PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 28466571-6 2017 This novel synthetic strategy is ideally suited for peptides such as relaxin and insulin-like peptide 5 as they possess methionine and tryptophan that are labile under strong oxidative conditions. Methionine 120-130 insulin like 6 Homo sapiens 81-103 28466571-6 2017 This novel synthetic strategy is ideally suited for peptides such as relaxin and insulin-like peptide 5 as they possess methionine and tryptophan that are labile under strong oxidative conditions. Tryptophan 135-145 insulin like 6 Homo sapiens 81-103 27259101-1 2016 Human insulin-like peptide-6 (INSL-6) belongs to the insulin superfamily and shares the distinctive disulfide bond configuration of human insulin. Disulfides 100-109 insulin like 6 Homo sapiens 6-28 27259101-1 2016 Human insulin-like peptide-6 (INSL-6) belongs to the insulin superfamily and shares the distinctive disulfide bond configuration of human insulin. Disulfides 100-109 insulin like 6 Homo sapiens 30-36 27259101-2 2016 In this report we present the first chemical synthesis of INSL-6 utilizing fluorenylmethyloxycarbonyl-based (Fmoc) solid-phase peptide chemistry and regioselective disulfide bond construction protocols. fluorenylmethyloxycarbonyl- 75-102 insulin like 6 Homo sapiens 58-64 27259101-2 2016 In this report we present the first chemical synthesis of INSL-6 utilizing fluorenylmethyloxycarbonyl-based (Fmoc) solid-phase peptide chemistry and regioselective disulfide bond construction protocols. Disulfides 164-173 insulin like 6 Homo sapiens 58-64 27259101-5 2016 The methodologies presented here offer an efficient synthetic route to INSL-6 and will further improve synthetic access to other multiple-disulfide-containing peptides with oxidation-sensitive residues. Disulfides 138-147 insulin like 6 Homo sapiens 71-77 25161767-9 2014 In cultured cells, Insl6 inhibits Jurkat cell proliferation and activation in response to phytohemagglutinin/phorbol 12-myristate 13-acetate stimulation. Tetradecanoylphorbol Acetate 109-140 insulin like 6 Homo sapiens 19-24 10819760-1 2000 A new member of the insulin gene family (INSL6) was identified from an Expressed Sequence Tag database through a search for proteins containing the insulin family B-chain cysteine motif. Cysteine 171-179 insulin like 6 Homo sapiens 41-46 24802387-8 2014 To test this hypothesis, we replaced the conserved B23Gly-B24Gly dipeptide of relaxin-3 with an Ala-Ser dipeptide that occupied the corresponding position of insulin-like peptide 5 and resulted in an extended helical conformation. Ala-Ser 96-103 insulin like 6 Homo sapiens 158-180 24802387-8 2014 To test this hypothesis, we replaced the conserved B23Gly-B24Gly dipeptide of relaxin-3 with an Ala-Ser dipeptide that occupied the corresponding position of insulin-like peptide 5 and resulted in an extended helical conformation. Dipeptides 104-113 insulin like 6 Homo sapiens 158-180