 mg/kg, S.C.) to prevent renin secretion prevented the enhancement of deprivation-or serotonin-induced thirst by the low dose of captopril. Serotonin 162-171 renin Rattus norvegicus 102-107 6325675-19 1984 These findings suggest that the enhancement of drinking caused by low doses of captopril s.c. is a sensitive indicator of whether the renin- angiotensin system participates at all in the regulatory response to a particular stimulus to drink. Captopril 79-88 renin Rattus norvegicus 134-139 6373592-9 1984 In conclusion, adrenal renin may be a local hormone, involved in the regulation of aldosterone production. Aldosterone 83-94 renin Rattus norvegicus 23-28 6373594-4 1984 The activated form of latent renin in crude brain extract was again inactivated by the disulfide compound sodium tetrathionate. Disulfides 87-96 renin Rattus norvegicus 29-34 6373594-4 1984 The activated form of latent renin in crude brain extract was again inactivated by the disulfide compound sodium tetrathionate. Tetrathionic Acid 106-126 renin Rattus norvegicus 29-34 6373594-6 1984 In contrast to a marked (10-fold) increase of latent renin by dithiothreitol, the enzyme activity of active renin was increased by less than 50% by this sulfhydryl compound. Dithiothreitol 62-76 renin Rattus norvegicus 53-58 6373594-6 1984 In contrast to a marked (10-fold) increase of latent renin by dithiothreitol, the enzyme activity of active renin was increased by less than 50% by this sulfhydryl compound. Sulfhydryl Compounds 153-163 renin Rattus norvegicus 108-113 6373594-8 1984 Latent renin showed affinity for pepstatin-Sepharose gel. Sepharose 43-52 renin Rattus norvegicus 7-12 6373594-10 1984 Latent renin has a molecular weight of 45,000 and is reduced to 34,000 upon activation by dithiothreitol. Dithiothreitol 90-104 renin Rattus norvegicus 7-12 6323192-0 1984 Yohimbine induces sympathetically mediated renin release in the conscious rat. Yohimbine 0-9 renin Rattus norvegicus 43-48 6371955-2 1984 In this study, Cyclosporin A was shown to stimulate renin release in vitro in rat renal cortical slices. Cyclosporine 15-28 renin Rattus norvegicus 52-57 6371955-4 1984 This observation strengthens the hypothesis that the intra renal renin-angiotensin system may participate in the mechanism of Cyclosporin A nephrotoxicity. Cyclosporine 126-139 renin Rattus norvegicus 65-70 6364673-1 1984 To examine potassium homeostasis in diabetes mellitus, we observed the effect of dietary potassium loading on the renin-angiotensin-aldosterone system and potassium balance in streptozotocin-induced diabetic rats. Potassium 89-98 renin Rattus norvegicus 114-119 6364673-1 1984 To examine potassium homeostasis in diabetes mellitus, we observed the effect of dietary potassium loading on the renin-angiotensin-aldosterone system and potassium balance in streptozotocin-induced diabetic rats. Potassium 89-98 renin Rattus norvegicus 114-119 6371955-0 1984 Stimulation of renin release from rat renal cortical slices by cyclosporin A. Cyclosporine 63-76 renin Rattus norvegicus 15-20 6371955-1 1984 Cyclosporin A is known to produce increases in plasma and kidney renin in vivo. Cyclosporine 0-13 renin Rattus norvegicus 65-70 6373398-3 1984 Treatment with trypsin of the arterial tissue caused a rapid and apparent increase in the renin activity at either 0 or 27 degrees C. The molecular weight of the active renin was estimated to be 32,000 or 39,000, while that of the inactive renin was found to be 36,000 or 44,000 on Sephadex G-100 gel filtration. sephadex 282-296 renin Rattus norvegicus 90-95 6373398-3 1984 Treatment with trypsin of the arterial tissue caused a rapid and apparent increase in the renin activity at either 0 or 27 degrees C. The molecular weight of the active renin was estimated to be 32,000 or 39,000, while that of the inactive renin was found to be 36,000 or 44,000 on Sephadex G-100 gel filtration. sephadex 282-296 renin Rattus norvegicus 169-174 6373398-3 1984 Treatment with trypsin of the arterial tissue caused a rapid and apparent increase in the renin activity at either 0 or 27 degrees C. The molecular weight of the active renin was estimated to be 32,000 or 39,000, while that of the inactive renin was found to be 36,000 or 44,000 on Sephadex G-100 gel filtration. sephadex 282-296 renin Rattus norvegicus 169-174 6694527-1 1984 Renin substrate was characterized in incubation medium of isolated hepatocytes, plasma, and brain extracts of the rat by isoelectric focusing and polyacrylamide gel electrophoresis. polyacrylamide 146-160 renin Rattus norvegicus 0-5 6323192-1 1984 The preferential alpha 2-adrenergic antagonist yohimbine (4 mg/kg s.c.) caused a time-related increase in serum renin activity and heart rate in conscious Sprague-Dawley rats. Yohimbine 47-56 renin Rattus norvegicus 112-117 6694527-6 1984 Intraperitoneal injection of 17 beta estradiol (1 mg) or bilateral nephrectomy significantly elevated renin substrate levels in plasma and increased its release from hepatocytes, however, no change in the IEF or PAGE profiles was evident. Estradiol 29-46 renin Rattus norvegicus 102-107 6323192-4 1984 Yohimbine (0.3, 1, 3 and 10 mg/kg s.c.) elicited a dose-related increase in serum renin activity and heart rate (30 min post-injection). Yohimbine 0-9 renin Rattus norvegicus 82-87 6323192-7 1984 The beta-adrenergic receptor antagonist propranolol (1.5 mg/kg s.c.), blocked the renin release and tachycardia caused by yohimbine (1 and 3 mg/kg s.c.), and the ganglionic blocking agent chlorisondamine partially inhibited the renin release elicited by 3 mg/kg (s.c.) of yohimbine. Propranolol 40-51 renin Rattus norvegicus 82-87 6323192-7 1984 The beta-adrenergic receptor antagonist propranolol (1.5 mg/kg s.c.), blocked the renin release and tachycardia caused by yohimbine (1 and 3 mg/kg s.c.), and the ganglionic blocking agent chlorisondamine partially inhibited the renin release elicited by 3 mg/kg (s.c.) of yohimbine. Propranolol 40-51 renin Rattus norvegicus 228-233 6323192-7 1984 The beta-adrenergic receptor antagonist propranolol (1.5 mg/kg s.c.), blocked the renin release and tachycardia caused by yohimbine (1 and 3 mg/kg s.c.), and the ganglionic blocking agent chlorisondamine partially inhibited the renin release elicited by 3 mg/kg (s.c.) of yohimbine. Yohimbine 122-131 renin Rattus norvegicus 82-87 6323192-9 1984 Thus, the increase in renin release caused by yohimbine appears to be mediated by the sympathetic nervous system. Yohimbine 46-55 renin Rattus norvegicus 22-27 6323192-10 1984 Because the smaller doses of yohimbine increase renin release in the absence of a decrease in mean arterial pressure, it is unlikely that yohimbine stimulates renin release by baroreflex-mediated activation of the renal sympathetic nerves. Yohimbine 29-38 renin Rattus norvegicus 48-53 6143602-1 1984 The angiotensin I converting enzyme (ACE) inhibitor enalapril (MK-421), at a dose of 1 mg/kg or more by gavage twice daily, effectively inhibited the pressor response to angiotensin I for more than 12 h and less than 24 h. Plasma renin activity (PRA) did not change after 2 or 4 days of treatment at 1 mg/kg twice daily despite effective ACE inhibition, whereas it rose significantly at 10 mg/kg twice daily. Enalapril 52-61 renin Rattus norvegicus 230-235 6331067-11 1984 The simultaneous increase of PRA and PAC associated with decreased electrolyte excretion indicates that, in addition to antidiuretic hormone, also the renin-aldosterone-system probably play a relevant role in the renal excretory changes after morphine withdrawal. Morphine 243-251 renin Rattus norvegicus 151-156 6364834-5 1984 Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Saralasin 0-9 renin Rattus norvegicus 98-103 6364834-5 1984 Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Captopril 13-22 renin Rattus norvegicus 98-103 6143602-1 1984 The angiotensin I converting enzyme (ACE) inhibitor enalapril (MK-421), at a dose of 1 mg/kg or more by gavage twice daily, effectively inhibited the pressor response to angiotensin I for more than 12 h and less than 24 h. Plasma renin activity (PRA) did not change after 2 or 4 days of treatment at 1 mg/kg twice daily despite effective ACE inhibition, whereas it rose significantly at 10 mg/kg twice daily. Enalapril 63-69 renin Rattus norvegicus 230-235 6143602-5 1984 Propranolol significantly reduced the rise in plasma renin in rats receiving enalapril. Propranolol 0-11 renin Rattus norvegicus 53-58 6143602-5 1984 Propranolol significantly reduced the rise in plasma renin in rats receiving enalapril. Enalapril 77-86 renin Rattus norvegicus 53-58 6143602-9 1984 In conclusion, enalapril produced renin secretion, which was in part beta-adrenergically mediated. Enalapril 15-24 renin Rattus norvegicus 34-39 6398146-0 1984 Vasopressor responses to centrally-administered steroid hormones are mediated via a renin-angiotensin system in the rat brain. Steroids 48-64 renin Rattus norvegicus 84-89 6329559-7 1984 Blockade of the renin angiotensin system in SOR with the converting enzyme inhibitor, captopril, reduced BP responses to the same level as NXR. Captopril 86-95 renin Rattus norvegicus 16-21 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Angiotensin I/II (1-6) 53-76 renin Rattus norvegicus 31-36 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Angiotensin I/II (1-6) 53-76 renin Rattus norvegicus 176-181 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Proline 77-80 renin Rattus norvegicus 31-36 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Phenylalanine 81-84 renin Rattus norvegicus 31-36 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Histidine 73-76 renin Rattus norvegicus 31-36 6430607-0 1984 Suppression of bradykinin-induced renin release by indomethacin in anesthetized rats. Indomethacin 51-63 renin Rattus norvegicus 34-39 6399313-1 1984 Intracranial renin is a potent stimulus to sodium appetite and thirst, the effects being mediated by local generation of angiotensin II. Sodium 43-49 renin Rattus norvegicus 13-18 6430607-1 1984 The present study was designed to investigate the effect of bradykinin on renin release in relation to prostaglandins by use of indomethacin, a cyclooxygenase inhibitor, in pentobarbital-anesthetized rats. Pentobarbital 173-186 renin Rattus norvegicus 74-79 6430607-5 1984 These results suggest that bradykinin does not directly increase plasma renin activity and that prostaglandins may participate in the bradykinin-induced renin release under these experimental conditions. Prostaglandins 96-110 renin Rattus norvegicus 153-158 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Leucine 89-92 renin Rattus norvegicus 31-36 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Leucine 93-96 renin Rattus norvegicus 31-36 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Valine 61-64 renin Rattus norvegicus 31-36 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Tyrosine 65-68 renin Rattus norvegicus 31-36 6099783-1 1984 The synthetic tetradecapeptide renin substrate (TDP; Asp-arg-val-tyr-ile-his-pro-phe-his-leu-leu-val-tyr-ser) has been employed frequently to elucidate the enzymatic action of renin in vitro and, to a lesser extent, in vivo. Serine 105-108 renin Rattus norvegicus 31-36 6099783-7 1984 Intravenous infusion of the renin inhibitor pepstatin (200 micrograms/min) inhibited pressor responses to hog renin by approximately 60%, but did not affect those to TDP. pepstatin 44-53 renin Rattus norvegicus 28-33 6099783-7 1984 Intravenous infusion of the renin inhibitor pepstatin (200 micrograms/min) inhibited pressor responses to hog renin by approximately 60%, but did not affect those to TDP. pepstatin 44-53 renin Rattus norvegicus 110-115 6099783-8 1984 Intravenous infusion of the water soluble renin inhibitor, pepstatinyl-arginine-o-methyl ester (500 micrograms/min), also inhibited pressor responses to renin (approx. Water 28-33 renin Rattus norvegicus 42-47 6099783-8 1984 Intravenous infusion of the water soluble renin inhibitor, pepstatinyl-arginine-o-methyl ester (500 micrograms/min), also inhibited pressor responses to renin (approx. Water 28-33 renin Rattus norvegicus 153-158 6099783-8 1984 Intravenous infusion of the water soluble renin inhibitor, pepstatinyl-arginine-o-methyl ester (500 micrograms/min), also inhibited pressor responses to renin (approx. pepstatinyl-arginine-o-methyl ester 59-94 renin Rattus norvegicus 42-47 6099783-8 1984 Intravenous infusion of the water soluble renin inhibitor, pepstatinyl-arginine-o-methyl ester (500 micrograms/min), also inhibited pressor responses to renin (approx. pepstatinyl-arginine-o-methyl ester 59-94 renin Rattus norvegicus 153-158 6099784-0 1984 Contribution of beta-adrenergic receptor mediated renin release to the maintenance of blood pressure during nitroprusside infusion in conscious rats. Nitroprusside 108-121 renin Rattus norvegicus 50-55 6099784-1 1984 The extent to which beta-adrenergic receptor mediated renin release contributes to the maintenance of blood pressure during hypotension induced by sodium nitroprusside (SNP, 40 micrograms/kg/min for 30 min) was assessed in conscious Wistar rats fitted with chronic aortic and vena caval catheters. Nitroprusside 147-167 renin Rattus norvegicus 54-59 6099784-5 1984 Treatment of these animals with captopril in order to block the actions of the remaining non-beta-receptor released renin, resulted in augmentation of the SNP hypotension. Captopril 32-41 renin Rattus norvegicus 116-121 6399313-3 1984 Increased circulating renin after captopril treatment in adrenalectomized rats (Elfont and Fitzsimons, 1981), or in renal hypertension following partial inter-renal aortic ligation (Costales et al., 1982), also leads to increased intakes of 2.7% NaCl and water. Captopril 34-43 renin Rattus norvegicus 22-27 6399313-3 1984 Increased circulating renin after captopril treatment in adrenalectomized rats (Elfont and Fitzsimons, 1981), or in renal hypertension following partial inter-renal aortic ligation (Costales et al., 1982), also leads to increased intakes of 2.7% NaCl and water. Sodium Chloride 246-250 renin Rattus norvegicus 22-27 6384653-6 1984 Further experiments were carried out in which nicotine was administered chronically over 4 weeks (implanted osmotic minipumps infusing 0.17 mg/kg) in rats in which the endogenous activity of the renin-angiotensin system was modified by either a low- or high-salt diet. Nicotine 46-54 renin Rattus norvegicus 195-200 6399313-3 1984 Increased circulating renin after captopril treatment in adrenalectomized rats (Elfont and Fitzsimons, 1981), or in renal hypertension following partial inter-renal aortic ligation (Costales et al., 1982), also leads to increased intakes of 2.7% NaCl and water. Water 255-260 renin Rattus norvegicus 22-27 6399315-5 1984 Renin secretion and renal inner medullary blood flow (tissue clearance of 133Xe) were simultaneously measured before and after frusemide-induced renin release. Furosemide 127-136 renin Rattus norvegicus 145-150 6399315-9 1984 Inhibition of renin release by propranolol or AII-blockade (by saralasin or Hoe 409) delayed recovery of urinary osmolality. Propranolol 31-42 renin Rattus norvegicus 14-19 6399315-9 1984 Inhibition of renin release by propranolol or AII-blockade (by saralasin or Hoe 409) delayed recovery of urinary osmolality. Saralasin 63-72 renin Rattus norvegicus 14-19 6399315-9 1984 Inhibition of renin release by propranolol or AII-blockade (by saralasin or Hoe 409) delayed recovery of urinary osmolality. 4-hydroxy-2-octenal 76-79 renin Rattus norvegicus 14-19 6399315-11 1984 Its vasoconstrictive action on the efferent glomerular arteriole might enable the renin-angiotensin system to participate in the control of renal excretion of salt and water. Salts 159-163 renin Rattus norvegicus 82-87 6399315-11 1984 Its vasoconstrictive action on the efferent glomerular arteriole might enable the renin-angiotensin system to participate in the control of renal excretion of salt and water. Water 168-173 renin Rattus norvegicus 82-87 6385168-0 1984 Changes in salt intake alter the release of multiple renin species in a nonuniform manner. Salts 11-15 renin Rattus norvegicus 53-58 6362426-0 1983 Suppression of renin secretion by insulin: dependence on extracellular calcium. Calcium 71-78 renin Rattus norvegicus 15-20 6206557-0 1984 The inhibition of rat renin in sodium depleted and renal hypertensive rats. Sodium 31-37 renin Rattus norvegicus 22-27 6206557-2 1984 Studies were undertaken in order to demonstrate the role of the renin-angiotensin system for blood pressure homeostasis in sodium depleted and renal hypertensive (acute and chronic) rats. Sodium 123-129 renin Rattus norvegicus 64-69 6316059-0 1983 Influence of adrenergic nervous and prostaglandin systems on hydralazine-induced renin release. Hydralazine 61-72 renin Rattus norvegicus 81-86 6316059-2 1983 The plasma renin activity (PRA) response to intravenous hydralazine (0.25, 0.5 and 1 mg/kg body wt.) Hydralazine 56-67 renin Rattus norvegicus 11-16 6316059-11 1983 These results demonstrate that vasodilator-induced renin release is only partially mediated via the prostaglandin system, that the degree of this control is related to the intensity of vasodilator stimulus and that renin release following administration of hydralazine can be attributed almost entirely to activation of the beta-adrenergic nervous and prostaglandin systems. Prostaglandins 100-113 renin Rattus norvegicus 51-56 6316059-11 1983 These results demonstrate that vasodilator-induced renin release is only partially mediated via the prostaglandin system, that the degree of this control is related to the intensity of vasodilator stimulus and that renin release following administration of hydralazine can be attributed almost entirely to activation of the beta-adrenergic nervous and prostaglandin systems. Hydralazine 257-268 renin Rattus norvegicus 51-56 6316059-11 1983 These results demonstrate that vasodilator-induced renin release is only partially mediated via the prostaglandin system, that the degree of this control is related to the intensity of vasodilator stimulus and that renin release following administration of hydralazine can be attributed almost entirely to activation of the beta-adrenergic nervous and prostaglandin systems. Hydralazine 257-268 renin Rattus norvegicus 215-220 6316059-11 1983 These results demonstrate that vasodilator-induced renin release is only partially mediated via the prostaglandin system, that the degree of this control is related to the intensity of vasodilator stimulus and that renin release following administration of hydralazine can be attributed almost entirely to activation of the beta-adrenergic nervous and prostaglandin systems. Prostaglandins 352-365 renin Rattus norvegicus 215-220 6360207-3 1983 The renin component was purified further by passage through an anti-rat spleen cathepsin D immunoglobulin G-Sepharose (IgG-Sepharose) column followed by carboxymethyl-Sephadex (CM-Sepharose) chromatography which separated two renin components. Sepharose 108-117 renin Rattus norvegicus 4-9 6357765-2 1983 Plasma renin concentration (PRC) responses to acute infusion of 0.9% NaCl (5% of body weight) were compared in three groups of rats: Adx, Adx rats treated with dexamethasone (Adx + Dex), and sham controls. Sodium Chloride 69-73 renin Rattus norvegicus 7-12 6357765-8 1983 These results are consistent with the hypothesis that altered responsiveness to NaCl, in the absence of volume contraction, contributes to increased renin release in adrenal insufficiency. Sodium Chloride 80-84 renin Rattus norvegicus 149-154 6357765-9 1983 Glucocorticoid replacement restored renin responsiveness to NaCl. Sodium Chloride 60-64 renin Rattus norvegicus 36-41 6424149-1 1984 Renin-like activity in the heart and aorta of rats being slightly modified by binephrectomy, its variations in DOCA hypertension and infarcted ventricular muscle were studied. Desoxycorticosterone Acetate 111-115 renin Rattus norvegicus 0-5 6424149-3 1984 administration of DOCA 12 mg/kg body weight for 35 days in male adult rats resulted in a significant decrease of renin activity in plasma and tissues of the heart, aorta, hypothalamus and hypophysis. Desoxycorticosterone Acetate 18-22 renin Rattus norvegicus 113-118 6424149-5 1984 Similar changes of renin-like activity were observed in salt-loaded animals with 1.7% sodium chloride solution ad libitum for 35 days. Salts 56-60 renin Rattus norvegicus 19-24 6424149-5 1984 Similar changes of renin-like activity were observed in salt-loaded animals with 1.7% sodium chloride solution ad libitum for 35 days. Sodium Chloride 86-101 renin Rattus norvegicus 19-24 6360207-3 1983 The renin component was purified further by passage through an anti-rat spleen cathepsin D immunoglobulin G-Sepharose (IgG-Sepharose) column followed by carboxymethyl-Sephadex (CM-Sepharose) chromatography which separated two renin components. Sepharose 123-132 renin Rattus norvegicus 4-9 6360207-3 1983 The renin component was purified further by passage through an anti-rat spleen cathepsin D immunoglobulin G-Sepharose (IgG-Sepharose) column followed by carboxymethyl-Sephadex (CM-Sepharose) chromatography which separated two renin components. carboxymethyl-sephadex 153-175 renin Rattus norvegicus 4-9 6360207-3 1983 The renin component was purified further by passage through an anti-rat spleen cathepsin D immunoglobulin G-Sepharose (IgG-Sepharose) column followed by carboxymethyl-Sephadex (CM-Sepharose) chromatography which separated two renin components. Sepharose 123-132 renin Rattus norvegicus 4-9 6360871-1 1983 Effect on urinary prostaglandin E2 and plasma renin in response to variations in sodium intake and in relation to blood pressure. Sodium 81-87 renin Rattus norvegicus 46-51 6197374-4 1983 The effect of aprotinin on PRA was further studied in conscious rats before and after stimulation of renin release by isoproterenol or furosemide. Isoproterenol 118-131 renin Rattus norvegicus 101-106 6366185-3 1983 When kidney cortical slices were incubated in a Krebs-Ringers" bicarbonate solution (pH 7.4) at 37 degrees C, the rate of renin release into the incubation medium in vitamin E-deficient group was significantly higher than that in the control group. Vitamin E 166-175 renin Rattus norvegicus 122-127 6366184-0 1983 Effects of vitamin E depletion and repletion on renin release from renin granules. Vitamin E 11-20 renin Rattus norvegicus 48-53 6366184-0 1983 Effects of vitamin E depletion and repletion on renin release from renin granules. Vitamin E 11-20 renin Rattus norvegicus 67-72 6366184-1 1983 The present study was carried out to investigate the effects of vitamin E-deficiency and supplementation of alpha-tocopheryl acetate (TOCA) on renin release from renin granules. alpha-Tocopherol 108-132 renin Rattus norvegicus 143-148 6366184-1 1983 The present study was carried out to investigate the effects of vitamin E-deficiency and supplementation of alpha-tocopheryl acetate (TOCA) on renin release from renin granules. alpha-Tocopherol 108-132 renin Rattus norvegicus 162-167 6366185-4 1983 However, dietary supplementation of alpha-tocopheryl acetate (TOCA) or N,N"-diphenyl-p-phenylenediamine (DPPD) to the vitamin E-deficient rats for 5 d suppressed the stimulation of renin release from kidney cortical slices by vitamin E-deficiency. alpha-Tocopherol 36-60 renin Rattus norvegicus 181-186 6366184-4 1983 The intake of vitamin E-deficient diet for 4 weeks resulted in an increased level of endogenous lipid peroxides in the renin granule fraction, accompanied by a marked decrease in alpha-tocopherol content, and led to a significant increase in the rate of renin release from the granules during incubation at 37 degrees C. These changes in alpha-tocopherol content, lipid peroxide level and renin release in the renin granule fraction were restored to the control values by dietary TOCA supplementation. Lipid Peroxides 96-111 renin Rattus norvegicus 119-124 6366185-4 1983 However, dietary supplementation of alpha-tocopheryl acetate (TOCA) or N,N"-diphenyl-p-phenylenediamine (DPPD) to the vitamin E-deficient rats for 5 d suppressed the stimulation of renin release from kidney cortical slices by vitamin E-deficiency. alpha-Tocopherol 62-66 renin Rattus norvegicus 181-186 6366184-4 1983 The intake of vitamin E-deficient diet for 4 weeks resulted in an increased level of endogenous lipid peroxides in the renin granule fraction, accompanied by a marked decrease in alpha-tocopherol content, and led to a significant increase in the rate of renin release from the granules during incubation at 37 degrees C. These changes in alpha-tocopherol content, lipid peroxide level and renin release in the renin granule fraction were restored to the control values by dietary TOCA supplementation. Lipid Peroxides 96-110 renin Rattus norvegicus 119-124 6366185-4 1983 However, dietary supplementation of alpha-tocopheryl acetate (TOCA) or N,N"-diphenyl-p-phenylenediamine (DPPD) to the vitamin E-deficient rats for 5 d suppressed the stimulation of renin release from kidney cortical slices by vitamin E-deficiency. N,N'-diphenyl-4-phenylenediamine 71-103 renin Rattus norvegicus 181-186 6366184-5 1983 Similarly, dietary supplementation of N,N"-diphenyl-p-phenylenediamine (80 mg/100 g diet), which has an antioxidative ability, suppressed the increases in lipid peroxidation and renin release due to vitamin E-deficiency, although this compound was ineffective in restoring alpha-tocopherol levels. N,N'-diphenyl-4-phenylenediamine 38-70 renin Rattus norvegicus 178-183 6366184-6 1983 These results suggest that vitamin E functions in maintenance of membrane integrity of renin granules by inhibiting the lipid peroxidation. Vitamin E 27-36 renin Rattus norvegicus 87-92 6366185-4 1983 However, dietary supplementation of alpha-tocopheryl acetate (TOCA) or N,N"-diphenyl-p-phenylenediamine (DPPD) to the vitamin E-deficient rats for 5 d suppressed the stimulation of renin release from kidney cortical slices by vitamin E-deficiency. N,N'-diphenyl-4-phenylenediamine 105-109 renin Rattus norvegicus 181-186 6366185-3 1983 When kidney cortical slices were incubated in a Krebs-Ringers" bicarbonate solution (pH 7.4) at 37 degrees C, the rate of renin release into the incubation medium in vitamin E-deficient group was significantly higher than that in the control group. krebs 48-53 renin Rattus norvegicus 122-127 6664459-15 1983 These results suggest that: (1) the increase in mean arterial pressure and drinking behaviour, induced by intraventricular injection of angiotensin II, are partially mediated via acetylcholine in brain, acting through muscarinic receptors; (2) decrease in heart rate induced by angiotensin II is not baroreceptor reflex-mediated; (3) the brain renin-angiotensin system does not participate in the cardiovascular and behavioural effect induced by cholinergic stimulation in the brain. Acetylcholine 179-192 renin Rattus norvegicus 344-349 6366185-6 1983 These findings indicate that vitamin E-deficiency specifically stimulates renin release from kidney cortical slices and this effect is attenuated by the dietary supplementation of TOCA or DPPD. N,N'-diphenyl-4-phenylenediamine 188-192 renin Rattus norvegicus 74-79 6366185-3 1983 When kidney cortical slices were incubated in a Krebs-Ringers" bicarbonate solution (pH 7.4) at 37 degrees C, the rate of renin release into the incubation medium in vitamin E-deficient group was significantly higher than that in the control group. Bicarbonates 63-74 renin Rattus norvegicus 122-127 6357573-0 1983 Trifluoperazine antagonizes inhibition of renin release by angiotensin II. Trifluoperazine 0-15 renin Rattus norvegicus 42-47 6360695-0 1983 Renin-angiotensin system and prostacyclin biosynthesis in streptozotocin diabetic rats. Streptozocin 58-72 renin Rattus norvegicus 0-5 6360695-1 1983 The relationship between the renin-angiotensin system (RAS) and prostacyclin (PGI2) biosynthesis was studied in experimental diabetic rats. Epoprostenol 64-76 renin Rattus norvegicus 29-34 6360695-1 1983 The relationship between the renin-angiotensin system (RAS) and prostacyclin (PGI2) biosynthesis was studied in experimental diabetic rats. Epoprostenol 78-82 renin Rattus norvegicus 29-34 6360695-3 1983 showed prolonged hypertension, and plasma renin activity decreased markedly from 8.4 +/- 0.7 to 2.4 +/- 0.3 and 1.2 +/- 0.3 ng angiotensin I/ml per h at 2 and 8 weeks after STZ treatment. Streptozocin 173-176 renin Rattus norvegicus 42-47 6358461-0 1983 Renin dependence of captopril-induced drinking after ureteric ligation in the rat. Captopril 20-29 renin Rattus norvegicus 0-5 6358461-6 1983 Captopril caused further increases in plasma renin concentration and more drinking suggesting that the captopril response is renin-dependent. Captopril 0-9 renin Rattus norvegicus 45-50 6358461-6 1983 Captopril caused further increases in plasma renin concentration and more drinking suggesting that the captopril response is renin-dependent. Captopril 0-9 renin Rattus norvegicus 125-130 6358461-6 1983 Captopril caused further increases in plasma renin concentration and more drinking suggesting that the captopril response is renin-dependent. Captopril 103-112 renin Rattus norvegicus 45-50 6358461-6 1983 Captopril caused further increases in plasma renin concentration and more drinking suggesting that the captopril response is renin-dependent. Captopril 103-112 renin Rattus norvegicus 125-130 6358461-13 1983 The same intracranial dose of captopril also inhibited drinking in response to intracranial injections of renin or angiotensin I, but not angiotensin II. Captopril 30-39 renin Rattus norvegicus 106-111 6358461-15 1983 In conclusion, subcutaneous captopril causes increased water intake through activation of the renal renin-angiotensin system, an effect that is enhanced when the system has already been partly activated by ureteric ligation. Captopril 28-37 renin Rattus norvegicus 100-105 6358461-15 1983 In conclusion, subcutaneous captopril causes increased water intake through activation of the renal renin-angiotensin system, an effect that is enhanced when the system has already been partly activated by ureteric ligation. Water 55-60 renin Rattus norvegicus 100-105 6358462-2 1983 In isolated perfused kidneys trifluoperazine stimulated basal renin secretion in a dose-dependent manner, with 10 microM causing no stimulation and 50 microM causing 167% increase. Trifluoperazine 29-44 renin Rattus norvegicus 62-67 6358462-3 1983 Trifluoperazine potentiated the elevated renin secretion induced by isoprenaline and low Ca in isolated kidneys. Trifluoperazine 0-15 renin Rattus norvegicus 41-46 6358462-3 1983 Trifluoperazine potentiated the elevated renin secretion induced by isoprenaline and low Ca in isolated kidneys. Isoproterenol 68-80 renin Rattus norvegicus 41-46 6358462-4 1983 In renal cortical cells trifluoperazine increased basal renin secretion and potentiated the secretion induced by Ca omission. Trifluoperazine 24-39 renin Rattus norvegicus 56-61 6358462-5 1983 Cells homogenized immediately after 1 h exposure to trifluoperazine had a substantial reduction in soluble renin without any effect on the change in granular renin. Trifluoperazine 52-67 renin Rattus norvegicus 107-112 6358462-7 1983 It is concluded that trifluoperazine stimulates renin secretion by a cellular mechanism possibly at the level of the juxtaglomerular cell. Trifluoperazine 21-36 renin Rattus norvegicus 48-53 6358462-8 1983 It is suggested that the role of trifluoperazine, and by inference calmodulin, in the secretion of renin may be quite different from its role in secretion of several other substances. Trifluoperazine 33-48 renin Rattus norvegicus 99-104 6368017-0 1983 Molecular characterization of renin in plasma and kidney of sodium-restricted rats. Sodium 60-66 renin Rattus norvegicus 30-35 6355549-1 1983 1) Renin-like enzyme of rat aorta was purified by chromatography with DEAE-cellulose and Sephadex G-200. DEAE-Cellulose 70-84 renin Rattus norvegicus 3-8 6355549-1 1983 1) Renin-like enzyme of rat aorta was purified by chromatography with DEAE-cellulose and Sephadex G-200. sephadex 89-103 renin Rattus norvegicus 3-8 6355549-2 1983 2) The molecular weight of renin-like enzyme was 124,000 and 72,000 on Sephadex G-200 gel filtration. sephadex 71-85 renin Rattus norvegicus 27-32 6416723-16 1983 Progressive 1 ml haemorrhages (to total blood loss of 4 ml, 1.3% body weight) resulted in similar increases in plasma renin activity in controls and (DMI + 6-OHDA)-treated animals but the response was significantly attenuated in 6-OHDA-treated rats. Oxidopamine 156-162 renin Rattus norvegicus 118-123 6357573-1 1983 The influence of trifluoperazine (TFP) treatment on angiotensin II-induced inhibition of renin release from the rat isolated perfused kidney was examined. Trifluoperazine 17-32 renin Rattus norvegicus 89-94 6311736-6 1983 Serum angiotensin-converting enzyme activity (SACE) and plasma arginine vasopressin (AVP) concentration were significantly higher (p less than 0.001 and 0.05, respectively), in the ICV captopril group than in the ICV vehicle group, while plasma aldosterone concentration and renin activity, fluid intake, urine volume, and urinary sodium excretion were similar in the two groups. Captopril 185-194 renin Rattus norvegicus 275-280 6311736-9 1983 Renin activity was elevated in the telencephalon of ICV captopril-treated animals but unaltered in the other brain regions examined. Captopril 56-65 renin Rattus norvegicus 0-5 6413405-1 1983 Previous studies from our laboratory have shown that chronic intracerebroventricular administration of captopril attenuates the development of hypertension in the spontaneously hypertensive rat of the Okamoto strain (SHR) without altering sodium and water balance, plasma renin, or sympathoadrenal activities. Captopril 103-112 renin Rattus norvegicus 272-277 6357573-2 1983 Angiotensin II, 1 mumol/l, in the presence of 1 mmol/l calcium, reduced basal renin secretion by 70%. Calcium 55-62 renin Rattus norvegicus 78-83 6357573-3 1983 When calcium was omitted from the perfusion medium, inhibition of renin release no longer occurred. Calcium 5-12 renin Rattus norvegicus 66-71 6357573-4 1983 Pretreatment of the rat isolated perfused kidney with the calmodulin inhibitor trifluoperazine (TFP), 10 mumol/l for 6 min, interfered with the inhibitory action of angiotensin II on renin release as well as angiotensin II-induced renal vasoconstriction. Trifluoperazine 79-94 renin Rattus norvegicus 183-188 6357573-4 1983 Pretreatment of the rat isolated perfused kidney with the calmodulin inhibitor trifluoperazine (TFP), 10 mumol/l for 6 min, interfered with the inhibitory action of angiotensin II on renin release as well as angiotensin II-induced renal vasoconstriction. Trifluoperazine 96-99 renin Rattus norvegicus 183-188 6352478-3 1983 Elevation of aortic renin was still present at 6 hours, and this was associated with significant blood pressure elevation (p less than 0.05) which could be reversed by infusion of sarcosine, alanine, angiotensin II (saralasin). Sarcosine 180-189 renin Rattus norvegicus 20-25 6658140-7 1983 The relationship between the renin-AII system and the central nervous system catecholamines could be involved in the control of development and maintenance of the renal arterial hypertension. Catecholamines 77-91 renin Rattus norvegicus 29-34 6352478-3 1983 Elevation of aortic renin was still present at 6 hours, and this was associated with significant blood pressure elevation (p less than 0.05) which could be reversed by infusion of sarcosine, alanine, angiotensin II (saralasin). Alanine 191-198 renin Rattus norvegicus 20-25 6356172-1 1983 Subcutaneous administration of l-5-hydroxytryptophan (5-HTP), the precursor of serotonin, to female rats induces copious drinking accompanied by activation of the renin-angiotensin system. 5-Hydroxytryptophan 31-52 renin Rattus norvegicus 163-168 6356172-1 1983 Subcutaneous administration of l-5-hydroxytryptophan (5-HTP), the precursor of serotonin, to female rats induces copious drinking accompanied by activation of the renin-angiotensin system. 5-Hydroxytryptophan 54-59 renin Rattus norvegicus 163-168 6356172-1 1983 Subcutaneous administration of l-5-hydroxytryptophan (5-HTP), the precursor of serotonin, to female rats induces copious drinking accompanied by activation of the renin-angiotensin system. Serotonin 79-88 renin Rattus norvegicus 163-168 6356172-3 1983 The objective of the present study was to determine whether serotonin-induced dipsogenesis, like that of 5-HTP, is mediated via the renin-angiotensin system. Serotonin 60-69 renin Rattus norvegicus 132-137 6356172-6 1983 The alpha 2-adrenergic agonist, clonidine (6.25 micrograms/kg, SC), which suppresses renin release from the kidney, attenuated serotonin-induced water intake. Clonidine 32-41 renin Rattus norvegicus 85-90 6356172-6 1983 The alpha 2-adrenergic agonist, clonidine (6.25 micrograms/kg, SC), which suppresses renin release from the kidney, attenuated serotonin-induced water intake. Serotonin 127-136 renin Rattus norvegicus 85-90 6415327-0 1983 Renin release and lipid peroxidation by ascorbic acid in the renin granule fraction of rat kidney cortex. Ascorbic Acid 40-53 renin Rattus norvegicus 0-5 6356172-6 1983 The alpha 2-adrenergic agonist, clonidine (6.25 micrograms/kg, SC), which suppresses renin release from the kidney, attenuated serotonin-induced water intake. Water 145-150 renin Rattus norvegicus 85-90 6356172-10 1983 These data indicate that serotonin induces drinking in rats via the renin-angiotensin system. Serotonin 25-34 renin Rattus norvegicus 68-73 6356172-11 1983 However, the results of the studies using methysergide suggest that serotonin appears to act at a point prior to activation of beta-adrenoceptors in the pathway leading to release of renin from the kidneys. Serotonin 68-77 renin Rattus norvegicus 183-188 6323152-2 1983 In normal and sham-operated rats, intracerebroventricular injection of dopamine resulted in a significant suppression of plasma renin activity and plasma aldosterone at 30 min, and intracerebroventricular injection of metoclopramide resulted in a significant elevation of plasma renin activity and plasma aldosterone at 30 min without altering the plasma corticosterone and potassium levels. Dopamine 71-79 renin Rattus norvegicus 128-133 6323152-2 1983 In normal and sham-operated rats, intracerebroventricular injection of dopamine resulted in a significant suppression of plasma renin activity and plasma aldosterone at 30 min, and intracerebroventricular injection of metoclopramide resulted in a significant elevation of plasma renin activity and plasma aldosterone at 30 min without altering the plasma corticosterone and potassium levels. Dopamine 71-79 renin Rattus norvegicus 279-284 6323152-2 1983 In normal and sham-operated rats, intracerebroventricular injection of dopamine resulted in a significant suppression of plasma renin activity and plasma aldosterone at 30 min, and intracerebroventricular injection of metoclopramide resulted in a significant elevation of plasma renin activity and plasma aldosterone at 30 min without altering the plasma corticosterone and potassium levels. Metoclopramide 218-232 renin Rattus norvegicus 279-284 6348199-3 1983 Control sodium-deprived rats showed increased plasma renin activities, increased peripheral aldosterone concentrations and reduced urinary sodium excretion; they maintained positive sodium balance and the zona glomerulosa of the adrenal cortex hypertrophied. Sodium 8-14 renin Rattus norvegicus 53-58 6352282-0 1983 Different effects of compound 48/80 and histamine on plasma renin activity. Histamine 40-49 renin Rattus norvegicus 60-65 6352282-3 1983 The compound 48/80-induced water intake seems to be mainly mediated by stimulation of the renin-angiotensin system. Water 27-32 renin Rattus norvegicus 90-95 6342908-11 1983 Based on these results, it is suggested that suppression of the kallikrein-kinin and prostaglandin systems, in addition to involvement of the renin-angiotensin system, is one of the factors contributing to the hypertensive action of dexamethasone. Dexamethasone 233-246 renin Rattus norvegicus 142-147 6307647-0 1983 Evidence that beta 1-adrenoceptor activation mediates isoproterenol-stimulated renin secretion in the rat. Isoproterenol 54-67 renin Rattus norvegicus 79-84 6307647-1 1983 The goal of these experiments was to determine if isoproterenol-stimulated renin secretion in the rat is mediated by activation of beta 1- and/or beta 2-adrenoceptors. Isoproterenol 50-63 renin Rattus norvegicus 75-80 6307647-3 1983 The renin secretory rate was a sigmoid function of the logarithm of the isoproterenol concentration; half-maximal and maximal stimulation occurred at approximately 0.01 and 0.1 microM isoproterenol, respectively. Isoproterenol 72-85 renin Rattus norvegicus 4-9 6307647-3 1983 The renin secretory rate was a sigmoid function of the logarithm of the isoproterenol concentration; half-maximal and maximal stimulation occurred at approximately 0.01 and 0.1 microM isoproterenol, respectively. Isoproterenol 184-197 renin Rattus norvegicus 4-9 6307647-7 1983 If it is assumed that timolol antagonizes both beta 1- and beta 2-adrenoceptors and that atenolol antagonizes only beta 1-adrenoceptors, it follows that isoproterenol-stimulated renin secretion in this preparation is mediated by activation of beta 1-adrenoceptors. Atenolol 89-97 renin Rattus norvegicus 178-183 6307647-7 1983 If it is assumed that timolol antagonizes both beta 1- and beta 2-adrenoceptors and that atenolol antagonizes only beta 1-adrenoceptors, it follows that isoproterenol-stimulated renin secretion in this preparation is mediated by activation of beta 1-adrenoceptors. Isoproterenol 153-166 renin Rattus norvegicus 178-183 6353423-0 1983 Role of renin release in the hemodynamic, renal and dipsogenic actions of the prostacyclin analogue CG 4203 in conscious rats. Epoprostenol 78-90 renin Rattus norvegicus 8-13 6353423-0 1983 Role of renin release in the hemodynamic, renal and dipsogenic actions of the prostacyclin analogue CG 4203 in conscious rats. cysteinylglycine 100-102 renin Rattus norvegicus 8-13 6353423-2 1983 CG 4203 infused intravenously starting at 1 microgram X kg-1 X min-1 induced both a fall in blood pressure and an increase of plasma renin activity. cysteinylglycine 0-2 renin Rattus norvegicus 133-138 6353423-7 1983 In conclusion, it is demonstrated that CG 4203 like prostacyclin itself already at hypotensive threshold dosages stimulates a functionally relevant renin release. cysteinylglycine 39-41 renin Rattus norvegicus 148-153 6353423-7 1983 In conclusion, it is demonstrated that CG 4203 like prostacyclin itself already at hypotensive threshold dosages stimulates a functionally relevant renin release. Epoprostenol 52-64 renin Rattus norvegicus 148-153 6353423-8 1983 The activation of the renin-angiotensin-aldosterone system attenuates the intrinsic hypotensive effects of CG 4203. the antidiuretic and dipsogenic efficacy of CG 4203 can also be attributed to renin-dependent angiotensin II formation. cysteinylglycine 107-109 renin Rattus norvegicus 22-27 6353423-8 1983 The activation of the renin-angiotensin-aldosterone system attenuates the intrinsic hypotensive effects of CG 4203. the antidiuretic and dipsogenic efficacy of CG 4203 can also be attributed to renin-dependent angiotensin II formation. cysteinylglycine 107-109 renin Rattus norvegicus 194-199 6353423-8 1983 The activation of the renin-angiotensin-aldosterone system attenuates the intrinsic hypotensive effects of CG 4203. the antidiuretic and dipsogenic efficacy of CG 4203 can also be attributed to renin-dependent angiotensin II formation. cysteinylglycine 160-162 renin Rattus norvegicus 22-27 6353423-8 1983 The activation of the renin-angiotensin-aldosterone system attenuates the intrinsic hypotensive effects of CG 4203. the antidiuretic and dipsogenic efficacy of CG 4203 can also be attributed to renin-dependent angiotensin II formation. cysteinylglycine 160-162 renin Rattus norvegicus 194-199 6138007-6 1983 Indenolol and propranolol markedly lowered the plasma renin activity (PRA) in SHR, RHR and DHR. indenolol 0-9 renin Rattus norvegicus 54-59 6138007-6 1983 Indenolol and propranolol markedly lowered the plasma renin activity (PRA) in SHR, RHR and DHR. Propranolol 14-25 renin Rattus norvegicus 54-59 6345375-6 1983 Treatment of spontaneously hypertensive rats (SHR) with nifedipine in food (315 parts per million) for 60 weeks prevented the development of hypertension and resulted in decreased plasma renin activity and plasma aldosterone concentration in comparison to untreated SHR controls. Nifedipine 56-66 renin Rattus norvegicus 187-192 6345375-8 1983 Results suggest that the antihypertensive action of calcium antagonists, at least those of the dihydropyridine type, is not only due to peripheral vasodilation, since in contrast to other vasodilators a hyperdynamic circulation is not induced, the renin-angiotensin-aldosterone system is not activated, and sodium/volume retention cannot be expected because of a primary natriuretic effect. Calcium 52-59 renin Rattus norvegicus 248-253 6415327-0 1983 Renin release and lipid peroxidation by ascorbic acid in the renin granule fraction of rat kidney cortex. Ascorbic Acid 40-53 renin Rattus norvegicus 61-66 6415327-2 1983 Ascorbic acid was used to cause lipid peroxidation in the renin granule fraction prepared from rat kidney cortex homogenate. Ascorbic Acid 0-13 renin Rattus norvegicus 58-63 6415327-4 1983 Ascorbic acid, at the concentrations from 5 to 100 microM, produced a dose-dependent increase in lipid peroxidation during incubation of the renin granule fraction at 37 degrees C for 30 min, accompanied by increased release of renin from the granules. Ascorbic Acid 0-13 renin Rattus norvegicus 141-146 6415327-4 1983 Ascorbic acid, at the concentrations from 5 to 100 microM, produced a dose-dependent increase in lipid peroxidation during incubation of the renin granule fraction at 37 degrees C for 30 min, accompanied by increased release of renin from the granules. Ascorbic Acid 0-13 renin Rattus norvegicus 228-233 6415327-6 1983 The simultaneous increases in lipid peroxidation and renin release induced by ascorbic acid in the renin granule fraction were markedly suppressed by the addition of disodium ethylenediaminetetra-acetic acid and antioxidants such as N,N"-diphenyl-p-phenylenediamine and hydroquinone. Ascorbic Acid 78-91 renin Rattus norvegicus 53-58 6415327-6 1983 The simultaneous increases in lipid peroxidation and renin release induced by ascorbic acid in the renin granule fraction were markedly suppressed by the addition of disodium ethylenediaminetetra-acetic acid and antioxidants such as N,N"-diphenyl-p-phenylenediamine and hydroquinone. Ascorbic Acid 78-91 renin Rattus norvegicus 99-104 6310235-2 1983 The administration of 19-OH-A-dione to the rats caused sodium retention and the 19-OH-A-dione treated rats developed high blood pressure, suppressed plasma renin activity and low plasma aldosterone, corticosterone and deoxycorticosterone concentrations. 19-oh-a-dione 22-35 renin Rattus norvegicus 156-161 6415327-6 1983 The simultaneous increases in lipid peroxidation and renin release induced by ascorbic acid in the renin granule fraction were markedly suppressed by the addition of disodium ethylenediaminetetra-acetic acid and antioxidants such as N,N"-diphenyl-p-phenylenediamine and hydroquinone. Edetic Acid 166-207 renin Rattus norvegicus 53-58 6310235-2 1983 The administration of 19-OH-A-dione to the rats caused sodium retention and the 19-OH-A-dione treated rats developed high blood pressure, suppressed plasma renin activity and low plasma aldosterone, corticosterone and deoxycorticosterone concentrations. 19-oh-a-dione 80-93 renin Rattus norvegicus 156-161 6358580-0 1983 Inhibition of captopril-induced increase in plasma renin activity by propranolol. Captopril 14-23 renin Rattus norvegicus 51-56 6358580-0 1983 Inhibition of captopril-induced increase in plasma renin activity by propranolol. Propranolol 69-80 renin Rattus norvegicus 51-56 6415327-6 1983 The simultaneous increases in lipid peroxidation and renin release induced by ascorbic acid in the renin granule fraction were markedly suppressed by the addition of disodium ethylenediaminetetra-acetic acid and antioxidants such as N,N"-diphenyl-p-phenylenediamine and hydroquinone. Edetic Acid 166-207 renin Rattus norvegicus 99-104 6358580-4 1983 First, the effect of propranolol on captopril-induced renin release was examined in conscious rats. Propranolol 21-32 renin Rattus norvegicus 54-59 6358580-4 1983 First, the effect of propranolol on captopril-induced renin release was examined in conscious rats. Captopril 36-45 renin Rattus norvegicus 54-59 6415327-6 1983 The simultaneous increases in lipid peroxidation and renin release induced by ascorbic acid in the renin granule fraction were markedly suppressed by the addition of disodium ethylenediaminetetra-acetic acid and antioxidants such as N,N"-diphenyl-p-phenylenediamine and hydroquinone. N,N'-diphenyl-4-phenylenediamine 233-265 renin Rattus norvegicus 53-58 6358580-5 1983 Secondly, the effect of AII on isoproterenol-induced renin release was determined. Isoproterenol 31-44 renin Rattus norvegicus 53-58 6415327-6 1983 The simultaneous increases in lipid peroxidation and renin release induced by ascorbic acid in the renin granule fraction were markedly suppressed by the addition of disodium ethylenediaminetetra-acetic acid and antioxidants such as N,N"-diphenyl-p-phenylenediamine and hydroquinone. N,N'-diphenyl-4-phenylenediamine 233-265 renin Rattus norvegicus 99-104 6358580-6 1983 Captopril (1 mg/Kg) increased plasma renin activity (PRA) from 1.6 +/- 0.3 ng/ml/hr to 4.5 +/- 0.6 ng/ml/hr (p less than 0.01). Captopril 0-9 renin Rattus norvegicus 37-42 6415327-6 1983 The simultaneous increases in lipid peroxidation and renin release induced by ascorbic acid in the renin granule fraction were markedly suppressed by the addition of disodium ethylenediaminetetra-acetic acid and antioxidants such as N,N"-diphenyl-p-phenylenediamine and hydroquinone. hydroquinone 270-282 renin Rattus norvegicus 53-58 6415327-6 1983 The simultaneous increases in lipid peroxidation and renin release induced by ascorbic acid in the renin granule fraction were markedly suppressed by the addition of disodium ethylenediaminetetra-acetic acid and antioxidants such as N,N"-diphenyl-p-phenylenediamine and hydroquinone. hydroquinone 270-282 renin Rattus norvegicus 99-104 6353042-7 1983 Isoproterenol stimulated the release of renin but not kallikrein. Isoproterenol 0-13 renin Rattus norvegicus 40-45 6344331-2 1983 Relative to time controls (TC), rats chronically exposed to 500 ppm lead in drinking water had significantly elevated basal plasma renin concentrations (PRC) (Pb = 12.0 +/- 1.6 ng/ml/hr, TC = 7.6 +/- 0.8). Water 85-90 renin Rattus norvegicus 131-136 6353042-8 1983 Stopping the oxygen supply to the perfusate suppressed kallikrein secretion in urine and renin release in the perfusate. Oxygen 13-19 renin Rattus norvegicus 89-94 6309534-9 1983 These results support the hypotheses that the renin-angiotensin system participates in the stimulation of drinking by isoproterenol and that the enhancement of drinking caused by inhibition of CE only in the circulation is the result of increased synthesis of angiotensin II in the brain. Isoproterenol 118-131 renin Rattus norvegicus 46-51 6344331-6 1983 Renal renin concentrations were significantly elevated in the 500 ppm rats (Pb = 1426 +/- 110 micrograms/kidney, TC = 1065 +/- 118) consistent with an increased basal renin secretion, but were not elevated in the 1000-ppm rats. Lead 76-78 renin Rattus norvegicus 6-11 6344331-6 1983 Renal renin concentrations were significantly elevated in the 500 ppm rats (Pb = 1426 +/- 110 micrograms/kidney, TC = 1065 +/- 118) consistent with an increased basal renin secretion, but were not elevated in the 1000-ppm rats. Technetium 113-115 renin Rattus norvegicus 6-11 6195492-3 1983 When osmolality of dextran-sucrose gradients was increased, some separation was found but both renin granules and mitochondria gained density. Dextrans 19-26 renin Rattus norvegicus 95-100 6397514-2 1983 However, the administration of DOCA and salt suppressed plasma renin activity (PRA), the renal renin content (RRC) of the clipped kidney and the response to a single oral dose of captopril (10 mg/kg). Desoxycorticosterone Acetate 31-35 renin Rattus norvegicus 63-68 6397514-2 1983 However, the administration of DOCA and salt suppressed plasma renin activity (PRA), the renal renin content (RRC) of the clipped kidney and the response to a single oral dose of captopril (10 mg/kg). Desoxycorticosterone Acetate 31-35 renin Rattus norvegicus 95-100 6397514-2 1983 However, the administration of DOCA and salt suppressed plasma renin activity (PRA), the renal renin content (RRC) of the clipped kidney and the response to a single oral dose of captopril (10 mg/kg). Salts 40-44 renin Rattus norvegicus 63-68 6397514-2 1983 However, the administration of DOCA and salt suppressed plasma renin activity (PRA), the renal renin content (RRC) of the clipped kidney and the response to a single oral dose of captopril (10 mg/kg). Salts 40-44 renin Rattus norvegicus 95-100 6195492-3 1983 When osmolality of dextran-sucrose gradients was increased, some separation was found but both renin granules and mitochondria gained density. Sucrose 27-34 renin Rattus norvegicus 95-100 6195492-4 1983 During a short centrifugation (4640 X g, 30 min) renin granules remained intact and appeared in two populations in Percoll-sucrose gradients. Sucrose 123-130 renin Rattus norvegicus 49-54 6195492-10 1983 In the animals kept on a low-sodium diet, both types of renin granules were increased. Sodium 29-35 renin Rattus norvegicus 56-61 6351125-7 1983 Serum renin activity was unaffected by nisoldipine but was elevated by cortisone treatment: nisoldipine increased aldosterone levels, but not when cortisone was also given. Nisoldipine 39-50 renin Rattus norvegicus 6-11 6339210-9 1983 Reduction of mean perfusion pressure to 50 mm Hg or adding isoproterenol to the perfusate produced much smaller increases in renin secretion by kidneys of hypophysectomized rats than that observed in kidneys from intact rats. Isoproterenol 59-72 renin Rattus norvegicus 125-130 6351125-7 1983 Serum renin activity was unaffected by nisoldipine but was elevated by cortisone treatment: nisoldipine increased aldosterone levels, but not when cortisone was also given. Cortisone 71-80 renin Rattus norvegicus 6-11 6351125-7 1983 Serum renin activity was unaffected by nisoldipine but was elevated by cortisone treatment: nisoldipine increased aldosterone levels, but not when cortisone was also given. Nisoldipine 92-103 renin Rattus norvegicus 6-11 6351125-7 1983 Serum renin activity was unaffected by nisoldipine but was elevated by cortisone treatment: nisoldipine increased aldosterone levels, but not when cortisone was also given. Aldosterone 114-125 renin Rattus norvegicus 6-11 6303178-0 1983 Effect of chloride on renin and blood pressure responses to sodium chloride. Chlorides 10-18 renin Rattus norvegicus 22-27 6303178-1 1983 Both the inhibition of renin release by sodium chloride and salt-sensitive hypertension have been attributed to sodium. Sodium Chloride 40-55 renin Rattus norvegicus 23-28 6303178-1 1983 Both the inhibition of renin release by sodium chloride and salt-sensitive hypertension have been attributed to sodium. Sodium 40-46 renin Rattus norvegicus 23-28 6303178-3 1983 In the Sprague-Dawley rat, acute and chronic administration of sodium salts other than sodium chloride failed to suppress plasma renin activity, whereas renin was inhibited by both sodium chloride and by selective chloride (without sodium) loading. Sodium Chloride 181-196 renin Rattus norvegicus 153-158 6303178-4 1983 Plasma renin activity was stimulated by selective chloride depletion. Chlorides 50-58 renin Rattus norvegicus 7-12 6303178-7 1983 Thus, both the renin and possibly the blood pressure responses to sodium chloride are dependent on chloride. Chlorides 73-81 renin Rattus norvegicus 15-20 6187563-4 1983 The threshold concentration for renin release in the calcium-containing medium was 50 microM for W-7, 5 microM for triflupromazine and 2 microM for trifluoperazine respectively. Calcium 53-60 renin Rattus norvegicus 32-37 6187563-4 1983 The threshold concentration for renin release in the calcium-containing medium was 50 microM for W-7, 5 microM for triflupromazine and 2 microM for trifluoperazine respectively. W 7 97-100 renin Rattus norvegicus 32-37 6187563-4 1983 The threshold concentration for renin release in the calcium-containing medium was 50 microM for W-7, 5 microM for triflupromazine and 2 microM for trifluoperazine respectively. Triflupromazine 115-130 renin Rattus norvegicus 32-37 6187563-4 1983 The threshold concentration for renin release in the calcium-containing medium was 50 microM for W-7, 5 microM for triflupromazine and 2 microM for trifluoperazine respectively. Trifluoperazine 148-163 renin Rattus norvegicus 32-37 6187563-6 1983 The maximum levels of renin release by the three antagonists were similar in both calcium-containing and calcium-free media. Calcium 82-89 renin Rattus norvegicus 22-27 6339210-11 1983 Kidneys from hormone-treated hypophysectomized rats also exhibited a greater renin secretory response to low perfusion pressure or isoproterenol. Isoproterenol 131-144 renin Rattus norvegicus 77-82 6187563-6 1983 The maximum levels of renin release by the three antagonists were similar in both calcium-containing and calcium-free media. Calcium 105-112 renin Rattus norvegicus 22-27 6341542-6 1983 This potent and specific stimulation of sodium intake by oral treatment with an inhibitor of the renin-angiotensin system may be caused by a paradoxical increase in the synthesis of angiotensin II in the brain. Sodium 40-46 renin Rattus norvegicus 97-102 6187563-7 1983 In the absence of these antagonists, the basal rate of renin release in the calcium-free medium was markedly higher than in the calcium-containing medium. Calcium 76-83 renin Rattus norvegicus 55-60 6187563-7 1983 In the absence of these antagonists, the basal rate of renin release in the calcium-free medium was markedly higher than in the calcium-containing medium. Calcium 128-135 renin Rattus norvegicus 55-60 6187563-8 1983 These results suggest that the calcium-calmodulin system inhibits renin release and that renin release is regulated by a mechanism different from the calcium-stimulated exocytotic mechanism by which many hormones are released. Calcium 31-38 renin Rattus norvegicus 66-71 6341543-6 1983 In the animals receiving prazosin, plasma renin activity was 4 times (P less than .001) and plasma vasopressin 7 times (P less than .01) higher than in the controls. Prazosin 25-33 renin Rattus norvegicus 42-47 6341543-11 1983 These data demonstrate that both the sympathetic and the renin angiotensin system are markedly stimulated by prazosin; they both appear to limit its acute hypotensive action. Prazosin 109-117 renin Rattus norvegicus 57-62 6342328-4 1983 Metoclopramide induced a dose-related increase in plasma aldosterone, whereas it only increased plasma renin activity at high doses (20 and 50 mg/kg). Metoclopramide 0-14 renin Rattus norvegicus 103-108 6343909-1 1983 The effect of vasoactive intestinal peptide (VIP) and isoproterenol on renin release in vitro was investigated using an isolated superfused rat glomerular preparation. Isoproterenol 54-67 renin Rattus norvegicus 71-76 6348254-6 1983 A single preoptic injection of less than 0.75 pmol (26.5 ng) purified mouse renin caused mean intakes of 250.4 +/- 26.2 ml water and 44.8 +/- 12.5 ml 2.7% NaCl by five naive rats in 24 h. After the largest dose (265 ng) intakes of water and 2.7% NaCl reached about 80% and 20% body weight respectively.4. Sodium Chloride 155-159 renin Rattus norvegicus 76-81 6345938-2 1983 A high dose (4 mg.kg-1) of the protein synthesis inhibitor, cyclohexamide, halved the rise in plasma renin level (with no change in renal cortex renin level and a fall in mean arterial pressure). 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione 60-73 renin Rattus norvegicus 101-106 6348254-0 1983 Renin-induced sodium appetite: effects on sodium balance and mediation by angiotensin in the rat. Sodium 14-20 renin Rattus norvegicus 0-5 6348254-6 1983 A single preoptic injection of less than 0.75 pmol (26.5 ng) purified mouse renin caused mean intakes of 250.4 +/- 26.2 ml water and 44.8 +/- 12.5 ml 2.7% NaCl by five naive rats in 24 h. After the largest dose (265 ng) intakes of water and 2.7% NaCl reached about 80% and 20% body weight respectively.4. Water 231-236 renin Rattus norvegicus 76-81 6187220-3 1983 Plasma renin activity (PRA) was increased by furosemide and also by the low-sodium diet. Furosemide 45-55 renin Rattus norvegicus 7-12 6348254-6 1983 A single preoptic injection of less than 0.75 pmol (26.5 ng) purified mouse renin caused mean intakes of 250.4 +/- 26.2 ml water and 44.8 +/- 12.5 ml 2.7% NaCl by five naive rats in 24 h. After the largest dose (265 ng) intakes of water and 2.7% NaCl reached about 80% and 20% body weight respectively.4. 2.7% nacl 150-159 renin Rattus norvegicus 76-81 6348254-7 1983 Weekly injections of renin resulted in progressively larger intakes of NaCl and water in response to the injections.5. Sodium Chloride 71-75 renin Rattus norvegicus 21-26 6348254-7 1983 Weekly injections of renin resulted in progressively larger intakes of NaCl and water in response to the injections.5. Water 80-85 renin Rattus norvegicus 21-26 6348254-11 1983 Preoptic injection of renin caused some increase in sodium excretion but this was small compared with the stimulating effect on sodium appetite.7. Sodium 52-58 renin Rattus norvegicus 22-27 6348254-13 1983 Increased intakes of water and 2.7% NaCl caused by renin resulted in the rats going into and remaining in positive fluid and sodium balance throughout the 24 h experiment.8. Water 21-26 renin Rattus norvegicus 51-56 6348254-13 1983 Increased intakes of water and 2.7% NaCl caused by renin resulted in the rats going into and remaining in positive fluid and sodium balance throughout the 24 h experiment.8. Sodium Chloride 36-40 renin Rattus norvegicus 51-56 6348254-13 1983 Increased intakes of water and 2.7% NaCl caused by renin resulted in the rats going into and remaining in positive fluid and sodium balance throughout the 24 h experiment.8. Sodium 125-131 renin Rattus norvegicus 51-56 6348254-14 1983 Renin-induced sodium appetite and thirst were inhibited by the converting enzyme inhibitors teprotide or captopril, or by the angiotensin antagonist saralasin. Teprotide 92-101 renin Rattus norvegicus 0-5 6348254-14 1983 Renin-induced sodium appetite and thirst were inhibited by the converting enzyme inhibitors teprotide or captopril, or by the angiotensin antagonist saralasin. Captopril 105-114 renin Rattus norvegicus 0-5 6348254-14 1983 Renin-induced sodium appetite and thirst were inhibited by the converting enzyme inhibitors teprotide or captopril, or by the angiotensin antagonist saralasin. Saralasin 149-158 renin Rattus norvegicus 0-5 6348254-17 1983 In conclusion, renin injected into the preoptic region or third ventricle is a potent stimulus to sodium appetite as well as thirst. Sodium 98-104 renin Rattus norvegicus 15-20 6348254-0 1983 Renin-induced sodium appetite: effects on sodium balance and mediation by angiotensin in the rat. Sodium 42-48 renin Rattus norvegicus 0-5 6348254-4 1983 The stimulating effect of renin on intake of water and hypertonic (2.7%) NaCl was continuous and persisted for at least a week after the largest (265 ng) dose of purified renin.3. Water 45-50 renin Rattus norvegicus 26-31 6348254-4 1983 The stimulating effect of renin on intake of water and hypertonic (2.7%) NaCl was continuous and persisted for at least a week after the largest (265 ng) dose of purified renin.3. Sodium Chloride 73-77 renin Rattus norvegicus 26-31 6348254-6 1983 A single preoptic injection of less than 0.75 pmol (26.5 ng) purified mouse renin caused mean intakes of 250.4 +/- 26.2 ml water and 44.8 +/- 12.5 ml 2.7% NaCl by five naive rats in 24 h. After the largest dose (265 ng) intakes of water and 2.7% NaCl reached about 80% and 20% body weight respectively.4. Water 123-128 renin Rattus norvegicus 76-81 6299044-3 1983 There was a positive correlation of both active renin and MAP with serum calcium at this time. Calcium 73-80 renin Rattus norvegicus 48-53 6187220-3 1983 Plasma renin activity (PRA) was increased by furosemide and also by the low-sodium diet. Sodium 76-82 renin Rattus norvegicus 7-12 6187220-6 1983 These results suggest that furosemide and low-sodium diet act on the kidney to release renin via protease production. Furosemide 27-37 renin Rattus norvegicus 87-92 6187220-6 1983 These results suggest that furosemide and low-sodium diet act on the kidney to release renin via protease production. Sodium 46-52 renin Rattus norvegicus 87-92 6187220-7 1983 Because SBTI affected neither PRA nor urinary kallikrein excretion stimulated by these sodium depletions, it is suggested that renal kallikrein may play an important role in the control of renin release stimulated by furosemide and by low-sodium diet. Furosemide 217-227 renin Rattus norvegicus 189-194 6337046-0 1983 Comparison of the effects of rubidium and potassium on renin secretion from rat kidney slices. Rubidium 29-37 renin Rattus norvegicus 55-60 6337739-7 1983 Direct infusion of renin in rats treated with captopril resulted in further suppression of the angiotensinogen release rate, compared with those given captopril alone. Captopril 46-55 renin Rattus norvegicus 19-24 6337739-7 1983 Direct infusion of renin in rats treated with captopril resulted in further suppression of the angiotensinogen release rate, compared with those given captopril alone. Captopril 151-160 renin Rattus norvegicus 19-24 6337046-0 1983 Comparison of the effects of rubidium and potassium on renin secretion from rat kidney slices. Potassium 42-51 renin Rattus norvegicus 55-60 6337046-3 1983 Adding either KCl or RbCl to a nominally K-free incubation medium stimulated renin secretory rate in concentration-dependent manners; secretory rate was half-maximally stimulated at approximately 1.5 mM and maximally stimulated at approximately 2-3 mM concentrations of either KCl or RbCl. Potassium Chloride 14-17 renin Rattus norvegicus 77-82 6337046-3 1983 Adding either KCl or RbCl to a nominally K-free incubation medium stimulated renin secretory rate in concentration-dependent manners; secretory rate was half-maximally stimulated at approximately 1.5 mM and maximally stimulated at approximately 2-3 mM concentrations of either KCl or RbCl. rubidium chloride 21-25 renin Rattus norvegicus 77-82 6337960-2 1983 We have previously suggested that inhibition of renin release by sodium chloride is related to absorptive chloride transport in the loop of Henle. Sodium Chloride 65-80 renin Rattus norvegicus 48-53 6337046-3 1983 Adding either KCl or RbCl to a nominally K-free incubation medium stimulated renin secretory rate in concentration-dependent manners; secretory rate was half-maximally stimulated at approximately 1.5 mM and maximally stimulated at approximately 2-3 mM concentrations of either KCl or RbCl. Potassium Chloride 277-280 renin Rattus norvegicus 77-82 6337960-2 1983 We have previously suggested that inhibition of renin release by sodium chloride is related to absorptive chloride transport in the loop of Henle. Chlorides 72-80 renin Rattus norvegicus 48-53 6337046-3 1983 Adding either KCl or RbCl to a nominally K-free incubation medium stimulated renin secretory rate in concentration-dependent manners; secretory rate was half-maximally stimulated at approximately 1.5 mM and maximally stimulated at approximately 2-3 mM concentrations of either KCl or RbCl. rubidium chloride 284-288 renin Rattus norvegicus 77-82 6337960-3 1983 Infusion of sodium chloride fails to inhibit renin release in the adrenalectomized (Adx) rat, and dexamethasone restores renin responsiveness to sodium chloride. Dexamethasone 98-111 renin Rattus norvegicus 121-126 6337046-6 1983 Renin secretory rate was greatly inhibited by incubating kidney slices in media containing 60 mM concentrations of either KCl or RbCl. Potassium Chloride 122-125 renin Rattus norvegicus 0-5 6337960-3 1983 Infusion of sodium chloride fails to inhibit renin release in the adrenalectomized (Adx) rat, and dexamethasone restores renin responsiveness to sodium chloride. Sodium Chloride 145-160 renin Rattus norvegicus 121-126 6188888-4 1983 Plasma renin concentration (PRC) prior to the administration of captopril was highest in the furosemide group, followed by the HCTZ, TCTZ, and control groups, in this order. Captopril 64-73 renin Rattus norvegicus 7-12 6337046-6 1983 Renin secretory rate was greatly inhibited by incubating kidney slices in media containing 60 mM concentrations of either KCl or RbCl. rubidium chloride 129-133 renin Rattus norvegicus 0-5 6188888-4 1983 Plasma renin concentration (PRC) prior to the administration of captopril was highest in the furosemide group, followed by the HCTZ, TCTZ, and control groups, in this order. Furosemide 93-103 renin Rattus norvegicus 7-12 6337046-8 1983 Taken together with previous results, these observations suggest that Rb can substitute for K in the renin secretory process. Rubidium 70-72 renin Rattus norvegicus 101-106 6188888-6 1983 These data suggest that repeated administration of diuretics renders the maintenance of blood pressure more dependent on the renin-angiotensin system without affecting blood pressure and that this situation underlies the potentiation of the antihypertensive action of captopril by combined use of diuretics. Captopril 268-277 renin Rattus norvegicus 125-130 6337511-6 1983 Plasma renin activity tended to increase as the length of the water-deprivation period increased. Water 62-67 renin Rattus norvegicus 7-12 6340406-0 1983 Circulatory effects of renin-angiotensin system antagonists during halothane anaesthesia in hypertensive rats. Halothane 67-76 renin Rattus norvegicus 23-28 6340406-9 1983 During halothane anaesthesia, the plasma renin activities in the captopril, captopril + indomethacin, and saralasin groups were significantly higher than in untreated animals. Halothane 7-16 renin Rattus norvegicus 41-46 6340406-9 1983 During halothane anaesthesia, the plasma renin activities in the captopril, captopril + indomethacin, and saralasin groups were significantly higher than in untreated animals. Captopril 65-74 renin Rattus norvegicus 41-46 6340406-9 1983 During halothane anaesthesia, the plasma renin activities in the captopril, captopril + indomethacin, and saralasin groups were significantly higher than in untreated animals. Captopril 76-85 renin Rattus norvegicus 41-46 6340406-9 1983 During halothane anaesthesia, the plasma renin activities in the captopril, captopril + indomethacin, and saralasin groups were significantly higher than in untreated animals. Indomethacin 88-100 renin Rattus norvegicus 41-46 6340406-9 1983 During halothane anaesthesia, the plasma renin activities in the captopril, captopril + indomethacin, and saralasin groups were significantly higher than in untreated animals. Saralasin 106-115 renin Rattus norvegicus 41-46 6340406-11 1983 The results suggest that the renin-angiotensin system is important in maintaining blood pressure in halothane anaesthesia, and that the tolerance to haemorrhagic shock is particularly impaired by drugs inhibiting the renin-angiotensin system. Halothane 100-109 renin Rattus norvegicus 29-34 6342005-5 1983 ASA or naloxone pretreatments significantly lowered the captopril hypotensive effect, thus suggesting an involvement of prostaglandin and opioid systems in blood pressure elevation in "non renin dependent" hypertension. Aspirin 0-3 renin Rattus norvegicus 189-194 6340406-11 1983 The results suggest that the renin-angiotensin system is important in maintaining blood pressure in halothane anaesthesia, and that the tolerance to haemorrhagic shock is particularly impaired by drugs inhibiting the renin-angiotensin system. Halothane 100-109 renin Rattus norvegicus 217-222 6337027-3 1983 These results suggest that the reduction of blood pressure in two-kidney, one-clip hypertensive rats may be due to reduced renin release through the action of clonidine, while in one-kidney, one-clip hypertensive rats the sympathetic nervous activity may play little or no role in the maintenance of high blood pressure. Clonidine 159-168 renin Rattus norvegicus 123-128 6342005-5 1983 ASA or naloxone pretreatments significantly lowered the captopril hypotensive effect, thus suggesting an involvement of prostaglandin and opioid systems in blood pressure elevation in "non renin dependent" hypertension. Naloxone 7-15 renin Rattus norvegicus 189-194 6337313-0 1983 Antihypertensive effects of I-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine on plasma renin activity and catecholamine responses in spontaneously hypertensive rats. i-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine 28-76 renin Rattus norvegicus 87-92 6339119-2 1983 The administration of 6 beta-OH-A-dione to rats with the adrenals caused sodium-retention as the administration of 19-OH-A-dione did and the 6 beta-OH-A-dione treated rats developed high blood pressure, suppressed plasma renin activity and low plasma aldosterone, corticosterone and 11-deoxycorticosterone concentrations as the 19-OH-A-dione treated rats did. beta-oh-a-dione 24-39 renin Rattus norvegicus 221-226 6139189-1 1983 In the isolated perfused rat kidney renin release is increased by physiological agents which stimulate adenylate cyclase activity, such as beta-adrenoceptor agonists, prostaglandins, histamine (histamine H2-receptor mediated) and adenosine (adenosine RA-receptor mediated). Prostaglandins 167-181 renin Rattus norvegicus 36-41 6139189-1 1983 In the isolated perfused rat kidney renin release is increased by physiological agents which stimulate adenylate cyclase activity, such as beta-adrenoceptor agonists, prostaglandins, histamine (histamine H2-receptor mediated) and adenosine (adenosine RA-receptor mediated). Histamine 183-192 renin Rattus norvegicus 36-41 6339119-2 1983 The administration of 6 beta-OH-A-dione to rats with the adrenals caused sodium-retention as the administration of 19-OH-A-dione did and the 6 beta-OH-A-dione treated rats developed high blood pressure, suppressed plasma renin activity and low plasma aldosterone, corticosterone and 11-deoxycorticosterone concentrations as the 19-OH-A-dione treated rats did. beta-oh-a-dione 143-158 renin Rattus norvegicus 221-226 6139189-2 1983 The role of adenylate cyclase and cAMP in the stimulatory pathway for renin release was confirmed by the effect of forskolin, a receptor-independent stimulator of adenylate cyclase, which also stimulated renin release. Cyclic AMP 34-38 renin Rattus norvegicus 70-75 6315270-1 1983 Evidence has accumulated that systemic administration of converting enzyme inhibitors (CEI) such as captopril, MK 421 or SA 446 not only produces an inhibition of the plasma renin angiotensin system (RAS), but also of the RAS in various target organs which are relevant for blood pressure (BP) regulation. Captopril 100-109 renin Rattus norvegicus 174-179 6139189-2 1983 The role of adenylate cyclase and cAMP in the stimulatory pathway for renin release was confirmed by the effect of forskolin, a receptor-independent stimulator of adenylate cyclase, which also stimulated renin release. Colforsin 115-124 renin Rattus norvegicus 70-75 6315270-1 1983 Evidence has accumulated that systemic administration of converting enzyme inhibitors (CEI) such as captopril, MK 421 or SA 446 not only produces an inhibition of the plasma renin angiotensin system (RAS), but also of the RAS in various target organs which are relevant for blood pressure (BP) regulation. Enalapril 111-117 renin Rattus norvegicus 174-179 6340860-5 1983 However, following administration of isoproterenol at doses of 5, 10, or 20 micrograms/kg body weight, s.c., plasma renin activity was elevated significantly (p less than 0.01) in the normotensive, but only in the lowest dose in the renal hypertensive group. Isoproterenol 37-50 renin Rattus norvegicus 116-121 6315270-1 1983 Evidence has accumulated that systemic administration of converting enzyme inhibitors (CEI) such as captopril, MK 421 or SA 446 not only produces an inhibition of the plasma renin angiotensin system (RAS), but also of the RAS in various target organs which are relevant for blood pressure (BP) regulation. rentiapril 121-127 renin Rattus norvegicus 174-179 6139189-2 1983 The role of adenylate cyclase and cAMP in the stimulatory pathway for renin release was confirmed by the effect of forskolin, a receptor-independent stimulator of adenylate cyclase, which also stimulated renin release. Colforsin 115-124 renin Rattus norvegicus 204-209 6139189-4 1983 This conclusion is based on the observation that various inhibitors of calmodulin stimulated renin release and that the calcium-dependent inhibition of renin release by angiotensin II was abolished in the presence of these inhibitors. Calcium 120-127 renin Rattus norvegicus 152-157 6131777-6 1983 Renin concentration and activity increased after pentobarbital anesthesia, while only renin activity was increased during ether anesthesia. Pentobarbital 49-62 renin Rattus norvegicus 0-5 6640969-2 1983 Effects of adrenalectomy and selective treatment with either aldosterone (30 micrograms/kg/day) or dexamethasone (60 micrograms/kg/day) on plasma renin substrate, active renin (PRA), total renin and blood pressure were studied in 10 week old SHR and control WKY rats. Aldosterone 61-72 renin Rattus norvegicus 146-151 6640969-2 1983 Effects of adrenalectomy and selective treatment with either aldosterone (30 micrograms/kg/day) or dexamethasone (60 micrograms/kg/day) on plasma renin substrate, active renin (PRA), total renin and blood pressure were studied in 10 week old SHR and control WKY rats. Dexamethasone 99-112 renin Rattus norvegicus 146-151 6640969-7 1983 Both PRA and total renin were higher (p less than 0.01) in the adrenalectomized, saline repleted state. Sodium Chloride 81-87 renin Rattus norvegicus 19-24 6640969-9 1983 However, dexamethasone inhibited the adrenalectomy associated increase of PRA and total renin in SHR but not in WKY rats. Dexamethasone 9-22 renin Rattus norvegicus 88-93 6357559-7 1983 Plasma and aortic renin were altered by bilateral nephrectomy and modulation of salt intake. Salts 80-84 renin Rattus norvegicus 18-23 6131777-6 1983 Renin concentration and activity increased after pentobarbital anesthesia, while only renin activity was increased during ether anesthesia. Ether 122-127 renin Rattus norvegicus 86-91 6186863-0 1983 Inhibitory effect of circulating norepinephrine on epinephrine-induced renin secretion. Norepinephrine 33-47 renin Rattus norvegicus 71-76 6186863-0 1983 Inhibitory effect of circulating norepinephrine on epinephrine-induced renin secretion. Epinephrine 36-47 renin Rattus norvegicus 71-76 6186863-1 1983 The potential role of circulating catecholamines in the regulation of plasma renin concentration (PRC) was evaluated in conscious rats. Catecholamines 34-48 renin Rattus norvegicus 77-82 6186863-5 1983 It is concluded that, in the rat, the circulating catecholamines contribute to the control of PRC by modulating renin secretion through stimulation-inhibition mechanisms. Catecholamines 50-64 renin Rattus norvegicus 112-117 6316431-0 1983 Potentiation of beta-adrenergic affects on plasma renin concentration by pentobarbital anesthesia. Pentobarbital 73-86 renin Rattus norvegicus 50-55 6336784-0 1983 Effects of trifluoperazine on renin secretion of rat kidney slices. Trifluoperazine 11-26 renin Rattus norvegicus 30-35 6336784-3 1983 The purpose of these experiments was to determine the effects of trifluoperazine, an inactivator of Ca-calmodulin, on renin secretion of rat kidney slices. Trifluoperazine 65-80 renin Rattus norvegicus 118-123 6336784-4 1983 Over the range 10(-6) to 10(-4) M, trifluoperazine produced a concentration-dependent increase in renin release. Trifluoperazine 35-50 renin Rattus norvegicus 98-103 6336784-5 1983 As assessed by lactate dehydrogenase release, the trifluoperazine-induced increase in renin release cannot be attributed to increased cell membrane permeability to proteins. Trifluoperazine 50-65 renin Rattus norvegicus 86-91 6336784-6 1983 Thus, trifluoperazine stimulated renin secretion in a concentration-dependent manner. Trifluoperazine 6-21 renin Rattus norvegicus 33-38 6336784-8 1983 However, in the presence of trifluoperazine, isoproterenol still stimulated and antidiuretic hormone, angiotensin II, high extracellular K concentration, ouabain and vanadate still inhibited renin secretion. Trifluoperazine 28-43 renin Rattus norvegicus 191-196 6336784-8 1983 However, in the presence of trifluoperazine, isoproterenol still stimulated and antidiuretic hormone, angiotensin II, high extracellular K concentration, ouabain and vanadate still inhibited renin secretion. Vanadates 166-174 renin Rattus norvegicus 191-196 6336784-10 1983 It is concluded that trifluoperazine-stimulated renin secretion is mediated by a decrease in Cai produced by inhibition of Ca influx and/or stimulation of Ca efflux and/or sequestration. Trifluoperazine 21-36 renin Rattus norvegicus 48-53 6338501-2 1983 All Pb-exposed groups sacrificed by decapitation had elevated mean plasma renin activities (PRA), relative to controls. Lead 4-6 renin Rattus norvegicus 74-79 6338501-6 1983 We conclude that exposure of rats in utero and during lactation to doses of Pb which produce blood Pb concentrations similar to those generally present in human populations stimulates basal renin secretion in 1-month-old rats, but partially inhibits the response to renin-releasing stimuli. Lead 76-78 renin Rattus norvegicus 266-271 6361937-0 1983 The effect of metoclopramide and haloperidol on plasma renin activity and aldosterone levels in rats. Metoclopramide 14-28 renin Rattus norvegicus 55-60 6361937-0 1983 The effect of metoclopramide and haloperidol on plasma renin activity and aldosterone levels in rats. Haloperidol 33-44 renin Rattus norvegicus 55-60 6316431-6 1983 These results are consistent with the view that the renin response to pentobarbital anesthesia is somehow related to the vascular effects of the anesthetic. Pentobarbital 70-83 renin Rattus norvegicus 52-57 6756166-0 1982 Prostaglandin in renin release during sodium deprivation. Prostaglandins 0-13 renin Rattus norvegicus 17-22 6756166-0 1982 Prostaglandin in renin release during sodium deprivation. Sodium 38-44 renin Rattus norvegicus 17-22 6756166-1 1982 This study was designed to examine the role of prostaglandins in the macula densa-mediated increase in plasma renin activity (PRA) during dietary sodium deprivation in rats. Prostaglandins 47-61 renin Rattus norvegicus 110-115 6756166-1 1982 This study was designed to examine the role of prostaglandins in the macula densa-mediated increase in plasma renin activity (PRA) during dietary sodium deprivation in rats. Sodium 146-152 renin Rattus norvegicus 110-115 6756170-3 1982 Independent manipulation of the mean arterial pressure or plasma renin activity by pretreatment with reserpine or deoxycorticosterone before surgery shows that the presence or absence of paralysis is dependent on the plasma renin activity and not on the high blood pressure. Reserpine 101-110 renin Rattus norvegicus 65-70 6756170-3 1982 Independent manipulation of the mean arterial pressure or plasma renin activity by pretreatment with reserpine or deoxycorticosterone before surgery shows that the presence or absence of paralysis is dependent on the plasma renin activity and not on the high blood pressure. Desoxycorticosterone 114-133 renin Rattus norvegicus 65-70 6763912-0 1982 Renal denervation in rats: effects of intravenous infusions of norepinephrine on plasma renin activity & renal excretory functions. Norepinephrine 63-77 renin Rattus norvegicus 88-93 6763895-0 1982 Effect of the catecholestrogen 2-hydroxyestradiol on the renin-angiotensin system in the rat. 2-hydroxyestradiol 31-49 renin Rattus norvegicus 57-62 6763895-1 1982 The effects of the catecholestrogen 2-hydroxyestradiol (250 and 500 micrograms/day, each for 7 days) on plasma renin substrate (PRS), activity (PRA) and concentration (PRC) were studied in male rats as compared with those of estradiol (250 micrograms/day, for 7 days) and vehicle alone (for 7 days). Estradiol 45-54 renin Rattus norvegicus 111-116 6763077-3 1982 Renin granules were prepared from the kidney cortex homogenate by a discontinuous sucrose density gradient centrifugation. Sucrose 82-89 renin Rattus norvegicus 0-5 6763077-5 1982 The intake of vitamin E-deficient diet for 4 weeks resulted in a decrease in alpha-tocopherol content in renin granules, accompanied by an increased level of endogenous lipid peroxides. Vitamin E 14-23 renin Rattus norvegicus 105-110 6763077-5 1982 The intake of vitamin E-deficient diet for 4 weeks resulted in a decrease in alpha-tocopherol content in renin granules, accompanied by an increased level of endogenous lipid peroxides. alpha-Tocopherol 77-93 renin Rattus norvegicus 105-110 6763077-6 1982 When the renin granules were incubated at 37 degrees C, the rate of renin release from the granules in vitamin E-deficient group was significantly higher than that in the control group. Vitamin E 103-112 renin Rattus norvegicus 9-14 6763077-6 1982 When the renin granules were incubated at 37 degrees C, the rate of renin release from the granules in vitamin E-deficient group was significantly higher than that in the control group. Vitamin E 103-112 renin Rattus norvegicus 68-73 6763077-7 1982 These results indicate that vitamin E exists in renin granule membranes and functions in maintenance of membrane integrity by blocking the lipid peroxidation. Vitamin E 28-37 renin Rattus norvegicus 48-53 6753605-1 1982 Rat renal cortical slices incubated in vitro released 7.0 +/- 0.5% (mean +/- SE, n=30) of their total renin content into the incubation medium in 1 h. Isoproterenol (10-6 M), a beta-adrenergic agonist, caused a 75 +/- 17% (n=7) increase in renin release from the cortical slices. Isoproterenol 151-164 renin Rattus norvegicus 102-107 6753605-3 1982 After protein synthesis and presumably renin synthesis was blocked with either cycloheximide or puromycin, isoproterenol was still able to increase significantly renin release from the cortical slices despite almost total blockade of protein synthesis. Isoproterenol 107-120 renin Rattus norvegicus 162-167 6753605-4 1982 We conclude that a storage pool of renin content is released may exist, since 1) only 7.0 +/- 0.5% of the cortical slice renin content is released each hour, and 2) isoproterenol stimulation of renin release is not acutely dependent on renin synthesis. Isoproterenol 165-178 renin Rattus norvegicus 35-40 6762803-0 1982 Intraventricular injections of renin increase amine turnover in the tuberoinfundibular dopamine neurons and reduce the secretion of prolactin in the male rat. Amines 46-51 renin Rattus norvegicus 31-36 6762803-0 1982 Intraventricular injections of renin increase amine turnover in the tuberoinfundibular dopamine neurons and reduce the secretion of prolactin in the male rat. Dopamine 87-95 renin Rattus norvegicus 31-36 6290195-1 1982 The principal side effects of the drug carbenoxolone (Biogastrone; 18 beta-glycyrrhetinic acid sodium hemisuccinate) are sodium retention, hypokalemic alkalosis, suppressed plasma renin, and hypertension. Carbenoxolone 39-52 renin Rattus norvegicus 180-185 6757528-0 1982 The effect of water deprivation on the osmotic release of renin. Water 14-19 renin Rattus norvegicus 58-63 6762615-1 1982 The relationship between renin secretion and PGI2 production, in response to intrarenal infusion of norepinephrine, was examined in the isolated perfused rat kidney. Norepinephrine 100-114 renin Rattus norvegicus 25-30 6762615-2 1982 Infusion of norepinephrine in a dose which caused substantial vasoconstriction (100 ng/min), markedly increased urinary excretion of 6-keto PGF1 alpha, the stable derivative of PGI2, without significantly altering renin secretion measured in the effluent perfusate. Norepinephrine 12-26 renin Rattus norvegicus 214-219 6762615-6 1982 These findings clearly indicate that in the rat kidney prostacyclin production and renin release in response to norepinephrine are dissociated. Norepinephrine 112-126 renin Rattus norvegicus 83-88 6292084-0 1982 Central effects of prostaglandin E2 on blood pressure and plasma renin activity in rats. Dinoprostone 19-35 renin Rattus norvegicus 65-70 6292084-9 1982 The renin-stimulating effect of centrally administered PGE2 is, at least in part, dependent on beta-adrenergic receptor stimulation by increased circulating catecholamines. Dinoprostone 55-59 renin Rattus norvegicus 4-9 6292084-9 1982 The renin-stimulating effect of centrally administered PGE2 is, at least in part, dependent on beta-adrenergic receptor stimulation by increased circulating catecholamines. Catecholamines 157-171 renin Rattus norvegicus 4-9 6750082-9 1982 Nifedipine at 250, 500 and 750 nM significantly increased the renin secretion rate compared to that of untreated control kidneys. Nifedipine 0-10 renin Rattus norvegicus 62-67 6750082-10 1982 When renin secretion was enhanced by 50 nM isoproterenol, this stimulatory effect was enhanced in kidneys concomitantly treated with 500 and 750 nM nifedipine. Isoproterenol 43-56 renin Rattus norvegicus 5-10 6750082-10 1982 When renin secretion was enhanced by 50 nM isoproterenol, this stimulatory effect was enhanced in kidneys concomitantly treated with 500 and 750 nM nifedipine. Nifedipine 148-158 renin Rattus norvegicus 5-10 6750082-14 1982 These results suggest that: 1) both nifedipine and dihydralazine increase diuresis, natriuresis and kaliuresis in the isolated perfused rat kidney and 2) nifedipine enhances basal renin release from the juxta-glomerular cells and potentiates renin release caused by beta receptor stimulation. Nifedipine 36-46 renin Rattus norvegicus 180-185 6757528-1 1982 The effect of water deprivation on the osmotic release of renin was evaluated in conscious rats previously prepared with right nephrectomy and cannulations of left renal artery and lower abdominal aorta. Water 14-19 renin Rattus norvegicus 58-63 6750082-14 1982 These results suggest that: 1) both nifedipine and dihydralazine increase diuresis, natriuresis and kaliuresis in the isolated perfused rat kidney and 2) nifedipine enhances basal renin release from the juxta-glomerular cells and potentiates renin release caused by beta receptor stimulation. Nifedipine 36-46 renin Rattus norvegicus 242-247 6757528-6 1982 It is concluded that some intrarenal functional or structural change induced by water deprivation sensitizes the renin-secreting mechanism to colloid osmotic stimuli. Water 80-85 renin Rattus norvegicus 113-118 6750082-14 1982 These results suggest that: 1) both nifedipine and dihydralazine increase diuresis, natriuresis and kaliuresis in the isolated perfused rat kidney and 2) nifedipine enhances basal renin release from the juxta-glomerular cells and potentiates renin release caused by beta receptor stimulation. Dihydralazine 51-64 renin Rattus norvegicus 180-185 6750082-14 1982 These results suggest that: 1) both nifedipine and dihydralazine increase diuresis, natriuresis and kaliuresis in the isolated perfused rat kidney and 2) nifedipine enhances basal renin release from the juxta-glomerular cells and potentiates renin release caused by beta receptor stimulation. Dihydralazine 51-64 renin Rattus norvegicus 242-247 6810710-6 1982 When the rapid breakdown of PGI2 was counteracted by either increasing the concentration to 1.7 x 10(-4) M or stabilizing in Krebs at pH 9.4, it stimulated a significant increase in renin release. Epoprostenol 28-32 renin Rattus norvegicus 182-187 6750082-14 1982 These results suggest that: 1) both nifedipine and dihydralazine increase diuresis, natriuresis and kaliuresis in the isolated perfused rat kidney and 2) nifedipine enhances basal renin release from the juxta-glomerular cells and potentiates renin release caused by beta receptor stimulation. Nifedipine 154-164 renin Rattus norvegicus 180-185 6750082-14 1982 These results suggest that: 1) both nifedipine and dihydralazine increase diuresis, natriuresis and kaliuresis in the isolated perfused rat kidney and 2) nifedipine enhances basal renin release from the juxta-glomerular cells and potentiates renin release caused by beta receptor stimulation. Nifedipine 154-164 renin Rattus norvegicus 242-247 6289992-3 1982 We conclude that blood-borne angiotensin II induces vasopressin release by acting on the subfornical organ; depending on the dose of isoprenaline, activation of the endogenous renin-angiotensin system may mediate isoprenaline-induced vasopressin release. Isoproterenol 133-145 renin Rattus norvegicus 176-181 6289992-3 1982 We conclude that blood-borne angiotensin II induces vasopressin release by acting on the subfornical organ; depending on the dose of isoprenaline, activation of the endogenous renin-angiotensin system may mediate isoprenaline-induced vasopressin release. Isoproterenol 213-225 renin Rattus norvegicus 176-181 6810710-0 1982 Renin release selectively stimulated by prostaglandin I2 in isolated rat glomeruli. Epoprostenol 40-56 renin Rattus norvegicus 0-5 6810710-5 1982 Superfusion with 1.6 x 10(-4) M arachidonic acid stimulated a significant release of renin from glomeruli, whereas 2.7 x 10(-6) M PGE1, PGE2, PGF2 alpha, TXB2, PGD2, or a stable analog of PGH2 had no effect on renin. Arachidonic Acid 32-48 renin Rattus norvegicus 85-90 6810710-6 1982 When the rapid breakdown of PGI2 was counteracted by either increasing the concentration to 1.7 x 10(-4) M or stabilizing in Krebs at pH 9.4, it stimulated a significant increase in renin release. krebs 125-130 renin Rattus norvegicus 182-187 6810710-7 1982 Reducing the arachidonic acid concentration to 1.6 x 10(-5) M eliminated both renin release and PGI2 synthesis, while increased PGE2 synthesis persisted. Arachidonic Acid 13-29 renin Rattus norvegicus 78-83 6810710-8 1982 Finally, using an inhibitor of PGI2 synthesis, azo analog 1 (2.8 x 10(-6) M), 6-keto-PGF1 alpha produced in response to arachidonic acid was eliminated, as was the concurrent release of renin, but PGE2 synthesis was not affected. Epoprostenol 31-35 renin Rattus norvegicus 186-191 6810710-8 1982 Finally, using an inhibitor of PGI2 synthesis, azo analog 1 (2.8 x 10(-6) M), 6-keto-PGF1 alpha produced in response to arachidonic acid was eliminated, as was the concurrent release of renin, but PGE2 synthesis was not affected. anthrone 47-50 renin Rattus norvegicus 186-191 6810710-8 1982 Finally, using an inhibitor of PGI2 synthesis, azo analog 1 (2.8 x 10(-6) M), 6-keto-PGF1 alpha produced in response to arachidonic acid was eliminated, as was the concurrent release of renin, but PGE2 synthesis was not affected. Dinoprostone 197-201 renin Rattus norvegicus 186-191 6286283-4 1982 In the presence of isoproterenol (10(-6) M), renin secretion from the renal cortical slices was increased significantly (87%) over control (P less than 0.05). Isoproterenol 19-32 renin Rattus norvegicus 45-50 6286283-7 1982 It is hypothesized that isoproterenol stimulates the secretion of stored renin, which appears to be composed of a subset of the multiple renin forms. Isoproterenol 24-37 renin Rattus norvegicus 73-78 6286283-7 1982 It is hypothesized that isoproterenol stimulates the secretion of stored renin, which appears to be composed of a subset of the multiple renin forms. Isoproterenol 24-37 renin Rattus norvegicus 137-142 6810710-9 1982 These results suggest that the mechanism of direct interaction between renal PG and renin in isolated glomeruli is selectively due to the action of PGI2. Prostaglandins 77-79 renin Rattus norvegicus 84-89 6810710-9 1982 These results suggest that the mechanism of direct interaction between renal PG and renin in isolated glomeruli is selectively due to the action of PGI2. Epoprostenol 148-152 renin Rattus norvegicus 84-89 7051854-6 1982 Although a parallel disappearance of active and inactive renin is observed after bilateral nephrectomy of the pentobarbital-anesthetized animal, complete occlusion of the renal arteries and veins after ether-induced renin stimulation results in a significant increase of inactive renin. Ether 202-207 renin Rattus norvegicus 216-221 7049920-0 1982 Effect of colchicine on drug-induced changes in plasma renin concentration in rats. Colchicine 10-20 renin Rattus norvegicus 55-60 7049920-3 1982 The present studies were designed to determine: 1) if the antimicrotubule drug, colchicine, would alter plasma renin concentration (PRC); and 2) if changes in PRC could be related to an effect on cytoplasmic microtubules. Colchicine 80-90 renin Rattus norvegicus 111-116 7051854-6 1982 Although a parallel disappearance of active and inactive renin is observed after bilateral nephrectomy of the pentobarbital-anesthetized animal, complete occlusion of the renal arteries and veins after ether-induced renin stimulation results in a significant increase of inactive renin. Ether 202-207 renin Rattus norvegicus 216-221 6753070-0 1982 Cyclosporin A-induced increases in renin storage and release. Cyclosporine 0-13 renin Rattus norvegicus 35-40 6127427-0 1982 Chronic effects of bunitrolol and pindolol on blood pressure, heart rate, vascular lesions, and plasma renin activity in hypertensive rats. bunitrolol 19-29 renin Rattus norvegicus 103-108 6182339-5 1982 Sodium loading depressed plasma and kidney renin but did not alter intrarenal AII. Sodium 0-6 renin Rattus norvegicus 43-48 6753070-2 1982 Renin release from incubated renal cortical slices was increased in rats treated with 25 or 50 mg/kg/day of CyA for 3 to 7 days. Cyclosporine 108-111 renin Rattus norvegicus 0-5 24271992-7 1982 Plasma renin activity was significantly higher in Pb-exposed animals. Lead 50-52 renin Rattus norvegicus 7-12 6759392-11 1982 Finally, vascular renin is probably not renal in origin and responds to typical feedback inhibition as unmasked by captopril administration. Captopril 115-124 renin Rattus norvegicus 18-23 6287956-5 1982 In the rat, we observed the same drop of renin substrate during MK421 administration. Enalapril 64-69 renin Rattus norvegicus 41-46 7046471-1 1982 The role of the renin-angiotensin system in the regulation of the blood pressure of dexamethasone-treated rats (Dex) was evaluated using saralasin, an angiotensin II antagonist, and SQ 14225 (SQ) (d-3-mercapto-2-methylpropranoyl-1-proline), an angiotensin-converting enzyme inhibitor. Dexamethasone 84-97 renin Rattus norvegicus 16-21 7046471-1 1982 The role of the renin-angiotensin system in the regulation of the blood pressure of dexamethasone-treated rats (Dex) was evaluated using saralasin, an angiotensin II antagonist, and SQ 14225 (SQ) (d-3-mercapto-2-methylpropranoyl-1-proline), an angiotensin-converting enzyme inhibitor. dex 112-115 renin Rattus norvegicus 16-21 7046471-8 1982 These results indicate that the elevation of blood pressure in DEX depends partially on the renin-angiotensin system. Dextromethorphan 63-66 renin Rattus norvegicus 92-97 6889448-4 1982 Apparently, the inclusion of ethanol metabolites in the normal brain metabolism appreciably changes the role of angiotensin-II in hypothalamohypophyseal and renin-angiotensin system functions. Ethanol 29-36 renin Rattus norvegicus 157-162 6750551-0 1982 Changes in "active" and "inactive" renin in the juxtaglomerular apparatuses of rat nephrons and plasma induced by different salt intake. Salts 124-128 renin Rattus norvegicus 35-40 6750551-3 1982 In rats with low salt intake the renin content of superficial JGA was 13.4 +/- 3.0 ng AI/JGA/h before and 20.4 +/- 3.4 ng AI/JGA/h (n = 9), P less than 0.05) after acidification. Salts 17-21 renin Rattus norvegicus 33-38 6750551-7 1982 In rats with a normal salt intake the superficial renin JGA renin content was 11.6 +/- 2.3 ng AI/JGA/h before and 11.0 +/- 2.7 ng AI/JGA/h (n = 9, N.S.) Salts 22-26 renin Rattus norvegicus 50-55 6282372-0 1982 Relation of plasma renin activity to the antihypertensive effect of MK 421 in the rat. Enalapril 68-74 renin Rattus norvegicus 19-24 6750722-0 1982 Calcium and renin release: inhibition of low sodium-induced renin secretion by high calcium concentration in rat kidney perfusion. Sodium 45-51 renin Rattus norvegicus 12-17 6750722-0 1982 Calcium and renin release: inhibition of low sodium-induced renin secretion by high calcium concentration in rat kidney perfusion. Sodium 45-51 renin Rattus norvegicus 60-65 6750722-0 1982 Calcium and renin release: inhibition of low sodium-induced renin secretion by high calcium concentration in rat kidney perfusion. Calcium 84-91 renin Rattus norvegicus 12-17 6750722-0 1982 Calcium and renin release: inhibition of low sodium-induced renin secretion by high calcium concentration in rat kidney perfusion. Calcium 84-91 renin Rattus norvegicus 60-65 6750722-1 1982 The effects of changes in calcium on renin secretion have been studied in the isolated perfused rat kidney. Calcium 26-33 renin Rattus norvegicus 37-42 6750722-2 1982 Perfusion with free calcium buffer significantly decreases renin secretion as compared with control experiments (Ca++: 2.5 mM/l). Calcium 20-27 renin Rattus norvegicus 59-64 6750722-4 1982 When the renin release is previously increased by low sodium concentration (Na+: 110 mM/l) however, perfusion with high calcium buffer (Ca++: 5 mM/l) significantly inhibits this stimulation. Sodium 54-60 renin Rattus norvegicus 9-14 6750722-4 1982 When the renin release is previously increased by low sodium concentration (Na+: 110 mM/l) however, perfusion with high calcium buffer (Ca++: 5 mM/l) significantly inhibits this stimulation. Calcium 120-127 renin Rattus norvegicus 9-14 7044145-0 1982 Effects of acute potassium infusions with salts other than chloride on plasma renin activity. Potassium 17-26 renin Rattus norvegicus 78-83 7044145-1 1982 To evaluate the contribution of chloride to the suppression of plasma renin activity (PRA) by KCl, PRA was measured before and after venous infusions of KCl, KHCO3, KNO3, and KC2H3O2 in dietary NaCl-restricted rats. Chlorides 32-40 renin Rattus norvegicus 70-75 7044145-1 1982 To evaluate the contribution of chloride to the suppression of plasma renin activity (PRA) by KCl, PRA was measured before and after venous infusions of KCl, KHCO3, KNO3, and KC2H3O2 in dietary NaCl-restricted rats. Potassium Chloride 94-97 renin Rattus norvegicus 70-75 7046618-0 1982 Hyperplasia of juxtaglomerular cells and renin localization in kidney of normotensive animals given captopril. Captopril 100-109 renin Rattus norvegicus 41-46 7044138-9 1982 3) alpha-Casein-Sepharose column also separated neutral proteases and immunoreactive renin from acid protease capable of generating angiotensin. Sepharose 16-25 renin Rattus norvegicus 85-90 7038049-2 1982 The involvement of endopeptidase activity in the enzymatical cleavage of the renin substrate was inferred from the simultaneous accumulation of both angiotensin I and the complementary tetrapeptide Leu-Val-Tyr-Ser on incubation of tetradecapeptide with rat brain tissue. leu-val-tyr-ser 198-213 renin Rattus norvegicus 77-82 7040241-2 1982 Stimulation of active renin was accompanied by either an increase (low sodium diet), no change (pentobarbital anesthesia plus hemorrhage), or fall (pentobarbital anesthesia) in the plasma levels of inactive renin, while suppression of active renin was accompanied by a fall (high sodium diet) or mild but nonsignificant increases (clonidine or saline infusion) of the inactive enzyme. Sodium 71-77 renin Rattus norvegicus 22-27 7040241-2 1982 Stimulation of active renin was accompanied by either an increase (low sodium diet), no change (pentobarbital anesthesia plus hemorrhage), or fall (pentobarbital anesthesia) in the plasma levels of inactive renin, while suppression of active renin was accompanied by a fall (high sodium diet) or mild but nonsignificant increases (clonidine or saline infusion) of the inactive enzyme. Pentobarbital 96-109 renin Rattus norvegicus 22-27 7040241-2 1982 Stimulation of active renin was accompanied by either an increase (low sodium diet), no change (pentobarbital anesthesia plus hemorrhage), or fall (pentobarbital anesthesia) in the plasma levels of inactive renin, while suppression of active renin was accompanied by a fall (high sodium diet) or mild but nonsignificant increases (clonidine or saline infusion) of the inactive enzyme. Pentobarbital 148-161 renin Rattus norvegicus 22-27 7040241-2 1982 Stimulation of active renin was accompanied by either an increase (low sodium diet), no change (pentobarbital anesthesia plus hemorrhage), or fall (pentobarbital anesthesia) in the plasma levels of inactive renin, while suppression of active renin was accompanied by a fall (high sodium diet) or mild but nonsignificant increases (clonidine or saline infusion) of the inactive enzyme. Sodium 280-286 renin Rattus norvegicus 22-27 7040241-2 1982 Stimulation of active renin was accompanied by either an increase (low sodium diet), no change (pentobarbital anesthesia plus hemorrhage), or fall (pentobarbital anesthesia) in the plasma levels of inactive renin, while suppression of active renin was accompanied by a fall (high sodium diet) or mild but nonsignificant increases (clonidine or saline infusion) of the inactive enzyme. Clonidine 331-340 renin Rattus norvegicus 22-27 7040241-2 1982 Stimulation of active renin was accompanied by either an increase (low sodium diet), no change (pentobarbital anesthesia plus hemorrhage), or fall (pentobarbital anesthesia) in the plasma levels of inactive renin, while suppression of active renin was accompanied by a fall (high sodium diet) or mild but nonsignificant increases (clonidine or saline infusion) of the inactive enzyme. Sodium Chloride 344-350 renin Rattus norvegicus 22-27 6461704-3 1982 Renin depletion induced by DOCA-saline pretreatment was associated with protection against HgCl2-induced ARF only when the saline diuresis was maintained by drinking 1% NaCl after injury. Desoxycorticosterone Acetate 27-31 renin Rattus norvegicus 0-5 6461704-3 1982 Renin depletion induced by DOCA-saline pretreatment was associated with protection against HgCl2-induced ARF only when the saline diuresis was maintained by drinking 1% NaCl after injury. Sodium Chloride 32-38 renin Rattus norvegicus 0-5 6461704-3 1982 Renin depletion induced by DOCA-saline pretreatment was associated with protection against HgCl2-induced ARF only when the saline diuresis was maintained by drinking 1% NaCl after injury. Mercuric Chloride 91-96 renin Rattus norvegicus 0-5 6461704-3 1982 Renin depletion induced by DOCA-saline pretreatment was associated with protection against HgCl2-induced ARF only when the saline diuresis was maintained by drinking 1% NaCl after injury. Sodium Chloride 123-129 renin Rattus norvegicus 0-5 6461704-3 1982 Renin depletion induced by DOCA-saline pretreatment was associated with protection against HgCl2-induced ARF only when the saline diuresis was maintained by drinking 1% NaCl after injury. Sodium Chloride 169-173 renin Rattus norvegicus 0-5 6461704-5 1982 Continuous intravenous loading with saline and furosemide, although increasing renal renin levels, afforded as much protection as saline loading alone. Sodium Chloride 36-42 renin Rattus norvegicus 85-90 6461704-5 1982 Continuous intravenous loading with saline and furosemide, although increasing renal renin levels, afforded as much protection as saline loading alone. Furosemide 47-57 renin Rattus norvegicus 85-90 6461704-8 1982 Thus protection against HgCl2-induced ARF was independent of the renal renin level but closely related to urinary NaCl excretion after the injury. Mercuric Chloride 24-29 renin Rattus norvegicus 71-76 7042955-9 1982 injection of furosemide, by decreasing cardiac preload, mainly due to venodilation, reduces cardiac output of renin-dependent hypertensive animals, whereas mean arterial blood pressure and heart rate remain unaltered. Furosemide 13-23 renin Rattus norvegicus 110-115 6177994-0 1982 Isoproterenol-stimulated renin secretion in the rat: second messenger roles of Ca and cyclic AMP. Isoproterenol 0-13 renin Rattus norvegicus 25-30 6177994-3 1982 Agents which previously were shown to inhibit basal renin secretion by increasing Cai (ouabain, vanadate, angiotensin II, antidiuretic hormone, and 60 mM K) antagonized and/or blocked isoproterenol-stimulated secretion, which is thought to be mediated by adenylate cyclase activation and increased levels of c-AMP. Vanadates 96-104 renin Rattus norvegicus 52-57 6177994-3 1982 Agents which previously were shown to inhibit basal renin secretion by increasing Cai (ouabain, vanadate, angiotensin II, antidiuretic hormone, and 60 mM K) antagonized and/or blocked isoproterenol-stimulated secretion, which is thought to be mediated by adenylate cyclase activation and increased levels of c-AMP. Isoproterenol 184-197 renin Rattus norvegicus 52-57 6177994-10 1982 Further, they are consistent with the hypothesis that in isoproterenol-stimulated renin secretion. Isoproterenol 57-70 renin Rattus norvegicus 82-87 7040889-0 1982 Renin release by pentobarbital anesthesia in the rat: a role for vascular mechanisms. Pentobarbital 17-30 renin Rattus norvegicus 0-5 7047325-0 1982 [Pharmacological studies on azosemide [5-(4"-chloro-5"-sulfamoyl-2"-thenylamino)-phenyltetrazole], a new diuretic (1) Effects on diuresis, plasma renin activity and urinary prostaglandin E excretion in normal rats (author"s transl)]. azosemide 28-37 renin Rattus norvegicus 146-151 7040889-1 1982 Studies were undertaken in intact rats to characterize the renin response to pentobarbital anesthesia and the mechanisms involved in this response. Pentobarbital 77-90 renin Rattus norvegicus 59-64 6765221-1 1982 Data from previous experiments in rats indicate that release of serotonin in the central nervous system increases renin and corticosterone secretion. Serotonin 64-73 renin Rattus norvegicus 114-119 7040889-3 1982 A sustained 2-3-fold increase in plasma renin concentration (PRC) and a 10-15 mm Hg depression of mean arterial pressure were found in pentobarbital anesthesia. Pentobarbital 135-148 renin Rattus norvegicus 40-45 7040889-8 1982 We concluded that the renin response to pentobarbital anesthesia is unrelated to changes in sympatho-adrenal activity. Pentobarbital 40-53 renin Rattus norvegicus 22-27 7040889-10 1982 It is postulated that pentobarbital-induced relaxation of afferent arterioles or JG cells exposes previously concealed beta-receptor sites which increase the signal for the release of renin. Pentobarbital 22-35 renin Rattus norvegicus 184-189 6175808-1 1982 Acute hypovolemia induced by bleeding (5 ml/300 g body weight) halothane-anesthetized (0.8% in oxygen) rats is attended by hypotension, bradycardia, and increases in plasma renin, vasopressin, and catecholamine levels. Halothane 63-72 renin Rattus norvegicus 173-178 7037219-4 1982 Lowering the osmolality of the perfusate by reducing the concentration of sodium chloride also prevented the increase in renin secretion produced by perfusion with 11 g per 100 ml albumin. Sodium Chloride 74-89 renin Rattus norvegicus 121-126 7037219-5 1982 Increasing the osmolality of the perfusate with mannitol restored the augmented renin release. Mannitol 48-56 renin Rattus norvegicus 80-85 7040199-1 1982 The isoprenaline-induced renin release was used to study both in vivo and in vitro and mechanism of the inhibitory effect of vasopressin on renin secretion. Isoproterenol 4-16 renin Rattus norvegicus 25-30 7040199-1 1982 The isoprenaline-induced renin release was used to study both in vivo and in vitro and mechanism of the inhibitory effect of vasopressin on renin secretion. Isoproterenol 4-16 renin Rattus norvegicus 140-145 7040199-3 1982 In contrast, angiotensin II (10(-6) M) prevented the renin release in response to isoprenaline. Isoproterenol 82-94 renin Rattus norvegicus 53-58 6175369-5 1982 2 In a separate group of animals, noradrenaline infusion in this manner and at similar dose rate increased plasma renin activity approximately 3 fold. Norepinephrine 34-47 renin Rattus norvegicus 114-119 6175369-10 1982 5 These data show that the regulation of glomerular filtration rate in response to the vasoconstrictor drug, noradrenaline, is partly mediated via the renin-angiotensin system. Norepinephrine 109-122 renin Rattus norvegicus 151-156 6175808-1 1982 Acute hypovolemia induced by bleeding (5 ml/300 g body weight) halothane-anesthetized (0.8% in oxygen) rats is attended by hypotension, bradycardia, and increases in plasma renin, vasopressin, and catecholamine levels. Catecholamines 197-210 renin Rattus norvegicus 173-178 6175808-2 1982 Infusion of prostacyclin (PGI2, O.03 microgram/kg.min) to acutely hemorrhaged rats enhanced recuperation of heart rate, and potentiated the sympathetic response and vasopressin release without altering blood pressure of plasma renin concentration (PRC). Epoprostenol 12-24 renin Rattus norvegicus 227-232 6175808-2 1982 Infusion of prostacyclin (PGI2, O.03 microgram/kg.min) to acutely hemorrhaged rats enhanced recuperation of heart rate, and potentiated the sympathetic response and vasopressin release without altering blood pressure of plasma renin concentration (PRC). Epoprostenol 26-30 renin Rattus norvegicus 227-232 6175808-7 1982 Furthermore, prostacyclin may stimulate renin secretion in sufficient amount to compensate for the inadequate sympathetic response during hemorrhagic shock. Epoprostenol 13-25 renin Rattus norvegicus 40-45 7048455-0 1982 [Propranolol effect on renin-angiotensin system kinetics during experimental hyperthyroidism (author"s transl)]. Propranolol 1-12 renin Rattus norvegicus 23-28 6276536-0 1982 The renin-angiotensin system in aminoglycoside-induced acute renal failure. Aminoglycosides 32-46 renin Rattus norvegicus 4-9 7043093-2 1982 The 19-OH-A-dione treated rats developed high blood pressure, hypokalemia, suppressed plasma renin activity and low plasma aldosterone and corticosterone concentrations as the DOCA treated rats did. 19-oh-a-dione 4-17 renin Rattus norvegicus 93-98 7043495-0 1982 Evening primrose oil, a dietary prostaglandin precursor, diminishes vascular reactivity to renin and angiotensin II in rats. evening primrose oil 8-20 renin Rattus norvegicus 91-115 7043495-0 1982 Evening primrose oil, a dietary prostaglandin precursor, diminishes vascular reactivity to renin and angiotensin II in rats. Prostaglandins 32-45 renin Rattus norvegicus 91-115 7060565-8 1982 Kinetic constants measured for the release of angiotensin I by renin were found to be Km = 5.0 microM proangiotensin and V = 270 nmol of angiotensin I h-1 unit renin-1 for the concanavalin-A-binding form and Km = 5.6 microM proangiotensin and V = 250 nmol angiotensin I h-1 unit renin-1 for the prohormone which did not bind to concanavalin-A--Sepharose. Sepharose 344-353 renin Rattus norvegicus 63-68 7047719-0 1982 The effects of antidiuretic hormone and state of potassium balance on the renin-angiotensin system in rats with diabetes insipidus. Potassium 49-58 renin Rattus norvegicus 74-79 6295229-0 1982 Effect of lithium and antidiuretic hormone on plasma renin concentration in diabetes insipidus rats (Brattleboro rat model). Lithium 10-17 renin Rattus norvegicus 53-58 7047719-2 1982 The influence of ADH and the state of potassium balance on the renin-angiotensin system was studied in rats with hereditary diabetes insipidus (DI rats). Potassium 38-47 renin Rattus norvegicus 63-68 7047719-17 1982 Plasma renin concentration was significantly lower in ADH-treated than in untreated DI rats on a high potassium intake, suggesting that the inhibitory effects of ADH and potassium are additive. Potassium 102-111 renin Rattus norvegicus 7-12 7047719-17 1982 Plasma renin concentration was significantly lower in ADH-treated than in untreated DI rats on a high potassium intake, suggesting that the inhibitory effects of ADH and potassium are additive. Potassium 170-179 renin Rattus norvegicus 7-12 7036759-5 1982 These results suggest that drinking produced by chronic oral treatment of rats with captopril may be caused by the effects of the elevated ANG I concentrations achieved after blockade of ACE and stimulation of renin secretion by captopril. Captopril 84-93 renin Rattus norvegicus 210-215 7036759-5 1982 These results suggest that drinking produced by chronic oral treatment of rats with captopril may be caused by the effects of the elevated ANG I concentrations achieved after blockade of ACE and stimulation of renin secretion by captopril. Captopril 229-238 renin Rattus norvegicus 210-215 6763275-1 1982 In this study we have shown that sodium deprivation of rats increased the number of specific granules and renin activity in atria. Sodium 33-39 renin Rattus norvegicus 106-111 6763275-2 1982 Sodium loading and DOCA treatment were found to lower the number of granules and renin activity. Sodium 0-6 renin Rattus norvegicus 81-86 6763275-2 1982 Sodium loading and DOCA treatment were found to lower the number of granules and renin activity. Desoxycorticosterone Acetate 19-23 renin Rattus norvegicus 81-86 6758648-0 1982 The role of renin in the paradoxical antipolyuric effects of chlorothiazide in the homozygous Brattleboro rat. Chlorothiazide 61-75 renin Rattus norvegicus 12-17 6754147-3 1982 Infusions of 10 micrograms aldosterone/day into adrenalectomized (ADX)--SHR, Wistar Kyoto (WKY) and Sprague-Dawley (SD) rats completely suppressed plasma renin activity in all strains and lowered plasma potassium levels to below normal in WKY and SD rats; aldosterone treated SHR were normokalemic. Aldosterone 27-38 renin Rattus norvegicus 154-159 6284411-1 1982 Captopril (30 mg/kg/day orally for two days) in spontaneously hypertensive rats (SHR) inhibited serum angiotensin converting enzyme (ACE) activity 92.3%; increased plasma renin activity (PRA) 18-fold and reduced mean arterial blood pressure (MABP) 19 mm Hg. Captopril 0-9 renin Rattus norvegicus 171-176 6284411-6 1982 These results suggest that the potentiating effect of HCTZ is due to some mechanism that shifts the animal"s blood pressure maintenance system to a renin-dependent state and is not due to changes in vascular reactivity. Hydrochlorothiazide 54-58 renin Rattus norvegicus 148-153 6756681-0 1982 Secretion control for active and inactive renin: interactions with calcium and sodium ions. Calcium 67-74 renin Rattus norvegicus 42-47 7047003-7 1982 Captopril and HCTZ increased plasma renin activity (PRA) but only the combination of captopril and HCTZ produced a greater and longer lasting increase of PRA. Captopril 0-9 renin Rattus norvegicus 36-41 6756681-0 1982 Secretion control for active and inactive renin: interactions with calcium and sodium ions. Sodium 79-85 renin Rattus norvegicus 42-47 6756684-6 1982 On the other hand, high-molecular-weight renin (Mr:60,000) was formed when the extract of isolated tubular segments was mixed with the low-molecular-weight renin, in the presence of sodium tetrathionate. Tetrathionic Acid 182-202 renin Rattus norvegicus 41-46 6756693-3 1982 In the anesthetized rat intravenous captopril or sodium nitroprusside resulted in elevation of active renin only. Captopril 36-45 renin Rattus norvegicus 102-107 6756693-3 1982 In the anesthetized rat intravenous captopril or sodium nitroprusside resulted in elevation of active renin only. Nitroprusside 49-69 renin Rattus norvegicus 102-107 6756693-5 1982 Elevated levels of active and total renin were observed in anesthetized Wistar rats that had received oral captopril for a 6 week period. Captopril 107-116 renin Rattus norvegicus 36-41 6756695-2 1982 Sodium depletion increased total and active renin in the juxtaglomerular apparatus and approximately one third of the renin was in an inactive form in sodium depletion. Sodium 0-6 renin Rattus norvegicus 44-49 6756695-2 1982 Sodium depletion increased total and active renin in the juxtaglomerular apparatus and approximately one third of the renin was in an inactive form in sodium depletion. Sodium 151-157 renin Rattus norvegicus 118-123 6756695-3 1982 Sodium loading decreased active and total renin and there was no inactive renin present. Sodium 0-6 renin Rattus norvegicus 42-47 7047003-7 1982 Captopril and HCTZ increased plasma renin activity (PRA) but only the combination of captopril and HCTZ produced a greater and longer lasting increase of PRA. Hydrochlorothiazide 14-18 renin Rattus norvegicus 36-41 6756695-5 1982 Haemorrhage caused a release of active renin in both sodium states and did not alter the renin content of the J.G.A. Sodium 53-59 renin Rattus norvegicus 39-44 7047003-8 1982 It is concluded that the mechanism for the synergism is the renin dependency, created by the combination of HCTZ and captopril, resulting in a greater role of the renin system in blood pressure control and increased responsiveness to angiotensin converting enzyme inhibition by captopril. Hydrochlorothiazide 108-112 renin Rattus norvegicus 60-65 6756695-6 1982 Increased delivery of sodium chloride to the macula densa increased the active renin content of J.G.A. Sodium Chloride 22-37 renin Rattus norvegicus 79-84 7047003-8 1982 It is concluded that the mechanism for the synergism is the renin dependency, created by the combination of HCTZ and captopril, resulting in a greater role of the renin system in blood pressure control and increased responsiveness to angiotensin converting enzyme inhibition by captopril. Hydrochlorothiazide 108-112 renin Rattus norvegicus 163-168 7047003-8 1982 It is concluded that the mechanism for the synergism is the renin dependency, created by the combination of HCTZ and captopril, resulting in a greater role of the renin system in blood pressure control and increased responsiveness to angiotensin converting enzyme inhibition by captopril. Captopril 117-126 renin Rattus norvegicus 60-65 7047003-8 1982 It is concluded that the mechanism for the synergism is the renin dependency, created by the combination of HCTZ and captopril, resulting in a greater role of the renin system in blood pressure control and increased responsiveness to angiotensin converting enzyme inhibition by captopril. Captopril 117-126 renin Rattus norvegicus 163-168 7047003-8 1982 It is concluded that the mechanism for the synergism is the renin dependency, created by the combination of HCTZ and captopril, resulting in a greater role of the renin system in blood pressure control and increased responsiveness to angiotensin converting enzyme inhibition by captopril. Captopril 278-287 renin Rattus norvegicus 60-65 7047003-8 1982 It is concluded that the mechanism for the synergism is the renin dependency, created by the combination of HCTZ and captopril, resulting in a greater role of the renin system in blood pressure control and increased responsiveness to angiotensin converting enzyme inhibition by captopril. Captopril 278-287 renin Rattus norvegicus 163-168 6278351-0 1982 Acute changes in cyclic AMP levels of certain brain areas following intraventricular injection of renin in rats. Cyclic AMP 17-27 renin Rattus norvegicus 98-103 7043299-1 1982 The effect of the serotonin-releasing drug parachloroamphetamine (PCA) on plasma renin activity was studied in rats 4 days after surgical lesions of the mediobasal hypothalamus, anterolateral deafferentation of the mediobasal hypothalamus, posterolateral deafferentation, or hypophysectomy. p-Chloroamphetamine 43-64 renin Rattus norvegicus 81-86 7043299-1 1982 The effect of the serotonin-releasing drug parachloroamphetamine (PCA) on plasma renin activity was studied in rats 4 days after surgical lesions of the mediobasal hypothalamus, anterolateral deafferentation of the mediobasal hypothalamus, posterolateral deafferentation, or hypophysectomy. p-Chloroamphetamine 66-69 renin Rattus norvegicus 81-86 7188049-0 1982 Renin-angiotensin-aldosterone system in hyper- and hypothyroid rats during sodium depletion. Sodium 75-81 renin Rattus norvegicus 0-5 15171019-0 1982 Effect of prostaglandins on renin release from rat renal cortical slices. Prostaglandins 10-24 renin Rattus norvegicus 28-33 6172661-2 1981 A significant increase (p less than 0.05) in renin granulation indices which was already apparent after 3 weeks of treatment with Teprotide was even more definitive after 10 weeks (p less than 0.01). Teprotide 130-139 renin Rattus norvegicus 45-50 7041211-1 1982 Circadian rhythms of plasma renin activity (PRA) is described in the ether anesthetized rat. Ether 69-74 renin Rattus norvegicus 28-33 7048468-6 1982 The stimulating effect of trilostane on plasma renin activity and the adrenal enlargement are not inhibited by propranolol or indomethacin. trilostane 26-36 renin Rattus norvegicus 47-52 7048468-8 1982 Increased renin and ACTH maintain normal basal steroid levels, and might impair the therapeutic effectiveness of trilostane. Steroids 47-54 renin Rattus norvegicus 10-15 7048468-8 1982 Increased renin and ACTH maintain normal basal steroid levels, and might impair the therapeutic effectiveness of trilostane. trilostane 113-123 renin Rattus norvegicus 10-15 6172661-4 1981 Findings pertaining to aldosterone production differed from those reported following acute administration of Teprotide wherein a decrease in the production of serum aldosterone and an increase in plasma renin activity was observed. Teprotide 109-118 renin Rattus norvegicus 203-208 7030085-9 1981 These results indicate that the hypotensive effect of water restriction in the two-kidney one-clip hypertensive rat model may be mediated, at least in part, through elevated circulating levels of vasopressin that subsequently inhibit renin release. Water 54-59 renin Rattus norvegicus 234-239 7028611-0 1981 Renin-like activity in the rat brain during the development of DOC-salt hypertension. Desoxycorticosterone 63-66 renin Rattus norvegicus 0-5 7028611-0 1981 Renin-like activity in the rat brain during the development of DOC-salt hypertension. Salts 67-71 renin Rattus norvegicus 0-5 7028620-5 1981 Beta-adrenergic stimulation with isoproterenol (ISO), 178 micron M, increased renin concentration threefold (11 +/- 2 ng AI). Isoproterenol 33-46 renin Rattus norvegicus 78-83 7028620-5 1981 Beta-adrenergic stimulation with isoproterenol (ISO), 178 micron M, increased renin concentration threefold (11 +/- 2 ng AI). Isoproterenol 48-51 renin Rattus norvegicus 78-83 7028611-5 1981 Concentration of the renin-like enzyme was significantly higher in the posterior hypophysis and in the brain stem of the experimental group; isorenin activity was higher in the hypothalamus, cerebral cortex, cerebellum, and brain stem of the DOC-salt-treated rats than in the control rats. Desoxycorticosterone 242-245 renin Rattus norvegicus 21-26 7028620-6 1981 The beta-blocker propranolol at 12 micron M halved ISO-stimulated renin, and at 120 micron M eliminated it. Propranolol 17-28 renin Rattus norvegicus 66-71 7028611-5 1981 Concentration of the renin-like enzyme was significantly higher in the posterior hypophysis and in the brain stem of the experimental group; isorenin activity was higher in the hypothalamus, cerebral cortex, cerebellum, and brain stem of the DOC-salt-treated rats than in the control rats. Salts 246-250 renin Rattus norvegicus 21-26 7028620-8 1981 Pretreating rast with DOCA and a high salt diet significantly reduced basal and abolished ISO-stimulated renin release. Desoxycorticosterone Acetate 22-26 renin Rattus norvegicus 105-110 7028620-8 1981 Pretreating rast with DOCA and a high salt diet significantly reduced basal and abolished ISO-stimulated renin release. Salts 38-42 renin Rattus norvegicus 105-110 7028620-9 1981 Increasing Krebs calcium (10 mM) did not affect basal but abolished ISO-stimulated renin release. krebs 11-16 renin Rattus norvegicus 83-88 7028620-9 1981 Increasing Krebs calcium (10 mM) did not affect basal but abolished ISO-stimulated renin release. Calcium 17-24 renin Rattus norvegicus 83-88 7028620-11 1981 Increasing Krebs potassium (50 mM) increased basal renin fourfold (14 ng AI) while the absolute increase from basal due to ISO remained the same (23 ng AI). krebs 11-16 renin Rattus norvegicus 51-56 7032812-9 1981 Plasma renin activity and plasma aldosterone concentration were decreased by intraventricular injection of dopamine, and increased by that of metoclopramide. Dopamine 107-115 renin Rattus norvegicus 7-12 7032812-9 1981 Plasma renin activity and plasma aldosterone concentration were decreased by intraventricular injection of dopamine, and increased by that of metoclopramide. Metoclopramide 142-156 renin Rattus norvegicus 7-12 7028620-11 1981 Increasing Krebs potassium (50 mM) increased basal renin fourfold (14 ng AI) while the absolute increase from basal due to ISO remained the same (23 ng AI). Potassium 17-26 renin Rattus norvegicus 51-56 7028612-0 1981 Role of the anteroventral third ventricle region and the renin angiotensin system in methylprednisolone hypertension. Methylprednisolone 85-103 renin Rattus norvegicus 57-62 7034664-0 1981 Dissociation of antipolyuric action and increase in plasma renin activity caused by chlorothiazide in Brattleboro rats. Chlorothiazide 84-98 renin Rattus norvegicus 59-64 7299493-5 1981 Juxtaglomerular granulation in the kidneys indicated that renin secretion was adequate in thiamin-deficient rats. Thiamine 90-97 renin Rattus norvegicus 58-63 6457138-0 1981 Pharmacological evidence for a role of brain serotonin in the maintenance of plasma renin activity in unanesthetized rats. Serotonin 45-54 renin Rattus norvegicus 84-89 6457138-1 1981 To determine whether serotonin is involved in the regulation of renin secretion in unanesthetized rats, plasma renin activity was measured in animals treated with the serotonin-depleting drugs p-chlorophenylalanine and 5,7-dihydroxytryptamine, with the serotonin releasing drug p-chloroamphetamine and with the serotonin agonist quipazine. Serotonin 21-30 renin Rattus norvegicus 64-69 6457138-3 1981 p-Chlorophenylalanine decreased plasma renin activity and p-chlorophenylalanine plus 5-hydroxytryptophan increased plasma renin activity. Fenclonine 0-21 renin Rattus norvegicus 39-44 6457138-3 1981 p-Chlorophenylalanine decreased plasma renin activity and p-chlorophenylalanine plus 5-hydroxytryptophan increased plasma renin activity. 5-Hydroxytryptophan 85-104 renin Rattus norvegicus 122-127 6457138-4 1981 Plasma renin activity was also reduced in rats that had received intraventricular 5,7-dihydroxytryptamine after pretreatment with desmethylimipramine. 5,7-Dihydroxytryptamine 82-105 renin Rattus norvegicus 7-12 6457138-4 1981 Plasma renin activity was also reduced in rats that had received intraventricular 5,7-dihydroxytryptamine after pretreatment with desmethylimipramine. Desipramine 130-149 renin Rattus norvegicus 7-12 6457138-6 1981 p-Chloroamphetamine and quipazine produced dose-dependent increases in plasma renin activity and plasma corticosterone. p-Chloroamphetamine 0-19 renin Rattus norvegicus 78-83 6457138-6 1981 p-Chloroamphetamine and quipazine produced dose-dependent increases in plasma renin activity and plasma corticosterone. Quipazine 24-33 renin Rattus norvegicus 78-83 6457138-7 1981 The increase in plasma renin activity produce by quipazine was more rapid than that produced by p-chloroamphetamine. Quipazine 49-58 renin Rattus norvegicus 23-28 6275810-0 1981 Converting enzyme inhibition and modulation of plasma renin activity with captopril in anesthetized rats. Captopril 74-83 renin Rattus norvegicus 54-59 6275810-5 1981 Captopril effected a marked elevation of plasma renin activity by its blocking action on the angiotensin II-mediated negative feedback of renin release without markedly altering systemic blood pressure and heart rate. Captopril 0-9 renin Rattus norvegicus 48-53 6275810-5 1981 Captopril effected a marked elevation of plasma renin activity by its blocking action on the angiotensin II-mediated negative feedback of renin release without markedly altering systemic blood pressure and heart rate. Captopril 0-9 renin Rattus norvegicus 138-143 6275810-8 1981 )-induced renin release, tended to suppress the captopril-induced renin release. Captopril 48-57 renin Rattus norvegicus 10-15 7033921-4 1981 Such renin depleted rats were incapable of releasing renin (as judged by increase in plasma renin level) in response to severely hypotensive haemorrhage and had very blunted renin release responses to pentobarbital and urethane anesthesia (59 and 17% of normal respectively). Pentobarbital 201-214 renin Rattus norvegicus 5-10 7033921-4 1981 Such renin depleted rats were incapable of releasing renin (as judged by increase in plasma renin level) in response to severely hypotensive haemorrhage and had very blunted renin release responses to pentobarbital and urethane anesthesia (59 and 17% of normal respectively). Urethane 219-227 renin Rattus norvegicus 5-10 6457138-8 1981 The effects of p-chloroamphetamine on plasma renin activity and plasma corticosterone were prevented by prior administration of p-chlorophenylalanine. p-Chloroamphetamine 15-34 renin Rattus norvegicus 45-50 6457138-8 1981 The effects of p-chloroamphetamine on plasma renin activity and plasma corticosterone were prevented by prior administration of p-chlorophenylalanine. Fenclonine 128-149 renin Rattus norvegicus 45-50 6457138-9 1981 The renin stimulating effect of p-chloroamphetamine was unaffected by adrenalectomy. p-Chloroamphetamine 32-51 renin Rattus norvegicus 4-9 6457138-11 1981 The data support the hypothesis that in rats release of serotonin within the central nervous system increases renin secretion and corticosterone secretion and that the increase in renin is independent of the increase in corticosterone. Serotonin 56-65 renin Rattus norvegicus 110-115 6797255-6 1981 Increased endogenous PG-levels were associated with only a modest (insignificant) increase in renin release under the present conditions. Prostaglandins 21-23 renin Rattus norvegicus 94-99 6797255-7 1981 Saline loading acutely depressed PGE2 and PGF2 alpha urinary excretion rates and plasma renin concentration (PRC). Sodium Chloride 0-6 renin Rattus norvegicus 88-93 6275810-8 1981 )-induced renin release, tended to suppress the captopril-induced renin release. Captopril 48-57 renin Rattus norvegicus 66-71 6275810-11 1981 These findings suggest that captopril specifically inhibits converting enzyme and kininase II, and that captopril-induced renin release is partially associated with the beta-adrenergic system without dedication by prostaglandins. Captopril 104-113 renin Rattus norvegicus 122-127 7034664-1 1981 The previous finding that chlorothiazide (about 250 mg/day) induces a sustained reduction in the polyuria of homozygous Brattleboro (BB) female rats, as well as an increase to about 250% of plasma renin activity was confirmed. Chlorothiazide 26-40 renin Rattus norvegicus 197-202 7028226-1 1981 Dose-response relationships of furosemide to its diuretic and cardiovascular actions and its effects on plasma renin activity (PRA) were evaluated in unanesthetized rats. Furosemide 31-41 renin Rattus norvegicus 111-116 7028226-7 1981 Furosemide did not induce significant changes in blood pressure and heart rate, but it did alter the renin dependency of the blood pressure as assessed by Saralasin. Furosemide 0-10 renin Rattus norvegicus 101-106 7034664-2 1981 Disruption of the renin-angiotensin system by either the angiotensin antagonist saralasin or the beta-blocking agent propranolol does not interfere with chlorothiazide antidiuresis. Propranolol 117-128 renin Rattus norvegicus 18-23 7029031-0 1981 Central and peripheral effects of dopamine on the renin-angiotensin-aldosterone system in conscious rats. Dopamine 34-42 renin Rattus norvegicus 50-55 7298111-5 1981 In spite of the massive diuretic effect, potassium loading significantly attenuated the increased plasma renin activity (PRA) induced by renal artery constriction, while it further enhanced the increased plasma aldosterone concentration (PAC) in two-kidney, one clip Goldblatt hypertensive rats. Potassium 41-50 renin Rattus norvegicus 105-110 7029031-3 1981 Dopamine (100 micrograms/kg), when injected i.c.v., decreased plasma renin activity (PRA) and plasma aldosterone concentration (PA), while metoclopramide (50 micrograms/kg, i.c.v.) Dopamine 0-8 renin Rattus norvegicus 69-74 7300020-3 1981 After treatment with thyroxine (2.5 mg/kg/day), plasma renin substrate concentration, plasma renin activity, plasma aldosterone concentration and the rate of renin substrate synthesis were all significantly increased. Thyroxine 21-30 renin Rattus norvegicus 55-60 7029031-13 1981 These results suggest that the dopaminergic system in the brain regulates renin secretion, thereby changing PA. Protactinium 108-110 renin Rattus norvegicus 74-79 7300020-3 1981 After treatment with thyroxine (2.5 mg/kg/day), plasma renin substrate concentration, plasma renin activity, plasma aldosterone concentration and the rate of renin substrate synthesis were all significantly increased. Thyroxine 21-30 renin Rattus norvegicus 93-98 7300020-3 1981 After treatment with thyroxine (2.5 mg/kg/day), plasma renin substrate concentration, plasma renin activity, plasma aldosterone concentration and the rate of renin substrate synthesis were all significantly increased. Thyroxine 21-30 renin Rattus norvegicus 93-98 7300020-0 1981 Effects of angiotension II, thyroxine and estrogen on plasma renin substrate concentration and renin substrate production by the liver. Thyroxine 28-37 renin Rattus norvegicus 61-66 7300020-4 1981 17 beta estradiol (2 mg) raised both plasma renin substrate concentration and the amount of renin substrate production by the liver. Estradiol 0-17 renin Rattus norvegicus 44-49 7300020-4 1981 17 beta estradiol (2 mg) raised both plasma renin substrate concentration and the amount of renin substrate production by the liver. Estradiol 0-17 renin Rattus norvegicus 92-97 7021590-1 1981 Although dietary potassium deficiency (KD) results in an increase in plasma renin activity (PRA), the mechanism of this effect has not been elucidated. Potassium 17-26 renin Rattus norvegicus 76-81 7032214-5 1981 Mg-ATP (0.5 and 5 mM) as well as Mg-GTP (5 mM) stabilized renin granules at +37 degrees C, pH 6.5, but the corresponding nitrogen analogues Mg-AMP-PNP and Mg-GMP-PNP (0.5 and 5 mM) were not effective. Adenosine Triphosphate 0-6 renin Rattus norvegicus 58-63 7032214-5 1981 Mg-ATP (0.5 and 5 mM) as well as Mg-GTP (5 mM) stabilized renin granules at +37 degrees C, pH 6.5, but the corresponding nitrogen analogues Mg-AMP-PNP and Mg-GMP-PNP (0.5 and 5 mM) were not effective. magnesium GTP 33-39 renin Rattus norvegicus 58-63 7021040-6 1981 The plasma renin activity was markedly decreased after injection of saralasin and captopril into the cerebral ventricles of two-kidney, one-clip Goldblatt hypertensive rats. Captopril 82-91 renin Rattus norvegicus 11-16 7021040-7 1981 Conversely, in DOC-salt hypertensive rats, the plasma renin activity was markedly increased after injection of these two agents. Salts 19-23 renin Rattus norvegicus 54-59 6268171-1 1981 Tonin is an enzyme found in the rat submaxillary glands which liberates angiotensin II from angiotensinogen, the Skeggs tetradecapeptide renin substrate, and angiotensin I. skeggs 113-119 renin Rattus norvegicus 137-142 6268911-0 1981 Effect of diltiazem, a calcium antagonist, on renin secretion from rat kidney slices. Diltiazem 10-19 renin Rattus norvegicus 46-51 6268171-1 1981 Tonin is an enzyme found in the rat submaxillary glands which liberates angiotensin II from angiotensinogen, the Skeggs tetradecapeptide renin substrate, and angiotensin I. tetradecapeptide 120-136 renin Rattus norvegicus 137-142 7023920-0 1981 Inhibition of the isoprenaline-induced renin release by bilateral vagotomy is mediated by vasopressin. Isoproterenol 18-30 renin Rattus norvegicus 39-44 7016365-0 1981 Indomethacin decreases arterial blood pressure and plasma renin activity in rats with aortic ligation. Indomethacin 0-12 renin Rattus norvegicus 58-63 7016365-9 1981 These data provide evidence that the prostaglandin system is involved in the release of renin and in the pathogenesis of elevated blood pressure in this model of renin-dependent hypertension. Prostaglandins 37-50 renin Rattus norvegicus 88-93 7016365-9 1981 These data provide evidence that the prostaglandin system is involved in the release of renin and in the pathogenesis of elevated blood pressure in this model of renin-dependent hypertension. Prostaglandins 37-50 renin Rattus norvegicus 162-167 7023920-1 1981 The influence of cervical vagotomy on the isoprenaline-induced renin and vasopressin release was investigated in rats. Isoproterenol 42-54 renin Rattus norvegicus 63-68 7023920-7 1981 We conclude that, after bilateral vagotomy, isoprenaline elevated plasma vasopressin levels, which then attenuated the concurrent renin release, substantiating that endogenous vasopressin might participate in the control of renin release. Isoproterenol 44-56 renin Rattus norvegicus 130-135 7023920-7 1981 We conclude that, after bilateral vagotomy, isoprenaline elevated plasma vasopressin levels, which then attenuated the concurrent renin release, substantiating that endogenous vasopressin might participate in the control of renin release. Isoproterenol 44-56 renin Rattus norvegicus 224-229 7018257-0 1981 Effects of sodium intake and Goldblatt hypertension on renin release in rat kidney slices. Sodium 11-17 renin Rattus norvegicus 55-60 6788803-3 1981 We have tested the hypothesis that the vasodilatory effect of mannitol in the ischemic rat kidney is mediated by one of the vasoactive renal hormone systems: renin-angiotension, kallikrein-kinin, or prostaglandins. Mannitol 62-70 renin Rattus norvegicus 158-163 6117610-3 1981 Bucumolol lowered blood pressure and decreased plasma renin concentration (PRC) in both acute and long-term experiments. bucumolol 0-9 renin Rattus norvegicus 54-59 6117610-6 1981 On the other hand, propranolol did not lower blood pressure in acute experiment while it decreased renin release. Propranolol 19-30 renin Rattus norvegicus 99-104 6117610-7 1981 These results suggest that inhibition of renin release is involved in the antihypertensive action of bucumolol. bucumolol 101-110 renin Rattus norvegicus 41-46 6117612-8 1981 Bometolol treatment at the above doses decreased plasma renin activity, heart and kidney weights, and incidence of vascular lesion in either hypertensive rat. bometolol 0-9 renin Rattus norvegicus 56-61 7033500-0 1981 The renin-angiotensin system in drinking and cardiovascular responses to isoprenaline in the rat. Isoproterenol 73-85 renin Rattus norvegicus 4-9 7033500-2 1981 We investigated the role of the renin-angiotensin system in isoprenaline-induced drinking in the rat. Isoproterenol 60-72 renin Rattus norvegicus 32-37 7033500-14 1981 We conclude that the renin-angiotensin system has a direct and essential role in the drinking response to isoprenaline. Isoproterenol 106-118 renin Rattus norvegicus 21-26 6117262-4 1981 Atenolol and propranolol prevent genetic hypertension by I) reducing cardiac output, a reduction which is not neutralised by the simultaneous change in peripheral resistance, 2) decreasing plasma renin concentrations, and 3) limiting the development of myocardial hypertrophy. Atenolol 0-8 renin Rattus norvegicus 196-201 6117262-4 1981 Atenolol and propranolol prevent genetic hypertension by I) reducing cardiac output, a reduction which is not neutralised by the simultaneous change in peripheral resistance, 2) decreasing plasma renin concentrations, and 3) limiting the development of myocardial hypertrophy. Propranolol 13-24 renin Rattus norvegicus 196-201 7018257-2 1981 The low sodium diet significantly elevated plasma and kidney renin activity (KRA) and base-line renin release (BRR). Sodium 8-14 renin Rattus norvegicus 61-66 7018257-2 1981 The low sodium diet significantly elevated plasma and kidney renin activity (KRA) and base-line renin release (BRR). Sodium 8-14 renin Rattus norvegicus 96-101 7018258-2 1981 Isoproterenol (1 microgram.kg-1.min-1) infusion into intact rats increased plasma renin activity (PRA) eightfold. Isoproterenol 0-13 renin Rattus norvegicus 82-87 6973156-3 1981 l-5-Hydroxytryptophan (5-HTP), the precursor of serotonin, is also a potent dipsogen which induces drinking by way of the renin-angiotensin system. 5-Hydroxytryptophan 0-21 renin Rattus norvegicus 122-127 6973156-3 1981 l-5-Hydroxytryptophan (5-HTP), the precursor of serotonin, is also a potent dipsogen which induces drinking by way of the renin-angiotensin system. 5-Hydroxytryptophan 23-28 renin Rattus norvegicus 122-127 6973156-3 1981 l-5-Hydroxytryptophan (5-HTP), the precursor of serotonin, is also a potent dipsogen which induces drinking by way of the renin-angiotensin system. Serotonin 48-57 renin Rattus norvegicus 122-127 6273629-7 1981 The hypotensive effect of YS-980 is attributed mainly to suppression of the renin angiotensin system. (4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid 26-32 renin Rattus norvegicus 76-81 6973156-3 1981 l-5-Hydroxytryptophan (5-HTP), the precursor of serotonin, is also a potent dipsogen which induces drinking by way of the renin-angiotensin system. dipsogen 76-84 renin Rattus norvegicus 122-127 7031229-0 1981 Calcium dependency of the inhibitory effect of antidiuretic hormone on in vitro renin secretion in rats. Calcium 0-7 renin Rattus norvegicus 80-85 7019933-0 1981 Effects of serotonin and L-5-hydroxytryptophan on plasma renin activity in rats. Serotonin 11-20 renin Rattus norvegicus 57-62 7031229-6 1981 Ca depletion (incubation of slices in medium containing Na2EGTA and no added CaCl2) stimulated renin secretion and eventually abolished the inhibitory effect of ADH. na2egta 56-63 renin Rattus norvegicus 95-100 7019933-0 1981 Effects of serotonin and L-5-hydroxytryptophan on plasma renin activity in rats. 5-Hydroxytryptophan 25-46 renin Rattus norvegicus 57-62 7019933-8 1981 The mechanism by which activation of the renin-angiotensin system occurs following peripheral administration of either 5-HTP or serotonin remains for further study. 5-Hydroxytryptophan 119-124 renin Rattus norvegicus 41-46 7019933-8 1981 The mechanism by which activation of the renin-angiotensin system occurs following peripheral administration of either 5-HTP or serotonin remains for further study. Serotonin 128-137 renin Rattus norvegicus 41-46 6260459-6 1981 Isoproterenol (8 x 10(-7) M) increased renin and PGE2 release which was blocked by indomethacin (10(-4) M) and meclofenamate (10(-4) M). Indomethacin 83-95 renin Rattus norvegicus 39-44 7018800-0 1981 Renin response to volume contraction and indomethacin in spontaneously hypertensive rats. Indomethacin 41-53 renin Rattus norvegicus 0-5 7018800-2 1981 The effects of volume contraction and indomethacin on renin response were examined in spontaneously hypertensive rats and Wistar-Kyoto normotensive rats. Indomethacin 38-50 renin Rattus norvegicus 54-59 7018800-9 1981 In contrast, indomethacin pretreatment caused renin to rise in response to frusemide in spontaneously hypertensive rats (4.7 +/- 0.8 to 27.1 +/- 1.8 ng h-1 ml-1). Indomethacin 13-25 renin Rattus norvegicus 46-51 7018800-9 1981 In contrast, indomethacin pretreatment caused renin to rise in response to frusemide in spontaneously hypertensive rats (4.7 +/- 0.8 to 27.1 +/- 1.8 ng h-1 ml-1). Furosemide 75-84 renin Rattus norvegicus 46-51 7018800-11 1981 These findings suggest that a prostaglandin normally inhibits the renin response of spontaneously hypertensive rats to frusemide-induced volume contraction. Prostaglandins 30-43 renin Rattus norvegicus 66-71 6260459-0 1981 The role of renal prostaglandins in the renin response to isoproterenol in the rat in vitro. Prostaglandins 18-32 renin Rattus norvegicus 40-45 6260459-0 1981 The role of renal prostaglandins in the renin response to isoproterenol in the rat in vitro. Isoproterenol 58-71 renin Rattus norvegicus 40-45 6260459-6 1981 Isoproterenol (8 x 10(-7) M) increased renin and PGE2 release which was blocked by indomethacin (10(-4) M) and meclofenamate (10(-4) M). Meclofenamic Acid 111-124 renin Rattus norvegicus 39-44 6260459-1 1981 Renal prostaglandins (PGs) have been considered to be important mediators of renin release. Prostaglandins 6-20 renin Rattus norvegicus 77-82 7018800-11 1981 These findings suggest that a prostaglandin normally inhibits the renin response of spontaneously hypertensive rats to frusemide-induced volume contraction. Furosemide 119-128 renin Rattus norvegicus 66-71 7018800-12 1981 Inhibition of prostaglandin synthesis allows volume contraction to stimulate renin release. Prostaglandins 14-27 renin Rattus norvegicus 77-82 6260459-7 1981 Dibutyryl cAMP stimulated renin release significantly, and this effect was not blocked by indomethacin (10(-4) M). dibutyryl 0-9 renin Rattus norvegicus 26-31 6260459-1 1981 Renal prostaglandins (PGs) have been considered to be important mediators of renin release. Prostaglandins 22-25 renin Rattus norvegicus 77-82 6260459-3 1981 To investigate the role of PGs in the control of isoproterenol-induced renin release, we studied the effect of two inhibitors of PG synthesis, indomethacin and meclofenamate, on the renin release stimulated by isoproterenol and dibutyryl cAMP. Isoproterenol 49-62 renin Rattus norvegicus 71-76 6260459-7 1981 Dibutyryl cAMP stimulated renin release significantly, and this effect was not blocked by indomethacin (10(-4) M). Cyclic AMP 10-14 renin Rattus norvegicus 26-31 6260459-3 1981 To investigate the role of PGs in the control of isoproterenol-induced renin release, we studied the effect of two inhibitors of PG synthesis, indomethacin and meclofenamate, on the renin release stimulated by isoproterenol and dibutyryl cAMP. Indomethacin 143-155 renin Rattus norvegicus 182-187 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Prostaglandins 55-57 renin Rattus norvegicus 69-74 6260459-3 1981 To investigate the role of PGs in the control of isoproterenol-induced renin release, we studied the effect of two inhibitors of PG synthesis, indomethacin and meclofenamate, on the renin release stimulated by isoproterenol and dibutyryl cAMP. Meclofenamic Acid 160-173 renin Rattus norvegicus 182-187 6260459-3 1981 To investigate the role of PGs in the control of isoproterenol-induced renin release, we studied the effect of two inhibitors of PG synthesis, indomethacin and meclofenamate, on the renin release stimulated by isoproterenol and dibutyryl cAMP. Isoproterenol 210-223 renin Rattus norvegicus 182-187 6260459-6 1981 Isoproterenol (8 x 10(-7) M) increased renin and PGE2 release which was blocked by indomethacin (10(-4) M) and meclofenamate (10(-4) M). Isoproterenol 0-13 renin Rattus norvegicus 39-44 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Prostaglandins 55-57 renin Rattus norvegicus 228-233 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Prostaglandins 221-224 renin Rattus norvegicus 69-74 7021411-4 1981 Kallikrein-stimulated renin release was completely abolished by trasylol and by amiloride, but was not affected by soybean trypsin inhibitor. Amiloride 80-89 renin Rattus norvegicus 22-27 7021411-6 1981 Kallikrein-stimulated renin release was not blocked by propranolol, trasylol did not block isoproterenol, and dibutyryl cyclic AMP stimulated renin release, indicating that kallikrein may not play a role in the beta-adrenergic mechanism of renin release. Bucladesine 110-130 renin Rattus norvegicus 142-147 7021411-6 1981 Kallikrein-stimulated renin release was not blocked by propranolol, trasylol did not block isoproterenol, and dibutyryl cyclic AMP stimulated renin release, indicating that kallikrein may not play a role in the beta-adrenergic mechanism of renin release. Bucladesine 110-130 renin Rattus norvegicus 142-147 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Prostaglandins 221-224 renin Rattus norvegicus 228-233 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Cyclic AMP 312-316 renin Rattus norvegicus 69-74 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Cyclic AMP 312-316 renin Rattus norvegicus 228-233 6114728-0 1981 Vascular responses to REN-293 (2-amino-3[3, 5-dihydroxyphenyl]-1-propanol hydrochloride)--a new sympathomimetic agent. 2-amino-3[3, 5-dihydroxyphenyl]-1-propanol hydrochloride 31-87 renin Rattus norvegicus 22-25 7018794-12 1981 This study has also confirmed a hypotensive action of captopril in anephric rats when plasma renin activity is undetectable. Captopril 54-63 renin Rattus norvegicus 93-98 6269812-1 1981 Observations with both captopril and teprotide suggest interplay of the renin angiotensin and sympathetic nervous systems during sodium depletion. Captopril 23-32 renin Rattus norvegicus 72-77 7012436-0 1981 Effect of indomethacin on blood pressure in rats with renovascular hypertension: dependence on plasma renin activity. Indomethacin 10-22 renin Rattus norvegicus 102-107 7006412-6 1981 According to these observations, experimental edema stimulates late steps of aldosterone biosynthesis in potassium-depleted rats by mediation of the kidneys, most likely through the renin-angiotensin system. Aldosterone 77-88 renin Rattus norvegicus 182-187 7006412-6 1981 According to these observations, experimental edema stimulates late steps of aldosterone biosynthesis in potassium-depleted rats by mediation of the kidneys, most likely through the renin-angiotensin system. Potassium 105-114 renin Rattus norvegicus 182-187 7023495-4 1981 After single oral administration, budralazine was about 8 times less potent than hydralazine in increasing plasma renin activity in normotensive rats. budralazine 34-45 renin Rattus norvegicus 114-119 7023495-4 1981 After single oral administration, budralazine was about 8 times less potent than hydralazine in increasing plasma renin activity in normotensive rats. Hydralazine 81-92 renin Rattus norvegicus 114-119 7019205-2 1981 The renin obtained by the one-step purification was electrophoretically homogenous on SDS-polyacrylamide gel and was as active as an absolutely pure renin. Sodium Dodecyl Sulfate 86-89 renin Rattus norvegicus 4-9 7019205-2 1981 The renin obtained by the one-step purification was electrophoretically homogenous on SDS-polyacrylamide gel and was as active as an absolutely pure renin. polyacrylamide 90-104 renin Rattus norvegicus 4-9 7019205-3 1981 The renin purified by the affinity column could be separated into five active components by chromatography on CM-cellulose. 7,8-diacetoxy-3-(4-nitrophenyl)coumarin 111-123 renin Rattus norvegicus 4-9 7012843-0 1981 Direct action of prostaglandins on renin release from rat renal cortical slices. Prostaglandins 17-31 renin Rattus norvegicus 35-40 7011052-0 1981 Effects of indomethacin on plasma renin activity in the conscious rat. Indomethacin 11-23 renin Rattus norvegicus 34-39 7011052-1 1981 The role of prostaglandins in the control of renin release in vivo was evaluated in the conscious rat. Prostaglandins 12-26 renin Rattus norvegicus 45-50 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Prostaglandins 42-55 renin Rattus norvegicus 103-108 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Prostaglandins 42-55 renin Rattus norvegicus 228-233 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Indomethacin 69-81 renin Rattus norvegicus 103-108 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Indomethacin 69-81 renin Rattus norvegicus 228-233 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Prostaglandins 171-185 renin Rattus norvegicus 103-108 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Prostaglandins 171-185 renin Rattus norvegicus 228-233 6260644-4 1981 These cells responded to epinephrine and norepinephrine by increasing both synthesis and release of renin. Epinephrine 25-36 renin Rattus norvegicus 100-105 6260644-4 1981 These cells responded to epinephrine and norepinephrine by increasing both synthesis and release of renin. Norepinephrine 41-55 renin Rattus norvegicus 100-105 6260644-9 1981 Angiotensin II inhibited release, while saline extracts of clipped kidney from renal hypertensive rats stimulated renin release by these cells. Sodium Chloride 40-46 renin Rattus norvegicus 114-119 7009830-0 1981 Influence of dietary sodium on renin angiotensin system involvement in sodium nitroprusside hypotension in conscious rats. Sodium 21-27 renin Rattus norvegicus 31-36 7009830-0 1981 Influence of dietary sodium on renin angiotensin system involvement in sodium nitroprusside hypotension in conscious rats. Nitroprusside 71-91 renin Rattus norvegicus 31-36 7004861-3 1981 T3 injection corrected the changes in the plasma renin-angiotensin system of thyroidectomized rats within 20-40 h. After ethinylestradiol treatment, the PRS in thyroidectomized rats rose in the same proportion as that in normal rats, but remained below the normal level. Ethinyl Estradiol 121-137 renin Rattus norvegicus 49-54 7004861-5 1981 Isoproterenol increased PRA and plasma renin concentration in control animals but had no effect on thyroidectomized rats. Isoproterenol 0-13 renin Rattus norvegicus 39-44 7004861-6 1981 From the above results it may be concluded that angiotensinogen production is dependent on thyroid hormones and that renin release depends on beta-adrenergic receptor sensitivity to catecholamines, which is reduced by thyroidectomy. Catecholamines 182-196 renin Rattus norvegicus 117-122 7026195-4 1981 On the 8th day of DEX administration, plasma renin substrate (PRS) was significantly elevated compared to control rats, whereas plasma aldosterone concentration (PAC) was not significantly different from that of control rats. Dexamethasone 18-21 renin Rattus norvegicus 45-50 7472089-0 1981 Role of prolactin and the renin-angiotensin system in mediating dopaminergic control of aldosterone secretion in the rat. Aldosterone 88-99 renin Rattus norvegicus 26-31 6269812-1 1981 Observations with both captopril and teprotide suggest interplay of the renin angiotensin and sympathetic nervous systems during sodium depletion. Teprotide 37-46 renin Rattus norvegicus 72-77 6269812-1 1981 Observations with both captopril and teprotide suggest interplay of the renin angiotensin and sympathetic nervous systems during sodium depletion. Sodium 129-135 renin Rattus norvegicus 72-77 7009102-1 1981 The effect of metoclopramide, a procainamide derivative with dopamine antagonistic properties, and L-dopa on plasma renin activity (PRA) was studied in adult rats. Levodopa 99-105 renin Rattus norvegicus 116-121 7014835-0 1981 Renin release from isolated rat glomeruli: seasonal variations and effects of D600 on the response to calcium deprivation. Calcium 102-109 renin Rattus norvegicus 0-5 7014835-4 1981 Reduction of superfusate calcium concentration caused an increase in renin release, which was significantly higher during the summer (May-August) than during the rest of the year. Calcium 25-32 renin Rattus norvegicus 69-74 7014835-6 1981 Addition of D600 (2 X 10(-4) M) to a calcium-free medium in the low responsive period caused a markedly increased renin release. Gallopamil 12-16 renin Rattus norvegicus 114-119 7014835-6 1981 Addition of D600 (2 X 10(-4) M) to a calcium-free medium in the low responsive period caused a markedly increased renin release. Calcium 37-44 renin Rattus norvegicus 114-119 7014835-9 1981 It is suggested that the effect of calcium on renin release predominantly is mediated by changes in calcium bound to the plasma membrane of the juxtaglomerular cell. Calcium 35-42 renin Rattus norvegicus 46-51 7014835-9 1981 It is suggested that the effect of calcium on renin release predominantly is mediated by changes in calcium bound to the plasma membrane of the juxtaglomerular cell. Calcium 100-107 renin Rattus norvegicus 46-51 7048119-0 1981 [Effect of indomethacin on renin secretion in isolated perfused rat kidney (author"s transl)]. Indomethacin 11-23 renin Rattus norvegicus 27-32 7033809-3 1981 The plasma renin activity was elevated initially probably due to the ether anaesthesia. Ether 69-74 renin Rattus norvegicus 11-16 6172718-0 1981 Effect of angiotensin I converting enzyme inhibitor, SQ 14225, on renin production and release. Captopril 53-61 renin Rattus norvegicus 66-71 7004211-5 1980 Isoproterenol at 1.78 or 8.1 X 10(-4) M produced a significant release of renin, but the concentration of PGE2 was unaffected. Isoproterenol 0-13 renin Rattus norvegicus 74-79 6172718-9 1981 Our findings suggest that CEI administration may initially effect stimulation of renin release from the juxtaglomerular apparatus and that prolonged CEI administration results in a gradual stimulation of renin production. coelenteramide 26-29 renin Rattus norvegicus 81-86 7008812-3 1980 Carbamylcholine has been injected together with captopril, an inhibitor of the enzyme converting angiotensin I into angiotensin II, and with propranolol, which blocks the renin beta-receptors respectively. Carbachol 0-15 renin Rattus norvegicus 171-176 7008812-3 1980 Carbamylcholine has been injected together with captopril, an inhibitor of the enzyme converting angiotensin I into angiotensin II, and with propranolol, which blocks the renin beta-receptors respectively. Propranolol 141-152 renin Rattus norvegicus 171-176 7004211-6 1980 Isoproterenol-stimulated renin release was blocked by 1.2 X 10(-4) M propranolol but was unaffected by 6.3 X 10(-6) M meclofenamate. Isoproterenol 0-13 renin Rattus norvegicus 25-30 7002102-1 1980 Captopril (SQ 14225), a converting enzyme inhibitor, significantly lowered the arterial pressure (AP) of rats with angiotensin-salt hypertension, a hypertensive state associated with sodium retention, volume expansion, and suppression of both renin and aldosterone secretion. Captopril 0-9 renin Rattus norvegicus 243-248 7004211-6 1980 Isoproterenol-stimulated renin release was blocked by 1.2 X 10(-4) M propranolol but was unaffected by 6.3 X 10(-6) M meclofenamate. Propranolol 69-80 renin Rattus norvegicus 25-30 7002102-5 1980 The mechanism of action of captopril in a sodium-volume-expanded, renin-aldosterone-suppressed state is unknown. Captopril 27-36 renin Rattus norvegicus 66-71 7004211-8 1980 Arachidonic acid administered at 1.6 or 16.0 X 10(-5) M produced a marked increase in PG synthesis and stimulated a significant release of renin. Arachidonic Acid 0-16 renin Rattus norvegicus 139-144 7004211-9 1980 Treatment of glomeruli with 6.3 X 10(-6) M meclofenamate attenuated PGE2 synthesis and abolished renin release, but 1.2 X 10(-4) M propranolol had no effect on PG synthesis or the coincident release of renin. Meclofenamic Acid 43-56 renin Rattus norvegicus 97-102 7018493-0 1980 A qualitative difference in plasma renin activity in Dahl rats susceptible or resistant to salt-induced hypertension. Salts 91-95 renin Rattus norvegicus 35-40 7004728-4 1980 Active renin increased with delivery of extra sodium by microperfusion to the macula densa and this increase was similar to that achieved with acidification. Sodium 46-52 renin Rattus norvegicus 7-12 7004716-2 1980 In rats, intra-arterial metoclopramide, a dopamine antagonist, resulted in an elevation of plasma aldosterone at 5 min and plasma renin activity at 10 min and peak aldosterone and renin responses at 10 and 30 min respectively. Metoclopramide 24-38 renin Rattus norvegicus 130-135 7004716-2 1980 In rats, intra-arterial metoclopramide, a dopamine antagonist, resulted in an elevation of plasma aldosterone at 5 min and plasma renin activity at 10 min and peak aldosterone and renin responses at 10 and 30 min respectively. Metoclopramide 24-38 renin Rattus norvegicus 180-185 7004716-4 1980 Pre-administration of L-dopa blunted and delayed aldosterone and renin responses to metoclopramide, indicating that metoclopramide-induced plasma aldosterone and plasma renin activity increments are mediated by a direct effect of blockade of dopamine receptors rather than other effects of this drug. Levodopa 22-28 renin Rattus norvegicus 65-70 7004728-6 1980 In rats pretreated with an inhibitor of protein synthesis active renin increased when extra sodium was delivered to the macula densa. Sodium 92-98 renin Rattus norvegicus 65-70 7004716-4 1980 Pre-administration of L-dopa blunted and delayed aldosterone and renin responses to metoclopramide, indicating that metoclopramide-induced plasma aldosterone and plasma renin activity increments are mediated by a direct effect of blockade of dopamine receptors rather than other effects of this drug. Levodopa 22-28 renin Rattus norvegicus 169-174 7004728-8 1980 Salt intake changed the amount of renin present in the juxtaglomerular apparatus. Salts 0-4 renin Rattus norvegicus 34-39 7004716-4 1980 Pre-administration of L-dopa blunted and delayed aldosterone and renin responses to metoclopramide, indicating that metoclopramide-induced plasma aldosterone and plasma renin activity increments are mediated by a direct effect of blockade of dopamine receptors rather than other effects of this drug. Metoclopramide 84-98 renin Rattus norvegicus 65-70 7004716-4 1980 Pre-administration of L-dopa blunted and delayed aldosterone and renin responses to metoclopramide, indicating that metoclopramide-induced plasma aldosterone and plasma renin activity increments are mediated by a direct effect of blockade of dopamine receptors rather than other effects of this drug. Metoclopramide 84-98 renin Rattus norvegicus 169-174 7004716-4 1980 Pre-administration of L-dopa blunted and delayed aldosterone and renin responses to metoclopramide, indicating that metoclopramide-induced plasma aldosterone and plasma renin activity increments are mediated by a direct effect of blockade of dopamine receptors rather than other effects of this drug. Metoclopramide 116-130 renin Rattus norvegicus 65-70 7004716-4 1980 Pre-administration of L-dopa blunted and delayed aldosterone and renin responses to metoclopramide, indicating that metoclopramide-induced plasma aldosterone and plasma renin activity increments are mediated by a direct effect of blockade of dopamine receptors rather than other effects of this drug. Metoclopramide 116-130 renin Rattus norvegicus 169-174 7449251-0 1980 Effects of prostaglandins on renin substrate production by the liver. Prostaglandins 11-25 renin Rattus norvegicus 29-34 7449251-6 1980 The increase in plasma renin substrate level and production of renin substrate by the liver after nephrectomy was markedly suppressed by the treatment with PGE1 or PGE2. Alprostadil 156-160 renin Rattus norvegicus 23-28 7004728-9 1980 In rats on a high salt intake the total renin was low and was all in an active form. Salts 18-22 renin Rattus norvegicus 40-45 7449251-6 1980 The increase in plasma renin substrate level and production of renin substrate by the liver after nephrectomy was markedly suppressed by the treatment with PGE1 or PGE2. Alprostadil 156-160 renin Rattus norvegicus 63-68 7004730-8 1980 In renal perfusate only low-molecular-weight renin was found after renin stimulation by isoprenaline or anoxia. Isoproterenol 88-100 renin Rattus norvegicus 45-50 7449251-6 1980 The increase in plasma renin substrate level and production of renin substrate by the liver after nephrectomy was markedly suppressed by the treatment with PGE1 or PGE2. Dinoprostone 164-168 renin Rattus norvegicus 23-28 7449251-6 1980 The increase in plasma renin substrate level and production of renin substrate by the liver after nephrectomy was markedly suppressed by the treatment with PGE1 or PGE2. Dinoprostone 164-168 renin Rattus norvegicus 63-68 7004730-8 1980 In renal perfusate only low-molecular-weight renin was found after renin stimulation by isoprenaline or anoxia. Isoproterenol 88-100 renin Rattus norvegicus 67-72 7449251-10 1980 These findings suggest that PGE1 and PGE2 might be inhibitory factors in the regulation of renin substrate synthesis. Alprostadil 28-32 renin Rattus norvegicus 91-96 6775860-7 1980 8-Hydroxyquinoline appears the preferable enzyme inhibitor for renin assay in rat plasma. Oxyquinoline 0-18 renin Rattus norvegicus 63-68 7449251-10 1980 These findings suggest that PGE1 and PGE2 might be inhibitory factors in the regulation of renin substrate synthesis. Dinoprostone 37-41 renin Rattus norvegicus 91-96 7009165-0 1980 Efficacy of captopril in experimental low renin hypertension. Captopril 12-21 renin Rattus norvegicus 42-47 7009165-1 1980 Captopril (SQ 14225) had a clear antihypertensive effect in rat Heymann nephritis-DOCA-NaCl hypertension, a low renin model introduced recently, but was ineffective in 1-kidney-DOCA-NaCl hypertension although plasma renin activity (PRA) was suppressed similarly in both. Captopril 0-9 renin Rattus norvegicus 112-117 7009165-1 1980 Captopril (SQ 14225) had a clear antihypertensive effect in rat Heymann nephritis-DOCA-NaCl hypertension, a low renin model introduced recently, but was ineffective in 1-kidney-DOCA-NaCl hypertension although plasma renin activity (PRA) was suppressed similarly in both. Captopril 0-9 renin Rattus norvegicus 216-221 7000506-5 1980 However, beta-adrenergic blockade with propranolol completely prevented the renin response without altering the rise in vasopressin. Propranolol 39-50 renin Rattus norvegicus 76-81 7017211-0 1980 Effects of long-term treatments with captopril on blood pressure and renin activity in the stroke-prone spontaneously hypertensive rats. Captopril 37-46 renin Rattus norvegicus 69-74 7004910-0 1980 [Interaction of catecholamines and the renin-angiotensin system in regulating sodium reabsorption in the rat kidney]. Sodium 78-84 renin Rattus norvegicus 39-44 7014832-0 1980 Mechanism by which renin secretion from perfused rat kidneys is stimulated by isoprenaline and inhibited by high perfusion pressure. Isoproterenol 78-90 renin Rattus norvegicus 19-24 7004910-1 1980 It has been established that the catecholamine-induced increase in renin secretion by juxtaglomerular apparatus cells and sodium reabsorption stimulation in the rat kidney are consequent on the excitation of renal beta-adrenoreceptors. Catecholamines 33-46 renin Rattus norvegicus 67-72 7004910-2 1980 Strophanthin K interferes with the renin-secreting action of adrenaline and perverts its activating effect on sodium transport by renal tubules. strophanthin K 0-14 renin Rattus norvegicus 35-40 7004910-2 1980 Strophanthin K interferes with the renin-secreting action of adrenaline and perverts its activating effect on sodium transport by renal tubules. Epinephrine 61-71 renin Rattus norvegicus 35-40 7004910-3 1980 When given in a dose inhibiting angiotensin II formation and renin-secreting effect of catecholamines, heparin also diminishes their activating effect on tubular sodium transport. Catecholamines 87-101 renin Rattus norvegicus 61-66 7004910-3 1980 When given in a dose inhibiting angiotensin II formation and renin-secreting effect of catecholamines, heparin also diminishes their activating effect on tubular sodium transport. Heparin 103-110 renin Rattus norvegicus 61-66 7004910-4 1980 It is suggested that the renin-angiotensin system may be directly involved into the mechanism of catecholamine-stimulated sodium reabsorption by the rat kidney. Catecholamines 97-110 renin Rattus norvegicus 25-30 7004910-4 1980 It is suggested that the renin-angiotensin system may be directly involved into the mechanism of catecholamine-stimulated sodium reabsorption by the rat kidney. Sodium 122-128 renin Rattus norvegicus 25-30 7014832-4 1980 Isoprenaline (2.43 microM) stimulated renin secretion, but K-free medium and ouabain also reduced perfusate flow. Isoproterenol 0-12 renin Rattus norvegicus 38-43 7014832-23 1980 These observations suggest that isoprenaline stimulates renin secretion by a mechanism coupled to the Na-K pump. Isoproterenol 32-44 renin Rattus norvegicus 56-61 7418734-3 1980 Etilefrine, tyramine, ephedrine and REN-293 were all found to increase the efflux of 3H-noradrenaline and/or 3H-DOPEG to different degrees from the artery. 3h-noradrenaline 85-101 renin Rattus norvegicus 36-39 7418734-3 1980 Etilefrine, tyramine, ephedrine and REN-293 were all found to increase the efflux of 3H-noradrenaline and/or 3H-DOPEG to different degrees from the artery. 3h-dopeg 109-117 renin Rattus norvegicus 36-39 7000955-0 1980 Increased sodium appetite in adrenalectomized or hypophysectomized rats after intracranial injections of renin or angiotensin II. Sodium 10-16 renin Rattus norvegicus 105-110 6893397-3 1980 Administration of 0.15 mL/100 g/day CH2Cl2 to SHRs for five days reduced the BP from 172 +/- 7 mm Hg (mean +/- SEM) to 155 +/- 6 mm Hg without changing the plasma renin activity. Methylene Chloride 36-42 renin Rattus norvegicus 163-168 7000955-1 1980 Rats given free access to food, water and 2.7% NaCl and injected with either renin or angiotensin II into the preoptic area showed an immediate increase in water intake followed by an increase in intake of 2.7% NaCl. Water 156-161 renin Rattus norvegicus 77-82 7000955-1 1980 Rats given free access to food, water and 2.7% NaCl and injected with either renin or angiotensin II into the preoptic area showed an immediate increase in water intake followed by an increase in intake of 2.7% NaCl. Sodium Chloride 211-215 renin Rattus norvegicus 77-82 7000955-3 1980 Bilateral adrenalectomy had no effect on either the initial water intake or the delayed intake of NaCl that was induced by intracranial injections of renin or angiotensin II. Sodium Chloride 98-102 renin Rattus norvegicus 150-155 7000955-4 1980 However, the increased water intake during the 18 h after the administration of renin was reduced to normal levels in adrenalectomized rats. Water 23-28 renin Rattus norvegicus 80-85 7000955-6 1980 These results demonstrated that the delayed sodium appetite induced by renin or angiotensin II is not secondary to the stimulation of release of hormones from the pituitary gland or adrenal cortex. Sodium 44-50 renin Rattus norvegicus 71-76 6157960-0 1980 Synthesis and renin inhibitory properties of a new soluble pepstatin derivative. pepstatin 59-68 renin Rattus norvegicus 14-19 6252558-0 1980 Role of prostaglandins, beta-adrenoceptors, and the central nervous system in the control of renin release in conscious sodium-depleted rats. Prostaglandins 8-22 renin Rattus norvegicus 93-98 7000074-0 1980 Purification of rat renal renin from crude kidney extracts by diaminohexamethylene-sepharose chromatography. diaminohexamethylene 62-82 renin Rattus norvegicus 26-31 7000074-0 1980 Purification of rat renal renin from crude kidney extracts by diaminohexamethylene-sepharose chromatography. Sepharose 83-92 renin Rattus norvegicus 26-31 6998867-1 1980 The subcellular distribution and nature of rat renal renin has been investigated by means of analytical subcellular fractionation and gel filtration on Sephadex G-100. sephadex 152-166 renin Rattus norvegicus 53-58 6998867-3 1980 On sucrose gradient centrifugation in either a conventional or in a B XIV zonal rotor, renin activity equilibrated at 1.54 M sucrose and was partially resolved from marker enzymes for mitochondria (succinate dehydrogenase), lysosomes (acid phosphatase), plasma membranes (alkaline phosphatase), and peroxisomes (catalase). Sucrose 3-10 renin Rattus norvegicus 87-92 6998867-3 1980 On sucrose gradient centrifugation in either a conventional or in a B XIV zonal rotor, renin activity equilibrated at 1.54 M sucrose and was partially resolved from marker enzymes for mitochondria (succinate dehydrogenase), lysosomes (acid phosphatase), plasma membranes (alkaline phosphatase), and peroxisomes (catalase). Sucrose 125-132 renin Rattus norvegicus 87-92 6998867-4 1980 On gel filtration of the soluble or extracts of the renin-granular fractions on Sephadex G-100, renin activity eluted as a single peak with an apparent molecular weight (MW) of 42,000; no change in activity was found when these fractions were acidified to pH 3.0. sephadex 80-94 renin Rattus norvegicus 96-101 6157960-1 1980 A new pepstatin derivative, pepstatinyl arginine methyl ester hydrochloride (pepstatinyl-Arg-O-Me), was synthesized with the aim of increasing water solubility without altering capacity to inhibit the renin-angiotensinogen reaction. pepstatin 6-15 renin Rattus norvegicus 201-206 6998867-5 1980 When kidney homogenates were prepared in the presence of the proteolytic inhibitor N-ethylmaleimide (NEM, 10 mM), whereas the renin from the granular fractions displayed a MW of 44,000, that from the soluble fraction was apparently higher (69,000). Ethylmaleimide 83-99 renin Rattus norvegicus 126-131 6157960-1 1980 A new pepstatin derivative, pepstatinyl arginine methyl ester hydrochloride (pepstatinyl-Arg-O-Me), was synthesized with the aim of increasing water solubility without altering capacity to inhibit the renin-angiotensinogen reaction. pepstatinyl arginine methyl ester hydrochloride 28-75 renin Rattus norvegicus 201-206 6160366-0 1980 Effects of papaverine on basal and on isoproterenol-stimulated renin secretion from rat kidney slices. Isoproterenol 38-51 renin Rattus norvegicus 63-68 6157960-2 1980 Pepstatinyl-Arg-O-Me was shown to inhibit in vitro the reaction between either rat or purified hog renin and the natural rat renin substrate. pepstatinyl-arg-o-me 0-20 renin Rattus norvegicus 99-104 6157960-2 1980 Pepstatinyl-Arg-O-Me was shown to inhibit in vitro the reaction between either rat or purified hog renin and the natural rat renin substrate. pepstatinyl-arg-o-me 0-20 renin Rattus norvegicus 125-130 6157960-3 1980 In a fluorimetric assay, this derivative competitively inhibited the reaction between purified hog renin and a synthetic N-acetyl-tetradecapeptide renin substrate with a Ki of the same order of magnitude as that of pepstatin. Nitrogen 121-122 renin Rattus norvegicus 99-104 6157960-3 1980 In a fluorimetric assay, this derivative competitively inhibited the reaction between purified hog renin and a synthetic N-acetyl-tetradecapeptide renin substrate with a Ki of the same order of magnitude as that of pepstatin. Nitrogen 121-122 renin Rattus norvegicus 147-152 6157960-3 1980 In a fluorimetric assay, this derivative competitively inhibited the reaction between purified hog renin and a synthetic N-acetyl-tetradecapeptide renin substrate with a Ki of the same order of magnitude as that of pepstatin. Cysteine 123-130 renin Rattus norvegicus 99-104 6157960-3 1980 In a fluorimetric assay, this derivative competitively inhibited the reaction between purified hog renin and a synthetic N-acetyl-tetradecapeptide renin substrate with a Ki of the same order of magnitude as that of pepstatin. Cysteine 123-130 renin Rattus norvegicus 147-152 6157960-3 1980 In a fluorimetric assay, this derivative competitively inhibited the reaction between purified hog renin and a synthetic N-acetyl-tetradecapeptide renin substrate with a Ki of the same order of magnitude as that of pepstatin. pepstatin 215-224 renin Rattus norvegicus 99-104 6995541-7 1980 A single oral dose of SQ 14225, an angiotensin I-converting enzyme inhibitor, reduced erythropoietin to undetectable levels in renin-injected female rats. Captopril 22-30 renin Rattus norvegicus 127-132 6157960-3 1980 In a fluorimetric assay, this derivative competitively inhibited the reaction between purified hog renin and a synthetic N-acetyl-tetradecapeptide renin substrate with a Ki of the same order of magnitude as that of pepstatin. pepstatin 215-224 renin Rattus norvegicus 147-152 6157960-4 1980 In urethaneanesthetized ganglion-blocked rats, binephrectomized 24 hr before the experiments, both the plasma reinin concentration and the rise in blood pressure following intravenous injection of hog renin were inhibited by pepstatinyl-Arg-O-Me disappeared within 60 min. urethaneanesthetized 3-23 renin Rattus norvegicus 201-206 6157960-4 1980 In urethaneanesthetized ganglion-blocked rats, binephrectomized 24 hr before the experiments, both the plasma reinin concentration and the rise in blood pressure following intravenous injection of hog renin were inhibited by pepstatinyl-Arg-O-Me disappeared within 60 min. pepstatinyl-arg-o-me 225-245 renin Rattus norvegicus 201-206 6995574-0 1980 Biphasic effect of extracellular [K] on isoproterenol-stimulated renin secretion from rat kidney slices. Isoproterenol 40-53 renin Rattus norvegicus 65-70 6157960-7 1980 Pepstatinyl-Arg-Op-Me inhibited the reaction of endogenous and exogenous renin with plasma substrate both in vitro and in vivo. pepstatinyl-arg-op-me 0-21 renin Rattus norvegicus 73-78 6995574-3 1980 Increases in [k] (from 4-45 or to 60mM) inhibited basal and isoproterenol-stimulated renin secretion, independently of changes in [Na], [Cl] and osmolality. Isoproterenol 60-73 renin Rattus norvegicus 85-90 7001256-0 1980 Influence of streptozotocin-induced diabetes on blood pressure and on renin formation and release. Streptozocin 13-27 renin Rattus norvegicus 70-75 7001256-9 1980 The renal cortical renin concentration was much lower than in controls 42 days after either dose of streptozotocin, while the plasma renin activity was normal (40 mg/kg) or increased 65 mg/kg). Streptozocin 100-114 renin Rattus norvegicus 19-24 7002082-0 1980 Inhibition of hydralazine-induced renin release by indomethacin in the rat. Hydralazine 14-25 renin Rattus norvegicus 34-39 7002082-4 1980 Indomethacin inhibited this hydralazine-induced renin release by 100% at the 1 mg/kg dose and 36% at the 10 mg/kg dose even though the hypotensive effect of the drug was unaltered. Indomethacin 0-12 renin Rattus norvegicus 48-53 7002082-4 1980 Indomethacin inhibited this hydralazine-induced renin release by 100% at the 1 mg/kg dose and 36% at the 10 mg/kg dose even though the hypotensive effect of the drug was unaltered. Hydralazine 28-39 renin Rattus norvegicus 48-53 7002082-3 1980 Hydralazine increased the serum renin levels from 3.3 +/- 0.5 to 13.7 +/- 3.1 and 41.9 +/- 2.4 ng/ml/hr at the 1 and 10 mg/kg doses, respectively. Hydralazine 0-11 renin Rattus norvegicus 32-37 7002082-0 1980 Inhibition of hydralazine-induced renin release by indomethacin in the rat. Indomethacin 51-63 renin Rattus norvegicus 34-39 7002082-6 1980 The beta-blocker, propranolol, was as effective as indomethacin in attenuating hydralazine-induced renin release. Propranolol 18-29 renin Rattus norvegicus 99-104 7002082-6 1980 The beta-blocker, propranolol, was as effective as indomethacin in attenuating hydralazine-induced renin release. Indomethacin 51-63 renin Rattus norvegicus 99-104 7002082-1 1980 Renal prostaglandins (PG) appear to mediate the release of renin due to activation of the intrarenal baroreceptor and stimulation of the renal sympathetic nerves. Prostaglandins 6-20 renin Rattus norvegicus 59-64 7002082-6 1980 The beta-blocker, propranolol, was as effective as indomethacin in attenuating hydralazine-induced renin release. Hydralazine 79-90 renin Rattus norvegicus 99-104 7002082-1 1980 Renal prostaglandins (PG) appear to mediate the release of renin due to activation of the intrarenal baroreceptor and stimulation of the renal sympathetic nerves. Prostaglandins 22-24 renin Rattus norvegicus 59-64 7002082-9 1980 Thus, renal PG"s appear to be important as mediators of hydralazine-stimulated renin release but no hydralazine-induced vasodilatation. Hydralazine 56-67 renin Rattus norvegicus 79-84 7002082-2 1980 Since the vasodilator hydralazine is thought to stimulate renin release by both of these mechanisms, we examined the effect of indomethacin, a PG synthetase inhibitor, on hydralazine-induced renin release. Hydralazine 22-33 renin Rattus norvegicus 58-63 7002082-2 1980 Since the vasodilator hydralazine is thought to stimulate renin release by both of these mechanisms, we examined the effect of indomethacin, a PG synthetase inhibitor, on hydralazine-induced renin release. Indomethacin 127-139 renin Rattus norvegicus 191-196 7002082-2 1980 Since the vasodilator hydralazine is thought to stimulate renin release by both of these mechanisms, we examined the effect of indomethacin, a PG synthetase inhibitor, on hydralazine-induced renin release. Hydralazine 171-182 renin Rattus norvegicus 191-196 6998621-0 1980 Renin secretion and renal vascular resistance following prolonged administration of desoxycorticosterone (DOC) in rats drinking normal saline. Desoxycorticosterone 84-104 renin Rattus norvegicus 0-5 7001469-4 1980 Mellitin was, however, a more potent activator of membrane-bound renin in the presence of calcium. Calcium 90-97 renin Rattus norvegicus 65-70 6158822-0 1980 Role of the renin-angiotensin system in the adaptation of aldosterone biosynthesis to sodium restriction in the rat. Aldosterone 58-69 renin Rattus norvegicus 12-17 6158822-0 1980 Role of the renin-angiotensin system in the adaptation of aldosterone biosynthesis to sodium restriction in the rat. Sodium 86-92 renin Rattus norvegicus 12-17 6158822-1 1980 The purpose of the present study was to evaluate the role of the renin-angiotensin system in the secretion of aldosterone during restriction of dietary sodium intake. Aldosterone 110-121 renin Rattus norvegicus 65-70 6158822-1 1980 The purpose of the present study was to evaluate the role of the renin-angiotensin system in the secretion of aldosterone during restriction of dietary sodium intake. Sodium 152-158 renin Rattus norvegicus 65-70 6158822-9 1980 Plasma renin activity was increased both by sodium depletion and CEI. Sodium 44-50 renin Rattus norvegicus 7-12 6998621-0 1980 Renin secretion and renal vascular resistance following prolonged administration of desoxycorticosterone (DOC) in rats drinking normal saline. Desoxycorticosterone 106-109 renin Rattus norvegicus 0-5 6998621-4 1980 Renin secretion rate and peripheral plasma renin activity was markedly reduced in the DOC-saline treated rats. Desoxycorticosterone 86-89 renin Rattus norvegicus 0-5 6998621-4 1980 Renin secretion rate and peripheral plasma renin activity was markedly reduced in the DOC-saline treated rats. Desoxycorticosterone 86-89 renin Rattus norvegicus 43-48 6998621-10 1980 These findings indicate that suppression of renin secretion during prolonged DOC-saline administration cannot be directly attributed to changes in arterial pressure, renal vascular resistance or beta-adrenoceptor sensitivity. Desoxycorticosterone 77-80 renin Rattus norvegicus 44-49 6244927-0 1980 Prostaglandin stimulation of renin release: independence of beta-adrenergic receptor activity and possible mechanism of action. Prostaglandins 0-13 renin Rattus norvegicus 29-34 7003099-0 1980 Effect of D-600 on inhibition of in vitro renin release in the rat by high extracellular potassium and angiotensin II. Gallopamil 10-15 renin Rattus norvegicus 42-47 7003099-2 1980 Renin was secreted by rat renal cortical slices incubated at 37 degrees C in a physiological saline solution. Sodium Chloride 93-99 renin Rattus norvegicus 0-5 7003100-0 1980 Studies on the mechanism of renin release from rat kidney slices: calcium, sodium and metabolic inhibition. Calcium 66-73 renin Rattus norvegicus 28-33 7003100-0 1980 Studies on the mechanism of renin release from rat kidney slices: calcium, sodium and metabolic inhibition. Sodium 75-81 renin Rattus norvegicus 28-33 7003100-4 1980 Ouabain significantly inhibited renin release in calcium containing medium, but had no effect on LDH release. Calcium 49-56 renin Rattus norvegicus 32-37 7003100-5 1980 Renin release was potentiated in calcium ;free" media, while calcium depletion reduced the release of LDH.3. Calcium 33-40 renin Rattus norvegicus 0-5 7003100-6 1980 The addition of potassium cyanide (2 mM) significantly inhibited the release of renin from these tissue slices. Potassium Cyanide 16-33 renin Rattus norvegicus 80-85 7003100-9 1980 Medium sodium depletion caused a significant inhibition of renin release. Sodium 7-13 renin Rattus norvegicus 59-64 7003100-12 1980 On the other hand, the in vitro release of renin during these experiments appeared to be inversely related to the intracellular concentration of calcium. Calcium 145-152 renin Rattus norvegicus 43-48 6995929-5 1980 These data indicate a critical role of renin in the rise of blood pressure and water intake after initial application of a renal artery clip as well as after reapplication of the clip to declipped rats. Water 79-84 renin Rattus norvegicus 39-44 7377376-1 1980 Activation of the renin-angiotensin system (RAS) or administration of angiotensin II (AII) will induce water intake. Water 103-108 renin Rattus norvegicus 18-23 6997093-13 1980 Thus, it is suggested that the increases in PRA, PRC and RRC in the captopril rats may be related to both the blood pressure reduction and interruption of the negative feedback inhibition of renin synthesis and release by AII, and that the decrease in PRS in the captopril rats is due to the increased consumption and probably to the decreased rate of substrate production in the liver which is secondary to the decrease in plasma AII. Captopril 68-77 renin Rattus norvegicus 191-196 6992601-5 1980 The low-sodium diet increased plasma renin activity to about the same level in one- and two-kidney normotensive rats. Sodium 8-14 renin Rattus norvegicus 37-42 6992601-6 1980 However, the increase in plasma renin activity elicited by dietary sodium restriction was markedly less in one-kidney Goldblatt hypertension. Sodium 67-73 renin Rattus norvegicus 32-37 7004912-0 1980 Effect of subcutaneous injections of carbuterol on renin release and water intake in the rat. carbuterol 37-47 renin Rattus norvegicus 51-56 7004912-2 1980 Carbuterol, as well as isoprenaline, elicited a clear dipsogenic effect, dose-dependent, apparently mediated by stimulation of the renin-angiotensin system. carbuterol 0-10 renin Rattus norvegicus 131-136 7004912-2 1980 Carbuterol, as well as isoprenaline, elicited a clear dipsogenic effect, dose-dependent, apparently mediated by stimulation of the renin-angiotensin system. Isoproterenol 23-35 renin Rattus norvegicus 131-136 6244927-1 1980 Using a continuous superfusion system of rat kidney cortical slices, we investigated the renin-releasing effect of prostaglandin E2 (PGE2) and its possible mechanism of action. Dinoprostone 115-131 renin Rattus norvegicus 89-94 6244927-1 1980 Using a continuous superfusion system of rat kidney cortical slices, we investigated the renin-releasing effect of prostaglandin E2 (PGE2) and its possible mechanism of action. Dinoprostone 133-137 renin Rattus norvegicus 89-94 6244927-2 1980 PGE2 caused significant stimulation of renin release in a dose-dependent fashion at concentrations of 3 x 10(-6) to 10(-4) M. Isoproterenol (8 x 10(-7) M) stimulated renin release significantly, and its effect was completely abolished by propranolol (2 x 10(-5) M). Dinoprostone 0-4 renin Rattus norvegicus 39-44 6988533-4 1980 After 5 months the PRA was significantly higher in the lead-treated group even on a 1% NaCl diet, but the difference between groups disappeared on an Na-free diet; that is, the renin response to sodium deprivation was blunted. Sodium 195-201 renin Rattus norvegicus 177-182 6244927-2 1980 PGE2 caused significant stimulation of renin release in a dose-dependent fashion at concentrations of 3 x 10(-6) to 10(-4) M. Isoproterenol (8 x 10(-7) M) stimulated renin release significantly, and its effect was completely abolished by propranolol (2 x 10(-5) M). Dinoprostone 0-4 renin Rattus norvegicus 166-171 6997455-0 1980 Hypotensive effect of captopril in relation to plasma renin activity in anesthetized rats. Captopril 22-31 renin Rattus norvegicus 54-59 6244927-2 1980 PGE2 caused significant stimulation of renin release in a dose-dependent fashion at concentrations of 3 x 10(-6) to 10(-4) M. Isoproterenol (8 x 10(-7) M) stimulated renin release significantly, and its effect was completely abolished by propranolol (2 x 10(-5) M). Isoproterenol 126-139 renin Rattus norvegicus 39-44 6997455-4 1980 Individual values for the hypotensive effect produced by captopril and plasma renin activity obtained just before injection of captopril showed a highly significant correlation. Captopril 127-136 renin Rattus norvegicus 78-83 6244927-2 1980 PGE2 caused significant stimulation of renin release in a dose-dependent fashion at concentrations of 3 x 10(-6) to 10(-4) M. Isoproterenol (8 x 10(-7) M) stimulated renin release significantly, and its effect was completely abolished by propranolol (2 x 10(-5) M). Isoproterenol 126-139 renin Rattus norvegicus 166-171 6244927-2 1980 PGE2 caused significant stimulation of renin release in a dose-dependent fashion at concentrations of 3 x 10(-6) to 10(-4) M. Isoproterenol (8 x 10(-7) M) stimulated renin release significantly, and its effect was completely abolished by propranolol (2 x 10(-5) M). Propranolol 238-249 renin Rattus norvegicus 39-44 6244927-3 1980 PGE2-stimulated renin release was not blocked by the same dose of propranolol. Dinoprostone 0-4 renin Rattus norvegicus 16-21 6244927-4 1980 Dibutyryl cAMP caused a dose-dependent increase in renin release at concentrations of 10(-5) to 5 x 10(-3) M. Theophylline (4 x 10(-3) M) had no effect on renin release, but when added to subthreshold doses of PGE2 (10(-6) M), it stimulated renin release significantly. dibutyryl 0-9 renin Rattus norvegicus 51-56 6248654-2 1980 On the sodium loading, the blood pressure increased gradually and plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were decreased. Sodium 7-13 renin Rattus norvegicus 73-78 6244927-4 1980 Dibutyryl cAMP caused a dose-dependent increase in renin release at concentrations of 10(-5) to 5 x 10(-3) M. Theophylline (4 x 10(-3) M) had no effect on renin release, but when added to subthreshold doses of PGE2 (10(-6) M), it stimulated renin release significantly. Cyclic AMP 10-14 renin Rattus norvegicus 51-56 6995690-7 1980 These results indicate that changes in fractional renin release are induced by sodium balance variation, and these changes are preserved in vitro only in sodium-loaded states. Sodium 79-85 renin Rattus norvegicus 50-55 6995690-7 1980 These results indicate that changes in fractional renin release are induced by sodium balance variation, and these changes are preserved in vitro only in sodium-loaded states. Sodium 154-160 renin Rattus norvegicus 50-55 6244927-4 1980 Dibutyryl cAMP caused a dose-dependent increase in renin release at concentrations of 10(-5) to 5 x 10(-3) M. Theophylline (4 x 10(-3) M) had no effect on renin release, but when added to subthreshold doses of PGE2 (10(-6) M), it stimulated renin release significantly. Dinoprostone 210-214 renin Rattus norvegicus 51-56 6244927-6 1980 These experiments show that PGE2 causes stimulation of renin release by a direct effect on the JG cell. Dinoprostone 28-32 renin Rattus norvegicus 55-60 6244927-7 1980 The renin-releasing effect of PGE2 does not depend upon the beta-adrenergic receptors but may be mediated through cAMP. Dinoprostone 30-34 renin Rattus norvegicus 4-9 6244927-7 1980 The renin-releasing effect of PGE2 does not depend upon the beta-adrenergic receptors but may be mediated through cAMP. Cyclic AMP 114-118 renin Rattus norvegicus 4-9 6245897-7 1980 It is suggested that besides its inhibitory action on ACE, captopril has a direct or indirect stimulating action on ACE production as well as on renin release. Captopril 59-68 renin Rattus norvegicus 145-150 6996017-1 1980 The effects of intravenous injection of prostacyclin (PGI2) and two of its analogues with modified omega-side chain on systemic blood pressure and on plasma renin activity were investigated in anesthetized rats. Epoprostenol 40-52 renin Rattus norvegicus 157-162 6996017-3 1980 Despite these equipotent effects on blood pressure a marked difference between PGI2 and the analogues with respect to stimulation of plasma renin activity could be demonstrated. Epoprostenol 79-83 renin Rattus norvegicus 140-145 6996017-4 1980 The cyclohexyl as well as the 3-thienyloxymethyl analogue induced a significantly stronger increase of plasma renin activity than PGI2. 3-thienyloxymethyl 30-48 renin Rattus norvegicus 110-115 6996017-5 1980 These findings strengthen the view of a direct involvement of prostacyclins in renin release mechanisms. Prostaglandins I 62-75 renin Rattus norvegicus 79-84 6244391-0 1980 Vanadate inhibits renin secretion from rat kidney slices. Vanadates 0-8 renin Rattus norvegicus 18-23 6993760-0 1980 Intrarenal renin, angiotensin II, and plasma renin in rats with uranyl nitrate-induced and glycerol-induced acute renal failure. Uranyl Nitrate 64-78 renin Rattus norvegicus 45-50 7411436-0 1980 Increased sodium appetite in the rat induced by intracranial administration of components of the renin-angiotensin system. Sodium 10-16 renin Rattus norvegicus 97-102 7411436-2 1980 Intracranial injections of components of the renin-angiotensin system in rats in normal water and Na balance caused an immediate thirst followed by a progressive increase in Na appetite during a test session which lasted 18 h. The effect on water and Na intake was dose-dependent. Water 88-93 renin Rattus norvegicus 45-50 7411436-2 1980 Intracranial injections of components of the renin-angiotensin system in rats in normal water and Na balance caused an immediate thirst followed by a progressive increase in Na appetite during a test session which lasted 18 h. The effect on water and Na intake was dose-dependent. Water 241-246 renin Rattus norvegicus 45-50 6991407-7 1980 These results indicate that captopril and saralasin lower blood pressure in the SHR by some mechanism(s) independent of the kidneys, circulating renin, or bradykinin potentiation. Captopril 28-37 renin Rattus norvegicus 145-150 6991669-0 1980 Separate and combined effects of ouabain and extracellular potassium on renin secretion from rat renal cortical slices. Potassium 59-68 renin Rattus norvegicus 72-77 6991669-2 1980 Renin secretion of rat renal cortical slices was measured as a function of extracellular K and ouabain concentrations in the incubation medium.2. Ouabain 95-102 renin Rattus norvegicus 0-5 6990424-3 1980 One hour after ethanol loading (4.8 g/kg, by stomach tube), plasma renin activity of AA rats was four times as high as in ANA rats. Ethanol 15-22 renin Rattus norvegicus 67-72 6990424-5 1980 The strain differences in voluntary salt intake and salt metabolism may modulate the consumption of calories and water as well as blood pressure and different reactivity of the renin system in AA and ANA rats. Salts 36-40 renin Rattus norvegicus 177-182 6990424-5 1980 The strain differences in voluntary salt intake and salt metabolism may modulate the consumption of calories and water as well as blood pressure and different reactivity of the renin system in AA and ANA rats. Salts 52-56 renin Rattus norvegicus 177-182 6993603-0 1980 Effects of insulin and glucagon on production of renin substrate by the isolated rat liver. Glucagon 23-31 renin Rattus norvegicus 49-54 6988009-5 1980 Renin activity in the fractions from Sephadex G-100 chromatography was increased 70% by dialysis at acid as well as neutral pH through the whole molecular weight range. sephadex 37-51 renin Rattus norvegicus 0-5 7352670-1 1980 The role of the renin--angiotensin system in the maintenance of blood pressure during halothane anesthesia and sodium nitroprusside (SNP)-induced hypotension was evaluated. Halothane 86-95 renin Rattus norvegicus 16-21 7352670-8 1980 This demonstrates the participation of the renin--angiotensin system in antagonizing the combined hypotensive effects of halothane and SNP. Halothane 121-130 renin Rattus norvegicus 43-48 6991666-0 1980 Renin release from isolated rat glomeruli: effects of colchicine, vinca alkaloids, dimethylsulphoxide, and cytochalasins. Vinca Alkaloids 66-81 renin Rattus norvegicus 0-5 6991666-0 1980 Renin release from isolated rat glomeruli: effects of colchicine, vinca alkaloids, dimethylsulphoxide, and cytochalasins. Dimethyl Sulfoxide 83-101 renin Rattus norvegicus 0-5 6991666-0 1980 Renin release from isolated rat glomeruli: effects of colchicine, vinca alkaloids, dimethylsulphoxide, and cytochalasins. Cytochalasins 107-120 renin Rattus norvegicus 0-5 6991666-4 1980 Colchicine (10(-3) M) had no effect, whereas vinblastine and vincristine (10(-5) M) caused a progressive increase in basal renin release from isolated glomeruli. Vinblastine 45-56 renin Rattus norvegicus 123-128 6991666-4 1980 Colchicine (10(-3) M) had no effect, whereas vinblastine and vincristine (10(-5) M) caused a progressive increase in basal renin release from isolated glomeruli. Vincristine 61-72 renin Rattus norvegicus 123-128 6991666-6 1980 After 60 min exposure to either colchicine or the vinca alkaloids, the first renin release response to a hypoosmotic challenge (reduction in sucrose or sodium chloride concentration) was depressed while that of the second (after 120 min exposure) was enhanced. Colchicine 32-42 renin Rattus norvegicus 77-82 6991666-6 1980 After 60 min exposure to either colchicine or the vinca alkaloids, the first renin release response to a hypoosmotic challenge (reduction in sucrose or sodium chloride concentration) was depressed while that of the second (after 120 min exposure) was enhanced. Vinca Alkaloids 50-65 renin Rattus norvegicus 77-82 6991666-6 1980 After 60 min exposure to either colchicine or the vinca alkaloids, the first renin release response to a hypoosmotic challenge (reduction in sucrose or sodium chloride concentration) was depressed while that of the second (after 120 min exposure) was enhanced. Sucrose 141-148 renin Rattus norvegicus 77-82 6991666-6 1980 After 60 min exposure to either colchicine or the vinca alkaloids, the first renin release response to a hypoosmotic challenge (reduction in sucrose or sodium chloride concentration) was depressed while that of the second (after 120 min exposure) was enhanced. Sodium Chloride 152-167 renin Rattus norvegicus 77-82 6991668-9 1980 Clonidine (10 muM) and oxymetazoline (10 muM) constricted the renal vasculature and stimulated renin release during high perfusate albumin concentration providing perfusion pressure was kept constant.6. Clonidine 0-9 renin Rattus norvegicus 95-100 6991668-9 1980 Clonidine (10 muM) and oxymetazoline (10 muM) constricted the renal vasculature and stimulated renin release during high perfusate albumin concentration providing perfusion pressure was kept constant.6. Oxymetazoline 23-36 renin Rattus norvegicus 95-100 6991668-10 1980 Low renal perfusion pressure (50 mmHg) and isoprenaline (2.43 muM) stimulated renin release in perfusion experiments with both 20 and 60 g/l., but the rate of renin release was substantially greater with 60 g/l.7. Isoproterenol 43-55 renin Rattus norvegicus 78-83 6991668-11 1980 On the other hand, perfusion fluid deprived of calcium induced a greater increase in renin release in kidneys perfused with 20 g/l. Calcium 47-54 renin Rattus norvegicus 85-90 6995653-0 1980 Effect of 3-hydrazino-6[N, N-bis (2-hydroxyethyl) amino]-pyridazine (L 6150) on renin in hypertensive rats. 3-hydrazino-6[n, n-bis (2-hydroxyethyl) amino]-pyridazine 10-67 renin Rattus norvegicus 80-85 6992788-4 1980 Penbutolol reduces basal plasma renin activity in the same dose range as does propranolol but is about 3 times stronger with respect to isoproterenol-induced increase of PRA. Penbutolol 0-10 renin Rattus norvegicus 32-37 6986793-0 1980 Cadmium and nickel influence on blood pressure, plasma renin, and tissue mineral concentrations. Cadmium 0-7 renin Rattus norvegicus 55-60 6986793-0 1980 Cadmium and nickel influence on blood pressure, plasma renin, and tissue mineral concentrations. Nickel 12-18 renin Rattus norvegicus 55-60 6986224-13 1980 Captopril lowers blood pressure in situations where the renin-angiotensin system is not responsible for blood pressure maintenance. Captopril 0-9 renin Rattus norvegicus 56-61 7418541-3 1980 The main purpose of the study was to find out how a reduction or an increase of total body sodium and the associated changes of renin production can influence the vascular response to angiotensin and to catecholamines. Sodium 91-97 renin Rattus norvegicus 128-133 7004806-1 1980 The effect of an oral angiotensin I converting enzyme inhibitor, SQ 14225 (Captopril) on blood pressure and plasma renin activity (PRA) was studied in deoxycorticosterone-salt (DOCA/salt) hypertensive rats. Captopril 65-73 renin Rattus norvegicus 115-120 6991209-5 1980 During sodium-depletion, blood pressure maintenance became renin-dependent; sodium-loading caused a decrease of renin-angiotensin activity in renovascular hypertension. Sodium 7-13 renin Rattus norvegicus 59-64 7418541-3 1980 The main purpose of the study was to find out how a reduction or an increase of total body sodium and the associated changes of renin production can influence the vascular response to angiotensin and to catecholamines. Catecholamines 203-217 renin Rattus norvegicus 128-133 6155322-4 1980 Both plasma and aortic renin (measured with an incubation pH of 6.5) rose in salt-depleted and fell in salt-loaded rats. Salts 77-81 renin Rattus norvegicus 23-28 6991209-5 1980 During sodium-depletion, blood pressure maintenance became renin-dependent; sodium-loading caused a decrease of renin-angiotensin activity in renovascular hypertension. Sodium 76-82 renin Rattus norvegicus 112-117 6991209-6 1980 A weak direct correlation between depressor response to saralasin and the plasma renin activity could be established in the different sodium-depleted and sodium-loaded states. Sodium 134-140 renin Rattus norvegicus 81-86 6991209-6 1980 A weak direct correlation between depressor response to saralasin and the plasma renin activity could be established in the different sodium-depleted and sodium-loaded states. Sodium 154-160 renin Rattus norvegicus 81-86 6991212-0 1980 Secretion of arginin-vasopressin, aldosterone and corticosterone and plasma-renin activity in water-deprived rats. Water 94-99 renin Rattus norvegicus 76-81 6155322-4 1980 Both plasma and aortic renin (measured with an incubation pH of 6.5) rose in salt-depleted and fell in salt-loaded rats. Salts 103-107 renin Rattus norvegicus 23-28 6993972-1 1980 These studies examined the effects of the volume expansion and the enhanced activity of the renin-angiotensin system during pregnancy on the severity of glycerol-induced myoglobinuric acute renal failure (ARF) in the rat. Glycerol 153-161 renin Rattus norvegicus 92-97 6762404-3 1980 Plasma renin concentrations decreased after injection of Althesin and thiopental but increased after injection of ketamine. Thiopental 70-80 renin Rattus norvegicus 7-12 6762404-3 1980 Plasma renin concentrations decreased after injection of Althesin and thiopental but increased after injection of ketamine. Ketamine 114-122 renin Rattus norvegicus 7-12 6102616-1 1980 Effects of dl-, d-, l-propranolol and pindolol on renin release. dl-, d-, l-propranolol 11-33 renin Rattus norvegicus 50-55 6102616-1 1980 Effects of dl-, d-, l-propranolol and pindolol on renin release. Pindolol 38-46 renin Rattus norvegicus 50-55 6102616-2 1980 In order to reveal the mechanism of renin inhibition by beta adrenergic blocking agents, the effects of dl-, d-, l-propranolol and pindolol on renin release were studied. Pindolol 131-139 renin Rattus norvegicus 143-148 6102616-4 1980 In the in vivo study, dl-, d-, and l-propranolol inhibited plasma renin activity and renal renin content significantly in normal rats. dl-, d-, and l-propranolol 22-48 renin Rattus norvegicus 66-71 6102616-4 1980 In the in vivo study, dl-, d-, and l-propranolol inhibited plasma renin activity and renal renin content significantly in normal rats. dl-, d-, and l-propranolol 22-48 renin Rattus norvegicus 91-96 6102616-6 1980 Pindolol also inhibited renin release, but its effects were significantly less than those of other agents. Pindolol 0-8 renin Rattus norvegicus 24-29 6101342-5 1980 Renin stimulation by both agonists was suppressed by propranolol (nonselective) and by acebutolol and its derivative M&B 16,942 (beta-1 selective antagonists). Propranolol 53-64 renin Rattus norvegicus 0-5 6101342-5 1980 Renin stimulation by both agonists was suppressed by propranolol (nonselective) and by acebutolol and its derivative M&B 16,942 (beta-1 selective antagonists). Acebutolol 87-97 renin Rattus norvegicus 0-5 6101342-5 1980 Renin stimulation by both agonists was suppressed by propranolol (nonselective) and by acebutolol and its derivative M&B 16,942 (beta-1 selective antagonists). Adenosine Monophosphate 119-122 renin Rattus norvegicus 0-5 7010370-1 1980 The efficacy of various prostaglandins to stimulate renin release was compared in the isolated perfused rat kidney. Prostaglandins 24-38 renin Rattus norvegicus 52-57 6997857-0 1980 Isolation of renin granules from rat kidney cortex by isotonic or hyperosmotic metrizamide-sucrose gradients. Metrizamide 79-90 renin Rattus norvegicus 13-18 6997857-0 1980 Isolation of renin granules from rat kidney cortex by isotonic or hyperosmotic metrizamide-sucrose gradients. Sucrose 91-98 renin Rattus norvegicus 13-18 6997808-0 1980 [Renin secretion by rat and rabbit kidneys under the influence of prostaglandins]. Prostaglandins 66-80 renin Rattus norvegicus 1-6 7010370-2 1980 Renin release was stimulated in decreasing order of potency by PGE2, PGE2, PGF2 alpha and PGI2, whereas PGA2, PGD2 and 6-keto-PGF1 alpha were without effect. Dinoprostone 63-67 renin Rattus norvegicus 0-5 7010370-2 1980 Renin release was stimulated in decreasing order of potency by PGE2, PGE2, PGF2 alpha and PGI2, whereas PGA2, PGD2 and 6-keto-PGF1 alpha were without effect. Dinoprostone 69-73 renin Rattus norvegicus 0-5 7010370-2 1980 Renin release was stimulated in decreasing order of potency by PGE2, PGE2, PGF2 alpha and PGI2, whereas PGA2, PGD2 and 6-keto-PGF1 alpha were without effect. Dinoprost 75-79 renin Rattus norvegicus 0-5 7010370-2 1980 Renin release was stimulated in decreasing order of potency by PGE2, PGE2, PGF2 alpha and PGI2, whereas PGA2, PGD2 and 6-keto-PGF1 alpha were without effect. Epoprostenol 90-94 renin Rattus norvegicus 0-5 7323421-4 1980 Prolonged, high-dose gentamicin administration caused a decrease in creatinine clearance, an increase in plasma renin activity and a corresponding decrease in the area available for filtration. Gentamicins 21-31 renin Rattus norvegicus 112-117 498442-0 1979 Effects of saline and mannitol on renin and distal tubule Na in rats. Mannitol 22-30 renin Rattus norvegicus 34-39 500824-3 1979 Indomethacin decreased the basal serum aldosterone levels by 50% and serum renin levels by 43%. Indomethacin 0-12 renin Rattus norvegicus 75-80 396069-2 1979 The effect of alpha-adrenergic stimulation, with phenylephrine, on isoprenaline-provoked renin secretion was studied in the isolated perfused rat kidney. Phenylephrine 49-62 renin Rattus norvegicus 89-94 396069-2 1979 The effect of alpha-adrenergic stimulation, with phenylephrine, on isoprenaline-provoked renin secretion was studied in the isolated perfused rat kidney. Isoproterenol 67-79 renin Rattus norvegicus 89-94 396069-4 1979 Infusion of phenylephrine increased renal perfusion pressure and prevented renin secretion in response to isoprenaline. Phenylephrine 12-25 renin Rattus norvegicus 75-80 396069-4 1979 Infusion of phenylephrine increased renal perfusion pressure and prevented renin secretion in response to isoprenaline. Isoproterenol 106-118 renin Rattus norvegicus 75-80 396069-6 1979 Renal vasoconstriction was abolished and the response in renin secretion to isoprenaline was restored by alpha-adrenoreceptor blockade with phenoxybenzamine. Isoproterenol 76-88 renin Rattus norvegicus 57-62 396069-6 1979 Renal vasoconstriction was abolished and the response in renin secretion to isoprenaline was restored by alpha-adrenoreceptor blockade with phenoxybenzamine. Phenoxybenzamine 140-156 renin Rattus norvegicus 57-62 396069-8 1979 In contrast, when renal vasoconstriction was prevented by dihydrallazine, suppression of renin release by phenylephrine still occurred. Dihydralazine 58-72 renin Rattus norvegicus 89-94 396069-8 1979 In contrast, when renal vasoconstriction was prevented by dihydrallazine, suppression of renin release by phenylephrine still occurred. Phenylephrine 106-119 renin Rattus norvegicus 89-94 500824-5 1979 In contrast, meclofenamate failed to alter basal serum levels of aldosterone or AII-stimulated aldosterone release but inhibited serum renin levels by 27% and the aldosterone-stimulating effect of AIII by 99%. Meclofenamic Acid 13-26 renin Rattus norvegicus 135-140 396073-8 1979 The injection of a mixture of renin and kallikrein attenuated the effect of renin alone, indicating that both enzymes exert antagonistic actions on the excretion of electrolytes and water by the kidneys. Water 182-187 renin Rattus norvegicus 30-35 500824-11 1979 The present findings suggest that prostaglandins modulate the effects of the renin-angiotensin system by stimulating the release of renin from the kidney and augmenting the steroidogenic effects of AII and AIII in the adrenal cortex. Prostaglandins 34-48 renin Rattus norvegicus 77-82 396073-10 1979 A purified fraction of kidney extract containing no kallikrein and only traces of renin activity, had a stimulatory effect on kallikrein, water and electrolyte excretion. Water 138-143 renin Rattus norvegicus 82-87 500824-11 1979 The present findings suggest that prostaglandins modulate the effects of the renin-angiotensin system by stimulating the release of renin from the kidney and augmenting the steroidogenic effects of AII and AIII in the adrenal cortex. Prostaglandins 34-48 renin Rattus norvegicus 132-137 512921-0 1979 Phenytoin stimulates renin secretion from rat kidney slices. Phenytoin 0-9 renin Rattus norvegicus 21-26 512921-1 1979 Phenytoin stimulated renin secretion from rat renal cortical slices. Phenytoin 0-9 renin Rattus norvegicus 21-26 227278-0 1979 Effect of sodium restriction on plasma renin activity and renin granules in rat kidney. Sodium 10-16 renin Rattus norvegicus 39-44 390537-0 1979 The effects of captopril, propranolol, and indomethacin on blood pressure and plasma renin activity in spontaneously hypertensive and normotensive rats. Indomethacin 43-55 renin Rattus norvegicus 85-90 396613-2 1979 Perfusion with low sodium buffer (110 mM/l) produced a significant increase in renin secretion compared with control experiments (Na+:135 mM/l). Sodium 19-25 renin Rattus norvegicus 79-84 396613-3 1979 Since the presence of tubules seems necessary for such an effect to take place, it suggests that the high renin secretion stimulated by a low sodium buffer centers in the Macula densa. Sodium 142-148 renin Rattus norvegicus 106-111 396613-4 1979 Perfusion with high sodium buffer (170 mM/l; osmolarity 350 mOs/l) induces a stimulation on renin release. Sodium 20-26 renin Rattus norvegicus 92-97 396613-5 1979 However, a greater rise in renin is achieved in control experiments if choline chloride increases the osmolarity from 300 to 350 mOs/l. Choline 71-87 renin Rattus norvegicus 27-32 396613-6 1979 All this suggests that high sodium buffer, independently of its osmotic effect, has an inhibitory role on renin release. Sodium 28-34 renin Rattus norvegicus 106-111 227278-0 1979 Effect of sodium restriction on plasma renin activity and renin granules in rat kidney. Sodium 10-16 renin Rattus norvegicus 58-63 227278-1 1979 The present study was carried out to procure detailed information on the relationship between chronic sodium restriction and renin content of kidneys at a subcellular level in the rat. Sodium 102-108 renin Rattus norvegicus 125-130 227278-5 1979 Low sodium intake for 4 wk resulted in a 12.4-fold increase in plasma renin activity and led to a 2.6-fold increase in renin activity of the RG fraction. Sodium 4-10 renin Rattus norvegicus 70-75 227278-5 1979 Low sodium intake for 4 wk resulted in a 12.4-fold increase in plasma renin activity and led to a 2.6-fold increase in renin activity of the RG fraction. Sodium 4-10 renin Rattus norvegicus 119-124 227278-7 1979 These results provide evidence for increased renin activity in storage granules following chronic sodium restriction. Sodium 98-104 renin Rattus norvegicus 45-50 230829-1 1979 The present study attempts to determine if the isolated rat liver is capable of synthesizing renin substrate from 14C-labelled amino acids added in the perfusate. Carbon-14 114-117 renin Rattus norvegicus 93-98 41729-3 1979 Concentrations of noradrenaline, adrenaline and methoxamine of 10(-6), 10(-5), 10(-4) and 10(-3) M caused significant dose-related inhibition of renin release. Norepinephrine 18-31 renin Rattus norvegicus 145-150 41729-3 1979 Concentrations of noradrenaline, adrenaline and methoxamine of 10(-6), 10(-5), 10(-4) and 10(-3) M caused significant dose-related inhibition of renin release. Epinephrine 21-31 renin Rattus norvegicus 145-150 41729-3 1979 Concentrations of noradrenaline, adrenaline and methoxamine of 10(-6), 10(-5), 10(-4) and 10(-3) M caused significant dose-related inhibition of renin release. Methoxamine 48-59 renin Rattus norvegicus 145-150 120320-4 1979 Propranolol (1.5 mg/kg) inhibited saralasin-induced renin release by 93% and enhanced the suppressant effect of indomethacin from 79% to 100%. Propranolol 0-11 renin Rattus norvegicus 52-57 120320-5 1979 Meclofenamate, another prostaglandin synthesis inhibitor, also blocked saralasin-induced renin release by 99% and 72% at the 10 and 30 mg/kg doses, respectively (p less than 0.001). Meclofenamic Acid 0-13 renin Rattus norvegicus 89-94 120320-7 1979 In these animals, indomethacin failed to alter basal SRA, but inhibited saralasin-induced renin release by 82%, urinary excretion of PGE2 by 79%, and arachidonate-induced hypotension by 81%. Indomethacin 18-30 renin Rattus norvegicus 90-95 120320-8 1979 These findings suggest 1) that saralasin-induced renin release is mediated by renal prostaglandins, and 2) an interrelationship exists between the receptor controlling AII-mediated inhibition of renin release, which is blocked by saralasin, and the juxtaglomerular beta-adrenergic receptor. Saralasin 31-40 renin Rattus norvegicus 49-54 120320-8 1979 These findings suggest 1) that saralasin-induced renin release is mediated by renal prostaglandins, and 2) an interrelationship exists between the receptor controlling AII-mediated inhibition of renin release, which is blocked by saralasin, and the juxtaglomerular beta-adrenergic receptor. Saralasin 31-40 renin Rattus norvegicus 195-200 120320-8 1979 These findings suggest 1) that saralasin-induced renin release is mediated by renal prostaglandins, and 2) an interrelationship exists between the receptor controlling AII-mediated inhibition of renin release, which is blocked by saralasin, and the juxtaglomerular beta-adrenergic receptor. Prostaglandins 84-98 renin Rattus norvegicus 49-54 232088-8 1979 However, there appears to be an abnormal relationship between renin and exchangeable sodium in the two-kidney hypertensive responders that could contribute to the maintenance of the hypertension. Sodium 85-91 renin Rattus norvegicus 62-67 386137-4 1979 In the present studies, angiotensin II has also been removed from DI rats by the administration of an inhibitor (captopril, SQ 14225; D-2-methyl-3-mercaptopropanoyl-L-proline) of the enzyme which converts angiotensin I, the relatively inert component of the renin-angiotensin system, to angiotensin II, the biologically active substance. Captopril 134-174 renin Rattus norvegicus 258-263 230829-4 1979 The results demonstrate that isolated rat liver perfused with artificial salt solution is capable of synthesizing a protein that reacts with renin to form a radioactive substance indistinguishable from proangiotensin. artificial 62-72 renin Rattus norvegicus 141-146 230829-4 1979 The results demonstrate that isolated rat liver perfused with artificial salt solution is capable of synthesizing a protein that reacts with renin to form a radioactive substance indistinguishable from proangiotensin. salt solution 73-86 renin Rattus norvegicus 141-146 386137-4 1979 In the present studies, angiotensin II has also been removed from DI rats by the administration of an inhibitor (captopril, SQ 14225; D-2-methyl-3-mercaptopropanoyl-L-proline) of the enzyme which converts angiotensin I, the relatively inert component of the renin-angiotensin system, to angiotensin II, the biologically active substance. Captopril 113-122 renin Rattus norvegicus 258-263 225054-1 1979 We studied the effect of alpha-adrenergic stimulation, using phenylephrine, on basal and isoproterenol-provoked renin secretion in the isolated perfused rat kidney. Isoproterenol 89-102 renin Rattus norvegicus 112-117 41720-0 1979 Role of the renin-angiotensin system in the blood pressure rebound to sodium nitroprusside in the conscious rat. Nitroprusside 70-90 renin Rattus norvegicus 12-17 225054-2 1979 Infusion of phenylephrine increased renal perfusion pressure and prevented the response in renin secretion to isoproterenol. Phenylephrine 12-25 renin Rattus norvegicus 91-96 225054-2 1979 Infusion of phenylephrine increased renal perfusion pressure and prevented the response in renin secretion to isoproterenol. Isoproterenol 110-123 renin Rattus norvegicus 91-96 225054-4 1979 Renal vasoconstriction was abolished, and the response in renin secretion to isoproterenol was restored by alpha-adrenoceptor blockade with phenoxybenzamine. Isoproterenol 77-90 renin Rattus norvegicus 58-63 225054-4 1979 Renal vasoconstriction was abolished, and the response in renin secretion to isoproterenol was restored by alpha-adrenoceptor blockade with phenoxybenzamine. Phenoxybenzamine 140-156 renin Rattus norvegicus 58-63 225054-5 1979 In contrast, when renal vasoconstriction was prevented by dihydralazine, suppression of renin release by phenylephrine still occurred. Dihydralazine 58-71 renin Rattus norvegicus 88-93 396287-1 1979 Left renal artery stenosis increased and timolol maleate chronic administration decreased systolic blood pressure, plasma renin activity, and plasma aldosterone concentration, in adult male rats. Timolol 41-56 renin Rattus norvegicus 122-127 225054-5 1979 In contrast, when renal vasoconstriction was prevented by dihydralazine, suppression of renin release by phenylephrine still occurred. Phenylephrine 105-118 renin Rattus norvegicus 88-93 523796-0 1979 Effects of acute hemodialysis-induced changes in sodium balance on the renin-angiotensin system in renovascular and spontaneously hypertensive rats. Sodium 49-55 renin Rattus norvegicus 71-76 522895-0 1979 Studies on the inhibitory effect of indomethacin and meclofenamate on the adrenalectomy-induced increase in plasma renin concentration. Indomethacin 36-48 renin Rattus norvegicus 115-120 522895-0 1979 Studies on the inhibitory effect of indomethacin and meclofenamate on the adrenalectomy-induced increase in plasma renin concentration. Meclofenamic Acid 53-66 renin Rattus norvegicus 115-120 522895-1 1979 Bilateral adrenalectomy combined with a sodium-deficient diet caused a time-dependent increase in plasma renin concentration in rats. Sodium 40-46 renin Rattus norvegicus 105-110 522895-2 1979 Seventy-two hours after adrenalectomy the inhibitors of prostaglandin biosynthesis indomethacin and meclofenamate diminished the plasma renin concentration by about 50%. Prostaglandins 56-69 renin Rattus norvegicus 136-141 522895-2 1979 Seventy-two hours after adrenalectomy the inhibitors of prostaglandin biosynthesis indomethacin and meclofenamate diminished the plasma renin concentration by about 50%. Indomethacin 83-95 renin Rattus norvegicus 136-141 522895-2 1979 Seventy-two hours after adrenalectomy the inhibitors of prostaglandin biosynthesis indomethacin and meclofenamate diminished the plasma renin concentration by about 50%. Meclofenamic Acid 100-113 renin Rattus norvegicus 136-141 522895-4 1979 Indomethacin and meclofenamate fully retained their ability to reduce the plasma renin concentration when the renal sympathetic nerves or the macular densa cells of the kidneys no longer contributed to renin release. Indomethacin 0-12 renin Rattus norvegicus 81-86 398416-2 1979 In the current study, renal renin of rats was increased by chronic sodium deprivation and decreased by chronic sodium loading and DOCA administration. Sodium 67-73 renin Rattus norvegicus 28-33 398416-2 1979 In the current study, renal renin of rats was increased by chronic sodium deprivation and decreased by chronic sodium loading and DOCA administration. Sodium 111-117 renin Rattus norvegicus 28-33 398416-2 1979 In the current study, renal renin of rats was increased by chronic sodium deprivation and decreased by chronic sodium loading and DOCA administration. Desoxycorticosterone Acetate 130-134 renin Rattus norvegicus 28-33 522895-4 1979 Indomethacin and meclofenamate fully retained their ability to reduce the plasma renin concentration when the renal sympathetic nerves or the macular densa cells of the kidneys no longer contributed to renin release. Indomethacin 0-12 renin Rattus norvegicus 202-207 523796-1 1979 In two-kidney Goldblatt hypertensive, spontaneously hypertensive, and normotensive control rats the activity of the renin-angiotensin system was tested during variation of sodium balance. Sodium 172-178 renin Rattus norvegicus 116-121 522895-4 1979 Indomethacin and meclofenamate fully retained their ability to reduce the plasma renin concentration when the renal sympathetic nerves or the macular densa cells of the kidneys no longer contributed to renin release. Meclofenamic Acid 17-30 renin Rattus norvegicus 81-86 522895-4 1979 Indomethacin and meclofenamate fully retained their ability to reduce the plasma renin concentration when the renal sympathetic nerves or the macular densa cells of the kidneys no longer contributed to renin release. Meclofenamic Acid 17-30 renin Rattus norvegicus 202-207 523796-5 1979 During sodium depletion blood pressure maintenance became renin-dependent; sodium loading caused a decrease of renin-angiotensin activity in renovascular hypertension. Sodium 7-13 renin Rattus norvegicus 58-63 522895-5 1979 It is concluded that in adrenalectomized rats renal prostaglandins effect the baro-receptor-mechanism in the afferent arterioles and thus enhance renin release. Prostaglandins 52-66 renin Rattus norvegicus 146-151 523796-5 1979 During sodium depletion blood pressure maintenance became renin-dependent; sodium loading caused a decrease of renin-angiotensin activity in renovascular hypertension. Sodium 75-81 renin Rattus norvegicus 111-116 157270-7 1979 Rats injected with 19-nor-DOCA and given water to drink showed enhanced growth and developed thymus enlargement and displayed hypokalemia and a reduction in both serum renin activity and corticosterone concentration. 19-nor-doca 19-30 renin Rattus norvegicus 168-173 488280-0 1979 The effects of dopamine on renin release in the isolated perfused rat kidney. Dopamine 15-23 renin Rattus norvegicus 27-32 488280-1 1979 In the isolated and perfused kidney of the rat, the stimulant effect of dopamine on renin release is blocked by propranolol and not by haloperidol. Dopamine 72-80 renin Rattus norvegicus 84-89 488280-1 1979 In the isolated and perfused kidney of the rat, the stimulant effect of dopamine on renin release is blocked by propranolol and not by haloperidol. Propranolol 112-123 renin Rattus norvegicus 84-89 488280-2 1979 This suggests that the release of renin induced by dopamine is due to the activation of beta-receptors. Dopamine 51-59 renin Rattus norvegicus 34-39 157270-7 1979 Rats injected with 19-nor-DOCA and given water to drink showed enhanced growth and developed thymus enlargement and displayed hypokalemia and a reduction in both serum renin activity and corticosterone concentration. Water 41-46 renin Rattus norvegicus 168-173 94406-4 1979 However, consistent with the greater selectivity of prazosin for the postsynaptic alpha-receptor, a given reduction in arterial pressure was associated with a lesser increment in heart rate and serum renin activity after prazosin than after the nonselective agent phentolamine. Prazosin 221-229 renin Rattus norvegicus 200-205 504454-0 1979 Water intake and plasma renin activity of rats after intravenous infusions of rat renin. Water 0-5 renin Rattus norvegicus 82-87 508286-4 1979 Renin and acid phosphatase release from the primary-granule preparation was increased by lowering osmolality, by a low-molecular-weight solute (glucose) and by Triton X-100 or digitonin. Glucose 144-151 renin Rattus norvegicus 0-5 508286-4 1979 Renin and acid phosphatase release from the primary-granule preparation was increased by lowering osmolality, by a low-molecular-weight solute (glucose) and by Triton X-100 or digitonin. Octoxynol 160-172 renin Rattus norvegicus 0-5 508286-4 1979 Renin and acid phosphatase release from the primary-granule preparation was increased by lowering osmolality, by a low-molecular-weight solute (glucose) and by Triton X-100 or digitonin. Digitonin 176-185 renin Rattus norvegicus 0-5 477254-10 1979 After oral sodium loading for 3 weeks, rats had suppressed plasma renin activity and kidney renin concentration but unchanged intrarenal ANG II when compared with animals on a normal sodium intake. Sodium 11-17 renin Rattus norvegicus 66-71 508010-7 1979 Thus, propranolol did not decrease blood pressure in most rats with chronic two-kidney Goldblatt hypertension; when it did lower blood pressure, its antihypertensive effect appeared related to its renin suppression effect. Propranolol 6-17 renin Rattus norvegicus 197-202 495153-6 1979 During high sodium intake, the plasma renin activity in subtotally nephrectomized rats was suppressed to one fifth of that in sham-operated animals, but the renin substrate activity did not increase markedly. Sodium 12-18 renin Rattus norvegicus 38-43 477254-8 1979 Animals fed on a sodium-deficient diet for 8 days had markedly higher concentrations of intrarenal ANG II, plasma renin activity and kidney renin concentration than sodium-replete animals. Sodium 17-23 renin Rattus norvegicus 114-119 477254-8 1979 Animals fed on a sodium-deficient diet for 8 days had markedly higher concentrations of intrarenal ANG II, plasma renin activity and kidney renin concentration than sodium-replete animals. Sodium 17-23 renin Rattus norvegicus 140-145 477254-10 1979 After oral sodium loading for 3 weeks, rats had suppressed plasma renin activity and kidney renin concentration but unchanged intrarenal ANG II when compared with animals on a normal sodium intake. Sodium 11-17 renin Rattus norvegicus 92-97 464083-0 1979 Renin and aldosterone secretions during hypovolemia in rats: relation to NaCl intake. Sodium Chloride 73-77 renin Rattus norvegicus 0-5 37256-0 1979 Role of renal prostaglandins in sympathetically mediated renin relase in the rat. Prostaglandins 14-28 renin Rattus norvegicus 57-62 37256-1 1979 Renal prostaglandins (PG) appear to mediate renin release due to stimulation of the intrarenal baroreceptor, but not that due to activation of the macula densa. Prostaglandins 6-20 renin Rattus norvegicus 44-49 37256-1 1979 Renal prostaglandins (PG) appear to mediate renin release due to stimulation of the intrarenal baroreceptor, but not that due to activation of the macula densa. Prostaglandins 22-24 renin Rattus norvegicus 44-49 37256-3 1979 Hydralazine increased the serum renin levels from 3.1+/-0.8 to 16.7+/-3.0 ng/ml per h at a dose of 1 mg/kg. Hydralazine 0-11 renin Rattus norvegicus 32-37 37256-4 1979 Indomethacin (5 mg/kg) suppressed urinary PGE(2) and PGF(2alpha) excretion by 89 and 74%, respectively, arachidonate hypotension by 82%, and inhibited the elevated renin levels from hydralazine by 100% without altering the hypotensive effect of the drug. Indomethacin 0-12 renin Rattus norvegicus 164-169 37256-5 1979 Another PG synthetase inhibitor, meclofenamate, was also effective in attenuating hydralazine-induced renin release, urinary PGE(2) and PGF(2alpha) excretion, and arachidonate hypotension. Meclofenamic Acid 33-46 renin Rattus norvegicus 102-107 37256-5 1979 Another PG synthetase inhibitor, meclofenamate, was also effective in attenuating hydralazine-induced renin release, urinary PGE(2) and PGF(2alpha) excretion, and arachidonate hypotension. Hydralazine 82-93 renin Rattus norvegicus 102-107 37256-6 1979 Isoproterenol, a nonselective beta-adrenergic agonist, increased heart rate, lowered blood pressure, and also stimulated the release of renin when administered intraperitoneally. Isoproterenol 0-13 renin Rattus norvegicus 136-141 37256-8 1979 Indomethacin inhibited isoproterenol-induced renin release by 66 and 67%, respectively, without altering the hemodynamic effects associated with the intraperitoneal administration of the drug. Indomethacin 0-12 renin Rattus norvegicus 45-50 37256-8 1979 Indomethacin inhibited isoproterenol-induced renin release by 66 and 67%, respectively, without altering the hemodynamic effects associated with the intraperitoneal administration of the drug. Isoproterenol 23-36 renin Rattus norvegicus 45-50 37256-10 1979 H133/22-induced renin release was inhibited by 80% by indomethacin pretreatment. Indomethacin 54-66 renin Rattus norvegicus 16-21 37256-12 1979 Indomethacin inhibited this renin response to dibutyryl cyclic AMP by 96%. Indomethacin 0-12 renin Rattus norvegicus 28-33 37256-12 1979 Indomethacin inhibited this renin response to dibutyryl cyclic AMP by 96%. Bucladesine 46-66 renin Rattus norvegicus 28-33 159697-1 1979 A NaCl load in chronically hypoxic rats abolished the increase in plasma renin activity occurring in rats exposed to hypoxia of the same degree and duration but with normal NaCl intake. Sodium Chloride 2-6 renin Rattus norvegicus 73-78 159697-2 1979 The parallel reduction in hypoxic hypertrophy of the right ventricle in NaCl-loaded rats could be considered as indirect evidence supporting the view that renin may be involved in the development of heart hypertrophy. Sodium Chloride 72-76 renin Rattus norvegicus 155-160 464083-1 1979 Plasma renin activities (PRA) and aldosterone concentrations increased in parallel over a wide range of plasma volume deficits produced in unanesthetized rats by extravascular administration of polyethylene glycol (PEG) solution. Polyethylene Glycols 194-213 renin Rattus norvegicus 7-12 464083-1 1979 Plasma renin activities (PRA) and aldosterone concentrations increased in parallel over a wide range of plasma volume deficits produced in unanesthetized rats by extravascular administration of polyethylene glycol (PEG) solution. Polyethylene Glycols 215-218 renin Rattus norvegicus 7-12 479736-2 1979 The diuretic drug frusemide brought about a rapid increase in plasma renin activity and aldosterone concentration in serum. Furosemide 18-27 renin Rattus norvegicus 69-74 231700-5 1979 Plasma renin activity increased approximately 2-3 fold after hydralazine and 15-fold after captopril. Hydralazine 61-72 renin Rattus norvegicus 7-12 490364-0 1979 Influence of potassium, sodium, perfusion pressure, and isoprenaline on renin release induced by acute calcium deprivation. Potassium 13-22 renin Rattus norvegicus 72-77 490364-0 1979 Influence of potassium, sodium, perfusion pressure, and isoprenaline on renin release induced by acute calcium deprivation. Isoproterenol 56-68 renin Rattus norvegicus 72-77 490364-0 1979 Influence of potassium, sodium, perfusion pressure, and isoprenaline on renin release induced by acute calcium deprivation. Calcium 103-110 renin Rattus norvegicus 72-77 490364-4 1979 Lowering concentration of Ca in the perfusion medium from 5 to 0 mM increased the effectiveness of low perfusion pressure (50 mmHg) and isoprenaline (2.43 muM) in stimulating renin release.4. Isoproterenol 136-148 renin Rattus norvegicus 175-180 490364-8 1979 Adding 5 mM-EGTA to Ca-deprived medium stimulated a greater rate of renin release than that of Ca-deprived medium alone. Egtazic Acid 12-16 renin Rattus norvegicus 68-73 490364-10 1979 Lowering concentration of Na in the perfusion medium from 145 to 25 mM partially inhibited the renin release induced by Ca deprivation in the presence of low perfusion pressure or isoprenaline.7. Isoproterenol 180-192 renin Rattus norvegicus 95-100 490366-0 1979 Influence of potassium, sodium, calcium, perfusion pressure, and isoprenaline on renin release induced by high concentrations of magnesium. Isoproterenol 65-77 renin Rattus norvegicus 81-86 490366-0 1979 Influence of potassium, sodium, calcium, perfusion pressure, and isoprenaline on renin release induced by high concentrations of magnesium. Magnesium 129-138 renin Rattus norvegicus 81-86 490366-2 1979 These studies were conducted on isolated, perfused rat kidneys to determine the mechanism through which high concentrations of extracellular Mg (20mM) stimulated renin release. Magnesium 141-143 renin Rattus norvegicus 162-167 490366-7 1979 Renin release induced by low renal perfusion pressure (50 mmHg) or isoprenaline (2.43 microM) was unaffected by 20 mM-Mg. Isoproterenol 67-79 renin Rattus norvegicus 0-5 490366-9 1979 In medium containing 20 mM-Mg, lowering Na concentration from 145 to 100 mM augmented the renin release induced by low perfusion pressure and isoprenaline. Isoproterenol 142-154 renin Rattus norvegicus 90-95 428074-0 1979 Stimulation of renin by acute selective chloride depletion in the rat. Chlorides 40-48 renin Rattus norvegicus 15-20 428074-16 1979 We conclude that acute selective chloride depletion per se is a potent stimulus for renin release. Chlorides 33-41 renin Rattus norvegicus 84-89 480253-0 1979 The role of circulating renin in drinking in response to isoprenaline. Isoproterenol 57-69 renin Rattus norvegicus 24-29 480253-14 1979 Since isoprenaline induces drinking in the presence of circulating renin, but in the absence of renin release from kidneys, renin plays a permissive role in isoprenaline-induced drinking. Isoproterenol 6-18 renin Rattus norvegicus 67-72 484065-2 1979 By chronic load with sodium chloride was tried to produce a decrease of renin. Sodium Chloride 21-36 renin Rattus norvegicus 72-77 399928-2 1979 The results show the two-phase behaviour of PRA (plasma renin activity), which is related to aldosterone levels. Aldosterone 93-104 renin Rattus norvegicus 56-61 223856-7 1979 Since isoprenaline-induced and angiotensin I-induced, but not angiotensin II-induced, thirsts are blocked by SQ 14,225, the results suggest that isoprenaline-induced thirst is mediated by way of the renin--angiotensin system. Isoproterenol 145-157 renin Rattus norvegicus 199-204 443387-8 1979 These data are interpreted to mean that the renin released into the incubation medium is inactivated at the air-water interface. Water 112-117 renin Rattus norvegicus 44-49 443388-5 1979 Plasma renin activity although decreased in the hypertensive saline-treated animals was not suppressed. Sodium Chloride 61-67 renin Rattus norvegicus 7-12 231700-5 1979 Plasma renin activity increased approximately 2-3 fold after hydralazine and 15-fold after captopril. Captopril 91-100 renin Rattus norvegicus 7-12 231700-7 1979 These results indicate that chronic inhibition of ACE with captopril induces normalization of blood pressure in SHR, a normal-renin model of hypertension. Captopril 59-68 renin Rattus norvegicus 126-131 436936-4 1979 Chronic saline loading reduced the plasma renin concentration (PRC) and the heart noradrenaline concentration and elevated the plasma cholesterol. Sodium Chloride 8-14 renin Rattus norvegicus 42-47 760897-0 1979 A comparative study of the action of frusemide and methyclothiazide on renin release by rat kidney slices and the interaction with indomethacin. Furosemide 37-46 renin Rattus norvegicus 71-76 426075-2 1979 Along with salt-loading, blood pressure gradually increased and reached a severe hypertensive level (greater than 230 mmHg), which was followed by increases in urinary protein (greater than 100 (mg/250 g body wt)/day) and plasma renin concentration (PRC, from 18.9 +/- 0.1 to 51.2 +/- 19.4 (ng/ml)/h, mean +/- SD). Salts 11-15 renin Rattus norvegicus 229-234 426075-7 1979 These findings suggest that the activation of renin-angiotensin system participates in malignant hypertension of salt-loaded stroke-prone SHR rats that show stroke signs, proteinuria, hyperreninemia, and renovascular changes. Salts 113-117 renin Rattus norvegicus 46-51 286300-8 1979 These prostaglandins may exert important physiologic effects, because renin secretion and arteriolar resistance are regulated by the glomerulus and the afferent and efferent arterioles. Prostaglandins 6-20 renin Rattus norvegicus 70-75 420931-5 1979 The following occurred in 8 to 12 weeks with the restoration of the 11-OCS and sodium level in the plasma: renin JGC activity became normal, RLA activity in MC disappeared, and the initial ultrastructure of both of these cells was restored. Sodium 79-85 renin Rattus norvegicus 107-112 432446-0 1979 [Effect of urethane and penthobarbital on the behaviour of the renin-angiotensin-system in rat (author"s transl)]. Urethane 11-19 renin Rattus norvegicus 63-68 432446-0 1979 [Effect of urethane and penthobarbital on the behaviour of the renin-angiotensin-system in rat (author"s transl)]. penthobarbital 24-38 renin Rattus norvegicus 63-68 432446-1 1979 The behaviour of the renin-angiotensin-system was investigated after urethane and penthobarbital anaesthesia in rats. Urethane 69-77 renin Rattus norvegicus 21-26 432446-1 1979 The behaviour of the renin-angiotensin-system was investigated after urethane and penthobarbital anaesthesia in rats. penthobarbital 82-96 renin Rattus norvegicus 21-26 432446-2 1979 The recent results support the early observation that urethane increases the plasma-renin-activity and the haematocrit. Urethane 54-62 renin Rattus norvegicus 84-89 432446-3 1979 It was further shown that urethane in the customary anaesthetic dose causes hypoproteinaemia and a decrease in the pressor response to angiotensin and in renin substrate concentration. Urethane 26-34 renin Rattus norvegicus 154-159 232670-6 1979 The recently proposed role of ATI as mediator of renin in the adrenal medulla is not substantiated by pharmacological findings with decapeptide antagonists. 4-Amino-2,2,5,5-tetramethyl-3-imidazoli-ne-1-yloxyl free radical 30-33 renin Rattus norvegicus 49-54 760897-0 1979 A comparative study of the action of frusemide and methyclothiazide on renin release by rat kidney slices and the interaction with indomethacin. Methyclothiazide 51-67 renin Rattus norvegicus 71-76 760897-1 1979 1 The effects of frusemide (a diuretic acting on the loop of Henle) and methyclothiazide (a thiazide diuretic) on renin release were studied on rat kidney slices. Methyclothiazide 72-88 renin Rattus norvegicus 114-119 760897-1 1979 1 The effects of frusemide (a diuretic acting on the loop of Henle) and methyclothiazide (a thiazide diuretic) on renin release were studied on rat kidney slices. Thiazides 80-88 renin Rattus norvegicus 114-119 760897-2 1979 2 Frusemide at concentrations of 1.5 and 7.5 mmol/l produced significant increases in renin release but had no effect at 0.15 mmol/l. Furosemide 2-11 renin Rattus norvegicus 86-91 421968-0 1979 Renin-angiotensin system in phlorhizin compared with alloxan diabetes in the rat. Phlorhizin 28-38 renin Rattus norvegicus 0-5 760897-3 1979 3 Methyclothiazide in a similar concentration range did not increase renin release; instead, at the highest concentration used, methyclothiazide (3.5 mmol/l) inhibited renin release. Methyclothiazide 128-144 renin Rattus norvegicus 168-173 421968-2 1979 One possible mechanism that may explain the decreased PRA is an increased delivery of sodium to the macula densa produced by the glucose osmotic diuresis, resulting in decreased renin release. Sodium 86-92 renin Rattus norvegicus 178-183 439781-1 1979 After a single oral dose of 4 mg/kg indomethacin (IDM) to sodium and volume depleted rats plasma renin activity (PRA) and systolic blood pressure fell significantly within four hours. Indomethacin 36-48 renin Rattus norvegicus 97-102 421968-2 1979 One possible mechanism that may explain the decreased PRA is an increased delivery of sodium to the macula densa produced by the glucose osmotic diuresis, resulting in decreased renin release. Glucose 129-136 renin Rattus norvegicus 178-183 421968-5 1979 PRA and plasma renin concentration (PRC) were significantly increased in the phlorhizin group. Phlorhizin 77-87 renin Rattus norvegicus 15-20 439781-2 1979 In sodium repleted animals indomethacin did not change systolic blood pressure (BP) although plasma renin activity was decreased. Sodium 3-9 renin Rattus norvegicus 100-105 762665-5 1979 Peripheral renin activity first increased 7 days after LRA but decreased 28 days after LRA despite persistent hypertension in controls and alpha-methyldopa-treated rats. Methyldopa 139-155 renin Rattus norvegicus 11-16 439781-3 1979 Thus, indomethacin by inhibition of prostaglandin synthesis may diminish the blood pressure maintaining effect of the stimulated renin-angiotensin system in sodium and volume depletion. Indomethacin 6-18 renin Rattus norvegicus 129-134 439781-3 1979 Thus, indomethacin by inhibition of prostaglandin synthesis may diminish the blood pressure maintaining effect of the stimulated renin-angiotensin system in sodium and volume depletion. Prostaglandins 36-49 renin Rattus norvegicus 129-134 396760-4 1979 Pindolol, on the other hand, in a concentration of 3 X 10(-5) M caused a significant decrease in the renin release from as well as in the renin content of the rat kidney slices, while canine kidney slices failed to respond to the same dose of the drug. Pindolol 0-8 renin Rattus norvegicus 101-106 760354-0 1979 Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats. Spironolactone 10-24 renin Rattus norvegicus 66-71 760354-0 1979 Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats. Canrenone 49-58 renin Rattus norvegicus 66-71 396760-4 1979 Pindolol, on the other hand, in a concentration of 3 X 10(-5) M caused a significant decrease in the renin release from as well as in the renin content of the rat kidney slices, while canine kidney slices failed to respond to the same dose of the drug. Pindolol 0-8 renin Rattus norvegicus 138-143 396761-0 1979 Changes of plasma renin and renal renin concentration in HgCl2 induced acute renal failure in rats. Mercuric Chloride 57-62 renin Rattus norvegicus 18-23 396761-0 1979 Changes of plasma renin and renal renin concentration in HgCl2 induced acute renal failure in rats. Mercuric Chloride 57-62 renin Rattus norvegicus 34-39 495127-0 1979 Alleviating effect of pindolol in HgCL2-induced acute renal failure in rats: effect of HgCl2 and pindolol on renin release in vitro. Pindolol 97-105 renin Rattus norvegicus 109-114 219704-0 1979 Effect of tolbutamide on plasma renin activity. Tolbutamide 10-21 renin Rattus norvegicus 32-37 390990-4 1979 Plasma renin and blood angiotensin I were closely linearly related over the range of sodium intakes. Sodium 85-91 renin Rattus norvegicus 7-12 219704-1 1979 The effect of tolbutamide on renin secretion in rats was studied in vivo, and in vitro. Tolbutamide 14-25 renin Rattus norvegicus 29-34 734651-1 1978 Administration of 1.5 mg/kg of estriol intramuscularly and 15 mg/kg of stilbestrol disulfate intraperitoneally daily for 15 days caused an increase in plasma renin substrate (PRS), accompanied by an increase in plasma renin activity (PRA) and a slight decrease in plasma renin concentration (PRC). Estriol 31-38 renin Rattus norvegicus 158-163 397195-8 1979 The present study demonstrates that partial inhibition of the renin-angiotensin system with captopril results in a delay in the natural evolution of clip hypertension retarding the appearance of hypertension that is resistant to acute saralasin infusion. Captopril 92-101 renin Rattus norvegicus 62-67 523507-4 1979 While attenuation of the drinking response to isoproterenol in DOC-treated rats may be attributed to depletion of renin from their kidneys, the mechanisms responsible for the enhanced drinking response to angiotensin II are not clearly understood. Isoproterenol 46-59 renin Rattus norvegicus 114-119 523507-4 1979 While attenuation of the drinking response to isoproterenol in DOC-treated rats may be attributed to depletion of renin from their kidneys, the mechanisms responsible for the enhanced drinking response to angiotensin II are not clearly understood. Desoxycorticosterone 63-66 renin Rattus norvegicus 114-119 282046-6 1978 This compound inhibited in vitro the reaction between purified hog renin and the synthetic renin N-acetyl-tetradecapeptide or the natural rat renin substrate. n-acetyl-tetradecapeptide 97-122 renin Rattus norvegicus 67-72 282046-6 1978 This compound inhibited in vitro the reaction between purified hog renin and the synthetic renin N-acetyl-tetradecapeptide or the natural rat renin substrate. n-acetyl-tetradecapeptide 97-122 renin Rattus norvegicus 91-96 282046-6 1978 This compound inhibited in vitro the reaction between purified hog renin and the synthetic renin N-acetyl-tetradecapeptide or the natural rat renin substrate. n-acetyl-tetradecapeptide 97-122 renin Rattus norvegicus 91-96 282058-4 1978 Rat aortic renin measured at an incubation pH of 6.5 rose and fell in parallel to plasma renin with salt depletion and salt-loading respectively. Salts 100-104 renin Rattus norvegicus 89-94 282058-4 1978 Rat aortic renin measured at an incubation pH of 6.5 rose and fell in parallel to plasma renin with salt depletion and salt-loading respectively. Salts 119-123 renin Rattus norvegicus 11-16 710591-2 1978 First, although administration of exogenous renin consistently increases water intake, the plasma renin activities that are produced seem to be outside of the normal physiological range when the elicited drinking is substantial. Water 73-78 renin Rattus norvegicus 44-49 710591-3 1978 Second, although plasma renin activities are elevated following caval ligation, colloid, or isoproterenol treatment, this activity of the renin-angiotensin system appears to account for only a small portion of the observed water intake. Isoproterenol 92-105 renin Rattus norvegicus 24-29 710591-3 1978 Second, although plasma renin activities are elevated following caval ligation, colloid, or isoproterenol treatment, this activity of the renin-angiotensin system appears to account for only a small portion of the observed water intake. Water 223-228 renin Rattus norvegicus 138-143 441427-1 1979 Prostaglandins are thought to play an important role in the local regulation of glomerular blood flow and in the release of renin from the juxtaglomerular apparatus. Prostaglandins 0-14 renin Rattus norvegicus 124-129 747726-0 1978 Effect of high dose d-l propranolol on the renin-angiotensin system in glycerol induced acute renal failure in rat. d-l propranolol 20-35 renin Rattus norvegicus 43-48 747726-0 1978 Effect of high dose d-l propranolol on the renin-angiotensin system in glycerol induced acute renal failure in rat. Glycerol 71-79 renin Rattus norvegicus 43-48 747726-3 1978 50% glycerol administered alone, induced a significant rise in blood urea and plasma renin concentration but no significant change in renal renin concentration. Glycerol 4-12 renin Rattus norvegicus 85-90 747726-4 1978 When administered with d-l propranolol (10 mg/kg body weight in 5 subcutaneous injections), mean blood urea, plasma renin and renal renin concentrations were not significantly different from the preceding group. d-l propranolol 23-38 renin Rattus norvegicus 116-121 747726-4 1978 When administered with d-l propranolol (10 mg/kg body weight in 5 subcutaneous injections), mean blood urea, plasma renin and renal renin concentrations were not significantly different from the preceding group. d-l propranolol 23-38 renin Rattus norvegicus 132-137 747726-5 1978 Propranolol alone, administered in the same fashion, unexpectedly induced a rise in plasma renin concentration (p less than 0.05) while blood urea and renal renin concentrations were unchanged. Propranolol 0-11 renin Rattus norvegicus 91-96 747726-7 1978 Plasma renin concentration rose after high dose propranolol, but decreased, although not significantly, after administration of 1 mg/kg. Propranolol 48-59 renin Rattus norvegicus 7-12 31796-0 1978 Importance of chloride for acute inhibition of renin by sodium chloride. Chlorides 14-22 renin Rattus norvegicus 47-52 31796-0 1978 Importance of chloride for acute inhibition of renin by sodium chloride. Sodium Chloride 56-71 renin Rattus norvegicus 47-52 31796-5 1978 These results suggest that inhibition of renin by sodium is dependent on an intrarenal effect of chloride. Sodium 50-56 renin Rattus norvegicus 41-46 31796-5 1978 These results suggest that inhibition of renin by sodium is dependent on an intrarenal effect of chloride. Chlorides 97-105 renin Rattus norvegicus 41-46 31796-6 1978 During infusion with sodium salts which suppressed renin, negative free water clearance (TcH2O) increased, whereas infusion with sodium salts that did not inhibit renin resulted in either no change or decreased TcH2O. sodium salts 21-33 renin Rattus norvegicus 51-56 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. tch2o 50-55 renin Rattus norvegicus 19-24 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. tch2o 50-55 renin Rattus norvegicus 96-101 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. Chlorides 117-125 renin Rattus norvegicus 19-24 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. Chlorides 117-125 renin Rattus norvegicus 96-101 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. Chlorides 168-176 renin Rattus norvegicus 19-24 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. Chlorides 168-176 renin Rattus norvegicus 96-101 364507-0 1978 Antihypertensive effect of prostacyclin (PGI2) in experimental hypertension and its influence on plasma renin activity in rats. Epoprostenol 27-39 renin Rattus norvegicus 104-109 364507-5 1978 PGI2 induced an increase of plasma renin activity in anaesthetized rats with doses of 0.1, 1.0 and 10.0 micrograms/kg. Epoprostenol 0-4 renin Rattus norvegicus 35-40 213296-8 1978 In four other similarly treated groups of RHR and normotensive rats (NR), least cardiac hypertrophy and highest plasma renin activity occurred in captopril-treated animals compared with vehicle-treated controls. Captopril 146-155 renin Rattus norvegicus 119-124 213296-9 1978 Plasma renin activity was about 2 to 4 fold higher in the rats dosed with captopril compared with vehicle-treated rats. Captopril 74-83 renin Rattus norvegicus 7-12 718949-4 1978 The amino acid composition is also closely analogous to hog renin, except that rat renin has a higher cysteine content. Cysteine 102-110 renin Rattus norvegicus 83-88 734651-1 1978 Administration of 1.5 mg/kg of estriol intramuscularly and 15 mg/kg of stilbestrol disulfate intraperitoneally daily for 15 days caused an increase in plasma renin substrate (PRS), accompanied by an increase in plasma renin activity (PRA) and a slight decrease in plasma renin concentration (PRC). Estriol 31-38 renin Rattus norvegicus 218-223 734651-1 1978 Administration of 1.5 mg/kg of estriol intramuscularly and 15 mg/kg of stilbestrol disulfate intraperitoneally daily for 15 days caused an increase in plasma renin substrate (PRS), accompanied by an increase in plasma renin activity (PRA) and a slight decrease in plasma renin concentration (PRC). Estriol 31-38 renin Rattus norvegicus 218-223 734651-1 1978 Administration of 1.5 mg/kg of estriol intramuscularly and 15 mg/kg of stilbestrol disulfate intraperitoneally daily for 15 days caused an increase in plasma renin substrate (PRS), accompanied by an increase in plasma renin activity (PRA) and a slight decrease in plasma renin concentration (PRC). Diethylstilbestrol disulfate 71-92 renin Rattus norvegicus 158-163 734651-1 1978 Administration of 1.5 mg/kg of estriol intramuscularly and 15 mg/kg of stilbestrol disulfate intraperitoneally daily for 15 days caused an increase in plasma renin substrate (PRS), accompanied by an increase in plasma renin activity (PRA) and a slight decrease in plasma renin concentration (PRC). Diethylstilbestrol disulfate 71-92 renin Rattus norvegicus 218-223 734651-1 1978 Administration of 1.5 mg/kg of estriol intramuscularly and 15 mg/kg of stilbestrol disulfate intraperitoneally daily for 15 days caused an increase in plasma renin substrate (PRS), accompanied by an increase in plasma renin activity (PRA) and a slight decrease in plasma renin concentration (PRC). Diethylstilbestrol disulfate 71-92 renin Rattus norvegicus 218-223 210883-3 1978 Prior intracranial injection of pepstatin, a competitive antagonist of the renin-angiotensinogen reaction, reduced drinking in response to renin and SRS but not to AI and AII. pepstatin 32-41 renin Rattus norvegicus 75-80 723008-0 1978 Effects of 3-amino,1,2,4-triazole on plasma renin activity and renal peroxisomal enzymes in rats. Amitrole 11-33 renin Rattus norvegicus 44-49 210883-3 1978 Prior intracranial injection of pepstatin, a competitive antagonist of the renin-angiotensinogen reaction, reduced drinking in response to renin and SRS but not to AI and AII. pepstatin 32-41 renin Rattus norvegicus 139-144 210883-5 1978 Finally, position 8 aliphatic substituted analogues of AII were competitive antagonists of AII-induced drinking, and also inhibited drinking induced by renin, SRS and AI injected through the same intracranial cannula, but they did not inhibit carbachol-induced drinking. aliphatic 20-29 renin Rattus norvegicus 152-157 722522-4 1978 Raising perfusate K concentration from 4.2 to 56 mM suppressed basal renin release, and the 56 mM-K inhibited the renin release induced by low perfusion pressure (50 mmHg) or phenylephrine (0.83 micrometers). Phenylephrine 175-188 renin Rattus norvegicus 114-119 699500-15 1978 These results suggest that the increase in renal vascular resistance and the stimulation of renin release after injection of glycerol in vivo are the consequence of extra- rather than intra-renal mechanisms. Glycerol 125-133 renin Rattus norvegicus 92-97 699502-2 1978 A renin-like enzyme in aortic tissue of the spontaneously hypertensive rat was found to be a freely dissociable enzyme (saline homogenization) with an affinity for the renin inhibitor pepstatin. Sodium Chloride 120-126 renin Rattus norvegicus 2-7 699502-2 1978 A renin-like enzyme in aortic tissue of the spontaneously hypertensive rat was found to be a freely dissociable enzyme (saline homogenization) with an affinity for the renin inhibitor pepstatin. Sodium Chloride 120-126 renin Rattus norvegicus 168-173 699502-2 1978 A renin-like enzyme in aortic tissue of the spontaneously hypertensive rat was found to be a freely dissociable enzyme (saline homogenization) with an affinity for the renin inhibitor pepstatin. pepstatin 184-193 renin Rattus norvegicus 2-7 699502-2 1978 A renin-like enzyme in aortic tissue of the spontaneously hypertensive rat was found to be a freely dissociable enzyme (saline homogenization) with an affinity for the renin inhibitor pepstatin. pepstatin 184-193 renin Rattus norvegicus 168-173 699502-8 1978 Plasma renin concentration and the aortic renin content of the spontaneously hypertensive rat showed divergent changes in response to a blood pressure fall associated with acute diuretic therapy, chronic administration of hydrallazine and in some animals in response to chronic administration of propranolol. Hydralazine 222-234 renin Rattus norvegicus 7-12 699502-8 1978 Plasma renin concentration and the aortic renin content of the spontaneously hypertensive rat showed divergent changes in response to a blood pressure fall associated with acute diuretic therapy, chronic administration of hydrallazine and in some animals in response to chronic administration of propranolol. Hydralazine 222-234 renin Rattus norvegicus 42-47 699502-10 1978 A low sodium diet elevated both plasma and aortic renin and retarded the progressive increase of blood pressure in the spontaneously hypertensive rat. Sodium 6-12 renin Rattus norvegicus 50-55 722522-6 1978 Isoprenaline (0.79 micrometers) induced a marked increase in renin release; but high perfusate K, propranolol (0.28 mM), papaverine (0.39 mM), or high perfusion pressure (150 mmHg) inhibited this effect. Isoproterenol 0-12 renin Rattus norvegicus 61-66 722522-8 1978 It is concluded that high perfusate K has a powerful inhibitory effect on the renin release induced by renal hypotension, vasoconstriction, and isoprenaline infusion, and that this effect may be mimicked by high perfusion pressure or renal vasodilation. Isoproterenol 144-156 renin Rattus norvegicus 78-83 211515-0 1978 Regulation of aldosterone secretion by the renin-angiotensin system during sodium restriction in rats. Sodium 75-81 renin Rattus norvegicus 43-48 675249-3 1978 Lithium increased the plasma renin activity equally in both the lead treated and the control groups. Lithium 0-7 renin Rattus norvegicus 29-34 213037-1 1978 The beta-adrenoceptor antagonists, atenolol, metoprolol and propranolol, administered intravenously to anaesthetized rats in doses producing equal beta1-adrenoceptor blocking effects, caused comparable suppression of plasma renin activity (PRA) despite the fact that, at these doses, atenolol and metoprolol exhibited no beta2-adrenoceptor blocking properties. Propranolol 60-71 renin Rattus norvegicus 224-229 28415-8 1978 Only plasma renin activity showed a significantly greater elevation during withdrawal of the high dose of clonidine. Clonidine 106-115 renin Rattus norvegicus 12-17 211515-4 1978 The absolute dependence of adrenal glomerulosa cell responses on angiotensin II formation indicates that the renin-angiotensin system is the primary regulator of aldosterone secretion during physiological fluctuations in sodium intake. Sodium 221-227 renin Rattus norvegicus 109-114 27279-0 1978 Evidence for the participation of beta1-adrenoceptors in isoprenaline-induced renin release from rat kidny slices in vitro. Isoproterenol 57-69 renin Rattus norvegicus 78-83 27279-2 1978 The inhibitory effects were studied of 4 beta-adrenoceptor antagonists against renin release induced by isoprenaline (0.5 mumol/1) in rat kidney slices. Isoproterenol 104-116 renin Rattus norvegicus 79-84 673021-0 1978 Inhibitory effect of tyramine-induced release of catecholamines on renin secretion. Tyramine 21-29 renin Rattus norvegicus 67-72 666023-9 1978 The authors conclude that the anesthetic agents studied increase renin release in the sodium-depleted rat. Sodium 86-92 renin Rattus norvegicus 65-70 673021-0 1978 Inhibitory effect of tyramine-induced release of catecholamines on renin secretion. Catecholamines 49-63 renin Rattus norvegicus 67-72 673021-1 1978 The effect of the indirect sympathomimetic agent tyramine on the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats. Tyramine 49-57 renin Rattus norvegicus 105-110 673021-1 1978 The effect of the indirect sympathomimetic agent tyramine on the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats. Isoproterenol 65-77 renin Rattus norvegicus 105-110 673021-2 1978 Tyramine caused a dose-dependent decrease in the isoprenaline-induced elevation of plasma renin concentration. Tyramine 0-8 renin Rattus norvegicus 90-95 673021-2 1978 Tyramine caused a dose-dependent decrease in the isoprenaline-induced elevation of plasma renin concentration. Isoproterenol 49-61 renin Rattus norvegicus 90-95 658246-0 1978 Influence of age on the renal renin response to a high salt intake in the rat. Salts 55-59 renin Rattus norvegicus 30-35 673021-4 1978 Pretreatment with phenoxybenzamine, an alpha-adrenoceptor antagonist, also abolished the inhibitory effect of tyramine on renin release, indicating that alpha-adrenoceptors mediated the observed inhibition of renin release. Phenoxybenzamine 18-34 renin Rattus norvegicus 122-127 658246-1 1978 Saline drinking combined with DOCA-treatment was found to decrease renal renin in weanlings at a higher rate than in adult rats, with a comparable saline consumption level. Sodium Chloride 0-6 renin Rattus norvegicus 73-78 673021-4 1978 Pretreatment with phenoxybenzamine, an alpha-adrenoceptor antagonist, also abolished the inhibitory effect of tyramine on renin release, indicating that alpha-adrenoceptors mediated the observed inhibition of renin release. Phenoxybenzamine 18-34 renin Rattus norvegicus 209-214 658246-1 1978 Saline drinking combined with DOCA-treatment was found to decrease renal renin in weanlings at a higher rate than in adult rats, with a comparable saline consumption level. Desoxycorticosterone Acetate 30-34 renin Rattus norvegicus 73-78 673021-4 1978 Pretreatment with phenoxybenzamine, an alpha-adrenoceptor antagonist, also abolished the inhibitory effect of tyramine on renin release, indicating that alpha-adrenoceptors mediated the observed inhibition of renin release. Tyramine 110-118 renin Rattus norvegicus 122-127 673021-4 1978 Pretreatment with phenoxybenzamine, an alpha-adrenoceptor antagonist, also abolished the inhibitory effect of tyramine on renin release, indicating that alpha-adrenoceptors mediated the observed inhibition of renin release. Tyramine 110-118 renin Rattus norvegicus 209-214 673021-6 1978 It is concluded that catecholamines which are released from renal sympathetic nerve endings can suppress renin release by activating alpha-adrenoceptors. Catecholamines 21-35 renin Rattus norvegicus 105-110 673017-0 1978 Renal action of adenosine: effect on renin secretion in the rat. Adenosine 16-25 renin Rattus norvegicus 37-42 686910-10 1978 Diazoxide significantly increased plasma FFA and plasma renin activity but Go.8288 had no effect. Diazoxide 0-9 renin Rattus norvegicus 56-61 648588-0 1978 Mechanism of inhibition of renin release by clonidine in rats. Clonidine 44-53 renin Rattus norvegicus 27-32 648588-1 1978 In anaesthetized rats, the intracisternal injection of clonidine (1 microgram/kg) reduced mean arterial pressure (MAP), increased plasma renin concentration (PRC) while naphazoline (5 microgram/kg) was ineffective. Clonidine 55-64 renin Rattus norvegicus 137-142 648588-6 1978 clonidine and naphazoline reduce renin release through activation of alpha-adrenoceptors within the kidney. Clonidine 0-9 renin Rattus norvegicus 33-38 648588-6 1978 clonidine and naphazoline reduce renin release through activation of alpha-adrenoceptors within the kidney. Naphazoline 14-25 renin Rattus norvegicus 33-38 640802-2 1978 Support of this hypothesis was forwarded by the finding that propranolol, a blocker of renin release, reduced the deleterious effect of ischemia on kidney function. Propranolol 61-72 renin Rattus norvegicus 87-92 624144-0 1978 Isoproterenol-evoked renin release from the in situ perfused kidney. Isoproterenol 0-13 renin Rattus norvegicus 21-26 207081-5 1978 Arterial blood pressure rise after intraventricular administration of noradrenaline is caused by activation of the renin-angiotensin system in the periphery. Norepinephrine 70-83 renin Rattus norvegicus 115-120 623774-3 1978 Renin was purified 30 000-fold from rat kidneys by chromatography on DEAE-cellulose and SP-Sephadex, and by affinity chromatography on pepstatinyl-Sepharose. DEAE-Cellulose 69-83 renin Rattus norvegicus 0-5 651121-0 1978 Contribution of chloride to the inhibition of plasma renin by sodium chloride in the rat. Chlorides 16-24 renin Rattus norvegicus 53-58 651121-0 1978 Contribution of chloride to the inhibition of plasma renin by sodium chloride in the rat. Sodium Chloride 62-77 renin Rattus norvegicus 53-58 631188-4 1978 Comparison of changes in these parameters in atenolol-treated SHRs, control SHRs and WKYs strongly suggests that the mechanism of atenolol"s preventive action against hypertension development in SHRs primarily involves its effects on heart and on the renin--angiotensin system. Atenolol 45-53 renin Rattus norvegicus 251-256 631188-4 1978 Comparison of changes in these parameters in atenolol-treated SHRs, control SHRs and WKYs strongly suggests that the mechanism of atenolol"s preventive action against hypertension development in SHRs primarily involves its effects on heart and on the renin--angiotensin system. Atenolol 130-138 renin Rattus norvegicus 251-256 623774-3 1978 Renin was purified 30 000-fold from rat kidneys by chromatography on DEAE-cellulose and SP-Sephadex, and by affinity chromatography on pepstatinyl-Sepharose. sp-sephadex 88-99 renin Rattus norvegicus 0-5 623774-3 1978 Renin was purified 30 000-fold from rat kidneys by chromatography on DEAE-cellulose and SP-Sephadex, and by affinity chromatography on pepstatinyl-Sepharose. pepstatinyl-sepharose 135-156 renin Rattus norvegicus 0-5 565030-4 1978 Iso-renin output almost doubled upon raising NaCl from 120 to 240 mM. Sodium Chloride 45-49 renin Rattus norvegicus 4-9 202693-1 1978 SQ 14,225 (D-3-mercapto-2-methylpropanoyl-L-proline) markedly lowered the blood pressure of the renin-dependent aortic-ligated and two-kidney Goldblatt hypertensive rat and failed to reduce blood pressure in the one-kidney Goldblatt hypertensive rat. Captopril 11-51 renin Rattus norvegicus 96-101 23297-2 1978 Intravenous infusions of isoprenaline, salbutamol and carbuterol did not affect insulin clearance but increased plasma renin concentration to the same same extent. Isoproterenol 25-37 renin Rattus norvegicus 119-124 23297-2 1978 Intravenous infusions of isoprenaline, salbutamol and carbuterol did not affect insulin clearance but increased plasma renin concentration to the same same extent. Albuterol 39-49 renin Rattus norvegicus 119-124 565030-5 1978 Decrease of the NaCl concentration to 60 mM resulted in a reduced iso renin secretion while addition of tetrodotoxin (TTX) (60 micron) did not significantly alter the iso-renin content of brain slices. Sodium Chloride 16-20 renin Rattus norvegicus 70-75 23297-2 1978 Intravenous infusions of isoprenaline, salbutamol and carbuterol did not affect insulin clearance but increased plasma renin concentration to the same same extent. carbuterol 54-64 renin Rattus norvegicus 119-124 636807-4 1978 During 3% anaesthesia, plasma renin activity was markedly increased in the methyldopa group and decreased in the propranolol group. Methyldopa 75-85 renin Rattus norvegicus 30-35 742304-6 1978 The renin activities in the kidney and plasma were increased by a linoleic acid free diet and decreased by indomethacin treatment. Linoleic Acid 66-79 renin Rattus norvegicus 4-9 636807-4 1978 During 3% anaesthesia, plasma renin activity was markedly increased in the methyldopa group and decreased in the propranolol group. Propranolol 113-124 renin Rattus norvegicus 30-35 742304-6 1978 The renin activities in the kidney and plasma were increased by a linoleic acid free diet and decreased by indomethacin treatment. Indomethacin 107-119 renin Rattus norvegicus 4-9 742304-10 1978 We conclude that the increase in the sympathetic activity, in the renin activity and in the vasoreactivity after a linoleic acid free diet has promoted the elevation of blood pressure of salt loaded rats and that these prohypertensive changes have been caused by a diminished PG biosynthesis in kidneys and blood vessels. Salts 187-191 renin Rattus norvegicus 66-71 732253-6 1978 Renin release from the isolated perfused rat kidney was increased 2--3 fold by vinblastine (10(-5) M) or colchicine (10(-4) M). Colchicine 105-115 renin Rattus norvegicus 0-5 581995-15 1978 It is concluded that the decrease in renal medullary hemodynamics of furosemide-treated rats is due to a stimulation of the renin-angiotensin system. Furosemide 69-79 renin Rattus norvegicus 124-129 732250-4 1978 A high renin content of the declamped kidney prevented major salt and fluid loss, whereas renin depletion of this kidney was accompanied by an exaggerated natriuresis and diuresis. Salts 61-65 renin Rattus norvegicus 7-12 732253-0 1978 The influence of vinblastine and colchicine on renin secretion in vivo and in vitro. Vinblastine 17-28 renin Rattus norvegicus 47-52 625013-3 1978 Pharmacological activation of the renin-angiotensin system with isoprenaline or phentolamine caused increased intake of water but did not stimulate sodium appetite in sodium-replete adrenalectomized rats, and decreased sodium appetite in sodium-depleted adrenalectomized animals.3. Isoproterenol 64-76 renin Rattus norvegicus 34-39 625013-3 1978 Pharmacological activation of the renin-angiotensin system with isoprenaline or phentolamine caused increased intake of water but did not stimulate sodium appetite in sodium-replete adrenalectomized rats, and decreased sodium appetite in sodium-depleted adrenalectomized animals.3. Phentolamine 80-92 renin Rattus norvegicus 34-39 625013-3 1978 Pharmacological activation of the renin-angiotensin system with isoprenaline or phentolamine caused increased intake of water but did not stimulate sodium appetite in sodium-replete adrenalectomized rats, and decreased sodium appetite in sodium-depleted adrenalectomized animals.3. Water 120-125 renin Rattus norvegicus 34-39 625013-7 1978 Preoptic injections of renin, renin substrate or angiotensin II into sodium-replete adrenalectomized rats which were maintained on water and 2.7% saline induced immediate thirst followed by some saline intake. Sodium Chloride 146-152 renin Rattus norvegicus 23-28 625013-7 1978 Preoptic injections of renin, renin substrate or angiotensin II into sodium-replete adrenalectomized rats which were maintained on water and 2.7% saline induced immediate thirst followed by some saline intake. Sodium Chloride 195-201 renin Rattus norvegicus 23-28 625013-11 1978 In conclusion, peripheral activation of the renin-angiotensin system stimulates water intake but has no direct effect on sodium appetite. Water 80-85 renin Rattus norvegicus 44-49 732253-0 1978 The influence of vinblastine and colchicine on renin secretion in vivo and in vitro. Colchicine 33-43 renin Rattus norvegicus 47-52 732253-1 1978 The effect of the microtubule inhibitors colchicine and vinblastine on renin release in vivo and in vitro was studied. Colchicine 41-51 renin Rattus norvegicus 71-76 732253-7 1978 The maximal response of renin release to isoproterenol (10(-7) M) was not changed when vinblastine (10(-5) M) or colchicine (10(-4) M) were present in the perfusion medium. Isoproterenol 41-54 renin Rattus norvegicus 24-29 732253-1 1978 The effect of the microtubule inhibitors colchicine and vinblastine on renin release in vivo and in vitro was studied. Vinblastine 56-67 renin Rattus norvegicus 71-76 732253-3 1978 of colchicine or vinblastine to furosemide treated rats on a low salt diet resulted in a decrease of plasma renin as well as plasma angiotensinogen concentration during a 5 h observation period. Colchicine 3-13 renin Rattus norvegicus 108-113 713616-0 1978 [Effect of oxprenolol and propranolol on increased plasma renin activity in rats after physical exertion]. Oxprenolol 11-21 renin Rattus norvegicus 58-63 732253-3 1978 of colchicine or vinblastine to furosemide treated rats on a low salt diet resulted in a decrease of plasma renin as well as plasma angiotensinogen concentration during a 5 h observation period. Vinblastine 17-28 renin Rattus norvegicus 108-113 732253-3 1978 of colchicine or vinblastine to furosemide treated rats on a low salt diet resulted in a decrease of plasma renin as well as plasma angiotensinogen concentration during a 5 h observation period. Furosemide 32-42 renin Rattus norvegicus 108-113 732253-3 1978 of colchicine or vinblastine to furosemide treated rats on a low salt diet resulted in a decrease of plasma renin as well as plasma angiotensinogen concentration during a 5 h observation period. Salts 65-69 renin Rattus norvegicus 108-113 732253-4 1978 Renin release from rat kidney slices was diminished by vinblastine (5 x 10(-5) M), when basal or stimulated (by isobutylmethylxanthine and isoproterenol) renin release was measured. Vinblastine 55-66 renin Rattus norvegicus 0-5 732253-4 1978 Renin release from rat kidney slices was diminished by vinblastine (5 x 10(-5) M), when basal or stimulated (by isobutylmethylxanthine and isoproterenol) renin release was measured. Vinblastine 55-66 renin Rattus norvegicus 154-159 732253-4 1978 Renin release from rat kidney slices was diminished by vinblastine (5 x 10(-5) M), when basal or stimulated (by isobutylmethylxanthine and isoproterenol) renin release was measured. 1-Methyl-3-isobutylxanthine 112-134 renin Rattus norvegicus 0-5 732253-4 1978 Renin release from rat kidney slices was diminished by vinblastine (5 x 10(-5) M), when basal or stimulated (by isobutylmethylxanthine and isoproterenol) renin release was measured. Isoproterenol 139-152 renin Rattus norvegicus 0-5 732253-6 1978 Renin release from the isolated perfused rat kidney was increased 2--3 fold by vinblastine (10(-5) M) or colchicine (10(-4) M). Vinblastine 79-90 renin Rattus norvegicus 0-5 713616-0 1978 [Effect of oxprenolol and propranolol on increased plasma renin activity in rats after physical exertion]. Propranolol 26-37 renin Rattus norvegicus 58-63 745630-1 1978 Renin substrate concentrations and the release of renin in response to the rapid removal of 15 ml/kg weight blood or subcutaneous administration of 500 microgram/kg body weight isoproterenol were measured in control rats and animals recovering from prior myohemoglobinuric acute renal failure (recovery rats). Isoproterenol 177-190 renin Rattus norvegicus 50-55 215928-9 1978 These data indicate that sodium deprivation enhances the sensitivity of the renin-secreting cells to catecholamine stimulation, and are consistent with the hypothesis that the increase in renin secretion produced by NE is mediated via cyclic AMP. Cyclic AMP 235-245 renin Rattus norvegicus 76-81 215928-9 1978 These data indicate that sodium deprivation enhances the sensitivity of the renin-secreting cells to catecholamine stimulation, and are consistent with the hypothesis that the increase in renin secretion produced by NE is mediated via cyclic AMP. Cyclic AMP 235-245 renin Rattus norvegicus 188-193 619300-0 1978 Serial studies of the renin system in rats with glycerol-induced renal failure. Glycerol 48-56 renin Rattus norvegicus 22-27 215928-0 1978 Effect of norepinephrine on renin release and the cyclic AMP content of rat kidney slices: modification by sodium deficiency and alpha-adrenergic blockade. Norepinephrine 10-24 renin Rattus norvegicus 28-33 215928-1 1978 The effect of L-norepinephrine (NE) on renin release by slices of kidney cortex from sodium-replete and sodium-deficient rats was studied in vitro. Norepinephrine 14-30 renin Rattus norvegicus 39-44 215928-1 1978 The effect of L-norepinephrine (NE) on renin release by slices of kidney cortex from sodium-replete and sodium-deficient rats was studied in vitro. Sodium 85-91 renin Rattus norvegicus 39-44 215928-2 1978 The rate of renin release by slices from sodium-deficient rats in the absence of added NE increased in proportion to the length of dietary sodium restriction and was significantly greater at all times than release by slices from sodium-replete animals. Sodium 41-47 renin Rattus norvegicus 12-17 215928-2 1978 The rate of renin release by slices from sodium-deficient rats in the absence of added NE increased in proportion to the length of dietary sodium restriction and was significantly greater at all times than release by slices from sodium-replete animals. Sodium 139-145 renin Rattus norvegicus 12-17 215928-2 1978 The rate of renin release by slices from sodium-deficient rats in the absence of added NE increased in proportion to the length of dietary sodium restriction and was significantly greater at all times than release by slices from sodium-replete animals. Sodium 139-145 renin Rattus norvegicus 12-17 215928-8 1978 A dose-response relationship between the changes in renin release and cyclic AMP content was not observed. Cyclic AMP 70-80 renin Rattus norvegicus 52-57 215928-9 1978 These data indicate that sodium deprivation enhances the sensitivity of the renin-secreting cells to catecholamine stimulation, and are consistent with the hypothesis that the increase in renin secretion produced by NE is mediated via cyclic AMP. Sodium 25-31 renin Rattus norvegicus 76-81 215928-9 1978 These data indicate that sodium deprivation enhances the sensitivity of the renin-secreting cells to catecholamine stimulation, and are consistent with the hypothesis that the increase in renin secretion produced by NE is mediated via cyclic AMP. Sodium 25-31 renin Rattus norvegicus 188-193 215928-9 1978 These data indicate that sodium deprivation enhances the sensitivity of the renin-secreting cells to catecholamine stimulation, and are consistent with the hypothesis that the increase in renin secretion produced by NE is mediated via cyclic AMP. Catecholamines 101-114 renin Rattus norvegicus 76-81 745630-5 1978 Isoproternol injection in recovery rats caused a somewhat greater blood pressure fall and almost twice the rise in plasma renin concentration observed in control rats. isoproternol 0-12 renin Rattus norvegicus 122-127 745631-1 1978 These experiments were performed to test if heparin inhibits the production of angiotensin I from rat renin substrate acted upon by either rat or hog renin. Heparin 44-51 renin Rattus norvegicus 102-107 745631-1 1978 These experiments were performed to test if heparin inhibits the production of angiotensin I from rat renin substrate acted upon by either rat or hog renin. Heparin 44-51 renin Rattus norvegicus 150-155 745631-4 1978 Heparin (0 and 50 units/ml, final concentration) was added to rat plasma which contained renin and renin substrate. Heparin 0-7 renin Rattus norvegicus 89-94 745631-4 1978 Heparin (0 and 50 units/ml, final concentration) was added to rat plasma which contained renin and renin substrate. Heparin 0-7 renin Rattus norvegicus 99-104 599196-3 1977 Ligation of the inferior vena cava and administration of isoproterenol have been shown to stimulate renin secretion and to augment water intake in rats. Isoproterenol 57-70 renin Rattus norvegicus 100-105 589929-2 1977 We have examined the response of renin to chronic low and high sodium chloride intake in rats with transplanted phaeochromocytoma. Sodium Chloride 63-78 renin Rattus norvegicus 33-38 914834-6 1977 By the use of Na-tetrathionate it was possible to preserve the renin activity of hog kidney exclusively in the high molecular weight form. na-tetrathionate 14-30 renin Rattus norvegicus 63-68 914834-7 1977 Similarly, using N-ethylmaleimide it was shown that a similar high molecular weight form of renin is the exclusive form present in rat kidney. Ethylmaleimide 17-33 renin Rattus norvegicus 92-97 415132-2 1977 The effects of external medium calcium concentration, the ionophore A(23187) and lanthanum on the rate of renin release in vitro were studied with particular emphasis on results obtained from isolated superfused glomeruli of rat kidneys.2. Lanthanum 81-90 renin Rattus norvegicus 106-111 415132-3 1977 The response to reduction in superfusate calcium concentration from 2 mM was a graded and reversible increase in the rate of renin release. Calcium 41-48 renin Rattus norvegicus 125-130 415132-6 1977 Renin release from kidney cortical slices similarly increased in response to calcium-free incubation medium.3. Calcium 77-84 renin Rattus norvegicus 0-5 415132-11 1977 Addition of lanthanum (1 or 0.05 mM) to calcium-containing as well as calcium-free superfusate resulted in a significant depression of renin release. Lanthanum 12-21 renin Rattus norvegicus 135-140 415132-11 1977 Addition of lanthanum (1 or 0.05 mM) to calcium-containing as well as calcium-free superfusate resulted in a significant depression of renin release. Calcium 40-47 renin Rattus norvegicus 135-140 415132-11 1977 Addition of lanthanum (1 or 0.05 mM) to calcium-containing as well as calcium-free superfusate resulted in a significant depression of renin release. Calcium 70-77 renin Rattus norvegicus 135-140 415132-13 1977 It is concluded that calcium influences renin release by a direct action on the juxtaglomerular cells. Calcium 21-28 renin Rattus norvegicus 40-45 415132-14 1977 The data support the previous suggestion that basal renin release is a function of active, calcium-dependent cell volume regulation - swelling causing an increase in the release; and further suggest that membrane-bound calcium has a direct effect on the cell membrane permeability to renin.6. Calcium 91-98 renin Rattus norvegicus 52-57 415132-14 1977 The data support the previous suggestion that basal renin release is a function of active, calcium-dependent cell volume regulation - swelling causing an increase in the release; and further suggest that membrane-bound calcium has a direct effect on the cell membrane permeability to renin.6. Calcium 91-98 renin Rattus norvegicus 284-289 415132-14 1977 The data support the previous suggestion that basal renin release is a function of active, calcium-dependent cell volume regulation - swelling causing an increase in the release; and further suggest that membrane-bound calcium has a direct effect on the cell membrane permeability to renin.6. Calcium 219-226 renin Rattus norvegicus 52-57 415132-14 1977 The data support the previous suggestion that basal renin release is a function of active, calcium-dependent cell volume regulation - swelling causing an increase in the release; and further suggest that membrane-bound calcium has a direct effect on the cell membrane permeability to renin.6. Calcium 219-226 renin Rattus norvegicus 284-289 415132-15 1977 The results exclude that calcium-stimulated exocytosis is responsible for basal renin release from the juxtaglomerular cells adhering to isolated glomeruli. Calcium 25-32 renin Rattus norvegicus 80-85 920810-4 1977 Plasma renin and angiotensin II concentrations declined under the influence of both steroids. Steroids 84-92 renin Rattus norvegicus 7-31 589929-4 1977 Phaeochromocytoma suppressed the usual elevated plasma renin activity observed during sodium deprivation. Sodium 86-92 renin Rattus norvegicus 55-60 589929-6 1977 Studies in isolated perfused kidneys indicated that sodium-deprived phaeochromocytoma rats released substantially less renin than sodium-deprived control rats despite an almost identical renal renin content in both sets of animals. Sodium 52-58 renin Rattus norvegicus 119-124 589929-9 1977 Additional experiments demonstrated that chronic sodium chloride loading suppressed plasma renin activity, renin content and renin release in both phaeochromocytoma and control rats. Sodium Chloride 49-64 renin Rattus norvegicus 91-96 909077-0 1977 Renin inhibitory effect of 2-[4-(4"-chlorophenoxy)phenoxyacetylamino]-ethylphosphorylethanolamine (PE-104) in vitro and in vivo. PE 104 27-97 renin Rattus norvegicus 0-5 589929-9 1977 Additional experiments demonstrated that chronic sodium chloride loading suppressed plasma renin activity, renin content and renin release in both phaeochromocytoma and control rats. Sodium Chloride 49-64 renin Rattus norvegicus 107-112 909077-0 1977 Renin inhibitory effect of 2-[4-(4"-chlorophenoxy)phenoxyacetylamino]-ethylphosphorylethanolamine (PE-104) in vitro and in vivo. PE 104 99-105 renin Rattus norvegicus 0-5 909077-1 1977 The renin inhibitory activity of 2-[4-(4"-chlorophenoxy)phenoxyacetylamino]ethylphosphorylethanolamine (PE-104) was examined in vitro and in vivo. PE 104 33-102 renin Rattus norvegicus 4-9 589929-9 1977 Additional experiments demonstrated that chronic sodium chloride loading suppressed plasma renin activity, renin content and renin release in both phaeochromocytoma and control rats. Sodium Chloride 49-64 renin Rattus norvegicus 107-112 909077-1 1977 The renin inhibitory activity of 2-[4-(4"-chlorophenoxy)phenoxyacetylamino]ethylphosphorylethanolamine (PE-104) was examined in vitro and in vivo. PE 104 104-110 renin Rattus norvegicus 4-9 589929-12 1977 We conclude that noradrenaline-secreting phaeochromocytoma impairs the response of plasma renin activity in the rat by inhibiting renin release. Norepinephrine 17-30 renin Rattus norvegicus 90-95 909077-4 1977 Data concerning the relationship between renin inhibitory activity and the chemical structure indicated that the whole structure was required for inhibitory activity of PE-104. PE 104 169-175 renin Rattus norvegicus 41-46 909077-6 1977 In normotensive rats, infusion of PE-104 (20 mg/kg/min) abolished increases in blood pressure, plasma renin activity and plasma angiotensin I concentration after injection of renin. PE 104 34-40 renin Rattus norvegicus 102-107 909077-6 1977 In normotensive rats, infusion of PE-104 (20 mg/kg/min) abolished increases in blood pressure, plasma renin activity and plasma angiotensin I concentration after injection of renin. PE 104 34-40 renin Rattus norvegicus 175-180 589929-12 1977 We conclude that noradrenaline-secreting phaeochromocytoma impairs the response of plasma renin activity in the rat by inhibiting renin release. Norepinephrine 17-30 renin Rattus norvegicus 130-135 909077-7 1977 In two kidney model renal hypertensive rats, infusion of PE-104 resulted in decreases in blood pressure, plasma renin activity and plasma angiotensin I concentration. pe 57-59 renin Rattus norvegicus 112-117 910921-6 1977 These results are inconsistent with the hypothesis that renal renin content is directly related to the severity of glycerol-induced renal failure in rats. Glycerol 115-123 renin Rattus norvegicus 62-67 198217-1 1977 The intrarenal effect of the alpha-receptor agonist phenylephrine on renin secretion was examined in the isolated rat kidney. Phenylephrine 52-65 renin Rattus norvegicus 69-74 902352-0 1977 Vasopressin and renin in glycerol-induced acute renal failure in the rat. Glycerol 25-33 renin Rattus norvegicus 16-21 902371-1 1977 The effect of ethinyl estradiol (EE2) and dexamethasone (Dex) upon plasma renin substrate (PRS) was studied in rats in relation to sexual maturation and pituitary function. Ethinyl Estradiol 33-36 renin Rattus norvegicus 74-79 902371-1 1977 The effect of ethinyl estradiol (EE2) and dexamethasone (Dex) upon plasma renin substrate (PRS) was studied in rats in relation to sexual maturation and pituitary function. Dexamethasone 42-55 renin Rattus norvegicus 74-79 902371-1 1977 The effect of ethinyl estradiol (EE2) and dexamethasone (Dex) upon plasma renin substrate (PRS) was studied in rats in relation to sexual maturation and pituitary function. Dexamethasone 57-60 renin Rattus norvegicus 74-79 199532-2 1977 The beta-sympathomimetic amine isoprenaline increases the plasma renin concentration by a stimulation of beta-receptors which control renin release. beta-sympathomimetic amine 4-30 renin Rattus norvegicus 65-70 199532-2 1977 The beta-sympathomimetic amine isoprenaline increases the plasma renin concentration by a stimulation of beta-receptors which control renin release. beta-sympathomimetic amine 4-30 renin Rattus norvegicus 134-139 199532-2 1977 The beta-sympathomimetic amine isoprenaline increases the plasma renin concentration by a stimulation of beta-receptors which control renin release. Isoproterenol 31-43 renin Rattus norvegicus 65-70 199532-2 1977 The beta-sympathomimetic amine isoprenaline increases the plasma renin concentration by a stimulation of beta-receptors which control renin release. Isoproterenol 31-43 renin Rattus norvegicus 134-139 199532-4 1977 In these investigations it has been tested to see whether the catecholamines released by this activation modulate renin release by stimulation of certain alpha-receptors. Catecholamines 62-76 renin Rattus norvegicus 114-119 199532-5 1977 Pretreatment of rats with reserpine or with the ganglionic blocking agent Trimethidinium enhanced the increase in plasma renin concentration induced by isoprenaline. Reserpine 26-35 renin Rattus norvegicus 121-126 199532-5 1977 Pretreatment of rats with reserpine or with the ganglionic blocking agent Trimethidinium enhanced the increase in plasma renin concentration induced by isoprenaline. trimethidinium 74-88 renin Rattus norvegicus 121-126 916500-10 1977 Thus, DTT ameliorates the course of heavy metal-induced ARF, and this effect is associated with prevention of heavy metal-induced alterations in sodium excretion and renin-angiotensin system activity. Dithiothreitol 6-9 renin Rattus norvegicus 166-171 199532-5 1977 Pretreatment of rats with reserpine or with the ganglionic blocking agent Trimethidinium enhanced the increase in plasma renin concentration induced by isoprenaline. Isoproterenol 152-164 renin Rattus norvegicus 121-126 199532-7 1977 Renal denervation also increased the effect of isoprenaline on plasma renin concentration. Isoproterenol 47-59 renin Rattus norvegicus 70-75 199532-8 1977 It is concluded that catecholamines released from the sympathetic nervous system can decrease renin secretion by an activation of certain alpha-receptors. Catecholamines 21-35 renin Rattus norvegicus 94-99 198679-0 1977 alpha-Adrenoceptor-mediated inhibitory effect of the sympathetic nervous system on the isoprenaline-induced increase in plasma renin concentration. Isoproterenol 87-99 renin Rattus norvegicus 127-132 916500-10 1977 Thus, DTT ameliorates the course of heavy metal-induced ARF, and this effect is associated with prevention of heavy metal-induced alterations in sodium excretion and renin-angiotensin system activity. Metals 116-121 renin Rattus norvegicus 166-171 198679-1 1977 The importance of the sympatho-adrenal system for the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats Ganglionic blockade by trimethidinium (10 mg kg-1) increased the dose-dependent elevation of plasma renin concentration induced by isoprenaline (0.03-0.48 microgram kg-1 min-1). Isoproterenol 54-66 renin Rattus norvegicus 94-99 198679-1 1977 The importance of the sympatho-adrenal system for the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats Ganglionic blockade by trimethidinium (10 mg kg-1) increased the dose-dependent elevation of plasma renin concentration induced by isoprenaline (0.03-0.48 microgram kg-1 min-1). Isoproterenol 54-66 renin Rattus norvegicus 249-254 198679-1 1977 The importance of the sympatho-adrenal system for the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats Ganglionic blockade by trimethidinium (10 mg kg-1) increased the dose-dependent elevation of plasma renin concentration induced by isoprenaline (0.03-0.48 microgram kg-1 min-1). trimethidinium 172-186 renin Rattus norvegicus 94-99 198679-1 1977 The importance of the sympatho-adrenal system for the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats Ganglionic blockade by trimethidinium (10 mg kg-1) increased the dose-dependent elevation of plasma renin concentration induced by isoprenaline (0.03-0.48 microgram kg-1 min-1). trimethidinium 172-186 renin Rattus norvegicus 249-254 198679-2 1977 Also treatment of the rats with guanethidine (6 mg kg-1) or reserpine (2.5 mg kg-1, given 16 and 7 h prior to the experiments) further increased the effect of isoprenaline (0.5 microgram kg-1 min-1) on plasma renin concentration. Guanethidine 32-44 renin Rattus norvegicus 209-214 198679-2 1977 Also treatment of the rats with guanethidine (6 mg kg-1) or reserpine (2.5 mg kg-1, given 16 and 7 h prior to the experiments) further increased the effect of isoprenaline (0.5 microgram kg-1 min-1) on plasma renin concentration. Reserpine 60-69 renin Rattus norvegicus 209-214 16742-0 1977 The effects of dopamine on renin release in vitro. Dopamine 15-23 renin Rattus norvegicus 27-32 198679-2 1977 Also treatment of the rats with guanethidine (6 mg kg-1) or reserpine (2.5 mg kg-1, given 16 and 7 h prior to the experiments) further increased the effect of isoprenaline (0.5 microgram kg-1 min-1) on plasma renin concentration. Isoproterenol 159-171 renin Rattus norvegicus 209-214 198679-3 1977 Unilateral renal denervation combined with contralateral nephrectomy doubled the effect of the beta-sympathomimetic amine on renin release. beta-sympathomimetic amine 95-121 renin Rattus norvegicus 125-130 19116-2 1977 2 It provokes hypertension in normotensive rats and does not prevent arterial hypertension in SHR rats, although it does prevent the renin secretion normally induced by isoprenaline infusion. Isoproterenol 169-181 renin Rattus norvegicus 133-138 16742-2 1977 In the presence of an antioxidant, ascorbic acid (6 X 10(-4)M), a significant dose-related stimulation of renin release was observed with addition of 10(-5)M and higher concentrations of dopamine. Ascorbic Acid 35-48 renin Rattus norvegicus 106-111 16742-2 1977 In the presence of an antioxidant, ascorbic acid (6 X 10(-4)M), a significant dose-related stimulation of renin release was observed with addition of 10(-5)M and higher concentrations of dopamine. Dopamine 187-195 renin Rattus norvegicus 106-111 16742-3 1977 When the monoamine oxidase inhibitor, pheniprazine (1 X 10(-5)M) was added, significant, dose-related stimulation of renin release was observed with 10(-8)M and higher concentrations of dopamine. pheniprazine 38-50 renin Rattus norvegicus 117-122 16742-3 1977 When the monoamine oxidase inhibitor, pheniprazine (1 X 10(-5)M) was added, significant, dose-related stimulation of renin release was observed with 10(-8)M and higher concentrations of dopamine. Dopamine 186-194 renin Rattus norvegicus 117-122 16742-4 1977 Dopamine-induced renin release was not inhibited by the presence of the alpha-adrenergic antagonist, phentolamine (9 X 10(-4)M), the dopaminergic antagonist, haloperidol (5 X 10(-5)M) or the neural uptake inhibitor, cocaine (1 X 10(-5)M). Dopamine 0-8 renin Rattus norvegicus 17-22 16742-5 1977 However, the presence of the beta-adrenergic antagonist, propranolol (2 X 10(-4)M) completely inhibited dopamine-induced renin release. Propranolol 57-68 renin Rattus norvegicus 121-126 877130-0 1977 Testosterone effect on renin system in rats. Testosterone 0-12 renin Rattus norvegicus 23-28 16742-5 1977 However, the presence of the beta-adrenergic antagonist, propranolol (2 X 10(-4)M) completely inhibited dopamine-induced renin release. Dopamine 104-112 renin Rattus norvegicus 121-126 16742-6 1977 These studies indicate that dopamine can directly stimulate renin release in the absence of effects of hemodynamic factors, alterations in sodium metabolism or release of endogenous adrenergic agents. Dopamine 28-36 renin Rattus norvegicus 60-65 16742-7 1977 Further, this direct effect of dopamine on renin release appears to be mediated by an agonistic effect on the juxtaglomerular beta receptor rather than by the presence of a specific dopaminergic receptor for renin release. Dopamine 31-39 renin Rattus norvegicus 43-48 877383-0 1977 Stimulation of renin release by prostaglandin E2. Dinoprostone 32-48 renin Rattus norvegicus 15-20 877383-1 1977 The effect of different doses of prostaglandin E2 on renin secretion in isolated perfused rat kidney has been studied. Dinoprostone 33-49 renin Rattus norvegicus 53-58 877383-2 1977 The infusion of 5 ng/ml of prostaglandin E2 produced a significant rise on renin secretion compared with control group. Dinoprostone 27-43 renin Rattus norvegicus 75-80 877383-3 1977 A dosage increase of prostaglandin E2 (10 and 50 ng/ml) produced an increase in the released renin. Dinoprostone 21-37 renin Rattus norvegicus 93-98 871165-6 1977 These observations, along with those reported previously in sodium-depleted rats, point to an important overall role for the renin-angiotensin system in the control of aldosterone secretion in the rat. Sodium 60-66 renin Rattus norvegicus 125-130 871165-6 1977 These observations, along with those reported previously in sodium-depleted rats, point to an important overall role for the renin-angiotensin system in the control of aldosterone secretion in the rat. Aldosterone 168-179 renin Rattus norvegicus 125-130 851195-0 1977 Stimulation of renin release in perfused kidney by low calcium and high magnesium. Calcium 55-62 renin Rattus norvegicus 15-20 884392-0 1977 Intrarenal stimulation of renin secretion by frusemide in the isolated kidney of the rat. Furosemide 45-54 renin Rattus norvegicus 26-31 884392-2 1977 Intrarenal infusion of frusemide markedly stimulated renin secretion in the isolated perfused kidney of the rat. Furosemide 23-32 renin Rattus norvegicus 53-58 884392-4 1977 Renin vales increased from 24+/-6 to 195+/-34 units of secretion rate (renin concentration (nmol angiotensin I/h per litre) X flow rate (ml/min)) following administration of frusemide for 8 min, compared with corresponding control values of 13 +/- 2 (P greater than 0.05) and 47 +/-18 (P less than 0.001). Furosemide 174-183 renin Rattus norvegicus 0-5 884392-4 1977 Renin vales increased from 24+/-6 to 195+/-34 units of secretion rate (renin concentration (nmol angiotensin I/h per litre) X flow rate (ml/min)) following administration of frusemide for 8 min, compared with corresponding control values of 13 +/- 2 (P greater than 0.05) and 47 +/-18 (P less than 0.001). Furosemide 174-183 renin Rattus norvegicus 71-76 884392-9 1977 These findings indicate the existence of an intrarenal site of action for frusemide on renin secretion. Furosemide 74-83 renin Rattus norvegicus 87-92 884392-12 1977 A direct effect of frusemide on the renin secreting cell is therefore suggested. Furosemide 19-28 renin Rattus norvegicus 36-41 196123-0 1977 Effect of propranolol on blood pressure and plasma renin concentration in renovascular hypertensive rats. Propranolol 10-21 renin Rattus norvegicus 51-56 196123-1 1977 The effect of chronic oral administration of propranolol (39--80 mg/Kg/day, for 21--27 days) on blood pressure, plasma renin concentration, and heart rate were studied in 2 types of renovascular hypertensive rats; one-kidney type with normal plasma renin and two-kidney type with high plasma renin. Propranolol 45-56 renin Rattus norvegicus 119-124 15457-1 1977 CaCl2 suppresses the plasma renin activity (PRA) response to Na+ deprivation in the rat. Calcium Chloride 0-5 renin Rattus norvegicus 28-33 15737-0 1977 Effect of beta-blocking agents and angiotensin II on isoproterenol-stimulated renin release from rat kidney slices. Isoproterenol 53-66 renin Rattus norvegicus 78-83 15737-2 1977 We previously demonstrated that renin release by kidney slices may be increased by beta-adrenergic agonists, and the present communication contains our results on the effects of 15 beta-blocking agents and angiotensin II on isoproterenol-stimulated renin release. Isoproterenol 224-237 renin Rattus norvegicus 32-37 15737-2 1977 We previously demonstrated that renin release by kidney slices may be increased by beta-adrenergic agonists, and the present communication contains our results on the effects of 15 beta-blocking agents and angiotensin II on isoproterenol-stimulated renin release. Isoproterenol 224-237 renin Rattus norvegicus 249-254 15737-6 1977 (3) Dose-related inhibition was observed with practolol, oxprenolol, timolol, nadolol, and atenolol at concentrations ranging from 10-8 to 10-5 m. Basal renin release was significantly (P is less than 0.01) inhibited by angiotensin II at 10-6 m, which also inhibited isoproterenol-stimulated renin release in a dose-related fashion. Nadolol 78-85 renin Rattus norvegicus 153-158 15737-6 1977 (3) Dose-related inhibition was observed with practolol, oxprenolol, timolol, nadolol, and atenolol at concentrations ranging from 10-8 to 10-5 m. Basal renin release was significantly (P is less than 0.01) inhibited by angiotensin II at 10-6 m, which also inhibited isoproterenol-stimulated renin release in a dose-related fashion. Atenolol 91-99 renin Rattus norvegicus 153-158 15737-6 1977 (3) Dose-related inhibition was observed with practolol, oxprenolol, timolol, nadolol, and atenolol at concentrations ranging from 10-8 to 10-5 m. Basal renin release was significantly (P is less than 0.01) inhibited by angiotensin II at 10-6 m, which also inhibited isoproterenol-stimulated renin release in a dose-related fashion. Atenolol 91-99 renin Rattus norvegicus 292-297 15737-6 1977 (3) Dose-related inhibition was observed with practolol, oxprenolol, timolol, nadolol, and atenolol at concentrations ranging from 10-8 to 10-5 m. Basal renin release was significantly (P is less than 0.01) inhibited by angiotensin II at 10-6 m, which also inhibited isoproterenol-stimulated renin release in a dose-related fashion. Isoproterenol 267-280 renin Rattus norvegicus 153-158 15737-8 1977 CONCLUSIONS: There are three different effects of beta-blocking agents on isoproterenol-stimulated renin release which can only partially be explained by their presently ascribed pharmacological properties. Isoproterenol 74-87 renin Rattus norvegicus 99-104 71087-0 1977 Modifications of arterial pressure and plasma renin: their effects on the norepinephrine content of hypothalamus and medulla oblongata. Norepinephrine 74-88 renin Rattus norvegicus 46-51 857966-3 1977 It is assumed that renin and erythropoietin could be regarded as two links of the same broad control system, responsible for optimum tissue oxygen supply. Oxygen 140-146 renin Rattus norvegicus 19-24 851195-0 1977 Stimulation of renin release in perfused kidney by low calcium and high magnesium. Magnesium 72-81 renin Rattus norvegicus 15-20 851195-3 1977 Renin release was inversely related to perfusate calcium concentration, whereas renin release was directly related to perfusate magnesium. Calcium 49-56 renin Rattus norvegicus 0-5 851195-3 1977 Renin release was inversely related to perfusate calcium concentration, whereas renin release was directly related to perfusate magnesium. Magnesium 128-137 renin Rattus norvegicus 80-85 851195-4 1977 Although a low calcium medium or low perfusion pressure (50 mmHg) stimulated renin release, the release was substantially greater in the sodium-deprived rats. calcium medium 15-29 renin Rattus norvegicus 77-82 837868-0 1977 Effect of acute potassium loading on plasma renin and on urinary aldosterone in rats. Potassium 16-25 renin Rattus norvegicus 44-49 851195-6 1977 It is concluded that a) low perfusate calcium and high magnesium concentrations stimulate renin release, b) kidneys removed from sodium-deprived rats released substantially more renin thatn those from sodium-loaded rats, and c) changing perfusate sodium concentration alters sodium excretion, but does not affect renin release. Calcium 38-45 renin Rattus norvegicus 90-95 851195-6 1977 It is concluded that a) low perfusate calcium and high magnesium concentrations stimulate renin release, b) kidneys removed from sodium-deprived rats released substantially more renin thatn those from sodium-loaded rats, and c) changing perfusate sodium concentration alters sodium excretion, but does not affect renin release. Magnesium 55-64 renin Rattus norvegicus 90-95 851195-6 1977 It is concluded that a) low perfusate calcium and high magnesium concentrations stimulate renin release, b) kidneys removed from sodium-deprived rats released substantially more renin thatn those from sodium-loaded rats, and c) changing perfusate sodium concentration alters sodium excretion, but does not affect renin release. Sodium 129-135 renin Rattus norvegicus 178-183 837868-6 1977 Ptasssium loading also increased plasma renin concentration which was correlated with the sodium excretion rate (r = 0.64, P less than 0.01). ptasssium 0-9 renin Rattus norvegicus 40-45 837868-6 1977 Ptasssium loading also increased plasma renin concentration which was correlated with the sodium excretion rate (r = 0.64, P less than 0.01). Sodium 90-96 renin Rattus norvegicus 40-45 851195-6 1977 It is concluded that a) low perfusate calcium and high magnesium concentrations stimulate renin release, b) kidneys removed from sodium-deprived rats released substantially more renin thatn those from sodium-loaded rats, and c) changing perfusate sodium concentration alters sodium excretion, but does not affect renin release. Sodium 129-135 renin Rattus norvegicus 178-183 616172-6 1977 The addition of 1-thyroxine to the incubation medium increased significantly (p less than 0.001) renin release by kidney slices from normal and hypothyroid rats. 1-thyroxine 16-27 renin Rattus norvegicus 97-102 402166-0 1977 The effects of EDTA and EGTA on renin secretion. Edetic Acid 15-19 renin Rattus norvegicus 32-37 402166-0 1977 The effects of EDTA and EGTA on renin secretion. Egtazic Acid 24-28 renin Rattus norvegicus 32-37 402166-2 1977 2 Both substances produced a significant increase of renin release 3 In the absence of calcium and magnesium, EDTA still increased rein release and there was now a considerable increase of perfusion pressure. Edetic Acid 110-114 renin Rattus norvegicus 53-58 402166-5 1977 6 EGTA was less effective as a renin releaser than EDTA until magnesium was removed from the perfusate. Egtazic Acid 2-6 renin Rattus norvegicus 31-36 850148-9 1977 Although the reduced dipsogenic response to isoproterenol observed in estrogen-treated rats may reflect a reduced renin secretion, drinking could not be induced in these animals by administration of renin. Isoproterenol 44-57 renin Rattus norvegicus 114-119 616179-12 1977 It is suggested that the impairment of autoregulation induced by guanethidine, propranolol or reserpine may be due to an inhibition of renin release. Guanethidine 65-77 renin Rattus norvegicus 135-140 616179-12 1977 It is suggested that the impairment of autoregulation induced by guanethidine, propranolol or reserpine may be due to an inhibition of renin release. Propranolol 79-90 renin Rattus norvegicus 135-140 616179-12 1977 It is suggested that the impairment of autoregulation induced by guanethidine, propranolol or reserpine may be due to an inhibition of renin release. Reserpine 94-103 renin Rattus norvegicus 135-140 23790-0 1977 [Effect of the beta-adrenergic blocking agent bupranolol on the plasma renin activity in normotensive rats]. Bupranolol 46-56 renin Rattus norvegicus 71-76 828872-12 1976 Indomethacin or 5,8,11,14-eicosatetraynoic acid pretreatment in vivo, and addition to the incubation medium, reduces basal as well as C20:4-stimulated renin release in vitro. Indomethacin 0-12 renin Rattus norvegicus 151-156 23790-1 1977 The effects of the beta-adrenergic blocking agent 3-tert.-butyl-amino-1-(6"-chloro-3"-methylphenoxy)-propan-2-ol hydrochloride (bupranolol; KL 255; Betadrenol) on the plasma renin activity (PRA) of normotensive rats were studied in comparison to propranolol. 3-tert.-butyl-amino-1-(6"-chloro-3"-methylphenoxy)-propan-2-ol hydrochloride 50-126 renin Rattus norvegicus 174-179 606459-4 1977 At a dose 10 mumol (3 mg) of propranolol/kg, administered by intraperitoneal injection, the onset and severity of hypertension were not affected, although plasma renin concentration was significantly lower than in the untreated hypertensive rats in the first 5 days after the operation. Propranolol 29-40 renin Rattus norvegicus 162-167 606459-6 1977 With 200 mumol (60 mg) of propranolol/kg, administered in the drinking water, peak blood pressure 5 days after aortic ligation was lower than in the untreated control rats, but plasma renin concentration was no lower than with the smaller dose. Propranolol 26-37 renin Rattus norvegicus 184-189 606459-8 1977 The development of severe hypertension despite reduction in plasma renin concentration on the low dose of propranolol suggests the participation of renal vasopressor factors other than renin in this model. Propranolol 106-117 renin Rattus norvegicus 67-72 1071582-0 1976 Stimulation of renin secretion by frusemide and diazoxide in the isolated rat kidney. Furosemide 34-43 renin Rattus norvegicus 15-20 598208-6 1977 The interrelation between the two renin systems in NaCl hypertension could not be evaluated, since exogenous factors (Na), which interfere with the kidney renin system, play a considerable role in the pathogenesis of NaCl hypertension. Sodium Chloride 51-55 renin Rattus norvegicus 34-39 194267-6 1977 Water deprivation increased plasma (Na+), hematocrit, vasopressin content and renin activity but saralasin treatment did not reduce water intake after 30 or 60 min. Water 0-5 renin Rattus norvegicus 78-83 1071718-0 1976 Renin inhibitory effect of synthetic phosphorylethanolamine (PE-104) in the rat. phosphorylethanolamine 37-59 renin Rattus norvegicus 0-5 1071718-0 1976 Renin inhibitory effect of synthetic phosphorylethanolamine (PE-104) in the rat. PE 104 61-67 renin Rattus norvegicus 0-5 1071718-2 1976 The renin inhibitory effect of 2-[4-(4"-chlorophenoxy)phenoxy - acetylamino]ethylphosphoryl-ethanolamine (PE-104) was examined both in vitro and in vivo. PE 104 31-104 renin Rattus norvegicus 4-9 1071718-2 1976 The renin inhibitory effect of 2-[4-(4"-chlorophenoxy)phenoxy - acetylamino]ethylphosphoryl-ethanolamine (PE-104) was examined both in vitro and in vivo. PE 104 106-112 renin Rattus norvegicus 4-9 1071582-0 1976 Stimulation of renin secretion by frusemide and diazoxide in the isolated rat kidney. Diazoxide 48-57 renin Rattus norvegicus 15-20 828872-12 1976 Indomethacin or 5,8,11,14-eicosatetraynoic acid pretreatment in vivo, and addition to the incubation medium, reduces basal as well as C20:4-stimulated renin release in vitro. 5,8,11,14-Eicosatetraynoic Acid 16-47 renin Rattus norvegicus 151-156 1071582-2 1976 The effect of diazoxide (17-3 micronmol min-1 g-1) and frusemide (0-12 micronmol min-1 g-1) on renin secretion was examined in the isolated perfused rat kidney. Furosemide 55-64 renin Rattus norvegicus 95-100 1071718-7 1976 In normotensive rats, infusion of PE-104 abolished the increases of blood pressure and plasma angiotensin I concentration due to renin injection. PE 104 34-40 renin Rattus norvegicus 129-134 1071582-10 1976 These observations identify an intrarenal site of action for diazoxide and frusemide on renin secretion. Diazoxide 61-70 renin Rattus norvegicus 88-93 1071623-4 1976 of renin strikingly reduced kallikrein excretion (P less than 0-01) but considerably increased sodium excretion (P less than 0-001). Sodium 95-101 renin Rattus norvegicus 3-8 1071582-10 1976 These observations identify an intrarenal site of action for diazoxide and frusemide on renin secretion. Furosemide 75-84 renin Rattus norvegicus 88-93 1071585-0 1976 Effects of aldosterone and spironolactone on arterial renin in rats. Spironolactone 27-41 renin Rattus norvegicus 54-59 1071585-6 1976 Hypertension developed in aldosterone-treated rats within 3-6 weeks and was associated with decreased plasma and renal renin values. Aldosterone 26-37 renin Rattus norvegicus 119-124 1071585-9 1976 In spironolactone-treated rats blood pressure and total aortic renin concentrations were comparable with those in the control rats. Spironolactone 3-17 renin Rattus norvegicus 63-68 1071587-8 1976 Frusemide effectively reduced blood pressure and renin at all phases. Furosemide 0-9 renin Rattus norvegicus 49-54 1071589-9 1976 The fact that both plasma renin levels and exchangeable sodium levels increase according to this method, suggests that hypertension in the two-kidney model is renin-dependent. Sodium 56-62 renin Rattus norvegicus 159-164 1071594-2 1976 In an investigation of the prolonged pressor response to renin that develops after nephrectomy, angiotensin I dose-response curves and rat renin clearances were studied in nephrectomized rats and paired sham-nephrectomized control animals under pentobarbitone anaesthesia. Pentobarbital 245-259 renin Rattus norvegicus 57-62 1071718-10 1976 These observations confirm that PE-104 is a renin inhibitor. PE 104 32-38 renin Rattus norvegicus 44-49 1071719-10 1976 Decreasing sodium concentration from 140 to 110 mol/l with constant osmolarity of 305 mosmol/l stimulated renin release by a direct effect on juxtaglomerular cells. Sodium 11-17 renin Rattus norvegicus 106-111 1071719-12 1976 Catecholamines stimulated renin release in vitro in proportion to the potency of their action on beta-adrenoreceptors. Catecholamines 0-14 renin Rattus norvegicus 26-31 15763-11 1976 Kidney slices from the adrenalectomized salt-depleted rats released more renin than control slices. Salts 40-44 renin Rattus norvegicus 73-78 1071628-0 1976 Renin-angiotensin and kallikrein-kinin systems in sodium homeostasis and hypertension in rats. Sodium 50-56 renin Rattus norvegicus 0-5 1071595-4 1976 Des-angiotensin substrate was prepared from the purified angiotensinogen preparation by reaction with immobilized hog renin (coupled to Sepharose). Sepharose 136-145 renin Rattus norvegicus 118-123 1071628-4 1976 Rats given a sodium load (NaCl solution, 20 g/l, to drink) for 28 days showed acute and prolonged significant falls in urinary kallikrein excretion associated with suppression of plasma renin and angiotensin. Sodium 13-19 renin Rattus norvegicus 186-191 1071639-2 1976 Renal hypertensive rats with a normal or suppressed activity of the renin-angiotensin system develop vascular lesions which are similar to those observed in spontaneously hypertensive rats on high sodium diet. Sodium 197-203 renin Rattus norvegicus 68-73 140036-11 1976 Plasma renin activity was unaffected by NGFAS treatment and increased by 6-hydroxydopamine. Oxidopamine 73-90 renin Rattus norvegicus 7-12 1071628-4 1976 Rats given a sodium load (NaCl solution, 20 g/l, to drink) for 28 days showed acute and prolonged significant falls in urinary kallikrein excretion associated with suppression of plasma renin and angiotensin. nacl solution 26-39 renin Rattus norvegicus 186-191 1071662-2 1976 The hypotensive effect of propranolol and its correlation with the changes in heart rate, plasma volume and plasma renin activity produced by this drug were studied in normotensive rats and in rats with spontaneous, renovascular and deoxycorticosterone-induced hypertension. Propranolol 26-37 renin Rattus norvegicus 115-120 1071669-0 1976 Vascular lesions in hypertensive rats under salt loading: kidney renin and lysosomal enzymes. Salts 44-48 renin Rattus norvegicus 65-70 1071669-4 1976 Kidney renin activity was low during high salt loading; the kidney renin activity of rats with hypertensive renal vascular lesions was moderately elevated. Salts 42-46 renin Rattus norvegicus 7-12 1071628-6 1976 Conversely sodium-depleted rats showed increases in urinary kallikrein excretion, associated with rises in plasma renin and angiotensin. Sodium 11-17 renin Rattus norvegicus 114-119 1071628-10 1976 The diuresis and natriuresis induced by frusemide in rats was associated with increased urinary kallikrein excretion and acute rises in plasma renin. Furosemide 40-49 renin Rattus norvegicus 143-148 186664-2 1976 Animals on a sodium-deficient diet had a significant decrease of serum sodium levels with a concomitant increase of renal renin granules. Sodium 13-19 renin Rattus norvegicus 122-127 1017945-9 1976 Plasma renin activity was similar in the saline-loaded rats in both the toxic and anoxic models. Sodium Chloride 41-47 renin Rattus norvegicus 7-12 978043-12 1976 Sodium restriction stimulated the renin angiotensin system markedly, whereas high sodium intake suppressed it. Sodium 0-6 renin Rattus norvegicus 34-39 976493-7 1976 These findings provide evidence that the renin--angiotensin system is an important control mechanism for aldosterone biosynthesis in the rat. Aldosterone 105-116 renin Rattus norvegicus 41-46 991924-0 1976 Suppression of renin secretion in the isolated rat kidney by cycloheximide. Cycloheximide 61-74 renin Rattus norvegicus 15-20 991924-1 1976 The effect of cycloheximide, an inhibitor of protein synthesis, on basal and stimulated renin secretion was examined in the isolated perfused rat kidney. Cycloheximide 14-27 renin Rattus norvegicus 88-93 991924-3 1976 Both basal renin secretion and the response to intrarenal infusion of isoprenaline (0.06 nmol/min/g) or glucagon (0.1 nmol/min/g) were consistently reduced in the cycloheximide-treated group, suggesting dependence of these processes on protein synthesis. Cycloheximide 163-176 renin Rattus norvegicus 11-16 1013157-0 1976 Effect of timolol on hydralazine-induced increase in plasma renin activity in spontaneously hypertensive and normotensive rats. Timolol 10-17 renin Rattus norvegicus 60-65 1013157-0 1976 Effect of timolol on hydralazine-induced increase in plasma renin activity in spontaneously hypertensive and normotensive rats. Hydralazine 21-32 renin Rattus norvegicus 60-65 1015916-0 1976 Effect of some antihypertensive drugs and catecholamine depletors on the plasma renin activity in the rat. Catecholamines 42-55 renin Rattus norvegicus 80-85 1015916-1 1976 The effect of some antihypertensive drugs and catecholamine depletors on the plasma renin activity (PRA) has been investigated in the rat. Catecholamines 46-59 renin Rattus norvegicus 84-89 993320-8 1976 Two steroids, 16beta-hydroxy-dehydroepiandrosterone and 16-oxo-androstenediol, recently shown to have sodium-retaining activity in the rat, and also implicated in low-renin "essential" hypertension in man, showed no competitive binding activity. Steroids 4-12 renin Rattus norvegicus 167-172 993320-8 1976 Two steroids, 16beta-hydroxy-dehydroepiandrosterone and 16-oxo-androstenediol, recently shown to have sodium-retaining activity in the rat, and also implicated in low-renin "essential" hypertension in man, showed no competitive binding activity. 3 beta,17 beta-dihydroxyandrost-5-en-16-one 56-77 renin Rattus norvegicus 167-172 993320-8 1976 Two steroids, 16beta-hydroxy-dehydroepiandrosterone and 16-oxo-androstenediol, recently shown to have sodium-retaining activity in the rat, and also implicated in low-renin "essential" hypertension in man, showed no competitive binding activity. Sodium 102-108 renin Rattus norvegicus 167-172 978043-13 1976 After subtotal nephrectomy, elevation of blood pressure, renal hypertrophy, and suppression of the renin-angiotensin system are closely related to sodium intake. Sodium 147-153 renin Rattus norvegicus 99-104 989773-6 1976 When diazoxide was injected with the renin extract into hypoxic nephrectomized rats, the vasopressor effect of renin was abolished for 4 hours, and the plasma Ep levels were significantly lower than those of hypoxic nephrectomized animals injected only with renin, Injection of angiotensin II into anephric, hypoxic rats had an effect comparable to that of renin on extrarenal Ep roduction. Diazoxide 5-14 renin Rattus norvegicus 37-42 989773-6 1976 When diazoxide was injected with the renin extract into hypoxic nephrectomized rats, the vasopressor effect of renin was abolished for 4 hours, and the plasma Ep levels were significantly lower than those of hypoxic nephrectomized animals injected only with renin, Injection of angiotensin II into anephric, hypoxic rats had an effect comparable to that of renin on extrarenal Ep roduction. Diazoxide 5-14 renin Rattus norvegicus 111-116 989773-6 1976 When diazoxide was injected with the renin extract into hypoxic nephrectomized rats, the vasopressor effect of renin was abolished for 4 hours, and the plasma Ep levels were significantly lower than those of hypoxic nephrectomized animals injected only with renin, Injection of angiotensin II into anephric, hypoxic rats had an effect comparable to that of renin on extrarenal Ep roduction. Diazoxide 5-14 renin Rattus norvegicus 111-116 989773-6 1976 When diazoxide was injected with the renin extract into hypoxic nephrectomized rats, the vasopressor effect of renin was abolished for 4 hours, and the plasma Ep levels were significantly lower than those of hypoxic nephrectomized animals injected only with renin, Injection of angiotensin II into anephric, hypoxic rats had an effect comparable to that of renin on extrarenal Ep roduction. Diazoxide 5-14 renin Rattus norvegicus 111-116 1036260-2 1976 The content of angiotensin I and the activity of renin in the blood plasm aldosterone concentration in the peripheral blood plasma considerably. Aldosterone 74-85 renin Rattus norvegicus 49-54 984192-1 1976 To evaluate the contribution of chloride to NaCl- and KCl-induced renin inhibition, renin responses to NaCl or NaHCO3 and to KCl or KHCO3 loading were compared in NaCl-deprived rats. Sodium Bicarbonate 111-117 renin Rattus norvegicus 84-89 984192-3 1976 Plasma renin activity (PRA) in NaCl-loaded (16.5 ng/ml per h +/- 4.4 SE), but not in NaHCO3-loaded rats (57.2 +/- 9.8), was lower (P less than 0.005) than in NaCl-deprived controls (44.8 +/- 4.7). Sodium Chloride 31-35 renin Rattus norvegicus 7-12 984192-3 1976 Plasma renin activity (PRA) in NaCl-loaded (16.5 ng/ml per h +/- 4.4 SE), but not in NaHCO3-loaded rats (57.2 +/- 9.8), was lower (P less than 0.005) than in NaCl-deprived controls (44.8 +/- 4.7). Sodium Chloride 158-162 renin Rattus norvegicus 7-12 984192-4 1976 Renal renin content (RRC) of NaCl but not of NaHCO3-drinking animals was also decreased (P less than 0.02). Sodium Chloride 29-33 renin Rattus norvegicus 6-11 984192-8 1976 The failure of NaHCO3 and KHCO3 to inhibit renin suggests a role for chloride in mediating the renin responses to Na+ and K+. Chlorides 69-77 renin Rattus norvegicus 95-100 965491-7 1976 The adrenals of normal rats infused acutely with synthetic angiotensin II, or anesthetized with ether or sodium pentobarbital, which markedly increased plasma renin activity, contained fewer angiotensin receptors. Ether 96-101 renin Rattus norvegicus 159-164 988755-4 1976 Prior treatment with propranolol (approximately 2 mg/kg) reduced the renin response by approximately 50% but did not completely abolish it. Propranolol 21-32 renin Rattus norvegicus 69-74 965491-2 1976 Sodium deprivation caused marked increases in plasma renin, blood angiotensin II, and plasma aldosterone, and was accompanied by a significant increase (+74%) in the number of specific angiotensin II receptor sites per adrenal cortical cell. Sodium 0-6 renin Rattus norvegicus 53-58 965491-3 1976 High potassium intake was followed by increased serum potassium and markedly elevated plasma aldosterone, with subnormal levels of renin and angiotensin II and a 170% increase in the number of angiotensin II receptors per cell after 1 wk. Potassium 5-14 renin Rattus norvegicus 131-155 965491-6 1976 A decrease in receptor affinity was noted after 6 wk of either low sodium or low potassium intake, when the renin and angiotensin II levels were increased by 104-129%. Sodium 67-73 renin Rattus norvegicus 108-132 965491-6 1976 A decrease in receptor affinity was noted after 6 wk of either low sodium or low potassium intake, when the renin and angiotensin II levels were increased by 104-129%. Potassium 81-90 renin Rattus norvegicus 108-132 976191-0 1976 The interrelation of renin and iron binding capacity. Iron 31-35 renin Rattus norvegicus 21-26 976191-2 1976 The current experiments were designed to determine if a decrease in iron stores is the stimulus for renin production when rats are rapidly expanding their red cell volume in a hypoxic environment. Iron 68-72 renin Rattus norvegicus 100-105 976191-7 1976 Rats that were fed the low iron diet showed an increase in TIBC, an increase in serum renin and a positive correlation between serum renin and TIBC. Iron 27-31 renin Rattus norvegicus 86-91 976191-7 1976 Rats that were fed the low iron diet showed an increase in TIBC, an increase in serum renin and a positive correlation between serum renin and TIBC. Iron 27-31 renin Rattus norvegicus 133-138 976191-9 1976 When low iron diet rats were supplemented with iron, TIBC and serum renin decreased. Iron 9-13 renin Rattus norvegicus 68-73 976191-9 1976 When low iron diet rats were supplemented with iron, TIBC and serum renin decreased. Iron 47-51 renin Rattus norvegicus 68-73 965491-7 1976 The adrenals of normal rats infused acutely with synthetic angiotensin II, or anesthetized with ether or sodium pentobarbital, which markedly increased plasma renin activity, contained fewer angiotensin receptors. Pentobarbital 105-125 renin Rattus norvegicus 159-164 988556-6 1976 After two-step bilateral nephrectomy plus estradiol treatment the maximum increase in plasma renin substrate was found to be higher than that found after two-step bilateral nephrectomy, but was lower than that after simultaneous bilateral nephrectomy. Estradiol 42-51 renin Rattus norvegicus 93-98 10215-3 1976 In contrast to neurosecretory and chromaffin granules, renin granules were stabilized by Mg-ATP in ionic medium. Adenosine Triphosphate 89-95 renin Rattus norvegicus 55-60 970153-0 1976 Renal renin output during continuous intracarotid infusions of iso- and hypertonic sodium chloride solutions in the rat. Sodium Chloride 83-98 renin Rattus norvegicus 6-11 970153-4 1976 For the animals reacting with an increased sodium output a decrease in plasma renin activity was found together with an increase in glomerular filtration rate. Sodium 43-49 renin Rattus norvegicus 78-83 970477-1 1976 Control of renin release was studied in isolated rat kidneys perfused with Krebs-Henseleit solution containing albumin. Krebs-Henseleit solution 75-99 renin Rattus norvegicus 11-16 970153-6 1976 The animals not reacting with an increased sodium output had a higher initial plasma renin activity, which did not change during 1 M NaCl infusion. Sodium 43-49 renin Rattus norvegicus 85-90 970477-3 1976 Renal vasoconstriction induced by infusion of phenylephrine or methoxamine increased PRA, whereas vasodilatation by papaverine suppressed renin activity. Papaverine 116-126 renin Rattus norvegicus 138-143 966372-0 1976 Renin inhibition by synthetic phosphatidyl and phosphorylethanolamines. phosphatidyl 30-42 renin Rattus norvegicus 0-5 970477-4 1976 The increased renin activity induced by phenylephrine was blocked by high pressure or papaverine. Phenylephrine 40-53 renin Rattus norvegicus 14-19 970477-4 1976 The increased renin activity induced by phenylephrine was blocked by high pressure or papaverine. Papaverine 86-96 renin Rattus norvegicus 14-19 967887-0 1976 Direct stimulation of renin release by calcium. Calcium 39-46 renin Rattus norvegicus 22-27 967887-1 1976 Calcium directly stimulates renin release from rat kidney slices previously treated with calcium-free medium. Calcium 0-7 renin Rattus norvegicus 28-33 967887-1 1976 Calcium directly stimulates renin release from rat kidney slices previously treated with calcium-free medium. Calcium 89-96 renin Rattus norvegicus 28-33 967887-4 1976 The results suggest that the underlying mechanism of renin release may be comparable to that of catecholamine release, involving calcium-dependent and energy-dependent steps. Calcium 129-136 renin Rattus norvegicus 53-58 939004-2 1976 The role of sodium concentration, of alpha- and beta-adrenergic receptors, and of a microtubular inhibtor (vincristine) on renin release was studied in rat kidney slices in vitro. Vincristine 107-118 renin Rattus norvegicus 123-128 939004-5 1976 Lowering sodium concentration inhibited renin release by one-half, even when osmolality was kept constant. Sodium 9-15 renin Rattus norvegicus 40-45 939004-6 1976 Isoproterenol (10(-8) to 10(-5) M) stimulated renin release significantly in a partially dose-related manner. Isoproterenol 0-13 renin Rattus norvegicus 46-51 939004-8 1976 Significant (P less than 0.05) inhibition of renin release was induced by l-epinephrine or l-norepinephrine (10(-5) M). Epinephrine 74-87 renin Rattus norvegicus 45-50 939004-8 1976 Significant (P less than 0.05) inhibition of renin release was induced by l-epinephrine or l-norepinephrine (10(-5) M). Norepinephrine 91-107 renin Rattus norvegicus 45-50 990450-0 1976 [Renin-angiotensin system in the presence of altered prostaglandin synthesis]. Prostaglandins 53-66 renin Rattus norvegicus 1-6 990450-1 1976 The activity of the renin-angiotensin system was studied in experiments on rats under conditions of the inhibited prostaglandin synthesis. Prostaglandins 114-127 renin Rattus norvegicus 20-25 990450-2 1976 It was found that the injection of indometacin in non-hypertensive doses was accompanied by a substantial lowering of the plasma renin activity and of the secretory function of the juxtaglomerular apparatus of the kidneys. Indomethacin 35-46 renin Rattus norvegicus 129-134 990450-4 1976 The results of these experiments permit the assumption to be made that the renin synthesis in the juxtaglomerular apparatus was connected with the synthesis of renal prostaglanins. prostaglanins 166-179 renin Rattus norvegicus 75-80 986632-0 1976 Distal Tubule [Na+] and juxtaglomerular apparatus Renin activity in uranyl nitrate induced acute renal failure in the rat. Uranyl Nitrate 68-82 renin Rattus norvegicus 50-55 986632-6 1976 After uranyl nitrate, renin activity in S-JGA"s increased to 13.62 +/- 0.80 ng/JGA/h (P less than 0.001) at 2 h and remained elevated, 12.56 +/- 0.90 and 12.75 +/- 0.87 ng/JGA/h at 4 and 6 h. D-JGA renin activity increased (P less than 0.05) to 7.04 +/- 0.53, 6.23 +/- 0.31 and 3.44 +/- 0.33 ng/JGA/h at 2, 4 and 6 h after uranyl nitrate. Uranyl Nitrate 6-20 renin Rattus norvegicus 22-27 986632-6 1976 After uranyl nitrate, renin activity in S-JGA"s increased to 13.62 +/- 0.80 ng/JGA/h (P less than 0.001) at 2 h and remained elevated, 12.56 +/- 0.90 and 12.75 +/- 0.87 ng/JGA/h at 4 and 6 h. D-JGA renin activity increased (P less than 0.05) to 7.04 +/- 0.53, 6.23 +/- 0.31 and 3.44 +/- 0.33 ng/JGA/h at 2, 4 and 6 h after uranyl nitrate. Uranyl Nitrate 6-20 renin Rattus norvegicus 198-203 986632-6 1976 After uranyl nitrate, renin activity in S-JGA"s increased to 13.62 +/- 0.80 ng/JGA/h (P less than 0.001) at 2 h and remained elevated, 12.56 +/- 0.90 and 12.75 +/- 0.87 ng/JGA/h at 4 and 6 h. D-JGA renin activity increased (P less than 0.05) to 7.04 +/- 0.53, 6.23 +/- 0.31 and 3.44 +/- 0.33 ng/JGA/h at 2, 4 and 6 h after uranyl nitrate. Uranyl Nitrate 323-337 renin Rattus norvegicus 22-27 986632-9 1976 The association of increased JGA renin activity and increased distal [Na+] is consistent with a role for the tubuloglomerular feedback mechanism in the initiating phase of uranyl nitrate induced acute renal failure in the rat. Uranyl Nitrate 172-186 renin Rattus norvegicus 33-38 954653-2 1976 Circadian rhythms of plasma aldosterone, prolactin, and corticosterone concentrations and of serum renin activity were demonstrated during a regular sodium diet. Sodium 149-155 renin Rattus norvegicus 99-104 954653-6 1976 These data are compatible with a role for renin and ACTH, but not for prolactin, in the modulation of aldosterone secretion in the rat. Aldosterone 102-113 renin Rattus norvegicus 42-47 966372-0 1976 Renin inhibition by synthetic phosphatidyl and phosphorylethanolamines. phosphorylethanolamine 47-70 renin Rattus norvegicus 0-5 966372-1 1976 Renin inhibitory effects of about 30 kinds of newly synthesized Phosphatidyl-E and Phosphoryl-E were studied in vitro and in vivo. phosphatidyl-e 64-78 renin Rattus norvegicus 0-5 966372-1 1976 Renin inhibitory effects of about 30 kinds of newly synthesized Phosphatidyl-E and Phosphoryl-E were studied in vitro and in vivo. phosphoryl-e 83-95 renin Rattus norvegicus 0-5 988976-0 1976 Change in plasma renin substrate in lithium-intoxicated nephrectomized rats, and the effect of sodium on plasma renin and plasma renin substrate in lithium-intoxicated rats. Sodium 95-101 renin Rattus norvegicus 112-117 988976-0 1976 Change in plasma renin substrate in lithium-intoxicated nephrectomized rats, and the effect of sodium on plasma renin and plasma renin substrate in lithium-intoxicated rats. Sodium 95-101 renin Rattus norvegicus 112-117 966372-3 1976 We also confirmed that the converison from the original Phosphatidyl-E, so called prerenininhibitor, to lyso-form to exhibit renin inhibition as mentioned by Sen et al15,16 and Baggio et al.20 was not essential. phosphatidyl-e 56-70 renin Rattus norvegicus 85-90 1278112-3 1976 In studies involving gel filtration and polyacrylamide gel electrophoreis, renin granules appeared to contain an inactive form of renin that could be activated by acid treatment, had a higher apparent molecular weight than renin, and may be a more basic molecule. polyacrylamide 40-54 renin Rattus norvegicus 75-80 991834-0 1976 Effect of a spironolactone derivative (SC 14266) on Plasma renin activity in adrenal regeneration hypertension. Spironolactone 12-26 renin Rattus norvegicus 59-64 1269103-6 1976 Propranolol inhibited saralasin-induced renin release by 99% in normal rats and by 75% in sodium-depleted rats but not alter the hypotensive effect of saralasin in the latter. Propranolol 0-11 renin Rattus norvegicus 40-45 1269103-7 1976 Saralasin potentiated phentolamine-induced renin release, hypotension, and tachycardia in normal rats, and this potentiated renin release was blocked by propranolol. Phentolamine 22-34 renin Rattus norvegicus 43-48 1269103-7 1976 Saralasin potentiated phentolamine-induced renin release, hypotension, and tachycardia in normal rats, and this potentiated renin release was blocked by propranolol. Propranolol 153-164 renin Rattus norvegicus 124-129 1269103-8 1976 We conclude that a portion of saralasin-elicited renin release in sodium-depleted rats is mediated by hypotensive activation of the carotid baroreceptor reflex which increases sympathetic nervous activity in the kidney. Sodium 66-72 renin Rattus norvegicus 49-54 132667-0 1976 Effect of deoxycorticosterone acetate and 16beta-hydroxy-dehydroepiandrosterone on blood pressure and plasma renin activity of rats. Desoxycorticosterone Acetate 10-37 renin Rattus norvegicus 109-114 1269103-12 1976 This "short-loop" feed-back mechanism is closely associated with intrarenal beta-adrenergic receptors, since propranolol impaired saralasin-induced renin release under all circumstances in our experiments. Propranolol 109-120 renin Rattus norvegicus 148-153 1269114-2 1976 Administration of the male sex hormone testosterone or an anabolic steroid, such as nandrolone phenpropionate (Durabolin), induces renin activity in microsomal fraction of the submaxillary gland of the young female mouse. Testosterone 39-51 renin Rattus norvegicus 131-136 1269114-2 1976 Administration of the male sex hormone testosterone or an anabolic steroid, such as nandrolone phenpropionate (Durabolin), induces renin activity in microsomal fraction of the submaxillary gland of the young female mouse. Steroids 67-74 renin Rattus norvegicus 131-136 1269114-2 1976 Administration of the male sex hormone testosterone or an anabolic steroid, such as nandrolone phenpropionate (Durabolin), induces renin activity in microsomal fraction of the submaxillary gland of the young female mouse. nandrolone phenpropionate 84-109 renin Rattus norvegicus 131-136 1269114-2 1976 Administration of the male sex hormone testosterone or an anabolic steroid, such as nandrolone phenpropionate (Durabolin), induces renin activity in microsomal fraction of the submaxillary gland of the young female mouse. nandrolone phenpropionate 111-120 renin Rattus norvegicus 131-136 1269114-5 1976 Microsomal renin was also isolated from rat kidney disrupted by the N2 cavitation technique. Nitrogen 68-70 renin Rattus norvegicus 11-16 1269114-6 1976 The enzyme in the microsomal fraction that had been washed extensively was only partially active, but freezing and thawing or Triton X-100 activated microsomal renin. Octoxynol 126-138 renin Rattus norvegicus 160-165 940062-2 1976 The effects of different energy substrates, of low temperature, of urea, and of ouabain and ethacrynic acid were studied on the rate of renin release from viable juxtaglomerular cells during superfusion of isolated rat glomeruli. Ethacrynic Acid 92-107 renin Rattus norvegicus 136-141 940062-7 1976 Peak renin release was more prolonged and returned more slowly to control following reductions in osmolality in phosphate-Ringer than in bicarbonate-Ringer. Phosphates 112-121 renin Rattus norvegicus 5-10 940062-7 1976 Peak renin release was more prolonged and returned more slowly to control following reductions in osmolality in phosphate-Ringer than in bicarbonate-Ringer. Bicarbonates 137-148 renin Rattus norvegicus 5-10 132667-0 1976 Effect of deoxycorticosterone acetate and 16beta-hydroxy-dehydroepiandrosterone on blood pressure and plasma renin activity of rats. 16-hydroxydehydroepiandrosterone 42-79 renin Rattus norvegicus 109-114 5201-1 1976 The mechanism by which clonidine suppresses renin release was investigated in conscious rats. Clonidine 23-32 renin Rattus norvegicus 44-49 1276900-4 1976 (4) In a second series of 12 animals lesions of the subfornical organ attenuated water intake in response to a peripheral injection of renin or isoproteronol without disrupting drinking to peripheral administration of hypertonic saline or polyethylene glycol or to 24 h water deprivation. Water 81-86 renin Rattus norvegicus 135-140 938482-2 1976 On isoelectric focusing, renin from rat kidneys showed three activity peaks with pI values at pH 5.0, 5.2 and 5.4 after a purification procedure involving differential centrifugation, acidification, chromatography on Sephadex G-75 and dialysis. sephadex 217-230 renin Rattus norvegicus 25-30 5201-4 1976 Clonidine administration suppressed basal (by 68-85%), diuretic-induced (by 89%), and sympathetic nervous system-mediated (by 75-100%) renin release. Clonidine 0-9 renin Rattus norvegicus 135-140 5201-6 1976 These results indicate a peripheral site of action for suppression of renin release by clonidine. Clonidine 87-96 renin Rattus norvegicus 70-75 5201-7 1976 The alpha-adrenergic blocking drug phentolamine prevented clonidine suppression of renin release in sodium-depleted rats and was partially effective in normal rats. Phentolamine 35-47 renin Rattus norvegicus 83-88 5201-7 1976 The alpha-adrenergic blocking drug phentolamine prevented clonidine suppression of renin release in sodium-depleted rats and was partially effective in normal rats. Clonidine 58-67 renin Rattus norvegicus 83-88 5201-7 1976 The alpha-adrenergic blocking drug phentolamine prevented clonidine suppression of renin release in sodium-depleted rats and was partially effective in normal rats. Sodium 100-106 renin Rattus norvegicus 83-88 5201-8 1976 Phentolamine blocked the decrease in renin caused by clonidine in ganglion-blocked rats. Phentolamine 0-12 renin Rattus norvegicus 37-42 5201-8 1976 Phentolamine blocked the decrease in renin caused by clonidine in ganglion-blocked rats. Clonidine 53-62 renin Rattus norvegicus 37-42 5201-9 1976 Clozapine, a new neuroleptic agent with alpha-adrenergic blocking activity, or phenoxybenzamine blocked the effect of clonidine on renin release in both sodium-depleted and normal rats. Clozapine 0-9 renin Rattus norvegicus 131-136 5201-9 1976 Clozapine, a new neuroleptic agent with alpha-adrenergic blocking activity, or phenoxybenzamine blocked the effect of clonidine on renin release in both sodium-depleted and normal rats. Phenoxybenzamine 79-95 renin Rattus norvegicus 131-136 5201-9 1976 Clozapine, a new neuroleptic agent with alpha-adrenergic blocking activity, or phenoxybenzamine blocked the effect of clonidine on renin release in both sodium-depleted and normal rats. Clonidine 118-127 renin Rattus norvegicus 131-136 5201-9 1976 Clozapine, a new neuroleptic agent with alpha-adrenergic blocking activity, or phenoxybenzamine blocked the effect of clonidine on renin release in both sodium-depleted and normal rats. Sodium 153-159 renin Rattus norvegicus 131-136 5201-10 1976 After ganglionic blockade in sodium-depleted rats, clonidine caused a significantly greater suppression of renin release than did an equipressor dose of methoxamine. Clonidine 51-60 renin Rattus norvegicus 107-112 5201-11 1976 These data, combined with hemodynamic correlates, suggest that clonidine inhibits renin release by activation of an intrarenal alpha-adrenergic receptor. Clonidine 63-72 renin Rattus norvegicus 82-87 1155-4 1976 Tyramine-induced stimulation of renin release was blocked by the beta-blocking agent, propranolol (2 X 10(-4) M), and the neural uptake blocking agent, cocaine (10(-5) M), but not by the alpha-antagonist, phentolamine (9 X 10(-4) M). Phentolamine 205-217 renin Rattus norvegicus 32-37 1261210-12 1976 It is concluded that the observed findings are compatible with an action of sodium-loading on the sensitivity of the smooth muscle cell to angiotensin, on the resting of the renin-angiotensin system, on the rate of inactivation of angiotensin and on a change in initial length of the muscle fibre. Sodium 76-82 renin Rattus norvegicus 174-179 1260172-7 1976 5 The following factors, known to affect renin secretion in the kidney, i.e., hypovolaemia, sodium loading, adrenalectomy, administration of desoxycorticosterone acetate and injection of isoprenaline, had no effect on uterine renin-like activity. Isoproterenol 187-199 renin Rattus norvegicus 41-46 1260172-8 1976 6 Stilboestrol, an oestrogen, caused a significant increase of uterine renin-like activity. desacetyluvaricin 2-14 renin Rattus norvegicus 71-76 1260172-12 1976 Uterine renin activity is hormone-dependent and may be governed by the ratio, oestrogen : progesterone. Progesterone 90-102 renin Rattus norvegicus 8-13 5974-0 1976 Suppression of renin release by timolol. Timolol 32-39 renin Rattus norvegicus 15-20 5974-4 1976 Timolol also antagonized isoprenaline-induced renin release. Timolol 0-7 renin Rattus norvegicus 46-51 5974-4 1976 Timolol also antagonized isoprenaline-induced renin release. Isoproterenol 25-37 renin Rattus norvegicus 46-51 5974-10 1976 Thus, in rabbits and rats, timolol effectively depresses both basal and stimulated plasma renin levels. Timolol 27-34 renin Rattus norvegicus 90-95 938990-0 1976 The renin-angiotensin system, dietary salt, and increased sensitivity to noradrenaline in mesenteric vasculature preparations from renal/salt hypertensive rats. Norepinephrine 73-86 renin Rattus norvegicus 4-9 938990-2 1976 The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Norepinephrine 4-17 renin Rattus norvegicus 97-102 1155-2 1976 We used this system to study effects of tyramine (an indirectly acting amine capable of displacing endogenous catecholmines from sympathetic nerve endings) on renin release. Tyramine 40-48 renin Rattus norvegicus 159-164 1255521-0 1976 Effect of renin-angiotensin system on sodium intake. Sodium 38-44 renin Rattus norvegicus 10-15 1155-2 1976 We used this system to study effects of tyramine (an indirectly acting amine capable of displacing endogenous catecholmines from sympathetic nerve endings) on renin release. Amines 43-48 renin Rattus norvegicus 159-164 1155-2 1976 We used this system to study effects of tyramine (an indirectly acting amine capable of displacing endogenous catecholmines from sympathetic nerve endings) on renin release. catecholmines 110-123 renin Rattus norvegicus 159-164 1155-3 1976 Tyramine (10(-3)M) in the presence of a monoamine oxidase inhibitor (pheniprazine, 10(-5)M) and a phosphodiesterase inhibitor (theophylline, 10(-3)M) significantly (P less than 0.01) stimulated renin release when values were compared to control observations for media containing only the inhibitors. Tyramine 0-8 renin Rattus norvegicus 194-199 1155-4 1976 Tyramine-induced stimulation of renin release was blocked by the beta-blocking agent, propranolol (2 X 10(-4) M), and the neural uptake blocking agent, cocaine (10(-5) M), but not by the alpha-antagonist, phentolamine (9 X 10(-4) M). Tyramine 0-8 renin Rattus norvegicus 32-37 1155-4 1976 Tyramine-induced stimulation of renin release was blocked by the beta-blocking agent, propranolol (2 X 10(-4) M), and the neural uptake blocking agent, cocaine (10(-5) M), but not by the alpha-antagonist, phentolamine (9 X 10(-4) M). Propranolol 86-97 renin Rattus norvegicus 32-37 1155-4 1976 Tyramine-induced stimulation of renin release was blocked by the beta-blocking agent, propranolol (2 X 10(-4) M), and the neural uptake blocking agent, cocaine (10(-5) M), but not by the alpha-antagonist, phentolamine (9 X 10(-4) M). Cocaine 152-159 renin Rattus norvegicus 32-37 1253523-4 1976 Brief ether anesthesia was shown to produce a two- to three-fold increase in plasma renin activity in both strains. Ether 6-11 renin Rattus norvegicus 84-89 1022407-6 1976 The balance was restored by PGEI, which not only lowered blood pressure and decreased renal rein acitivity, but induced an increase of brain stem and medulla renin activity. pgei 28-32 renin Rattus norvegicus 158-163 172259-3 1976 The potentiation of vasoconstrictor responses to sympathetic nerve stimulation and injected norepinephrine which was elicited by renin substrate and angiotensin I was abolished by an inhibitor of angiotensin I-converting enzyme, SQ 20,881, and by an angiotensin II receptor antagonist, [Sar1-Ile8]angiotensin II. Norepinephrine 92-106 renin Rattus norvegicus 129-134 971551-9 1976 Release of renin was directly proportional to the number of glomeruli and could be stimulated by isoprenaline, adrenaline and noradrenaline in order of the potency of their action on beta-adrenoreceptors. Isoproterenol 97-109 renin Rattus norvegicus 11-16 971551-9 1976 Release of renin was directly proportional to the number of glomeruli and could be stimulated by isoprenaline, adrenaline and noradrenaline in order of the potency of their action on beta-adrenoreceptors. Epinephrine 111-121 renin Rattus norvegicus 11-16 971551-9 1976 Release of renin was directly proportional to the number of glomeruli and could be stimulated by isoprenaline, adrenaline and noradrenaline in order of the potency of their action on beta-adrenoreceptors. Norepinephrine 126-139 renin Rattus norvegicus 11-16 1022407-7 1976 It is concluded that there exists a notable connection between adrenal cortex regeneration, renal antihypertensive prostaglandins and the kidney and brain renin-angiotensin systems, which pays a correlated role in the mechanism of adrenal regeneration hypertension. Prostaglandins 115-129 renin Rattus norvegicus 155-160 985607-25 1976 SQ 20 881 inhibited the vasoconstrictor effects of AI and purified renin substrate, but did not influence the actions of TDP and the crude renin substrate preparation. sq 20 881 0-9 renin Rattus norvegicus 67-72 1246014-1 1976 Two-kidney renal hypertension in the rat (left renal artery narrowing) was shown to be dependent on the vasoconstrictor action of renin-angiotensin throughout its time course as evidenced by the simultaneous: 1) rise in blood pressure; 2) elevation in plasma renin activity; and 3) vasodepressor sensitivity to the converting enzyme inhibitor SQ-20881. Teprotide 343-351 renin Rattus norvegicus 130-135 1246014-6 1976 One-kidney renal artery-clipped animals that were only neonatally guanethidine-treated or were only adrenal-demedullated, also developed low-renin renal hypertension. Guanethidine 66-78 renin Rattus norvegicus 141-146 6958-1 1976 Propranolol administration in the hypoxic model of acute renal failure (ARF) in rats has reduced plasma renin activity (PRA) and uraemia as compared to untreated controls. Propranolol 0-11 renin Rattus norvegicus 104-109 2926-1 1976 The effects of centrally administered autonomic drugs and hypertonic saline on renin release were studied in the conscious rat. Sodium Chloride 69-75 renin Rattus norvegicus 79-84 2926-2 1976 A 0.3 mug intraventricular dose of isoproterenol, which is one-thirtieth of the intraperitoneal dose required to stimulate renin release, induced the release of renin into the systemic circulation. Isoproterenol 35-48 renin Rattus norvegicus 123-128 2926-2 1976 A 0.3 mug intraventricular dose of isoproterenol, which is one-thirtieth of the intraperitoneal dose required to stimulate renin release, induced the release of renin into the systemic circulation. Isoproterenol 35-48 renin Rattus norvegicus 161-166 1245784-3 1976 The DOCA and saline treatment was effective in reducing renal renin content to less than 10% of the normal values. Desoxycorticosterone Acetate 4-8 renin Rattus norvegicus 62-67 1245784-3 1976 The DOCA and saline treatment was effective in reducing renal renin content to less than 10% of the normal values. Sodium Chloride 13-19 renin Rattus norvegicus 62-67 1250856-0 1976 The effect of age and norepinephrine on renin release by rat kidney slices in vitro. Norepinephrine 22-36 renin Rattus norvegicus 40-45 1250856-4 1976 However, the ability of renin release to respond to stimuli, such as norepinephrine, is enhanced at the time of declining basal renin release and developing hypertension. Norepinephrine 69-83 renin Rattus norvegicus 24-29 6958-4 1976 These results support the view that beta-adrenergic blockade by propranolol reduces the severity of ARF by preventing the post-hypoxic release of renin. Propranolol 64-75 renin Rattus norvegicus 146-151 1250856-4 1976 However, the ability of renin release to respond to stimuli, such as norepinephrine, is enhanced at the time of declining basal renin release and developing hypertension. Norepinephrine 69-83 renin Rattus norvegicus 128-133 2926-4 1976 Hypertonic saline and carbachol suppressed renin release. Carbachol 22-31 renin Rattus norvegicus 43-48 1192571-3 1975 The plasma renin activity of normal and sodium-depleted rats was reduced after the administration of clonidine (100 mug/kg, iv) by 22.8% and 34.4%, respectively. Sodium 40-46 renin Rattus norvegicus 11-16 2926-6 1976 These results suggest a central nervous system site for sodium, beta-adrenergic, and cholinergic receptors in altering renin release and blood pressure. Sodium 56-62 renin Rattus norvegicus 119-124 1230143-1 1975 The effect of angiotensin I on renal perfusion pressure, and on basal and isoprenaline stimulated renin secretion, was examined in the isolated perfused rat kidney. Isoproterenol 74-86 renin Rattus norvegicus 98-103 1192571-3 1975 The plasma renin activity of normal and sodium-depleted rats was reduced after the administration of clonidine (100 mug/kg, iv) by 22.8% and 34.4%, respectively. Clonidine 101-110 renin Rattus norvegicus 11-16 1204291-0 1975 The stimulation of renin secretion by non-vasocontrictor infusions of adrenaline and noradrenaline in the isolated rat kidney. Epinephrine 70-80 renin Rattus norvegicus 19-24 1192571-8 1975 The data presented in this paper are consistent with the conclusion that clonidine acts at some site in the sympathetic nervous system of sodium-depleted rats to inhibit renal nerve activity with a resultant suppression of renin secretion and a reduction of the angiotensin II-maintained arterial blood pressure. Clonidine 73-82 renin Rattus norvegicus 223-228 1204291-0 1975 The stimulation of renin secretion by non-vasocontrictor infusions of adrenaline and noradrenaline in the isolated rat kidney. Norepinephrine 85-98 renin Rattus norvegicus 19-24 1204291-4 1975 Under these conditions adrenaline and noradrenaline significantly increased renin secretion rates, compared with control experiments in which no catecholamine was infused. Epinephrine 23-33 renin Rattus norvegicus 76-81 1192571-8 1975 The data presented in this paper are consistent with the conclusion that clonidine acts at some site in the sympathetic nervous system of sodium-depleted rats to inhibit renal nerve activity with a resultant suppression of renin secretion and a reduction of the angiotensin II-maintained arterial blood pressure. Sodium 138-144 renin Rattus norvegicus 223-228 1204291-4 1975 Under these conditions adrenaline and noradrenaline significantly increased renin secretion rates, compared with control experiments in which no catecholamine was infused. Norepinephrine 38-51 renin Rattus norvegicus 76-81 1204291-10 1975 These observations suggest that catecholamines stimulate renin secretion by an intrarenal effect which is largely independent of changes in renal perfusion pressure. Catecholamines 32-46 renin Rattus norvegicus 57-62 1195274-0 1975 Synthesis of lysophosphatidylethanolamine analogs that inhibit renin activity. lysophosphatidylethanolamine 13-41 renin Rattus norvegicus 63-68 1204570-0 1975 Sodium chloride suppression of renin release in the unanesthetized rat. Sodium Chloride 0-15 renin Rattus norvegicus 31-36 1204570-5 1975 Thus, in the absence of anesthesia, the renin-angiotensin-aldosterone system of the rat responds, as in other species, to a sodium load. Sodium 124-130 renin Rattus norvegicus 40-45 825378-0 1975 Plasma renin activity and renal sodium and water excretion following infusion of arachidonic acid in rats. Arachidonic Acid 81-97 renin Rattus norvegicus 7-12 825378-8 1975 Furthermore, these results suggest a complex interrelationship between PG-synthetase action, activation of the renal renin-angiotensin system and urinary water and sodium excretion. Water 154-159 renin Rattus norvegicus 117-122 1195274-2 1975 Arachidonyl- and linolenylphosphorylethanolamines (12, 13), arachidonyl (2-phthalimidoethyl)phosphonate (17), and arachidonyl (2-aminoethyl)phosphonate (18) were found to be effective inhibitors of the renin-renin substrate reaction in vitro; lysophosphatidylethanolamine analogs 14-16 of lesser unsaturation were either weakly active or inactive. arachidonyl- and linolenylphosphorylethanolamines 0-49 renin Rattus norvegicus 202-207 1195274-2 1975 Arachidonyl- and linolenylphosphorylethanolamines (12, 13), arachidonyl (2-phthalimidoethyl)phosphonate (17), and arachidonyl (2-aminoethyl)phosphonate (18) were found to be effective inhibitors of the renin-renin substrate reaction in vitro; lysophosphatidylethanolamine analogs 14-16 of lesser unsaturation were either weakly active or inactive. arachidonyl- and linolenylphosphorylethanolamines 0-49 renin Rattus norvegicus 208-213 1195274-2 1975 Arachidonyl- and linolenylphosphorylethanolamines (12, 13), arachidonyl (2-phthalimidoethyl)phosphonate (17), and arachidonyl (2-aminoethyl)phosphonate (18) were found to be effective inhibitors of the renin-renin substrate reaction in vitro; lysophosphatidylethanolamine analogs 14-16 of lesser unsaturation were either weakly active or inactive. arachidonyl (2-phthalimidoethyl)phosphonate 60-103 renin Rattus norvegicus 202-207 813373-7 1975 Both hypertensive MtT tumor-bearing animals and normotensive controls on a sodium deficient diet had a conspicuous increase of renal content of renin. Sodium 75-81 renin Rattus norvegicus 144-149 1195274-2 1975 Arachidonyl- and linolenylphosphorylethanolamines (12, 13), arachidonyl (2-phthalimidoethyl)phosphonate (17), and arachidonyl (2-aminoethyl)phosphonate (18) were found to be effective inhibitors of the renin-renin substrate reaction in vitro; lysophosphatidylethanolamine analogs 14-16 of lesser unsaturation were either weakly active or inactive. arachidonyl (2-phthalimidoethyl)phosphonate 60-103 renin Rattus norvegicus 208-213 1195274-3 1975 In a preliminary study, intramuscular administration of 25 mg/kg/day of arachidonyl (2-aminoethyl)phosphonate (18) to the hypertensive rat caused pronounced reduction (50 mm) in blood pressure within 3 days; upon continued dosage (15 mg/kg/day) of 18 for an additional 4 days, plasma renin activity was found to be 16 ng/0.1 ml/15 hr as compared with 69 ng/0.1 ml/15 hr before initial drug administration. arachidonyl (2-aminoethyl)phosphonate 72-109 renin Rattus norvegicus 284-289 1236608-6 1975 Increasing the dose of clonidine (3.4 nmol min-1 g-1) raised renal perfusion pressure, lowered perfusate flow rate and attenuated the response in renin secretion to isoprenaline. Isoproterenol 165-177 renin Rattus norvegicus 146-151 1236608-8 1975 Since the vasoconstrictor effect of clonidine is considered to be due to alpha-adrenergic stimulation, this observation is similar to a previous study reporting suppression of renin secretion by vasoconstrictor infusions of catecholamines (Vandongen & Peart, 1974). Clonidine 36-45 renin Rattus norvegicus 176-181 1236608-8 1975 Since the vasoconstrictor effect of clonidine is considered to be due to alpha-adrenergic stimulation, this observation is similar to a previous study reporting suppression of renin secretion by vasoconstrictor infusions of catecholamines (Vandongen & Peart, 1974). Catecholamines 224-238 renin Rattus norvegicus 176-181 1236608-0 1975 The inhibition of renin secretion in the isolated rat kidney by clonidine hydrochloride (Catapres). Clonidine 64-87 renin Rattus norvegicus 18-23 1236608-10 1975 These studies demonstrate a direct intrarenal inhibitory effect of clonidine on renin secretion. Clonidine 67-76 renin Rattus norvegicus 80-85 1236608-0 1975 The inhibition of renin secretion in the isolated rat kidney by clonidine hydrochloride (Catapres). Clonidine 89-97 renin Rattus norvegicus 18-23 1192618-4 1975 These observations indicate that, at a critically high BP level, it is salt and water loss which, by activating the renin-angiotensin system, trigger the vicious circle of malignant renal hypertension in rats. Salts 71-75 renin Rattus norvegicus 116-121 1206571-4 1975 by lowering sucrose concentration caused renin release rate to double. Sucrose 12-19 renin Rattus norvegicus 41-46 1192618-4 1975 These observations indicate that, at a critically high BP level, it is salt and water loss which, by activating the renin-angiotensin system, trigger the vicious circle of malignant renal hypertension in rats. Water 80-85 renin Rattus norvegicus 116-121 1236608-2 1975 The effect of clonidine HCl on basal and isoprenaline-stimulated renin secretion was examined in the isolated rat kidney. Clonidine 14-27 renin Rattus norvegicus 65-70 1236608-2 1975 The effect of clonidine HCl on basal and isoprenaline-stimulated renin secretion was examined in the isolated rat kidney. Isoproterenol 41-53 renin Rattus norvegicus 65-70 1236608-4 1975 Intrarenal infusion of clonidine at a dose level which did not increase renal perfusion pressure (1.9 nmol min-1 g-1), significantly lowered basal renin secretion without altering the stimulatory response to isoprenaline. Clonidine 23-32 renin Rattus norvegicus 147-152 1236608-6 1975 Increasing the dose of clonidine (3.4 nmol min-1 g-1) raised renal perfusion pressure, lowered perfusate flow rate and attenuated the response in renin secretion to isoprenaline. Clonidine 23-32 renin Rattus norvegicus 146-151 810901-1 1975 Plasma renin activity was found to be correlated positively with muscle water content and the presence of oedema in rats with protein energy malnutrition, whereas the muscle potassium content showed a negative correlation with muscle water content. Water 72-77 renin Rattus norvegicus 7-12 1208570-1 1975 Propranolol administration to rats was studied for its effects on plasma renin activity, renal renin content, and adrenal and brain isorenins. Propranolol 0-11 renin Rattus norvegicus 73-78 1208570-1 1975 Propranolol administration to rats was studied for its effects on plasma renin activity, renal renin content, and adrenal and brain isorenins. Propranolol 0-11 renin Rattus norvegicus 95-100 1208570-7 1975 These observations are consistent with those seen during chronic administration of propranolol to hypertensive patients and suggest that its antihypertensive effect may in some patients be through the suppression of renin release. Propranolol 83-94 renin Rattus norvegicus 216-221 810901-4 1975 It is therefore concluded that, although the inability to balance consumption and excretion of water may in part be the result of increased effective plasma renin activity, the increased plasma concentration results from increased secretion rather than from decreased inactivation. Water 95-100 renin Rattus norvegicus 157-162 1190925-4 1975 Plasma renin activity, as measured by radioimmunoassay, decreased below dehydrated control levels at one hour after glycerol administration (7.45 ng/ml/hr +/- 1.29 (SE) to 3.24 +/- 0.64), and progressively increased to a maximum 9.9 +/- 0.98) at 17 hours; there was no difference between dehydrated control levels and those obtained 24 and 48 hours after glycerol. Glycerol 116-124 renin Rattus norvegicus 7-12 1157220-1 1975 Controversy exists regarding the mechanism by which catecholamines stimulate renin secretion in vivo. Catecholamines 52-66 renin Rattus norvegicus 77-82 1190925-4 1975 Plasma renin activity, as measured by radioimmunoassay, decreased below dehydrated control levels at one hour after glycerol administration (7.45 ng/ml/hr +/- 1.29 (SE) to 3.24 +/- 0.64), and progressively increased to a maximum 9.9 +/- 0.98) at 17 hours; there was no difference between dehydrated control levels and those obtained 24 and 48 hours after glycerol. Glycerol 355-363 renin Rattus norvegicus 7-12 170788-8 1975 It is suggested that this increase is hardly due to an interception of the feedback, but to the concomitant fall in blood pressure, as a similar hypotension and increase in plasma renin is produced by dihydralazine. Dihydralazine 201-214 renin Rattus norvegicus 180-185 1157220-4 1975 Significant dose-related stimulation of renin release was observed with epinephrine and norepinephrine in concentrations from 1.5 times 10(-9) to 1.5 times 10(-7)M and with isoproterenol in concentrations from 2 times 10(-9) to 2 times 10(-7)M. No significant stimulation was seen with 10(-10)M concentrations of the three agents. Epinephrine 72-83 renin Rattus norvegicus 40-45 1157220-4 1975 Significant dose-related stimulation of renin release was observed with epinephrine and norepinephrine in concentrations from 1.5 times 10(-9) to 1.5 times 10(-7)M and with isoproterenol in concentrations from 2 times 10(-9) to 2 times 10(-7)M. No significant stimulation was seen with 10(-10)M concentrations of the three agents. Norepinephrine 88-102 renin Rattus norvegicus 40-45 1157220-4 1975 Significant dose-related stimulation of renin release was observed with epinephrine and norepinephrine in concentrations from 1.5 times 10(-9) to 1.5 times 10(-7)M and with isoproterenol in concentrations from 2 times 10(-9) to 2 times 10(-7)M. No significant stimulation was seen with 10(-10)M concentrations of the three agents. Isoproterenol 173-186 renin Rattus norvegicus 40-45 1157220-5 1975 Methoxamine (10(-6)M) stimulated renin release significantly (P less than 0.01). Methoxamine 0-11 renin Rattus norvegicus 33-38 1239731-3 1975 The renal vein renin concentration was 673 +/- 81 (SE) ng ml-1h-1 which was significantly higher than the concentration in the aorta of 456 +/- 50 (SE) ng ml-1h-1. Hydrogen 61-63 renin Rattus norvegicus 15-20 1159534-0 1975 Influence of vitamin B-6 on the renin--angiotensin system in rats. Vitamin B 6 13-24 renin Rattus norvegicus 32-37 1159534-2 1975 Both pyridoxine and 4-desoxypyridoxine caused a progressively increasing inhibition of the response to renin, which was totally suppressed after 24 days of treatment. Pyridoxine 5-15 renin Rattus norvegicus 103-108 1159534-2 1975 Both pyridoxine and 4-desoxypyridoxine caused a progressively increasing inhibition of the response to renin, which was totally suppressed after 24 days of treatment. 4-deoxypyridoxine 20-38 renin Rattus norvegicus 103-108 1159534-4 1975 The vitamin B-6-free diet caused an increase in basal blood pressure of 23 +/- 5 mmHg, over a period of 5 weeks, along with a simultaneous decrease in the response to renin and, though to a lesser degree, angiotensin II. Vitamin B 6 4-15 renin Rattus norvegicus 167-172 1239731-3 1975 The renal vein renin concentration was 673 +/- 81 (SE) ng ml-1h-1 which was significantly higher than the concentration in the aorta of 456 +/- 50 (SE) ng ml-1h-1. Hydrogen 158-160 renin Rattus norvegicus 15-20 1238994-10 1975 The sensitivity of kidney vasculature to adenosine parallelled high plasma renin activity (162 ng ang/ml-h in SR and 76 ng ang/ml-h in HR), elevated renal vascular resistance and low GFR. Adenosine 41-50 renin Rattus norvegicus 75-80 1175686-0 1975 The stimulation of renin secretion by diazoxide in the isolated rat kidney. Diazoxide 38-47 renin Rattus norvegicus 19-24 1175686-1 1975 The intrarenal effect of diazoxide on renin secretion was examined in the isolated perfused rat kidney. Diazoxide 25-34 renin Rattus norvegicus 38-43 1175686-2 1975 Mean renin secretion measured at 2 min intervals during the continuous infusion of diazoxide for 6 min was consistently higher than the corresponding control values, although this was significantly different at the end of the infusion only. Diazoxide 83-92 renin Rattus norvegicus 5-10 1175686-3 1975 Since renal perfusion pressure during diazoxide infusion and control studies decreased to a similar extent, it is suggested that diazoxide stimulates renin secretion by a direct effect on the juxtaglomerular cell. Diazoxide 129-138 renin Rattus norvegicus 150-155 1149397-6 1975 The exclusion of calcium ions from the perfusion medium abolished the vasoconstrictor effect of ADH and attenuated the inhibitory effect of ADH on isoprenaline-stimulated renin secretion. Calcium 17-24 renin Rattus norvegicus 171-176 1149397-6 1975 The exclusion of calcium ions from the perfusion medium abolished the vasoconstrictor effect of ADH and attenuated the inhibitory effect of ADH on isoprenaline-stimulated renin secretion. Isoproterenol 147-159 renin Rattus norvegicus 171-176 1149397-7 1975 However, significant suppression of renin secretion was still apparent compared with experiments where isoprenaline was infused alone. Isoproterenol 103-115 renin Rattus norvegicus 36-41 1149397-10 1975 Although this may be partly mediated by the rise in renal perfusion pressure, an additional direct effect of ADH on the renin-producing cell, which is dependent on the availability of calcium ions, is proposed. Calcium 184-191 renin Rattus norvegicus 120-125 1145199-3 1975 However, even after 15 weeks of hypertension, following sodium depletion by either diuretics or a low sodium diet, the animals again became renin dependent as readministration of the inhibitor induced a significant fall in blood pressure. Sodium 102-108 renin Rattus norvegicus 140-145 1180089-0 1975 Indomethacin blockade of renal PGE-synthesis: effect on total renal and tubular function and plasma renin concentration in hydropenic rats and on their response to isotonic saline. Indomethacin 0-12 renin Rattus norvegicus 100-105 167593-1 1975 Salt deprivation has been shown to cause fluid volume contraction and marked renin release; it is not clear whether angiotensin-induced vasoconstriction adds to low volume in compromising circulatory function or whether there are additional facets to the salt-deprived state. Salts 0-4 renin Rattus norvegicus 77-82 1149397-2 1975 The effect of antidiuretic hormone (ADH) on isoprenaline-stimulated renin secretion was examined in the isolated rat kidney perfused with modified Krebs-Ringer saline. Isoproterenol 44-56 renin Rattus norvegicus 68-73 1149397-4 1975 Intrarenal infusion OF ADH effectively prevented stimulation of renin secretion by isoprenaline whilst increasing renal perfusion pressure. Isoproterenol 83-95 renin Rattus norvegicus 64-69 1238994-12 1975 Our experiments demonstrated that a marked renal vasoconstriction caused by adenosine only occurs in rats in which renin-angiotensin system was stimulated. Adenosine 76-85 renin Rattus norvegicus 115-120 1077784-0 1975 Blockade of renin release by lanthanum. Lanthanum 29-38 renin Rattus norvegicus 12-17 1155613-3 1975 Increasing the medium sodium concentration (50-144 meq/liter) linearly decreased the rate of renin secretion. Sodium 22-28 renin Rattus norvegicus 93-98 1155613-5 1975 The addition of furosemide (from 10 minus 5 to 10 minus 3 M) stimulated renin secretion. Furosemide 16-26 renin Rattus norvegicus 72-77 1155613-6 1975 Considered with previous observations, these results suggest that renin secretionis controlled by some function of sodium on the lumenal boder of the macula densa cells. Sodium 115-121 renin Rattus norvegicus 66-71 1155615-2 1975 It is suggestedthat renal artery constriction activates the renin-angiotensin-aldosterone system, resulting in disordered regulation of salt and water balance and in blood pressure (BP) elevation. Salts 136-140 renin Rattus norvegicus 60-65 1155615-6 1975 It is assumed that pressure diuresis and natriuresis induce a vicious circle: the increasing renin activity may maintain or further increase BP level, therby inducing further salt and water loss, etc. Salts 175-179 renin Rattus norvegicus 93-98 1056277-4 1975 2. at 4 and 8 h after glycerol administration, plasma renin and angiotensin II had increased two to three-fold; they remained elevated for 48 h and then returned towards normal. Glycerol 22-30 renin Rattus norvegicus 54-59 1056277-7 1975 At 4 and 8 h after glycerol injection, kidney renin had decreased but it had increased after 24 and 48 h. 4. Glycerol 19-27 renin Rattus norvegicus 46-51 1077784-2 1975 The effects of lanthanum on renin release and renal vasoconstriction were studied in the isolated perfused rat kidney. Lanthanum 15-24 renin Rattus norvegicus 28-33 1077784-6 1975 Lanthanum prevented isoprenaline-induced and glucagon-induced stimulation of renin secretion. Lanthanum 0-9 renin Rattus norvegicus 77-82 1077784-6 1975 Lanthanum prevented isoprenaline-induced and glucagon-induced stimulation of renin secretion. Isoproterenol 20-32 renin Rattus norvegicus 77-82 1077784-6 1975 Lanthanum prevented isoprenaline-induced and glucagon-induced stimulation of renin secretion. Glucagon 45-53 renin Rattus norvegicus 77-82 1077786-8 1975 Intravenous infusion of inhibitor P-113, 5.5 nmol min-1 kg-1, into anaesthetized rats produced highly significant increases in PRA and plasma renin concentration without reduction in arterial pressure. Saralasin 34-39 renin Rattus norvegicus 142-147 166719-6 1975 Cyclic GMP and 8 Br-cyclic GMP caused a small rise in renin secretion in some experiments but this effect was independent of the dose and its physiological significance is uncertain. Cyclic GMP 0-10 renin Rattus norvegicus 54-59 166719-6 1975 Cyclic GMP and 8 Br-cyclic GMP caused a small rise in renin secretion in some experiments but this effect was independent of the dose and its physiological significance is uncertain. 8-bromocyclic GMP 15-30 renin Rattus norvegicus 54-59 166719-8 1975 Theophylline (10(-6) to 10(14) M) caused a significant elevation in renin secretion which was not blocked by (+)-propranolol. Theophylline 0-12 renin Rattus norvegicus 68-73 166719-11 1975 Despite previous suggestions that cyclic AMP stimulated renin secretion, this could not be confirmed in the present preparation. Cyclic AMP 34-44 renin Rattus norvegicus 56-61 234807-2 1975 Changes in sodium and potassium balance were related to changes in blood pressure, plasma renin activity, hematocrit, and kidney histology. Sodium 11-17 renin Rattus norvegicus 90-95 1122891-0 1975 Influence of adrenal enucleation of plasma renin substrate concentration in saline loaded and unilaterally nephroadrenalectomized rats. Sodium Chloride 76-82 renin Rattus norvegicus 43-48 168058-4 1975 Calcium also seemed to play an important role in the control of renin release from kidney slices. Calcium 0-7 renin Rattus norvegicus 64-69 168058-5 1975 However, the direct effects of sodium and potassium upon renin release were not conspicuous. Sodium 31-37 renin Rattus norvegicus 57-62 168058-5 1975 However, the direct effects of sodium and potassium upon renin release were not conspicuous. Potassium 42-51 renin Rattus norvegicus 57-62 1167223-10 1975 These results indicate that minoxidil-induced aldosterone release was mediated by the endogenous angiotensin II formed from renin release. Minoxidil 28-37 renin Rattus norvegicus 124-129 235222-3 1975 On normal diets, plasma renin concentration (PRC) of methylprednisolone-treated rats was significantly higher than that of DOC-treated rats. Methylprednisolone 53-71 renin Rattus norvegicus 24-29 235222-4 1975 Methylprednisolone treatment also resulted in a significant elevation of plasma renin substrate concentration (PRS). Methylprednisolone 0-18 renin Rattus norvegicus 80-85 235222-5 1975 Calculated plasma renin activity (PRA) was highest in methylprednisolone-treated rats, significantly above that of the DOC and no-steroid groups. Methylprednisolone 54-72 renin Rattus norvegicus 18-23 235222-5 1975 Calculated plasma renin activity (PRA) was highest in methylprednisolone-treated rats, significantly above that of the DOC and no-steroid groups. Steroids 130-137 renin Rattus norvegicus 18-23 1133791-2 1975 A method is described for studying renin release from superfused rat glomeruli following their rapid isolation by a magnetic iron-oxide technique. ferric oxide 125-135 renin Rattus norvegicus 35-40 1133791-27 1975 3 mM sodium cyanide plus 3 mM sodium iodoacetate caused a variable release of renin associated with depletion of content within 4 hr. Sodium Cyanide 5-19 renin Rattus norvegicus 78-83 1133791-27 1975 3 mM sodium cyanide plus 3 mM sodium iodoacetate caused a variable release of renin associated with depletion of content within 4 hr. Iodoacetic Acid 30-48 renin Rattus norvegicus 78-83 1133791-31 1975 This, together with the release observed with increased sodium concentration at constant osmolarity, suggests a dependence of renin release upon the mechanism controlling the volume of the juxtaglomerular cell or its organelles. Sodium 56-62 renin Rattus norvegicus 126-131 1167223-1 1975 The vasodilatory drugs, minoxidil and hydralazine, induce renin release in the rat, man and the dog. Minoxidil 24-33 renin Rattus norvegicus 58-63 1167223-1 1975 The vasodilatory drugs, minoxidil and hydralazine, induce renin release in the rat, man and the dog. Hydralazine 38-49 renin Rattus norvegicus 58-63 1167223-4 1975 Minoxidil and hydralazine induced a time-related increase in both serum renin activity and serum aldosterone. Minoxidil 0-9 renin Rattus norvegicus 72-77 1167223-4 1975 Minoxidil and hydralazine induced a time-related increase in both serum renin activity and serum aldosterone. Hydralazine 14-25 renin Rattus norvegicus 72-77 1167223-5 1975 Minoxidil caused a dose-related, proportional increase in serum renin and aldosterone. Minoxidil 0-9 renin Rattus norvegicus 64-69 1167223-7 1975 A competitive angiotensin antagonist, saralasin (1-Sar-8-Ala angiotensin II), impaired minoxidil-induced aldosterone release in a dose-related manner while potentiating minoxidil-induced renin release. Minoxidil 169-178 renin Rattus norvegicus 187-192 1167223-8 1975 Pretreatment with propranolol, a beta adrenergic blocking drug, impaired minoxidil-induced renin and aldosterone release. Propranolol 18-29 renin Rattus norvegicus 91-96 1167223-8 1975 Pretreatment with propranolol, a beta adrenergic blocking drug, impaired minoxidil-induced renin and aldosterone release. Minoxidil 73-82 renin Rattus norvegicus 91-96 234807-2 1975 Changes in sodium and potassium balance were related to changes in blood pressure, plasma renin activity, hematocrit, and kidney histology. Potassium 22-31 renin Rattus norvegicus 90-95 1119559-9 1975 A role for the sympathetic nervous system in the mediation of renin secretion by ether is proposed. Ether 81-86 renin Rattus norvegicus 62-67 234807-4 1975 Plasma renin activity remained markedly suppressed both at the fourth week (0.33 plus or minus 0.02 ng/ml hour-1) when the sodium balance was positive and the kidney biopsy negative and at the end of the experiment (0.35 plus or minus 0.36 ng/ml hour-1) when the sodium balance was negative and the kidney histology revealed malignant vasculitis. Sodium 123-129 renin Rattus norvegicus 7-12 234807-4 1975 Plasma renin activity remained markedly suppressed both at the fourth week (0.33 plus or minus 0.02 ng/ml hour-1) when the sodium balance was positive and the kidney biopsy negative and at the end of the experiment (0.35 plus or minus 0.36 ng/ml hour-1) when the sodium balance was negative and the kidney histology revealed malignant vasculitis. Sodium 263-269 renin Rattus norvegicus 7-12 1186925-0 1975 Suppression of isoprenaline-induced increase in plasma renin concentration by vasoconstrictors in rats with nonfunctioning Macula densa. Isoproterenol 15-27 renin Rattus norvegicus 55-60 1235227-0 1975 Effect of the protein-synthesis inhibitor actinomycin-D on the renin-angiotensin system in the rat. Dactinomycin 42-55 renin Rattus norvegicus 63-68 236325-2 1975 Propranolol can impair this renin release. Propranolol 0-11 renin Rattus norvegicus 28-33 236325-4 1975 In studies with normotensive rats, propranolol impaired renin release and tachycardia resulting from hydralazine and minoxidil and potentiated their hypotensive action. Propranolol 35-46 renin Rattus norvegicus 56-61 236325-10 1975 Propranolol was demonstrated to block hydralazine-induced increases in serum renin activity in genetically hypertensive rats. Propranolol 0-11 renin Rattus norvegicus 77-82 236325-10 1975 Propranolol was demonstrated to block hydralazine-induced increases in serum renin activity in genetically hypertensive rats. Hydralazine 38-49 renin Rattus norvegicus 77-82 236325-11 1975 We conclude that hypotensive potentiation of vasocilating drugs by propranolol in these animal models is mediated to a large extent by impairment of renin release. Propranolol 67-78 renin Rattus norvegicus 149-154 1167491-14 1975 The initial sodium retention could be a factor in the early rise of blood pressure and could account for the delay in the rise of peripheral plasma renin activity. Sodium 12-18 renin Rattus norvegicus 148-153 1167491-15 1975 The subsequent loss of the retained sodium and potassium during the development of severe hypertension could have facilitated the rise in peripheral plasma renin activity, but did not initiate this rise. Sodium 36-42 renin Rattus norvegicus 156-161 1167491-15 1975 The subsequent loss of the retained sodium and potassium during the development of severe hypertension could have facilitated the rise in peripheral plasma renin activity, but did not initiate this rise. Potassium 47-56 renin Rattus norvegicus 156-161 1153044-1 1975 Rats were kept for 4 weeks on a dietary regimen with a low or high sodium intake to increase or reduce, respectively, the renin activity of the kidneys and plasma. Sodium 67-73 renin Rattus norvegicus 122-127 1143449-0 1975 Proceedings: Acute and chronic effects of the aldosterone antagonist spironolactone and its main metabolite canrenone on plasma aldosterone concentration, plasma renin activity, serum electrolytes and on the excretion of aldosterone, fluid and electrolytes in rats. Spironolactone 69-83 renin Rattus norvegicus 162-167 1186925-1 1975 The mechanism of the increase in plasma renin concentration caused by the beta-sympathomimetic agent isoprenaline has been further investigated. Isoproterenol 101-113 renin Rattus norvegicus 40-45 1153045-1 1975 Renin secretion has been hypothesized to be inversely related to the tubular sodium concentration or load. Sodium 77-83 renin Rattus norvegicus 0-5 1153045-2 1975 Using rat kidney cortex slices, in vitro renin secretion was measured as a function of sodium concentration of the medium. Sodium 87-93 renin Rattus norvegicus 41-46 1153045-3 1975 We found, as have many others, that renin secretion increases with increasing medium sodium concentration. Sodium 85-91 renin Rattus norvegicus 36-41 1153045-4 1975 However, in the presence of 10(-3) M ouabain, renin secretion decreased with increasing medium sodium concentration. Sodium 95-101 renin Rattus norvegicus 46-51 1186925-3 1975 After contralateral nephrectomy infusion of isoprenaline (1.5 mug/kg min) still caused a strong increase in plasma renin concentration. Isoproterenol 44-56 renin Rattus norvegicus 115-120 812105-4 1975 NaCl 10% i.v., a more reduced renin-like activity was found both in hypophysis and epiphysis, that is 36.5 +/- 13 ng Ang/g/h and 144.5 +/- 38 Ang/g/h, respectively. Sodium Chloride 0-4 renin Rattus norvegicus 30-35 1186925-6 1975 The results exclude any mediator-role of the macula densa receptors in the isoprenaline-induced release of renin. Isoproterenol 75-87 renin Rattus norvegicus 107-112 4445170-0 1974 Effects of dietary sodium on renin content during renal hypertrophy in uninephrectomized rats. Sodium 19-25 renin Rattus norvegicus 29-34 4376436-5 1974 Both were significantly raised by SQ 20881.6 It is concluded that one of the mechanisms which mediate the dipsogenic effect of isoprenaline is stimulation of the renin-angiotensin system and that increased plasma levels of angiotensin I may play a substantial role in this type of drinking. Isoproterenol 127-139 renin Rattus norvegicus 162-167 4373493-2 1974 The intrarenal gradient of renin activity was determined in rats by using superficial (S) and deep (D) cortical juxtaglomerular apparatuses (JGA"s), identified and microdissected after silicone-rubber compound injection. Silicones 185-193 renin Rattus norvegicus 27-32 4373493-4 1974 When, in rats on a normal NaCl diet, silicone-rubber was injected into a carotid artery, alone or with abdominal aorta catheterization, S:D renin activity ratios were 1.18+/-0.08 (SEM) and 1.21+/-0.12, respectively. Silicones 37-45 renin Rattus norvegicus 140-145 4373493-5 1974 The S:D renin activity ratios obtained when silicone-rubber was injected into the abdominal aorta (2.52+/-0.09) or a chronic carotid artery catheter (3.44+/-0.40) were significantly higher (P < 0.001). Silicones 44-52 renin Rattus norvegicus 8-13 4373493-11 1974 These results demonstrate that NaCl intake clearly influences total JGA renin content and may also affect the relative intrarenal distribution of renin activity. Sodium Chloride 31-35 renin Rattus norvegicus 72-77 4373493-11 1974 These results demonstrate that NaCl intake clearly influences total JGA renin content and may also affect the relative intrarenal distribution of renin activity. Sodium Chloride 31-35 renin Rattus norvegicus 146-151 4370497-0 1974 The renin-angiotensin system and aldosterone secretion during sodium depletion in the rat. Sodium 62-68 renin Rattus norvegicus 4-9 4436432-0 1974 Effect of acute and chronic calcium administration on plasma renin. Calcium 28-35 renin Rattus norvegicus 61-66 4436432-12 1974 However, after 8 days of sodium deprivation, both PRA and renal renin content of calcium-loaded animals were significantly lower than the respective values in pair-fed controls (P < 0.005). Sodium 25-31 renin Rattus norvegicus 64-69 4436432-12 1974 However, after 8 days of sodium deprivation, both PRA and renal renin content of calcium-loaded animals were significantly lower than the respective values in pair-fed controls (P < 0.005). Calcium 81-88 renin Rattus norvegicus 64-69 4436432-14 1974 The data are consistent with the hypothesis that acute and chronic calcium administration inhibit renin secretion. Calcium 67-74 renin Rattus norvegicus 98-103 4809876-0 1974 Renin content in superficial and deep glomeruli of normal and salt-loaded rats. Salts 62-66 renin Rattus norvegicus 0-5 4476505-0 1974 [Proceedings: Changes in the renin level and the structure of the juxtaglomerular apparatus during reduction of salt intake, administration of diuretics and at the onset of nephrovascular hypertension in rats]. Salts 112-116 renin Rattus norvegicus 29-34 4370333-0 1974 Renin release by rat kidney slices in vitro: effects of cations and catecholamines. Catecholamines 68-82 renin Rattus norvegicus 0-5 4367716-0 1973 [Effect of metyrapone (SU 4885) on renin-angiotensin-aldosterone system of fasting rats]. Metyrapone 11-21 renin Rattus norvegicus 35-40 4367348-0 1974 Proceedings: Iso-renin in adrenal glands of rats: a possible factor in steroid production. Steroids 71-78 renin Rattus norvegicus 17-22 4470595-0 1974 Effects of folic acid on glucose-6-phosphate dehydrogenase and renin activities of the rat kidney. Folic Acid 11-21 renin Rattus norvegicus 63-68 4362948-0 1974 Calcium dependence of the inhibitory effect of angiotensin on renin secretion in the isolated perfused kidney of the rat. Calcium 0-7 renin Rattus norvegicus 62-67 4152366-0 1974 Proceedings: Effect of serotonin on water intake and renin-angiotensin system in rats. Serotonin 23-32 renin Rattus norvegicus 53-58 4367716-0 1973 [Effect of metyrapone (SU 4885) on renin-angiotensin-aldosterone system of fasting rats]. Metyrapone 23-30 renin Rattus norvegicus 35-40 4795631-0 1973 Effects of exogenous renin and sodium load on renin activity in unilaterally nephrectomized rats. Sodium 31-37 renin Rattus norvegicus 46-51 4359311-0 1973 Lysosomal enzyme activities in rat kidney treated with DOCA, especially with reference to renin, cathepsin and beta-glucuronidase. Desoxycorticosterone Acetate 55-59 renin Rattus norvegicus 90-95 4353877-0 1973 Elevated circulating renin activity in rats following doses of cadmium known to induce hypertension. Cadmium 63-70 renin Rattus norvegicus 21-26 4352088-6 1973 Renin-like activity in the rat submaxillary gland was increased after isoproterenol administration but not following pilocarpine.6. Isoproterenol 70-83 renin Rattus norvegicus 0-5 4352088-7 1973 Renin-like activity in the rat submaxillary gland was increased considerably by administration of NaCl or KCl, as well as following adrenalectomy.7. Sodium Chloride 98-102 renin Rattus norvegicus 0-5 4352088-7 1973 Renin-like activity in the rat submaxillary gland was increased considerably by administration of NaCl or KCl, as well as following adrenalectomy.7. Potassium Chloride 106-109 renin Rattus norvegicus 0-5 4352088-8 1973 Chlorothiazide and ouabain increased submaxillary renin-like activity but diazoxide did not affect this activity. Chlorothiazide 0-14 renin Rattus norvegicus 50-55 4352088-8 1973 Chlorothiazide and ouabain increased submaxillary renin-like activity but diazoxide did not affect this activity. Ouabain 19-26 renin Rattus norvegicus 50-55 4142233-0 1973 [Proceedings: Renin secretion and juxtaglomerular apparatus in folic-acid-induced kidney failure in the rat]. Folic Acid 63-73 renin Rattus norvegicus 14-19 5080704-5 1972 If the methylandrostenediol-treated animals were kept alive for 12 additional weeks after suspension of the treatment with the androgen, the hypertension, as well as the high sodium consumption, high plasma sodium concentrations and low levels of renal renin, persisted to the end of the experiment. Methandriol 7-27 renin Rattus norvegicus 253-258 4329425-0 1971 Renin suppression by DOC and NaCl in the rat. Desoxycorticosterone 21-24 renin Rattus norvegicus 0-5 4347297-0 1972 Effect of folic acid on plasma renin activity in rats. Folic Acid 10-20 renin Rattus norvegicus 31-36 4801914-0 1973 The transcellular fluid forming factor and renin in the kidney of hypertensive or salt-loaded rats. Salts 82-86 renin Rattus norvegicus 43-48 4334059-0 1972 Effect of mercuric chloride on plasma renin substrate level in rats. Mercuric Chloride 10-27 renin Rattus norvegicus 38-43 4336399-0 1971 [The effect of sodium chloride on the renin-angiotensin-aldosterone systems of rats of different ages and sex]. Sodium Chloride 15-30 renin Rattus norvegicus 38-43 4329425-0 1971 Renin suppression by DOC and NaCl in the rat. Sodium Chloride 29-33 renin Rattus norvegicus 0-5 4325461-9 1971 It is suggested that the actions of ovarian steroids on water and electrolyte metabolism might be due to increased activity of both the adrenal cortex and the renin-angiotensin system. Steroids 44-52 renin Rattus norvegicus 159-164 24179066-3 1971 This paper reviews evidence indicating that menstrual cycle psychopathology may be mediated by the effects of estrogen, progesterone, and possibly the renin-angiotensin-aldosterone system on the brain monoamines, norepinephrine, dopamine, and serotonin. monoamines 201-211 renin Rattus norvegicus 151-156 24179066-3 1971 This paper reviews evidence indicating that menstrual cycle psychopathology may be mediated by the effects of estrogen, progesterone, and possibly the renin-angiotensin-aldosterone system on the brain monoamines, norepinephrine, dopamine, and serotonin. Norepinephrine 213-227 renin Rattus norvegicus 151-156 24179066-3 1971 This paper reviews evidence indicating that menstrual cycle psychopathology may be mediated by the effects of estrogen, progesterone, and possibly the renin-angiotensin-aldosterone system on the brain monoamines, norepinephrine, dopamine, and serotonin. Dopamine 229-237 renin Rattus norvegicus 151-156 4943532-0 1971 [Effects of restriction, depletion and overload of sodium on plasma renin and juxta-glomerular index of the rat]. Sodium 51-57 renin Rattus norvegicus 68-73 5125544-0 1971 The influence of dietary sodium chloride on in vitro renin release from rat kidney slices. Sodium Chloride 25-40 renin Rattus norvegicus 53-58 24179066-3 1971 This paper reviews evidence indicating that menstrual cycle psychopathology may be mediated by the effects of estrogen, progesterone, and possibly the renin-angiotensin-aldosterone system on the brain monoamines, norepinephrine, dopamine, and serotonin. Serotonin 243-252 renin Rattus norvegicus 151-156 4325461-9 1971 It is suggested that the actions of ovarian steroids on water and electrolyte metabolism might be due to increased activity of both the adrenal cortex and the renin-angiotensin system. Water 56-61 renin Rattus norvegicus 159-164 4325462-5 1971 renin into the angiotensin-sensitive region causes the water-replete rat to drink. Water 55-60 renin Rattus norvegicus 0-5 4325462-7 1971 Synthetic tetradecapeptide renin substrate and angiotensin I were as effective as angiotensin II at causing water-replete rats to drink.4. Water 108-113 renin Rattus norvegicus 27-32 4319969-8 1970 Therefore, the effect seems to be mediated by a direct influence of potassium ions on renal renin secretion, perhaps via induced changes in sodium load to the macula densa.These studies point to an important role for potassium in the regulation of renin secretion. Sodium 140-146 renin Rattus norvegicus 248-253 4328534-0 1970 [Action of renal phospholipids on the renin-angiotensin system of the rat]. Phospholipids 17-30 renin Rattus norvegicus 38-43 5134293-0 1971 Effect of phenformin and chlorpropamide on renin activity in the rat. Phenformin 10-20 renin Rattus norvegicus 43-48 5134293-0 1971 Effect of phenformin and chlorpropamide on renin activity in the rat. Chlorpropamide 25-39 renin Rattus norvegicus 43-48 4319969-8 1970 Therefore, the effect seems to be mediated by a direct influence of potassium ions on renal renin secretion, perhaps via induced changes in sodium load to the macula densa.These studies point to an important role for potassium in the regulation of renin secretion. Potassium 217-226 renin Rattus norvegicus 92-97 4319969-3 1970 With less consistency, the highest sodium intake employed (52 mEq Na(+)/100 g food) tended to induce potassium depletion.In accordance with previous reports, sodium deprivation induced significant increases in plasma renin activity. Sodium 35-41 renin Rattus norvegicus 217-222 4319969-3 1970 With less consistency, the highest sodium intake employed (52 mEq Na(+)/100 g food) tended to induce potassium depletion.In accordance with previous reports, sodium deprivation induced significant increases in plasma renin activity. Potassium 101-110 renin Rattus norvegicus 217-222 4319969-8 1970 Therefore, the effect seems to be mediated by a direct influence of potassium ions on renal renin secretion, perhaps via induced changes in sodium load to the macula densa.These studies point to an important role for potassium in the regulation of renin secretion. Potassium 217-226 renin Rattus norvegicus 248-253 4319969-3 1970 With less consistency, the highest sodium intake employed (52 mEq Na(+)/100 g food) tended to induce potassium depletion.In accordance with previous reports, sodium deprivation induced significant increases in plasma renin activity. Sodium 158-164 renin Rattus norvegicus 217-222 4319969-5 1970 The results describe an inverse relationship between potassium administration and the concurrent level of plasma renin activity. Potassium 53-62 renin Rattus norvegicus 113-118 4319969-9 1970 The results in turn raise the possibility that renin secretion per se may be importantly involved in effecting potassium conservation and potassium elimination. Potassium 111-120 renin Rattus norvegicus 47-52 4319969-6 1970 The highest serum renin levels of all occurred in the potassium-depleted animals and the usual renin response to sodium deprivation was virtually abolished in the presence of a high potassium diet. Potassium 54-63 renin Rattus norvegicus 18-23 4319969-9 1970 The results in turn raise the possibility that renin secretion per se may be importantly involved in effecting potassium conservation and potassium elimination. Potassium 138-147 renin Rattus norvegicus 47-52 4319969-6 1970 The highest serum renin levels of all occurred in the potassium-depleted animals and the usual renin response to sodium deprivation was virtually abolished in the presence of a high potassium diet. Sodium 113-119 renin Rattus norvegicus 95-100 4319969-6 1970 The highest serum renin levels of all occurred in the potassium-depleted animals and the usual renin response to sodium deprivation was virtually abolished in the presence of a high potassium diet. Potassium 182-191 renin Rattus norvegicus 18-23 4100314-1 1970 The renin-system in normal, renal hypertensive and DOCA + salt treated rats after unilateral or bilateral nephrectomy or shamoperation. Desoxycorticosterone Acetate 51-55 renin Rattus norvegicus 4-9 4319969-6 1970 The highest serum renin levels of all occurred in the potassium-depleted animals and the usual renin response to sodium deprivation was virtually abolished in the presence of a high potassium diet. Potassium 182-191 renin Rattus norvegicus 95-100 4319969-8 1970 Therefore, the effect seems to be mediated by a direct influence of potassium ions on renal renin secretion, perhaps via induced changes in sodium load to the macula densa.These studies point to an important role for potassium in the regulation of renin secretion. Potassium 68-77 renin Rattus norvegicus 92-97 4319969-8 1970 Therefore, the effect seems to be mediated by a direct influence of potassium ions on renal renin secretion, perhaps via induced changes in sodium load to the macula densa.These studies point to an important role for potassium in the regulation of renin secretion. Potassium 68-77 renin Rattus norvegicus 248-253 5440311-0 1970 Influence of isoproterenol, hydralazine and phentolamine on the renin activity of plasma and renal cortex of rats. Isoproterenol 13-26 renin Rattus norvegicus 64-69 5440311-0 1970 Influence of isoproterenol, hydralazine and phentolamine on the renin activity of plasma and renal cortex of rats. Hydralazine 28-39 renin Rattus norvegicus 64-69 5440311-0 1970 Influence of isoproterenol, hydralazine and phentolamine on the renin activity of plasma and renal cortex of rats. Phentolamine 44-56 renin Rattus norvegicus 64-69 4312940-4 1970 High NaCl diet did not change the response of the R rats to these injections, but increased the response to renin and angiotensin in intact S rats. Sodium Chloride 5-9 renin Rattus norvegicus 108-113 4394344-0 1970 Increased plasma renin activity induced in rats by physostigmine and effects of alpha- and beta-receptors blocking drugs thereon. Physostigmine 51-64 renin Rattus norvegicus 17-22 4189856-0 1970 Influence of diethylstilbestrol on the renin-angiotensin system of male rats. Diethylstilbestrol 13-31 renin Rattus norvegicus 39-44 4322443-0 1970 The effect of the renin-angiotensin system on mucosal water and sodium transfer in everted sacs of rat jejunum. Sodium 64-70 renin Rattus norvegicus 18-23 4322443-9 1970 It is suggested that the renin-angiotensin system may be involved in the maintenance of sodium homoeostasis by a direct action on sodium transporting mechanisms. Sodium 88-94 renin Rattus norvegicus 25-30 4322443-9 1970 It is suggested that the renin-angiotensin system may be involved in the maintenance of sodium homoeostasis by a direct action on sodium transporting mechanisms. Sodium 130-136 renin Rattus norvegicus 25-30 4100314-1 1970 The renin-system in normal, renal hypertensive and DOCA + salt treated rats after unilateral or bilateral nephrectomy or shamoperation. Salts 58-62 renin Rattus norvegicus 4-9 5438898-0 1970 Micropuncture studies of the basis for protection of renin depleted rats from glycerol induced acute renal failure. Glycerol 78-86 renin Rattus norvegicus 53-58 4304486-0 1969 Pressor response to angiotensins I and II and renin in rats treated with carbon tetrachloride. Carbon Tetrachloride 73-93 renin Rattus norvegicus 46-51 4312627-0 1969 Augmentation of pressor response to renin and increased renin release in rats with mercuric chloride intoxication and with bilateral ureteral ligation. Mercuric Chloride 83-100 renin Rattus norvegicus 36-41 4312627-0 1969 Augmentation of pressor response to renin and increased renin release in rats with mercuric chloride intoxication and with bilateral ureteral ligation. Mercuric Chloride 83-100 renin Rattus norvegicus 56-61 5786734-0 1969 Absence of renin suppression by deoxycorticosterone acetate in rats. Desoxycorticosterone Acetate 32-59 renin Rattus norvegicus 11-16 5395843-2 1969 Influence of glucose on renin secretion. Glucose 13-20 renin Rattus norvegicus 24-29 5762532-0 1969 Release of renin by rat kidney slices; relationship to plasma renin after desoxycorticosterone and renal hypertension. Desoxycorticosterone 74-94 renin Rattus norvegicus 11-16 4242427-0 1969 [Effect of sodium depletion on experimental renal hypertension and renin activity in rats]. Sodium 11-17 renin Rattus norvegicus 67-72 5762532-0 1969 Release of renin by rat kidney slices; relationship to plasma renin after desoxycorticosterone and renal hypertension. Desoxycorticosterone 74-94 renin Rattus norvegicus 62-67 4297844-0 1967 [The effect of lithium chloride on the blood pressure actions of renin, angiotensin and noradrenaline in rats]. Lithium Chloride 15-31 renin Rattus norvegicus 65-70 4311371-0 1969 [Effect of 2,6-dichlorphenylamino-imidazoline-HCl on blood pressure and plasma renin activity in rats]. 2,6-dichlorphenylamino-imidazoline-hcl 11-49 renin Rattus norvegicus 79-84 5732199-0 1968 Renal juxtaglomerular cell granulation in acute and prolonged increase in renin production induced by hydralazine in the rat. Hydralazine 102-113 renin Rattus norvegicus 74-79 5231564-0 1967 Effect of hydralazine and pentolinium on renin release caused by bleeding in rats. Hydralazine 10-21 renin Rattus norvegicus 41-46 4289490-0 1967 Extraction and bioassay of renin from kidneys of sodium depleted and sodium-loaded rats. Sodium 49-55 renin Rattus norvegicus 27-32 4289490-0 1967 Extraction and bioassay of renin from kidneys of sodium depleted and sodium-loaded rats. Sodium 69-75 renin Rattus norvegicus 27-32 5231564-0 1967 Effect of hydralazine and pentolinium on renin release caused by bleeding in rats. Pentolinium Tartrate 26-37 renin Rattus norvegicus 41-46 13748680-0 1961 [Comparative studies on the effect of ADH, hypertensin and renin on the renal excretion of water and electrolytes in the rat]. Water 91-96 renin Rattus norvegicus 59-64 4298466-0 1967 [The effect of lithium chloride on the blood pressure action of renin, angiotensin and noradrenaline in rats]. Lithium Chloride 15-31 renin Rattus norvegicus 64-69 5326625-0 1966 [Action of actinomycin D and puromycin on the renal renin of the rat]. Dactinomycin 11-24 renin Rattus norvegicus 52-57 5326625-0 1966 [Action of actinomycin D and puromycin on the renal renin of the rat]. Puromycin 29-38 renin Rattus norvegicus 52-57 5602050-0 1967 Changes in renin content in kidneys of rats with experimental renal and NaCl hypertension. Sodium Chloride 72-76 renin Rattus norvegicus 11-16 14365708-0 1955 Effects of renin in rats treated with methylandrostenediol. Methandriol 38-58 renin Rattus norvegicus 11-16 13645748-0 1959 Increased renal pressor activity (renin) in sodium deficient rats and correlation with juxtaglomerular cell granulation. Sodium 44-50 renin Rattus norvegicus 34-39 13080271-0 1953 Effects of renin in rats pretreated with hydrocortisone and somatotrophin. Hydrocortisone 41-55 renin Rattus norvegicus 11-16 13172881-0 1954 Renin content of systemic blood of rats with desoxycorticosterone and metacorticoid hypertension. Desoxycorticosterone 45-65 renin Rattus norvegicus 0-5 13080271-0 1953 Effects of renin in rats pretreated with hydrocortisone and somatotrophin. somatotrophin 60-73 renin Rattus norvegicus 11-16 13092276-0 1953 Effect of renin on adrenal ascorbic acid concentration in rats. Ascorbic Acid 27-40 renin Rattus norvegicus 10-15 13057460-0 1953 Acute diffuse vascular disease elicited by renin in rats pretreated with cortisone. Cortisone 73-82 renin Rattus norvegicus 43-48 33415932-1 2020 INTRODUCTION: The high-fructose diet in rats has been reported to cause metabolic disorders such as impaired fasting glucose levels, in-sulin resistance, dyslipidemia, and dysregulation of the renin-angiotensin system. Fructose 23-31 renin Rattus norvegicus 193-198 14902225-0 1952 Renal and vascular lesions elicited by renin in rats with desoxycorticosterone hypertension. Desoxycorticosterone 58-78 renin Rattus norvegicus 39-44 34020248-4 2021 We determined mean arterial BP, heart rate, plasma arginine-vasopressin levels and renin activity in DOCA-salt rats orally treated with firibastat, enalapril or HCTZ administered alone or in combination. doca-salt 101-110 renin Rattus norvegicus 83-88 33185907-0 2021 Hesperidin inhibits L-NAME-induced vascular and renal alterations in rats by suppressing the renin-angiotensin system, transforming growth factor-beta1, and oxidative stress. Hesperidin 0-10 renin Rattus norvegicus 93-98 14885451-0 1951 Effects of renin on excretion of sodium, chloride and water in the rat. Sodium 33-39 renin Rattus norvegicus 11-16 14885451-0 1951 Effects of renin on excretion of sodium, chloride and water in the rat. Water 54-59 renin Rattus norvegicus 11-16 34020248-3 2021 In this study, we evaluated the efficacy of firibastat in combination with enalapril, an angiotensin I-converting enzyme inhibitor, and hydrochlorothiazide (HCTZ), in conscious hypertensive deoxycorticosterone acetate (DOCA)-salt rats, which display high plasma arginine-vasopressin levels, low circulating renin levels and resistance to treatment by systemic RAS blockers. firibastat 44-54 renin Rattus norvegicus 307-312 33586496-0 2021 Dietary Salt Modifies the Blood Pressure Response to Renin-Angiotensin Inhibition in Experimental Chronic Kidney Disease. Sodium Chloride, Dietary 0-12 renin Rattus norvegicus 53-58 33586496-9 2021 In summary, in the 5/6th nephrectomy rat CKD model, salt-sensitive hypertension develops with a selective increase in g-ENaC and despite appropriate transporter adaptations to low renin and hyperkalemia. Salts 52-56 renin Rattus norvegicus 180-185 33359638-0 2021 Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas. Ethylnitrosourea 111-128 renin Rattus norvegicus 31-36 33103451-2 2021 This study aimed to explore the respective effects of angiotensin II (ANG II) and angiotensin(1-7) [ANG(1-7)], active peptides in the renin-angiotensin system, on osteoblasts and osteoclasts under high-glucose level, as well as to investigate the osteo-preservative effects of ANG II type 1 receptor (AT1R) blocker and ANG(1-7) in diabetic spontaneously hypertensive rats (SHR). Peptides 118-126 renin Rattus norvegicus 134-139 33415932-8 2020 RESULTS: Our experiment showed that drinking 15% fructose solution induced dyslipidaemia accompanied by elevated lipid indexes as well as an increase in creatinine and renin plasma levels in the rats. Fructose 49-57 renin Rattus norvegicus 168-173 32631115-5 2020 PA (15 mg/kg) improves RAAS system (REN, ACE), inflammation (ET-1, IL-1beta) and MAPK pathway (p-ERK/ERK, p-JNK/JNK) better. 2-phenylacetamide 0-2 renin Rattus norvegicus 36-39 33053871-7 2020 Succinate, which is related to renin release, and betaine, which is related to lowering blood pressure, increased dose-dependently. Succinic Acid 0-9 renin Rattus norvegicus 31-36 32396454-0 2020 Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries. Losartan 37-45 renin Rattus norvegicus 0-5 33184370-1 2020 The renin-angiotensin system is known to regulate blood pressure as well as water- and electrolyte balance. Water 76-81 renin Rattus norvegicus 4-9 33184370-9 2020 However, whereas the protective effect of renin-b on caspase-mediated apoptosis was completely blocked by the renin inhibitor CH732, the effect on mitochondrial-mediated apoptosis was not affected by CH732 at all. ch732 126-131 renin Rattus norvegicus 42-47 32887022-15 2020 Oligosaccharides composition of Descurainiae sophia could significantly improve pathological damage of the heart, decrease the levels of cTnI, BNP, AngII, ALD, Renin, AVP in the serum, osmotic pressure and AQP2in the urine (P < 0.01 or P < 0.05), down-regulate the expression of AQP2 protein in the renal(P < 0.01), increase urine volume (P < 0.05). Oligosaccharides 0-16 renin Rattus norvegicus 160-165 33024842-15 2020 Conclusion: Our results indicate that repeated ITB in elderly rats is characterized by molecular modifications of cardiovascular key actors, particularly the Renin-angiotensin-aldosterone axis with a preserved physiological homeostasis. Aldosterone 176-187 renin Rattus norvegicus 158-163 32982180-2 2020 Aliskiren, as a direct renin inhibitor, has been shown to exert protective effects against arrhythmia. aliskiren 0-9 renin Rattus norvegicus 23-28 32742325-0 2020 Calcilytic NPS2143 promotes proliferation and inhibits apoptosis of spontaneously hypertensive rat vascular smooth muscle cells via activation of the renin-angiotensin system. N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine 11-18 renin Rattus norvegicus 150-155 32742325-2 2020 The activation of calcium-sensing receptor (CaSR), functionally expressed in VSMCs, inhibits cyclic adenosine monophosphate (cAMP) formation by elevating intracellular calcium ([Ca2+]i) and then suppressing renin release. Cyclic AMP 125-129 renin Rattus norvegicus 207-212 32742325-2 2020 The activation of calcium-sensing receptor (CaSR), functionally expressed in VSMCs, inhibits cyclic adenosine monophosphate (cAMP) formation by elevating intracellular calcium ([Ca2+]i) and then suppressing renin release. Calcium 18-25 renin Rattus norvegicus 207-212 32625100-0 2020 Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2. Potassium 8-17 renin Rattus norvegicus 65-70 32469228-10 2020 Suppression of corticosterone synthesis by PhADX increased basal plasma levels of ACTH, aldosterone and plasma renin activity in unstressed animals but there was no further increase of these hormones following stressor exposure. Corticosterone 15-29 renin Rattus norvegicus 111-116 32587126-9 2020 High fructose intake increased serum renin, Ang II, triglyceride, and cholesterol levels, but not Aldo levels. Fructose 5-13 renin Rattus norvegicus 37-42 32587126-10 2020 High fructose intake increased the expression of angiotensinogen in the liver; angiotensin-converting enzyme in the lungs; and renin, angiotensin II type 1a receptor (AT1aR), and angiotensin II type 1b receptor (AT1bR) in the kidneys. Fructose 5-13 renin Rattus norvegicus 127-132 32625100-4 2020 With the hypothesis that dietary potassium reduces renal vasoconstrictor components of the renin-angiotensin system in the long-term, we studied the effect of high potassium diet on angiotensin-I converting enzyme, renin, and angiotensin converting enzyme 2. Potassium 33-42 renin Rattus norvegicus 91-96 32625100-10 2020 Results: High potassium diet (4 weeks) reduced the levels of renin, angiotensin-I converting enzyme, and angiotensin converting enzyme 2. Potassium 14-23 renin Rattus norvegicus 61-66 32625100-13 2020 High potassium intake decreased angiotensin converting enzyme 2 gene expression and protein levels (P < 0.01).No morphological abnormalities were observed in renal tissue during high potassium diet.The reduced expression of angiotensin-I converting enzyme, renin, and angiotensin converting enzyme 2 during potassium supplementation suggest that high dietary potassium intake could modulate these vasoactive enzymes and this effects can contribute to the preventive and antihypertensive effect of potassium. Potassium 5-14 renin Rattus norvegicus 257-262 32179201-4 2020 Long-term sympathetic nerve excitability activates renin angiotensin aldosterone system leading to MF. Aldosterone 69-80 renin Rattus norvegicus 51-56 32356970-7 2020 Our study demonstrated that isorhynchophylline exhibited a strong anti-hypertensive effect in spontaneously hypertensive rats by improving the neurotransmitter imbalance in the hypothalamus and inhibiting the overactivation of renin-angiotensin system and sympathetic nerve system. rhyncophylline 28-46 renin Rattus norvegicus 227-232 31625581-2 2020 Renovascular hypertension represents the most common cause of secondary hypertension, and its progress is associated with overactivation of the renin angiotensin aldosterone system (RAAS), causing systemic and local changes. Angiotensins 150-161 renin Rattus norvegicus 144-149 31625581-2 2020 Renovascular hypertension represents the most common cause of secondary hypertension, and its progress is associated with overactivation of the renin angiotensin aldosterone system (RAAS), causing systemic and local changes. Aldosterone 162-173 renin Rattus norvegicus 144-149 31625581-3 2020 Aliskiren is a renin-inhibiting drug that optimizes RAAS suppression. aliskiren 0-9 renin Rattus norvegicus 15-20 31625581-6 2020 Our results showed that the hypertensive animals treated with Aliskiren presented a reestablishment of blood pressure, expression of renin, and renal function, as well as a remodeling of morphological alterations through the reduction of fibrosis. aliskiren 62-71 renin Rattus norvegicus 133-138 32054947-0 2020 Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning. Hydroxyl Radical 52-60 renin Rattus norvegicus 16-21 32174138-1 2020 Emerging evidence has demonstrated that (pro)renin receptor (PRR)-mediated activation of intrarenal renin-angiotensin system (RAS) plays an essential role in renal handling of Na+ and water balance and blood pressure. Water 184-189 renin Rattus norvegicus 45-50 32174138-7 2020 Administration of exogenous ELA-32 infusion (1.5 mg kg-1 day-1, minipump) to high salt (HS)-loaded Dahl salt-sensitive (SS) rats significantly lowered mean arterial pressure, systolic blood pressure, diastolic blood pressure, and albuminuria, accompanied with a reduction of urinary sPRR, angiotensin II, and prorenin/renin excretion. Elabela/Toddler-32 28-34 renin Rattus norvegicus 312-317 32174138-8 2020 HS upregulated renal medullary protein expression of fPRR, sPRR, prorenin, and renin in Dahl SS rats, all of which were significantly blunted by exogenous ELA-32 infusion. Elabela/Toddler-32 155-161 renin Rattus norvegicus 68-73 31705542-9 2020 CONCLUSION AND IMPLICATIONS: Losartan prevented the structural and functional indices of aortic stiffness in the iron loading rats, suggesting a capacity for renin-angiotensin system inhibition to limit the vascular remodeling in chronic iron overload. Iron 238-242 renin Rattus norvegicus 158-163 32208992-5 2020 C3a receptor antagonist SB290157 suppressed renin and LXRalpha expression, with inhibition of nuclear translocation of LXRalpha during the differentiation of mouse MSCs to SMCs. SB 290157 24-32 renin Rattus norvegicus 44-49 32240022-2 2020 Here we investigated AIH activation of the peripheral renin-angiotensin system (RAS) and the extent to which the magnitude of RAS activation predicts the magnitude of AIH-induced sLTF. CHEMBL182980 21-24 renin Rattus norvegicus 54-59 32054947-0 2020 Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning. Carbon Monoxide 107-122 renin Rattus norvegicus 16-21 32054947-10 2020 These findings suggest that the renin-angiotensin system might be involved in CO-induced OH production in a manner independent of cAMP signaling pathways. Carbon Monoxide 78-80 renin Rattus norvegicus 32-37 31884019-11 2020 In conclusion, our findings that both Ang II and aldosterone influence the activation of retinal microglia implicates the renin-angiotensin aldosterone system in the pathogenesis of ischemic retinopathies. Aldosterone 49-60 renin Rattus norvegicus 122-127 32118008-3 2020 Calcitriol is a negative endocrine regulator of the renin gene. Calcitriol 0-10 renin Rattus norvegicus 52-57 32047214-0 2020 Non-secretory renin reduces oxidative stress and increases cardiomyoblast survival during glucose and oxygen deprivation. Glucose 90-97 renin Rattus norvegicus 14-19 32047214-0 2020 Non-secretory renin reduces oxidative stress and increases cardiomyoblast survival during glucose and oxygen deprivation. Oxygen 102-108 renin Rattus norvegicus 14-19 32047214-3 2020 Here we tested the hypotheses that cytosolic renin [ren(2-9)] expression promotes cell survival under hypoxia and glucose depletion by preserving the mitochondrial membrane potential ( Psim) and mitigating the accumulation of ROS. Glucose 114-121 renin Rattus norvegicus 45-50 31884019-2 2020 We hypothesized that key effectors of the renin-angiotensin aldosterone system, angiotensin II (Ang II) and aldosterone, increase the density of microglia in the retina and stimulate their production of reactive oxygen species (ROS) as well as pro-angiogenic and pro-inflammatory factors. Aldosterone 60-71 renin Rattus norvegicus 42-47 31884019-11 2020 In conclusion, our findings that both Ang II and aldosterone influence the activation of retinal microglia implicates the renin-angiotensin aldosterone system in the pathogenesis of ischemic retinopathies. Aldosterone 140-151 renin Rattus norvegicus 122-127 31884019-2 2020 We hypothesized that key effectors of the renin-angiotensin aldosterone system, angiotensin II (Ang II) and aldosterone, increase the density of microglia in the retina and stimulate their production of reactive oxygen species (ROS) as well as pro-angiogenic and pro-inflammatory factors. Aldosterone 108-119 renin Rattus norvegicus 42-47 31654775-1 2020 Activation of renin-angiotensin- system, nitric oxide (NO ) bioavailability and subsequent sympathoexcitation plays a pivotal role in the pathogenesis of many cardiovascular diseases, including hypertension. Angiotensins 20-31 renin Rattus norvegicus 14-19 31884019-2 2020 We hypothesized that key effectors of the renin-angiotensin aldosterone system, angiotensin II (Ang II) and aldosterone, increase the density of microglia in the retina and stimulate their production of reactive oxygen species (ROS) as well as pro-angiogenic and pro-inflammatory factors. Reactive Oxygen Species 203-226 renin Rattus norvegicus 42-47 31884019-2 2020 We hypothesized that key effectors of the renin-angiotensin aldosterone system, angiotensin II (Ang II) and aldosterone, increase the density of microglia in the retina and stimulate their production of reactive oxygen species (ROS) as well as pro-angiogenic and pro-inflammatory factors. Reactive Oxygen Species 228-231 renin Rattus norvegicus 42-47 31923459-2 2020 Recently it was documented that renin-angiotensin system plays a key role in tissue inflammation, generation of reactive oxygen species (ROS) and tumor necrosis factor-alpha (TNF-alpha) (the principal liver injury mediators) during I/R. Oxygen 121-127 renin Rattus norvegicus 32-37 31759042-0 2020 Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting. tanshinone 0-14 renin Rattus norvegicus 68-73 31759042-10 2020 Moreover, Tanshinone IIA regulated the DRG renin angiotensin system (RAS) by reducing the protein expression of AGT, REN, ACE, ANGII and AT2 in DRG neurons. tanshinone 10-24 renin Rattus norvegicus 43-48 31759042-10 2020 Moreover, Tanshinone IIA regulated the DRG renin angiotensin system (RAS) by reducing the protein expression of AGT, REN, ACE, ANGII and AT2 in DRG neurons. tanshinone 10-24 renin Rattus norvegicus 117-120 31663146-11 2020 It has been proved that wheat bran has a good blood pressure lowering and antioxidation and other biological activities, and the <1 kDa fraction showing high oxygen radical absorbance capacity level also has better in vitro ACE inhibition and renin-inhibitory activity. Oxygen 158-164 renin Rattus norvegicus 243-248 31654775-1 2020 Activation of renin-angiotensin- system, nitric oxide (NO ) bioavailability and subsequent sympathoexcitation plays a pivotal role in the pathogenesis of many cardiovascular diseases, including hypertension. Nitric Oxide 41-53 renin Rattus norvegicus 14-19 31724456-0 2019 Perindopril mitigates LPS-induced cardiopulmonary oxidative and inflammatory damage via inhibition of renin angiotensin system, inflammation and oxidative stress. Perindopril 0-11 renin Rattus norvegicus 102-107 32305658-9 2020 And vancomycin (van) attenuated HFS-increased blood pressure (HFS: 121.3 +- 2.8 mm Hg; HFS-van: 111.1 +- 1.7 mm Hg) and heart rate (HFS: 360.5 +- 9.0 bpm; HFS-van: 318.7 +- 5.6 bpm) as well as the content of angiotensinogen, renin, and angiotensin II in the urine and the angiotensinogen mRNA level in renal cortical tissues. Vancomycin 4-14 renin Rattus norvegicus 225-230 32305658-9 2020 And vancomycin (van) attenuated HFS-increased blood pressure (HFS: 121.3 +- 2.8 mm Hg; HFS-van: 111.1 +- 1.7 mm Hg) and heart rate (HFS: 360.5 +- 9.0 bpm; HFS-van: 318.7 +- 5.6 bpm) as well as the content of angiotensinogen, renin, and angiotensin II in the urine and the angiotensinogen mRNA level in renal cortical tissues. Vancomycin 4-7 renin Rattus norvegicus 225-230 31566426-5 2019 Both diabetic groups had significantly altered renin-angiotensin-aldosterone system function. Aldosterone 53-76 renin Rattus norvegicus 47-52 31680980-0 2019 Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats. Potassium 0-9 renin Rattus norvegicus 47-52 31579950-0 2019 The effect of eplerenone on the renin-angiotensin-aldosterone system of rats with thyroid dysfunction. Aldosterone 38-61 renin Rattus norvegicus 32-37 31579950-8 2019 RESULTS: Eplerenone indicated a significant increase in renin and angiotensin I from 184.09 pg/ml and 178.66 pg/ml to 603.31 pg/ml and 250.88 pg/ml, respectively, meanwhile, aldosterone indicated no significant changes after inducing hypothyroidism and eplerenone administration. epl 9-19 renin Rattus norvegicus 56-61 31579950-11 2019 CONCLUSION: Eplerenone significantly increased the serum renin and angiotensin I in hypothyroid and aldosterone and angiotensin I in hyperthyroid rats. epl 12-22 renin Rattus norvegicus 57-62 31585137-0 2019 Evaluation of preclinical safety profile of SPH3127, a direct renin inhibitor, after 28-day repeated oral administration in Sprague-Dawley rats and cynomolgus monkeys. secophalloidin-H-A 44-51 renin Rattus norvegicus 62-67 31585137-1 2019 SPH3127, a newly developed oral nonpeptide direct renin inhibitor with good tolerance and favorable ADME (absorption distribution metabolism excretion) properties in preclinical species, is now being evaluated in phase Iota clinical trial. secophalloidin-H-A 0-7 renin Rattus norvegicus 50-55 31585137-4 2019 The adverse effects of SPH3127 on rats and monkeys mainly included kidney and cardiovascular toxicity, which were consistent with pharmacologic perturbations of physiologic processes associated with the intended molecular targets for this class of renin signaling inhibitors. secophalloidin-H-A 23-30 renin Rattus norvegicus 248-253 31216906-7 2019 Groups II, IV & VI showed a significant increase in creatinine, blood urea nitrogen, renal malondialdehyde, renal erythropoietin, plasma renin and plasma prostaglandin E2 and a significant decrease in renal antioxidants and serum vitamin D3. Adenosine Monophosphate 15-18 renin Rattus norvegicus 141-146 31096810-0 2019 Valsartan chronotherapy reverts the non-dipper pattern and improves blood pressure control through mediation of circadian rhythms of the renin-angiotensin system in spontaneous hypertension rats. Valsartan 0-9 renin Rattus norvegicus 137-142 31645725-2 2019 The receptor responsible for succinate signalling, SUCNR1 (also known as GPR91), is a member of the G-protein-coupled-receptor family2 and links succinate signalling to renin-induced hypertension, retinal angiogenesis and inflammation3-5. Succinates 29-38 renin Rattus norvegicus 169-174 31645725-2 2019 The receptor responsible for succinate signalling, SUCNR1 (also known as GPR91), is a member of the G-protein-coupled-receptor family2 and links succinate signalling to renin-induced hypertension, retinal angiogenesis and inflammation3-5. Succinates 145-154 renin Rattus norvegicus 169-174 31426337-1 2019 Vitamin D (Vit.D) is involved in cellular proliferation and differentiation and regulation of the renin gene, which are important aspects of nephrogenesis and quiescence of renal health in adulthood. Vitamin D 0-9 renin Rattus norvegicus 98-103 31378306-14 2019 Cox2-derived prostaglandins might play a role in brain-renin angiotensin system associated hypertension, and astrocytes could be significant players. Prostaglandins 13-27 renin Rattus norvegicus 55-60 31349653-1 2019 Aliskiren, a renin inhibitor, has been shown to have cardioprotective and blood pressure (BP) lowering effects. aliskiren 0-9 renin Rattus norvegicus 13-18 32154769-8 2019 Results revealed that both high and low sodium diet with low and high renin levels respectively block the influence of candesartan on CBF autoregulation. Sodium 40-46 renin Rattus norvegicus 70-75 31396276-0 2019 Aliskiren, Fosinopril, and Their Outcome on Renin-Angiotensin-Aldosterone System (RAAS) in Rats with Thyroid Dysfunction. aliskiren 0-9 renin Rattus norvegicus 44-49 31396276-3 2019 The current study was undertaken to find the impact of using a direct renin inhibitor (Aliskiren) and an angiotensin-converting enzyme inhibitor (Fosinopril) on the components of the renin-angiotensin-aldosterone system (RAAS) in rats with thyroid dysfunctions. Fosinopril 146-156 renin Rattus norvegicus 183-188 31396276-13 2019 Results: In hypothyroid induced rats, serum renin level dropped as expected, while the use of Aliskiren and Fosinopril on these hypothyroid rats raised renin level due to the feedback mechanism. aliskiren 94-103 renin Rattus norvegicus 152-157 31396276-13 2019 Results: In hypothyroid induced rats, serum renin level dropped as expected, while the use of Aliskiren and Fosinopril on these hypothyroid rats raised renin level due to the feedback mechanism. Fosinopril 108-118 renin Rattus norvegicus 152-157 31396276-19 2019 The use of Aliskiren and Fosinopril increased the level of renin nonsignificantly (decreased angiotensin I significantly). aliskiren 11-20 renin Rattus norvegicus 59-64 31396276-19 2019 The use of Aliskiren and Fosinopril increased the level of renin nonsignificantly (decreased angiotensin I significantly). Fosinopril 25-35 renin Rattus norvegicus 59-64 31517631-0 2019 Sex and salt intake dependent renin-angiotensin plasticity in the liver of the rat. Salts 8-12 renin Rattus norvegicus 30-35 32154769-8 2019 Results revealed that both high and low sodium diet with low and high renin levels respectively block the influence of candesartan on CBF autoregulation. candesartan 119-130 renin Rattus norvegicus 70-75 32154769-9 2019 This was expected in rats on a high salt diet with a low renin level, but unexpected in rats with a low salt intake with a high renin level. Salts 36-40 renin Rattus norvegicus 57-62 32154769-9 2019 This was expected in rats on a high salt diet with a low renin level, but unexpected in rats with a low salt intake with a high renin level. Salts 104-108 renin Rattus norvegicus 128-133 31053170-11 2019 Sacubitril-aliskiren or sacubitril-ramipril administration produced a significant increase in renin plasma level, total solute excretion, urine flow, and glomerular filtration rate. sacubitril and valsartan sodium hydrate drug combination 0-10 renin Rattus norvegicus 94-99 31030610-12 2019 Maximal blockade of the renin-angiotensin system, achieved by valsartan+siRNA, yielded the greatest reduction in blood pressure and cardiac hypertrophy, whereas AGT lowering alone was as effective as conventional renin-angiotensin system inhibitors. Valsartan 62-71 renin Rattus norvegicus 24-29 31116771-0 2019 Losartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands. Losartan 0-8 renin Rattus norvegicus 60-65 31116771-0 2019 Losartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands. Isoproterenol 13-26 renin Rattus norvegicus 60-65 31217731-0 2019 Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats. naringenin 0-10 renin Rattus norvegicus 92-97 31217731-12 2019 Conclusions: Naringenin attenuated renal damage in a rat model of renovascular hypertension by normalizing the imbalance of renin-angiotensin system activation. naringenin 13-23 renin Rattus norvegicus 124-129 31053170-11 2019 Sacubitril-aliskiren or sacubitril-ramipril administration produced a significant increase in renin plasma level, total solute excretion, urine flow, and glomerular filtration rate. sacubitril and valsartan sodium hydrate drug combination 24-34 renin Rattus norvegicus 94-99 31053170-11 2019 Sacubitril-aliskiren or sacubitril-ramipril administration produced a significant increase in renin plasma level, total solute excretion, urine flow, and glomerular filtration rate. Ramipril 35-43 renin Rattus norvegicus 94-99 30554341-2 2019 PGE2, the most abundant renal PG, plays a major role in renal physiology, including renin release and glomerular hemodynamics. Dinoprostone 0-4 renin Rattus norvegicus 84-89 29790816-1 2019 The pharmacokinetics of TAK-272 (SCO-272), an orally active renin inhibitor, was investigated in rats with subcutaneously injected turpentine oil, which was an inflammation animal model. imarikiren hydrochloride 24-31 renin Rattus norvegicus 60-65 29909753-0 2019 Alteration at transcriptional level of cardiac renin-angiotensin system by letrozole treatment. Letrozole 75-84 renin Rattus norvegicus 47-52 29909753-2 2019 Since accumulating evidence indicates that overactivation of the cardiac renin-angiotensin system (RAS) plays an important role in the development of cardiovascular diseases such as hypertrophy and remodelling, we aimed to investigate whether letrozole alters the transcription level of RAS related genes in the cardiac tissue. Letrozole 243-252 renin Rattus norvegicus 73-78 29909753-5 2019 RESULTS: The cardiac mRNA levels of several components of the RAS in the rats treated with letrozole were significantly increased including AT1a receptor (80%), renin (51%), and angiotensinogen (33%). Letrozole 91-100 renin Rattus norvegicus 161-166 30880253-11 2019 Furthermore, vildagliptin administration reduced both plasma renin activity and aldosterone concentrations in HSD rats. Vildagliptin 13-25 renin Rattus norvegicus 61-66 30554341-2 2019 PGE2, the most abundant renal PG, plays a major role in renal physiology, including renin release and glomerular hemodynamics. Prostaglandins 0-2 renin Rattus norvegicus 84-89 30790705-0 2019 Maternal high-sodium intake affects the offspring" vascular renin-angiotensin system promoting endothelial dysfunction in rats. Sodium 14-20 renin Rattus norvegicus 60-65 30110572-0 2018 Superoxide via Sp3 mechanism increases renal renin activity, renal AT1 receptor function, and blood pressure in rats. Superoxides 0-10 renin Rattus norvegicus 45-50 31468389-0 2019 Taurine Supplementation Inhibits Cardiac and Systemic Renin-Angiotensin System Overactivity After Cardiac Ischemia/Reperfusion in Adult Female Rats Perinatally Depleted of Taurine Followed by High Sugar Intake. Taurine 0-7 renin Rattus norvegicus 54-59 31468389-1 2019 Perinatal taurine depletion and high sugar intake from weaning onward worsen cardiac damage and arterial pressure control after ischemia/reperfusion (IR) in adult male and female rats, which can be ameliorated by high taurine diets or inhibition of renin-angiotensin system. Sugars 37-42 renin Rattus norvegicus 249-254 31468389-1 2019 Perinatal taurine depletion and high sugar intake from weaning onward worsen cardiac damage and arterial pressure control after ischemia/reperfusion (IR) in adult male and female rats, which can be ameliorated by high taurine diets or inhibition of renin-angiotensin system. Taurine 218-225 renin Rattus norvegicus 249-254 31468389-2 2019 This study tests if taurine supplementation ameliorates cardiac damage and arterial pressure control in adult female rats via alterations of both cardiac and systemic renin-angiotensin system. Taurine 20-27 renin Rattus norvegicus 167-172 31468389-9 2019 Thus, in adult female rats that are perinatally depleted of taurine followed by high sugar intake after weaning, taurine supplementation decreases the adverse effects of cardiac IR via inhibition of both cardiac and systemic renin-angiotensin system overactivity. Taurine 113-120 renin Rattus norvegicus 225-230 29308676-0 2018 Vitamin D protection from rat diabetic nephropathy is partly mediated through Klotho expression and renin-angiotensin inhibition. Vitamin D 0-9 renin Rattus norvegicus 100-105 29308676-4 2018 Vitamin D caused more reduction in monocyte chemoattractant protein-1 (MCP-1), transforming growth factor (TGFbeta-1), and renin-angiotensin levels that gave better kidney function compared to the DM + L group. Vitamin D 0-9 renin Rattus norvegicus 123-128 29308676-5 2018 CONCLUSION: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN. Vitamin D 12-21 renin Rattus norvegicus 149-154 29308676-5 2018 CONCLUSION: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN. Vitamin D 182-191 renin Rattus norvegicus 149-154 30247805-6 2018 Cardiac H9c2 cells overexpressing cyto-renin exhibited enhanced nonmitochondrial oxygen consumption, lactate accumulation, and LDH activity, reflecting a switch to more aerobic glycolysis known as Warburg effect. Oxygen 81-87 renin Rattus norvegicus 39-44 30247805-6 2018 Cardiac H9c2 cells overexpressing cyto-renin exhibited enhanced nonmitochondrial oxygen consumption, lactate accumulation, and LDH activity, reflecting a switch to more aerobic glycolysis known as Warburg effect. Lactic Acid 101-108 renin Rattus norvegicus 39-44 30379098-1 2019 The (pro)renin receptor (PRR) is a new component of the renin-angiotensin-aldosterone system (RAAS) and regulates renin activity. Aldosterone 74-85 renin Rattus norvegicus 9-14 29882088-11 2019 However, after spironolactone intervention, the expressions of ACE2, renin, AngII, Ang-(1-7), aldosterone and ICAM-1 in kidney tissue were changed, moreover, necrotic, inflammatory and fibrotic condition was also decreased. Spironolactone 15-29 renin Rattus norvegicus 69-74 30586551-0 2019 Nicousamide attenuates renal dysfunction and glomerular injury in remnant kidneys by inhibiting TGF-beta1 internalisation and renin activity. nicousamide 0-11 renin Rattus norvegicus 126-131 30586551-9 2019 In vitro studies suggested that nicousamide could moderately inhibit the renin activity and strongly block the TGF-beta1 internalisation into fibroblast cells. nicousamide 32-43 renin Rattus norvegicus 73-78 30586551-10 2019 In summary, nicousamide may protect from renal failure through dual targeting, which involves a TGF-beta1-dependent mechanism and inhibition of renin activity. nicousamide 12-23 renin Rattus norvegicus 144-149 30256128-0 2018 Involvement of complement 3 in the salt-sensitive hypertension by activation of renal renin-angiotensin system in spontaneously hypertensive rats. Salts 35-39 renin Rattus norvegicus 86-91 30382958-0 2018 Prenatal high-salt diet impaired vasodilatation with reprogrammed renin-angiotensin system in offspring rats. Salts 14-18 renin Rattus norvegicus 66-71 30382958-12 2018 CONCLUSION: The results suggest that prenatal high-salt diet impairs nitric oxide-mediated vasodilatation because of the increased oxidative stress-affected renin-angiotensin system in the high-salt offspring, providing new information for understanding, and early prevention of cardiovascular diseases in fetal origins. Salts 51-55 renin Rattus norvegicus 157-162 30382958-12 2018 CONCLUSION: The results suggest that prenatal high-salt diet impairs nitric oxide-mediated vasodilatation because of the increased oxidative stress-affected renin-angiotensin system in the high-salt offspring, providing new information for understanding, and early prevention of cardiovascular diseases in fetal origins. Nitric Oxide 69-81 renin Rattus norvegicus 157-162 30382958-12 2018 CONCLUSION: The results suggest that prenatal high-salt diet impairs nitric oxide-mediated vasodilatation because of the increased oxidative stress-affected renin-angiotensin system in the high-salt offspring, providing new information for understanding, and early prevention of cardiovascular diseases in fetal origins. Salts 194-198 renin Rattus norvegicus 157-162 30110572-1 2018 We tested a hypothesis that superoxide, by inducing Sp3, increases renal renin activity, renal angiotensin II type 1 receptor (AT1R) function, and blood pressure (BP) in rats. Superoxides 28-38 renin Rattus norvegicus 73-78 30110572-17 2018 Taken together, our results suggest that superoxide activates renal Sp3 via lysine acetylation increasing renin activity, AT1R function, and BP in rats. Superoxides 41-51 renin Rattus norvegicus 106-111 30110572-17 2018 Taken together, our results suggest that superoxide activates renal Sp3 via lysine acetylation increasing renin activity, AT1R function, and BP in rats. Lysine 76-82 renin Rattus norvegicus 106-111 30040952-0 2018 Nandrolone alter left ventricular contractility and promotes remodelling involving calcium-handling proteins and renin-angiotensin system in male SHR. Nandrolone 0-10 renin Rattus norvegicus 113-118 30231858-1 2018 BACKGROUND: Liver cirrhosis is characterized by avid sodium retention where the activation of the renin angiotensin aldosterone system (RAAS) is considered to be the hallmark of the sodium retaining mechanisms. Sodium 182-188 renin Rattus norvegicus 98-103 30231858-7 2018 At baseline the plasma renin concentration (PRC) was similar in sham and BDL animals, but increased urinary excretion of ANGII and an increase P-Aldosterone was observed in the placebo treated BDL animals. Phosphorus 44-45 renin Rattus norvegicus 23-28 30021383-6 2018 The anti-hypertensive effects of CMG are likely to be mediated by the decrease in renin serum levels. N(2)-carboxymethylguanosine 33-36 renin Rattus norvegicus 82-87 30021383-8 2018 We suggest a BP lowering effect of CMG via down-regulation of renin excretion associated with attenuation of target organ damage and inflammatory status. N(2)-carboxymethylguanosine 35-38 renin Rattus norvegicus 62-67 30638089-1 2018 PURPOSE: In a model of fat embolism using triolein-treated rats, we have reported that the acute pulmonary histopathological changes at 48 hrs were ameliorated by the angiotensin AT1 receptor blocker losartan, the angiotensin converting enzyme inhibitor captopril, and the direct renin inhibitor aliskiren. Losartan 200-208 renin Rattus norvegicus 280-285 30638089-13 2018 The fact that the protective effects of losartan treatment started at 6 weeks supports the involvement of the renin-angiotensin system in late as well as early stages of the histopathological changes following fat embolism. Losartan 40-48 renin Rattus norvegicus 110-115 30040952-15 2018 SIGNIFICANCE: Nandrolone has distinct effects on cardiac function and remodelling in male SHR, altering the hypertension development process in the heart through modulation of calcium handling proteins and the renin-angiotensin system. Nandrolone 14-24 renin Rattus norvegicus 210-215 30054426-3 2018 Malignant hypertension was induced in Cyp1a1-Ren-2 transgenic rats by activation of the renin gene using indole-3-carbinol (I3C), a natural xenobiotic. indole-3-carbinol 105-122 renin Rattus norvegicus 88-93 30054426-3 2018 Malignant hypertension was induced in Cyp1a1-Ren-2 transgenic rats by activation of the renin gene using indole-3-carbinol (I3C), a natural xenobiotic. indole-3-carbinol 124-127 renin Rattus norvegicus 88-93 30127255-9 2018 The beneficial effects of resveratrol on DEX + TCDD-induced hypertension relate to reduced renal mRNA expression of Ren, Ace, and Agtr1a expression. Resveratrol 26-37 renin Rattus norvegicus 116-119 30127255-9 2018 The beneficial effects of resveratrol on DEX + TCDD-induced hypertension relate to reduced renal mRNA expression of Ren, Ace, and Agtr1a expression. Dexamethasone 41-44 renin Rattus norvegicus 116-119 30127255-9 2018 The beneficial effects of resveratrol on DEX + TCDD-induced hypertension relate to reduced renal mRNA expression of Ren, Ace, and Agtr1a expression. Polychlorinated Dibenzodioxins 47-51 renin Rattus norvegicus 116-119 29945776-7 2018 The results of this present study demonstrated, for the first time, that short-term exposure to DEX treatment impairs the autonomic balance to the heart before hypertension, which was independent of renin-angiotensin system. Dexamethasone 96-99 renin Rattus norvegicus 199-204 29645283-14 2018 Repeated systemic injections of phenylephrine caused an elevation in SNA similar to AIH, and this effect was prevented by a renin inhibitor, aliskiren. Phenylephrine 32-45 renin Rattus norvegicus 124-129 29645283-14 2018 Repeated systemic injections of phenylephrine caused an elevation in SNA similar to AIH, and this effect was prevented by a renin inhibitor, aliskiren. aliskiren 141-150 renin Rattus norvegicus 124-129 29754833-0 2018 Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile. benzimidazole 13-26 renin Rattus norvegicus 56-61 30055626-0 2018 Resveratrol ameliorates maternal and post-weaning high-fat diet-induced nonalcoholic fatty liver disease via renin-angiotensin system. Resveratrol 0-11 renin Rattus norvegicus 109-114 30055626-7 2018 Resveratrol administration mediated a protective effect on rats on HF/HF by regulating lipid metabolism, reducing oxidative stress and apoptosis, restoring nutrient-sensing pathways by increasing Sirt1 and leptin expression, and mediating the renin-angiotensin system (RAS) to decrease angiotensinogen, renin, ACE1, and AT1R levels and increased ACE2, AT2R and MAS1 levels compared to those in the OHF group. Resveratrol 0-11 renin Rattus norvegicus 243-248 30055626-7 2018 Resveratrol administration mediated a protective effect on rats on HF/HF by regulating lipid metabolism, reducing oxidative stress and apoptosis, restoring nutrient-sensing pathways by increasing Sirt1 and leptin expression, and mediating the renin-angiotensin system (RAS) to decrease angiotensinogen, renin, ACE1, and AT1R levels and increased ACE2, AT2R and MAS1 levels compared to those in the OHF group. Resveratrol 0-11 renin Rattus norvegicus 303-308 29754833-0 2018 Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile. 3,5-disubstituted piperidine 90-118 renin Rattus norvegicus 56-61 29754833-3 2018 Conversion of the amino group attached at the 4-position of pyrimidine to methylene group improved PK profile and decreased renin inhibitory activity. pyrimidine 60-70 renin Rattus norvegicus 124-129 29754833-6 2018 In the course of modification, renin inhibitory activity was enhanced by the formation of an additional hydrogen bonding with the hydroxyl group of Thr77. Hydrogen 104-112 renin Rattus norvegicus 31-36 29754833-7 2018 Consequently, a series of novel benzimidazole derivatives were discovered as potent and orally bioavailable renin inhibitors. benzimidazole 32-45 renin Rattus norvegicus 108-113 29849862-3 2018 Recent studies have revealed that the renin-angiotensin system might play a role in kidney crystallization and ROS production. ros 111-114 renin Rattus norvegicus 38-43 29753230-7 2018 Similarly, nebivolol prevented ethanol-induced increase in plasma levels of renin, angiotensin I and II. Nebivolol 11-20 renin Rattus norvegicus 76-81 29753230-7 2018 Similarly, nebivolol prevented ethanol-induced increase in plasma levels of renin, angiotensin I and II. Ethanol 31-38 renin Rattus norvegicus 76-81 29753230-13 2018 Additionally, we showed that the sympathetic nervous system (SNS) and the renin-angiotensin system (RAS) are important endogenous mediators of the cardiovascular effects of ethanol. Ethanol 173-180 renin Rattus norvegicus 74-79 29521603-3 2018 Our objective was to determine genomic regions that physically interact with the renin proximal promoter, using two different genetic backgrounds, the Dahl salt sensitive and normotensive SS-13BN, which have been shown to have different regulation of plasma renin in vivo. dahl salt 151-160 renin Rattus norvegicus 81-86 29521603-3 2018 Our objective was to determine genomic regions that physically interact with the renin proximal promoter, using two different genetic backgrounds, the Dahl salt sensitive and normotensive SS-13BN, which have been shown to have different regulation of plasma renin in vivo. dahl salt 151-160 renin Rattus norvegicus 258-263 29849726-10 2018 In addition, western blot showed that the expression of alpha-SMA, TGF-beta, renin, and AT1 proteins was significantly decreased after receiving Qidan Dihuang decoction and losartan. Losartan 173-181 renin Rattus norvegicus 77-82 28977812-0 2018 Renin Inhibition by Aliskiren Protects Rats Against Isoproterenol Induced Myocardial Infarction. aliskiren 20-29 renin Rattus norvegicus 0-5 29540174-0 2018 Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin-angiotensin systems. Dexamethasone 9-22 renin Rattus norvegicus 170-175 29540174-7 2018 Prenatal DEX increased prorenin receptor and renin levels, but suppressed angiotensinogen (AGT) and angiotensin-converting-enzyme 1 (ACE1) mRNA expressions in adipose tissue. Dexamethasone 9-12 renin Rattus norvegicus 26-31 28977812-0 2018 Renin Inhibition by Aliskiren Protects Rats Against Isoproterenol Induced Myocardial Infarction. Isoproterenol 52-65 renin Rattus norvegicus 0-5 28985642-7 2018 Gene expression profiles performed on the aorta revealed that farrerol induced changes in vascular smooth muscle contraction, mitogen-activated protein kinase signaling pathway, regulation of actin cytoskeleton, vascular endothelial growth factor signaling pathway, calcium signaling pathway, and renin angiotensin system. farrerol 62-70 renin Rattus norvegicus 297-302 30308499-0 2018 Riligustilide Attenuated Renal Injury by the Blockade of Renin. riligustilide 0-13 renin Rattus norvegicus 57-62 28940861-9 2017 The renin-angiotensin system was enhanced in anaesthetized rats by prior manipulation of dietary sodium intake. Sodium 97-103 renin Rattus norvegicus 4-9 29172824-2 2018 Aliskiren is a newer agent that inhibits renin. aliskiren 0-9 renin Rattus norvegicus 41-46 28681939-6 2018 In addition, both vaccarin and captopril abrogated the increased plasma renin, angiotensin II (Ang II), norepinephrine (NE), and the basal sympathetic activity. vaccarin H 18-26 renin Rattus norvegicus 72-77 28681939-6 2018 In addition, both vaccarin and captopril abrogated the increased plasma renin, angiotensin II (Ang II), norepinephrine (NE), and the basal sympathetic activity. Captopril 31-40 renin Rattus norvegicus 72-77 29296095-3 2018 We hypothesized that at least part of the pathway leading to fructose-induced salt-sensitive hypertension could be due to fructose-induced formation of reactive oxygen species and inappropriate stimulation of renin secretion, all of which would contribute to an increase in blood pressure. Fructose 61-69 renin Rattus norvegicus 209-214 29296095-3 2018 We hypothesized that at least part of the pathway leading to fructose-induced salt-sensitive hypertension could be due to fructose-induced formation of reactive oxygen species and inappropriate stimulation of renin secretion, all of which would contribute to an increase in blood pressure. Salts 78-82 renin Rattus norvegicus 209-214 29296095-7 2018 A fructose plus high-salt diet induced a rapid increase (15 mmHg) in systolic blood pressure and reversed high salt suppression of plasma renin activity. Fructose 2-10 renin Rattus norvegicus 138-143 29296095-7 2018 A fructose plus high-salt diet induced a rapid increase (15 mmHg) in systolic blood pressure and reversed high salt suppression of plasma renin activity. Salts 21-25 renin Rattus norvegicus 138-143 29296095-8 2018 Tempol treatment reversed the pressor response and restored high salt suppression of renin. Salts 65-69 renin Rattus norvegicus 85-90 29296095-9 2018 We conclude that fructose-induced salt-sensitive hypertension is driven by increased renal reactive oxygen species formation associated with salt retention and an enhanced renin-angiotensin system. Fructose 17-25 renin Rattus norvegicus 172-177 29296095-9 2018 We conclude that fructose-induced salt-sensitive hypertension is driven by increased renal reactive oxygen species formation associated with salt retention and an enhanced renin-angiotensin system. Salts 34-38 renin Rattus norvegicus 172-177 29072501-8 2018 Next, sodium hydrosulfide administration reduces renal mRNA expression of Ren, Atp6ap2, Agt, Ace, and Agtr1a in SHRs. sodium bisulfide 6-25 renin Rattus norvegicus 74-77 28981205-7 2018 Additionally, d- or l-Cysteine supplementation reduce renal angiotensin I and angiotensin II concentrations, decrease mRNA expression of Ren, and increase protein levels of type 2 angiotensin II receptor. d- or l-cysteine 14-30 renin Rattus norvegicus 137-140 29220406-0 2017 Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats. Salts 16-20 renin Rattus norvegicus 80-85 29220406-0 2017 Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats. Salts 16-20 renin Rattus norvegicus 96-101 29220406-7 2017 The excessively low salt diet significantly elevated plasma renin activity, plasma angiotensin I, II and aldosterone concentrations, and plasma noradrenaline and adrenaline concentrations both in WKYs and SHRs. Salts 20-24 renin Rattus norvegicus 60-65 29220406-10 2017 CONCLUSION: An excessively low salt diet damages the heart through activation of plasma renin-angiotensin-aldosterone and sympatho-adrenal systems and activation of cardiac (P)RR and angiotensin II AT1 receptor and their downstream signals both in WKYs and SHRs. Salts 31-35 renin Rattus norvegicus 88-93 29066763-6 2017 UII increased by 7-fold the renal expression of renin in Group 2, increased aldosterone synthase expression in the adrenocortical zona glomerulosa, and prevented the blunting of renin expression induced by high salt. Salts 211-215 renin Rattus norvegicus 178-183 29078759-6 2017 Adenine diet did not influence kidney angiotensin converting enzyme (ACE) and AT4 receptor mRNA, but reduced mRNA of renin, AT1a, AT2, (pro)renin receptor and Mas to 40-60%, and suppressed ACE2 to 6% of that in controls. Adenine 0-7 renin Rattus norvegicus 117-122 29078759-11 2017 Sitaxentan and cinacalcet reduced kidney renin mRNA by 40%, while their combination alleviated tubulointerstitial damage and urinary calcium loss, and increased kidney tissue ACE2 mRNA. sitaxsentan 0-10 renin Rattus norvegicus 41-46 29078759-11 2017 Sitaxentan and cinacalcet reduced kidney renin mRNA by 40%, while their combination alleviated tubulointerstitial damage and urinary calcium loss, and increased kidney tissue ACE2 mRNA. Cinacalcet 15-25 renin Rattus norvegicus 41-46 29066763-8 2017 Moreover, it increases aldosterone synthase and counteracts the suppression of renin induced by salt loading. Salts 96-100 renin Rattus norvegicus 79-84 28696058-12 2017 Ceftazidime reduced Renin expression by 1.7-fold (p < 0.01). Ceftazidime 0-11 renin Rattus norvegicus 20-25 28904363-1 2017 Calcitriol has important effects on cellular differentiation and proliferation, as well as on the regulation of the renin gene. Calcitriol 0-10 renin Rattus norvegicus 116-121 28696058-13 2017 CONCLUSION: Our experiments showed that gentamicin at clinical levels did not disturb kidney development, ceftazidime can affect Renin expression, and extrauterine growth restriction impairs kidney development, but did not modulate potential drug toxicity. Ceftazidime 106-117 renin Rattus norvegicus 129-134 28509726-11 2017 In cultured innermedullary collecting duct cells, NaBu treatment attenuated Ang II-induced expression of PRR and renin. sethoxydim 50-54 renin Rattus norvegicus 113-118 28509726-12 2017 CONCLUSION: These results demonstrate that NaBu exerts an antihypertensive action, likely by suppressing the PRR-mediated intrarenal renin-angiotensin system. sethoxydim 43-47 renin Rattus norvegicus 133-138 28509726-0 2017 Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin-angiotensin system. Butyric Acid 0-15 renin Rattus norvegicus 91-96 28514645-0 2017 Oleanolic acid modulates the renin-angiotensin system and cardiac natriuretic hormone concomitantly with volume and pressure balance in rats. Oleanolic Acid 0-14 renin Rattus norvegicus 29-34 28509726-0 2017 Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin-angiotensin system. Butyric Acid 0-15 renin Rattus norvegicus 121-126 28514645-6 2017 Here, we found that oleanolic acid suppressed plasma levels of renin activity and aldosterone and intrarenal levels of renin and angiotensin II type 1 receptor expression and increased angiotensin II type 2 receptor in normotensive and hypertensive rats. Oleanolic Acid 20-34 renin Rattus norvegicus 63-68 28514645-10 2017 These findings suggest that beneficial effects of oleanolic acid on the cardiorenal system are closely associated with its roles on the renin-angiotensin system and cardiac natriuretic hormone system. Oleanolic Acid 50-64 renin Rattus norvegicus 136-141 28107310-0 2017 The renin inhibitor aliskiren protects rat lungs from the histopathologic effects of fat embolism. aliskiren 20-29 renin Rattus norvegicus 4-9 28700686-0 2017 Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats. Fructose 128-136 renin Rattus norvegicus 0-5 28700686-1 2017 Renin-angiotensin system in visceral fat plays a crucial role in the pathogenesis of metabolic syndrome in fructose-fed rats. Fructose 107-115 renin Rattus norvegicus 0-5 28700686-7 2017 Therefore, this study demonstrates renin inhibition could improve metabolic syndrome, and reduce Ang II levels and oxidative stress in visceral fat tissue in fructose-fed rats, and suggests that visceral adipose Ang II plays a crucial role in the pathogenesis of metabolic syndrome in fructose-fed rats. Fructose 158-166 renin Rattus norvegicus 35-40 28700686-7 2017 Therefore, this study demonstrates renin inhibition could improve metabolic syndrome, and reduce Ang II levels and oxidative stress in visceral fat tissue in fructose-fed rats, and suggests that visceral adipose Ang II plays a crucial role in the pathogenesis of metabolic syndrome in fructose-fed rats. Fructose 285-293 renin Rattus norvegicus 35-40 28690496-6 2017 However, aliskiren and enalapril could significantly decrease (p < 0.05) the levels of renin, Ang II and ALD in the blood, cerebral cortex, and hippocampus compared to DW treatment; while candesartan had similar effect on renin and ALD but no effect on Ang II in CCI rats. aliskiren 9-18 renin Rattus norvegicus 90-95 28690496-6 2017 However, aliskiren and enalapril could significantly decrease (p < 0.05) the levels of renin, Ang II and ALD in the blood, cerebral cortex, and hippocampus compared to DW treatment; while candesartan had similar effect on renin and ALD but no effect on Ang II in CCI rats. aliskiren 9-18 renin Rattus norvegicus 225-230 28690496-6 2017 However, aliskiren and enalapril could significantly decrease (p < 0.05) the levels of renin, Ang II and ALD in the blood, cerebral cortex, and hippocampus compared to DW treatment; while candesartan had similar effect on renin and ALD but no effect on Ang II in CCI rats. Enalapril 23-32 renin Rattus norvegicus 90-95 28690496-6 2017 However, aliskiren and enalapril could significantly decrease (p < 0.05) the levels of renin, Ang II and ALD in the blood, cerebral cortex, and hippocampus compared to DW treatment; while candesartan had similar effect on renin and ALD but no effect on Ang II in CCI rats. Enalapril 23-32 renin Rattus norvegicus 225-230 28690496-6 2017 However, aliskiren and enalapril could significantly decrease (p < 0.05) the levels of renin, Ang II and ALD in the blood, cerebral cortex, and hippocampus compared to DW treatment; while candesartan had similar effect on renin and ALD but no effect on Ang II in CCI rats. candesartan 191-202 renin Rattus norvegicus 225-230 28591164-2 2017 Angiotensin 1-7 and alamandine are heptameric renin angiotensin system peptide hormones. alamandine 20-30 renin Rattus norvegicus 46-51 28220244-5 2017 Renin, Ang III and dopamine concentrations decreased by ~25 to 50% and norepinephrine concentrations by 99% in DNX kidneys (p < 0.05) but were unaltered in opposite kidneys. fluorescent bezafibrate 111-114 renin Rattus norvegicus 0-5 28338001-0 2017 Renin-angiotensin system acting on reactive oxygen species in paraventricular nucleus induces sympathetic activation via AT1R/PKCgamma/Rac1 pathway in salt-induced hypertension. Reactive Oxygen Species 35-58 renin Rattus norvegicus 0-5 28338001-0 2017 Renin-angiotensin system acting on reactive oxygen species in paraventricular nucleus induces sympathetic activation via AT1R/PKCgamma/Rac1 pathway in salt-induced hypertension. Salts 151-155 renin Rattus norvegicus 0-5 28727756-0 2017 Dysregulation of microRNAs and renin-angiotensin system in high salt diet-induced cardiac dysfunction in uninephrectomized rats. Salts 64-68 renin Rattus norvegicus 31-36 28727756-3 2017 Hence in this study, we aimed to determine the effect of high salt diet on the alterations of renin-angiotensin system and microRNAs leading to CV and renal dysfunction in uninephrectomized rats. Salts 62-66 renin Rattus norvegicus 94-99 28274727-1 2017 BACKGROUND AND AIMS: In experimental investigations conducted in rats, raising serum uric acid (SUA) levels resulted in the stimulation of intrarenal renin expression. Uric Acid 85-94 renin Rattus norvegicus 150-155 28274727-1 2017 BACKGROUND AND AIMS: In experimental investigations conducted in rats, raising serum uric acid (SUA) levels resulted in the stimulation of intrarenal renin expression. sua 96-99 renin Rattus norvegicus 150-155 28003191-7 2017 Chronic CsA administration caused salt retention and hypertension, along with stimulation of renin and suppression of renal cyclooxygenase 2, pointing to a contribution of endocrine and paracrine mechanisms at long term. Cyclosporine 8-11 renin Rattus norvegicus 93-98 28107310-3 2017 We have shown in a rat model that the renin angiotensin system plays a significant role in the pathophysiology of FE because drugs interfering with the renin angiotensin system, captopril and losartan reduce the histopathologic pulmonary damage. Captopril 178-187 renin Rattus norvegicus 38-43 28107310-3 2017 We have shown in a rat model that the renin angiotensin system plays a significant role in the pathophysiology of FE because drugs interfering with the renin angiotensin system, captopril and losartan reduce the histopathologic pulmonary damage. Losartan 192-200 renin Rattus norvegicus 38-43 28107310-3 2017 We have shown in a rat model that the renin angiotensin system plays a significant role in the pathophysiology of FE because drugs interfering with the renin angiotensin system, captopril and losartan reduce the histopathologic pulmonary damage. Losartan 192-200 renin Rattus norvegicus 152-157 28107310-4 2017 The purpose of the current study was to determine if inhibition of renin by aliskiren, an FDA-approved drug for treating hypertension, would produce effective protection in the same model. aliskiren 76-85 renin Rattus norvegicus 67-72 28715805-6 2017 RESULTS: We identified a promoter in intron1 of the rat renin gene with two glucose starvation-sensitive regions. Glucose 76-83 renin Rattus norvegicus 56-61 28849441-1 2017 This study tests the hypothesis that taurine supplementation reduces sugar-induced increases in renal sympathetic nerve activity related to renin release in adult male rats. Taurine 37-44 renin Rattus norvegicus 140-145 28849441-1 2017 This study tests the hypothesis that taurine supplementation reduces sugar-induced increases in renal sympathetic nerve activity related to renin release in adult male rats. Sugars 69-74 renin Rattus norvegicus 140-145 28849441-9 2017 However, compared to CW group, CG significantly increased the power density of renin release-related frequency component, decreased that of sodium excretion-related frequency component, and decreased that of renal blood flow-related frequency component. cg 31-33 renin Rattus norvegicus 79-84 27629265-0 2017 Increased Dietary Salt Changes Baroreceptor Sensitivity and Intrarenal Renin-Angiotensin System in Goldblatt Hypertension. Salts 18-22 renin Rattus norvegicus 71-76 27629265-3 2017 AIM: The aim of this study was to evaluate whether a discrete increase in sodium chloride intake in 2K1C rats leads to changes in cardiovascular and autonomic function, oxidative stress, and renin angiotensin aldosterone system. Sodium Chloride 74-89 renin Rattus norvegicus 191-196 28101449-0 2017 Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet. Salts 122-126 renin Rattus norvegicus 45-50 28101449-5 2017 RESULTS: The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system (RAS). Sodium 28-34 renin Rattus norvegicus 138-143 28715805-9 2017 SRF knock down selectively decreased cytosolic renin expression and attenuated the increase of cytosolic renin expression under glucose depletion. Glucose 128-135 renin Rattus norvegicus 105-110 28715805-11 2017 The low basal expression of cytosolic renin as well as its induction under ischemia-related conditions represents an efficient system regulated in accordance with its previously identified unfavorable effects under control situations but protective effects seen after myocardial infarction or glucose depletion. Glucose 293-300 renin Rattus norvegicus 38-43 27784812-7 2017 In this regard, some of the injurious effects of vitamin D deficiency such as myocardial hypertrophy and high blood pressure seem linked to increased renin-angiotensin activity. Vitamin D 49-58 renin Rattus norvegicus 150-155 27457113-11 2016 Among them, genes belong to the renin-angiotensin system, and arachidonic acid metabolism pathways were potentially involved in the NG-nitro-L-arginine-methyl ester-induced programmed hypertension. Arachidonic Acid 62-78 renin Rattus norvegicus 32-37 27720848-16 2016 The plasma renin, Ang II and ACE activity were also significantly decreased and augmented the NO and cGMP levels. Cyclic GMP 101-105 renin Rattus norvegicus 11-16 27916218-2 2016 The present study was designed to evaluate the role of interaction of the renin-angiotensin system with 20-hydroxyeicosatetraenoic acid (20-HETE), a product of cytochrome P450 (CYP)-dependent omega-hydroxylase pathway, in the pathophysiology of angiotensin II (ANG II)-dependent malignant hypertension in Cyp1a1-Ren-2 transgenic rats. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 137-144 renin Rattus norvegicus 74-79 27916218-3 2016 METHODS: Malignant hypertension was induced by 12 days dietary administration of 0.3 % indole-3-carbinol (I3C), a natural xenobiotic that activates a mouse renin gene. indole-3-carbinol 88-105 renin Rattus norvegicus 157-162 27916218-8 2016 On the contrary, fenofibrate treatment significantly suppressed renin gene expression, plasma renin activity and plasma and kidney ANG II levels. Fenofibrate 17-28 renin Rattus norvegicus 64-69 27916218-8 2016 On the contrary, fenofibrate treatment significantly suppressed renin gene expression, plasma renin activity and plasma and kidney ANG II levels. Fenofibrate 17-28 renin Rattus norvegicus 94-99 27916218-9 2016 CONCLUSIONS: Fenofibrate treatment significantly attenuated the course of malignant hypertension in I3C-induced CYP1a1-Ren-2 transgenic rats, and the mechanism responsible for antihypertensive action was fenofibrate-induced suppression of renin-angiotensin system activity. Fenofibrate 13-24 renin Rattus norvegicus 239-244 27687967-0 2016 Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors. N-(piperidin-3-yl)pyrimidine-5-carboxamide 42-85 renin Rattus norvegicus 89-94 27687967-3 2016 New pyrimidine derivatives 5-14 were designed in an attempt to enhance the renin inhibitory activity of compound 3 identified by our previous fragment-based drug design approach. pyrimidine 4-14 renin Rattus norvegicus 75-80 27687967-4 2016 Introduction of a basic amine essential for interaction with the two aspartic acids in the catalytic site and optimization of the S1/S3 binding elements including an induced-fit structural change of Leu114 ("Leu-in" to "Leu-out") by a rational structure-based drug design approach led to the discovery of N-(piperidin-3-yl)pyrimidine-5-carboxamide 14, a 65,000-fold more potent renin inhibitor than compound 3. Amines 24-29 renin Rattus norvegicus 378-383 27687967-4 2016 Introduction of a basic amine essential for interaction with the two aspartic acids in the catalytic site and optimization of the S1/S3 binding elements including an induced-fit structural change of Leu114 ("Leu-in" to "Leu-out") by a rational structure-based drug design approach led to the discovery of N-(piperidin-3-yl)pyrimidine-5-carboxamide 14, a 65,000-fold more potent renin inhibitor than compound 3. Leucine 199-202 renin Rattus norvegicus 378-383 27916218-0 2016 Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats. Fenofibrate 0-11 renin Rattus norvegicus 68-73 27916218-2 2016 The present study was designed to evaluate the role of interaction of the renin-angiotensin system with 20-hydroxyeicosatetraenoic acid (20-HETE), a product of cytochrome P450 (CYP)-dependent omega-hydroxylase pathway, in the pathophysiology of angiotensin II (ANG II)-dependent malignant hypertension in Cyp1a1-Ren-2 transgenic rats. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 104-135 renin Rattus norvegicus 74-79 27457113-11 2016 Among them, genes belong to the renin-angiotensin system, and arachidonic acid metabolism pathways were potentially involved in the NG-nitro-L-arginine-methyl ester-induced programmed hypertension. NG-Nitroarginine Methyl Ester 132-164 renin Rattus norvegicus 32-37 27457113-12 2016 However, melatonin and N-acetylcysteine reprogrammed the renin-angiotensin system and arachidonic acid pathway differentially. Melatonin 9-18 renin Rattus norvegicus 57-62 27457113-12 2016 However, melatonin and N-acetylcysteine reprogrammed the renin-angiotensin system and arachidonic acid pathway differentially. Acetylcysteine 23-39 renin Rattus norvegicus 57-62 27753426-0 2016 Low-protein diet supplemented with ketoacids ameliorates proteinuria in 3/4 nephrectomised rats by directly inhibiting the intrarenal renin-angiotensin system. Keto Acids 35-44 renin Rattus norvegicus 134-139 27545826-0 2016 Intracellular renin increases the inward calcium current in smooth muscle cells of mesenteric artery of SHR. Calcium 41-48 renin Rattus norvegicus 14-19 27645307-0 2016 Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. aliskiren 61-70 renin Rattus norvegicus 11-16 27645307-0 2016 Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. Indomethacin 104-116 renin Rattus norvegicus 11-16 27645307-2 2016 Therefore, the aim of this study was to investigate the effects of aliskiren, and thus, direct renin blockage, in indomethacin-induced gastric damage model. aliskiren 67-76 renin Rattus norvegicus 95-100 27645307-2 2016 Therefore, the aim of this study was to investigate the effects of aliskiren, and thus, direct renin blockage, in indomethacin-induced gastric damage model. Indomethacin 114-126 renin Rattus norvegicus 95-100 27428043-2 2016 METHODS: Malignant hypertension was induced in Cyp1a1-Ren-2 transgenic rats by activation of the renin gene using indole-3-carbinol (I3C), a natural xenobiotic. indole-3-carbinol 114-131 renin Rattus norvegicus 97-102 27545826-2 2016 UNLABELLED: The influence of intracellular renin on the inward calcium current in isolated smooth muscle cells from SHR mesenteric arteries was investigated. Calcium 63-70 renin Rattus norvegicus 43-48 27774132-0 2016 Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor. imarikiren hydrochloride 13-20 renin Rattus norvegicus 57-62 27350190-0 2016 Water Deprivation Increases (Pro)renin Receptor Levels in the Kidney and Decreases Plasma Concentrations of Soluble (Pro)renin Receptor. Water 0-5 renin Rattus norvegicus 33-38 27385784-2 2016 We tested the hypothesis that prenatal testosterone exposure induces dysregulation of the renin-angiotensin-aldosterone system, which is known to play an important role in water and electrolyte balance and blood pressure regulation. Testosterone 39-51 renin Rattus norvegicus 90-95 27322834-1 2016 The present study investigated the possible renoprotective effect of direct renin inhibitor (aliskiren) on renal dysfunctions, as well as its underlying mechanisms in rat model of adenine-induced tubulointerstitial nephropathy. aliskiren 93-102 renin Rattus norvegicus 76-81 27322834-3 2016 It was found that adenine caused significant decrease in body mass, Hb, HR, serum Ca(2+), eNOS and nrf2 expression, GSH, and catalase in kidney tissues with significant increase in arterial blood pressure (ABP), serum creatinine, BUN, plasma renin activity (PRA), K(+) and P, urinary albumin excretion (UAE), caspase-3, and MDA (lipid peroxidation marker) in kidney tissues compared to normal group (p < 0.05). Adenine 18-25 renin Rattus norvegicus 242-247 27467376-7 2016 Compared to baseline, DOCA-salt treatment decreased plasma renin concentration (PRC), urinary renin excretion and medullary renin mRNA expression in both floxed and CD renin KO mice with no detectable differences between the two groups. Desoxycorticosterone Acetate 22-26 renin Rattus norvegicus 59-64 27467376-7 2016 Compared to baseline, DOCA-salt treatment decreased plasma renin concentration (PRC), urinary renin excretion and medullary renin mRNA expression in both floxed and CD renin KO mice with no detectable differences between the two groups. Desoxycorticosterone Acetate 22-26 renin Rattus norvegicus 94-99 27467376-7 2016 Compared to baseline, DOCA-salt treatment decreased plasma renin concentration (PRC), urinary renin excretion and medullary renin mRNA expression in both floxed and CD renin KO mice with no detectable differences between the two groups. Desoxycorticosterone Acetate 22-26 renin Rattus norvegicus 94-99 27467376-7 2016 Compared to baseline, DOCA-salt treatment decreased plasma renin concentration (PRC), urinary renin excretion and medullary renin mRNA expression in both floxed and CD renin KO mice with no detectable differences between the two groups. Desoxycorticosterone Acetate 22-26 renin Rattus norvegicus 94-99 27467376-7 2016 Compared to baseline, DOCA-salt treatment decreased plasma renin concentration (PRC), urinary renin excretion and medullary renin mRNA expression in both floxed and CD renin KO mice with no detectable differences between the two groups. Salts 27-31 renin Rattus norvegicus 59-64 27467376-7 2016 Compared to baseline, DOCA-salt treatment decreased plasma renin concentration (PRC), urinary renin excretion and medullary renin mRNA expression in both floxed and CD renin KO mice with no detectable differences between the two groups. Salts 27-31 renin Rattus norvegicus 94-99 27467376-7 2016 Compared to baseline, DOCA-salt treatment decreased plasma renin concentration (PRC), urinary renin excretion and medullary renin mRNA expression in both floxed and CD renin KO mice with no detectable differences between the two groups. Salts 27-31 renin Rattus norvegicus 94-99 27467376-7 2016 Compared to baseline, DOCA-salt treatment decreased plasma renin concentration (PRC), urinary renin excretion and medullary renin mRNA expression in both floxed and CD renin KO mice with no detectable differences between the two groups. Salts 27-31 renin Rattus norvegicus 94-99 27443990-0 2016 Renal sodium transport in renin-deficient Dahl salt-sensitive rats. Sodium 6-12 renin Rattus norvegicus 26-31 27443990-0 2016 Renal sodium transport in renin-deficient Dahl salt-sensitive rats. Salts 47-51 renin Rattus norvegicus 26-31 27443990-2 2016 The goal of this study was to assess the expression and activity of renal sodium channels and transporters in the renin-deficient salt-sensitive rat. Salts 130-134 renin Rattus norvegicus 114-119 26939623-1 2016 The aim of this study was to evaluate the effects of aliskiren, direct renin inhibitor, as an antioxidant and tissue protective agent and evaluate the molecular, biochemical, and histopathological changes in experimental ischemia and ischemia/reperfusion injury in rat ovaries. aliskiren 53-62 renin Rattus norvegicus 71-76 26939623-12 2016 This study concluded that aliskiren treatment is effective in reversing ischemia and/or ischemia/reperfusion induced ovary damage via the improvement of oxidative stress, reduction of inflammation, and suppression of the renin-angiotensin aldosterone system. aliskiren 26-35 renin Rattus norvegicus 221-226 27090360-6 2016 Renin content decreased in CD in the first eight h of reperfusion; however, after 16 h, its amount increased. Cadmium 27-29 renin Rattus norvegicus 0-5 27090360-8 2016 Renal ischemia/reperfusion injury induces renin response not only in the JGA, but also in the CD segment. Cadmium 94-96 renin Rattus norvegicus 42-47 27350190-0 2016 Water Deprivation Increases (Pro)renin Receptor Levels in the Kidney and Decreases Plasma Concentrations of Soluble (Pro)renin Receptor. Water 0-5 renin Rattus norvegicus 121-126 27350190-1 2016 Water deprivation activates the renin-angiotensin system. Water 0-5 renin Rattus norvegicus 32-37 26818798-0 2016 High maternal sodium intake alters sex-specific renal renin-angiotensin system components in newborn Wistar offspring. Sodium 14-20 renin Rattus norvegicus 54-59 26691308-0 2016 Vitamin D improves diabetic nephropathy in rats by inhibiting renin and relieving oxidative stress. Vitamin D 0-9 renin Rattus norvegicus 62-67 26691308-2 2016 Vitamin D may be important in maintaining podocyte health, preventing epithelial-to-mesenchymal transformation, and suppressing renin gene expression and inflammation, but its mechanism requires clarification. Vitamin D 0-9 renin Rattus norvegicus 128-133 26691308-8 2016 Vitamin D inhibited the compensatory increase in renin expression. Vitamin D 0-9 renin Rattus norvegicus 49-54 26691308-12 2016 CONCLUSIONS: Vitamin D combined with angiotensin II type 1 receptor blockers exerts a synergistic effect on the treatment of DN, not only by inhibiting renin but also by reducing oxidative stress and increasing the renal antioxidant capacity. Vitamin D 13-22 renin Rattus norvegicus 152-157 26928805-6 2016 It did cause parallel rises in urinary renin and albumin, which losartan but not hydralazine prevented. Losartan 64-72 renin Rattus norvegicus 39-44 27135968-13 2016 Neither blocker altered mammary carcinogenesis; analyses of losartan-treated animals indicated that expression of renin in the renal cortex and of Agtr1a (angiotensin II receptor, type 1) in cancer tissue was significantly upregulated, suggesting the presence of compensating mechanisms for blocking angiotensin-receptor signaling. Losartan 60-68 renin Rattus norvegicus 114-119 26866372-7 2016 Lisinopril alone caused a rebound activation of Renin-Angiotensin System (RAS), while MSC suppressed RENmRNA and Renin synthesis and induced a decrease of AII and aldosterone serum levels. Lisinopril 0-10 renin Rattus norvegicus 48-53 26920631-12 2016 SIGNIFICANCE: The anti-hypertensive effect of rutin may be a useful herbal medicine for the management of hypertension due to its potential free radical scavenging, inhibition of lipid peroxidation and plasma renin inhibitory action. Rutin 46-51 renin Rattus norvegicus 209-214 26280784-2 2016 Aliskiren directly inhibits renin which downregulates the renin-angiotensin-aldosterone system (RAAS). aliskiren 0-9 renin Rattus norvegicus 28-33 26280784-2 2016 Aliskiren directly inhibits renin which downregulates the renin-angiotensin-aldosterone system (RAAS). aliskiren 0-9 renin Rattus norvegicus 58-63 26280784-10 2016 Paracetamol toxicity increased alanine aminotransferases (ALT), aspartate aminotransferases (AST), renin, and angiotensin II levels in the serum samples. Acetaminophen 0-11 renin Rattus norvegicus 99-104 26476634-7 2016 Vinegar and acetic acid could decrease serum renin and angiotensin-converting enzyme (ACE) activities, angiotensin II and aldosterone concentrations in SHRs. Acetic Acid 12-23 renin Rattus norvegicus 45-50 27001276-3 2016 We hypothesized that RS could promote adiponectin secretion and regulate the renin-angiotensin system activity in the kidney. rs 21-23 renin Rattus norvegicus 77-82 27001276-10 2016 Taken together, we provide evidence that vitamin D balance in the presence of hyperglycemia is strongly associated with serum adiponectin levels and reduced renal renin-angiotensin system signaling. Vitamin D 41-50 renin Rattus norvegicus 163-168 26280784-14 2016 Only renin levels increased in aliskiren treatment groups due to its pharmacological effect. aliskiren 31-40 renin Rattus norvegicus 5-10 26121993-7 2016 The addition of clonidine 0.2 mug to diuretics (G2 vs. G7) reduced serum norepinephrine (169 +- 71 ng/L vs. 523 +- 88 ng/L) and plasma renin activity (12 +- 3 ng/ml/h vs. 25 +- 5 ng/ml/h) (all P < 0.05). Clonidine 16-25 renin Rattus norvegicus 135-140 27455575-2 2016 Preliminary inhibition of renin-angiotensin system (RAS) activity using ACE inhibitor enalapril (1 mg/kg, orally, 7 days) increases the sensitivity of rat kidney to drug, increasing its diuretic effect 2.33 times, natriuresis 2.49 times, and urine potassium excretion 1.80 times (p < 0.05). Enalapril 86-95 renin Rattus norvegicus 26-31 25023137-10 2016 Inhibitors of ACE and renin caused the elevation of the decreased of MMP and ATP levels. Adenosine Triphosphate 77-80 renin Rattus norvegicus 22-27 27455575-4 2016 Preliminary administration of direct renin inhibitor aliskiren (4 mg/kg, orally, 7 days) is accompanied by 2.30-fold increase in the diuretic effect of propranolol, 2.56-fold increase in natriuresis, and 2.27-fold increase in urine potassium excretion (p < 0.05). Potassium 232-241 renin Rattus norvegicus 37-42 27455575-2 2016 Preliminary inhibition of renin-angiotensin system (RAS) activity using ACE inhibitor enalapril (1 mg/kg, orally, 7 days) increases the sensitivity of rat kidney to drug, increasing its diuretic effect 2.33 times, natriuresis 2.49 times, and urine potassium excretion 1.80 times (p < 0.05). Potassium 248-257 renin Rattus norvegicus 26-31 27455575-4 2016 Preliminary administration of direct renin inhibitor aliskiren (4 mg/kg, orally, 7 days) is accompanied by 2.30-fold increase in the diuretic effect of propranolol, 2.56-fold increase in natriuresis, and 2.27-fold increase in urine potassium excretion (p < 0.05). aliskiren 53-62 renin Rattus norvegicus 37-42 27455575-4 2016 Preliminary administration of direct renin inhibitor aliskiren (4 mg/kg, orally, 7 days) is accompanied by 2.30-fold increase in the diuretic effect of propranolol, 2.56-fold increase in natriuresis, and 2.27-fold increase in urine potassium excretion (p < 0.05). Propranolol 152-163 renin Rattus norvegicus 37-42 26583047-9 2015 Additionally, the blocking of renin-angiotensin system through the down-regulation of ATR1 expression may also account for the reno-protective effect of progesterone. Progesterone 153-165 renin Rattus norvegicus 30-35 25981400-0 2016 Involvement of renin-angiotensin-aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury. Calcium Oxalate 55-70 renin Rattus norvegicus 15-20 25981400-13 2016 CONCLUSIONS: Results indicate that hyperoxaluria-induced production of ROS, injury and inflammation are in part associated with the activation of Nox through renin-angiotensin-aldosterone pathway. Reactive Oxygen Species 71-74 renin Rattus norvegicus 158-163 24737642-10 2015 CONCLUSION: These results suggest that aliskiren has protective effects against tacrolimus-induced nephrotoxicity; implying that renin inhibitor may counteract nephrotic syndrome associated with immunosuppressant use. aliskiren 39-48 renin Rattus norvegicus 129-134 24737642-10 2015 CONCLUSION: These results suggest that aliskiren has protective effects against tacrolimus-induced nephrotoxicity; implying that renin inhibitor may counteract nephrotic syndrome associated with immunosuppressant use. Tacrolimus 80-90 renin Rattus norvegicus 129-134 26268270-0 2015 PKC-alpha-dependent augmentation of cAMP and CREB phosphorylation mediates the angiotensin II stimulation of renin in the collecting duct. Cyclic AMP 36-40 renin Rattus norvegicus 109-114 26268270-3 2015 We hypothesize that ANG II stimulates CD renin synthesis through AT1R via PKC and the subsequent activation of cAMP/PKA/CREB pathway. Cyclic AMP 111-115 renin Rattus norvegicus 41-46 26268270-6 2015 Forskolin-induced increases in cAMP and renin expression were prevented by calphostin C. PKC inhibition and Ca2+ depletion impaired ANG II-mediated CREB phosphorylation and upregulation of renin. Colforsin 0-9 renin Rattus norvegicus 40-45 26268270-6 2015 Forskolin-induced increases in cAMP and renin expression were prevented by calphostin C. PKC inhibition and Ca2+ depletion impaired ANG II-mediated CREB phosphorylation and upregulation of renin. Colforsin 0-9 renin Rattus norvegicus 189-194 26268270-6 2015 Forskolin-induced increases in cAMP and renin expression were prevented by calphostin C. PKC inhibition and Ca2+ depletion impaired ANG II-mediated CREB phosphorylation and upregulation of renin. Cyclic AMP 31-35 renin Rattus norvegicus 189-194 26268270-9 2015 The results suggest that the ANG II-dependent upregulation of renin in the CD depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB pathway via AC6. Cadmium 75-77 renin Rattus norvegicus 62-67 26268270-9 2015 The results suggest that the ANG II-dependent upregulation of renin in the CD depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB pathway via AC6. Cyclic AMP 133-137 renin Rattus norvegicus 62-67 26268270-10 2015 This study defines the intracellular signaling pathway involved in the ANG II-mediated stimulation of renin in the CD. Cadmium 115-117 renin Rattus norvegicus 102-107 26256830-6 2016 Overexpression of cytosolic renin reduced the rate of necrosis in H9c2 cardiomyoblasts and in primary cardiomyocytes after glucose depletion. Glucose 123-130 renin Rattus norvegicus 28-33 26256830-8 2016 siRNA-mediated knockdown of endogenous cytosolic renin increased the rate of necrosis and aggravated the pro-necrotic effects of glucose depletion. Glucose 129-136 renin Rattus norvegicus 49-54 26256830-10 2016 Cytosolic renin is essential for survival, both under basal conditions and during glucose starvation. Glucose 82-89 renin Rattus norvegicus 10-15 26297928-12 2015 Following isoleucine-tryptophan and captopril treatments, gene expression of renin was significantly increased indicating an active feedback within renin-angiotensin system. isoleucine-tryptophan 10-31 renin Rattus norvegicus 77-82 26297928-12 2015 Following isoleucine-tryptophan and captopril treatments, gene expression of renin was significantly increased indicating an active feedback within renin-angiotensin system. isoleucine-tryptophan 10-31 renin Rattus norvegicus 148-153 26297928-12 2015 Following isoleucine-tryptophan and captopril treatments, gene expression of renin was significantly increased indicating an active feedback within renin-angiotensin system. Captopril 36-45 renin Rattus norvegicus 77-82 26297928-12 2015 Following isoleucine-tryptophan and captopril treatments, gene expression of renin was significantly increased indicating an active feedback within renin-angiotensin system. Captopril 36-45 renin Rattus norvegicus 148-153 26298003-6 2015 Systemic administration of acetaldehyde with cyanamide suppressed blood pressure and increased plasma renin activity. Acetaldehyde 27-39 renin Rattus norvegicus 102-107 26298003-6 2015 Systemic administration of acetaldehyde with cyanamide suppressed blood pressure and increased plasma renin activity. Cyanamide 45-54 renin Rattus norvegicus 102-107 26298003-11 2015 First acetaldehyde indirectly activates AT1R in the dipsogenic centers via the peripheral renin-angiotensin system following the depressor response and induces both water and salt intake. Acetaldehyde 6-18 renin Rattus norvegicus 90-95 25715999-8 2015 TRAM-34 also reduced the increase of renin and angiotensinogen in the plasma and myocardium of pressure-overloaded rats. TRAM 34 0-7 renin Rattus norvegicus 37-42 26238503-0 2015 Yiqi Huaju formula, a Chinese herbal medicine, reduces arterial pressure in salt-sensitive hypertension by inhibiting renin-angiotensin system activation. Salts 76-80 renin Rattus norvegicus 118-123 25872164-1 2015 OBJECTIVES: We hypothesized that chronic ethanol intake enhances vascular oxidative stress and induces hypertension through renin-angiotensin system (RAS) activation. Ethanol 41-48 renin Rattus norvegicus 124-129 25872164-5 2015 Chronic ethanol intake increased plasma renin activity (PRA), angiotensin converting enzyme (ACE) activity, plasma angiotensin I (ANG I) and angiotensin II (ANG II) levels and serum aldosterone levels. Ethanol 8-15 renin Rattus norvegicus 40-45 25770092-1 2015 BACKGROUND: The kidney, via its regulation of sodium excretion, which is modulated by humoral factors, including the dopamine and renin-angiotensin systems, keeps the blood pressure in the normal range. Sodium 46-52 renin Rattus norvegicus 130-135 26120029-7 2015 The results suggest that water and sodium ingestion in response to hypovolemic/hypotensive stimuli are disturbed in nephrotic rats, and provide evidence that the disordered behaviors reflect disturbances of the peripheral renin-angiotensin-aldosterone system. Water 25-30 renin Rattus norvegicus 222-227 26120029-7 2015 The results suggest that water and sodium ingestion in response to hypovolemic/hypotensive stimuli are disturbed in nephrotic rats, and provide evidence that the disordered behaviors reflect disturbances of the peripheral renin-angiotensin-aldosterone system. Sodium 35-41 renin Rattus norvegicus 222-227 26162424-2 2015 In this report, we re-examine our prior work on the effects of a metabolic acidosis on urinary oxalate handling [Green et al., Am J Physiol Ren Physiol 289(3):F536-F543, 2005], offering a more detailed analysis and interpretation of the data, together with new, previously unpublished observations revealing a marked impact on intestinal oxalate transport. Oxalates 95-102 renin Rattus norvegicus 140-143 26196539-4 2015 Because we hypothesized that streptozotocin-induced diabetes rats would show deficiencies in lung function, including surfactant proteins, and develop an imbalance of the renin-angiotensin system in the lungs. Streptozocin 29-43 renin Rattus norvegicus 171-176 26238503-10 2015 In addition, YQ inhibited the high mRNA expression level of renal renin, angiotensin II (Ang II), and Ang II receptor, type 1 (AT1R), and inhibited the protein expression of renal AT1R and Ang II receptor type 2, which had been induced by the HSF diet. Tyrosyl-Glutamine 13-15 renin Rattus norvegicus 66-71 26238503-11 2015 These results indicate that YQ may reduce the arterial pressure in salt-sensitive hypertension via the inhibition of renin-angiotensin system activation. Tyrosyl-Glutamine 28-30 renin Rattus norvegicus 117-122 26238503-11 2015 These results indicate that YQ may reduce the arterial pressure in salt-sensitive hypertension via the inhibition of renin-angiotensin system activation. Salts 67-71 renin Rattus norvegicus 117-122 24036520-7 2015 CONCLUSION: The combination of an aldosterone inhibitor with a direct renin inhibitor proved to be of greater benefit for cardiac structural and electrical remodeling in this experimental model of hypertension than aliskiren alone. aliskiren 215-224 renin Rattus norvegicus 70-75 24833625-2 2015 We tested whether aliskiren treatment in early postnatal life can reduce ADMA and regulate the renin-angiotensin system to prevent hypertension in rat offspring exposed to maternal caloric restriction (CR). aliskiren 18-27 renin Rattus norvegicus 95-100 24833625-8 2015 Renal renin and prorenin receptor (PRR) expression increased in CR rats treated with aliskiren, whereas both were reduced by losartan. aliskiren 85-94 renin Rattus norvegicus 6-11 25849601-14 2015 Renin-angiotensin-aldosterone system inhibition by aliskiren caused an increase in serum renin levels and a decrease in serum angiotensin II levels. aliskiren 51-60 renin Rattus norvegicus 0-5 26983216-5 2015 The results showed that ethyl acetate extract is the active part of Kansui Radix stir-baked with vinegar on the function of expelling water retention with drastic purgative on the cancerous ascites model rats, alleviating the water-electrolyte disorder and body fluid acid-base imbalance, regulating the renin angiotensin aldosterone system. ethyl acetate 24-37 renin Rattus norvegicus 304-309 25849601-14 2015 Renin-angiotensin-aldosterone system inhibition by aliskiren caused an increase in serum renin levels and a decrease in serum angiotensin II levels. aliskiren 51-60 renin Rattus norvegicus 89-94 26983216-5 2015 The results showed that ethyl acetate extract is the active part of Kansui Radix stir-baked with vinegar on the function of expelling water retention with drastic purgative on the cancerous ascites model rats, alleviating the water-electrolyte disorder and body fluid acid-base imbalance, regulating the renin angiotensin aldosterone system. Water 226-231 renin Rattus norvegicus 304-309 26244896-13 2015 However, renin inhibition (aliskiren) and an AT1R antagonist (losartan) significantly blocked EP-alveolar-bone loss in rats. aliskiren 27-36 renin Rattus norvegicus 9-14 26550169-0 2015 Captopril, an angiotensin-converting enzyme inhibitor, possesses chondroprotective efficacy in a rat model of osteoarthritis through suppression local renin-angiotensin system. Captopril 0-9 renin Rattus norvegicus 151-156 25911112-7 2015 Moreover, DBP short hairpin ribonucleic acid attenuated 1,25-(OH)2D3-induced attenuation of HG-induced renin (but not collagen IV and fibronectin) protein expression in NRK-49F cells. Calcitriol 56-68 renin Rattus norvegicus 103-108 25911112-10 2015 Moreover, DBP is required for vitamin D-induced attenuation of HG-induced renin in NRK-49F cells. Vitamin D 30-39 renin Rattus norvegicus 74-79 25780059-6 2015 We have demonstrated that renin and (P)RR are augmented in renal tissues from rats infused with Ang II and during sodium depletion, suggesting a physiological role in intrarenal RAS activation. Sodium 114-120 renin Rattus norvegicus 26-31 26410967-0 2015 Upregulation of the L-type Calcium Channel in Renin-Positive Smooth Muscle Cells of Arterioles in the Kidneys of Rats with Streptozotocin-Induced Diabetes. Streptozocin 123-137 renin Rattus norvegicus 46-51 25951330-0 2015 Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system. palmidrol 0-21 renin Rattus norvegicus 146-151 26025172-2 2015 The aim of this study was to investigate the impact of Lactobacillus salivarius Ren (Ren) in modulating colonic microbiota structure and colon cancer incidence in a rat model after injection with 1,2-dimethyl hydrazine (DMH). 1,2-Dimethylhydrazine 196-218 renin Rattus norvegicus 80-83 26025172-2 2015 The aim of this study was to investigate the impact of Lactobacillus salivarius Ren (Ren) in modulating colonic microbiota structure and colon cancer incidence in a rat model after injection with 1,2-dimethyl hydrazine (DMH). 1,2-Dimethylhydrazine 220-223 renin Rattus norvegicus 80-83 26025172-3 2015 The results indicated that oral administration of Ren could effectively suppress DMH-induced colonic carcinogenesis. 1,2-Dimethylhydrazine 81-84 renin Rattus norvegicus 50-53 26025172-5 2015 Using denaturing gradient gel electrophoresis and Real-time PCR combined with multivariate statistical methods, we demonstrated that injection with DMH significantly altered the rat gut microbiota, while Ren counteracted these DMH-induced adverse effects and promoted reversion of the gut microbiota close to the healthy state. 1,2-Dimethylhydrazine 227-230 renin Rattus norvegicus 204-207 25635129-0 2015 A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression. Salts 2-6 renin Rattus norvegicus 46-51 25635129-2 2015 We hypothesized that a salt-induced reno-cerebral reflex activates a renin-angiotensin axis to promote CKD. Salts 23-27 renin Rattus norvegicus 69-74 25635129-8 2015 These data suggest that the renal and cerebral renin-angiotensin axes are interlinked by a reno-cerebral reflex that is activated by salt and promotes oxidative stress, fibrosis, and progression of CKD independent of BP. Salts 133-137 renin Rattus norvegicus 47-52 25823676-4 2015 Calcitriol may exert a potential renoprotective effect by reducing the activity of the renin angiotensin system by suppressing renin gene expression and also by inhibiting the proinflammatory nuclear factor-kappaB pathway. Calcitriol 0-10 renin Rattus norvegicus 87-92 25823676-4 2015 Calcitriol may exert a potential renoprotective effect by reducing the activity of the renin angiotensin system by suppressing renin gene expression and also by inhibiting the proinflammatory nuclear factor-kappaB pathway. Calcitriol 0-10 renin Rattus norvegicus 127-132 25841323-8 2015 In summary, the results show that 5HT-mechanisms in the LPBN modulate sodium intake during the delay of SA when the renin angiotensin aldosterone system (RAAS) is increased. Serotonin 34-37 renin Rattus norvegicus 116-121 25841323-8 2015 In summary, the results show that 5HT-mechanisms in the LPBN modulate sodium intake during the delay of SA when the renin angiotensin aldosterone system (RAAS) is increased. Sodium 70-76 renin Rattus norvegicus 116-121 25841323-8 2015 In summary, the results show that 5HT-mechanisms in the LPBN modulate sodium intake during the delay of SA when the renin angiotensin aldosterone system (RAAS) is increased. sa 104-106 renin Rattus norvegicus 116-121 25369074-0 2015 Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol. Fructose 0-8 renin Rattus norvegicus 60-65 25369074-0 2015 Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol. Estradiol 159-168 renin Rattus norvegicus 60-65 25369074-3 2015 The aim of the study was to investigate the expression of the renin-angiotensin system molecules with potentially deleterious effect on the heart (angiotensin-converting enzyme and angiotensin II type 1 receptor) and those with potentially protective effects, (angiotensin-converting enzyme 2 and angiotensin II type 2 receptor), in ovariectomized fructose fed female rats with 17beta-estradiol replacement. Fructose 348-356 renin Rattus norvegicus 62-67 25369074-3 2015 The aim of the study was to investigate the expression of the renin-angiotensin system molecules with potentially deleterious effect on the heart (angiotensin-converting enzyme and angiotensin II type 1 receptor) and those with potentially protective effects, (angiotensin-converting enzyme 2 and angiotensin II type 2 receptor), in ovariectomized fructose fed female rats with 17beta-estradiol replacement. Estradiol 378-394 renin Rattus norvegicus 62-67 25369074-6 2015 On the other hand, estradiol replacement seems to undo fructose diet effects on cardiac renin-angiotensin system. Fructose 55-63 renin Rattus norvegicus 88-93 25369074-8 2015 Obtained results suggest that estradiol may reverse the harmful effect of fructose-rich diet on the expression of renin-angiotensin system molecules. Estradiol 30-39 renin Rattus norvegicus 114-119 25369074-8 2015 Obtained results suggest that estradiol may reverse the harmful effect of fructose-rich diet on the expression of renin-angiotensin system molecules. Fructose 74-82 renin Rattus norvegicus 114-119 25712636-1 2015 BACKGROUND: Aliskiren is the first orally active inhibitor of renin to be approved for clinical use as an antihypertensive agent. aliskiren 12-21 renin Rattus norvegicus 62-67 25658458-9 2015 In conclusion, stimulation of PPARalpha by clofibrate prevents an increase in the activity of renin-angiotensin system and promotes the production of vasodilator substances. Clofibrate 43-53 renin Rattus norvegicus 94-99 25707593-9 2015 These effects occurred in the presence of the AT1R blocker candesartan (10 mumol/L) and the renin inhibitor aliskiren (10 mumol/L). aliskiren 108-117 renin Rattus norvegicus 92-97 25905591-14 2015 This study suggests that polydatin may attenuate ventricular remodeling after myocardial infarction in coronary artery ligation rats through restricting the excessive activation of the renin-angiotensin-aldosterone system and inhibiting peroxidation. polydatin 25-34 renin Rattus norvegicus 185-190 25761067-0 2015 Early co-expression of cyclooxygenase-2 and renin in the rat kidney cortex contributes to the development of N(G)-nitro-L-arginine methyl ester induced hypertension. NG-Nitroarginine Methyl Ester 109-143 renin Rattus norvegicus 44-49 25761067-1 2015 We investigated the involvement of cyclooxygenase-2 (COX-2) and the renin-angiotensin system in N(G)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension. NG-Nitroarginine Methyl Ester 132-138 renin Rattus norvegicus 68-73 25761067-5 2015 We found a parallel increase in renocortical COX-2 and renin mRNA starting at day 2 of treatment with L-NAME, and both peaked at 19-25 days. NG-Nitroarginine Methyl Ester 102-108 renin Rattus norvegicus 55-60 25624342-3 2015 The Dahl salt-sensitive rat is a paradigm of salt-sensitive hypertension associated with local activation of the renin-angiotensin system. dahl salt 4-13 renin Rattus norvegicus 113-118 25624342-3 2015 The Dahl salt-sensitive rat is a paradigm of salt-sensitive hypertension associated with local activation of the renin-angiotensin system. Salts 9-13 renin Rattus norvegicus 113-118 25799069-0 2015 High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. Salts 5-9 renin Rattus norvegicus 71-76 25534694-7 2015 DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. Desoxycorticosterone Acetate 0-4 renin Rattus norvegicus 37-42 25799069-2 2015 We hypothesized that a high salt intake activates the cardiac tissue renin angiotensin system and prorenin-(pro)renin receptor system, and damages the heart at an early stage of hypertension. Salts 28-32 renin Rattus norvegicus 69-74 25799069-2 2015 We hypothesized that a high salt intake activates the cardiac tissue renin angiotensin system and prorenin-(pro)renin receptor system, and damages the heart at an early stage of hypertension. Salts 28-32 renin Rattus norvegicus 101-106 25799069-10 2015 CONCLUSION: The high-salt diet markedly accelerated cardiac damage through the stimulation of cardiac (P)RR and angiotensin II AT1 receptor by increasing tissue prorenin, renin and angiotensinogen and the activation of ERK1/2, TGF-beta, p38MAPK and HSP27 under higher blood pressure. Salts 21-25 renin Rattus norvegicus 164-169 25885968-11 2015 Real-time PCR and Western blot analysis of the female brain revealed that DOCA/salt treatment enhanced the mRNA and protein expression for both antihypertensive components including AT2-R, angiotensin-converting enzyme (ACE)-2, and interleukin (IL)-10 and hypertensive components including angiotensin receptor type 1 (AT1-R), ACE-1, tumor necrosis factor (TNF)-alpha, and IL-1beta, but decreased mRNA expression of renin in the PVN. Desoxycorticosterone Acetate 74-78 renin Rattus norvegicus 416-421 25885968-11 2015 Real-time PCR and Western blot analysis of the female brain revealed that DOCA/salt treatment enhanced the mRNA and protein expression for both antihypertensive components including AT2-R, angiotensin-converting enzyme (ACE)-2, and interleukin (IL)-10 and hypertensive components including angiotensin receptor type 1 (AT1-R), ACE-1, tumor necrosis factor (TNF)-alpha, and IL-1beta, but decreased mRNA expression of renin in the PVN. Salts 79-83 renin Rattus norvegicus 416-421 25187428-8 2015 In cirrhotic rats, vitamin D3 administration decreasing IHR by inhibiting the renin-angiotensin system, hepatic oxidative stress, inflammation/fibrosis, angiotensin II (ANGII) production, CaSR-mediated ANGII hyperresponsiveness, ANGII-induced hepatic stellate cells contraction, and correcting hepatic endothelial dysfunction through upregulation of hepatic VDR, CaSR, and endothelial nitric oxide synthase expressions. Cholecalciferol 19-29 renin Rattus norvegicus 78-83 25686347-0 2015 [Up-regulation of intrarenal renin-angiotensin system contributes to renal damage in high-salt induced hypertension rats]. Salts 90-94 renin Rattus norvegicus 29-34 25973045-7 2015 The STZ injection significantly up-regulated mRNA expression of AT1R, AGT, renin, renin-receptor, and ACE, and the expression of AT2R, B1R and B2R were down-regulated in tibia of rat in hyperglycemia group. Streptozocin 4-7 renin Rattus norvegicus 75-80 25657639-2 2014 HighlightsIntracellular renin disrupts chemical communication in the heartAngiotensinogen enhances the effect of reninIntracellular enalaprilat reduces significantly the effect of reninIntracellular renin increases the inward calcium currentHarmful versus beneficial effect during myocardial infarction The influence of intracellular renin on the process of chemical communication between cardiac cells was investigated in cell pairs isolated from the left ventricle of adult Wistar Kyoto rats. Calcium 226-233 renin Rattus norvegicus 24-29 25797993-7 2015 Both the ratio of plasma aldosterone concentration to plasma renin activity and cardiac expression of the MR and serum/glucocorticoid-regulated kinase 1 genes were decreased to a greater extent by eplerenone than by tempol. Eplerenone 197-207 renin Rattus norvegicus 61-66 25380481-6 2015 CONCLUSION: Putative master genes exhibiting changes in both gene expression and DNA methylation are limited to 266 genes and are mainly involved in the renin-angiotensin system (n = 3), mitochondrion metabolism (n = 18), and phospholipid homeostasis (n = 3). Phospholipids 226-238 renin Rattus norvegicus 153-158 25657639-2 2014 HighlightsIntracellular renin disrupts chemical communication in the heartAngiotensinogen enhances the effect of reninIntracellular enalaprilat reduces significantly the effect of reninIntracellular renin increases the inward calcium currentHarmful versus beneficial effect during myocardial infarction The influence of intracellular renin on the process of chemical communication between cardiac cells was investigated in cell pairs isolated from the left ventricle of adult Wistar Kyoto rats. Calcium 226-233 renin Rattus norvegicus 113-118 25657639-2 2014 HighlightsIntracellular renin disrupts chemical communication in the heartAngiotensinogen enhances the effect of reninIntracellular enalaprilat reduces significantly the effect of reninIntracellular renin increases the inward calcium currentHarmful versus beneficial effect during myocardial infarction The influence of intracellular renin on the process of chemical communication between cardiac cells was investigated in cell pairs isolated from the left ventricle of adult Wistar Kyoto rats. Calcium 226-233 renin Rattus norvegicus 113-118 25463381-5 2014 Subsequently, activation of the mineralocorticoid receptor in the renin-angiotensin-aldosterone-electrolyte system was associated with an increased cortisol level. Hydrocortisone 148-156 renin Rattus norvegicus 66-71 25468497-1 2015 Histamine, acting centrally as a neurotransmitter, evokes a reversal of hemorrhagic hypotension in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides. Histamine 0-9 renin Rattus norvegicus 153-158 25394830-0 2015 Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression. Corticosterone 55-69 renin Rattus norvegicus 0-5 25394830-1 2015 The classic renin-angiotensin system is partly responsible for controlling aldosterone secretion from the adrenal cortex via the peptide angiotensin II (ANG II). Aldosterone 75-86 renin Rattus norvegicus 12-17 25394830-2 2015 In addition, there is a local adrenocortical renin-angiotensin system that may be involved in the control of aldosterone synthesis in the zona glomerulosa (ZG). Aldosterone 109-120 renin Rattus norvegicus 45-50 25394830-6 2015 Basal and cAMP-stimulated aldosterone production was significantly reduced in renin KO ZG cells, whereas corticosterone production was not different between WT and KO ZFR cells. Cyclic AMP 10-14 renin Rattus norvegicus 78-83 25470515-4 2015 The effect of Na(2)S in decreasing MAP was less pronounced in the presence of captopril (2 micromol/l), which may indicate that the renin-angiotensin system is partially involved in the Na(2)S effect. sodium sulfide 14-20 renin Rattus norvegicus 132-137 25470515-4 2015 The effect of Na(2)S in decreasing MAP was less pronounced in the presence of captopril (2 micromol/l), which may indicate that the renin-angiotensin system is partially involved in the Na(2)S effect. Captopril 78-87 renin Rattus norvegicus 132-137 25224811-3 2014 AngII-dependent malignant hypertension was induced by 10 days" dietary administration of indole-3-carbinol (I3C), a natural xenobiotic that activates the mouse renin gene in Cyp1a1-Ren-2 transgenic rats. indole-3-carbinol 89-106 renin Rattus norvegicus 160-165 25196678-2 2014 METHODS: Diabetes was induced with streptozotocin in Cyp1a1mRen2 rats and hypertension was generated by inducing renin transgene expression with dietary indole-3-carbinol (I-3-C) for 28 weeks. indole-3-carbinol 153-170 renin Rattus norvegicus 113-118 23420778-0 2014 Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats. aliskiren 53-62 renin Rattus norvegicus 37-42 25199528-2 2014 Olmesartan (OLM; angiotensin receptor blocker) and aliskiren (ALK; renin inhibitor) may attenuate cardiotoxicity induced by TAC by inhibition of renin-angiotensin aldosterone system. olmesartan 0-10 renin Rattus norvegicus 145-150 25199528-2 2014 Olmesartan (OLM; angiotensin receptor blocker) and aliskiren (ALK; renin inhibitor) may attenuate cardiotoxicity induced by TAC by inhibition of renin-angiotensin aldosterone system. aliskiren 51-60 renin Rattus norvegicus 67-72 25199528-2 2014 Olmesartan (OLM; angiotensin receptor blocker) and aliskiren (ALK; renin inhibitor) may attenuate cardiotoxicity induced by TAC by inhibition of renin-angiotensin aldosterone system. aliskiren 51-60 renin Rattus norvegicus 145-150 25343458-0 2014 Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells. Indican 0-15 renin Rattus norvegicus 43-48 25131447-3 2014 We also investigated the beneficial effects of a novel renin inhibitor, aliskiren, against stroke-elicited pressor response. aliskiren 72-81 renin Rattus norvegicus 55-60 25164822-8 2014 Moreover, H2S was also found to inhibit the renin-angiotensin system in diabetic kidney. Hydrogen Sulfide 10-13 renin Rattus norvegicus 44-49 25164822-9 2014 In conclusion, our study demonstrates that H2S alleviates the development of diabetic nephropathy by attenuating oxidative stress and inflammation, reducing mesangial cell proliferation, and inhibiting renin-angiotensin system activity. Hydrogen Sulfide 43-46 renin Rattus norvegicus 202-207 25012132-0 2014 Retinal vasculopathy is reduced by dietary salt restriction: involvement of Glia, ENaCalpha, and the renin-angiotensin-aldosterone system. Salts 43-47 renin Rattus norvegicus 101-106 25339484-0 2014 Paricalcitol counteracts the increased contrast induced nephropathy caused by renin-angiotensin-aldosterone system blockade therapy in a rat model. paricalcitol 0-12 renin Rattus norvegicus 78-83 25371525-1 2014 The aim of this study was to determine the effectory mechanisms: vasopressin, renin-angiotensin system and proopiomelanocortin-derived peptides (POMC), partaking in the effects of serotonin through central serotonin 1A receptor (5-HT1A) receptors in haemorrhagic shock in rats. Serotonin 180-189 renin Rattus norvegicus 78-83 25012132-2 2014 A high-salt diet is causal in cardiovascular and renal disease, which is linked to modulation of the renin-angiotensin-aldosterone system. Salts 7-11 renin Rattus norvegicus 101-106 24959250-9 2014 These observations suggested that captopril prevents the development of ACF by inhibiting renin-angiotensin system activation and attenuating inflammation and oxidative stress in SHRSP-ZF rats. Captopril 34-43 renin Rattus norvegicus 90-95 25012132-13 2014 CONCLUSIONS: An LS diet reduced retinal vasculopathy, by modulating glial cell function and the retinal renin-angiotensin-aldosterone system. leucylserine 16-18 renin Rattus norvegicus 104-109 24979301-0 2014 High phosphate diet increases arterial blood pressure via a parathyroid hormone mediated increase of renin. Phosphates 5-14 renin Rattus norvegicus 101-106 24979301-6 2014 The addition of the phosphate binder blunted the increase in renin and Ang II levels. Phosphates 20-29 renin Rattus norvegicus 61-77 24979301-12 2014 CONCLUSION: The results of this study suggest that a high phosphate diet increases arterial blood pressure through an increase in renin mediated by PTH. Phosphates 58-67 renin Rattus norvegicus 130-135 25056788-0 2014 Indoxyl sulfate induces renin release and apoptosis of kidney mesangial cells. Indican 0-15 renin Rattus norvegicus 24-29 25056788-8 2014 The mRNA expressions of pro-renin and ACE were upregulated in mesangial cells exposed to indoxyl sulfate. Indican 89-104 renin Rattus norvegicus 28-33 25056788-9 2014 Level of renin and ACE was increased in response to indoxyl sulfate exposure in time-dependent fashion. Indican 52-67 renin Rattus norvegicus 9-14 24740788-4 2014 When the cells were pretreated with a COX-2 inhibitor NS-398, ANG II-induced upregulation of PRR protein expression was almost completely abolished, in parallel with the changes in medium active renin content. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 54-60 renin Rattus norvegicus 195-200 24740788-6 2014 A 14-day ANG II infusion elevated renal medullary PRR expression and active and total renin content in parallel with increased urinary renin, all of which were remarkably suppressed by the COX-2 inhibitor celecoxib. Celecoxib 205-214 renin Rattus norvegicus 86-91 24740788-6 2014 A 14-day ANG II infusion elevated renal medullary PRR expression and active and total renin content in parallel with increased urinary renin, all of which were remarkably suppressed by the COX-2 inhibitor celecoxib. Celecoxib 205-214 renin Rattus norvegicus 135-140 24222043-1 2014 Previous hypertension studies have shown that low levels of vitamin D are linked to elevated renin-angiotensin system. Vitamin D 60-69 renin Rattus norvegicus 93-98 25422756-0 2014 The role of local renin-angiotensin system on high glucose-induced cell toxicity, apoptosis and reactive oxygen species production in PC12 cells. Glucose 51-58 renin Rattus norvegicus 18-23 25422756-4 2014 This study aimed to investigate the role of local renin-angiotensin system on high glucose-induced cell toxicity, apoptosis and reactive oxygen species (ROS) production in PC12 cells, as a cell model of diabetic neuropathy. Glucose 83-90 renin Rattus norvegicus 50-55 25422756-4 2014 This study aimed to investigate the role of local renin-angiotensin system on high glucose-induced cell toxicity, apoptosis and reactive oxygen species (ROS) production in PC12 cells, as a cell model of diabetic neuropathy. Reactive Oxygen Species 128-151 renin Rattus norvegicus 50-55 25048368-0 2014 Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system. Vitamin D 0-9 renin Rattus norvegicus 128-133 25048368-2 2014 Vitamin D has been associated with renal and cardiovascular diseases because of its effects on oxidative stress, lipid metabolism and renin-angiotensin-aldosterone system (RAAS). Vitamin D 0-9 renin Rattus norvegicus 134-139 25015438-11 2014 Renin angiotensin blockers significantly improve the metabolism and oxidative dysfunctions in Type 2 DM and aliskiren may show a promising powerful therapy. aliskiren 108-117 renin Rattus norvegicus 0-5 24894399-2 2014 The aim of this study was to assess whether blockade of the renin-angiotensin system ameliorated these effects in rats with oxygen induced retinopathy (OIR). Oxygen 124-130 renin Rattus norvegicus 60-65 24072555-0 2014 Paricalcitol downregulates myocardial renin-angiotensin and fibroblast growth factor expression and attenuates cardiac hypertrophy in uremic rats. paricalcitol 0-12 renin Rattus norvegicus 38-43 24072555-1 2014 BACKGROUND: Vitamin D attenuates uremic cardiac hypertrophy, possibly by suppressing the myocardial renin-angiotensin system (RAS) and fibroblast growth factors (FGFs). Vitamin D 12-21 renin Rattus norvegicus 100-105 24601883-0 2014 Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-beta1 and alpha-smooth muscle actin in proximal tubular cells. Indican 0-15 renin Rattus norvegicus 43-48 24601883-5 2014 Furthermore, administration of indoxyl sulfate to normotensive and hypertensive rats increased renal expression of PRR and renin/prorenin. Indican 31-46 renin Rattus norvegicus 123-128 25050166-0 2014 Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors. Piperidines 38-49 renin Rattus norvegicus 99-104 24709336-0 2014 Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury. aliskiren 30-39 renin Rattus norvegicus 14-19 24709336-1 2014 The purpose of this study was to investigate the effect of the renin inhibitor, aliskiren, on retinal ischemia-reperfusion injury. aliskiren 80-89 renin Rattus norvegicus 63-68 24709336-6 2014 Rats were treated with the renin inhibitor, aliskiren. aliskiren 44-53 renin Rattus norvegicus 27-32 24502693-15 2014 The decrease in ATP level was restored by treatment with inhibitors of ACE and renin. Adenosine Triphosphate 16-19 renin Rattus norvegicus 79-84 25050166-1 2014 A cis-configured 3,5-disubstituted piperidine direct renin inhibitor, (syn,rac)-1, was discovered as a high-throughput screening hit from a target-family tailored library. cis-configured 3,5-disubstituted piperidine 2-45 renin Rattus norvegicus 53-58 24388840-1 2014 Juvenile rat toxicity studies with the direct renin inhibitor aliskiren were initiated to support treatment in the pediatric population. aliskiren 62-71 renin Rattus norvegicus 46-51 24436324-9 2014 Methylglyoxal level and protein and mRNA for angiotensin, AT1 receptor, adrenergic alpha1D receptor, and renin were significantly increased in the aorta and/or kidney of methylglyoxal-treated rats, a novel finding. Pyruvaldehyde 170-183 renin Rattus norvegicus 105-110 24436324-14 2014 CONCLUSIONS: Methylglyoxal activates NF-kappaB through RAGE and thereby increases renin-angiotensin levels, a novel finding, and a probable mechanism of increase in blood pressure. Pyruvaldehyde 13-26 renin Rattus norvegicus 82-87 24692426-1 2014 BACKGROUND: Aliskiren is the first orally bioavailable direct renin inhibitor approved for the treatment of hypertension in adults. aliskiren 12-21 renin Rattus norvegicus 62-67 24420538-2 2014 The renin inhibitor aliskiren increases cardiac tissue kallikrein and bradykinin levels. aliskiren 20-29 renin Rattus norvegicus 4-9 24140549-0 2014 The synergistic effect of mizoribine and a direct renin inhibitor, aliskiren, on unilateral ureteral obstruction induced renal fibrosis in rats. aliskiren 67-76 renin Rattus norvegicus 50-55 24603692-8 2014 Molecular docking studies confirmed that the higher renin-inhibitory activity of RALP may be due to formation of several hydrogen bonds (H-bonds) with the enzyme"s active site residues. Hydrogen 121-129 renin Rattus norvegicus 52-57 24436324-0 2014 Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats. Pyruvaldehyde 0-13 renin Rattus norvegicus 56-61 24436324-8 2014 RESULTS: Methylglyoxal-treated rats developed a significant increase in blood pressure and plasma levels of aldosterone, renin, angiotensin, and catecholamines. Pyruvaldehyde 9-22 renin Rattus norvegicus 121-126 24291173-2 2014 Olmesartan has significant blood pressure lowering effect via modulating renin-angiotensin system although its mechanism of action in DNR-induced renal injury is largely unknown. olmesartan 0-10 renin Rattus norvegicus 73-78 23581627-0 2014 Hydrogen sulfide prevents heart failure development via inhibition of renin release from mast cells in isoproterenol-treated rats. Hydrogen Sulfide 0-16 renin Rattus norvegicus 70-75 23581627-0 2014 Hydrogen sulfide prevents heart failure development via inhibition of renin release from mast cells in isoproterenol-treated rats. Isoproterenol 103-116 renin Rattus norvegicus 70-75 23581627-2 2014 We previously reported that hydrogen sulfide (H2S), an endogenous gaseous mediator, regulates renin synthesis and release in juxtaglomerular cells. Hydrogen Sulfide 28-44 renin Rattus norvegicus 94-99 23581627-2 2014 We previously reported that hydrogen sulfide (H2S), an endogenous gaseous mediator, regulates renin synthesis and release in juxtaglomerular cells. Hydrogen Sulfide 46-49 renin Rattus norvegicus 94-99 23581627-3 2014 The present study was designed to investigate whether H2S can protect against isoproterenol (ISO)-induced heart failure via inhibition of local renin activity in rat hearts. Hydrogen Sulfide 54-57 renin Rattus norvegicus 144-149 23581627-3 2014 The present study was designed to investigate whether H2S can protect against isoproterenol (ISO)-induced heart failure via inhibition of local renin activity in rat hearts. Isoproterenol 93-96 renin Rattus norvegicus 144-149 23581627-7 2014 Moreover, NaHS treatment reversed ISO-induced renin elevation in both plasma and LVs. sodium bisulfide 10-14 renin Rattus norvegicus 46-51 23581627-12 2014 CONCLUSIONS: For the first time, we demonstrated that H2S might protect heart during heart failure by suppression of local renin level through inhibition of both mast cell infiltration and renin degranulation. Hydrogen Sulfide 54-57 renin Rattus norvegicus 123-128 23581627-12 2014 CONCLUSIONS: For the first time, we demonstrated that H2S might protect heart during heart failure by suppression of local renin level through inhibition of both mast cell infiltration and renin degranulation. Hydrogen Sulfide 54-57 renin Rattus norvegicus 189-194 24188244-0 2014 Salt sensitivity of renin secretion, glomerular filtration rate and blood pressure in conscious Sprague-Dawley rats. Salts 0-4 renin Rattus norvegicus 20-25 24188244-1 2014 AIM: We hypothesized that in normal rats in metabolic steady state, (i) the plasma renin concentration (PRC) is log-linearly related to Na(+) intake (NaI), (ii) the concurrent changes in mean arterial pressure (MABP) and glomerular filtration rate (GFR) are negligible and (iii) the function PRC = f(NaI) is altered by beta1-adrenoceptor blockade (metoprolol) and surgical renal denervation (DNX). nai 150-153 renin Rattus norvegicus 83-88 24188244-1 2014 AIM: We hypothesized that in normal rats in metabolic steady state, (i) the plasma renin concentration (PRC) is log-linearly related to Na(+) intake (NaI), (ii) the concurrent changes in mean arterial pressure (MABP) and glomerular filtration rate (GFR) are negligible and (iii) the function PRC = f(NaI) is altered by beta1-adrenoceptor blockade (metoprolol) and surgical renal denervation (DNX). nai 300-303 renin Rattus norvegicus 83-88 24188244-1 2014 AIM: We hypothesized that in normal rats in metabolic steady state, (i) the plasma renin concentration (PRC) is log-linearly related to Na(+) intake (NaI), (ii) the concurrent changes in mean arterial pressure (MABP) and glomerular filtration rate (GFR) are negligible and (iii) the function PRC = f(NaI) is altered by beta1-adrenoceptor blockade (metoprolol) and surgical renal denervation (DNX). Metoprolol 348-358 renin Rattus norvegicus 83-88 24188244-1 2014 AIM: We hypothesized that in normal rats in metabolic steady state, (i) the plasma renin concentration (PRC) is log-linearly related to Na(+) intake (NaI), (ii) the concurrent changes in mean arterial pressure (MABP) and glomerular filtration rate (GFR) are negligible and (iii) the function PRC = f(NaI) is altered by beta1-adrenoceptor blockade (metoprolol) and surgical renal denervation (DNX). fluorescent bezafibrate 392-395 renin Rattus norvegicus 83-88 25531334-0 2014 Up-regulation of intrarenal renin-agiotensin system contributes to renal damage in high-salt induced hypertension rats. Salts 88-92 renin Rattus norvegicus 28-33 24337709-0 2014 High glucose induces activation of the local renin-angiotensin system in glomerular endothelial cells. Glucose 5-12 renin Rattus norvegicus 45-50 24473199-1 2014 BACKGROUND: We tested the hypothesis that direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion (I/R) injury in spontaneously hypertensive rats (SHR), and examined the mechanism by which this occurs. aliskiren 71-80 renin Rattus norvegicus 49-54 24520203-0 2014 Recruited renin-containing renal microvascular cells demonstrate the calcium paradox regulatory phenotype. Calcium 69-76 renin Rattus norvegicus 10-15 24520203-2 2014 Chronic sodium deprivation enhances renin secretion from the kidney, due to recruitment of additional cells from the afferent renal microvasculature to become renin-producing rather than just increasing release from existing juxtaglomerular (JG) cells. Sodium 8-14 renin Rattus norvegicus 36-41 24520203-2 2014 Chronic sodium deprivation enhances renin secretion from the kidney, due to recruitment of additional cells from the afferent renal microvasculature to become renin-producing rather than just increasing release from existing juxtaglomerular (JG) cells. Sodium 8-14 renin Rattus norvegicus 159-164 24520203-3 2014 JG cells secrete renin inversely proportional to extra- and intracellular calcium, a unique phenomenon characteristic of the JG regulatory phenotype known as the "calcium paradox." Calcium 74-81 renin Rattus norvegicus 17-22 24520203-3 2014 JG cells secrete renin inversely proportional to extra- and intracellular calcium, a unique phenomenon characteristic of the JG regulatory phenotype known as the "calcium paradox." Calcium 163-170 renin Rattus norvegicus 17-22 24520203-5 2014 We hypothesized that non-JG cells in renal microvessels recruited to produce renin in response to chronic dietary sodium restriction would demonstrate the calcium paradox, characteristic of the JG cell phenotype. Sodium 114-120 renin Rattus norvegicus 77-82 24520203-5 2014 We hypothesized that non-JG cells in renal microvessels recruited to produce renin in response to chronic dietary sodium restriction would demonstrate the calcium paradox, characteristic of the JG cell phenotype. Calcium 155-162 renin Rattus norvegicus 77-82 24520203-6 2014 Histology showed recruitment of upstream arteriolar renin in response to sodium restriction compared to normal-diet rats. Sodium 73-79 renin Rattus norvegicus 52-57 24520203-7 2014 Renin fluorescence intensity increased 53% in cortices of sodium-restricted rats (P<0.001). Sodium 58-64 renin Rattus norvegicus 0-5 24520203-9 2014 Basal renin release from normal sodium-diet rat microvessels in normal calcium media was 298.1+-44.6 ng AngI/mL/hour/mg protein, and in low-calcium media increased 39% to 415.9+-71.4 ng AngI/mL/hour/mg protein (P<0.025). Sodium 32-38 renin Rattus norvegicus 6-11 24520203-9 2014 Basal renin release from normal sodium-diet rat microvessels in normal calcium media was 298.1+-44.6 ng AngI/mL/hour/mg protein, and in low-calcium media increased 39% to 415.9+-71.4 ng AngI/mL/hour/mg protein (P<0.025). Calcium 71-78 renin Rattus norvegicus 6-11 24520203-10 2014 Renin released from sodium-restricted rat microvessels increased 50% compared to samples from normal-diet rats (P<0.04). Sodium 20-26 renin Rattus norvegicus 0-5 24520203-11 2014 Renin release in normal calcium media was 447.0+-54.3 ng AngI/mL/hour/mg protein, and in low-calcium media increased 36% to 607.6+-96.1 ng AngI/mL/hour/mg protein (P<0.05). Calcium 24-31 renin Rattus norvegicus 0-5 24520203-12 2014 Thus, renin-containing cells recruited in the afferent microvasculature not only express and secrete renin but demonstrate the calcium paradox, suggesting renin secretion from recruited renin-containing cells share the JG phenotype for regulating renin secretion. Calcium 127-134 renin Rattus norvegicus 6-11 25322648-0 2014 [Interaction of renin-angiotensin system inhibitors with dopamine in rat kidney]. Dopamine 57-65 renin Rattus norvegicus 16-21 25322648-4 2014 Preliminary administration of the direct renin inhibitor aliskiren (4 mg/kg, p.o., for 7 days) is accompanied by 6-fold increase in the diuretic effect of dopamine and increases natriuresis 7.2 times and urine potassium excretion 7 times (p < 0.05). aliskiren 57-66 renin Rattus norvegicus 41-46 25322648-4 2014 Preliminary administration of the direct renin inhibitor aliskiren (4 mg/kg, p.o., for 7 days) is accompanied by 6-fold increase in the diuretic effect of dopamine and increases natriuresis 7.2 times and urine potassium excretion 7 times (p < 0.05). Dopamine 155-163 renin Rattus norvegicus 41-46 25322648-5 2014 It is concluded that renin-angiotensin system (RAS) of renal tissues is involved in the mechanism of dopamine action in the kidney, acting as a modulator that prevents excessive loss of water and electrolytes with urine. Dopamine 101-109 renin Rattus norvegicus 21-26 25322648-5 2014 It is concluded that renin-angiotensin system (RAS) of renal tissues is involved in the mechanism of dopamine action in the kidney, acting as a modulator that prevents excessive loss of water and electrolytes with urine. Water 186-191 renin Rattus norvegicus 21-26 24166752-0 2014 Transient neonatal high oxygen exposure leads to early adult cardiac dysfunction, remodeling, and activation of the renin-angiotensin system. Oxygen 24-30 renin Rattus norvegicus 116-121 24166752-2 2014 Transient neonatal high O(2) exposure in rat in adulthood (a model of preterm birth-related complications) leads to elevated blood pressure, vascular rigidity, and dysfunction with renin-angiotensin system activation. Oxygen 24-28 renin Rattus norvegicus 181-186 24257807-10 2014 Repeated intravenous MSCs transplantation could improve cardiac function by attenuating myocardial collagen network remodeling possibly through downregulating renin-angiotensin-aldosterone system in DOX-induced DCM rats. Doxorubicin 199-202 renin Rattus norvegicus 159-164 24172819-6 2014 Repeated treatment with phenytoin led to adrenal gland hypertrophy as well as to a marginal increase in plasma renin activity. Phenytoin 24-33 renin Rattus norvegicus 111-116 24172819-10 2014 It cannot be excluded that the phenytoin-induced increase in plasma renin activity observed in the present study may occur during therapeutic use of phenytoin and contribute to its adverse effects. Phenytoin 31-40 renin Rattus norvegicus 68-73 24172819-10 2014 It cannot be excluded that the phenytoin-induced increase in plasma renin activity observed in the present study may occur during therapeutic use of phenytoin and contribute to its adverse effects. Phenytoin 149-158 renin Rattus norvegicus 68-73 25531334-1 2014 BACKGROUND/AIMS: To investigate the change of intrarenal renin-agiotensin system (RAS) and its role in high-salt induced hypertension. Salts 108-112 renin Rattus norvegicus 57-62 25531334-10 2014 In HS+L, Losartan failed to reduce SBP (P>0.05) but abolished the increase of proteinuria (P<0.01), renal cortex renin, AGT, Ang II and urinary AGT reduced (P<0.05) while plasma renin, AGT and Ang II enhanced (P<0.05) when compared with HS. Losartan 9-17 renin Rattus norvegicus 119-124 25531334-10 2014 In HS+L, Losartan failed to reduce SBP (P>0.05) but abolished the increase of proteinuria (P<0.01), renal cortex renin, AGT, Ang II and urinary AGT reduced (P<0.05) while plasma renin, AGT and Ang II enhanced (P<0.05) when compared with HS. Losartan 9-17 renin Rattus norvegicus 187-192 23448275-0 2013 Direct renin inhibitor, aliskiren, attenuates the progression of non-alcoholic steatohepatitis in the rat model. aliskiren 24-33 renin Rattus norvegicus 7-12 24864188-7 2014 Melatonin prevented CR-induced renin and prorenin receptor expression. Melatonin 0-9 renin Rattus norvegicus 31-36 24864188-10 2014 Conclusively, we attributed these protective effects of melatonin on CR-induced programmed hypertension to the reduction of plasma ADMA, restoration of plasma AAR, increase of renal NO level, alteration of renin-angiotensin system, and epigenetic changes in numerous genes. Melatonin 56-65 renin Rattus norvegicus 206-211 23934707-5 2013 Switching to HS (4% NaCl) diet for 3 days to reduce plasma renin activity (PRA) eliminated vasodilation to ACh and reduced PO2 in sham-operated controls, with no effect on vasodilation in 2K1C rats. Sodium Chloride 20-24 renin Rattus norvegicus 59-64 23934707-5 2013 Switching to HS (4% NaCl) diet for 3 days to reduce plasma renin activity (PRA) eliminated vasodilation to ACh and reduced PO2 in sham-operated controls, with no effect on vasodilation in 2K1C rats. Acetylcholine 107-110 renin Rattus norvegicus 59-64 23934707-5 2013 Switching to HS (4% NaCl) diet for 3 days to reduce plasma renin activity (PRA) eliminated vasodilation to ACh and reduced PO2 in sham-operated controls, with no effect on vasodilation in 2K1C rats. PO-2 123-126 renin Rattus norvegicus 59-64 23448275-3 2013 The aim of the current study was to examine the effect of the clinically used direct renin inhibitor (DRI), aliskiren, on the progression of NASH in a rat model. aliskiren 108-117 renin Rattus norvegicus 85-90 24970730-0 2013 Maternal vitamin D deficiency programmes adult renal renin gene expression and renal function. Vitamin D 9-18 renin Rattus norvegicus 53-58 24970730-1 2013 Renin is essential for renal development and in adult kidneys vitamin D deficiency increases renin gene expression. Vitamin D 62-71 renin Rattus norvegicus 0-5 24970730-1 2013 Renin is essential for renal development and in adult kidneys vitamin D deficiency increases renin gene expression. Vitamin D 62-71 renin Rattus norvegicus 93-98 24970730-2 2013 We aimed to determine whether maternal vitamin D deficiency upregulates fetal renal renin expression, and if this is sustained. Vitamin D 39-48 renin Rattus norvegicus 84-89 24970730-11 2013 We conclude that maternal vitamin D depletion upregulates fetal renal renin gene expression and this persists into adulthood where, in males only, there is evidence of sodium retention and compromised renal function. Vitamin D 26-35 renin Rattus norvegicus 70-75 23886807-0 2013 Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors. (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamide 36-114 renin Rattus norvegicus 132-137 23726047-7 2013 Angiotensin II-synthesizing proteins renin and angiotensinogen were largely absent after saline but abundant in T cells and macrophages in CFA-injected paws with or without PD123319. Sodium Chloride 89-95 renin Rattus norvegicus 37-42 23726047-7 2013 Angiotensin II-synthesizing proteins renin and angiotensinogen were largely absent after saline but abundant in T cells and macrophages in CFA-injected paws with or without PD123319. PD 123319 173-181 renin Rattus norvegicus 37-42 23886807-1 2013 We report synthesis and optimization of a series of (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamide 52-130 renin Rattus norvegicus 134-139 23886807-2 2013 Chemical modification of P1", P2" and P3 portions led to a promising 3,5-disubstituted piperidine 32o showing high renin inhibitory activity and favorable oral exposure in both rats and cynomolgus monkeys with acceptable CYP and hERG current inhibition. 3,5-disubstituted piperidine 32o 69-101 renin Rattus norvegicus 115-120 23628455-11 2013 The renin-angiotensin-aldosterone system participates in the impaired coronary relaxation in aged SHR, but does not partake in this deleterious effect under increased salt intake, indicating that age could differentiate the effects of high sodium intake in coronary arteries of SHR. Sodium 240-246 renin Rattus norvegicus 4-9 24040205-0 2013 Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats. Fructose 83-91 renin Rattus norvegicus 55-60 24040205-9 2013 Methylglyoxal level and protein and mRNA for angiotensin II, AT1 receptor, adrenergic alpha1D receptor and renin were significantly increased, whereas GSH levels were decreased, in the aorta and/or kidney of fructose fed rats. Fructose 208-216 renin Rattus norvegicus 107-112 24040205-13 2013 In conclusion, we report a strong association between elevated levels of methylglyoxal, RAGE, NF-kappaB, mediators of the renin angiotensin system and blood pressure in high fructose diet fed rats. Fructose 174-182 renin Rattus norvegicus 122-127 23919612-1 2013 A novel antihypertensive peptide (Gly-His-Ser or GHS) with dual inhibition of angiotensin I-converting enzyme (ACE) and renin activities was isolated from the 3 kDa membrane ultrafiltration permeate of a pepsin+pancreatin rapeseed protein digest. glycylhistidine 34-41 renin Rattus norvegicus 120-125 23919612-1 2013 A novel antihypertensive peptide (Gly-His-Ser or GHS) with dual inhibition of angiotensin I-converting enzyme (ACE) and renin activities was isolated from the 3 kDa membrane ultrafiltration permeate of a pepsin+pancreatin rapeseed protein digest. Serine 42-45 renin Rattus norvegicus 120-125 23919612-1 2013 A novel antihypertensive peptide (Gly-His-Ser or GHS) with dual inhibition of angiotensin I-converting enzyme (ACE) and renin activities was isolated from the 3 kDa membrane ultrafiltration permeate of a pepsin+pancreatin rapeseed protein digest. epsilon-guanidinocaproate 49-52 renin Rattus norvegicus 120-125 22483258-2 2013 We hypothesized that the AT1R antagonist losartan or the renin inhibitor aliskiren, given at doses allowing similar antihypertensive effects, could prevent in vivo vascular MMPs upregulation and remodeling, and collagen/elastin deposition found in 2K1C hypertension by preventing the activation of extracellular signal-regulated kinase 1/2 (ERK 1/2) and transforming growth factor-beta1 (TGF-beta1). aliskiren 73-82 renin Rattus norvegicus 57-62 24712284-1 2013 UNLABELLED: The renin-angiotensin system plays a crucial role in the regulation of cardiovascular function and maintenance of water-electrolyte balance. Water 126-131 renin Rattus norvegicus 16-21 23515616-0 2013 Rats with adenine-induced chronic renal failure develop low-renin, salt-sensitive hypertension and increased aortic stiffness. Adenine 10-17 renin Rattus norvegicus 60-65 23279762-10 2013 Furthermore, inhibiting the renin-angiotensin-aldosterone system using losartan, or spironolactone, prevented these deleterious effects. Losartan 71-79 renin Rattus norvegicus 28-33 23598247-0 2013 Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor. 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides 21-95 renin Rattus norvegicus 170-175 23598247-0 2013 Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor. (2r,4s,5s)-5-Amino-6-[4-(2-Chlorophenyl)-2,2-Dimethyl-5-Oxopiperazin-1-Yl]-2-Ethyl-4-Hydroxy-N-[(1r,2s,3s,5s,7s)-5-Hydroxytricyclo[3.3.1.1~3,7~]dec-2-Yl]hexanamide 143-151 renin Rattus norvegicus 170-175 23598247-2 2013 Extensive structure-activity relationships studies as well as in vivo cardiac studies using the electrophysiology rat model led to the discovery of clinical candidate trans-adamantan-1-ol analogue 56 (DS-8108b) as a potent renin inhibitor with reduced potential cardiac risk. trans-adamantan-1-ol 167-187 renin Rattus norvegicus 223-228 23598247-2 2013 Extensive structure-activity relationships studies as well as in vivo cardiac studies using the electrophysiology rat model led to the discovery of clinical candidate trans-adamantan-1-ol analogue 56 (DS-8108b) as a potent renin inhibitor with reduced potential cardiac risk. (2r,4s,5s)-5-Amino-6-[4-(2-Chlorophenyl)-2,2-Dimethyl-5-Oxopiperazin-1-Yl]-2-Ethyl-4-Hydroxy-N-[(1r,2s,3s,5s,7s)-5-Hydroxytricyclo[3.3.1.1~3,7~]dec-2-Yl]hexanamide 201-209 renin Rattus norvegicus 223-228 23771662-1 2013 This study investigated the effects of benazepril administered in the morning or evening on the diurnal variation of renin-angiotensin-aldosterone system (RAAS) and clock genes in the kidney. benazepril 39-49 renin Rattus norvegicus 117-122 23087256-1 2013 The present study was designed to investigate the potential of aliskiren, a direct renin inhibitor, in chronic constriction injury (CCI)-induced neuropathic pain in rats. aliskiren 63-72 renin Rattus norvegicus 83-88 23352204-2 2013 Thereby, we sought to determine if combination of direct renin inhibition with angiotensin type 1 receptor blockade in vivo, through greater reductions in systolic blood pressure (SBP) and aldosterone would attenuate left ventricular hypertrophy and interstitial fibrosis to a greater extent than either intervention alone. Aldosterone 189-200 renin Rattus norvegicus 57-62 23459599-5 2013 RESULTS: Antihypertensive effects of olmesartan were associated with an increase in plasma renin concentration, plasma Ang I, Ang II, and Ang-(1-7), whereas serum aldosterone levels and kidney Ang II content were reduced. olmesartan 37-47 renin Rattus norvegicus 91-96 23190689-7 2013 Plasma renin activity was significantly augmented in the valsartan-treated group, and it was significantly attenuated in the valsartan+cilnidipine-treated group. Valsartan 57-66 renin Rattus norvegicus 7-12 23322513-2 2013 In this study, we examined the changes in intrarenal renin-angiotensin system (RAS) activity in the developing kidneys of OLETF rats. oletf 122-127 renin Rattus norvegicus 53-58 23190689-7 2013 Plasma renin activity was significantly augmented in the valsartan-treated group, and it was significantly attenuated in the valsartan+cilnidipine-treated group. cilnidipine 135-146 renin Rattus norvegicus 7-12 23391983-10 2013 sodium loading evoked profound natriuresis, suppression of plasma renin activity (PRA) and global sympathoinhibition. Sodium 0-6 renin Rattus norvegicus 66-71 23060472-4 2013 This study was designed to investigate the possible protective effects of aliskiren (a direct renin inhibitor) in DXR-induced nephrotoxicity in rats. aliskiren 74-83 renin Rattus norvegicus 94-99 23425156-5 2013 The prototype analogue (3S,4S)-12a of this new class of direct renin inhibitors exerted blood pressure lowering effects in a hypertensive double-transgenic rat model after oral administration. (3s,4s)-12a 23-34 renin Rattus norvegicus 63-68 23303412-4 2013 Low-salt diet rats had markedly higher plasma renin activity and plasma ANG II levels. Salts 4-8 renin Rattus norvegicus 46-51 23377552-2 2013 In this study, we investigated whether LHTL caused physiological heart hypertrophy accompanied by changes of biomarkers in renin-angiotensin system in rats. lhtl 39-43 renin Rattus norvegicus 123-128 23002791-6 2013 A low-sodium diet increased kidney renin and liver angiotensinogen mRNA levels but not lung angiotensin-converting enzyme mRNA expression. Sodium 6-12 renin Rattus norvegicus 35-40 23060472-9 2013 CONCLUSIONS: These findings revealed that the blockade of renin activity by aliskiren is a promising approach in the treatment of DXR-induced nephrotoxicity. aliskiren 76-85 renin Rattus norvegicus 58-63 23104304-0 2013 Evaluation of enalapril affecting the renin-angiotensin system in normal and stress-induced rats based on urinary metabolites of amines and cortisol. Enalapril 14-23 renin Rattus norvegicus 38-43 23255591-6 2013 Plasma renin and angiotensin (1-7) were highest in the rats on the low-sodium diet and depressed in the rats on a high-sodium diet. Sodium 71-77 renin Rattus norvegicus 7-12 23129822-2 2013 However, it is not clear whether a low-sodium diet has beneficial effects on the development of interstitial fibrosis because it activates the renin-angiotensin-aldosterone system. Sodium 39-45 renin Rattus norvegicus 143-148 23318498-7 2013 The shortening of the action potential was related to an increase of potassium current which was measured in isolated ventricular myocytes before and after intracellular dialysis of renin (10(-9)M) using a voltage whole cell clamp configuration. Potassium 69-78 renin Rattus norvegicus 182-187 23318498-8 2013 Valsartan (10(-8)M) dialyzed together with renin (120pM) into the cell decreased drastically the effect of renin on potassium current. Valsartan 0-9 renin Rattus norvegicus 43-48 23318498-8 2013 Valsartan (10(-8)M) dialyzed together with renin (120pM) into the cell decreased drastically the effect of renin on potassium current. Valsartan 0-9 renin Rattus norvegicus 107-112 23318498-8 2013 Valsartan (10(-8)M) dialyzed together with renin (120pM) into the cell decreased drastically the effect of renin on potassium current. Potassium 116-125 renin Rattus norvegicus 43-48 23318498-8 2013 Valsartan (10(-8)M) dialyzed together with renin (120pM) into the cell decreased drastically the effect of renin on potassium current. Potassium 116-125 renin Rattus norvegicus 107-112 23318498-9 2013 An increment of potassium current was also found when intracellular renin was dialyzed into cardiomyocytes exposed to Krebs solution containing valsartan (10(-8)M) for 10min prior to renin administration. Potassium 16-25 renin Rattus norvegicus 68-73 23318498-9 2013 An increment of potassium current was also found when intracellular renin was dialyzed into cardiomyocytes exposed to Krebs solution containing valsartan (10(-8)M) for 10min prior to renin administration. Potassium 16-25 renin Rattus norvegicus 183-188 23318498-9 2013 An increment of potassium current was also found when intracellular renin was dialyzed into cardiomyocytes exposed to Krebs solution containing valsartan (10(-8)M) for 10min prior to renin administration. krebs 118-123 renin Rattus norvegicus 68-73 23318498-9 2013 An increment of potassium current was also found when intracellular renin was dialyzed into cardiomyocytes exposed to Krebs solution containing valsartan (10(-8)M) for 10min prior to renin administration. Valsartan 144-153 renin Rattus norvegicus 68-73 23318498-10 2013 Bis-1 which is a specific inhibitor of PKC, abolished the effect of intracellular renin on potassium current. 1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz(e)inden-3-yl)ethanone 0-5 renin Rattus norvegicus 82-87 23318498-10 2013 Bis-1 which is a specific inhibitor of PKC, abolished the effect of intracellular renin on potassium current. Potassium 91-100 renin Rattus norvegicus 82-87 23318498-13 2013 The effect of renin on total potassium currents was inhibited by valsartan and by Bis-1. Potassium 29-38 renin Rattus norvegicus 14-19 23318498-13 2013 The effect of renin on total potassium currents was inhibited by valsartan and by Bis-1. Valsartan 65-74 renin Rattus norvegicus 14-19 23318498-13 2013 The effect of renin on total potassium currents was inhibited by valsartan and by Bis-1. 1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz(e)inden-3-yl)ethanone 82-87 renin Rattus norvegicus 14-19 22730078-7 2013 Currently, ABP increased significantly after APAP which was mostly mediated by renal impairment and increased both renin activity and aldosterone secretion. Acetaminophen 45-49 renin Rattus norvegicus 115-120 23255591-6 2013 Plasma renin and angiotensin (1-7) were highest in the rats on the low-sodium diet and depressed in the rats on a high-sodium diet. Sodium 119-125 renin Rattus norvegicus 7-12 22895064-0 2013 Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats. Fructose 126-134 renin Rattus norvegicus 7-12 23303354-0 2013 The (pro)renin receptor blocker handle region peptide upregulates endothelium-derived contractile factors in aliskiren-treated diabetic transgenic (mREN2)27 rats. aliskiren 109-118 renin Rattus norvegicus 9-14 23213191-5 2013 In scrambled oligodeoxynucleotide-infused rats, salt loading, which did not alter blood pressure, evoked a site-specific increase in hypothalamic paraventricular nucleus Galphai(2) protein levels and suppression of circulating norepinephrine content and plasma renin activity. Salts 48-52 renin Rattus norvegicus 261-266 23213191-6 2013 In salt-loaded rats continuously infused intracerebroventricularly with a Galphai(2) oligodeoxynucleotide, animals exhibited sodium and water retention, elevated plasma norepinephrine levels, and hypertension, despite suppression of plasma renin activity. Salts 3-7 renin Rattus norvegicus 240-245 23213191-6 2013 In salt-loaded rats continuously infused intracerebroventricularly with a Galphai(2) oligodeoxynucleotide, animals exhibited sodium and water retention, elevated plasma norepinephrine levels, and hypertension, despite suppression of plasma renin activity. galphai(2) oligodeoxynucleotide 74-105 renin Rattus norvegicus 240-245 23303354-6 2013 Aliskiren normalized blood pressure, suppressed renin activity, and reversed the above vascular effects, with the exception of the altered effectiveness of ETA receptor blockade. aliskiren 0-9 renin Rattus norvegicus 48-53 24003484-3 2013 Preliminary assignment a direct renin inhibitor aliskiren enhances the diuretic, natriuretic and kaliyuretic effects of the drug. aliskiren 48-57 renin Rattus norvegicus 32-37 23174623-3 2013 Aliskiren direct renin inhibitor belongs to a new very promising antihypertensive drug that effectively inhibits the renin-angiotensin system. aliskiren 0-9 renin Rattus norvegicus 17-22 23843788-4 2013 Vitamin D has proven to be effective on renin expression, inflammatory response, oxidative stress, apoptosis, and atherosclerosis. Vitamin D 0-9 renin Rattus norvegicus 40-45 23108791-0 2013 Effect of combination of renin inhibitor and Mas-receptor agonist in DOCA-salt-induced hypertension in rats. Desoxycorticosterone Acetate 69-73 renin Rattus norvegicus 25-30 23108791-0 2013 Effect of combination of renin inhibitor and Mas-receptor agonist in DOCA-salt-induced hypertension in rats. Salts 74-78 renin Rattus norvegicus 25-30 23174623-3 2013 Aliskiren direct renin inhibitor belongs to a new very promising antihypertensive drug that effectively inhibits the renin-angiotensin system. aliskiren 0-9 renin Rattus norvegicus 117-122 22926646-4 2012 Although the renoprotective mechanism of active vitamin D in previous studies has been mainly attributed to the suppression of renin, OCT did not affect renal levels of renin or angiotensin II. Vitamin D 48-57 renin Rattus norvegicus 127-132 23122821-0 2012 Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors. (3S,5R)-5-(4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl)piperidine-3-carboxamide 28-116 renin Rattus norvegicus 127-132 23122821-1 2012 Utilizing X-ray crystal structure analysis, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides were designed and identified as renin inhibitors. (3S,5R)-5-(4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl)piperidine-3-carboxamide 44-132 renin Rattus norvegicus 165-170 22966159-8 2012 pS124-NCC levels also increased in abundance in rats after stimulation of the renin-angiotensin-aldosterone system by dietary low sodium intake. Sodium 130-136 renin Rattus norvegicus 78-83 22674025-6 2012 This agent was assessed in vitro, in vivo, and ex vivo to detect and quantify increases in plasma and kidney renin activity in sodium-sensitive inbred C57BL/6 mice maintained on a low dietary sodium and diuretic regimen. Sodium 127-133 renin Rattus norvegicus 109-114 22261625-0 2012 Chronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent hypertension. aliskiren 37-46 renin Rattus norvegicus 15-20 22261625-6 2012 In a separate group of rats (n = 6), chronic administration of the direct renin inhibitor, aliskiren (30 mg/kg/d, sc), prevented the development of hypertension (113 +- 5 versus 114 +- 5 mm Hg, not significant). aliskiren 91-100 renin Rattus norvegicus 74-79 22261625-8 2012 CONCLUSIONS: The present findings demonstrate that chronic direct renin inhibition with aliskiren prevents the development of ANG II-dependent hypertension and the associated derangements in renal hemodynamics and excretory function in Cyplal-Ren2 transgenic rats. aliskiren 88-97 renin Rattus norvegicus 66-71 23033372-9 2012 WAT injection of capsaicin increased plasma renin, angiotensin II, and norepinephrine levels in OH and caused more c-fos expression in paraventricular nucleus in OH than ON and in ON than obesity-resistant or control rats. Capsaicin 17-26 renin Rattus norvegicus 44-49 22982071-2 2012 We hypothesized that acute ethanol intake enhances vascular oxidative stress and induces vascular dysfunction through renin-angiotensin system (RAS) activation. Ethanol 27-34 renin Rattus norvegicus 118-123 22982071-7 2012 Acute ethanol intake increased plasma renin activity (PRA), angiotensin converting enzyme (ACE) activity, plasma angiotensin I (ANG I) and angiotensin II (ANG II) levels. Ethanol 6-13 renin Rattus norvegicus 38-43 23089401-2 2012 However, aliskiren attenuates the effect of Ang II through direct renin inhibition. aliskiren 9-18 renin Rattus norvegicus 66-71 22649069-0 2012 Parathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake. Sodium Chloride 97-112 renin Rattus norvegicus 54-59 22649069-3 2012 We hypothesized that chronically elevated PTHrP would increase plasma renin activity (PRA) indirectly via its anorexic effects, reducing sodium chloride (NaCl) intake and causing NaCl restriction. Sodium Chloride 137-152 renin Rattus norvegicus 70-75 22649069-3 2012 We hypothesized that chronically elevated PTHrP would increase plasma renin activity (PRA) indirectly via its anorexic effects, reducing sodium chloride (NaCl) intake and causing NaCl restriction. Sodium Chloride 154-158 renin Rattus norvegicus 70-75 22649069-3 2012 We hypothesized that chronically elevated PTHrP would increase plasma renin activity (PRA) indirectly via its anorexic effects, reducing sodium chloride (NaCl) intake and causing NaCl restriction. Sodium Chloride 179-183 renin Rattus norvegicus 70-75 22592638-1 2012 High sodium intake is known to regulate the renal renin-angiotensin system (RAS) and is a risk factor for the pathogenesis of obesity-related hypertension. Sodium 5-11 renin Rattus norvegicus 50-55 22723444-0 2012 Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 104-135 renin Rattus norvegicus 65-70 22723444-2 2012 Moreover, 20-HETE-dependent vascular dysfunction and hypertension are associated with upregulation of the renin-angiotensin system This study was undertaken to examine the contribution of renin-angiotensin system to 20-HETE actions in the vascular endothelium. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 10-17 renin Rattus norvegicus 106-111 22723444-2 2012 Moreover, 20-HETE-dependent vascular dysfunction and hypertension are associated with upregulation of the renin-angiotensin system This study was undertaken to examine the contribution of renin-angiotensin system to 20-HETE actions in the vascular endothelium. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 216-223 renin Rattus norvegicus 188-193 21937213-0 2012 Role of the renin-angiotensin-aldosterone system in the enhancement of salt sensitivity caused by prenatal protein restriction in stroke-prone spontaneously hypertensive rats. Salts 71-75 renin Rattus norvegicus 12-17 22710644-10 2012 Concomitant oral administration of RB150 with a systemic renin-angiotensin system blocker, enalapril, potentiated the RB150-induced blood pressure decrease achieved in <2 hours. firibastat 35-40 renin Rattus norvegicus 57-62 22710644-10 2012 Concomitant oral administration of RB150 with a systemic renin-angiotensin system blocker, enalapril, potentiated the RB150-induced blood pressure decrease achieved in <2 hours. Enalapril 91-100 renin Rattus norvegicus 57-62 22710644-10 2012 Concomitant oral administration of RB150 with a systemic renin-angiotensin system blocker, enalapril, potentiated the RB150-induced blood pressure decrease achieved in <2 hours. firibastat 118-123 renin Rattus norvegicus 57-62 22710644-11 2012 Thus, RB150 may be the prototype of a new class of centrally active antihypertensive agents that might be used in combination with classic systemic renin-angiotensin system blockers to improve blood pressure control. firibastat 6-11 renin Rattus norvegicus 148-153 22224457-5 2012 EXPERIMENTAL APPROACH: Depressor responses to renin microinjected into the NTS of Wistar-Kyoto rats were elicited in the absence and presence of the endothelial nitric oxide synthase (eNOS)-specific inhibitor, N(5)-(-iminoethyl)-L-ornithine, Akt inhibitor IV and LY294002, a PI3K inhibitor and GP antagonist-2A [G(q) inhibitor]. 8-dehydroxythienamycin 210-214 renin Rattus norvegicus 46-51 22224457-5 2012 EXPERIMENTAL APPROACH: Depressor responses to renin microinjected into the NTS of Wistar-Kyoto rats were elicited in the absence and presence of the endothelial nitric oxide synthase (eNOS)-specific inhibitor, N(5)-(-iminoethyl)-L-ornithine, Akt inhibitor IV and LY294002, a PI3K inhibitor and GP antagonist-2A [G(q) inhibitor]. (-iminoethyl)-l-ornithine 215-240 renin Rattus norvegicus 46-51 22224457-5 2012 EXPERIMENTAL APPROACH: Depressor responses to renin microinjected into the NTS of Wistar-Kyoto rats were elicited in the absence and presence of the endothelial nitric oxide synthase (eNOS)-specific inhibitor, N(5)-(-iminoethyl)-L-ornithine, Akt inhibitor IV and LY294002, a PI3K inhibitor and GP antagonist-2A [G(q) inhibitor]. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 263-271 renin Rattus norvegicus 46-51 22224457-9 2012 Immunoblotting and immunohistochemical studies further showed that inhibition of PI3K significantly blocked renin-induced eNOS-Ser 117 and Akt-Ser473 phosphorylation in situ. Serine 127-130 renin Rattus norvegicus 108-113 22728903-8 2012 Lisinopril decreased their SBP (-23 vs. -13 mmHg in controls), kidney Ang-II/I (~3-fold vs. ~2-fold) and Ile(5)-Ang-II (-70 vs. -40%), and increased kidney renin and Ile(5)-Ang-I (>2.5-fold vs. <2.5-fold). Lisinopril 0-10 renin Rattus norvegicus 156-161 21937213-2 2012 The present study was conducted to investigate the participation of the renin-angiotensin-aldosterone system in the development of salt sensitivity in the offspring of dams fed a low-protein diet during pregnancy. Salts 131-135 renin Rattus norvegicus 72-77 22542773-0 2012 The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. Pilocarpine 104-115 renin Rattus norvegicus 14-19 22609375-0 2012 Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons. aliskiren 16-25 renin Rattus norvegicus 0-5 22609375-2 2012 Renin-angiotensin system (RAS) blockers, including the renin inhibitor aliskiren, are a group of clinically relevant anti-hypertensive agents. aliskiren 71-80 renin Rattus norvegicus 0-5 22609375-2 2012 Renin-angiotensin system (RAS) blockers, including the renin inhibitor aliskiren, are a group of clinically relevant anti-hypertensive agents. aliskiren 71-80 renin Rattus norvegicus 55-60 22609375-6 2012 Notably, aliskiren blocked Abeta-mediated neuronal induction of renin. aliskiren 9-18 renin Rattus norvegicus 64-69 21989861-10 2012 Our results suggest that the L/N-type calcium channel blocker cilnidipine reduces the plasma aldosterone level by suppressing the aldosterone production induced by reflex upregulation of the renin-angiotensin-aldosterone system associated with reduction of the blood pressure. cilnidipine 62-73 renin Rattus norvegicus 191-196 21989861-10 2012 Our results suggest that the L/N-type calcium channel blocker cilnidipine reduces the plasma aldosterone level by suppressing the aldosterone production induced by reflex upregulation of the renin-angiotensin-aldosterone system associated with reduction of the blood pressure. Aldosterone 130-141 renin Rattus norvegicus 191-196 22031275-11 2012 Myocardial renin and angiotensin II messenger RNA (mRNA) in HF group was also higher when compared with the control and pioglitazone groups, whereas the expression of AT2 mRNA was lower (P < .01). Pioglitazone 120-132 renin Rattus norvegicus 11-35 22465166-0 2012 Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat. Aldosterone 90-101 renin Rattus norvegicus 22-27 22383697-10 2012 CONCLUSIONS: Chronic salt overload in Dahl-S rats stimulates aberrant aldosterone production via activation of the local renin-angiotensin system in the adrenal gland, thereby creating the comorbidity of excess salt and elevated plasma aldosterone. Salts 21-25 renin Rattus norvegicus 121-126 22521760-0 2012 Maternal high-sodium intake alters the responsiveness of the renin-angiotensin system in adult offspring. Sodium 14-20 renin Rattus norvegicus 61-66 22521760-1 2012 AIMS: The goal of the current study was to evaluate the impact of maternal sodium intake during gestation on the systemic and renal renin-angiotensin-aldosterone-system (RAAS) of the adult offspring. Sodium 75-81 renin Rattus norvegicus 132-137 22383697-5 2012 The late rise in aldosterone biosynthesis was accompanied by upregulation of CYP11B2 expression in the zona glomerulosa and increased adrenal angiotensin II levels and renin-angiotensin system components. Aldosterone 17-28 renin Rattus norvegicus 168-173 22383697-10 2012 CONCLUSIONS: Chronic salt overload in Dahl-S rats stimulates aberrant aldosterone production via activation of the local renin-angiotensin system in the adrenal gland, thereby creating the comorbidity of excess salt and elevated plasma aldosterone. Salts 211-215 renin Rattus norvegicus 121-126 22383697-10 2012 CONCLUSIONS: Chronic salt overload in Dahl-S rats stimulates aberrant aldosterone production via activation of the local renin-angiotensin system in the adrenal gland, thereby creating the comorbidity of excess salt and elevated plasma aldosterone. Aldosterone 70-81 renin Rattus norvegicus 121-126 22642589-1 2012 The objective of our study was to investigate the effect of Aliskiren, a renin inhibitor, on the deoxycorticosterone (DOCA) induced myocardial fibrosis in a rat model and its underlying mechanism. aliskiren 60-69 renin Rattus norvegicus 73-78 22642589-1 2012 The objective of our study was to investigate the effect of Aliskiren, a renin inhibitor, on the deoxycorticosterone (DOCA) induced myocardial fibrosis in a rat model and its underlying mechanism. Desoxycorticosterone 97-116 renin Rattus norvegicus 73-78 22642589-1 2012 The objective of our study was to investigate the effect of Aliskiren, a renin inhibitor, on the deoxycorticosterone (DOCA) induced myocardial fibrosis in a rat model and its underlying mechanism. Desoxycorticosterone Acetate 118-122 renin Rattus norvegicus 73-78 22160776-5 2012 In contrast, plasma renin activity was lowered in rats with MI+NX. nx 63-65 renin Rattus norvegicus 20-25 22262304-3 2012 Intracerebroventricular infusion of aliskiren at the rate of 0.05 mg/day markedly inhibited the increase in ANG II levels in the cerebrospinal fluid and in blood pressure (BP) caused by intracerebroventricular infusion of rat renin. aliskiren 36-45 renin Rattus norvegicus 226-231 22262304-9 2012 These results indicate that intracerebroventricular infusions of aliskiren and an AT(1) receptor blocker are similarly effective in preventing salt-induced sympathetic hyperactivity and hypertension in Dahl S rats, suggesting that renin in the brain plays an essential role in the salt-induced hypertension. aliskiren 65-74 renin Rattus norvegicus 231-236 22325946-0 2012 3,4-Diarylpiperidines as potent renin inhibitors. 3,4-diarylpiperidines 0-21 renin Rattus norvegicus 32-37 22325946-1 2012 The discovery and SAR of a series of potent renin inhibitors possessing a novel 3,4-diarylpiperidine scaffold are described herein. 3,4-diarylpiperidine 80-100 renin Rattus norvegicus 44-49 21940660-4 2012 We continued to study whether H(2)S may mediate cAMP-dependent renin degranulaion in As4.1 cells. Hydrogen Sulfide 30-35 renin Rattus norvegicus 63-68 22803141-5 2012 The more pronounced effect of quinapril both under anesthesia and during immobilization appears to be linked to the highest affinity of quinaprilat to circulatory and tissue compartments of the renin-angiotensin-aldosterone system. Quinapril 30-39 renin Rattus norvegicus 194-199 22803141-5 2012 The more pronounced effect of quinapril both under anesthesia and during immobilization appears to be linked to the highest affinity of quinaprilat to circulatory and tissue compartments of the renin-angiotensin-aldosterone system. quinaprilat 136-147 renin Rattus norvegicus 194-199 22248199-0 2012 Effects of renin-angiotensin-aldosterone system blockade on chlorhexidine gluconate-induced sclerosing encapsulated peritonitis in rats. chlorhexidine gluconate 60-83 renin Rattus norvegicus 11-16 21940660-0 2012 Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells. Hydrogen Sulfide 0-16 renin Rattus norvegicus 48-53 21940660-0 2012 Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells. Hydrogen Sulfide 0-16 renin Rattus norvegicus 85-90 21940660-1 2012 The present study aims to investigate the regulatory effect of hydrogen sulfide (H(2)S) on cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells. Hydrogen Sulfide 63-79 renin Rattus norvegicus 149-154 22075749-1 2012 We hypothesized that compared with hydrochlorothiazide (HCTZ), the renin inhibitor aliskiren (ALISK) or amlodipine (AMLO) and their combination reduce albuminuria via reduction in renal inflammation, independent of blood pressure (BP) changes. aliskiren 83-92 renin Rattus norvegicus 67-72 22075749-1 2012 We hypothesized that compared with hydrochlorothiazide (HCTZ), the renin inhibitor aliskiren (ALISK) or amlodipine (AMLO) and their combination reduce albuminuria via reduction in renal inflammation, independent of blood pressure (BP) changes. aliskiren 94-99 renin Rattus norvegicus 67-72 22493605-4 2012 This lean model of hypertension, insulin resistance and oxidative stress harbors the mouse renin gene with increased local tissue (aortic) levels of angiotensin II and angiotensin type 1 receptors and elevated plasma aldosterone levels. Aldosterone 217-228 renin Rattus norvegicus 91-96 22517117-1 2012 BACKGROUND: Vitamin D receptor activation with paricalcitol can modulate the transcription of renin-angiotensin system components in the surgical 5/6 nephrectomy rat model (5/6 NX) of chronic renal insufficiency. paricalcitol 47-59 renin Rattus norvegicus 94-99 22517117-2 2012 We tested the hypothesis whether dietary modification of phosphate influences kidney renin-angiotensin system gene expression at the mRNA level in 5/6 NX rats. Phosphates 57-66 renin Rattus norvegicus 85-90 21940660-1 2012 The present study aims to investigate the regulatory effect of hydrogen sulfide (H(2)S) on cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells. Hydrogen Sulfide 81-86 renin Rattus norvegicus 149-154 21940660-4 2012 We continued to study whether H(2)S may mediate cAMP-dependent renin degranulaion in As4.1 cells. Cyclic AMP 48-52 renin Rattus norvegicus 63-68 21940660-5 2012 It was found that NaHS at 0.1-10 muM significantly increased intracellular renin protein level. sodium bisulfide 18-22 renin Rattus norvegicus 75-80 21993885-5 2012 Male Cyp1a1-Ren2 transgenic rats were induced to develop malignant hypertension, anesthetized, and surgically prepared for intrarenal administration of the direct renin inhibitor aliskiren (0.01 mg/kg). aliskiren 179-188 renin Rattus norvegicus 163-168 21940660-6 2012 Moreover, NaHS reversed the declined renin content within As4.1 cells and normalized the upregulated renin activity in the culture medium of As4.1 cells treated with the above three stimuli. sodium bisulfide 10-14 renin Rattus norvegicus 37-42 21998138-1 2012 Focus on "Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cell". Hydrogen Sulfide 10-26 renin Rattus norvegicus 58-63 21940660-6 2012 Moreover, NaHS reversed the declined renin content within As4.1 cells and normalized the upregulated renin activity in the culture medium of As4.1 cells treated with the above three stimuli. sodium bisulfide 10-14 renin Rattus norvegicus 101-106 21998138-1 2012 Focus on "Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cell". Hydrogen Sulfide 10-26 renin Rattus norvegicus 95-100 21998138-1 2012 Focus on "Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cell". Cyclic AMP 37-41 renin Rattus norvegicus 95-100 22049232-0 2012 Chronic renin inhibition with aliskiren improves glucose tolerance, insulin sensitivity, and skeletal muscle glucose transport activity in obese Zucker rats. Glucose 49-56 renin Rattus norvegicus 8-13 21940660-8 2012 Overexpression of cystathionine-gamma-lyase increased endogenous H(2)S production and suppressed isoproterenol-induced renin release, suggesting that endogenous H(2)S may also inhibit renin release from As4.1 cells. Isoproterenol 97-110 renin Rattus norvegicus 119-124 22049232-6 2012 Renin inhibition was associated with a significant lowering (10%, P < 0.05) of resting systolic blood pressure and induced reductions in fasting plasma glucose (11%) and free fatty acids (46%) and homeostatic model assessment for insulin resistance (13%). Glucose 155-162 renin Rattus norvegicus 0-5 22049232-6 2012 Renin inhibition was associated with a significant lowering (10%, P < 0.05) of resting systolic blood pressure and induced reductions in fasting plasma glucose (11%) and free fatty acids (46%) and homeostatic model assessment for insulin resistance (13%). Fatty Acids, Nonesterified 173-189 renin Rattus norvegicus 0-5 21940660-8 2012 Overexpression of cystathionine-gamma-lyase increased endogenous H(2)S production and suppressed isoproterenol-induced renin release, suggesting that endogenous H(2)S may also inhibit renin release from As4.1 cells. Hydrogen Sulfide 161-166 renin Rattus norvegicus 184-189 22049232-7 2012 Glucose tolerance (glucose area under the curve) and whole body insulin sensitivity (inverse of the glucose-insulin index) during an oral glucose tolerance test were improved by 15% and 16%, respectively, following chronic renin inhibition. Glucose 19-26 renin Rattus norvegicus 223-228 21940660-9 2012 We also tested whether H(2)S has a similar effect in renin-rich kidney cells. Hydrogen Sulfide 23-28 renin Rattus norvegicus 53-58 22049232-7 2012 Glucose tolerance (glucose area under the curve) and whole body insulin sensitivity (inverse of the glucose-insulin index) during an oral glucose tolerance test were improved by 15% and 16%, respectively, following chronic renin inhibition. Glucose 100-107 renin Rattus norvegicus 223-228 21940660-10 2012 It was found that isoproterenol elevated intracellular cAMP level and extracellular renin activity but decreased renin protein level in the renin-rich kidney cells. Isoproterenol 18-31 renin Rattus norvegicus 84-89 22049232-8 2012 Moreover, insulin-stimulated glucose transport activity in isolated soleus muscle of renin inhibitor-treated animals was increased by 36% and was associated with a 2.2-fold greater Akt Ser(473) phosphorylation. Glucose 29-36 renin Rattus norvegicus 85-90 21940660-10 2012 It was found that isoproterenol elevated intracellular cAMP level and extracellular renin activity but decreased renin protein level in the renin-rich kidney cells. Isoproterenol 18-31 renin Rattus norvegicus 113-118 22049232-8 2012 Moreover, insulin-stimulated glucose transport activity in isolated soleus muscle of renin inhibitor-treated animals was increased by 36% and was associated with a 2.2-fold greater Akt Ser(473) phosphorylation. Serine 185-188 renin Rattus norvegicus 85-90 22049232-9 2012 These data provide evidence that chronic selective inhibition of renin activity leads to improvements in glucose tolerance and whole body insulin sensitivity in the insulin-resistant obese Zucker rat. Glucose 105-112 renin Rattus norvegicus 65-70 21940660-10 2012 It was found that isoproterenol elevated intracellular cAMP level and extracellular renin activity but decreased renin protein level in the renin-rich kidney cells. Isoproterenol 18-31 renin Rattus norvegicus 113-118 22049232-10 2012 Importantly, chronic renin inhibition is associated with upregulation of insulin action on skeletal muscle glucose transport, and it may involve improved Akt signaling. Glucose 107-114 renin Rattus norvegicus 21-26 21940660-13 2012 Our findings suggest that H(2)S plays a critical role in regulation of renin degranulation in As4.1 and rat renin-rich kidney cells. Hydrogen Sulfide 26-31 renin Rattus norvegicus 71-76 21940660-13 2012 Our findings suggest that H(2)S plays a critical role in regulation of renin degranulation in As4.1 and rat renin-rich kidney cells. Hydrogen Sulfide 26-31 renin Rattus norvegicus 108-113 22189567-10 2012 Interestingly, treatment with the angiotensin type-1 receptor antagonist candesartan led to remarkable reduction in renin-angiotensin system activity and dopaminergic neuron loss in both groups of menopausal rats. candesartan 73-84 renin Rattus norvegicus 116-121 22613984-2 2012 This study elucidates the possible contribution of mitochondria to the anti-hypertrophic effects of the direct renin inhibitor aliskiren in post-infarction heart failure complicated with diabetes in rats. aliskiren 127-136 renin Rattus norvegicus 111-116 23197974-0 2012 Blockade of renin angiotensin system increased resistance to STZ-induced diabetes in rats with long-term high-fat diet. Streptozocin 61-64 renin Rattus norvegicus 12-17 22455940-1 2012 OBJECTIVE: To Investigate the influences of chronic intermittent hypoxia (CIH) and continuous hypoxia (CH) on renin angiotensin system (RAS) in serum and tissues of rats, and therefore to investigate the mechanism of CIH-induced hypertension and hypoxia induced pulmonary hypertension. cih 74-77 renin Rattus norvegicus 110-115 22236548-4 2012 Additionally, we showed that 27-OH and 24(S)-hydroxycholesterol (24S-OH) enhance AGT synthesis and modulate renin and ACE activities in brain cells. 27-hydroxycholesterol 29-34 renin Rattus norvegicus 108-113 22236548-4 2012 Additionally, we showed that 27-OH and 24(S)-hydroxycholesterol (24S-OH) enhance AGT synthesis and modulate renin and ACE activities in brain cells. 24-hydroxycholesterol 39-63 renin Rattus norvegicus 108-113 22236548-4 2012 Additionally, we showed that 27-OH and 24(S)-hydroxycholesterol (24S-OH) enhance AGT synthesis and modulate renin and ACE activities in brain cells. 24-hydroxycholesterol 65-71 renin Rattus norvegicus 108-113 21500184-11 2012 CONCLUSION: Compared with transplantation to the OM, transplantation of rat metanephroi to the PA results in better renin production, whereas the transplantation site does not affect EPO production. Protactinium 95-97 renin Rattus norvegicus 116-121 22677784-0 2012 Effect of the direct renin inhibitor aliskiren in the prevention of experimental contrast-induced nephropathy in the rat. aliskiren 37-46 renin Rattus norvegicus 21-26 22677784-2 2012 The purpose of this study was to evaluate the effect of aliskiren, a direct renin inhibitor, for the prophylaxis of experimental CIN in the rat. aliskiren 56-65 renin Rattus norvegicus 76-81 21865264-1 2011 Renin expression in principal cells of collecting ducts (CD) is upregulated in angiotensin II (ANG II)-dependent hypertensive rats; however, it remains unclear whether increased CD-derived renin undergoes tubular secretion. Cadmium 57-59 renin Rattus norvegicus 0-5 21865264-10 2011 Thus, in ANG II-dependent hypertensive rats with marked PRA suppression, increased urinary levels of renin and prorenin reflect their augmented secretion by CD cells into the luminal fluid. Cadmium 157-159 renin Rattus norvegicus 101-106 22020141-4 2011 The genetic locus and potential role of the renin gene in mediating vascular smooth muscle sensitivity to propofol were determined in three selected subcongenic SS.BN13 strains. Propofol 106-114 renin Rattus norvegicus 44-49 21865264-11 2011 The greater availability of renin and AGT in the urine reflects the capability for intratubular ANG II formation which stimulates sodium reabsorption in distal nephron segments. Sodium 130-136 renin Rattus norvegicus 28-33 22020141-7 2011 Using subcongenics, the increased propofol-induced cardiovascular sensitivity and hyperpolarization was further localized to an eight-gene region (containing the BN renin gene). Propofol 34-42 renin Rattus norvegicus 165-170 22020141-9 2011 CONCLUSIONS: Enhanced cardiovascular sensitivity to propofol in SS (compared with BN) is caused by an altered renin gene. Propofol 52-60 renin Rattus norvegicus 110-115 21946111-3 2011 We tested whether the development of hypertension and the increases in ADMA in spontaneously hypertensive rats (SHR) are prevented by aliskiren, a renin inhibitor. aliskiren 134-143 renin Rattus norvegicus 147-152 21885994-3 2011 Compared with vehicle (olive oil)-treated rats, chronic treatment with CSA (20 mg kg d subcutaneous, for 14 days) increased systolic blood pressure, elevated renal function indices and plasma renin activity, impaired renovascular responsiveness of isolated perfused rat kidneys to endothelium-dependent vasodilations induced by carbachol. Cyclosporine 71-74 renin Rattus norvegicus 192-197 21824999-0 2011 Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone. Aldosterone 76-87 renin Rattus norvegicus 27-32 22291836-2 2011 The objective of this study was to examine the effects of aliskiren, a direct renin inhibitor, on the metabolic syndrome of fructose-fed rats. aliskiren 58-67 renin Rattus norvegicus 78-83 21956196-4 2011 METHODS: Using a Fischer-to-Lewis renal transplantation model, the effect of the renin inhibitor aliskiren (10 mg/kg/day) was assessed on the development of chronic allograft dysfunction compared with vehicle treatment and Ang II receptor blockers candesartan. aliskiren 97-106 renin Rattus norvegicus 81-86 21956196-9 2011 CONCLUSIONS: The renin inhibitor aliskiren does not slow the progression of chronic allograft dysfunction. aliskiren 33-42 renin Rattus norvegicus 17-22 22050062-6 2011 NEB plus HCTZ was associated with reduced oxidative stress in terms of glutathione availability, lower angiotensin I levels as index of plasma renin activity and reduced clearance of urinary sodium compared with HCTZ alone. Nebivolol 0-3 renin Rattus norvegicus 143-148 22050062-6 2011 NEB plus HCTZ was associated with reduced oxidative stress in terms of glutathione availability, lower angiotensin I levels as index of plasma renin activity and reduced clearance of urinary sodium compared with HCTZ alone. Hydrochlorothiazide 9-13 renin Rattus norvegicus 143-148 21755314-1 2011 AIM/HYPOTHESIS: We examined whether the renin inhibitor, aliskiren, provides similar or greater protection than ACE inhibition from non-proliferative diabetic retinopathy and from the proliferative neoangiogenesis of oxygen-induced retinopathy. aliskiren 57-66 renin Rattus norvegicus 40-45 21846804-0 2011 Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels. Arachidonic Acid 31-47 renin Rattus norvegicus 14-19 21846804-0 2011 Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels. 12-HPETE 61-72 renin Rattus norvegicus 14-19 21846804-0 2011 Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 77-84 renin Rattus norvegicus 14-19 21846804-1 2011 We test the hypothesis that 12-hydroperoxyeicosatetraenoic acid (12(s)-HPETE) and 12-hydroxyeicosatetraenoic acid (12-HETE) perfused into the renal pelvis increase afferent renal nerve activity (ARNA) and suppress renin release in rats fed a low-salt (LS) diet via activation of the transient receptor potential vanilloid type 1 (TRPV1) expressed in renal sensory nerves. 12-HPETE 28-63 renin Rattus norvegicus 214-219 21846804-1 2011 We test the hypothesis that 12-hydroperoxyeicosatetraenoic acid (12(s)-HPETE) and 12-hydroxyeicosatetraenoic acid (12-HETE) perfused into the renal pelvis increase afferent renal nerve activity (ARNA) and suppress renin release in rats fed a low-salt (LS) diet via activation of the transient receptor potential vanilloid type 1 (TRPV1) expressed in renal sensory nerves. 12-HPETE 65-76 renin Rattus norvegicus 214-219 21846804-1 2011 We test the hypothesis that 12-hydroperoxyeicosatetraenoic acid (12(s)-HPETE) and 12-hydroxyeicosatetraenoic acid (12-HETE) perfused into the renal pelvis increase afferent renal nerve activity (ARNA) and suppress renin release in rats fed a low-salt (LS) diet via activation of the transient receptor potential vanilloid type 1 (TRPV1) expressed in renal sensory nerves. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 82-113 renin Rattus norvegicus 214-219 21859963-3 2011 Thrombin dose-dependently reduced perfusate flow and inhibited renin secretion rates (RSRs) that had been prestimulated by the beta-adrenoreceptor agonist isoproterenol. Isoproterenol 155-168 renin Rattus norvegicus 63-68 21825222-0 2011 Hypercalcemia reduces plasma renin via parathyroid hormone, renal interstitial calcium, and the calcium-sensing receptor. Calcium 79-86 renin Rattus norvegicus 29-34 21736602-2 2011 Aliskiren is a renin inhibitor with an IC(50) of 0.6 nmol/L for human renin, 4.5 nmol/L for mouse renin and 80 nmol/L for rat renin. aliskiren 0-9 renin Rattus norvegicus 70-75 21784634-0 2011 Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents. piperidine 103-113 renin Rattus norvegicus 120-125 21736602-2 2011 Aliskiren is a renin inhibitor with an IC(50) of 0.6 nmol/L for human renin, 4.5 nmol/L for mouse renin and 80 nmol/L for rat renin. aliskiren 0-9 renin Rattus norvegicus 70-75 21736602-2 2011 Aliskiren is a renin inhibitor with an IC(50) of 0.6 nmol/L for human renin, 4.5 nmol/L for mouse renin and 80 nmol/L for rat renin. aliskiren 0-9 renin Rattus norvegicus 70-75 21521778-1 2011 Impaired regulation of renin in Dahl salt-sensitive rats (SS/JRHsdMcwi, SS) contributes to attenuated angiogenesis in this strain. Salts 37-41 renin Rattus norvegicus 23-28 21640714-1 2011 PURPOSE: We investigated whether the direct renin inhibitor aliskiren can affect metabolism in cardiomyocytes from rat, mouse and human sources. aliskiren 60-69 renin Rattus norvegicus 44-49 21421651-8 2011 CONCLUSIONS: Addition of the telmisartan to trandolapril was more effective in reducing renal structural changes and improvement of renal function than monotherapy with either drug, possibly due to dual inhibitory effect on the renin- angiotensin system, and thus suppression of TGF-beta1, TNF-alpha. Telmisartan 29-40 renin Rattus norvegicus 228-233 21421651-8 2011 CONCLUSIONS: Addition of the telmisartan to trandolapril was more effective in reducing renal structural changes and improvement of renal function than monotherapy with either drug, possibly due to dual inhibitory effect on the renin- angiotensin system, and thus suppression of TGF-beta1, TNF-alpha. trandolapril 44-56 renin Rattus norvegicus 228-233 21720266-2 2011 METHODS: Hypertension was induced in Cyp1a1-Ren-2 rats through dietary administration for 11 days of the natural xenobiotic indole-3-carbinol (I3C) which activates the renin gene. indole-3-carbinol 124-141 renin Rattus norvegicus 168-173 21720266-2 2011 METHODS: Hypertension was induced in Cyp1a1-Ren-2 rats through dietary administration for 11 days of the natural xenobiotic indole-3-carbinol (I3C) which activates the renin gene. indole-3-carbinol 143-146 renin Rattus norvegicus 168-173 21393355-3 2011 MATERIALS AND METHODS: The effect of renin-angiotensin system blockers on blood pressure was determined with adult dTG rats treated with enalapril from 3 to 12 weeks of age. 1-(4-azido-2-methylphenyl)-3-(2-methylphenyl)guanidine 115-118 renin Rattus norvegicus 37-42 21959517-7 2011 RESULTS: The perfusion with UW and EC solution caused an increase of renin I, angiotensinogen and angiotensin I-converting enzyme genes expression in kidneys. ec 35-37 renin Rattus norvegicus 69-74 21537151-10 2011 Plasma renin activity and angiotensin concentrations were lower in Cas, FC and FTC (groups with testosterone absent or blocked) than in controls and TC (groups with testosterone intact). Technetium 80-82 renin Rattus norvegicus 7-12 21537151-12 2011 CONCLUSIONS: In salt-loaded rats, testosterone seems to activate the renin-angiotensin system, resulting in sodium retention, higher BP and renal injury. Salts 16-20 renin Rattus norvegicus 69-74 21537151-12 2011 CONCLUSIONS: In salt-loaded rats, testosterone seems to activate the renin-angiotensin system, resulting in sodium retention, higher BP and renal injury. Testosterone 34-46 renin Rattus norvegicus 69-74 21537151-12 2011 CONCLUSIONS: In salt-loaded rats, testosterone seems to activate the renin-angiotensin system, resulting in sodium retention, higher BP and renal injury. Sodium 108-114 renin Rattus norvegicus 69-74 21307363-5 2011 In some rats, levels of renin and aldosterone secretion in response to isoproterenol or salbutamol were measured in additional tests. Isoproterenol 71-84 renin Rattus norvegicus 24-29 21543638-2 2011 CIH has been linked to persistent activation of arterial chemoreceptors and the renin-angiotensin system, which have been linked to chronic elevations of sympathetic nerve activity (SNA) and mean arterial pressure (MAP). cih 0-3 renin Rattus norvegicus 80-85 21331057-10 2011 CONCLUSIONS: These findings suggest that introgressing the BN renin allele onto the Dahl SS genetic background to restore normal activity of the renin-angiotensin system (RAS) protects NO-dependent vascular relaxation in cerebral arteries by increasing the expression of Cu/Zn SOD and lowering vascular superoxide levels. Superoxides 303-313 renin Rattus norvegicus 62-67 21331057-10 2011 CONCLUSIONS: These findings suggest that introgressing the BN renin allele onto the Dahl SS genetic background to restore normal activity of the renin-angiotensin system (RAS) protects NO-dependent vascular relaxation in cerebral arteries by increasing the expression of Cu/Zn SOD and lowering vascular superoxide levels. Superoxides 303-313 renin Rattus norvegicus 145-150 21358304-3 2011 This study was performed to determine the effects of acute direct renin inhibition with aliskiren on blood pressure and renal hemodynamics in Cyp1a1-Ren2 rats with ANG II-dependent malignant hypertension. aliskiren 88-97 renin Rattus norvegicus 66-71 21331057-0 2011 Introgression of the Brown Norway renin allele onto the Dahl salt-sensitive genetic background increases Cu/Zn SOD expression in cerebral arteries. dahl salt 56-65 renin Rattus norvegicus 34-39 21331057-1 2011 BACKGROUND: Nitric oxide (NO)-dependent vasodilation is impaired in middle cerebral arteries (MCAs) from Dahl salt-sensitive (SS) rats that are fed normal salt (NS) diet, due to low plasma renin activity and chronic exposure to low plasma angiotensin II (ANG II) levels. Nitric Oxide 12-24 renin Rattus norvegicus 189-194 21307363-5 2011 In some rats, levels of renin and aldosterone secretion in response to isoproterenol or salbutamol were measured in additional tests. Albuterol 88-98 renin Rattus norvegicus 24-29 21307363-9 2011 Renin secretion after isoproterenol and salbutamol was greater in young rats than in middle-aged rats, and wholly absent in old rats. Isoproterenol 22-35 renin Rattus norvegicus 0-5 21307363-9 2011 Renin secretion after isoproterenol and salbutamol was greater in young rats than in middle-aged rats, and wholly absent in old rats. Albuterol 40-50 renin Rattus norvegicus 0-5 21242461-6 2011 Blood urea nitrogen (BUN) and plasma creatinine levels were elevated in the Ren-/- strain (BUN 112 +- 7 versus 23 +- 2 mg/dL and creatinine 0.53 +- 0.02 versus 0.26 +- 0.02 mg/dL), and kidney morphology was abnormal with a rudimentary inner renal medulla, cortical interstitial fibrosis, thickening of arterial walls, and abnormally shaped glomeruli. Urea 6-10 renin Rattus norvegicus 76-79 22235383-1 2011 Adaptation to high-altitude conditions in rats with experimental renal failure is associated with shifts in the rennin-angiotensin-aldosterone system, which manifested in different serum levels of renin and aldosterone in response to water and salt loads depending on the stage of the compensation processes. Water 234-239 renin Rattus norvegicus 197-202 22235383-1 2011 Adaptation to high-altitude conditions in rats with experimental renal failure is associated with shifts in the rennin-angiotensin-aldosterone system, which manifested in different serum levels of renin and aldosterone in response to water and salt loads depending on the stage of the compensation processes. Salts 244-248 renin Rattus norvegicus 197-202 21321303-0 2011 Handle region peptide counteracts the beneficial effects of the Renin inhibitor aliskiren in spontaneously hypertensive rats. aliskiren 80-89 renin Rattus norvegicus 64-69 20947539-1 2011 BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) activation plays an important role in cyclosporine (CsA)-induced nephropathy. Cyclosporine 94-106 renin Rattus norvegicus 12-17 20947539-1 2011 BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) activation plays an important role in cyclosporine (CsA)-induced nephropathy. Cyclosporine 108-111 renin Rattus norvegicus 12-17 20947539-5 2011 Biochemical analysis showed that the plasma renin activity (PRA) and serum concentration of aldosterone were significantly increased in the CsA group compared with the control group and significantly decreased in the CsA-GTE group compared with the CsA group. Cyclosporine 140-143 renin Rattus norvegicus 44-49 20947539-5 2011 Biochemical analysis showed that the plasma renin activity (PRA) and serum concentration of aldosterone were significantly increased in the CsA group compared with the control group and significantly decreased in the CsA-GTE group compared with the CsA group. Cyclosporine 217-220 renin Rattus norvegicus 44-49 20947539-5 2011 Biochemical analysis showed that the plasma renin activity (PRA) and serum concentration of aldosterone were significantly increased in the CsA group compared with the control group and significantly decreased in the CsA-GTE group compared with the CsA group. gte 221-224 renin Rattus norvegicus 44-49 20947539-5 2011 Biochemical analysis showed that the plasma renin activity (PRA) and serum concentration of aldosterone were significantly increased in the CsA group compared with the control group and significantly decreased in the CsA-GTE group compared with the CsA group. Cyclosporine 217-220 renin Rattus norvegicus 44-49 20947539-6 2011 The total level of renin protein expression was significantly higher in the CsA group than in the control group, and it was lower in the CsA-GTE group than in the CsA group. Cyclosporine 76-79 renin Rattus norvegicus 19-24 20947539-6 2011 The total level of renin protein expression was significantly higher in the CsA group than in the control group, and it was lower in the CsA-GTE group than in the CsA group. csa-gte 137-144 renin Rattus norvegicus 19-24 20947539-6 2011 The total level of renin protein expression was significantly higher in the CsA group than in the control group, and it was lower in the CsA-GTE group than in the CsA group. Cyclosporine 137-140 renin Rattus norvegicus 19-24 20947539-7 2011 CONCLUSIONS: CsA treatment increases the PRA and intrarenal renin levels and induces nephrotoxicity. Cyclosporine 13-16 renin Rattus norvegicus 60-65 21282553-7 2011 In primary cultures of inner medullary CD cells, renin mRNA and (pro)renin protein levels increased with Ang II (100 nmol/L), and candesartan (Ang II type 1 receptor antagonist) prevented this effect. Cadmium 39-41 renin Rattus norvegicus 49-54 21282553-10 2011 Furthermore, protein kinase C activation with phorbol 12-myristate 13-acetate increased renin expression to the same extent as Ang II. Tetradecanoylphorbol Acetate 46-77 renin Rattus norvegicus 88-93 21242461-6 2011 Blood urea nitrogen (BUN) and plasma creatinine levels were elevated in the Ren-/- strain (BUN 112 +- 7 versus 23 +- 2 mg/dL and creatinine 0.53 +- 0.02 versus 0.26 +- 0.02 mg/dL), and kidney morphology was abnormal with a rudimentary inner renal medulla, cortical interstitial fibrosis, thickening of arterial walls, and abnormally shaped glomeruli. Nitrogen 11-19 renin Rattus norvegicus 76-79 21242461-6 2011 Blood urea nitrogen (BUN) and plasma creatinine levels were elevated in the Ren-/- strain (BUN 112 +- 7 versus 23 +- 2 mg/dL and creatinine 0.53 +- 0.02 versus 0.26 +- 0.02 mg/dL), and kidney morphology was abnormal with a rudimentary inner renal medulla, cortical interstitial fibrosis, thickening of arterial walls, and abnormally shaped glomeruli. Creatinine 37-47 renin Rattus norvegicus 76-79 21242461-6 2011 Blood urea nitrogen (BUN) and plasma creatinine levels were elevated in the Ren-/- strain (BUN 112 +- 7 versus 23 +- 2 mg/dL and creatinine 0.53 +- 0.02 versus 0.26 +- 0.02 mg/dL), and kidney morphology was abnormal with a rudimentary inner renal medulla, cortical interstitial fibrosis, thickening of arterial walls, and abnormally shaped glomeruli. Creatinine 129-139 renin Rattus norvegicus 76-79 21168472-0 2011 Reactive oxygen and nitrogen species balance in the determination of thyroid hormones-induced cardiac hypertrophy mediated by renin-angiotensin system. reactive oxygen and 0-19 renin Rattus norvegicus 126-131 21168472-7 2011 In conclusion, ROS/NO balance may play a role in the control of thyroid hormone-induced cardiac hypertrophy mediated by renin-angiotensin system. Reactive Oxygen Species 15-18 renin Rattus norvegicus 120-125 21168472-0 2011 Reactive oxygen and nitrogen species balance in the determination of thyroid hormones-induced cardiac hypertrophy mediated by renin-angiotensin system. nitrogen species 20-36 renin Rattus norvegicus 126-131 21068087-2 2011 Rats induced with I3C developed malignant hypertension and exhibited alterations in the expression of renin and (P)RR expressed by the CD cells. Cadmium 135-137 renin Rattus norvegicus 102-107 21068087-6 2011 The data suggest that upregulation of renin and the s(P)RR in the CD, especially in the renal medullary tissues of Cyp1a1Ren2 transgenic rats with malignant hypertension, along with the previously demonstrated increased availability of AGT in the urine of these rats, may constitute a leading mechanism to explain elevated formation of kidney ANG II levels in this model of ANG II-dependent hypertension. Cadmium 66-68 renin Rattus norvegicus 38-43 21293118-0 2011 Effects of an N-type calcium antagonist on angiotensin II-renin feedback. Calcium 21-28 renin Rattus norvegicus 58-63 20884641-5 2011 Renin caused an unexpected effect on the length of cardiomyocytes that was inhibited by mannose-6-phosphate and monensin, but not by administration of glucose-6-phosphate. mannose-6-phosphate 88-107 renin Rattus norvegicus 0-5 21045727-6 2011 RESULTS: Adult DEX-treated offspring were hypertensive (SBP, 140.1 +- 2.4 vs. 128.6 +- 3.2 mmHg; P = 0.009), hypokalemic (4.5 +- 0.2 vs. 5.1 +- 0.2 mmol/l; P = 0.03) and had suppressed plasma renin concentration (23.6 +- 4.8 vs. 43.8 +- 5.9 ng/ml; P = 0.017). Dexamethasone 15-18 renin Rattus norvegicus 192-197 21293118-6 2011 Cilnidipine suppressed the increase in plasma renin activity and plasma Ang II levels induced by valsartan, but amlodipine did not. cilnidipine 0-11 renin Rattus norvegicus 46-51 21293118-6 2011 Cilnidipine suppressed the increase in plasma renin activity and plasma Ang II levels induced by valsartan, but amlodipine did not. Valsartan 97-106 renin Rattus norvegicus 46-51 20852041-0 2010 Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene. dahl salt 123-132 renin Rattus norvegicus 143-148 21785727-5 2011 Moreover, increased activity of the renin-angiotensin and sympathetic nervous systems leading to downregulation of receptors may be responsible for the blunted vascular sensitivity to angiotensin II and catecholamines, respectively. Catecholamines 203-217 renin Rattus norvegicus 36-41 21785727-7 2011 In this paper, we address the role played by the renin-angiotensin and sympathetic nervous systems in the haemodynamic alterations that occur due to prolonged consumption of fructose. Fructose 174-182 renin Rattus norvegicus 49-54 21057043-10 2011 Our data suggest that the beneficial effect of telmisartan and olmesartan on cardiac structure and function may be predominantly pressor-related or angiotensin type 1 receptor dependent in this model of renin-angiotensin system activation. Telmisartan 47-58 renin Rattus norvegicus 203-208 21057043-10 2011 Our data suggest that the beneficial effect of telmisartan and olmesartan on cardiac structure and function may be predominantly pressor-related or angiotensin type 1 receptor dependent in this model of renin-angiotensin system activation. olmesartan 63-73 renin Rattus norvegicus 203-208 20823693-0 2011 Blockade of the Renin-Angiotensin system improves insulin receptor signaling and insulin-stimulated skeletal muscle glucose transport in burn injury. Glucose 116-123 renin Rattus norvegicus 16-21 20823693-2 2011 We have reported that blockade of the renin-angiotensin system with losartan, an angiotensin II type 1 (AT1) receptor blocker, improves whole body insulin sensitivity and glucose metabolism after burn injury. Losartan 68-76 renin Rattus norvegicus 38-43 20852041-4 2010 In congenic rats receiving the BN renin allele, vasodilator responses to ACh were eliminated by nitric oxide synthase inhibition with N(G)-nitro-l-arginine methyl ester, angiotensin-converting enzyme inhibition with captopril, and AT(1) receptor blockade with losartan. Acetylcholine 73-76 renin Rattus norvegicus 34-39 20852041-4 2010 In congenic rats receiving the BN renin allele, vasodilator responses to ACh were eliminated by nitric oxide synthase inhibition with N(G)-nitro-l-arginine methyl ester, angiotensin-converting enzyme inhibition with captopril, and AT(1) receptor blockade with losartan. NG-Nitroarginine Methyl Ester 134-168 renin Rattus norvegicus 34-39 20852041-4 2010 In congenic rats receiving the BN renin allele, vasodilator responses to ACh were eliminated by nitric oxide synthase inhibition with N(G)-nitro-l-arginine methyl ester, angiotensin-converting enzyme inhibition with captopril, and AT(1) receptor blockade with losartan. Captopril 216-225 renin Rattus norvegicus 34-39 20852041-4 2010 In congenic rats receiving the BN renin allele, vasodilator responses to ACh were eliminated by nitric oxide synthase inhibition with N(G)-nitro-l-arginine methyl ester, angiotensin-converting enzyme inhibition with captopril, and AT(1) receptor blockade with losartan. Losartan 260-268 renin Rattus norvegicus 34-39 20852041-6 2010 These findings indicate that the presence of the Dahl SS renin allele plays a crucial role in endothelial dysfunction present in the cerebral circulation of the Dahl SS rat, even in the absence of elevated dietary salt intake, and that introgression of the BN renin allele rescues endothelium-dependent vasodilator responses by restoring normal activation of the renin-angiotensin system. Salts 214-218 renin Rattus norvegicus 57-62 20940627-7 2010 Administration of the PRR blocker, handle region peptide, led to a significant decrease in 6-hydroxydopamine-induced DA cell death in the cultures,whereas administration of renin with simultaneous blockade of angiotensin receptors led to an increase in 6-hydroxydopamine-induced cell death. Oxidopamine 253-270 renin Rattus norvegicus 173-178 20229032-0 2010 Prenatal exposure to inflammation induced by zymosan results in activation of intrarenal renin-angiotensin system in adult offspring rats. Zymosan 45-52 renin Rattus norvegicus 89-94 20229032-2 2010 The present study was to explore the role of intrarenal renin-angiotensin (Ang) system in the development of hypertension programmed by prenatal exposure to zymosan. Zymosan 157-164 renin Rattus norvegicus 56-61 20229032-6 2010 The renal cortex renin mRNA expression, Ang II-positive cells in renal cortex, and Ang II expression in renal medulla increased significantly in offspring of zymosan-treated rats at 7, 16, and 25 weeks of age. Zymosan 158-165 renin Rattus norvegicus 17-22 20229032-8 2010 In conclusion, prenatal exposure to zymosan resulted in the activation of intrarenal renin-Ang system in adult offspring rats. Zymosan 36-43 renin Rattus norvegicus 85-90 20843686-0 2010 Design and optimization of new piperidines as renin inhibitors. Piperidines 31-42 renin Rattus norvegicus 46-51 20843686-1 2010 The discovery of a new series of piperidine-based renin inhibitors is described herein. piperidine 33-43 renin Rattus norvegicus 50-55 20697985-14 2010 Both LVH and proteomic changes can be prevented by blockade of renin-angiotensin system with telmisartan. Telmisartan 93-104 renin Rattus norvegicus 63-68 20685818-8 2010 Combination therapy and monotherapy of valsartan and aliskiren had a comparable enhancing effect on the mRNA expression of renin, whereas all these treatments did not affect the expression of the (pro)renin receptor. Valsartan 39-48 renin Rattus norvegicus 123-128 20685818-8 2010 Combination therapy and monotherapy of valsartan and aliskiren had a comparable enhancing effect on the mRNA expression of renin, whereas all these treatments did not affect the expression of the (pro)renin receptor. aliskiren 53-62 renin Rattus norvegicus 123-128 20837888-3 2010 In this study, we examined possible interactions between 20-HETE and the renin-angiotensin system. 20-Hete 57-64 renin Rattus norvegicus 73-78 20837888-8 2010 This is the first study to demonstrate that 20-HETE, a key constrictor eicosanoid in the microcirculation, induces ACE and angiotensin II type 1 receptor expression and increases angiotensin II levels, suggesting that the mechanisms by which 20-HETE promotes hypertension include activation of the renin-angiotensin system that is likely initiated at the level of ACE induction. 20-Hete 44-51 renin Rattus norvegicus 298-303 20660105-1 2010 In vitro, the renin-secreting juxtaglomerular cells express the calcium-sensing receptor, and its activation with the calcimimetic cinacalcet inhibits renin release. Cinacalcet 131-141 renin Rattus norvegicus 14-19 20660105-1 2010 In vitro, the renin-secreting juxtaglomerular cells express the calcium-sensing receptor, and its activation with the calcimimetic cinacalcet inhibits renin release. Cinacalcet 131-141 renin Rattus norvegicus 151-156 20660105-8 2010 Likewise, cinacalcet decreased furosemide-stimulated renin from 30.6 +- 2.3 to 21.3 +- 2.3 ng ANG I ml(-1) h(-1) (P < 0.001). Cinacalcet 10-20 renin Rattus norvegicus 53-58 20660105-3 2010 Since cinacalcet inhibits parathyroid hormone, which may stimulate renin activity, we sought to determine whether cinacalcet inhibits renin activity by decreasing parathyroid hormone. Cinacalcet 114-124 renin Rattus norvegicus 134-139 20660105-8 2010 Likewise, cinacalcet decreased furosemide-stimulated renin from 30.6 +- 2.3 to 21.3 +- 2.3 ng ANG I ml(-1) h(-1) (P < 0.001). Furosemide 31-41 renin Rattus norvegicus 53-58 20660105-9 2010 In parathyroidectomized rats, cinacalcet decreased renin activity from 9.3 +- 1.3 to 5.2 +- 0.5 ng ANG I ml(-1) h(-1) (P < 0.05) similar to sham-operated controls (13.5 +- 2.2 to 6.6 +- 0.8 ng ANG I ml(-1) h(-1), P < 0.05). Cinacalcet 30-40 renin Rattus norvegicus 51-56 20660105-4 2010 Lastly, we hypothesized that chronically administered cinacalcet would inhibit basal and stimulated renin in conscious rats. Cinacalcet 54-64 renin Rattus norvegicus 100-105 20660105-7 2010 Acute administration of cinacalcet decreased basal renin activity from 13.6 +- 2.4 to 6.1 +- 1.1 ng ANG I ml(-1) h(-1) (P < 0.001). Cinacalcet 24-34 renin Rattus norvegicus 51-56 20733093-10 2010 In conclusion, sunitinib induces a reversible rise in BP in patients and in rats associated with activation of the endothelin-1 system, suppression of the renin-angiotensin system, and generalized microvascular dysfunction. Sunitinib 15-24 renin Rattus norvegicus 155-160 20625318-0 2010 Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats. aliskiren 50-59 renin Rattus norvegicus 34-39 20625318-1 2010 BACKGROUND: The blood pressure-lowering effect of the renin inhibitor aliskiren equals that of angiotensin-converting enzyme (ACE) inhibitors and angiotensin (Ang) II type 1 (AT1) receptor blockers. aliskiren 70-79 renin Rattus norvegicus 54-59 20625318-9 2010 Aliskiren reduced plasma renin activity and the plasma and tissue angiotensin levels at 1 week of treatment; yet, after 3 weeks of aliskiren treatment only the cardiac angiotensin levels remained suppressed, whereas no tissue angiotensin reductions were seen with captopril or irbesartan. aliskiren 0-9 renin Rattus norvegicus 25-30 20172005-5 2010 Low-salt feeding elevated the plasma renin activity and aldosterone concentration, resulting in significant increases in Ang I and Ang II levels in the plasma or kidney tissue, as compared with the normal- or high-salt group. Salts 4-8 renin Rattus norvegicus 37-42 20804606-0 2010 High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine. Sugars 5-10 renin Rattus norvegicus 26-31 20804606-0 2010 High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine. Taurine 130-137 renin Rattus norvegicus 26-31 20804606-1 2010 Perinatal taurine depletion leads to several physiological impairments in adult life, in part, due to taurine"s effects on the renin-angiotensin system, a crucial regulator of growth and differentiation during early life. Taurine 10-17 renin Rattus norvegicus 127-132 20804606-1 2010 Perinatal taurine depletion leads to several physiological impairments in adult life, in part, due to taurine"s effects on the renin-angiotensin system, a crucial regulator of growth and differentiation during early life. Taurine 102-109 renin Rattus norvegicus 127-132 20804606-2 2010 The present study tests the hypothesis that perinatal taurine depletion predisposes adult female rats to impaired baroreceptor control of arterial pressure by altering the renin-angiotensin system. Taurine 54-61 renin Rattus norvegicus 172-177 20804606-11 2010 The present data indicate that in perinatal taurine depleted female rats, the renin-angiotensin system underlines the ability of high sugar intake to blunt baroreceptor responses. Taurine 44-51 renin Rattus norvegicus 78-83 20804606-11 2010 The present data indicate that in perinatal taurine depleted female rats, the renin-angiotensin system underlines the ability of high sugar intake to blunt baroreceptor responses. Sugars 134-139 renin Rattus norvegicus 78-83 20226201-1 2010 A water deprived animal that ingests only water efficiently corrects its intracellular dehydration, but remains hypovolemic, in negative sodium balance, and with high plasma renin activity and angiotensin II. Water 2-7 renin Rattus norvegicus 174-179 20360313-0 2010 Hydrogen sulfide inhibits plasma renin activity. Hydrogen Sulfide 0-16 renin Rattus norvegicus 33-38 20360313-1 2010 The development of renovascular hypertension depends on the release of renin from the juxtaglomerular (JG) cells, a process regulated by intracellular cAMP. Cyclic AMP 151-155 renin Rattus norvegicus 71-76 20360313-2 2010 Hydrogen sulfide (H2S) downregulates cAMP production in some cell types by inhibiting adenylyl cyclase, suggesting the possibility that it may modulate renin release. Hydrogen Sulfide 0-16 renin Rattus norvegicus 152-157 20360313-2 2010 Hydrogen sulfide (H2S) downregulates cAMP production in some cell types by inhibiting adenylyl cyclase, suggesting the possibility that it may modulate renin release. Hydrogen Sulfide 18-21 renin Rattus norvegicus 152-157 20360313-3 2010 Here, we investigated the effect of H2S on plasma renin activity and BP in rat models of renovascular hypertension. Hydrogen Sulfide 36-39 renin Rattus norvegicus 50-55 20360313-5 2010 Compared with vehicle, NaHS significantly attenuated the elevation in plasma renin activity and angiotensin II levels but did not affect plasma angiotensin-converting enzyme activity. sodium bisulfide 23-27 renin Rattus norvegicus 77-82 20360313-6 2010 Furthermore, NaHS inhibited the upregulation of renin mRNA and protein levels in the clipped kidneys of 2K1C rats. sodium bisulfide 13-17 renin Rattus norvegicus 48-53 20360313-7 2010 In primary cultures of renin-rich kidney cells, NaHS markedly suppressed forskolin-stimulated renin activity in the medium and the intracellular increase in cAMP. sodium bisulfide 48-52 renin Rattus norvegicus 23-28 20360313-7 2010 In primary cultures of renin-rich kidney cells, NaHS markedly suppressed forskolin-stimulated renin activity in the medium and the intracellular increase in cAMP. sodium bisulfide 48-52 renin Rattus norvegicus 94-99 20360313-7 2010 In primary cultures of renin-rich kidney cells, NaHS markedly suppressed forskolin-stimulated renin activity in the medium and the intracellular increase in cAMP. Colforsin 73-82 renin Rattus norvegicus 23-28 20360313-7 2010 In primary cultures of renin-rich kidney cells, NaHS markedly suppressed forskolin-stimulated renin activity in the medium and the intracellular increase in cAMP. Colforsin 73-82 renin Rattus norvegicus 94-99 20360313-9 2010 In conclusion, these results demonstrate that H2S may inhibit renin activity by decreasing the synthesis and release of renin, suggesting its potential therapeutic value for renovascular hypertension. Hydrogen Sulfide 46-49 renin Rattus norvegicus 62-67 20360313-9 2010 In conclusion, these results demonstrate that H2S may inhibit renin activity by decreasing the synthesis and release of renin, suggesting its potential therapeutic value for renovascular hypertension. Hydrogen Sulfide 46-49 renin Rattus norvegicus 120-125 20616348-1 2010 Vitamin D inhibits renin expression and blocks the compensatory induction of renin associated with the use of renin-angiotensin system inhibitors. Vitamin D 0-9 renin Rattus norvegicus 19-24 20616348-1 2010 Vitamin D inhibits renin expression and blocks the compensatory induction of renin associated with the use of renin-angiotensin system inhibitors. Vitamin D 0-9 renin Rattus norvegicus 77-82 20616348-1 2010 Vitamin D inhibits renin expression and blocks the compensatory induction of renin associated with the use of renin-angiotensin system inhibitors. Vitamin D 0-9 renin Rattus norvegicus 77-82 20616348-8 2010 Renal and cardiac renin expression was markedly increased in losartan-treated animals, but nearly normalized with combination therapy. Losartan 61-69 renin Rattus norvegicus 18-23 20616348-10 2010 These data demonstrate that vitamin D analogs have potent antihypertrophic activity in part via suppression of renin in the kidney and heart, and combination of these analogs with losartan achieves much better therapeutic effects because of the blockade of the compensatory renin increase. Vitamin D 28-37 renin Rattus norvegicus 111-116 20616348-10 2010 These data demonstrate that vitamin D analogs have potent antihypertrophic activity in part via suppression of renin in the kidney and heart, and combination of these analogs with losartan achieves much better therapeutic effects because of the blockade of the compensatory renin increase. Vitamin D 28-37 renin Rattus norvegicus 274-279 20616348-10 2010 These data demonstrate that vitamin D analogs have potent antihypertrophic activity in part via suppression of renin in the kidney and heart, and combination of these analogs with losartan achieves much better therapeutic effects because of the blockade of the compensatory renin increase. Losartan 180-188 renin Rattus norvegicus 274-279 20613628-0 2010 Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models. Nitric Oxide 0-12 renin Rattus norvegicus 107-112 20613628-0 2010 Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models. Nitric Oxide 0-12 renin Rattus norvegicus 122-127 20225200-1 2010 Chronic heart rate reduction (HRR) therapy following myocardial infarction, using either the pure HRR agent ivabradine or the beta-blocker atenolol, has been shown to preserve maximal coronary perfusion, via reduction of perivascular collagen and a decrease in renin-angiotensin system activation. Atenolol 139-147 renin Rattus norvegicus 261-266 20364881-2 2010 The following studies investigated the interaction between chronic sodium appetite and the renin-angiotensin-aldosterone system on LHSS reward. lhss 131-135 renin Rattus norvegicus 91-96 20153844-9 2010 CIH-induced augmentation of chemoreflex sensitivity occurs, at least in part, via the renin-angiotensin system. cih 0-3 renin Rattus norvegicus 86-91 20206513-0 2010 Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension. amino propanamide 41-58 renin Rattus norvegicus 69-74 20206513-1 2010 The discovery and SAR of a new series of substituted amino propanamide renin inhibitors are herein described. amino propanamide 53-70 renin Rattus norvegicus 71-76 19959997-1 2010 BACKGROUND: This study determined whether transfer of the renin gene from the Dahl salt-resistant (Dahl R) strain into the Dahl salt-sensitive (SS) genetic background restores the relaxation of middle cerebral arteries (MCAs) to different vasodilator stimuli in S/renRR renin congenic (SS.SR-(D13N1 and Syt2)/Mcwi) (RGRR) rats maintained on low-salt (0.4% NaCl) diet. dahl salt 78-87 renin Rattus norvegicus 58-63 19959997-1 2010 BACKGROUND: This study determined whether transfer of the renin gene from the Dahl salt-resistant (Dahl R) strain into the Dahl salt-sensitive (SS) genetic background restores the relaxation of middle cerebral arteries (MCAs) to different vasodilator stimuli in S/renRR renin congenic (SS.SR-(D13N1 and Syt2)/Mcwi) (RGRR) rats maintained on low-salt (0.4% NaCl) diet. Salts 83-87 renin Rattus norvegicus 58-63 19959997-1 2010 BACKGROUND: This study determined whether transfer of the renin gene from the Dahl salt-resistant (Dahl R) strain into the Dahl salt-sensitive (SS) genetic background restores the relaxation of middle cerebral arteries (MCAs) to different vasodilator stimuli in S/renRR renin congenic (SS.SR-(D13N1 and Syt2)/Mcwi) (RGRR) rats maintained on low-salt (0.4% NaCl) diet. dahl salt 123-132 renin Rattus norvegicus 58-63 19959997-1 2010 BACKGROUND: This study determined whether transfer of the renin gene from the Dahl salt-resistant (Dahl R) strain into the Dahl salt-sensitive (SS) genetic background restores the relaxation of middle cerebral arteries (MCAs) to different vasodilator stimuli in S/renRR renin congenic (SS.SR-(D13N1 and Syt2)/Mcwi) (RGRR) rats maintained on low-salt (0.4% NaCl) diet. Sodium Chloride 356-360 renin Rattus norvegicus 58-63 19927008-2 2010 METHODS: Hypertension was induced in Cyp1a1-Ren-2 rats through dietary administration of the natural xenobiotic indole-3-carbinol (0.3%), which activates the renin gene. indole-3-carbinol 112-129 renin Rattus norvegicus 158-163 19959997-7 2010 CONCLUSIONS: (i) Restoration of normal regulation of the renin-angiotensin system restores dilations to ACh and hypoxia that are impaired in SS rats, (ii) prostacyclin signaling is impaired in SS and RGRR rats but intact in Dahl R rats, indicating that alleles other than the renin gene affect vascular relaxation in response to this agonist; and (iii) vascular smooth muscle sensitivity to NO is preserved in SS and RGRR and is not responsible for impaired arterial relaxation in response to ACh in SS rats. Acetylcholine 104-107 renin Rattus norvegicus 57-62 19959997-7 2010 CONCLUSIONS: (i) Restoration of normal regulation of the renin-angiotensin system restores dilations to ACh and hypoxia that are impaired in SS rats, (ii) prostacyclin signaling is impaired in SS and RGRR rats but intact in Dahl R rats, indicating that alleles other than the renin gene affect vascular relaxation in response to this agonist; and (iii) vascular smooth muscle sensitivity to NO is preserved in SS and RGRR and is not responsible for impaired arterial relaxation in response to ACh in SS rats. Acetylcholine 493-496 renin Rattus norvegicus 57-62 19927008-6 2010 RESULTS: Induction of the renin gene by administration of indole-3-carbinol resulted in normal-salt diet fed animals in the development of severe hypertension that was accompanied by marked increases in plasma and kidney ANG II levels. indole-3-carbinol 58-75 renin Rattus norvegicus 26-31 19927008-6 2010 RESULTS: Induction of the renin gene by administration of indole-3-carbinol resulted in normal-salt diet fed animals in the development of severe hypertension that was accompanied by marked increases in plasma and kidney ANG II levels. Salts 95-99 renin Rattus norvegicus 26-31 19927008-10 2010 CONCLUSION: Our results demonstrate that after induction of the renin gene in Cyp1a1-Ren-2 transgenic rats inappropriate increases in plasma and kidney ANG II levels in response to very high dietary salt intake are responsible for the development of severe hypertension in this model of inducible renin transgenic rats. Salts 199-203 renin Rattus norvegicus 64-69 19927008-10 2010 CONCLUSION: Our results demonstrate that after induction of the renin gene in Cyp1a1-Ren-2 transgenic rats inappropriate increases in plasma and kidney ANG II levels in response to very high dietary salt intake are responsible for the development of severe hypertension in this model of inducible renin transgenic rats. Salts 199-203 renin Rattus norvegicus 297-302 19945959-0 2010 Ioxitalamate induces renal tubular apoptosis via activation of renal efferent nerve-mediated adrenergic signaling, renin activity, and reactive oxygen species production in rats. ioxitalamic acid 0-12 renin Rattus norvegicus 115-120 19942928-0 2010 Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system. candesartan 9-20 renin Rattus norvegicus 78-83 19861503-0 2009 Glucose promotes the production of interleukine-1beta and cyclooxygenase-2 in mesangial cells via enhanced (Pro)renin receptor expression. Glucose 0-7 renin Rattus norvegicus 112-117 20228412-12 2010 The increased activation of the renin-angiotensin system after mercury treatment might be associated to this increased COX-2 activity. Mercury 63-70 renin Rattus norvegicus 32-37 21042014-6 2010 Nebivolol did not alter the salt-induced increase in blood pressure but reduced urinary protein excretion, plasma renin concentration, and nitroxidative stress. Nebivolol 0-9 renin Rattus norvegicus 114-119 20029960-0 2010 The inhibitory effects of rosiglitazone on cardiac hypertrophy through modulating the renin-angiotensin system in diet-induced hypercholesterolemic rats. Rosiglitazone 26-39 renin Rattus norvegicus 86-91 19946038-6 2010 RESULTS: Salt excess increased arterial pressure (p < 0.05) and plasma renin and angiotensin II concentrations (p < 0.05). Salts 9-13 renin Rattus norvegicus 71-95 19648480-6 2010 Second, brain mineralocorticoid receptors may influence sympathetic drive by upregulating the activity of the brain renin-angiotensin system, resulting in NAD(P)H oxidase-dependent superoxide production. Superoxides 181-191 renin Rattus norvegicus 116-121 20924146-1 2010 Nicotianamine (NA), which is obtained from vegetables, lowers blood pressure through the renin-angiotensin system, and we clarified that NA preferentially inhibits the activity of angiotensin I-converting enzyme (ACE)-a zinc-containing enzyme. nicotianamine 0-13 renin Rattus norvegicus 89-94 19861503-6 2009 The results showed that D-glucose treatment up-regulates prorenin, renin, angiotensin II, PRR, IL-1beta, and COX-2 mRNA and protein expression and increases phosphorylation of ERK1/2, c-Jun N-terminal kinase, c-Jun, and nuclear factor-kappaB (NF-kappaB) p65 (serine 276,468 and 536), respectively. Glucose 24-33 renin Rattus norvegicus 60-65 19861503-10 2009 We conclude that glucose induces the up-regulation of PRR and its ligands prorenin and renin, leading to increased IL-1beta and COX-2 production via the angiotensin II-dependent pathway. Glucose 17-24 renin Rattus norvegicus 77-82 20097963-0 2009 Cyclic AMP increases cytoplasmic free calcium in renin-secreting cells from rat kidney. Cyclic AMP 0-10 renin Rattus norvegicus 49-54 20097963-0 2009 Cyclic AMP increases cytoplasmic free calcium in renin-secreting cells from rat kidney. Calcium 38-45 renin Rattus norvegicus 49-54 20097963-2 2009 The control of renin secretion is complex with increases in cAMP being the major stimulus and increases in intracellular free Ca2+ concentration ([Ca2+]i) being inhibitory. Cyclic AMP 60-64 renin Rattus norvegicus 15-20 20097963-9 2009 One could speculate that this increase in [Ca2+]i serves to finely adjust the stimulating effect cAMP-increasing signals on the renin-angiotensin system. Cyclic AMP 97-101 renin Rattus norvegicus 128-133 19246535-0 2009 Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression. Glucose 81-88 renin Rattus norvegicus 7-12 19593209-4 2009 In vivo, we measured the impact of R-568 (20 ng/min intravenously) on the acute changes in plasma renin activity (PRA) induced by either a 90 min infusion of the angiotensin-converting enzyme inhibitor captopril, or the beta-receptor agonist isoproterenol, or of a vehicle in or after a furosemide challenge in conscious Wistar rats. N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine 35-40 renin Rattus norvegicus 98-103 19593209-4 2009 In vivo, we measured the impact of R-568 (20 ng/min intravenously) on the acute changes in plasma renin activity (PRA) induced by either a 90 min infusion of the angiotensin-converting enzyme inhibitor captopril, or the beta-receptor agonist isoproterenol, or of a vehicle in or after a furosemide challenge in conscious Wistar rats. Captopril 202-211 renin Rattus norvegicus 98-103 19593209-5 2009 RESULTS: In vitro, R-568 dose-dependently blunted renin release, but also reduced the increase in renin due to forskolin (P < 0.01). Colforsin 111-120 renin Rattus norvegicus 98-103 19457666-0 2009 Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. alkyl amines 65-77 renin Rattus norvegicus 27-32 19816502-0 2009 Epigenetics, essential hypertension and renin-angiotensin system upregulation in the offspring of water-deprived pregnant rats. Water 98-103 renin Rattus norvegicus 40-45 20353010-0 2009 [Inhibitory effect on activated renin-angiotensin system by astragaloside IV in rats with pressure-overload induced cardiac hypertrophy]. astragaloside A 60-76 renin Rattus norvegicus 32-37 19597528-7 2009 ADT treatment increased renin and AGT mRNAs as well as Ang II protein, but did not affect the ACE mRNA level. adrenotensin 0-3 renin Rattus norvegicus 24-29 19358611-1 2009 Starting from known piperidine renin inhibitors, a new series of 3,9-diazabicyclo[3.3.1]nonene derivatives was rationally designed and prepared. 3,9-diazabicyclo[3.3.1]nonene 65-94 renin Rattus norvegicus 31-36 19358611-2 2009 Optimization of the positions 3, 6, and 7 of the diazabicyclonene template led to potent renin inhibitors. diazabicyclonene 49-65 renin Rattus norvegicus 89-94 19246535-9 2009 Renin inhibition improved systemic insulin sensitivity, insulin metabolic signaling, and glucose transport along with normalization of Ang II, AT(1)R, and MR levels, oxidative stress markers, fibrosis, and mitochondrial structural abnormalities. Glucose 89-96 renin Rattus norvegicus 0-5 19246535-10 2009 Our data suggest that renin inhibition improves systemic insulin sensitivity, skeletal muscle insulin metabolic signaling, and glucose transport in Ren2 rats. Glucose 127-134 renin Rattus norvegicus 22-27 19273740-2 2009 These studies investigated the hemodynamic and cardiac effects of monoblockade and coblockade of renin-angiotensin and sympathetic nervous systems. coblockade 83-93 renin Rattus norvegicus 97-102 19617656-1 2009 Histamine, acting centrally as a neurotransmitter, evokes a reversal of haemorrhagic shock in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides. Histamine 0-9 renin Rattus norvegicus 148-153 19225052-7 2009 Whereas L-NAME further decreased Do(2ren), Vo(2)(ren), CmicroPo(2), and MmicroPo(2) and deteriorated renal function, L-NIL partially prevented the drop of Do(2ren) and microPo(2), increased O(2)ER, restored Vo(2)(ren) and metabolic efficiency, and prevented deterioration of renal function. NG-Nitroarginine Methyl Ester 8-14 renin Rattus norvegicus 37-40 19225052-7 2009 Whereas L-NAME further decreased Do(2ren), Vo(2)(ren), CmicroPo(2), and MmicroPo(2) and deteriorated renal function, L-NIL partially prevented the drop of Do(2ren) and microPo(2), increased O(2)ER, restored Vo(2)(ren) and metabolic efficiency, and prevented deterioration of renal function. NG-Nitroarginine Methyl Ester 8-14 renin Rattus norvegicus 49-52 19225052-8 2009 Our results demonstrate that renal I/R induces early iNOS-dependent microvascular hypoxia in disrupting the balance between microvascular oxygen supply and Vo(2)(ren), whereas endothelial NO synthase activity is compulsory for the maintenance of this balance. Oxygen 138-144 renin Rattus norvegicus 29-32 19516179-0 2009 Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats. dahl salt 87-96 renin Rattus norvegicus 59-64 19139972-3 2009 The objective of this study was to investigate the existence of an interaction between the endothelin and renin angiotensin systems that may play a role in the development of fructose-induced hypertension. Fructose 175-183 renin Rattus norvegicus 106-111 19162104-1 2009 To determine the effect of perinatal exposure to nicotine on water intake and salt appetite related to renin-angiotensin system in the offspring, maternal rats during perinatal period [gestation (G) or gestation plus lactation (G+L)] were subcutaneously administrated with nicotine. Nicotine 49-57 renin Rattus norvegicus 103-108 19516179-3 2009 The renal renin-angiotensin-aldosterone system is activated in salt-sensitive hypertensive rats with in-vitro studies showing aldosterone increases angiotensin-converting enzyme (ACE) activity, renin production and angiotensin II type 1 receptor (AT1R) activity. Salts 63-67 renin Rattus norvegicus 10-15 19516179-3 2009 The renal renin-angiotensin-aldosterone system is activated in salt-sensitive hypertensive rats with in-vitro studies showing aldosterone increases angiotensin-converting enzyme (ACE) activity, renin production and angiotensin II type 1 receptor (AT1R) activity. Salts 63-67 renin Rattus norvegicus 194-199 19516179-6 2009 RESULTS: Dahl salt-sensitive rats fed a high-salt diet had increased kidney/body weight (175%) and urinary protein excretion (886%) and decreased plasma renin activity and plasma aldosterone concentration. dahl salt 9-18 renin Rattus norvegicus 153-158 19516179-6 2009 RESULTS: Dahl salt-sensitive rats fed a high-salt diet had increased kidney/body weight (175%) and urinary protein excretion (886%) and decreased plasma renin activity and plasma aldosterone concentration. Salts 14-18 renin Rattus norvegicus 153-158 19516179-9 2009 CONCLUSION: A high salt diet increased the renal renin-angiotensin system, whereas blockade of mineralocorticoid receptors attenuated renal injuries by decreasing the activity of tissue renin-angiotensin system in Dahl salt-sensitive rats. Salts 19-23 renin Rattus norvegicus 49-54 19516179-9 2009 CONCLUSION: A high salt diet increased the renal renin-angiotensin system, whereas blockade of mineralocorticoid receptors attenuated renal injuries by decreasing the activity of tissue renin-angiotensin system in Dahl salt-sensitive rats. Salts 219-223 renin Rattus norvegicus 186-191 19516182-9 2009 In the pregnant Suramin-treated rats group, the renin levels increased (+122%) and the sFlt-1 levels decreased (-58%) during pregnancy. Suramin 16-23 renin Rattus norvegicus 48-53 18813285-0 2008 Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. paricalcitol 66-78 renin Rattus norvegicus 15-20 18984652-2 2009 Treatments of hypertensive rats with inhibitors of the renin-angiotensin system have been shown to restore both EDHF-mediated responses and the expression of connexins involved in the intercellular transfer of the hyperpolarization in mesenteric arteries. edhf 112-116 renin Rattus norvegicus 55-60 19239138-4 2009 The results showed that taurine increased serum levels of nitric oxide and nitric oxide synthase, inhibited the elevation of blood pressure, interfered with the activity of the renin-angiotensin-aldosterone system and minimized the elevation in serum cytokine, endothelin, neuropeptide Y and thromboxane B2. Taurine 24-31 renin Rattus norvegicus 177-182 18726873-11 2009 In contrast, plasma renin activity was significantly reduced in ZDF rats and normalized by ACE-inhibition. zdf 64-67 renin Rattus norvegicus 20-25 19126300-0 2009 Increased sensitivity to diltiazem hypotensive effect in an experimental model of high-renin hypertension. Diltiazem 25-34 renin Rattus norvegicus 87-92 19126300-1 2009 OBJECTIVES: The aim of this work was to evaluate the pharmacokinetic-pharmacodynamic properties of diltiazem in an experimental model of high-renin hypertension, such as the aortic coarctated (ACo) rat, to further characterize the responsiveness of this model to calcium channel blockers. Diltiazem 99-108 renin Rattus norvegicus 142-147 19126300-10 2009 In addition, our results suggested an increased sensitivity to diltiazem blood pressure lowering effect in experimental renovascular hypertension with high-renin levels. Diltiazem 63-72 renin Rattus norvegicus 156-161 19495699-6 2009 We have shown that alterations of the renin-angiotensin-aldosterone system, by manipulating sodium intake in the rats, reduced the pregnancy-induced remodeling of uterine arteries. Sodium 92-98 renin Rattus norvegicus 38-43 19330918-2 2009 METHODS: The renin gene was induced in Cyp1a1-Ren-2 rats through dietary administration of the natural xenobiotic indole-3-carbinol (I3C, 0.3%) for 12 and 24 h, respectively. indole-3-carbinol 114-131 renin Rattus norvegicus 13-18 19330918-2 2009 METHODS: The renin gene was induced in Cyp1a1-Ren-2 rats through dietary administration of the natural xenobiotic indole-3-carbinol (I3C, 0.3%) for 12 and 24 h, respectively. indole-3-carbinol 133-136 renin Rattus norvegicus 13-18 19038778-3 2009 Here, we describe the enzymatic introduction of a thioether ring in angiotensin [Ang-(1-7)], a heptapeptide that plays a pivotal role in the renin-angiotensin system and possesses important therapeutic activities. Sulfides 50-59 renin Rattus norvegicus 141-146 19286754-10 2009 Plasma renin activity (PRA) was inhibited in all salt groups and it was increased in T2 group. Salts 49-53 renin Rattus norvegicus 7-12 19145073-0 2009 Blockage of the renin-angiotensin system attenuates mortality but not vascular calcification in uremic rats: sevelamer carbonate prevents vascular calcification. Sevelamer 109-128 renin Rattus norvegicus 16-21 19155618-1 2009 BACKGROUND/AIMS: We hypothesized that renal damage induced by salt overload may be related to increased activity of the renin-angiotensin system. Salts 62-66 renin Rattus norvegicus 120-125 22435350-2 2009 Tetrahydropalmatine (THP), a derivative of the herb corydalis, may have analgesic properties (Hu & Jin, 2000a; Wei, Zou, Young, Dubner, & Ren, 1999); however, the mechanism of action is unclear. tetrahydropalmatine 0-19 renin Rattus norvegicus 146-149 22435350-2 2009 Tetrahydropalmatine (THP), a derivative of the herb corydalis, may have analgesic properties (Hu & Jin, 2000a; Wei, Zou, Young, Dubner, & Ren, 1999); however, the mechanism of action is unclear. tetrahydropalmatine 21-24 renin Rattus norvegicus 146-149 18813285-3 2008 Here we determined if the beneficial effects of paricalcitol (19-nor 1,25-dihydroxyvitamin D(2)) were associated with suppression of renin-angiotensin gene expression in the kidney. paricalcitol 48-60 renin Rattus norvegicus 133-138 18813285-3 2008 Here we determined if the beneficial effects of paricalcitol (19-nor 1,25-dihydroxyvitamin D(2)) were associated with suppression of renin-angiotensin gene expression in the kidney. 19-nor 1,25-dihydroxyvitamin d 62-92 renin Rattus norvegicus 133-138 18813285-5 2008 Paricalcitol was found to decrease angiotensinogen, renin, renin receptor, and vascular endothelial growth factor mRNA levels in the remnant kidney by 30-50 percent compared to untreated animals. paricalcitol 0-12 renin Rattus norvegicus 52-57 18083251-0 2008 Effects of ovariectomy and 17beta-estradiol treatment on the renin-angiotensin system, blood pressure, and endothelial ultrastructure. Estradiol 27-43 renin Rattus norvegicus 61-66 18083251-11 2008 These results strongly suggest that estradiol protects rats from the development of hypertension and has a protective effect on the endothelium by increasing NO and ANP levels while decreasing renin activity. Estradiol 36-45 renin Rattus norvegicus 193-198 18653711-4 2008 Renin is the rate-limiting step in the generation of angiotensin II (Ang II), which stimulates the generation of reactive oxygen species in a variety of tissues. Reactive Oxygen Species 113-136 renin Rattus norvegicus 0-5 18783396-1 2008 BACKGROUND: Alcoholic cardiomyopathy (ACM) develops in response to chronic alcohol intake and it is hypothesized that activation of the renin-angiotensin system (RAS) and disorders in energy metabolism may play important roles in its onset. Alcohols 75-82 renin Rattus norvegicus 136-141 18783396-10 2008 RESULTS: Compared with controls, myocardial angiotensin (Ang) I, Ang II, and renin levels were progressively increased at 2, 4, and 6 months of alcohol intake. Alcohols 144-151 renin Rattus norvegicus 77-82 18653711-10 2008 Collectively, these data suggest that pancreatic functional/structural changes are driven, in part, by tissue renin-angiotensin system-mediated increases in NADPH oxidase and reactive oxygen species generation, abnormalities attenuated with direct renin inhibition. Reactive Oxygen Species 175-198 renin Rattus norvegicus 110-115 18653711-10 2008 Collectively, these data suggest that pancreatic functional/structural changes are driven, in part, by tissue renin-angiotensin system-mediated increases in NADPH oxidase and reactive oxygen species generation, abnormalities attenuated with direct renin inhibition. Reactive Oxygen Species 175-198 renin Rattus norvegicus 248-253 18949179-1 2008 BACKGROUND: Central renin-angiotensin system modulates alcohol intake and inhibition of angiotensin converting enzyme reduces ethanol consumption in rats, and may be potentially useful in the treatment of alcoholism. Alcohols 55-62 renin Rattus norvegicus 20-25 19015602-12 2008 These results suggest that reducing the activity of renin-angiotensin system and insulin that lowers blood glucose level may improve autonomic nervous system dysfunction and neurohumoral regulation of the cardiovascular system in diabetic hypertensive rats. Glucose 107-114 renin Rattus norvegicus 52-57 18518880-0 2008 Central choline suppresses plasma renin response to graded haemorrhage in rats. Choline 8-15 renin Rattus norvegicus 34-39 18518880-2 2008 We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. Choline 21-28 renin Rattus norvegicus 53-58 18518880-21 2008 Pretreatment of rats with a vasopressin antagonist reversed central choline-induced inhibition of plasma renin responses to graded haemorrhage without altering the blood pressure response. Choline 68-75 renin Rattus norvegicus 105-110 18518880-22 2008 In conclusion, central administration of choline inhibits the plasma renin response to graded haemorrhage. Choline 41-48 renin Rattus norvegicus 69-74 18518883-9 2008 In the ARB-treated group, lower ICAM-1 expression was found in the cerebral cortex and slightly, albeit not significantly, lower expression of renin was found in the kidney. beta-L-Arabinose 7-10 renin Rattus norvegicus 143-148 18518883-12 2008 Such beneficial effects of ARB may be due, in part, to decreased blood pressure and is likely mainly due to inhibition of total circulating and local renin-angiotensin systems. beta-L-Arabinose 27-30 renin Rattus norvegicus 150-155 18782187-0 2008 A renin transcript lacking exon 1 encodes for a non-secretory intracellular renin that increases aldosterone production in transgenic rats. Aldosterone 97-108 renin Rattus norvegicus 2-7 18782187-0 2008 A renin transcript lacking exon 1 encodes for a non-secretory intracellular renin that increases aldosterone production in transgenic rats. Aldosterone 97-108 renin Rattus norvegicus 76-81 18782187-4 2008 We hypothesized that exon(2-9)renin (1) is translated into a functionally active protein in vivo, (2) is not secreted but remains within the cytoplasm and (3) stimulates aldosterone production. Aldosterone 170-181 renin Rattus norvegicus 30-35 18782187-10 2008 We conclude that the exon(1A-9) renin transcript (1) is translated into a functionally active intracellular protein; (2) is targeted to the cytoplasm rather than being sorted to the secretory pathways and (3) is functionally active, regulating aldosterone production. Aldosterone 244-255 renin Rattus norvegicus 32-37 18622246-12 2008 CONCLUSION: As oxonic acid diet increased plasma renin activity, plasma aldosterone, and urine K to Na ratio, these changes may play a significant role in the harmful cardiovascular actions of hyperuricemia. Oxonic Acid 15-26 renin Rattus norvegicus 49-54 18949179-1 2008 BACKGROUND: Central renin-angiotensin system modulates alcohol intake and inhibition of angiotensin converting enzyme reduces ethanol consumption in rats, and may be potentially useful in the treatment of alcoholism. Ethanol 126-133 renin Rattus norvegicus 20-25 18296558-0 2008 Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production. Glucose 88-95 renin Rattus norvegicus 32-37 18420994-11 2008 The inhibition of the renin-angiotensin system may contribute, at least in part, to the resveratrol-induced longevity and antiatherogenic effect of resveratrol. Resveratrol 88-99 renin Rattus norvegicus 22-27 18420994-11 2008 The inhibition of the renin-angiotensin system may contribute, at least in part, to the resveratrol-induced longevity and antiatherogenic effect of resveratrol. Resveratrol 148-159 renin Rattus norvegicus 22-27 18490518-1 2008 The aim of this study was to explore the effects of the renin inhibitor aliskiren in streptozotocin-diabetic TG(mRen-2)27 rats. aliskiren 72-81 renin Rattus norvegicus 56-61 18490518-2 2008 Furthermore, we investigated in vitro the effect of aliskiren on the interactions between renin and the (pro)renin receptor and between aliskiren and prorenin. aliskiren 52-61 renin Rattus norvegicus 90-123 18490518-9 2008 The evidence that aliskiren can reduce in vivo gene expression for the (pro)renin receptor and that it may block prorenin-induced angiotensin generation supports the need for additional work to reveal the mechanism of the observed renoprotection by this renin inhibitor. aliskiren 18-27 renin Rattus norvegicus 76-81 18413493-3 2008 Because diabetes mellitus, a disease with high intrarenal renin-Ang system and Ang II activity, is characterized by high prorenin levels, we hypothesized that the CD is the major source of prorenin in diabetes. Cadmium 163-165 renin Rattus norvegicus 58-63 18413493-6 2008 Ang II type 1 receptor blockade with Olmesartan reduced CD renin to control levels but significantly increased juxtaglomerular renin. olmesartan 37-47 renin Rattus norvegicus 59-64 18413493-6 2008 Ang II type 1 receptor blockade with Olmesartan reduced CD renin to control levels but significantly increased juxtaglomerular renin. olmesartan 37-47 renin Rattus norvegicus 127-132 18571395-8 2008 Centrally injected arachidonic acid increased plasma levels of all these hormones and renin activity. Arachidonic Acid 19-35 renin Rattus norvegicus 86-91 18571395-12 2008 In conclusion, our findings show that centrally administered arachidonic acid increases mean arterial pressure and decreases heart rate in normotensive conscious rats and the increases in plasma adrenaline, noradrenaline, vasopressin levels and renin activity appear to mediate the cardiovascular effects of the drug. Arachidonic Acid 61-77 renin Rattus norvegicus 245-250 18582458-0 2008 Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. Spironolactone 0-14 renin Rattus norvegicus 73-78 18582458-10 2008 These results suggest that spironolactone exerted renoprotective effects in uninephrectomized streptozotocin-induced diabetic rats and inhibited local renin-angiotensin-aldosterone system, such as the ACE expression and the hyperglycemia-induced overexpression of CYP11B2, in the kidney. Spironolactone 27-41 renin Rattus norvegicus 151-156 18460596-5 2008 Young (6- to 7-wk-old) heterozygous (+/-) male Ren2 and age-matched Sprague-Dawley rats were treated with the renin inhibitor aliskiren, which has high preferential affinity for human and mouse renin, an AT(1)R blocker, irbesartan, or placebo for 3 wk. aliskiren 126-135 renin Rattus norvegicus 110-115 18460596-5 2008 Young (6- to 7-wk-old) heterozygous (+/-) male Ren2 and age-matched Sprague-Dawley rats were treated with the renin inhibitor aliskiren, which has high preferential affinity for human and mouse renin, an AT(1)R blocker, irbesartan, or placebo for 3 wk. aliskiren 126-135 renin Rattus norvegicus 194-199 18388329-2 2008 Here we studied whether this rise in renin is attributable to an aliskiren-induced change in the prorenin conformation, allowing its detection in renin assays, or a change in renin/prorenin clearance. aliskiren 65-74 renin Rattus norvegicus 37-42 18388329-2 2008 Here we studied whether this rise in renin is attributable to an aliskiren-induced change in the prorenin conformation, allowing its detection in renin assays, or a change in renin/prorenin clearance. aliskiren 65-74 renin Rattus norvegicus 100-105 18388329-2 2008 Here we studied whether this rise in renin is attributable to an aliskiren-induced change in the prorenin conformation, allowing its detection in renin assays, or a change in renin/prorenin clearance. aliskiren 65-74 renin Rattus norvegicus 100-105 18388329-6 2008 Aliskiren did not affect binding at 4 degrees C. At 37 degrees C, aliskiren increased (pro)renin accumulation up to 40-fold, and M6PR blockade prevented this. aliskiren 66-75 renin Rattus norvegicus 91-96 18388329-9 2008 Both phenomena may contribute to the "renin" surge during aliskiren treatment, but because they depend on aliskiren binding, they will not result in angiotensin generation. aliskiren 58-67 renin Rattus norvegicus 38-43 18388329-9 2008 Both phenomena may contribute to the "renin" surge during aliskiren treatment, but because they depend on aliskiren binding, they will not result in angiotensin generation. aliskiren 106-115 renin Rattus norvegicus 38-43 18426992-8 2008 Upregulation of distal tubular renin helps to explain how sustained intrarenal angiotensin II formation occurs even during juxtaglomerular renin suppression, thus allowing maintained effects on tubular sodium reabsorption that contribute to the hypertension. Sodium 202-208 renin Rattus norvegicus 31-36 18326551-7 2008 Treatment of neurons with renin, in the presence of 2 microm losartan, caused a time- and dose-dependent stimulation of phosphorylation of extracellular signal related kinase ERK1 (p44) and ERK2 (p42) isoforms of mitogen-activated protein kinase. Losartan 61-69 renin Rattus norvegicus 26-31 18326551-9 2008 Electrophysiological recordings showed that treatment of the neurons with renin, in the presence of 2 microm losartan, resulted in a steady and stable decrease in action potential frequency. Losartan 109-117 renin Rattus norvegicus 74-79 18234741-1 2008 It was hypothesized that renal sympathetic nerve activity (RSNA) and neuronal nitric oxide synthase (nNOS) are involved in the acute inhibition of renin secretion and the natriuresis following slow NaCl loading (NaLoad) and that RSNA participates in the regulation of arterial blood pressure (MABP). rsna 59-63 renin Rattus norvegicus 147-152 18296558-9 2008 Consistent with intracellular synthesis, Western analysis showed increased intracellular levels of renin following stimulation with isoproterenol and high glucose. Isoproterenol 132-145 renin Rattus norvegicus 99-104 18296558-9 2008 Consistent with intracellular synthesis, Western analysis showed increased intracellular levels of renin following stimulation with isoproterenol and high glucose. Glucose 155-162 renin Rattus norvegicus 99-104 18296558-11 2008 High glucose resulted in increased transforming growth factor-beta and collagen-1 synthesis by cardiac fibroblasts that was partially inhibited by candesartan but completely prevented by renin and ACE inhibitors. Glucose 5-12 renin Rattus norvegicus 187-192 18179782-13 2008 Furosemide significantly elevated plasma renin activity and aldosterone concentration. Furosemide 0-10 renin Rattus norvegicus 41-46 18763636-8 2008 CONCLUSION: The compound Puerarin might have some functions on preventing ren by inhibiting expression of type IV collagen. puerarin 25-33 renin Rattus norvegicus 74-77 18289603-7 2008 The adult offspring of dams fed the low-salt diet, compared to those dams fed a normal-salt diet, presented the following: plasma leptin levels higher in males and lower in females; plasma renin activity higher in males but not in females; and no differences in body weight, mean arterial blood pressure or serum angiotensin-converting enzyme activity. Salts 40-44 renin Rattus norvegicus 189-194 18094033-8 2008 In conclusion, we have demonstrated that local activation of the renin-angiotensin system, via increased ROS generation, mediates COX-2 upregulation in hypertensive SS rats. Reactive Oxygen Species 105-108 renin Rattus norvegicus 65-70 18184739-1 2008 Renal oxygen consumption (Vo(2,ren)) is an important parameter that has been shown to be influenced by various pathophysiological circumstances. Oxygen 6-12 renin Rattus norvegicus 31-34 18184739-2 2008 Vo(2,ren) has to be repeatedly measured during an experiment to gain insight in the dynamics of (dys)regulation of oxygen metabolism. Oxygen 115-121 renin Rattus norvegicus 5-8 19343087-0 2008 Differential effect of low dose thiazides on the Renin Angiotensin system in genetically hypertensive and normotensive rats. Thiazides 32-41 renin Rattus norvegicus 49-54 18404603-1 2008 INTRODUCTION: We have previously demonstrated a profound hypotensive response to the angiotensin II type 1 (AT1)-receptor antagonist losartan in rats consuming a normal salt diet that is not seen in salt-loaded rats, presumably due to a suppression of the renin-angiotensin system (RAS) by high sodium levels. Losartan 133-141 renin Rattus norvegicus 256-261 18154949-2 2008 It has been reported that torasemide may block the renin-angiotensin-aldosterone system and therefore it might attenuate myocardial remodeling accompanied by left ventricular dysfunction. Torsemide 26-36 renin Rattus norvegicus 51-56 18156191-0 2008 All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system. 2-octenal 4-9 renin Rattus norvegicus 107-112 18156191-0 2008 All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system. Tretinoin 10-23 renin Rattus norvegicus 107-112 18156191-9 2008 The pressure overload-induced production of angiotensin II was inhibited by RA via upregulation of expression of angiotensin-converting enzyme (ACE)2 and through inhibition of the expression of cardiac and renal renin, angiotensinogen, ACE, and angiotensin type 1 receptor. Tretinoin 76-78 renin Rattus norvegicus 212-217 18156191-11 2008 These results demonstrate that RA has a significant inhibitory effect on pressure overload-induced cardiac remodeling, through inhibition of the expression of renin-angiotensin system components. Tretinoin 31-33 renin Rattus norvegicus 159-164 17828524-0 2007 Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats. aliskiren 0-9 renin Rattus norvegicus 19-24 18001696-1 2008 It has been reported that torasemide but not furosemide, may block the renin-angiotensin-aldosterone system and therefore it might attenuate myocardial remodeling accompanied by left ventricular (LV) dysfunction. Torsemide 26-36 renin Rattus norvegicus 71-76 18202178-3 2008 In isolated rat bronchial rings, mast cell degranulation released enzyme with angiotensin I-forming activity blocked by the selective renin inhibitor BILA2157. Bila 2157 BS 150-158 renin Rattus norvegicus 134-139 17951998-9 2008 The high-salt diet significantly lowered plasma renin activity (PRA) in SRR but not in the SSR. Salts 9-13 renin Rattus norvegicus 48-53 17906098-0 2007 Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats. Steroids 9-17 renin Rattus norvegicus 33-38 17670863-0 2007 NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats. Cyclic GMP 7-11 renin Rattus norvegicus 59-64 17670863-4 2007 LNa(+), VAL, PD, l-NAME, and ODQ increased RRC, ANG II, and renin mRNA. Valsartan 8-11 renin Rattus norvegicus 60-65 17670863-4 2007 LNa(+), VAL, PD, l-NAME, and ODQ increased RRC, ANG II, and renin mRNA. NG-Nitroarginine Methyl Ester 17-23 renin Rattus norvegicus 60-65 17670863-7 2007 Combined treatment with PD, l-NAME, or ODQ and VAL reversed the effects of VAL and caused further increase in RRC, ANG II, renin mRNA, and protein. NG-Nitroarginine Methyl Ester 28-34 renin Rattus norvegicus 123-128 17670863-7 2007 Combined treatment with PD, l-NAME, or ODQ and VAL reversed the effects of VAL and caused further increase in RRC, ANG II, renin mRNA, and protein. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 39-42 renin Rattus norvegicus 123-128 17670863-7 2007 Combined treatment with PD, l-NAME, or ODQ and VAL reversed the effects of VAL and caused further increase in RRC, ANG II, renin mRNA, and protein. Valsartan 47-50 renin Rattus norvegicus 123-128 17670863-7 2007 Combined treatment with PD, l-NAME, or ODQ and VAL reversed the effects of VAL and caused further increase in RRC, ANG II, renin mRNA, and protein. Valsartan 75-78 renin Rattus norvegicus 123-128 17670863-10 2007 Reversal of the PD effects by SNAP and SNAP effects by ODQ confirms that NO and cGMP mediate the AT(2) receptor inhibition of renal renin production. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 55-58 renin Rattus norvegicus 132-137 17670863-10 2007 Reversal of the PD effects by SNAP and SNAP effects by ODQ confirms that NO and cGMP mediate the AT(2) receptor inhibition of renal renin production. Cyclic GMP 80-84 renin Rattus norvegicus 132-137 17586415-9 2007 Renin-angiotensin system inhibition reduced cardiac expression of NAD(P)H oxidative components p22phox, p47phox, and gp91phox. nad(p)h 66-73 renin Rattus norvegicus 0-5 17664394-7 2007 Maternal dexamethasone also programmed increased expression of renal and adipose angiotensin-converting enzyme and renal renin, but among these changes, only that of renal angiotensin-converting enzyme was prevented by the omega-3 diet. Dexamethasone 9-22 renin Rattus norvegicus 121-126 17483239-7 2007 Western analysis showed increased intracellular levels of angiotensinogen, renin, and chymase in high-glucose-exposed cells. Glucose 102-109 renin Rattus norvegicus 75-80 17596529-0 2007 Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension. tetradecythioacetic acid 23-47 renin Rattus norvegicus 55-60 17596529-13 2007 The results indicate that TTA downregulates the renin-angiotensin system in high renin animals but has no effect in low renin models. tta 26-29 renin Rattus norvegicus 48-53 17596529-13 2007 The results indicate that TTA downregulates the renin-angiotensin system in high renin animals but has no effect in low renin models. tta 26-29 renin Rattus norvegicus 81-86 17596529-13 2007 The results indicate that TTA downregulates the renin-angiotensin system in high renin animals but has no effect in low renin models. tta 26-29 renin Rattus norvegicus 81-86 17522264-4 2007 Studies were conducted in (mRen-2)27 rat, a transgenic rodent with hypertension and an enhanced renin-angiotensin system that following induction of diabetes with streptozotocin develops many of the features of diabetic nephropathy. Streptozocin 163-177 renin Rattus norvegicus 96-101 17531930-10 2007 CONCLUSIONS: These findings suggest a specific renal renin-angiotensin-sympathetic activation as a potential mechanism for the cardiovascular changes in response to chronic sucrose feeding. Sucrose 173-180 renin Rattus norvegicus 53-58 17376760-2 2007 Therefore, we studied the effect of the COX-2 inhibitor SC-58236 on the regulation of the renin system in adult rat kidneys. 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 56-64 renin Rattus norvegicus 90-95 17376760-5 2007 Isoproterenol or left renal artery clipping for 2 days increased PRA and renin mRNA to similar levels in both vehicle- and SC-58236-treated rats after 2 days. Isoproterenol 0-13 renin Rattus norvegicus 73-78 17376760-5 2007 Isoproterenol or left renal artery clipping for 2 days increased PRA and renin mRNA to similar levels in both vehicle- and SC-58236-treated rats after 2 days. 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 123-131 renin Rattus norvegicus 73-78 17442727-7 2007 Losartan and PD-123319 each increased vascular renin distribution in both kidneys. Losartan 0-8 renin Rattus norvegicus 47-52 17442727-7 2007 Losartan and PD-123319 each increased vascular renin distribution in both kidneys. PD 123319 13-22 renin Rattus norvegicus 47-52 17531930-0 2007 Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats. Sucrose 84-91 renin Rattus norvegicus 16-21 17531930-9 2007 The depressor response to hexamethonium was similar in both groups, whereas captopril caused a more pronounced decrease in BP in the sucrose group than in controls (-40 +/- 2 v -11 +/- 2 mm Hg), possibly reflecting the higher plasma renin activity and plasma content of angiotensin II and renal angiotensin II in sucrose rats. Captopril 76-85 renin Rattus norvegicus 233-238 17376760-6 2007 Pretreatment with SC-58236 for 5 days, however, reduced the absolute increase in PRA and renin mRNA levels. 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 18-26 renin Rattus norvegicus 89-94 17531930-9 2007 The depressor response to hexamethonium was similar in both groups, whereas captopril caused a more pronounced decrease in BP in the sucrose group than in controls (-40 +/- 2 v -11 +/- 2 mm Hg), possibly reflecting the higher plasma renin activity and plasma content of angiotensin II and renal angiotensin II in sucrose rats. Sucrose 133-140 renin Rattus norvegicus 233-238 17438306-9 2007 Hypertensive groups displayed reduced plasma renin concentrations during high sodium conditions and hypertrophic kidneys and hearts with various degrees of histopathologic changes. Sodium 78-84 renin Rattus norvegicus 45-50 17376760-8 2007 Similar findings were observed for the stimulation of the renin system by angiotensin II inhibition and low salt intake. Salts 108-112 renin Rattus norvegicus 58-63 16924413-10 2007 To investigate the possible role of the activation of the renin-angiotensin system (RAS) on the change in cell communication, diabetic rats were treated with enalapril (25 mg/Kg/day) for a period of 14 days. Enalapril 158-167 renin Rattus norvegicus 58-63 17254779-3 2007 Amazingly, there is ample precedence for the antiproliferative action of vitamin-D-related compounds and their role as endocrine suppressors of renin biosynthesis. Vitamin D 73-82 renin Rattus norvegicus 144-149 17196676-7 2007 A decrease in renal renin and angiotensinogen-mRNAs and in plasma ANG II and plasma renin activity was also found in salt overloaded animals. Salts 117-121 renin Rattus norvegicus 20-25 17196676-7 2007 A decrease in renal renin and angiotensinogen-mRNAs and in plasma ANG II and plasma renin activity was also found in salt overloaded animals. Salts 117-121 renin Rattus norvegicus 84-89 17196676-9 2007 Plasma ANG I and II and plasma renin activity were higher in low- than in normal-salt rats. Salts 81-85 renin Rattus norvegicus 31-36 17360952-7 2007 Moreover, plasma renin concentration was significantly lower in PAC1-/- compared with their wild-type littermates under control conditions as well as under a low- or high-salt diet and under treatment with the angiotensin-converting enzyme inhibitor ramipril, whereas no differences in plasma renin concentration between the genotypes were detectable after water deprivation. Salts 171-175 renin Rattus norvegicus 17-22 17360952-7 2007 Moreover, plasma renin concentration was significantly lower in PAC1-/- compared with their wild-type littermates under control conditions as well as under a low- or high-salt diet and under treatment with the angiotensin-converting enzyme inhibitor ramipril, whereas no differences in plasma renin concentration between the genotypes were detectable after water deprivation. Ramipril 250-258 renin Rattus norvegicus 17-22 17360952-7 2007 Moreover, plasma renin concentration was significantly lower in PAC1-/- compared with their wild-type littermates under control conditions as well as under a low- or high-salt diet and under treatment with the angiotensin-converting enzyme inhibitor ramipril, whereas no differences in plasma renin concentration between the genotypes were detectable after water deprivation. Water 357-362 renin Rattus norvegicus 17-22 16149109-2 2006 The beneficial effects of ACE inhibitors appear to result primarily from the suppression of the plasma renin-angiotensin-aldesterone system. aldesterone 121-132 renin Rattus norvegicus 103-108 17460373-0 2007 Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury. NG-Nitroarginine Methyl Ester 100-106 renin Rattus norvegicus 30-35 17613133-13 2007 Moderate chronic or high acute exposure to Glycyrrhizic Acid, Ammonium Glycyrrhizate, and their metabolites have been demonstrated to cause transient systemic alterations, including increased potassium excretion, sodium and water retention, body weight gain, alkalosis, suppression of the renin-angiotensis-aldosterone system, hypertension, and muscular paralysis; possibly through inhibition of 11beta -hydroxysteroid dehydrogenase-2 (11beta -OHSD2) in the kidney. Glycyrrhizic Acid 43-60 renin Rattus norvegicus 289-294 17613133-13 2007 Moderate chronic or high acute exposure to Glycyrrhizic Acid, Ammonium Glycyrrhizate, and their metabolites have been demonstrated to cause transient systemic alterations, including increased potassium excretion, sodium and water retention, body weight gain, alkalosis, suppression of the renin-angiotensis-aldosterone system, hypertension, and muscular paralysis; possibly through inhibition of 11beta -hydroxysteroid dehydrogenase-2 (11beta -OHSD2) in the kidney. AMMONIUM GLYCYRRHIZINATE 62-84 renin Rattus norvegicus 289-294 16899518-0 2006 Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system. Doxorubicin 59-69 renin Rattus norvegicus 130-135 16942944-9 2006 CONCLUSIONS: We have demonstrated the renin-angiotensin-aldosterone system may play a key role in the establishment of end-organ salt sensitivity, and the period of lactation in critical for salt sensitivity in later life. Salts 129-133 renin Rattus norvegicus 38-43 16942944-9 2006 CONCLUSIONS: We have demonstrated the renin-angiotensin-aldosterone system may play a key role in the establishment of end-organ salt sensitivity, and the period of lactation in critical for salt sensitivity in later life. Salts 191-195 renin Rattus norvegicus 38-43 16847149-4 2006 The mRNA level of renin in the clipped kidney and the plasma renin activity were markedly reduced, and the plasma angiotensin II level tended to decrease after TTA treatment. 1-(carboxymethylthio)tetradecane 160-163 renin Rattus norvegicus 18-23 16820344-7 2006 This study concludes that the renin-angiotensin-aldosterone, natriuretic peptide, and bradykinin systems are directly involved in the pathogenesis of cardiovascular remodeling in the DOCA-salt model of hypertension in rats, which may be independent of their effects on blood pressure. Desoxycorticosterone Acetate 183-187 renin Rattus norvegicus 30-35 16473957-8 2006 Plasma renin activity was 61.9% higher in magnesium-deficient rats, but serum angiotensin-converting enzyme activity was comparable in the two groups. Magnesium 42-51 renin Rattus norvegicus 7-12 16455770-0 2006 Regulation of components of the brain and cardiac renin-angiotensin systems by 17beta-estradiol after myocardial infarction in female rats. Estradiol 79-95 renin Rattus norvegicus 50-55 16820344-7 2006 This study concludes that the renin-angiotensin-aldosterone, natriuretic peptide, and bradykinin systems are directly involved in the pathogenesis of cardiovascular remodeling in the DOCA-salt model of hypertension in rats, which may be independent of their effects on blood pressure. Salts 188-192 renin Rattus norvegicus 30-35 16449359-1 2006 The interaction between renin, nitric oxide (NO), and its second messenger cGMP is controversial. Cyclic GMP 75-79 renin Rattus norvegicus 24-29 16794495-10 2006 Plasma renin concentration was increased in the hydronephrotic group of animals compared to controls on all diets, but the difference was only significant on a normal salt diet, 165 +/- 15 versus 86 +/- 12 microGU/ml respectively. Salts 167-171 renin Rattus norvegicus 7-12 16449359-2 2006 cAMP is the stimulatory second messenger for renin but is degraded by phosphodiesterases (PDEs). Cyclic AMP 0-4 renin Rattus norvegicus 45-50 16449359-0 2006 cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3. Cyclic GMP 0-4 renin Rattus norvegicus 16-21 16449359-3 2006 We previously reported that increasing endogenous cGMP in rats by inhibiting its breakdown by PDE-5 stimulated renin secretion rate (RSR). Cyclic GMP 50-54 renin Rattus norvegicus 111-116 16449359-15 2006 The resulting increase in cAMP serves as an endogenous stimulus for renin secretion. Cyclic AMP 26-30 renin Rattus norvegicus 68-73 16638600-2 2006 Female sex steroids such as estrogen and progesterone are known modulators of the renin-angiotensin-aldosterone system. Steroids 11-19 renin Rattus norvegicus 82-87 16672142-5 2006 Uric acid causes hypertension in a rat model through the activation of the renin-angiotensin system, downregulation of nitric oxide, and induction of endothelial dysfunction and vascular smooth muscle proliferation. Uric Acid 0-9 renin Rattus norvegicus 75-80 16467505-2 2006 Both nitric oxide (NO) and prostaglandins have been considered to mediate or modulate the control of renin secretion. Nitric Oxide 5-17 renin Rattus norvegicus 101-106 16467505-2 2006 Both nitric oxide (NO) and prostaglandins have been considered to mediate or modulate the control of renin secretion. Prostaglandins 27-41 renin Rattus norvegicus 101-106 16413583-1 2006 Myocardial infarction (MI) activates the renin-angiotensin system in the heart and increases local production of aldosterone. Aldosterone 113-124 renin Rattus norvegicus 41-46 17209324-2 2006 Blood pressure measurements were done in anaesthetized animals while the activities of renin-angiotensin and parasympathetic nervous systems were determined by the effect of their inhibition on the arterial pressure and baroreflex sensitivity, via captopril infusion and vagotomy respectively. Captopril 248-257 renin Rattus norvegicus 87-92 17209324-13 2006 The results of the present study suggests that renin-angiotensin and autonomic nervous systems are impaired by dietary salt-loading, while prevention of salt-hypertension by calcium supplement is through modulation of these actions. Salts 119-123 renin Rattus norvegicus 47-52 16401765-9 2006 This suggests that renin receptor overexpression has resulted in increased intraadrenal angiotensin II, thereby provoking enhanced aldosterone generation in the absence of changes in plasma renin. Aldosterone 131-142 renin Rattus norvegicus 19-24 16714774-2 2006 It was found that two-week-treatment with AT(1) blocker losartan induced an increase in tissue renin activity in both parts of kidney causing subsequent elevation of plasma renin activity. Losartan 56-64 renin Rattus norvegicus 95-100 16714774-2 2006 It was found that two-week-treatment with AT(1) blocker losartan induced an increase in tissue renin activity in both parts of kidney causing subsequent elevation of plasma renin activity. Losartan 56-64 renin Rattus norvegicus 173-178 16714774-3 2006 Renin mRNA in losartan-treated rats was increased only in cortex, suggesting cortex origin of elevated renin activity in medulla. Losartan 14-22 renin Rattus norvegicus 0-5 16714774-3 2006 Renin mRNA in losartan-treated rats was increased only in cortex, suggesting cortex origin of elevated renin activity in medulla. Losartan 14-22 renin Rattus norvegicus 103-108 16549154-0 2006 Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in rats. Tacrolimus 87-97 renin Rattus norvegicus 18-23 16633090-8 2006 Treatment with darusentan also reduced cortical expression of alphaENaC and alpha(1)-Na(+), K(+)-ATPase and increased plasma aldosterone levels independently of blood pressure, electrolytes, renin activity, or angiotensin converting enzyme activity. darusentan 15-25 renin Rattus norvegicus 191-196 16522724-13 2006 Despite a striking increase in mesenteric artery contraction in Dex-treated rats, in vivo studies suggest that abnormalities of the renin-angiotensin-aldosterone system, rather than enhanced vascular contractility, may be responsible for the elevation of blood pressure in these animals. Dexamethasone 64-67 renin Rattus norvegicus 132-137 16549154-11 2006 In conclusion, the results of our study suggested that renin angiotensin inhibition down-regulates fibrogenic cytokine expression in rats displaying tacrolimus nephrotoxicity. Tacrolimus 149-159 renin Rattus norvegicus 55-60 16404618-2 2006 Ang II and the AT1 receptor play a critical role in the cell-signaling process responsible for the actions of renin-angiotensin system in the regulation of blood pressure, water-electrolyte homeostasis and cell growth. Water 172-177 renin Rattus norvegicus 110-115 16457788-1 2006 The continuous infusion for 7 days of the adenosine receptor antagonist 1,3-dipropyl-8-sulfophenylxanthine (DPSPX) causes a sustained hypertension in rats, with an enhancement of sympathetic neurotransmission and activation of the renin-angiotensin system. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 72-106 renin Rattus norvegicus 231-236 16457788-1 2006 The continuous infusion for 7 days of the adenosine receptor antagonist 1,3-dipropyl-8-sulfophenylxanthine (DPSPX) causes a sustained hypertension in rats, with an enhancement of sympathetic neurotransmission and activation of the renin-angiotensin system. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 108-113 renin Rattus norvegicus 231-236 16194576-7 2005 The effect of ANP(1-28) on renin and Ao mRNA expression were reproduced by 8-bromo-cyclic GMP. 8-bromocyclic GMP 75-93 renin Rattus norvegicus 27-32 16784545-2 2006 This study, performed in a normotensive rat model of endotoxemia, tests the hypotheses that endotoxemia impairs renal microvascular PO2 (microPO2) and oxygen consumption (VO2,ren), that endotoxemia is associated with a diminished kidney function, that fluid resuscitation can restore microPO2, VO2,ren and kidney function, and that colloids are more effective than crystalloids. PO-2 132-135 renin Rattus norvegicus 112-115 16784545-7 2006 HES200/0.5 and Ringer"s lactate increased the VO2,ren, in contrast to HES130/0.4. hes200 0-6 renin Rattus norvegicus 50-53 16784545-7 2006 HES200/0.5 and Ringer"s lactate increased the VO2,ren, in contrast to HES130/0.4. Lactic Acid 24-31 renin Rattus norvegicus 50-53 16229907-17 2005 Na and Cr excretions were decreased, while proteinuria and plasma ET-1 levels were normalized by losartan treatment, suggesting that renin-angiotensin system activation may have a role in leptin induced renal changes. Losartan 97-105 renin Rattus norvegicus 133-138 16292651-0 2006 Altered renin-angiotensin system gene expression causes renal hypoplasia in the rats with nitrofen-induced diaphragmatic hernia. nitrofen 90-98 renin Rattus norvegicus 8-13 16172423-1 2005 The dopaminergic and renin-angiotensin systems regulate blood pressure, in part, by affecting sodium transport in renal proximal tubules (RPTs). Sodium 94-100 renin Rattus norvegicus 21-26 16020656-9 2005 In the IAS SMC, H-77 (10 microM; renin inhibitor) and captopril (1 microM; ACE inhibitor) decreased the basal as well as Angen-increased levels of ANG II. H 77 16-20 renin Rattus norvegicus 33-38 16306796-6 2005 When renin-angiotensin system blockade was initiated in adult Lyon hypertensive rats with established hypertension, 10 mg/kg/d of losartan or 0.4 mg/kg/d of perindopril induced a significant regression in both blood pressure (15%-20%) and proteinuria (40%-50%) as did in young Lyon hypertensive rats; the combination treatment produced an additional effect only on blood pressure. Losartan 130-138 renin Rattus norvegicus 5-10 16306796-6 2005 When renin-angiotensin system blockade was initiated in adult Lyon hypertensive rats with established hypertension, 10 mg/kg/d of losartan or 0.4 mg/kg/d of perindopril induced a significant regression in both blood pressure (15%-20%) and proteinuria (40%-50%) as did in young Lyon hypertensive rats; the combination treatment produced an additional effect only on blood pressure. Perindopril 157-168 renin Rattus norvegicus 5-10 16256107-3 2005 Water intake, urine volume and urinary sodium were, or tended to be, slightly higher, while plasma renin activity was significantly lower in the GABA group than the GABA-free control group. gamma-Aminobutyric Acid 145-149 renin Rattus norvegicus 99-104 16256107-3 2005 Water intake, urine volume and urinary sodium were, or tended to be, slightly higher, while plasma renin activity was significantly lower in the GABA group than the GABA-free control group. gamma-Aminobutyric Acid 165-169 renin Rattus norvegicus 99-104 16085334-6 2005 RESULTS: In cirrhotic rats 10 mg/kg candoxatrilat significantly increased steady-state indocyanine green clearance (a parameter reflecting liver plasma flow) (P<0.01), decreased portal pressure (P<0.01), had no effect on arterial pressure and plasma renin activity but increased ANP plasma levels (P<0.05) and urinary excretions (P<0.01) of ANP and cGMP. candoxatrilat 36-49 renin Rattus norvegicus 256-261 16087785-7 2005 Captopril treatment in spontaneously hypertensive rats lowered mean arterial pressure, angiotensin II, oxidative stress, and endothelin, and increased plasma renin activity. Captopril 0-9 renin Rattus norvegicus 158-163 16087785-8 2005 In contrast, captopril increased plasma renin activity (suggesting effective captopril treatment) but did not significantly alter mean arterial pressure, angiotensin II, oxidative stress, or endothelin of Wistar Kyoto rats. Captopril 13-22 renin Rattus norvegicus 40-45 16225983-4 2005 We studied the effect of 13-cis-retinoic acid on the gene expression of mentioned elements of the renin-angiotensin system in tumour tissue. Isotretinoin 25-45 renin Rattus norvegicus 98-103 16107577-7 2005 After an infusion of AGE-RSA, renal expression of angiotensinogen, ACE, renin, and angiotensin receptor type 1 were increased significantly (all P < 0.01), and ACE activity was elevated. rabbit sperm membrane autoantigen 25-28 renin Rattus norvegicus 72-110 16129426-3 2005 Plasma renin activity decreased significantly with chronic salt loading and failed to increase by isoproterenol treatment, whereas it increased 2.33 fold (P<0.05) in animals kept on regular chow. Salts 59-63 renin Rattus norvegicus 7-12 16160604-3 2005 In carotid rings, the Ang I-induced vasoconstrictor effect was only partially inhibited by captopril or chymostatin, whereas that of tetradecapeptide renin substrate (TDP) was greatly inhibited by chymostatin but unaffected by captopril; however, Ang I- and TDP-induced effects were abolished by the combination of both inhibitors. chymostatin 197-208 renin Rattus norvegicus 150-155 16160604-3 2005 In carotid rings, the Ang I-induced vasoconstrictor effect was only partially inhibited by captopril or chymostatin, whereas that of tetradecapeptide renin substrate (TDP) was greatly inhibited by chymostatin but unaffected by captopril; however, Ang I- and TDP-induced effects were abolished by the combination of both inhibitors. Captopril 227-236 renin Rattus norvegicus 150-155 15894566-9 2005 Notably, rAdv.heNOS decreased plasma levels of norepinephrine and plasma renin activity in cold-exposed rats, which suggests that eNOS gene transfer may decrease the activities of the sympathetic nervous system and the renin-angiotensin system. Norepinephrine 47-61 renin Rattus norvegicus 219-224 15870381-7 2005 Similarly, renin immunoreactivity increased in medullary collecting ducts of ANG II-infused compared with sham-operated rats (2.5 +/- 0.3 vs. 1.0 +/- 0.2 DU; P < 0.001), which was also prevented by ARB (1.01 +/- 0.06). du 154-156 renin Rattus norvegicus 11-16 16419651-3 2005 The aim of this study was to determine the relationship between cAMP and TNF-a in skeletal muscle in connection with the renin-angiotensin system. Cyclic AMP 64-68 renin Rattus norvegicus 121-126 16103264-1 2005 We tested the hypothesis that the renin inhibitor aliskiren ameliorates organ damage in rats transgenic for human renin and angiotensinogen genes (double transgenic rat [dTGR]). aliskiren 50-59 renin Rattus norvegicus 34-39 15734891-9 2005 Furthermore, attenuation of alterations in beta-adrenergic system by imidapril or losartan may be due to blockade of the renin-angiotensin system in the AVS model of heart failure. imidapril 69-78 renin Rattus norvegicus 121-126 16139690-4 2005 Long-term treatment of rats with ouabain results in arterial hypertension, and 50% of Caucasians with low-renin hypertension have increased plasma concentrations of this cardenolide. Cardenolides 170-181 renin Rattus norvegicus 106-111 16011733-7 2005 In treated group: cardiac dimensions were reduced with left ventricular fractional shortening significantly increased in combination group (from 22.4 to 28%); captopril + furosemide animals had highest heart rate and lowest systolic and diastolic blood pressures; body and heart weight were reduced, but kidney weight was significantly increased with furosemide (1.7 g in control vs. 2 g in capto + furo); plasma renin activity and angiotensin 1 were greatly increased, and moderately stimulated in control. Captopril 159-168 renin Rattus norvegicus 413-418 16011733-7 2005 In treated group: cardiac dimensions were reduced with left ventricular fractional shortening significantly increased in combination group (from 22.4 to 28%); captopril + furosemide animals had highest heart rate and lowest systolic and diastolic blood pressures; body and heart weight were reduced, but kidney weight was significantly increased with furosemide (1.7 g in control vs. 2 g in capto + furo); plasma renin activity and angiotensin 1 were greatly increased, and moderately stimulated in control. Furosemide 171-181 renin Rattus norvegicus 413-418 16011733-7 2005 In treated group: cardiac dimensions were reduced with left ventricular fractional shortening significantly increased in combination group (from 22.4 to 28%); captopril + furosemide animals had highest heart rate and lowest systolic and diastolic blood pressures; body and heart weight were reduced, but kidney weight was significantly increased with furosemide (1.7 g in control vs. 2 g in capto + furo); plasma renin activity and angiotensin 1 were greatly increased, and moderately stimulated in control. capto 159-164 renin Rattus norvegicus 413-418 16011733-7 2005 In treated group: cardiac dimensions were reduced with left ventricular fractional shortening significantly increased in combination group (from 22.4 to 28%); captopril + furosemide animals had highest heart rate and lowest systolic and diastolic blood pressures; body and heart weight were reduced, but kidney weight was significantly increased with furosemide (1.7 g in control vs. 2 g in capto + furo); plasma renin activity and angiotensin 1 were greatly increased, and moderately stimulated in control. furo 171-175 renin Rattus norvegicus 413-418 15734891-9 2005 Furthermore, attenuation of alterations in beta-adrenergic system by imidapril or losartan may be due to blockade of the renin-angiotensin system in the AVS model of heart failure. Losartan 82-90 renin Rattus norvegicus 121-126 15778273-8 2005 These data suggest that SS rats may be less sensitive to vasodilator prostaglandins and that normalization of renin-angiotensin system regulation causes a switch from production of COX-derived vasoconstrictor metabolites (in SS rats) toward NO-dependent relaxation in response to ACh- and prostaglandin-dependent dilation in response to hypoxia in SS.13(BN) rats. Acetylcholine 280-283 renin Rattus norvegicus 110-115 15774768-1 2005 Previous studies in our laboratory demonstrated that rats exhibiting obesity in response to a moderately high-fat (MHF) diet developed hypertension associated with activation of the local and systemic renin-angiotensin system. monomethyl fumarate 115-118 renin Rattus norvegicus 201-206 16201455-1 2005 The purpose of the present study was to quantify the antihypertensive effect of the total flavonoid (TF), extracted from the seed of Astragalus complanatus R. Brown, and to observe its effect on the renin-angiotensin system (RAS) in both renal hypertensive rats (RHR) and spontaneously hypertensive rats (SHR). Flavonoids 90-99 renin Rattus norvegicus 199-204 15774768-10 2005 Moreover, these results demonstrate the ability of losartan to reverse the blood pressure increase from diet-induced obesity, supporting a primary role for the renin-angiotensin system in obesity-associated hypertension. Losartan 51-59 renin Rattus norvegicus 160-165 16151695-4 2005 The type 1b angiotensin II receptor gene (Agtrlb) maps within the confidence intervals of QTLs on RNO2 linked to plasma renin activity (Sr6, highly significant; LOD = 5.0) and to plasma aldosterone level (Sr7, suggestive; LOD = 2.0). rno2 98-102 renin Rattus norvegicus 120-125 16201455-1 2005 The purpose of the present study was to quantify the antihypertensive effect of the total flavonoid (TF), extracted from the seed of Astragalus complanatus R. Brown, and to observe its effect on the renin-angiotensin system (RAS) in both renal hypertensive rats (RHR) and spontaneously hypertensive rats (SHR). tf 101-103 renin Rattus norvegicus 199-204 15662229-11 2005 This suggests a role for NEP inhibition added to blockade of the renin-angiotensin system that may explain the greater efficacy of omapatrilat. omapatrilat 131-142 renin Rattus norvegicus 65-70 15774514-8 2005 Renal stereology showed no differences in kidney weight, glomerular number or volume in OHF compared with OC, but renin and Na+,K+-ATPase activity were significantly reduced in OHF compared with controls. ohf 177-180 renin Rattus norvegicus 114-119 15894893-1 2005 OBJECTIVE: We determined whether chronic reductions in carotid blood flow elicit salt-sensitive hypertension through regulation of the brain renin-angiotensin system (RAS). Salts 81-85 renin Rattus norvegicus 141-146 15792957-8 2005 Finally, we show that the intracellular domain of Notch1, Ets-1, and HOXD10.PBX1b.PREP1 activate the rat renin promoter cooperatively in COS-7 cells. carbonyl sulfide 137-140 renin Rattus norvegicus 105-110 15780097-10 2005 CONCLUSION: These findings suggest that under conditions of normal intrarenal RAS activity and increased intrarenal Ang II action by infusion of Ang II or by insertion of a renin gene in salt-replete conditions, Ang-(1-7) is not an important factor in the regulation of renal function. Salts 187-191 renin Rattus norvegicus 173-178 15743391-2 2005 METHODS: Mice and rats, with indwelling femoral arterial and venous catheters, were chronically administered angiotensin II or pharmacological inhibitors of the renin-angiotensin system as sodium intake was altered. Sodium 189-195 renin Rattus norvegicus 161-166 15743391-3 2005 RESULTS: Increasing sodium intake led to suppression of circulating renin, angiotensin II, and aldosterone in rats and mice in the absence of alterations in arterial blood pressure. Sodium 20-26 renin Rattus norvegicus 68-73 15732056-3 2005 When rendered sodium hungry by ivc renin or by sodium depletion, these sucklings prefer urine and NH4Cl to NaCl, dilute urine, or an NaCl and KCl mineral mix equimolar to urine; however, by 18 days of age, urine and NH4Cl are no longer preferred to NaCl. Sodium 14-20 renin Rattus norvegicus 35-40 15816358-0 2005 PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage. Dinoprostone 0-4 renin Rattus norvegicus 58-63 15816358-5 2005 PGE2-treatment ameliorated the decrease in urinary sodium excretion, and normalized serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and plasma renin observed in cirrhotic rats with ALD. Dinoprostone 0-4 renin Rattus norvegicus 180-185 15816410-7 2005 Treatment with enalapril, losartan and their combination attenuated the observed memory deficits indicating a possible role of renin angiotensin system in cognitive function. Enalapril 15-24 renin Rattus norvegicus 127-132 15816410-7 2005 Treatment with enalapril, losartan and their combination attenuated the observed memory deficits indicating a possible role of renin angiotensin system in cognitive function. Losartan 26-34 renin Rattus norvegicus 127-132 15662231-10 2005 CONCLUSIONS: Aliskiren is an orally effective, long-lasting renin inhibitor that shows antihypertensive efficacy in animals superior to previous renin inhibitors and at least equivalent to angiotensin-converting enzyme inhibitors and AT1-receptor blockers. aliskiren 13-22 renin Rattus norvegicus 60-65 15662231-10 2005 CONCLUSIONS: Aliskiren is an orally effective, long-lasting renin inhibitor that shows antihypertensive efficacy in animals superior to previous renin inhibitors and at least equivalent to angiotensin-converting enzyme inhibitors and AT1-receptor blockers. aliskiren 13-22 renin Rattus norvegicus 145-150 15534073-6 2005 Similarly, renal renin content and PRC increased in response to LS and increased further in response to combined LS and valsartan or PD administration. leucylserine 64-66 renin Rattus norvegicus 17-22 15539403-1 2005 We previously reported that sodium restriction during pregnancy reduces plasma volume expansion and promotes intra-uterine growth restriction (IUGR) in rats while it activates the renin-angiotensin-aldosterone system (RAAS). Sodium 28-34 renin Rattus norvegicus 180-185 15665860-18 2005 Furthermore, blockade of renin angiotensin system prevented the impairment of the ATP-mediated inotropic and [Ca(2+)](i) responses in the failing heart. Adenosine Triphosphate 82-85 renin Rattus norvegicus 25-30 15534073-6 2005 Similarly, renal renin content and PRC increased in response to LS and increased further in response to combined LS and valsartan or PD administration. Valsartan 120-129 renin Rattus norvegicus 17-22 15588734-0 2004 Role of the sympathetic and renin angiotensin systems in the glucose-induced increase of blood pressure in rats. Glucose 61-68 renin Rattus norvegicus 28-33 15304371-9 2004 In study 1, high NaCl markedly reduced plasma renin and aldosterone and its regulated proteins in whole kidney, i.e., the thiazide-sensitive Na-Cl cotransporter and the alpha- and gamma (70-kDa band)-subunits of the epithelial sodium channel. Sodium Chloride 17-21 renin Rattus norvegicus 46-51 15886499-8 2005 Urinary norepinephrine excretion, renal expression of renin mRNA and renal tissue levels of angiotensin II were increased only in the amlodipine-treated group. Amlodipine 134-144 renin Rattus norvegicus 54-59 15292048-3 2004 Physiological changes in the activity of the endogenous renin-angiotensin system were produced by alterations in dietary sodium intake. Sodium 121-127 renin Rattus norvegicus 56-61 15292048-5 2004 In low-sodium-diet rats with increased renin-angiotensin system activity, losartan steepened the renal vascular frequency response (i.e., greater attenuation); this was not seen in normal- or high-sodium-diet rats with normal or decreased renin-angiotensin system activity. Losartan 74-82 renin Rattus norvegicus 39-44 15292048-5 2004 In low-sodium-diet rats with increased renin-angiotensin system activity, losartan steepened the renal vascular frequency response (i.e., greater attenuation); this was not seen in normal- or high-sodium-diet rats with normal or decreased renin-angiotensin system activity. Losartan 74-82 renin Rattus norvegicus 239-244 15588734-7 2004 The present results suggest that the pressor effect induced by glucose has an early phase due to an increase of efferent sympathetic discharges and a delayed phase produced by the activation of the renin angiotensin system. Glucose 63-70 renin Rattus norvegicus 198-203 15894839-3 2004 Naf caused a significant decrease in Ald secretion rate compared to saline (1.99+/-0.32 vs. 3.42+/-0.56 ng/min, p <0.001), while adrenal blood flow, mean arterial pressure and plasma renin activity in the adrenal venous blood did not differ between the two groups. nafamostat 0-3 renin Rattus norvegicus 186-191 15590980-8 2004 In conclusion, our studies demonstrate that blockade of both ROS generation and activation of the intrarenal renin-angiotensin system improves the inhibitory action of insulin on ANG gene expression in IRPTCs in conditions of high glucose. Glucose 231-238 renin Rattus norvegicus 109-114 15238353-6 2004 Conversely, DEX-programmed females were hypertensive (by 11%, P < 0.05), with elevated hepatic angiotensinogen mRNA expression (by 9%, P < 0.05), plasma angiotensinogen (by 61%, P < 0.05), and renin activity (by 88%, P < 0.05). Dexamethasone 12-15 renin Rattus norvegicus 202-207 15726834-0 2004 Arteriolar responses to vasodilator stimuli and elevated P(O2) in renin congenic and Dahl salt-sensitive rats. Oxygen 59-61 renin Rattus norvegicus 66-71 15726834-2 2004 The goal of this study was to determine whether normal vascular reactivity could be restored by transferring the chromosomal region carrying the Dahl salt-resistant (R) renin gene into the Dahl salt-sensitive (SS) genetic background in a strain of renin congenic rats (RGRR). dahl salt 145-154 renin Rattus norvegicus 169-174 15726834-7 2004 CONCLUSIONS: These data suggest that transfer of the chromosomal region containing the renin gene is crucial in the recovery of ACh-induced dilation of arterioles in RGRR rats vs. SS rats, and that factors in the SS genetic background contribute to an enhanced sensitivity to elevated PO2, independent of genes on chromosome 13. Acetylcholine 128-131 renin Rattus norvegicus 87-92 15726834-7 2004 CONCLUSIONS: These data suggest that transfer of the chromosomal region containing the renin gene is crucial in the recovery of ACh-induced dilation of arterioles in RGRR rats vs. SS rats, and that factors in the SS genetic background contribute to an enhanced sensitivity to elevated PO2, independent of genes on chromosome 13. PO-2 285-288 renin Rattus norvegicus 87-92 15477225-0 2004 Contribution of the endothelin and renin-angiotensin systems to the vascular changes in rats chronically treated with ouabain. Ouabain 118-125 renin Rattus norvegicus 35-40 15496307-0 2004 Control of vascular changes by renin-angiotensin-aldosterone system in salt-sensitive hypertension. Salts 71-75 renin Rattus norvegicus 31-36 15644940-5 2004 The Ang II precursor renin substrate tetradecapeptide (RS-14P) was converted into Ang II by the rat MAB elastase-2 with the following kinetic constants: Km = 124 +/- 21 micromol x L(-1); Kcat = 629 min(-1); catalytic efficiency (Kcat /Km) = 5.1 min(-1) micro(mol/L)-1. rs-14p 55-61 renin Rattus norvegicus 21-26 15496307-1 2004 The purpose of this study was to investigate the role of the renin-angiotensin-aldosterone system in hypertension development and cardiovascular structural changes in a salt-sensitive hypertensive model induced by capsaicin (CAP). Salts 169-173 renin Rattus norvegicus 61-66 15496307-1 2004 The purpose of this study was to investigate the role of the renin-angiotensin-aldosterone system in hypertension development and cardiovascular structural changes in a salt-sensitive hypertensive model induced by capsaicin (CAP). Capsaicin 214-223 renin Rattus norvegicus 61-66 15496307-1 2004 The purpose of this study was to investigate the role of the renin-angiotensin-aldosterone system in hypertension development and cardiovascular structural changes in a salt-sensitive hypertensive model induced by capsaicin (CAP). Capsaicin 225-228 renin Rattus norvegicus 61-66 15496307-14 2004 The renin-angiotensin-aldosterone system is involved in this salt-sensitive model because treatment that interfered with this system also prevented the development of hypertension and vascular remodeling. Salts 61-65 renin Rattus norvegicus 4-9 15601320-2 2004 Two antihypertensive drugs with opposite effects on the renin-angiotensin system, an ACE inhibitor (angiotensin converting enzyme inhibitor) and a thiazide diuretic, modified the nephropathy. Thiazides 147-155 renin Rattus norvegicus 56-61 15016632-1 2004 Blockade of the renin-angiotensin system improves the impaired endothelium-dependent relaxations associated with hypertension and aging, partly through amelioration of endothelium-derived hyperpolarizing factor (EDHF)-mediated responses. endothelium-derived hyperpolarizing factor 168-210 renin Rattus norvegicus 16-21 15717137-13 2004 Both doses of perindopril inhibited activation of the renin-angiotensin system, whereas candesartan had weaker effects. Perindopril 14-25 renin Rattus norvegicus 54-59 15311109-10 2004 Plasma renin activity was decreased in DOCA-salt rats from 17 +/- 3 to 0.17 +/- 0.01 ng/ml per h and increased in 1K1C rats on low salt diet to 30 +/- 5 ng/ml per h. CONCLUSIONS: Since ETB is the predominant endothelin receptor in the kidneys, upregulation of the ETB receptor mediating vasodilation and downregulation of the ETA receptor mediating vasoconstriction would be compatible with a mainly renal counter-regulatory effect of endothelin-1 to hypertension. Desoxycorticosterone Acetate 39-43 renin Rattus norvegicus 7-12 15311109-10 2004 Plasma renin activity was decreased in DOCA-salt rats from 17 +/- 3 to 0.17 +/- 0.01 ng/ml per h and increased in 1K1C rats on low salt diet to 30 +/- 5 ng/ml per h. CONCLUSIONS: Since ETB is the predominant endothelin receptor in the kidneys, upregulation of the ETB receptor mediating vasodilation and downregulation of the ETA receptor mediating vasoconstriction would be compatible with a mainly renal counter-regulatory effect of endothelin-1 to hypertension. Salts 44-48 renin Rattus norvegicus 7-12 15311109-10 2004 Plasma renin activity was decreased in DOCA-salt rats from 17 +/- 3 to 0.17 +/- 0.01 ng/ml per h and increased in 1K1C rats on low salt diet to 30 +/- 5 ng/ml per h. CONCLUSIONS: Since ETB is the predominant endothelin receptor in the kidneys, upregulation of the ETB receptor mediating vasodilation and downregulation of the ETA receptor mediating vasoconstriction would be compatible with a mainly renal counter-regulatory effect of endothelin-1 to hypertension. Salts 131-135 renin Rattus norvegicus 7-12 15526251-0 2004 Renin-angiotensin system blockade prevents the increase in plasma transforming growth factor beta 1, and reduces proteinuria and kidney hypertrophy in the streptozotocin-diabetic rat. Streptozocin 155-169 renin Rattus norvegicus 0-5 15498265-12 2004 CONCLUSION: CIHO can cause the levels of circulating RA and ATII to increase, but has no effects on AT1R mRNA expression in tissue, which suggests that activated renin-angiotensin system may contribute to the pathogenesis of CIHO-induced hypertension. ciho 12-16 renin Rattus norvegicus 162-167 15498265-12 2004 CONCLUSION: CIHO can cause the levels of circulating RA and ATII to increase, but has no effects on AT1R mRNA expression in tissue, which suggests that activated renin-angiotensin system may contribute to the pathogenesis of CIHO-induced hypertension. ciho 225-229 renin Rattus norvegicus 162-167 15283769-2 2004 The macula densa is involved in regulating afferent arteriolar tone and renin release by sensing alterations in luminal chloride via changes in the rate of Na(+)/K(+)/2Cl(-) cotransport, and administration of non-specific cyclooxygenase inhibitors will blunt increases in renin release mediated by macula densa sensing of decreases in luminal NaCl. Chlorides 120-128 renin Rattus norvegicus 72-77 15283769-2 2004 The macula densa is involved in regulating afferent arteriolar tone and renin release by sensing alterations in luminal chloride via changes in the rate of Na(+)/K(+)/2Cl(-) cotransport, and administration of non-specific cyclooxygenase inhibitors will blunt increases in renin release mediated by macula densa sensing of decreases in luminal NaCl. Chlorides 120-128 renin Rattus norvegicus 272-277 15283769-7 2004 Previous studies demonstrated that alterations in intraluminal chloride concentration are the signal for macula densa regulation of tubuloglomerular feedback and renin secretion, with high chloride stimulating tubuloglomerular feedback and low chloride stimulating renin release. Chlorides 63-71 renin Rattus norvegicus 162-167 15283769-10 2004 In isolated perfused glomerular preparations, renin release induced by macula densa perfusion with a low chloride solution was inhibited by a COX-2 inhibitor but not a COX-1 inhibitor. Chlorides 105-113 renin Rattus norvegicus 46-51 15249110-4 2004 Plasma renin activity increased similarly in both groups after 5 ml/kg blood loss, but showed a significantly greater increase after 10 ml/kg blood loss in animals with 6-hydroxydopamine lesions than in those with sham lesions (increase of 13.8 +/- 2.0 ng/ml/h versus 8.4 +/- 1.2 ng/ml/h; P < 0.025). Oxidopamine 169-186 renin Rattus norvegicus 7-12 15180925-8 2004 Renin mRNA expression was regulated strictly in parallel in both kidneys, a low-salt diet or furosemide treatment stimulating and a high-salt diet suppressing it. Salts 80-84 renin Rattus norvegicus 0-5 15180925-8 2004 Renin mRNA expression was regulated strictly in parallel in both kidneys, a low-salt diet or furosemide treatment stimulating and a high-salt diet suppressing it. Furosemide 93-103 renin Rattus norvegicus 0-5 15180925-8 2004 Renin mRNA expression was regulated strictly in parallel in both kidneys, a low-salt diet or furosemide treatment stimulating and a high-salt diet suppressing it. Salts 137-141 renin Rattus norvegicus 0-5 15283769-11 2004 In vivo studies in rats indicated that increased renin release in response to low-salt diet, ACE inhibitor, loop diuretics or aortic coarctation could be inhibited by administration of COX-2-selective inhibitors. Salts 82-86 renin Rattus norvegicus 49-54 15016632-1 2004 Blockade of the renin-angiotensin system improves the impaired endothelium-dependent relaxations associated with hypertension and aging, partly through amelioration of endothelium-derived hyperpolarizing factor (EDHF)-mediated responses. edhf 212-216 renin Rattus norvegicus 16-21 15213268-0 2004 Intrarenal Renin-Angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis. Nitric Oxide 135-147 renin Rattus norvegicus 11-16 15149320-7 2004 Basal as well as furosemide-induced stimulation of plasma renin activity (PRA) and of renal renin mRNA was further enhanced by CsA. Furosemide 17-27 renin Rattus norvegicus 58-63 14722017-0 2004 High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. Glucose 5-12 renin Rattus norvegicus 52-57 15224206-6 2004 Decreased renin-angiotensin system activity might reduce aldosterone secretion, which in turn could result in (successively) urinary sodium loss, extracellular fluid volume contraction and reductions in glomerular filtration and renal plasma flow. Sodium 133-139 renin Rattus norvegicus 10-15 15149320-8 2004 In contrast, rofecoxib attenuated the furosemide-induced rise of PRA and of renin mRNA, both in the absence and in the presence of CsA. rofecoxib 13-22 renin Rattus norvegicus 76-81 15149320-8 2004 In contrast, rofecoxib attenuated the furosemide-induced rise of PRA and of renin mRNA, both in the absence and in the presence of CsA. Furosemide 38-48 renin Rattus norvegicus 76-81 15149320-11 2004 Since the furosemide-induced stimulation of the renin system is not attenuated by CsA but by COX-2 inhibition, we speculate that extrarenal COX-2-derived prostanoids may be involved in the stimulation of the renin system by CsA and by loop diuretics. Furosemide 10-20 renin Rattus norvegicus 48-53 15149320-11 2004 Since the furosemide-induced stimulation of the renin system is not attenuated by CsA but by COX-2 inhibition, we speculate that extrarenal COX-2-derived prostanoids may be involved in the stimulation of the renin system by CsA and by loop diuretics. Furosemide 10-20 renin Rattus norvegicus 208-213 15149320-11 2004 Since the furosemide-induced stimulation of the renin system is not attenuated by CsA but by COX-2 inhibition, we speculate that extrarenal COX-2-derived prostanoids may be involved in the stimulation of the renin system by CsA and by loop diuretics. Prostaglandins 154-165 renin Rattus norvegicus 48-53 15149320-11 2004 Since the furosemide-induced stimulation of the renin system is not attenuated by CsA but by COX-2 inhibition, we speculate that extrarenal COX-2-derived prostanoids may be involved in the stimulation of the renin system by CsA and by loop diuretics. Prostaglandins 154-165 renin Rattus norvegicus 208-213 15149320-7 2004 Basal as well as furosemide-induced stimulation of plasma renin activity (PRA) and of renal renin mRNA was further enhanced by CsA. Furosemide 17-27 renin Rattus norvegicus 92-97 15149320-7 2004 Basal as well as furosemide-induced stimulation of plasma renin activity (PRA) and of renal renin mRNA was further enhanced by CsA. Cyclosporine 127-130 renin Rattus norvegicus 92-97 15076169-6 2004 In rats fed the high-sodium diet, those treated with the enalapril 30 mg/kg plus losartan 30 mg/kg combination, despite complete functional RAS blockade, exhibited smaller decreases in blood pressure and renal resistance, lesser release of renin and angiotensinogen consumption, and a normal renal function. Enalapril 57-66 renin Rattus norvegicus 240-245 15110897-0 2004 Nitric oxide synthase inhibition accelerates the pressor response to low-dose angiotensin II, exacerbates target organ damage, and induces renin escape. Nitric Oxide 0-12 renin Rattus norvegicus 139-144 15110897-6 2004 In approximately half the rats infused with L-NAME + Ang II, plasma renin escaped from Ang II-induced suppression after day 4 of Ang II, and continued to increase for the duration of the study. NG-Nitroarginine Methyl Ester 44-50 renin Rattus norvegicus 68-73 15053813-9 2004 We conclude that chronic treatment with captopril or HS diet could reduce the exercise capacity in inactive normotensive rats, probably through chronic inhibition of the renin-angiotensin system. Captopril 40-49 renin Rattus norvegicus 170-175 14978165-14 2004 These results show for the first time that oxalate can activate the renal renin-angiotensin system and that oxalate-induced upregulation of OPN is in part mediated via renal renin-angiotensin system. Oxalates 43-50 renin Rattus norvegicus 74-79 14978165-14 2004 These results show for the first time that oxalate can activate the renal renin-angiotensin system and that oxalate-induced upregulation of OPN is in part mediated via renal renin-angiotensin system. Oxalates 108-115 renin Rattus norvegicus 174-179 15047614-0 2004 Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat. zdf 81-84 renin Rattus norvegicus 48-53 15134804-6 2004 Plasma aldosterone concentrations and plasma renin concentration were decreased by high salt intake in SHRSP. Salts 88-92 renin Rattus norvegicus 45-50 14521506-10 2004 We conclude that (i) the DOCA-induced aggravation of hypertension, ventricular hypertrophy and renal injury in SHRs is accompanied by augmented oxidative stress and increased levels of ET in the renal cortex, which could contribute to their development; and (ii) losartan reduced oxidative stress and renal Ang II and ET in SHRs and DOCA-treated SHRs, which might contribute to its antihypertensive and renoprotective effects, regardless of renin status. Desoxycorticosterone Acetate 25-29 renin Rattus norvegicus 441-446 15076169-6 2004 In rats fed the high-sodium diet, those treated with the enalapril 30 mg/kg plus losartan 30 mg/kg combination, despite complete functional RAS blockade, exhibited smaller decreases in blood pressure and renal resistance, lesser release of renin and angiotensinogen consumption, and a normal renal function. Losartan 81-89 renin Rattus norvegicus 240-245 15136973-2 2004 administration of renin (R) decreases urinary volume and increases urinary sodium excretion. Sodium 75-81 renin Rattus norvegicus 18-23 15082866-0 2004 Involvement of the renin-angiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats. Histamine 66-75 renin Rattus norvegicus 19-24 15082866-1 2004 The study was undertaken to examine the involvement of the renin-angiotensin system in the reversal by endogenous central histamine of critical haemorrhagic hypotension in anaesthetised Wistar rats. Histamine 122-131 renin Rattus norvegicus 59-64 15082866-11 2004 In conclusion, the renin-angiotensin system is involved in central histamine-induced resuscitating action in rats. Histamine 67-76 renin Rattus norvegicus 19-24 14749684-3 2004 In the study reported here we used a time-dependent rat model of cardiac injury wherein plasma levels of renin and Ang II are chronically suppressed by means of continuous treatment with aldosterone (0.75 microg/h) and 1% dietary NaCl. Aldosterone 187-198 renin Rattus norvegicus 105-110 14749684-3 2004 In the study reported here we used a time-dependent rat model of cardiac injury wherein plasma levels of renin and Ang II are chronically suppressed by means of continuous treatment with aldosterone (0.75 microg/h) and 1% dietary NaCl. Sodium Chloride 230-234 renin Rattus norvegicus 105-110 15499208-7 2004 Calcium oxalate crystal deposition in the rat kidneys also activates the renin-angiotensin system. Calcium Oxalate 0-15 renin Rattus norvegicus 73-78 15218317-11 2004 Adrenal renin was up-regulated in 5/6 nephrectomy and further stimulated with spironolactone, possibly serving as a stimulus for the adrenal aldosterone synthesis. Spironolactone 78-92 renin Rattus norvegicus 8-13 15218317-11 2004 Adrenal renin was up-regulated in 5/6 nephrectomy and further stimulated with spironolactone, possibly serving as a stimulus for the adrenal aldosterone synthesis. Aldosterone 141-152 renin Rattus norvegicus 8-13 12925450-1 2003 BACKGROUND: We recently reported that arterial superoxide (O2-) is augmented by increased endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt hypertension, a model of low renin hypertension. Superoxides 47-57 renin Rattus norvegicus 182-187 14664716-1 2003 Previous studies have shown that the expression of the major components from a local pancreatic renin-angiotensin system (RAS) was upregulated after chronic exposure to oxygen deprivation (10% oxygen). Oxygen 169-175 renin Rattus norvegicus 96-101 14664716-1 2003 Previous studies have shown that the expression of the major components from a local pancreatic renin-angiotensin system (RAS) was upregulated after chronic exposure to oxygen deprivation (10% oxygen). Oxygen 193-199 renin Rattus norvegicus 96-101 12842816-9 2003 Because the brain renin-angiotensin system only contributes to salt-induced hypertension in Dahl S rats, further studies are needed to determine which of the salt-induced increases in brain AT1 receptor densities contribute to the hypertension and which to other aspects of body homeostasis. Salts 63-67 renin Rattus norvegicus 18-23 12842816-9 2003 Because the brain renin-angiotensin system only contributes to salt-induced hypertension in Dahl S rats, further studies are needed to determine which of the salt-induced increases in brain AT1 receptor densities contribute to the hypertension and which to other aspects of body homeostasis. Salts 158-162 renin Rattus norvegicus 18-23 12960040-6 2003 Glucosamine stimulated ANG and renin mRNA expression and enhanced p38 MAPK, ATF-2, and CREB phosphorylation in normal glucose (5 mm) medium. Glucosamine 0-11 renin Rattus norvegicus 31-36 14659064-1 2003 OBJECTIVE: To investigate the role of renin angiotensin system (RAS) activation in cyclosporine A nephropathy. Cyclosporine 83-97 renin Rattus norvegicus 38-43 12851254-6 2003 Because NH4Cl intake increases plasma renin and aldosterone, we asked if upregulation of the renin-angiotensin system reduces net H+ secretion. Ammonium Chloride 8-13 renin Rattus norvegicus 38-43 14517226-2 2003 We have recently reported that both endothelin-1 (ET-1) and vascular cellular adhesion molecule-1 (VCAM-1) levels, key early markers of atherosclerosis, are significantly elevated in carotid arteries of deoxycorticosterone acetate (DOCA)-salt hypertensive rats, a model known for its suppressed plasma renin levels. Desoxycorticosterone Acetate 203-230 renin Rattus norvegicus 302-307 12907131-2 2003 The aim of this study was to evaluate the effects of renin-anigiotensin system blockage, either by angiotensin-converting enzyme inhibition or angiotensin receptor blockage, on oxidative stress and nitric oxide release in diabetic rat kidneys. Nitric Oxide 198-210 renin Rattus norvegicus 53-58 12925450-9 2003 CONCLUSIONS: These results indicate that a BH4 deficiency resulting from ET-1-induced O2- via an ETA/NADPH oxidase pathway leads to endothelial dysfunction, and gene transfer of GTPCH I reverses the BH4 deficiency and endothelial dysfunction by reducing O2- in low renin mineralocorticoid hypertension. sapropterin 43-46 renin Rattus norvegicus 265-270 12925450-1 2003 BACKGROUND: We recently reported that arterial superoxide (O2-) is augmented by increased endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt hypertension, a model of low renin hypertension. Superoxides 59-61 renin Rattus norvegicus 182-187 12750060-9 2003 By contrast, captopril lowered the lower limit even in the absence of circulating renin and hence appeared to exert its effect on components of the renin-angiotensin system in the cerebral resistance vessel walls. Captopril 13-22 renin Rattus norvegicus 82-87 12750060-9 2003 By contrast, captopril lowered the lower limit even in the absence of circulating renin and hence appeared to exert its effect on components of the renin-angiotensin system in the cerebral resistance vessel walls. Captopril 13-22 renin Rattus norvegicus 148-153 12741953-5 2003 Omapatrilat inhibited plasma ACE and increased plasma renin activity (P <0.01). omapatrilat 0-11 renin Rattus norvegicus 54-59 12911623-6 2003 Functional analysis of transfected HEK293, LTK- and COS-7 cells, based on both cAMP and Ca2+ signalling assays, revealed that Ren1 was not activated by any of the known biogenic amines tested and several related metabolites. carbonyl sulfide 52-55 renin Rattus norvegicus 126-130 12911623-6 2003 Functional analysis of transfected HEK293, LTK- and COS-7 cells, based on both cAMP and Ca2+ signalling assays, revealed that Ren1 was not activated by any of the known biogenic amines tested and several related metabolites. Cyclic AMP 79-83 renin Rattus norvegicus 126-130 12911623-7 2003 The results indicated, however, that cells stably expressing Ren1 contained, on average, an 11-fold higher level of cAMP than the controls, in the absence of agonist stimulation. Cyclic AMP 116-120 renin Rattus norvegicus 61-65 12911623-8 2003 The high basal cAMP levels were shown to be specific for Ren1 and to vary proportionally with the level of Ren1 expressed in the transfected cells. Cyclic AMP 15-19 renin Rattus norvegicus 57-61 12911623-8 2003 The high basal cAMP levels were shown to be specific for Ren1 and to vary proportionally with the level of Ren1 expressed in the transfected cells. Cyclic AMP 15-19 renin Rattus norvegicus 107-111 12869388-0 2003 ATP-dependent mechanism for coordination of intercellular Ca2+ signaling and renin secretion in rat juxtaglomerular cells. Adenosine Triphosphate 0-3 renin Rattus norvegicus 77-82 12954402-7 2003 Plasma renin activity was elevated substantially in HCZ-treated rats, but aldosterone concentration was decreased. Hydrochlorothiazide 52-55 renin Rattus norvegicus 7-12 12869388-7 2003 Administration of ATP into isolated perfused rat kidneys induced a rapid, potent, and persistent inhibition of renin secretion, together with a transient elevation of renal vascular resistance. Adenosine Triphosphate 18-21 renin Rattus norvegicus 111-116 12869388-8 2003 ATP (1 mmol/L) caused up to 79% reduction of the renin secretion activated by lowering the renal perfusion flow (P<0.01). Adenosine Triphosphate 0-3 renin Rattus norvegicus 49-54 12869388-9 2003 Taken together, our results indicate that under mechanical stimulation, ATP functions as a paracellular mediator to regulate renin secretion, possibly through modulating intra- and intercellular Ca2+ signals. Adenosine Triphosphate 72-75 renin Rattus norvegicus 125-130 12623777-0 2003 Elevated dietary salt suppresses renin secretion but not thirst evoked by arterial hypotension in rats. Salts 17-21 renin Rattus norvegicus 33-38 12842861-5 2003 NaCl restriction elevated plasma renin and aldosterone concentration, whereas corticosterone was unaltered. Sodium Chloride 0-4 renin Rattus norvegicus 33-38 12913255-1 2003 The renin-angiotensin cascade plays an important role in blood pressure control and sodium homeostasis. Sodium 84-90 renin Rattus norvegicus 4-9 12821601-11 2003 We conclude that an impaired nitric oxide system might have a counterregulatory homeostatic role against the prohypertensive effects of thyroid hormone and that the renin-angiotensin system plays an important role in thyroxine+L-NAME hypertension. Thyroxine 217-226 renin Rattus norvegicus 165-170 12821601-11 2003 We conclude that an impaired nitric oxide system might have a counterregulatory homeostatic role against the prohypertensive effects of thyroid hormone and that the renin-angiotensin system plays an important role in thyroxine+L-NAME hypertension. NG-Nitroarginine Methyl Ester 227-233 renin Rattus norvegicus 165-170 12850396-1 2003 We have reported that the induction of diabetes in N(omega)-nitro-L-orginine methyl ester (L-NAME)-infused rats causes significant hypertension that is associated with increased plasma renin activity. n(omega)-nitro-l-orginine methyl ester 51-89 renin Rattus norvegicus 185-190 12850396-1 2003 We have reported that the induction of diabetes in N(omega)-nitro-L-orginine methyl ester (L-NAME)-infused rats causes significant hypertension that is associated with increased plasma renin activity. NG-Nitroarginine Methyl Ester 91-97 renin Rattus norvegicus 185-190 12817189-0 2003 Effects of angiotensin-(1-7) and other bioactive components of the renin-angiotensin system on vascular resistance and noradrenaline release in rat kidney. Norepinephrine 119-132 renin Rattus norvegicus 67-72 12623777-1 2003 Increased dietary salt intake was used as a nonpharmacological tool to blunt hypotension-induced increases in plasma renin activity (PRA) in order to evaluate the contribution of the renin-angiotensin system (RAS) to hypotension-induced thirst. Salts 18-22 renin Rattus norvegicus 117-122 12956256-1 2003 The interaction between the renin-angiotensin system and nitric oxide (NO) is undeniable, but its nature is not fully known. Nitric Oxide 57-69 renin Rattus norvegicus 28-33 12798820-10 2003 Plasma renin activity was upregulated by ramipril or ramipril plus furosemide but not influenced by infarction or furosemide alone. Ramipril 41-49 renin Rattus norvegicus 7-12 12798820-10 2003 Plasma renin activity was upregulated by ramipril or ramipril plus furosemide but not influenced by infarction or furosemide alone. Ramipril 53-61 renin Rattus norvegicus 7-12 12798820-10 2003 Plasma renin activity was upregulated by ramipril or ramipril plus furosemide but not influenced by infarction or furosemide alone. Furosemide 67-77 renin Rattus norvegicus 7-12 12798820-10 2003 Plasma renin activity was upregulated by ramipril or ramipril plus furosemide but not influenced by infarction or furosemide alone. Furosemide 114-124 renin Rattus norvegicus 7-12 12955794-0 2003 Renin-angiotensin system function and blood pressure in adult rats after perinatal salt overload. Salts 83-87 renin Rattus norvegicus 0-5 12955794-14 2003 In addition, high salt diet during the perinatal period induced renin-angiotensin system functional disturbances in the offspring. Salts 18-22 renin Rattus norvegicus 64-69 12621527-0 2003 The effect of isoprenaline infusion on renal renin and angiotensinogen gene expression in the anaesthetised rat. Isoproterenol 14-26 renin Rattus norvegicus 45-50 12560203-7 2003 Inhibition of angiotensin AT(1) receptors by candesartan from postnatal day 1 to day 5 increased COX-2 mRNA (2.5-fold), protein, and distribution, renin mRNA (7-fold) and PRC (20- to 70-fold), but had no influence on COX-1 mRNA. candesartan 45-56 renin Rattus norvegicus 147-152 14511073-2 2003 The prolonged infusion of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), a non-selective antagonist of adenosine receptors, induces hypertension, an increase in plasma renin activity and morphological cardiovascular changes. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 26-60 renin Rattus norvegicus 165-170 14511073-2 2003 The prolonged infusion of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), a non-selective antagonist of adenosine receptors, induces hypertension, an increase in plasma renin activity and morphological cardiovascular changes. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 62-67 renin Rattus norvegicus 165-170 12682080-8 2003 These data suggest that (1) restitution of normal renin control mechanisms by chromosomal transfer contributes to the recovery of dilator responses in SS.BN13 rats versus Dahl S rats but does not affect constrictor responses to oxygen, and (2) factors in the Dahl S genetic background contribute to an enhanced sensitivity of arterioles to elevated PO2 independent of elevated blood pressure. PO-2 349-352 renin Rattus norvegicus 50-55 12511427-1 2003 Activation of the renin-angiotensin system in the brain is considered important in the arousal and expression of sodium appetite. Sodium 113-119 renin Rattus norvegicus 18-23 12511427-7 2003 When the rats were tested with a concentration range of NaCl, however, after renin the average responses to the hypertonic 0.3 and 1.0 M stimuli were reduced to 74 and 70%, respectively, compared with those after vehicle injections. Sodium Chloride 56-60 renin Rattus norvegicus 77-82 12429553-10 2003 A low-salt diet induced a significant increase in plasma renin activity, which was partially inhibited by treatment with NS-398. Salts 6-10 renin Rattus norvegicus 57-62 12429553-10 2003 A low-salt diet induced a significant increase in plasma renin activity, which was partially inhibited by treatment with NS-398. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 121-127 renin Rattus norvegicus 57-62 12621527-7 2003 The increase in renal renin gene expression in response to isoprenaline was probably due primarily to the intracellular signalling processes acting directly on nuclear mechanisms. Isoproterenol 59-71 renin Rattus norvegicus 22-27 12621527-9 2003 These findings provide evidence that catecholamines are involved in mechanisms that rapidly alter the expression of the genes of the renin-angiotensin system within the kidney. Catecholamines 37-51 renin Rattus norvegicus 133-138 12621527-1 2003 In this study, we investigated the ability of acute infusions of isoprenaline to alter renin and angiotensinogen gene expression in the kidney of rats anaesthetised with chloralose-urethane. Isoproterenol 65-77 renin Rattus norvegicus 87-92 12621529-8 2003 In both experiments, the plasma renin activity (PRA) was significantly inhibited in the Salt groups and suppressed in the DOCA groups. Sodium Chloride 88-92 renin Rattus norvegicus 32-37 12621529-8 2003 In both experiments, the plasma renin activity (PRA) was significantly inhibited in the Salt groups and suppressed in the DOCA groups. Desoxycorticosterone Acetate 122-126 renin Rattus norvegicus 32-37 12621527-6 2003 The isoprenaline-induced renin secretion could have been mediated via the activation of beta-adrenoceptors resulting in the exocytosis of renin-containing granules, with a smaller contribution being due to reduced renal haemodynamics. Isoproterenol 4-16 renin Rattus norvegicus 25-30 12621527-6 2003 The isoprenaline-induced renin secretion could have been mediated via the activation of beta-adrenoceptors resulting in the exocytosis of renin-containing granules, with a smaller contribution being due to reduced renal haemodynamics. Isoproterenol 4-16 renin Rattus norvegicus 138-143 12674220-0 2003 Enhanced food and water intake in renin transgenic rats. Water 18-23 renin Rattus norvegicus 34-39 12644905-7 2003 Plasma renin activity (PRA) was further stimulated by fonsartan and losartan treatment. Losartan 68-76 renin Rattus norvegicus 7-12 12600921-3 2003 However, the mechanisms underlying superoxide production in low-renin hypertension are undefined. Superoxides 35-45 renin Rattus norvegicus 64-69 12573807-2 2003 Water deprivation significantly increased plasma renin activity (PRA), plasma Angiotensin II (AII), vasopressin (AVP), epinephrine, aldosterone and corticosterone concentrations but did not modify the plasma adrenocorticotropin hormone (ACTH) level. Water 0-5 renin Rattus norvegicus 49-54 12624004-6 2003 Flutamide treatment significantly reduced plasma renin concentrations and rat renin mRNA in kidney but not plasma angiotensinogen levels. Flutamide 0-9 renin Rattus norvegicus 49-54 12624004-6 2003 Flutamide treatment significantly reduced plasma renin concentrations and rat renin mRNA in kidney but not plasma angiotensinogen levels. Flutamide 0-9 renin Rattus norvegicus 78-83 12600921-2 2003 Vascular superoxide level is also increased in deoxycorticosterone acetate (DOCA)-salt hypertension, which is associated with a markedly depressed plasma renin activity because of sodium retention. Superoxides 9-19 renin Rattus norvegicus 154-159 12600921-2 2003 Vascular superoxide level is also increased in deoxycorticosterone acetate (DOCA)-salt hypertension, which is associated with a markedly depressed plasma renin activity because of sodium retention. Desoxycorticosterone Acetate 47-74 renin Rattus norvegicus 154-159 12574082-1 2003 Renin-angiotensin-aldosterone system blockade has been shown to protect against renal damage in salt-supplemented, stroke-prone spontaneously hypertensive rats (SHRsp). Salts 96-100 renin Rattus norvegicus 0-5 12600921-2 2003 Vascular superoxide level is also increased in deoxycorticosterone acetate (DOCA)-salt hypertension, which is associated with a markedly depressed plasma renin activity because of sodium retention. Desoxycorticosterone Acetate 76-80 renin Rattus norvegicus 154-159 12600921-2 2003 Vascular superoxide level is also increased in deoxycorticosterone acetate (DOCA)-salt hypertension, which is associated with a markedly depressed plasma renin activity because of sodium retention. Salts 82-86 renin Rattus norvegicus 154-159 12600921-2 2003 Vascular superoxide level is also increased in deoxycorticosterone acetate (DOCA)-salt hypertension, which is associated with a markedly depressed plasma renin activity because of sodium retention. Sodium 180-186 renin Rattus norvegicus 154-159 12644301-1 2003 Chronic stimulation of the renin-angiotensin system results in increased zona glomerulosa cells and in cells expressing the final enzyme in the synthesis of aldosterone, the cytochrome P-450 aldosterone synthase. Aldosterone 157-168 renin Rattus norvegicus 27-32 12574082-8 2003 These data show that protection by renin-angiotensin-aldosterone system blockade in this model is BP-dependent and mediated by preventing the severe increases in BP seen in untreated salt-supplemented SHRsp and further underscore the limitations of interpretations based on conventional tail-cuff BP measurements. Salts 183-187 renin Rattus norvegicus 35-40 12469222-0 2003 Renin mRNA expression and renal dysfunction in tacrolimus-induced acute nephrotoxicity. Tacrolimus 47-57 renin Rattus norvegicus 0-5 12388456-5 2003 In contrast, plasma aldosterone did not change or increased after drinking; plasma renin activity was elevated by water restriction and increased further after drinking. Water 114-119 renin Rattus norvegicus 83-88 12548095-14 2003 Restoration of arterial baroreflex function, decrease in BPV, and blockade of activated renin-angiotensin system may contribute to the organ protective action of candesartan in SAD rats. candesartan 162-173 renin Rattus norvegicus 88-93 12469222-4 2003 The purpose of this study was to elucidate the role of renin-angiotensin system (RAS) in tacrolimus-induced acute nephrotoxicity. Tacrolimus 89-99 renin Rattus norvegicus 55-60 12469222-5 2003 We examined the renal mRNA levels of renin in order to elucidate the relationship between plasma renin activity (PRA) and tacrolimus-induced renal dysfunction. Tacrolimus 122-132 renin Rattus norvegicus 37-42 12469222-5 2003 We examined the renal mRNA levels of renin in order to elucidate the relationship between plasma renin activity (PRA) and tacrolimus-induced renal dysfunction. Tacrolimus 122-132 renin Rattus norvegicus 97-102 12469222-8 2003 Renin mRNA levels in the renal cortex in tacrolimus treated rats significantly increased when compared to the vehicle-treated rats. Tacrolimus 41-51 renin Rattus norvegicus 0-5 12495295-0 2002 The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury. Cholesterol 44-55 renin Rattus norvegicus 16-21 12646409-1 2003 Nitric oxide (NO) regulates renin secretion through various pathways. Nitric Oxide 0-12 renin Rattus norvegicus 28-33 12646409-3 2003 In six Inactin-anesthetized rats, renin secretion rate (RSR) was measured in response to the beta-agonist isoproterenol with and without selective inhibition of nNOS using 7-nitroindazole (7-NI, 50 mg/kg body weight [BW]). Isoproterenol 106-119 renin Rattus norvegicus 34-39 12495295-0 2002 The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury. Puromycin 60-69 renin Rattus norvegicus 16-21 12445579-1 2002 The renin-angiotensin system may be involved in hypertension induced by adenosine receptors blockade with 1,3-dipropyl-8-sulfophenylxanthine (DPSPX). 1,3-dipropyl-8-(4-sulfophenyl)xanthine 106-140 renin Rattus norvegicus 4-9 12427159-2 2002 The present study determined the usefulness of modified periodic acid silver-methenamine (PAM) staining for the specific detection of Ren-1 renin. periodic acid silver-methenamine 56-88 renin Rattus norvegicus 140-145 12427159-2 2002 The present study determined the usefulness of modified periodic acid silver-methenamine (PAM) staining for the specific detection of Ren-1 renin. pam 90-93 renin Rattus norvegicus 140-145 12427159-9 2002 Immunohistochemistry using mirror sections suggested that a W-PAM-positive reaction detected renin. w-pam 60-65 renin Rattus norvegicus 93-98 12427159-11 2002 Briefly, W-PAM detected an expansion of renin-positive areas in AT1aKO mice. w-pam 9-14 renin Rattus norvegicus 40-45 12427159-14 2002 CONCLUSIONS: The present findings show that W-PAM can identify Ren-1 renin, but not Ren-2, rat or human renin. w-pam 44-49 renin Rattus norvegicus 63-68 12427159-14 2002 CONCLUSIONS: The present findings show that W-PAM can identify Ren-1 renin, but not Ren-2, rat or human renin. w-pam 44-49 renin Rattus norvegicus 69-74 12427159-15 2002 The W-PAM method is useful for the specific detection of Ren-1 renin. w-pam 4-9 renin Rattus norvegicus 63-68 12527027-7 2002 Thirst and VP secretion in rats each are stimulated by acute arterial hypotension, albeit not by the same signals; water intake is mediated by activation of the renin-angiotensin system but not by a neural signal from arterial baroreceptors, whereas the reverse may be true for the stimulation of VP secretion. Water 115-120 renin Rattus norvegicus 161-166 12445579-1 2002 The renin-angiotensin system may be involved in hypertension induced by adenosine receptors blockade with 1,3-dipropyl-8-sulfophenylxanthine (DPSPX). 1,3-dipropyl-8-(4-sulfophenyl)xanthine 142-147 renin Rattus norvegicus 4-9 12372791-2 2002 The resultant increase in NaCl delivery to the macula densa suppresses renin release. Sodium Chloride 26-30 renin Rattus norvegicus 71-76 12372791-13 2002 We conclude that the responses to acute hypertension, including diuresis and redistribution of PT NHE3 into intracellular membranes, require a responsive renin-angiotensin system and that the responses may be induced by the sustained increase in NaCl delivery to the macula densa during acute hypertension. Sodium Chloride 246-250 renin Rattus norvegicus 154-159 12625192-12 2002 Additionally, plasma renin activity (PRA) was highest in the 2K-1C group and lowest in the DOCA group. Desoxycorticosterone Acetate 91-95 renin Rattus norvegicus 21-26 12411476-1 2002 It is well established that renin-angiotensin system blockers exert NO/prostacyclin-dependent antithrombotic effects. Epoprostenol 71-83 renin Rattus norvegicus 28-33 12411476-7 2002 Thus, the antithrombotic effect of renin-angiotensin system blockers involves Ang-(1-7)-evoked release of NO and prostacyclin. Epoprostenol 113-125 renin Rattus norvegicus 35-40 12484518-5 2002 Increased plasma renin activity (23 +/- 8 ng/kg/h (n = 6) vs. sham operation, 2.4 +/- 0.9 ng/kg/h (n = 4)) was markedly reduced to 6.8 +/- 2.7 ng/ml/h (n = 5) by NS-398, but not by mofezolac. Nitrogen 162-164 renin Rattus norvegicus 17-22 12484518-5 2002 Increased plasma renin activity (23 +/- 8 ng/kg/h (n = 6) vs. sham operation, 2.4 +/- 0.9 ng/kg/h (n = 4)) was markedly reduced to 6.8 +/- 2.7 ng/ml/h (n = 5) by NS-398, but not by mofezolac. mofezolac 181-190 renin Rattus norvegicus 17-22 12484518-8 2002 In a deoxycorticosterone acetate (DOCA)-salt model, plasma renin activity was markedly suppressed to less than 0.3 ng/ml/h. Desoxycorticosterone Acetate 5-32 renin Rattus norvegicus 59-64 12484518-8 2002 In a deoxycorticosterone acetate (DOCA)-salt model, plasma renin activity was markedly suppressed to less than 0.3 ng/ml/h. Desoxycorticosterone Acetate 34-38 renin Rattus norvegicus 59-64 12484518-8 2002 In a deoxycorticosterone acetate (DOCA)-salt model, plasma renin activity was markedly suppressed to less than 0.3 ng/ml/h. Salts 40-44 renin Rattus norvegicus 59-64 12239231-8 2002 Moreover, our data suggest that the stimulation of the renin system by low salt and by ACE inhibitors is not essentially mediated by COX-2 activity. Salts 75-79 renin Rattus norvegicus 55-60 12419641-0 2002 Upregulation of vascular renin-angiotensin and endothelin systems in rats inhibited of nitric oxide synthesis. Nitric Oxide 87-99 renin Rattus norvegicus 25-30 12419641-1 2002 The present study was aimed at investigating whether the regulation of vascular renin-angiotensin and endothelin (ET) systems is altered by a chronic blockade of nitric oxide (NO) synthesis. Nitric Oxide 162-174 renin Rattus norvegicus 80-85 12434137-1 2002 COX-2-derived prostaglandins (PG) have been suggested to be important modulators of renin release and expression. Prostaglandins 14-28 renin Rattus norvegicus 84-89 12434137-1 2002 COX-2-derived prostaglandins (PG) have been suggested to be important modulators of renin release and expression. Prostaglandins 30-32 renin Rattus norvegicus 84-89 12434137-3 2002 In the present studies we explored the role of COX-2-derived PG on basal and angiotensin converting enzyme inhibitor (ACEI)-stimulated plasma and renal renin concentrations (PRC and RRC, RIA), and mRNA expression (RmRNA, RNAse protection assay) in experimental diabetes (DM). Prostaglandins 61-63 renin Rattus norvegicus 152-157 12364856-0 2002 Magnesium supplementation prevents experimental chronic cyclosporine a nephrotoxicity via renin-angiotensin system independent mechanism. Magnesium 0-9 renin Rattus norvegicus 90-95 12359983-0 2002 Neuronal nitric oxide synthase and renin stimulation by sodium deprivation are dependent on the renal nerves. Sodium 56-62 renin Rattus norvegicus 35-40 12359983-10 2002 CONCLUSION: The renal nerves mediate the increase of renin and nNOS mRNA during sodium restriction, while the suppression of nNOS and renin gene expression during a sodium load is independent of the presence of the renal nerves. Sodium 80-86 renin Rattus norvegicus 53-58 12359983-11 2002 The parallel changes in renin and nNOS mRNA during different sodium intakes suggest that nNOS can be part of the complex, and still largely unclarified, macula densa mechanism of renin regulation. Sodium 61-67 renin Rattus norvegicus 179-184 12219871-1 2002 BACKGROUND: Diets high in carbohydrates are associated with hypertension, activation of the renin-angiotensin system, hyperinsulinemia, insulin resistance, and renal dysfunction. Carbohydrates 26-39 renin Rattus norvegicus 92-97 12219871-2 2002 This study tests the hypothesis that the initial effect of a long-term high carbohydrate diet is a renin-angiotensin system dependant impairment of renal function. Carbohydrates 76-88 renin Rattus norvegicus 99-104 12126985-2 2002 Intragastric sodium load increased plasma sodium concentration and osmolality by 5% and reduced plasma renin activity by half compared to rats that received intragastric load of water. Sodium 13-19 renin Rattus norvegicus 103-108 12110513-0 2002 Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake. Prostaglandins 8-19 renin Rattus norvegicus 41-46 12110513-0 2002 Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake. Salts 81-85 renin Rattus norvegicus 41-46 12110513-1 2002 We investigated the effect of cyclooxygenase (COX) activity on the regulation of the renin-angiotensin-aldosterone system by salt intake. Salts 125-129 renin Rattus norvegicus 85-90 12110513-5 2002 In contrast, ketorolac delayed the increase in plasma renin activity and of renin mRNA in response to low salt intake but did not change plasma aldosterone concentration. Ketorolac 13-22 renin Rattus norvegicus 54-59 12110513-5 2002 In contrast, ketorolac delayed the increase in plasma renin activity and of renin mRNA in response to low salt intake but did not change plasma aldosterone concentration. Ketorolac 13-22 renin Rattus norvegicus 76-81 12110513-5 2002 In contrast, ketorolac delayed the increase in plasma renin activity and of renin mRNA in response to low salt intake but did not change plasma aldosterone concentration. Salts 106-110 renin Rattus norvegicus 54-59 12110513-5 2002 In contrast, ketorolac delayed the increase in plasma renin activity and of renin mRNA in response to low salt intake but did not change plasma aldosterone concentration. Salts 106-110 renin Rattus norvegicus 76-81 12110513-7 2002 These findings suggest that COX-1-derived, but not COX-2-derived, prostanoids are of relevance for the regulation of the renin system by salt intake. Prostaglandins 66-77 renin Rattus norvegicus 121-126 12110513-7 2002 These findings suggest that COX-1-derived, but not COX-2-derived, prostanoids are of relevance for the regulation of the renin system by salt intake. Salts 137-141 renin Rattus norvegicus 121-126 12184998-0 2002 Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. Prostaglandins 0-14 renin Rattus norvegicus 29-34 12184998-8 2002 Captopril administration increased renin equally [plasma renin activity (PRA): +/+ 9.3 +/- 2.2 vs. 50.1 +/- 10.9; -/- 13.7 +/- 1.5 vs. 43.9 +/- 6.6 ng ANG I x ml(-1) x h(-1); renal renin concentration: +/+ 11.8 +/- 1.7 vs. 35.3 +/- 3.9; -/- 13.0 +/- 3.0 vs. 27.8 +/- 2.7 ng ANG I x mg protein(-1) x h(-1); n = 6; P < 0.05 with or without captopril]. Captopril 0-9 renin Rattus norvegicus 35-40 12184998-8 2002 Captopril administration increased renin equally [plasma renin activity (PRA): +/+ 9.3 +/- 2.2 vs. 50.1 +/- 10.9; -/- 13.7 +/- 1.5 vs. 43.9 +/- 6.6 ng ANG I x ml(-1) x h(-1); renal renin concentration: +/+ 11.8 +/- 1.7 vs. 35.3 +/- 3.9; -/- 13.0 +/- 3.0 vs. 27.8 +/- 2.7 ng ANG I x mg protein(-1) x h(-1); n = 6; P < 0.05 with or without captopril]. Captopril 0-9 renin Rattus norvegicus 57-62 12184998-8 2002 Captopril administration increased renin equally [plasma renin activity (PRA): +/+ 9.3 +/- 2.2 vs. 50.1 +/- 10.9; -/- 13.7 +/- 1.5 vs. 43.9 +/- 6.6 ng ANG I x ml(-1) x h(-1); renal renin concentration: +/+ 11.8 +/- 1.7 vs. 35.3 +/- 3.9; -/- 13.0 +/- 3.0 vs. 27.8 +/- 2.7 ng ANG I x mg protein(-1) x h(-1); n = 6; P < 0.05 with or without captopril]. Captopril 0-9 renin Rattus norvegicus 57-62 12184998-11 2002 The COX-2 inhibitor SC-58236 blocked ACEI-induced elevation in renal renin concentration in EP(2) null mice (+/+ 24.7 +/- 1.7 vs. 9.8 +/- 0.4; -/- 21.1 +/- 3.2 vs. 9.3 +/- 0.4 ng ANG I x mg protein(-1) x h(-1); n = 5) as well as in COX-1 -/- mice (SC-58236-treated PRA: +/+ 7.3 +/- 0.6; -/- 8.0 +/- 0.9 ng ANG I x ml(-1) x h(-1); renal renin: +/+ 9.1 +/- 0.9; -/- 9.6 +/- 0.5 ng ANG I x mg protein(-1) x h(-1); n = 6-7; P < 0.05 compared with no treatment). 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 20-28 renin Rattus norvegicus 69-74 12184998-11 2002 The COX-2 inhibitor SC-58236 blocked ACEI-induced elevation in renal renin concentration in EP(2) null mice (+/+ 24.7 +/- 1.7 vs. 9.8 +/- 0.4; -/- 21.1 +/- 3.2 vs. 9.3 +/- 0.4 ng ANG I x mg protein(-1) x h(-1); n = 5) as well as in COX-1 -/- mice (SC-58236-treated PRA: +/+ 7.3 +/- 0.6; -/- 8.0 +/- 0.9 ng ANG I x ml(-1) x h(-1); renal renin: +/+ 9.1 +/- 0.9; -/- 9.6 +/- 0.5 ng ANG I x mg protein(-1) x h(-1); n = 6-7; P < 0.05 compared with no treatment). 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 20-28 renin Rattus norvegicus 336-341 12195126-14 2002 Measurement of plasma renin activity, which was suppressed and stimulated, respectively, by high and low sodium intake, indicated that the effects on SBP and renal function induced by ICV RU28318 were independent from the level of activation of the renin-angiotensin system. Sodium 105-111 renin Rattus norvegicus 22-27 12195126-14 2002 Measurement of plasma renin activity, which was suppressed and stimulated, respectively, by high and low sodium intake, indicated that the effects on SBP and renal function induced by ICV RU28318 were independent from the level of activation of the renin-angiotensin system. RU 28318 188-195 renin Rattus norvegicus 22-27 12010742-10 2002 We conclude that the expression of renin, COX-2, and nNOS in the juxtaglomerular apparatus during low-salt diet is markedly limited by a direct feedback inhibition through ANG II. Salts 102-106 renin Rattus norvegicus 35-40 12146504-3 2002 Herein, physiological changes in the endogenous level of activity of the renin-angiotensin system were produced by alterations in the dietary sodium intake. Sodium 142-148 renin Rattus norvegicus 73-78 12146504-4 2002 Microinjection of the angiotensin II AT1 receptor antagonists losartan or candesartan into the rostral ventrolateral medulla produced the bradycardic, depressor and renal sympathoinhibitory responses which were greater in low sodium diet rats with stimulated activity of the renin-angiotensin system than in high sodium diet rats with suppressed activity of the renin-angiotensin system activity. Losartan 62-70 renin Rattus norvegicus 275-280 12146504-4 2002 Microinjection of the angiotensin II AT1 receptor antagonists losartan or candesartan into the rostral ventrolateral medulla produced the bradycardic, depressor and renal sympathoinhibitory responses which were greater in low sodium diet rats with stimulated activity of the renin-angiotensin system than in high sodium diet rats with suppressed activity of the renin-angiotensin system activity. Losartan 62-70 renin Rattus norvegicus 362-367 12146504-4 2002 Microinjection of the angiotensin II AT1 receptor antagonists losartan or candesartan into the rostral ventrolateral medulla produced the bradycardic, depressor and renal sympathoinhibitory responses which were greater in low sodium diet rats with stimulated activity of the renin-angiotensin system than in high sodium diet rats with suppressed activity of the renin-angiotensin system activity. candesartan 74-85 renin Rattus norvegicus 275-280 12146504-4 2002 Microinjection of the angiotensin II AT1 receptor antagonists losartan or candesartan into the rostral ventrolateral medulla produced the bradycardic, depressor and renal sympathoinhibitory responses which were greater in low sodium diet rats with stimulated activity of the renin-angiotensin system than in high sodium diet rats with suppressed activity of the renin-angiotensin system activity. candesartan 74-85 renin Rattus norvegicus 362-367 12213258-9 2002 Injecting 8-OH-DPAT to saline pretreated rats produced a significant increase in plasma oxytocin (299%), ACTH (1456%) and corticosterone (170%) levels but not in plasma prolactin or renin concentrations. Sodium Chloride 23-29 renin Rattus norvegicus 182-187 12806161-10 2002 These data indicate that nebivolol prevents the development of the arterial hypertension associated with chronic NO deficit and this effect seems to be dependent on the inhibition of renin-angiotensin system. Nebivolol 25-34 renin Rattus norvegicus 183-188 12010742-1 2002 Salt restriction leads to parallel increases of renin, cyclooxygenase-2 (COX-2), and neuronal nitric oxide synthase (nNOS) gene expression in the juxtaglomerular apparatus of rat kidneys. Salts 0-4 renin Rattus norvegicus 48-53 12010742-2 2002 Because the upregulation of these genes is strongly enhanced if salt restriction is combined with inhibition of the renin-angiotensin-aldosterone system, our study aimed to find out whether the juxtaglomerular expressions of renin, COX-2, and nNOS are subject to a common direct negative feedback control by ANG II. Salts 64-68 renin Rattus norvegicus 225-230 12010742-6 2002 Although fludrocortisone had no effect on basal renin, COX-2, and nNOS mRNA, it clearly attenuated the threefold increases of both renin and COX-2 mRNA in response to low-salt diet. Fludrocortisone 9-24 renin Rattus norvegicus 131-136 12010742-6 2002 Although fludrocortisone had no effect on basal renin, COX-2, and nNOS mRNA, it clearly attenuated the threefold increases of both renin and COX-2 mRNA in response to low-salt diet. Salts 171-175 renin Rattus norvegicus 131-136 12010742-7 2002 In rats on low-salt diet, ramipril further increased renin mRNA ninefold, COX-2 mRNA fourfold, and nNOS 2.5-fold in the absence of fludrocortisone. Ramipril 26-34 renin Rattus norvegicus 53-58 12010742-8 2002 In the presence of fludrocortisone, ramipril increased renin mRNA 10-fold, COX-2 mRNA 2.5-fold, and nNOS mRNA 2.5-fold. Fludrocortisone 19-34 renin Rattus norvegicus 55-60 12010742-8 2002 In the presence of fludrocortisone, ramipril increased renin mRNA 10-fold, COX-2 mRNA 2.5-fold, and nNOS mRNA 2.5-fold. Ramipril 36-44 renin Rattus norvegicus 55-60 12010742-9 2002 These data indicate that mineralocorticoid substitution lowers the overall expression of juxtaglomerular renin and COX-2 during low-salt intake and attenuates a further rise of COX-2 expression by ACE inhibition, but it does not change the stimulatory effect of ACE inhibition on renin and nNOS expression. Salts 132-136 renin Rattus norvegicus 105-110 11906319-7 2002 Plasma renin and aldosterone concentrations and ACE activity decreased with increasing dietary sodium. Sodium 95-101 renin Rattus norvegicus 7-12 12052845-5 2002 After 7 weeks, untreated Dahl salt-sensitive rats were characterized by decreased kidney function, abnormal morphological findings, increased hormone levels, increased renal tissue angiotensin II levels, and altered mRNA expressions of transforming growth factor beta (TGF-beta) and components of the renin-angiotensin system compared with Dahl salt-resistant rats. dahl salt 25-34 renin Rattus norvegicus 301-306 12023680-13 2002 We verified our results by selecting a high-salt downregulated gene (renin) and an upregulated gene (B7 antigen) and subjecting these genes to real-time polymerase chain reaction. Salts 44-48 renin Rattus norvegicus 69-74 12016266-0 2002 Control of renin secretion from rat juxtaglomerular cells by cAMP-specific phosphodiesterases. Cyclic AMP 61-65 renin Rattus norvegicus 11-16 12016266-1 2002 We tested the hypothesis that cGMP stimulates renin release through inhibition of the cAMP-specific phosphodiesterase 3 (PDE3) in isolated rat juxtaglomerular (JG) cells. Cyclic GMP 30-34 renin Rattus norvegicus 46-51 12016266-1 2002 We tested the hypothesis that cGMP stimulates renin release through inhibition of the cAMP-specific phosphodiesterase 3 (PDE3) in isolated rat juxtaglomerular (JG) cells. Cyclic AMP 86-90 renin Rattus norvegicus 46-51 12016266-3 2002 JG cells expressed PDE3A and PDE3B, and the PDE3 inhibitor trequinsin increased cellular cAMP content, enhanced forskolin-induced cAMP formation, and stimulated renin release from incubated and superfused JG cells. trequinsin 59-69 renin Rattus norvegicus 161-166 12016266-4 2002 Trequinsin-mediated stimulation of renin release was inhibited by the permeable protein kinase A antagonist Rp-8-CPT-cAMPS. trequinsin 0-10 renin Rattus norvegicus 35-40 12016266-11 2002 We conclude that degradation of cAMP by PDE3 and PDE4 contributes to regulation of renin release from JG cells. Cyclic AMP 32-36 renin Rattus norvegicus 83-88 12016266-12 2002 Our data provide evidence at the cellular level that stimulation of renin release by cGMP involves inhibition of PDE3 resulting in enhanced cAMP formation and activation of the cAMP sensitive protein kinase. Cyclic GMP 85-89 renin Rattus norvegicus 68-73 12016266-12 2002 Our data provide evidence at the cellular level that stimulation of renin release by cGMP involves inhibition of PDE3 resulting in enhanced cAMP formation and activation of the cAMP sensitive protein kinase. Cyclic AMP 140-144 renin Rattus norvegicus 68-73 12007926-2 2002 Adenosine inhibits noradrenaline and renin release. Adenosine 0-9 renin Rattus norvegicus 37-42 12007926-9 2002 Plasma renin activity was increased in DPSPX-treated animals. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 39-44 renin Rattus norvegicus 7-12 11893611-9 2002 These results suggest that the sympathetic nervous system may be involved in the hypertensive response to onset of diabetes in L-NAME-treated rats, possibly through control of renin secretion. NG-Nitroarginine Methyl Ester 127-133 renin Rattus norvegicus 176-181 11876576-0 2002 Interaction of cyclosporine A and the renin-angiotensin system; new perspectives. Cyclosporine 15-29 renin Rattus norvegicus 38-43 11832405-3 2002 Recent studies have indicated that bilateral injections of the serotonin receptor antagonist methysergide into the lateral parabrachial nucleus (LPBN) markedly increases salt intake in models involving the activation of the renin-angiotensin system or mineralocorticoid hormones. Methysergide 93-105 renin Rattus norvegicus 224-229 11832429-2 2002 Therefore, we determined the effects of renal denervation and the beta-adrenoreceptor antagonist metoprolol (50 mg/kg body wt po, twice a day) on renocortical expression of renin, COX-2, and nNOS in rats fed a low-salt (0.02% wt/wt) diet or treated for 1 wk with ramipril (10 mg/kg body wt) in combination with a low-salt diet. Metoprolol 97-107 renin Rattus norvegicus 173-178 11832429-3 2002 We found that a low-salt diet in combination with ramipril strongly increased renocortical mRNA levels of renin, COX-2, and nNOS 9-, 7-, and 2.5-fold, respectively. Salts 20-24 renin Rattus norvegicus 106-111 11832429-3 2002 We found that a low-salt diet in combination with ramipril strongly increased renocortical mRNA levels of renin, COX-2, and nNOS 9-, 7-, and 2.5-fold, respectively. Ramipril 50-58 renin Rattus norvegicus 106-111 11818241-3 2002 Prorenin free of renin was obtained after (NH4)2SO4 precipitation, gel filtration, and ion-exchange chromatography by a passage through an affinity gel of H-77 Sepharose. Ammonium Sulfate 42-51 renin Rattus norvegicus 3-8 11876576-2 2002 Several lines of evidence suggest an involvement of the renin-angiotensin system (RAS) in CsA toxicity, but the issue is still controversial in more ways than one. Cyclosporine 90-93 renin Rattus norvegicus 56-61 11818241-3 2002 Prorenin free of renin was obtained after (NH4)2SO4 precipitation, gel filtration, and ion-exchange chromatography by a passage through an affinity gel of H-77 Sepharose. Sepharose 160-169 renin Rattus norvegicus 3-8 11818241-4 2002 SDS-PAGE of supernatant and of acidic elution from gel, exhibited a single band of 43 kDa and 35 kDa, respectively; both recognized by the specific anti rat renin antibody. Sodium Dodecyl Sulfate 0-3 renin Rattus norvegicus 157-162 11876576-6 2002 CsA increases renin release directly from juxtaglomerular cells. Cyclosporine 0-3 renin Rattus norvegicus 14-19 12067101-0 2002 Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin system. Water 28-33 renin Rattus norvegicus 108-113 11796674-7 2002 Whole kidney renin mRNA was suppressed in high-salt controls and episodic hypoxia rats, whereas kidney AT(1a) mRNA showed opposite changes. Salts 47-51 renin Rattus norvegicus 13-18 11796674-8 2002 Suppression of the renin-angiotensin system with a high-salt diet blocks the increase in MAP in episodic hypoxia-challenged rats, in part by suppressing local tissue renin levels. Salts 56-60 renin Rattus norvegicus 19-24 11796674-8 2002 Suppression of the renin-angiotensin system with a high-salt diet blocks the increase in MAP in episodic hypoxia-challenged rats, in part by suppressing local tissue renin levels. Salts 56-60 renin Rattus norvegicus 166-171 11824863-0 2002 The renin-angiotensin and adrenergic nervous system in cardiac hypertrophy in fructose-fed rats. Fructose 78-86 renin Rattus norvegicus 4-9 11709406-0 2001 Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system. Isoproterenol 0-13 renin Rattus norvegicus 78-83 11805851-7 2002 Plasma renin and aldosterone concentrations decreased with increasing dietary sodium intake in both Control and L-NAME-treated rats. Sodium 78-84 renin Rattus norvegicus 7-12 11805851-7 2002 Plasma renin and aldosterone concentrations decreased with increasing dietary sodium intake in both Control and L-NAME-treated rats. NG-Nitroarginine Methyl Ester 112-118 renin Rattus norvegicus 7-12 11743222-4 2002 The inhibition of forskolin-induced renin secretion by endothelin-3 in primary cultures of mouse juxtaglomerular cells and by endothelin-1 in the isolated perfused rat kidney could not be blocked by naftidrofuryl. Colforsin 18-27 renin Rattus norvegicus 36-41 11743222-6 2002 In contrast, naftidrofuryl markedly attenuated serotonin-induced renal vasoconstriction and nearly completely blocked serotonin"s renin inhibitory properties in isolated perfused rat kidney. Nafronyl 13-26 renin Rattus norvegicus 130-135 11743222-6 2002 In contrast, naftidrofuryl markedly attenuated serotonin-induced renal vasoconstriction and nearly completely blocked serotonin"s renin inhibitory properties in isolated perfused rat kidney. Serotonin 118-127 renin Rattus norvegicus 130-135 12116903-2 2002 The aim of this study was to determine the effect of single and combined exposure to lead and cadmium at hypertensive doses on the tissue renin-angiotensin system in rats. Cadmium 94-101 renin Rattus norvegicus 138-143 12120004-2 2002 The activation of such a local renin-angiotensin system may provide an alternate mechanism that leads to the generation of reactive radical species in the pancreas during chronically hypoxic exposure. reactive radical species 123-147 renin Rattus norvegicus 31-36 11739278-4 2001 The mitogenic effect is blocked by 10(-6) mol/L losartan and by 1 micromol/L renin antisense phosphorothioate oligomers but not by 10(-6) mol/L candesartan. Parathion 93-109 renin Rattus norvegicus 77-82 11903126-1 2001 Nitric oxide (NO) produced by neuronal NO-synthase (nNOS) in macula densa cells may be involved in the control of renin release. Nitric Oxide 0-12 renin Rattus norvegicus 114-119 11903126-7 2001 Plasma renin concentration was stimulated in LS-rats (251 +/- 64 mGU mL(-1)) compared with C and HS rats (42 +/- 8 and 39 +/- 5 mGU mL(-1), respectively) but was not significantly affected by chronic 7-NI treatment (350 +/- 103, 49 +/- 10 and 50 +/- 15 mGU mL(-1) in LS, C and HS, respectively). 7-nitroindazole 200-204 renin Rattus norvegicus 7-12 12424424-3 2002 In view of the well-known fact that dietary salt restriction also leads to an activation of the renin-angiotensin system, the present study was performed to assess the role of nNOS-derived NO in the regulation of the renal function in rats maintained on control (C) and low-salt (LS) diets. Salts 44-48 renin Rattus norvegicus 96-101 11709406-8 2001 Isoproterenol increased plasma renin, ANG I, and ANG II three- to fourfold. Isoproterenol 0-13 renin Rattus norvegicus 31-36 11770086-11 2001 In conclusion, no evidence was found for myocardial renin synthesis in the normal adult rat heart, and myocardial renin decays to near zero levels after 48-hour BNX. benoxinate 161-164 renin Rattus norvegicus 114-119 11826965-2 2001 As a result, it was observed that acetic acid itself, the main component of vinegar, significantly reduced both blood pressure (p<0.05) and renin activity (p<0.01) compared to controls given no acetic acid or vinegar, as well as vinegar. Acetic Acid 34-45 renin Rattus norvegicus 143-148 11668076-0 2001 Role of renin-angiotensin-aldosterone system in salt-sensitive hypertension induced by sensory denervation. Salts 48-52 renin Rattus norvegicus 8-13 11724758-7 2001 The lowest dosages of both drugs had non-significant effects on blood pressure but inhibited the paradoxical increases in plasma renin activity (PRA) and in renin mRNA in kidney that were found in salt-loaded SHRSP. Salts 197-201 renin Rattus norvegicus 129-134 11724758-7 2001 The lowest dosages of both drugs had non-significant effects on blood pressure but inhibited the paradoxical increases in plasma renin activity (PRA) and in renin mRNA in kidney that were found in salt-loaded SHRSP. Salts 197-201 renin Rattus norvegicus 157-162 11724758-8 2001 The lowest dosage of lacidipine (but not of amlodipine) restored the physiological downregulation of renin production by high salt and reduced left ventricular hypertrophy and mRNA levels of atrial natriuretic factor and transforming growth factor-beta1. lacidipine 21-31 renin Rattus norvegicus 101-106 11724758-8 2001 The lowest dosage of lacidipine (but not of amlodipine) restored the physiological downregulation of renin production by high salt and reduced left ventricular hypertrophy and mRNA levels of atrial natriuretic factor and transforming growth factor-beta1. Salts 126-130 renin Rattus norvegicus 101-106 11592949-0 2001 Effects of all-trans retinoic acid on renin-angiotensin system in rats with experimental nephritis. Tretinoin 11-34 renin Rattus norvegicus 38-43 11557622-0 2001 Nitric oxide synthase and cGMP-mediated stimulation of renin secretion. Cyclic GMP 26-30 renin Rattus norvegicus 55-60 11677376-13 2001 In rats on 0.2% NaCl plasma renin rose dramatically with medication and angiotensinogen became depleted. Sodium Chloride 16-20 renin Rattus norvegicus 28-33 11677376-15 2001 CONCLUSION: Combined blockade of the renin-angiotensin system can cause death in rats on a reduced NaCl intake. Sodium Chloride 99-103 renin Rattus norvegicus 37-42 11703585-9 2001 Moreover, the COX-2 inhibitor rofecoxib dose-dependently attenuated diuresis and saluresis, as well as the stimulation of the renin system induced by furosemide. rofecoxib 30-39 renin Rattus norvegicus 126-131 11703585-9 2001 Moreover, the COX-2 inhibitor rofecoxib dose-dependently attenuated diuresis and saluresis, as well as the stimulation of the renin system induced by furosemide. Furosemide 150-160 renin Rattus norvegicus 126-131 11703585-10 2001 Furthermore, rofecoxib completely reversed diuresis and saluresis and prevented the increase of plasma renin activity induced by hydrochlorothiazide. rofecoxib 13-22 renin Rattus norvegicus 103-108 11703585-10 2001 Furthermore, rofecoxib completely reversed diuresis and saluresis and prevented the increase of plasma renin activity induced by hydrochlorothiazide. Hydrochlorothiazide 129-148 renin Rattus norvegicus 103-108 11557622-1 2001 The interaction between nitric oxide (NO) and renin is controversial. Nitric Oxide 24-36 renin Rattus norvegicus 46-51 11557622-2 2001 cAMP is a stimulating messenger for renin, which is degraded by phosphodiesterase (PDE)-3. Cyclic AMP 0-4 renin Rattus norvegicus 36-41 11557622-4 2001 We hypothesized that if endogenous cGMP was increased by inhibiting PDE-5, it could inhibit PDE-3, increasing endogenous cAMP, and thereby stimulate renin. Cyclic GMP 35-39 renin Rattus norvegicus 149-154 11557622-4 2001 We hypothesized that if endogenous cGMP was increased by inhibiting PDE-5, it could inhibit PDE-3, increasing endogenous cAMP, and thereby stimulate renin. Cyclic AMP 121-125 renin Rattus norvegicus 149-154 11557622-11 2001 Pretreatment with the nNOS inhibitor 7-nitroindazole (7-NI; 50 mg/kg body wt) did not change BP or RBF but attenuated the renin-stimulating effect of zaprinast by 40% compared with vehicle. 7-nitroindazole 37-52 renin Rattus norvegicus 122-127 11557622-11 2001 Pretreatment with the nNOS inhibitor 7-nitroindazole (7-NI; 50 mg/kg body wt) did not change BP or RBF but attenuated the renin-stimulating effect of zaprinast by 40% compared with vehicle. 7-nitroindazole 54-58 renin Rattus norvegicus 122-127 11557622-11 2001 Pretreatment with the nNOS inhibitor 7-nitroindazole (7-NI; 50 mg/kg body wt) did not change BP or RBF but attenuated the renin-stimulating effect of zaprinast by 40% compared with vehicle. zaprinast 150-159 renin Rattus norvegicus 122-127 11557622-13 2001 This suggests that changes in endogenous cGMP production at levels not associated with renal hemodynamic changes are involved in a renin-stimulatory pathway. Cyclic GMP 41-45 renin Rattus norvegicus 131-136 11488744-3 2001 Prostaglandins, thromboxanes and renin-angiotensin were inhibited pharmacologically using diclofenac sodium and enalapril. Diclofenac 90-107 renin Rattus norvegicus 33-38 11680616-6 2001 The stimulation of renin secretion by the low-salt diet but not by low salt plus ramipril was attenuated by rofecoxib. Salts 46-50 renin Rattus norvegicus 19-24 11680616-6 2001 The stimulation of renin secretion by the low-salt diet but not by low salt plus ramipril was attenuated by rofecoxib. rofecoxib 108-117 renin Rattus norvegicus 19-24 11680616-7 2001 The low-salt diet led to a moderate increase of renin gene expression, and additional treatment with ramipril caused a 15-fold increase of renin mRNA. Salts 8-12 renin Rattus norvegicus 48-53 11680616-7 2001 The low-salt diet led to a moderate increase of renin gene expression, and additional treatment with ramipril caused a 15-fold increase of renin mRNA. Ramipril 101-109 renin Rattus norvegicus 139-144 11680616-10 2001 COX-2-derived prostanoids may play a role in the regulation of renin secretion but not in renin gene expression during the intake of a low-salt diet. Prostaglandins 14-25 renin Rattus norvegicus 63-68 11531021-8 2001 6N-cyclopentyladenosine (CPA; selective A1 adenosine receptor agonist) induced bradicardia and negative inotropic effects, reduced work load (i.e., decreased HR, VPSP, +dP/dtmax, +dP/dtmax/VPSP and HR x VPSP) and inhibited endotoxin-induced tachycardia and renin release. 6n-cyclopentyladenosine 0-23 renin Rattus norvegicus 257-262 11531021-8 2001 6N-cyclopentyladenosine (CPA; selective A1 adenosine receptor agonist) induced bradicardia and negative inotropic effects, reduced work load (i.e., decreased HR, VPSP, +dP/dtmax, +dP/dtmax/VPSP and HR x VPSP) and inhibited endotoxin-induced tachycardia and renin release. cpa 25-28 renin Rattus norvegicus 257-262 11476744-9 2001 Bumetanide increased renin and aldosterone secretion whereas candoxatril decreased renin secretion. Bumetanide 0-10 renin Rattus norvegicus 21-26 11476744-9 2001 Bumetanide increased renin and aldosterone secretion whereas candoxatril decreased renin secretion. candoxatril 61-72 renin Rattus norvegicus 83-88 11476744-10 2001 This effect on renin release was associated with an increase in macula densa NADPH diaphorase activity in the bumetanide-treated group which was blunted by candoxatril. Bumetanide 110-120 renin Rattus norvegicus 15-20 11476744-10 2001 This effect on renin release was associated with an increase in macula densa NADPH diaphorase activity in the bumetanide-treated group which was blunted by candoxatril. candoxatril 156-167 renin Rattus norvegicus 15-20 11575208-0 2001 [Effect of a non-antihypertensive dose of ramipril on the plasma and tissue renin-angiotensin system in 27 TGR (mRen2) rats]. Ramipril 42-50 renin Rattus norvegicus 76-81 11575208-2 2001 The use of low dose of ramipril, an ACE inhibitor, make it possible to explore the place of cardiac renin-angiotensin system (RAS) in the regression of HVG independently of blood pressure (BP). Ramipril 23-31 renin Rattus norvegicus 100-105 11575208-10 2001 In plasma and kidney treatment"s effect on SRA is confirmed by the increase in renin activity (plasma: 63 +/- 9 vs 36 +/- 5 ng Ang I/mL/h; kidney: 127 +/- 11 vs 92 +/- 7 micrograms Ang I/g/h) which is accompanied by an increase of Ang I rates (plasma: 297 +/- 31 vs 15 +/- 10 fmol/mL; kidney: 241 +/- 37 vs 160 +/- 12 fmol/g) and of the reduction in Aogen. SRS-A 43-46 renin Rattus norvegicus 79-84 11604244-5 2001 Furthermore, renin mRNA but not angiotensin AT1 receptor mRNA levels were decreased in the hypothalamus of the antisense oligodeoxynucleotide-treated rats. Oligodeoxyribonucleotides 121-141 renin Rattus norvegicus 13-18 11532080-0 2001 Influence of the renin-angiotensin system on epidermal growth factor expression in normal and cyclosporine-treated rat kidney. Cyclosporine 94-106 renin Rattus norvegicus 17-22 11680613-2 2001 Therefore, we semi-quantitated renocortical renin and COX-2 gene expression when the renin-angiotensin system (RAS) was inhibited by the angiotensin II (Ang II) AT1 receptor antagonist candesartan (15 mg/kg per day) and when COX-2 activity was blocked by celecoxib (20 mg/kg twice a day) in three rat strains (Sprague-Dawley, WKY and SHR) at ages of 5, 9 and 15 weeks. candesartan 185-196 renin Rattus norvegicus 85-90 11680613-2 2001 Therefore, we semi-quantitated renocortical renin and COX-2 gene expression when the renin-angiotensin system (RAS) was inhibited by the angiotensin II (Ang II) AT1 receptor antagonist candesartan (15 mg/kg per day) and when COX-2 activity was blocked by celecoxib (20 mg/kg twice a day) in three rat strains (Sprague-Dawley, WKY and SHR) at ages of 5, 9 and 15 weeks. Celecoxib 255-264 renin Rattus norvegicus 85-90 11488744-3 2001 Prostaglandins, thromboxanes and renin-angiotensin were inhibited pharmacologically using diclofenac sodium and enalapril. Enalapril 112-121 renin Rattus norvegicus 33-38 11512025-1 2001 The intracellular free calcium concentration ([Ca2+]i) is a central regulator of renin secretion and the contractility of vascular smooth muscle cells. Calcium 23-30 renin Rattus norvegicus 81-86 11473654-8 2001 Compared with fosinopril, omapatrilat treatment was associated with increased plasma renin activity and decreased renal ACE and NEP binding in a dose-dependent manner. omapatrilat 26-37 renin Rattus norvegicus 85-90 11512025-6 2001 Also renin secretion that was pre-stimulated by isoproterenol (10 nM), blockade of macula densa salt transport by bumetanide (100 microM) or lowering the perfusion pressure to 40 mmHg was not attenuated by Na+/Ca2+-exchanger inhibition, although the vascular resistance increased significantly. Isoproterenol 48-61 renin Rattus norvegicus 5-10 11508345-0 2001 Role of plasma renin activity and the renal nerves in the natriuresis of L-NMMA infusion in rats. omega-N-Methylarginine 73-79 renin Rattus norvegicus 15-20 12575579-6 2001 RESULTS: Chronic CsA-induced nephropathy might be correlated to TGF-beta 1 and renin mRNA up-regulation as well as matric proteins accumulation in interstitium. Cyclosporine 17-20 renin Rattus norvegicus 79-84 12575579-8 2001 CONCLUSION: Decreased CsA-related TGF-beta 1 and renin upregulation expression and accumulation of matrix proteins in the kidney might be related to the protective mechanism of CSI on CsA-induced chronic nephrotoxicity. Cyclosporine 22-25 renin Rattus norvegicus 49-54 12575579-8 2001 CONCLUSION: Decreased CsA-related TGF-beta 1 and renin upregulation expression and accumulation of matrix proteins in the kidney might be related to the protective mechanism of CSI on CsA-induced chronic nephrotoxicity. Cyclosporine 184-187 renin Rattus norvegicus 49-54 11508345-1 2001 The objective of this study was to determine the effect of N(G)-monomethyl-L-arginine (L-NMMA) infusion on plasma renin activity (PRA) in the presence or absence of the renal nerves in normotensive Wistar-Kyoto (WKY) rats and Okamoto spontaneously hypertensive rats (SHR). omega-N-Methylarginine 59-85 renin Rattus norvegicus 114-119 11508345-1 2001 The objective of this study was to determine the effect of N(G)-monomethyl-L-arginine (L-NMMA) infusion on plasma renin activity (PRA) in the presence or absence of the renal nerves in normotensive Wistar-Kyoto (WKY) rats and Okamoto spontaneously hypertensive rats (SHR). omega-N-Methylarginine 87-93 renin Rattus norvegicus 114-119 11446717-7 2001 Renin gene expression significantly increased in rats fed with the low sodium diet compared with the standard diet group, and significantly decreased in rats fed the high sodium diet Renal denervation significantly reduced renin mRNA levels in rats receiving the low sodium diet, but did not produce any significant change in normal or high-sodium groups. Sodium 71-77 renin Rattus norvegicus 0-5 11508274-1 2001 AIMS/HYPOTHESIS: The results of the EUCLID trial (EURODIAB Controlled Trial of Lisinopril in Insulin-dependent Diabetes Mellitus) highlighted the importance of the renin-angiotensin system in the pathogenesis of diabetic retinopathy. Lisinopril 79-89 renin Rattus norvegicus 164-169 11446717-7 2001 Renin gene expression significantly increased in rats fed with the low sodium diet compared with the standard diet group, and significantly decreased in rats fed the high sodium diet Renal denervation significantly reduced renin mRNA levels in rats receiving the low sodium diet, but did not produce any significant change in normal or high-sodium groups. Sodium 171-177 renin Rattus norvegicus 0-5 11446717-7 2001 Renin gene expression significantly increased in rats fed with the low sodium diet compared with the standard diet group, and significantly decreased in rats fed the high sodium diet Renal denervation significantly reduced renin mRNA levels in rats receiving the low sodium diet, but did not produce any significant change in normal or high-sodium groups. Sodium 171-177 renin Rattus norvegicus 0-5 11446717-7 2001 Renin gene expression significantly increased in rats fed with the low sodium diet compared with the standard diet group, and significantly decreased in rats fed the high sodium diet Renal denervation significantly reduced renin mRNA levels in rats receiving the low sodium diet, but did not produce any significant change in normal or high-sodium groups. Sodium 171-177 renin Rattus norvegicus 0-5 11446717-8 2001 CONCLUSION: The activation of renin gene expression during sodium depletion in rats is dependent on the presence of the renal nerves, while the suppression of renin gene expression during a sodium load seems to be due to the macula densa mechanism alone. Sodium 59-65 renin Rattus norvegicus 30-35 11446717-8 2001 CONCLUSION: The activation of renin gene expression during sodium depletion in rats is dependent on the presence of the renal nerves, while the suppression of renin gene expression during a sodium load seems to be due to the macula densa mechanism alone. Sodium 190-196 renin Rattus norvegicus 159-164 11411741-1 2001 Converting enzyme inhibition and angiotensin II receptor antagonism attenuate elevations in heart rate and plasma norepinephrine in response to insulin, suggesting that integrity of the renin-angiotensin system is necessary for insulin-induced sympathoexcitation. Norepinephrine 114-128 renin Rattus norvegicus 186-191 11530945-12 2001 Our results suggest that lifetime captopril treatment can decrease the activity of the renin-angiotensin system in the brain of hypertensive animals, which caused increases in basal urine flow and excretion of electrolytes and enhanced the sensitivity of baroreflex. Captopril 34-43 renin Rattus norvegicus 87-92 11411741-6 2001 These observations demonstrate an attenuation of insulin-induced sympathetic activation by renin-angiotensin blockade with captopril in Wistar rats, and suggest that the renin-angiotensin system is critical for insulin to exert its sympathoexcitatory effects. Captopril 123-132 renin Rattus norvegicus 91-96 11411741-6 2001 These observations demonstrate an attenuation of insulin-induced sympathetic activation by renin-angiotensin blockade with captopril in Wistar rats, and suggest that the renin-angiotensin system is critical for insulin to exert its sympathoexcitatory effects. Captopril 123-132 renin Rattus norvegicus 170-175 11411801-5 2001 Plasma renin activity was serially increased in SHR, which was further enhanced by amlodipine treatment. Amlodipine 83-93 renin Rattus norvegicus 7-12 11378673-6 2001 Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats. icv choline 123-134 renin Rattus norvegicus 37-42 11316844-6 2001 NS-398 did not change the increase of flow in response to bumetanide but attenuated the stimulation of renin secretion in response to bumetanide in a manner depending on the expression level of COX-2. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-6 renin Rattus norvegicus 103-108 11316844-6 2001 NS-398 did not change the increase of flow in response to bumetanide but attenuated the stimulation of renin secretion in response to bumetanide in a manner depending on the expression level of COX-2. Bumetanide 134-144 renin Rattus norvegicus 103-108 11316844-7 2001 These findings suggest that in states of increased renocortical expression of COX-2, overall renal vascular resistance and the macula densa control of renin secretion become dependent on COX-2-derived prostanoids. Prostaglandins 201-212 renin Rattus norvegicus 151-156 11171663-1 2001 The effects of blockade of the renin-angiotensin system on the renal metabolism of arachidonic acid (AA) were examined. Arachidonic Acid 83-99 renin Rattus norvegicus 31-36 11393678-7 2001 In the time course experiment, gemopatrilat (10 mg/kg) increased plasma renin activity for 8 h (P< 0.01) and inhibited plasma ACE (P< 0.05), renal NEP (P< 0.01) and renal ACE (P< 0.05) for 48 h. CONCLUSIONS: Gemopatrilat is a potent in-vitro vasopeptidase inhibitor that also causes prolonged inhibition of circulating and renal ACE and renal NEP after a single oral dose. gemopatrilat 31-43 renin Rattus norvegicus 72-77 11377534-0 2001 Effect of tacrolimus on the gene expression of renin and endothelin in the rat kidney. Tacrolimus 10-20 renin Rattus norvegicus 47-52 11290859-2 2001 We also investigated whether alcohol-induced changes in cardiac structure corresponded to activation of the renin-angiotensin system and the natriuretic peptide (NP) system. Alcohols 29-36 renin Rattus norvegicus 108-113 11273866-5 2001 Although pharmacological blockade with angiotensin II-receptor blockers and angiotensin-converting enzyme inhibitors reduces proteinuria and nephrosclerosis and/or glomerulosclerosis, selective reinfusion of aldosterone restores these abnormalities despite continued renin-angiotensin blockade. Aldosterone 208-219 renin Rattus norvegicus 267-272 11304512-2 2001 Plasma renin activity was increased in rats fed a low sodium diet and decreased in those fed a high sodium diet. Sodium 54-60 renin Rattus norvegicus 7-12 11304512-2 2001 Plasma renin activity was increased in rats fed a low sodium diet and decreased in those fed a high sodium diet. Sodium 100-106 renin Rattus norvegicus 7-12 11244027-15 2001 The degree of central but not peripheral AT(1) receptor blockade parallels the antihypertensive effect of irbesartan, indicating that inhibition of the brain renin-angiotensin system can contribute to a significant extent to the therapeutic effectiveness of AT(1) receptor blockers such as irbesartan when administered in sufficiently high doses to cause central AT(1) receptor blockade. Irbesartan 106-116 renin Rattus norvegicus 158-163 11327640-8 2001 Plasma aldosterone concentrations and plasma renin activity were decreased by high salt intake. Salts 83-87 renin Rattus norvegicus 45-50 28095242-5 2001 In contrast, RAS blockade coupled with reduced sodium diet (0.2%) significantly regresses cardiac hypertrophy, impairs animal growth and is associated with elevated plasma renin and dramatically suppressed plasma angiotensinogen levels. Sodium 47-53 renin Rattus norvegicus 172-177 11401417-5 2001 Eprosartan significantly increased plasma renin activity by four-fold and six-fold at doses of 30 and 60 mg x kg(-1), respectively (P< 0.05 vs CTRL). eprosartan 0-10 renin Rattus norvegicus 42-47 11230375-10 2001 After 6 weeks of treatment, the ALDO-salt group was found to have significantly increased blood pressure with decreased body weight and plasma renin concentration (P<0.05), LV and renal hypertrophy as well as renal injury, significantly increased collagen content in both ventricles and kidney as well as increased collagen volume fraction in the LV (P<0.0001), and significantly increased interstitial and perivascular PCNA-positive cells in the LV and kidney (P<0.0001). Aldosterone 32-36 renin Rattus norvegicus 143-148 11282148-3 2001 In the first study, we show that exposure to a basal NaCl diet (0.12%) during gestation through 4 weeks postnatally produced very large elevations in plasma renin activity (PRA) and aldosterone concentrations in the offspring. Sodium Chloride 53-57 renin Rattus norvegicus 157-162 11223191-1 2001 In Ren-2 rats, plasma active renin and prorenin increase following binephrectomy (BNx) related to increasing plasma potassium. Potassium 116-125 renin Rattus norvegicus 29-34 11223191-6 2001 Hexamethonium decreased by 50% the post BNx increase in prorenin but not active renin. Hexamethonium 0-13 renin Rattus norvegicus 59-64 11230305-10 2001 Blockade of the renin-angiotensin system by lisinopril or high salt restored the responses observed in the SS group fed a low salt diet. Lisinopril 44-54 renin Rattus norvegicus 16-21 11230375-10 2001 After 6 weeks of treatment, the ALDO-salt group was found to have significantly increased blood pressure with decreased body weight and plasma renin concentration (P<0.05), LV and renal hypertrophy as well as renal injury, significantly increased collagen content in both ventricles and kidney as well as increased collagen volume fraction in the LV (P<0.0001), and significantly increased interstitial and perivascular PCNA-positive cells in the LV and kidney (P<0.0001). Salts 37-41 renin Rattus norvegicus 143-148 11230305-10 2001 Blockade of the renin-angiotensin system by lisinopril or high salt restored the responses observed in the SS group fed a low salt diet. Salts 63-67 renin Rattus norvegicus 16-21 11230305-10 2001 Blockade of the renin-angiotensin system by lisinopril or high salt restored the responses observed in the SS group fed a low salt diet. Salts 126-130 renin Rattus norvegicus 16-21 11510275-0 2001 Renin-angiotensin system plays an important role in the regulation of water transport in the peritoneum. Water 70-75 renin Rattus norvegicus 0-5 11510275-10 2001 Our results suggest that the renin-angiotensin system plays an important role in the regulation of water transport in the peritoneum. Water 99-104 renin Rattus norvegicus 29-34 11150020-9 2001 Increased renin in the preglomerular arterioles may activate local angiotensin production, leading to intrarenal vasoconstriction, reduced nephron blood flow, sodium and water retention, and worsening of congestive heart failure. Sodium 159-165 renin Rattus norvegicus 10-15 11124154-8 2001 Phenylephrine-induced increases in arterial pressure also inhibited drinking behavior in response to hypovolemia that could not be explained by differences in plasma renin activity, plasma protein concentration, or plasma osmolality. Phenylephrine 0-13 renin Rattus norvegicus 166-171 11150020-9 2001 Increased renin in the preglomerular arterioles may activate local angiotensin production, leading to intrarenal vasoconstriction, reduced nephron blood flow, sodium and water retention, and worsening of congestive heart failure. Water 170-175 renin Rattus norvegicus 10-15 11204309-0 2001 High salt intake and the brain renin--angiotensin system in Dahl salt-sensitive rats. Salts 65-69 renin Rattus norvegicus 31-36 11116132-4 2000 The ACE inhibitor lisinopril and the angiotensin type 1 receptor antagonist losartan both increased retinal renin levels and prevented inner retinal blood vessel growth. Lisinopril 18-28 renin Rattus norvegicus 108-113 11204309-1 2001 OBJECTIVES: To assess changes in the activity of the brain renin-angiotensin system during (i) the development of salt-sensitive hypertension; and (ii) the prevention of salt-sensitive hypertension by blocking brain "ouabain". Salts 114-118 renin Rattus norvegicus 59-64 11204309-1 2001 OBJECTIVES: To assess changes in the activity of the brain renin-angiotensin system during (i) the development of salt-sensitive hypertension; and (ii) the prevention of salt-sensitive hypertension by blocking brain "ouabain". Salts 170-174 renin Rattus norvegicus 59-64 11116133-9 2000 Both S21402 and captopril increased plasma renin activity (P<0.01), all treatment lowered plasma aldosterone (P<0.05) and plasma natriuretic peptide levels were unchanged. S 21402-1 5-11 renin Rattus norvegicus 43-48 11135058-1 2001 BACKGROUND: During a low salt intake, maintenance of renal blood flow and renin secretion depends on intact formation of prostaglandins. Salts 25-29 renin Rattus norvegicus 74-79 11135058-1 2001 BACKGROUND: During a low salt intake, maintenance of renal blood flow and renin secretion depends on intact formation of prostaglandins. Prostaglandins 121-135 renin Rattus norvegicus 74-79 11135058-8 2001 Furosemide led to a fivefold and threefold increase of plasma renin activity and renocortical renin mRNA level, respectively. Furosemide 0-10 renin Rattus norvegicus 62-67 11135058-8 2001 Furosemide led to a fivefold and threefold increase of plasma renin activity and renocortical renin mRNA level, respectively. Furosemide 0-10 renin Rattus norvegicus 94-99 11135058-11 2001 Hydrochlorothiazide treatment increased plasma renin activity twofold but did not change kidney cortical renin mRNA, COX-2 mRNA, or COX-2 immunoreactivity. Hydrochlorothiazide 0-19 renin Rattus norvegicus 47-52 11135058-13 2001 This up-regulation may be of relevance for macula densa signaling, which links tubular salt transport rate with glomerular filtration rate and renin secretion. Salts 87-91 renin Rattus norvegicus 143-148 11702851-0 2001 Nitric oxide synthase mRNA levels correlate with gene expression of angiotensin II type-1 but not type-2 receptors, renin or angiotensin converting enzyme in selected brain areas. Nitric Oxide 0-12 renin Rattus norvegicus 116-154 11116133-9 2000 Both S21402 and captopril increased plasma renin activity (P<0.01), all treatment lowered plasma aldosterone (P<0.05) and plasma natriuretic peptide levels were unchanged. Captopril 16-25 renin Rattus norvegicus 43-48 11116132-4 2000 The ACE inhibitor lisinopril and the angiotensin type 1 receptor antagonist losartan both increased retinal renin levels and prevented inner retinal blood vessel growth. Losartan 76-84 renin Rattus norvegicus 108-113 11078373-3 2000 In the study reported here, we investigated the more chronic effects of hypoxia (10% O2 for 4 weeks) on renin gene expression and the influence of the ET system on its regulation. Oxygen 85-87 renin Rattus norvegicus 104-109 11115066-7 2000 In proximal tubules, mRNA for renin was significantly increased in STZ rats, with reversal to control values in STZ-I rats (C, 2432 +/- 437 vs. STZ, 5688 +/- 890 fg/0.25 microg RNA, P < 0.05 vs. C, N = 9, vs. STZ-I, 1676 +/- 376 fg/0.25 microg RNA, P = NS vs. C). Streptozocin 67-70 renin Rattus norvegicus 30-35 11115066-7 2000 In proximal tubules, mRNA for renin was significantly increased in STZ rats, with reversal to control values in STZ-I rats (C, 2432 +/- 437 vs. STZ, 5688 +/- 890 fg/0.25 microg RNA, P < 0.05 vs. C, N = 9, vs. STZ-I, 1676 +/- 376 fg/0.25 microg RNA, P = NS vs. C). Streptozocin 112-115 renin Rattus norvegicus 30-35 11115066-7 2000 In proximal tubules, mRNA for renin was significantly increased in STZ rats, with reversal to control values in STZ-I rats (C, 2432 +/- 437 vs. STZ, 5688 +/- 890 fg/0.25 microg RNA, P < 0.05 vs. C, N = 9, vs. STZ-I, 1676 +/- 376 fg/0.25 microg RNA, P = NS vs. C). Streptozocin 112-115 renin Rattus norvegicus 30-35 11115066-7 2000 In proximal tubules, mRNA for renin was significantly increased in STZ rats, with reversal to control values in STZ-I rats (C, 2432 +/- 437 vs. STZ, 5688 +/- 890 fg/0.25 microg RNA, P < 0.05 vs. C, N = 9, vs. STZ-I, 1676 +/- 376 fg/0.25 microg RNA, P = NS vs. C). Streptozocin 112-115 renin Rattus norvegicus 30-35 11115066-8 2000 In STZ rats, the AT1 receptor antagonist losartan caused a further fivefold increase in proximal tubule renin mRNA, associated with proximal tubular renin immunostaining. Losartan 41-49 renin Rattus norvegicus 104-109 11115066-8 2000 In STZ rats, the AT1 receptor antagonist losartan caused a further fivefold increase in proximal tubule renin mRNA, associated with proximal tubular renin immunostaining. Losartan 41-49 renin Rattus norvegicus 149-154 11115066-11 2000 CONCLUSIONS: These data suggest activation of the proximal tubule renin-angiotensin system in early STZ diabetes, mediated at least partly by enhanced expression of renin mRNA. Streptozocin 100-103 renin Rattus norvegicus 66-71 11115066-11 2000 CONCLUSIONS: These data suggest activation of the proximal tubule renin-angiotensin system in early STZ diabetes, mediated at least partly by enhanced expression of renin mRNA. Streptozocin 100-103 renin Rattus norvegicus 165-170 11211108-6 2000 L-NAME but not rofecoxib attenuated renin mRNA levels. NG-Nitroarginine Methyl Ester 0-6 renin Rattus norvegicus 36-41 11053474-1 2000 Chronic inhibition of the renin angiotensin system prevents increased BP and renal injury in N(G)-nitro-L-arginine methyl ester (L-NAME) hypertension. NG-Nitroarginine Methyl Ester 93-127 renin Rattus norvegicus 26-31 11053474-1 2000 Chronic inhibition of the renin angiotensin system prevents increased BP and renal injury in N(G)-nitro-L-arginine methyl ester (L-NAME) hypertension. NG-Nitroarginine Methyl Ester 129-135 renin Rattus norvegicus 26-31 11053474-10 2000 Plasma renin activity was suppressed in the DOCA (0.55 +/- 0.2) and L-NAME + DOCA (0.60 +/- 10.2) groups but unsuppressed in the L-NAME + DOCA + losartan group (5.8 +/- 1). Desoxycorticosterone Acetate 44-48 renin Rattus norvegicus 7-12 11053474-10 2000 Plasma renin activity was suppressed in the DOCA (0.55 +/- 0.2) and L-NAME + DOCA (0.60 +/- 10.2) groups but unsuppressed in the L-NAME + DOCA + losartan group (5.8 +/- 1). NG-Nitroarginine Methyl Ester 68-74 renin Rattus norvegicus 7-12 11053474-10 2000 Plasma renin activity was suppressed in the DOCA (0.55 +/- 0.2) and L-NAME + DOCA (0.60 +/- 10.2) groups but unsuppressed in the L-NAME + DOCA + losartan group (5.8 +/- 1). Desoxycorticosterone Acetate 77-81 renin Rattus norvegicus 7-12 11053474-10 2000 Plasma renin activity was suppressed in the DOCA (0.55 +/- 0.2) and L-NAME + DOCA (0.60 +/- 10.2) groups but unsuppressed in the L-NAME + DOCA + losartan group (5.8 +/- 1). Desoxycorticosterone Acetate 77-81 renin Rattus norvegicus 7-12 11053474-10 2000 Plasma renin activity was suppressed in the DOCA (0.55 +/- 0.2) and L-NAME + DOCA (0.60 +/- 10.2) groups but unsuppressed in the L-NAME + DOCA + losartan group (5.8 +/- 1). Losartan 145-153 renin Rattus norvegicus 7-12 11078373-5 2000 Concomitant administration of the ET(A)-receptor antagonist LU135252 led to a significant increase in renin gene expression compared to control or hypoxia alone. darusentan 60-68 renin Rattus norvegicus 102-107 11787472-1 2000 Gastric sodium loading results in an increase in the portal venous concentration of vasoactive intestinal peptide (VIP) and down-regulation of both the intrahepatic and circulating renin-angiotensin systems. Sodium 8-14 renin Rattus norvegicus 181-186 10956274-2 2000 By administering DOCA and renin, we generated a need-free sodium appetite quickly enough to permit us to monitor the activity of individual neurons in the nucleus of the solitary tract before and after its creation, permitting a more powerful within-subjects design. Sodium 58-64 renin Rattus norvegicus 26-31 10956274-5 2000 In neural recordings, renin caused decreased responding to hypertonic NaCl across all neurons and in the salt-sensitive neurons that were most responsive to NaCl before infusion. Sodium Chloride 70-74 renin Rattus norvegicus 22-27 10956274-5 2000 In neural recordings, renin caused decreased responding to hypertonic NaCl across all neurons and in the salt-sensitive neurons that were most responsive to NaCl before infusion. Salts 105-109 renin Rattus norvegicus 22-27 10956274-5 2000 In neural recordings, renin caused decreased responding to hypertonic NaCl across all neurons and in the salt-sensitive neurons that were most responsive to NaCl before infusion. Sodium Chloride 157-161 renin Rattus norvegicus 22-27 11071817-3 2000 This involved measuring the effect of centrally administered antisense ODNs on water drinking that occurred in response to intracerebroventricular injection of hog renin. Water 79-84 renin Rattus norvegicus 164-169 11041166-2 2000 In normotensive rats, a single dose of oral omapatrilat (10 mg/kg) and 1 mg/kg inhibited plasma ACE (P < .01) for 24 h and increased plasma renin activity for 8 h (P < .01). omapatrilat 44-55 renin Rattus norvegicus 143-148 11041166-6 2000 Omapatrilat caused significant inhibition of plasma ACE and increased plasma renin activity (both doses, P < .01), and in vitro autoradiographic studies indicated sustained inhibition of renal ACE and NEP (both doses, P < .01). omapatrilat 0-11 renin Rattus norvegicus 77-82 11026649-9 2000 Furthermore, high-dose indapamide increased plasma renin activity substantially, whereas low-dose treatment was without effect on circulating renin. Indapamide 23-33 renin Rattus norvegicus 51-56 11026649-10 2000 In conclusion, in rats with continuous LV pressure-overload low-dose treatment with indapamide leads to mild regression of cardiac hypertrophy, accompanied by a downregulation of components of the cardiac renin-angiotensin system. Indapamide 84-94 renin Rattus norvegicus 205-210 11041555-3 2000 Whilst all four K+ channel blockers increased renal vascular resistance, only 4-aminopyridine and barium attenuated isoproterenol-stimulated renin secretion in an additive fashion and augmented the inhibitory effect of angiotensin II. 4-Aminopyridine 78-93 renin Rattus norvegicus 141-146 11041555-3 2000 Whilst all four K+ channel blockers increased renal vascular resistance, only 4-aminopyridine and barium attenuated isoproterenol-stimulated renin secretion in an additive fashion and augmented the inhibitory effect of angiotensin II. Barium 98-104 renin Rattus norvegicus 141-146 11041555-3 2000 Whilst all four K+ channel blockers increased renal vascular resistance, only 4-aminopyridine and barium attenuated isoproterenol-stimulated renin secretion in an additive fashion and augmented the inhibitory effect of angiotensin II. Isoproterenol 116-129 renin Rattus norvegicus 141-146 11014370-8 2000 L-NAME increased plasma renin activity and left ventricular weight/body weight ratio, whereas plasma endothelin-1 was not modified. NG-Nitroarginine Methyl Ester 0-6 renin Rattus norvegicus 24-29 11787472-10 2000 These changes are similar to those reported after gastric sodium loading, and we suggest, therefore, that the increase in portal venous VIP that occurs after gastric sodium is the means by which the gastric sodium sensor signals the liver to effect these changes in the renin-angiotensin system. Sodium 58-64 renin Rattus norvegicus 270-275 11787472-10 2000 These changes are similar to those reported after gastric sodium loading, and we suggest, therefore, that the increase in portal venous VIP that occurs after gastric sodium is the means by which the gastric sodium sensor signals the liver to effect these changes in the renin-angiotensin system. Sodium 166-172 renin Rattus norvegicus 270-275 11787472-10 2000 These changes are similar to those reported after gastric sodium loading, and we suggest, therefore, that the increase in portal venous VIP that occurs after gastric sodium is the means by which the gastric sodium sensor signals the liver to effect these changes in the renin-angiotensin system. Sodium 166-172 renin Rattus norvegicus 270-275 10989749-3 2000 The beta-adrenoceptors stimulation by isoprenaline was used to increase the plasma renin activity (PRA). Isoproterenol 38-50 renin Rattus norvegicus 83-88 10994763-2 2000 In the present studies, we assessed whether the cardiac hypertrophy induced by high salt depends on the development of hypertension per se, and leads to over-activity of the cardiac renin-angiotensin system (RAS). Salts 84-88 renin Rattus norvegicus 182-187 10938248-1 2000 Injection of rats either with diazoxide (25 mg/kg iv), isoproterenol (0.33 mg/kg sc), or hydralazine (HDZ) (10 mg/kg ip) decreased arterial blood pressure from approximately 120 to 70-80 mmHg and stimulated renin secretion. Hydralazine 89-100 renin Rattus norvegicus 207-212 10938248-1 2000 Injection of rats either with diazoxide (25 mg/kg iv), isoproterenol (0.33 mg/kg sc), or hydralazine (HDZ) (10 mg/kg ip) decreased arterial blood pressure from approximately 120 to 70-80 mmHg and stimulated renin secretion. Hydralazine 102-105 renin Rattus norvegicus 207-212 10988275-5 2000 Exposure to the low-salt diet increased plasma renin activity and elevated plasma levels of angiotensin I and angiotensin II in SHR by 81% and 68%, respectively, above values determined in SHR fed a normal salt diet. Salts 20-24 renin Rattus norvegicus 47-52 10938248-1 2000 Injection of rats either with diazoxide (25 mg/kg iv), isoproterenol (0.33 mg/kg sc), or hydralazine (HDZ) (10 mg/kg ip) decreased arterial blood pressure from approximately 120 to 70-80 mmHg and stimulated renin secretion. Diazoxide 30-39 renin Rattus norvegicus 207-212 10938248-1 2000 Injection of rats either with diazoxide (25 mg/kg iv), isoproterenol (0.33 mg/kg sc), or hydralazine (HDZ) (10 mg/kg ip) decreased arterial blood pressure from approximately 120 to 70-80 mmHg and stimulated renin secretion. Isoproterenol 55-68 renin Rattus norvegicus 207-212 10894799-0 2000 Store-operated calcium influx inhibits renin secretion. Calcium 15-22 renin Rattus norvegicus 39-44 10954003-4 2000 RESULTS: A low sodium diet (0.02% NaCl) for 14 days elevated plasma-renin activity (PRA) nine-fold, from 6.1 +/- 2.0 to 54.9 +/- 6.5 ng angiotensin I (Ang I)/ml per h (P < 0.0001). Sodium Chloride 34-38 renin Rattus norvegicus 68-73 10954002-6 2000 The high sodium diet induced a greater fall in the plasma renin activity in the SBH/y (-95%) than in the SBN/y (-63%). Sodium 9-15 renin Rattus norvegicus 58-63 10954003-0 2000 Chronic cyclooxygenase-2 inhibition blunts low sodium-stimulated renin without changing renal haemodynamics. Sodium 47-53 renin Rattus norvegicus 65-70 10954003-4 2000 RESULTS: A low sodium diet (0.02% NaCl) for 14 days elevated plasma-renin activity (PRA) nine-fold, from 6.1 +/- 2.0 to 54.9 +/- 6.5 ng angiotensin I (Ang I)/ml per h (P < 0.0001). Sodium 15-21 renin Rattus norvegicus 68-73 10894799-1 2000 On the basis of evidence that changes in the extracellular concentration of calcium effectively modulate renin secretion from renal juxtaglomerular cells, our study aimed to determine the effect of calcium influx activated by depletion of intracellular calcium stores on renin secretion. Calcium 76-83 renin Rattus norvegicus 105-110 10894799-1 2000 On the basis of evidence that changes in the extracellular concentration of calcium effectively modulate renin secretion from renal juxtaglomerular cells, our study aimed to determine the effect of calcium influx activated by depletion of intracellular calcium stores on renin secretion. Calcium 198-205 renin Rattus norvegicus 271-276 10894799-1 2000 On the basis of evidence that changes in the extracellular concentration of calcium effectively modulate renin secretion from renal juxtaglomerular cells, our study aimed to determine the effect of calcium influx activated by depletion of intracellular calcium stores on renin secretion. Calcium 198-205 renin Rattus norvegicus 271-276 10894799-2 2000 For this purpose we characterized the effects of the endoplasmatic Ca(2+)-ATPase inhibitors thapsigargin (300 nM) and cyclopiazonic acid (20 microM) on renin secretion from isolated perfused rat kidneys. Thapsigargin 92-104 renin Rattus norvegicus 152-157 10894799-2 2000 For this purpose we characterized the effects of the endoplasmatic Ca(2+)-ATPase inhibitors thapsigargin (300 nM) and cyclopiazonic acid (20 microM) on renin secretion from isolated perfused rat kidneys. cyclopiazonic acid 118-136 renin Rattus norvegicus 152-157 10894799-3 2000 We found that Ca(2+)-ATPase inhibition caused a potent inhibition of basal renin secretion as well as renin secretion activated by isoproterenol, bumetanide, and by a fall in the renal perfusion pressure. Isoproterenol 131-144 renin Rattus norvegicus 102-107 10894799-3 2000 We found that Ca(2+)-ATPase inhibition caused a potent inhibition of basal renin secretion as well as renin secretion activated by isoproterenol, bumetanide, and by a fall in the renal perfusion pressure. Bumetanide 146-156 renin Rattus norvegicus 102-107 10894799-4 2000 The inhibitory effect of Ca(2+)-ATPase inhibition on renin secretion was reversed within seconds by lowering of the extracellular calcium concentration into the submicromolar range but was not affected by lanthanum, gadolinium, flufenamic acid, or amlodipine. Calcium 130-137 renin Rattus norvegicus 53-58 10894799-4 2000 The inhibitory effect of Ca(2+)-ATPase inhibition on renin secretion was reversed within seconds by lowering of the extracellular calcium concentration into the submicromolar range but was not affected by lanthanum, gadolinium, flufenamic acid, or amlodipine. Amlodipine 248-258 renin Rattus norvegicus 53-58 10894799-5 2000 These data suggest that calcium influx triggered by release of calcium from internal stores is a powerful mechanism to inhibit renin secretion from juxtaglomerular cells. Calcium 24-31 renin Rattus norvegicus 127-132 10894799-5 2000 These data suggest that calcium influx triggered by release of calcium from internal stores is a powerful mechanism to inhibit renin secretion from juxtaglomerular cells. Calcium 63-70 renin Rattus norvegicus 127-132 10892668-0 2000 Evidence that prostaglandins mediate the antihypertensive actions of angiotensin-(1-7) during chronic blockade of the renin-angiotensin system. Prostaglandins 14-28 renin Rattus norvegicus 118-123 10919359-13 2000 Thus, SA7060 may be useful for treatment of both renin-dependent and renin-independent hypertensive subjects, although further studies examining efficiency in a renin-dependent hypertensive model are needed. SA 7060 6-12 renin Rattus norvegicus 49-74 10919359-13 2000 Thus, SA7060 may be useful for treatment of both renin-dependent and renin-independent hypertensive subjects, although further studies examining efficiency in a renin-dependent hypertensive model are needed. SA 7060 6-12 renin Rattus norvegicus 49-54 10872553-0 2000 The tissue renin-angiotensin system in rats with fructose-induced hypertension: overexpression of type 1 angiotensin II receptor in adipose tissue. Fructose 49-57 renin Rattus norvegicus 11-16 10803761-14 2000 In conclusion, this study indicates that caffeine adversely affects renal function in PAN-nephrotic rats, and that this effect may be due, in part, to increased activity of the renin angiotensin system. Caffeine 41-49 renin Rattus norvegicus 177-182 10872560-7 2000 Captopril and S21402 increased plasma renin activity (P< 0.05), but the rise with S21402 was attenuated compared with that caused by captopril (P< 0.01). Captopril 0-9 renin Rattus norvegicus 38-43 10872560-10 2000 The dual NEP/ACE inhibitor S21402 offered no advantage over the selective ACE inhibitor in terms of blood pressure reduction, or attenuation of cardiac hypertrophy and fibrosis, but did increase plasma ANP and blunted the reactive rise in renin with ACE inhibition. S 21402-1 27-33 renin Rattus norvegicus 239-244 10803602-8 2000 Plasma aldosterone concentrations and plasma renin concentrations were decreased by high sodium intake. Sodium 89-95 renin Rattus norvegicus 45-50 10792607-11 2000 The beneficial effects afforded by valsartan therapy strengthen the importance of the local renin-angiotensin system in mediating progressive diabetic renal injury. Valsartan 35-44 renin Rattus norvegicus 92-97 10792624-10 2000 Renin-angiotensin II blockade by oral captopril administration did not influence the alteration in rBSC1 mRNA induced by myocardial infarction. Captopril 38-47 renin Rattus norvegicus 0-5 10771297-3 2000 Secretion of renin was induced using beta-adrenoceptor stimulation produced by isoprenaline. Isoproterenol 79-91 renin Rattus norvegicus 13-18 10771297-11 2000 Isoprenaline increased plasma renin activity and did not modify plasma catecholamine concentrations. Isoproterenol 0-12 renin Rattus norvegicus 30-35 11210717-2 2000 Six weeks after experiment initiation, plasma renin activity of DOCA-treated rats was reduced to approximately 12% that of sham-treated and AC-treated groups. Desoxycorticosterone Acetate 64-68 renin Rattus norvegicus 46-51 11210717-2 2000 Six weeks after experiment initiation, plasma renin activity of DOCA-treated rats was reduced to approximately 12% that of sham-treated and AC-treated groups. Actinium 140-142 renin Rattus norvegicus 46-51 11210717-6 2000 These data suggest that circulating renin is required for the anti-hypertrophic efficacy of late-onset brief treatment with enalapril. Enalapril 124-133 renin Rattus norvegicus 36-41 10657023-8 2000 Similarly, the DOI-induced elevation of plasma renin was markedly potentiated in male (+51%) and female (+83%) cocaine-exposed offspring. Cocaine 111-118 renin Rattus norvegicus 47-52 10872553-4 2000 DESIGN AND METHODS: To investigate the role of the renin-angiotensin system in fructose-induced hypertension we measured angiotensinogen, renin and angiotensin II type 1 (AT1) receptor mRNA levels in tissues of Sprague-Dawley rats that were fed either standard rat chow or a diet containing 66% fructose. Fructose 79-87 renin Rattus norvegicus 51-56 10758056-5 2000 Furthermore, the role of ROS in vascular function and hypertension in low-renin hypertension is undefined. Reactive Oxygen Species 25-28 renin Rattus norvegicus 74-79 10758056-12 2000 CONCLUSIONS: These findings indicate that increased vascular superoxide production occurs not only in angiotensin II-induced hypertension but also in hypertension known to be associated with low-renin states. Superoxides 61-71 renin Rattus norvegicus 195-200 10712275-4 2000 Ventricular hypertrophy was initiated within 7 days and maintained for 35 days in DOCA-treated rats despite significantly low myocardial and plasma renin, normal or low myocardial and plasma angiotensinogen, or the presence of losartan. Desoxycorticosterone Acetate 82-86 renin Rattus norvegicus 148-153 10803761-10 2000 Seven days after both PAN injections, increased plasma renin activity was detected in animals that were consuming caffeine as compared with corresponding control groups (CAFF and CAFF + PAN vs CON and PAN, respectively). Caffeine 114-122 renin Rattus norvegicus 55-60 10803761-10 2000 Seven days after both PAN injections, increased plasma renin activity was detected in animals that were consuming caffeine as compared with corresponding control groups (CAFF and CAFF + PAN vs CON and PAN, respectively). caff 170-174 renin Rattus norvegicus 55-60 10803761-10 2000 Seven days after both PAN injections, increased plasma renin activity was detected in animals that were consuming caffeine as compared with corresponding control groups (CAFF and CAFF + PAN vs CON and PAN, respectively). caff 179-183 renin Rattus norvegicus 55-60 10644643-2 2000 We now report that OT infused intravenously into conscious rats at 125 ng x kg(-1) x h(-1), a dose selected to mimic plasma OT levels during hypotension or hypovolemia, increased plasma renin concentration and plasma renin activity by twofold. Oxytocin 19-21 renin Rattus norvegicus 186-191 10679504-6 2000 L-NNA produced sustained hypertension, decreased glomerular filtration rate, and increased renal vascular resistance, plasma renin activity, and urinary albumin excretion. Nitroarginine 0-5 renin Rattus norvegicus 125-130 10731931-9 2000 As expected, rats fed a sodium deficient diet were associated with increased immunoreactivity for Na-K-ATPase and renin compatible with activation of the renin-angiotensin system. Sodium 24-30 renin Rattus norvegicus 114-119 10731931-9 2000 As expected, rats fed a sodium deficient diet were associated with increased immunoreactivity for Na-K-ATPase and renin compatible with activation of the renin-angiotensin system. Sodium 24-30 renin Rattus norvegicus 154-159 10691807-9 2000 These results show that at least a portion of the natriuretic effect of dopamine can be attributed to inhibition of AVP-dependent Na+ reabsorption by the CCD, and they introduce another signalling system as a candidate in the aetiology of low-renin, salt-dependent hypertension. Dopamine 72-80 renin Rattus norvegicus 243-248 10644643-2 2000 We now report that OT infused intravenously into conscious rats at 125 ng x kg(-1) x h(-1), a dose selected to mimic plasma OT levels during hypotension or hypovolemia, increased plasma renin concentration and plasma renin activity by twofold. Oxytocin 19-21 renin Rattus norvegicus 217-222 10644643-5 2000 Pretreatment of rats with the beta-adrenergic receptor antagonist nadolol also prevented OT-induced renin secretion. Nadolol 66-73 renin Rattus norvegicus 100-105 10644643-6 2000 Similarly, nadolol injected during infusion of OT markedly reduced the elevated plasma renin levels. Nadolol 11-18 renin Rattus norvegicus 87-92 10600659-0 2000 Modulation of the intrahepatic renin-angiotensin system after stimulation of the gastric sodium monitor in the rat. Sodium 89-95 renin Rattus norvegicus 31-36 10642301-13 2000 The inhibition of the renin-angiotensin system is probably a second mechanism to produce the sustained antihypertensive effect of beta(1)-AS-ODN. beta(1)-as-odn 130-144 renin Rattus norvegicus 22-27 10523375-11 1999 Plasma renin activity was reduced at day 21 (L-NNA=9.6+/-2.1 and C=25.9+/-5 ng x mL(-1) x h(-1), P<0.05) and remained lower at postpartum day 7 x L-NNA rats exhibited glomerular lesions and tubular atrophy, particularly of connecting tubules that displayed reduced kallikrein staining. Nitroarginine 45-50 renin Rattus norvegicus 7-12 10642339-10 2000 Together, these findings suggest that brain FMRFamide-activated sodium channels may be involved in the mechanism of salt-sensitive hypertension through regulation of the brain renin-angiotensin system. Salts 116-120 renin Rattus norvegicus 176-181 10604960-7 2000 The high dose of furosemide (100 mg/kg) significantly elevated serum renin activity and aldosterone concentration, indicating that furosemide activated the renin-angiotensin-aldosterone system (RAA-system). Furosemide 17-27 renin Rattus norvegicus 69-74 10604960-7 2000 The high dose of furosemide (100 mg/kg) significantly elevated serum renin activity and aldosterone concentration, indicating that furosemide activated the renin-angiotensin-aldosterone system (RAA-system). Furosemide 17-27 renin Rattus norvegicus 156-161 10604960-7 2000 The high dose of furosemide (100 mg/kg) significantly elevated serum renin activity and aldosterone concentration, indicating that furosemide activated the renin-angiotensin-aldosterone system (RAA-system). Furosemide 131-141 renin Rattus norvegicus 69-74 10604960-7 2000 The high dose of furosemide (100 mg/kg) significantly elevated serum renin activity and aldosterone concentration, indicating that furosemide activated the renin-angiotensin-aldosterone system (RAA-system). Furosemide 131-141 renin Rattus norvegicus 156-161 10561814-11 1999 These results suggest that NO has an inhibitory role on renin release in DS rats fed a high-salt diet. Salts 92-96 renin Rattus norvegicus 56-61 10516122-0 1999 Potassium control of extrarenal renin secretion in transgenic (mRen-2)27 and normal rats. Potassium 0-9 renin Rattus norvegicus 32-37 10516122-2 1999 In Ren-2 rats, active renin and prorenin increased with plasma potassium post-BNx and were augmented by potassium infusion. Potassium 63-72 renin Rattus norvegicus 22-27 10516122-2 1999 In Ren-2 rats, active renin and prorenin increased with plasma potassium post-BNx and were augmented by potassium infusion. Potassium 104-113 renin Rattus norvegicus 22-27 10516122-8 1999 The unidentified source of active renin in BNx+BADRx Ren-2 rats is also potassium and stress related. Potassium 72-81 renin Rattus norvegicus 34-39 10516123-3 1999 Secretion of active renin from these sites correlated significantly with increasing plasma potassium. Potassium 91-100 renin Rattus norvegicus 20-25 10523345-17 1999 h(-1) in the untreated-DOCA group) renin concentrations. Desoxycorticosterone Acetate 23-27 renin Rattus norvegicus 35-40 10690283-1 1999 OBJECTIVES: To elucidate the relationship between renin-angiotensin system and nitric oxide in hypertensive heart failure, we evaluated the effects of long-term treatment with imidapril, angiotensin-converting enzyme inhibitor, on endothelial-cell nitric oxide synthase (eNOS) and inducible NOS (iNOS) expression in the left ventricle (LV) and its relation to myocardial remodelling in failing heart of Dahl salt-sensitive hypertensive rats (DS) fed a high-salt diet. Nitric Oxide 79-91 renin Rattus norvegicus 50-55 10561814-0 1999 Inhibitory effect of nitric oxide on the renin-angiotensin system in Dahl salt-sensitive rats. Nitric Oxide 21-33 renin Rattus norvegicus 41-46 10561814-0 1999 Inhibitory effect of nitric oxide on the renin-angiotensin system in Dahl salt-sensitive rats. dahl salt 69-78 renin Rattus norvegicus 41-46 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Chloralose 49-59 renin Rattus norvegicus 172-177 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Urethane 60-68 renin Rattus norvegicus 121-126 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Urethane 60-68 renin Rattus norvegicus 172-177 10517817-7 1999 Chloralose-urethane anaesthesia and surgery caused a rise in plasma renin activity but was associated with a suppression of renal renin (50 %, P < 0.01) and angiotensinogen (40 %, P < 0.05) gene expression. Chloralose 0-10 renin Rattus norvegicus 68-73 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Urethane 60-68 renin Rattus norvegicus 172-177 10517817-7 1999 Chloralose-urethane anaesthesia and surgery caused a rise in plasma renin activity but was associated with a suppression of renal renin (50 %, P < 0.01) and angiotensinogen (40 %, P < 0.05) gene expression. Chloralose 0-10 renin Rattus norvegicus 130-135 10517817-7 1999 Chloralose-urethane anaesthesia and surgery caused a rise in plasma renin activity but was associated with a suppression of renal renin (50 %, P < 0.01) and angiotensinogen (40 %, P < 0.05) gene expression. Urethane 11-19 renin Rattus norvegicus 68-73 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Urethane 60-68 renin Rattus norvegicus 172-177 10517817-7 1999 Chloralose-urethane anaesthesia and surgery caused a rise in plasma renin activity but was associated with a suppression of renal renin (50 %, P < 0.01) and angiotensinogen (40 %, P < 0.05) gene expression. Urethane 11-19 renin Rattus norvegicus 130-135 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Urethane 60-68 renin Rattus norvegicus 172-177 10517817-10 1999 Chronic (5 days) blockade of angiotensin II receptors with losartan elevated plasma renin activity some 29-fold (P < 0.001) and caused a marked increase (30-fold, P < 0.05) in renal renin gene expression, compatible with angiotensin II exerting a negative feedback control on renin release and gene expression. Losartan 59-67 renin Rattus norvegicus 84-89 10535331-8 1999 Given the pronounced decrease in blood pressure and impaired survival following subarachnoid haemorrhage in animals treated with losartan, it would appear that the acute activation of the renin-angiotensin system following this insult is in fact a desirable, compensatory response. Losartan 129-137 renin Rattus norvegicus 188-193 10517817-10 1999 Chronic (5 days) blockade of angiotensin II receptors with losartan elevated plasma renin activity some 29-fold (P < 0.001) and caused a marked increase (30-fold, P < 0.05) in renal renin gene expression, compatible with angiotensin II exerting a negative feedback control on renin release and gene expression. Losartan 59-67 renin Rattus norvegicus 188-193 10517817-10 1999 Chronic (5 days) blockade of angiotensin II receptors with losartan elevated plasma renin activity some 29-fold (P < 0.001) and caused a marked increase (30-fold, P < 0.05) in renal renin gene expression, compatible with angiotensin II exerting a negative feedback control on renin release and gene expression. Losartan 59-67 renin Rattus norvegicus 188-193 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Chloralose 49-59 renin Rattus norvegicus 121-126 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Chloralose 49-59 renin Rattus norvegicus 172-177 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Chloralose 49-59 renin Rattus norvegicus 172-177 10517817-13 1999 From these findings it can be concluded that (a) chloralose-urethane anaesthesia and surgery had a stimulatory effect on renin release but suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of RPP for 3 h could stimulate renin gene expression in the renin producing cells; and (c) the negative feedback control of angiotensin II on renin release and synthesis which was evident following chronic losartan treatment was not apparent during short-term reduction of RPP. Chloralose 49-59 renin Rattus norvegicus 172-177 10555568-3 1999 Renin secretion prestimulated by isoproterenol (10 nmol/l) was almost completely blocked by ANGII with a concentration yielding a half-maximal response (EC50) of around 150 nmol/l. Isoproterenol 33-46 renin Rattus norvegicus 0-5 10555568-6 1999 On the assumption that the chloride equilibrium potential in renin-secreting cells is more positive than the membrane potential, our findings would suggest that the inhibitory effect of ANGII is enhanced when chloride entry is blocked and attenuated when chloride efflux is impaired. Chlorides 27-35 renin Rattus norvegicus 61-66 10555568-6 1999 On the assumption that the chloride equilibrium potential in renin-secreting cells is more positive than the membrane potential, our findings would suggest that the inhibitory effect of ANGII is enhanced when chloride entry is blocked and attenuated when chloride efflux is impaired. Chlorides 209-217 renin Rattus norvegicus 61-66 10555568-6 1999 On the assumption that the chloride equilibrium potential in renin-secreting cells is more positive than the membrane potential, our findings would suggest that the inhibitory effect of ANGII is enhanced when chloride entry is blocked and attenuated when chloride efflux is impaired. Chlorides 209-217 renin Rattus norvegicus 61-66 10528129-10 1999 In WKY rats, SB 209670 decreased Ren blood flow whilst increasing Mes and HQ blood flows and Cond. Antimony 13-15 renin Rattus norvegicus 33-36 10528129-14 1999 In WKY rats, the hypotensive effect of SB 209670 was accompanied by Mes and HQ vasodilatation, but with Ren vasoconstriction. Antimony 39-41 renin Rattus norvegicus 104-107 10406830-2 1999 We have previously shown that in renal cortex, cyclooxygenase-2 (COX-2) expression is localized to the macula densa and surrounding cortical thick ascending limb and increases in high-renin states, such as salt restriction and angiotensin-converting enzyme inhibition. Salts 206-210 renin Rattus norvegicus 184-189 10433936-7 1999 In perindopril-treated STNx rats expression of renin and TGF-beta1 were similar to control animals. Perindopril 3-14 renin Rattus norvegicus 47-52 10432392-9 1999 Consistent with this, we found that PGE2-evoked cAMP production and renin secretion by JG cells from salt-deprived animals were significantly higher compared with cells obtained from salt-loaded animals. Salts 101-105 renin Rattus norvegicus 68-73 10432392-12 1999 The results are in accord with the general concept that renocortical PGE2 stimulates renin secretion and maintains renal blood flow during low-salt states, whereas medullary PGE2 promotes salt excretion in response to a high salt intake. Dinoprostone 69-73 renin Rattus norvegicus 85-90 10417395-8 1999 Although losartan, a specific AT(1) antagonist, completely inhibited Ang II-induced upregulation of angiotensinogen, renin, and ACE genes, as well as stretch-induced upregulation of AT(1A) expression, it did not block upregulation of angiotensinogen, renin, and ACE genes by stretch. Losartan 9-17 renin Rattus norvegicus 117-122 10417395-8 1999 Although losartan, a specific AT(1) antagonist, completely inhibited Ang II-induced upregulation of angiotensinogen, renin, and ACE genes, as well as stretch-induced upregulation of AT(1A) expression, it did not block upregulation of angiotensinogen, renin, and ACE genes by stretch. Losartan 9-17 renin Rattus norvegicus 251-256 10451540-2 1999 In this study, changes in the renin-angiotensin-aldosterone (RAA) system level was determined in Streptozotocin (STZ)-injected rats. Streptozocin 97-111 renin Rattus norvegicus 30-35 10451540-2 1999 In this study, changes in the renin-angiotensin-aldosterone (RAA) system level was determined in Streptozotocin (STZ)-injected rats. Streptozocin 113-116 renin Rattus norvegicus 30-35 10489401-10 1999 Because macula densa-derived prostaglandins are considered stimulators of renin secretion and renin synthesis, inhibition of macula densa COX-2 by angiotensin II could form a novel indirect negative feedback control of the renin system. Prostaglandins 29-43 renin Rattus norvegicus 74-79 10489401-10 1999 Because macula densa-derived prostaglandins are considered stimulators of renin secretion and renin synthesis, inhibition of macula densa COX-2 by angiotensin II could form a novel indirect negative feedback control of the renin system. Prostaglandins 29-43 renin Rattus norvegicus 94-99 10489401-10 1999 Because macula densa-derived prostaglandins are considered stimulators of renin secretion and renin synthesis, inhibition of macula densa COX-2 by angiotensin II could form a novel indirect negative feedback control of the renin system. Prostaglandins 29-43 renin Rattus norvegicus 94-99 10446934-12 1999 Human and rat renin and angiotensinogen genes were downregulated in dTGR and were increased by losartan and cilazapril treatments, whereas no changes in the expression of rat ACE and AT1A receptor genes were observed. Losartan 95-103 renin Rattus norvegicus 14-19 10446934-12 1999 Human and rat renin and angiotensinogen genes were downregulated in dTGR and were increased by losartan and cilazapril treatments, whereas no changes in the expression of rat ACE and AT1A receptor genes were observed. Cilazapril 108-118 renin Rattus norvegicus 14-19 10406830-3 1999 In the present studies, we examined the effect of the selective COX-2 inhibitor SC58236 on plasma renin activity (PRA) and renal renin expression in RVH in rats. 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 80-87 renin Rattus norvegicus 98-103 10406830-16 1999 In summary, these studies indicate that the selective COX-2 inhibitor SC58236 decreases renin production and release in RVH and suggest an important role for COX-2 regulation of the renin-angiotensin system. 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 70-77 renin Rattus norvegicus 88-93 10406830-16 1999 In summary, these studies indicate that the selective COX-2 inhibitor SC58236 decreases renin production and release in RVH and suggest an important role for COX-2 regulation of the renin-angiotensin system. 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 70-77 renin Rattus norvegicus 182-187 10406832-1 1999 In Dahl salt-sensitive rats on a high salt diet or normotensive rats with chronic central infusion of sodium, increased brain "ouabain" results in sympathetic hyperactivity and hypertension, possibly by activating the brain renin-angiotensin system. Sodium 102-108 renin Rattus norvegicus 224-229 10406832-11 1999 These results indicate that chronic administration of ouabain activates the brain renin-angiotensin system, resulting in decreased sympathoinhibition and increased sympathoexcitation, impairment of baroreflex function, and hypertension. Ouabain 54-61 renin Rattus norvegicus 82-87 10750586-4 1999 FCM rapidly activated signal transduction events in cardiac myocytes associated with hypertrophic stimuli, including: (1) increased tyrosine phosphorylation of several prominent protein bands; (2) mitogen-activated protein kinases (ERK 1 and ERK 2); and (3) protein kinase C. Finally, FCM caused an increase at 8 hours in angiotensinogen mRNA levels of cardiac myocytes, whereas no effect was observed on mRNA levels for renin or the type 1 angiotensin II receptor (AT1). Fosfomycin 0-3 renin Rattus norvegicus 421-426 10419065-1 1999 OBJECTIVE: We recently reported that the renin-angiotensin system plays an important role in the progression of vascular and kidney injuries, even in Dahl salt-sensitive rats with volume-dependent hypertension. Salts 155-159 renin Rattus norvegicus 41-46 10419066-10 1999 Plasma renin activity was decreased 71% (P< 0.001) in guanethidine-treated rats compared with vehicle. Guanethidine 57-69 renin Rattus norvegicus 7-12 10419066-15 1999 CONCLUSIONS: Impairment of the sympathetic nervous system with guanethidine withdraws the normal stimulation of this system on the circulating renin-angiotensin system, but upregulates the expression of adrenal Ang II receptors. Guanethidine 63-75 renin Rattus norvegicus 143-148 10358118-3 1999 Here we report the effects of levcromakalim (LCRK, a channel opener) and glibenclamide (GBC, a blocker) on membrane potential, whole-cell current and the cytoplasmic Ca2+ concentration of renin-secreting cells (RSC). Cromakalim 30-43 renin Rattus norvegicus 188-193 10358118-3 1999 Here we report the effects of levcromakalim (LCRK, a channel opener) and glibenclamide (GBC, a blocker) on membrane potential, whole-cell current and the cytoplasmic Ca2+ concentration of renin-secreting cells (RSC). Glyburide 73-86 renin Rattus norvegicus 188-193 10233035-1 1999 Changes in the renin-angiotensin system (RAS) mRNAs in the brain and the kidney of rats after administration of DOCA and/or sodium chloride were assessed by use of a competitive PCR method. Desoxycorticosterone Acetate 112-116 renin Rattus norvegicus 15-20 10336514-7 1999 The renin-angiotensin system was evaluated by measurements of ACE activity in plasma samples, using the synthetic substrate Hip-His-Leu, by determinations of plasma renin concentrations and measurements of arterial blood pressure. hip-his 124-131 renin Rattus norvegicus 4-9 10336514-7 1999 The renin-angiotensin system was evaluated by measurements of ACE activity in plasma samples, using the synthetic substrate Hip-His-Leu, by determinations of plasma renin concentrations and measurements of arterial blood pressure. Leucine 132-135 renin Rattus norvegicus 4-9 10233035-1 1999 Changes in the renin-angiotensin system (RAS) mRNAs in the brain and the kidney of rats after administration of DOCA and/or sodium chloride were assessed by use of a competitive PCR method. Sodium Chloride 124-139 renin Rattus norvegicus 15-20 10233035-4 1999 Intracerebroventricular infusion of benzamil decreased renin, ACE, and ANG II type 1 receptor mRNAs in the brain of DOCA-salt hypertensive rats but not in the brain of renal hypertensive rats. benzamil 36-44 renin Rattus norvegicus 55-60 10233035-5 1999 The gene expression of the brain RAS, particularly renin and ACE, is regulated differently between the brain and the kidney in DOCA-salt hypertensive rats, and benzamil-blockable brain sodium channels may participate in the regulation of the brain RAS mRNAs. Desoxycorticosterone Acetate 127-131 renin Rattus norvegicus 51-56 10233035-5 1999 The gene expression of the brain RAS, particularly renin and ACE, is regulated differently between the brain and the kidney in DOCA-salt hypertensive rats, and benzamil-blockable brain sodium channels may participate in the regulation of the brain RAS mRNAs. Salts 132-136 renin Rattus norvegicus 51-56 10233039-6 1999 Plasma levels of aldosterone and plasma renin activity are substantially increased 3 h after furosemide treatment, and so the NaCl appetite cannot result simply from progressively increasing levels of these hormones. Furosemide 93-103 renin Rattus norvegicus 40-45 10392657-5 1999 It can first be demonstrated 72 h postnatally when an intracerebroventricular injection of renin elicits greater swallowing of NaCl solution than water and greater mouthing of solid fragments of NaCl than of an artificial sweetener. nacl solution 127-140 renin Rattus norvegicus 91-96 10392657-5 1999 It can first be demonstrated 72 h postnatally when an intracerebroventricular injection of renin elicits greater swallowing of NaCl solution than water and greater mouthing of solid fragments of NaCl than of an artificial sweetener. Water 146-151 renin Rattus norvegicus 91-96 10392657-5 1999 It can first be demonstrated 72 h postnatally when an intracerebroventricular injection of renin elicits greater swallowing of NaCl solution than water and greater mouthing of solid fragments of NaCl than of an artificial sweetener. Sodium Chloride 127-131 renin Rattus norvegicus 91-96 10218729-7 1999 In RHDs, oral administration of FR172516 once daily for 5 days decreased blood pressure without reflex tachycardia or an increase of plasma renin activity. FR 172516 32-40 renin Rattus norvegicus 140-145 10981063-1 1999 Nitric oxide (NO) plays critical roles in the control of renal and glomerular hemodynamics, tubuloglomerular feedback response, release of renin and sympathetic transmitters, tubular ion transport, and renal water and sodium excretion. Nitric Oxide 0-12 renin Rattus norvegicus 139-144 10357430-3 1999 This study examined whether the elevated ingestion of saline by Long-Evans rats after BDL is associated with increased plasma renin activity (PRA), and whether treatment with a low dose of the angiotensin converting-enzyme inhibitor CAP further exacerbates fluid intake and PRA after BDL. Sodium Chloride 54-60 renin Rattus norvegicus 126-131 10205230-5 1999 In clipped rats with saline administration, plasma renin activity, the ratio of left ventricular weight to body weight, and mRNAs for beta-myosin heavy chain and atrial natriuretic peptide were significantly elevated as early as 2 days after surgery. Sodium Chloride 21-27 renin Rattus norvegicus 51-56 10194467-6 1999 Plasma renin activity increased significantly in the captropril group, and this increase was significantly inhibited by simultaneous treatment with SC58236. captropril 53-63 renin Rattus norvegicus 7-12 10194467-6 1999 Plasma renin activity increased significantly in the captropril group, and this increase was significantly inhibited by simultaneous treatment with SC58236. 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 148-155 renin Rattus norvegicus 7-12 10218729-8 1999 On the other hand, amlodipine, in the dose at which hypotensive effects equipotent to those of FR172516 were observed, produced apparent reflex tachycardia and concomitant increase of plasma renin. Amlodipine 19-29 renin Rattus norvegicus 191-196 10069669-1 1999 Our previous studies supported the hypothesis that prolonged administration of caffeine to animals with high-renin hypertension causes progressive deterioration of renal function. Caffeine 79-87 renin Rattus norvegicus 109-114 10340121-3 1999 The cardioprotective effect was attended with a normalizing influence on the renin-angiotensin system parameters which were significantly changed after experimental damage to the myocardium: perindopril restored angiotensin I clearance and the level of angiotensin II production in the lungs. Perindopril 191-202 renin Rattus norvegicus 77-82 10069681-0 1999 Caffeine increases renal renin secretion in a rat model of genetic heart failure. Caffeine 0-8 renin Rattus norvegicus 25-30 10069669-12 1999 These data support our hypothesis that prolonged consumption of caffeine has adverse effects on renal function, in high-renin hypertension. Caffeine 64-72 renin Rattus norvegicus 120-125 10069681-1 1999 In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leading to increased central sympathetic tone. Caffeine 36-44 renin Rattus norvegicus 68-73 10069681-1 1999 In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leading to increased central sympathetic tone. Caffeine 36-44 renin Rattus norvegicus 181-186 11501132-1 1999 OBJECTIVE: To observe changes in cardiac renin-angiotensin and its effect on sarcoplasmic reticulum(SR) calcium transport function, and investigate the mechanism underlying cardiac dysfunction in early postburn stage. Calcium 104-111 renin Rattus norvegicus 41-46 10069681-1 1999 In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leading to increased central sympathetic tone. Caffeine 46-50 renin Rattus norvegicus 68-73 10069681-7 1999 CAFF increased plasma renin activity (PRA), norepinephrine (NE), and epinephrine (E) levels in all three strains [treatment effect, p<0.001, 2F analysis of variance (ANOVA)], and these effects were greater in hypertensive (SHRs and SHHF) animals as compared with normotensive WKY rats (p<0.015). Caffeine 0-4 renin Rattus norvegicus 22-27 10069681-9 1999 However, CAFF treatment significantly increased renal renin secretion (71.1+/-19.2 vs. 9.5+/-5.8 ng Ang I/h/min/kg for caffeine and control group, respectively; p<0.01). Caffeine 9-13 renin Rattus norvegicus 54-59 10069681-12 1999 Moreover, this study provides the first evidence that short-term caffeine consumption increases renal renin secretion in heart failure, an effect most likely due to the blockade of intrarenal adenosine receptors. Caffeine 65-73 renin Rattus norvegicus 102-107 11501132-11 1999 CONCLUSION: The cardiac renin-angiotensin system is activated rapidly after severe burns and inhibits the calcium transport function which may play an important role in cardiac contractile dysfunction following burns. Calcium 106-113 renin Rattus norvegicus 24-29 9927293-0 1999 Losartan and angiotensin II inhibit aldosterone production in anephric rats via different actions on the intraadrenal renin-angiotensin system. Losartan 0-8 renin Rattus norvegicus 118-123 10069682-7 1999 Renal renin gene expression was increased 8.6-fold by irbesartan and 17.7-fold by captopril. Irbesartan 54-64 renin Rattus norvegicus 6-11 10069682-7 1999 Renal renin gene expression was increased 8.6-fold by irbesartan and 17.7-fold by captopril. Captopril 82-91 renin Rattus norvegicus 6-11 9927293-7 1999 Because the effects of losartan or ANG II on aldosterone production involved a latency period of at least 30 h after NX and were associated with a modulation or recruitment of renin-producing cells, we suggest that the intraadrenal renin-angiotensin system operates via regulation of cell differentiation on a long-term scale, rather than or additionally to its short-term effects on aldosterone synthase activity. Losartan 23-31 renin Rattus norvegicus 176-181 9927293-7 1999 Because the effects of losartan or ANG II on aldosterone production involved a latency period of at least 30 h after NX and were associated with a modulation or recruitment of renin-producing cells, we suggest that the intraadrenal renin-angiotensin system operates via regulation of cell differentiation on a long-term scale, rather than or additionally to its short-term effects on aldosterone synthase activity. Losartan 23-31 renin Rattus norvegicus 232-237 12973413-4 1999 Candesartan cilexetil produces the expected changes in the parameters of the renin-angiotensin system. candesartan 0-11 renin Rattus norvegicus 77-82 12973413-4 1999 Candesartan cilexetil produces the expected changes in the parameters of the renin-angiotensin system. Cyclohexyl propan-2-yl carbonate 12-21 renin Rattus norvegicus 77-82 9892165-7 1999 Plasma renin concentration was reduced by L-NAME from 122+/-23 to 69+/-14 ng AngI/ml per h and not further modified by L-arginine (71+/-16 ng AngI/ml per h). NG-Nitroarginine Methyl Ester 42-48 renin Rattus norvegicus 7-12 9914402-1 1999 The cytosolic concentration of chloride correlates directly with renin secretion from renal juxtaglomerular granular (JG) cells. Chlorides 31-39 renin Rattus norvegicus 65-70 9914402-2 1999 In the present study, the mechanism by which chloride stimulates renin release was investigated in a preparation of permeabilized rat glomeruli with attached JG cells. Chlorides 45-53 renin Rattus norvegicus 65-70 9914402-3 1999 An isosmotic increase in the concentration of chloride by 129 mM stimulated renin release 16- to 20-fold. Chlorides 46-54 renin Rattus norvegicus 76-81 9914402-6 1999 Addition of sucrose, which permeates the secretory granules poorly, also abolished the stimulation of renin secretion by KCl. Sucrose 12-19 renin Rattus norvegicus 102-107 9914402-6 1999 Addition of sucrose, which permeates the secretory granules poorly, also abolished the stimulation of renin secretion by KCl. Potassium Chloride 121-124 renin Rattus norvegicus 102-107 9914402-9 1999 When the ATP concentration was lowered from 1 to 0.1 mM renin release was stimulated, while an increase in the ATP concentration from 1 to 5 mM had no effect. Adenosine Triphosphate 9-12 renin Rattus norvegicus 56-61 9914402-11 1999 The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results in swelling and release of renin. Chlorides 30-38 renin Rattus norvegicus 50-55 9914402-11 1999 The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results in swelling and release of renin. Chlorides 30-38 renin Rattus norvegicus 92-97 9914402-11 1999 The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results in swelling and release of renin. Chlorides 30-38 renin Rattus norvegicus 92-97 9895038-1 1999 Demonstrations that alcohol intake can be inhibited by pharmacological activation of the renal renin-angiotensin system (RRA) or injection of angiotensin II (ANG II) in rats led to this study of a role for endogenous ANG II in inhibition of alcohol intake in rats. Alcohols 20-27 renin Rattus norvegicus 95-100 9895038-3 1999 The 0.312 and 1.25 mg/kg doses of SC histamine elevated plasma renin activity to levels similar to those in rats that had just eaten food. Histamine 37-46 renin Rattus norvegicus 63-68 9914402-11 1999 The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results in swelling and release of renin. Potassium Chloride 79-82 renin Rattus norvegicus 50-55 9914402-11 1999 The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results in swelling and release of renin. Potassium Chloride 79-82 renin Rattus norvegicus 92-97 9914402-11 1999 The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results in swelling and release of renin. Potassium Chloride 79-82 renin Rattus norvegicus 92-97 9988128-4 1999 The MAP kinase activation was inhibited either by the renin inhibitor pepstatin A or by the angiotensin-converting enzyme inhibitor captopril. pepstatin 70-81 renin Rattus norvegicus 54-59 9988128-6 1999 Pepstatin A inhibited MAP kinase activation induced by renin but not by angiotensin I and angiotensin II. pepstatin 0-11 renin Rattus norvegicus 55-60 9892155-0 1999 Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system. Desoxycorticosterone Acetate 32-59 renin Rattus norvegicus 104-109 9892155-0 1999 Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system. Salts 60-64 renin Rattus norvegicus 104-109 9892155-2 1999 This project has determined the expression and deposition of collagens and fibronectin and cardiac function in the deoxycorticosterone acetate (DOCA)-salt hypertensive rat after inhibition of the renin-angiotensin system. Desoxycorticosterone Acetate 115-142 renin Rattus norvegicus 196-201 9892155-2 1999 This project has determined the expression and deposition of collagens and fibronectin and cardiac function in the deoxycorticosterone acetate (DOCA)-salt hypertensive rat after inhibition of the renin-angiotensin system. Desoxycorticosterone Acetate 144-148 renin Rattus norvegicus 196-201 9892155-2 1999 This project has determined the expression and deposition of collagens and fibronectin and cardiac function in the deoxycorticosterone acetate (DOCA)-salt hypertensive rat after inhibition of the renin-angiotensin system. Salts 150-154 renin Rattus norvegicus 196-201 9892155-12 1999 Thus, inhibition of the renin-angiotensin system reverses cardiac fibrosis in DOCA-salt rats and returns some indices of myocardial function to normal. Desoxycorticosterone Acetate 78-82 renin Rattus norvegicus 24-29 9892155-12 1999 Thus, inhibition of the renin-angiotensin system reverses cardiac fibrosis in DOCA-salt rats and returns some indices of myocardial function to normal. Salts 83-87 renin Rattus norvegicus 24-29 9892158-0 1999 Effects of candesartan on the renin system in conscious rats. candesartan 11-22 renin Rattus norvegicus 30-35 9892158-1 1999 This study aimed to assess and to compare the effects of cadesartan cilexetil on the renin system in rats. cadesartan cilexetil 57-77 renin Rattus norvegicus 85-90 9884422-1 1999 To elucidate whether sulfonylureas directly influence renin secretion, the effect of tolbutamide, glibenclamide, or chlorpropamide on renin secretion was investigated by using the perfused kidney of the rat. Chlorpropamide 116-130 renin Rattus norvegicus 134-139 9884422-3 1999 Renin activity significantly increased from a basal value of 11.7 +/- 3.6 to a peak value of 20.6 +/- 5.5 ng/Ang I/ml/h with tolbutamide, from 14.4 +/- 4.6 to 32.7 +/- 6.5 ng/Ang I/ml/h with glibenclamide, and from 15.0 +/- 4.9 to 30.4 +/- 6.1 ng/Ang I/ml/h with chlorpropamide. Tolbutamide 125-136 renin Rattus norvegicus 0-5 9884422-0 1999 Sulfonylureas stimulate renin secretion from the perfused kidney of the rat. Sulfonylurea Compounds 0-13 renin Rattus norvegicus 24-29 9884422-3 1999 Renin activity significantly increased from a basal value of 11.7 +/- 3.6 to a peak value of 20.6 +/- 5.5 ng/Ang I/ml/h with tolbutamide, from 14.4 +/- 4.6 to 32.7 +/- 6.5 ng/Ang I/ml/h with glibenclamide, and from 15.0 +/- 4.9 to 30.4 +/- 6.1 ng/Ang I/ml/h with chlorpropamide. Glyburide 191-204 renin Rattus norvegicus 0-5 9884422-3 1999 Renin activity significantly increased from a basal value of 11.7 +/- 3.6 to a peak value of 20.6 +/- 5.5 ng/Ang I/ml/h with tolbutamide, from 14.4 +/- 4.6 to 32.7 +/- 6.5 ng/Ang I/ml/h with glibenclamide, and from 15.0 +/- 4.9 to 30.4 +/- 6.1 ng/Ang I/ml/h with chlorpropamide. Chlorpropamide 263-277 renin Rattus norvegicus 0-5 9884422-5 1999 In kidneys perfused with a calcium-free medium, glibenclamide produced a significant increase in renin activity from a basal value of 13.4 +/- 2.1 to a peak value of 30.6 +/- 3.4 ng Ang I/ml/h. Glyburide 48-61 renin Rattus norvegicus 97-102 9884422-6 1999 These results suggest that sulfonylureas stimulate renin secretion from perfused rat kidneys. Sulfonylurea Compounds 27-40 renin Rattus norvegicus 51-56 9877518-6 1998 The plasma renin activity was significantly higher in rats treated with L-NAME than in the control rats. NG-Nitroarginine Methyl Ester 72-78 renin Rattus norvegicus 11-16 9817604-5 1998 We used electrophoretic mobility shift assays to determine if these mutations alter the pattern or affinity of nuclear protein binding to oligonucleotides homologous to these regions of the renin gene. Oligonucleotides 138-154 renin Rattus norvegicus 190-195 9817604-6 1998 Both mutations significantly altered the intensity and pattern of nuclear protein binding to oligonucleotides homologous with the renin gene regions bearing these putative transcription factor binding sites. Oligonucleotides 93-109 renin Rattus norvegicus 130-135 9844137-10 1998 CONCLUSIONS: Failure to suppress proximal tubular renin in response to high dietary NaCl may result in increased local generation of angiotensin II and enhanced proximal tubular NaCl absorption, and thereby contribute to the generation of salt sensitive hypertension. Salts 239-243 renin Rattus norvegicus 50-55 9648823-4 1998 Glucose infusion rates (GIRs) were lower in the REN and IH groups than in the other groups. Glucose 0-7 renin Rattus norvegicus 48-51 9844137-2 1998 Abnormalities in renal hemodynamics and NaCl handling have been implicated, and may relate to changes in the activity of the intrarenal renin-angiotensin system. Sodium Chloride 40-44 renin Rattus norvegicus 136-141 9844137-6 1998 RESULTS: Circulating and juxtaglomerular renin were suppressed by high dietary NaCl in salt-sensitive rats (plasma renin activity, 0.5%, 10.9 +/- 0.7 vs. 4%, 7.9 +/- 0.3 ng/ml/hr, P < 0.05; renin secretory rate, 0.5% 220 +/- 32 vs. 4%, 58 +/- 5 ng/mg/hr, P < 0.05). Sodium Chloride 79-83 renin Rattus norvegicus 41-46 9844137-6 1998 RESULTS: Circulating and juxtaglomerular renin were suppressed by high dietary NaCl in salt-sensitive rats (plasma renin activity, 0.5%, 10.9 +/- 0.7 vs. 4%, 7.9 +/- 0.3 ng/ml/hr, P < 0.05; renin secretory rate, 0.5% 220 +/- 32 vs. 4%, 58 +/- 5 ng/mg/hr, P < 0.05). Sodium Chloride 79-83 renin Rattus norvegicus 115-120 9844137-6 1998 RESULTS: Circulating and juxtaglomerular renin were suppressed by high dietary NaCl in salt-sensitive rats (plasma renin activity, 0.5%, 10.9 +/- 0.7 vs. 4%, 7.9 +/- 0.3 ng/ml/hr, P < 0.05; renin secretory rate, 0.5% 220 +/- 32 vs. 4%, 58 +/- 5 ng/mg/hr, P < 0.05). Sodium Chloride 79-83 renin Rattus norvegicus 115-120 9844137-6 1998 RESULTS: Circulating and juxtaglomerular renin were suppressed by high dietary NaCl in salt-sensitive rats (plasma renin activity, 0.5%, 10.9 +/- 0.7 vs. 4%, 7.9 +/- 0.3 ng/ml/hr, P < 0.05; renin secretory rate, 0.5% 220 +/- 32 vs. 4%, 58 +/- 5 ng/mg/hr, P < 0.05). Salts 87-91 renin Rattus norvegicus 41-46 9844137-6 1998 RESULTS: Circulating and juxtaglomerular renin were suppressed by high dietary NaCl in salt-sensitive rats (plasma renin activity, 0.5%, 10.9 +/- 0.7 vs. 4%, 7.9 +/- 0.3 ng/ml/hr, P < 0.05; renin secretory rate, 0.5% 220 +/- 32 vs. 4%, 58 +/- 5 ng/mg/hr, P < 0.05). Salts 87-91 renin Rattus norvegicus 115-120 9844137-6 1998 RESULTS: Circulating and juxtaglomerular renin were suppressed by high dietary NaCl in salt-sensitive rats (plasma renin activity, 0.5%, 10.9 +/- 0.7 vs. 4%, 7.9 +/- 0.3 ng/ml/hr, P < 0.05; renin secretory rate, 0.5% 220 +/- 32 vs. 4%, 58 +/- 5 ng/mg/hr, P < 0.05). Salts 87-91 renin Rattus norvegicus 115-120 9844137-7 1998 Glomerular renin mRNA was also suppressed by the higher salt diet in salt-sensitive animals (0.5%, 411 +/- 84 vs. 4%, 67 +/- 22 x 103 copies/glomerulus, P < 0.05). Salts 56-60 renin Rattus norvegicus 11-16 9844137-7 1998 Glomerular renin mRNA was also suppressed by the higher salt diet in salt-sensitive animals (0.5%, 411 +/- 84 vs. 4%, 67 +/- 22 x 103 copies/glomerulus, P < 0.05). Salts 69-73 renin Rattus norvegicus 11-16 9844137-10 1998 CONCLUSIONS: Failure to suppress proximal tubular renin in response to high dietary NaCl may result in increased local generation of angiotensin II and enhanced proximal tubular NaCl absorption, and thereby contribute to the generation of salt sensitive hypertension. Sodium Chloride 84-88 renin Rattus norvegicus 50-55 9844137-10 1998 CONCLUSIONS: Failure to suppress proximal tubular renin in response to high dietary NaCl may result in increased local generation of angiotensin II and enhanced proximal tubular NaCl absorption, and thereby contribute to the generation of salt sensitive hypertension. Sodium Chloride 178-182 renin Rattus norvegicus 50-55 9788971-2 1998 Renal renin mRNA levels both under stimulatory (low-salt diet plus ramipril) and inhibitory (high-salt diet) conditions were not different between wild-type and cGKI-/- mice, but were significantly elevated in cGKII-/- mice under all experimental conditions. Ramipril 67-75 renin Rattus norvegicus 6-11 9736275-5 1998 Because norepinephrine increased 1.7-fold and 3.2-fold and plasma epinephrine increased 3.9-fold and 7.8-fold during hypoxia and CO inhalation, respectively, circulating catecholamines might mediate the stimulatory effects of hypoxia on renin secretion and renin gene expression. Catecholamines 170-184 renin Rattus norvegicus 237-242 9736275-5 1998 Because norepinephrine increased 1.7-fold and 3.2-fold and plasma epinephrine increased 3.9-fold and 7.8-fold during hypoxia and CO inhalation, respectively, circulating catecholamines might mediate the stimulatory effects of hypoxia on renin secretion and renin gene expression. Catecholamines 170-184 renin Rattus norvegicus 257-262 9690200-11 1998 Perindopril attenuated renal pathology, improved renal function and abolished proximal tubular renin immunolabeling in diabetic TGR. Perindopril 0-11 renin Rattus norvegicus 95-100 9750011-12 1998 In contrast, potassium diet appears to be a determinant for the concomitant responses in plasma renin activity and renal sodium and potassium excretion. Potassium 13-22 renin Rattus norvegicus 96-101 9788971-3 1998 In primary cultures of renal juxtaglomerular cells (JG) established from wild-type, cGKI-/-, and cGKII-/- mice, the adenylate cyclase activator forskolin stimulated renin secretion similarly in all genotypes tested. Colforsin 144-153 renin Rattus norvegicus 165-170 9788971-4 1998 8-bromo-cGMP attenuated basal and forskolin-stimulated renin secretion in cultures from wild-type and cGKI-/-, but had no effect in cells isolated from cGKII-/- mice. 8-bromocyclic GMP 0-12 renin Rattus norvegicus 55-60 9788971-4 1998 8-bromo-cGMP attenuated basal and forskolin-stimulated renin secretion in cultures from wild-type and cGKI-/-, but had no effect in cells isolated from cGKII-/- mice. Colforsin 34-43 renin Rattus norvegicus 55-60 9788971-5 1998 Activation of cGKs by 8-bromo-cGMP decreased renin secretion from the isolated perfused rat kidney, independent of prestimulation by beta-adrenoreceptor activation, macula densa inhibition, reduced perfusion pressure, or by a nominally calcium-free perfusate. 8-bromocyclic GMP 22-34 renin Rattus norvegicus 45-50 9657629-6 1998 The plasma renin activity was significantly higher in rats treated with L-NAME than in the control rats. NG-Nitroarginine Methyl Ester 72-78 renin Rattus norvegicus 11-16 9655867-10 1998 Although 8-OH-DPAT did not increase plasma levels of renin or vasopressin in rats treated with vehicle, 8-OH-DPAT produced an elevation (75%) in plasma renin concentration but not in vasopressin levels in rats that received i.c.v. 8-Hydroxy-2-(di-n-propylamino)tetralin 104-113 renin Rattus norvegicus 152-157 9647484-6 1998 Amlodipine dose-dependently induced up to 7 fold elevation of PRA and renin mRNA levels. Amlodipine 0-10 renin Rattus norvegicus 70-75 9647484-7 1998 Mibefradil significantly lowered PRA and renin mRNA levels at 5 mg kg(-1) and moderately increased both parameters at a dose of 45 mg kg(-1), when PRA and renin mRNA levels were increased by 100% and 30%, respectively. Mibefradil 0-10 renin Rattus norvegicus 41-46 9647484-7 1998 Mibefradil significantly lowered PRA and renin mRNA levels at 5 mg kg(-1) and moderately increased both parameters at a dose of 45 mg kg(-1), when PRA and renin mRNA levels were increased by 100% and 30%, respectively. Mibefradil 0-10 renin Rattus norvegicus 155-160 9647484-11 1998 In contrast mibefradil (5 mg kg(-1) and 15 mg kg(-1) day(-1)) significantly attenuated the rise of PRA and renin mRNA levels, whilst amlodipine (15 mg kg(-1)) additionally elevated the rise of PRA and renin mRNA levels in response to renal artery clipping. Mibefradil 12-22 renin Rattus norvegicus 107-112 9647484-11 1998 In contrast mibefradil (5 mg kg(-1) and 15 mg kg(-1) day(-1)) significantly attenuated the rise of PRA and renin mRNA levels, whilst amlodipine (15 mg kg(-1)) additionally elevated the rise of PRA and renin mRNA levels in response to renal artery clipping. Mibefradil 12-22 renin Rattus norvegicus 201-206 9612349-10 1998 With lisinopril, renal renin concentration increased at both pH values. Lisinopril 5-15 renin Rattus norvegicus 23-28 9694563-3 1998 Using in situ hybridisation methods, it was demonstrated that transcription of the (pro)renin gene is regulated by sodium status, and is increased specifically in the zona glomerulosa by a low sodium diet. Sodium 115-121 renin Rattus norvegicus 88-93 9694563-3 1998 Using in situ hybridisation methods, it was demonstrated that transcription of the (pro)renin gene is regulated by sodium status, and is increased specifically in the zona glomerulosa by a low sodium diet. Sodium 193-199 renin Rattus norvegicus 88-93 9618396-2 1998 Furthermore, Ca++-induced inhibition of renin secretion in depolarizing K+-rich Krebs-Ringer bicarbonate not only was prevented completely but also reversed by ML-7 in a concentration-dependent and reversible manner. krebs 80-85 renin Rattus norvegicus 40-45 9618396-2 1998 Furthermore, Ca++-induced inhibition of renin secretion in depolarizing K+-rich Krebs-Ringer bicarbonate not only was prevented completely but also reversed by ML-7 in a concentration-dependent and reversible manner. Bicarbonates 93-104 renin Rattus norvegicus 40-45 9618396-2 1998 Furthermore, Ca++-induced inhibition of renin secretion in depolarizing K+-rich Krebs-Ringer bicarbonate not only was prevented completely but also reversed by ML-7 in a concentration-dependent and reversible manner. ML 7 160-164 renin Rattus norvegicus 40-45 9618396-3 1998 On the other hand, calyculin A (3 x 10(-)6 M) blocked both effects of ML-7 on stimulation and reversal of renin secretion independently of intracellular Ca++ concentrations. calyculin A 19-30 renin Rattus norvegicus 106-111 9576107-9 1998 Amlodipine decreased SBP, increased plasma renin concentration, and was without effect on IEL rupture. Amlodipine 0-10 renin Rattus norvegicus 43-48 9612349-12 1998 Ribonuclease protection assay showed both rat and mouse renin gene expression in the kidney, which increased with lisinopril. Lisinopril 114-124 renin Rattus norvegicus 56-61 9593069-0 1998 Effects of the angiotensin II type-1 receptor antagonist ZD7155 on angiotensin II-mediated regulation of renin secretion and renal renin gene expression, renal vasoconstriction, and blood pressure in rats. ZD 7155 57-63 renin Rattus norvegicus 105-110 9593069-4 1998 In isolated perfused rat kidneys, ZD7155 completely abolished the angiotensin II-induced vasoconstriction and increased renin secretion to 700% of baseline levels. ZD 7155 34-40 renin Rattus norvegicus 120-125 9593069-6 1998 Our results suggest that ZD7155 is a potent antagonist of the angiotensin II type-1 receptor, which mediates angiotensin II-induced increases of free intracellular calcium concentrations in (e.g., renal mesangial cells), constriction of the renal and systemic vasculature, and inhibition of renin secretion and synthesis. ZD 7155 25-31 renin Rattus norvegicus 291-296 9641614-2 1998 The neuronal mechanisms are not fully understood but may involve the neurotransmitter histamine (HA) since centrally infused HA stimulates renin secretion. Histamine 86-95 renin Rattus norvegicus 139-144 9797176-6 1998 RESULTS: After oral administration of ZD7155, blood pressure was rapidly lowered and this lowering was sustained for up to 48 h. This effect was accompanied by sustained inhibition of angiotensin II receptor binding in the aorta, kidney and adrenal gland, together with an increase in plasma renin activity. ZD 7155 38-44 renin Rattus norvegicus 292-297 9641614-2 1998 The neuronal mechanisms are not fully understood but may involve the neurotransmitter histamine (HA) since centrally infused HA stimulates renin secretion. Histamine 97-99 renin Rattus norvegicus 139-144 9652368-1 1998 Previous studies suggest that the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) increases the secretion of oxytocin, adrenocorticotropic hormone (ACTH), corticosterone and prolactin but not renin. 8-Hydroxy-2-(di-n-propylamino)tetralin 58-97 renin Rattus norvegicus 220-225 9652368-1 1998 Previous studies suggest that the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) increases the secretion of oxytocin, adrenocorticotropic hormone (ACTH), corticosterone and prolactin but not renin. 8-Hydroxy-2-(di-n-propylamino)tetralin 99-108 renin Rattus norvegicus 220-225 9652368-4 1998 8-OH-DPAT, 500 microg/kg s.c., increased plasma levels of oxytocin (to 970% above basal levels); ACTH (to 1622% above basal levels), corticosterone (to 458% above basal levels) and prolactin (to 313% above basal levels), but not renin. 8-Hydroxy-2-(di-n-propylamino)tetralin 0-9 renin Rattus norvegicus 229-234 9652368-8 1998 At the highest dose of WAY-100635 (10 mg/kg, s.c.), basal prolactin levels were markedly elevated (1550%) and administration of 8-OH-DPAT significantly elevated plasma renin concentration. N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide 23-33 renin Rattus norvegicus 168-173 9652368-8 1998 At the highest dose of WAY-100635 (10 mg/kg, s.c.), basal prolactin levels were markedly elevated (1550%) and administration of 8-OH-DPAT significantly elevated plasma renin concentration. 8-Hydroxy-2-(di-n-propylamino)tetralin 128-137 renin Rattus norvegicus 168-173 9652368-9 1998 Taken together, these data indicate that: (1) 8-OH-DPAT stimulates oxytocin, ACTH, and corticosterone but not prolactin secretion via activation of 5-HT1A receptors and (2) blockade of 5-HT1A receptors may unmask 8-OH-DPAT simulation of renin secretion via non-5-HT1A receptor mechanisms. 8-Hydroxy-2-(di-n-propylamino)tetralin 46-55 renin Rattus norvegicus 237-242 9605497-0 1998 Central administration of a nitric oxide synthase inhibitor causes pressor responses via the sympathetic nervous system and the renin-angiotensin system in Wistar rats. Nitric Oxide 28-40 renin Rattus norvegicus 128-133 9605497-9 1998 These results suggest that the response of the blood pressure to L-NAME is mediated by both the sympathetic nervous system and the renin-angiotensin system. NG-Nitroarginine Methyl Ester 65-71 renin Rattus norvegicus 131-136 10374392-13 1998 Renin activity increased and angiotensin II concentration decreased significantly in both plasma and renal tissue in diabetes + perindopril groups (P < 0.05). Perindopril 128-139 renin Rattus norvegicus 0-5 9683914-8 1998 In order to differentiate the potential role of elevated renin in the down-regulation of pulmonary ACE, additional rats (n = 12) were treated with furosemide that resulted in a 8-fold rise in plasma renin activity, but only in a marginal decrease of pulmonary ACE mRNA levels and activity (-10% vs. sham (n = 8), P-value n.s.). Furosemide 147-157 renin Rattus norvegicus 199-204 9479020-9 1998 Finally, the dependence on calcium of the cromakalim-induced stimulation of renin was examined. Cromakalim 42-52 renin Rattus norvegicus 76-81 9479020-10 1998 Addition of the calcium antagonist amlodipine to the perfusate stimulated renin secretion, and in this situation cromakalim had no further effect. Calcium 16-23 renin Rattus norvegicus 74-79 9479020-1 1998 This study aimed to investigate the functional role of ATP-sensitive K+ (KATP) channels in the control of renin secretion by renal perfusion pressure. Adenosine Triphosphate 55-58 renin Rattus norvegicus 106-111 9479020-10 1998 Addition of the calcium antagonist amlodipine to the perfusate stimulated renin secretion, and in this situation cromakalim had no further effect. Amlodipine 35-45 renin Rattus norvegicus 74-79 9461242-5 1998 At the end of the treatment period, enalapril and losartan exerted dose-dependent and, when combined, additive effects in terms of blood pressure fall and cardiac hypertrophy limitation, and synergistic effects in terms of plasma active renin stimulation and blockade of exogenous angiotensin I pressor effects, with E3L3>E3>L3, E1L1>E1> or =L1, and E1L1=E3>L3). Enalapril 36-45 renin Rattus norvegicus 237-242 9544878-0 1998 Effects of omapatrilat in low, normal, and high renin experimental hypertension. omapatrilat 11-22 renin Rattus norvegicus 48-53 9544878-7 1998 The results indicate that omapatrilat is a potent dual metalloprotease inhibitor of NEP and ACE with long lasting, oral antihypertensive effects in low, normal, and high renin models of hypertension. omapatrilat 26-37 renin Rattus norvegicus 170-175 9486151-2 1998 Despite a lack of immediate effect, incubation with triiodothyronine dose dependently increased renin secretion during the first 6 h and elevated renin content and renin mRNA levels during the subsequent period. Triiodothyronine 52-68 renin Rattus norvegicus 96-101 9486151-2 1998 Despite a lack of immediate effect, incubation with triiodothyronine dose dependently increased renin secretion during the first 6 h and elevated renin content and renin mRNA levels during the subsequent period. Triiodothyronine 52-68 renin Rattus norvegicus 146-151 9486151-2 1998 Despite a lack of immediate effect, incubation with triiodothyronine dose dependently increased renin secretion during the first 6 h and elevated renin content and renin mRNA levels during the subsequent period. Triiodothyronine 52-68 renin Rattus norvegicus 146-151 9486151-3 1998 Simultaneous incubation with triiodothyronine and the calcium ionophore A-23187 abolished the increase in renin secretion and attenuated the increase in renin content but did not affect the increase in renin mRNA levels. Triiodothyronine 29-45 renin Rattus norvegicus 106-111 9486151-3 1998 Simultaneous incubation with triiodothyronine and the calcium ionophore A-23187 abolished the increase in renin secretion and attenuated the increase in renin content but did not affect the increase in renin mRNA levels. Triiodothyronine 29-45 renin Rattus norvegicus 153-158 9486151-3 1998 Simultaneous incubation with triiodothyronine and the calcium ionophore A-23187 abolished the increase in renin secretion and attenuated the increase in renin content but did not affect the increase in renin mRNA levels. Triiodothyronine 29-45 renin Rattus norvegicus 153-158 9486151-3 1998 Simultaneous incubation with triiodothyronine and the calcium ionophore A-23187 abolished the increase in renin secretion and attenuated the increase in renin content but did not affect the increase in renin mRNA levels. Calcium 54-61 renin Rattus norvegicus 106-111 9486151-3 1998 Simultaneous incubation with triiodothyronine and the calcium ionophore A-23187 abolished the increase in renin secretion and attenuated the increase in renin content but did not affect the increase in renin mRNA levels. Calcium 54-61 renin Rattus norvegicus 153-158 9486151-3 1998 Simultaneous incubation with triiodothyronine and the calcium ionophore A-23187 abolished the increase in renin secretion and attenuated the increase in renin content but did not affect the increase in renin mRNA levels. Calcium 54-61 renin Rattus norvegicus 153-158 9486151-4 1998 During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion. Triiodothyronine 36-52 renin Rattus norvegicus 180-185 9486151-4 1998 During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion. Triiodothyronine 36-52 renin Rattus norvegicus 346-351 9486151-4 1998 During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion. 9-(tetrahydro-2-furyl)-adenine 89-97 renin Rattus norvegicus 180-185 9486151-4 1998 During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion. 9-(tetrahydro-2-furyl)-adenine 89-97 renin Rattus norvegicus 346-351 9486151-4 1998 During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion. Cyclic GMP 118-154 renin Rattus norvegicus 180-185 9486151-4 1998 During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion. Cyclic GMP 156-160 renin Rattus norvegicus 180-185 9486151-4 1998 During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion. Cyclic GMP 156-160 renin Rattus norvegicus 346-351 9486151-4 1998 During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion. Triiodothyronine 265-281 renin Rattus norvegicus 180-185 9486151-4 1998 During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion. Cyclic GMP 302-306 renin Rattus norvegicus 180-185 9461242-8 1998 Measurement of plasma renin concentration and renal renin at pH 6.5 and 8.5, ie, the optimal pH values for rat and mouse renin activities, respectively, indicates that in TGRs the counterregulatory process for renin release elicited by enalapril, losartan, or their combination involves primarily rat renin of renal origin, a finding supported further by the observed increase in the rat renal renin hybridization index. Losartan 247-255 renin Rattus norvegicus 22-27 9524051-4 1998 Pepstatin-eluted renin isoforms were separated by relative molecular size using one-dimensional polyacrylamide gel electrophoresis (SDS-PAGE), or by isoelectric point (pI) and size using two-dimensional (2D) gel electrophoresis. polyacrylamide 96-110 renin Rattus norvegicus 17-22 9461242-5 1998 At the end of the treatment period, enalapril and losartan exerted dose-dependent and, when combined, additive effects in terms of blood pressure fall and cardiac hypertrophy limitation, and synergistic effects in terms of plasma active renin stimulation and blockade of exogenous angiotensin I pressor effects, with E3L3>E3>L3, E1L1>E1> or =L1, and E1L1=E3>L3). Losartan 50-58 renin Rattus norvegicus 237-242 9461242-6 1998 This indicates that in the TGR, (1) the greater the renin-angiotensin system blockade achieved, the greater are the reduction in blood pressure, the limitation of cardiac hypertrophy, and the reactive rise in plasma renin concentration elicited, and (2) the enalapril-losartan combinations are more potent at achieving these goals than any of their constituents individually. Enalapril 258-267 renin Rattus norvegicus 52-57 9461242-6 1998 This indicates that in the TGR, (1) the greater the renin-angiotensin system blockade achieved, the greater are the reduction in blood pressure, the limitation of cardiac hypertrophy, and the reactive rise in plasma renin concentration elicited, and (2) the enalapril-losartan combinations are more potent at achieving these goals than any of their constituents individually. Losartan 268-276 renin Rattus norvegicus 52-57 9461242-8 1998 Measurement of plasma renin concentration and renal renin at pH 6.5 and 8.5, ie, the optimal pH values for rat and mouse renin activities, respectively, indicates that in TGRs the counterregulatory process for renin release elicited by enalapril, losartan, or their combination involves primarily rat renin of renal origin, a finding supported further by the observed increase in the rat renal renin hybridization index. Enalapril 236-245 renin Rattus norvegicus 22-27 9489606-10 1998 5 Ramipril and felodipine in combination increased plasma renin activity by 1.9-3.2 fold without affecting serum aldosterone levels. Ramipril 2-10 renin Rattus norvegicus 58-63 9519246-7 1998 When renin-injected rats were pretreated with captopril, an angiotensin converting enzyme inhibitor, drinking was blocked. Captopril 46-55 renin Rattus norvegicus 5-10 9458851-2 1998 L-NAME treatment induced hypertension that was associated with increased plasma renin activity. NG-Nitroarginine Methyl Ester 0-6 renin Rattus norvegicus 80-85 9489606-10 1998 5 Ramipril and felodipine in combination increased plasma renin activity by 1.9-3.2 fold without affecting serum aldosterone levels. Felodipine 15-25 renin Rattus norvegicus 58-63 9539862-6 1998 Isoproterenol rats were further characterized by hormonal activations including transient elevations of plasma renin activity, aldosterone and cardiac angiotensin converting enzyme activity. Isoproterenol 0-13 renin Rattus norvegicus 111-116 9503033-0 1998 Adrenal renin-angiotensin-aldosterone system in streptozotocin-diabetic rats. Streptozocin 48-62 renin Rattus norvegicus 8-13 9523173-5 1998 Plasma renin activity in the L-Arg group was less than in the CsA (18 +/- 2 vs. 23 +/- 3 ng Ang I/ml/h, p < 0.05) and the L-NAME groups (vs. 30 +/- 3 ng Ang I/ml/h, p < 0.05). Arginine 29-34 renin Rattus norvegicus 7-12 9453303-1 1998 Prostaglandins contribute to the regulation of renin synthesis and secretion. Prostaglandins 0-14 renin Rattus norvegicus 47-52 9503033-1 1998 Previous studies have indicated that the local renin-angiotensin system (RAS) plays an important role in the regulation of aldosterone release. Aldosterone 123-134 renin Rattus norvegicus 47-52 9503033-2 1998 We focused this study on examining the dissociating changes in circulating RAS and adrenal RAS, and we produced a low plasma renin status in streptozotocin (STZ)-induced diabetic rats. Streptozocin 141-155 renin Rattus norvegicus 125-130 9503033-2 1998 We focused this study on examining the dissociating changes in circulating RAS and adrenal RAS, and we produced a low plasma renin status in streptozotocin (STZ)-induced diabetic rats. Streptozocin 157-160 renin Rattus norvegicus 125-130 9627098-1 1998 To elucidate whether and why glucose directly influences renin secretion, the effect of glucose on renin secretion was investigated in the rat. Glucose 88-95 renin Rattus norvegicus 99-104 9533419-0 1998 Sympathetic functions in NG-nitro-L-arginine-methyl-ester-induced hypertension: modulation by the renin-angiotensin system. NG-Nitroarginine Methyl Ester 25-57 renin Rattus norvegicus 98-103 9533419-2 1998 OBJECTIVE: To study sympathetic presynaptic and post-synaptic functions after chronic nitric oxide synthesis blockade with NG-nitro-L-arginine-methyl-ester (L-NAME, for 40 days) in association with renin-angiotensin system blockade (during the last 12 days) in order to evaluate the possible physiological interactions between these systems. NG-Nitroarginine Methyl Ester 123-155 renin Rattus norvegicus 198-203 9933826-7 1998 These results suggest that oral administration of the NEP inhibitor SCH34826 inhibits renal neutral endopeptidase, increases urinary ANP and modulates natriuresis without alteration of systemic blood pressure, plasma ANP and renin level, glomerular filtration or protein excretion. Sch 34826 68-76 renin Rattus norvegicus 225-230 9453330-4 1998 Infusion of renin induced sustained local angiotensin I formation, which was also increased by phenanthroline. Phenanthrolines 95-109 renin Rattus norvegicus 12-17 9453330-8 1998 The pressor response to renin was abolished by the type 1 angiotensin II receptor antagonist losartan. Losartan 93-101 renin Rattus norvegicus 24-29 9533419-2 1998 OBJECTIVE: To study sympathetic presynaptic and post-synaptic functions after chronic nitric oxide synthesis blockade with NG-nitro-L-arginine-methyl-ester (L-NAME, for 40 days) in association with renin-angiotensin system blockade (during the last 12 days) in order to evaluate the possible physiological interactions between these systems. NG-Nitroarginine Methyl Ester 157-163 renin Rattus norvegicus 198-203 9533419-10 1998 CONCLUSIONS: The nitric oxide synthase blockade-induced hypertension seems to be associated with increased adrenal-medullary system and renin-angiotensin system activities. Nitric Oxide 17-29 renin Rattus norvegicus 136-141 9627098-0 1998 Glucose stimulates renin secretion via adrenergic mechanisms in the rat. Glucose 0-7 renin Rattus norvegicus 19-24 9627098-2 1998 In an in vivo study, renin activity significantly (p<0.01) increased from the basal value of 7.6 +/- 1.4 to 14.2 +/- 3.2 ng Ang I/ml/hr (mean +/- SD) after intravenous glucose (1.0 g/kg, in 50% glucose solution ) injection. Glucose 171-178 renin Rattus norvegicus 21-26 9627098-2 1998 In an in vivo study, renin activity significantly (p<0.01) increased from the basal value of 7.6 +/- 1.4 to 14.2 +/- 3.2 ng Ang I/ml/hr (mean +/- SD) after intravenous glucose (1.0 g/kg, in 50% glucose solution ) injection. Glucose 197-204 renin Rattus norvegicus 21-26 9627098-3 1998 Propranolol (10.5 mg/kg) pretreatment partly abolished the increase in renin activity induced by glucose injection. Propranolol 0-11 renin Rattus norvegicus 71-76 9627098-3 1998 Propranolol (10.5 mg/kg) pretreatment partly abolished the increase in renin activity induced by glucose injection. Glucose 97-104 renin Rattus norvegicus 71-76 9627098-5 1998 Renin activity was significantly increased from a basal value of 8.1 +/- 4.5 to peak value of 17.9 +/- 3.0 ng Ang I/ml/hr (p<0.01) by 16.5 mM glucose, to 59.0 +/- 10.5 ng Ang I/ml/hr (p<0.005) by 27.5 mM glucose, and to 24.7 +/- 5.8 ng Ang I/ml/hr (p<0.01) by 5.5 mM glucose + 22 mM mannitol. Glucose 145-152 renin Rattus norvegicus 0-5 9627098-5 1998 Renin activity was significantly increased from a basal value of 8.1 +/- 4.5 to peak value of 17.9 +/- 3.0 ng Ang I/ml/hr (p<0.01) by 16.5 mM glucose, to 59.0 +/- 10.5 ng Ang I/ml/hr (p<0.005) by 27.5 mM glucose, and to 24.7 +/- 5.8 ng Ang I/ml/hr (p<0.01) by 5.5 mM glucose + 22 mM mannitol. Glucose 210-217 renin Rattus norvegicus 0-5 9627098-5 1998 Renin activity was significantly increased from a basal value of 8.1 +/- 4.5 to peak value of 17.9 +/- 3.0 ng Ang I/ml/hr (p<0.01) by 16.5 mM glucose, to 59.0 +/- 10.5 ng Ang I/ml/hr (p<0.005) by 27.5 mM glucose, and to 24.7 +/- 5.8 ng Ang I/ml/hr (p<0.01) by 5.5 mM glucose + 22 mM mannitol. Glucose 210-217 renin Rattus norvegicus 0-5 9627098-5 1998 Renin activity was significantly increased from a basal value of 8.1 +/- 4.5 to peak value of 17.9 +/- 3.0 ng Ang I/ml/hr (p<0.01) by 16.5 mM glucose, to 59.0 +/- 10.5 ng Ang I/ml/hr (p<0.005) by 27.5 mM glucose, and to 24.7 +/- 5.8 ng Ang I/ml/hr (p<0.01) by 5.5 mM glucose + 22 mM mannitol. Mannitol 292-300 renin Rattus norvegicus 0-5 9627098-6 1998 The increase in renin activity in the kidney perfused with 27.5 mM glucose was significantly (p<0.005) higher than that with 16.5 mM glucose or that with 5.5 mM glucose + 22 mM mannitol. Glucose 67-74 renin Rattus norvegicus 16-21 9627098-6 1998 The increase in renin activity in the kidney perfused with 27.5 mM glucose was significantly (p<0.005) higher than that with 16.5 mM glucose or that with 5.5 mM glucose + 22 mM mannitol. Glucose 136-143 renin Rattus norvegicus 16-21 9627098-6 1998 The increase in renin activity in the kidney perfused with 27.5 mM glucose was significantly (p<0.005) higher than that with 16.5 mM glucose or that with 5.5 mM glucose + 22 mM mannitol. Glucose 136-143 renin Rattus norvegicus 16-21 9627098-6 1998 The increase in renin activity in the kidney perfused with 27.5 mM glucose was significantly (p<0.005) higher than that with 16.5 mM glucose or that with 5.5 mM glucose + 22 mM mannitol. Mannitol 180-188 renin Rattus norvegicus 16-21 9627098-7 1998 The 27.5 mM glucose-stimulated increase in renin activity was not changed by the addition of 1 microM phentolamine, while it was completely abolished by the addition of 1 microM propranolol. Glucose 12-19 renin Rattus norvegicus 43-48 9627098-7 1998 The 27.5 mM glucose-stimulated increase in renin activity was not changed by the addition of 1 microM phentolamine, while it was completely abolished by the addition of 1 microM propranolol. Phentolamine 102-114 renin Rattus norvegicus 43-48 9627098-7 1998 The 27.5 mM glucose-stimulated increase in renin activity was not changed by the addition of 1 microM phentolamine, while it was completely abolished by the addition of 1 microM propranolol. Propranolol 178-189 renin Rattus norvegicus 43-48 9627098-8 1998 These results suggest that glucose has a direct stimulating effect on renin secretion probably through beta-adrenergic mechanisms in the rat. Glucose 27-34 renin Rattus norvegicus 70-75 9509561-3 1998 The purpose of this work was to evaluate in a rat model of experimental cirrhosis (phenobarbital/CCl4) the role of the renin-angiotensin system in the pre-ascitic stage of the disease using the converting enzyme inhibitor captopril. Captopril 222-231 renin Rattus norvegicus 119-124 9422427-10 1997 Since both peripheral and tissue renin expression were elevated with FK506, the renin-angiotensin system may play a role in the pathogenesis of this condition. Tacrolimus 69-74 renin Rattus norvegicus 33-38 9422427-10 1997 Since both peripheral and tissue renin expression were elevated with FK506, the renin-angiotensin system may play a role in the pathogenesis of this condition. Tacrolimus 69-74 renin Rattus norvegicus 80-85 9435677-0 1997 Regulation of glomerular and proximal tubule renin mRNA by chronic changes in dietary NaCl. Sodium Chloride 86-90 renin Rattus norvegicus 45-50 9405684-4 1997 Supplemental KCl, but not KB/C, induced strokes, which occurred in all and only those rats in the highest quartiles of both BP and plasma renin activity (PRA). Potassium Chloride 13-16 renin Rattus norvegicus 138-143 9435677-4 1997 After 4 days of the diets, glomerular renin mRNA abundance was increased 100% by the low-NaCl diet (P < 0.05) and suppressed 50% (P < 0.01) by the high NaCl diet compared with controls. Sodium Chloride 158-162 renin Rattus norvegicus 38-43 9435677-4 1997 After 4 days of the diets, glomerular renin mRNA abundance was increased 100% by the low-NaCl diet (P < 0.05) and suppressed 50% (P < 0.01) by the high NaCl diet compared with controls. Sodium Chloride 89-93 renin Rattus norvegicus 38-43 9435677-5 1997 Renin mRNA in proximal tubules was stimulated 230% (P < 0.05) by the low-NaCl diet and tended to be suppressed (68% decrease, not significant) by the high-NaCl diet. Sodium Chloride 76-80 renin Rattus norvegicus 0-5 9435677-5 1997 Renin mRNA in proximal tubules was stimulated 230% (P < 0.05) by the low-NaCl diet and tended to be suppressed (68% decrease, not significant) by the high-NaCl diet. Sodium Chloride 158-162 renin Rattus norvegicus 0-5 9435677-6 1997 When the high-NaCl diet was continued for 2 wk, proximal tubule renin mRNA was suppressed by 89% (P < 0.05). Sodium Chloride 14-18 renin Rattus norvegicus 64-69 9435677-7 1997 This study provides evidence that glomerular and proximal tubule renin transcript levels are regulated by chronic changes in dietary NaCl, suggesting that local RASs contribute to the renal adaptations in response to chronic alterations in NaCl. Sodium Chloride 133-137 renin Rattus norvegicus 65-70 9435677-7 1997 This study provides evidence that glomerular and proximal tubule renin transcript levels are regulated by chronic changes in dietary NaCl, suggesting that local RASs contribute to the renal adaptations in response to chronic alterations in NaCl. Sodium Chloride 240-244 renin Rattus norvegicus 65-70 9407461-8 1997 Administration of Ang II type 1 receptor (AT-1) antagonist TCV-116 significantly increased PRA, plasma Ang II, and the number of renin-positive glomeruli. candesartan cilexetil 59-66 renin Rattus norvegicus 129-134 9407461-5 1997 In the low-salt group, PRA, plasma Ang II, and the number of renin and NOS-I positively stained areas in the juxtaglomerular apparatus (JGA) were all increased, while BP and NOS-III in the glomerular capillaries did not change. Salts 11-15 renin Rattus norvegicus 61-66 9421286-21 1997 Attenuation of the response to GR138950 or enalapril, but not hydralazine, suggests a selective interaction between L-NAME and inhibitors of the renin-angiotensin system, although the nature of this interaction is unknown. saprisartan potassium 31-39 renin Rattus norvegicus 145-150 9421286-21 1997 Attenuation of the response to GR138950 or enalapril, but not hydralazine, suggests a selective interaction between L-NAME and inhibitors of the renin-angiotensin system, although the nature of this interaction is unknown. Enalapril 43-52 renin Rattus norvegicus 145-150 9421286-21 1997 Attenuation of the response to GR138950 or enalapril, but not hydralazine, suggests a selective interaction between L-NAME and inhibitors of the renin-angiotensin system, although the nature of this interaction is unknown. NG-Nitroarginine Methyl Ester 116-122 renin Rattus norvegicus 145-150 9431853-3 1997 To examine the role of renal sympathetic nerves in the stimulation of the renin system by losartan, left kidneys were denervated 4 days prior to the treatment with losartan. Losartan 90-98 renin Rattus norvegicus 74-79 9431853-4 1997 Also, to examine the role of circulating catecholamines in the stimulation of the renin system by losartan, the animals were administered a combination treatment of losartan with the beta1-adrenoreceptor blocker metoprolol (50 mg/kg per day) for 3 days. Losartan 98-106 renin Rattus norvegicus 82-87 9431853-5 1997 RESULTS: Losartan treatment increased plasma renin activity about sevenfold and renal renin messenger RNA (mRNA) levels about fivefold and decreased systolic blood pressure from 118 to 95 mmHg. Losartan 9-17 renin Rattus norvegicus 45-50 9431853-5 1997 RESULTS: Losartan treatment increased plasma renin activity about sevenfold and renal renin messenger RNA (mRNA) levels about fivefold and decreased systolic blood pressure from 118 to 95 mmHg. Losartan 9-17 renin Rattus norvegicus 86-91 9431853-6 1997 Administration of losartan elevated renin mRNA both in the innervated and in the denervated kidneys to the same level as it did in kidneys of normal animals. Losartan 18-26 renin Rattus norvegicus 36-41 9431853-7 1997 Losartan treatment increased plasma renin activity and renal renin mRNA levels in the beta1-blocker-treated rats to the same extent as it did in animals administered losartan only. Losartan 0-8 renin Rattus norvegicus 36-41 9431853-7 1997 Losartan treatment increased plasma renin activity and renal renin mRNA levels in the beta1-blocker-treated rats to the same extent as it did in animals administered losartan only. Losartan 0-8 renin Rattus norvegicus 61-66 9431854-12 1997 The ability of adrenergic agonists to stimulate the renin system appears to be modulated by the steady-state level of salt intake. Salts 118-122 renin Rattus norvegicus 52-57 9386177-4 1997 When approximately equipotent regimens of enalapril, losartan, and their combination, as judged by BP fall, were compared, there were similar increases in plasma and renal renin and in plasma Ang-(1-7) and Ang I and similar reductions in plasma angiotensinogen. Enalapril 42-51 renin Rattus norvegicus 172-177 9386177-7 1997 CONCLUSIONS: These findings show that the synergistic interaction between the effects of low doses of enalapril and losartan on BP and LVW/BW ratio is due to more effective inhibition of the renin-angiotensin system by their combination than by either agent alone. Enalapril 102-111 renin Rattus norvegicus 191-196 9351460-5 1997 In intact rats, plasma renin activity (PRA) and adrenal renin activity and expression were progressively raised by salt restriction and losartan, whereas aldosterone synthase mRNA and plasma aldosterone (PA) levels were increased by salt restriction and reduced by losartan. Salts 115-119 renin Rattus norvegicus 23-28 9386177-7 1997 CONCLUSIONS: These findings show that the synergistic interaction between the effects of low doses of enalapril and losartan on BP and LVW/BW ratio is due to more effective inhibition of the renin-angiotensin system by their combination than by either agent alone. Losartan 116-124 renin Rattus norvegicus 191-196 9351460-5 1997 In intact rats, plasma renin activity (PRA) and adrenal renin activity and expression were progressively raised by salt restriction and losartan, whereas aldosterone synthase mRNA and plasma aldosterone (PA) levels were increased by salt restriction and reduced by losartan. Salts 115-119 renin Rattus norvegicus 56-61 9351460-5 1997 In intact rats, plasma renin activity (PRA) and adrenal renin activity and expression were progressively raised by salt restriction and losartan, whereas aldosterone synthase mRNA and plasma aldosterone (PA) levels were increased by salt restriction and reduced by losartan. Losartan 136-144 renin Rattus norvegicus 23-28 9351460-5 1997 In intact rats, plasma renin activity (PRA) and adrenal renin activity and expression were progressively raised by salt restriction and losartan, whereas aldosterone synthase mRNA and plasma aldosterone (PA) levels were increased by salt restriction and reduced by losartan. Losartan 136-144 renin Rattus norvegicus 56-61 9351460-7 1997 Also, adrenal renin activity was raised after nephrectomy and further increased after salt restriction (P < .05) and losartan. Salts 86-90 renin Rattus norvegicus 14-19 9351460-7 1997 Also, adrenal renin activity was raised after nephrectomy and further increased after salt restriction (P < .05) and losartan. Losartan 120-128 renin Rattus norvegicus 14-19 9388051-11 1997 We conclude that angiotensin-(1-7) is a component of the renin-angiotensin system that acts to modulate the pressor effects of angiotensin II and noradrenaline. Norepinephrine 146-159 renin Rattus norvegicus 57-62 9441733-0 1997 Effect of repeated administration of cadmium, captopril and its combination on plasma renin activity in rats. Cadmium 37-44 renin Rattus norvegicus 86-91 9441733-0 1997 Effect of repeated administration of cadmium, captopril and its combination on plasma renin activity in rats. Captopril 46-55 renin Rattus norvegicus 86-91 9353378-7 1997 These results suggested that a high-salt content diet and the renin-angiotensin system are deterioration factors in lethal renal damage and the limitation of the diet salt content and inhibition of the renin-angiotensin system are important to improve the survival rate in high-salt-loaded hypertensive Dahl salt-sensitive rats. Salts 36-40 renin Rattus norvegicus 62-67 9353378-7 1997 These results suggested that a high-salt content diet and the renin-angiotensin system are deterioration factors in lethal renal damage and the limitation of the diet salt content and inhibition of the renin-angiotensin system are important to improve the survival rate in high-salt-loaded hypertensive Dahl salt-sensitive rats. Salts 36-40 renin Rattus norvegicus 202-207 9353378-7 1997 These results suggested that a high-salt content diet and the renin-angiotensin system are deterioration factors in lethal renal damage and the limitation of the diet salt content and inhibition of the renin-angiotensin system are important to improve the survival rate in high-salt-loaded hypertensive Dahl salt-sensitive rats. Salts 167-171 renin Rattus norvegicus 62-67 9353378-7 1997 These results suggested that a high-salt content diet and the renin-angiotensin system are deterioration factors in lethal renal damage and the limitation of the diet salt content and inhibition of the renin-angiotensin system are important to improve the survival rate in high-salt-loaded hypertensive Dahl salt-sensitive rats. Salts 167-171 renin Rattus norvegicus 62-67 9353378-7 1997 These results suggested that a high-salt content diet and the renin-angiotensin system are deterioration factors in lethal renal damage and the limitation of the diet salt content and inhibition of the renin-angiotensin system are important to improve the survival rate in high-salt-loaded hypertensive Dahl salt-sensitive rats. Salts 167-171 renin Rattus norvegicus 62-67 9357928-6 1997 Enalapril decreased renal TGF-beta1 and EGF mRNA expression, and increased renal clusterin and renin expression (p < 0.05). Enalapril 0-9 renin Rattus norvegicus 95-100 9353588-4 1997 Sodium or chloride depletion decreased plasma levels of atrial natriuretic peptide, increased plasma renin activity, and induced extracellular fluid volume contraction. Sodium 0-6 renin Rattus norvegicus 101-106 18982478-5 1997 These results suggest that nitric oxide interacts with renin angiotensin system to control the pulmonary vascular tension and pulmonary arterial circulation of RHR. Nitric Oxide 27-39 renin Rattus norvegicus 55-60 9353588-4 1997 Sodium or chloride depletion decreased plasma levels of atrial natriuretic peptide, increased plasma renin activity, and induced extracellular fluid volume contraction. Chlorides 10-18 renin Rattus norvegicus 101-106 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Histidine 22-25 renin Rattus norvegicus 124-129 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Proline 26-29 renin Rattus norvegicus 124-129 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Phenylalanine 30-33 renin Rattus norvegicus 124-129 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Histidine 34-37 renin Rattus norvegicus 124-129 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Leucine 38-41 renin Rattus norvegicus 124-129 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Leucine 56-59 renin Rattus norvegicus 124-129 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Tyrosine 60-63 renin Rattus norvegicus 124-129 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Tyrosine 64-67 renin Rattus norvegicus 124-129 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Serine 68-71 renin Rattus norvegicus 124-129 9352462-2 1997 In vitro, peptide Piv-His-Pro-Phe-His-Leu-psi[CH(OH)CH2]Leu-Tyr-Tyr-Ser-NH2(XXI) is the most potent inhibitor of rat plasma renin reported having an IC50 of 0.21 nM; it is a much weaker inhibitor of human renin (IC50 45 nM). Amido radical 72-75 renin Rattus norvegicus 124-129 9352462-3 1997 Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo. Histidine 12-15 renin Rattus norvegicus 112-117 9352462-3 1997 Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo. Proline 16-19 renin Rattus norvegicus 112-117 9352462-3 1997 Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo. Phenylalanine 20-23 renin Rattus norvegicus 112-117 9352462-3 1997 Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo. Histidine 24-27 renin Rattus norvegicus 112-117 9352462-3 1997 Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo. Leucine 28-31 renin Rattus norvegicus 112-117 9352462-3 1997 Peptide Boc-His-Pro-Phe-His-Leu-psi[CH(OH)CH2] Leu-Val-Ile-His-NH2 (XX) was a highly effective inhibitor of rat renin in vivo. Histidine 24-27 renin Rattus norvegicus 112-117 9439779-1 1997 The aim of the present study was to provide an overview of the role of circulating gonadal steroids on the adaptive changes of the renin-angiotensin system to chronic hypobaric hypoxia (CHH: 4400 m simulated altitude in an hypobaric chamber) and the development of experimental hypertension by bilateral renal ischemia. Steroids 91-99 renin Rattus norvegicus 131-136 9336386-0 1997 Enalapril and renal function in hypertensive rats transgenic for mouse renin gene. Enalapril 0-9 renin Rattus norvegicus 71-76 9336386-8 1997 The mechanism of the beneficial effect of enalapril on the TGR(mRen2)27 kidney is unclear but could involve either control of hypertension or suppression of the intrarenal renin-angiotensin system. Enalapril 42-51 renin Rattus norvegicus 172-177 9323291-6 1997 Compared with controls, plasma renin activity was unchanged in puppies and adults with L-Name, undetectable in puppies and slightly increased in adults with perindopril, undetectable in puppies and slightly decreased in adults with perindopril plus L-Name. NG-Nitroarginine Methyl Ester 87-93 renin Rattus norvegicus 31-36 9323291-6 1997 Compared with controls, plasma renin activity was unchanged in puppies and adults with L-Name, undetectable in puppies and slightly increased in adults with perindopril, undetectable in puppies and slightly decreased in adults with perindopril plus L-Name. Perindopril 157-168 renin Rattus norvegicus 31-36 9323291-6 1997 Compared with controls, plasma renin activity was unchanged in puppies and adults with L-Name, undetectable in puppies and slightly increased in adults with perindopril, undetectable in puppies and slightly decreased in adults with perindopril plus L-Name. Perindopril 232-243 renin Rattus norvegicus 31-36 9323291-6 1997 Compared with controls, plasma renin activity was unchanged in puppies and adults with L-Name, undetectable in puppies and slightly increased in adults with perindopril, undetectable in puppies and slightly decreased in adults with perindopril plus L-Name. NG-Nitroarginine Methyl Ester 249-255 renin Rattus norvegicus 31-36 9439779-5 1997 Results suggest that circulating sexual steroid hormones are involved in the response of the renin-angiotensin system to the experimental conditions of environmental reduced O2 partial pressure. Steroids 40-47 renin Rattus norvegicus 93-98 9439779-5 1997 Results suggest that circulating sexual steroid hormones are involved in the response of the renin-angiotensin system to the experimental conditions of environmental reduced O2 partial pressure. Oxygen 174-176 renin Rattus norvegicus 93-98 9328799-9 1997 Plasma renin activity was markedly increased by L-NAME treatment and decreased by the high-salt diet. NG-Nitroarginine Methyl Ester 48-54 renin Rattus norvegicus 7-12 9342414-3 1997 Study 2: In salt-loaded Dahl S rats with a suppressed plasma renin activity treatment with BAY 10-6734 did not delay the increase in blood pressure but prevented cardiac hypertrophy and the increase in plasma ANP (Atrial natriuretic peptide). Salts 12-16 renin Rattus norvegicus 61-66 9342414-3 1997 Study 2: In salt-loaded Dahl S rats with a suppressed plasma renin activity treatment with BAY 10-6734 did not delay the increase in blood pressure but prevented cardiac hypertrophy and the increase in plasma ANP (Atrial natriuretic peptide). embusartan 91-102 renin Rattus norvegicus 61-66 9314425-0 1997 Nitric oxide synthase and renin-angiotensin system gene expression in salt-sensitive and salt-resistant Sabra rats. Salts 70-74 renin Rattus norvegicus 26-50 9314425-0 1997 Nitric oxide synthase and renin-angiotensin system gene expression in salt-sensitive and salt-resistant Sabra rats. Salts 89-93 renin Rattus norvegicus 26-50 9322982-4 1997 In salt-restricted, nephrectomized rats, losartan administration caused increases of adrenal renin mRNA (P<.05) and activity (P<.05) and a concomitant reduction of aldosterone synthase mRNA (P<.05). Losartan 41-49 renin Rattus norvegicus 93-98 9322982-7 1997 In conclusion, in salt-restricted, nephrectomized rats, selective antagonism of AT1-subtype receptors stimulates the expression and the activity of renin in the adrenal cortex. Salts 18-22 renin Rattus norvegicus 148-153 9328799-9 1997 Plasma renin activity was markedly increased by L-NAME treatment and decreased by the high-salt diet. Salts 91-95 renin Rattus norvegicus 7-12 9314425-0 1997 Nitric oxide synthase and renin-angiotensin system gene expression in salt-sensitive and salt-resistant Sabra rats. sabra 104-109 renin Rattus norvegicus 26-50 9271663-1 1997 The renin locus (Ren) on rat Chromosome (Chr) 13 had previously been shown to cosegregate with blood pressure in crosses involving Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. dahl salt 131-140 renin Rattus norvegicus 4-9 9314425-7 1997 After DOCA-salt treatment, renin gene expression was strongly suppressed in both strains but more so in SBH/y. Desoxycorticosterone Acetate 6-10 renin Rattus norvegicus 27-32 9314425-7 1997 After DOCA-salt treatment, renin gene expression was strongly suppressed in both strains but more so in SBH/y. Salts 11-15 renin Rattus norvegicus 27-32 9314425-11 1997 We conclude that DOCA salt induced a decrease in the activity of the renin-angiotensin system but did not change NO synthase gene expression in SBH/y and SBN/y. doca salt 17-26 renin Rattus norvegicus 69-93 9300315-8 1997 Spirapril alone reduced blood pressure and increased PRA and when given before 2HE-NECA potentiated its depressor and renin-stimulating effects by 44% and 69%, respectively. spirapril 0-9 renin Rattus norvegicus 118-123 9271663-1 1997 The renin locus (Ren) on rat Chromosome (Chr) 13 had previously been shown to cosegregate with blood pressure in crosses involving Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. dahl salt 131-140 renin Rattus norvegicus 17-20 9271663-1 1997 The renin locus (Ren) on rat Chromosome (Chr) 13 had previously been shown to cosegregate with blood pressure in crosses involving Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. dahl salt 159-168 renin Rattus norvegicus 4-9 9271663-1 1997 The renin locus (Ren) on rat Chromosome (Chr) 13 had previously been shown to cosegregate with blood pressure in crosses involving Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. dahl salt 159-168 renin Rattus norvegicus 17-20 9270081-6 1997 Iganidipine at all doses examined increased the urinary prostaglandin (PG) I2 and PGE2, but not PGF2alpha or thromboxane B2, and decreased plasma angiotensin II (AII) level and renin activity. iganidipine 0-11 renin Rattus norvegicus 177-182 9311659-6 1997 Blockade of the renin-angiotensin system with enalapril or L-158,809 significantly delayed the onset of stroke (19+/-2 and 20+/-2 days, respectively), but caused only slight reductions in mean arterial blood pressure. Enalapril 46-55 renin Rattus norvegicus 16-21 9311659-6 1997 Blockade of the renin-angiotensin system with enalapril or L-158,809 significantly delayed the onset of stroke (19+/-2 and 20+/-2 days, respectively), but caused only slight reductions in mean arterial blood pressure. l-158 59-64 renin Rattus norvegicus 16-21 9298943-2 1997 The linear, hydrophobic pseudo-hexapeptide ditekiren, a renin inhibitor, is one such example. ditekiren 43-52 renin Rattus norvegicus 56-61 9404423-4 1997 In the plasma, both renin activity and angiotensin I increased 10 to 15 fold one to four hours after acute as well as at Day 14 of ramipril treatment and then returned to basal values within 24 hours. Ramipril 131-139 renin Rattus norvegicus 20-25 9404423-7 1997 In the renal cortex and medulla, a clearly different pattern was observed: in ramipril treated rats, renin activity in the renal cortex and medulla did not change at Day 1 but at Day 14 we observed a slight and sustained increase in renin activity. Ramipril 78-86 renin Rattus norvegicus 101-106 9404423-7 1997 In the renal cortex and medulla, a clearly different pattern was observed: in ramipril treated rats, renin activity in the renal cortex and medulla did not change at Day 1 but at Day 14 we observed a slight and sustained increase in renin activity. Ramipril 78-86 renin Rattus norvegicus 233-238 9273895-0 1997 New renin inhibitors containing novel analogues of statine. statine 51-58 renin Rattus norvegicus 4-9 9280208-7 1997 CONCLUSION: That Ang II levels are elevated in sucrose-induced hypertension and decreased after vanadium therapy suggests that the renin-angiotensin system plays a role in the induction of hypertension in this model. Sucrose 47-54 renin Rattus norvegicus 131-136 9280208-7 1997 CONCLUSION: That Ang II levels are elevated in sucrose-induced hypertension and decreased after vanadium therapy suggests that the renin-angiotensin system plays a role in the induction of hypertension in this model. Vanadium 96-104 renin Rattus norvegicus 131-136 9260990-4 1997 Two minutes after BNX and corresponding stimulation of renin secretion by anesthesia and surgery, plasma renin concentration was increased disproportionately compared with myocardial renin. benoxinate 18-21 renin Rattus norvegicus 105-110 9260990-4 1997 Two minutes after BNX and corresponding stimulation of renin secretion by anesthesia and surgery, plasma renin concentration was increased disproportionately compared with myocardial renin. benoxinate 18-21 renin Rattus norvegicus 105-110 9260990-5 1997 Three, 6, and 48 hours after BNX, renin decay occurred significantly faster from the plasma than from the myocardium. benoxinate 29-32 renin Rattus norvegicus 34-39 9260990-6 1997 Forty-eight hours after BNX, myocardial renin concentrations had fallen to 15% of control values, while myocardial angiotensinogen concentrations had increased 12-fold and plasma angiotensinogen concentrations had increased by only 3.5-fold. benoxinate 24-27 renin Rattus norvegicus 40-45 9260990-8 1997 At 6 hours BNX, the proportions of plasma active renin glycoforms I+II fell, while those in the myocardium significantly increased. benoxinate 11-14 renin Rattus norvegicus 49-54 9260990-10 1997 After BNX, myocardial renin concentration falls dramatically, suggesting that most cardiac renin is derived from plasma renin of renal origin. benoxinate 6-9 renin Rattus norvegicus 91-96 9260990-10 1997 After BNX, myocardial renin concentration falls dramatically, suggesting that most cardiac renin is derived from plasma renin of renal origin. benoxinate 6-9 renin Rattus norvegicus 91-96 9260993-1 1997 As interactions between the renin-angiotensin and sympathetic nervous systems have been suggested in the pathogenesis of hypertension, we wanted to investigate the effect of chronic renin-angiotensin blockade with losartan and enalaprilat on the sympathetic reactivity to hypotension and on the cardiac beta-adrenergic-coupled adenylyl cyclase pathway in 12-week-old Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Losartan 214-222 renin Rattus norvegicus 182-187 9291846-6 1997 STZ treatment decreased plasma angiotensinogen by 72% (4 weeks) and 67% (12 weeks) and increased plasma renin concentration after 12 weeks; plasma renin activity and aldosterone concentrations remained unchanged. Streptozocin 0-3 renin Rattus norvegicus 104-109 9291846-9 1997 Plasma angiotensinogen and renin secretion change in directions that result in the maintenance of plasma renin activity and aldosterone concentration. Aldosterone 124-135 renin Rattus norvegicus 27-32 9273895-2 1997 The synthesis of these novel analogues of statine together with biological results on the inhibition of human and rat renin by peptides derived from them is reported. statine 42-49 renin Rattus norvegicus 118-123 9273895-5 1997 However, peptides containing Ads and Amd gave better rat renin inhibitors than the corresponding Sta-containing peptides. Peptides 9-17 renin Rattus norvegicus 57-62 9273895-6 1997 Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin. Histidine 13-16 renin Rattus norvegicus 114-119 9273895-6 1997 Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin. Proline 17-20 renin Rattus norvegicus 114-119 9273895-6 1997 Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin. Phenylalanine 21-24 renin Rattus norvegicus 114-119 9273895-6 1997 Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin. Histidine 25-28 renin Rattus norvegicus 114-119 9273895-6 1997 Peptides Boc-His-Pro-Phe-His-Ads-Val-Ile-His-NH2 (VII) having Ads at position 10 had an IC50 of 12 nM against rat renin. Histidine 25-28 renin Rattus norvegicus 114-119 9253950-16 1997 In conclusion, differential effects of sulindac on renal hemodynamics, Na+ excretion and plasma renin activity were demonstrated. Sulindac 39-47 renin Rattus norvegicus 96-101 9258997-3 1997 Both acute and chronic captopril in combination with BK caused a large increase in plasma renin activity. Captopril 23-32 renin Rattus norvegicus 90-95 9218502-18 1997 These data demonstrate that activation of the renin- angiotensin system during sodium depletion increases renal nitric oxide production through stimulation by Ang II at the angiotensin AT2 receptor. Sodium 79-85 renin Rattus norvegicus 46-51 9218502-18 1997 These data demonstrate that activation of the renin- angiotensin system during sodium depletion increases renal nitric oxide production through stimulation by Ang II at the angiotensin AT2 receptor. Nitric Oxide 112-124 renin Rattus norvegicus 46-51 9247770-1 1997 The effectiveness of antisense oligonucleotides (ODNs) to angiotensinogen on intracerebrovenricularly injected renin induced thirst was investigated. Oligonucleotides 31-47 renin Rattus norvegicus 111-116 9214404-16 1997 Since sodium depletion elevates peripheral renin activity, our experiments suggest a role for the renin-angiotensin system in the expression of TGF-beta1 and matrix proteins in CsA-induced renal fibrosis of rats on a LSD. Sodium 6-12 renin Rattus norvegicus 43-48 9214404-16 1997 Since sodium depletion elevates peripheral renin activity, our experiments suggest a role for the renin-angiotensin system in the expression of TGF-beta1 and matrix proteins in CsA-induced renal fibrosis of rats on a LSD. Sodium 6-12 renin Rattus norvegicus 98-103 9247770-5 1997 Antisense significantly reduced (by about 50%) the volume of water drunk in response to intracerebroventricular (icv) renin or isoproterenol but did not reduce drinking in response to the physiological challenge of icv angiotensin II, icv carbachol, intravenous hypertonic saline, water deprivation or subcutaneous injection of polyethylene glycol. Water 61-66 renin Rattus norvegicus 118-123 9228197-8 1997 Moxonidine increased plasma renin activity during the control diet and it raised the serum aldosterone level both during the control and mineral salt diets. moxonidine 0-10 renin Rattus norvegicus 28-33 9171961-2 1997 Stimulation of the gastric sodium monitor has been reported to cause a decrease in renal nerve activity and also a decrease in plasma renin activity in renal venous blood. Sodium 27-33 renin Rattus norvegicus 134-139 9179393-18 1997 Ramipril treatment, both alone and in combination with felodipine, caused a three fold increase in plasma renin activity. Ramipril 0-8 renin Rattus norvegicus 106-111 9179393-18 1997 Ramipril treatment, both alone and in combination with felodipine, caused a three fold increase in plasma renin activity. Felodipine 55-65 renin Rattus norvegicus 106-111 9168786-6 1997 When low-renin low-Ang II hypertension was induced in Dahl salt-sensitive rats, there was no detectable increase in the expression of aortic thrombin receptor mRNA. dahl salt 54-63 renin Rattus norvegicus 9-14 9171957-16 1997 Activation of the renin-angiotensin system may account, at least in part, for the resulting vasoconstrictor activity with chronic nitric oxide depletion. Nitric Oxide 130-142 renin Rattus norvegicus 18-23 9171961-3 1997 This suggests that changes in sympathetic nerve activity and in the intrarenal renin-angiotensin system may mediate the natriuresis that occurs following gastric sodium administration. Sodium 162-168 renin Rattus norvegicus 79-84 9680296-0 1997 Evaluation of the renin-angiotensin system in a congenic renin Dahl salt-sensitive rat. dahl salt 63-72 renin Rattus norvegicus 18-23 9225731-0 1997 Role of the renin-angiotensin system in the development of thyroxine-induced hypertension. Thyroxine 59-68 renin Rattus norvegicus 12-17 9225731-1 1997 OBJECTIVE: We evaluated the influence of chronic blockade of the renin-angiotensin system on hypertension induced by long-term thyroxin (T4) administration. Thyroxine 127-135 renin Rattus norvegicus 65-70 9680296-1 1997 When an approximately 30 centiMorgan (cM) region of chromosome 13 containing the renin gene from the Dahl salt-resistant rat (R) was introgressed into the Dahl salt-sensitive rat (S), the resulting congenic rat (designated S.R-Ren) had a systolic blood pressure on a 2% (w/w) salt diet that was 24 mmHg lower than that of its S counterpart. Salts 106-110 renin Rattus norvegicus 81-86 9225020-9 1997 It is concluded that nitrite decreases blood pressure in rats, which probably induces, by renin-angiotensin system activation, hypertrophy of the adrenal zona glomerulosa. Nitrites 21-28 renin Rattus norvegicus 90-95 9680296-1 1997 When an approximately 30 centiMorgan (cM) region of chromosome 13 containing the renin gene from the Dahl salt-resistant rat (R) was introgressed into the Dahl salt-sensitive rat (S), the resulting congenic rat (designated S.R-Ren) had a systolic blood pressure on a 2% (w/w) salt diet that was 24 mmHg lower than that of its S counterpart. dahl salt 101-110 renin Rattus norvegicus 81-86 9136670-2 1997 To this end the renin system in male Sprague Dawley rats was stimulated by unilateral renal artery clipping (0.2 mm clip), by furosemide (60 mg/kg per diem) or isoproterenol (160 microg/kg per diem), and by ingestion of a low-salt diet (0.02%), or was suppressed by setting a contralateral renal artery clip (0.2-mm clip) or by ingestion of a high-salt diet (4%). Furosemide 126-136 renin Rattus norvegicus 16-21 9186867-0 1997 Activation of renin synthesis is dependent on intact nitric oxide production. Nitric Oxide 53-65 renin Rattus norvegicus 14-19 9186867-5 1997 In afferent arterioles isolated from rats treated with the angiotensin-converting enzyme inhibitor ramipril, renin mRNA levels, total renin content and renin secretion were increased threefold compared to untreated controls. Ramipril 99-107 renin Rattus norvegicus 109-114 9186867-6 1997 Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. NG-Nitroarginine Methyl Ester 29-61 renin Rattus norvegicus 127-132 9186867-6 1997 Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. NG-Nitroarginine Methyl Ester 29-61 renin Rattus norvegicus 152-157 9186867-6 1997 Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. NG-Nitroarginine Methyl Ester 29-61 renin Rattus norvegicus 152-157 9186867-6 1997 Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. NG-Nitroarginine Methyl Ester 63-69 renin Rattus norvegicus 127-132 9186867-6 1997 Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. NG-Nitroarginine Methyl Ester 63-69 renin Rattus norvegicus 152-157 9186867-6 1997 Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. NG-Nitroarginine Methyl Ester 63-69 renin Rattus norvegicus 152-157 9186867-6 1997 Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. Ramipril 78-86 renin Rattus norvegicus 127-132 9186867-6 1997 Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. Ramipril 78-86 renin Rattus norvegicus 152-157 9186867-6 1997 Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. Ramipril 78-86 renin Rattus norvegicus 152-157 9186867-7 1997 In other animals furosemide, a diuretic acting on macula densa cells, activated renin synthesis to a level similar to that found in the ramipril-treated group. Furosemide 17-27 renin Rattus norvegicus 80-85 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. NG-Nitroarginine Methyl Ester 12-18 renin Rattus norvegicus 78-83 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. NG-Nitroarginine Methyl Ester 12-18 renin Rattus norvegicus 103-108 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. NG-Nitroarginine Methyl Ester 12-18 renin Rattus norvegicus 103-108 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. NG-Nitroarginine Methyl Ester 12-18 renin Rattus norvegicus 103-108 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. Furosemide 26-36 renin Rattus norvegicus 78-83 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. Furosemide 26-36 renin Rattus norvegicus 103-108 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. Furosemide 26-36 renin Rattus norvegicus 103-108 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. Furosemide 26-36 renin Rattus norvegicus 103-108 9186867-9 1997 In separate experiments, the inhibitory effect of L-NAME on the activation of renin secretion was abolished when afferent arterioles were treated with nicardipine, an L-type Ca2+ channel blocker, suggesting that the suppression of renin activation during NO inhibition is due to increased Ca2+ entry. NG-Nitroarginine Methyl Ester 50-56 renin Rattus norvegicus 78-83 9186867-9 1997 In separate experiments, the inhibitory effect of L-NAME on the activation of renin secretion was abolished when afferent arterioles were treated with nicardipine, an L-type Ca2+ channel blocker, suggesting that the suppression of renin activation during NO inhibition is due to increased Ca2+ entry. NG-Nitroarginine Methyl Ester 50-56 renin Rattus norvegicus 231-236 9186867-9 1997 In separate experiments, the inhibitory effect of L-NAME on the activation of renin secretion was abolished when afferent arterioles were treated with nicardipine, an L-type Ca2+ channel blocker, suggesting that the suppression of renin activation during NO inhibition is due to increased Ca2+ entry. Nicardipine 151-162 renin Rattus norvegicus 78-83 9186867-9 1997 In separate experiments, the inhibitory effect of L-NAME on the activation of renin secretion was abolished when afferent arterioles were treated with nicardipine, an L-type Ca2+ channel blocker, suggesting that the suppression of renin activation during NO inhibition is due to increased Ca2+ entry. Nicardipine 151-162 renin Rattus norvegicus 231-236 9186867-12 1997 In addition, bosentan coadministered with L-NAME in vivo blunted the inhibitory effect of L-NAME and restored the increases in renin mRNA level, synthesis and secretion. Bosentan 13-21 renin Rattus norvegicus 127-132 9186867-12 1997 In addition, bosentan coadministered with L-NAME in vivo blunted the inhibitory effect of L-NAME and restored the increases in renin mRNA level, synthesis and secretion. NG-Nitroarginine Methyl Ester 42-48 renin Rattus norvegicus 127-132 9136670-2 1997 To this end the renin system in male Sprague Dawley rats was stimulated by unilateral renal artery clipping (0.2 mm clip), by furosemide (60 mg/kg per diem) or isoproterenol (160 microg/kg per diem), and by ingestion of a low-salt diet (0.02%), or was suppressed by setting a contralateral renal artery clip (0.2-mm clip) or by ingestion of a high-salt diet (4%). Isoproterenol 160-173 renin Rattus norvegicus 16-21 9136670-4 1997 Renin gene expression was stimulated four- to fivefold by renal artery clipping and isoproterenol infusion, two- to three-fold by furosemide and a low-salt diet, and about four-fold by losartan. Isoproterenol 84-97 renin Rattus norvegicus 0-5 9136670-4 1997 Renin gene expression was stimulated four- to fivefold by renal artery clipping and isoproterenol infusion, two- to three-fold by furosemide and a low-salt diet, and about four-fold by losartan. Furosemide 130-140 renin Rattus norvegicus 0-5 9136670-4 1997 Renin gene expression was stimulated four- to fivefold by renal artery clipping and isoproterenol infusion, two- to three-fold by furosemide and a low-salt diet, and about four-fold by losartan. Salts 151-155 renin Rattus norvegicus 0-5 9136670-4 1997 Renin gene expression was stimulated four- to fivefold by renal artery clipping and isoproterenol infusion, two- to three-fold by furosemide and a low-salt diet, and about four-fold by losartan. Losartan 185-193 renin Rattus norvegicus 0-5 9136670-5 1997 Additional treatment with losartan potentiated the stimulatory effects of a low-salt diet, of furosemide and of isoproterenol infusion on renin gene expression, whilst there was no significant additional effect of losartan on renin gene expression in clipped kidneys. Losartan 26-34 renin Rattus norvegicus 138-143 9136670-5 1997 Additional treatment with losartan potentiated the stimulatory effects of a low-salt diet, of furosemide and of isoproterenol infusion on renin gene expression, whilst there was no significant additional effect of losartan on renin gene expression in clipped kidneys. Isoproterenol 112-125 renin Rattus norvegicus 138-143 9136670-6 1997 Both contralateral renal artery clipping and a high-salt diet decreased renin mRNA levels to about 50% of the control value. Salts 52-56 renin Rattus norvegicus 72-77 9136670-7 1997 In rts with a unilateral clip, additional losartan treatment caused renin mRNA to increase to about 350% of the control value in the contralateral kidney but to only 100% of the control value in animals on a high-salt diet. Losartan 42-50 renin Rattus norvegicus 68-73 9136670-8 1997 These findings suggest that the enhanced formation of angiotensin II during a low-salt intake, during tubular inhibition of salt reabsorption or during beta-adrenoreceptor activation plays a relevant negative feedback role in the activation of the renin gene. Salts 82-86 renin Rattus norvegicus 248-253 9136670-8 1997 These findings suggest that the enhanced formation of angiotensin II during a low-salt intake, during tubular inhibition of salt reabsorption or during beta-adrenoreceptor activation plays a relevant negative feedback role in the activation of the renin gene. Salts 124-128 renin Rattus norvegicus 248-253 9160791-0 1997 The implication of renin-angiotensin system on renal injury seen in Dahl salt-sensitive rats. Salts 73-77 renin Rattus norvegicus 19-24 9160791-9 1997 Multivariate analysis revealed that activity of the renin-angiotensin system is an independent risk factor to glomerular injury in salt-induced hypertension. Salts 131-135 renin Rattus norvegicus 52-57 9160792-8 1997 The inhibition of renin-angiotensin system by cilazapril showed that Ca extrusion by ATP-driven Ca pump was decreased by salt loading, and that Ca extrusion by Na/Ca exchange was increased by salt loading. Cilazapril 46-56 renin Rattus norvegicus 18-23 9160792-8 1997 The inhibition of renin-angiotensin system by cilazapril showed that Ca extrusion by ATP-driven Ca pump was decreased by salt loading, and that Ca extrusion by Na/Ca exchange was increased by salt loading. Adenosine Triphosphate 85-88 renin Rattus norvegicus 18-23 9160792-8 1997 The inhibition of renin-angiotensin system by cilazapril showed that Ca extrusion by ATP-driven Ca pump was decreased by salt loading, and that Ca extrusion by Na/Ca exchange was increased by salt loading. Salts 121-125 renin Rattus norvegicus 18-23 9176324-1 1997 The neuronal isoform of nitric oxide synthase (nNOS) exists in the renal cortex predominantly in the macula densa, suggesting that nitric oxide (NO) derived from the macula densa plays a role in feedback regulation of renin in response to altered sodium metabolism. Nitric Oxide 24-36 renin Rattus norvegicus 218-223 9160792-8 1997 The inhibition of renin-angiotensin system by cilazapril showed that Ca extrusion by ATP-driven Ca pump was decreased by salt loading, and that Ca extrusion by Na/Ca exchange was increased by salt loading. Salts 192-196 renin Rattus norvegicus 18-23 9176324-2 1997 To determine if nNOS is a critical component in renin stimulation induced by dietary sodium restriction, rats received either normal sodium or a sodium-restricted diet (0.03%) for 7 days and subsequently were or were not treated with the selective inhibitor of nNOS 7-nitroindazole (7-NI) either acutely (50 mg/kg body wt ip) on the final day or chronically (20 mg/kg body wt ip 2 x/day) over the final 5 days. Sodium 85-91 renin Rattus norvegicus 48-53 9176324-5 1997 Both renal venous renin (RR) and renin secretion rate (RSR) were elevated approximately fourfold by sodium restriction [RR = 5.8 +/- 0.8 vs. 20.5 +/- 2.7 ng angiotensin (ANG) I.ml-1.h-1; P < 0.001; RSR = 3.0 +/- 0.9 vs. 13.1 +/- 4.1 ng ANG I.h-1.min-1; P < 0.025]. Sodium 100-106 renin Rattus norvegicus 18-23 9140020-1 1997 This study was designed to determine if the increase in plasma renin activity (PRA) that occurs during water deprivation is mediated by the renal sympathetic nerves or adrenomedullary catecholamine release. Water 103-108 renin Rattus norvegicus 63-68 9176324-8 1997 Although selective NOS inhibition by 7-NI did not affect BP, RBF, or renin in control rats on a normal diet, chronic 7-NI reversed the stimulation of renin induced by dietary sodium restriction. 7-nitroindazole 117-121 renin Rattus norvegicus 150-155 9176324-8 1997 Although selective NOS inhibition by 7-NI did not affect BP, RBF, or renin in control rats on a normal diet, chronic 7-NI reversed the stimulation of renin induced by dietary sodium restriction. Sodium 175-181 renin Rattus norvegicus 150-155 9176324-9 1997 These data suggest that nNOS-derived NO plays an important role in the macula densa during feedback stimulation of renin induced by dietary sodium restriction. Sodium 140-146 renin Rattus norvegicus 115-120 9186844-5 1997 Compared with placebo-treated cirrhotic rats, octreotide caused increased urine sodium excretion (-10 +/- 4% vs. 13 +/- 8% from baseline values, p < 0.05) and systemic vascular resistance (2.6 +/- 0.1 vs. 3.3 +/- 0.3 mmHg.min.100 g.ml-1, p < 0.05); and decreased plasma atrial natriuretic peptide levels (166.7 +/- 24.8 vs. 234.0 +/- 19.2 pg/ ml, p < 0.05), renin activities (2.45 +/- 0.49 vs. 4.36 +/- 0.53 ng.ml-1.h-1, p < 0.01) and aldosterone concentrations (290.2 +/- 40.0 vs. 483.3 +/- 82.6 pg/ml, p < 0.05). Octreotide 46-56 renin Rattus norvegicus 367-372 9128204-13 1997 Brain L-arginine thus appears to exert pressor actions through stimulation of the brain renin-angiotensin system and peripheral SNA. Arginine 6-16 renin Rattus norvegicus 88-93 9128205-9 1997 Captopril treatment increased renin mRNA in both sham operated and UNX rats as compared with untreated controls, but had no significant effect on Ang II receptor density and AT1 receptor mRNA; and no change was observed in either variable as a consequence of UNX. Captopril 0-9 renin Rattus norvegicus 30-35 9170003-0 1997 Sodium intake regulates renin gene expression differently in the hypothalamus and kidney of rats. Sodium 0-6 renin Rattus norvegicus 24-29 9170003-1 1997 OBJECTIVE: To elucidate the different effects of sodium intake on renin messenger RNA (mRNA) in the hypothalamus and the kidney and to investigate the role of hypothalamic renin in sodium-induced hypertension. Sodium 49-55 renin Rattus norvegicus 66-71 9170003-1 1997 OBJECTIVE: To elucidate the different effects of sodium intake on renin messenger RNA (mRNA) in the hypothalamus and the kidney and to investigate the role of hypothalamic renin in sodium-induced hypertension. Sodium 181-187 renin Rattus norvegicus 172-177 9170003-2 1997 DESIGN AND METHODS: We investigated the expression of the renin gene in the hypothalamus and the kidney of rats with altered sodium intake and those administered either deoxycorticosterone acetate (DOCA) or sodium. Sodium 125-131 renin Rattus norvegicus 58-63 9170003-2 1997 DESIGN AND METHODS: We investigated the expression of the renin gene in the hypothalamus and the kidney of rats with altered sodium intake and those administered either deoxycorticosterone acetate (DOCA) or sodium. Desoxycorticosterone Acetate 169-196 renin Rattus norvegicus 58-63 9170003-2 1997 DESIGN AND METHODS: We investigated the expression of the renin gene in the hypothalamus and the kidney of rats with altered sodium intake and those administered either deoxycorticosterone acetate (DOCA) or sodium. Desoxycorticosterone Acetate 198-202 renin Rattus norvegicus 58-63 9170003-2 1997 DESIGN AND METHODS: We investigated the expression of the renin gene in the hypothalamus and the kidney of rats with altered sodium intake and those administered either deoxycorticosterone acetate (DOCA) or sodium. Sodium 207-213 renin Rattus norvegicus 58-63 9170003-7 1997 RESULTS: A high sodium intake for 10 days increased the renin mRNA in the hypothalamus; the hypothalamic renin mRNA had not been suppressed after 8 weeks of a high sodium intake despite the lowering in renal renin mRNA. Sodium 16-22 renin Rattus norvegicus 56-61 9170003-7 1997 RESULTS: A high sodium intake for 10 days increased the renin mRNA in the hypothalamus; the hypothalamic renin mRNA had not been suppressed after 8 weeks of a high sodium intake despite the lowering in renal renin mRNA. Sodium 16-22 renin Rattus norvegicus 105-110 9170003-7 1997 RESULTS: A high sodium intake for 10 days increased the renin mRNA in the hypothalamus; the hypothalamic renin mRNA had not been suppressed after 8 weeks of a high sodium intake despite the lowering in renal renin mRNA. Sodium 16-22 renin Rattus norvegicus 105-110 9170003-10 1997 The constant expression of the renin gene in the hypothalamus during a chronic high sodium load might be related at least in part to the mechanism of the activated brain renin-angiotensin system in sodium-induced hypertension. Sodium 84-90 renin Rattus norvegicus 31-36 9170003-10 1997 The constant expression of the renin gene in the hypothalamus during a chronic high sodium load might be related at least in part to the mechanism of the activated brain renin-angiotensin system in sodium-induced hypertension. Sodium 84-90 renin Rattus norvegicus 170-175 9170003-10 1997 The constant expression of the renin gene in the hypothalamus during a chronic high sodium load might be related at least in part to the mechanism of the activated brain renin-angiotensin system in sodium-induced hypertension. Sodium 198-204 renin Rattus norvegicus 31-36 9170003-10 1997 The constant expression of the renin gene in the hypothalamus during a chronic high sodium load might be related at least in part to the mechanism of the activated brain renin-angiotensin system in sodium-induced hypertension. Sodium 198-204 renin Rattus norvegicus 170-175 9195301-8 1997 These results suggest that nitric oxide interacts with the renin angiotensin system to control the vascular tension and systemic arterial circulation in RHR. Nitric Oxide 27-39 renin Rattus norvegicus 59-64 9140020-1 1997 This study was designed to determine if the increase in plasma renin activity (PRA) that occurs during water deprivation is mediated by the renal sympathetic nerves or adrenomedullary catecholamine release. Catecholamines 184-197 renin Rattus norvegicus 63-68 9140020-3 1997 In intact or sham-operated rats, 48 h of water deprivation resulted in at least a threefold increase in PRA and plasma renin concentration (PRC) but no significant change in plasma norepinephrine or epinephrine concentration. Water 41-46 renin Rattus norvegicus 119-124 9140020-4 1997 Renal denervation decreased basal PRA, reduced the magnitude of the dehydration-induced PRA increase by 33%, and abolished the renin-suppressing effect of l-propranolol infusion in water-deprived rats. l-propranolol 155-168 renin Rattus norvegicus 127-132 9140020-4 1997 Renal denervation decreased basal PRA, reduced the magnitude of the dehydration-induced PRA increase by 33%, and abolished the renin-suppressing effect of l-propranolol infusion in water-deprived rats. Water 181-186 renin Rattus norvegicus 127-132 9315231-0 1997 Involvement of renin-angiotensin system in hypertensive effect of cadmium in rats. Cadmium 66-73 renin Rattus norvegicus 15-20 9251770-0 1997 Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol. Carbachol 131-140 renin Rattus norvegicus 37-42 9095084-7 1997 Fenoldopam, a D1-like receptor agonist, also caused a concentration-dependent increase in cAMP production and renin secretion that was blocked by the selective D1-like receptor antagonist SCH23390 (n = 4-13 per group). Fenoldopam 0-10 renin Rattus norvegicus 110-115 9095084-7 1997 Fenoldopam, a D1-like receptor agonist, also caused a concentration-dependent increase in cAMP production and renin secretion that was blocked by the selective D1-like receptor antagonist SCH23390 (n = 4-13 per group). SCH 23390 188-196 renin Rattus norvegicus 110-115 9315231-1 1997 Role of renin-angiotensin system in hypertension induced by cadmium chloride (CdCl2) in rats has been investigated. Cadmium Chloride 60-76 renin Rattus norvegicus 8-13 9315231-16 1997 The results are discussed in light of a differential involvement of central vs peripheral renin-angiotensin system in the hypertensive effect of Cd. Cadmium 145-147 renin Rattus norvegicus 90-95 9049174-10 1997 At the same time plasma renin activities were markedly increased in rats fed a low-salt diet and substantially suppressed in rats fed a high-salt diet, suggesting the efficacy of the salt diet. Salts 83-87 renin Rattus norvegicus 24-29 9049174-10 1997 At the same time plasma renin activities were markedly increased in rats fed a low-salt diet and substantially suppressed in rats fed a high-salt diet, suggesting the efficacy of the salt diet. Salts 141-145 renin Rattus norvegicus 24-29 9049174-10 1997 At the same time plasma renin activities were markedly increased in rats fed a low-salt diet and substantially suppressed in rats fed a high-salt diet, suggesting the efficacy of the salt diet. Salts 141-145 renin Rattus norvegicus 24-29 9040448-1 1997 To evaluate the role of the renin gene in the development of hypertension in Dahl salt-sensitive rats (SS/Jr/Hsd), we derived a congenic strain of rats homozygous for the salt-resistant renin allele (S/renrr) and compared them with a control strain homozygous for the salt-sensitive renin allele (S/ren(ss). Salts 171-175 renin Rattus norvegicus 186-191 9032091-4 1997 In euglycemic-hyperinsulinemic clamp studies using the same insulin infusion rate (10 pmol x kg(-1) x min(-1), insulin resistance was found in REN animals (mean glucose infusion rate [GIR], REN: 7.5 +/- 1.2; RMA: 12.0 +/- 1.2; normal: 12.7 +/- 1.0 mg x kg(-1) x min(-1); P < 0.008), with higher steady-state insulin levels in REN (554 +/- 63 pmol/l) than in RMA (291 +/- 26) and normal rats (269 +/- 60), P < 0.0001. Glucose 161-168 renin Rattus norvegicus 143-146 9040448-0 1997 Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. Salts 14-18 renin Rattus norvegicus 29-34 9040448-0 1997 Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. dahl salt 67-76 renin Rattus norvegicus 29-34 9024144-14 1997 Increased vascular .O2- may contribute to vascular disease in high renin/angiotensin II states. Superoxides 20-22 renin Rattus norvegicus 67-72 9040448-1 1997 To evaluate the role of the renin gene in the development of hypertension in Dahl salt-sensitive rats (SS/Jr/Hsd), we derived a congenic strain of rats homozygous for the salt-resistant renin allele (S/renrr) and compared them with a control strain homozygous for the salt-sensitive renin allele (S/ren(ss). Salts 171-175 renin Rattus norvegicus 186-191 9040448-1 1997 To evaluate the role of the renin gene in the development of hypertension in Dahl salt-sensitive rats (SS/Jr/Hsd), we derived a congenic strain of rats homozygous for the salt-resistant renin allele (S/renrr) and compared them with a control strain homozygous for the salt-sensitive renin allele (S/ren(ss). Salts 171-175 renin Rattus norvegicus 186-191 9040448-1 1997 To evaluate the role of the renin gene in the development of hypertension in Dahl salt-sensitive rats (SS/Jr/Hsd), we derived a congenic strain of rats homozygous for the salt-resistant renin allele (S/renrr) and compared them with a control strain homozygous for the salt-sensitive renin allele (S/ren(ss). Salts 171-175 renin Rattus norvegicus 186-191 9040448-4 1997 Plasma renin activity of S/renrr rats was significantly higher than that of S/ren(ss) rats fed a very low salt diet (5.7 +/- 2.0 versus 1.8 +/- 0.3) ng angiotensin l/mL per hour), a low salt diet (4.4 +/- 1.0 versus 1.1 +/- 0.3), or a high salt diet (1.5 +/- 0.2 versus 0.9 +/- 0.1). Salts 106-110 renin Rattus norvegicus 7-12 9040448-4 1997 Plasma renin activity of S/renrr rats was significantly higher than that of S/ren(ss) rats fed a very low salt diet (5.7 +/- 2.0 versus 1.8 +/- 0.3) ng angiotensin l/mL per hour), a low salt diet (4.4 +/- 1.0 versus 1.1 +/- 0.3), or a high salt diet (1.5 +/- 0.2 versus 0.9 +/- 0.1). Salts 186-190 renin Rattus norvegicus 7-12 9040448-4 1997 Plasma renin activity of S/renrr rats was significantly higher than that of S/ren(ss) rats fed a very low salt diet (5.7 +/- 2.0 versus 1.8 +/- 0.3) ng angiotensin l/mL per hour), a low salt diet (4.4 +/- 1.0 versus 1.1 +/- 0.3), or a high salt diet (1.5 +/- 0.2 versus 0.9 +/- 0.1). Salts 186-190 renin Rattus norvegicus 7-12 9040448-9 1997 These results indicate that transfer of a salt-resistant renin allele to SS/Jr/Hsd rats raises plasma renin activity and augments the severity of hypertension and renal disease. Salts 42-46 renin Rattus norvegicus 57-62 9040448-9 1997 These results indicate that transfer of a salt-resistant renin allele to SS/Jr/Hsd rats raises plasma renin activity and augments the severity of hypertension and renal disease. Salts 42-46 renin Rattus norvegicus 102-107 9140837-4 1997 Two weeks of captopril treatment significantly reduced blood pressure (BP) and relative heart weight, and increased plasma renin activity. Captopril 13-22 renin Rattus norvegicus 123-128 9048337-5 1997 Plasma renin activity was significantly elevated by losartan treatment, low salt intake, or a combination of the two, compared with the plasma renin activity of the controls. Losartan 52-60 renin Rattus norvegicus 7-12 9048337-5 1997 Plasma renin activity was significantly elevated by losartan treatment, low salt intake, or a combination of the two, compared with the plasma renin activity of the controls. Salts 76-80 renin Rattus norvegicus 7-12 9244372-7 1997 Pioglitazone treatment also significantly reduced the urinary excretion of catecholamines and plasma renin activity, both of which were significantly greater in sucrose-fed SHR than in control SHR. Pioglitazone 0-12 renin Rattus norvegicus 101-106 9192903-0 1997 Enalapril and pressure-diuresis in hypertensive rats transgenic for mouse renin gene. Enalapril 0-9 renin Rattus norvegicus 74-79 9192903-3 1997 Dysfunction of the renin-angiotensin and nitric oxide systems may cause in this abnormality. Nitric Oxide 41-53 renin Rattus norvegicus 19-24 9244372-7 1997 Pioglitazone treatment also significantly reduced the urinary excretion of catecholamines and plasma renin activity, both of which were significantly greater in sucrose-fed SHR than in control SHR. Sucrose 161-168 renin Rattus norvegicus 101-106 8986455-12 1996 TCV-116 and HCTZ each caused a significant increase in plasma renin concentration (PRC), and prazosin caused a slight elevation. candesartan cilexetil 0-7 renin Rattus norvegicus 62-67 8952611-8 1996 For example, using decoy oligonucleotides, we have "turned on" renin gene expression in the rat liver, in which it is usually not expressed, resulting in increased hepatic and plasma renin levels. Oligonucleotides 25-41 renin Rattus norvegicus 63-68 8952611-8 1996 For example, using decoy oligonucleotides, we have "turned on" renin gene expression in the rat liver, in which it is usually not expressed, resulting in increased hepatic and plasma renin levels. Oligonucleotides 25-41 renin Rattus norvegicus 183-188 8958581-9 1996 Chronic losartan treatment markedly augmented the AVP, renin and EPI responses to hemorrhage. Losartan 8-16 renin Rattus norvegicus 55-60 8958582-0 1996 Gene expression of central and peripheral renin-angiotensin system components upon dietary sodium intake in rats. Sodium 91-97 renin Rattus norvegicus 42-47 8958582-1 1996 The effects of dietary sodium intake on the gene expression of the renin-angiotensin system (RAS) were investigated in rat central and peripheral tissues in a single set of experiment. Sodium 23-29 renin Rattus norvegicus 67-72 8958582-3 1996 Plasma and renal renin levels were elevated in rats maintained on the low-sodium diet. Sodium 74-80 renin Rattus norvegicus 17-22 8958582-4 1996 Sodium deprivation enhanced the expression of angiotensinogen, renin, AT1A and AT1B receptor subtypes in the hypothalamus, but suppressed them in the brainstem. Sodium 0-6 renin Rattus norvegicus 63-68 8986455-12 1996 TCV-116 and HCTZ each caused a significant increase in plasma renin concentration (PRC), and prazosin caused a slight elevation. Hydrochlorothiazide 12-16 renin Rattus norvegicus 62-67 8986455-15 1996 These results suggest that antihypertensive drugs that cause compensatory activation of the renin-angiotensin system have more marked antihypertensive activity when given in combination with TCV-116, but that there will is no combined effect on the pulse rate. candesartan cilexetil 191-198 renin Rattus norvegicus 92-97 8945984-5 1996 Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Sodium 8-14 renin Rattus norvegicus 96-101 8961071-5 1996 Perindopril inhibited plasma ACE activity and increased plasma renin, with an associated decrease in plasma angiotensinogen. Perindopril 0-11 renin Rattus norvegicus 63-68 8945954-7 1996 Renin responses to isoprenaline remained blunted (P < 0.01) during losartan infusion in LH rats. Isoproterenol 19-31 renin Rattus norvegicus 0-5 8945954-7 1996 Renin responses to isoprenaline remained blunted (P < 0.01) during losartan infusion in LH rats. Losartan 70-78 renin Rattus norvegicus 0-5 8945984-5 1996 Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Sodium 8-14 renin Rattus norvegicus 151-156 8945984-0 1996 Dietary sodium effects on renin and angiotensinogen gene expression in preweanling WKY and SHR. Sodium 8-14 renin Rattus norvegicus 26-31 8945984-5 1996 Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Sodium 8-14 renin Rattus norvegicus 151-156 8945984-5 1996 Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Sodium 128-134 renin Rattus norvegicus 151-156 8945984-5 1996 Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Sodium 128-134 renin Rattus norvegicus 151-156 8945984-5 1996 Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Sodium 128-134 renin Rattus norvegicus 151-156 8945984-5 1996 Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Sodium 128-134 renin Rattus norvegicus 151-156 8945984-9 1996 These results demonstrate that 1) the peripheral and central renin-angiotensin systems do not have a common ontogenetic pattern of development, 2) they are independently regulated in response to dietary sodium variations, and 3) young WKY and SHR share very similar ontogenetic patterns of angiotensinogen and renin gene expression. Sodium 203-209 renin Rattus norvegicus 61-66 8973755-7 1996 Simultaneous treatment with Losartan reduced the Ang II-induced effects on blood pressure and heart weight, and attenuated the Ang II-induced decrease in plasma renin activity. Losartan 28-36 renin Rattus norvegicus 161-166 8937709-0 1996 Contribution of the renin-angiotensin system to short-term blood pressure variability during blockade of nitric oxide synthesis in the rat. Nitric Oxide 105-117 renin Rattus norvegicus 20-25 8930204-8 1996 Elevated plasma renin activity and aldosterone levels seen in untreated controls were significantly decreased by propranolol (P < .05), and to a considerably greater extent by the same dose of carvedilol (P < .01). Propranolol 113-124 renin Rattus norvegicus 16-21 8969918-1 1996 This study investigated the effects of Methylenedioxymethamphetamine (MDMA) on aldosterone and renin secretion via, (1) acute administration of MDMA to conscious Wistar rats, and (2) superfusion of whole rat adrenal capsules with 1 microM and 10 microM MDMA, in the presence of 5-HT. N-Methyl-3,4-methylenedioxyamphetamine 70-74 renin Rattus norvegicus 95-100 8969918-4 1996 Basal plasma renin activity (PRA) was 6.86 +/- 1.65 ng/ml/hr in the MDMA treated animals increasing to 228.56 +/- 34.1 ng/ml/hr after administration (P < 0.05). N-Methyl-3,4-methylenedioxyamphetamine 68-72 renin Rattus norvegicus 13-18 8969918-7 1996 In conclusion, acute administration of MDMA to conscious rats causes activation of the renin-angiotensin-aldosterone system. N-Methyl-3,4-methylenedioxyamphetamine 39-43 renin Rattus norvegicus 87-92 8901817-7 1996 Basal plasma renin activity was lower in L-NAME than control rats (5.0 +/- 0.3 versus 9.5 +/- 1.3 U, P < .01), and plasma renin activity was markedly attenuated at all comparable levels of renal perfusion pressure. NG-Nitroarginine Methyl Ester 41-47 renin Rattus norvegicus 13-18 8901817-8 1996 Maximal plasma renin activity levels were achieved at perfusion pressures reduced to 65 mm Hg, and plasma renin activity averaged 14 +/- 2 and 34 +/- 7 U (P < .01) in L-NAME hypertensive and control rats, respectively. NG-Nitroarginine Methyl Ester 170-176 renin Rattus norvegicus 106-111 8901817-9 1996 However, infusion of the nitric oxide donor sodium nitroprusside similarly stimulated plasma renin activity levels to 39 +/- 3 and 45 +/- 3 U (P > .05), in the hypertensive and normal control groups, respectively. Nitric Oxide 25-37 renin Rattus norvegicus 93-98 8901817-9 1996 However, infusion of the nitric oxide donor sodium nitroprusside similarly stimulated plasma renin activity levels to 39 +/- 3 and 45 +/- 3 U (P > .05), in the hypertensive and normal control groups, respectively. Nitroprusside 44-64 renin Rattus norvegicus 93-98 8901817-10 1996 Overall, these findings are consistent with the hypothesis that prolonged L-NAME administration attenuates pressure-dependent renin release by inhibiting nitric oxide formation, which may function as a paracrine mechanism inversely linking renal perfusion pressure with the stimulation of renin release. NG-Nitroarginine Methyl Ester 74-80 renin Rattus norvegicus 126-131 8901817-10 1996 Overall, these findings are consistent with the hypothesis that prolonged L-NAME administration attenuates pressure-dependent renin release by inhibiting nitric oxide formation, which may function as a paracrine mechanism inversely linking renal perfusion pressure with the stimulation of renin release. NG-Nitroarginine Methyl Ester 74-80 renin Rattus norvegicus 289-294 8901817-10 1996 Overall, these findings are consistent with the hypothesis that prolonged L-NAME administration attenuates pressure-dependent renin release by inhibiting nitric oxide formation, which may function as a paracrine mechanism inversely linking renal perfusion pressure with the stimulation of renin release. Nitric Oxide 154-166 renin Rattus norvegicus 126-131 8901817-10 1996 Overall, these findings are consistent with the hypothesis that prolonged L-NAME administration attenuates pressure-dependent renin release by inhibiting nitric oxide formation, which may function as a paracrine mechanism inversely linking renal perfusion pressure with the stimulation of renin release. Nitric Oxide 154-166 renin Rattus norvegicus 289-294 8930204-8 1996 Elevated plasma renin activity and aldosterone levels seen in untreated controls were significantly decreased by propranolol (P < .05), and to a considerably greater extent by the same dose of carvedilol (P < .01). Carvedilol 196-206 renin Rattus norvegicus 16-21 8884939-10 1996 The results show that the antagonism of the renin-angiotensin system inhibits the 1.5% NaCl intake induced by water deprivation. Sodium Chloride 87-91 renin Rattus norvegicus 44-49 9863143-0 1996 Effect of chronic captopril treatment on circulating and tissue renin-angiotensin system in SHR rats. Captopril 18-27 renin Rattus norvegicus 64-69 9863143-8 1996 Renal renin mRNA level was low in SHR and WKY rats, but it was increased by captopril treatment. Captopril 76-85 renin Rattus norvegicus 6-11 8904650-0 1996 Effect of amlodipine on renin secretion and renin gene expression in rats. Amlodipine 10-20 renin Rattus norvegicus 24-29 8904650-7 1996 However, at a concentration of 15 or 45 mg kg-1, amlodipine, significantly increased not only plasma renin activity by about 250% and 300%, but also renin mRNA levels by about 100% and 500%. Amlodipine 49-59 renin Rattus norvegicus 101-106 8904650-7 1996 However, at a concentration of 15 or 45 mg kg-1, amlodipine, significantly increased not only plasma renin activity by about 250% and 300%, but also renin mRNA levels by about 100% and 500%. Amlodipine 49-59 renin Rattus norvegicus 149-154 8904650-8 1996 The action of amlodipine on all these parameters was maximal after 24 h. Treatment with amlodipine in a concentration of 15 mg kg-1 also increased renin immunoreactive areas in the kidney cortex by retrograde recruitment of renin expressing cells in the afferent arterioles. Amlodipine 14-24 renin Rattus norvegicus 147-152 8904650-8 1996 The action of amlodipine on all these parameters was maximal after 24 h. Treatment with amlodipine in a concentration of 15 mg kg-1 also increased renin immunoreactive areas in the kidney cortex by retrograde recruitment of renin expressing cells in the afferent arterioles. Amlodipine 14-24 renin Rattus norvegicus 224-229 8904650-8 1996 The action of amlodipine on all these parameters was maximal after 24 h. Treatment with amlodipine in a concentration of 15 mg kg-1 also increased renin immunoreactive areas in the kidney cortex by retrograde recruitment of renin expressing cells in the afferent arterioles. Amlodipine 88-98 renin Rattus norvegicus 147-152 8904650-8 1996 The action of amlodipine on all these parameters was maximal after 24 h. Treatment with amlodipine in a concentration of 15 mg kg-1 also increased renin immunoreactive areas in the kidney cortex by retrograde recruitment of renin expressing cells in the afferent arterioles. Amlodipine 88-98 renin Rattus norvegicus 224-229 8904650-11 1996 Amlodipine at a concentration of 15 mg kg-1 markedly attenuated the increase of blood pressure in 2kidney-1 clip rats, produced an almost additive effect on plasma renin activity and showed a tendency to increase renin m-RNA levels in the clipped kidneys. Amlodipine 0-10 renin Rattus norvegicus 164-169 8904650-11 1996 Amlodipine at a concentration of 15 mg kg-1 markedly attenuated the increase of blood pressure in 2kidney-1 clip rats, produced an almost additive effect on plasma renin activity and showed a tendency to increase renin m-RNA levels in the clipped kidneys. Amlodipine 0-10 renin Rattus norvegicus 213-218 8904650-12 1996 Renin m-RNA levels in the contralateral kidney were also significantly suppressed in the animals receiving additional treatment with amlodipine. Amlodipine 133-143 renin Rattus norvegicus 0-5 8904650-14 1996 These findings suggest that inhibition of calcium channels by amlodipine stimulates renin secretion and renin gene expression in vivo. Amlodipine 62-72 renin Rattus norvegicus 84-89 8904650-14 1996 These findings suggest that inhibition of calcium channels by amlodipine stimulates renin secretion and renin gene expression in vivo. Amlodipine 62-72 renin Rattus norvegicus 104-109 8915971-9 1996 Lisinopril increased rat renin and angiotensinogen gene expression both in SDH and TGR, but it did not influence mouse renin gene expression in TGR. Lisinopril 0-10 renin Rattus norvegicus 25-50 8915971-9 1996 Lisinopril increased rat renin and angiotensinogen gene expression both in SDH and TGR, but it did not influence mouse renin gene expression in TGR. Lisinopril 0-10 renin Rattus norvegicus 25-30 8986915-1 1996 OBJECTIVES: To determine the possible relationship between the degree of dietary sodium intake and the development of renal failure during blockade of the renin-angiotensin system. Sodium 81-87 renin Rattus norvegicus 155-160 8794824-4 1996 Plasma renin concentration and renal renin, renal and hepatic angiotensinogen, and hepatic AT1 receptor mRNA levels were all inversely related to salt intake; in contrast, renal AT1 receptor mRNA levels were significantly lower in rats fed low salt, a difference that was exclusively due to a decrease in the AT1A subtype. Salts 146-150 renin Rattus norvegicus 7-12 8794824-6 1996 Similarly, inhibition of Ang II generation with captopril increased plasma renin concentration and renal renin mRNA levels without altering renal or hepatic angiotensinogen mRNA or renal AT1 receptor mRNA levels. Captopril 48-57 renin Rattus norvegicus 75-80 8794824-6 1996 Similarly, inhibition of Ang II generation with captopril increased plasma renin concentration and renal renin mRNA levels without altering renal or hepatic angiotensinogen mRNA or renal AT1 receptor mRNA levels. Captopril 48-57 renin Rattus norvegicus 105-110 8709342-6 1996 RESULTS: In the acute phase of 2K-1C hypertensive rats whose R-A system was enhanced, captopril treatment further enhanced plasma renin activity and plasma angiotensin I and suppressed plasma angiotensin II while reducing blood pressure. Captopril 86-95 renin Rattus norvegicus 130-135 8878107-4 1996 NOR and PHE induced a stronger inhibition on the 3% NaCl intake induced by renin than on the intake induced by deoxycorticosterone (DOC), and CLO did the opposite. Norepinephrine 0-3 renin Rattus norvegicus 75-80 8878107-4 1996 NOR and PHE induced a stronger inhibition on the 3% NaCl intake induced by renin than on the intake induced by deoxycorticosterone (DOC), and CLO did the opposite. Phenylephrine 8-11 renin Rattus norvegicus 75-80 8878107-4 1996 NOR and PHE induced a stronger inhibition on the 3% NaCl intake induced by renin than on the intake induced by deoxycorticosterone (DOC), and CLO did the opposite. Sodium Chloride 52-56 renin Rattus norvegicus 75-80 8856488-2 1996 The purpose of our study was to test the hypothesis that the adenosine receptor antagonist caffeine increases renin release in part by disabling the central nervous system (CNS) adenosine brake on renin release. Adenosine 61-70 renin Rattus norvegicus 197-202 8949370-0 1996 [Contribution of the renin-angiotensin system to the variability of blood pressure in hypertensive rat after blockade of nitric oxide synthesis]. Nitric Oxide 121-133 renin Rattus norvegicus 21-26 8707380-9 1996 The blood pressure-lowering effect of angiotensin I-converting enzyme inhibition suggests a role for the renin-angiotensin system in the malignant form of hypertension that develops in SHR treated with L-NAME. NG-Nitroarginine Methyl Ester 202-208 renin Rattus norvegicus 105-110 8698857-1 1996 cGMP-based regulatory systems are vital for counteracting the renin-angiotensin system (RAS) which promotes volume expansion and high blood pressure. Cyclic GMP 0-4 renin Rattus norvegicus 62-67 8698857-2 1996 Natriuretic peptides and nitric oxide acting through their second messenger cGMP normally increase natriuresis and diuresis, and regulate renin release; however, the severe pathological state of cardiac heart failure is characterized by elevated levels of atrial natriuretic peptide that are no longer able to effectively oppose exaggerated RAS effects. Nitric Oxide 25-37 renin Rattus norvegicus 138-143 8698857-2 1996 Natriuretic peptides and nitric oxide acting through their second messenger cGMP normally increase natriuresis and diuresis, and regulate renin release; however, the severe pathological state of cardiac heart failure is characterized by elevated levels of atrial natriuretic peptide that are no longer able to effectively oppose exaggerated RAS effects. Cyclic GMP 76-80 renin Rattus norvegicus 138-143 8698857-6 1996 An activator of renin gene expression, the angiotensin II type I receptor inhibitor, losartan, increased cGK II mRNA and protein three to fourfold in JG cells. Losartan 85-93 renin Rattus norvegicus 16-21 8856488-13 1996 In the second protocol, hydralazine (1 and 10 mg/kg, administered intraperitoneally) significantly enhanced both the renal secretion of renin and the renal spillover of norepinephrine (NE), thus confirming that hydralazine can increase renin release by unloading arterial baroreceptors and increasing sympathetic tone to the kidneys. Hydralazine 24-35 renin Rattus norvegicus 136-141 8856488-13 1996 In the second protocol, hydralazine (1 and 10 mg/kg, administered intraperitoneally) significantly enhanced both the renal secretion of renin and the renal spillover of norepinephrine (NE), thus confirming that hydralazine can increase renin release by unloading arterial baroreceptors and increasing sympathetic tone to the kidneys. Hydralazine 24-35 renin Rattus norvegicus 236-241 8856488-13 1996 In the second protocol, hydralazine (1 and 10 mg/kg, administered intraperitoneally) significantly enhanced both the renal secretion of renin and the renal spillover of norepinephrine (NE), thus confirming that hydralazine can increase renin release by unloading arterial baroreceptors and increasing sympathetic tone to the kidneys. Hydralazine 211-222 renin Rattus norvegicus 136-141 8856488-15 1996 caffeine (10 micrograms/kg/min) on hydralazine-induced (1 and 10 mg/kg, administered intraperitoneally) changes in renal secretion of renin and renal NE spillover were investigated. Caffeine 0-8 renin Rattus norvegicus 134-139 8856488-15 1996 caffeine (10 micrograms/kg/min) on hydralazine-induced (1 and 10 mg/kg, administered intraperitoneally) changes in renal secretion of renin and renal NE spillover were investigated. Hydralazine 35-46 renin Rattus norvegicus 134-139 8856488-19 1996 caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively). Caffeine 0-8 renin Rattus norvegicus 65-70 8856488-19 1996 caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively). Caffeine 0-8 renin Rattus norvegicus 186-191 8856488-19 1996 caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively). Caffeine 0-8 renin Rattus norvegicus 186-191 8856488-19 1996 caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively). Hydralazine 107-118 renin Rattus norvegicus 65-70 8856488-19 1996 caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively). Hydralazine 132-143 renin Rattus norvegicus 65-70 8856488-19 1996 caffeine significantly (p = 0.03) enhanced the increase in renal renin secretion induced by 1 and 10 mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively; for 10 mg/kg hydralazine, delta 227.8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively). Hydralazine 132-143 renin Rattus norvegicus 65-70 8856488-20 1996 The enhanced renin-secretion response to hydralazine in caffeine-treated rats was accompanied by augmented hydralazine-induced increase in renal NE spillover (p = 0.035). Hydralazine 41-52 renin Rattus norvegicus 13-18 8856488-20 1996 The enhanced renin-secretion response to hydralazine in caffeine-treated rats was accompanied by augmented hydralazine-induced increase in renal NE spillover (p = 0.035). Caffeine 56-64 renin Rattus norvegicus 13-18 8856488-20 1996 The enhanced renin-secretion response to hydralazine in caffeine-treated rats was accompanied by augmented hydralazine-induced increase in renal NE spillover (p = 0.035). Hydralazine 107-118 renin Rattus norvegicus 13-18 8856488-21 1996 These data strongly support the hypothesis of a CNS adenosine brake on renin release that is disabled by caffeine. Adenosine 52-61 renin Rattus norvegicus 71-76 8856488-21 1996 These data strongly support the hypothesis of a CNS adenosine brake on renin release that is disabled by caffeine. Caffeine 105-113 renin Rattus norvegicus 71-76 8864301-5 1996 The relative intakes of water and NaCl were comparable at a low dose of renin, but intake of water exceeded that of NaCl after higher doses. Sodium Chloride 34-38 renin Rattus norvegicus 72-77 8856488-0 1996 Central effects of caffeine on renal renin secretion and norepinephrine spillover. Caffeine 19-27 renin Rattus norvegicus 37-42 8856488-1 1996 Endogenous adenosine in the brain may inhibit central sympathetic tone and thereby restrain renin release, a mechanism that may be particularly important when sympathetic activity is enhanced. Adenosine 11-20 renin Rattus norvegicus 92-97 8856488-2 1996 The purpose of our study was to test the hypothesis that the adenosine receptor antagonist caffeine increases renin release in part by disabling the central nervous system (CNS) adenosine brake on renin release. Caffeine 91-99 renin Rattus norvegicus 110-115 8856488-2 1996 The purpose of our study was to test the hypothesis that the adenosine receptor antagonist caffeine increases renin release in part by disabling the central nervous system (CNS) adenosine brake on renin release. Caffeine 91-99 renin Rattus norvegicus 197-202 8856488-2 1996 The purpose of our study was to test the hypothesis that the adenosine receptor antagonist caffeine increases renin release in part by disabling the central nervous system (CNS) adenosine brake on renin release. Adenosine 61-70 renin Rattus norvegicus 110-115 8760052-6 1996 On the other hand, all four known inhibitors specific for myosin light chain kinase (MLCK), with different chemical structures and mechanisms of inhibition (ML-9, ML-7, KT-5926 and wortmannin), almost completely protected renin secretion against the inhibition by Ca2+. Wortmannin 181-191 renin Rattus norvegicus 222-227 8797148-1 1996 Blockade of the renin-angiotensin system (RAS) prevents the increase in blood pressure (BP) induced by chronic administration of NG-nitro L-arginine methyl ester (L-NAME) in rats. NG-Nitroarginine Methyl Ester 129-161 renin Rattus norvegicus 16-21 8760053-15 1996 Incubation in hypotonic KCl medium, isosmotic NH4Cl or CH3COONH4 medium, or isosmotic KCl or CH3COOK medium plus nigericin in the absence of Ca2+ all produced a significant increase in renin secretion 2- to 14-fold (P < 0.001). ch3cook medium 93-107 renin Rattus norvegicus 185-190 8760053-15 1996 Incubation in hypotonic KCl medium, isosmotic NH4Cl or CH3COONH4 medium, or isosmotic KCl or CH3COOK medium plus nigericin in the absence of Ca2+ all produced a significant increase in renin secretion 2- to 14-fold (P < 0.001). Nigericin 113-122 renin Rattus norvegicus 185-190 8806978-8 1996 These results strongly suggest that the renin-angiotensin system modulates the insulin resistance, hypertension, and cardiac hypertrophy in fructose-treated rats. Fructose 140-148 renin Rattus norvegicus 40-45 8797148-1 1996 Blockade of the renin-angiotensin system (RAS) prevents the increase in blood pressure (BP) induced by chronic administration of NG-nitro L-arginine methyl ester (L-NAME) in rats. NG-Nitroarginine Methyl Ester 163-169 renin Rattus norvegicus 16-21 8765998-2 1996 Stimulation of the renin system was achieved by unilateral renal artery clipping (2-kidney/1-clip rats), treatment with the angiotensin II (ANG II) antagonist losartan (40 mg/kg), application of furosemide (12 mg x kg-1 x day-1) and a low-sodium diet (0.02% w/w Na+), which increased renin mRNA levels to 464%, 495%, 309% and 219% of those of control animals, respectively. Losartan 159-167 renin Rattus norvegicus 19-24 8765998-2 1996 Stimulation of the renin system was achieved by unilateral renal artery clipping (2-kidney/1-clip rats), treatment with the angiotensin II (ANG II) antagonist losartan (40 mg/kg), application of furosemide (12 mg x kg-1 x day-1) and a low-sodium diet (0.02% w/w Na+), which increased renin mRNA levels to 464%, 495%, 309% and 219% of those of control animals, respectively. Furosemide 195-205 renin Rattus norvegicus 19-24 8765998-2 1996 Stimulation of the renin system was achieved by unilateral renal artery clipping (2-kidney/1-clip rats), treatment with the angiotensin II (ANG II) antagonist losartan (40 mg/kg), application of furosemide (12 mg x kg-1 x day-1) and a low-sodium diet (0.02% w/w Na+), which increased renin mRNA levels to 464%, 495%, 309% and 219% of those of control animals, respectively. Sodium 239-245 renin Rattus norvegicus 19-24 8765998-8 1996 Given a stimulatory role of endothelium-derived relaxing factor (EDRF)/NO on the renin system our findings may provide the first evidence that increases of renal levels of b-NOS mRNA and, as a consequence, of renal EDRF/NO formation could be important mediators of the well-known effect of salt intake and hypoperfusion on the renin system. Salts 290-294 renin Rattus norvegicus 81-86 8764322-0 1996 Coordinate regulation of renal expression of nitric oxide synthase, renin, and angiotensinogen mRNA by dietary salt. Salts 111-115 renin Rattus norvegicus 68-73 8764322-12 1996 These results suggest that ncNOS expression in macula densa cells is inversely regulated by salt intake, thus following the known response of the renin-angiotensin system to changes in salt balance. Salts 185-189 renin Rattus norvegicus 146-151 8743530-1 1996 Endothelins 1, 2, and 3 did not affect basal renin secretion, but selectively inhibited to a similar extent both cAMP-stimulated renin secretion and renin gene expression in isolated renal juxtaglomerular cells. Cyclic AMP 113-117 renin Rattus norvegicus 129-134 8856135-1 1996 We measured the changes produced in renin and the peptide components of the circulating renin-angiotensin system by acute volume expansion alone or associated with salt load in rats. Salts 164-168 renin Rattus norvegicus 88-93 8743530-1 1996 Endothelins 1, 2, and 3 did not affect basal renin secretion, but selectively inhibited to a similar extent both cAMP-stimulated renin secretion and renin gene expression in isolated renal juxtaglomerular cells. Cyclic AMP 113-117 renin Rattus norvegicus 129-134 8612527-0 1996 Tonic inhibition of renin secretion by the 12 lipoxygenase pathway: augmentation by high salt intake. Salts 89-93 renin Rattus norvegicus 20-25 8743530-2 1996 In isolated perfused rat kidneys and after cAMP-stimulated renin secretion using isoproterenol, endothelins inhibited basal renin secretion at a perfusion pressure of 80 mm Hg. Cyclic AMP 43-47 renin Rattus norvegicus 59-64 8662293-0 1996 Blockade of nitric oxide formation inhibits the stimulation of the renin system by a low salt intake. Nitric Oxide 12-24 renin Rattus norvegicus 67-72 8662293-0 1996 Blockade of nitric oxide formation inhibits the stimulation of the renin system by a low salt intake. Salts 89-93 renin Rattus norvegicus 67-72 8662293-1 1996 This study aimed to investigate the possible involvement of endothelial autacoids such as nitric oxide or prostaglandins in the well-known stimulatory effect of a low salt intake on renin secretion and renin gene expression in the kidney. Nitric Oxide 90-102 renin Rattus norvegicus 182-207 8662293-1 1996 This study aimed to investigate the possible involvement of endothelial autacoids such as nitric oxide or prostaglandins in the well-known stimulatory effect of a low salt intake on renin secretion and renin gene expression in the kidney. Prostaglandins 106-120 renin Rattus norvegicus 182-207 8662293-1 1996 This study aimed to investigate the possible involvement of endothelial autacoids such as nitric oxide or prostaglandins in the well-known stimulatory effect of a low salt intake on renin secretion and renin gene expression in the kidney. Salts 167-171 renin Rattus norvegicus 182-207 8662293-4 1996 In animals fed a normal salt diet, L-NAME decreased PRA from 6.5 to 4.9 ng angiotensin I x h(-1) x ml(-1) and decreased renin mRNA levels by about 15%. NG-Nitroarginine Methyl Ester 35-41 renin Rattus norvegicus 120-125 8662293-8 1996 In animals treated with L-NAME, PRA increased to only 7.2 ng ANGI x h(-1) x ml(-1) and renin mRNA increased by 20%. NG-Nitroarginine Methyl Ester 24-30 renin Rattus norvegicus 87-92 8662293-9 1996 These findings indicate that inhibition of nitric oxide formation but not of prostaglandin formation substantially attenuates the stimulatory effect of a low salt intake on the renin system, suggesting that nitric oxide is required for this process. Nitric Oxide 43-55 renin Rattus norvegicus 177-182 8662293-9 1996 These findings indicate that inhibition of nitric oxide formation but not of prostaglandin formation substantially attenuates the stimulatory effect of a low salt intake on the renin system, suggesting that nitric oxide is required for this process. Salts 158-162 renin Rattus norvegicus 177-182 8662293-9 1996 These findings indicate that inhibition of nitric oxide formation but not of prostaglandin formation substantially attenuates the stimulatory effect of a low salt intake on the renin system, suggesting that nitric oxide is required for this process. Nitric Oxide 207-219 renin Rattus norvegicus 177-182 8928911-1 1996 A role for the renal renin-angiotensin system in the direct stimulation of salt appetite in the rat remains controversial because attempts to elicit the behavior by intravenous administration of angiotensin II (ANG II) have been unconvincing. Salts 75-79 renin Rattus norvegicus 21-26 8612527-13 1996 Thus, the LO pathway exerts a tonic inhibitory effect on renin release, which appears particularly important for renin suppression during high salt intake. Salts 143-147 renin Rattus norvegicus 113-118 8807637-4 1996 In SD zona glomerulosa (ZG), renin and its prosequence localised to small steroid cells while in homozygous (receiving lisinopril) and heterozygous (untreated) TG, steroid cells labelled in all cortical zones. Steroids 74-81 renin Rattus norvegicus 29-34 8842500-3 1996 For this purpose, the influence of the renin angiotensin system on the effects of mibefradil (30 mg/kg po) and cilazapril (10 mg/kg po) on neointima formation after carotid injury were evaluated in normotensive rats (normal renin angiotensin system) and DOCA hypertensive rats (suppressed renin angiotensin system). Mibefradil 82-92 renin Rattus norvegicus 39-44 8612527-13 1996 Thus, the LO pathway exerts a tonic inhibitory effect on renin release, which appears particularly important for renin suppression during high salt intake. Salts 143-147 renin Rattus norvegicus 57-62 8612527-7 1996 Further, esculetin (10(-6)M) increased renin release in renal slices from 150 +/- 10 to 310 +/- 20 ng/ml.h (P < 0.05) and this rise was entirely blocked in the presence of 12HETE (10(-7)M; 130 +/- 40 ng/ml.h). esculetin 9-18 renin Rattus norvegicus 39-44 8612527-11 1996 The finding that LO blockers are potent stimulators of PRC in vivo suggests the existence of a physiological tonic inhibition of renin secretion by LO products that is operative under a wide range of salt intake. Salts 200-204 renin Rattus norvegicus 129-134 8613277-4 1996 The renin mRNA concentration in the adrenal glands showed a significant correlation with the genotype of the renin gene in the normal salt diet group (P <.0001), whereas this relationship was not observed in the high salt group. Salts 134-138 renin Rattus norvegicus 4-9 8621206-6 1996 NaCl depletion increased prorenin/renin parameters similarly in both strains. Sodium Chloride 0-4 renin Rattus norvegicus 28-33 8621206-8 1996 Between low and high salt diets in Dahl S rats, plasma renin increased 20-fold, plasma total renin (renin plus prorenin) and renal renin mRNA both increased threefold, and plasma prorenin increased twofold. Salts 21-25 renin Rattus norvegicus 55-60 8621206-8 1996 Between low and high salt diets in Dahl S rats, plasma renin increased 20-fold, plasma total renin (renin plus prorenin) and renal renin mRNA both increased threefold, and plasma prorenin increased twofold. Salts 21-25 renin Rattus norvegicus 93-98 8621206-8 1996 Between low and high salt diets in Dahl S rats, plasma renin increased 20-fold, plasma total renin (renin plus prorenin) and renal renin mRNA both increased threefold, and plasma prorenin increased twofold. Salts 21-25 renin Rattus norvegicus 93-98 8621206-8 1996 Between low and high salt diets in Dahl S rats, plasma renin increased 20-fold, plasma total renin (renin plus prorenin) and renal renin mRNA both increased threefold, and plasma prorenin increased twofold. Salts 21-25 renin Rattus norvegicus 93-98 8621206-11 1996 Suppression of plasma renin may delay the salt-induced blood pressure rise in Dahl S rats. Salts 42-46 renin Rattus norvegicus 22-27 8963340-1 1996 Administration of angiotensin-converting enzyme inhibitor captopril inhibited the activity of renin-angiotensin system (RAS), increased leukin-enkephalin level in the hypothalamus and adenohypophysis. Captopril 58-67 renin Rattus norvegicus 94-99 8613277-4 1996 The renin mRNA concentration in the adrenal glands showed a significant correlation with the genotype of the renin gene in the normal salt diet group (P <.0001), whereas this relationship was not observed in the high salt group. Salts 134-138 renin Rattus norvegicus 109-114 8613277-6 1996 The SHR allele of the renin gene was associated with a lower aldosterone concentration. Aldosterone 61-72 renin Rattus norvegicus 22-27 8613277-7 1996 On the other hand, in the high salt diet group, only the genotype of the renin gene showed a significant relationship with plasma aldosterone concentration (P=.0237). Salts 31-35 renin Rattus norvegicus 73-78 8613277-7 1996 On the other hand, in the high salt diet group, only the genotype of the renin gene showed a significant relationship with plasma aldosterone concentration (P=.0237). Aldosterone 130-141 renin Rattus norvegicus 73-78 8613277-8 1996 Again, the SHR allele of the renin gene was associated with a lower aldosterone concentration. Aldosterone 68-79 renin Rattus norvegicus 29-34 8613277-11 1996 Paradoxically, the SHR allele of the renin gene or renin gene locus confers a lower rate of aldosterone synthesis at 25 to 27 weeks of age, the mechanism of which remains to be determined. Aldosterone 92-103 renin Rattus norvegicus 37-42 8819647-17 1996 Activation of serotonin1A (5HT1A) receptors with the anti-anxiety drugs buspirone and ipsapirone reduces the firing rate of serotonergic neurons in the dorsal raphe nucleus in the midbrain and decreases the effect of stress on plasma renin concentrations. Buspirone 72-81 renin Rattus norvegicus 234-239 8613277-11 1996 Paradoxically, the SHR allele of the renin gene or renin gene locus confers a lower rate of aldosterone synthesis at 25 to 27 weeks of age, the mechanism of which remains to be determined. Aldosterone 92-103 renin Rattus norvegicus 51-56 8698444-3 1996 We evaluated renin mRNA expression levels in the ventricles under various pathological conditions and found that renin gene expression was markedly increased in the ventricles of isoproterenol-treated rats. Isoproterenol 179-192 renin Rattus norvegicus 13-18 8698444-3 1996 We evaluated renin mRNA expression levels in the ventricles under various pathological conditions and found that renin gene expression was markedly increased in the ventricles of isoproterenol-treated rats. Isoproterenol 179-192 renin Rattus norvegicus 113-118 8698444-4 1996 Renin mRNA expression levels in the ventricles of rats that had been injected with isoproterenol (150 mg/kg SC) were transiently and markedly increased to 6-, 90-, and 4-fold compared with control expression levels at 24, 72, and 120 hours, respectively, after isoproterenol administration, Immunohistochemical analysis revealed that some of the OX-42-positive macrophage/monocyte cells had a reninlike immunoreactivity. Isoproterenol 83-96 renin Rattus norvegicus 0-5 8698444-4 1996 Renin mRNA expression levels in the ventricles of rats that had been injected with isoproterenol (150 mg/kg SC) were transiently and markedly increased to 6-, 90-, and 4-fold compared with control expression levels at 24, 72, and 120 hours, respectively, after isoproterenol administration, Immunohistochemical analysis revealed that some of the OX-42-positive macrophage/monocyte cells had a reninlike immunoreactivity. Isoproterenol 261-274 renin Rattus norvegicus 0-5 8648902-0 1996 Regulation of renin release is impaired after nitric oxide inhibition. Nitric Oxide 46-58 renin Rattus norvegicus 14-19 8648902-4 1996 Renin secretion was increased in isolated afferent arterioles after in vivo treatment with the diuretic furosemide (+300%) or in vitro treatment with the adenylyl cyclase activator forskolin (+50%), indicating that this vascular preparation responds appropriately to regulators of the renin-angiotensin system. Furosemide 104-114 renin Rattus norvegicus 0-5 8648902-4 1996 Renin secretion was increased in isolated afferent arterioles after in vivo treatment with the diuretic furosemide (+300%) or in vitro treatment with the adenylyl cyclase activator forskolin (+50%), indicating that this vascular preparation responds appropriately to regulators of the renin-angiotensin system. Colforsin 181-190 renin Rattus norvegicus 0-5 8648902-4 1996 Renin secretion was increased in isolated afferent arterioles after in vivo treatment with the diuretic furosemide (+300%) or in vitro treatment with the adenylyl cyclase activator forskolin (+50%), indicating that this vascular preparation responds appropriately to regulators of the renin-angiotensin system. Colforsin 181-190 renin Rattus norvegicus 285-290 8648902-10 1996 In both preparations, SIN-1 reversed the L-NAME effect and re-established the responsiveness of renin release to forskolin and the relationship between renin release and renin content. Colforsin 113-122 renin Rattus norvegicus 96-101 8613199-2 1996 We used human and mouse renin, transgenic human angiotensinogen, and the human renin inhibitor Ro 42-5892 to determine human- and rat-specific plasma angiotensinogen concentrations, renin activity, and renin concentration. remikiren 95-105 renin Rattus norvegicus 79-84 8613199-2 1996 We used human and mouse renin, transgenic human angiotensinogen, and the human renin inhibitor Ro 42-5892 to determine human- and rat-specific plasma angiotensinogen concentrations, renin activity, and renin concentration. remikiren 95-105 renin Rattus norvegicus 79-84 8730920-0 1996 Excretion and metabolism of remikiren, a potent orally active inhibitor of primate renin. remikiren 28-37 renin Rattus norvegicus 83-88 8819647-6 1996 Destruction of cells in the paraventricular hypothalamic nucleus (PVH), either electrolytically or with the cell-selective neurotoxin ibotenic acid, prevents the effect of conditioned fear stress, but not of immobilization, on plasma renin concentration. Ibotenic Acid 134-147 renin Rattus norvegicus 234-239 8819647-8 1996 Ibotenic acid-induced lesions in the central amygdaloid nucleus inhibit conditioned fear stress-induced increases in plasma renin concentrations, but do not reduce the renin response to immobilization. Ibotenic Acid 0-13 renin Rattus norvegicus 124-129 8819647-17 1996 Activation of serotonin1A (5HT1A) receptors with the anti-anxiety drugs buspirone and ipsapirone reduces the firing rate of serotonergic neurons in the dorsal raphe nucleus in the midbrain and decreases the effect of stress on plasma renin concentrations. ipsapirone 86-96 renin Rattus norvegicus 234-239 9138750-1 1996 Intracerebroventricular (IVT) administration of renin (R) to conscious male hydrated rats induces an increase in sodium excretion. Sodium 113-119 renin Rattus norvegicus 48-53 8653595-5 1996 Renin activation was not inhibited by serine protease inhibitors, such as phenylmethyl sulfonylfluoride, aprotinin, soybean trypsin inhibitor and N-tosyl-L-phenylalanine chloromethyl ketone or by the cystein protease inhibitors N-ethylmaleimide and leupeptin. Tosylphenylalanyl Chloromethyl Ketone 146-189 renin Rattus norvegicus 0-5 8653595-5 1996 Renin activation was not inhibited by serine protease inhibitors, such as phenylmethyl sulfonylfluoride, aprotinin, soybean trypsin inhibitor and N-tosyl-L-phenylalanine chloromethyl ketone or by the cystein protease inhibitors N-ethylmaleimide and leupeptin. Ethylmaleimide 228-244 renin Rattus norvegicus 0-5 8653595-5 1996 Renin activation was not inhibited by serine protease inhibitors, such as phenylmethyl sulfonylfluoride, aprotinin, soybean trypsin inhibitor and N-tosyl-L-phenylalanine chloromethyl ketone or by the cystein protease inhibitors N-ethylmaleimide and leupeptin. leupeptin 249-258 renin Rattus norvegicus 0-5 8785405-0 1996 Accumulation of acidic renin isoforms in kidneys of cyclosporine-A-treated rats. Cyclosporine 52-66 renin Rattus norvegicus 23-28 8785405-1 1996 Chronic cyclosporin A (CsA) treatment results in major hemodynamic changes in the renal microvasculature and in expression of the intrarenal renin angiotensin system. Cyclosporine 8-21 renin Rattus norvegicus 141-146 8785405-1 1996 Chronic cyclosporin A (CsA) treatment results in major hemodynamic changes in the renal microvasculature and in expression of the intrarenal renin angiotensin system. Cyclosporine 23-26 renin Rattus norvegicus 141-146 8785405-2 1996 Changes in renin expression in kidneys of CsA-treated rats include the recruitment of immunoreactive renin in afferent arterioles and in the juxtaglomerular apparatus. Cyclosporine 42-45 renin Rattus norvegicus 11-16 8785405-2 1996 Changes in renin expression in kidneys of CsA-treated rats include the recruitment of immunoreactive renin in afferent arterioles and in the juxtaglomerular apparatus. Cyclosporine 42-45 renin Rattus norvegicus 101-106 8785405-3 1996 This study presents evidence that an acidic isoform of renin is increased in kidneys of CsA-treated rats. Cyclosporine 88-91 renin Rattus norvegicus 55-60 8785405-5 1996 Silver-stained two-dimensional gels of renin separated from kidney homogenate with pepstatin agarose confirm the presence of an acidic renin isoform in CsA-treated rats. Silver 0-6 renin Rattus norvegicus 39-44 8785405-5 1996 Silver-stained two-dimensional gels of renin separated from kidney homogenate with pepstatin agarose confirm the presence of an acidic renin isoform in CsA-treated rats. Silver 0-6 renin Rattus norvegicus 135-140 8785405-5 1996 Silver-stained two-dimensional gels of renin separated from kidney homogenate with pepstatin agarose confirm the presence of an acidic renin isoform in CsA-treated rats. pepstatin 83-92 renin Rattus norvegicus 39-44 8785405-5 1996 Silver-stained two-dimensional gels of renin separated from kidney homogenate with pepstatin agarose confirm the presence of an acidic renin isoform in CsA-treated rats. pepstatin 83-92 renin Rattus norvegicus 135-140 8785405-5 1996 Silver-stained two-dimensional gels of renin separated from kidney homogenate with pepstatin agarose confirm the presence of an acidic renin isoform in CsA-treated rats. Sepharose 93-100 renin Rattus norvegicus 39-44 8785405-5 1996 Silver-stained two-dimensional gels of renin separated from kidney homogenate with pepstatin agarose confirm the presence of an acidic renin isoform in CsA-treated rats. Sepharose 93-100 renin Rattus norvegicus 135-140 8785405-5 1996 Silver-stained two-dimensional gels of renin separated from kidney homogenate with pepstatin agarose confirm the presence of an acidic renin isoform in CsA-treated rats. Cyclosporine 152-155 renin Rattus norvegicus 39-44 8785405-5 1996 Silver-stained two-dimensional gels of renin separated from kidney homogenate with pepstatin agarose confirm the presence of an acidic renin isoform in CsA-treated rats. Cyclosporine 152-155 renin Rattus norvegicus 135-140 8785405-7 1996 Renin enzymatic activity also increased in kidney homogenate of CsA-treated rats relative to duration of treatment with CsA (r2 = 0.486, P < 0.001). Cyclosporine 64-67 renin Rattus norvegicus 0-5 8785405-9 1996 The acidic renin isoform identified in kidney homogenate of CsA-treated rats may be involved in the vascular changes that are seen in this model. Cyclosporine 60-63 renin Rattus norvegicus 11-16 8567976-4 1996 These findings demonstrate that the Dahl S strain carries alleles in or near the renin locus that confer lower plasma renin concentration and lower BP than the corresponding alleles in the Dahl R strain, at least when studied on the genetic background of the Dahl R rat and in the environment of a high salt diet. Salts 303-307 renin Rattus norvegicus 81-86 9138750-3 1996 Renin-induced natriuretic action was prevented by domperidone and by inhibition of tyrosine hydroxylase activity with alpha-methyl-p-tyrosine treatment. Domperidone 50-61 renin Rattus norvegicus 0-5 9138750-3 1996 Renin-induced natriuretic action was prevented by domperidone and by inhibition of tyrosine hydroxylase activity with alpha-methyl-p-tyrosine treatment. alpha-Methyltyrosine 118-141 renin Rattus norvegicus 0-5 9138750-5 1996 Our results suggest that renin acts centrally, at least in part, via an interaction with endogenous dopamine systems. Dopamine 100-108 renin Rattus norvegicus 25-30 8697703-8 1996 Chlorothiazide raised haematocrit and plasma renin activity equally in rats with and without infarction, although exchangeable body sodium, plasma vasopressin and plasma osmolality were not changed by the treatment. Chlorothiazide 0-14 renin Rattus norvegicus 45-50 8832271-0 1996 Effect of aging and sodium deprivation on plasma concentration of aldosterone and on plasma renin activity in the rat. Sodium 20-26 renin Rattus norvegicus 92-97 8832271-1 1996 Age-related changes in plasma aldosterone and corticosterone concentrations as well as in plasma renin activity in response to 10 days of sodium deprivation were studied in old as compared to adult male Long-Evans rats. Sodium 138-144 renin Rattus norvegicus 97-102 8832271-6 1996 Furthermore, although plasma renin activity of senescent rats, fed either a normal or a sodium-deprived diet, was lower as compared to adult rats, the absolute and percent increases of this activity in response to sodium deprivation were, respectively, similar and higher in old as compared to adult rats and so could partially contribute to the higher aldosterone response. Sodium 88-94 renin Rattus norvegicus 29-34 8832271-6 1996 Furthermore, although plasma renin activity of senescent rats, fed either a normal or a sodium-deprived diet, was lower as compared to adult rats, the absolute and percent increases of this activity in response to sodium deprivation were, respectively, similar and higher in old as compared to adult rats and so could partially contribute to the higher aldosterone response. Sodium 214-220 renin Rattus norvegicus 29-34 8730435-0 1996 Renin immunochemistry, sodium excretion and relative heart weight in cyclosporine- or alimentary-induced magnesium deficiency in rats. Cyclosporine 69-81 renin Rattus norvegicus 0-5 12013498-7 1996 Plasma renin activity also changed in opposite directions, being decreased by CCPA but increased dose-dependently by 2HE-NECA and CGS 21680 and only moderately by NECA. 2-chloro-N(6)cyclopentyladenosine 78-82 renin Rattus norvegicus 7-12 12013498-10 1996 CONCLUSIONS: These results indicate that the renin-suppressive effect of the A1 agonist, which is associated with a cardiodepressant action, may be attributed either to a direct inhibition of renin release or to the concomitant increments in plasma atrial natriuretic peptide and its second messenger, cGMP. Cyclic GMP 302-306 renin Rattus norvegicus 45-50 8591882-6 1996 These data suggest a contribution of nitric oxide to the blood pressure reduction caused by interruption of the renin-angiotensin system in models of established angiotensin-dependent hypertension. Nitric Oxide 37-49 renin Rattus norvegicus 112-117 8773357-1 1996 We examined the responses on blood pressure when the renal vasoactive system such as renin-angiotensin-aldosterone system (RAAS) and kallikrein-kinin system (KKS) was activated by dietary salt restriction in the congenitally bilateral hydronephrotic rat (BHN). Salts 188-192 renin Rattus norvegicus 85-90 8730435-0 1996 Renin immunochemistry, sodium excretion and relative heart weight in cyclosporine- or alimentary-induced magnesium deficiency in rats. Magnesium 105-114 renin Rattus norvegicus 0-5 7498983-5 1995 Plasma renin activity was elevated by losartan treatment, sodium restriction, or the combination of the two versus control (P < .05). Losartan 38-46 renin Rattus norvegicus 7-12 8594876-0 1995 Nitric oxide and prostaglandins are involved in the macula densa control of the renin system. Nitric Oxide 0-12 renin Rattus norvegicus 80-85 8594876-0 1995 Nitric oxide and prostaglandins are involved in the macula densa control of the renin system. Prostaglandins 17-31 renin Rattus norvegicus 80-85 8594876-1 1995 This study sought to examine the involvement of prostaglandins and of nitric oxide (NO) in the macula densa-dependent activation of the renin system in vivo. Nitric Oxide 70-82 renin Rattus norvegicus 136-141 8594876-4 1995 Furosemide infusion increased plasma renin activity (PRA) from 8.8 +/- 1.4 to 41 +/- 5.2 ng angiotensin I (ANG I).h-1.ml-1 and renin mRNA levels from 112 +/- 8 of standard to 249 +/- 18% of standard. Furosemide 0-10 renin Rattus norvegicus 37-42 8594876-4 1995 Furosemide infusion increased plasma renin activity (PRA) from 8.8 +/- 1.4 to 41 +/- 5.2 ng angiotensin I (ANG I).h-1.ml-1 and renin mRNA levels from 112 +/- 8 of standard to 249 +/- 18% of standard. Furosemide 0-10 renin Rattus norvegicus 127-132 8594876-5 1995 After treatment with indomethacin, the furosemide-induced increases in renin mRNA levels was attenuated to 190 +/- 11% of standard. Indomethacin 21-33 renin Rattus norvegicus 71-76 8594876-5 1995 After treatment with indomethacin, the furosemide-induced increases in renin mRNA levels was attenuated to 190 +/- 11% of standard. Furosemide 39-49 renin Rattus norvegicus 71-76 8594876-6 1995 After injections of L-NAME, both the furosemide-induced increases of renin mRNA levels and of PRA were reduced to 126 +/- 14% of standard and 22 +/- 5 ng ANG I.h-1.ml-1, respectively. NG-Nitroarginine Methyl Ester 20-26 renin Rattus norvegicus 69-74 8594876-6 1995 After injections of L-NAME, both the furosemide-induced increases of renin mRNA levels and of PRA were reduced to 126 +/- 14% of standard and 22 +/- 5 ng ANG I.h-1.ml-1, respectively. Furosemide 37-47 renin Rattus norvegicus 69-74 8594876-7 1995 These findings suggest that activation of renin gene expression by blockade of the macula densa function is dependent on intact NO and prostaglandin formation, whereas for stimulation of renin secretion mainly intact NO formation appears to be necessary. Prostaglandins 135-148 renin Rattus norvegicus 42-47 8594873-5 1995 Furosemide treatment resulted in a marked increase of both NOS and renin levels compared with controls (P < 0.05). Furosemide 0-10 renin Rattus norvegicus 67-72 9072412-6 1995 Felodipine caused an increase in plasma renin activity in each strain but the increase reached significant levels only in GH, SHR and WKY. Felodipine 0-10 renin Rattus norvegicus 40-45 9072431-0 1995 Renin-angiotensin system in the antihypertensive effect of isoteoline in spontaneously hypertensive rats. isoteolin 59-69 renin Rattus norvegicus 0-5 9072431-2 1995 The aim of the present study was to examine the effects of isoteoline (IST), a new tetrahydroaporphine derivative, on the blood pressure and some of the components of renin-angiotensin-aldosterone system (RAAS) in spontaneously hypertensive rats (SHR). isoteolin 59-69 renin Rattus norvegicus 167-172 8682057-11 1995 The renin-angiotensin-aldosterone system is also implicated in the transition to failure: SHR treated with the angiotensin converting enzyme inhibitor captopril starting at 12 months of age did not develop heart failure during the 18-24 month observation period. Captopril 151-160 renin Rattus norvegicus 4-9 7498960-8 1995 Plasma renin activity was significantly lower in the experimental groups (11.5 +/- 3 and 7.2 +/- 1.5 ng angiotensin I/mL per hour) than in controls (21.9 +/- 2.7 ng angiotensin I/mL per hour); however, no changes were observed in aldosterone levels. Aldosterone 230-241 renin Rattus norvegicus 7-12 7498960-11 1995 In conclusion, the present data indicate that long-term N omega-nitro-L-arginine administration to pregnant rats leads to increased blood pressure, reduced plasma volume expansion, lower plasma renin activity, and fetal growth retardation. Nitroarginine 56-80 renin Rattus norvegicus 194-199 7498983-5 1995 Plasma renin activity was elevated by losartan treatment, sodium restriction, or the combination of the two versus control (P < .05). Sodium 58-64 renin Rattus norvegicus 7-12 8903646-2 1995 MATERIALS AND METHODS: The effects on renin secretion of A1 (2-chloro-N6-cyclopentiladenosine) and A2 (2-hexynil-5"-N-ethyl-carboxamido-adenosine) adenosine-receptor agonists were studied in two groups of anaesthetized rats, each with one kidney surgically denervated. 2-chloro-n6-cyclopentiladenosine 61-93 renin Rattus norvegicus 38-43 8866900-8 1995 Plasma renin activity was highest in BHR given captopril, and was significantly elevated during an acute episode of AJS. Captopril 47-56 renin Rattus norvegicus 7-12 8903646-2 1995 MATERIALS AND METHODS: The effects on renin secretion of A1 (2-chloro-N6-cyclopentiladenosine) and A2 (2-hexynil-5"-N-ethyl-carboxamido-adenosine) adenosine-receptor agonists were studied in two groups of anaesthetized rats, each with one kidney surgically denervated. 2-hexynil-5"-n-ethyl-carboxamido-adenosine 103-145 renin Rattus norvegicus 38-43 8581480-0 1995 Serotonin and stress-induced increases in renin secretion are not blocked by sympathectomy/adrenal medullectomy but are blocked by beta antagonists. Serotonin 0-9 renin Rattus norvegicus 42-47 8846519-4 1995 Marked modulation of renin mRNA concentration is seen in adrenal, heart and hypothalamus in response to sodium depletion and inhibition of AII formation, as well as in models of renal and genetic hypertension in the rat. Sodium 104-110 renin Rattus norvegicus 21-26 8581480-2 1995 Two procedures that increase the secretion of renin were tested: administration of the serotonin releaser fenfluramine, which increases renin release without altering blood pressure [53], and subjecting the rats to the "psychological" stressor of conditioned emotional response (CER) stress. Fenfluramine 106-118 renin Rattus norvegicus 46-51 8581480-2 1995 Two procedures that increase the secretion of renin were tested: administration of the serotonin releaser fenfluramine, which increases renin release without altering blood pressure [53], and subjecting the rats to the "psychological" stressor of conditioned emotional response (CER) stress. Fenfluramine 106-118 renin Rattus norvegicus 136-141 8581480-3 1995 Pretreatment of rats with either the beta antagonist sotalol or the beta 1-selective antagonist atenolol completely prevented the increase in plasma renin activity and concentration caused by fenfluramine (5 mg/kg i.p.) Sotalol 53-60 renin Rattus norvegicus 149-154 8581480-3 1995 Pretreatment of rats with either the beta antagonist sotalol or the beta 1-selective antagonist atenolol completely prevented the increase in plasma renin activity and concentration caused by fenfluramine (5 mg/kg i.p.) Atenolol 96-104 renin Rattus norvegicus 149-154 8581480-3 1995 Pretreatment of rats with either the beta antagonist sotalol or the beta 1-selective antagonist atenolol completely prevented the increase in plasma renin activity and concentration caused by fenfluramine (5 mg/kg i.p.) Fenfluramine 192-204 renin Rattus norvegicus 149-154 8669290-5 1995 Renin release activated by isoproterenol (10 nmol L(-1)) was also significantly reduced with ET-1, -2 and -3 (1 nmol L(-1)). Isoproterenol 27-40 renin Rattus norvegicus 0-5 7586282-7 1995 Plasma renin activity increased 45% (P < .05) in rats in sodium balance and 127% in sodium-retaining rats. Sodium 60-66 renin Rattus norvegicus 7-12 7586282-7 1995 Plasma renin activity increased 45% (P < .05) in rats in sodium balance and 127% in sodium-retaining rats. Sodium 87-93 renin Rattus norvegicus 7-12 7581987-0 1995 Interactions between angiotensin II and norepinephrine on renin release by juxtaglomerular cells. Norepinephrine 40-54 renin Rattus norvegicus 58-63 8669290-9 1995 Most of the vasopressor and renin inhibitory effect of ETs is mediated by ETB rather than ETA receptors involving a calcium-dependent signal transduction mechanism. Calcium 116-123 renin Rattus norvegicus 28-33 8542679-14 1995 After 42 days in salt depleted rats, there was significant tubulointerstitial scarring that was associated with an increased plasma renin activity (PRA) (64 +/- 10 vs 30 +/- 4 ng AI/mL per h in the vehicle group, P < 0.05). Salts 17-21 renin Rattus norvegicus 132-137 8845072-3 1995 We investigated the effect of the angiotensin converting enzyme (ACE) inhibitor, perindopril on the renin-angiotensin system in plasma and tissues (adrenal gland and kidney), and the effect of mouse renin antibody on plasma and tissue renin activity before and after perindopril administration. Perindopril 81-92 renin Rattus norvegicus 100-105 8845072-5 1995 Perindopril significantly suppressed plasma angiotensin II (Ang II) from 19.4 +/- 2.5 pg/mL to 2.6 +/- 0.4 pg/mL, P < .0001, while markedly increasing plasma renin concentration (PRC) from 15.5 +/- 1.8 ng AngI/mL/h to 148.2 +/- 35.5 ng AngI/mL/h, P < .005 and kidney renin from 56.7 +/- 18.1 micrograms AngI/g/h to 827.4 +/- 79.1 micrograms AngI/g/h, P < .0001. Perindopril 0-11 renin Rattus norvegicus 161-166 8845072-5 1995 Perindopril significantly suppressed plasma angiotensin II (Ang II) from 19.4 +/- 2.5 pg/mL to 2.6 +/- 0.4 pg/mL, P < .0001, while markedly increasing plasma renin concentration (PRC) from 15.5 +/- 1.8 ng AngI/mL/h to 148.2 +/- 35.5 ng AngI/mL/h, P < .005 and kidney renin from 56.7 +/- 18.1 micrograms AngI/g/h to 827.4 +/- 79.1 micrograms AngI/g/h, P < .0001. Perindopril 0-11 renin Rattus norvegicus 273-278 8845072-9 1995 The antibody suppressed adrenal renin in both untreated and perindopril treated TGR(mREN-2)27 rats by 57.3 +/- 5.4% (n = 5, P < .0001) and 49.7 +/- 2.2% (n = 6, P < .0001), respectively. Perindopril 60-71 renin Rattus norvegicus 32-37 8845072-15 1995 The increased circulating renin in perindopril treated TGR(mRen-2)27 rats is rat renin derived from the kidney. Perindopril 35-46 renin Rattus norvegicus 26-31 8845072-15 1995 The increased circulating renin in perindopril treated TGR(mRen-2)27 rats is rat renin derived from the kidney. Perindopril 35-46 renin Rattus norvegicus 81-86 7485531-4 1995 Intrarenal infusions of isoproterenol (3, 30, and 100 ng.kg-1.min-1) caused dose-related increases in plasma renin activity (PRA). Isoproterenol 24-37 renin Rattus norvegicus 109-114 7485531-7 1995 This study clearly demonstrates that endogenous adenosine acts on the A1 receptor to restrain the renin release induced by activation of intrarenal beta-adrenoceptors and is not counteracted by endogenous activation of the A2 receptor. Adenosine 48-57 renin Rattus norvegicus 98-103 7485533-7 1995 Losartan reduced plasma renin activity and prevented cyclosporin-induced increment of cortical alpha 1(I) procollagen mRNA. Losartan 0-8 renin Rattus norvegicus 24-29 7558227-5 1995 The decrease in hypothalamus was abolished by 1% oral NaCl, which reduced renin mRNA by 37% in the clipped kidney and by 30% in the adrenal but did not lead to any change in the unclipped kidney or hypothalamus at day 40. Sodium Chloride 54-58 renin Rattus norvegicus 74-79 7558227-7 1995 In conclusion, we have quantified a decrease in hypothalamic renin mRNA in two-kidney, one clip rats 19 days after clipping that can be abolished by NaCl loading, whereas in the adrenal, renin mRNA was increased. Sodium Chloride 149-153 renin Rattus norvegicus 61-66 8719773-0 1995 Renin gene expression in the aging kidney: effect of sodium restriction. Sodium 53-59 renin Rattus norvegicus 0-5 8719773-8 1995 In contrast, this short term salt restriction induced a 2.3-fold increase in the renin mRNA in adult kidney, and a 1.9-fold increase in the senescent kidney. Salts 29-33 renin Rattus norvegicus 81-86 8719773-10 1995 The difference in adaptation to the early phase of salt restriction with age should not be linked to changes in renin gene transcription, but more likely to a change in the tissue response to the local renin-angiotensin system. Salts 51-55 renin Rattus norvegicus 202-207 7644529-0 1995 Tonic stimulation of renin gene expression by nitric oxide is counteracted by tonic inhibition through angiotensin II. Nitric Oxide 46-58 renin Rattus norvegicus 21-26 7657823-2 1995 Repeatedly intraperitoneal hypertonic saline-injected rats showed plasma renin activity responses to acute immobilization similar to controls, but markedly reduced plasma aldosterone responses. Sodium Chloride 27-44 renin Rattus norvegicus 73-78 7657823-3 1995 Concomitant with the increases in plasma renin activity, renin mRNA levels in the kidney were significantly increased in intraperitoneal hypertonic saline-injected rats, and these increases were prevented by beta-adrenergic receptor blockade with propranolol. Sodium Chloride 148-154 renin Rattus norvegicus 41-46 7657823-3 1995 Concomitant with the increases in plasma renin activity, renin mRNA levels in the kidney were significantly increased in intraperitoneal hypertonic saline-injected rats, and these increases were prevented by beta-adrenergic receptor blockade with propranolol. Sodium Chloride 148-154 renin Rattus norvegicus 57-62 7657823-3 1995 Concomitant with the increases in plasma renin activity, renin mRNA levels in the kidney were significantly increased in intraperitoneal hypertonic saline-injected rats, and these increases were prevented by beta-adrenergic receptor blockade with propranolol. Propranolol 247-258 renin Rattus norvegicus 41-46 7657823-3 1995 Concomitant with the increases in plasma renin activity, renin mRNA levels in the kidney were significantly increased in intraperitoneal hypertonic saline-injected rats, and these increases were prevented by beta-adrenergic receptor blockade with propranolol. Propranolol 247-258 renin Rattus norvegicus 57-62 7644529-1 1995 This study was designed to examine the possible involvement of prostaglandins and nitric oxide (NO) in the renin stimulatory effect of angiotensin II (AngII) antagonists. Prostaglandins 63-77 renin Rattus norvegicus 107-112 7644529-3 1995 Ramipril and losartan increased PRA values from 7.5 +/- 1.6 to 86 +/- 6 and 78 +/- 22 ng of AngI per h per ml and renin mRNA levels from 112 +/- 9% to 391 +/- 20% and 317 +/- 10%, respectively. Ramipril 0-8 renin Rattus norvegicus 114-119 7644529-3 1995 Ramipril and losartan increased PRA values from 7.5 +/- 1.6 to 86 +/- 6 and 78 +/- 22 ng of AngI per h per ml and renin mRNA levels from 112 +/- 9% to 391 +/- 20% and 317 +/- 10%, respectively. Losartan 13-21 renin Rattus norvegicus 114-119 7644529-5 1995 Basal renin mRNA levels also were unchanged by indomethacin, while increases in renin mRNA levels after ramipril treatment were slightly reduced by indomethacin. Ramipril 104-112 renin Rattus norvegicus 80-85 7644529-5 1995 Basal renin mRNA levels also were unchanged by indomethacin, while increases in renin mRNA levels after ramipril treatment were slightly reduced by indomethacin. Indomethacin 148-160 renin Rattus norvegicus 80-85 7644529-7 1995 Renin mRNA levels were reduced to 77 +/- 14% under basal conditions and ramipril- and losartan-induced increases in renin mRNA levels were completely blunted after addition of L-NAME. Ramipril 72-80 renin Rattus norvegicus 0-5 7644529-7 1995 Renin mRNA levels were reduced to 77 +/- 14% under basal conditions and ramipril- and losartan-induced increases in renin mRNA levels were completely blunted after addition of L-NAME. Ramipril 72-80 renin Rattus norvegicus 116-121 7644529-7 1995 Renin mRNA levels were reduced to 77 +/- 14% under basal conditions and ramipril- and losartan-induced increases in renin mRNA levels were completely blunted after addition of L-NAME. Losartan 86-94 renin Rattus norvegicus 0-5 7644529-7 1995 Renin mRNA levels were reduced to 77 +/- 14% under basal conditions and ramipril- and losartan-induced increases in renin mRNA levels were completely blunted after addition of L-NAME. Losartan 86-94 renin Rattus norvegicus 116-121 7644529-7 1995 Renin mRNA levels were reduced to 77 +/- 14% under basal conditions and ramipril- and losartan-induced increases in renin mRNA levels were completely blunted after addition of L-NAME. NG-Nitroarginine Methyl Ester 176-182 renin Rattus norvegicus 0-5 7644529-7 1995 Renin mRNA levels were reduced to 77 +/- 14% under basal conditions and ramipril- and losartan-induced increases in renin mRNA levels were completely blunted after addition of L-NAME. NG-Nitroarginine Methyl Ester 176-182 renin Rattus norvegicus 116-121 7644529-8 1995 The AngII antagonists, furthermore, induced an upstream recruitment of renin-expressing cells in the renal afferent arterioles, which was also blunted by L-NAME. NG-Nitroarginine Methyl Ester 154-160 renin Rattus norvegicus 71-76 7541779-12 1995 At this stage, rats treated with the nitric oxide inhibitor exhibited extremely variable plasma renin activity, tuft collapse in 10.1 +/- 2.2% of the glomeruli, and renal interstitial fibrosis. Nitric Oxide 37-49 renin Rattus norvegicus 96-101 7475048-5 1995 Losartan increased plasma renin levels 100-fold; plasma angiotensinogen levels decreased to 24% of control; and plasma aldosterone levels were unchanged. Losartan 0-8 renin Rattus norvegicus 26-31 7543251-0 1995 Selective neuronal nitric oxide synthase inhibition blocks furosemide-stimulated renin secretion in vivo. nitric 19-25 renin Rattus norvegicus 81-86 7543251-0 1995 Selective neuronal nitric oxide synthase inhibition blocks furosemide-stimulated renin secretion in vivo. Furosemide 59-69 renin Rattus norvegicus 81-86 7543251-3 1995 To test whether neuronal NOS mediates renin secretion, renin was stimulated by either the renal baroreceptor or the diuretic furosemide (acting through the macula densa pathway). Furosemide 125-135 renin Rattus norvegicus 55-60 7788884-2 1995 We have previously shown that in salt-depleted TG rats enhanced activation of mineralocorticoid biosynthesis is associated with selective stimulation of adrenal renin. Salts 33-37 renin Rattus norvegicus 161-166 7788884-7 1995 Low-salt diet increased both adrenal renin activity (from 31 +/- 3 to 77 +/- 4 and 85 +/- 2 ng angiotensin I.h-1.mg protein-1 at 4 and 7 days, respectively; P < .001) and mRNA (by 68.4 +/- 10% and 80 +/- 17% from baseline, P < .05). Salts 4-8 renin Rattus norvegicus 37-42 8557966-9 1995 CONCLUSION: The integrity of the brain renin-angiotensin system is necessary for the development of salt-induced hypertension in DIS rats. Salts 100-104 renin Rattus norvegicus 39-44 8557967-11 1995 Telmisartan reduced the severe glomerulosclerosis and proteinuria as well as cardiac hypertrophy observed in untreated TGR(mREN2)27 even with the lowest dose of 0.1 mg/kg, at which the blood pressure of the rats still exceeded 225 mmHg and the plasma renin-angiotensin system parameters were unchanged. Telmisartan 0-11 renin Rattus norvegicus 251-256 7541779-13 1995 Simultaneous nifedipine treatment normalized the dispersion of plasma renin levels, while preventing renal morphological abnormalities. Nifedipine 13-23 renin Rattus norvegicus 70-75 18800450-1 1995 ANGIOTENSIN II RECEPTOR ANTAGONISTS: Losartan (DuP 753, MK-954) is the prototype of a new class of orally active, non-peptide angiotensin II receptor antagonists able to inhibit the renin-angiotensin system specifically and selectively without the agonistic effects of the peptide receptor antagonists, e.g. saralasin, or the bradykinin-potentiating effects of the angiotensin converting enzyme (ACE) inhibitors. Losartan 37-45 renin Rattus norvegicus 182-187 7594436-12 1995 This suggests that the changes observed in the aorta are directly related to blood pressure or to other mechanisms independent of the renin-angiotensin system, which could be blocked by a calcium antagonist such as mibefradil. Calcium 188-195 renin Rattus norvegicus 134-139 7594436-12 1995 This suggests that the changes observed in the aorta are directly related to blood pressure or to other mechanisms independent of the renin-angiotensin system, which could be blocked by a calcium antagonist such as mibefradil. Mibefradil 215-225 renin Rattus norvegicus 134-139 18800450-1 1995 ANGIOTENSIN II RECEPTOR ANTAGONISTS: Losartan (DuP 753, MK-954) is the prototype of a new class of orally active, non-peptide angiotensin II receptor antagonists able to inhibit the renin-angiotensin system specifically and selectively without the agonistic effects of the peptide receptor antagonists, e.g. saralasin, or the bradykinin-potentiating effects of the angiotensin converting enzyme (ACE) inhibitors. Losartan 47-54 renin Rattus norvegicus 182-187 18800450-1 1995 ANGIOTENSIN II RECEPTOR ANTAGONISTS: Losartan (DuP 753, MK-954) is the prototype of a new class of orally active, non-peptide angiotensin II receptor antagonists able to inhibit the renin-angiotensin system specifically and selectively without the agonistic effects of the peptide receptor antagonists, e.g. saralasin, or the bradykinin-potentiating effects of the angiotensin converting enzyme (ACE) inhibitors. Losartan 56-62 renin Rattus norvegicus 182-187 18800450-6 1995 Virtually all of the known actions of angiotensin II, e.g. those defined by angiotensin II itself, saralasin, ACE inhibitors or renin inhibitors, are blocked by losartan, emphasizing the major role of AT1 receptors in mediating the responses of angiotensin II. Losartan 161-169 renin Rattus norvegicus 128-133 18800450-8 1995 PRECLINICAL STUDIES WITH LOSARTAN: Preclinical studies with losartan have suggested that this agent produces inhibition of the renin-angiotensin system comparable to that of ACE (and renin) inhibitors, without the bradykinin-potentiating effects. Losartan 25-33 renin Rattus norvegicus 127-132 18800450-8 1995 PRECLINICAL STUDIES WITH LOSARTAN: Preclinical studies with losartan have suggested that this agent produces inhibition of the renin-angiotensin system comparable to that of ACE (and renin) inhibitors, without the bradykinin-potentiating effects. Losartan 60-68 renin Rattus norvegicus 127-132 18800450-11 1995 A growing number of experimental studies have also shown that losartan inhibits neointimal proliferation and markedly reduces or prevents cardiovascular hypertrophy/remodeling and cardiac failure mediated by activation of the renin-angiotensin system. Losartan 62-70 renin Rattus norvegicus 226-231 8582114-0 1995 Renin mRNA concentration in rat hypothalamus is decreased by enalapril. Enalapril 61-70 renin Rattus norvegicus 0-5 7611527-4 1995 Losartan and saralasin produced remarkably similar effects on the cardiovascular, vasopressin, and renin responses to hemorrhage. Losartan 0-8 renin Rattus norvegicus 99-104 7654881-2 1995 However, agents such as captopril (CAP) and losartan (LOS) which interfere with the renin-angiotensin system effectively prevented the development of hypertension. Captopril 24-33 renin Rattus norvegicus 84-89 7654881-2 1995 However, agents such as captopril (CAP) and losartan (LOS) which interfere with the renin-angiotensin system effectively prevented the development of hypertension. Captopril 35-38 renin Rattus norvegicus 84-89 7654881-2 1995 However, agents such as captopril (CAP) and losartan (LOS) which interfere with the renin-angiotensin system effectively prevented the development of hypertension. Losartan 44-52 renin Rattus norvegicus 84-89 7654881-2 1995 However, agents such as captopril (CAP) and losartan (LOS) which interfere with the renin-angiotensin system effectively prevented the development of hypertension. Losartan 54-57 renin Rattus norvegicus 84-89 7611452-6 1995 Losartan increased renal renin expression and decreased EGF expression by 80%, regardless of UUO. Losartan 0-8 renin Rattus norvegicus 25-30 8582114-3 1995 The aim of the present study was to quantify renin mRNA in the hypothalamus in response to a low NaCl diet and angiotensin converting enzyme inhibitor treatment, both of which are well-known stimuli of renin mRNA in kidney. Sodium Chloride 97-101 renin Rattus norvegicus 45-50 8582114-12 1995 In conclusion, we have quantified renin mRNA in the rat hypothalamus and shown that it can be suppressed significantly by enalapril. Enalapril 122-131 renin Rattus norvegicus 34-39 8529044-1 1995 The present study was performed in order to examine the effects of dopamine (DA) on renin release and to clarify which subtype of DA receptor, DA1 or DA2 contributes to renin release. Dopamine 77-79 renin Rattus norvegicus 84-89 7768559-4 1995 The effect of renin on junctional conductance seems to be mainly due to the synthesis of Ang II because enalaprilat (10(-9) mol/L) dialyzed into the cell caused an appreciable reduction in the effect of renin. Enalaprilat 104-115 renin Rattus norvegicus 14-19 7768559-4 1995 The effect of renin on junctional conductance seems to be mainly due to the synthesis of Ang II because enalaprilat (10(-9) mol/L) dialyzed into the cell caused an appreciable reduction in the effect of renin. Enalaprilat 104-115 renin Rattus norvegicus 203-208 7768559-5 1995 The intracellular administration of renin (0.2 pmol/L) plus angiotensinogen (0.4 pmol/L) produced a faster and stronger fall in junctional conductance (84.3 +/- 1.35%, P < .05), and the effect was greatly reduced by enalaprilat. Enalaprilat 219-230 renin Rattus norvegicus 36-41 8529044-4 1995 In the first experiment, the changes in renin release induced by DA and the effects of a non-selective DA antagonist, haloperidol and a beta antagonist, propranolol on DA-induced renin release were examined. Propranolol 153-164 renin Rattus norvegicus 179-184 7768559-8 1995 Moreover, renin dialyzed into just one cell of the pair induced rectification of the junctional membrane, which was prevented by enalaprilat. Enalaprilat 129-140 renin Rattus norvegicus 10-15 8529044-5 1995 In the second experiment, the effect of a DA2 receptors antagonist, spiperone and of a DA1 receptor antagonist, SCH-23390 on renin release were investigated. SCH 23390 112-121 renin Rattus norvegicus 125-130 8529044-8 1995 The renin release induced by DA was inhibited by haloperidol but not by propranolol. Dopamine 29-31 renin Rattus norvegicus 4-9 8529044-8 1995 The renin release induced by DA was inhibited by haloperidol but not by propranolol. Haloperidol 49-60 renin Rattus norvegicus 4-9 7675628-0 1995 Prostaglandins are involved in the stimulation of renin gene expression in 2 kidney-1 clip rats. Prostaglandins 0-14 renin Rattus norvegicus 50-55 7651759-4 1995 Plasma renin activity was elevated by furosemide treatment. Furosemide 38-48 renin Rattus norvegicus 7-12 7675628-1 1995 This study was done to obtain information about a possible involvement of prostaglandins in the renal baroreceptor mechanism regulating renin secretion and renin gene expression. Prostaglandins 74-88 renin Rattus norvegicus 136-141 7675628-6 1995 While blood pressure, PRA and renin m-RNA levels of the contralateral kidneys were virtually unchanged by the cyclooxygenase inhibitors indomethacin and meclofenamate, renin gene expression in the clipped kidney was markedly influenced by inhibition of prostaglandin synthesis. Prostaglandins 253-266 renin Rattus norvegicus 168-173 7659950-0 1995 The effects of ZENECA ZD8731, an angiotensin II antagonist, on renin expression by juxtaglomerular cells in the rat: comparison of protein and mRNA expression as detected by immunohistochemistry and in situ hybridization. ICI D8731 15-28 renin Rattus norvegicus 63-68 7675636-4 1995 Losartan led to a fourfold increase in renin mRNA levels without changing AT1 receptor mRNA levels. Losartan 0-8 renin Rattus norvegicus 39-44 7737710-2 1995 To this end, we studied the effects of the orally active endothelin antagonist Ro 47-0203 (100 mg/kg per day) for 2 days on plasma renin activity and renal renin mRNA levels in normal rats and rats with unilateral renal artery clips (0.2 mm). Bosentan 79-89 renin Rattus norvegicus 131-136 7771573-1 1995 L-Arginine analogues, e.g., NG-nitro-L-arginine methyl ester (L-NAME), increase arterial pressure and suppress renin release in the rat. Arginine 0-10 renin Rattus norvegicus 111-116 7771573-1 1995 L-Arginine analogues, e.g., NG-nitro-L-arginine methyl ester (L-NAME), increase arterial pressure and suppress renin release in the rat. NG-Nitroarginine Methyl Ester 28-60 renin Rattus norvegicus 111-116 7771573-1 1995 L-Arginine analogues, e.g., NG-nitro-L-arginine methyl ester (L-NAME), increase arterial pressure and suppress renin release in the rat. NG-Nitroarginine Methyl Ester 62-68 renin Rattus norvegicus 111-116 7771573-4 1995 The aldosterone secretion rate, plasma renin activity, and adrenal blood flow were attenuated in rats treated with L-NAME and L-NNA compared with control animals. NG-Nitroarginine Methyl Ester 115-121 renin Rattus norvegicus 39-44 7771573-4 1995 The aldosterone secretion rate, plasma renin activity, and adrenal blood flow were attenuated in rats treated with L-NAME and L-NNA compared with control animals. H-Arg(NO2)-OH 126-131 renin Rattus norvegicus 39-44 7771573-10 1995 Overall these results suggest that L-arginine analogues attenuate aldosterone secretion by inhibiting the adrenal steroidogenic effects of endogenous or exogenous angiotensin II and/or by reducing plasma levels of renin/angiotensin. Arginine 35-45 renin Rattus norvegicus 214-219 7659950-1 1995 Changes in the mRNA and protein expression of renin-secreting cells in the juxtaglomerular apparatus (JGA) were examined in the rat following administration of ZENECA ZD8731, an angiotensin II receptor antagonist. ICI D8731 160-173 renin Rattus norvegicus 46-51 7659963-7 1995 When treatment was discontinued, the renin-producing cells redeveloped the features of smooth muscle, but, as we have shown with enalapril (angiotensin-converting enzyme inhibitor), the increase in their number persists for at least 3 mo. Enalapril 129-138 renin Rattus norvegicus 37-42 7700888-2 1995 We investigated the effects of the ACE inhibitors, captopril and perindopril, on the renin-angiotensin system (RAS) in plasma and tissues (adrenal gland and kidney) in the rat. Captopril 51-60 renin Rattus norvegicus 85-90 7721400-3 1995 This study analyzes the effects of the converting enzyme inhibitor lisinopril, which specifically interferes with the renin-angiotensin system, and the direct vasodilator dihydralazine on the renal and extrarenal expression of renin and angiotensinogen. Dihydralazine 171-184 renin Rattus norvegicus 227-232 7721400-6 1995 In the kidney, expression of the transgene and the endogenous renin gene increased, suggesting that both are modulated by lisinopril in a similar manner. Lisinopril 122-132 renin Rattus norvegicus 62-67 7721400-3 1995 This study analyzes the effects of the converting enzyme inhibitor lisinopril, which specifically interferes with the renin-angiotensin system, and the direct vasodilator dihydralazine on the renal and extrarenal expression of renin and angiotensinogen. Lisinopril 67-77 renin Rattus norvegicus 118-123 7721400-3 1995 This study analyzes the effects of the converting enzyme inhibitor lisinopril, which specifically interferes with the renin-angiotensin system, and the direct vasodilator dihydralazine on the renal and extrarenal expression of renin and angiotensinogen. Lisinopril 67-77 renin Rattus norvegicus 227-232 7700888-2 1995 We investigated the effects of the ACE inhibitors, captopril and perindopril, on the renin-angiotensin system (RAS) in plasma and tissues (adrenal gland and kidney) in the rat. Perindopril 65-76 renin Rattus norvegicus 85-90 7700888-4 1995 Perindopril markedly increased plasma renin concentration (PRC) from 12.7 +/- 1.1 to 867 +/- 59 ng Ang I/ml/hr and significantly inhibited plasma angiotensin II (Ang II) from 17.5 +/- 3.5 to 7.8 +/- 0.6 pg/ml and plasma ACE activity from 31.6 +/- 1.7 to 1.7 +/- 0.3 U/liter. Perindopril 0-11 renin Rattus norvegicus 38-43 7700888-8 1995 Perindopril increased kidney renin from 625.3 +/- 84.6 to 2152.3 +/- 233.4 micrograms/g/hr, while captopril produced a modest but insignificant rise in kidney renin (708.0 +/- 107.1 vs 1083.3 +/- 155.5 micrograms Ang I/g/hr, N.S.). Perindopril 0-11 renin Rattus norvegicus 29-34 7620835-3 1995 To determine whether ISO-induced cardiac ODC activity is mediated through the renin-angiotensin system, especially at the AT1-receptor, we used a nonpeptide AT1 receptor antagonist, losartan, in this study. Isoproterenol 21-24 renin Rattus norvegicus 78-83 7700888-8 1995 Perindopril increased kidney renin from 625.3 +/- 84.6 to 2152.3 +/- 233.4 micrograms/g/hr, while captopril produced a modest but insignificant rise in kidney renin (708.0 +/- 107.1 vs 1083.3 +/- 155.5 micrograms Ang I/g/hr, N.S.). Captopril 98-107 renin Rattus norvegicus 159-164 7755945-9 1995 There was a close correlation between the lesions of nephroangiosclerosis, left ventricular index, and plasma renin activity in L-NAME rats. NG-Nitroarginine Methyl Ester 128-134 renin Rattus norvegicus 110-115 7533733-3 1995 12-HETE is not only a potent inhibitor of basal renin secretion but also a key mediator of ANG II-induced renin inhibition. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 0-7 renin Rattus norvegicus 48-53 7533733-3 1995 12-HETE is not only a potent inhibitor of basal renin secretion but also a key mediator of ANG II-induced renin inhibition. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 0-7 renin Rattus norvegicus 106-111 7533733-6 1995 Iloprost (10(-6) mol/l), a stable analog of prostacyclin, had similar stimulatory effects on renin secretion in both normal and diabetic tissues, but the response was enhanced by LO inhibition in diabetic tissue. Iloprost 0-8 renin Rattus norvegicus 93-98 7533733-0 1995 Renin response to 12-hydroxyeicosatetraenoic acid is increased in diabetic rats. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 18-49 renin Rattus norvegicus 0-5 7533733-1 1995 Eicosanoids (prostaglandins) can alter renin secretion and angiotensin (ANG) II action. Eicosanoids 0-11 renin Rattus norvegicus 39-44 7533733-1 1995 Eicosanoids (prostaglandins) can alter renin secretion and angiotensin (ANG) II action. Prostaglandins 13-27 renin Rattus norvegicus 39-44 7533733-2 1995 We have studied the effects of both prostacyclin and a lipoxygenase (LO) product, 12-hydroxyeicosatetraenoic acid (12-HETE), on renin in normal and streptozotocin-induced diabetic rats. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 82-113 renin Rattus norvegicus 128-133 7581544-0 1995 [The heterogeneity of the reaction of plasma renin activity in the arterial blood of rats to acetylcholine infusion into the systemic blood flow]. Acetylcholine 93-106 renin Rattus norvegicus 45-50 7581544-2 1995 administration of acetylcholine in anesthetised rats with a preliminary adrenoblockade decreased the plasma renin activity (PRA) of arterial blood in rats with an increased sympathetic reactivity and a high sensitivity to acetylcholine. Acetylcholine 18-31 renin Rattus norvegicus 108-113 7581544-2 1995 administration of acetylcholine in anesthetised rats with a preliminary adrenoblockade decreased the plasma renin activity (PRA) of arterial blood in rats with an increased sympathetic reactivity and a high sensitivity to acetylcholine. Acetylcholine 222-235 renin Rattus norvegicus 108-113 8846335-1 1995 Experiments on white male rats with a traumatic shock by the Cannon method have permitted establishing that expressed activation of hypothalamo-neurohypophysial, renin-angiotensin-aldosterone and prostanoid systems induced disorders in the cardiovascular system, namely, a decrease in the heart stroke, growth of the vascular tension in the first hours of the acute period of the disease and an increase in the peripheral vascular resistance. Aldosterone 180-191 renin Rattus norvegicus 162-167 7734099-5 1995 In aortic coarcted (high renin) rats, MK-996 (3 mg/kg, by mouth) reduces blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia. MK 996 38-44 renin Rattus norvegicus 25-30 7722212-1 1995 The purpose of this study was to determine the interactions of the renin-angiotensin system with adenosine and glutamate in the area postrema (AP) of rats. Adenosine 97-106 renin Rattus norvegicus 67-72 7722212-1 1995 The purpose of this study was to determine the interactions of the renin-angiotensin system with adenosine and glutamate in the area postrema (AP) of rats. Glutamic Acid 111-120 renin Rattus norvegicus 67-72 7722212-5 1995 To test the interaction of glutamate and renin-angiotensin system, we found that glutamate antagonist, GDEE, markedly lowered depressor and bradycardic responses of Ang II but did not influence Ang III in rats. glutamic acid diethyl ester 103-107 renin Rattus norvegicus 41-46 7722212-7 1995 In conclusion, the endogenous adenosine and glutamate may influence the renin-angiotensin system on cardiovascular responses in the AP of rats. Adenosine 30-39 renin Rattus norvegicus 72-77 7722212-7 1995 In conclusion, the endogenous adenosine and glutamate may influence the renin-angiotensin system on cardiovascular responses in the AP of rats. Glutamic Acid 44-53 renin Rattus norvegicus 72-77 7712167-5 1995 Relative to captopril alone, the combination of captopril and bradykinin greatly elevated plasma renin activity, but did not reduce blood pressure. Captopril 48-57 renin Rattus norvegicus 97-102 7787694-5 1995 It is concluded that the renin-angiotension system is directly involved into the mechanism of action of cardiac glycosides in the kidneys, acting as a modulator that prevents their vasodilating and tubular effects. Glycosides 112-122 renin Rattus norvegicus 25-30 7759857-5 1995 RESULTS: As reported previously, plasma renin was suppressed during the first 4 weeks of the high-salt diet but then paradoxically increased in both strains. Salts 98-102 renin Rattus norvegicus 40-45 7759857-8 1995 In Dahl-S rats losartan treatment was associated with lower levels of plasma angiotensinogen but caused greater increases in plasma renin. Losartan 15-23 renin Rattus norvegicus 132-137 7759857-10 1995 Similarly to Dahl-S rats, plasma angiotensinogen fell in SHRSP when renin increased, but SHRSP had higher plasma angiotensinogen levels during losartan treatment because plasma renin concentration was lower. Losartan 143-151 renin Rattus norvegicus 177-182 7815350-8 1995 Intravenous RB 105 decreased blood pressure similarly in DOCA-salt, renovascular (1C-2K) and spontaneously hypertensive rats and induced a similar natriuretic response in these three different renin-dependent and -independent models of hypertension. N-(2-(mercaptomethyl)-3-phenylbutanoyl)-L-alanine 12-18 renin Rattus norvegicus 193-198 7759841-1 1995 OBJECTIVE AND DESIGN: To study the effects of blockade of the renin-angiotensin system on the development of hypertension and end-organ damage in hyporeninaemic deoxycorticosterone acetate (DOCA)-salt hypertensive rats, using an angiotensin II (Ang II) receptor antagonist (TCV-116) or an angiotensin converting enzyme (ACE) inhibitor (enalapril). Desoxycorticosterone Acetate 161-188 renin Rattus norvegicus 62-67 7759841-7 1995 However, after a further 3 weeks the renin concentration was slightly above the normal level, and this increase was accompanied by a decrease in body weight and increases in blood urea nitrogen, plasma creatinine, urinary protein and omega 3-subtype benzodiazepine receptor binding in the cerebral cortex, and by brain oedema. Nitrogen 185-193 renin Rattus norvegicus 37-42 7759841-7 1995 However, after a further 3 weeks the renin concentration was slightly above the normal level, and this increase was accompanied by a decrease in body weight and increases in blood urea nitrogen, plasma creatinine, urinary protein and omega 3-subtype benzodiazepine receptor binding in the cerebral cortex, and by brain oedema. Creatinine 202-212 renin Rattus norvegicus 37-42 7759841-10 1995 CONCLUSIONS: Although the hypertension in DOCA-salt hypertensive rats is independent of the renin-angiotensin system, the degree of cerebral and renal damage is associated with the activity of the renin-angiotensin system and has little relationship with the blood pressure level. Desoxycorticosterone Acetate 42-46 renin Rattus norvegicus 197-202 7759841-10 1995 CONCLUSIONS: Although the hypertension in DOCA-salt hypertensive rats is independent of the renin-angiotensin system, the degree of cerebral and renal damage is associated with the activity of the renin-angiotensin system and has little relationship with the blood pressure level. Salts 47-51 renin Rattus norvegicus 197-202 7815350-10 1995 RB 105 also induced an increase in urinary excretion of cGMP and bradykinin and in plasma renin concentration in hypertensive and normotensive rats. N-(2-(mercaptomethyl)-3-phenylbutanoyl)-L-alanine 0-6 renin Rattus norvegicus 90-95 7815350-11 1995 In conclusion, RB 105 is a new dual inhibitor of ACE and NEP able to target both blood pressure and renal sodium handling in different experimental renin-dependent and -independent models of hypertension. N-(2-(mercaptomethyl)-3-phenylbutanoyl)-L-alanine 15-21 renin Rattus norvegicus 148-153 7811241-4 1994 Plasma renin was high in SHR-SP/Izm and low in DOCA-salt rats. Desoxycorticosterone Acetate 47-51 renin Rattus norvegicus 7-12 7770702-6 1995 The juxtaglomerular changes were treatment- and dose-related and were attributed to an exaggerated pharmacological action of the compound, that is, ZD6888-mediated blockade of AII receptors leading to competitive inhibition of the AII-mediated release of renin. ICI D6888 148-154 renin Rattus norvegicus 255-260 7841185-0 1994 ATP-dependent transport of the linear renin-inhibiting peptide EMD 51921 by canalicular plasma membrane vesicles of rat liver: evidence of drug-stimulatable ATP-hydrolysis. Adenosine Triphosphate 0-3 renin Rattus norvegicus 38-43 7841185-0 1994 ATP-dependent transport of the linear renin-inhibiting peptide EMD 51921 by canalicular plasma membrane vesicles of rat liver: evidence of drug-stimulatable ATP-hydrolysis. Adenosine Triphosphate 157-160 renin Rattus norvegicus 38-43 7565072-0 1995 [Renin-angiotensin-aldosterone system in chronic poisoning of rats with lead and cadmium]. Cadmium 81-88 renin Rattus norvegicus 1-6 7565072-1 1995 The aim of the study was to investigate the impact of the chronic, single and combined exposure to lead and cadmium on renin-angiotensin-aldosterone system in rats. Cadmium 108-115 renin Rattus norvegicus 119-124 7565072-9 1995 In comparison to controls, in rats poisoned with cadmium, decrease in the plasma renin activity, serum angiotensin II and aldosterone concentrations were observed, but it was associated with unchanged activity of angiotensin converting enzyme. Cadmium 49-56 renin Rattus norvegicus 81-86 7565072-10 1995 The decrease in plasma renin activity depended on cadmium levels in blood. Cadmium 50-57 renin Rattus norvegicus 23-28 7565072-11 1995 In comparison to rats given cadmium, in rats treated with cadmium and lead together the inhibitor of the renin-angiotensin-aldosterone systems was weaker, although cadmium was used in the same dose. Cadmium 28-35 renin Rattus norvegicus 105-110 7565072-11 1995 In comparison to rats given cadmium, in rats treated with cadmium and lead together the inhibitor of the renin-angiotensin-aldosterone systems was weaker, although cadmium was used in the same dose. Cadmium 58-65 renin Rattus norvegicus 105-110 7565072-11 1995 In comparison to rats given cadmium, in rats treated with cadmium and lead together the inhibitor of the renin-angiotensin-aldosterone systems was weaker, although cadmium was used in the same dose. Cadmium 58-65 renin Rattus norvegicus 105-110 7538649-0 1995 Interleukin-1 beta induces the formation of nitric oxide in isolated juxtaglomerular cells: influence on renin secretion. Nitric Oxide 44-56 renin Rattus norvegicus 105-110 7538649-1 1995 Renin secretion may be modulated by nitric oxide (NO). Nitric Oxide 36-48 renin Rattus norvegicus 0-5 7538649-10 1995 Melittin or forskolin concentration dependently increased renin secretion up to 90 +/- 2%. Colforsin 12-21 renin Rattus norvegicus 58-63 7841185-4 1994 In this study we describe an ATP-dependent transport system for the enzymatically and metabolically stable hydrophobic linear renin-inhibiting peptide EMD 51921. Adenosine Triphosphate 29-32 renin Rattus norvegicus 126-131 7811241-4 1994 Plasma renin was high in SHR-SP/Izm and low in DOCA-salt rats. Salts 52-56 renin Rattus norvegicus 7-12 7529003-3 1994 Reductions (P < 0.05) in plasma renin activity and plasma aldosterone concentration were found only during treatment with 30 mg/100 ml of L-NAME. NG-Nitroarginine Methyl Ester 141-147 renin Rattus norvegicus 35-40 7810695-3 1994 Lowering the extracellular chloride concentration by either of these maneuvers significantly enhanced renin secretion rates (RSR) at a perfusion pressure of 100 mmHg. Chlorides 27-35 renin Rattus norvegicus 102-107 7810695-4 1994 Increasing pressure above 100 mmHg inhibited renin release in the presence of isethionate and acetate but not with nitrate anions. Isethionic Acid 78-89 renin Rattus norvegicus 45-50 7810695-4 1994 Increasing pressure above 100 mmHg inhibited renin release in the presence of isethionate and acetate but not with nitrate anions. Acetates 94-101 renin Rattus norvegicus 45-50 7810695-5 1994 The renin stimulatory effects of isethionate and acetate but not that of nitrate anions disappeared in the presence of bumetanide (100 mumol/l), an inhibitor of macula densa chloride transport. Isethionic Acid 33-44 renin Rattus norvegicus 4-9 7700014-3 1994 Nitroprusside, atriopeptin II and 8-Br-cGMP all increased renin release but the dose-response relationships were biphasic. 8-bromoguanosino-3',5'-cyclic monophosphorothioate 34-43 renin Rattus norvegicus 58-63 7810695-5 1994 The renin stimulatory effects of isethionate and acetate but not that of nitrate anions disappeared in the presence of bumetanide (100 mumol/l), an inhibitor of macula densa chloride transport. Acetates 49-56 renin Rattus norvegicus 4-9 7810695-5 1994 The renin stimulatory effects of isethionate and acetate but not that of nitrate anions disappeared in the presence of bumetanide (100 mumol/l), an inhibitor of macula densa chloride transport. Bumetanide 119-129 renin Rattus norvegicus 4-9 7810695-6 1994 Activation of renin secretion by isethionate and acetate was blunted with 100 pmol/l angiotensin II (ANG II), whereas tenfold higher concentrations of ANG II were required to attenuate the effect of nitrate ions. Isethionic Acid 33-44 renin Rattus norvegicus 14-19 7810695-6 1994 Activation of renin secretion by isethionate and acetate was blunted with 100 pmol/l angiotensin II (ANG II), whereas tenfold higher concentrations of ANG II were required to attenuate the effect of nitrate ions. Acetates 49-56 renin Rattus norvegicus 14-19 7810695-6 1994 Activation of renin secretion by isethionate and acetate was blunted with 100 pmol/l angiotensin II (ANG II), whereas tenfold higher concentrations of ANG II were required to attenuate the effect of nitrate ions. Nitrates 199-206 renin Rattus norvegicus 14-19 7810695-7 1994 The amount of renin released in the presence of nitrate was fully additive to RSR values obtained with maximally effective doses of isoproterenol. Nitrates 48-55 renin Rattus norvegicus 14-19 7810695-7 1994 The amount of renin released in the presence of nitrate was fully additive to RSR values obtained with maximally effective doses of isoproterenol. Isoproterenol 132-145 renin Rattus norvegicus 14-19 7810695-8 1994 These findings are consistent with the idea that impermeant anions such as isethionate and acetate enhance renin secretion from the kidneys predominantly via the tubular macula densa mechanism. Isethionic Acid 75-86 renin Rattus norvegicus 107-112 7810695-8 1994 These findings are consistent with the idea that impermeant anions such as isethionate and acetate enhance renin secretion from the kidneys predominantly via the tubular macula densa mechanism. Acetates 91-98 renin Rattus norvegicus 107-112 7810695-9 1994 The stimulatory influence of membrane-permeable nitrate anions appears to involve additional pathways and is mediated by a decreased calcium sensitivity of the renin secretory process rather than resulting from an adenosine 3",5"-cyclic monophosphate-dependent action. Nitrates 48-55 renin Rattus norvegicus 160-165 7810695-9 1994 The stimulatory influence of membrane-permeable nitrate anions appears to involve additional pathways and is mediated by a decreased calcium sensitivity of the renin secretory process rather than resulting from an adenosine 3",5"-cyclic monophosphate-dependent action. Calcium 133-140 renin Rattus norvegicus 160-165 7867037-11 1994 However, the renin-angiotensin system may play a minor role in isoprenaline induced cardiac fibrosis. Isoproterenol 63-75 renin Rattus norvegicus 13-18 7721030-12 1994 The long-term administration of NZ-105 also suppressed the elevation of systolic blood pressure and the increases of plasma renin activity and aldosterone concentration. efonidipine 32-38 renin Rattus norvegicus 124-129 7700000-4 1994 Inhibition of prostaglandin (PG) formation by meclofenamate or EDRF synthesis by L-NAME markedly attenuated the increase of renin mRNA levels in response to clipping, and a combination of PG/EDRF inhibition almost abolished the increase of renin mRNA levels. Prostaglandins 14-27 renin Rattus norvegicus 124-129 7700000-4 1994 Inhibition of prostaglandin (PG) formation by meclofenamate or EDRF synthesis by L-NAME markedly attenuated the increase of renin mRNA levels in response to clipping, and a combination of PG/EDRF inhibition almost abolished the increase of renin mRNA levels. Prostaglandins 14-27 renin Rattus norvegicus 240-245 7700000-4 1994 Inhibition of prostaglandin (PG) formation by meclofenamate or EDRF synthesis by L-NAME markedly attenuated the increase of renin mRNA levels in response to clipping, and a combination of PG/EDRF inhibition almost abolished the increase of renin mRNA levels. Prostaglandins 29-31 renin Rattus norvegicus 124-129 7700000-4 1994 Inhibition of prostaglandin (PG) formation by meclofenamate or EDRF synthesis by L-NAME markedly attenuated the increase of renin mRNA levels in response to clipping, and a combination of PG/EDRF inhibition almost abolished the increase of renin mRNA levels. Meclofenamic Acid 46-59 renin Rattus norvegicus 124-129 7700000-4 1994 Inhibition of prostaglandin (PG) formation by meclofenamate or EDRF synthesis by L-NAME markedly attenuated the increase of renin mRNA levels in response to clipping, and a combination of PG/EDRF inhibition almost abolished the increase of renin mRNA levels. NG-Nitroarginine Methyl Ester 81-87 renin Rattus norvegicus 124-129 7700000-4 1994 Inhibition of prostaglandin (PG) formation by meclofenamate or EDRF synthesis by L-NAME markedly attenuated the increase of renin mRNA levels in response to clipping, and a combination of PG/EDRF inhibition almost abolished the increase of renin mRNA levels. NG-Nitroarginine Methyl Ester 81-87 renin Rattus norvegicus 240-245 7700000-7 1994 Only converting enzyme inhibition by ramipril and blockade of Ang II-AT1 receptors by losartan attenuated the decrease of renin mRNA levels in the contralaterals to clipped kidneys. Losartan 86-94 renin Rattus norvegicus 122-127 7700009-7 1994 Ang II (0.1 microM) inhibited renin secretion by 20%, whereas the adenylyl cyclase activator forskolin (10 microM) stimulated renin secretion by 50%. Colforsin 93-102 renin Rattus norvegicus 126-131 7700009-8 1994 In arterioles isolated from rats chronically treated with a converting enzyme inhibitor (perindoprilate) to reduce endogenous formation of Ang II, renin release increased 20-fold under control conditions in vitro and was further stimulated by forskolin. perindoprilat 89-103 renin Rattus norvegicus 147-152 7700014-5 1994 Methylene blue, a guanylate cyclase inhibitor, also suppressed baseline renin release at 10(-5) and 10(-6) M, but stimulated release at 10(-3) M. Using mid-range drug concentrations, the cGMP specific phosphodiesterase inhibitor MB22948 potentiated renin release in response to nitroprusside and 8-Br-cGMP. Methylene Blue 0-14 renin Rattus norvegicus 72-77 7700009-8 1994 In arterioles isolated from rats chronically treated with a converting enzyme inhibitor (perindoprilate) to reduce endogenous formation of Ang II, renin release increased 20-fold under control conditions in vitro and was further stimulated by forskolin. Colforsin 243-252 renin Rattus norvegicus 147-152 7700014-5 1994 Methylene blue, a guanylate cyclase inhibitor, also suppressed baseline renin release at 10(-5) and 10(-6) M, but stimulated release at 10(-3) M. Using mid-range drug concentrations, the cGMP specific phosphodiesterase inhibitor MB22948 potentiated renin release in response to nitroprusside and 8-Br-cGMP. Methylene Blue 0-14 renin Rattus norvegicus 249-254 7700013-10 1994 In chromaffin cells, renin labeling was present in both cytoplasmic vesicles and electron-dense granules, while prosequence was predominantly in cytoplasmic vesicles, consistent with processing of prorenin prior to storage in chromaffin granules. chromaffin 3-13 renin Rattus norvegicus 21-26 7700014-6 1994 Inhibition of guanylate cyclase with either methylene blue or LY83583 attenuated renin release in response to nitroprusside, but, as expected, had no effect on 8-Br-cGMP induced release. Methylene Blue 44-58 renin Rattus norvegicus 81-86 7700014-0 1994 Cyclic GMP-linked pathway for renin secretion. Cyclic GMP 0-10 renin Rattus norvegicus 30-35 7700014-6 1994 Inhibition of guanylate cyclase with either methylene blue or LY83583 attenuated renin release in response to nitroprusside, but, as expected, had no effect on 8-Br-cGMP induced release. 6-anilino-5,8-quinolinedione 62-69 renin Rattus norvegicus 81-86 7700014-1 1994 The role of cGMP as a second messenger for renin secretion is contentious. Cyclic GMP 12-16 renin Rattus norvegicus 43-48 7700014-3 1994 Nitroprusside, atriopeptin II and 8-Br-cGMP all increased renin release but the dose-response relationships were biphasic. Nitroprusside 0-13 renin Rattus norvegicus 58-63 7700014-6 1994 Inhibition of guanylate cyclase with either methylene blue or LY83583 attenuated renin release in response to nitroprusside, but, as expected, had no effect on 8-Br-cGMP induced release. Nitroprusside 110-123 renin Rattus norvegicus 81-86 7700014-7 1994 We conclude that, under physiological conditions, cGMP is a stimulatory second messenger for renin release. Cyclic GMP 50-54 renin Rattus norvegicus 93-98 7700014-9 1994 In response to high doses of these drugs an unknown inhibitory pathway is activated and this opposes, in a dose-related manner, the stimulatory actions of cGMP for renin release. Cyclic GMP 155-159 renin Rattus norvegicus 164-169 7878073-7 1994 The 3 cold-treated groups (control, L-arginine and prazosin) had increases in plasma T3 and decreases in plasma T4 and plasma renin activity. Arginine 36-46 renin Rattus norvegicus 126-131 7535899-7 1994 L-NAME-induced increase in plasma renin activity (PRA) was further elevated with ramipril treatment. NG-Nitroarginine Methyl Ester 0-6 renin Rattus norvegicus 34-39 7535899-7 1994 L-NAME-induced increase in plasma renin activity (PRA) was further elevated with ramipril treatment. Ramipril 81-89 renin Rattus norvegicus 34-39 7878073-11 1994 The protective effect of arginine and prazosin in cold-induced hypertension may be related both to their reduction in plasma renin activity and to a reduced responsiveness to angiotensin II, as well as to their abilities to increase the secretion of dopamine. Arginine 25-33 renin Rattus norvegicus 125-130 7878073-7 1994 The 3 cold-treated groups (control, L-arginine and prazosin) had increases in plasma T3 and decreases in plasma T4 and plasma renin activity. Prazosin 51-59 renin Rattus norvegicus 126-131 7878073-11 1994 The protective effect of arginine and prazosin in cold-induced hypertension may be related both to their reduction in plasma renin activity and to a reduced responsiveness to angiotensin II, as well as to their abilities to increase the secretion of dopamine. Prazosin 38-46 renin Rattus norvegicus 125-130 7977842-3 1994 Rats treated jointly with furosemide and low-dose captopril had exaggerated increases in plasma renin activity and angiotensin I but equivalent increases in plasma aldosterone compared with rats treated with either agent alone. Furosemide 26-36 renin Rattus norvegicus 96-101 7865150-0 1994 Interaction of acetaldehyde with plasma proteins of the renin-angiotensin system. Acetaldehyde 15-27 renin Rattus norvegicus 56-61 7865150-5 1994 Preincubation of NEPEX plasma with 0.2 M acetaldehyde at 4 degrees C for 2 h resulted in a 21% increase in the angiotensin I (A I) formation by the rat plasma renin and 27% increase in the A I formation by the trypsinized rat plasma renin. Acetaldehyde 41-53 renin Rattus norvegicus 159-164 7865150-5 1994 Preincubation of NEPEX plasma with 0.2 M acetaldehyde at 4 degrees C for 2 h resulted in a 21% increase in the angiotensin I (A I) formation by the rat plasma renin and 27% increase in the A I formation by the trypsinized rat plasma renin. Acetaldehyde 41-53 renin Rattus norvegicus 233-238 7865150-6 1994 When the rat plasma which contains modest quantities of endogenous angiotensinogen in addition to renin was preincubated with 0.2 M acetaldehyde at 4 degrees C for 2 h, the rate of A I formation was increased by 10%. Acetaldehyde 132-144 renin Rattus norvegicus 98-103 7865150-8 1994 These results suggest the possibility of a biochemical interaction of acetaldehyde with the renin substrate which may enhance the activity of the RAS cascade, thereby contributing to hypertension in chronic alcoholics. Acetaldehyde 70-82 renin Rattus norvegicus 92-97 7977842-3 1994 Rats treated jointly with furosemide and low-dose captopril had exaggerated increases in plasma renin activity and angiotensin I but equivalent increases in plasma aldosterone compared with rats treated with either agent alone. Captopril 50-59 renin Rattus norvegicus 96-101 7977842-5 1994 The administration of a higher dose of captopril (100 mg/kg) with furosemide, a combination of drugs that does not stimulate fluid intake (29), further increased plasma renin activity and angiotensin I but prevented the rise in plasma vasopressin. Captopril 39-48 renin Rattus norvegicus 169-174 7977842-5 1994 The administration of a higher dose of captopril (100 mg/kg) with furosemide, a combination of drugs that does not stimulate fluid intake (29), further increased plasma renin activity and angiotensin I but prevented the rise in plasma vasopressin. Furosemide 66-76 renin Rattus norvegicus 169-174 7826553-3 1994 During the first 4 weeks of high-salt diet, plasma renin concentration (PRC) was appropriately suppressed but it subsequently increased paradoxically in both strains. Salts 33-37 renin Rattus norvegicus 51-56 7977783-0 1994 Influence of sodium diet on L-NAME effects on renin release and renal vasoconstriction. Sodium 13-19 renin Rattus norvegicus 46-51 7977783-0 1994 Influence of sodium diet on L-NAME effects on renin release and renal vasoconstriction. NG-Nitroarginine Methyl Ester 28-34 renin Rattus norvegicus 46-51 7977783-1 1994 The intervention of the L-arginine-NO pathway in renal vasodilation and renin secretion was studied in an isolated perfused rat kidney model. Arginine 24-34 renin Rattus norvegicus 72-77 7977783-3 1994 Renin was inhibited independently of the rise in PP, since the effect of L-NAME on renin release was the same when PP was maintained constant. NG-Nitroarginine Methyl Ester 73-79 renin Rattus norvegicus 83-88 7977783-6 1994 A similar fall in renin release was observed after L-NAME in both groups, despite a higher renin secretion rate in SD than in SR rats. NG-Nitroarginine Methyl Ester 51-57 renin Rattus norvegicus 18-23 7525476-9 1994 After sodium depletion, known to induce hyperactivity of the renin-angiotensin system, adrenal AT1A and AT1B receptor mRNA levels were increased by 60% and 110%, respectively. Sodium 6-12 renin Rattus norvegicus 61-66 7732278-7 1994 When treatment was discontinued, the renin-producing cells redeveloped the features of smooth muscle cells, but, as we have shown with enalapril (augioteusin-converting enzyme inhibitor), the increase in their number persists for at least 3 mo. Enalapril 135-144 renin Rattus norvegicus 37-42 7855049-3 1994 Cyclodextrins (CD) improved the low solubility of renin inhibitors, with beta-CD showing the best ability to dissolve renin inhibitors. Cyclodextrins 0-13 renin Rattus norvegicus 50-55 7943299-0 1994 Enhanced adrenal renin and aldosterone biosynthesis during sodium restriction in TGR (mREN2)27. Sodium 59-65 renin Rattus norvegicus 17-22 7943299-1 1994 The aim of the study was to investigate the relationships between tissue renin and the steroid production in the adrenal cortex during dietary sodium restriction in the transgenic rat (TGR) (mREN2)27. Steroids 87-94 renin Rattus norvegicus 73-78 7943299-1 1994 The aim of the study was to investigate the relationships between tissue renin and the steroid production in the adrenal cortex during dietary sodium restriction in the transgenic rat (TGR) (mREN2)27. Sodium 143-149 renin Rattus norvegicus 73-78 7943299-4 1994 Sodium restriction caused sustained increases of adrenal renin activity (from 28.5 +/- 3.5 to 87.5 +/- 4.5 ng.mg protein-1.h-1 on day 7) and of adrenal renin mRNA (+63 +/- 13 and +43 +/- 7% on days 4 and 7, respectively), whereas plasma renin activity (from 3.3 +/- 0.3 to 4.4 +/- 0.6 ng.ml-1.h-1) and renal renin activity (from 0.85 +/- 0.25 to 0.7 +/- 0.4 microgram.mg protein-1.h-1) did not change. Sodium 0-6 renin Rattus norvegicus 57-62 7943299-4 1994 Sodium restriction caused sustained increases of adrenal renin activity (from 28.5 +/- 3.5 to 87.5 +/- 4.5 ng.mg protein-1.h-1 on day 7) and of adrenal renin mRNA (+63 +/- 13 and +43 +/- 7% on days 4 and 7, respectively), whereas plasma renin activity (from 3.3 +/- 0.3 to 4.4 +/- 0.6 ng.ml-1.h-1) and renal renin activity (from 0.85 +/- 0.25 to 0.7 +/- 0.4 microgram.mg protein-1.h-1) did not change. Sodium 0-6 renin Rattus norvegicus 152-157 7943299-4 1994 Sodium restriction caused sustained increases of adrenal renin activity (from 28.5 +/- 3.5 to 87.5 +/- 4.5 ng.mg protein-1.h-1 on day 7) and of adrenal renin mRNA (+63 +/- 13 and +43 +/- 7% on days 4 and 7, respectively), whereas plasma renin activity (from 3.3 +/- 0.3 to 4.4 +/- 0.6 ng.ml-1.h-1) and renal renin activity (from 0.85 +/- 0.25 to 0.7 +/- 0.4 microgram.mg protein-1.h-1) did not change. Sodium 0-6 renin Rattus norvegicus 152-157 7943299-4 1994 Sodium restriction caused sustained increases of adrenal renin activity (from 28.5 +/- 3.5 to 87.5 +/- 4.5 ng.mg protein-1.h-1 on day 7) and of adrenal renin mRNA (+63 +/- 13 and +43 +/- 7% on days 4 and 7, respectively), whereas plasma renin activity (from 3.3 +/- 0.3 to 4.4 +/- 0.6 ng.ml-1.h-1) and renal renin activity (from 0.85 +/- 0.25 to 0.7 +/- 0.4 microgram.mg protein-1.h-1) did not change. Sodium 0-6 renin Rattus norvegicus 152-157 7529399-2 1994 In sham-clipped animals L-NAME led to a decrease of PRA from 7.5 to 2.5 ng angiotensin (ANGI).h-1.ml-1 and to a 35% decrease of renal renin m-RNA levels. NG-Nitroarginine Methyl Ester 24-30 renin Rattus norvegicus 134-139 7529399-4 1994 In the clipped kidneys renin m-RNA levels increased to 450% of control values in vehicle-treated animals and to 220% of control values in L-NAME-treated animals. NG-Nitroarginine Methyl Ester 138-144 renin Rattus norvegicus 23-28 7853791-5 1994 Renal renin mRNA levels in the clipped kidneys increased 4.8-, 2.6-, 2.5- and 1.8-fold in the clipped kidneys in vehicle, meclofenamate, L-NAME and meclofenamate/L-NAME injected animals, respectively. Meclofenamic Acid 122-135 renin Rattus norvegicus 6-11 7853791-5 1994 Renal renin mRNA levels in the clipped kidneys increased 4.8-, 2.6-, 2.5- and 1.8-fold in the clipped kidneys in vehicle, meclofenamate, L-NAME and meclofenamate/L-NAME injected animals, respectively. NG-Nitroarginine Methyl Ester 137-143 renin Rattus norvegicus 6-11 7853791-5 1994 Renal renin mRNA levels in the clipped kidneys increased 4.8-, 2.6-, 2.5- and 1.8-fold in the clipped kidneys in vehicle, meclofenamate, L-NAME and meclofenamate/L-NAME injected animals, respectively. Meclofenamic Acid 148-161 renin Rattus norvegicus 6-11 7853791-5 1994 Renal renin mRNA levels in the clipped kidneys increased 4.8-, 2.6-, 2.5- and 1.8-fold in the clipped kidneys in vehicle, meclofenamate, L-NAME and meclofenamate/L-NAME injected animals, respectively. NG-Nitroarginine Methyl Ester 162-168 renin Rattus norvegicus 6-11 7853791-6 1994 These findings indicate that both the inhibition of prostaglandin synthesis and of the formation of endothelium-derived relaxing factor (EDRF) attenuate the increase of renin gene expression and of renin secretion in response to acute unilateral renal hypoperfusion and that the effects of both maneuvers are additive. Prostaglandins 52-65 renin Rattus norvegicus 169-174 7853791-6 1994 These findings indicate that both the inhibition of prostaglandin synthesis and of the formation of endothelium-derived relaxing factor (EDRF) attenuate the increase of renin gene expression and of renin secretion in response to acute unilateral renal hypoperfusion and that the effects of both maneuvers are additive. Prostaglandins 52-65 renin Rattus norvegicus 198-203 7926285-0 1994 The cardiac renin-angiotensin system in STZ-induced diabetes. Streptozocin 40-43 renin Rattus norvegicus 12-17 7875540-2 1994 Isolated aortic segments from transgenic rats for the mouse renin gene Ren-2 were more sensitive than those from control Sprague-Dawley ones to the vasoconstrictions induced by angiotensin II and to the potentiation of norepinephrine contractions by this peptide. Norepinephrine 219-233 renin Rattus norvegicus 60-65 7875540-6 1994 These results suggest that in the aorta of transgenic rats there is a higher functional tissue renin-angiotensin system that potentiates the vascular reactivity to norepinephrine. Norepinephrine 164-178 renin Rattus norvegicus 95-100 7529399-5 1994 In the contralaterals as opposed to clipped kidneys, renin m-RNA levels decreased to 16% and 50% of the control values in vehicle- and in L-NAME-treated animals, respectively. NG-Nitroarginine Methyl Ester 138-144 renin Rattus norvegicus 53-58 7529399-8 1994 These findings suggest that EDNO is involved in the control of the renin gene by the renal perfusion pressure. edno 28-32 renin Rattus norvegicus 67-72 7855049-3 1994 Cyclodextrins (CD) improved the low solubility of renin inhibitors, with beta-CD showing the best ability to dissolve renin inhibitors. Cyclodextrins 0-13 renin Rattus norvegicus 118-123 7855049-3 1994 Cyclodextrins (CD) improved the low solubility of renin inhibitors, with beta-CD showing the best ability to dissolve renin inhibitors. Cyclodextrins 15-17 renin Rattus norvegicus 50-55 7855049-3 1994 Cyclodextrins (CD) improved the low solubility of renin inhibitors, with beta-CD showing the best ability to dissolve renin inhibitors. beta-Cyclodextrins 73-80 renin Rattus norvegicus 50-55 7855049-3 1994 Cyclodextrins (CD) improved the low solubility of renin inhibitors, with beta-CD showing the best ability to dissolve renin inhibitors. beta-Cyclodextrins 73-80 renin Rattus norvegicus 118-123 7855049-5 1994 Coadministration of beta-CD improved the intestinal absorption of some renin inhibitors with low solubility as measured by transport into the mesenteric vein in the absorption experiment using the rat intestinal loop. beta-Cyclodextrins 20-27 renin Rattus norvegicus 71-76 7855050-1 1994 The transport characteristics of the renin inhibitor ((3S,4S)-4-[N-morpholinoacetyl-(1-naphthyl)-L-alanyl-N-methyl-(4-t hiazolyl)-L- alanyl]amino-3-hydroxy-5-cyclohexyl-1-(4-pyridyl)-1-pentanone; CH3-18) in rat small intestinal brush-border membrane vesicles (BBMV) were examined by a rapid filtration technique. bbmv 260-264 renin Rattus norvegicus 37-42 7855050-5 1994 Effects of the fragments of several renin inhibitors were evaluated by their inhibitory and countertransport effects on the uptake of CH3-18. 4-N-(morpholinoacetyl-(1-naphthyl)-alanyl-N-methyl-(4-thiazolyl)-alanyl)amino-3-hydroxy-5-cyclohexyl-1-(4-pyridyl)-1-pentanone 134-140 renin Rattus norvegicus 36-41 7520668-1 1994 Nitric oxide (NO) has effects on renal blood flow, glomerular filtration rate, renin secretion, and renal sodium excretion. Nitric Oxide 0-12 renin Rattus norvegicus 79-84 7820634-2 1994 Water intake stimulated by peripheral administration of the beta-adrenergic agonist, isoproterenol is attenuated by naloxone and is thought to be mediated by release of renin and production of ANG II. Water 0-5 renin Rattus norvegicus 169-174 7820634-2 1994 Water intake stimulated by peripheral administration of the beta-adrenergic agonist, isoproterenol is attenuated by naloxone and is thought to be mediated by release of renin and production of ANG II. Isoproterenol 85-98 renin Rattus norvegicus 169-174 7820634-2 1994 Water intake stimulated by peripheral administration of the beta-adrenergic agonist, isoproterenol is attenuated by naloxone and is thought to be mediated by release of renin and production of ANG II. Naloxone 116-124 renin Rattus norvegicus 169-174 7951167-0 1994 Effect of contraceptive steroid and enalapril treatment of systolic blood pressure and plasma renin-angiotensin in the rat. Enalapril 36-45 renin Rattus norvegicus 94-99 7951167-2 1994 Here, we examined the relationship between steroid-induced hypertension and components of the renin-angiotensin system. Steroids 43-50 renin Rattus norvegicus 94-99 7951167-8 1994 Ethynyloestradiol, but not levonorgestrel treatment caused a significant increase in plasma renin concentration, plasma renin activity, and plasma angiotensin II at both 6 and 12 weeks. Ethinyl Estradiol 0-17 renin Rattus norvegicus 92-97 7951167-8 1994 Ethynyloestradiol, but not levonorgestrel treatment caused a significant increase in plasma renin concentration, plasma renin activity, and plasma angiotensin II at both 6 and 12 weeks. Ethinyl Estradiol 0-17 renin Rattus norvegicus 120-125 7951167-9 1994 Plasma renin substrate was increased by ethynyloestradiol at 3, 6 and 12 weeks, prior to the observed increase in systolic blood pressure. Ethinyl Estradiol 40-57 renin Rattus norvegicus 7-12 7951167-11 1994 Enalapril alone or in combination with ethynyloestradiol decreased plasma renin concentration, activity and angiotensin II, and in combination with levonorgestrel decreased plasma renin concentration, substrate and activity (6 weeks only) but not angiotensin II. Enalapril 0-9 renin Rattus norvegicus 74-79 7951167-11 1994 Enalapril alone or in combination with ethynyloestradiol decreased plasma renin concentration, activity and angiotensin II, and in combination with levonorgestrel decreased plasma renin concentration, substrate and activity (6 weeks only) but not angiotensin II. Ethinyl Estradiol 39-56 renin Rattus norvegicus 74-79 7951167-11 1994 Enalapril alone or in combination with ethynyloestradiol decreased plasma renin concentration, activity and angiotensin II, and in combination with levonorgestrel decreased plasma renin concentration, substrate and activity (6 weeks only) but not angiotensin II. Levonorgestrel 148-162 renin Rattus norvegicus 180-185 7951167-12 1994 The data indicate a positive relationship between hypertension and the renin-angiotensin system with ethynyloestradiol, but not levonorgestrel treatment in rats. Ethinyl Estradiol 101-118 renin Rattus norvegicus 71-76 8092258-1 1994 The renin-angiotensin system, endothelin (ET), and vasoconstrictor prostaglandins have been reported in separate studies to mediate the renal vasoconstrictor effect of cyclosporin A (CsA). Cyclosporine 168-181 renin Rattus norvegicus 4-9 8092258-1 1994 The renin-angiotensin system, endothelin (ET), and vasoconstrictor prostaglandins have been reported in separate studies to mediate the renal vasoconstrictor effect of cyclosporin A (CsA). Cyclosporine 183-186 renin Rattus norvegicus 4-9 8001727-3 1994 Our experiments charted the development of the ionic specificity of sodium appetite aroused by sodium depletion or intracerebroventricular injection of renin. Sodium 68-74 renin Rattus norvegicus 152-157 8039838-5 1994 Treatment of normal rats with the converting enzyme inhibitor ramipril (5 mg/kg twice a day) for 2 days increased renin mRNA levels in both kidneys fourfold. Ramipril 62-70 renin Rattus norvegicus 114-119 8039838-6 1994 In animals with unilateral clips, additional treatment with ramipril increased renin mRNA levels 6.4-fold in the stenosed and 3.3-fold in the intact kidneys. Ramipril 60-68 renin Rattus norvegicus 79-84 7865495-2 1994 Little information has been available so far on the role of endothelium-derived nitric oxide(EDNO) in renin-dependent, 2-kidney, 1 clip(2KIC) hypertension. Nitric Oxide 80-92 renin Rattus norvegicus 102-107 8048647-1 1994 Thirst elicited by the beta-adrenergic agonist isoproterenol in rats depends in part on the secretion of renin, the consequent synthesis of angiotensin II (ANG II), and the binding of circulating ANG II to dipsogenic receptors in the brain. Isoproterenol 47-60 renin Rattus norvegicus 105-110 8048647-5 1994 The findings confirm the widely held belief that renin-dependent thirst elicited by isoproterenol relies on ANG II binding to receptor sites at a circumventricular organ in the brain. Isoproterenol 84-97 renin Rattus norvegicus 49-54 7982288-8 1994 Losartan significantly increased plasma renin activity (PRA) by six-fold and nine-fold at doses of 1 and 10 mg/kg, respectively (P < 0.05). Losartan 0-8 renin Rattus norvegicus 40-45 8021010-8 1994 In SHR, vasoconstriction in response to angiotensinogen-rich, renin-free plasma was dose dependent, was inhibited by lisinopril, and was not found 24 hours after bilateral nephrectomy. Lisinopril 117-127 renin Rattus norvegicus 62-67 8035346-12 1994 Plasma renin was increased by 36-fold after captopril but only by 1.6-fold after alatriopril, a difference that presumably reflects the inhibition of renal renin secretion by endogenous ANF after alatriopril. Captopril 44-53 renin Rattus norvegicus 7-12 8035346-12 1994 Plasma renin was increased by 36-fold after captopril but only by 1.6-fold after alatriopril, a difference that presumably reflects the inhibition of renal renin secretion by endogenous ANF after alatriopril. alatriopril 196-207 renin Rattus norvegicus 7-12 7969778-6 1994 ICV injection of RU 24969 dose-dependently increased plasma levels of renin. icv 0-3 renin Rattus norvegicus 70-75 7969778-6 1994 ICV injection of RU 24969 dose-dependently increased plasma levels of renin. 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole 17-25 renin Rattus norvegicus 70-75 7969778-7 1994 ICV injection of the 5-HT2A/5-HT2C antagonist LY53857 (50 micrograms/kg) inhibited the renin response to peripherally injected RU 24969 (0, 1, 5 and 10 mg/kg i.p. icv 0-3 renin Rattus norvegicus 87-92 7969778-7 1994 ICV injection of the 5-HT2A/5-HT2C antagonist LY53857 (50 micrograms/kg) inhibited the renin response to peripherally injected RU 24969 (0, 1, 5 and 10 mg/kg i.p. LY 53857 46-53 renin Rattus norvegicus 87-92 7969778-9 1994 In contrast, ICV injection of p-chloroamphetamine decreased renin secretion. p-Chloroamphetamine 30-49 renin Rattus norvegicus 60-65 7969778-13 1994 Administration of prazosin (1 mg/kg s.c.), which prevents the hypertensive effects of p-chloroamphetamine, exposed a stimulatory effect of ICV-injected p-chloroamphetamine (500 micrograms/kg) on renin secretion and potentiated the effect of RU 24969 (5 mg/kg i.p.) Prazosin 18-26 renin Rattus norvegicus 195-200 7969778-13 1994 Administration of prazosin (1 mg/kg s.c.), which prevents the hypertensive effects of p-chloroamphetamine, exposed a stimulatory effect of ICV-injected p-chloroamphetamine (500 micrograms/kg) on renin secretion and potentiated the effect of RU 24969 (5 mg/kg i.p.) p-Chloroamphetamine 152-171 renin Rattus norvegicus 195-200 7969778-15 1994 In conclusion, these data suggest that both RU 24969 and p-chloroamphetamine increase renin secretion through central 5-HT receptors, and that these effects are partially obscured by their hypertensive actions. Ruthenium 44-46 renin Rattus norvegicus 86-91 7969778-15 1994 In conclusion, these data suggest that both RU 24969 and p-chloroamphetamine increase renin secretion through central 5-HT receptors, and that these effects are partially obscured by their hypertensive actions. p-Chloroamphetamine 57-76 renin Rattus norvegicus 86-91 8048628-6 1994 These data suggest that the isoelectric and glycoform heterogeneity of active renin are, in fact, closely related and may result from variable and interrelated mannose (Con A affinity) and sialic acid (charge) attachments to renin. Mannose 160-167 renin Rattus norvegicus 78-83 8048628-6 1994 These data suggest that the isoelectric and glycoform heterogeneity of active renin are, in fact, closely related and may result from variable and interrelated mannose (Con A affinity) and sialic acid (charge) attachments to renin. N-Acetylneuraminic Acid 189-200 renin Rattus norvegicus 78-83 8048628-6 1994 These data suggest that the isoelectric and glycoform heterogeneity of active renin are, in fact, closely related and may result from variable and interrelated mannose (Con A affinity) and sialic acid (charge) attachments to renin. N-Acetylneuraminic Acid 189-200 renin Rattus norvegicus 225-230 7920458-2 1994 In the present paper, we describe the effects of CP-71,362, a pentapeptide which preferentially inhibits canine (and to a lesser extent, rat) plasma renin. cp-71 49-54 renin Rattus norvegicus 149-154 7920458-9 1994 We conclude that CP-71,362 is a potent canine/rat renin inhibitor and causes profound MAP lowering in these species. cp-71 17-22 renin Rattus norvegicus 50-55 7865495-2 1994 Little information has been available so far on the role of endothelium-derived nitric oxide(EDNO) in renin-dependent, 2-kidney, 1 clip(2KIC) hypertension. edno 93-97 renin Rattus norvegicus 102-107 8024020-0 1994 Renin release in rats during blockade of nitric oxide synthesis. Nitric Oxide 41-53 renin Rattus norvegicus 0-5 8024020-2 1994 Compared with the control plasma renin of 6.0 +/- 0.7 ng angiotensin I (ANG I).ml-1.h-1, plasma renin activity was suppressed (1.8 +/- 0.2 ng ANG I.ml-1.h-1, P < 0.05) in L-NAME-treated animals in which the renal perfusion pressure was permitted to increase and reached 141 +/- 8 mmHg. NG-Nitroarginine Methyl Ester 174-180 renin Rattus norvegicus 96-101 8024020-3 1994 Plasma renin activity also was suppressed (2.5 +/- 0.4 ng ANG I.ml-1.h-1, P < 0.05) in a second L-NAME-treated group in which the renal perfusion pressure was controlled to a level of 105 +/- 5 mmHg via tightening of a suprarenal aortic snare. NG-Nitroarginine Methyl Ester 99-105 renin Rattus norvegicus 7-12 8024020-4 1994 Plasma renin activity was increased (12.0 +/- 1.4 ng ANG I.ml-1.h-1, P < 0.05) in a third L-NAME-treated group in which renal perfusion pressure was reduced to 59 +/- 1 mmHg. NG-Nitroarginine Methyl Ester 93-99 renin Rattus norvegicus 7-12 8024020-7 1994 Thus L-NAME also suppressed plasma renin activity independently of reflex reductions in renal neuroadrenergic activity even when renal perfusion pressure was controlled. NG-Nitroarginine Methyl Ester 5-11 renin Rattus norvegicus 35-40 8024020-8 1994 Infusions of sodium nitroprusside completely inhibited L-NAME-induced suppression of plasma renin activity in these renal-denervated rats. Nitroprusside 13-33 renin Rattus norvegicus 92-97 8024020-8 1994 Infusions of sodium nitroprusside completely inhibited L-NAME-induced suppression of plasma renin activity in these renal-denervated rats. NG-Nitroarginine Methyl Ester 55-61 renin Rattus norvegicus 92-97 8024020-9 1994 Nitric oxide may function as a paracrine stimulatory mechanism for the local regulation of renin release. Nitric Oxide 0-12 renin Rattus norvegicus 91-96 7954100-4 1994 Our data showed that (i) on a percentage basis the renin system supports blood pressure essentially in the same manner in normal and hypertensive rats, (ii) peripheral vascular resistance decreased when erythrocytosis was partially blocked by feeding a low-iron diet, (iii) blood volume was similar in normal and hypertensive rats, and (iv) dextrin stimulates plasma renin, packed cell volume, and blood pressure in hypertensive rats. Iron 257-261 renin Rattus norvegicus 51-56 8023970-4 1994 Renin mRNA levels were sevenfold higher in losartan-treated than in control rats, as determined by quantitative standardized dot blot analysis. Losartan 43-51 renin Rattus norvegicus 0-5 8023970-5 1994 In addition, blockade of AT1 with losartan induced recruitment of renin-synthesizing and renin-containing cells in the renal vasculature, as determined by immunocytochemistry and in situ hybridization. Losartan 34-42 renin Rattus norvegicus 66-71 8023970-5 1994 In addition, blockade of AT1 with losartan induced recruitment of renin-synthesizing and renin-containing cells in the renal vasculature, as determined by immunocytochemistry and in situ hybridization. Losartan 34-42 renin Rattus norvegicus 89-94 8023970-7 1994 Losartan induced a twofold increase in steady-state renin mRNA levels above control (P < 0.05). Losartan 0-8 renin Rattus norvegicus 52-57 7954100-4 1994 Our data showed that (i) on a percentage basis the renin system supports blood pressure essentially in the same manner in normal and hypertensive rats, (ii) peripheral vascular resistance decreased when erythrocytosis was partially blocked by feeding a low-iron diet, (iii) blood volume was similar in normal and hypertensive rats, and (iv) dextrin stimulates plasma renin, packed cell volume, and blood pressure in hypertensive rats. Dextrins 341-348 renin Rattus norvegicus 51-56 8203552-9 1994 Sodium overload aggravates the renal and systemic consequences of chronic NO inhibition by mechanisms that may include paradoxical activation of renin secretion. Sodium 0-6 renin Rattus norvegicus 145-150 7951574-0 1994 Effects of cysteamine, a somatostatin depleter, on the renin-angiotensin-aldosterone axis and glomerulosa cell growth in rats. Cysteamine 11-21 renin Rattus norvegicus 55-60 7951574-1 1994 Cysteamine, a specific somatostatin depleter, was given to male rats to clarify its role in relation to the renin-angiotensin-aldosterone (RAA) axis and glomerulosa cell growth. Cysteamine 0-10 renin Rattus norvegicus 108-113 8206591-1 1994 We have reported that streptozotocin-induced insulin-dependent diabetes mellitus in 25% reduced renal mass rats is associated with low-renin, volume-expanded hypertension and that the development of the hypertension can be prevented with insulin. Streptozocin 22-36 renin Rattus norvegicus 135-140 8090811-0 1994 ICV injection of the serotonin 5-HT1B agonist CP-93,129 increases the secretion of ACTH, prolactin, and renin and increases blood pressure by nonserotonergic mechanisms. Serotonin 21-30 renin Rattus norvegicus 104-109 8090811-0 1994 ICV injection of the serotonin 5-HT1B agonist CP-93,129 increases the secretion of ACTH, prolactin, and renin and increases blood pressure by nonserotonergic mechanisms. 2-Ethyl-1-methylpyridin-4-one 46-51 renin Rattus norvegicus 104-109 8090811-1 1994 This study tested whether a new serotonin (5-HT1B) agonist, 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxy-pyrrolo[3,2-b]pyridine (CP-93,129), could be used to study the potential role of 5-HT1B receptors in the secretion of adrenocorticotropic hormone (ACTH), prolactin, and renin. Serotonin 32-41 renin Rattus norvegicus 272-277 8090811-5 1994 ICV injections of CP-93,129 (100 micrograms/kg) increased the plasma concentrations of ACTH, prolactin, and renin. 2-Ethyl-1-methylpyridin-4-one 18-23 renin Rattus norvegicus 108-113 8090811-11 1994 In contrast, the 5-HT1A/1B/beta antagonist l-propranolol (20 micrograms/kg, ICV) inhibited the renin but not the ACTH or prolactin responses to ICV CP-93,129. l-propranolol 43-56 renin Rattus norvegicus 95-100 8070692-8 1994 UA administration brought about significant increase in plasma renin activity but not in renal cortical renin content. uranyl acetate 0-2 renin Rattus norvegicus 63-68 8188173-1 1994 Activation of antinatriuretic systems such as the renin-angiotensin system, is of major importance in the pathogenesis of sodium retention in cirrhosis. Sodium 122-128 renin Rattus norvegicus 50-55 8188173-9 1994 These results indicate that sodium-retaining, nonascitic bile duct-ligated rats show abnormalities of the intrarenal renin angiotensin system that precede changes in plasma renin activity. Sodium 28-34 renin Rattus norvegicus 117-122 8188173-9 1994 These results indicate that sodium-retaining, nonascitic bile duct-ligated rats show abnormalities of the intrarenal renin angiotensin system that precede changes in plasma renin activity. Sodium 28-34 renin Rattus norvegicus 173-178 8203557-4 1994 Treatment of rats with the beta 1-adrenoreceptor antagonist metoprolol (100 mg.kg-1.day-1) for 2 days decreased renal renin mRNA levels to 71% of control levels. Metoprolol 60-70 renin Rattus norvegicus 118-123 8203557-5 1994 Unilateral renal denervation led to a further decrease of renin mRNA levels also in metoprolol-treated animals to 60% of the values found in the contralateral kidneys. Metoprolol 84-94 renin Rattus norvegicus 58-63 8203557-9 1994 Pretreatment of the animals with metoprolol, on the other hand, prevented the rise of renin mRNA in response to hypotensive hemorrhage. Metoprolol 33-43 renin Rattus norvegicus 86-91 9296690-0 1994 [The role of renin-angiotensin system in the regulation of noradrenaline inactivation in lungs during immobilization stress in rats]. Norepinephrine 59-72 renin Rattus norvegicus 13-18 8175172-0 1994 Renal effects of captopril and nitrendipine in transgenic rats with an extra renin gene. Captopril 17-26 renin Rattus norvegicus 77-82 8175172-11 1994 The results suggest a role for the renin-angiotensin system in the maintenance of glomerular filtration rate and sodium excretion in transgenic TGR (mRen-2)27 rats. Sodium 113-119 renin Rattus norvegicus 35-40 7521451-9 1994 In contrast, spirapril decreased BP; this effect was associated with significant increments in renin and decrements in ALDO and ANF, without changes in plasma and urinary cyclic GMP. spirapril 13-22 renin Rattus norvegicus 95-100 7923894-11 1994 Renal function was impaired by CyA powder at 20 mg/kg per day and plasma renin activity (PRA) was increased by all doses of CyA powder. Cyclosporine 124-127 renin Rattus norvegicus 73-78 8058474-4 1994 In non-clipped animals furosemide increased PRA from 10 to 47 ng angiotensin I.h-1.ml-1 and raised renin mRNA levels in both kidneys 2.5-fold. Furosemide 23-33 renin Rattus norvegicus 99-104 8184893-0 1994 Renin release from permeabilized juxtaglomerular cells is stimulated by chloride but not by low calcium. Chlorides 72-80 renin Rattus norvegicus 0-5 8184893-1 1994 The intracellular concentrations of calcium and chloride have been suggested to be involved in the control of renin secretion from juxtaglomerular (JG) cells. Calcium 36-43 renin Rattus norvegicus 110-115 8184893-1 1994 The intracellular concentrations of calcium and chloride have been suggested to be involved in the control of renin secretion from juxtaglomerular (JG) cells. Chlorides 48-56 renin Rattus norvegicus 110-115 8184893-6 1994 Isosmotic increases in the chloride concentration to 25, 60, and 132 mM resulted in prompt stimulations of renin release. Chlorides 27-35 renin Rattus norvegicus 107-112 8184893-7 1994 Similarly, iodide and nitrate stimulated renin release. Iodides 11-17 renin Rattus norvegicus 41-46 8184893-7 1994 Similarly, iodide and nitrate stimulated renin release. Nitrates 22-29 renin Rattus norvegicus 41-46 8184893-9 1994 We suggest that in intact JG cells an increase in calcium inhibits renin release through activation of chloride channels followed by a drop in the intracellular chloride concentration. Calcium 50-57 renin Rattus norvegicus 67-72 8184893-9 1994 We suggest that in intact JG cells an increase in calcium inhibits renin release through activation of chloride channels followed by a drop in the intracellular chloride concentration. Chlorides 103-111 renin Rattus norvegicus 67-72 8026558-1 1994 Enhancement of activity in the renin-angiotensin system reduces voluntary ethanol consumption in rats. Ethanol 74-81 renin Rattus norvegicus 31-36 8026558-2 1994 Because angiotensin II, which is a major bioactive component of the renin-angiotensin system, stimulates the release of aldosterone, aldosterone may play a role in the reduction of ethanol intake by angiotensin II. Aldosterone 120-131 renin Rattus norvegicus 68-73 8026558-2 1994 Because angiotensin II, which is a major bioactive component of the renin-angiotensin system, stimulates the release of aldosterone, aldosterone may play a role in the reduction of ethanol intake by angiotensin II. Aldosterone 133-144 renin Rattus norvegicus 68-73 8026558-2 1994 Because angiotensin II, which is a major bioactive component of the renin-angiotensin system, stimulates the release of aldosterone, aldosterone may play a role in the reduction of ethanol intake by angiotensin II. Ethanol 181-188 renin Rattus norvegicus 68-73 8044692-5 1994 Central serotonergic function was determined by the ability of a serotonin releaser, p-chloroamphetamine (PCA), to stimulate plasma adrenocorticotropin (ACTH), corticosterone, and renin secretion in female progeny at postnatal day (PD) 30. p-Chloroamphetamine 85-104 renin Rattus norvegicus 180-185 8200490-0 1994 Intracerebroventricular injection of renin in the neonatal rat reveals a precocious sodium appetite that is dissociated from renin-aroused thirst. Sodium 84-90 renin Rattus norvegicus 37-42 8200490-3 1994 In this article we report experiments that dissociate neonatal renin-evoked sodium appetite and thirst, and establish the specificity of the appetite. Sodium 76-82 renin Rattus norvegicus 63-68 8200490-5 1994 During this developmental window, renin-evoked sodium appetite is dissociated from thirst because (a) NaCl is preferred to water, (b) the appetite develops faster than thirst, and (c) 3-day-old renin-stimulated pups will avidly lick dry NaCl. Sodium 47-53 renin Rattus norvegicus 34-39 8200490-5 1994 During this developmental window, renin-evoked sodium appetite is dissociated from thirst because (a) NaCl is preferred to water, (b) the appetite develops faster than thirst, and (c) 3-day-old renin-stimulated pups will avidly lick dry NaCl. Sodium 47-53 renin Rattus norvegicus 194-199 8200490-5 1994 During this developmental window, renin-evoked sodium appetite is dissociated from thirst because (a) NaCl is preferred to water, (b) the appetite develops faster than thirst, and (c) 3-day-old renin-stimulated pups will avidly lick dry NaCl. Sodium Chloride 102-106 renin Rattus norvegicus 34-39 8200490-5 1994 During this developmental window, renin-evoked sodium appetite is dissociated from thirst because (a) NaCl is preferred to water, (b) the appetite develops faster than thirst, and (c) 3-day-old renin-stimulated pups will avidly lick dry NaCl. Water 123-128 renin Rattus norvegicus 34-39 8200490-5 1994 During this developmental window, renin-evoked sodium appetite is dissociated from thirst because (a) NaCl is preferred to water, (b) the appetite develops faster than thirst, and (c) 3-day-old renin-stimulated pups will avidly lick dry NaCl. Sodium Chloride 237-241 renin Rattus norvegicus 34-39 8200490-5 1994 During this developmental window, renin-evoked sodium appetite is dissociated from thirst because (a) NaCl is preferred to water, (b) the appetite develops faster than thirst, and (c) 3-day-old renin-stimulated pups will avidly lick dry NaCl. Sodium Chloride 237-241 renin Rattus norvegicus 194-199 8199725-0 1994 The effect of captopril treatment and its withdrawal on the gene expression of the renin-angiotensin system. Captopril 14-23 renin Rattus norvegicus 83-88 8199725-2 1994 Chronic captopril treatment was associated with a dramatic rise in renin mRNA in the kidney and an elevation in mRNA for ACE in the liver. Captopril 8-17 renin Rattus norvegicus 67-72 8199725-3 1994 The release from captopril treatment was associated with a reversal of the increase in kidney renin mRNA but no reversal of the sustained elevation of ACE mRNA in the liver. Captopril 17-26 renin Rattus norvegicus 94-99 8199725-4 1994 In situ hybridisation revealed a localisation of renin to the area of the juxtaglomerular apparatus in the kidneys from untreated animals, but recruitment of vascular sites of renin expression in kidneys from captopril-treated animals. Captopril 209-218 renin Rattus norvegicus 176-181 8199725-7 1994 The results highlight a differential effect of captopril withdrawal upon the gene expression of the components of the renin-angiotensin system in kidney and liver. Captopril 47-56 renin Rattus norvegicus 118-123 8076427-0 1994 Vasoconstrictor responses to components of the renin-angiotensin system in cyclosporin-induced hypertension in the rat. Cyclosporine 75-86 renin Rattus norvegicus 47-52 8076427-2 1994 Since plasma renin activity is increased in cyclosporin A (CsA)-induced hypertension in the rat, the role of the vascular renin-angiotensin system (RAS) in CsA-induced hypertension was investigated in rat mesenteric resistance vessels. Cyclosporine 59-62 renin Rattus norvegicus 13-18 8076427-2 1994 Since plasma renin activity is increased in cyclosporin A (CsA)-induced hypertension in the rat, the role of the vascular renin-angiotensin system (RAS) in CsA-induced hypertension was investigated in rat mesenteric resistance vessels. Cyclosporine 156-159 renin Rattus norvegicus 122-127 8141403-5 1994 It is concluded that the integrity of renin-angiotensin mechanisms is necessary for the rapid ingestion of water and saline after furosemide and captopril and that arterial pressure modulates the behavioral responses. Water 107-112 renin Rattus norvegicus 38-43 8141403-5 1994 It is concluded that the integrity of renin-angiotensin mechanisms is necessary for the rapid ingestion of water and saline after furosemide and captopril and that arterial pressure modulates the behavioral responses. Sodium Chloride 117-123 renin Rattus norvegicus 38-43 8141403-5 1994 It is concluded that the integrity of renin-angiotensin mechanisms is necessary for the rapid ingestion of water and saline after furosemide and captopril and that arterial pressure modulates the behavioral responses. Furosemide 130-140 renin Rattus norvegicus 38-43 8141403-5 1994 It is concluded that the integrity of renin-angiotensin mechanisms is necessary for the rapid ingestion of water and saline after furosemide and captopril and that arterial pressure modulates the behavioral responses. Captopril 145-154 renin Rattus norvegicus 38-43 8144210-5 1994 The optimum pH of the renin reaction in the DBA mouse was 6.0. 1,2,5,6-dibenzanthracene 44-47 renin Rattus norvegicus 22-27 8144210-9 1994 Plasma renin activity in DBA mice increased dramatically on addition of rat angiotensinogen (from 253.4 +/- 66.7 to 225,000 +/- 48,000 ng angiotensin I/mL per hour). 1,2,5,6-dibenzanthracene 25-28 renin Rattus norvegicus 7-12 7515311-1 1994 Recent evidence in rats has indicated that angiotensinogen may be synthesised in adipose tissue surrounding blood vessels and that a local renin-angiotensin system may regulate adipose tissue blood supply and the efflux of fatty acids from fat in that species. Fatty Acids 223-234 renin Rattus norvegicus 139-144 7984271-9 1994 Additionally, the renin response to d-fenfluramine was unaltered by repeated cocaine administration, while 8-OH-DPAT did not alter renin secretion in either pretreatment group. Dexfenfluramine 36-50 renin Rattus norvegicus 18-23 8307627-10 1994 The hypertension is accompanied by increases in plasma renin activity and can be prevented with intravenous L-arginine administration. Arginine 108-118 renin Rattus norvegicus 55-60 8156394-0 1994 Brain catecholamines mediate the delayed reduction in renin release after injection of fenfluramine. Catecholamines 6-20 renin Rattus norvegicus 54-59 8156394-0 1994 Brain catecholamines mediate the delayed reduction in renin release after injection of fenfluramine. Fenfluramine 87-99 renin Rattus norvegicus 54-59 8156394-1 1994 The present studies examined whether brain or peripheral catecholaminergic mechanisms mediate the fenfluramine-induced reduction in plasma renin activity and concentration. Fenfluramine 98-110 renin Rattus norvegicus 139-144 8156394-2 1994 Fenfluramine reduced plasma renin activity and concentration to 35% of basal levels in vehicle pretreated rats. Fenfluramine 0-12 renin Rattus norvegicus 28-33 8156394-5 1994 In contrast, the suppressive effects of fenfluramine on plasma renin activity and concentration was not altered in rats that were surgically adrenal medullectomized and chemically sympathectomized by 6-OHDA. Fenfluramine 40-52 renin Rattus norvegicus 63-68 8156394-7 1994 Although yohimbine alone increased plasma renin activity and concentration, it did not prevent the suppressive effects of fenfluramine. Yohimbine 9-18 renin Rattus norvegicus 42-47 8156394-8 1994 In conclusion, the data suggest that central, but not peripheral catecholamines mediate the suppressive effect of fenfluramine on renin secretion. Fenfluramine 114-126 renin Rattus norvegicus 130-135 7954537-4 1994 Both torasemide and furosemide increased plasma renin activity and aldosterone concentration, but only torasemide significantly inhibited aldosterone-receptor binding in rat kidney. Torsemide 5-15 renin Rattus norvegicus 48-53 8282377-0 1994 DuP 753 is more effective than captopril on baroreceptor function in high-renin hypertension. Losartan 0-7 renin Rattus norvegicus 74-79 7954537-4 1994 Both torasemide and furosemide increased plasma renin activity and aldosterone concentration, but only torasemide significantly inhibited aldosterone-receptor binding in rat kidney. Furosemide 20-30 renin Rattus norvegicus 48-53 8857027-0 1994 [Plasma renin activity in tachistin-stimulated hypercalcemia and under the effect of chlorazine]. tachistin 26-35 renin Rattus norvegicus 8-13 8857027-0 1994 [Plasma renin activity in tachistin-stimulated hypercalcemia and under the effect of chlorazine]. Chlorpromazine 85-95 renin Rattus norvegicus 8-13 8857027-1 1994 The aim of the present study was to elucidate the correlation between the Renin secretion and increased Plasma Calcium concentration and the role of Calmodulin in this process. Calcium 111-118 renin Rattus norvegicus 74-79 8857027-12 1994 Our results suggest that the hypercalcemia induced by Tachistin caused a dose-dependent increase of PRA and Ca-Calmodulin complex is the dominant second messenger of Renin secretion. tachistin 54-63 renin Rattus norvegicus 166-171 7506698-1 1994 Activation of the renin-angiotensin system by sodium deficiency is associated with reciprocal changes in the expression of angiotensin II receptors in adrenal glomerulosa and vascular smooth muscle cells. Sodium 46-52 renin Rattus norvegicus 18-23 7506698-3 1994 Plasma aldosterone and renin activity were elevated in rats maintained on a low salt diet compared with normal rats and were reduced in rats maintained on a high salt diet. Salts 80-84 renin Rattus norvegicus 23-28 7506698-3 1994 Plasma aldosterone and renin activity were elevated in rats maintained on a low salt diet compared with normal rats and were reduced in rats maintained on a high salt diet. Salts 162-166 renin Rattus norvegicus 23-28 7506698-4 1994 These results are consistent with previous findings on the effects of altered dietary sodium on the renin-angiotensin system. Sodium 86-92 renin Rattus norvegicus 100-105 7511728-5 1994 In sham-operated SHR, 2-week treatment with lisinopril decreased blood pressure (BP), left ventricular (LV) weight, and total peripheral resistance (TPR) (p < 0.01 each) and increased RBF and plasma renin activity (PRA) (both p < 0.05); CO and LV end-diastolic pressure (LVEDP) were unchanged. Lisinopril 44-54 renin Rattus norvegicus 202-207 8274625-0 1994 Identification of a nonendothelial cell thromboxane-like constrictor response and its interaction with the renin-angiotensin system in the aorta of spontaneously hypertensive rats. Thromboxanes 40-51 renin Rattus norvegicus 107-112 8201847-0 1994 TCV-116, a newly developed angiotensin II receptor antagonist, induces regression of cardiac hypertrophy through suppression of the tissue renin-angiotensin system in spontaneously hypertensive rats. candesartan cilexetil 0-7 renin Rattus norvegicus 139-144 8041226-3 1994 We evaluated the role of the renin-angiotensin system in the etiology of fructose-induced hypertension. Fructose 73-81 renin Rattus norvegicus 29-34 8041226-13 1994 These results suggest that the renin-angiotensin system plays a role in the development of fructose-induced hypertension. Fructose 91-99 renin Rattus norvegicus 31-36 8238382-6 1993 Our previous studies show that both prostaglandins and lipoxygenase (LO) products of arachidonic acid play an important dual regulatory role in renin secretion; therefore, we have examined the effects of both cyclooxygenase (CO) and LO inhibition in TGF-beta action. Prostaglandins 36-50 renin Rattus norvegicus 144-149 8238566-1 1993 Besides cardiac volume overload, cardiac sympathetic activity and the renin-angiotensin system (RAS) are activated by arterial vasodilators such as minoxidil. Minoxidil 148-157 renin Rattus norvegicus 70-75 8238566-2 1993 To evaluate the possible involvement of the RAS in the development of minoxidil-induced cardiac hypertrophy, we assessed in normotensive rats minoxidil-induced changes in cardiac and plasma renin activity (PRA) and the potential of chronic treatment with the angiotensin-converting enzyme (ACE) inhibitor enalapril and the nonpeptide angiotensin II receptor blocker losartan to prevent minoxidil-induced cardiac hypertrophy. Minoxidil 142-151 renin Rattus norvegicus 190-195 8292059-14 1993 This result suggests that the renin-angiotensin-aldosterone system directly or indirectly participates in the cardiac hypertrophy induced by isoproterenol. Isoproterenol 141-154 renin Rattus norvegicus 30-35 7937353-3 1994 In salt-loaded rats, plasma angiotensin(1-7) levels increased fourfold; however, other components of the renin-angiotensin system were suppressed or unchanged. Salts 3-7 renin Rattus norvegicus 105-110 7862874-8 1994 Finally, repeated cocaine exposure modified the immobilization stress-induced elevation of renin secretion; low doses of cocaine (1 or 5 mg/kg) attenuated, while higher doses (10 mg/kg) potentiated the renin response to immobilization stress. Cocaine 18-25 renin Rattus norvegicus 91-96 7862874-8 1994 Finally, repeated cocaine exposure modified the immobilization stress-induced elevation of renin secretion; low doses of cocaine (1 or 5 mg/kg) attenuated, while higher doses (10 mg/kg) potentiated the renin response to immobilization stress. Cocaine 18-25 renin Rattus norvegicus 202-207 7862874-8 1994 Finally, repeated cocaine exposure modified the immobilization stress-induced elevation of renin secretion; low doses of cocaine (1 or 5 mg/kg) attenuated, while higher doses (10 mg/kg) potentiated the renin response to immobilization stress. Cocaine 121-128 renin Rattus norvegicus 91-96 8149234-1 1993 Stimulation of the peripheral renin-angiotensin system has been shown previously to decrease the voluntary intake of ethanol in the rat. Ethanol 117-124 renin Rattus norvegicus 30-35 8149234-3 1993 The brain renin-angiotensin system plays an important role in the regulation of water and electrolyte balance and neuroendocrine function. Water 80-85 renin Rattus norvegicus 10-15 8130360-0 1993 The renin-angiotensin system in streptozotocin-induced diabetes mellitus in the rat. Streptozocin 32-46 renin Rattus norvegicus 4-9 7505348-0 1993 Renal vascular induction of TGF-beta 2 and renin by potassium depletion. Potassium 52-61 renin Rattus norvegicus 43-48 7505348-6 1993 Potassium depletion induced both TGF-beta 2 and renin immunoreactivity in renal arterioles and the JGA but had no effect on TGF-beta 1 and TGF-beta 3 isoforms. Potassium 0-9 renin Rattus norvegicus 48-53 8238382-6 1993 Our previous studies show that both prostaglandins and lipoxygenase (LO) products of arachidonic acid play an important dual regulatory role in renin secretion; therefore, we have examined the effects of both cyclooxygenase (CO) and LO inhibition in TGF-beta action. Arachidonic Acid 85-101 renin Rattus norvegicus 144-149 8353884-0 1993 Influence of the status of the renin-angiotensin system on the effect of cilazapril on neointima formation after vascular injury in rats. Cilazapril 73-83 renin Rattus norvegicus 31-36 8258664-2 1993 DESIGN: The effects of unilateral renal denervation and of treatment with an angiotensin II antagonist (losartan) on renal renin gene expression were examined in a two-kidney, one-clip model. Losartan 104-112 renin Rattus norvegicus 123-128 8258664-8 1993 Treatment of the rats with losartan led to fourfold increases in renal renin messenger RNA levels and to sixfold increases in plasma renin activity in control rats. Losartan 27-35 renin Rattus norvegicus 71-76 8258664-8 1993 Treatment of the rats with losartan led to fourfold increases in renal renin messenger RNA levels and to sixfold increases in plasma renin activity in control rats. Losartan 27-35 renin Rattus norvegicus 133-138 8258666-11 1993 CONCLUSIONS: These findings suggest that both vasopressin and the renin-angiotensin system contribute to the pathogenesis of Dahl salt-sensitive hypertension, but that other factors, possibly including the sympathetic nervous system, are also involved. dahl salt 125-134 renin Rattus norvegicus 66-71 8258672-7 1993 L-NAME resulted in a fourfold increase in plasma renin which remained elevated after treatment was stopped. NG-Nitroarginine Methyl Ester 0-6 renin Rattus norvegicus 49-54 8258672-12 1993 CONCLUSIONS: Chronic L-NAME treatment in young rats can produce a form of persistent hypertension which is renin-dependent and which does not seem to involve a vascular amplifier mechanism. NG-Nitroarginine Methyl Ester 21-27 renin Rattus norvegicus 107-112 8272384-0 1993 Influence of dietary NaCl intake on renin gene expression in the kidneys and adrenal glands of rats. Sodium Chloride 21-25 renin Rattus norvegicus 36-41 8272384-1 1993 The aim of this study was to examine the influence of dietary NaCl intake on renin gene expression in the kidneys and adrenal glands of adult rats. Sodium Chloride 62-66 renin Rattus norvegicus 77-82 8272384-9 1993 Renal nerve section led to a 50% decrease of renin mRNA levels in the denervated kidneys in animals kept on the normal-salt diet. Salts 119-123 renin Rattus norvegicus 45-50 8272384-10 1993 In the animals on the low-salt diet renin mRNA rose to similar levels in the denervated to those in the innervated kidney, while in animals receiving a high-salt diet renin mRNA was further decreased in the denervated kidneys. Salts 26-30 renin Rattus norvegicus 36-41 8272384-10 1993 In the animals on the low-salt diet renin mRNA rose to similar levels in the denervated to those in the innervated kidney, while in animals receiving a high-salt diet renin mRNA was further decreased in the denervated kidneys. Salts 157-161 renin Rattus norvegicus 167-172 8243563-0 1993 Repeated exposure to cocaine produces long-lasting deficits in the serotonergic stimulation of prolactin and renin, but not adrenocorticotropin secretion. Cocaine 21-28 renin Rattus norvegicus 109-114 8243563-2 1993 In cocaine-pretreated rats, the p-chloroamphetamine-induced elevations of prolactin and renin secretion were significantly reduced for 8 and 4 weeks, respectively. Cocaine 3-10 renin Rattus norvegicus 88-93 8243563-2 1993 In cocaine-pretreated rats, the p-chloroamphetamine-induced elevations of prolactin and renin secretion were significantly reduced for 8 and 4 weeks, respectively. p-Chloroamphetamine 32-51 renin Rattus norvegicus 88-93 7691341-0 1993 The central effects of a nitric oxide synthase inhibitor (N omega-nitro-L-arginine) on blood pressure and plasma renin. Nitric Oxide 25-37 renin Rattus norvegicus 113-118 7691341-0 1993 The central effects of a nitric oxide synthase inhibitor (N omega-nitro-L-arginine) on blood pressure and plasma renin. Nitroarginine 58-82 renin Rattus norvegicus 113-118 7691341-3 1993 The goal of our study was to determine if the increase in blood pressure following central NO synthase inhibition with N omega-nitro-L-arginine (L-NNA) is caused by the release of renin. Nitroarginine 119-143 renin Rattus norvegicus 180-185 7691341-3 1993 The goal of our study was to determine if the increase in blood pressure following central NO synthase inhibition with N omega-nitro-L-arginine (L-NNA) is caused by the release of renin. Nitroarginine 145-150 renin Rattus norvegicus 180-185 7691341-26 1993 We conclude that L-NNA acts directly within the central nervous system to increase blood pressure by a renin-independent mechanism. Nitroarginine 17-22 renin Rattus norvegicus 103-108 8258954-10 1993 Basal renin release was inversely related with perfusate calcium and was depressed by the calcium ionophore BAY-K8644. Calcium 57-64 renin Rattus norvegicus 6-11 8258954-10 1993 Basal renin release was inversely related with perfusate calcium and was depressed by the calcium ionophore BAY-K8644. Calcium 90-97 renin Rattus norvegicus 6-11 8258954-10 1993 Basal renin release was inversely related with perfusate calcium and was depressed by the calcium ionophore BAY-K8644. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 108-117 renin Rattus norvegicus 6-11 8258954-12 1993 Removing calcium abolished renin responses. Calcium 9-16 renin Rattus norvegicus 27-32 8258954-13 1993 PTHrP reversed the inhibiting effects of hypercalcic media or BAY-K8644 on basal renin release. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 62-71 renin Rattus norvegicus 81-86 8258954-14 1993 The results support calcium-mediated renin stimulating properties for PTHrP, via PTH receptors, independently from baroreceptors, macula densa and prostaglandins. Calcium 20-27 renin Rattus norvegicus 37-42 8349331-4 1993 The plasma renin activity of L-NAME rats was not significantly different from that of control rats. NG-Nitroarginine Methyl Ester 29-35 renin Rattus norvegicus 11-16 8312802-0 1993 [The effect of phenothiazine derivatives that inhibit glucocorticoid receptor function on the state of the renin-angiotensin system]. phenothiazine 15-28 renin Rattus norvegicus 107-112 8312802-3 1993 Tisercin was found to inhibit the activity of ACE and enhanced that of renin and elevated the levels of aldosterone in the serum and lung cytosol 24 hours following the agent administration. Methotrimeprazine 0-8 renin Rattus norvegicus 71-76 8271212-3 1993 To this end we investigated the effects of frusemide and bumetanide, two different inhibitors of the macula densa Na(+)-K(+)-2Cl- cotransport, on pressure-dependent renin release from isolated perfused rat kidneys. Furosemide 43-52 renin Rattus norvegicus 165-170 8254178-10 1993 CONCLUSIONS: These results demonstrate that the transcapillary shift of fluid induced by nicardipine is independent of ANP and requires the presence of a functional renin-angiotensin system, whereas its hypotensive action is independent of both ANP and angiotensin II. Nicardipine 89-100 renin Rattus norvegicus 165-170 8271212-3 1993 To this end we investigated the effects of frusemide and bumetanide, two different inhibitors of the macula densa Na(+)-K(+)-2Cl- cotransport, on pressure-dependent renin release from isolated perfused rat kidneys. Bumetanide 57-67 renin Rattus norvegicus 165-170 8271212-10 1993 The vasorelaxant effects of frusemide and bumetanide were paralleled by an increase of renin secretion to a maximum of 21 +/- 4 (ng Ang I h-1) min-1 g-1 (n = 10). Furosemide 28-37 renin Rattus norvegicus 87-92 8271212-10 1993 The vasorelaxant effects of frusemide and bumetanide were paralleled by an increase of renin secretion to a maximum of 21 +/- 4 (ng Ang I h-1) min-1 g-1 (n = 10). Bumetanide 42-52 renin Rattus norvegicus 87-92 8271212-11 1993 On a molar basis bumetanide was twice as potent as frusemide in stimulating renin secretion. Bumetanide 17-27 renin Rattus norvegicus 76-81 8271212-11 1993 On a molar basis bumetanide was twice as potent as frusemide in stimulating renin secretion. Furosemide 51-60 renin Rattus norvegicus 76-81 8271212-14 1993 In the presence of frusemide (100 microM) and bumetanide (50 microM) renin secretion rates at 40 mmHg were 97 +/- 11 and 133 +/- 24 (ng Ang I h-1) min-1 g-1 (n = 6), respectively. Bumetanide 46-56 renin Rattus norvegicus 69-74 8271212-15 1993 Renin release stimulated by bumetanide was significantly reduced to 8.0 +/- 1.5 (ng Ang I h-1) min-1 g-1 (n = 5) by elevating the perfusion pressure from 100 to 140 mmHg. Bumetanide 28-38 renin Rattus norvegicus 0-5 8214424-0 1993 Chronic ethanol ingestion modifies the renin-aldosterone axis independent of alterations in the regulation of atrial natriuretic peptide. Ethanol 8-15 renin Rattus norvegicus 39-44 8255723-0 1993 Furosemide stimulates renin expression in the kidneys of salt-supplemented rats. Furosemide 0-10 renin Rattus norvegicus 22-27 8255723-0 1993 Furosemide stimulates renin expression in the kidneys of salt-supplemented rats. Salts 57-61 renin Rattus norvegicus 22-27 8255723-1 1993 This study was conducted to obtain information about a possible influence of salt transport by the thick ascending limb of Henle (TALH) and the macula densa on the expression of renin in the kidney. Salts 77-81 renin Rattus norvegicus 178-183 8255723-5 1993 Plasma renin activities increased from 2.9 +/- 0.5 ng angiotensin I h-1 ml-1 in controls to 10.6 +/- 2.2 ng angiotensin I h-1 ml-1 in furosemide-treated rats. Furosemide 134-144 renin Rattus norvegicus 7-12 8255723-6 1993 In parallel, kidney areas immunoreactive for renin increased by 80% and the renal content of renin mRNA increased by 120% in the animals receiving furosemide. Furosemide 147-157 renin Rattus norvegicus 45-50 8255723-6 1993 In parallel, kidney areas immunoreactive for renin increased by 80% and the renal content of renin mRNA increased by 120% in the animals receiving furosemide. Furosemide 147-157 renin Rattus norvegicus 93-98 8255723-7 1993 Under the assumption that the effects seen on renal renin expression were primarily due to the inhibition of TALH and macula densa function by furosemide, our findings suggest that salt transport across the TALH and macula densa exerts a negative control function not only on the secretion but also on the expression of renin in the kidney. talh 109-113 renin Rattus norvegicus 52-57 8255723-7 1993 Under the assumption that the effects seen on renal renin expression were primarily due to the inhibition of TALH and macula densa function by furosemide, our findings suggest that salt transport across the TALH and macula densa exerts a negative control function not only on the secretion but also on the expression of renin in the kidney. Furosemide 143-153 renin Rattus norvegicus 52-57 8255723-7 1993 Under the assumption that the effects seen on renal renin expression were primarily due to the inhibition of TALH and macula densa function by furosemide, our findings suggest that salt transport across the TALH and macula densa exerts a negative control function not only on the secretion but also on the expression of renin in the kidney. Salts 181-185 renin Rattus norvegicus 52-57 8255723-7 1993 Under the assumption that the effects seen on renal renin expression were primarily due to the inhibition of TALH and macula densa function by furosemide, our findings suggest that salt transport across the TALH and macula densa exerts a negative control function not only on the secretion but also on the expression of renin in the kidney. Salts 181-185 renin Rattus norvegicus 320-325 8255723-7 1993 Under the assumption that the effects seen on renal renin expression were primarily due to the inhibition of TALH and macula densa function by furosemide, our findings suggest that salt transport across the TALH and macula densa exerts a negative control function not only on the secretion but also on the expression of renin in the kidney. talh 207-211 renin Rattus norvegicus 52-57 8210520-7 1993 However, we previously reported for these same experiments that infusion of iso-rANP(1-45) and iso-rANP(17-45) increased plasma ANP and decreased plasma renin activity. iso-ranp 76-84 renin Rattus norvegicus 153-158 8214424-6 1993 Plasma renin activity was significantly elevated in response to ethanol treatment, whereas circulating aldosterone concentration was reduced. Ethanol 64-71 renin Rattus norvegicus 7-12 8342700-1 1993 The present experiments describe a marked nycthemeral rhythm in both the appetite for 0.3 M NaCl solution and components of the renin-angiotensin-aldosterone axis stimulated in Sprague-Dawley rats by chronic administration of enalapril, an angiotensin I-converting enzyme inhibitor. Enalapril 226-235 renin Rattus norvegicus 128-133 8342700-5 1993 In a second experiment, it was determined that plasma renin activity (PRA) was maximally elevated by chronic enalapril in the daytime and that plasma aldosterone was reduced by enalapril but continued to show nycthemeral rhythm peaking in the afternoon. Enalapril 109-118 renin Rattus norvegicus 54-59 8516350-2 1993 Within 2 weeks of initiation of dietary treatments, rats fed supplemental chloride had elevated blood pressure and lowered plasma renin activity, which persisted throughout the 8-week study. Chlorides 74-82 renin Rattus norvegicus 130-135 8264857-14 1993 Finally, 5-HT suppressed, while 2-methylserotonin stimulated renin secretion. 2-methyl-5-HT 32-49 renin Rattus norvegicus 61-66 8331555-2 1993 2-Methylthio ATP (10-500 microM) and ATP (100-500 microM) stimulated renin secretion in a concentration-dependent manner and 2-methylthio ATP was the more potent. 2-methylthio-ATP 0-16 renin Rattus norvegicus 69-74 8331555-2 1993 2-Methylthio ATP (10-500 microM) and ATP (100-500 microM) stimulated renin secretion in a concentration-dependent manner and 2-methylthio ATP was the more potent. Adenosine Triphosphate 13-16 renin Rattus norvegicus 69-74 8331555-2 1993 2-Methylthio ATP (10-500 microM) and ATP (100-500 microM) stimulated renin secretion in a concentration-dependent manner and 2-methylthio ATP was the more potent. 2-methylthio-ATP 125-141 renin Rattus norvegicus 69-74 8331555-4 1993 This order of potency (2-methylthio ATP > ATP > alpha, beta-methylene ATP) indicates that activation of the P2y subclass of purinergic receptors stimulates renin secretion. 2-methylthio-ATP 23-39 renin Rattus norvegicus 162-167 8331555-4 1993 This order of potency (2-methylthio ATP > ATP > alpha, beta-methylene ATP) indicates that activation of the P2y subclass of purinergic receptors stimulates renin secretion. Adenosine Triphosphate 36-39 renin Rattus norvegicus 162-167 8331555-4 1993 This order of potency (2-methylthio ATP > ATP > alpha, beta-methylene ATP) indicates that activation of the P2y subclass of purinergic receptors stimulates renin secretion. , beta-methylene 59-75 renin Rattus norvegicus 162-167 8331555-4 1993 This order of potency (2-methylthio ATP > ATP > alpha, beta-methylene ATP) indicates that activation of the P2y subclass of purinergic receptors stimulates renin secretion. Adenosine Triphosphate 45-48 renin Rattus norvegicus 162-167 8331555-6 1993 In contrast, N omega-nitro-I-arginine methyl ester both antagonized the basal renin secretory rate and blocked the stimulating effects on renin secretion of 2-methylthio ATP. n omega-nitro-i-arginine methyl ester 13-50 renin Rattus norvegicus 78-83 8331555-6 1993 In contrast, N omega-nitro-I-arginine methyl ester both antagonized the basal renin secretory rate and blocked the stimulating effects on renin secretion of 2-methylthio ATP. n omega-nitro-i-arginine methyl ester 13-50 renin Rattus norvegicus 138-143 8331555-6 1993 In contrast, N omega-nitro-I-arginine methyl ester both antagonized the basal renin secretory rate and blocked the stimulating effects on renin secretion of 2-methylthio ATP. 2-methylthio-ATP 157-173 renin Rattus norvegicus 138-143 8331555-7 1993 Because N omega-nitro-l-arginine methyl ester antagonizes the production of nitric oxide by endothelial cells, these results suggest that nitric acid stimulates basal renin secretion in this experimental preparation and that increased production of it mediates the stimulating effects on renin secretion of activation of P2y purinergic receptors. NG-Nitroarginine Methyl Ester 8-45 renin Rattus norvegicus 288-293 8331555-7 1993 Because N omega-nitro-l-arginine methyl ester antagonizes the production of nitric oxide by endothelial cells, these results suggest that nitric acid stimulates basal renin secretion in this experimental preparation and that increased production of it mediates the stimulating effects on renin secretion of activation of P2y purinergic receptors. Nitric Acid 138-149 renin Rattus norvegicus 167-172 8322939-2 1993 The salt-deficient diet was associated with lower body weight, higher plasma renin activity in both 2K,1C and 2K shams (P < 0.004) and higher hematocrit in 2K,1C (P < 0.02). Salts 4-8 renin Rattus norvegicus 77-82 8318591-6 1993 Furthermore, renin gene expression in the coagulating gland was positively regulated by testosterone. Testosterone 88-100 renin Rattus norvegicus 13-18 8099346-6 1993 Plasma renin activity was measured on day 2 of 0.4% NaCl, days 2 and 9 of 8.0% NaCl, and day 2 of the recovery period. Sodium Chloride 52-56 renin Rattus norvegicus 7-12 8102931-7 1993 Plasma renin activity was significantly (P < 0.05) higher in captopril-treated rats (24.7 +/- 4.6 ng angiotensin I ml-1 h-1) than in either carvedilol-treated (7.9 +/- 1.4 ng angiotensin I ml-1 h-1) or control animals (7.4 +/- 1.0 ng angiotensin I ml-1 h-1). Captopril 64-73 renin Rattus norvegicus 7-12 8102931-7 1993 Plasma renin activity was significantly (P < 0.05) higher in captopril-treated rats (24.7 +/- 4.6 ng angiotensin I ml-1 h-1) than in either carvedilol-treated (7.9 +/- 1.4 ng angiotensin I ml-1 h-1) or control animals (7.4 +/- 1.0 ng angiotensin I ml-1 h-1). Carvedilol 143-153 renin Rattus norvegicus 7-12 8099346-6 1993 Plasma renin activity was measured on day 2 of 0.4% NaCl, days 2 and 9 of 8.0% NaCl, and day 2 of the recovery period. Sodium Chloride 79-83 renin Rattus norvegicus 7-12 8099346-11 1993 During 0.4% NaCl, plasma renin activity was similar in prazosin (2.9 +/- 0.8 ng/mL per hour) and vehicle (4.1 +/- 0.7 ng/mL per hour) groups and was equally suppressed during 8.0% NaCl. Prazosin 55-63 renin Rattus norvegicus 25-30 8491500-10 1993 Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p < 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p < 0.01). Genistein 5-14 renin Rattus norvegicus 79-84 8389858-1 1993 Nitrate tolerance has been explained by 1) a direct loss of pharmacological effect due to reduced bioconversion and 2) an indirect effect due to activation of the renin/angiotensin system and counter-regulatory vasoconstriction. Nitrates 0-7 renin Rattus norvegicus 163-168 8389858-11 1993 The results suggest that sulfhydryl supplementation modifies the function of the renin/angiotensin system in vivo, an effect probably mediated by inhibition of angiotensin converting enzyme activity. Sulfhydryl Compounds 25-35 renin Rattus norvegicus 81-86 8319760-2 1993 The results suggest a possible involvement of the renin-angiotensin system in the development of puromycin aminonucleoside-induced nephrosis. Puromycin Aminonucleoside 97-122 renin Rattus norvegicus 50-55 8390268-4 1993 In 25-DM rats, blood pressure progressively increased during the 3 weeks after STZ treatment and was associated with microalbuminuria, low plasma renin activity, and extracellular volume expansion. Streptozocin 79-82 renin Rattus norvegicus 146-151 8498591-7 1993 These findings suggest that the delayed response of the renin-angiotensin-aldosterone system has a major role in the impaired renal and systemic adaptation to dietary sodium removal in senescent rats. Sodium 167-173 renin Rattus norvegicus 56-61 8502656-1 1993 The objective of these experiments was to assess the possibility that the increase in tail skin temperature (TSK) accompanying administration of the beta-adrenergic agonist isoproterenol (ISO) was mediated by angiotensin II (AngII) as a result of stimulation of renin release by ISO. Isoproterenol 173-186 renin Rattus norvegicus 262-267 8502656-1 1993 The objective of these experiments was to assess the possibility that the increase in tail skin temperature (TSK) accompanying administration of the beta-adrenergic agonist isoproterenol (ISO) was mediated by angiotensin II (AngII) as a result of stimulation of renin release by ISO. Isoproterenol 188-191 renin Rattus norvegicus 262-267 8491500-10 1993 Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p < 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p < 0.01). Quercetin 30-39 renin Rattus norvegicus 79-84 8491500-10 1993 Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p < 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p < 0.01). Quercetin 200-209 renin Rattus norvegicus 79-84 7685451-4 1993 Acute angiotensin inhibition was studied at a dose of the converting enzyme inhibitor, enalapril, or the renin inhibitor, CP71362, that lowered the mean arterial pressure by 15 mm Hg in normal rats. CP 71362 122-129 renin Rattus norvegicus 105-110 8330801-5 1993 Carperitide tended to decrease isoproterenol-induced renin release from isolated rat kidney slices and elicited decreases in angiotensin II-induced aldosterone release from bovine zona glomerulosa cells. NPPA protein, human 0-11 renin Rattus norvegicus 53-58 8330801-5 1993 Carperitide tended to decrease isoproterenol-induced renin release from isolated rat kidney slices and elicited decreases in angiotensin II-induced aldosterone release from bovine zona glomerulosa cells. Isoproterenol 31-44 renin Rattus norvegicus 53-58 8476110-10 1993 Restoration of intrarenal hemodynamics to or toward normal with quinapril supports an important pathophysiological role of renin-angiotensin system in this CHF. Quinapril 64-73 renin Rattus norvegicus 123-128 8465813-5 1993 The activity of plasma renin (3.0 +/- 0.5 ng/mL/min on SP v 1.1 +/- 0.1 ng/mL/min on LP) was significantly (P < 0.02) lower on LP intake. sp 55-57 renin Rattus norvegicus 23-28 8465813-5 1993 The activity of plasma renin (3.0 +/- 0.5 ng/mL/min on SP v 1.1 +/- 0.1 ng/mL/min on LP) was significantly (P < 0.02) lower on LP intake. leucylproline 85-87 renin Rattus norvegicus 23-28 8465813-5 1993 The activity of plasma renin (3.0 +/- 0.5 ng/mL/min on SP v 1.1 +/- 0.1 ng/mL/min on LP) was significantly (P < 0.02) lower on LP intake. leucylproline 130-132 renin Rattus norvegicus 23-28 8465813-6 1993 In contrast, glomerular renin content (22.9 +/- 0.7 ng/micrograms protein on SP v 32.3 +/- 1.4 ng/micrograms protein on LP) was significantly (P < 0.01) higher on the LP diet. sp 77-79 renin Rattus norvegicus 24-29 8465813-6 1993 In contrast, glomerular renin content (22.9 +/- 0.7 ng/micrograms protein on SP v 32.3 +/- 1.4 ng/micrograms protein on LP) was significantly (P < 0.01) higher on the LP diet. leucylproline 120-122 renin Rattus norvegicus 24-29 8465813-6 1993 In contrast, glomerular renin content (22.9 +/- 0.7 ng/micrograms protein on SP v 32.3 +/- 1.4 ng/micrograms protein on LP) was significantly (P < 0.01) higher on the LP diet. leucylproline 170-172 renin Rattus norvegicus 24-29 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. sp 95-97 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. leucylproline 116-118 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. Arachidonic Acid 164-180 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. sp 210-212 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. leucylproline 231-233 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. Isoproterenol 254-267 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. sp 210-212 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. leucylproline 231-233 renin Rattus norvegicus 13-18 8465813-7 1993 Furthermore, renin secretion (ng/mL/h) from the isolated glomeruli at baseline (3.9 +/- 1.0 on SP v 12.5 +/- 3.0 on LP, P < 0.02), and following incubation with arachidonic acid 10(-5) mol/L (5.9 +/- 1.7 on SP v 19.6 +/- 3.1 on LP, P < 0.005), and isoproterenol 10(-3) mol/L (6.0 +/- 0.5 on SP v 17.3 +/- 3.3 on LP, P < 0.01) was significantly higher on the LP diet. leucylproline 231-233 renin Rattus norvegicus 13-18 8484898-2 1993 Alcohol also activates the renin-angiotensin system, but the mechanism is poorly understood and not related to sodium excretion. Alcohols 0-7 renin Rattus norvegicus 27-32 8484898-5 1993 Peripheral captopril alone enhanced fluid intake, which indicated that alcohol elevated renin secretion. Captopril 11-20 renin Rattus norvegicus 88-93 8484898-5 1993 Peripheral captopril alone enhanced fluid intake, which indicated that alcohol elevated renin secretion. Alcohols 71-78 renin Rattus norvegicus 88-93 8484898-6 1993 Ethanol-induced suppression of hepatic plasma protein secretion and the consequent fall in plasma colloid osmotic pressure apparently resulted in hypovolemia and renin secretion, which then produced thirst and salt appetite through an action of ANG II on the brain. Ethanol 0-7 renin Rattus norvegicus 162-167 8458646-8 1993 Aortic renin messenger RNA level was extremely low and not increased by nephrectomy or losartan pretreatment, although kidney renin messenger RNA level was increased by losartan pretreatment. Losartan 169-177 renin Rattus norvegicus 126-131 8384604-4 1993 The angiotensin converting enzyme inhibitor quinapril significantly inhibited the vasoconstrictions caused by either angiotensin I or tetradecapeptide renin substrate. Quinapril 44-53 renin Rattus norvegicus 151-156 8476112-3 1993 Renin mRNA was assessed by in situ hybridization to a 35S-labeled oligonucleotide complementary to rat renin mRNA. Sulfur-35 54-57 renin Rattus norvegicus 0-5 8473549-0 1993 Antihypertensive action of heparin: role of the renin-angiotensin aldosterone system and prostaglandins. Heparin 27-34 renin Rattus norvegicus 48-53 8476112-3 1993 Renin mRNA was assessed by in situ hybridization to a 35S-labeled oligonucleotide complementary to rat renin mRNA. Sulfur-35 54-57 renin Rattus norvegicus 103-108 8473549-8 1993 A significant (P < .001) increase in plasma renin activity was found in heparin-treated SHRs and NWRs; however, a corresponding elevation of plasma aldosterone level was noted only in heparin-treated NWR. Heparin 75-82 renin Rattus norvegicus 47-52 8476112-3 1993 Renin mRNA was assessed by in situ hybridization to a 35S-labeled oligonucleotide complementary to rat renin mRNA. Oligonucleotides 66-81 renin Rattus norvegicus 0-5 8479116-6 1993 Administration of nifedipine was associated with a decline in systemic pressure, however, plasma renin levels increased, causing efferent arteriolar vasoconstriction and persistence of glomerular hypertension. Nifedipine 18-28 renin Rattus norvegicus 97-102 8481348-5 1993 Insulin and insulin-like growth factor I are also renin secretagogues in vitro However in a diabetic model (streptozotocin rat), there is resistance to both agonists as well as enhanced feedback suppression to angiotensin. Streptozocin 108-122 renin Rattus norvegicus 50-55 8386093-5 1993 Lisinopril attenuated the increase in plasma norepinephrine, and increased plasma renin activity (both P < 0.05). Lisinopril 0-10 renin Rattus norvegicus 82-87 8456103-0 1993 Effect of Losartan, a nonpeptide angiotensin II receptor antagonist, on drinking behavior and renal actions of centrally administered renin. Losartan 10-18 renin Rattus norvegicus 134-139 8456103-2 1993 Intracerebroventricular administration of renin reduces urine volume and increases sodium excretion and water intake in conscious, male, hydrated rats. Sodium 83-89 renin Rattus norvegicus 42-47 8456103-2 1993 Intracerebroventricular administration of renin reduces urine volume and increases sodium excretion and water intake in conscious, male, hydrated rats. Water 104-109 renin Rattus norvegicus 42-47 8456103-3 1993 Losartan (3 or 10 mg/kg, sc) reduced the increased sodium excretion and totally inhibited the antidiuretic action induced by intracerebroventricular renin. Losartan 0-8 renin Rattus norvegicus 149-154 8456103-5 1993 Peripheral and central administration of the AT1 receptor blocker significantly lengthened the onset of drinking behavior and reduced the cumulative water intake observed after intracerebroventricular injection of renin. Water 149-154 renin Rattus norvegicus 214-219 8385532-14 1993 By contrast, the high urinary vasopressin excretion and suppressed plasma renin activity found in DOC-treated rats were not altered by Hoe 140. Desoxycorticosterone 98-101 renin Rattus norvegicus 74-79 8457002-2 1993 First, we looked for manifestations of altered renin-angiotensin-aldosterone system activity during the progression of calcium deficiency. Calcium 119-126 renin Rattus norvegicus 47-52 8457013-2 1993 Renal renin mRNA was identified by hybridization with a 32P-labeled full length rat renin cDNA. Phosphorus-32 56-59 renin Rattus norvegicus 6-11 8457013-2 1993 Renal renin mRNA was identified by hybridization with a 32P-labeled full length rat renin cDNA. Phosphorus-32 56-59 renin Rattus norvegicus 84-89 8383697-2 1993 We found that stimulation of EDRF release by acetylcholine (1 mumol/liter) increased mean perfusate flow rates from 15.0 +/- 0.5 to 18.0 +/- 0.5 ml/min per g and average renin secretion rates from 3.5 +/- 0.5 to 16.0 +/- 2.0 ng angiotensin I/h per min per g at a perfusion pressure of 100 mmHg (mean +/- SEM, n = 6). Acetylcholine 45-58 renin Rattus norvegicus 170-175 8467569-0 1993 The angiotensin-converting enzyme inhibitor, perindopril, prevents cardiac hypertrophy in low-renin hypertensive rats. Perindopril 45-56 renin Rattus norvegicus 94-99 8383701-0 1993 Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium. Cyclic AMP 93-97 renin Rattus norvegicus 18-23 8383701-0 1993 Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium. Calcium 119-126 renin Rattus norvegicus 18-23 8383701-6 1993 TGR(mREN2)27 adrenal cells may serve as a new tool to investigate the regulation and processing of Ren-2d-derived renin and its significance in hypertension and steroid metabolism. Steroids 161-168 renin Rattus norvegicus 114-119 8383701-7 1993 Adrenal renin in TGR(mREN2)27 is stimulated by 8-bromo-cAMP (8-Br-cAMP), angiotensin II (ANGII), and calcium. 8-Bromo Cyclic Adenosine Monophosphate 47-59 renin Rattus norvegicus 8-13 8383701-7 1993 Adrenal renin in TGR(mREN2)27 is stimulated by 8-bromo-cAMP (8-Br-cAMP), angiotensin II (ANGII), and calcium. 8-Bromo Cyclic Adenosine Monophosphate 61-70 renin Rattus norvegicus 8-13 8383701-8 1993 8-Br-cAMP significantly stimulates active renin and prorenin release, as well as Ren-2d mRNA. 8-Bromo Cyclic Adenosine Monophosphate 0-9 renin Rattus norvegicus 42-47 8383701-9 1993 Interestingly, within 60 min 8-Br-cAMP, ANGII, and calcimycin stimulate active renin, but not prorenin release. 8-Bromo Cyclic Adenosine Monophosphate 29-38 renin Rattus norvegicus 79-84 8383701-9 1993 Interestingly, within 60 min 8-Br-cAMP, ANGII, and calcimycin stimulate active renin, but not prorenin release. Calcimycin 51-61 renin Rattus norvegicus 79-84 7680667-6 1993 Cellular renin content in cultured proximal tubule cells was increased by incubation with 10(-5) M isoproterenol and 10(-5) M forskolin by 150 and 110%, respectively. Isoproterenol 99-112 renin Rattus norvegicus 9-14 7680667-6 1993 Cellular renin content in cultured proximal tubule cells was increased by incubation with 10(-5) M isoproterenol and 10(-5) M forskolin by 150 and 110%, respectively. Colforsin 126-135 renin Rattus norvegicus 9-14 7680667-9 1993 However, in tubules from rats administered the angiotensinogen-converting-enzyme inhibitor, enalapril, renin was easily detected in the S2 segment of the proximal tubule. Enalapril 92-101 renin Rattus norvegicus 103-108 7680667-10 1993 We postulate the existence of a local renin-angiotensin system that enables the proximal tubule to generate angiotensin II, thereby providing an autocrine system that could locally modulate NaHCO3 and NaCl absorption. Sodium Bicarbonate 190-196 renin Rattus norvegicus 38-43 7680667-10 1993 We postulate the existence of a local renin-angiotensin system that enables the proximal tubule to generate angiotensin II, thereby providing an autocrine system that could locally modulate NaHCO3 and NaCl absorption. Sodium Chloride 201-205 renin Rattus norvegicus 38-43 8383697-5 1993 The rise of renin secretion in response to a reduction of the renal artery pressure was markedly attenuated with inhibitors of EDRF formation such as NG-nitro-L-arginine (100 mumol/liter) and related compounds. Nitroarginine 150-169 renin Rattus norvegicus 12-17 8383697-6 1993 During inhibition of EDRF formation, addition of sodium nitroprusside (10 mumol/liter) increased mean perfusate flow rates from 12.0 +/- 0.5 to 23.0 +/- 2.0 ml/min per g and average renin secretion rates from 2.0 +/- 0.5 to 18.0 +/- 1.5 ng AngI/h per min per g at 100 mmHg (n = 5). Nitroprusside 49-69 renin Rattus norvegicus 182-187 8387081-7 1993 In sharp contrast, atrial extracts from sodium-depleted enalapril-treated rats displayed a pronounced band of hybridization, corresponding in size to that expected for renin mRNA. Sodium 40-46 renin Rattus norvegicus 168-173 8467569-11 1993 These results demonstrate that perindopril may be able to prevent LV hypertrophy even in low-renin hypertension, which was not mediated by a reduction of blood pressure or suppression of the circulating and cardiac renin-angiotensin systems. Perindopril 31-42 renin Rattus norvegicus 93-98 8387081-7 1993 In sharp contrast, atrial extracts from sodium-depleted enalapril-treated rats displayed a pronounced band of hybridization, corresponding in size to that expected for renin mRNA. Enalapril 56-65 renin Rattus norvegicus 168-173 8387081-9 1993 CONCLUSION: The present PCR study has shown that in the normal sodium-replete rat, atrial tissue has only very low renin gene expression, but that after a low-sodium diet + treatment with enalapril, expression is switched on in atrium. Enalapril 188-197 renin Rattus norvegicus 115-120 8455360-1 1993 To determine whether Cyclosporine A (CsA) alters the intrarenal expression of the renin and type 1 angiotensin II receptor genes, male adult Sprague-Dawley rats were given 25 mg/kg/day CsA s.c. for three weeks (CsA, N = 20) and were compared to pair-fed vehicle treated rats (Con, N = 20). Cyclosporine 21-35 renin Rattus norvegicus 82-87 8455360-1 1993 To determine whether Cyclosporine A (CsA) alters the intrarenal expression of the renin and type 1 angiotensin II receptor genes, male adult Sprague-Dawley rats were given 25 mg/kg/day CsA s.c. for three weeks (CsA, N = 20) and were compared to pair-fed vehicle treated rats (Con, N = 20). Cyclosporine 37-40 renin Rattus norvegicus 82-87 8455360-4 1993 The percentage of juxtaglomerular apparatuses containing renin was higher in the CsA (84 +/- 5.5%) than in the Con (61 +/- 6.7%) group, (P < 0.05). Cyclosporine 81-84 renin Rattus norvegicus 57-62 8391664-8 1993 Previous studies have demonstrated that ibotenic acid lesions in the central amygdala reduce corticosterone and renin response to conditioned stress. Ibotenic Acid 40-53 renin Rattus norvegicus 112-117 8474102-2 1993 Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-72517). 2s)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-l-alanine amide 62-154 renin Rattus norvegicus 45-50 8474102-2 1993 Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-72517). CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE 158-219 renin Rattus norvegicus 45-50 8452566-10 1993 The absence of oxygen or a decreased cellular ATP content blocked the hepatocellular uptake of the renin inhibitor. Oxygen 15-21 renin Rattus norvegicus 99-104 8452566-10 1993 The absence of oxygen or a decreased cellular ATP content blocked the hepatocellular uptake of the renin inhibitor. Adenosine Triphosphate 46-49 renin Rattus norvegicus 99-104 8452567-8 1993 In contrast, the uncharged compound ouabain (Ki = 200 microM) and the bivalent organic cation d-tubocurarine (Ki = 370 microM) competitively inhibited the uptake of the renin inhibitor. Ouabain 36-43 renin Rattus norvegicus 169-174 8452567-8 1993 In contrast, the uncharged compound ouabain (Ki = 200 microM) and the bivalent organic cation d-tubocurarine (Ki = 370 microM) competitively inhibited the uptake of the renin inhibitor. Tubocurarine 94-108 renin Rattus norvegicus 169-174 8498964-6 1993 Both effects were sensitive to captopril (CAS 62571-86-2) and to the renin inhibitor H-142 (H-Pro-His-Pro-Phe-His-Leu-Val-Ile-His-OH). h-pro-his 92-101 renin Rattus norvegicus 69-74 8498964-6 1993 Both effects were sensitive to captopril (CAS 62571-86-2) and to the renin inhibitor H-142 (H-Pro-His-Pro-Phe-His-Leu-Val-Ile-His-OH). Histidine 98-101 renin Rattus norvegicus 69-74 8425700-5 1993 In addition, octreotide treatment significantly reduced portal pressure as well as glucagon levels and plasma renin activity. Octreotide 13-23 renin Rattus norvegicus 110-115 8223156-8 1993 It is implied that the renin-angiotensin system may be involved in the pathogenesis of diabetic cardiomyopathy, since captopril can improve and reverse the cardiomyopathy of diabetic rats. Captopril 118-127 renin Rattus norvegicus 23-28 8381736-6 1993 Plasma renin activity in the spirapril-treated group was significantly elevated compared with that in the vehicle group at any time (P < 0.01). spirapril 29-38 renin Rattus norvegicus 7-12 8385523-0 1993 Renin release induced by losartan (DuP 753), an angiotensin II receptor antagonist. Losartan 25-33 renin Rattus norvegicus 0-5 8385523-0 1993 Renin release induced by losartan (DuP 753), an angiotensin II receptor antagonist. Losartan 35-42 renin Rattus norvegicus 0-5 8474696-0 1993 Reduced increase in plasma renin activity on water-deprivation in blind hereditary microphthalmic rats. Water 45-50 renin Rattus norvegicus 27-32 8381736-8 1993 The ratio of renal renin mRNA to beta-actin mRNA in the spirapril-treated group was higher than that in the control group (P < 0.01). spirapril 56-65 renin Rattus norvegicus 19-24 8385523-6 1993 The nonselective beta-blocker propranolol and the beta 1 selective blocker atenolol attenuated losartan-induced renin release approximately 70 and 80% respectively without altering blood pressure. Propranolol 30-41 renin Rattus norvegicus 112-117 8385523-6 1993 The nonselective beta-blocker propranolol and the beta 1 selective blocker atenolol attenuated losartan-induced renin release approximately 70 and 80% respectively without altering blood pressure. Atenolol 75-83 renin Rattus norvegicus 112-117 8381736-10 1993 At 28 days, plasma renin activity in the spirapril-treated group was significantly elevated compared with that at 14 days (P < 0.05). spirapril 41-50 renin Rattus norvegicus 19-24 8385523-6 1993 The nonselective beta-blocker propranolol and the beta 1 selective blocker atenolol attenuated losartan-induced renin release approximately 70 and 80% respectively without altering blood pressure. Losartan 95-103 renin Rattus norvegicus 112-117 8382128-9 1993 In both glomeruli and juxtaglomerular cells bovine [Nle8,18,Tyr34]parathyroid hormone-(1-34)amide effectively and repeatedly stimulated renin release. Amides 92-97 renin Rattus norvegicus 136-141 8385523-8 1993 The findings suggest that losartan interferes with the ability of angiotensin II to suppress that renin release which is mediated by sympathetic nerve activity. Losartan 26-34 renin Rattus norvegicus 98-103 8382128-16 1993 These results provide further support for the role of parathyroid hormone as a direct mediator of renin secretion; moreover, the renin-stimulating action of parathyroid hormone may be mediated through the inhibition of calcium influx. Calcium 219-226 renin Rattus norvegicus 129-134 8445983-0 1993 Effect of caffeine treatment on plasma renin activity and angiotensin I concentrations in rats on a low sodium diet. Caffeine 10-18 renin Rattus norvegicus 39-44 8095217-0 1993 Hepatic elimination in the rat of ditekiren (U-71038), a renin inhibitor pseudohexapeptide. ditekiren 34-43 renin Rattus norvegicus 57-62 8095217-0 1993 Hepatic elimination in the rat of ditekiren (U-71038), a renin inhibitor pseudohexapeptide. ditekiren 45-52 renin Rattus norvegicus 57-62 8095217-4 1993 Accordingly, the disposition of the renin inhibitor ditekiren--a pseudohexapeptide used as a model agent--was investigated in the isolated perfused rat liver preparation. ditekiren 52-61 renin Rattus norvegicus 36-41 8382237-1 1993 OBJECTIVE: To study the effects of renin-angiotensin system blockade by a novel non-peptide angiotensin II receptor antagonist, losartan, on development of hypertension and acceleration of end-organ damage in salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP). Losartan 128-136 renin Rattus norvegicus 35-40 8445983-2 1993 This observation suggests that endogenous adenosine plays a physiologically significant role in restraining renin release. Adenosine 42-51 renin Rattus norvegicus 108-113 7692205-0 1993 BAY K 8644 inhibits renin secretion in isolated perfused rat kidneys. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 0-10 renin Rattus norvegicus 20-25 8445983-3 1993 However, it is unclear whether chronic blockade of adenosine receptors would cause a rise of renin activity since tolerance to adenosine blockade is known to develop quickly. Adenosine 51-60 renin Rattus norvegicus 93-98 7692205-5 1993 Therefore, BAY K 8644 inhibits renin secretion at constant perfusion pressure and blunts the stimulatory effect on renin secretion of decreases in renal perfusion pressure. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 11-21 renin Rattus norvegicus 31-36 8445983-4 1993 An earlier study partially addressed this question by showing that chronic blockade of adenosine receptors with caffeine exacerbated both the rise of plasma renin activity and the decline of renal function in 2-kidney-1-clip (2K1C) renovascular hypertensive rats. Caffeine 112-120 renin Rattus norvegicus 157-162 7692205-5 1993 Therefore, BAY K 8644 inhibits renin secretion at constant perfusion pressure and blunts the stimulatory effect on renin secretion of decreases in renal perfusion pressure. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 11-21 renin Rattus norvegicus 115-120 8445983-6 1993 The purpose of this study was to reexamine the effect of chronic caffeine consumption on plasma renin activity and angiotensin I levels in animals in another high-renin model, i.e., the low sodium diet. Caffeine 65-73 renin Rattus norvegicus 96-101 8445983-11 1993 The results of this study show that chronic blockade of adenosine receptors with 0.1% caffeine water increases plasma renin activity and angiotensin I concentration before and throughout the three weeks when animals were on the low sodium diet. caffeine water 86-100 renin Rattus norvegicus 118-123 8445983-12 1993 The results of this study suggest that the inhibitory role of adenosine on renin release is a general physiological process, rather than a special situation applicable only to the 2K1C model. Adenosine 62-71 renin Rattus norvegicus 75-80 8446257-1 1993 In order to determine the activity of the renin-angiotensin system in the nephrotic syndrome, the plasma concentration of angiotensinogen was measured in rats with puromycin aminonucleoside (PA)-induced nephrosis using two different methods: a direct radioimmunoassay, which measures both angiotensinogen and des-angiotensin I-angiotensinogen, and an indirect assay, which measures angiotensin I liberated from angiotensinogen by excess renin. Puromycin Aminonucleoside 191-193 renin Rattus norvegicus 42-47 8302420-5 1993 Caffeine exacerbated the development of 2K1C hypertension in association with a higher plasma renin concentration (PRC). Caffeine 0-8 renin Rattus norvegicus 94-99 8446257-5 1993 The difference between the concentrations of plasma angiotensinogen determined by these methods increased before and during the early phase of PA-induced nephrosis, suggesting the increased consumption of angiotensinogen by renin during this period. Puromycin Aminonucleoside 143-145 renin Rattus norvegicus 224-229 8302420-9 1993 These results suggest that caffeine specifically exacerbates 2K1C hypertension through increasing renin release whereas it ameliorates DOCA-salt hypertension possibly through increasing renal excretion. Caffeine 27-35 renin Rattus norvegicus 98-103 8446257-7 1993 These results indicate that the renin-angiotensin system is activated before the appearance of PA-induced nephrotic syndrome. Puromycin Aminonucleoside 95-97 renin Rattus norvegicus 32-37 1481890-2 1992 Adenosine produced and released within the kidney is thought to participate in the metabolic regulation of glomerular filtration (tubuloglomerular feedback), as well as in regulating renal excretory function and renin secretion. Adenosine 0-9 renin Rattus norvegicus 212-217 8234540-0 1993 Effect of adenosine blockade on plasma renin activity and catecholamines. Adenosine 10-19 renin Rattus norvegicus 39-44 8234540-1 1993 We explored the hypothesis that chronic blockage of adenosine (Ado) receptors might augment the renin response to sodium restriction. Sodium 114-120 renin Rattus norvegicus 96-101 8234540-8 1993 Our data showed that the inhibitory effect of Ado on renin activity and blood pressure in salt restricted rats was attenuated by caffeine at the first week but not at six weeks after institution of the low sodium diet. Caffeine 129-137 renin Rattus norvegicus 53-58 8434183-3 1993 In the adult kidney, renin is principally localized to jg cells of the distal afferent arteriole, where release is stimulated by increases in intracellular cAMP and inhibited by increases in cytosolic calcium. Cyclic AMP 156-160 renin Rattus norvegicus 21-26 8434183-3 1993 In the adult kidney, renin is principally localized to jg cells of the distal afferent arteriole, where release is stimulated by increases in intracellular cAMP and inhibited by increases in cytosolic calcium. Calcium 201-208 renin Rattus norvegicus 21-26 8434183-4 1993 Four distinct stimuli mediating renin release are (1) NaCl sensed at the macula densa, (2) the sympathetic nervous system, (3) humoral factors, with Ang II, vasopressin, endothelin, and adenosine inhibiting renin release, and (4) changes in intrarenal blood pressure. Sodium Chloride 54-58 renin Rattus norvegicus 32-37 8434183-5 1993 Alterations in renal renin gene expression have been reported in pathophysiological states, such as salt depletion, diabetes mellitus, ureteral obstruction, Bartter"s syndrome, and with high protein feeding. Salts 100-104 renin Rattus norvegicus 21-26 1481890-9 1992 The distribution of A1 and A2a adenosine receptor mRNAs within the rat kidney supports previously postulated roles for adenosine in the regulation of renal hemodynamics, excretory function, and renin secretion. Adenosine 31-40 renin Rattus norvegicus 194-199 1446631-0 1992 Effects of long-term infusions of dopa and carbidopa on renin and steroid secretion in the rat. Dihydroxyphenylalanine 34-38 renin Rattus norvegicus 56-61 1307720-0 1992 Subcellular distribution of differently glycosylated forms of active and inactive renin in rat kidney: effect of sodium depletion and captopril treatment. Captopril 134-143 renin Rattus norvegicus 82-87 1307720-3 1992 After a long-term stimulation of renin synthesis and secretion by sodium depletion and captopril treatment the relative proportion of active renins I and II in granules significantly increased, while that of active renin III decreased. Sodium 66-72 renin Rattus norvegicus 33-38 1307720-3 1992 After a long-term stimulation of renin synthesis and secretion by sodium depletion and captopril treatment the relative proportion of active renins I and II in granules significantly increased, while that of active renin III decreased. Captopril 87-96 renin Rattus norvegicus 33-38 1307720-3 1992 After a long-term stimulation of renin synthesis and secretion by sodium depletion and captopril treatment the relative proportion of active renins I and II in granules significantly increased, while that of active renin III decreased. Captopril 87-96 renin Rattus norvegicus 141-146 1446631-0 1992 Effects of long-term infusions of dopa and carbidopa on renin and steroid secretion in the rat. Carbidopa 43-52 renin Rattus norvegicus 56-61 1443118-5 1992 Three days of angiotensin-converting enzyme inhibition (10 mg.kg-1 x day-1 quinapril in drinking water, n = 8) significantly decreased MAP (P < 0.05) and increased both mean plasma renin concentration (P < 0.05) and renal renin mRNA levels (P < 0.005). Quinapril 75-84 renin Rattus norvegicus 184-189 1333446-4 1992 The effects of adrenocorticotropic hormone or potassium on adrenal zona glomerulosa cell renin activity and renin mRNA content were compared with the activity and content of control cells. Potassium 46-55 renin Rattus norvegicus 89-94 1333446-5 1992 After 1 and 4 hours of stimulation by adrenocorticotropic hormone or potassium, total renin in the medium increased slightly; at the same time, the percent change in the amount of renin mRNA was 281% and 291%, respectively, in the adrenocorticotropic hormone-stimulated group and 218% and 348%, respectively, in the potassium-stimulated group. Potassium 69-78 renin Rattus norvegicus 86-91 1333446-6 1992 Twenty-four hours after adrenocorticotropic hormone or potassium stimulation, total renin in the medium increased significantly, by 689% and 220%, respectively; percent change in the renin mRNA content was 754% and 278%, respectively. Potassium 55-64 renin Rattus norvegicus 84-89 1333446-6 1992 Twenty-four hours after adrenocorticotropic hormone or potassium stimulation, total renin in the medium increased significantly, by 689% and 220%, respectively; percent change in the renin mRNA content was 754% and 278%, respectively. Potassium 55-64 renin Rattus norvegicus 183-188 1333446-7 1992 These results demonstrate that adrenocorticotropic hormone and potassium increased the activity of adrenal renin through an increase in the level of renin mRNA. Potassium 63-72 renin Rattus norvegicus 107-112 1333446-7 1992 These results demonstrate that adrenocorticotropic hormone and potassium increased the activity of adrenal renin through an increase in the level of renin mRNA. Potassium 63-72 renin Rattus norvegicus 149-154 1291822-4 1992 For instance, a markedly low luminance appeared on the Du channel in animals with experimental syndrome of Yang deficiency induced by hydrocortisone; while in animals with experimental syndrome of blood deficiency caused by bleeding, an apparently low luminance occurred on the Ren channel. Hydrocortisone 134-148 renin Rattus norvegicus 278-281 1443118-5 1992 Three days of angiotensin-converting enzyme inhibition (10 mg.kg-1 x day-1 quinapril in drinking water, n = 8) significantly decreased MAP (P < 0.05) and increased both mean plasma renin concentration (P < 0.05) and renal renin mRNA levels (P < 0.005). Quinapril 75-84 renin Rattus norvegicus 228-233 1482638-0 1992 Plasma renin activity as a marker for growth failure due to sodium deficiency in young rats. Sodium 60-66 renin Rattus norvegicus 7-12 1330361-0 1992 Differential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure. Captopril 24-33 renin Rattus norvegicus 58-63 1330361-0 1992 Differential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure. Enalapril 38-47 renin Rattus norvegicus 58-63 1396339-10 1992 Renin activity in the adrenal homogenate, medium, and plasma from TGR rats was completely inhibited by the renin inhibitor (CP 71362; 1 microM), but only slightly inhibited (12.3 +/- 3%) by a monoclonal antibody that inhibits renin activity from S-D rat tissues by 79.2 +/- 2.5%, suggesting that renin in the plasma and adrenal glands from TGR appears to derive primarily from mouse renin. CP 71362 124-132 renin Rattus norvegicus 0-5 1458311-4 1992 Previous studies suggest that serotonergic neurons, projecting to the hypothalamus, mediate the effect of p-chloroamphetamine on renin secretion. p-Chloroamphetamine 106-125 renin Rattus norvegicus 129-134 1458311-8 1992 The renin response to both RU 24969 and p-chloroamphetamine was significantly reduced in rats with histologically verified paraventricular lesions compared to vehicle treated controls. Ruthenium 27-29 renin Rattus norvegicus 4-9 1458311-8 1992 The renin response to both RU 24969 and p-chloroamphetamine was significantly reduced in rats with histologically verified paraventricular lesions compared to vehicle treated controls. p-Chloroamphetamine 40-59 renin Rattus norvegicus 4-9 1458311-9 1992 In contrast, the renin response to p-chloroamphetamine remained unchanged in rats with either dorsomedial or ventromedial hypothalamic lesions. p-Chloroamphetamine 35-54 renin Rattus norvegicus 17-22 1415738-0 1992 Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE. (r)-12-hete 64-75 renin Rattus norvegicus 14-19 1415738-1 1992 The arachidonic acid metabolite 12-hydroxyeicosatetraenoic acid (12-HETE) inhibits renin secretion both in vivo and in vitro, but the enzymatic origin of the 12-HETE responsible for renin inhibition is unknown. Arachidonic Acid 4-20 renin Rattus norvegicus 83-88 1415738-1 1992 The arachidonic acid metabolite 12-hydroxyeicosatetraenoic acid (12-HETE) inhibits renin secretion both in vivo and in vitro, but the enzymatic origin of the 12-HETE responsible for renin inhibition is unknown. Arachidonic Acid 4-20 renin Rattus norvegicus 182-187 1415738-1 1992 The arachidonic acid metabolite 12-hydroxyeicosatetraenoic acid (12-HETE) inhibits renin secretion both in vivo and in vitro, but the enzymatic origin of the 12-HETE responsible for renin inhibition is unknown. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 32-63 renin Rattus norvegicus 83-88 1415738-1 1992 The arachidonic acid metabolite 12-hydroxyeicosatetraenoic acid (12-HETE) inhibits renin secretion both in vivo and in vitro, but the enzymatic origin of the 12-HETE responsible for renin inhibition is unknown. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 65-72 renin Rattus norvegicus 83-88 1415738-1 1992 The arachidonic acid metabolite 12-hydroxyeicosatetraenoic acid (12-HETE) inhibits renin secretion both in vivo and in vitro, but the enzymatic origin of the 12-HETE responsible for renin inhibition is unknown. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 65-72 renin Rattus norvegicus 182-187 1415738-1 1992 The arachidonic acid metabolite 12-hydroxyeicosatetraenoic acid (12-HETE) inhibits renin secretion both in vivo and in vitro, but the enzymatic origin of the 12-HETE responsible for renin inhibition is unknown. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 158-165 renin Rattus norvegicus 182-187 1415738-4 1992 (R)-12-HETE reduced basal renin release by 28 +/- 4% to 49 +/- 5% at concentrations of 10(-9) to 10(-7) M (P < 0.05 to 0.01). (r)-12-hete 0-11 renin Rattus norvegicus 26-31 1415738-6 1992 (R)-12-HETE also blunted isoproterenol-stimulated renin secretion (P < 0.05) at a concentration of 10(-6) M. 20-HETE, another cytochrome P-450 product, did not exert a significant effect on renin release. (r)-12-hete 0-11 renin Rattus norvegicus 50-55 1415738-6 1992 (R)-12-HETE also blunted isoproterenol-stimulated renin secretion (P < 0.05) at a concentration of 10(-6) M. 20-HETE, another cytochrome P-450 product, did not exert a significant effect on renin release. (r)-12-hete 0-11 renin Rattus norvegicus 193-198 1415738-6 1992 (R)-12-HETE also blunted isoproterenol-stimulated renin secretion (P < 0.05) at a concentration of 10(-6) M. 20-HETE, another cytochrome P-450 product, did not exert a significant effect on renin release. Isoproterenol 25-38 renin Rattus norvegicus 50-55 1415738-6 1992 (R)-12-HETE also blunted isoproterenol-stimulated renin secretion (P < 0.05) at a concentration of 10(-6) M. 20-HETE, another cytochrome P-450 product, did not exert a significant effect on renin release. Isoproterenol 25-38 renin Rattus norvegicus 193-198 1415738-8 1992 Only (R)-12-HETE directly inhibits in vitro renin release. (r)-12-hete 5-16 renin Rattus norvegicus 44-49 1396304-1 1992 Angiotensin-converting enzyme inhibition with enalapril increases the number of glomeruli with juxtaglomerular cells and the number of cells in the afferent arteriole that express the renin gene and contain renin. Enalapril 46-55 renin Rattus norvegicus 184-189 1396304-1 1992 Angiotensin-converting enzyme inhibition with enalapril increases the number of glomeruli with juxtaglomerular cells and the number of cells in the afferent arteriole that express the renin gene and contain renin. Enalapril 46-55 renin Rattus norvegicus 207-212 1396304-3 1992 Sodium depletion also has been shown to increase renal renin messenger RNA levels. Sodium 0-6 renin Rattus norvegicus 55-60 1396304-6 1992 Enalapril treatment increased the number of renin secreting cells by approximately 10-fold (P < 0.05). Enalapril 0-9 renin Rattus norvegicus 44-49 1396304-8 1992 At physiological (2.5 mM) extracellular calcium concentration, the amount of renin secreted per cell was approximately 2-fold greater (P < 0.05) when cells from enalapril-treated rats were compared to controls and sodium depletion increased both the number of renin-secreting cells and the amount of renin secreted by approximately 35% (P < 0.05). Calcium 40-47 renin Rattus norvegicus 77-82 1396304-8 1992 At physiological (2.5 mM) extracellular calcium concentration, the amount of renin secreted per cell was approximately 2-fold greater (P < 0.05) when cells from enalapril-treated rats were compared to controls and sodium depletion increased both the number of renin-secreting cells and the amount of renin secreted by approximately 35% (P < 0.05). Enalapril 164-173 renin Rattus norvegicus 77-82 1396304-8 1992 At physiological (2.5 mM) extracellular calcium concentration, the amount of renin secreted per cell was approximately 2-fold greater (P < 0.05) when cells from enalapril-treated rats were compared to controls and sodium depletion increased both the number of renin-secreting cells and the amount of renin secreted by approximately 35% (P < 0.05). Enalapril 164-173 renin Rattus norvegicus 263-268 1396304-8 1992 At physiological (2.5 mM) extracellular calcium concentration, the amount of renin secreted per cell was approximately 2-fold greater (P < 0.05) when cells from enalapril-treated rats were compared to controls and sodium depletion increased both the number of renin-secreting cells and the amount of renin secreted by approximately 35% (P < 0.05). Enalapril 164-173 renin Rattus norvegicus 263-268 1396304-8 1992 At physiological (2.5 mM) extracellular calcium concentration, the amount of renin secreted per cell was approximately 2-fold greater (P < 0.05) when cells from enalapril-treated rats were compared to controls and sodium depletion increased both the number of renin-secreting cells and the amount of renin secreted by approximately 35% (P < 0.05). Sodium 217-223 renin Rattus norvegicus 77-82 1396304-9 1992 Angiotensin II (AII) inhibited the number of cells secreting renin in cortical cells prepared from enalapril-treated and control rats. Enalapril 99-108 renin Rattus norvegicus 61-66 1396339-11 1992 In conclusion, the TGR (mRen-2)27 rats have higher than normal levels of adrenal renin, and the cultured cells show an exaggerated renin response to ACTH and potassium. Potassium 158-167 renin Rattus norvegicus 131-136 1396339-10 1992 Renin activity in the adrenal homogenate, medium, and plasma from TGR rats was completely inhibited by the renin inhibitor (CP 71362; 1 microM), but only slightly inhibited (12.3 +/- 3%) by a monoclonal antibody that inhibits renin activity from S-D rat tissues by 79.2 +/- 2.5%, suggesting that renin in the plasma and adrenal glands from TGR appears to derive primarily from mouse renin. CP 71362 124-132 renin Rattus norvegicus 107-112 1396304-11 1992 In contrast, sodium depletion increased renin secretion equally by both mechanisms. Sodium 13-19 renin Rattus norvegicus 40-45 1359439-13 1992 Ipsapirone potentiated the effect of DOI on the concentration of renin in plasma but this effect was not observed in 8-OH-DPAT- and buspirone-pretreated rats. ipsapirone 0-10 renin Rattus norvegicus 65-70 1401084-10 1992 Enalapril treatment in HF rats increased renin mRNA level (2.5-fold, P < 0.005), KRC (5.6-fold, P = 0.005), and PRC (15.5-fold, P < 0.005). Enalapril 0-9 renin Rattus norvegicus 41-46 1420565-7 1992 In 2KGH rats treated with captopril, the number of renin immunoreactive JG cells in the clipped kidneys increased, whereas that of AII immunoreactive JG cells in the bilateral kidney decreased. Captopril 26-35 renin Rattus norvegicus 51-56 1420565-8 1992 When captopril was administered to SHR, the number of renin immunoreactive JG cells in the bilateral kidney increased, whereas that of AII immunoreactive JG cells in the bilateral kidney decreased. Captopril 5-14 renin Rattus norvegicus 54-59 1420565-10 1992 The increase of renin immunoreactive JG cells in 2KGH rats and SHR treated with captopril was probably due to the removal of negative feedback inhibition of AII on JG cells. Captopril 80-89 renin Rattus norvegicus 16-21 1328376-1 1992 OBJECTIVE: To study the effects of blockade of the renin-angiotensin system upon the development of hypertension, end-organ damage and mortality in Dahl salt-sensitive (DSS) rats using an angiotensin II receptor antagonist, losartan. dahl salt 148-157 renin Rattus norvegicus 51-56 1415565-12 1992 Enalapril treatment (7 days; n = 5) increased the number of plaque-forming cells to 22 +/- 2 for ANG I (P less than 0.0005) and to 39 +/- 7 for renin (P less than 0.001). Enalapril 0-9 renin Rattus norvegicus 144-149 1328376-11 1992 CONCLUSIONS: These results indicate that whereas the rise in blood pressure is dependent upon sodium loading, morbidity and mortality in salt-loaded DSS rats are associated with activation of the renin-angiotensin system and are only partially related to blood pressure. Salts 137-141 renin Rattus norvegicus 196-201 1510718-12 1992 It is suggested that Cd may induce liver ODC through the increase in angiotensin II following stimulation of renin by the metal. Metals 122-127 renin Rattus norvegicus 109-114 1328376-11 1992 CONCLUSIONS: These results indicate that whereas the rise in blood pressure is dependent upon sodium loading, morbidity and mortality in salt-loaded DSS rats are associated with activation of the renin-angiotensin system and are only partially related to blood pressure. dss 149-152 renin Rattus norvegicus 196-201 1510718-8 1992 Cd caused an increase in renin activity starting minutes after its injection. Cadmium 0-2 renin Rattus norvegicus 25-30 1383315-4 1992 The potent and specific rat renin inhibitor CH-732 was used. ch-732 44-50 renin Rattus norvegicus 28-33 1438875-2 1992 Prostaglandin E2 (PGE2) and prostacyclin (PGI2) are promoters of natriuresis and renin release. Dinoprostone 18-22 renin Rattus norvegicus 81-86 1510122-1 1992 Endothelium-derived relaxing factor (EDRF), through its inhibitory second messenger guanosine 3",5"-cyclic monophosphate (cGMP), inhibits renin release in vitro. Cyclic GMP 84-120 renin Rattus norvegicus 138-143 1510122-1 1992 Endothelium-derived relaxing factor (EDRF), through its inhibitory second messenger guanosine 3",5"-cyclic monophosphate (cGMP), inhibits renin release in vitro. Cyclic GMP 122-126 renin Rattus norvegicus 138-143 1438875-2 1992 Prostaglandin E2 (PGE2) and prostacyclin (PGI2) are promoters of natriuresis and renin release. Dinoprostone 0-16 renin Rattus norvegicus 81-86 1510718-12 1992 It is suggested that Cd may induce liver ODC through the increase in angiotensin II following stimulation of renin by the metal. Cadmium 21-23 renin Rattus norvegicus 109-114 1324618-5 1992 Isoproterenol augmented the renin response at 50 mmHg in all three strains, with the greatest effect occurring in the Sprague-Dawley rats. Isoproterenol 0-13 renin Rattus norvegicus 28-33 1324618-7 1992 Propranolol had no effect in the SHR and WKY animals, but significantly reduced the renin response at 50 mmHg in the Sprague-Dawley rats. Propranolol 0-11 renin Rattus norvegicus 84-89 1325502-3 1992 Effects of salt, captopril and clonidine upon renin gene expression were also investigated. Clonidine 31-40 renin Rattus norvegicus 46-51 1325502-6 1992 RESULTS: Expression levels of the renin mRNA in various parts of the central nervous system of 4-week-old spontaneously hypertensive rats were approximately twofold higher than those of age-matched Wistar-Kyoto rats and expression levels in the brain were positively modulated by the administration of either captopril or clonidine. Captopril 309-318 renin Rattus norvegicus 34-39 1325502-6 1992 RESULTS: Expression levels of the renin mRNA in various parts of the central nervous system of 4-week-old spontaneously hypertensive rats were approximately twofold higher than those of age-matched Wistar-Kyoto rats and expression levels in the brain were positively modulated by the administration of either captopril or clonidine. Clonidine 322-331 renin Rattus norvegicus 34-39 1409372-1 1992 Nasal absorption of O-(N-morpholino-carbonyl-3-L-phenylaspartyl-L-leucinamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (I), a renin inhibitor, was evaluated in two rat nasal models, one involving surgery and the other requiring no surgical intervention. o-(n-morpholino-carbonyl-3-l-phenylaspartyl-l-leucinamide 20-77 renin Rattus norvegicus 150-155 1438875-2 1992 Prostaglandin E2 (PGE2) and prostacyclin (PGI2) are promoters of natriuresis and renin release. Epoprostenol 28-40 renin Rattus norvegicus 81-86 1438875-2 1992 Prostaglandin E2 (PGE2) and prostacyclin (PGI2) are promoters of natriuresis and renin release. Epoprostenol 42-46 renin Rattus norvegicus 81-86 1438875-3 1992 Excessive prostaglandin production, therefore, might contribute to the altered sodium balance and renin release observed in primary adrenal insufficiency. Prostaglandins 10-23 renin Rattus norvegicus 98-103 1409479-14 1992 As regards renal functional reserve, response to the antidiuretic hormone in case of water restriction, or stimulation of the renin-angiotensin system in response to decrease of sodium intake, it is clear that the renal cells responsible for glomerular filtration, tubular transport or synthesis and release of peptidic hormones exhibit functional alterations that are age-related. Sodium 178-184 renin Rattus norvegicus 126-131 1325316-2 1992 The renin-angiotensin and kinin-kallikrein systems of Dahl salt-sensitive and salt-resistant rats fed diets with different salt contents were analysed using biochemical and immunocytochemical techniques. dahl salt 54-63 renin Rattus norvegicus 4-9 1321627-0 1992 Acute effects of cadmium on the renin angiotensin system in rats. Cadmium 17-24 renin Rattus norvegicus 32-37 1325316-6 1992 The plasma renin activity and the plasma angiotensin II concentration were elevated in both salt-resistant and salt-sensitive rats fed the salt-deficient diet but were much more elevated in salt-resistant than in salt-sensitive rats. Salts 111-115 renin Rattus norvegicus 11-16 1325316-9 1992 Salt-sensitive rats had fewer renin positive juxtaglomerular apparatuses than salt-resistant rats on the normal diet, and the increase on the sodium-deficient diet was also smaller in salt-sensitive rats. Salts 0-4 renin Rattus norvegicus 30-35 1325316-6 1992 The plasma renin activity and the plasma angiotensin II concentration were elevated in both salt-resistant and salt-sensitive rats fed the salt-deficient diet but were much more elevated in salt-resistant than in salt-sensitive rats. Salts 111-115 renin Rattus norvegicus 11-16 1325316-5 1992 The plasma renin activity and plasma angiotensin II concentration remained at the same levels in salt-sensitive rats on the high-salt diet as on the normal salt diet, whereas the plasma renin activity and plasma angiotensin II concentration of salt-resistant rats fed the high-salt diet were lower. Salts 97-101 renin Rattus norvegicus 11-16 1325316-6 1992 The plasma renin activity and the plasma angiotensin II concentration were elevated in both salt-resistant and salt-sensitive rats fed the salt-deficient diet but were much more elevated in salt-resistant than in salt-sensitive rats. Salts 92-96 renin Rattus norvegicus 11-16 1409781-0 1992 Cocaine-induced suppression of renin secretion is partially mediated by serotonergic mechanisms. Cocaine 0-7 renin Rattus norvegicus 31-36 1325316-6 1992 The plasma renin activity and the plasma angiotensin II concentration were elevated in both salt-resistant and salt-sensitive rats fed the salt-deficient diet but were much more elevated in salt-resistant than in salt-sensitive rats. Salts 111-115 renin Rattus norvegicus 11-16 1409781-3 1992 5-HT lesions attenuated the cocaine-induced reduction of plasma renin concentration (PRC), suggesting a partial 5-HT role. Cocaine 28-35 renin Rattus norvegicus 64-69 1325316-6 1992 The plasma renin activity and the plasma angiotensin II concentration were elevated in both salt-resistant and salt-sensitive rats fed the salt-deficient diet but were much more elevated in salt-resistant than in salt-sensitive rats. Salts 111-115 renin Rattus norvegicus 11-16 1409781-6 1992 The data suggest that cocaine"s effect is partially mediated by a serotonergic mechanism, but do not support a role for 5-HT1A receptors, 5-HT2/5-HT1C receptors, or alpha 2-adrenoceptors in mediating the suppressive effect of cocaine on renin secretion. Cocaine 22-29 renin Rattus norvegicus 237-242 1438002-1 1992 The oral delivery of O-(N-morpholino-carbonyl-3-L-phenylaspartyl-L- leucinamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylhetane (I), a new renin inhibitor, was studied in the in vivo rat model using emulsion formulations. o-(n-morpholino-carbonyl-3-l-phenylaspartyl-l- leucinamide 21-79 renin Rattus norvegicus 155-160 1635591-2 1992 SK&F 108566 produced dose-dependent decreases in blood pressure in renin-dependent hypertensive rats. amicloral 0-6 renin Rattus norvegicus 71-76 1592470-3 1992 Renin mRNA was detected in kidney but was not detected in aortic smooth muscle from the untreated or enalapril-treated groups. Enalapril 101-110 renin Rattus norvegicus 0-5 1630068-9 1992 The response to sodium depletion suggests a volume-dependent component, which may result from elevated aldosterone levels, possibly due to enhanced adrenal renin expression. Sodium 16-22 renin Rattus norvegicus 156-161 1630068-9 1992 The response to sodium depletion suggests a volume-dependent component, which may result from elevated aldosterone levels, possibly due to enhanced adrenal renin expression. Aldosterone 103-114 renin Rattus norvegicus 156-161 1602371-4 1992 In addition, SC-51316 inhibited AII-induced aldosterone release from rat adrenal zona glomerulosa cells and blocked inhibition of renin release by AII from rat kidney slices with pA2 values of 8.62 and 8.9, respectively. SC 51316 13-21 renin Rattus norvegicus 130-135 1602371-6 1992 These data demonstrate that SC-51316 is a potent AII receptor antagonist which may prove to be useful as a pharmacologic tool for studying the role of the renin-angiotensin system in cardiovascular diseases. SC 51316 28-36 renin Rattus norvegicus 155-160 1396991-5 1992 This hypertensive response to rh-renin was antagonized by renin inhibitors, YM-21095 and KRI-1314, which inhibited the reaction between rh-renin and tetradecapeptide competitively, with Ki values of 5.1 x 10(-10) and 4.3 x 10(-9) M, respectively. YM 21095 76-84 renin Rattus norvegicus 33-38 1439079-0 1992 [Effect of brain serotonin on the arterial pressure and plasma renin in normal and hypertensive rats]. Serotonin 17-26 renin Rattus norvegicus 63-68 1354556-10 1992 However, the ACTH response to CER was significantly (P less than 0.01) inhibited by all doses of ipsapirone and the highest dose of ipsapirone attenuated the renin response. ipsapirone 132-142 renin Rattus norvegicus 158-163 1354556-16 1992 Of the hormones studied, the stimulation of renin secretion after exposure to the three stressors was most sensitive to ipsapirone, while corticosterone and prolactin were the least sensitive to ipsapirone. ipsapirone 120-130 renin Rattus norvegicus 44-49 1504817-0 1992 Repeated injections of cocaine inhibit the serotonergic regulation of prolactin and renin secretion in rats. Cocaine 23-30 renin Rattus norvegicus 84-89 1504817-7 1992 In rats receiving cocaine for 7 days, the attenuation of PCA-induced secretion of prolactin and renin was less consistently observed. Cocaine 18-25 renin Rattus norvegicus 96-101 1396991-5 1992 This hypertensive response to rh-renin was antagonized by renin inhibitors, YM-21095 and KRI-1314, which inhibited the reaction between rh-renin and tetradecapeptide competitively, with Ki values of 5.1 x 10(-10) and 4.3 x 10(-9) M, respectively. YM 21095 76-84 renin Rattus norvegicus 58-63 1396991-5 1992 This hypertensive response to rh-renin was antagonized by renin inhibitors, YM-21095 and KRI-1314, which inhibited the reaction between rh-renin and tetradecapeptide competitively, with Ki values of 5.1 x 10(-10) and 4.3 x 10(-9) M, respectively. YM 21095 76-84 renin Rattus norvegicus 58-63 1396991-5 1992 This hypertensive response to rh-renin was antagonized by renin inhibitors, YM-21095 and KRI-1314, which inhibited the reaction between rh-renin and tetradecapeptide competitively, with Ki values of 5.1 x 10(-10) and 4.3 x 10(-9) M, respectively. KRI 1314 89-97 renin Rattus norvegicus 33-38 1396991-5 1992 This hypertensive response to rh-renin was antagonized by renin inhibitors, YM-21095 and KRI-1314, which inhibited the reaction between rh-renin and tetradecapeptide competitively, with Ki values of 5.1 x 10(-10) and 4.3 x 10(-9) M, respectively. KRI 1314 89-97 renin Rattus norvegicus 58-63 1396991-5 1992 This hypertensive response to rh-renin was antagonized by renin inhibitors, YM-21095 and KRI-1314, which inhibited the reaction between rh-renin and tetradecapeptide competitively, with Ki values of 5.1 x 10(-10) and 4.3 x 10(-9) M, respectively. KRI 1314 89-97 renin Rattus norvegicus 58-63 1396991-6 1992 In rh-renin-infused pithed SHR, the hypotensive effect of YM-21095 was 37 times as potent as that of KRI-1314. YM 21095 58-66 renin Rattus norvegicus 6-11 1396991-6 1992 In rh-renin-infused pithed SHR, the hypotensive effect of YM-21095 was 37 times as potent as that of KRI-1314. KRI 1314 101-109 renin Rattus norvegicus 6-11 1313394-5 1992 Plasma renin activity was significantly lower in the N omega-monomethyl-L-arginine- and N omega-nitro-L-arginine methyl ester-treated groups than in the vehicle-treated group. omega-monomethyl-l-arginine 55-82 renin Rattus norvegicus 7-12 1533286-8 1992 Plasma renin activity in ng angiotensin l/ml/hr averaged 1.80 +/- 0.15 in the normal salt group of rats and was significantly higher in the low salt group of rats (5.66 +/- 1.07, P less than 0.05). Salts 85-89 renin Rattus norvegicus 7-12 1325309-6 1992 This study was undertaken to assess whether the NPY induced renin suppression in awake normotensive rats infused with the beta-adrenoceptor stimulant isoproterenol is mediated by activation of pre- or post-synaptic receptors. Isoproterenol 150-163 renin Rattus norvegicus 60-65 1325309-8 1992 Non-pressor doses of (1-36)-NPY and (Pro34)-NPY markedly attenuated the renin secretion triggered by isoproterenol whereas (13-36)-NPY had no effect. Isoproterenol 101-114 renin Rattus norvegicus 72-77 1568764-8 1992 Orchidectomy retarded the development of hypertension and lowered plasma renin and renal and hepatic angiotensinogen mRNA levels, and testosterone replacement restored the male pattern of hypertension and plasma renin and increased renal and hepatic angiotensinogen mRNA. Testosterone 134-146 renin Rattus norvegicus 212-217 1317902-4 1992 The converting enzyme inhibitor, cilazapril, was then infused at increasing dose levels to progressively block the renin-angiotensin system. Cilazapril 33-43 renin Rattus norvegicus 115-120 1387008-8 1992 In losartan-treated rats, plasma renin and angiotensin II concentration were increased between 4- and 7-fold at the end of both treatment periods. Losartan 3-11 renin Rattus norvegicus 33-38 1566837-5 1992 Salt loading suppressed plasma renin activity by 42% (P less than 0.05) in R rats and plasma aldosterone by 66 and 33% (P less than 0.01) in R and S rats, respectively. Salts 0-4 renin Rattus norvegicus 31-36 1498715-12 1992 This effect may relate to a marked reduction in the pressor effectiveness of the renin-angiotensin system by low sodium intake per se or by associated metabolic or other changes. Sodium 113-119 renin Rattus norvegicus 81-86 1313394-5 1992 Plasma renin activity was significantly lower in the N omega-monomethyl-L-arginine- and N omega-nitro-L-arginine methyl ester-treated groups than in the vehicle-treated group. NG-Nitroarginine Methyl Ester 88-125 renin Rattus norvegicus 7-12 1560388-0 1992 Renin-angiotensin system inhibition reduces glycine-induced glomerular hyperfiltration in conscious rats. Glycine 44-51 renin Rattus norvegicus 0-5 1560388-2 1992 We therefore investigated the effect of inhibition of the renin-angiotensin system by SK&F 108566, a novel, nonpeptide angiotensin II (AII) receptor antagonist, or by enalapril, an angiotensin converting enzyme inhibitor, on glycine-induced hyperfiltration. amicloral 86-92 renin Rattus norvegicus 58-63 1513111-6 1992 Whereas plasma renin activity rose in both the perindopril and triple therapy groups, it is likely that the effects on angiotensin II levels were opposite since perindopril but not triple therapy was associated with a significant reduction in plasma angiotensin converting enzyme activity. Perindopril 47-58 renin Rattus norvegicus 15-20 1513102-2 1992 In this study, the local intrarenal renin-angiotensin system was examined in streptozotocin-treated rats maintained moderately hyperglycemic by daily low-dose insulin injection. Streptozocin 77-91 renin Rattus norvegicus 36-41 1312512-8 1992 Both ACTH and db-cAMP significantly stimulated active renin in the cells (ACTH, 1.73 +/- 0.14 to 9.44 +/- 0.98; db-cAMP, 1.45 +/- 0.16 to 3.96 +/- 0.71 ng Ang I/10(6) cells) and inactive renin in the medium (ACTH, 4.98 +/- 0.38 to 43.7 +/- 5.63; db-cAMP, 3.80 +/- 0.32 to 33.55 +/- 5.62 ng Ang I/10(6) cells). db-cAMP 14-21 renin Rattus norvegicus 54-59 1558208-6 1992 Plasma renin activity was elevated to the same level by isoproterenol in both strains of rats. Isoproterenol 56-69 renin Rattus norvegicus 7-12 1558208-7 1992 These results suggest that the ability of isoproterenol to release renin, the subsequent generation of ANG I, and the conversion to ANG II are similar in the two strains. Isoproterenol 42-55 renin Rattus norvegicus 67-72 1558158-0 1992 Involvement of chloride in renin secretion from isolated rat glomeruli. Chlorides 15-23 renin Rattus norvegicus 27-32 1558158-1 1992 The sensitivity of renin release to changes in anion and calcium concentrations was assessed in superfused rat glomeruli with attached juxtaglomerular cells. Calcium 57-64 renin Rattus norvegicus 19-24 1558158-3 1992 Substitution of Cl- with nitrate (101 mM) stimulated renin secretion. Nitrates 25-32 renin Rattus norvegicus 53-58 1558158-7 1992 In May reintroduction of calcium and chloride stimulated renin release, suggesting that releasable renin had been stockpiled during the exposure to calcium-free solution. Calcium 25-32 renin Rattus norvegicus 57-62 1558158-7 1992 In May reintroduction of calcium and chloride stimulated renin release, suggesting that releasable renin had been stockpiled during the exposure to calcium-free solution. Calcium 25-32 renin Rattus norvegicus 99-104 1558158-7 1992 In May reintroduction of calcium and chloride stimulated renin release, suggesting that releasable renin had been stockpiled during the exposure to calcium-free solution. Chlorides 37-45 renin Rattus norvegicus 57-62 1558158-7 1992 In May reintroduction of calcium and chloride stimulated renin release, suggesting that releasable renin had been stockpiled during the exposure to calcium-free solution. Chlorides 37-45 renin Rattus norvegicus 99-104 1558158-7 1992 In May reintroduction of calcium and chloride stimulated renin release, suggesting that releasable renin had been stockpiled during the exposure to calcium-free solution. Calcium 148-155 renin Rattus norvegicus 99-104 1558158-8 1992 In September reintroduction of calcium and chloride inhibited renin release. Calcium 31-38 renin Rattus norvegicus 62-67 1558158-8 1992 In September reintroduction of calcium and chloride inhibited renin release. Chlorides 43-51 renin Rattus norvegicus 62-67 1312512-8 1992 Both ACTH and db-cAMP significantly stimulated active renin in the cells (ACTH, 1.73 +/- 0.14 to 9.44 +/- 0.98; db-cAMP, 1.45 +/- 0.16 to 3.96 +/- 0.71 ng Ang I/10(6) cells) and inactive renin in the medium (ACTH, 4.98 +/- 0.38 to 43.7 +/- 5.63; db-cAMP, 3.80 +/- 0.32 to 33.55 +/- 5.62 ng Ang I/10(6) cells). db-cAMP 14-21 renin Rattus norvegicus 187-192 1312512-8 1992 Both ACTH and db-cAMP significantly stimulated active renin in the cells (ACTH, 1.73 +/- 0.14 to 9.44 +/- 0.98; db-cAMP, 1.45 +/- 0.16 to 3.96 +/- 0.71 ng Ang I/10(6) cells) and inactive renin in the medium (ACTH, 4.98 +/- 0.38 to 43.7 +/- 5.63; db-cAMP, 3.80 +/- 0.32 to 33.55 +/- 5.62 ng Ang I/10(6) cells). db-cAMP 112-119 renin Rattus norvegicus 54-59 1312512-8 1992 Both ACTH and db-cAMP significantly stimulated active renin in the cells (ACTH, 1.73 +/- 0.14 to 9.44 +/- 0.98; db-cAMP, 1.45 +/- 0.16 to 3.96 +/- 0.71 ng Ang I/10(6) cells) and inactive renin in the medium (ACTH, 4.98 +/- 0.38 to 43.7 +/- 5.63; db-cAMP, 3.80 +/- 0.32 to 33.55 +/- 5.62 ng Ang I/10(6) cells). db-cAMP 112-119 renin Rattus norvegicus 54-59 1312512-9 1992 The addition of Ang II (10(-7) M) blunted the stimulation of renin production by both ACTH and db-cAMP by 60%. db-cAMP 95-102 renin Rattus norvegicus 61-66 1312512-10 1992 High potassium-stimulated renin production was not inhibited by Ang II. Potassium 5-14 renin Rattus norvegicus 26-31 1310248-10 1992 These results confirm previous work and extend the data base supporting the idea that the renin-angiotensin system plays a role in modulating intake of ethanol. Ethanol 152-159 renin Rattus norvegicus 90-95 1735597-1 1992 Although endothelium-derived prostaglandin I2 stimulates renin release, exogenous endothelium-derived relaxing factor (EDRF) can inhibit it. Epoprostenol 29-45 renin Rattus norvegicus 57-62 1735597-4 1992 NG-Monomethyl-L-arginine (LNMMA) (10(-4) M), which blocks EDRF formation, significantly enhanced basal renin release from kidney slices by more than 50% in control medium (40.0 +/- 14.3 ng Ang I/hr/mg/30 min; p less than 0.01) or in medium treated with 1.6 x 10(-5) M meclofenamate (50.8 +/- 8.4 ng Ang I; p less than 0.025). omega-N-Methylarginine 0-24 renin Rattus norvegicus 103-108 1735597-4 1992 NG-Monomethyl-L-arginine (LNMMA) (10(-4) M), which blocks EDRF formation, significantly enhanced basal renin release from kidney slices by more than 50% in control medium (40.0 +/- 14.3 ng Ang I/hr/mg/30 min; p less than 0.01) or in medium treated with 1.6 x 10(-5) M meclofenamate (50.8 +/- 8.4 ng Ang I; p less than 0.025). omega-N-Methylarginine 26-31 renin Rattus norvegicus 103-108 1735597-5 1992 Isoproterenol (10(-5) M)-stimulated renin release (40.0 +/- 14.3 ng Ang I; p less than 0.02) was not modified by LNMMA; addition of L-arginine (10(-5) M), the precursor of EDRF, did not change basal but blocked isoproterenol stimulation of renin. Isoproterenol 0-13 renin Rattus norvegicus 36-41 1735597-5 1992 Isoproterenol (10(-5) M)-stimulated renin release (40.0 +/- 14.3 ng Ang I; p less than 0.02) was not modified by LNMMA; addition of L-arginine (10(-5) M), the precursor of EDRF, did not change basal but blocked isoproterenol stimulation of renin. Isoproterenol 0-13 renin Rattus norvegicus 240-245 1735597-6 1992 Nitroprusside (10(-5) M) completely reversed melittin-stimulated renin release. Nitroprusside 0-13 renin Rattus norvegicus 65-70 1543706-2 1992 EMD 55068), a synthetic renin-antagonist, competitively inhibits the uptake of taurocholate and of another linear peptide (EMD 51921) but not of oleic acid, serine or thiamin hydrochloride into isolated rat liver cells. Taurocholic Acid 79-91 renin Rattus norvegicus 24-29 1315824-5 1992 In rats dosed with DOCA-salt (which suppresses renin and angiotensin II production): (1) there was no synergism between the hypotensive actions of enalaprilat and doxazosin; (2) doxazosin was more potent than in untreated rats; and (3) enalaprilat lowered blood pressure, suggesting a hypotensive mechanism separate from ACE inhibition. doca-salt 19-28 renin Rattus norvegicus 47-71 1535317-0 1992 Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Serotonin 36-45 renin Rattus norvegicus 99-104 1346623-0 1992 A biphasic effect of noradrenaline on renin release from rat juxtaglomerular cells in vitro is mediated by alpha 1- and beta-adrenoceptors. Norepinephrine 21-34 renin Rattus norvegicus 38-43 1733240-0 1992 Downregulation of the renin-angiotensin system in streptozotocin-diabetic rats. Streptozocin 50-64 renin Rattus norvegicus 22-27 1733240-6 1992 Plasma renin activity (PRA) was significantly decreased in STZ-diabetic rats; however, plasma angiotensinogen concentration was not significantly affected by diabetes. Streptozocin 59-62 renin Rattus norvegicus 7-12 1733240-8 1992 Kidney renin mRNA as well as liver, epididymal, and interscapular fat angiotensinogen mRNA were significantly decreased in STZ-diabetic rats. Streptozocin 123-126 renin Rattus norvegicus 7-12 1733240-10 1992 Results from this study suggest a downregulation of the renin-angiotensin system in 4-wk STZ-diabetic rats at the level of mRNA expression that is restored by replacement therapy with insulin; therefore, insulin may directly or indirectly regulate the renin-angiotensin system. Streptozocin 89-92 renin Rattus norvegicus 56-61 1343280-4 1992 Although delapril markedly increased plasma renin activity (PRA), manidipine did not alter PRA. delapril 9-17 renin Rattus norvegicus 44-49 1577017-1 1992 Vasoconstriction, caused by activation of the renin-angiotensin system contributes to myocardial damage during ischaemia; the converting enzyme inhibitor, captopril, suppresses angiotensin formation. Captopril 155-164 renin Rattus norvegicus 46-51 1468598-8 1992 In these experiments, a positive correlation between adrenal renin and aldosterone concentration is found. Aldosterone 71-82 renin Rattus norvegicus 61-66 1733312-0 1992 Adaptation to sodium restriction in renin-immunized spontaneously hypertensive and normotensive rats. Sodium 14-20 renin Rattus norvegicus 36-41 1733312-1 1992 The influence of active immunization against renin on the systemic and renal adaptation to abrupt suppression of dietary sodium was assessed in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. Sodium 121-127 renin Rattus norvegicus 45-50 1343292-6 1992 Although delapril increased plasma renin activity (PRA) about 5-fold compared with the control group, manidipine did not change PRA. delapril 9-17 renin Rattus norvegicus 35-40 1343292-7 1992 The kidney renin mRNA content was increased about 6-fold by treatment with delapril. delapril 75-83 renin Rattus norvegicus 11-16 1343292-8 1992 Manidipine and delapril significantly decreased the renin mRNA content in the heart (p < 0.01 and p < 0.05, respectively). manidipine 0-10 renin Rattus norvegicus 52-57 1343292-8 1992 Manidipine and delapril significantly decreased the renin mRNA content in the heart (p < 0.01 and p < 0.05, respectively). delapril 15-23 renin Rattus norvegicus 52-57 1540848-2 1992 The response of rats with AV3V damage to sodium depletion was retarded and the excess sodium intake that is induced by pICV renin was absent, but their daily need-free sodium intake and the sodium intake that is induced by DOCA were essentially normal. Sodium 86-92 renin Rattus norvegicus 124-129 1540848-2 1992 The response of rats with AV3V damage to sodium depletion was retarded and the excess sodium intake that is induced by pICV renin was absent, but their daily need-free sodium intake and the sodium intake that is induced by DOCA were essentially normal. Sodium 86-92 renin Rattus norvegicus 124-129 1540848-2 1992 The response of rats with AV3V damage to sodium depletion was retarded and the excess sodium intake that is induced by pICV renin was absent, but their daily need-free sodium intake and the sodium intake that is induced by DOCA were essentially normal. Sodium 86-92 renin Rattus norvegicus 124-129 1639204-7 1992 We observed in an isolated perfused rat kidney that the compound L-NAME (NG-monomethyl-L-arginine methyl ester), a competitive inhibitor of NO synthase blocking the production of NO, induces renal vasoconstriction and inhibits renin release. NG-Nitroarginine Methyl Ester 65-71 renin Rattus norvegicus 227-232 1639204-7 1992 We observed in an isolated perfused rat kidney that the compound L-NAME (NG-monomethyl-L-arginine methyl ester), a competitive inhibitor of NO synthase blocking the production of NO, induces renal vasoconstriction and inhibits renin release. ng-monomethyl-l-arginine methyl ester 73-110 renin Rattus norvegicus 227-232 1346623-1 1992 The direct effect of noradrenaline on renin release from juxtaglomerular (JG) cells in vitro were investigated in a dynamic superfusion system of dispersed rat renal cortical cells. Norepinephrine 21-34 renin Rattus norvegicus 38-43 1346623-2 1992 At low concentrations (1-100 nmol/l), noradrenaline stimulated renin release in a dose-dependent manner, while at higher concentrations (0.1-1 mmol/l) it inhibited renin release. Norepinephrine 38-51 renin Rattus norvegicus 63-68 1346623-2 1992 At low concentrations (1-100 nmol/l), noradrenaline stimulated renin release in a dose-dependent manner, while at higher concentrations (0.1-1 mmol/l) it inhibited renin release. Norepinephrine 38-51 renin Rattus norvegicus 164-169 1346623-6 1992 These results indicate that low concentrations of noradrenaline directly stimulate renin release from JG cells by the activation of beta-adrenoceptors, while high concentrations of noradrenaline inhibit renin release by the activation of alpha 1-adrenoceptors. Norepinephrine 50-63 renin Rattus norvegicus 83-88 1346623-6 1992 These results indicate that low concentrations of noradrenaline directly stimulate renin release from JG cells by the activation of beta-adrenoceptors, while high concentrations of noradrenaline inhibit renin release by the activation of alpha 1-adrenoceptors. Norepinephrine 181-194 renin Rattus norvegicus 203-208 1823033-3 1991 By differential centrifugation of tissue homogenate in 0.25 M sucrose/30 mM Tris-HCl/l mM EDTA, pH 7.4, specific immunoreactive renin was found to be localized principally (60%) in the mitochondrial fraction (P2), whereas about 40% of both angiotensins I and II was contained in the soluble fraction; only 18-20% of both peptides was contained in the P2 fraction. Sucrose 62-69 renin Rattus norvegicus 128-133 1325586-5 1992 Cocaine increased plasma ACTH and corticosterone, while it decreased prolactin and renin concentrations. Cocaine 0-7 renin Rattus norvegicus 83-88 1552826-0 1992 Decreased renin release and constant kallikrein secretion after injection of L-NAME in isolated perfused rat kidney. NG-Nitroarginine Methyl Ester 77-83 renin Rattus norvegicus 10-15 1552826-5 1992 These results confirm the intervention of the L-arginine/NO pathway in the vasodilation of this isolated perfused kidney model and demonstrate the inhibitory effect of L-NAME on renin release. NG-Nitroarginine Methyl Ester 168-174 renin Rattus norvegicus 178-183 1552826-6 1992 They suggest that nitric oxide synthesis plays a role in stimulating renin release and is not involved in the regulation of urinary kallikrein secretion. Nitric Oxide 18-30 renin Rattus norvegicus 69-74 1636021-0 1992 Effect of captopril on urinary excretion of renin and angiotensinogen in aminonucleoside nephrosis. Captopril 10-19 renin Rattus norvegicus 44-49 1636021-1 1992 Puromycin aminonucleoside (PAN)-nephrotic rats show high plasma renin, low plasma angiotensinogen (Angt), and increased urinary excretion of renin and Angt. Puromycin Aminonucleoside 0-25 renin Rattus norvegicus 64-69 1636021-1 1992 Puromycin aminonucleoside (PAN)-nephrotic rats show high plasma renin, low plasma angiotensinogen (Angt), and increased urinary excretion of renin and Angt. Puromycin Aminonucleoside 0-25 renin Rattus norvegicus 141-146 1636021-3 1992 Captopril had no effect on total protein urinary excretion; however, captopril did enhance the urinary excretion of renin and did decrease the urinary excretion of Angt. Captopril 69-78 renin Rattus norvegicus 116-121 1636021-4 1992 This seems to be due to the fact that captopril magnifies the increase in renin and the decrease in Angt in the plasma of PAN-nephrotic rats. Captopril 38-47 renin Rattus norvegicus 74-79 1804631-5 1991 Endogenous angiotensin formation was blocked by the angiotensin converting enzyme inhibitors captopril and ramiprilat and the activity of the endogenous renin-angiotensin system was modulated by variations in nutritional sodium load prior to the experiments. Sodium 221-227 renin Rattus norvegicus 153-158 1522747-0 1992 Dantrolene stimulates renin secretion by rat renal cortical slices but fails to block calcium-dependent inhibition. Dantrolene 0-10 renin Rattus norvegicus 22-27 1522747-1 1992 Calcium (Ca) is an inhibitory second messenger in renin secretion, and it has been proposed that some first messengers, such as angiotensin II (A-II), antidiuretic hormone (ADH), and N6-cyclohexyladenosine (CHA), increase Ca and thereby inhibit renin secretion by mobilizing Ca from intracellular sequestration sites. Calcium 0-7 renin Rattus norvegicus 50-55 1522747-1 1992 Calcium (Ca) is an inhibitory second messenger in renin secretion, and it has been proposed that some first messengers, such as angiotensin II (A-II), antidiuretic hormone (ADH), and N6-cyclohexyladenosine (CHA), increase Ca and thereby inhibit renin secretion by mobilizing Ca from intracellular sequestration sites. Calcium 0-7 renin Rattus norvegicus 245-250 1522747-3 1992 Dantrolene stimulated renin secretion by rat renal cortical slices in a concentration dependent manner; at 0.0, 0.1, and 0.5 mM dantrolene, secretory rates were 8.1 +/- 0.6, 9.4 +/- 0.6 (p less than 0.05), and 14.9 +/- 1.2 (p less than 0.0001) GU/g x hr, respectively. Dantrolene 0-10 renin Rattus norvegicus 22-27 1522747-4 1992 These results could be interpreted to mean that Ca mobilization is occurring at a finite rate during the basal state, and that by antagonizing this process, dantrolene lowers intracellular Ca and thereby stimulates renin secretion. Dantrolene 157-167 renin Rattus norvegicus 215-220 1522747-5 1992 However, 0.1 mM dantrolene failed to antagonize the inhibitory effects on renin secretion of A-II, ADH, and CHA, and only CHA-induced inhibition of renin secretion was antagonized by 0.5 mM dantrolene. N(6)-cyclohexyladenosine 122-125 renin Rattus norvegicus 148-153 1522747-6 1992 We conclude that if A-II, ADH, and CHA inhibit renin secretion by mobilizing Ca from an intracellular storage site, then the site is insensitive to dantrolene. N(6)-cyclohexyladenosine 35-38 renin Rattus norvegicus 47-52 1462001-7 1992 DOCA plus saline drinking significantly suppressed the plasma renin activity (PRA) but saline drinking alone did not. Desoxycorticosterone Acetate 0-4 renin Rattus norvegicus 62-67 1462001-7 1992 DOCA plus saline drinking significantly suppressed the plasma renin activity (PRA) but saline drinking alone did not. Sodium Chloride 10-16 renin Rattus norvegicus 62-67 1462001-9 1992 The data suggest that the beneficial effect of DOCA plus saline drinking is associated with renin-angiotensin suppression rather than with the renal GM content or well-maintained hydration. Desoxycorticosterone Acetate 47-51 renin Rattus norvegicus 92-97 1462001-9 1992 The data suggest that the beneficial effect of DOCA plus saline drinking is associated with renin-angiotensin suppression rather than with the renal GM content or well-maintained hydration. Sodium Chloride 57-63 renin Rattus norvegicus 92-97 1725739-6 1991 Alterations in plasma renin activity (PRA) were a consequence of PRC and PAC changes in thyroidectomized animals, as an increase in fractional sodium excretion (FENa) time course dependent, was found in these rats. Sodium 143-149 renin Rattus norvegicus 22-27 1725739-6 1991 Alterations in plasma renin activity (PRA) were a consequence of PRC and PAC changes in thyroidectomized animals, as an increase in fractional sodium excretion (FENa) time course dependent, was found in these rats. fena 161-165 renin Rattus norvegicus 22-27 1823883-11 1991 The mechanism of the control of renin secretion from the adrenal gland was different from the kidney in that the release was stimulated by potassium chloride or angiotensin II but not by ACTH, suggesting stimulation by intracellular calcium. Potassium Chloride 139-157 renin Rattus norvegicus 32-37 1823033-3 1991 By differential centrifugation of tissue homogenate in 0.25 M sucrose/30 mM Tris-HCl/l mM EDTA, pH 7.4, specific immunoreactive renin was found to be localized principally (60%) in the mitochondrial fraction (P2), whereas about 40% of both angiotensins I and II was contained in the soluble fraction; only 18-20% of both peptides was contained in the P2 fraction. Tromethamine 76-80 renin Rattus norvegicus 128-133 1823883-11 1991 The mechanism of the control of renin secretion from the adrenal gland was different from the kidney in that the release was stimulated by potassium chloride or angiotensin II but not by ACTH, suggesting stimulation by intracellular calcium. Calcium 233-240 renin Rattus norvegicus 32-37 1823883-13 1991 It is most likely that the adrenal renin plays a role in the production of aldosterone in the adrenal cortex or in the secretion of catecholamines from the adrenal medulla through intra- and/or extracellular formation of angiotensin II. Aldosterone 75-86 renin Rattus norvegicus 35-40 1660448-4 1991 In plasma, the highest dose of perindopril reduced angiotensin converting enzyme activity to 11% of control, increased renin 200-fold, reduced angiotensinogen to 11% of control, increased angiotensin-(1-7), angiotensin I, angiotensin-(2-7), and angiotensin-(2-10) levels 25-, 9-, 10-, and 13-fold, respectively; angiotensin II levels were not significantly different from control. Perindopril 31-42 renin Rattus norvegicus 119-124 1823033-3 1991 By differential centrifugation of tissue homogenate in 0.25 M sucrose/30 mM Tris-HCl/l mM EDTA, pH 7.4, specific immunoreactive renin was found to be localized principally (60%) in the mitochondrial fraction (P2), whereas about 40% of both angiotensins I and II was contained in the soluble fraction; only 18-20% of both peptides was contained in the P2 fraction. Hydrochloric Acid 81-84 renin Rattus norvegicus 128-133 1823883-13 1991 It is most likely that the adrenal renin plays a role in the production of aldosterone in the adrenal cortex or in the secretion of catecholamines from the adrenal medulla through intra- and/or extracellular formation of angiotensin II. Catecholamines 132-146 renin Rattus norvegicus 35-40 1823033-3 1991 By differential centrifugation of tissue homogenate in 0.25 M sucrose/30 mM Tris-HCl/l mM EDTA, pH 7.4, specific immunoreactive renin was found to be localized principally (60%) in the mitochondrial fraction (P2), whereas about 40% of both angiotensins I and II was contained in the soluble fraction; only 18-20% of both peptides was contained in the P2 fraction. Edetic Acid 90-94 renin Rattus norvegicus 128-133 1748165-4 1991 Plasma renin activity were markedly increased throughout the experimental period in both rats treated with captopril, and were modestly increased in 2 KGH rats. Captopril 107-116 renin Rattus norvegicus 7-12 1812004-5 1991 Higher doses of torasemide (10 mg/kg) and furosemide (100 mg/kg) increased both plasma renin activity and aldosterone concentration in normotensive rats in a similar manner. Torsemide 16-26 renin Rattus norvegicus 87-92 1812004-5 1991 Higher doses of torasemide (10 mg/kg) and furosemide (100 mg/kg) increased both plasma renin activity and aldosterone concentration in normotensive rats in a similar manner. Furosemide 42-52 renin Rattus norvegicus 87-92 1951766-4 1991 Male Sprague-Dawley strain rats were dehydrated by exposure to a 40 degree C environment for 2-4 h or by water deprivation for 44 h. Water deprivation but not heat exposure significantly increased plasma renin activity. Water 133-138 renin Rattus norvegicus 204-209 1837733-5 1991 Plasma renin activity was depressed in rats fed on supplemental Na and even more in rats fed on supplemental K salts rather than the basal diet. k salts 109-116 renin Rattus norvegicus 7-12 1928340-1 1991 In rats, plasma renin activity (PRA) increases sharply, reaching a plateau within hours of sodium restriction. Sodium 91-97 renin Rattus norvegicus 16-21 1920135-5 1991 The 5-HT1C/5-HT2 antagonist ritanserin completely blocked the DOI-induced increase in plasma renin activity. Ritanserin 28-38 renin Rattus norvegicus 93-98 1920135-7 1991 Low doses of spiperone (0.01 and 0.1 mg/kg, s.c.) significantly reduced the renin response to DOI. Spiperone 13-22 renin Rattus norvegicus 76-81 1920135-8 1991 Because spiperone has a higher affinity for 5-HT2 than 5-HT1C receptors, these data suggest that DOI stimulates renin secretion through 5-HT2 receptors. Spiperone 8-17 renin Rattus norvegicus 112-117 1920135-10 1991 Xylamidine produced a shift to the right and suppression of the maximal effect of DOI on plasma renin activity, suggesting a role for peripheral 5-HT2 receptors in the effect of DOI. xylamidine 0-10 renin Rattus norvegicus 96-101 1764812-9 1991 Interestingly, the brain renin and angiotensinogen mRNA levels of the two groups were similar, but the renal renin mRNA level was significantly higher in the Spirapril-treated group (P less than 0.01). spirapril 158-167 renin Rattus norvegicus 109-114 1786509-9 1991 GTN elicited significant hypotension and increases in renal blood flow and vascular conductance, indicating that activation of the renin-angiotension system opposed the dilator effects of GTN in this vascular bed. Nitroglycerin 0-3 renin Rattus norvegicus 131-136 1887949-10 1991 Plasma renin activity and urinary aldosterone were elevated in low-NaCl and Na(+)-depleted rats relative to the Cl(-)-depleted group (P less than 0.05). Sodium Chloride 67-71 renin Rattus norvegicus 7-12 1887949-12 1991 Salt appetite may be controlled by central or peripheral systems specifically sensitive to Na+ or by hormonal changes characteristic of Na+ depletion, such as the activation of renin and aldosterone observed in the low-NaCl and low-Na+ groups. Salts 0-4 renin Rattus norvegicus 177-182 1887949-12 1991 Salt appetite may be controlled by central or peripheral systems specifically sensitive to Na+ or by hormonal changes characteristic of Na+ depletion, such as the activation of renin and aldosterone observed in the low-NaCl and low-Na+ groups. Sodium Chloride 219-223 renin Rattus norvegicus 177-182 1786509-9 1991 GTN elicited significant hypotension and increases in renal blood flow and vascular conductance, indicating that activation of the renin-angiotension system opposed the dilator effects of GTN in this vascular bed. Nitroglycerin 188-191 renin Rattus norvegicus 131-136 1786509-19 1991 In the presence of captopril or enalaprilat, molsidomine evoked renal and mesenteric vasodilatations in association with hypotension, indicating that activation of the renin-angiotensin system contributed to the lack of vasodilator responses to administration of molsidomine alone. Molsidomine 45-56 renin Rattus norvegicus 168-173 1933358-6 1991 An additional NaCl supplementation (0.02% in the drinking water) to K(+)-depleted rats produced a decrease in plasma renin activity but failed to affect subfornical organ or paraventricular angiotensin II receptor number. Sodium Chloride 14-18 renin Rattus norvegicus 117-122 1756439-3 1991 Kidney renin messenger RNA was quantified by densitometric Northern blot analysis using 32P-labeled rat renin genomic DNA as a hybridization probe. Phosphorus-32 88-91 renin Rattus norvegicus 7-12 1756439-3 1991 Kidney renin messenger RNA was quantified by densitometric Northern blot analysis using 32P-labeled rat renin genomic DNA as a hybridization probe. Phosphorus-32 88-91 renin Rattus norvegicus 104-109 1714830-11 1991 PTH also reversed the effects of BAY-K8644 to suppress renin release. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 33-42 renin Rattus norvegicus 55-60 1756435-5 1991 In renin granules, equilibrated in fractions of 1.6 and 1.7 mol/L sucrose in discontinuous density gradient, trypsin-activatable renin activity formed 36 and 16% of total activity, respectively. Sucrose 66-73 renin Rattus norvegicus 129-134 1714830-0 1991 Parathyroid hormone and calcium: interactions in the control of renin secretion in the isolated, nonfiltering rat kidney. Calcium 24-31 renin Rattus norvegicus 64-69 1714830-1 1991 The present study was designed to characterize the interaction of calcium and PTH in the control of renin release in isolated rat kidneys perfused in a closed circuit at constant flow. Calcium 66-73 renin Rattus norvegicus 100-105 1714830-4 1991 In the absence of PTH, renin release was inversely correlated with ionized calcium (Ca2+) concentration, with the highest release of renin noted with 1 mM EGTA and no added calcium. Calcium 75-82 renin Rattus norvegicus 23-28 1714830-4 1991 In the absence of PTH, renin release was inversely correlated with ionized calcium (Ca2+) concentration, with the highest release of renin noted with 1 mM EGTA and no added calcium. Egtazic Acid 155-159 renin Rattus norvegicus 23-28 1714830-4 1991 In the absence of PTH, renin release was inversely correlated with ionized calcium (Ca2+) concentration, with the highest release of renin noted with 1 mM EGTA and no added calcium. Egtazic Acid 155-159 renin Rattus norvegicus 133-138 1714830-5 1991 Also, verapamil treatment markedly elevated renin release, even in the presence of 2 mM Ca2+. Verapamil 6-15 renin Rattus norvegicus 44-49 1714830-6 1991 In contrast, renin secretion was strongly depressed by 20 nM BAY-K8644 in the perfusate. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 61-70 renin Rattus norvegicus 13-18 1889842-3 1991 The antihypertensive effects of DuP 753 and its effects on circulating parameters of the renin-angiotensin system were compared with those of a converting enzyme inhibitor (benazeprilat). Losartan 32-39 renin Rattus norvegicus 89-94 1889842-10 1991 In rats treated with benazeprilat, plasma renin concentration increased threefold, whereas angiotensin II was unchanged. benazeprilat 21-33 renin Rattus norvegicus 42-47 1816382-16 1991 The stimulatory effect of AVP on renin release could be mimicked by [deamino-Cys1, D-Arg8]-vasopressin (dDAVP), a vasopressin analogue with prevalent V2 receptor agonistic properties. Deuterium 83-85 renin Rattus norvegicus 33-38 1816382-20 1991 The vasoconstrictor effect of KCl was paralleled by an increase of the arterio-venous difference of perfusate renin activity to such an extent that the rate of renin release remained unaltered. Potassium Chloride 30-33 renin Rattus norvegicus 110-115 1816382-20 1991 The vasoconstrictor effect of KCl was paralleled by an increase of the arterio-venous difference of perfusate renin activity to such an extent that the rate of renin release remained unaltered. Potassium Chloride 30-33 renin Rattus norvegicus 160-165 1961256-3 1991 The activity of the renin-angiotensin system was modulated by varying of the nutritional sodium load prior to the experiments. Sodium 89-95 renin Rattus norvegicus 20-25 1908097-3 1991 In order to determine the relationship between active renin heterogeneity and differences in composition or attachment of oligosaccharides, two separate experiments were performed: (i) Tunicamycin, which interferes with normal glycosylation processing, increased the proportion of relatively basic renin forms secreted into the incubation media by rat renal cortical slices. Tunicamycin 185-196 renin Rattus norvegicus 298-303 1884112-3 1991 However in water-deprived (i.e. renin-dependent) Brattleboro rats, DuP 753 caused marked hypotension and regional vasodilatations. Water 11-16 renin Rattus norvegicus 32-37 1877687-7 1991 Drinking 3 mmol NaCl reliably reduced plasma aldosterone concentrations within 15 min and renin activity within 30 min. Sodium Chloride 16-20 renin Rattus norvegicus 90-95 1860717-0 1991 Heterogeneity of renin alleles in outbred Dahl salt-sensitive (Brookhaven) rats. dahl salt 42-51 renin Rattus norvegicus 17-22 1860718-7 1991 Six weeks of caffeine administration increased blood pressure, blood urea nitrogen, serum creatinine, plasma renin activity, and plasma irET-1 in the 2K1C rats but not in the sham-operated rats. Caffeine 13-21 renin Rattus norvegicus 109-114 1906538-8 1991 In pithed rats, diazoxide increased markedly plasma renin activity. Diazoxide 16-25 renin Rattus norvegicus 52-57 1708901-11 1991 Dietary NaCl restriction stimulated the expression of both genes, although the onset of renin gene activation required more prolonged sodium chloride restriction. Sodium Chloride 8-12 renin Rattus norvegicus 88-93 1708901-11 1991 Dietary NaCl restriction stimulated the expression of both genes, although the onset of renin gene activation required more prolonged sodium chloride restriction. Sodium Chloride 134-149 renin Rattus norvegicus 88-93 1823449-0 1991 Experimental evidence on pineal renin-angiotensin system as activator of serotonin and melatonin synthesis. Serotonin 73-82 renin Rattus norvegicus 32-37 1823449-0 1991 Experimental evidence on pineal renin-angiotensin system as activator of serotonin and melatonin synthesis. Melatonin 87-96 renin Rattus norvegicus 32-37 1823449-2 1991 Results are interpreted with regard to the concept of the activating role of the pineal renin-angiotensin system on the serotonin and melatonin biosynthesis. Serotonin 120-129 renin Rattus norvegicus 88-93 1823449-2 1991 Results are interpreted with regard to the concept of the activating role of the pineal renin-angiotensin system on the serotonin and melatonin biosynthesis. Melatonin 134-143 renin Rattus norvegicus 88-93 1877652-8 1991 DNX rats had a net accumulation of 2.54 meq more sodium than INN rats over 72 h. Significant inhibition of plasma renin activity within the first 24 h occurred only in rats receiving the LNa-to-HNa switch in sodium intake, and this response was not different between rats with innervated and denervated kidneys. Sodium 208-214 renin Rattus norvegicus 114-119 1719221-3 1991 In this study, we evaluated the pathophysiological role of the renin-angiotensin system in isoproterenol-induced cardiac hypertrophy, using myocardial ODC activity as an indicator of cardiac hypertrophy. Isoproterenol 91-104 renin Rattus norvegicus 63-68 1719221-6 1991 These results indicate that the renin-angiotensin system may participate in the induction of myocardial hypertrophy by isoproterenol. Isoproterenol 119-132 renin Rattus norvegicus 32-37 1827673-3 1991 The high salt group showed a lower plasma renin concentration and a higher plasma atrial natriuretic peptide (ANP) along with an attenuation of the magnitude of early hypertension, as compared with the control group. Salts 9-13 renin Rattus norvegicus 42-47 1881045-2 1991 In preliminary studies synthetic oligonucleotide primers corresponding to regions in the rat renin cDNA sequence, which are highly conserved between mouse, rat, and man, were found to yield good amplification efficiency with a rat renin cDNA template, but little product was observed with rabbit cDNA template. Oligonucleotides 33-48 renin Rattus norvegicus 93-98 1881045-2 1991 In preliminary studies synthetic oligonucleotide primers corresponding to regions in the rat renin cDNA sequence, which are highly conserved between mouse, rat, and man, were found to yield good amplification efficiency with a rat renin cDNA template, but little product was observed with rabbit cDNA template. Oligonucleotides 33-48 renin Rattus norvegicus 231-236 1896493-1 1991 Intraperitoneal application of p-chloroamphetamine (PCA) is considered a suitable probe for investigation of central serotoninergic control on renin release in the rat, although it causes several behavioral and autonomic changes including negative water balance (increased urination and loss of body weight). p-Chloroamphetamine 31-50 renin Rattus norvegicus 143-148 1896493-1 1991 Intraperitoneal application of p-chloroamphetamine (PCA) is considered a suitable probe for investigation of central serotoninergic control on renin release in the rat, although it causes several behavioral and autonomic changes including negative water balance (increased urination and loss of body weight). p-Chloroamphetamine 52-55 renin Rattus norvegicus 143-148 1827673-7 1991 These results demonstrate that high salt intake attenuates the developmental phase of hypertension in two-kidney, one-clip rats by increasing the ANP and suppressing the release of renin. Salts 36-40 renin Rattus norvegicus 181-186 2061832-4 1991 Renin granules were obtained by a modification of the sucrose gradient method, which yielded a 67-fold purification of renin granules as assessed by marker enzymes, or a modification of the Percoll gradient, which yielded a 230-fold enrichment of renin granules. Sucrose 54-61 renin Rattus norvegicus 0-5 2035656-0 1991 Protein-induced modulation of renin secretion is mediated by prostaglandins. Prostaglandins 61-75 renin Rattus norvegicus 30-35 2035656-6 1991 Changes in plasma and renal tissue renin on meclofenamate treatment were similar to those observed on 6% protein diet. Meclofenamic Acid 44-57 renin Rattus norvegicus 35-40 2035656-9 1991 This impairment in renin release is mediated by PG. Prostaglandins 48-50 renin Rattus norvegicus 19-24 2039449-6 1991 Recombinant prorenin was bound to a Cibacron Blue-Sepharose column and eluted with 1.4 M-NaCl, but was not retained by an octapeptide renin inhibitor (H-77)-Sepharose column. Cibacron Blue 36-49 renin Rattus norvegicus 15-20 2039449-6 1991 Recombinant prorenin was bound to a Cibacron Blue-Sepharose column and eluted with 1.4 M-NaCl, but was not retained by an octapeptide renin inhibitor (H-77)-Sepharose column. Sepharose 50-59 renin Rattus norvegicus 15-20 2039449-6 1991 Recombinant prorenin was bound to a Cibacron Blue-Sepharose column and eluted with 1.4 M-NaCl, but was not retained by an octapeptide renin inhibitor (H-77)-Sepharose column. Sodium Chloride 89-93 renin Rattus norvegicus 15-20 2039449-7 1991 Trypsin activation of prorenin increased the renin activity 110-fold, caused binding to an H-77-Sepharose column and nullified the reactivity to the above two kinds of anti-prosegment antibodies, findings indicating that the activation of prorenin with trypsin is due to the cleavage of the prosegment. Sepharose 96-105 renin Rattus norvegicus 25-30 1915579-4 1991 The response to angiotensinogen was small and not blocked by saralasin but the response to angiotensinogen that was mixed with renin for a few seconds was saralasin-sensitive and perindopril and CH-66 showed a tendency to block this response. Perindopril 179-190 renin Rattus norvegicus 127-132 2061832-6 1991 Granular renin content was increased by chronic sodium deprivation and hypophysectomy. Sodium 48-54 renin Rattus norvegicus 9-14 2061832-14 1991 Nigericin stimulated renin release at all pHs, but its effect required K+. Nigericin 0-9 renin Rattus norvegicus 21-26 2016314-1 1991 We isolated 7.4 mg of pure renin from 2 kg of rat kidneys using affinity chromatography on pepstatin-aminohexyl-Sepharose and an octapeptide renin inhibitor, H-77-Sepharose. h-77-sepharose 158-172 renin Rattus norvegicus 141-146 2016314-2 1991 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that renin consists of two polypeptide chains linked by a disulfide bond, one of Mr = 36,000 (heavy chain) and the other of Mr = 3,000 (light chain). Sodium Dodecyl Sulfate 0-22 renin Rattus norvegicus 70-75 2016314-2 1991 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that renin consists of two polypeptide chains linked by a disulfide bond, one of Mr = 36,000 (heavy chain) and the other of Mr = 3,000 (light chain). polyacrylamide 23-37 renin Rattus norvegicus 70-75 2016314-2 1991 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that renin consists of two polypeptide chains linked by a disulfide bond, one of Mr = 36,000 (heavy chain) and the other of Mr = 3,000 (light chain). Disulfides 123-132 renin Rattus norvegicus 70-75 1849363-5 1991 In SHR and WKY at all ages, renin responses to stimulation with isoproterenol (ISO, 10(-5) and 10(-6) M, respectively) were similar. Isoproterenol 64-77 renin Rattus norvegicus 28-33 2018117-4 1991 To test the efficacy of ET-1 as a renin inhibitor, experiments were performed in the presence of the renin stimulator isoproterenol (10(-5) M). Isoproterenol 118-131 renin Rattus norvegicus 101-106 2018117-5 1991 Addition of isoproterenol to cortical slices increased renin release by 97% (P less than 0.001); ET-1 (10(-8) M) limited this increase in renin release by isoproterenol by 80% (P less than 0.05). Isoproterenol 12-25 renin Rattus norvegicus 55-60 2018117-5 1991 Addition of isoproterenol to cortical slices increased renin release by 97% (P less than 0.001); ET-1 (10(-8) M) limited this increase in renin release by isoproterenol by 80% (P less than 0.05). Isoproterenol 155-168 renin Rattus norvegicus 138-143 2018117-7 1991 In isolated JGC, isoproterenol increased renin secretion by 151% (P less than 0.001); ET-1 (10(-8) M) significantly reduced this stimulated increase in renin secretion by 68%. Isoproterenol 17-30 renin Rattus norvegicus 41-46 2018117-8 1991 The mechanism of renin inhibition was examined by testing the effects of the intracellular calcium buffer 1,2-bis(2-aminophenoxy) ethane-N,N,N",N"-tetraacetic acid (BAPTA; 10(-6) M) in JGC. Calcium 91-98 renin Rattus norvegicus 17-22 2018117-8 1991 The mechanism of renin inhibition was examined by testing the effects of the intracellular calcium buffer 1,2-bis(2-aminophenoxy) ethane-N,N,N",N"-tetraacetic acid (BAPTA; 10(-6) M) in JGC. 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 106-163 renin Rattus norvegicus 17-22 2018117-8 1991 The mechanism of renin inhibition was examined by testing the effects of the intracellular calcium buffer 1,2-bis(2-aminophenoxy) ethane-N,N,N",N"-tetraacetic acid (BAPTA; 10(-6) M) in JGC. 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 165-170 renin Rattus norvegicus 17-22 2018117-9 1991 BAPTA alone increased renin secretion in JGC by 116% (P less than 0.01); when the combination of (10(-6) M) BAPTA and ET-1 (10(-8) M) were tested in the JGC, renin secretion still increased significantly (by 78%, P less than 0.05). 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 0-5 renin Rattus norvegicus 22-27 1674517-3 1991 In response to salt loading, plasma renin activity (PRA) and plasma aldosterone unexpectedly increased in SHR, in contrast to their decrease in the normotensive strains. Salts 15-19 renin Rattus norvegicus 36-41 2013478-4 1991 The blood pressure-lowering effect of SQ29548 in the early phase of aortic coarctation-induced hypertension was positively correlated with the prevailing plasma renin activity and could not be demonstrated in hypertensive rats pretreated with indomethacin. SQ 29548 38-45 renin Rattus norvegicus 161-166 1671866-5 1991 Compared to the saline-treated rats with UUO, renin remained localized to the juxtaglomerular region in both kidneys of rats with UUO receiving guanethidine (P less than 0.05). Sodium Chloride 16-22 renin Rattus norvegicus 46-51 1671866-5 1991 Compared to the saline-treated rats with UUO, renin remained localized to the juxtaglomerular region in both kidneys of rats with UUO receiving guanethidine (P less than 0.05). Guanethidine 144-156 renin Rattus norvegicus 46-51 1671866-6 1991 Moreover, renin mRNA levels were eightfold lower in obstructed kidneys of rats receiving guanethidine than in those receiving saline. Guanethidine 89-101 renin Rattus norvegicus 10-15 1671866-6 1991 Moreover, renin mRNA levels were eightfold lower in obstructed kidneys of rats receiving guanethidine than in those receiving saline. Sodium Chloride 126-132 renin Rattus norvegicus 10-15 2013478-0 1991 Role of prostanoids in renin-dependent and renin-independent hypertension. Prostaglandins 8-19 renin Rattus norvegicus 23-28 1999328-1 1991 It has been proposed that the initial event of sodium retention in cirrhosis is a peripheral arteriolar vasodilation causing underfilling of the arterial vascular compartment and stimulation of the renin-aldosterone and sympathetic nervous systems. Sodium 47-53 renin Rattus norvegicus 198-203 1847201-2 1991 This potentiating effect appeared to be mediated by tissue conversion of renin substrate to angiotensin II because the response 1) could be mimicked by angiotensin II, 2) was accompanied by an increase in angiotensin II production and 3) was blocked by the angiotensin converting enzyme (ACE) inhibitor quinaprilat and the angiotensin II receptor antagonist saralasin ([Sar1,Ile5,Ala8]angiotensin II). quinaprilat 303-314 renin Rattus norvegicus 73-78 2005584-0 1991 Caffeine potentiates vasodilator-induced renin release. Caffeine 0-8 renin Rattus norvegicus 41-46 2005584-2 1991 The clinical significance of this is that caffeine, a widely consumed adenosine receptor antagonist, could augment renin release responses to diseases such as renovascular hypertension, liver cirrhosis and heart failure and to therapeutic maneuvers such as salt restriction, diuretics and vasodilators. Caffeine 42-50 renin Rattus norvegicus 115-120 2005584-2 1991 The clinical significance of this is that caffeine, a widely consumed adenosine receptor antagonist, could augment renin release responses to diseases such as renovascular hypertension, liver cirrhosis and heart failure and to therapeutic maneuvers such as salt restriction, diuretics and vasodilators. Salts 257-261 renin Rattus norvegicus 115-120 2005584-3 1991 Caffeine may be particularly troublesome in this regard because this methylxanthine has central nervous system effects and intracellular actions that also might contribute to the overall ability of caffeine to potentiate renin secretion. Caffeine 0-8 renin Rattus norvegicus 221-226 2005584-3 1991 Caffeine may be particularly troublesome in this regard because this methylxanthine has central nervous system effects and intracellular actions that also might contribute to the overall ability of caffeine to potentiate renin secretion. methylxanthine 69-83 renin Rattus norvegicus 221-226 2005584-3 1991 Caffeine may be particularly troublesome in this regard because this methylxanthine has central nervous system effects and intracellular actions that also might contribute to the overall ability of caffeine to potentiate renin secretion. Caffeine 198-206 renin Rattus norvegicus 221-226 2005584-4 1991 The purpose of this study was to document the effects of caffeine on renin release responses to a vasodilator and to investigate what mechanisms were responsible for any augmentation of vasodilator-induced renin secretion. Caffeine 57-65 renin Rattus norvegicus 69-74 2005584-7 1991 Caffeine and DPSPX increased base-line plasma renin activity to a similar extent regardless of whether the animals were pretreated with propranolol. Caffeine 0-8 renin Rattus norvegicus 46-51 2005584-7 1991 Caffeine and DPSPX increased base-line plasma renin activity to a similar extent regardless of whether the animals were pretreated with propranolol. 1,3-dipropyl-8-(4-sulfophenyl)xanthine 13-18 renin Rattus norvegicus 46-51 2005584-8 1991 In rats with an intact beta adrenergic system, caffeine, but not DPSPX, increased the renin release response to low-dose hydralazine (1 mg/kg). Caffeine 47-55 renin Rattus norvegicus 86-91 2005584-8 1991 In rats with an intact beta adrenergic system, caffeine, but not DPSPX, increased the renin release response to low-dose hydralazine (1 mg/kg). Hydralazine 121-132 renin Rattus norvegicus 86-91 2005584-9 1991 Although both xanthines augmented the renin release response to high-dose hydralazine (10 mg/kg), caffeine was more efficacious in this regard. Xanthines 14-23 renin Rattus norvegicus 38-43 2005584-9 1991 Although both xanthines augmented the renin release response to high-dose hydralazine (10 mg/kg), caffeine was more efficacious in this regard. Hydralazine 74-85 renin Rattus norvegicus 38-43 2005584-11 1991 These data demonstrate that caffeine increases base-line renin release primarily by blocking peripheral (most likely renal), cell-surface adenosine receptors; however, caffeine potentiates vasodilator-induced renin secretion in part by blocking peripheral (most likely renal), cell-surface adenosine receptors and in part by additional central nervous system and/or intracellular mechanism(s) that involve the beta adrenergic system. Caffeine 28-36 renin Rattus norvegicus 57-62 2001417-0 1991 Hepatocellular uptake of peptides by bile acid transporters: relationship of carrier-mediated transport of linear peptides with renin-inhibiting activity to multispecific bile acid carriers. Bile Acids and Salts 37-46 renin Rattus norvegicus 128-133 1671595-1 1991 There are reports of an increase in renin release after the administration of fenoldopam which probably results from the activation of dopamine (DA)-1 receptors located on juxtaglomerular cells in the kidney. Fenoldopam 78-88 renin Rattus norvegicus 36-41 1671595-3 1991 In this study we have examined the effect of an increase in renin-angiotensin system activity during the administration of fenoldopam on the natriuretic and diuretic action of this compound. Fenoldopam 123-133 renin Rattus norvegicus 60-65 2005584-11 1991 These data demonstrate that caffeine increases base-line renin release primarily by blocking peripheral (most likely renal), cell-surface adenosine receptors; however, caffeine potentiates vasodilator-induced renin secretion in part by blocking peripheral (most likely renal), cell-surface adenosine receptors and in part by additional central nervous system and/or intracellular mechanism(s) that involve the beta adrenergic system. Caffeine 168-176 renin Rattus norvegicus 209-214 2024728-0 1991 The influence of the renin gene on alcohol consumption in Dahl rats. Alcohols 35-42 renin Rattus norvegicus 21-26 2024728-2 1991 Rats with a double dose of the allele--the salt-sensitive hypertensive rats--have low renin activity compared with the salt-resistant hypertensive rat that does not have this S-allele. Salts 43-47 renin Rattus norvegicus 86-91 2024728-3 1991 Alcohol consumption in rats has also been shown to vary with renin activity, and the possible involvement of renin activity in the genetics of alcohol consumption was suggested by previous work showing that the alcohol-preferring P line of selected rats had low renin levels. Alcohols 0-7 renin Rattus norvegicus 61-66 2024728-3 1991 Alcohol consumption in rats has also been shown to vary with renin activity, and the possible involvement of renin activity in the genetics of alcohol consumption was suggested by previous work showing that the alcohol-preferring P line of selected rats had low renin levels. Alcohols 143-150 renin Rattus norvegicus 109-114 2024728-3 1991 Alcohol consumption in rats has also been shown to vary with renin activity, and the possible involvement of renin activity in the genetics of alcohol consumption was suggested by previous work showing that the alcohol-preferring P line of selected rats had low renin levels. Alcohols 143-150 renin Rattus norvegicus 109-114 2024728-3 1991 Alcohol consumption in rats has also been shown to vary with renin activity, and the possible involvement of renin activity in the genetics of alcohol consumption was suggested by previous work showing that the alcohol-preferring P line of selected rats had low renin levels. Alcohols 211-218 renin Rattus norvegicus 109-114 2024728-3 1991 Alcohol consumption in rats has also been shown to vary with renin activity, and the possible involvement of renin activity in the genetics of alcohol consumption was suggested by previous work showing that the alcohol-preferring P line of selected rats had low renin levels. Alcohols 211-218 renin Rattus norvegicus 109-114 2024728-8 1991 These findings suggest that genetically mediated alterations in the renin gene may exert a significant influence on alcohol consumption and may be a component in the etiology of alcoholism. Alcohols 116-123 renin Rattus norvegicus 68-73 2020087-6 1991 Although on the normal-salt diet the blood pressure of 2K1C rats tended to correlate with plasma renin activity, on the high-salt diet plasma renin activity was markedly decreased, and then blood pressure highly correlated with sodium space. Salts 125-129 renin Rattus norvegicus 142-147 1847201-5 1991 Significant reductions in blood pressure and the potentiating effect of renin substrate on the isolated mesenteric vasculature were still observed 24 and 48 hr after the last dose of quinapril. Quinapril 183-192 renin Rattus norvegicus 72-77 2020087-7 1991 Accordingly, the lesser salt sensitivity in 2K1C rats is probably attributable to the counterbalance of the suppressed renin-angiotensin system against volume expansion. Salts 24-28 renin Rattus norvegicus 119-124 1847201-7 1991 These results suggest that the changes in tissue renin-angiotensin system, and not the circulating system, are closely related to the blood pressure lowering effect of the ACE inhibitor, quinapril. Quinapril 187-196 renin Rattus norvegicus 49-54 1921254-7 1991 An altered peripheral or central renin metabolism in this rat strain might be partly responsible for their relative lack of salt appetite and could be related to their notable lack of blood pressure sensitivity to dietary NaCl. Salts 124-128 renin Rattus norvegicus 33-38 1992779-4 1991 These results suggest that the state of low- compared to high-salt intake causes a relatively stronger activity of endogenous ET, and that the endogenous ET contributes to the adaptative modulations of sodium excretion via renal tubular action and renin release in association with the changed state of sodium balance. Salts 62-66 renin Rattus norvegicus 248-253 1760888-0 1991 Altered renin release from isolated superfused rat glomeruli in DOCA-salt hypertensive rats. Desoxycorticosterone Acetate 64-68 renin Rattus norvegicus 8-13 1760888-0 1991 Altered renin release from isolated superfused rat glomeruli in DOCA-salt hypertensive rats. Salts 69-73 renin Rattus norvegicus 8-13 1760888-1 1991 The present study was designed to clarify the role of calcium in suppressed renin release in DOCA-salt hypertension. Calcium 54-61 renin Rattus norvegicus 76-81 1760888-1 1991 The present study was designed to clarify the role of calcium in suppressed renin release in DOCA-salt hypertension. Desoxycorticosterone Acetate 93-97 renin Rattus norvegicus 76-81 1760888-1 1991 The present study was designed to clarify the role of calcium in suppressed renin release in DOCA-salt hypertension. Salts 98-102 renin Rattus norvegicus 76-81 1760888-4 1991 Basal levels of renin release were lower in the DOCA-salt hypertensive rats (1.16 +/- 0.27 ng/ATI/hr/hr/10(4) glomeruli, mean +/- SEM, n = 8) than in the control rats (1.92 +/- 0.18, p less than 0.01, n = 8). Desoxycorticosterone Acetate 48-52 renin Rattus norvegicus 16-21 1760888-4 1991 Basal levels of renin release were lower in the DOCA-salt hypertensive rats (1.16 +/- 0.27 ng/ATI/hr/hr/10(4) glomeruli, mean +/- SEM, n = 8) than in the control rats (1.92 +/- 0.18, p less than 0.01, n = 8). Salts 53-57 renin Rattus norvegicus 16-21 1760888-5 1991 Perfusion with a calcium free solution containing EGTA and A23187 stimulated renin release in the DOCA-salt hypertensive and control rats. Calcium 17-24 renin Rattus norvegicus 77-82 1760888-5 1991 Perfusion with a calcium free solution containing EGTA and A23187 stimulated renin release in the DOCA-salt hypertensive and control rats. Egtazic Acid 50-54 renin Rattus norvegicus 77-82 1760888-5 1991 Perfusion with a calcium free solution containing EGTA and A23187 stimulated renin release in the DOCA-salt hypertensive and control rats. Calcimycin 59-65 renin Rattus norvegicus 77-82 1760888-5 1991 Perfusion with a calcium free solution containing EGTA and A23187 stimulated renin release in the DOCA-salt hypertensive and control rats. Desoxycorticosterone Acetate 98-102 renin Rattus norvegicus 77-82 1760888-5 1991 Perfusion with a calcium free solution containing EGTA and A23187 stimulated renin release in the DOCA-salt hypertensive and control rats. Salts 103-107 renin Rattus norvegicus 77-82 1760888-6 1991 The maximum levels of renin release during the perfusion in DOCA-salt hypertensive rats (1.79 +/- 0.17, n = 8) were lower than those in control rats (10.60 +/- 1.85, p less than 0.01, n = 8). Desoxycorticosterone Acetate 60-64 renin Rattus norvegicus 22-27 1760888-6 1991 The maximum levels of renin release during the perfusion in DOCA-salt hypertensive rats (1.79 +/- 0.17, n = 8) were lower than those in control rats (10.60 +/- 1.85, p less than 0.01, n = 8). Salts 65-69 renin Rattus norvegicus 22-27 1715494-3 1991 Captopril was less effective in sodium chloride-induced, low-renin Dahl rat hypertension. Captopril 0-9 renin Rattus norvegicus 61-66 1715494-3 1991 Captopril was less effective in sodium chloride-induced, low-renin Dahl rat hypertension. Sodium Chloride 32-47 renin Rattus norvegicus 61-66 1761187-14 1991 However, it is uncertain whether hypothalamic norepinephrine is involved in the hypovolemic thirst mediated via stimulation of renin-angiotensin system. Norepinephrine 46-60 renin Rattus norvegicus 127-132 1725794-3 1991 Nitrendipine lowered heart weights, plasma atrial natriuretic peptide levels, and plasma renin activity, and was diuretic. Nitrendipine 0-12 renin Rattus norvegicus 89-94 1725382-12 1991 Similarly, increased plasma renin activity induced by chronic salt depletion (0% NaCl) in pithed rats provoked a shift to the right of the dose-response curves to Ang II and ET-1 but not to MTX. Salts 62-66 renin Rattus norvegicus 28-33 1725382-12 1991 Similarly, increased plasma renin activity induced by chronic salt depletion (0% NaCl) in pithed rats provoked a shift to the right of the dose-response curves to Ang II and ET-1 but not to MTX. Sodium Chloride 81-85 renin Rattus norvegicus 28-33 1921254-7 1991 An altered peripheral or central renin metabolism in this rat strain might be partly responsible for their relative lack of salt appetite and could be related to their notable lack of blood pressure sensitivity to dietary NaCl. Sodium Chloride 222-226 renin Rattus norvegicus 33-38 2260680-1 1990 We investigated the effect of angiotensin II (ANG II) and enalapril on accumulation of renin messenger RNA (mRNA) and on renal renin distribution (immunohistochemical analysis). Enalapril 58-67 renin Rattus norvegicus 87-92 1851541-3 1991 The angiotensin II precursors, angiotensin I and a synthetic tetradecapeptide renin substrate, each enhanced the stimulation-induced efflux of radioactivity from tissues previously incubated with 3H-noradrenaline. 3h-noradrenaline 196-212 renin Rattus norvegicus 78-83 1921644-0 1991 Calcium-dependent inhibition of renin secretion: TMB-8 is a non-specific antagonist. Calcium 0-7 renin Rattus norvegicus 32-37 1921644-0 1991 Calcium-dependent inhibition of renin secretion: TMB-8 is a non-specific antagonist. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 49-54 renin Rattus norvegicus 32-37 1921644-4 1991 Basal renin secretory rate was unaffected by 1 and 10 microM TMB-8, but more than doubled in response to 100 microM TMB-8. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 116-121 renin Rattus norvegicus 6-11 1921644-5 1991 Basal renin secretory rate was inhibited by A-II (1 microM), by ADH (200 units/1), by an A1-adenosine receptor agonist (N6-cyclohexyladenosine, or CHA; 0.5 microM), and by an alpha-adrenergic agonist (methoxamine; 10 microM). N(6)-cyclohexyladenosine 120-142 renin Rattus norvegicus 6-11 1921644-5 1991 Basal renin secretory rate was inhibited by A-II (1 microM), by ADH (200 units/1), by an A1-adenosine receptor agonist (N6-cyclohexyladenosine, or CHA; 0.5 microM), and by an alpha-adrenergic agonist (methoxamine; 10 microM). Methoxamine 201-212 renin Rattus norvegicus 6-11 2046802-1 1991 Puromycin aminonucleoside (PA)-nephrotic rats have a high plasma renin activity (PRA) and low angiotensinogen levels. Puromycin Aminonucleoside 0-25 renin Rattus norvegicus 65-70 2046802-1 1991 Puromycin aminonucleoside (PA)-nephrotic rats have a high plasma renin activity (PRA) and low angiotensinogen levels. Puromycin Aminonucleoside 27-29 renin Rattus norvegicus 65-70 1980994-7 1990 When treated with the nonspecific beta-adrenoceptor blocker propranolol, the elevated plasma renin activity and atrial-specific granule number in rats on a low sodium intake were significantly less. Propranolol 60-71 renin Rattus norvegicus 93-98 2260680-5 1990 Renin mRNA was identified by hybridization with a 32P-labeled full-length complementary DNA and was detected by autoradiography. Phosphorus-32 50-53 renin Rattus norvegicus 0-5 2260680-6 1990 Enalapril treatment increased renal renin mRNA specific activity (renin mRNA/total RNA). Enalapril 0-9 renin Rattus norvegicus 36-41 2260680-6 1990 Enalapril treatment increased renal renin mRNA specific activity (renin mRNA/total RNA). Enalapril 0-9 renin Rattus norvegicus 66-71 2260680-8 1990 In addition, renin immunostaining increased along the afferent arteriole after enalapril treatment; however, enalapril-induced spread of renin immunostaining was not inhibited by ANG II. Enalapril 79-88 renin Rattus norvegicus 13-18 2260680-8 1990 In addition, renin immunostaining increased along the afferent arteriole after enalapril treatment; however, enalapril-induced spread of renin immunostaining was not inhibited by ANG II. Enalapril 109-118 renin Rattus norvegicus 137-142 2260680-9 1990 Thus ANG II attenuates the accumulation of renin mRNA stimulated by enalapril treatment without alteration of renal renin distribution. Enalapril 68-77 renin Rattus norvegicus 43-48 2269396-6 1990 By immunoblotting, these antisera demonstrated rat renin to migrate on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as two broad bands of 33,000-34,000 and 35,000-37,000 Da. Sodium Dodecyl Sulfate 71-93 renin Rattus norvegicus 51-56 2260132-5 1990 The increase in calcium content of brain and kidney tissues and of plasma renin activity, urea, and creatinine was attenuated by nimodipine or parathyroidectomy. Calcium 16-23 renin Rattus norvegicus 74-79 2260132-5 1990 The increase in calcium content of brain and kidney tissues and of plasma renin activity, urea, and creatinine was attenuated by nimodipine or parathyroidectomy. Nimodipine 129-139 renin Rattus norvegicus 74-79 2281947-1 1990 Activation of the renin-angiotensin system has been shown to arouse both water and sodium intake in the rat. Water 73-78 renin Rattus norvegicus 18-23 2281947-1 1990 Activation of the renin-angiotensin system has been shown to arouse both water and sodium intake in the rat. Sodium 83-89 renin Rattus norvegicus 18-23 2281947-2 1990 The following experiments examine the contributions of the peripheral and central renin-angiotensin systems to the expression of sodium appetite in the adrenal-intact rat. Sodium 129-135 renin Rattus norvegicus 82-87 2174021-0 1990 Role of the adrenal renin-angiotensin system on adrenocorticotropic hormone- and potassium-stimulated aldosterone production by rat adrenal glomerulosa cells in monolayer culture. Potassium 81-90 renin Rattus norvegicus 20-25 2174021-0 1990 Role of the adrenal renin-angiotensin system on adrenocorticotropic hormone- and potassium-stimulated aldosterone production by rat adrenal glomerulosa cells in monolayer culture. Aldosterone 102-113 renin Rattus norvegicus 20-25 2174021-1 1990 The rat zona glomerulosa has a renin-angiotensin system that appears to function as an autocrine or paracrine system in the regulation of aldosterone production. Aldosterone 138-149 renin Rattus norvegicus 31-36 2150362-11 1990 Both the vascular renin activity and the plasma renin activity increased on captopril treatment, but their changes with time were different. Captopril 76-85 renin Rattus norvegicus 18-23 2150362-11 1990 Both the vascular renin activity and the plasma renin activity increased on captopril treatment, but their changes with time were different. Captopril 76-85 renin Rattus norvegicus 48-53 2269396-6 1990 By immunoblotting, these antisera demonstrated rat renin to migrate on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as two broad bands of 33,000-34,000 and 35,000-37,000 Da. polyacrylamide 94-108 renin Rattus norvegicus 51-56 2203682-4 1990 The direct action of the diuretics on renin-producing cells was examined in isolated glomeruli; a rise in renin release was observed with the calmodulin inhibitor trifluoperazine (10(-5) M). Trifluoperazine 163-178 renin Rattus norvegicus 38-43 2221104-2 1990 Renin mRNA distribution was assessed using in situ hybridization to a 35S-labeled 28 mer oligonucleotide complementary to rat renin mRNA. Sulfur-35 70-73 renin Rattus norvegicus 0-5 2221104-2 1990 Renin mRNA distribution was assessed using in situ hybridization to a 35S-labeled 28 mer oligonucleotide complementary to rat renin mRNA. Sulfur-35 70-73 renin Rattus norvegicus 126-131 2221104-2 1990 Renin mRNA distribution was assessed using in situ hybridization to a 35S-labeled 28 mer oligonucleotide complementary to rat renin mRNA. Oligonucleotides 89-104 renin Rattus norvegicus 0-5 2221104-2 1990 Renin mRNA distribution was assessed using in situ hybridization to a 35S-labeled 28 mer oligonucleotide complementary to rat renin mRNA. Oligonucleotides 89-104 renin Rattus norvegicus 126-131 2221104-3 1990 Whereas in control rats renin mRNA was confined to a juxtaglomerular location, in enalapril-treated rats, renin mRNA extended proximally along the length of the afferent arteriole. Enalapril 82-91 renin Rattus norvegicus 106-111 2221104-4 1990 The percent of visible afferent arteriolar length containing renin mRNA was higher in enalapril-treated (71.7 +/- 2.8%) than in control (49.6 +/- 2.1%) rats (P less than 0.0001). Enalapril 86-95 renin Rattus norvegicus 61-66 2203682-4 1990 The direct action of the diuretics on renin-producing cells was examined in isolated glomeruli; a rise in renin release was observed with the calmodulin inhibitor trifluoperazine (10(-5) M). Trifluoperazine 163-178 renin Rattus norvegicus 106-111 2203682-5 1990 Renin release in intact hydropenic rats was not altered by diuretic therapy, but furosemide increased plasma renin activity in hydropenic as well as in volume-expanded rats. Furosemide 81-91 renin Rattus norvegicus 109-114 2203682-6 1990 This demonstrates the importance of furosemide inhibition of transport in the macula densa for its renin secretory action. Furosemide 36-46 renin Rattus norvegicus 99-104 2231411-6 1990 However, melittin-stimulated renin secretion is independent of melittin-stimulated phospholipase A2 activity, arachidonic acid release, and PG synthesis, since 20 microM-quinacrine (a phospholipase A2 antagonist) and 50 microM-meclofenamate (a cyclooxygenase antagonist) antagonized basal and melittin-stimulated PGE2 synthesis but had no effects on basal or melittin-stimulated renin secretion. Meclofenamic Acid 226-240 renin Rattus norvegicus 29-34 2172369-1 1990 The region of intron A of the rat renin gene containing a unique tandemly repeated sequence was analysed in the Milan and Lyon hypertensive rat strains and their controls, and in several Sprague-Dawley rats, using an oligonucleotide probe complementary to the tandemly repeated sequence and a renin complementary DNA probe. Oligonucleotides 217-232 renin Rattus norvegicus 34-39 2203899-0 1990 Isomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid reduce renin activity and increase water and electrolyte excretion. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 11-53 renin Rattus norvegicus 61-66 2231411-6 1990 However, melittin-stimulated renin secretion is independent of melittin-stimulated phospholipase A2 activity, arachidonic acid release, and PG synthesis, since 20 microM-quinacrine (a phospholipase A2 antagonist) and 50 microM-meclofenamate (a cyclooxygenase antagonist) antagonized basal and melittin-stimulated PGE2 synthesis but had no effects on basal or melittin-stimulated renin secretion. Dinoprostone 313-317 renin Rattus norvegicus 29-34 2231411-8 1990 Furthermore, melittin-stimulated renin secretion is not produced by inhibition of protein kinase C, since an activator of protein kinase C (12-O-tetradecanoylphorbol 13-acetate, TPA), enhanced rather than antagonized melittin-stimulated renin secretion. Tetradecanoylphorbol Acetate 178-181 renin Rattus norvegicus 33-38 2203899-6 1990 Renin concentration in the venous effluent was reduced immediately by 12(R)- and 12(S)-HETE (P less than .01), to approximately half of the control value. 12(r)- 70-76 renin Rattus norvegicus 0-5 2092055-0 1990 Role of the renin-angiotensin system in the adaptation to high salt intake in immature rats. Salts 63-67 renin Rattus norvegicus 12-17 2203899-6 1990 Renin concentration in the venous effluent was reduced immediately by 12(R)- and 12(S)-HETE (P less than .01), to approximately half of the control value. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 81-91 renin Rattus norvegicus 0-5 2231411-4 1990 Either of these actions might be expected to stimulate renin secretion, since renin secretion is stimulated by arachidonic acid and by several PGs, and since renin secretion is inhibited by several activators of protein kinase C. 2. Arachidonic Acid 111-127 renin Rattus norvegicus 55-60 2231411-4 1990 Either of these actions might be expected to stimulate renin secretion, since renin secretion is stimulated by arachidonic acid and by several PGs, and since renin secretion is inhibited by several activators of protein kinase C. 2. Arachidonic Acid 111-127 renin Rattus norvegicus 78-83 2231411-4 1990 Either of these actions might be expected to stimulate renin secretion, since renin secretion is stimulated by arachidonic acid and by several PGs, and since renin secretion is inhibited by several activators of protein kinase C. 2. Arachidonic Acid 111-127 renin Rattus norvegicus 78-83 2231411-4 1990 Either of these actions might be expected to stimulate renin secretion, since renin secretion is stimulated by arachidonic acid and by several PGs, and since renin secretion is inhibited by several activators of protein kinase C. 2. Phosphatidylglycerols 143-146 renin Rattus norvegicus 55-60 2231411-4 1990 Either of these actions might be expected to stimulate renin secretion, since renin secretion is stimulated by arachidonic acid and by several PGs, and since renin secretion is inhibited by several activators of protein kinase C. 2. Phosphatidylglycerols 143-146 renin Rattus norvegicus 78-83 2231411-4 1990 Either of these actions might be expected to stimulate renin secretion, since renin secretion is stimulated by arachidonic acid and by several PGs, and since renin secretion is inhibited by several activators of protein kinase C. 2. Phosphatidylglycerols 143-146 renin Rattus norvegicus 78-83 2231411-6 1990 However, melittin-stimulated renin secretion is independent of melittin-stimulated phospholipase A2 activity, arachidonic acid release, and PG synthesis, since 20 microM-quinacrine (a phospholipase A2 antagonist) and 50 microM-meclofenamate (a cyclooxygenase antagonist) antagonized basal and melittin-stimulated PGE2 synthesis but had no effects on basal or melittin-stimulated renin secretion. Quinacrine 170-180 renin Rattus norvegicus 29-34 2148906-0 1990 Infusion of iso-rANP(1-45) or (17-45) increases plasma immunoreactive ANP and lowers plasma renin activity and aldosterone. iso-ranp 12-20 renin Rattus norvegicus 92-97 2092055-2 1990 Salt feeding induced a significant increase in plasma sodium in immature animals, and a greater suppression of the renin-angiotensin system in immature than in adult rats, although extracellular fluid volume, plasma volume and blood pressure remained unchanged. Salts 0-4 renin Rattus norvegicus 115-120 2092055-4 1990 It is concluded that (i) the renin-angiotensin system in immature rats is more responsive to a chronically increased salt intake, (ii) this greater responsiveness partly compensates for the lower natriuretic efficiency of the kidneys of immature rats, which becomes evident after reduction of renal mass, and (iii) these events bear a relation to the higher susceptibility of prepubertal rats to the hypertensive effect of a chronically increased salt intake. Salts 117-121 renin Rattus norvegicus 29-34 2092055-4 1990 It is concluded that (i) the renin-angiotensin system in immature rats is more responsive to a chronically increased salt intake, (ii) this greater responsiveness partly compensates for the lower natriuretic efficiency of the kidneys of immature rats, which becomes evident after reduction of renal mass, and (iii) these events bear a relation to the higher susceptibility of prepubertal rats to the hypertensive effect of a chronically increased salt intake. Salts 447-451 renin Rattus norvegicus 29-34 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. boc-pro-phe-n(me) 39-56 renin Rattus norvegicus 22-27 1976691-8 1990 Our findings are in contrast to a recently published study examining an RFLP of the renin gene distinguishing salt-sensitive and salt-resistant Dahl rats. Salts 110-114 renin Rattus norvegicus 84-89 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. Histidine 56-59 renin Rattus norvegicus 22-27 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. Leucine 60-63 renin Rattus norvegicus 22-27 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. chohch2 69-76 renin Rattus norvegicus 22-27 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. val-ile-amp 77-88 renin Rattus norvegicus 22-27 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. ditekiren 90-97 renin Rattus norvegicus 22-27 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. Tromethamine 185-216 renin Rattus norvegicus 22-27 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. Tromethamine 218-222 renin Rattus norvegicus 22-27 2125705-1 1990 The possible involvement of histamine (HA) in the stress-induced increase in plasma renin activity (PRA) was investigated in male rats. Histamine 28-37 renin Rattus norvegicus 84-89 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. glucosamine urea 227-243 renin Rattus norvegicus 22-27 2125705-1 1990 The possible involvement of histamine (HA) in the stress-induced increase in plasma renin activity (PRA) was investigated in male rats. Histamine 39-41 renin Rattus norvegicus 84-89 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. tham amide 278-288 renin Rattus norvegicus 22-27 2197413-1 1990 A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic moieties at either end, e.g., tris(hydroxymethyl)aminomethane (THAM) or glucosamine urea groups at the N-terminus, and the THAM amide or aminomethylpyridine N-oxide at the C-terminus. aminomethylpyridine n-oxide 292-319 renin Rattus norvegicus 22-27 2197413-2 1990 These modified analogues, with dramatically improved water solubility, all retained the potent renin inhibitory activity of U-71038 in vitro. ditekiren 124-131 renin Rattus norvegicus 95-100 2164041-2 1990 Incubation of microvessels with either vehicle (control; C) or 10(-5) M forskolin (F) in media resulted in an increase in microvessel cAMP (0.67 +/- 0.13 vs. 22 +/- 4.6 pmol/min per mg protein) (P less than 0.005) and renin released into the culture media (1,026 +/- 98 vs. 1,552 +/- 159 pg angiotensin I/h per mg protein) (P = 0.008) (C vs. F). Colforsin 72-81 renin Rattus norvegicus 218-223 2165357-4 1990 DOCA-salt rats had suppressed plasma renin activity and increased plasma ANP concentrations (408 +/- 35 vs. 133 +/- 12 pg/ml in uninephrectomized controls, P less than 0.01). Desoxycorticosterone Acetate 0-4 renin Rattus norvegicus 37-42 2165357-4 1990 DOCA-salt rats had suppressed plasma renin activity and increased plasma ANP concentrations (408 +/- 35 vs. 133 +/- 12 pg/ml in uninephrectomized controls, P less than 0.01). Salts 5-9 renin Rattus norvegicus 37-42 2118863-12 1990 Isoproterenol (10(-5)M) stimulated the release of active renin significantly (p less than 0.01 vs. control) but did not affect the release of inactive renin. Isoproterenol 0-13 renin Rattus norvegicus 57-62 2118863-13 1990 Furosemide (50 micrograms/ml) stimulated the release of active and inactive renins significantly at 20 and 40 min (p less than 0.05 vs. control) but did not affect the release of either renin at 60 min. Furosemide 0-10 renin Rattus norvegicus 76-81 2124462-2 1990 The purpose of this study was to examine the role of the renin angiotensin system (RAS) and vasopressin in the residual hypertension exhibited by LH sympathectomized rats. Luteinizing Hormone 146-148 renin Rattus norvegicus 57-62 2164041-3 1990 Renin mRNA levels in the newborn kidney microvessels increased 1.6-fold with forskolin treatment. Colforsin 77-86 renin Rattus norvegicus 0-5 2164041-5 1990 Forskolin administration resulted in an increase in the number of renin-secreting cells without changes in the amount of renin secreted by individual cells. Colforsin 0-9 renin Rattus norvegicus 66-71 2164041-6 1990 In conclusion, newborn kidney microvessels and isolated renin-releasing microvascular cells possess a functionally active adenylate cyclase whose short-term stimulation results in accumulation of cAMP, a significant increase in renin release, and an enhancement of renin gene expression. Cyclic AMP 196-200 renin Rattus norvegicus 56-61 2206912-6 1990 For instance sodium depletion increases the expression of renal angiotensinogen (as well as renin mRNA), as does high potassium intake and androgen administration. Sodium 13-19 renin Rattus norvegicus 92-97 2194033-0 1990 Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action. Water 0-5 renin Rattus norvegicus 14-19 2196401-5 1990 Oral administration of ditekiren to rats receiving human renin infusions evoked dose-dependent hypotensive responses that were greater in magnitude and longer in duration than those elicited in rats receiving hog renin infusions. ditekiren 23-32 renin Rattus norvegicus 213-218 2196401-6 1990 Observations made in the renin-infused rats reflected the results of in vitro kinetic studies that had indicated a greater binding affinity of ditekiren for human renin than for hog renin. ditekiren 143-152 renin Rattus norvegicus 25-30 2196401-6 1990 Observations made in the renin-infused rats reflected the results of in vitro kinetic studies that had indicated a greater binding affinity of ditekiren for human renin than for hog renin. ditekiren 143-152 renin Rattus norvegicus 163-168 2196401-6 1990 Observations made in the renin-infused rats reflected the results of in vitro kinetic studies that had indicated a greater binding affinity of ditekiren for human renin than for hog renin. ditekiren 143-152 renin Rattus norvegicus 163-168 1694030-0 1990 12-lipoxygenase products are potent inhibitors of prostacyclin-induced renin release. Epoprostenol 50-62 renin Rattus norvegicus 71-76 2206915-6 1990 Chemical sympathectomy by chronic guanethidine administration reduced the total renin mRNA in the obstructed kidney (determined by Northern blot analysis) and prevented the increased renin immunostaining in both kidneys. Guanethidine 34-46 renin Rattus norvegicus 80-85 1694030-3 1990 Since prostacyclin (PGI2) is a potential renin secretagogue, we studied the direct effects of 12-lipoxygenase products on prostacyclin-induced renin secretion. Epoprostenol 122-134 renin Rattus norvegicus 143-148 2206915-6 1990 Chemical sympathectomy by chronic guanethidine administration reduced the total renin mRNA in the obstructed kidney (determined by Northern blot analysis) and prevented the increased renin immunostaining in both kidneys. Guanethidine 34-46 renin Rattus norvegicus 183-188 1694030-4 1990 Treatment of rat renal cortical slices with picomolar concentrations of 12-hydroperoxyeicosatetraenoic acid (12-HPETE) and 12-HETE blocked the prostacyclin- or iloprost (an analog of PGI2)-induced renin secretion. 12-HPETE 72-107 renin Rattus norvegicus 197-202 1694030-4 1990 Treatment of rat renal cortical slices with picomolar concentrations of 12-hydroperoxyeicosatetraenoic acid (12-HPETE) and 12-HETE blocked the prostacyclin- or iloprost (an analog of PGI2)-induced renin secretion. 12-HPETE 109-117 renin Rattus norvegicus 197-202 2235295-2 1990 DOCA treatment depressed arterial plasma renin activity, expanded plasma volume by 25% and increased arterial blood pressure. Desoxycorticosterone Acetate 0-4 renin Rattus norvegicus 41-46 1694030-4 1990 Treatment of rat renal cortical slices with picomolar concentrations of 12-hydroperoxyeicosatetraenoic acid (12-HPETE) and 12-HETE blocked the prostacyclin- or iloprost (an analog of PGI2)-induced renin secretion. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 123-130 renin Rattus norvegicus 197-202 1694030-4 1990 Treatment of rat renal cortical slices with picomolar concentrations of 12-hydroperoxyeicosatetraenoic acid (12-HPETE) and 12-HETE blocked the prostacyclin- or iloprost (an analog of PGI2)-induced renin secretion. Epoprostenol 143-155 renin Rattus norvegicus 197-202 1694030-4 1990 Treatment of rat renal cortical slices with picomolar concentrations of 12-hydroperoxyeicosatetraenoic acid (12-HPETE) and 12-HETE blocked the prostacyclin- or iloprost (an analog of PGI2)-induced renin secretion. Iloprost 160-168 renin Rattus norvegicus 197-202 2194793-4 1990 The transformed line secretes an apparently fully active enzyme and responds to carbachol stimulation with a rapid release of renin activity. Carbachol 80-89 renin Rattus norvegicus 126-131 2143478-1 1990 Positive correlation between systolic blood pressure and plasma renin substrate was demonstrated in Wistar-Kyoto rats when plasma renin substrate was reduced to within a range of 18 and 88% of control values with varying amounts of ramipril. Ramipril 232-240 renin Rattus norvegicus 64-69 2195874-5 1990 Renin mRNA was localized by in situ hybridization to an oligonucleotide complementary to renin mRNA. Oligonucleotides 56-71 renin Rattus norvegicus 0-5 2189623-2 1990 Quinapril inhibits the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and lowers blood pressure in both high- and normal-renin rodent and diuretic-treated dog models of hypertension. Quinapril 0-9 renin Rattus norvegicus 166-171 1972754-4 1990 Isoproterenol-stimulated renin secretion, a measure of postsynaptic receptor function, was increased by reserpine but not denervation, which indicates that the failure to observe beta adrenoceptor up-regulation by radioligand binding studies after denervation was not an anomaly caused by loss of presynaptic receptors masking postsynaptic supersensitivity. Isoproterenol 0-13 renin Rattus norvegicus 25-30 2188756-8 1990 Perfusion of renin-immunized, salt-depleted SHR with converting enzyme inhibitor caused no further decrease in blood pressure but significantly decreased blood pressure in salt-depleted control rats. Salts 30-34 renin Rattus norvegicus 13-18 2188756-8 1990 Perfusion of renin-immunized, salt-depleted SHR with converting enzyme inhibitor caused no further decrease in blood pressure but significantly decreased blood pressure in salt-depleted control rats. Salts 172-176 renin Rattus norvegicus 13-18 2188756-12 1990 The chronic blockade of the renin-angiotensinogen reaction in renin-immunized SHR produced an almost-complete disappearance of Ang II (0.8 %/- 7 fmol/ml; control SHR, 30.6 +/- 15.7 fmol/ml) and a 50% reduction in urinary aldosterone. Aldosterone 221-232 renin Rattus norvegicus 28-33 2188756-12 1990 The chronic blockade of the renin-angiotensinogen reaction in renin-immunized SHR produced an almost-complete disappearance of Ang II (0.8 %/- 7 fmol/ml; control SHR, 30.6 +/- 15.7 fmol/ml) and a 50% reduction in urinary aldosterone. Aldosterone 221-232 renin Rattus norvegicus 62-67 2350477-7 1990 At the end of the study, serum insulin levels were not different, but plasma renin and serum glucagon levels were lower in SHR consuming the diets with high CHO concentrations. CAV protocol 157-160 renin Rattus norvegicus 77-82 2359527-6 1990 The results suggest that adrenaline secretion in response to hypoglycaemic stress in anaesthetized rats is potentiated by hypovolaemic activation of the renin-angiotensin system. Epinephrine 25-35 renin Rattus norvegicus 153-158 2152291-5 1990 In addition, important responses to exogenously added adenosine are also induced in the bronchi, urinary bladder, taenia coli, parietal cells of the stomach and renin secretion. Adenosine 54-63 renin Rattus norvegicus 161-166 2186635-1 1990 Inhibition of plasma renin activity (PRA) by saline has been shown to be related to a specific effect of chloride. Chlorides 105-113 renin Rattus norvegicus 21-26 2186635-2 1990 The purpose of this study was to test the hypothesis that inhibition of renin release by selective chloride infusion in the rat is related to increased chloride transport in the thick ascending limb of the loop of Henle (TALH). Chlorides 99-107 renin Rattus norvegicus 72-77 2186635-1 1990 Inhibition of plasma renin activity (PRA) by saline has been shown to be related to a specific effect of chloride. Sodium Chloride 45-51 renin Rattus norvegicus 21-26 2186635-2 1990 The purpose of this study was to test the hypothesis that inhibition of renin release by selective chloride infusion in the rat is related to increased chloride transport in the thick ascending limb of the loop of Henle (TALH). Chlorides 152-160 renin Rattus norvegicus 72-77 2110974-12 1990 These results indicate that the hypotensive response induced by CGP 44 099 A in sodium-depleted rats is specifically due to the renin inhibition. Sodium 80-86 renin Rattus norvegicus 128-133 2187076-1 1990 The aim of the study was to examine regional changes in sympathetic nerve activity (SNA) and baroreceptor function and arterial plasma catecholamines, arginine vasopressin (AVP) and plasma renin activity during morphine withdrawal in chloralose-anesthetized rats. Morphine 211-219 renin Rattus norvegicus 189-194 2139332-3 1990 When glomeruli were incubated in a calcium free medium containing 2 mM EGTA, ANP suppressed stimulated renin release significantly at 5 x 10(-8) and 5 x 10(-9) M by 25% (p = 0.0204, and p = 0.0101, respectively). Egtazic Acid 71-75 renin Rattus norvegicus 103-108 2187076-12 1990 AVP increased about 15-fold, whereas plasma renin activity showed only a minor increase after naloxone. Naloxone 94-102 renin Rattus norvegicus 44-49 2139332-4 1990 These results indicate that ANP suppresses renin release in a dose dependent manner, probably through a calcium independent process. Calcium 104-111 renin Rattus norvegicus 43-48 2331021-2 1990 Chloride depletion produced the most significant increase in plasma renin activity and extracellular fluid volume contraction. Chlorides 0-8 renin Rattus norvegicus 68-73 2331021-9 1990 These results suggest different roles for sodium and chloride in the regulation of the peripheral and central renin-angiotensin system in young rats. Sodium 42-48 renin Rattus norvegicus 110-115 2158196-0 1990 Effects of angiotensin II, ACTH, and KCl on the adrenal renin-angiotensin system in the rat. Potassium Chloride 37-40 renin Rattus norvegicus 56-61 2331021-9 1990 These results suggest different roles for sodium and chloride in the regulation of the peripheral and central renin-angiotensin system in young rats. Chlorides 53-61 renin Rattus norvegicus 110-115 2187092-4 1990 Renin secretion was lower in Hypox than in normal and sodium (Na) deprived rats. Sodium 54-60 renin Rattus norvegicus 0-5 2184915-2 1990 Moderate sodium depletion (0.05% sodium in diet) significantly impaired growth rate and stimulated the renin-angiotensin system, but did not result in significant changes in peripheral or central angiotensin II receptors. Sodium 9-15 renin Rattus norvegicus 103-108 2184915-2 1990 Moderate sodium depletion (0.05% sodium in diet) significantly impaired growth rate and stimulated the renin-angiotensin system, but did not result in significant changes in peripheral or central angiotensin II receptors. Sodium 33-39 renin Rattus norvegicus 103-108 2184915-3 1990 In young rats, the impairment of the growth rate and the stimulation of the peripheral renin-angiotensin system were more notable after profound sodium depletion (0.005% sodium in diet). Sodium 145-151 renin Rattus norvegicus 87-92 2184915-3 1990 In young rats, the impairment of the growth rate and the stimulation of the peripheral renin-angiotensin system were more notable after profound sodium depletion (0.005% sodium in diet). Sodium 170-176 renin Rattus norvegicus 87-92 2267444-6 1990 Renal renin content (RRC) and isoproterenol-induced renin secretion (RS) also were studied. Isoproterenol 30-43 renin Rattus norvegicus 52-57 2158196-4 1990 In contrast, rats treated with ACTH (Cortrosyn-Z, 3 IU/day, sc) showed an increase in adrenal renin-like activity (p less than 0.01), but no significant change in adrenal angiotensin II/III immunoreactivity. cortrosyn-z 37-48 renin Rattus norvegicus 94-99 2158196-5 1990 Rats treated with KCl in drinking water showed increases (p less than 0.05) in adrenal renin-like activity, adrenal angiotensin II/III immunoreactivity, and plasma aldosterone. Potassium Chloride 18-21 renin Rattus norvegicus 87-92 2158196-5 1990 Rats treated with KCl in drinking water showed increases (p less than 0.05) in adrenal renin-like activity, adrenal angiotensin II/III immunoreactivity, and plasma aldosterone. Drinking Water 25-39 renin Rattus norvegicus 87-92 2188897-5 1990 These data suggest that elevated serum ACE and plasma renin activity, commonly found in the streptozotocin-diabetic rat, may not be primarily responsible for hypertension in this model. Streptozocin 92-106 renin Rattus norvegicus 54-59 2154933-0 1990 Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices. 14,15-epoxy-5,8,11-eicosatrienoic acid 31-61 renin Rattus norvegicus 14-19 2407369-0 1990 Endogenous adenosine restrains renin release in conscious rats. Adenosine 11-20 renin Rattus norvegicus 31-36 2407369-1 1990 The purpose of this study was to test the hypothesis that endogenous adenosine functions to restrain the renin release response to pharmacological and pathophysiological stimuli. Adenosine 69-78 renin Rattus norvegicus 105-110 2407369-2 1990 To achieve this objective, we examined the effects of an adenosine receptor antagonist, 1,3-dipropyl-8-(p-sulfophenyl)xanthine (DPSPX), on the renin release response induced by acute administration of hydralazine or by chronic clipping of the left renal artery (renovascular hypertensive rats). 1,3-dipropyl-8-(4-sulfophenyl)xanthine 88-126 renin Rattus norvegicus 143-148 2407369-2 1990 To achieve this objective, we examined the effects of an adenosine receptor antagonist, 1,3-dipropyl-8-(p-sulfophenyl)xanthine (DPSPX), on the renin release response induced by acute administration of hydralazine or by chronic clipping of the left renal artery (renovascular hypertensive rats). 1,3-dipropyl-8-(4-sulfophenyl)xanthine 128-133 renin Rattus norvegicus 143-148 2407369-10 1990 2) Even under basal physiological conditions, endogenous adenosine tonically inhibits renin release. Adenosine 57-66 renin Rattus norvegicus 86-91 2407369-12 1990 4) Endogenous adenosine negatively modulates renin release by a direct effect on juxtaglomerular cells. Adenosine 14-23 renin Rattus norvegicus 45-50 2406201-5 1990 After 8 weeks, plasma renin activity was significantly increased only in the high NaCl group (13.7 +/- 3.7 ng/ml/hr), and by 12 weeks plasma renin activity was significantly higher in the high NaCl group (25.3 +/- 3.6 ng/ml/hr) than in the high NaCl/high potassium (11.1 +/- 2.9 ng/ml/hr) or in the regular diet (7.8 +/- 4.6 ng/ml/hr) groups. Sodium Chloride 193-197 renin Rattus norvegicus 141-146 2406201-5 1990 After 8 weeks, plasma renin activity was significantly increased only in the high NaCl group (13.7 +/- 3.7 ng/ml/hr), and by 12 weeks plasma renin activity was significantly higher in the high NaCl group (25.3 +/- 3.6 ng/ml/hr) than in the high NaCl/high potassium (11.1 +/- 2.9 ng/ml/hr) or in the regular diet (7.8 +/- 4.6 ng/ml/hr) groups. Sodium Chloride 193-197 renin Rattus norvegicus 141-146 2157996-6 1990 Injection of 6-OHDa into the PVN prevented the stress-induced increase in plasma renin activity (PRA), plasma renin concentration (PRC) and plasma corticosterone concentration, suggesting that intact catecholaminergic innervation of neurons in the PVN is necessary for the stress-induced increase in renin and corticosterone secretion. Oxidopamine 13-19 renin Rattus norvegicus 81-86 2157996-6 1990 Injection of 6-OHDa into the PVN prevented the stress-induced increase in plasma renin activity (PRA), plasma renin concentration (PRC) and plasma corticosterone concentration, suggesting that intact catecholaminergic innervation of neurons in the PVN is necessary for the stress-induced increase in renin and corticosterone secretion. Oxidopamine 13-19 renin Rattus norvegicus 110-115 2157996-6 1990 Injection of 6-OHDa into the PVN prevented the stress-induced increase in plasma renin activity (PRA), plasma renin concentration (PRC) and plasma corticosterone concentration, suggesting that intact catecholaminergic innervation of neurons in the PVN is necessary for the stress-induced increase in renin and corticosterone secretion. Oxidopamine 13-19 renin Rattus norvegicus 110-115 2178451-9 1990 We conclude that exchange transfusion with saline leads to an augmented renin response to hemorrhage in part due to a decrease in arterial pH and more severe hypotension. Sodium Chloride 43-49 renin Rattus norvegicus 72-77 2154933-1 1990 The effects of products of the cytochrome P-450 epoxygenase pathway of arachidonate metabolism on renin have not been previously examined. Arachidonic Acid 71-83 renin Rattus norvegicus 98-103 2154933-4 1990 ISO increased renin release significantly (169%, P less than 0.01) in all incubations; 14,15-EET (10(-6) M) significantly reduced this increase in stimulated renin release to 47%. Isoproterenol 0-3 renin Rattus norvegicus 14-19 2154933-4 1990 ISO increased renin release significantly (169%, P less than 0.01) in all incubations; 14,15-EET (10(-6) M) significantly reduced this increase in stimulated renin release to 47%. 14,15-epoxy-5,8,11-eicosatrienoic acid 87-96 renin Rattus norvegicus 158-163 2154933-12 1990 These studies document the synthesis of EETs in rat kidney and demonstrate a direct effect of the 14,15-EET to inhibit stimulated renin release. 14,15-epoxy-5,8,11-eicosatrienoic acid 98-107 renin Rattus norvegicus 130-135 2200659-2 1990 Basal plasma renin activity (PRA) was undetectable in the nephrectomized group and suppressed in the DOCA/salt treated rats, but was increased in the rats treated with glucocorticoid. Desoxycorticosterone Acetate 101-105 renin Rattus norvegicus 13-18 2200659-2 1990 Basal plasma renin activity (PRA) was undetectable in the nephrectomized group and suppressed in the DOCA/salt treated rats, but was increased in the rats treated with glucocorticoid. Salts 106-110 renin Rattus norvegicus 13-18 2303281-8 1990 At 60 weeks of age, rats that received perinatal low salt diet had significantly heavier adrenal glands when compared with the other groups, and the high potassium group had significantly elevated plasma renin concentrations. Potassium 154-163 renin Rattus norvegicus 204-209 2166655-5 1990 These results suggest a possible role for adrenal renin in the mechanism underlying the inhibitory effect of ANP on aldosterone production in vivo. Aldosterone 116-127 renin Rattus norvegicus 50-55 2196129-1 1990 Previous investigations have shown that depletion of brain norepinephrine (NE) induced by chemical sympathectomy resulted in significant changes in the central renin-angiotensin system. Norepinephrine 59-73 renin Rattus norvegicus 160-165 2404859-16 1990 On the other hand, the peripheral renin-angiotensin system might participate in the development of high blood pressure in serotonin-depleted animals. Serotonin 122-131 renin Rattus norvegicus 34-39 2151605-1 1990 Brain serotonin depletion induced by peripheral parachlorophenylalanine (pCPA) is frequently used to evaluate the role of the central serotoninergic system in the regulation of a number of physiological functions, including the secretion of renin by the kidney. Serotonin 6-15 renin Rattus norvegicus 241-246 2151605-1 1990 Brain serotonin depletion induced by peripheral parachlorophenylalanine (pCPA) is frequently used to evaluate the role of the central serotoninergic system in the regulation of a number of physiological functions, including the secretion of renin by the kidney. Fenclonine 48-71 renin Rattus norvegicus 241-246 2151605-1 1990 Brain serotonin depletion induced by peripheral parachlorophenylalanine (pCPA) is frequently used to evaluate the role of the central serotoninergic system in the regulation of a number of physiological functions, including the secretion of renin by the kidney. Fenclonine 73-77 renin Rattus norvegicus 241-246 2405715-4 1990 Similar results were obtained when the renin-angiotensin system was blocked with the converting-enzyme inhibitor captopril. Captopril 113-122 renin Rattus norvegicus 39-44 2405715-7 1990 These results demonstrate that endogenous angiotensin II is capable of providing a positive modulatory influence on neurally mediated release of adrenal epinephrine, an effect that may require a chronic activation of the renin-angiotensin system as occurs naturally with restricted dietary sodium intake. Epinephrine 153-164 renin Rattus norvegicus 221-226 2405715-7 1990 These results demonstrate that endogenous angiotensin II is capable of providing a positive modulatory influence on neurally mediated release of adrenal epinephrine, an effect that may require a chronic activation of the renin-angiotensin system as occurs naturally with restricted dietary sodium intake. Sodium 290-296 renin Rattus norvegicus 221-226 2081373-4 1990 Similarly, inactive renin decreased (p less than 0.01) from 0.50 GU/l (range 0.28-0.67 GU/l) to 0.30 GU/l (range 0.19-0.47 GU/l) during treatment with the anti-androgen flutamide (n = 10). Flutamide 169-178 renin Rattus norvegicus 20-25 2179606-1 1990 We studied the expression of angiotensinogen and renin genes in rats treated with 3,3",5-triiodo-L-thyronine (T3) at doses of 0.1 and 1 mg/kg of body weight. 3,3",5-triiodo-l-thyronine 82-108 renin Rattus norvegicus 49-54 2179606-1 1990 We studied the expression of angiotensinogen and renin genes in rats treated with 3,3",5-triiodo-L-thyronine (T3) at doses of 0.1 and 1 mg/kg of body weight. Triiodothyronine 110-112 renin Rattus norvegicus 49-54 2352361-9 1990 In addition, it has been suggested that prostaglandins are also capable of modulating the response only in the presence of the renin-angiotensin system. Prostaglandins 40-54 renin Rattus norvegicus 127-132 2405694-5 1990 Four hours after treatment with a single dose of enalapril (3 mg/kg po), angiotensinogen mRNA level in the liver decreased by 50%, and renin mRNA level in the kidney increased 1.5-fold to the control level. Enalapril 49-58 renin Rattus norvegicus 135-140 2163483-0 1990 Vanadate-induced inhibition of renin secretion is unrelated to inhibition Na,K-ATPase activity. Vanadates 0-8 renin Rattus norvegicus 31-36 2104586-6 1990 A cyclooxygenase (CO) blocker, meclofenamate (M), which does not significantly alter basal renin release, attenuated the TNF- and rhIL-1 beta-induced renin secretion [TNF (20 U/ml), 132 +/- 11%; TNF plus M (5 X 10(-5) M), 100 +/- 3% (P less than 0.01); rhIL-1 beta (10 U/ml), 135 +/- 9%; rhIL-1 beta plus M, 105 +/- 10% (P less than 0.05)]. Meclofenamic Acid 31-44 renin Rattus norvegicus 150-155 2104586-9 1990 Since the effect of TNF and IL-1 on renin can be blocked by a (CO) inhibitor, the studies indicate a role of prostaglandins in their action. Prostaglandins 109-123 renin Rattus norvegicus 36-41 2073934-6 1990 These observations, combined with previous studies of the role of central angiotensin II and central prostanoids in the physiological control of vasopressin release, suggest that there may be important interactions between brain prostanoids and the brain renin-angiotensin system in this control. Prostaglandins 101-112 renin Rattus norvegicus 255-260 1688963-0 1990 Quipazine increases renin release by a peripheral hemodynamic mechanism. Quipazine 0-9 renin Rattus norvegicus 20-25 1688963-1 1990 Systemically administered serotonin (5-HT) agonists have been suggested to act centrally to increase plasma renin activity (PRA) and arterial pressure (AP). Serotonin 26-35 renin Rattus norvegicus 108-113 2137178-0 1990 Atrial natriuretic peptide, arginine vasopressin, aldosterone and plasma renin activity in carbon tetrachloride-induced cirrhosis in rats. Carbon Tetrachloride 91-111 renin Rattus norvegicus 73-78 2250570-1 1990 These experiments were designed to test the hypothesis that cyclosporine A (CSA) inhibits renin secretion and stimulates renal prostaglandin E2 (PGE2) release in vitro. Cyclosporine 60-74 renin Rattus norvegicus 90-95 2184050-1 1990 Nifedipine and verapamil (10 mg/kg orally) were found to induce a significant increase of renin activity, a decrease of aldosterone and ionized calcium levels in blood plasma in spontaneously hypertensive rats. Nifedipine 0-10 renin Rattus norvegicus 90-95 2184050-1 1990 Nifedipine and verapamil (10 mg/kg orally) were found to induce a significant increase of renin activity, a decrease of aldosterone and ionized calcium levels in blood plasma in spontaneously hypertensive rats. Verapamil 15-24 renin Rattus norvegicus 90-95 2184050-2 1990 A preliminary administration of a hypertonic solution of sodium chloride decreased renin activity, ionized calcium and aldosterone levels that contributed to the enhancement of the hypotensive effect of calcium antagonists. Sodium Chloride 57-72 renin Rattus norvegicus 83-88 2184050-2 1990 A preliminary administration of a hypertonic solution of sodium chloride decreased renin activity, ionized calcium and aldosterone levels that contributed to the enhancement of the hypotensive effect of calcium antagonists. Calcium 203-210 renin Rattus norvegicus 83-88 2184050-3 1990 It was established that nifedipine by its effect on the parameters of hemodynamics and the condition of renin-angiotensin system as well as the blood plasma ionized calcium level is superior to verapamil. Nifedipine 24-34 renin Rattus norvegicus 104-109 1688963-13 1990 In contrast, the peripheral 5-HT2 antagonist xylamidine blocked the renin and RBF responses, but only attenuated the pressor response to quipazine. xylamidine 45-55 renin Rattus norvegicus 68-73 2175824-0 1990 Pharmacological evidence for involvement of the sympathetic nervous system in the increase in renin secretion produced by a low sodium diet in rats. Sodium 128-134 renin Rattus norvegicus 94-99 2175824-1 1990 To determine the degree to which increased sympathetic activity contributes to the increase in renin secretion produced by a low sodium diet, the beta-adrenergic blocking drug propranolol or saline vehicle was injected through indwelling jugular cannulas in rats fed a normal diet and rats fed a low sodium diet for 9 days. Sodium 129-135 renin Rattus norvegicus 95-100 2175824-1 1990 To determine the degree to which increased sympathetic activity contributes to the increase in renin secretion produced by a low sodium diet, the beta-adrenergic blocking drug propranolol or saline vehicle was injected through indwelling jugular cannulas in rats fed a normal diet and rats fed a low sodium diet for 9 days. Propranolol 176-187 renin Rattus norvegicus 95-100 2175824-6 1990 The results indicate that increased sympathetic activity makes a substantial contribution to the increase in renin secretion produced by 9 days of dietary sodium restriction. Sodium 155-161 renin Rattus norvegicus 109-114 2250570-1 1990 These experiments were designed to test the hypothesis that cyclosporine A (CSA) inhibits renin secretion and stimulates renal prostaglandin E2 (PGE2) release in vitro. Cyclosporine 76-79 renin Rattus norvegicus 90-95 2250570-7 1990 These results suggest that the occasional effects of CSA on renin secretion in intact animals must be attributable to indirect and/or chronic effects. Cyclosporine 53-56 renin Rattus norvegicus 60-65 2250579-0 1990 Prazosin unmasks a renin response to intravenous para-chloroamphetamine. Prazosin 0-8 renin Rattus norvegicus 19-24 2250579-0 1990 Prazosin unmasks a renin response to intravenous para-chloroamphetamine. p-Chloroamphetamine 49-71 renin Rattus norvegicus 19-24 2250579-1 1990 When injected intraperitoneally, p-chloroamphetamine (PCA) causes the acute release of catecholamines and serotonin, increases mean arterial pressure (MAP) and increases plasma renin activity (PRA) in rats. p-Chloroamphetamine 33-52 renin Rattus norvegicus 177-182 2250579-1 1990 When injected intraperitoneally, p-chloroamphetamine (PCA) causes the acute release of catecholamines and serotonin, increases mean arterial pressure (MAP) and increases plasma renin activity (PRA) in rats. p-Chloroamphetamine 54-57 renin Rattus norvegicus 177-182 2163483-2 1990 In the present experiments, the rat renal cortical slice preparation was used to compare and contrast the effects of ouabain, of K-free fluid, and of vanadate on renin secretion, in the absence and presence of methoxyverapamil, a Ca channel blocker. Vanadates 150-158 renin Rattus norvegicus 162-167 2163483-6 1990 Collectively, these observations demonstrate that vanadate-induced inhibition of renin secretion cannot be attributed entirely to Na,K-ATPase inhibition, since in the presence of methoxyverapamil, the effect of vanadate differed from the effects of either ouabain (a specific Na,K-ATPase inhibitor) or K-free fluid. Vanadates 50-58 renin Rattus norvegicus 81-86 2163483-7 1990 Moreover, it cannot be attributed entirely to a depolarization-induced influx of Ca2+ through potential-operated Ca channels, since methoxyverapamil antagonized K-depolarization-induced inhibition of renin secretion much more effectively than it antagonized vanadate-induced inhibition. Gallopamil 132-148 renin Rattus norvegicus 200-205 34859416-8 2021 In particular, phosphorylation of threonine-788/789 was negatively correlated with the expression of renin. Threonine 34-43 renin Rattus norvegicus 101-106 2217270-0 1990 Circannual rhythm in response of renin release to calcium deprivation in isolated rat glomeruli. Calcium 50-57 renin Rattus norvegicus 33-38 2236972-2 1990 The role of proteinuria, hypoproteinemia, and renin-angiotensin-aldosterone system on sodium retention. Sodium 86-92 renin Rattus norvegicus 46-51 29614026-10 2018 The protective effects of prenatal metformin therapy on HFR/HFA-induced hypertension, including downregulation of the renin-angiotensin system, decrease in uric acid level, and reduction of oxidative stress. Metformin 35-44 renin Rattus norvegicus 118-123 8418022-0 1993 Time course of stimulation of renal renin messenger RNA by furosemide. Furosemide 59-69 renin Rattus norvegicus 36-41 8418022-3 1993 In the first series, Sprague-Dawley rats received furosemide (10 mg/kg) intraperitoneally and a low sodium diet (0.05% sodium); renin secretion was significantly stimulated at 8 or 16 hours after treatment, but renin mRNA levels did not change. Furosemide 50-60 renin Rattus norvegicus 128-133 8418022-6 1993 In additional animals, the response of renin mRNA 4 hours after furosemide was found not to be potentiated by the converting enzyme inhibitor quinapril (5 mg/kg). Furosemide 64-74 renin Rattus norvegicus 39-44 34419631-3 2021 For instance, alcohol intake stimulates central and peripheral renin-angiotensin system and increases angiotensin II levels, which predominantly affect angiotensin 1 receptors both in periphery and brain. Alcohols 14-21 renin Rattus norvegicus 63-68 34521155-3 2021 Recent studies have described counterregulatory interactions between renin-angiotensin system (RAS) and dopamine in peripheral tissues and in the nigro-striatal system. Dopamine 104-112 renin Rattus norvegicus 69-74 34821697-1 2021 Vitamin D secosteroids are intranuclear regulators of cellular growth and suppress the renin-angiotensin system. Vitamin D 0-9 renin Rattus norvegicus 87-92 34565105-0 2021 Histone deacetylase inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system activity in rats with transverse aortic constriction-induced pressure overload cardiac hypertrophy. mocetinostat 31-43 renin Rattus norvegicus 79-84 34226610-7 2021 At the end of the study, STZ-induced rats showed increased prorenin, renin, and angiotensin (Ang) II in the renal inner medulla and urine, along with augmented downstream fibrotic factors TGF-beta, collagen I, and fibronectin. Streptozocin 25-28 renin Rattus norvegicus 69-74 34484563-9 2021 Taurine reduced the renin, angiotensin II, and aldosterone contents and the levels of oxidative stress indices in Dahl rat renal tissues but increased antioxidant capacity, antioxidant enzyme activity, and protein expression. Taurine 0-7 renin Rattus norvegicus 20-25 34484563-11 2021 Pretreatment with the CBS inhibitor HA or renal CBS knockdown inhibited H2S generation and subsequently blocked the effect of taurine on renin, superoxide dismutase 1 (SOD1), and superoxide dismutase 2 (SOD2) levels in high-salt-stimulated Dahl renal slices. Taurine 126-133 renin Rattus norvegicus 137-142 34259014-0 2021 High Fructose-Induced Hypertension and Renal Damage Are Exaggerated in Dahl Salt-Sensitive Rats via Renal Renin-Angiotensin System Activation. Salts 76-80 renin Rattus norvegicus 106-111 34578849-6 2021 These data demonstrate that DOX through direct effects on gut microbiota and its non-microbial effects (anti-inflammatory and immunomodulatory) reduces endothelial dysfunction and the increase in blood pressure in this low-renin form of hypertension. Doxycycline 28-31 renin Rattus norvegicus 223-228 34145943-5 2021 The findings were (i) lateralized expression of the RAS genes Ace, Agtr2 and Ren with higher levels on the left side; (ii) the asymmetry in coordination of the RAS gene expression that was stronger on the right side; (iii) the decay in coordination of co-expression of the RAS and neuroplasticity-related genes induced by the right side but not left side sham surgery and UBI; and (iv) the UBI-induced shift to negative regulatory interactions between RAS and neuroplasticity-related genes on the contralesional spinal side. ubi 390-393 renin Rattus norvegicus 77-80 35197849-9 2021 Moreover, sacubitril/valsartan therapy increased plasma renin and did not prevent HSD-induced increases in renal angiotensin II, while sacubitril/C21 completely prevented these changes. sacubitril and valsartan sodium hydrate drug combination 10-20 renin Rattus norvegicus 56-61 35197849-9 2021 Moreover, sacubitril/valsartan therapy increased plasma renin and did not prevent HSD-induced increases in renal angiotensin II, while sacubitril/C21 completely prevented these changes. Valsartan 21-30 renin Rattus norvegicus 56-61 35325072-5 2022 Further inspection of the spatial gene expression data allowed us to identify the upregulation of genes involved in the renin regulating pathway in losartan-treated populations. Losartan 148-156 renin Rattus norvegicus 120-125 35325072-6 2022 Losartan is an angiotensin II receptor antagonist drug, and the observed upregulation of the renin pathway-related genes could be due to feedback from the hypotensive action of the drug. Losartan 0-8 renin Rattus norvegicus 93-98