PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
10222149-8	1999	Wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3-K), blocked MSP-dependent adhesion, which shows that PI3-K is in the MSP-induced adhesion pathway.	Wortmannin	0-10	macrophage stimulating 1	Homo sapiens	75-78
10678267-7	2000	During MST-1, norepinephrine increased by 461 +/-165 pmol/L (mean +/- SEM) and epinephrine by 218 +/- 76 pmol/L.	Norepinephrine	14-28	macrophage stimulating 1	Homo sapiens	7-12
10574973-0	1999	Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis.	Diphosphonates	0-15	macrophage stimulating 1	Homo sapiens	77-81
10574973-7	1999	Withdrawal of serum and of macrophage colony stimulating factor, necessary for survival of purified osteoclasts, or treatment with staurosporine also induce apoptosis and caspase cleavage of Mst1.	Staurosporine	131-144	macrophage stimulating 1	Homo sapiens	191-195
10574973-8	1999	Consistent with their inhibition of the mevalonate pathway, apoptosis and cleavage of Mst1 kinase induced by alendronate, risedronate, and lovastatin, but not clodronate, are blocked by geranylgeraniol, a precursor of geranylgeranyl diphosphate.	Alendronate	109-120	macrophage stimulating 1	Homo sapiens	86-90
10574973-8	1999	Consistent with their inhibition of the mevalonate pathway, apoptosis and cleavage of Mst1 kinase induced by alendronate, risedronate, and lovastatin, but not clodronate, are blocked by geranylgeraniol, a precursor of geranylgeranyl diphosphate.	Risedronic Acid	122-133	macrophage stimulating 1	Homo sapiens	86-90
10574973-8	1999	Consistent with their inhibition of the mevalonate pathway, apoptosis and cleavage of Mst1 kinase induced by alendronate, risedronate, and lovastatin, but not clodronate, are blocked by geranylgeraniol, a precursor of geranylgeranyl diphosphate.	Lovastatin	139-149	macrophage stimulating 1	Homo sapiens	86-90
10574973-8	1999	Consistent with their inhibition of the mevalonate pathway, apoptosis and cleavage of Mst1 kinase induced by alendronate, risedronate, and lovastatin, but not clodronate, are blocked by geranylgeraniol, a precursor of geranylgeranyl diphosphate.	geranylgeraniol	186-201	macrophage stimulating 1	Homo sapiens	86-90
10574973-8	1999	Consistent with their inhibition of the mevalonate pathway, apoptosis and cleavage of Mst1 kinase induced by alendronate, risedronate, and lovastatin, but not clodronate, are blocked by geranylgeraniol, a precursor of geranylgeranyl diphosphate.	geranylgeranyl pyrophosphate	218-244	macrophage stimulating 1	Homo sapiens	86-90
10514476-8	1999	A double mutation of Asn(682)/Glu(648) caused diminished binding of the beta chain to the MSP receptor, and a single mutation of neighboring Arg(683) completely abolished binding.	Asparagine	21-24	macrophage stimulating 1	Homo sapiens	90-93
10514476-8	1999	A double mutation of Asn(682)/Glu(648) caused diminished binding of the beta chain to the MSP receptor, and a single mutation of neighboring Arg(683) completely abolished binding.	Glutamic Acid	30-33	macrophage stimulating 1	Homo sapiens	90-93
10222149-8	1999	Wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3-K), blocked MSP-dependent adhesion, which shows that PI3-K is in the MSP-induced adhesion pathway.	Wortmannin	0-10	macrophage stimulating 1	Homo sapiens	132-135
10222149-10	1999	Although MSP caused PI3-K-independent tyrosine phosphorylation and activation of FAK, experiments with dominant-negative FAK constructs showed that FAK does not mediate the effects of MSP on cell adhesion or motility.	Tyrosine	38-46	macrophage stimulating 1	Homo sapiens	9-12
8950984-5	1996	In addition to activation and phosphorylation of RON, MSP also induced tyrosine phosphorylation of the PI-3 kinase p85 subunit in a time-dependent manner, with a peak at 15 min.	Tyrosine	71-79	macrophage stimulating 1	Homo sapiens	54-57
9545236-2	1998	In this paper we show that Mst1 is specifically cleaved by a caspase 3-like activity during apoptosis induced by either cross-linking CD95/Fas or by staurosporine treatment.	Staurosporine	149-162	macrophage stimulating 1	Homo sapiens	27-31
9545236-3	1998	CD95/Fas-induced cleavage of Mst1 was blocked by the cysteine protease inhibitor ZVAD-fmk, the more selective caspase inhibitor DEVD-CHO and by the viral serpin CrmA.	ammonium ferrous sulfate	5-8	macrophage stimulating 1	Homo sapiens	29-33
9545236-3	1998	CD95/Fas-induced cleavage of Mst1 was blocked by the cysteine protease inhibitor ZVAD-fmk, the more selective caspase inhibitor DEVD-CHO and by the viral serpin CrmA.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	81-89	macrophage stimulating 1	Homo sapiens	29-33
9545236-3	1998	CD95/Fas-induced cleavage of Mst1 was blocked by the cysteine protease inhibitor ZVAD-fmk, the more selective caspase inhibitor DEVD-CHO and by the viral serpin CrmA.	aspartyl-glutamyl-valyl-aspartal	128-136	macrophage stimulating 1	Homo sapiens	29-33
9185522-3	1997	We differentially screened a chromosome 3 library using nitrosamine-treated versus normal hamster lung cDNAs and identified hepatocyte growth factor-like/macrophage-stimulating protein (HGFL/MSP) in injured lung.	Nitrosamines	56-67	macrophage stimulating 1	Homo sapiens	186-190
9185522-7	1997	Nitrosamine-treated hamsters also demonstrate pulmonary neuroendocrine cell apoptosis in situ during the same time period as expression of the endogenous HGFL/ MSP gene, immediately preceding the spontaneous regression of neuroendocrine cell hyperplasia.	Nitrosamines	0-11	macrophage stimulating 1	Homo sapiens	154-158
9185522-7	1997	Nitrosamine-treated hamsters also demonstrate pulmonary neuroendocrine cell apoptosis in situ during the same time period as expression of the endogenous HGFL/ MSP gene, immediately preceding the spontaneous regression of neuroendocrine cell hyperplasia.	Nitrosamines	0-11	macrophage stimulating 1	Homo sapiens	160-163
9533936-0	1998	Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration.	Tyrosine	101-109	macrophage stimulating 1	Homo sapiens	0-30
9533936-1	1998	Previously, we identified macrophage-stimulating protein (MSP) as being expressed during hamster lung injury induced by nitrosamine carcinogens.	Nitrosamines	120-131	macrophage stimulating 1	Homo sapiens	26-56
9533936-1	1998	Previously, we identified macrophage-stimulating protein (MSP) as being expressed during hamster lung injury induced by nitrosamine carcinogens.	Nitrosamines	120-131	macrophage stimulating 1	Homo sapiens	58-61
9533936-7	1998	RON was functional in all tested RON mRNA-positive cell lines, with exogenous MSP inducing RON-mediated tyrosine phosphorylation.	Tyrosine	104-112	macrophage stimulating 1	Homo sapiens	78-81
7508914-3	1994	In this work, we expressed [35S]cysteine-labeled recombinant pro-MSP in MSP cDNA-transfected Chinese hamster ovary cells and studied proteolytic processing of pro-MSP and the requirement of cleavage for biological activity.	Sulfur-35	28-31	macrophage stimulating 1	Homo sapiens	65-68
7756992-3	1994	Models of the N domains of HGF/SF, HGF1/MSP, and plasminogen, characterized by the presence of 4 conserved Cys residues forming a loop in a loop, have been modeled based on disulfide-bond constraints.	Cysteine	107-110	macrophage stimulating 1	Homo sapiens	35-43
8062829-5	1994	In vivo, tyrosine phosphorylation of p185RON is induced by stimulation with macrophage stimulating protein (MSP), a protease-like factor containing four "kringle" domains, homologous to HGF.	Tyrosine	9-17	macrophage stimulating 1	Homo sapiens	76-106
8062829-5	1994	In vivo, tyrosine phosphorylation of p185RON is induced by stimulation with macrophage stimulating protein (MSP), a protease-like factor containing four "kringle" domains, homologous to HGF.	Tyrosine	9-17	macrophage stimulating 1	Homo sapiens	108-111
8062829-6	1994	In epithelial cells, MSP-induced tyrosine phosphorylation of p185RON is followed by DNA synthesis.	Tyrosine	33-41	macrophage stimulating 1	Homo sapiens	21-24
7508914-3	1994	In this work, we expressed [35S]cysteine-labeled recombinant pro-MSP in MSP cDNA-transfected Chinese hamster ovary cells and studied proteolytic processing of pro-MSP and the requirement of cleavage for biological activity.	Cysteine	32-40	macrophage stimulating 1	Homo sapiens	65-68
7508914-3	1994	In this work, we expressed [35S]cysteine-labeled recombinant pro-MSP in MSP cDNA-transfected Chinese hamster ovary cells and studied proteolytic processing of pro-MSP and the requirement of cleavage for biological activity.	Cysteine	32-40	macrophage stimulating 1	Homo sapiens	72-75
7508914-3	1994	In this work, we expressed [35S]cysteine-labeled recombinant pro-MSP in MSP cDNA-transfected Chinese hamster ovary cells and studied proteolytic processing of pro-MSP and the requirement of cleavage for biological activity.	Cysteine	32-40	macrophage stimulating 1	Homo sapiens	72-75
1311637-6	1992	Restriction fragment length polymorphism analysis confirmed this loss by showing that THR-X was reduced to homozygosity for D3S30, a 3p13 probe, but remained heterozygous for the distal 3p21.3 probe, D3F15S2.	Threonine	86-89	macrophage stimulating 1	Homo sapiens	200-207
1550126-4	1992	We have isolated cDNAs homologous to conserved fragments within cA476; and these cDNAs have 96% sequence similarity to a cDNA derived from the DNF15S2 locus.	ca476	64-69	macrophage stimulating 1	Homo sapiens	143-150
1550126-6	1992	Cosmid cA476 (DNF15S2) has been mapped, by fluorescent in situ hybridization, to chromosome 3p21.3.	ca476	7-12	macrophage stimulating 1	Homo sapiens	14-21
7691976-1	1993	Macrophage stimulating protein (MSP) is a member of a family of proteins characterized by a triple disulfide loop structure (kringle).	Disulfides	99-108	macrophage stimulating 1	Homo sapiens	0-30
7691976-1	1993	Macrophage stimulating protein (MSP) is a member of a family of proteins characterized by a triple disulfide loop structure (kringle).	Disulfides	99-108	macrophage stimulating 1	Homo sapiens	32-35
8393443-1	1993	A human hepatoma (HepG2) cell line library was screened with an oligonucleotide probe for macrophage stimulating protein (MSP) to clone an MSP cDNA.	Oligonucleotides	64-79	macrophage stimulating 1	Homo sapiens	90-120
34318610-0	2021	Alkaloid leonurine exerts anti-inflammatory effects via modulating MST1 expression in trophoblast cells.	leonurine	9-18	macrophage stimulating 1	Homo sapiens	67-71
34967918-2	2021	In this study, exposure of mouse primary cortical neurons to NMDA resulted in the cleavage and activation of mammalian sterile 20-like kinase-1 (MST1), both of which were mediated by calpain 1.	N-Methylaspartate	61-65	macrophage stimulating 1	Homo sapiens	109-143
34967918-2	2021	In this study, exposure of mouse primary cortical neurons to NMDA resulted in the cleavage and activation of mammalian sterile 20-like kinase-1 (MST1), both of which were mediated by calpain 1.	N-Methylaspartate	61-65	macrophage stimulating 1	Homo sapiens	145-149
2289299-2	1990	Mefloquine was administered alone (750 mg orally; group 1), or with primaquine (PQ, 45 mg; group 2), or in combination with sulfadoxine (1.5 g) + pyrimethamine (75 mg) (MSP; group 3), or as MSP + PQ (group 4).	Mefloquine	0-10	macrophage stimulating 1	Homo sapiens	169-172
2289299-2	1990	Mefloquine was administered alone (750 mg orally; group 1), or with primaquine (PQ, 45 mg; group 2), or in combination with sulfadoxine (1.5 g) + pyrimethamine (75 mg) (MSP; group 3), or as MSP + PQ (group 4).	Mefloquine	0-10	macrophage stimulating 1	Homo sapiens	190-193
35088536-2	2022	Thus, mammalian Ste20-like kinase 1/2 (MST1/2) as the core serine-threonine kinases in the Hippo signalling pathway has been investigated for its role in immunological disease.	Serine	59-65	macrophage stimulating 1	Homo sapiens	39-45
34395269-6	2021	Its core consists of the serine/threonine kinases mammalian sterile 20-like kinase 1 and 2 (MST1/2) and large tumor suppressor 1 and 2.	Serine	25-31	macrophage stimulating 1	Homo sapiens	92-98
35571412-11	2022	Mechanistically, we determined that cGAS/STING activation leads to increased mitochondrial ROS levels, and thereby increases phosphorylation of mammalian sterile 20-like kinase 1 (MST1), a core component of the Hippo pathway, subsequently promoting activation of forkhead box1 (FOXO1).	Reactive Oxygen Species	91-94	macrophage stimulating 1	Homo sapiens	180-184
35370966-2	2022	Mammalian Sterile 20-like kinase 1 (MST1) is a key mediator of beta-cell failure and the identification of neratinib as MST1 inhibitor with potent effects on beta-cell survival represents a promising approach for causative diabetes therapy.	neratinib	107-116	macrophage stimulating 1	Homo sapiens	120-124
35370966-3	2022	Here we report a case of robust glycemia and HbA1c normalization in a patient with breast cancer-T2D comorbidity under neratinib, a potent triple kinase inhibitor of HER2/EGFR and MST1.	neratinib	119-128	macrophage stimulating 1	Homo sapiens	180-184
35370966-7	2022	This clinical case reports the combination of HER2/EGFR/MST1-inhibition by neratinib for the pharmacological intervention to effectively restore normoglycemia in a patient with poorly controlled T2D and suggests neratinib as potent therapeutic regimen for the cancer-diabetes comorbidity.	neratinib	75-84	macrophage stimulating 1	Homo sapiens	56-60
34678143-4	2021	Accumulated glycogen undergoes liquid-liquid phase separation, which results in the assembly of the Laforin-Mst1/2 complex and consequently sequesters Hippo kinases Mst1/2 in glycogen liquid droplets to relieve their inhibition on Yap.	Glycogen	12-20	macrophage stimulating 1	Homo sapiens	165-171
34678143-4	2021	Accumulated glycogen undergoes liquid-liquid phase separation, which results in the assembly of the Laforin-Mst1/2 complex and consequently sequesters Hippo kinases Mst1/2 in glycogen liquid droplets to relieve their inhibition on Yap.	Glycogen	175-183	macrophage stimulating 1	Homo sapiens	165-171
34126237-6	2021	Luciferase activity assay was used to identify PAHRF/ miR-23a-3p/serine/threonine kinase 4 (STK4/MST1) interaction.	Serine	65-71	macrophage stimulating 1	Homo sapiens	97-101
35385779-3	2022	Here, we showed that Mst1 is up-regulated in Parkinson"s disease (PD) model induced by MPP+.	mangion-purified polysaccharide (Candida albicans)	87-91	macrophage stimulating 1	Homo sapiens	21-25
35385779-4	2022	Knockdown of Mst1 resulted in a reduction in MPP+-induced apoptosis and autophagy in SH-SY5Y and CHP 212 cells.	mangion-purified polysaccharide (Candida albicans)	45-49	macrophage stimulating 1	Homo sapiens	13-17
35385779-6	2022	We also showed that miR-135a-5p was lower while Mst1 was inversely higher in MPP+-treated cells.	mangion-purified polysaccharide (Candida albicans)	77-81	macrophage stimulating 1	Homo sapiens	48-52
35385779-7	2022	Furthermore, miR-135a-5p has a protective role on MPP+-induced neuronal cell death via targeting Mst1.	mir-135a-5p	13-24	macrophage stimulating 1	Homo sapiens	97-101
35385779-7	2022	Furthermore, miR-135a-5p has a protective role on MPP+-induced neuronal cell death via targeting Mst1.	mangion-purified polysaccharide (Candida albicans)	50-54	macrophage stimulating 1	Homo sapiens	97-101
35295173-0	2022	Role of MiR-27a-3p in Intervertebral Disc Degeneration through Targeting RASSF5 via MST1/LATS1 and RAS/RAC1 Signaling Pathway.	mir-27a-3p	8-18	macrophage stimulating 1	Homo sapiens	84-88
35295173-12	2022	Finally, miR-27a-3p could downregulate RASSF5 and affected the MST1/LATS1 and RAS/RAC1 pathway.	mir-27a-3p	9-19	macrophage stimulating 1	Homo sapiens	63-67
35311132-10	2022	Finally, the effects of alpha-hederin on HCC cell proliferation and apoptosis were alleviated by XMU-MP-1, a Mst1/2 inhibitor in vitro.	beta-hederin	24-37	macrophage stimulating 1	Homo sapiens	109-115
2565880-6	1989	Sequence analysis indicated that the DNF15S2 locus could potentially code for a previously unreported protein of 67 kDa which has 26 cysteine residues.	Cysteine	133-141	macrophage stimulating 1	Homo sapiens	37-44
32975614-2	2021	Here we show that mammalian ste20-like kinase 1/serine/threonine kinase 4 (MST1/STK4) functions as a negative regulator of lipopolysaccharide (LPS)-induced activation of the TLR4-NF-kappaB signaling pathway associated with inflammation.	Serine	48-54	macrophage stimulating 1	Homo sapiens	75-79
2858743-1	1985	Two randomised double-blind trials were conducted to examine the activity and tolerability of mefloquine alone and in combination with sulfadoxine/pyrimethamine (MSP).	fanasil, pyrimethamine drug combination	135-160	macrophage stimulating 1	Homo sapiens	162-165
2858743-5	1985	The other trial showed that a single oral dose of 750 mg mefloquine and a single oral dose of MSP (750 mg mefloquine plus 3 tablets of "Fansidar", were equally effective in the treatment of falciparum malaria.	Mefloquine	106-116	macrophage stimulating 1	Homo sapiens	94-97
6158965-2	1980	MSP migrates as a single homogeneous protein on SDS PAGE and comparison of these data and ultracentrifuge analyses indicates that MSP contains a single polypeptide chain.	Sodium Dodecyl Sulfate	48-51	macrophage stimulating 1	Homo sapiens	0-3
32692720-9	2020	This suggests the Mst1-AMPK-Sirt1 axis is a potential target for RA therapy.	Radium	65-67	macrophage stimulating 1	Homo sapiens	18-22
33298178-4	2020	Mammalian Ste20-like kinase 1 (Mst1) is a pro-apoptotic molecule which increases ROS production.	Reactive Oxygen Species	81-84	macrophage stimulating 1	Homo sapiens	31-35
33298178-5	2020	The aim of this study is to uncover the underlying mechanisms the effect of Mst1 inhibition on the tolerance of BM-MSCs under H2O2 condition.	Hydrogen Peroxide	126-130	macrophage stimulating 1	Homo sapiens	76-80
33298178-6	2020	METHODS: Mst1 expression in BM-MSCs was inhibited via transfection with adenoviruses expressing a short hairpin (sh) RNA directed against Mst1 (Ad-sh-Mst1) and exposure to H2O2.	Hydrogen Peroxide	172-176	macrophage stimulating 1	Homo sapiens	9-13
33298178-11	2020	RESULTS: Mst1 inhibition reduced ROS production; increased antioxidant enzyme SOD1/2, CAT, and GPx expression; maintained DeltaPsim; and alleviated cell apoptosis in H2O2-treated BM-MSCs.	Reactive Oxygen Species	33-36	macrophage stimulating 1	Homo sapiens	9-13
33298178-11	2020	RESULTS: Mst1 inhibition reduced ROS production; increased antioxidant enzyme SOD1/2, CAT, and GPx expression; maintained DeltaPsim; and alleviated cell apoptosis in H2O2-treated BM-MSCs.	Hydrogen Peroxide	166-170	macrophage stimulating 1	Homo sapiens	9-13
32741119-1	2020	Mammalian STE20-like kinase 1 (MST1/STK4/KRS2) encodes a serine-threonine kinase that is the mammalian homolog of Drosophila Hippo.	Serine	57-63	macrophage stimulating 1	Homo sapiens	31-35
32627655-4	2020	LncRNA SNHG17 and Mammalian Sterile 20-like kinase 1 (Mst1) expression were upregulated in glomeruli and podocytes of DM mice and high glucose-treated podocytes, whereas Parkin expression was downregulated.	Glucose	135-142	macrophage stimulating 1	Homo sapiens	54-58
33442415-6	2021	Additionally, CyH significantly down-regulated YAP and TAZ expression and up-regulated LAST1/2 and MST1/2 expression, and CyH inhibited the interaction between YAP and TEAD.	cytochalasin H	14-17	macrophage stimulating 1	Homo sapiens	99-105
33298178-15	2020	CONCLUSION: Mst1 inhibition mediated the cytoprotective action of mBM-MSCs against H2O2-induced oxidative stress injury.	Hydrogen Peroxide	83-87	macrophage stimulating 1	Homo sapiens	12-16
32335916-8	2020	Then, the active Mst1-JNK pathway mediated mitochondrial reactive oxygen species (mROS) overproduction and then excessive ROS induced cancer cell death.	Reactive Oxygen Species	57-80	macrophage stimulating 1	Homo sapiens	17-21
32335916-8	2020	Then, the active Mst1-JNK pathway mediated mitochondrial reactive oxygen species (mROS) overproduction and then excessive ROS induced cancer cell death.	Reactive Oxygen Species	83-86	macrophage stimulating 1	Homo sapiens	17-21
33109096-11	2020	Furthermore, when circCRAMP1L was utilised in combination with its target protein macrophage stimulating protein (MSP), the predictive performance increased, with an area under the receiver operating characteristic curve of 0.928 (95% CI 0.882-0.974), 80.0% sensitivity, and 80.0% specificity.	circcramp1l	18-29	macrophage stimulating 1	Homo sapiens	82-112
33109096-11	2020	Furthermore, when circCRAMP1L was utilised in combination with its target protein macrophage stimulating protein (MSP), the predictive performance increased, with an area under the receiver operating characteristic curve of 0.928 (95% CI 0.882-0.974), 80.0% sensitivity, and 80.0% specificity.	circcramp1l	18-29	macrophage stimulating 1	Homo sapiens	114-117
32929029-4	2020	Here, we demonstrate that Netrin1 reduction in Parkinson"s disease (PD) activates MST1, which selectively binds and phosphorylates netrin receptor UNC5B on T428 residue, promoting its apoptotic activation and dopaminergic neuronal loss.	t428	156-160	macrophage stimulating 1	Homo sapiens	82-86
32692720-2	2020	Mst1 mRNA and protein expression was significantly higher in hydrogen peroxide (H2O2)-treated RA-FLSs than untreated controls.	Hydrogen Peroxide	61-78	macrophage stimulating 1	Homo sapiens	0-4
32692720-2	2020	Mst1 mRNA and protein expression was significantly higher in hydrogen peroxide (H2O2)-treated RA-FLSs than untreated controls.	Hydrogen Peroxide	80-84	macrophage stimulating 1	Homo sapiens	0-4
32692720-6	2020	Sirt1 expression was significantly reduced in the H2O2-treated RA-FLSs, but was higher in the H2O2-treated Mst1-silenced RA-FLSs.	Hydrogen Peroxide	94-98	macrophage stimulating 1	Homo sapiens	107-111
32692720-7	2020	Pretreatment with selisistat (Sirt1-specific inhibitor) or compound C (AMPK antagonist) significantly reduced the viability and mitochondrial function in H2O2-treated Mst1-silenced RA-FLSs by inhibiting Sirt1 function or Sirt1 expression, respectively.	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	18-28	macrophage stimulating 1	Homo sapiens	167-171
32692720-7	2020	Pretreatment with selisistat (Sirt1-specific inhibitor) or compound C (AMPK antagonist) significantly reduced the viability and mitochondrial function in H2O2-treated Mst1-silenced RA-FLSs by inhibiting Sirt1 function or Sirt1 expression, respectively.	Hydrogen Peroxide	154-158	macrophage stimulating 1	Homo sapiens	167-171
32468668-1	2020	The activated mammalian ste20-like serine/threonine kinases 1 (MST1) was found in the central nervous system diseases, such as cerebral ischemia, stroke and ALS, which were related with cognitions.	Serine	35-41	macrophage stimulating 1	Homo sapiens	63-67
32376689-6	2020	We also found that androgen exposure antagonizes Ser/Thr kinase 4 (STK4/MST1) signaling, stimulates the activity of protein phosphatase 2A, and thereby attenuates the phospho-Ser-127 modification and promotes YAP1 nuclear localization.	Serine	49-52	macrophage stimulating 1	Homo sapiens	72-76
32377725-3	2020	Moreover, MST1 overexpression in PANC-1 cells led to increased apoptosis as determined by MTT and TUNEL assays and inhibited cellular migration.	monooxyethylene trimethylolpropane tristearate	90-93	macrophage stimulating 1	Homo sapiens	10-14
32377725-4	2020	Mechanistically, upregulation of MST1 expression caused mitochondrial dysfunction, decreased ATP production, and activation of the mitochondrial-dependent apoptotic pathway via inhibition of mitofusin 2 (Mfn2)-mediated mitophagy, which ultimately resulted in increased cellular apoptosis and decreased cellular migration.	Adenosine Triphosphate	93-96	macrophage stimulating 1	Homo sapiens	33-37
32439835-5	2020	Here we found that the small molecule lycorine notably increased SAV1 levels in lung cancer cells by inhibiting SAV1 degradation via a ubiquitin-lysosome system, and inducing phosphorylation and activation of the SAV1-interacting protein mammalian Ste20-like 1 (MST1).	lycorine	38-46	macrophage stimulating 1	Homo sapiens	262-266
31815004-0	2019	Neratinib is an MST1 inhibitor and restores pancreatic beta-cells in diabetes.	neratinib	0-9	macrophage stimulating 1	Homo sapiens	16-20
32435241-1	2020	The STE20-like serine/threonine kinases MST1 and MST2 (MST1/2) are mammalian homologs of Hippo in flies.	Serine	15-21	macrophage stimulating 1	Homo sapiens	40-44
31119640-9	2020	Finally, expression levels of Hippo pathway kinases Lats2, MST1, and scaffold protein Sav1 were reduced in these cells, suggesting a possible link between Hippo pathway-dependent downregulation of PPARgamma and the NaB/F68 treatment.	nab	215-218	macrophage stimulating 1	Homo sapiens	59-63
30903103-4	2019	In COS-1 cells, MST1 was phosphorylated at Y433 residue in an FGFR4 kinase activity-dependent manner, as assessed by mass spectrometry.	y433	43-47	macrophage stimulating 1	Homo sapiens	16-20
30903103-5	2019	Blockade of this phosphorylation by Y433F mutation induced MST1 activation, as indicated by increased threonine phosphorylation of MST1/2, and the downstream substrate MOB1, in FGFR4-overexpressing T47D and MDA-MB-231 breast cancer cells.	Threonine	102-111	macrophage stimulating 1	Homo sapiens	59-63
30903103-5	2019	Blockade of this phosphorylation by Y433F mutation induced MST1 activation, as indicated by increased threonine phosphorylation of MST1/2, and the downstream substrate MOB1, in FGFR4-overexpressing T47D and MDA-MB-231 breast cancer cells.	Threonine	102-111	macrophage stimulating 1	Homo sapiens	131-137
31547587-8	2019	Gene ontology analysis revealed that several genes, such as the Hippo pathway upstream target gene, ras association domain family (RASSF1), and its downstream target genes (MST1, MST2, and LATS1) were significantly upregulated by UA, while the expression of YAP1 gene, together with oncogenes (FOXM1, KRAS, and BATF), were significantly decreased.	ursolic acid	230-232	macrophage stimulating 1	Homo sapiens	173-177
31169304-0	2019	Melatonin attenuates inflammation-related venous endothelial cells apoptosis through modulating the MST1-MIEF1 pathway.	Melatonin	0-9	macrophage stimulating 1	Homo sapiens	100-104
31169304-7	2019	Interestingly, melatonin effectively suppressed MST1-MIEF1 axis and thus improved cell survival ratio under TNF-alpha-mediated inflammation injury.	Melatonin	15-24	macrophage stimulating 1	Homo sapiens	48-52
31169304-8	2019	Reactivation of MST1-MIEF1 pathway attenuated melatonin-related endothelial protective actions.	Melatonin	46-55	macrophage stimulating 1	Homo sapiens	16-20
31169304-9	2019	Herein, our results illuminate that melatonin is an effective approach to attenuate inflammation-related venous endothelial cell damage through handling the MST1-MIEF1 signaling pathway.	Melatonin	36-45	macrophage stimulating 1	Homo sapiens	157-161
31256303-0	2019	Inhibitory effect of melatonin on Mst1 ameliorates myocarditis through attenuating ER stress and mitochondrial dysfunction.	Melatonin	21-30	macrophage stimulating 1	Homo sapiens	34-38
31256303-12	2019	To the end, we found that Mst1 was upregulated by virus infection; this effect was attenuated through supplementation with melatonin.	Melatonin	123-132	macrophage stimulating 1	Homo sapiens	26-30
31256303-13	2019	However, Mst1 overexpression reduced the beneficial impact exerted by melatonin on cardiomyocyte viability, mitochondrial function and ER homeostasis.	Melatonin	70-79	macrophage stimulating 1	Homo sapiens	9-13
31256303-14	2019	Our study illustrated that melatonin treatment attenuated viral myocarditis via sustaining cardiomyocyte viability, repressing mitochondrial dysfunction and inhibiting ER stress in a manner dependent on Mst1 inhibition.	Melatonin	27-36	macrophage stimulating 1	Homo sapiens	203-207
31547587-9	2019	Similar to the gene expression profiling results, the protein levels of RASSF1, MST1, MST2, LATS1, and p-YAP were increased, whereas those of CTGF were decreased by UA in gastric cancer cells.	ursolic acid	165-167	macrophage stimulating 1	Homo sapiens	80-84
31792377-5	2019	Following serum or lysophosphatidic acid stimulation, active RhoA binds and dissociates rhophilin and NF2/Kibra from STRIPAK, thereby inducing the association and dephosphorylation of MST1/2 and MAP4Ks by the STRIPAK phosphatase catalytic subunit PP2AC.	lysophosphatidic acid	19-40	macrophage stimulating 1	Homo sapiens	184-190
31676778-4	2019	Here, we identify neratinib, an FDA-approved drug targeting HER2/EGFR dual kinases, as a potent MST1 inhibitor, which improves beta-cell survival under multiple diabetogenic conditions in human islets and INS-1E cells.	neratinib	18-27	macrophage stimulating 1	Homo sapiens	96-100
31676778-6	2019	In summary, neratinib is a previously unrecognized inhibitor of MST1 and represents a potential beta-cell-protective drug with proof-of-concept in vitro in human islets and in vivo in rodent models of both type 1 and type 2 diabetes.	neratinib	12-21	macrophage stimulating 1	Homo sapiens	64-68
29674007-5	2019	Enhanced mitophagy was observed in Mst1 interfering cardiomyocytes subjected to high glucose treatment using 3-Methyladenine and Chloroquine.	Glucose	85-92	macrophage stimulating 1	Homo sapiens	35-39
31572367-1	2019	Mst1 is a multifunctional serine/threonine kinase that is highly expressed in several immune organs.	cholecystokinin C-terminal flanking peptide	26-32	macrophage stimulating 1	Homo sapiens	0-4
31572367-1	2019	Mst1 is a multifunctional serine/threonine kinase that is highly expressed in several immune organs.	glycyl-threonine	33-42	macrophage stimulating 1	Homo sapiens	0-4
30891776-11	2019	When Mst1 was overexpressed or phosphoinositide 3-kinases suppressed, the effects of scutellarin were significantly blocked.	scutellarin	85-96	macrophage stimulating 1	Homo sapiens	5-9
31803403-3	2019	These three proteases have two substrates in common, hepatocyte growth factor (HGF) and macrophage stimulating protein (MSP), the ligands for MET and recepteur d"origine nantais (RON) receptor tyrosine kinases.	Tyrosine	193-201	macrophage stimulating 1	Homo sapiens	88-118
31803403-3	2019	These three proteases have two substrates in common, hepatocyte growth factor (HGF) and macrophage stimulating protein (MSP), the ligands for MET and recepteur d"origine nantais (RON) receptor tyrosine kinases.	Tyrosine	193-201	macrophage stimulating 1	Homo sapiens	120-123
31803403-4	2019	Mechanism-based tetrapeptide and benzamidine inhibitors of these proteases have been shown to block HGF/MET and MSP/RON cancer cell signaling.	tetrapeptide B	16-28	macrophage stimulating 1	Homo sapiens	112-115
31803403-4	2019	Mechanism-based tetrapeptide and benzamidine inhibitors of these proteases have been shown to block HGF/MET and MSP/RON cancer cell signaling.	benzamidine	33-44	macrophage stimulating 1	Homo sapiens	112-115
29674007-5	2019	Enhanced mitophagy was observed in Mst1 interfering cardiomyocytes subjected to high glucose treatment using 3-Methyladenine and Chloroquine.	3-methyladenine	109-124	macrophage stimulating 1	Homo sapiens	35-39
29674007-5	2019	Enhanced mitophagy was observed in Mst1 interfering cardiomyocytes subjected to high glucose treatment using 3-Methyladenine and Chloroquine.	Chloroquine	129-140	macrophage stimulating 1	Homo sapiens	35-39
30256412-6	2019	Importantly, overexpression of HSPB1 promoted the complex formation between HSPB1 and oxidized Prx1, leading to dephosphorylation of STE-mammalian STE20-like kinase 1 (MST1) in H9c2 cells exposed to H2 O 2 , whereas downregulation of HSPB1 induced the opposite results.	Hydrogen Peroxide	199-205	macrophage stimulating 1	Homo sapiens	168-172
30796177-0	2019	MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis.	Reactive Oxygen Species	50-53	macrophage stimulating 1	Homo sapiens	0-4
30796177-5	2019	Further studies demonstrated that pyroptosis induced by MST1 was independent of the Hippo pathway, but mediated by reactive oxygen species (ROS).	Reactive Oxygen Species	115-138	macrophage stimulating 1	Homo sapiens	56-60
30796177-5	2019	Further studies demonstrated that pyroptosis induced by MST1 was independent of the Hippo pathway, but mediated by reactive oxygen species (ROS).	Reactive Oxygen Species	140-143	macrophage stimulating 1	Homo sapiens	56-60
30796177-6	2019	And ROS scavenger N-acetyl-cysteine attenuated the activation of caspase-1 induced by MST1 and the effect of MST1 in PDAC cell death, proliferation, migration, and invasion.	Reactive Oxygen Species	4-7	macrophage stimulating 1	Homo sapiens	86-90
30796177-6	2019	And ROS scavenger N-acetyl-cysteine attenuated the activation of caspase-1 induced by MST1 and the effect of MST1 in PDAC cell death, proliferation, migration, and invasion.	Acetylcysteine	18-35	macrophage stimulating 1	Homo sapiens	86-90
30796177-6	2019	And ROS scavenger N-acetyl-cysteine attenuated the activation of caspase-1 induced by MST1 and the effect of MST1 in PDAC cell death, proliferation, migration, and invasion.	Acetylcysteine	18-35	macrophage stimulating 1	Homo sapiens	109-113
30796177-7	2019	Collectively, our study demonstrated that MST1 suppressed the progression of PDAC cells at least partly through ROS-induced pyroptosis.	Reactive Oxygen Species	112-115	macrophage stimulating 1	Homo sapiens	42-46
30626284-2	2019	Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at threonine 108 (T108) within its BH3 domain blocks macroautophagy/autophagy by increasing BECN1 affinity for its negative regulators, the anti-apoptotic proteins BCL2/Bcl-2 and BCL2L1/Bcl-xL.	Threonine	72-81	macrophage stimulating 1	Homo sapiens	64-68
30155612-10	2019	Further, we demonstrated that the Mst1-JNK signalling axis was required for matrine-modulated mitochondrial fission.	matrine	76-83	macrophage stimulating 1	Homo sapiens	34-38
30576232-3	2019	This study was therefore conducted to investigate the effects of microRNA-135b (miR-135b) on cisplatin [ cis-diamminedichloroplatinum (CDDP)] resistance of GC cells through the MAPK signaling pathway by targeting mammalian ste20-like kinase 1 (MST1).	Cisplatin	93-102	macrophage stimulating 1	Homo sapiens	244-248
30155612-13	2019	By contrast, matrine exerted an anticancer function in liver cancer by activating mitochondrial fission mediated by Mst1-JNK pathways.	matrine	13-20	macrophage stimulating 1	Homo sapiens	116-120
30795621-0	2019	The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells.	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	91-99	macrophage stimulating 1	Homo sapiens	12-16
30795621-5	2019	Here, we show the rapid activation of the MEK-ERK-MST1 axis together with the cleavage and activation of caspase-3, -6, -7, -8, and -9 after PI3K signaling blockade by the selective inhibitor GDC-0941 in Jurkat T cells.	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	192-200	macrophage stimulating 1	Homo sapiens	50-54
30795621-6	2019	We determined the phosphorylation pattern of MST1 using a phosphoproteomic approach and identified two amino acid residues phosphorylated in an ERK-dependent manner after GDC-0941 treatment together with a novel phosphorylation site at S21 residue, which was extensively phosphorylated in an ERK-independent manner during PI3K signaling blockade.	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	171-179	macrophage stimulating 1	Homo sapiens	45-49
30338935-0	2019	Cardiac-specific Mst1 deficiency inhibits ROS-mediated JNK signalling to alleviate Ang II-induced cardiomyocyte apoptosis.	Reactive Oxygen Species	42-45	macrophage stimulating 1	Homo sapiens	17-21
31699221-5	2019	Regarding the Hippo signaling in innate immunity, we have reported that Mst1/2 kinases are required for phagocytosis and efficient clearance of bacteria in phagocytes by regulating reactive oxygen species (ROS) production; and at the same time, by sensing the excessive ROS, Mst1/2 kinases maintain cellular redox homeostasis and prevent phagocytes aging and death through modulating the stability of the key antioxidant transcription factor Nrf2.	Oxygen	190-196	macrophage stimulating 1	Homo sapiens	72-78
30745141-5	2019	The activated Mst1/2 subsequently phosphorylates and stabilizes SHP to downregulate the key bile acid-synthesis enzyme Cyp7a1 expression, thereby limiting bile acid synthesis.	Bile Acids and Salts	92-101	macrophage stimulating 1	Homo sapiens	14-20
30745141-5	2019	The activated Mst1/2 subsequently phosphorylates and stabilizes SHP to downregulate the key bile acid-synthesis enzyme Cyp7a1 expression, thereby limiting bile acid synthesis.	Bile Acids and Salts	155-164	macrophage stimulating 1	Homo sapiens	14-20
30765703-3	2019	Here we show that the kinases Mst1 and Mst2 (Mst1/2) sense ROS and maintain cellular redox balance by modulating the stability of antioxidant transcription factor Nrf2.	Reactive Oxygen Species	59-62	macrophage stimulating 1	Homo sapiens	30-34
30632064-9	2019	Mechanistically, melatonin sustained MFN2-related mitochondrial fusion via suppressing Mst1-Hippo pathway.	Melatonin	17-26	macrophage stimulating 1	Homo sapiens	87-91
30632064-10	2019	Overexpression of Mst1 attenuated the beneficial effects of melatonin on mitochondrial fusion, evoking mitochondrial damage and neuron death in the setting of brain reperfusion stress.	Melatonin	60-69	macrophage stimulating 1	Homo sapiens	18-22
30632064-12	2019	Melatonin treatment activated MFN2-related mitochondrial fusion via suppressing Mst1-Hippo pathway, finally sustaining mitochondrial function and reducing reperfusion-mediated cerebral injury.	Melatonin	0-9	macrophage stimulating 1	Homo sapiens	80-84
30338935-5	2019	In vitro and in vivo experiments showed that Ang II increased intracellular reactive oxygen species (ROS) production and cardiomyocyte apoptosis; these were reversed by administration of the ROS scavenger N-acetylcysteine and by Mst1 deficiency, which suppressed c-Jun N-terminal kinase (JNK) phosphorylation and downstream signaling.	Reactive Oxygen Species	191-194	macrophage stimulating 1	Homo sapiens	229-233
30338935-7	2019	Thus, cardiac-specific Mst1 knockout inhibits ROS-mediated JNK signalling to block Ang II-induced cardiomyocyte apoptosis, suggesting Mst1 as a potential therapeutic target for treatment of RAAS-activated heart failure.	Reactive Oxygen Species	46-49	macrophage stimulating 1	Homo sapiens	23-27
30565142-3	2019	Here, we describe in detail the protocol for an in-gel kinase assay for the quantification of the kinase activity of MST1/2, which involves immunoprecipitation of MST1/2 and the incorporation of radiolabeled phosphate from [gamma-32P]-ATP into a substrate immobilized in a polyacrylamide gel.	Phosphates	208-217	macrophage stimulating 1	Homo sapiens	117-123
29961191-7	2019	At the molecular level, upregulation of Mst1 promoted ROS production, reduced mitochondrial membrane potential, facilitated the leakage of mitochondrial pro-apoptotic factors into the nucleus, and activated the caspase-9-related apoptotic pathway in reperfused cardiomyocytes.	ros	54-57	macrophage stimulating 1	Homo sapiens	40-44
30565142-3	2019	Here, we describe in detail the protocol for an in-gel kinase assay for the quantification of the kinase activity of MST1/2, which involves immunoprecipitation of MST1/2 and the incorporation of radiolabeled phosphate from [gamma-32P]-ATP into a substrate immobilized in a polyacrylamide gel.	[gamma-32P]-ATP	223-238	macrophage stimulating 1	Homo sapiens	117-123
30565142-3	2019	Here, we describe in detail the protocol for an in-gel kinase assay for the quantification of the kinase activity of MST1/2, which involves immunoprecipitation of MST1/2 and the incorporation of radiolabeled phosphate from [gamma-32P]-ATP into a substrate immobilized in a polyacrylamide gel.	polyacrylamide	273-287	macrophage stimulating 1	Homo sapiens	117-123
30366669-5	2018	We also observed that DHA-induced YAP phosphorylation was reversed by both the LATS1 and MST1 siRNAs.	Docosahexaenoic Acids	22-25	macrophage stimulating 1	Homo sapiens	89-93
30035680-0	2018	Roles of the MST1-JNK signaling pathway in apoptosis of colorectal cancer cells induced by Taurine.	Taurine	91-98	macrophage stimulating 1	Homo sapiens	13-17
30035680-1	2018	The aim of this study was to observe the impact of the mammalian sterile 20-like kinase 1-c-Jun N-terminal kinase (MST1-JNK) signaling pathway on apoptosis in colorectal cancer (CRC) cells induced by Taurine (Tau).	Taurine	200-207	macrophage stimulating 1	Homo sapiens	115-119
30384260-4	2019	At the molecular level, Mst1 upregulation exacerbated mitochondrial damage, as evidenced by reduced mitochondrial potential, increased ROS generation, more cyt-c liberation from mitochondria into the cytoplasm, and an activated mitochondrial apoptotic pathway.	ros	135-138	macrophage stimulating 1	Homo sapiens	24-28
30320378-7	2018	At the molecular level, the reintroduction of Mst1 in A549 cells led to activation of mitochondrial apoptosis, as evidenced by a reduction in mitochondrial potential, overproduction of ROS, cytochrome c release from the mitochondria into the nucleus, and upregulation of pro-apoptotic protein expression.	ros	185-188	macrophage stimulating 1	Homo sapiens	46-50
30555239-9	2018	Molecular experiments showed that Mst1 overexpression mediated mitochondrial damage, as evidenced by decreased ATP production, increased ROS generation, more cyt-c translocation from the mitochondria into the cytoplasm and nucleus, and activated the caspase-9-related apoptotic pathway.	Adenosine Triphosphate	111-114	macrophage stimulating 1	Homo sapiens	34-38
30555239-9	2018	Molecular experiments showed that Mst1 overexpression mediated mitochondrial damage, as evidenced by decreased ATP production, increased ROS generation, more cyt-c translocation from the mitochondria into the cytoplasm and nucleus, and activated the caspase-9-related apoptotic pathway.	ros	137-140	macrophage stimulating 1	Homo sapiens	34-38
30063115-9	2018	Furthermore, melatonin inhibited Mammalian sterile 20-like kinase 1 (Mst1) phosphorylation, thus enhancing Parkin-mediated mitophagy, which contributed to mitochondrial quality control.	Melatonin	13-22	macrophage stimulating 1	Homo sapiens	69-73
30453531-7	2018	Nevertheless, RA-V strongly blocks liver enlargement induced by Mst1/2 knockout.	RA V	14-18	macrophage stimulating 1	Homo sapiens	64-70
29903769-2	2018	YAP is known to be regulated by a serine/threonine kinase relay module (MST1/2-LATS1/2) culminating in phosphorylation of YAP at Serine 127 and cytoplasmic sequestration.	Serine	129-135	macrophage stimulating 1	Homo sapiens	72-76
30167083-7	2018	5-azacytidine treatment in sarcoma cell lines modestly reversed expression of predominantly MST1 (8%) and MST2 (17%), indicating CpG island hypermethylation can silence expression of MST1 and MST2.	Azacitidine	0-13	macrophage stimulating 1	Homo sapiens	92-96
30167083-7	2018	5-azacytidine treatment in sarcoma cell lines modestly reversed expression of predominantly MST1 (8%) and MST2 (17%), indicating CpG island hypermethylation can silence expression of MST1 and MST2.	Azacitidine	0-13	macrophage stimulating 1	Homo sapiens	183-187
30167083-8	2018	Trichostatin A treatment reversed expression of MST1 (58%) and MST2 (67%), indicating histone deacetylation also plays a role in silencing expression of MST1 and MST2.	trichostatin A	0-14	macrophage stimulating 1	Homo sapiens	48-52
30167083-8	2018	Trichostatin A treatment reversed expression of MST1 (58%) and MST2 (67%), indicating histone deacetylation also plays a role in silencing expression of MST1 and MST2.	trichostatin A	0-14	macrophage stimulating 1	Homo sapiens	153-157
29732147-0	2018	Adenosine decreases oxidative stress and protects H2O2-treated neural stem cells against apoptosis through decreasing Mst1 expression.	Adenosine	0-9	macrophage stimulating 1	Homo sapiens	118-122
29626488-0	2018	Berberine induced modulation of PHLPP2-Akt-MST1 kinase signaling is coupled with mitochondrial impairment and hepatoma cell death.	Berberine	0-9	macrophage stimulating 1	Homo sapiens	43-47
29626488-4	2018	Present study decoded the crucial role of PHLPP2 in inducing apoptosis by its interaction with the newly found binding partner Mammalian sterile 20-like kinase 1 (Mst1) in berberine (BBR)-treated human hepatoma cells.	Berberine	172-181	macrophage stimulating 1	Homo sapiens	163-167
29626488-4	2018	Present study decoded the crucial role of PHLPP2 in inducing apoptosis by its interaction with the newly found binding partner Mammalian sterile 20-like kinase 1 (Mst1) in berberine (BBR)-treated human hepatoma cells.	Berberine	183-186	macrophage stimulating 1	Homo sapiens	163-167
29626488-9	2018	Consequently, coordination between PHLPP2, Akt and Mst1 stimulated downstream targets c-jun N-terminal kinase (JNK), Bim and Bak which are direct activators of pro-apoptotic proteins leading to cell death.	bakuchiol	125-128	macrophage stimulating 1	Homo sapiens	51-55
29626488-10	2018	Further, PHLPP2/Mst1 knock-down efficiently curtailed anti-proliferative effect of berberine by restoring the basal level of downstream anti-apoptotic proteins.	Berberine	83-92	macrophage stimulating 1	Homo sapiens	16-20
29626488-12	2018	Thus, our findings suggest that PHLPP2, Akt and Mst1 constitute an autoinhibitory triangle which may be partly responsible for antiproliferative effect of berberine.	Berberine	155-164	macrophage stimulating 1	Homo sapiens	48-52
29732147-0	2018	Adenosine decreases oxidative stress and protects H2O2-treated neural stem cells against apoptosis through decreasing Mst1 expression.	Hydrogen Peroxide	50-54	macrophage stimulating 1	Homo sapiens	118-122
29732147-7	2018	Subsequent assays using this dosage indicated that apoptosis rate and Mst1 expression in B-dNSCs pretreated with 6 microM adenosine were significantly decreased compared with the control group.	Adenosine	122-131	macrophage stimulating 1	Homo sapiens	70-74
29632474-6	2018	Furthermore, melatonin inhibited the cleavage of mammalian sterile 20-like kinase 1 (MST1) protein by reducing reactive oxygen species (ROS) content.	Melatonin	13-22	macrophage stimulating 1	Homo sapiens	85-89
31938375-1	2018	Mammalian ste20-like kinase 1 (MST1) is a Ser/Thr kinase involved in cell proliferation, apoptosis, and embryonic development.	seryl-seryl-seryl-arginine	42-45	macrophage stimulating 1	Homo sapiens	31-35
31938375-1	2018	Mammalian ste20-like kinase 1 (MST1) is a Ser/Thr kinase involved in cell proliferation, apoptosis, and embryonic development.	peptide T amide	46-49	macrophage stimulating 1	Homo sapiens	31-35
29686775-6	2018	Results indicated that 10 muM cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells.	luteolin-7-glucoside	30-40	macrophage stimulating 1	Homo sapiens	177-182
29389804-0	2018	Norleual, a hepatocyte growth factor and macrophage stimulating protein dual antagonist, increases pancreatic cancer sensitivity to gemcitabine.	gemcitabine	132-143	macrophage stimulating 1	Homo sapiens	41-71
29686775-6	2018	Results indicated that 10 muM cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells.	Cisplatin	133-142	macrophage stimulating 1	Homo sapiens	177-182
29686775-6	2018	Results indicated that 10 muM cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells.	luteolin-7-glucoside	217-227	macrophage stimulating 1	Homo sapiens	177-182
29632474-6	2018	Furthermore, melatonin inhibited the cleavage of mammalian sterile 20-like kinase 1 (MST1) protein by reducing reactive oxygen species (ROS) content.	Reactive Oxygen Species	111-134	macrophage stimulating 1	Homo sapiens	85-89
29632474-6	2018	Furthermore, melatonin inhibited the cleavage of mammalian sterile 20-like kinase 1 (MST1) protein by reducing reactive oxygen species (ROS) content.	Reactive Oxygen Species	136-139	macrophage stimulating 1	Homo sapiens	85-89
29632474-7	2018	These effects of melatonin on regulating the homeostasis between apoptosis and autophagy could be reversed by an MST1 agonist, chelerythrine, via enhancement of MST1 cleavage.	Melatonin	17-26	macrophage stimulating 1	Homo sapiens	113-117
29632474-7	2018	These effects of melatonin on regulating the homeostasis between apoptosis and autophagy could be reversed by an MST1 agonist, chelerythrine, via enhancement of MST1 cleavage.	Melatonin	17-26	macrophage stimulating 1	Homo sapiens	161-165
29632474-7	2018	These effects of melatonin on regulating the homeostasis between apoptosis and autophagy could be reversed by an MST1 agonist, chelerythrine, via enhancement of MST1 cleavage.	chelerythrine	127-140	macrophage stimulating 1	Homo sapiens	113-117
29632474-7	2018	These effects of melatonin on regulating the homeostasis between apoptosis and autophagy could be reversed by an MST1 agonist, chelerythrine, via enhancement of MST1 cleavage.	chelerythrine	127-140	macrophage stimulating 1	Homo sapiens	161-165
29632474-9	2018	The underlying mechanism may, at least in part, involve the ROS-MST1 pathway.	Reactive Oxygen Species	60-63	macrophage stimulating 1	Homo sapiens	64-68
30537740-8	2018	In vitro, Mst1 upregulation induced mitochondrial damage including mitochondrial potential reduction, ROS overloading, cyt-c liberation and caspase-9 apoptotic pathway activation.	ros	102-105	macrophage stimulating 1	Homo sapiens	10-14
29259009-7	2018	By activating MST1 and the JNK/c-Jun pathway, RASSF4 sensitized MM cells to bortezomib.	Bortezomib	76-86	macrophage stimulating 1	Homo sapiens	14-18
29127009-0	2018	Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.	Nicorandil	0-10	macrophage stimulating 1	Homo sapiens	93-97
29127009-7	2018	Interestingly, nicorandil increased Mst1 and p-Mst1 levels in cardiomyocytes subjected to MI injury.	Nicorandil	15-25	macrophage stimulating 1	Homo sapiens	36-40
29127009-7	2018	Interestingly, nicorandil increased Mst1 and p-Mst1 levels in cardiomyocytes subjected to MI injury.	Nicorandil	15-25	macrophage stimulating 1	Homo sapiens	47-51
29127009-8	2018	Mst1 knockout abolished the protective effects of nicorandil on cardiac remodeling and dysfunction after MI.	Nicorandil	50-60	macrophage stimulating 1	Homo sapiens	0-4
29127009-9	2018	Mst1 knockout also abolished the beneficial effects of nicorandil on cardiac enzyme release and cardiomyocyte autophagy and apoptosis.	Nicorandil	55-65	macrophage stimulating 1	Homo sapiens	0-4
28802229-5	2017	Treatment of glioma cells with the DNA methylation inhibitor 5-aza-2"-deoxycytidine (5-AzadC) prevented the loss of MST1 expression.	Decitabine	61-83	macrophage stimulating 1	Homo sapiens	116-120
29448246-13	2018	Moreover, Mst1-induced defective mitophagy evoked cellular oxidative stress, energy metabolism and calcium overload.	Calcium	99-106	macrophage stimulating 1	Homo sapiens	10-14
28802229-5	2017	Treatment of glioma cells with the DNA methylation inhibitor 5-aza-2"-deoxycytidine (5-AzadC) prevented the loss of MST1 expression.	Decitabine	85-92	macrophage stimulating 1	Homo sapiens	116-120
28366538-3	2017	In this study, we hypothesize that morin, a bioflavonoid, mediates its anti-cancer effect through the activation of Mst1/hippo signaling in liver cancer cells.	morin	35-40	macrophage stimulating 1	Homo sapiens	116-120
28161886-2	2017	Narnatumab (IMC-RON8; LY3012219) is a neutralizing monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP).	ly3012219	22-31	macrophage stimulating 1	Homo sapiens	110-140
28161886-2	2017	Narnatumab (IMC-RON8; LY3012219) is a neutralizing monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP).	ly3012219	22-31	macrophage stimulating 1	Homo sapiens	142-145
28757478-6	2017	More recent studies have revealed that MST1/2 mediates the innate immune response against pathogens or viruses, especially on macrophage phagocytosis as well as cytokines and ROS production.	ros	175-178	macrophage stimulating 1	Homo sapiens	39-45
28698384-5	2017	PA inhibited endothelial cell proliferation, migration, and tube formation, which were associated with increased expression of mammalian Ste20-like kinases 1 (MST1), YAP phosphorylation/inactivation, and nuclear exclusion.	Palmitic Acid	0-2	macrophage stimulating 1	Homo sapiens	159-163
28698384-6	2017	Overexpression of YAP or knockdown of MST1 prevented PA-induced inhibition of angiogenesis.	Palmitic Acid	53-55	macrophage stimulating 1	Homo sapiens	38-42
29088725-0	2017	Hydrogen sulfide ameliorates subarachnoid hemorrhage-induced neuronal apoptosis via the ROS-MST1 pathway.	Hydrogen Sulfide	0-16	macrophage stimulating 1	Homo sapiens	92-96
29088725-0	2017	Hydrogen sulfide ameliorates subarachnoid hemorrhage-induced neuronal apoptosis via the ROS-MST1 pathway.	ros	88-91	macrophage stimulating 1	Homo sapiens	92-96
29088725-7	2017	The underlying mechanisms of H2S in ameliorating neuronal apoptosis might be executed through inhibition of the activity of mammalian sterile 20-like kinase 1 (MST1) protein.	Hydrogen Sulfide	29-32	macrophage stimulating 1	Homo sapiens	160-164
29088725-8	2017	Western blot analysis demonstrated that exogenous NaHS decreased cleaved MST1 (cl-MST1) while increasing full-length MST1 expression.	sodium bisulfide	50-54	macrophage stimulating 1	Homo sapiens	73-77
29088725-8	2017	Western blot analysis demonstrated that exogenous NaHS decreased cleaved MST1 (cl-MST1) while increasing full-length MST1 expression.	sodium bisulfide	50-54	macrophage stimulating 1	Homo sapiens	82-86
29088725-8	2017	Western blot analysis demonstrated that exogenous NaHS decreased cleaved MST1 (cl-MST1) while increasing full-length MST1 expression.	sodium bisulfide	50-54	macrophage stimulating 1	Homo sapiens	82-86
29088725-9	2017	This anti-apoptotic effect of H2S could be reversed by chelerythrine, which could activate MST1 via caspase-dependent cleavage.	Hydrogen Sulfide	30-33	macrophage stimulating 1	Homo sapiens	91-95
29088725-9	2017	This anti-apoptotic effect of H2S could be reversed by chelerythrine, which could activate MST1 via caspase-dependent cleavage.	chelerythrine	55-68	macrophage stimulating 1	Homo sapiens	91-95
29088725-10	2017	CONCLUSIONS: Exogenous NaHS, as a donor of H2S, could ameliorate early brain injury after SAH by inhibiting neuronal apoptosis by reducing the activity of the MST1 protein.	sodium bisulfide	23-27	macrophage stimulating 1	Homo sapiens	159-163
29088725-10	2017	CONCLUSIONS: Exogenous NaHS, as a donor of H2S, could ameliorate early brain injury after SAH by inhibiting neuronal apoptosis by reducing the activity of the MST1 protein.	Hydrogen Sulfide	43-46	macrophage stimulating 1	Homo sapiens	159-163
28487119-8	2017	Here, we report that serine 320 of the MST1 protein is a novel phosphorylation site for the anti-apoptotic protein kinase CK2.	Serine	21-27	macrophage stimulating 1	Homo sapiens	39-43
28366538-3	2017	In this study, we hypothesize that morin, a bioflavonoid, mediates its anti-cancer effect through the activation of Mst1/hippo signaling in liver cancer cells.	Flavonoids	44-56	macrophage stimulating 1	Homo sapiens	116-120
28373298-6	2017	We demonstrate that autophosphorylation of MST1 and MST2 on several threonine residues provides multiple MOB1 binding sites with varying binding affinities which in turn contribute to a redundancy of MST1-MOB1 protein interactions in cells.	Threonine	68-77	macrophage stimulating 1	Homo sapiens	43-47
28373298-6	2017	We demonstrate that autophosphorylation of MST1 and MST2 on several threonine residues provides multiple MOB1 binding sites with varying binding affinities which in turn contribute to a redundancy of MST1-MOB1 protein interactions in cells.	Threonine	68-77	macrophage stimulating 1	Homo sapiens	200-204
26538561-9	2015	Finally, we showed that treatment of Mst1(-/-) Tregs with Ex-527, a Sirt1-specific inhibitor, partially restored the suppressive function of Mst1(-/-) Tregs.	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	58-64	macrophage stimulating 1	Homo sapiens	37-41
27793648-8	2016	In addition, depletion of MST1 stimulates lactate production, whereas the specific depletion of TEAD1 has an opposite effect.	Lactic Acid	42-49	macrophage stimulating 1	Homo sapiens	26-30
27609031-2	2016	Macrophage-stimulating protein (MSP) is a hepatokine that potentially has a beneficial role in hepatic lipid and glucose metabolism via the activation of AMP-activated protein kinase (AMPK).	Glucose	113-120	macrophage stimulating 1	Homo sapiens	0-30
27609031-2	2016	Macrophage-stimulating protein (MSP) is a hepatokine that potentially has a beneficial role in hepatic lipid and glucose metabolism via the activation of AMP-activated protein kinase (AMPK).	Glucose	113-120	macrophage stimulating 1	Homo sapiens	32-35
27609031-5	2016	In addition, MSP treatment resulted in a significant reduction in PA-induced lipid accumulation and inhibited the gene expression of key lipogenic enzymes in HepG2 cells.	Palmitic Acid	66-68	macrophage stimulating 1	Homo sapiens	13-16
26698664-0	2016	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	Reactive Oxygen Species	46-69	macrophage stimulating 1	Homo sapiens	93-97
26698664-5	2016	Here, we showed that H2O2 induced the physical interaction between TRAF2 and MST1, and that this interaction promoted the homodimerization as well as the activation of MST1.	Hydrogen Peroxide	21-25	macrophage stimulating 1	Homo sapiens	77-81
26698664-5	2016	Here, we showed that H2O2 induced the physical interaction between TRAF2 and MST1, and that this interaction promoted the homodimerization as well as the activation of MST1.	Hydrogen Peroxide	21-25	macrophage stimulating 1	Homo sapiens	168-172
26698664-6	2016	Furthermore, TRAF2 was required for MST1 to mediate the H2O2-induced stimulation of c-Jun N-terminal kinase and p38 kinase as well as apoptosis.	Hydrogen Peroxide	56-60	macrophage stimulating 1	Homo sapiens	36-40
28327630-6	2017	A Rassf-Mst1 complexed version of the kinase becomes apoptotic by positively regulating Mst1-H2B mediated serine 14 histone H2B phosphorylation, a hallmark of chromatin condensation.	Serine	106-112	macrophage stimulating 1	Homo sapiens	8-12
28327630-6	2017	A Rassf-Mst1 complexed version of the kinase becomes apoptotic by positively regulating Mst1-H2B mediated serine 14 histone H2B phosphorylation, a hallmark of chromatin condensation.	Serine	106-112	macrophage stimulating 1	Homo sapiens	88-92
27825096-0	2016	Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.	Threonine	104-113	macrophage stimulating 1	Homo sapiens	39-43
27685150-4	2016	Additionally, MSP could reduce palmitic acid (PA)-induced lipid accumulation and lipogenesis in the HepG2 cell line.	Palmitic Acid	31-44	macrophage stimulating 1	Homo sapiens	14-17
27685150-4	2016	Additionally, MSP could reduce palmitic acid (PA)-induced lipid accumulation and lipogenesis in the HepG2 cell line.	Palmitic Acid	46-48	macrophage stimulating 1	Homo sapiens	14-17
26657153-6	2016	Mechanistically, we identified that MST1 could be acetylated on its lysine 35 residue in the cells.	Lysine	68-74	macrophage stimulating 1	Homo sapiens	36-40
26657153-7	2016	Strikingly, the treatment with trichostatin A, an inhibitor of histone deacetylases (HDACs), markedly increased the levels of MST1 acetylation and protein in the cells.	trichostatin A	31-45	macrophage stimulating 1	Homo sapiens	126-130
26538561-9	2015	Finally, we showed that treatment of Mst1(-/-) Tregs with Ex-527, a Sirt1-specific inhibitor, partially restored the suppressive function of Mst1(-/-) Tregs.	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	58-64	macrophage stimulating 1	Homo sapiens	141-145
25695629-3	2015	Intriguingly, attenuation of the UPR by tauroursodeoxycholic acid (TUDCA) diminishes Mst1/2 mutant-driven liver overgrowth and tumorigenesis by promoting nuclear exit and degradation of Hippo downstream effector Yap.	ursodoxicoltaurine	40-65	macrophage stimulating 1	Homo sapiens	85-91
26414765-0	2015	Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.	Reactive Oxygen Species	66-89	macrophage stimulating 1	Homo sapiens	8-12
26414765-3	2015	Here we found that the kinases Mst1 and Mst2 functioned to control ROS production by regulating mitochondrial trafficking and mitochondrion-phagosome juxtaposition.	Reactive Oxygen Species	67-70	macrophage stimulating 1	Homo sapiens	31-35
25843706-4	2015	mTORC2 phosphorylates MST1 at serine 438 in the SARAH domain, thereby reducing its homodimerization and activity.	Serine	30-36	macrophage stimulating 1	Homo sapiens	22-26
25315688-7	2015	In the in vivo study, 10 ng/mL MSP was applied to full-thickness skin wound with bacterial cellulose membranes, and this treatment could accelerate the wound healing rate and increased the collagen synthesis of wound sites.	Cellulose	91-100	macrophage stimulating 1	Homo sapiens	31-34
25695629-3	2015	Intriguingly, attenuation of the UPR by tauroursodeoxycholic acid (TUDCA) diminishes Mst1/2 mutant-driven liver overgrowth and tumorigenesis by promoting nuclear exit and degradation of Hippo downstream effector Yap.	ursodoxicoltaurine	67-72	macrophage stimulating 1	Homo sapiens	85-91
24732633-0	2014	Gemcitabine-induced pancreatic cancer cell death is associated with MST1/cyclophilin D mitochondrial complexation.	gemcitabine	0-11	macrophage stimulating 1	Homo sapiens	68-72
25685065-7	2015	The effect of RONDelta160 was significantly enhanced by induction of MSP inducing (p < 0.05).	rondelta160	14-25	macrophage stimulating 1	Homo sapiens	69-72
24732633-5	2014	Here we studied the mechanism of gemcitabine-induced pancreatic cancer cell death by focusing on mammalian sterile 20-like kinase 1 (MST1) and cyclophilin D (Cyp-D).	gemcitabine	33-44	macrophage stimulating 1	Homo sapiens	133-137
24732633-6	2014	We found that MST1 and Cyp-D expressions were significantly lower in gemcitabine-resistant pancreatic cancer tissues and cell lines.	gemcitabine	69-80	macrophage stimulating 1	Homo sapiens	14-18
24732633-7	2014	In vitro, gemcitabine activated MST1 through reactive oxygen species (ROS) production, which was prevented by antioxidant n-acetyl-cysteine (NAC).	gemcitabine	10-21	macrophage stimulating 1	Homo sapiens	32-36
24732633-7	2014	In vitro, gemcitabine activated MST1 through reactive oxygen species (ROS) production, which was prevented by antioxidant n-acetyl-cysteine (NAC).	Reactive Oxygen Species	45-68	macrophage stimulating 1	Homo sapiens	32-36
24732633-7	2014	In vitro, gemcitabine activated MST1 through reactive oxygen species (ROS) production, which was prevented by antioxidant n-acetyl-cysteine (NAC).	Reactive Oxygen Species	70-73	macrophage stimulating 1	Homo sapiens	32-36
24732633-7	2014	In vitro, gemcitabine activated MST1 through reactive oxygen species (ROS) production, which was prevented by antioxidant n-acetyl-cysteine (NAC).	Acetylcysteine	122-139	macrophage stimulating 1	Homo sapiens	32-36
24732633-7	2014	In vitro, gemcitabine activated MST1 through reactive oxygen species (ROS) production, which was prevented by antioxidant n-acetyl-cysteine (NAC).	Acetylcysteine	141-144	macrophage stimulating 1	Homo sapiens	32-36
24732633-8	2014	We found that gemcitabine-activated MST1 translocated to mitochondria and formed a complex with the local protein Cyp-D.	gemcitabine	14-25	macrophage stimulating 1	Homo sapiens	36-40
24732633-9	2014	Gemcitabine-induced cell death was alleviated by MST1 or Cyp-D shRNA silencing, but was aggravated by MST1 or Cyp-D over-expression.	gemcitabine	0-11	macrophage stimulating 1	Homo sapiens	49-53
24732633-9	2014	Gemcitabine-induced cell death was alleviated by MST1 or Cyp-D shRNA silencing, but was aggravated by MST1 or Cyp-D over-expression.	gemcitabine	0-11	macrophage stimulating 1	Homo sapiens	102-106
24732633-10	2014	Further, cyclosporin A (CsA), the Cyp-D inhibitor, prevented gemcitabine-induced MST1/Cyp-D mitochondrial complexation and cancer cell death.	Cyclosporine	24-27	macrophage stimulating 1	Homo sapiens	81-85
24732633-10	2014	Further, cyclosporin A (CsA), the Cyp-D inhibitor, prevented gemcitabine-induced MST1/Cyp-D mitochondrial complexation and cancer cell death.	gemcitabine	61-72	macrophage stimulating 1	Homo sapiens	81-85
24732633-11	2014	We suggest that gemcitabine-induced death of pancreatic cancer cells requires MST1/Cyp-D mitochondrial complexation.	gemcitabine	16-27	macrophage stimulating 1	Homo sapiens	78-82
24393845-2	2014	Here, we report that PHLPP1 is a binding protein for Mst1 and it modulates the Hippo pathway by dephosphorylating Mst1 at the inhibitory Thr(387) of Mst1.	Threonine	137-140	macrophage stimulating 1	Homo sapiens	53-57
24563371-11	2014	Further study demonstrated that NORE1A was capable of sensitising cancer cells to sorafenib-induced apoptosis via the activation of the Mst-1/Akt pathway.	Sorafenib	82-91	macrophage stimulating 1	Homo sapiens	136-141
24813943-5	2014	Activated Mst1 phosphorylates Bcl-xL at Ser14, which resides in the BH4 domain, thereby antagonizing Bcl-xL-Bax binding.	sapropterin	68-71	macrophage stimulating 1	Homo sapiens	10-14
24464935-4	2014	Treatment of cortical astrocytes with 170 microM H2O2 activated Mst1.	Hydrogen Peroxide	49-53	macrophage stimulating 1	Homo sapiens	64-68
24464935-5	2014	Knockdown of Mst1 reduced H2O2-induced cell death, indicating that Mst1 activation contributes to astrocytic cell death.	Hydrogen Peroxide	26-30	macrophage stimulating 1	Homo sapiens	13-17
24464935-5	2014	Knockdown of Mst1 reduced H2O2-induced cell death, indicating that Mst1 activation contributes to astrocytic cell death.	Hydrogen Peroxide	26-30	macrophage stimulating 1	Homo sapiens	67-71
24464935-6	2014	STI571, an inhibitor of cAbl, blocked induction/activation of Mst1 and H2O2-induced cell death.	Imatinib Mesylate	0-6	macrophage stimulating 1	Homo sapiens	62-66
24464935-8	2014	The zinc chelator TPEN blocked induction/activation of cAbl and Mst1, indicating that these phenomena are dependent on the rise of intracellular zinc.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	18-22	macrophage stimulating 1	Homo sapiens	64-68
24464935-10	2014	Consistent with the involvement of FoxO1/3, which may play a role in the Mst1-cell death cascade, we found an increase in the level of phosphorylated FoxO1/3 in H2O2-treated astrocytes.	Hydrogen Peroxide	161-165	macrophage stimulating 1	Homo sapiens	73-77
24393845-2	2014	Here, we report that PHLPP1 is a binding protein for Mst1 and it modulates the Hippo pathway by dephosphorylating Mst1 at the inhibitory Thr(387) of Mst1.	Threonine	137-140	macrophage stimulating 1	Homo sapiens	114-118
24393845-2	2014	Here, we report that PHLPP1 is a binding protein for Mst1 and it modulates the Hippo pathway by dephosphorylating Mst1 at the inhibitory Thr(387) of Mst1.	Threonine	137-140	macrophage stimulating 1	Homo sapiens	114-118
23485012-7	2013	The serine/threonine kinase Mst1, an amplifier of cell apoptosis, seemed to be a target of miR-138, and the activation of the Akt pathway was necessary for the anti-apoptotic effect of miR-138.	mir-138	91-98	macrophage stimulating 1	Homo sapiens	28-32
24255178-8	2013	Mutation of three basic amino acids that are part of a phospho-serine- and phospho-threonine-binding domain in human MOB1B prevented its interaction with MST1 and PP6 in cells treated with okadaic acid.	Amino Acids, Basic	18-35	macrophage stimulating 1	Homo sapiens	154-158
24255178-8	2013	Mutation of three basic amino acids that are part of a phospho-serine- and phospho-threonine-binding domain in human MOB1B prevented its interaction with MST1 and PP6 in cells treated with okadaic acid.	Serine	63-69	macrophage stimulating 1	Homo sapiens	154-158
24255178-8	2013	Mutation of three basic amino acids that are part of a phospho-serine- and phospho-threonine-binding domain in human MOB1B prevented its interaction with MST1 and PP6 in cells treated with okadaic acid.	Threonine	83-92	macrophage stimulating 1	Homo sapiens	154-158
24255178-8	2013	Mutation of three basic amino acids that are part of a phospho-serine- and phospho-threonine-binding domain in human MOB1B prevented its interaction with MST1 and PP6 in cells treated with okadaic acid.	Okadaic Acid	189-201	macrophage stimulating 1	Homo sapiens	154-158
23647599-8	2013	Indeed, upregulation of PCMT1 by CGP3466B, a compound related to the anti-Parkinson"s drug R-(-)-deprenyl with potent antiapoptotic effects, inhibited the hypoxia/reoxygenation induced Mst1 activation and cardiomyocyte apoptosis.	dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine	33-41	macrophage stimulating 1	Homo sapiens	185-189
24134840-0	2013	MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.	Curcumin	19-27	macrophage stimulating 1	Homo sapiens	0-4
24134840-1	2013	Different groups including ours have shown that curcumin induces melanoma cell apoptosis, here we focused the role of mammalian Sterile 20-like kinase 1 (MST1) in it.	Curcumin	48-56	macrophage stimulating 1	Homo sapiens	154-158
24134840-2	2013	We observed that curcumin activated MST1-dependent apoptosis in cultured melanoma cells.	Curcumin	17-25	macrophage stimulating 1	Homo sapiens	36-40
24134840-3	2013	MST1 silencing by RNA interference (RNAi) suppressed curcumin-induced cell apoptosis, while MST1 over-expressing increased curcumin sensitivity.	Curcumin	53-61	macrophage stimulating 1	Homo sapiens	0-4
24134840-3	2013	MST1 silencing by RNA interference (RNAi) suppressed curcumin-induced cell apoptosis, while MST1 over-expressing increased curcumin sensitivity.	Curcumin	123-131	macrophage stimulating 1	Homo sapiens	92-96
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Curcumin	11-19	macrophage stimulating 1	Homo sapiens	151-155
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Curcumin	11-19	macrophage stimulating 1	Homo sapiens	209-213
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Reactive Oxygen Species	96-99	macrophage stimulating 1	Homo sapiens	151-155
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Reactive Oxygen Species	96-99	macrophage stimulating 1	Homo sapiens	209-213
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Acetylcysteine	111-128	macrophage stimulating 1	Homo sapiens	151-155
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Acetylcysteine	111-128	macrophage stimulating 1	Homo sapiens	209-213
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Acetylcysteine	130-133	macrophage stimulating 1	Homo sapiens	151-155
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Acetylcysteine	130-133	macrophage stimulating 1	Homo sapiens	209-213
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Reactive Oxygen Species	96-99	macrophage stimulating 1	Homo sapiens	151-155
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Reactive Oxygen Species	96-99	macrophage stimulating 1	Homo sapiens	209-213
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	52-60	macrophage stimulating 1	Homo sapiens	78-82
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Acetylcysteine	117-120	macrophage stimulating 1	Homo sapiens	78-82
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Acetylcysteine	117-120	macrophage stimulating 1	Homo sapiens	90-94
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	139-147	macrophage stimulating 1	Homo sapiens	78-82
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	139-147	macrophage stimulating 1	Homo sapiens	90-94
24134840-6	2013	Further, curcumin induced Foxo3 nuclear translocation and Bim-1 (Foxo3 target gene) expression in melanoma cells, such an effect by curcumin was inhibited by MST1 RNAi.	Curcumin	9-17	macrophage stimulating 1	Homo sapiens	158-162
24134840-6	2013	Further, curcumin induced Foxo3 nuclear translocation and Bim-1 (Foxo3 target gene) expression in melanoma cells, such an effect by curcumin was inhibited by MST1 RNAi.	Curcumin	132-140	macrophage stimulating 1	Homo sapiens	158-162
24134840-7	2013	In conclusion, we suggested that MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.	Curcumin	52-60	macrophage stimulating 1	Homo sapiens	33-37
23726950-0	2013	Macrophage-stimulating protein attenuates hydrogen peroxide-induced apoptosis in human renal HK-2 cells.	Hydrogen Peroxide	42-59	macrophage stimulating 1	Homo sapiens	0-30
23726950-2	2013	We have investigated the role of MSP in hydrogen peroxide (H2O2)-induced renal tubular apoptosis.	Hydrogen Peroxide	40-57	macrophage stimulating 1	Homo sapiens	33-36
23726950-3	2013	Human renal proximal tubular (HK-2) cells were incubated with H2O2 for 24h in the presence of different concentrations of MSP, and cell viability was measured by MTT assay.	Hydrogen Peroxide	62-66	macrophage stimulating 1	Homo sapiens	122-125
23726950-6	2013	H2O2 treatment decreased cell viability in HK-2 cells; this was counteracted by MSP pretreatment.	Hydrogen Peroxide	0-4	macrophage stimulating 1	Homo sapiens	80-83
23726950-7	2013	H2O2 treatment induced an increased ratio of Bax/Bcl-2, cleaved caspase-3, and the number of condensed nuclei, which was also counteracted by MSP.	Hydrogen Peroxide	0-4	macrophage stimulating 1	Homo sapiens	142-145
23726950-8	2013	Flow cytometry analysis showed H2O2-induced apoptosis, and its prevention by MSP treatment.	Hydrogen Peroxide	31-35	macrophage stimulating 1	Homo sapiens	77-80
23726950-10	2013	H2O2 induced NF-kappaB activation and IkappaB-alpha degradation, but the increased nuclear NF-kappaB activation was counteracted by MSP or by a p38 MAPK inhibitor.	Hydrogen Peroxide	0-4	macrophage stimulating 1	Homo sapiens	132-135
23726950-11	2013	H2O2 treatment decreased expression of phospho-PI3K and phospho-Akt, which was reversed by MSP pretreatment.	Hydrogen Peroxide	0-4	macrophage stimulating 1	Homo sapiens	91-94
23726950-12	2013	These findings suggest that MSP attenuates H2O2-induced apoptosis in HK-2 cells by modulating the p38 and NF-kappaB, as well as PI3K/Akt, signaling pathways.	Hydrogen Peroxide	43-47	macrophage stimulating 1	Homo sapiens	28-31
23485012-7	2013	The serine/threonine kinase Mst1, an amplifier of cell apoptosis, seemed to be a target of miR-138, and the activation of the Akt pathway was necessary for the anti-apoptotic effect of miR-138.	mir-138	185-192	macrophage stimulating 1	Homo sapiens	28-32
24216995-6	2013	Proteins from the Ras association family (Rassf, especially Rassf1 and Rassf5) are tumor suppressors that are activated by Ras-GTP, triggering apoptosis via e.g., activation of mammalian sterile 20-like (MST1) kinase.	ras-gtp	123-130	macrophage stimulating 1	Homo sapiens	204-208
23419720-0	2013	Effect of Mst1 overexpression on the growth of human hepatocellular carcinoma HepG2 cells and the sensitivity to cisplatin in vitro.	Cisplatin	113-122	macrophage stimulating 1	Homo sapiens	10-14
23684612-6	2013	In contrast, activating YAP by deleting Mst1/Mst2 strongly protects against acetaminophen-induced liver injury.	Acetaminophen	76-89	macrophage stimulating 1	Homo sapiens	40-44
23583394-9	2013	GM reduced expression of anti-apoptotic protein Bcl-2 and induced expression of Bax and cleaved caspase 3; these effects and GM-induced expression of COX-2 and iNOS were also attenuated by MSP.	Gentamicins	125-127	macrophage stimulating 1	Homo sapiens	189-192
23583394-10	2013	GM caused MSP-reversible induction of phospho-ERK, phospho-JNK, and phospho-p38.	Gentamicins	0-2	macrophage stimulating 1	Homo sapiens	10-13
23583394-11	2013	GM induced NF-kappaB activation and degradation of IkappaB-alpha; the increase in nuclear NF-kappaB was blocked by inhibitors of ERK, JNK, p-38, or MSP pretreatment.	Gentamicins	0-2	macrophage stimulating 1	Homo sapiens	148-151
23583394-12	2013	These findings suggest that MSP attenuates GM-induced inflammation and apoptosis by inhibition of the MAPKs/NF-kappaB signaling pathways.	Gentamicins	43-45	macrophage stimulating 1	Homo sapiens	28-31
23583394-0	2013	Macrophage-stimulating protein attenuates gentamicin-induced inflammation and apoptosis in human renal proximal tubular epithelial cells.	Gentamicins	42-52	macrophage stimulating 1	Homo sapiens	0-30
23583394-1	2013	The present study aimed to investigate whether macrophage-stimulating protein (MSP) treatment attenuates renal apoptosis and inflammation in gentamicin (GM)-induced tubule injury and its underlying molecular mechanisms.	Gentamicins	141-151	macrophage stimulating 1	Homo sapiens	47-77
23583394-1	2013	The present study aimed to investigate whether macrophage-stimulating protein (MSP) treatment attenuates renal apoptosis and inflammation in gentamicin (GM)-induced tubule injury and its underlying molecular mechanisms.	Gentamicins	141-151	macrophage stimulating 1	Homo sapiens	79-82
23583394-1	2013	The present study aimed to investigate whether macrophage-stimulating protein (MSP) treatment attenuates renal apoptosis and inflammation in gentamicin (GM)-induced tubule injury and its underlying molecular mechanisms.	Gentamicins	153-155	macrophage stimulating 1	Homo sapiens	47-77
23583394-1	2013	The present study aimed to investigate whether macrophage-stimulating protein (MSP) treatment attenuates renal apoptosis and inflammation in gentamicin (GM)-induced tubule injury and its underlying molecular mechanisms.	Gentamicins	153-155	macrophage stimulating 1	Homo sapiens	79-82
23583394-3	2013	Human renal proximal tubular epithelial (HK-2) cells were incubated with GM for 24h in the presence of different concentrations of MSP and cell viability was measured by MTT assay.	Gentamicins	73-75	macrophage stimulating 1	Homo sapiens	131-134
23583394-6	2013	MSP and RON expression was significantly greater in GM-treated rats, than in untreated controls.	Gentamicins	52-54	macrophage stimulating 1	Homo sapiens	0-3
23583394-7	2013	GM-treatment reduced HK-2 cell viability, an effect that was counteracted by MSP.	Gentamicins	0-2	macrophage stimulating 1	Homo sapiens	77-80
23583394-8	2013	Flow cytometry and DAPI staining revealed GM-induced apoptosis was prevented by MSP.	DAPI	19-23	macrophage stimulating 1	Homo sapiens	80-83
23583394-8	2013	Flow cytometry and DAPI staining revealed GM-induced apoptosis was prevented by MSP.	Gentamicins	42-44	macrophage stimulating 1	Homo sapiens	80-83
23583394-9	2013	GM reduced expression of anti-apoptotic protein Bcl-2 and induced expression of Bax and cleaved caspase 3; these effects and GM-induced expression of COX-2 and iNOS were also attenuated by MSP.	Gentamicins	0-2	macrophage stimulating 1	Homo sapiens	189-192
23419720-4	2013	To investigate the effect of overexpression of Mst1 on the growth of human liver cancer cell line HepG2 cells and the sensitivity to cisplatin in vitro, here we constructed recombinant eukaryotic expression vector pEGFP-N1-Mst1 containing Mst1 gene, and transiently transfected into HepG2 cells.	Cisplatin	133-142	macrophage stimulating 1	Homo sapiens	47-51
23419720-7	2013	We also investigated the relationship between the expression and cleavage of Mst1 and cisplatin-induced cell death.	Cisplatin	86-95	macrophage stimulating 1	Homo sapiens	77-81
23419720-8	2013	We found that Mst1 overexpression could induce cisplatin chemosensitivity, and cisplatin could promote the cleavage of Mst1 without affecting the expression of Mst1.	Cisplatin	47-56	macrophage stimulating 1	Homo sapiens	14-18
23419720-8	2013	We found that Mst1 overexpression could induce cisplatin chemosensitivity, and cisplatin could promote the cleavage of Mst1 without affecting the expression of Mst1.	Cisplatin	79-88	macrophage stimulating 1	Homo sapiens	119-123
23419720-8	2013	We found that Mst1 overexpression could induce cisplatin chemosensitivity, and cisplatin could promote the cleavage of Mst1 without affecting the expression of Mst1.	Cisplatin	79-88	macrophage stimulating 1	Homo sapiens	119-123
23527007-7	2013	Chelerythrine, a potent inducer of apoptosis, substantially increased the nuclear translocation and interaction of GAPDH and Mst1 in cardiomyocytes.	chelerythrine	0-13	macrophage stimulating 1	Homo sapiens	125-129
23493077-4	2013	Okadaic acid has been frequently used to enhance the phosphorylation of MST1 and MST2 and to trigger the activation of the Hippo pathway.	Okadaic Acid	0-12	macrophage stimulating 1	Homo sapiens	72-76
23386615-1	2013	The serine/threonine protein kinases Mst1 and Mst2 can be activated by cellular stressors including hydrogen peroxide.	Hydrogen Peroxide	100-117	macrophage stimulating 1	Homo sapiens	37-41
23386615-3	2013	Mst1 inactivates Prdx1 by phosphorylating it at Thr-90 and Thr-183, leading to accumulation of hydrogen peroxide in cells.	Threonine	48-51	macrophage stimulating 1	Homo sapiens	0-4
23386615-3	2013	Mst1 inactivates Prdx1 by phosphorylating it at Thr-90 and Thr-183, leading to accumulation of hydrogen peroxide in cells.	Threonine	59-62	macrophage stimulating 1	Homo sapiens	0-4
23386615-3	2013	Mst1 inactivates Prdx1 by phosphorylating it at Thr-90 and Thr-183, leading to accumulation of hydrogen peroxide in cells.	Hydrogen Peroxide	95-112	macrophage stimulating 1	Homo sapiens	0-4
23386615-4	2013	These results suggest that hydrogen peroxide-stimulated Mst1 activates a positive feedback loop to sustain an oxidizing cellular state.	Hydrogen Peroxide	27-44	macrophage stimulating 1	Homo sapiens	56-60
23527007-8	2013	Overexpression of GAPDH significantly augmented the Mst1 mediated apoptosis, whereas knockdown of GAPDH markedly attenuated the Mst1 activation and cardiomyocyte apoptosis in response to either chelerythrine or hypoxia/reoxygenation.	chelerythrine	194-207	macrophage stimulating 1	Homo sapiens	128-132
23085515-3	2012	In this study, we found that thioredoxin-1 was physically associated with MST1 in intact cells and that this interaction was abolished by H2O2.	Hydrogen Peroxide	138-142	macrophage stimulating 1	Homo sapiens	74-78
23085515-6	2012	The effect of TNF-alpha on MST1 activation was reversed by the reducing agent N-acetyl-l-cysteine.	Acetylcysteine	78-97	macrophage stimulating 1	Homo sapiens	27-31
22912849-9	2012	Lastly, we demonstrate that higher merlin levels in human melanoma cells promote the H(2)O(2)-induced activation of MST1/2 Ser/Thr kinases, which are known tumor suppressors in the Hippo signaling pathway.	Hydrogen Peroxide	85-93	macrophage stimulating 1	Homo sapiens	116-122
22886217-4	2012	In order to knock down MST1 expression in HUVECs, cells were transfected with 100 nmol/L MST1 small interference RNA (siRNA) using Lipofectamine 2000 for 24 hours, and the transfection efficiency was analyzed by Western blot.	Lipofectamine	131-149	macrophage stimulating 1	Homo sapiens	89-93
22237417-4	2012	We expressed both MST1 gene variants (Arg(689) (MSP(wt)) and Cys(689) (MSP(mut)) in a eukaryotic cell system and compared their stimulatory effects on macrophage-like THP-1 cells.	Arginine	38-41	macrophage stimulating 1	Homo sapiens	18-22
22739148-4	2012	The results indicated that compared with the normal people, the expression level of MST1 in newly diagnosed patients with AL significantly decreased (P < 0.05), but significantly increased in AL patients with complete remission (CR), the difference of expression was statistically significant before CR and after CR (P < 0.05).	Chromium	232-234	macrophage stimulating 1	Homo sapiens	84-88
22739148-4	2012	The results indicated that compared with the normal people, the expression level of MST1 in newly diagnosed patients with AL significantly decreased (P < 0.05), but significantly increased in AL patients with complete remission (CR), the difference of expression was statistically significant before CR and after CR (P < 0.05).	Chromium	303-305	macrophage stimulating 1	Homo sapiens	84-88
22388075-0	2012	Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway.	Imatinib Mesylate	0-8	macrophage stimulating 1	Homo sapiens	113-117
22388075-7	2012	Meanwhile, imatinib (1-8 mumol/L) activated caspase-3 and its downstream mammalian STE20-like kinase 1 (Mst1), and induced apoptosis of K562 cells.	Imatinib Mesylate	11-19	macrophage stimulating 1	Homo sapiens	104-108
22388075-10	2012	CONCLUSION: The caspase-3/Mst1 pathway is required for H2AX C-terminal phosphorylation at Ser139 and Tyr142 and subsequent apoptosis in Bcr-Abl-positive K562 cells induced by imatinib.	Imatinib Mesylate	175-183	macrophage stimulating 1	Homo sapiens	26-30
22619175-3	2012	Here, we characterized the effects of phospho-Thr-120 on Mst1 in prostate cancer cells.	Threonine	46-49	macrophage stimulating 1	Homo sapiens	57-61
22619175-6	2012	In contrast, phospho-Thr-183, a critical regulator of Mst1 cell death, was exclusively found in the cytoplasm.	Threonine	21-24	macrophage stimulating 1	Homo sapiens	54-58
22619175-7	2012	As assessed by immunohistochemistry, a similar distribution of phospho-Mst1-Thr-120/Thr-183 was also observed in a prostate cancer specimen.	Threonine	76-79	macrophage stimulating 1	Homo sapiens	71-75
22619175-8	2012	In addition, the blockade of PI3K signaling by a small molecule inhibitor, LY294002, increased cytoplasmic phospho-Mst1-Thr-183 without having a significant effect on nuclear phospho-Mst1-Thr-120.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	macrophage stimulating 1	Homo sapiens	115-119
22619175-8	2012	In addition, the blockade of PI3K signaling by a small molecule inhibitor, LY294002, increased cytoplasmic phospho-Mst1-Thr-183 without having a significant effect on nuclear phospho-Mst1-Thr-120.	Threonine	120-123	macrophage stimulating 1	Homo sapiens	115-119
22619175-9	2012	However, the attenuation of mammalian target of rapamycin (mTOR) activity by a selective pharmacologic inhibitor, Ku0063794 or CCI-779, caused the up-regulation of nuclear phospho-Mst1-Thr-120 without affecting cytoplasmic phospho-Mst1-Thr-183.	Ku 0063794	114-123	macrophage stimulating 1	Homo sapiens	180-184
22619175-9	2012	However, the attenuation of mammalian target of rapamycin (mTOR) activity by a selective pharmacologic inhibitor, Ku0063794 or CCI-779, caused the up-regulation of nuclear phospho-Mst1-Thr-120 without affecting cytoplasmic phospho-Mst1-Thr-183.	Ku 0063794	114-123	macrophage stimulating 1	Homo sapiens	231-235
22619175-9	2012	However, the attenuation of mammalian target of rapamycin (mTOR) activity by a selective pharmacologic inhibitor, Ku0063794 or CCI-779, caused the up-regulation of nuclear phospho-Mst1-Thr-120 without affecting cytoplasmic phospho-Mst1-Thr-183.	temsirolimus	127-134	macrophage stimulating 1	Homo sapiens	180-184
22619175-9	2012	However, the attenuation of mammalian target of rapamycin (mTOR) activity by a selective pharmacologic inhibitor, Ku0063794 or CCI-779, caused the up-regulation of nuclear phospho-Mst1-Thr-120 without affecting cytoplasmic phospho-Mst1-Thr-183.	temsirolimus	127-134	macrophage stimulating 1	Homo sapiens	231-235
22619175-9	2012	However, the attenuation of mammalian target of rapamycin (mTOR) activity by a selective pharmacologic inhibitor, Ku0063794 or CCI-779, caused the up-regulation of nuclear phospho-Mst1-Thr-120 without affecting cytoplasmic phospho-Mst1-Thr-183.	Threonine	185-188	macrophage stimulating 1	Homo sapiens	180-184
22619175-9	2012	However, the attenuation of mammalian target of rapamycin (mTOR) activity by a selective pharmacologic inhibitor, Ku0063794 or CCI-779, caused the up-regulation of nuclear phospho-Mst1-Thr-120 without affecting cytoplasmic phospho-Mst1-Thr-183.	Threonine	236-239	macrophage stimulating 1	Homo sapiens	180-184
22619175-10	2012	This suggests that PI3K and mTOR pathway signaling differentially regulate phospho-Mst1-Thr-120/Thr-183.	Threonine	88-91	macrophage stimulating 1	Homo sapiens	83-87
22619175-10	2012	This suggests that PI3K and mTOR pathway signaling differentially regulate phospho-Mst1-Thr-120/Thr-183.	Threonine	96-99	macrophage stimulating 1	Homo sapiens	83-87
22619175-11	2012	Moreover, mutagenesis and RNAi data revealed that phospho-Thr-120 resulted in C4-2 cell resistance to mTOR inhibition and reduced the Mst1 suppression of cell growth and androgen receptor-driven gene expression.	Threonine	58-61	macrophage stimulating 1	Homo sapiens	134-138
22619175-12	2012	Collectively, these findings indicate that phospho-Thr-120 leads to the loss of Mst1 functions, supporting cancer cell growth and survival.	Threonine	51-54	macrophage stimulating 1	Homo sapiens	80-84
21799973-2	2011	In this report, two sonochemical methods (S1 and S2) were used to prepare highly dispersed Ru catalysts supported on mesoporous TiO(2) (TiO(2)(MSP)) for the PROX reaction, in which a reaction gas mixture containing 1% CO + 1% O(2) + 18% CO(2) + 78% H(2) was used.	mesoporous	117-127	macrophage stimulating 1	Homo sapiens	136-147
21516123-1	2011	Mammalian Ste20-like kinase-1 (MST1) kinase mediates H2O2-induced cell death by anticancer drugs such as cisplatin in a p53-dependent manner.	Hydrogen Peroxide	53-57	macrophage stimulating 1	Homo sapiens	31-35
21516123-1	2011	Mammalian Ste20-like kinase-1 (MST1) kinase mediates H2O2-induced cell death by anticancer drugs such as cisplatin in a p53-dependent manner.	Cisplatin	105-114	macrophage stimulating 1	Homo sapiens	31-35
21516123-2	2011	However, the mechanism underlying MST1 activation by H2O2 remains unknown.	Hydrogen Peroxide	53-57	macrophage stimulating 1	Homo sapiens	34-38
21516123-3	2011	Here we show that peroxiredoxin-I (PRX-I) is an essential intermediate in H2O2-induced MST1 activation and cisplatin-induced cell death through p53.	Hydrogen Peroxide	74-78	macrophage stimulating 1	Homo sapiens	87-91
21516123-4	2011	Cell stimulation with H2O2 resulted in PRX-I oxidation to form homo-oligomers and interaction with MST1, leading to MST1 autophosphorylation and augmentation of kinase activity.	Hydrogen Peroxide	22-26	macrophage stimulating 1	Homo sapiens	99-103
21516123-4	2011	Cell stimulation with H2O2 resulted in PRX-I oxidation to form homo-oligomers and interaction with MST1, leading to MST1 autophosphorylation and augmentation of kinase activity.	Hydrogen Peroxide	22-26	macrophage stimulating 1	Homo sapiens	116-120
21516123-5	2011	In addition, RNA interference knockdown experiments indicated that endogenous PRX-I is required for H2O2-induced MST1 activation.	Hydrogen Peroxide	100-104	macrophage stimulating 1	Homo sapiens	113-117
21516123-6	2011	Live-cell imaging showed H2O2 generation by cisplatin treatment, which likewise caused PRX-I oligomer formation, MST1 activation and cell death.	Hydrogen Peroxide	25-29	macrophage stimulating 1	Homo sapiens	113-117
21516123-6	2011	Live-cell imaging showed H2O2 generation by cisplatin treatment, which likewise caused PRX-I oligomer formation, MST1 activation and cell death.	Cisplatin	44-53	macrophage stimulating 1	Homo sapiens	113-117
21516123-9	2011	Moreover, we succeeded in reconstituting H2O2-induced MST1 activation in vitro, using purified PRX-I and MST1 proteins.	Hydrogen Peroxide	41-45	macrophage stimulating 1	Homo sapiens	54-58
21516123-9	2011	Moreover, we succeeded in reconstituting H2O2-induced MST1 activation in vitro, using purified PRX-I and MST1 proteins.	Hydrogen Peroxide	41-45	macrophage stimulating 1	Homo sapiens	105-109
23029267-3	2012	Using our newly designed live cell FRET time-lapse imaging, we found that post-metaphase RanGTP is crucial in the maintenance of stable kinetochore-microtubule attachments by regulating Aurora B kinase via the NES-bearing Mst1.	rangtp	89-95	macrophage stimulating 1	Homo sapiens	222-226
21799973-2	2011	In this report, two sonochemical methods (S1 and S2) were used to prepare highly dispersed Ru catalysts supported on mesoporous TiO(2) (TiO(2)(MSP)) for the PROX reaction, in which a reaction gas mixture containing 1% CO + 1% O(2) + 18% CO(2) + 78% H(2) was used.	titanium dioxide	128-134	macrophage stimulating 1	Homo sapiens	136-147
21799973-2	2011	In this report, two sonochemical methods (S1 and S2) were used to prepare highly dispersed Ru catalysts supported on mesoporous TiO(2) (TiO(2)(MSP)) for the PROX reaction, in which a reaction gas mixture containing 1% CO + 1% O(2) + 18% CO(2) + 78% H(2) was used.	Carbon Monoxide	218-220	macrophage stimulating 1	Homo sapiens	136-147
21799973-2	2011	In this report, two sonochemical methods (S1 and S2) were used to prepare highly dispersed Ru catalysts supported on mesoporous TiO(2) (TiO(2)(MSP)) for the PROX reaction, in which a reaction gas mixture containing 1% CO + 1% O(2) + 18% CO(2) + 78% H(2) was used.	o(2)	130-134	macrophage stimulating 1	Homo sapiens	136-147
21799973-2	2011	In this report, two sonochemical methods (S1 and S2) were used to prepare highly dispersed Ru catalysts supported on mesoporous TiO(2) (TiO(2)(MSP)) for the PROX reaction, in which a reaction gas mixture containing 1% CO + 1% O(2) + 18% CO(2) + 78% H(2) was used.	co(2)	237-242	macrophage stimulating 1	Homo sapiens	136-147
21799973-2	2011	In this report, two sonochemical methods (S1 and S2) were used to prepare highly dispersed Ru catalysts supported on mesoporous TiO(2) (TiO(2)(MSP)) for the PROX reaction, in which a reaction gas mixture containing 1% CO + 1% O(2) + 18% CO(2) + 78% H(2) was used.	h(2)	249-253	macrophage stimulating 1	Homo sapiens	136-147
21799973-4	2011	The Ru/TiO(2)(MSP) catalysts were active for the PROX reaction below 200  C and good for the methanation reactions of CO and CO(2) above 200  C. The presence of residual chlorine in the catalysts severely suppressed their PROX reaction activity, and a higher dispersion of Ru particles led to better catalytic performances.	Carbon Monoxide	118-120	macrophage stimulating 1	Homo sapiens	7-18
21799973-4	2011	The Ru/TiO(2)(MSP) catalysts were active for the PROX reaction below 200  C and good for the methanation reactions of CO and CO(2) above 200  C. The presence of residual chlorine in the catalysts severely suppressed their PROX reaction activity, and a higher dispersion of Ru particles led to better catalytic performances.	co(2)	125-130	macrophage stimulating 1	Homo sapiens	7-18
21799973-4	2011	The Ru/TiO(2)(MSP) catalysts were active for the PROX reaction below 200  C and good for the methanation reactions of CO and CO(2) above 200  C. The presence of residual chlorine in the catalysts severely suppressed their PROX reaction activity, and a higher dispersion of Ru particles led to better catalytic performances.	Chlorine	170-178	macrophage stimulating 1	Homo sapiens	7-18
21799973-4	2011	The Ru/TiO(2)(MSP) catalysts were active for the PROX reaction below 200  C and good for the methanation reactions of CO and CO(2) above 200  C. The presence of residual chlorine in the catalysts severely suppressed their PROX reaction activity, and a higher dispersion of Ru particles led to better catalytic performances.	Ruthenium	4-6	macrophage stimulating 1	Homo sapiens	7-18
21799973-5	2011	The addition of Au in the Ru/TiO(2)(MSP) catalyst also caused a poorer catalytic activity for both the PROX and the methanation reactions.	Gold	16-18	macrophage stimulating 1	Homo sapiens	29-40
21799973-6	2011	TPR results showed that in the active catalysts prepared by the S1 and S2 methods, the well dispersed Ru particles, after calcination in air, had a stronger interaction with the support than those in the catalyst prepared by the impregnation method and in the Au-Ru/TiO(2)(MSP) catalyst.	Ruthenium	102-104	macrophage stimulating 1	Homo sapiens	266-277
21909427-3	2011	MST1/Lats kinase inhibits YAP2"s nuclear accumulation and transcriptional activity through inducing the phosphorylation at serine 127 and the sequential association with 14-3-3 proteins.	Serine	123-129	macrophage stimulating 1	Homo sapiens	0-4
21528357-6	2011	RESULTS: MSP markedly inhibited expression of inflammatory cytokines (IL-1beta, TNF-alpha and IL-18), chemokines (MIP-1, MCP-1 and RANTES) and iNOS, NO, COX-2 and PGE(2) in RASF stimulated by LPS.	Prostaglandins E	163-166	macrophage stimulating 1	Homo sapiens	9-12
21245099-6	2011	Furthermore, the proapoptotic kinase Hippo/Mst1 was found to be strongly activated by alpha-TOS, and inhibiting Hippo/Mst1 by specific siRNA prevented phosphorylation of FoxO1 and its nuclear translocation, thereby reducing levels of NOXA transcription and apoptosis in cancer cells exposed to alpha-TOS.	alpha-Tocopherol	86-95	macrophage stimulating 1	Homo sapiens	43-47
21245099-6	2011	Furthermore, the proapoptotic kinase Hippo/Mst1 was found to be strongly activated by alpha-TOS, and inhibiting Hippo/Mst1 by specific siRNA prevented phosphorylation of FoxO1 and its nuclear translocation, thereby reducing levels of NOXA transcription and apoptosis in cancer cells exposed to alpha-TOS.	alpha-Tocopherol	86-95	macrophage stimulating 1	Homo sapiens	118-122
21245099-6	2011	Furthermore, the proapoptotic kinase Hippo/Mst1 was found to be strongly activated by alpha-TOS, and inhibiting Hippo/Mst1 by specific siRNA prevented phosphorylation of FoxO1 and its nuclear translocation, thereby reducing levels of NOXA transcription and apoptosis in cancer cells exposed to alpha-TOS.	alpha-Tocopherol	294-303	macrophage stimulating 1	Homo sapiens	43-47
21245099-6	2011	Furthermore, the proapoptotic kinase Hippo/Mst1 was found to be strongly activated by alpha-TOS, and inhibiting Hippo/Mst1 by specific siRNA prevented phosphorylation of FoxO1 and its nuclear translocation, thereby reducing levels of NOXA transcription and apoptosis in cancer cells exposed to alpha-TOS.	alpha-Tocopherol	294-303	macrophage stimulating 1	Homo sapiens	118-122
21199877-2	2011	Okadaic acid treatment and PP2A knockdown promoted MST1/2 phosphorylation.	Okadaic Acid	0-12	macrophage stimulating 1	Homo sapiens	51-55
21199877-3	2011	Data from dephosphorylation assays and reduced activation of MST1/2 seen after RASSF1A depletion suggest that dephosphorylation of MST1/2 on Thr-183 and Thr-180 by PP2A is prevented by RASSF1A, shifting the balance of MST1/2 to the activated autophosphorylated form.	Threonine	141-144	macrophage stimulating 1	Homo sapiens	61-67
21199877-3	2011	Data from dephosphorylation assays and reduced activation of MST1/2 seen after RASSF1A depletion suggest that dephosphorylation of MST1/2 on Thr-183 and Thr-180 by PP2A is prevented by RASSF1A, shifting the balance of MST1/2 to the activated autophosphorylated form.	Threonine	141-144	macrophage stimulating 1	Homo sapiens	131-137
21199877-3	2011	Data from dephosphorylation assays and reduced activation of MST1/2 seen after RASSF1A depletion suggest that dephosphorylation of MST1/2 on Thr-183 and Thr-180 by PP2A is prevented by RASSF1A, shifting the balance of MST1/2 to the activated autophosphorylated form.	Threonine	141-144	macrophage stimulating 1	Homo sapiens	131-137
21199877-3	2011	Data from dephosphorylation assays and reduced activation of MST1/2 seen after RASSF1A depletion suggest that dephosphorylation of MST1/2 on Thr-183 and Thr-180 by PP2A is prevented by RASSF1A, shifting the balance of MST1/2 to the activated autophosphorylated form.	Threonine	153-156	macrophage stimulating 1	Homo sapiens	61-67
21199877-3	2011	Data from dephosphorylation assays and reduced activation of MST1/2 seen after RASSF1A depletion suggest that dephosphorylation of MST1/2 on Thr-183 and Thr-180 by PP2A is prevented by RASSF1A, shifting the balance of MST1/2 to the activated autophosphorylated form.	Threonine	153-156	macrophage stimulating 1	Homo sapiens	131-137
21199877-3	2011	Data from dephosphorylation assays and reduced activation of MST1/2 seen after RASSF1A depletion suggest that dephosphorylation of MST1/2 on Thr-183 and Thr-180 by PP2A is prevented by RASSF1A, shifting the balance of MST1/2 to the activated autophosphorylated form.	Threonine	153-156	macrophage stimulating 1	Homo sapiens	131-137
20602268-3	2010	Specifically H2B phosphorylation at serine 14 (Ser14) catalyzed by Mst1 kinase has been linked to chromatin condensation during apoptosis.	Serine	36-42	macrophage stimulating 1	Homo sapiens	67-71
20921231-3	2010	Here we show that MST1 induces apoptotic chromatin condensation through its phosphorylation of histone H2AX at Ser-139.	Serine	111-114	macrophage stimulating 1	Homo sapiens	18-22
20921231-4	2010	During etoposide-induced apoptosis in Jurkat cells, the cleavage of MST1 directly corresponded with strong H2AX phosphorylation.	Etoposide	7-16	macrophage stimulating 1	Homo sapiens	68-72
20921231-6	2010	Western blot and kinase assay results with a mutant S139A H2AX confirmed that MST1 phosphorylates H2AX at Ser-139.	Serine	106-109	macrophage stimulating 1	Homo sapiens	78-82
20921231-9	2010	The caspase-3 inhibitor benzyloxycarbonyl-DEVD-fluoromethyl ketone (Z-DEVD-fmk) attenuates phosphorylation of H2AX by MST1 but cannot inhibit MST1-NT-induced histone H2AX phosphorylation, indicating that cleaved MST1 is responsible for H2AX phosphorylation during apoptosis.	benzyloxycarbonyl-devd-fluoromethyl ketone	24-66	macrophage stimulating 1	Homo sapiens	118-122
20921231-9	2010	The caspase-3 inhibitor benzyloxycarbonyl-DEVD-fluoromethyl ketone (Z-DEVD-fmk) attenuates phosphorylation of H2AX by MST1 but cannot inhibit MST1-NT-induced histone H2AX phosphorylation, indicating that cleaved MST1 is responsible for H2AX phosphorylation during apoptosis.	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	68-78	macrophage stimulating 1	Homo sapiens	118-122
20921231-10	2010	Histone H2AX phosphorylation and DNA fragmentation were suppressed in MST1 knockdown Jurkat cells after etoposide treatment.	Etoposide	104-113	macrophage stimulating 1	Homo sapiens	70-74
20437784-2	2010	The CO2 adsorption capacity of MSP and MSP (EDA) increased with temperature from 20 to 60 degrees C but decreased with temperature from 60 to 100 degrees C. The mechanism of CO2 adsorption on both samples is mainly attributed to physical interaction regardless of temperature change.	Carbon Dioxide	4-7	macrophage stimulating 1	Homo sapiens	31-34
20437784-2	2010	The CO2 adsorption capacity of MSP and MSP (EDA) increased with temperature from 20 to 60 degrees C but decreased with temperature from 60 to 100 degrees C. The mechanism of CO2 adsorption on both samples is mainly attributed to physical interaction regardless of temperature change.	Carbon Dioxide	4-7	macrophage stimulating 1	Homo sapiens	39-42
20437784-2	2010	The CO2 adsorption capacity of MSP and MSP (EDA) increased with temperature from 20 to 60 degrees C but decreased with temperature from 60 to 100 degrees C. The mechanism of CO2 adsorption on both samples is mainly attributed to physical interaction regardless of temperature change.	Carbon Dioxide	174-177	macrophage stimulating 1	Homo sapiens	31-34
20437784-2	2010	The CO2 adsorption capacity of MSP and MSP (EDA) increased with temperature from 20 to 60 degrees C but decreased with temperature from 60 to 100 degrees C. The mechanism of CO2 adsorption on both samples is mainly attributed to physical interaction regardless of temperature change.	Carbon Dioxide	174-177	macrophage stimulating 1	Homo sapiens	39-42
20437784-3	2010	The MSP (EDA) have good adsorption performance as compared with EDA-modified zeolite or granular activated carbon conducted in this study and many types of silica sorbents reported in the literature.	aminoethyl-aminopropyl-trimethoxysilane	9-12	macrophage stimulating 1	Homo sapiens	4-7
20437784-3	2010	The MSP (EDA) have good adsorption performance as compared with EDA-modified zeolite or granular activated carbon conducted in this study and many types of silica sorbents reported in the literature.	Silicon Dioxide	156-162	macrophage stimulating 1	Homo sapiens	4-7
20437784-4	2010	The cyclic CO2 adsorption showed that spent MSP (EDA) could be effectively regenerated at 120 degrees C for 25 min and CO2 adsorption capacity of MSP (EDA) was preserved during 16 cycles of adsorption and thermal regeneration.	Carbon Dioxide	11-14	macrophage stimulating 1	Homo sapiens	44-47
20437784-4	2010	The cyclic CO2 adsorption showed that spent MSP (EDA) could be effectively regenerated at 120 degrees C for 25 min and CO2 adsorption capacity of MSP (EDA) was preserved during 16 cycles of adsorption and thermal regeneration.	Carbon Dioxide	11-14	macrophage stimulating 1	Homo sapiens	146-149
20437784-4	2010	The cyclic CO2 adsorption showed that spent MSP (EDA) could be effectively regenerated at 120 degrees C for 25 min and CO2 adsorption capacity of MSP (EDA) was preserved during 16 cycles of adsorption and thermal regeneration.	Carbon Dioxide	119-122	macrophage stimulating 1	Homo sapiens	44-47
20437784-4	2010	The cyclic CO2 adsorption showed that spent MSP (EDA) could be effectively regenerated at 120 degrees C for 25 min and CO2 adsorption capacity of MSP (EDA) was preserved during 16 cycles of adsorption and thermal regeneration.	Carbon Dioxide	119-122	macrophage stimulating 1	Homo sapiens	146-149
20437784-5	2010	These results suggests that MSP (EDA) are efficient CO2 sorbents and can be stably used in the prolonged cyclic operation.	Carbon Dioxide	52-55	macrophage stimulating 1	Homo sapiens	28-31
19221179-2	2009	Recent studies suggest that MST1 mediates oxidative stress-induced neuronal cell death by phosphorylating the transcription factor FOXO3 at serine 207, a site that is conserved in other FOXO family members.	Serine	140-146	macrophage stimulating 1	Homo sapiens	28-32
19940129-2	2010	MST1 exerts pro-apoptotic function through cleavage, autophosphorylation-Thr(183) and subsequent translocation to the nucleus where it phosphorylates a number of molecules, including LATS1/2, FOXO, JNK, and histone H2B.	Threonine	73-76	macrophage stimulating 1	Homo sapiens	0-4
19940129-3	2010	Here, we show that the cleavage of MST1 is inhibited by the phosphatidylinositol 3-kinase/Akt pathway.	Phosphatidylinositols	60-80	macrophage stimulating 1	Homo sapiens	35-39
19940129-4	2010	Akt interacts with MST1 and phosphorylates a highly conserved residue threonine 120 of MST1, which leads to inhibition of its kinase activity and nuclear translocation as well as the autophosphorylation of Thr(183).	Threonine	70-79	macrophage stimulating 1	Homo sapiens	19-23
19940129-4	2010	Akt interacts with MST1 and phosphorylates a highly conserved residue threonine 120 of MST1, which leads to inhibition of its kinase activity and nuclear translocation as well as the autophosphorylation of Thr(183).	Threonine	70-79	macrophage stimulating 1	Homo sapiens	87-91
19940129-4	2010	Akt interacts with MST1 and phosphorylates a highly conserved residue threonine 120 of MST1, which leads to inhibition of its kinase activity and nuclear translocation as well as the autophosphorylation of Thr(183).	Threonine	206-209	macrophage stimulating 1	Homo sapiens	19-23
19940129-4	2010	Akt interacts with MST1 and phosphorylates a highly conserved residue threonine 120 of MST1, which leads to inhibition of its kinase activity and nuclear translocation as well as the autophosphorylation of Thr(183).	Threonine	206-209	macrophage stimulating 1	Homo sapiens	87-91
19940129-5	2010	Phospho-MST1-Thr(120) failed to activate downstream targets FOXO3a and JNK.	Threonine	13-16	macrophage stimulating 1	Homo sapiens	8-12
19940129-7	2010	These findings indicate that the phosphorylation of MST1-Thr(120) by Akt could be a major mechanism of regulation of the Hippo/MST1 pathway by cell survival signaling.	Threonine	57-60	macrophage stimulating 1	Homo sapiens	52-56
19940129-7	2010	These findings indicate that the phosphorylation of MST1-Thr(120) by Akt could be a major mechanism of regulation of the Hippo/MST1 pathway by cell survival signaling.	Threonine	57-60	macrophage stimulating 1	Homo sapiens	127-131
20028971-0	2010	c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82.	Serine	98-104	macrophage stimulating 1	Homo sapiens	33-37
20028971-5	2010	In this study, we report that JNK (c-Jun N-terminal kinase) phosphorylates MST1 at serine 82, which leads to the enhancement of MST1 activation.	Serine	83-89	macrophage stimulating 1	Homo sapiens	75-79
20028971-5	2010	In this study, we report that JNK (c-Jun N-terminal kinase) phosphorylates MST1 at serine 82, which leads to the enhancement of MST1 activation.	Serine	83-89	macrophage stimulating 1	Homo sapiens	128-132
20028971-6	2010	Accordingly, the activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death.	Serine	60-66	macrophage stimulating 1	Homo sapiens	31-35
20028971-8	2010	We also find the S82A (serine mutated to alanine) diminishes MST1 activation and its effect on the FOXO transcription activity.	Serine	23-29	macrophage stimulating 1	Homo sapiens	61-65
20028971-8	2010	We also find the S82A (serine mutated to alanine) diminishes MST1 activation and its effect on the FOXO transcription activity.	Alanine	41-48	macrophage stimulating 1	Homo sapiens	61-65
19940129-0	2010	Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.	Threonine	104-113	macrophage stimulating 1	Homo sapiens	39-43
19221179-3	2009	Here, we show that MST1-induced phosphorylation of FOXO1 at serine 212, corresponding to serine 207 in FOXO3, disrupts the association of FOXO1 with 14-3-3 proteins.	Serine	60-66	macrophage stimulating 1	Homo sapiens	19-23
19221179-3	2009	Here, we show that MST1-induced phosphorylation of FOXO1 at serine 212, corresponding to serine 207 in FOXO3, disrupts the association of FOXO1 with 14-3-3 proteins.	Serine	89-95	macrophage stimulating 1	Homo sapiens	19-23
18986304-7	2009	MS analysis indicated that Mst1 phosphorylates cTnI at Thr(31), Thr(51), Thr(129) and Thr(143).	Threonine	55-58	macrophage stimulating 1	Homo sapiens	27-31
19226137-2	2009	In this study, we report on the development of a potent and selective MST1 kinase inhibitor based on a ruthenium half-sandwich scaffold.	Ruthenium	103-112	macrophage stimulating 1	Homo sapiens	70-74
19226137-3	2009	We show that the enantiopure organoruthenium inhibitor, 9E1, has an IC50 value of 45 nM for MST1 and a greater than 25-fold inhibitor selectivity over the related Ste-20 kinases, p21 activated kinase 1 (PAK1), and p21 activated kinase 4 (PAK4) and an almost 10-fold selectivity over the related thousand-and-one amino acids kinase 2 (TAO2).	organoruthenium	29-44	macrophage stimulating 1	Homo sapiens	92-96
18986304-7	2009	MS analysis indicated that Mst1 phosphorylates cTnI at Thr(31), Thr(51), Thr(129) and Thr(143).	Threonine	64-67	macrophage stimulating 1	Homo sapiens	27-31
18986304-7	2009	MS analysis indicated that Mst1 phosphorylates cTnI at Thr(31), Thr(51), Thr(129) and Thr(143).	Threonine	64-67	macrophage stimulating 1	Homo sapiens	27-31
18986304-7	2009	MS analysis indicated that Mst1 phosphorylates cTnI at Thr(31), Thr(51), Thr(129) and Thr(143).	Threonine	64-67	macrophage stimulating 1	Homo sapiens	27-31
18986304-8	2009	Substitution of Thr(31) with an alanine residue reduced Mst1-mediated cTnI phosphorylation by 90%, whereas replacement of Thr(51), Thr(129) or Thr(143) with alanine residues reduced Mst1-catalysed cTnI phosphorylation by approx.	Threonine	16-19	macrophage stimulating 1	Homo sapiens	56-60
18986304-9	2009	60%, suggesting that Thr(31) is a preferential phosphorylation site for Mst1.	Threonine	21-24	macrophage stimulating 1	Homo sapiens	72-76
18986304-10	2009	Furthermore, treatment of cardiomyocytes with hydrogen peroxide rapidly induced Mst1-dependent phosphorylation of cTnI at Thr(31).	Hydrogen Peroxide	46-63	macrophage stimulating 1	Homo sapiens	80-84
18986304-10	2009	Furthermore, treatment of cardiomyocytes with hydrogen peroxide rapidly induced Mst1-dependent phosphorylation of cTnI at Thr(31).	Threonine	122-125	macrophage stimulating 1	Homo sapiens	80-84
18614774-4	2008	In vitro, MSP stimulated tubular epithelial cell proliferation and conferred resistance to cisplatin-induced apoptosis by inhibiting caspase activation and modulating Fas, mitochondrial proteins, Akt, and extracellular signal-regulated kinase.	Cisplatin	91-100	macrophage stimulating 1	Homo sapiens	10-13
19060893-3	2009	Furthermore, the expression of phosphomimetic histone H2B or caspase-activated Mst1 immobilizes RCC1 and causes reduction of nuclear RanGTP levels, which leads to inactivation of the nuclear transport machinery.	rangtp	133-139	macrophage stimulating 1	Homo sapiens	79-83
19060893-6	2009	Therefore, we propose that RCC1 reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus.	rangtp	136-142	macrophage stimulating 1	Homo sapiens	84-88
18593918-4	2008	Significantly, curcumin-mediated inhibition of RON expression resulted in the blockade of RON ligand, MSP-induced invasion of breast cancer cells.	Curcumin	15-23	macrophage stimulating 1	Homo sapiens	102-105
18593918-8	2008	Treatment of MDA-MB-231 cells with pyrrolidine dithiocarbamate, an inhibitor of p65, or small interfering RNA knockdown of p65, blocked RON gene expression and MSP-mediated invasion of MDA-MB-231 cells.	pyrrolidine dithiocarbamic acid	35-62	macrophage stimulating 1	Homo sapiens	160-163
18165235-10	2008	Treatment of MDA MB 231 cells with mithramycin A, an inhibitor of Sp1 binding, or siRNA knock-down of Sp1 blocked RON gene expression and MSP-mediated invasion of MDA MB 231 cells.	mithramycin A	35-48	macrophage stimulating 1	Homo sapiens	138-141
18381433-10	2008	The higher levels of Hsp70 induction and subsequent Mst1 degradation mediate cisplatin resistance in prostate cancer DU145 cells.	Cisplatin	77-86	macrophage stimulating 1	Homo sapiens	52-56
18381433-11	2008	Moreover, overexpression of Mst1 sensitizes prostate cancer cells to cisplatin treatment.	Cisplatin	69-78	macrophage stimulating 1	Homo sapiens	28-32
18328708-3	2008	RESULTS: We show that MST1 and MST2 activity increases during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit both an increase in both abundance and activation.	Nocodazole	85-95	macrophage stimulating 1	Homo sapiens	22-26
18328708-4	2008	MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2.	Okadaic Acid	58-70	macrophage stimulating 1	Homo sapiens	0-4
18328708-4	2008	MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2.	Hydrogen Peroxide	74-78	macrophage stimulating 1	Homo sapiens	0-4
17726016-10	2007	The phosphorylation mimetic mutant MST1 T387E blocks H2O2-triggered FOXO3 nuclear translocation and apoptosis.	Hydrogen Peroxide	53-57	macrophage stimulating 1	Homo sapiens	35-39
17395874-5	2007	After 4 weeks, Mst1 was significantly activated in the remodeling area in NTg, but not in Tg-DN-Mst1.	Nitroglycerin	74-77	macrophage stimulating 1	Homo sapiens	15-19
17637252-6	2007	RESULTS: MSP inhibited the proliferation of CFU-GM and CFU-GEMM in semi-solid culture and the inhibitory effect on CFU-GEMM was stronger than on CFU-GM.	cfu-gemm	55-63	macrophage stimulating 1	Homo sapiens	9-12
17637252-6	2007	RESULTS: MSP inhibited the proliferation of CFU-GM and CFU-GEMM in semi-solid culture and the inhibitory effect on CFU-GEMM was stronger than on CFU-GM.	cfu-gemm	115-123	macrophage stimulating 1	Homo sapiens	9-12
17538946-8	2007	Methylation status of MST1 was confirmed by bisulfite sequencing.	hydrogen sulfite	44-53	macrophage stimulating 1	Homo sapiens	22-26
17372272-8	2007	Additionally, we describe that the phosphorylation of AKT and eIF4G, as well as the elevation of the Mst1 and RanBP2 protein levels, can be inhibited in vivo in transgenic animals by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	macrophage stimulating 1	Homo sapiens	101-105
16633352-2	2006	We previously demonstrated that human macrophages of different origin express the tyrosine kinase receptor recepteur d"origine nantaise, the human receptor for MSP (RON) and produce superoxide anion (O(2)(-)) when challenged with macrophage-stimulating protein (MSP), the endogenous ligand for RON.	Superoxides	182-198	macrophage stimulating 1	Homo sapiens	160-163
16778179-6	2006	We also found that mammalian sterile20-like kinase 1 (MST1) was activated by bortezomib in K-ras-transformed cells and K-ras-mutated cancer cells.	Bortezomib	77-87	macrophage stimulating 1	Homo sapiens	54-58
16778179-7	2006	Treatment of K-ras-transformed cells with bortezomib resulted in translocation of MST1 from cytoplasm into the nucleus and an increase of phosphorylated histone H2B and histone H2AX.	Bortezomib	42-52	macrophage stimulating 1	Homo sapiens	82-86
16778179-8	2006	Moreover, pretreatment with leptomycin B, an inhibitor of the nuclear export signal receptor, dramatically enhanced bortezomib-mediated MST1 activation, phosphorylation of histones H2B and H2AX, and apoptosis induction in K-ras-transformed cells.	leptomycin B	28-40	macrophage stimulating 1	Homo sapiens	136-140
16778179-8	2006	Moreover, pretreatment with leptomycin B, an inhibitor of the nuclear export signal receptor, dramatically enhanced bortezomib-mediated MST1 activation, phosphorylation of histones H2B and H2AX, and apoptosis induction in K-ras-transformed cells.	Bortezomib	116-126	macrophage stimulating 1	Homo sapiens	136-140
16778179-9	2006	Knockdown of MST1 expression by small interfering RNA diminished bortezomib-induced apoptosis or caspase-3 activation.	Bortezomib	65-75	macrophage stimulating 1	Homo sapiens	13-17
16778179-10	2006	Our data suggested that bortezomib may be useful for treatment of K-ras-mutated cancer cells, and MST1 is one of the mediators for bortezomib-induced apoptosis in K-ras-transformed cells.	Bortezomib	131-141	macrophage stimulating 1	Homo sapiens	98-102
16633352-4	2006	MSP effects were compared with those induced by known AM stimuli, for example, phorbol myristate acetate, N-formyl-methionyl-leucyl-phenylalanine, lipopolysaccharide.MSP evokes O(2)(-) production, cytokine release and NF-kappaB activation in a concentration-dependent manner.	Superoxides	177-184	macrophage stimulating 1	Homo sapiens	166-169
16633352-5	2006	By evaluating the respiratory burst, we demonstrate a significantly increased O(2)(-) production in AM from healthy smokers or smokers with pulmonary fibrosis, as compared to non-smokers, thus suggesting MSP as an enhancer of cigarette smoke toxicity.	Superoxides	78-82	macrophage stimulating 1	Homo sapiens	204-207
16633352-2	2006	We previously demonstrated that human macrophages of different origin express the tyrosine kinase receptor recepteur d"origine nantaise, the human receptor for MSP (RON) and produce superoxide anion (O(2)(-)) when challenged with macrophage-stimulating protein (MSP), the endogenous ligand for RON.	Superoxides	200-204	macrophage stimulating 1	Homo sapiens	160-163
16633352-2	2006	We previously demonstrated that human macrophages of different origin express the tyrosine kinase receptor recepteur d"origine nantaise, the human receptor for MSP (RON) and produce superoxide anion (O(2)(-)) when challenged with macrophage-stimulating protein (MSP), the endogenous ligand for RON.	Superoxides	200-204	macrophage stimulating 1	Homo sapiens	230-260
16633352-2	2006	We previously demonstrated that human macrophages of different origin express the tyrosine kinase receptor recepteur d"origine nantaise, the human receptor for MSP (RON) and produce superoxide anion (O(2)(-)) when challenged with macrophage-stimulating protein (MSP), the endogenous ligand for RON.	Superoxides	200-204	macrophage stimulating 1	Homo sapiens	262-265
16633352-4	2006	MSP effects were compared with those induced by known AM stimuli, for example, phorbol myristate acetate, N-formyl-methionyl-leucyl-phenylalanine, lipopolysaccharide.MSP evokes O(2)(-) production, cytokine release and NF-kappaB activation in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	79-104	macrophage stimulating 1	Homo sapiens	166-169
14505491-1	2003	The tyrosine kinase Ron, receptor for MSP (macrophage-stimulating protein), displays several serine residues of unknown functions.	Serine	93-99	macrophage stimulating 1	Homo sapiens	38-41
15191539-4	2004	Immunohistology demonstrated expression of MSP receptor RON in the outer and inner root sheaths, hair matrix cells, DP, and bulbar DS whereas non-follicular epithelium and some cells of the sweat glands exhibited low-level receptor expression.	dp	116-118	macrophage stimulating 1	Homo sapiens	43-46
15191539-4	2004	Immunohistology demonstrated expression of MSP receptor RON in the outer and inner root sheaths, hair matrix cells, DP, and bulbar DS whereas non-follicular epithelium and some cells of the sweat glands exhibited low-level receptor expression.	ds	131-133	macrophage stimulating 1	Homo sapiens	43-46
16510573-6	2006	Moreover, the stimulatory effect of RASSF1A overexpression on Fas-induced apoptosis was inhibited by depletion of Mst1.	ammonium ferrous sulfate	62-65	macrophage stimulating 1	Homo sapiens	114-118
16170349-4	2006	Forced downregulation of MSP expression in H1299 cells, derived from a large-cell lung carcinoma, confers increased resistance against etoposide-induced cell death.	Etoposide	135-144	macrophage stimulating 1	Homo sapiens	25-28
14505491-4	2003	The association is stimulated by MSP or serum and is prevented by wortmannin, an inhibitor of the Akt/PKB (protein serine/threonine kinase B) pathway.	Wortmannin	66-76	macrophage stimulating 1	Homo sapiens	33-36
12802274-2	2003	Here we show that stimulation by MSP also recruits a negative regulator, the c-Cbl ubiquitin ligase, to the multifunctional docking site as well as to a juxtamembrane tyrosine autophosphorylation site.	Tyrosine	167-175	macrophage stimulating 1	Homo sapiens	33-36
12223493-14	2002	Together, these data suggest a model whereby MST1 activation is induced by existing, active MST kinase, which phosphorylates Thr(183) and possibly Thr(187).	Threonine	125-128	macrophage stimulating 1	Homo sapiens	45-49
12384512-8	2002	MST1 is predominantly cytoplasmic, but cycles continuously through the nucleus, as evidenced by its rapid accumulation in the nucleus after addition of the Crm1 inhibitor, leptomycin B.	leptomycin B	172-184	macrophage stimulating 1	Homo sapiens	0-4
12223493-14	2002	Together, these data suggest a model whereby MST1 activation is induced by existing, active MST kinase, which phosphorylates Thr(183) and possibly Thr(187).	Threonine	147-150	macrophage stimulating 1	Homo sapiens	45-49
11704649-0	2001	Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.	Superoxides	44-60	macrophage stimulating 1	Homo sapiens	0-30
11964314-7	2002	These studies therefore implicate a role for caspase- and H(2)O(2)-mediated cleavage of the Mst1 and the subsequent release of the 36-kd catalytic fragment in the mechanism of eosinophil apoptosis.	Hydrogen Peroxide	58-66	macrophage stimulating 1	Homo sapiens	92-96
11704649-0	2001	Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.	Superoxides	44-60	macrophage stimulating 1	Homo sapiens	32-35
11704649-6	2001	We show here that human recombinant MSP (hrMSP) evokes a dose-dependent superoxide anion production in human alveolar and peritoneal macrophages as well as in monocyte-derived macrophages, but not in circulating human monocytes.	Superoxides	72-88	macrophage stimulating 1	Homo sapiens	36-39
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Disulfides	124-133	macrophage stimulating 1	Homo sapiens	0-30
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Disulfides	124-133	macrophage stimulating 1	Homo sapiens	32-35
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Disulfides	124-133	macrophage stimulating 1	Homo sapiens	76-79
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Disulfides	124-133	macrophage stimulating 1	Homo sapiens	76-79
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Arginine	176-179	macrophage stimulating 1	Homo sapiens	0-30
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Arginine	176-179	macrophage stimulating 1	Homo sapiens	32-35
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Arginine	176-179	macrophage stimulating 1	Homo sapiens	76-79
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Arginine	176-179	macrophage stimulating 1	Homo sapiens	76-79
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Valine	185-188	macrophage stimulating 1	Homo sapiens	0-30
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Valine	185-188	macrophage stimulating 1	Homo sapiens	32-35
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Valine	185-188	macrophage stimulating 1	Homo sapiens	76-79
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Valine	185-188	macrophage stimulating 1	Homo sapiens	76-79
11332718-3	2001	MSP binding to RON causes receptor tyrosine phosphorylation leading to up-regulation of RON catalytic activity and subsequent activation of downstream signaling molecules.	Tyrosine	35-43	macrophage stimulating 1	Homo sapiens	0-3
11517310-5	2001	However, either truncation of the C-terminal domain, point mutation of the two putative NESs, or treatment with leptomycin B, an inhibitor of the NES receptor, results in nuclear localization of MST1.	leptomycin B	112-124	macrophage stimulating 1	Homo sapiens	195-199
11517310-6	2001	Staurosporine treatment induces chromatin condensation, MST1 cleavage, and nuclear translocation.	Staurosporine	0-13	macrophage stimulating 1	Homo sapiens	56-60
11517310-7	2001	Staurosporine-induced chromatin condensation is partially inhibited by expressing a kinase-negative mutant of MST1, suggesting an important role of MST1 in this process.	Staurosporine	0-13	macrophage stimulating 1	Homo sapiens	110-114
11517310-7	2001	Staurosporine-induced chromatin condensation is partially inhibited by expressing a kinase-negative mutant of MST1, suggesting an important role of MST1 in this process.	Staurosporine	0-13	macrophage stimulating 1	Homo sapiens	148-152
11278782-1	2001	The serine/threonine kinase Mst1, a mammalian homolog of the budding yeast Ste20 kinase, is cleaved by caspase-mediated proteolysis in response to apoptotic stimuli such as ligation of CD95/Fas or treatment with staurosporine.	Staurosporine	212-225	macrophage stimulating 1	Homo sapiens	28-32
11278782-7	2001	Autophosphorylation of Mst1 on a serine residue close to one of the caspase sites inhibited caspase-mediated cleavage in vitro.	Serine	33-39	macrophage stimulating 1	Homo sapiens	23-27