PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 30850392-1 2019 UDP-glucuronosyltransferase (UGT) 2A1 is an important enzyme in the detoxification of polycyclic aromatic hydrocarbons found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 86-118 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 0-37 31001917-0 2019 Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women. Vitamin D 14-23 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 70-78 30850392-9 2019 In H146 cells transfected with miRNA mimic together with a small interfering RNA (siRNA) specific for the UGT2A1 splice variant, a significant reduction in 3-hydroxy-benzo[a]pyrene-glucuronide formation was observed. 3-hydroxy-benzo[a 156-173 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 106-112 30850392-9 2019 In H146 cells transfected with miRNA mimic together with a small interfering RNA (siRNA) specific for the UGT2A1 splice variant, a significant reduction in 3-hydroxy-benzo[a]pyrene-glucuronide formation was observed. pyrene-glucuronide 174-192 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 106-112 25547628-9 2015 In contrast to the latter two UGTs that display significant specificity in the glucuronidation of BPS and BPF, UGT2A1 that is mainly expressed in the airways, exhibited high activity toward all the tested bisphenols, BPS, BPF and BPA. bis(4-hydroxyphenyl)sulfone 205-215 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 111-117 29635252-10 2018 CONCLUSIONS: Our findings suggest that PEAR1, P2Y12, and UGT2A1 genetic variants may be potential biomarkers that can be used to guide clinical applications of clopidogrel and aspirin in Chinese patients. Clopidogrel 160-171 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 57-63 29635252-10 2018 CONCLUSIONS: Our findings suggest that PEAR1, P2Y12, and UGT2A1 genetic variants may be potential biomarkers that can be used to guide clinical applications of clopidogrel and aspirin in Chinese patients. Aspirin 176-183 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 57-63 25547628-9 2015 In contrast to the latter two UGTs that display significant specificity in the glucuronidation of BPS and BPF, UGT2A1 that is mainly expressed in the airways, exhibited high activity toward all the tested bisphenols, BPS, BPF and BPA. bisphenol F 106-109 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 111-117 25547628-9 2015 In contrast to the latter two UGTs that display significant specificity in the glucuronidation of BPS and BPF, UGT2A1 that is mainly expressed in the airways, exhibited high activity toward all the tested bisphenols, BPS, BPF and BPA. bisphenol A 230-233 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 111-117 21164388-6 2011 Cell homogenates prepared from wildtype UGT2A1(75Lys308Gly) overexpressing HEK293 cells showed significant glucuronidation activity against a variety of polycyclic aromatic hydrocarbons including, 1-hydroxy-benzo(a)pyrene, benzo(a)pyrene-7,8-diol, and 5-methylchrysene-1,2-diol. 75lys308gly 47-58 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 40-46 23756265-0 2013 The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation. Bile Acids and Salts 85-94 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 38-44 23756265-3 2013 The present study characterized the BA-conjugating activity of the little-studied human UGTs of subfamily 2A: UGT2A1, 2A2, and 2A3. Bile Acids and Salts 36-38 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 110-116 23756265-6 2013 UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G. Lithocholic Acid 39-42 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 0-6 23756265-6 2013 UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G. Chenodeoxycholic Acid 58-62 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 0-6 23756265-6 2013 UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G. Deoxycholic Acid 59-62 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 0-6 23756265-6 2013 UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G. muricholic acid 75-78 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 0-6 23756265-6 2013 UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G. Chenodeoxycholic Acid 154-158 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 0-6 23756265-6 2013 UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G. Lithocholic Acid 49-52 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 0-6 23756265-6 2013 UGT2A1 was highly efficient in forming LCA-3 and LCA-24G, CDCA-24, DCA-24, HCA-24, and HDCA-24G, whereas UGT2A2 was the most active enzyme for CA-24G and CDCA-24G formation and also was able to generate HDCA-6G, HDCA-24G, LCA-24G, and HCA-24G. muricholic acid 235-238 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 0-6 23756265-9 2013 We demonstrate the high reactivity of the human UGT2A1 and UGT2A2 for bile acid glucuronidation. Bile Acids and Salts 70-79 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 48-54 21899827-6 2011 Nevertheless, the glucuronidation of ent-etiocholanolone and ent-androsterone by both UGT2B7 and UGT2B17 differs considerably from their respective activity toward the corresponding endogenous androgens, whereas UGT2A1-catalyzed conjugation is much less affected by the stereochemistry differences. ent-Etiocholanolone 37-56 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 212-218 21899827-6 2011 Nevertheless, the glucuronidation of ent-etiocholanolone and ent-androsterone by both UGT2B7 and UGT2B17 differs considerably from their respective activity toward the corresponding endogenous androgens, whereas UGT2A1-catalyzed conjugation is much less affected by the stereochemistry differences. ent-androsterone 61-77 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 212-218 21164388-6 2011 Cell homogenates prepared from wildtype UGT2A1(75Lys308Gly) overexpressing HEK293 cells showed significant glucuronidation activity against a variety of polycyclic aromatic hydrocarbons including, 1-hydroxy-benzo(a)pyrene, benzo(a)pyrene-7,8-diol, and 5-methylchrysene-1,2-diol. Polycyclic Aromatic Hydrocarbons 153-185 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 40-46 21164388-6 2011 Cell homogenates prepared from wildtype UGT2A1(75Lys308Gly) overexpressing HEK293 cells showed significant glucuronidation activity against a variety of polycyclic aromatic hydrocarbons including, 1-hydroxy-benzo(a)pyrene, benzo(a)pyrene-7,8-diol, and 5-methylchrysene-1,2-diol. 1-hydroxybenzo(a)pyrene 197-221 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 40-46 21164388-6 2011 Cell homogenates prepared from wildtype UGT2A1(75Lys308Gly) overexpressing HEK293 cells showed significant glucuronidation activity against a variety of polycyclic aromatic hydrocarbons including, 1-hydroxy-benzo(a)pyrene, benzo(a)pyrene-7,8-diol, and 5-methylchrysene-1,2-diol. benzo(a)pyrene 7,8-dihydrodiol 223-246 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 40-46 21164388-6 2011 Cell homogenates prepared from wildtype UGT2A1(75Lys308Gly) overexpressing HEK293 cells showed significant glucuronidation activity against a variety of polycyclic aromatic hydrocarbons including, 1-hydroxy-benzo(a)pyrene, benzo(a)pyrene-7,8-diol, and 5-methylchrysene-1,2-diol. 5-methylchrysene-1,2-diol 252-277 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 40-46 19661211-9 2009 An exception was the glucuronidation of etiocholanolone by UGT2A1 that revealed a very low substrate affinity in combination with very high V(max) value. Etiocholanolone 40-55 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 59-65 19022937-10 2009 Although UGT2B7 and UGT2B17 exhibited high, although converse, stereoselectivity in testosterone and epitestosterone glucuronidation, UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzed the glucuronidation of both steroids at considerable rates and similar kinetics. Epitestosterone 101-116 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 134-140 19022937-0 2009 UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. Testosterone 84-96 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 142-148 19022937-10 2009 Although UGT2B7 and UGT2B17 exhibited high, although converse, stereoselectivity in testosterone and epitestosterone glucuronidation, UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzed the glucuronidation of both steroids at considerable rates and similar kinetics. Steroids 253-261 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 134-140 35625946-7 2022 Among prognostic polymorphisms, we found a potential role of UGT2A1 both as a predictor of platinum-response (p = 0.01) and as prognostic of survival (p = 0.05). Platinum 91-99 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 61-67