PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25036388-3	2014	In the model plant Arabidopsis, MORE AXILLARY GROWTH1 (MAX1), MAX2, MAX3 and MAX4 are four founding members of strigolactone pathway genes.	GR24 strigolactone	111-124	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	68-72
31245785-8	2019	Our results show that the tbl29-associated irx phenotypes are dependent on the MAX3 and MAX4 enzymes, involved in the early steps of SL biosynthesis.	Ser-Leu	133-135	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	79-83
29341173-6	2018	Unlike the wild type plants, chilling-induced inhibition of photosynthetic carbon assimilation was observed in the rms lines and also in the Arabidopsis max3-9, max4-1, and max2-1 mutants that are defective in SL synthesis or signalling.	Carbon	75-81	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	153-159
34961192-4	2021	The expression level of two SL biosynthetic genes, MOREAXILLARY GROWTH 3 and 4 (MAX3 and MAX4), which are responsible for the conversion of carotene to carotenal, increased during the induction phase of embryogenesis.	Carotenoids	140-148	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	80-84
34961192-4	2021	The expression level of two SL biosynthetic genes, MOREAXILLARY GROWTH 3 and 4 (MAX3 and MAX4), which are responsible for the conversion of carotene to carotenal, increased during the induction phase of embryogenesis.	carotenal	152-161	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	80-84
34961192-5	2021	Arabidopsis mutant studies indicated that the somatic embryo number was inhibited in max3 and max4 mutants, and this effect was reversed by applications of GR24, a synthetic strigolactone, and exacerbated by TIS108, a SL biosynthetic inhibitor.	GR24	156-160	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	85-89
34961192-5	2021	Arabidopsis mutant studies indicated that the somatic embryo number was inhibited in max3 and max4 mutants, and this effect was reversed by applications of GR24, a synthetic strigolactone, and exacerbated by TIS108, a SL biosynthetic inhibitor.	GR24 strigolactone	174-187	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	85-89
34292662-4	2021	An analysis of the promoters of five of the differentially expressed genes (FWA, ACC1, TFL1, MAX3, and GRP3) pointed to an inverse relationship between cytosine methylation and transcription.	Cytosine	152-160	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	93-97
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	GR24 strigolactone	17-30	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	51-57
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	GR24 strigolactone	17-30	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	229-235
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	9-cis-configured acyclic carotenes	68-102	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	51-57
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	9-cis-configured acyclic carotenes	68-102	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	229-235
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	9-cis-zeta-carotene	112-131	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	51-57
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	9-cis-zeta-carotene	112-131	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	229-235
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	9'-cis-neurosporene	133-152	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	51-57
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	9'-cis-neurosporene	133-152	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	229-235
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	9-cis-Lycopene	158-172	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	51-57
27811075-6	2016	In contrast, the strigolactone biosynthetic enzyme AtCCD7 converted 9-cis-configured acyclic carotenes, such as 9-cis-zeta-carotene, 9"-cis-neurosporene, and 9-cis-lycopene, yielding 9-cis-configured products and indicating that AtCCD7, rather than AtCCD4, is the candidate for forming acyclic retrograde signals.	9-cis-Lycopene	158-172	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	229-235
26945857-4	2016	Strigolactones (SLs) are synthesized from all-trans-beta-carotene via a pathway involving the beta-carotene isomerase DWARF27, the carotenoid cleavage dioxygenases 7 and 8 (CCD7, CCD8), and cytochrome P450 enzymes from the 711 clade (MAX1 in Arabidopsis).	strigolactones	0-14	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	173-177
26945857-4	2016	Strigolactones (SLs) are synthesized from all-trans-beta-carotene via a pathway involving the beta-carotene isomerase DWARF27, the carotenoid cleavage dioxygenases 7 and 8 (CCD7, CCD8), and cytochrome P450 enzymes from the 711 clade (MAX1 in Arabidopsis).	Sodium dodecyl sulfate	16-19	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	173-177
26653175-6	2016	Nitrogen deficient conditions led to alterations in the expression levels of SL biosynthesis genes (MAX3 and MAX4).	Nitrogen	0-8	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	100-104
26257333-1	2015	The first three enzymatic steps of the strigolactone biosynthetic pathway catalysed by beta-carotene cis-trans isomerase Dwarf27 (D27) from Oryza sativa and carotenoid cleavage dioxygenases CCD7 and CCD8 from Arabidopsis thaliana have been reconstituted in vitro, and kinetic assays have been developed for each enzyme, in order to develop selective enzyme inhibitors.	GR24 strigolactone	39-52	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	190-194
24685691-1	2014	Strigolactones are phytohormones synthesized from carotenoids via a stereospecific pathway involving the carotenoid cleavage dioxygenases 7 (CCD7) and 8.	strigolactones	0-14	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	141-145
24685691-1	2014	Strigolactones are phytohormones synthesized from carotenoids via a stereospecific pathway involving the carotenoid cleavage dioxygenases 7 (CCD7) and 8.	Carotenoids	50-61	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	141-145
24685691-2	2014	CCD7 cleaves 9-cis-beta-carotene to form a supposedly 9-cis-configured beta-apo-10"-carotenal.	9-cis-beta-carotene	13-32	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	0-4
24685691-2	2014	CCD7 cleaves 9-cis-beta-carotene to form a supposedly 9-cis-configured beta-apo-10"-carotenal.	9-cis-configured beta-apo-10"-carotenal	54-93	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	0-4
16021500-9	2005	Sequencing the target DNA region and comparing the counterpart DNA sequences between the htd-1 mutant and other rice varieties revealed a nucleotide substitution corresponding to an amino acid substitution from prolin to leucine in a predicted rice gene, OsCCD7, the rice orthologous gene of AtMAX3/CCD7.	DL-Proline	211-217	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	292-298
24198318-11	2014	Interestingly, ABA, osmotic stress, and drought-sensitive phenotypes were restricted to max2, and the strigolactone biosynthetic pathway mutants max1, max3, and max4 did not display any defects in these responses.	GR24 strigolactone	102-115	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	151-155
22702898-9	2012	Presence of an EF hand domain, a characteristic feature of calcium binding proteins and a role in the synthesis of retinol which is transported by retinol binding protein, a protein found in kidney stone matrix; of CCD7 support the role of TTP as an antilithiatic protein.	Vitamin A	115-122	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	215-219
22414435-10	2012	Furthermore, both wild-type and strigolactone biosynthesis mutants of Arabidopsis thaliana Atccd7 and Atccd8 induced similar levels of P. ramosa seed germination, suggesting that compounds other than strigolactone function as germination stimulants for P. ramosa in other Brassicaceae spp.	GR24 strigolactone	32-45	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	91-97
22414435-10	2012	Furthermore, both wild-type and strigolactone biosynthesis mutants of Arabidopsis thaliana Atccd7 and Atccd8 induced similar levels of P. ramosa seed germination, suggesting that compounds other than strigolactone function as germination stimulants for P. ramosa in other Brassicaceae spp.	GR24 strigolactone	200-213	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	91-97
17092317-4	2006	The rescue of the Arabidopsis max3 mutant phenotype by the introduction of Pro(35S):HTD1 indicates HTD1 is a carotenoid cleavage dioxygenase that has the same function as MAX3 in synthesis of a carotenoid-derived signal molecule.	Sulfur-35	79-82	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	30-34
17092317-4	2006	The rescue of the Arabidopsis max3 mutant phenotype by the introduction of Pro(35S):HTD1 indicates HTD1 is a carotenoid cleavage dioxygenase that has the same function as MAX3 in synthesis of a carotenoid-derived signal molecule.	Carotenoids	109-119	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	30-34
17092317-4	2006	The rescue of the Arabidopsis max3 mutant phenotype by the introduction of Pro(35S):HTD1 indicates HTD1 is a carotenoid cleavage dioxygenase that has the same function as MAX3 in synthesis of a carotenoid-derived signal molecule.	Carotenoids	109-119	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	171-175
16021500-9	2005	Sequencing the target DNA region and comparing the counterpart DNA sequences between the htd-1 mutant and other rice varieties revealed a nucleotide substitution corresponding to an amino acid substitution from prolin to leucine in a predicted rice gene, OsCCD7, the rice orthologous gene of AtMAX3/CCD7.	Leucine	221-228	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	292-298
15342640-10	2004	To determine the biochemical function of AtCCD7, the protein was expressed in carotenoid-accumulating strains of Escherichia coli.	Carotenoids	78-88	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	41-47
15342640-13	2004	When AtCCD7 and AtCCD8 were co-expressed in a beta-carotene-producing strain of E. coli, the 13-apo-beta-carotenone (C18) was produced.	beta-apo-13-carotenone	93-115	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	5-11
15342640-11	2004	The activity of AtCCD7 was also tested in vitro with several of the most common plant carotenoids.	Carotenoids	86-97	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	16-22
15342640-12	2004	It was shown that the recombinant AtCCD7 protein catalyzes a specific 9-10 cleavage of beta-carotene to produce the 10 black triangle down-apo-beta-carotenal (C27) and beta-ionone (C13).	beta Carotene	87-100	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	34-40
15342640-13	2004	When AtCCD7 and AtCCD8 were co-expressed in a beta-carotene-producing strain of E. coli, the 13-apo-beta-carotenone (C18) was produced.	1-octadecene	117-120	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	5-11
15342640-12	2004	It was shown that the recombinant AtCCD7 protein catalyzes a specific 9-10 cleavage of beta-carotene to produce the 10 black triangle down-apo-beta-carotenal (C27) and beta-ionone (C13).	beta-carotenal	143-157	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	34-40
15342640-15	2004	The sequential cleavages of beta-carotene by AtCCD7 and AtCCD8 are likely the initial steps in the synthesis of a carotenoid-derived signaling molecule that is necessary for the regulation lateral branching.	beta Carotene	28-41	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	45-51
15342640-15	2004	The sequential cleavages of beta-carotene by AtCCD7 and AtCCD8 are likely the initial steps in the synthesis of a carotenoid-derived signaling molecule that is necessary for the regulation lateral branching.	Carotenoids	114-124	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	45-51
15342640-12	2004	It was shown that the recombinant AtCCD7 protein catalyzes a specific 9-10 cleavage of beta-carotene to produce the 10 black triangle down-apo-beta-carotenal (C27) and beta-ionone (C13).	beta-ionone	168-179	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	34-40
15342640-13	2004	When AtCCD7 and AtCCD8 were co-expressed in a beta-carotene-producing strain of E. coli, the 13-apo-beta-carotenone (C18) was produced.	beta Carotene	46-59	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	5-11
15268852-5	2004	Consistent with its proposed function in the synthesis of a novel signaling molecule, we show that MAX3 encodes a plastidic dioxygenase that can cleave multiple carotenoids.	Carotenoids	161-172	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	99-103
15268852-6	2004	CONCLUSIONS: We conclude that MAX3 is required for the synthesis of a novel carotenoid-derived long-range signal that regulates shoot branching.	Carotenoids	76-86	carotenoid cleavage dioxygenase 7	Arabidopsis thaliana	30-34