PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
7839095-5	1994	The increase in plasma secretin levels in response to duodenal acidification was reduced by stimulation and augmented by inhibition of duodenal mucosal bicarbonate secretion.	Bicarbonates	152-163	secretin	Sus scrofa	23-31
23243148-0	2013	Intracoronary secretin increases cardiac perfusion and function in anaesthetized pigs through pathways involving beta-adrenoceptors and nitric oxide.	Nitric Oxide	136-148	secretin	Sus scrofa	14-22
23243148-1	2013	Secretin has been implicated in cardiovascular regulation through its specific receptors, as well as through beta-adrenoceptors and nitric oxide, although data on its direct effect on coronary blood flow and cardiac function have remained scarce.	Nitric Oxide	132-144	secretin	Sus scrofa	0-8
9648629-1	1998	The importance of physiological plasma levels of secretin in biliary bicarbonate secretion is not known.	Bicarbonates	69-80	secretin	Sus scrofa	49-57
9648629-2	1998	However, in anaesthetized pigs the substantial hepatic output of bicarbonate into the duodenum in response to low doses of secretin exceeds pancreatic bicarbonate output.	Bicarbonates	65-76	secretin	Sus scrofa	123-131
9648629-3	1998	The aim was therefore to study the relationship between duodenal acidification, secretin and hepatic biliary bicarbonate output in the conscious pig.	Bicarbonates	109-120	secretin	Sus scrofa	80-88
9648629-5	1998	The biliary bicarbonate secretion in response to intraduodenal HCl, secretin or pentagastrin given intravenously, and to meal was studied.	Bicarbonates	12-23	secretin	Sus scrofa	68-76
9648629-6	1998	Intraduodenal HCl infusion, secretin and pentagastrin given intravenously augmented hepatic bicarbonate output and plasma secretin concentrations significantly.	Hydrochloric Acid	14-17	secretin	Sus scrofa	122-130
9648629-6	1998	Intraduodenal HCl infusion, secretin and pentagastrin given intravenously augmented hepatic bicarbonate output and plasma secretin concentrations significantly.	Pentagastrin	41-53	secretin	Sus scrofa	122-130
9648629-6	1998	Intraduodenal HCl infusion, secretin and pentagastrin given intravenously augmented hepatic bicarbonate output and plasma secretin concentrations significantly.	Bicarbonates	92-103	secretin	Sus scrofa	28-36
9648629-7	1998	The secretin response to acidification was sufficient to explain the subsequent increase in biliary bicarbonate secretion.	Bicarbonates	100-111	secretin	Sus scrofa	4-12
9648629-10	1998	The results demonstrate that hepatic bicarbonate secretion is stimulated by endogenous secretin and therefore may have a physiological role in duodenal neutralization.	Bicarbonates	37-48	secretin	Sus scrofa	87-95
7839095-6	1994	CONCLUSIONS: Duodenal mucosal bicarbonate secretion can serve as a modulator of both pancreatic and biliary bicarbonate secretion in response to luminal acidification, possibly through regulation of the release of secretin.	Bicarbonates	30-41	secretin	Sus scrofa	214-222
1947769-0	1991	Pancreatic, hepatic, and duodenal mucosal bicarbonate secretion during infusion of secretin and cholecystokinin.	Bicarbonates	42-53	secretin	Sus scrofa	83-91
8209176-0	1994	The effect of gastrin-releasing peptide on porcine pancreaticobiliary bicarbonate secretion is mediated by secretin.	Bicarbonates	70-81	secretin	Sus scrofa	107-115
8209176-3	1994	Blocking of CCK-A receptors by MK-329 did not significantly change the effect of GRP, whereas prevention of secretin release by removal of the small intestine caused a 13-fold reduction in the GRP-induced pancreatic bicarbonate secretion and completely abolished the effect on hepatic bicarbonate secretion but did not change the effect on pancreatic protein secretion.	Bicarbonates	216-227	secretin	Sus scrofa	108-116
8209176-3	1994	Blocking of CCK-A receptors by MK-329 did not significantly change the effect of GRP, whereas prevention of secretin release by removal of the small intestine caused a 13-fold reduction in the GRP-induced pancreatic bicarbonate secretion and completely abolished the effect on hepatic bicarbonate secretion but did not change the effect on pancreatic protein secretion.	Bicarbonates	285-296	secretin	Sus scrofa	108-116
1947769-5	1991	During infusion of secretin in doses that caused physiologic increases in plasma secretin concentrations the liver produced significantly more bicarbonate than the pancreas.	Bicarbonates	143-154	secretin	Sus scrofa	19-27
1947769-5	1991	During infusion of secretin in doses that caused physiologic increases in plasma secretin concentrations the liver produced significantly more bicarbonate than the pancreas.	Bicarbonates	143-154	secretin	Sus scrofa	81-89
1947769-2	1991	The effect of infusion of secretin alone or in combination with cholecystokinin (CCK) on pancreatic, hepatic, and duodenal mucosal bicarbonate secretion was studied in anaesthetized pigs.	Bicarbonates	131-142	secretin	Sus scrofa	26-34
1947769-6	1991	A physiologic dose of CCK augmented the effect of secretin on both hepatic and pancreatic bicarbonate secretion, but the hepatic production of bicarbonate was still larger than the pancreatic production.	Bicarbonates	90-101	secretin	Sus scrofa	50-58
1904674-0	1991	Secretin dissipates red acridine orange fluorescence from pancreatic duct epithelium.	red acridine orange	20-39	secretin	Sus scrofa	0-8
1904674-6	1991	The red fluorescence was abolished by secretin, or following incubation with chloroquine or NH4Cl or the protonophores carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) or carbonyl cyanide m-chlorophenylhydrazone (CCCP), leaving uniform green fluorescence.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	171-175	secretin	Sus scrofa	38-46
1904674-6	1991	The red fluorescence was abolished by secretin, or following incubation with chloroquine or NH4Cl or the protonophores carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) or carbonyl cyanide m-chlorophenylhydrazone (CCCP), leaving uniform green fluorescence.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	180-220	secretin	Sus scrofa	38-46
1904674-6	1991	The red fluorescence was abolished by secretin, or following incubation with chloroquine or NH4Cl or the protonophores carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) or carbonyl cyanide m-chlorophenylhydrazone (CCCP), leaving uniform green fluorescence.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	222-226	secretin	Sus scrofa	38-46
1904674-7	1991	These findings suggest that pancreatic duct cells contain CO2-dependent acidic compartments which vanish during secretin stimulation and which may be cytoplasmic tubulovesicles.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	58-61	secretin	Sus scrofa	112-120
2395872-4	1990	Sequence analysis of the isolated secretin precursor revealed a 71-amino acid residue polypeptide that contained the sequence of secretin N terminally, followed by a Gly-Lys-Arg sequence and a C-terminal extension of 41-amino acid residues.	Glycine	166-169	secretin	Sus scrofa	34-42
2395872-4	1990	Sequence analysis of the isolated secretin precursor revealed a 71-amino acid residue polypeptide that contained the sequence of secretin N terminally, followed by a Gly-Lys-Arg sequence and a C-terminal extension of 41-amino acid residues.	Lysine	170-173	secretin	Sus scrofa	34-42
2395872-4	1990	Sequence analysis of the isolated secretin precursor revealed a 71-amino acid residue polypeptide that contained the sequence of secretin N terminally, followed by a Gly-Lys-Arg sequence and a C-terminal extension of 41-amino acid residues.	Arginine	174-177	secretin	Sus scrofa	34-42
2719704-2	1989	The sequence of the heptacosapeptide amide H-S-D-G-T-F-T-S-E-L-S-R-L-Q-D-S-A-R-L-Q-R-L-L-Q-G-L-V-NH2 shows that rat secretin has a glutamine residue in position 14 instead of arginine as in pig secretin.	heptacosapeptide	20-36	secretin	Sus scrofa	194-202
2719704-2	1989	The sequence of the heptacosapeptide amide H-S-D-G-T-F-T-S-E-L-S-R-L-Q-D-S-A-R-L-Q-R-L-L-Q-G-L-V-NH2 shows that rat secretin has a glutamine residue in position 14 instead of arginine as in pig secretin.	Amides	37-42	secretin	Sus scrofa	194-202
2719704-2	1989	The sequence of the heptacosapeptide amide H-S-D-G-T-F-T-S-E-L-S-R-L-Q-D-S-A-R-L-Q-R-L-L-Q-G-L-V-NH2 shows that rat secretin has a glutamine residue in position 14 instead of arginine as in pig secretin.	h-s-d-g-t-f-t-s-e-l-s-r-l-q-d-s-a	43-76	secretin	Sus scrofa	194-202
2719704-2	1989	The sequence of the heptacosapeptide amide H-S-D-G-T-F-T-S-E-L-S-R-L-Q-D-S-A-R-L-Q-R-L-L-Q-G-L-V-NH2 shows that rat secretin has a glutamine residue in position 14 instead of arginine as in pig secretin.	r-l-q-r-l-l-q-g-l-v	77-96	secretin	Sus scrofa	194-202
7126706-2	1982	Intraduodenal infusion of 0.1 N HCl produced dramatic elevation of the mean serum secretin level to 2,090 +/- 340 pg/ml.	Hydrochloric Acid	32-35	secretin	Sus scrofa	82-90
98389-1	1978	Immunoreactive secretin in hydrochloric acid extracts is relatively constant in the duodenum and proximal jejunum of pig and dog (3 microgram per g), but peaks in the distal duodenum of guinea pig (1 microgram per g), no secretin being detectable in the ileum of these species.	Hydrochloric Acid	27-44	secretin	Sus scrofa	15-23
6828648-6	1983	The presence of secretin in the small intestine was confirmed by intrajejunal HCl infusion.	Hydrochloric Acid	78-81	secretin	Sus scrofa	16-24
7320893-8	1981	The duodenum secreted secretin rapidly in response to hydrochloric acid, but did not respond to any other luminal stimuli, including lipids, proteins, carbohydrates and bile.	Hydrochloric Acid	54-71	secretin	Sus scrofa	22-30
696858-5	1978	Infusion of secretin at a concentration of 834 pmol/liter in the presence of glucose at 7.5 mmol/liter provoked a significant (P less than 0.01) short-lived increase in insulin secretion.	Glucose	77-84	secretin	Sus scrofa	12-20
866988-6	1977	On the basis of the flow rate of pancreatic juice and the pancreatic bicarbonate output, secretin during instillation of HC1 was estimated to be 0.3 clinical unit kg-1 h-1.	Bicarbonates	69-80	secretin	Sus scrofa	89-97
866988-6	1977	On the basis of the flow rate of pancreatic juice and the pancreatic bicarbonate output, secretin during instillation of HC1 was estimated to be 0.3 clinical unit kg-1 h-1.	HC1	121-124	secretin	Sus scrofa	89-97
1174815-4	1975	When acid was allowed to inter the duodenum by closing the gastric fistula, intravenous alcohol produced a secretin-like effect of increased pancreatic volume and bicarbonate secretion.	Alcohols	88-95	secretin	Sus scrofa	107-115
1174815-4	1975	When acid was allowed to inter the duodenum by closing the gastric fistula, intravenous alcohol produced a secretin-like effect of increased pancreatic volume and bicarbonate secretion.	Bicarbonates	163-174	secretin	Sus scrofa	107-115
1174815-7	1975	The subsequently sustained increase in volume and bicarbonate was possibly a secondary secretin-like response following absorption of alcohol.	Bicarbonates	50-61	secretin	Sus scrofa	87-95
1174815-7	1975	The subsequently sustained increase in volume and bicarbonate was possibly a secondary secretin-like response following absorption of alcohol.	Alcohols	134-141	secretin	Sus scrofa	87-95