PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35128409-0	2022	Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation.	Sterols	49-55	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	25-32
7491113-5	1995	Similar to 3 beta HSD IV, 3 beta HSD V functions exclusively as a 3-ketosteroid reductase converting an active androgen, dihydrotestosterone (DHT), into an inactive androgen, 5 alpha-androstane-3 beta,17 beta-diol.	Dihydrotestosterone	121-140	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	66-89
7491113-5	1995	Similar to 3 beta HSD IV, 3 beta HSD V functions exclusively as a 3-ketosteroid reductase converting an active androgen, dihydrotestosterone (DHT), into an inactive androgen, 5 alpha-androstane-3 beta,17 beta-diol.	Dihydrotestosterone	142-145	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	66-89
7491113-5	1995	Similar to 3 beta HSD IV, 3 beta HSD V functions exclusively as a 3-ketosteroid reductase converting an active androgen, dihydrotestosterone (DHT), into an inactive androgen, 5 alpha-androstane-3 beta,17 beta-diol.	alpha-androstane-3 beta,17 beta-diol	177-213	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	66-89
35128409-7	2022	Mechanistically, the cellular accumulation of these 8,9-unsaturated sterols represents a central driver of enhanced oligodendrocyte formation, as exogenous addition of purified SC4MOL and HSD17B7 substrates but not their 8,9-saturated analogs promotes OPC differentiation.	8,9-unsaturated sterols	52-75	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	188-195
30227243-4	2019	Here we report the steady-state kinetics and binding study for 17beta-HSD7 with estrone or DHT as substrates and NADPH as cofactor.	Estrone	80-87	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	63-74
30227243-4	2019	Here we report the steady-state kinetics and binding study for 17beta-HSD7 with estrone or DHT as substrates and NADPH as cofactor.	Dihydrotestosterone	91-94	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	63-74
30227243-4	2019	Here we report the steady-state kinetics and binding study for 17beta-HSD7 with estrone or DHT as substrates and NADPH as cofactor.	NADP	113-118	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	63-74
27663891-8	2017	Among the genes related to estrogen metabolism, the level of 17beta-hydroxysteroid dehydrogenase 7 (HSD17B7) showed significant increase following CB126 exposure.	cb126	147-152	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	61-98
27663891-8	2017	Among the genes related to estrogen metabolism, the level of 17beta-hydroxysteroid dehydrogenase 7 (HSD17B7) showed significant increase following CB126 exposure.	cb126	147-152	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	100-107
27663891-9	2017	We further found that CB126 exposure decreased the methylation of the HSD17B7 promoter.	cb126	22-27	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	70-77
26018678-5	2015	Accordingly with the altered steroid production, altered expression of Star, Cyp11a1, Lhcgr, Hsd17b7, and especially Cyp17a1 was observed.	Steroids	29-36	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	93-100
26921468-1	2016	We previously reported a mutation in the cholesterol biosynthesis gene, hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7(rudolph)), that results in striking embryonic forebrain dysgenesis.	Cholesterol	41-52	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	72-112
26921468-1	2016	We previously reported a mutation in the cholesterol biosynthesis gene, hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7(rudolph)), that results in striking embryonic forebrain dysgenesis.	Cholesterol	41-52	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	114-121
26921468-6	2016	Combined administration of a statin and dietary cholesterol in utero achieved partial reversal of multiple developmental abnormalities in the Hsd17b7(rudolph) embryo, including the forebrain.	Cholesterol	48-59	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	142-149
26921468-7	2016	These results suggest that abnormally increased levels of specific cholesterol precursors in the Hsd17b7(rudolph) embryo cause cortical dysgenesis by altering patterns of neurogenesis.	Cholesterol	67-78	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	97-104
21912524-2	2011	Rudolph is an allele of the cholesterol biosynthetic enzyme, hydroxysteroid (17-beta) dehydrogenase 7, which is an intriguing finding given the recent implication of oxysterols in mediating intracellular Hedgehog (Hh) signaling.	Cholesterol	28-39	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	61-101
23022663-3	2013	In this study, an erg27 mutant containing the mouse ERG27 orthologue was isolated that was capable of growing without sterol supplementation (FGerg27).	Sterols	118-124	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	18-23
23022663-3	2013	In this study, an erg27 mutant containing the mouse ERG27 orthologue was isolated that was capable of growing without sterol supplementation (FGerg27).	Sterols	118-124	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	52-57
23022663-10	2013	Both FGerg27 and erg27 strains containing this fusion plasmid and the mouse ERG27 orthologue showed restoration of ergosterol biosynthesis with minimal accumulation of squalene epoxides.	Ergosterol	115-125	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	7-12
23022663-10	2013	Both FGerg27 and erg27 strains containing this fusion plasmid and the mouse ERG27 orthologue showed restoration of ergosterol biosynthesis with minimal accumulation of squalene epoxides.	Ergosterol	115-125	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	76-81
23022663-10	2013	Both FGerg27 and erg27 strains containing this fusion plasmid and the mouse ERG27 orthologue showed restoration of ergosterol biosynthesis with minimal accumulation of squalene epoxides.	oxidosqualene	168-185	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	76-81
23425349-8	2014	Only Sult1e1 and, surprisingly, Hsd17b7 expression was modulated with potentially opposite effects on oestradiol bioavailability.	Estradiol	102-112	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	32-39
21912524-2	2011	Rudolph is an allele of the cholesterol biosynthetic enzyme, hydroxysteroid (17-beta) dehydrogenase 7, which is an intriguing finding given the recent implication of oxysterols in mediating intracellular Hedgehog (Hh) signaling.	Oxysterols	166-176	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	61-101
17350061-8	2007	Several genes involved with steroid metabolism also showed remarkable expression changes, including increased expression of 17beta-hydroxysteroid dehydrogenase-7 (HSD17beta7; involved in estradiol production) and decreased expression of HSD17beta5 (involved in testosterone production).	Steroids	28-35	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	124-161
17350061-8	2007	Several genes involved with steroid metabolism also showed remarkable expression changes, including increased expression of 17beta-hydroxysteroid dehydrogenase-7 (HSD17beta7; involved in estradiol production) and decreased expression of HSD17beta5 (involved in testosterone production).	Estradiol	187-196	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	124-161
16356630-0	2006	Analysis of the 5" flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region.	Cholesterol	85-96	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	56-63
16356630-4	2006	The identified proximal promoter regions of both human and murine HSD17B7 genes contain multiple transcription factor binding sites and show strong similarity to cholesterogenic genes, especially to other postsqualene genes, but not to other steroidogenic genes.	postsqualene	205-217	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	66-73
16189819-2	2006	We have previously reported that the deficiency of 17beta-hydroxysteroid dehydrogenase type7 (Hsd17b7) is responsible for the cholesterol auxotrophy of NS0 cells.	Cholesterol	126-137	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	94-101
16189819-3	2006	Here we demonstrate DNA methylation to be the mechanism underlying transcriptional suppression of Hsd17b7 in cholesterol dependent NS0 cells.	Cholesterol	109-120	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	98-105
16189819-9	2006	These results affirm that deficiency of Hsd17b7 causes cholesterol dependence of NS0 cells.	Cholesterol	55-66	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	40-47
12829805-4	2003	Expression of human and murine HSD17B7 in an Erg27p-deficient yeast strain complements the 3-ketosteroid reductase deficiency of the cells and restores growth on sterol-deficient medium.	Sterols	162-168	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	31-38
12829805-4	2003	Expression of human and murine HSD17B7 in an Erg27p-deficient yeast strain complements the 3-ketosteroid reductase deficiency of the cells and restores growth on sterol-deficient medium.	Sterols	162-168	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	45-51
12829805-6	2003	Further critical evidence for a role of HSD17B7 in cholesterol metabolism is provided by the observation that its murine ortholog is a member of the same highly distinct embryonic synexpression group as hydroxymethyl-glutaryl-coenzyme A reductase, the rate-limiting enzyme of sterol biogenesis, and is specifically expressed in tissues that are involved in the pathogenesis of congenital cholesterol-deficiency disorders.	Cholesterol	51-62	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	40-47
12829805-6	2003	Further critical evidence for a role of HSD17B7 in cholesterol metabolism is provided by the observation that its murine ortholog is a member of the same highly distinct embryonic synexpression group as hydroxymethyl-glutaryl-coenzyme A reductase, the rate-limiting enzyme of sterol biogenesis, and is specifically expressed in tissues that are involved in the pathogenesis of congenital cholesterol-deficiency disorders.	Sterols	56-62	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	40-47
20185768-0	2010	Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos.	Cholesterol	80-91	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	0-39
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	Estrone	100-107	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	0-39
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	Estrone	100-107	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	41-48
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	Estradiol	111-120	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	0-39
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	Estradiol	111-120	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	41-48
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	Zymosterone	161-172	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	0-39
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	Zymosterone	161-172	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	41-48
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	zymosterol	176-186	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	0-39
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	zymosterol	176-186	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	41-48
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	Cholesterol	233-244	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	0-39
20185768-1	2010	Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro.	Cholesterol	233-244	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	41-48
20185768-3	2010	The data showed that the lack of HSD17B7 results in a blockage in the de novo cholesterol biosynthesis in mouse embryos in vivo, and HSD17BKO embryos die at embryonic day (E) 10.5.	Cholesterol	78-89	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	33-40
18991936-6	2008	Expression of genes related to steroid metabolism, such as 17beta-hydroxysteroid dehydrogenase-7 (HSD17beta7) and Cyp2a4, were increased approximately two-fold, together with increases in estrogen receptor-alpha (ER-alpha) and ER-alpha-linked genes, such as anterior gradient-2, keratin 1-19, and trefoil factor-3.	Steroids	31-38	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	59-96
18669642-2	2008	This enzyme, renamed HSD17B7 or PRAP/17beta-HSD7, converts estrone to estradiol and is also involved in cholesterol biosynthesis.	Estrone	59-66	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	21-28
18669642-2	2008	This enzyme, renamed HSD17B7 or PRAP/17beta-HSD7, converts estrone to estradiol and is also involved in cholesterol biosynthesis.	Estrone	59-66	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	37-48
18669642-2	2008	This enzyme, renamed HSD17B7 or PRAP/17beta-HSD7, converts estrone to estradiol and is also involved in cholesterol biosynthesis.	Estradiol	70-79	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	21-28
18669642-2	2008	This enzyme, renamed HSD17B7 or PRAP/17beta-HSD7, converts estrone to estradiol and is also involved in cholesterol biosynthesis.	Estradiol	70-79	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	37-48
18669642-2	2008	This enzyme, renamed HSD17B7 or PRAP/17beta-HSD7, converts estrone to estradiol and is also involved in cholesterol biosynthesis.	Cholesterol	104-115	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	21-28
18669642-2	2008	This enzyme, renamed HSD17B7 or PRAP/17beta-HSD7, converts estrone to estradiol and is also involved in cholesterol biosynthesis.	Cholesterol	104-115	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	37-48
16126295-0	2006	17Beta-hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells.	Cholesterol	61-72	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	44-51
16126295-4	2006	Hsd17b7 was previously shown to encode for an enzyme involved in estrogenic steroid biosynthesis.	Steroids	76-83	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	0-7
16126295-6	2006	To ascertain that its cholesterol biosynthesis is blocked at the reduction reaction catalyzed by Hsd17b7, we genetically engineered NS0 cells to over express Hsd17b7.	Cholesterol	22-33	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	158-165
16126295-7	2006	The stable transfectants of Hsd17b7 were able to grow independent of cholesterol.	Cholesterol	69-80	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	28-35
16126295-8	2006	The results affirm the role of Hsd17b7 in the cholesterol biosynthesis pathway in mammals.	Cholesterol	46-57	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	31-38