PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 12105418-4 2002 Our genetic and molecular analyses argue that during gastrulation, trilobite interacts with the PCP pathway without affecting canonical Wnt signalling. pcp 96-99 VANGL planar cell polarity protein 2 Danio rerio 67-76 24164477-12 2014 Notable among these was that vangl2, involved in convergent extension movements of the embryonic axis, interacted strongly with EtOH. Ethanol 128-132 VANGL planar cell polarity protein 2 Danio rerio 29-35 24021482-13 2013 Together, our results demonstrate that zebrafish Vangl2/Prickle1a and non-canonical Wnt/Frizzled signaling have opposing effects on ECM organization underlying PCP and gastrulation cell movements. pcp 160-163 VANGL planar cell polarity protein 2 Danio rerio 49-55 17239849-4 2007 In zebrafish, simultaneous inactivation of non-canonical Wnt signaling components Knypek and Trilobite strongly impairs C&E gastrulation movements. c& 120-125 VANGL planar cell polarity protein 2 Danio rerio 93-102 17239849-5 2007 Here we show that knypek;trilobite double mutants exhibit a severe deficit in slow muscles and their precursor, adaxial cells, revealing essential roles of C&E movements in adaxial cell development. c& 156-161 VANGL planar cell polarity protein 2 Danio rerio 25-34 17239849-9 2007 We provide direct evidence to show that the deficiency of adaxial cells in knypek;trilobite double mutants is due to impaired C&E movements, rather than an alteration in Hedgehog signal and its reception, or a cell-autonomous requirement for Knypek and Trilobite in adaxial cell development. Adenosine Monophosphate 128-131 VANGL planar cell polarity protein 2 Danio rerio 82-91 34210294-13 2021 By characterizing membrane protrusions, we demonstrate that ethanol synergistically interacts with the loss of vangl2 to disrupt cell polarity required for convergent extension movements. Ethanol 60-67 VANGL planar cell polarity protein 2 Danio rerio 111-117 34210294-6 2021 RESULTS: We first show that vangl2, a member of the Wnt/planar cell polarity (Wnt/PCP) pathway that mediates convergent extension movements, strongly interacts with ethanol during late blastula and early gastrula stages. Ethanol 165-172 VANGL planar cell polarity protein 2 Danio rerio 28-34 34210294-7 2021 Embryos mutant or heterozygous for vangl2 are sensitized to ethanol-induced midfacial hypoplasia. Ethanol 60-67 VANGL planar cell polarity protein 2 Danio rerio 35-41 34210294-8 2021 We performed single-embryo RNA-seq during early embryonic stages to assess individual variation in the transcriptional response to ethanol and determine the mechanism of the vangl2-ethanol interaction. Ethanol 181-188 VANGL planar cell polarity protein 2 Danio rerio 174-180 34210294-14 2021 CONCLUSIONS: Our results show that the midfacial defects in ethanol-exposed vangl2 mutants are likely due to an indirect interaction between ethanol and the Shh pathway. Ethanol 60-67 VANGL planar cell polarity protein 2 Danio rerio 76-82 34210294-14 2021 CONCLUSIONS: Our results show that the midfacial defects in ethanol-exposed vangl2 mutants are likely due to an indirect interaction between ethanol and the Shh pathway. Ethanol 141-148 VANGL planar cell polarity protein 2 Danio rerio 76-82 29772239-9 2018 Interestingly, the interaction between R-Ras and Vangl2 was stronger in guanine-nucleotide free point mutants of R-Ras than in wild-type or constitutively active (GTP-bound) forms of R-Ras. Guanine Nucleotides 72-90 VANGL planar cell polarity protein 2 Danio rerio 49-55 31029691-8 2019 Nocodazole-induced loss of MT polymerization disrupts basal body positioning as well as GFP-Vangl2 localization and reduces cytosolic Fzd3a-GFP movements. Nocodazole 0-10 VANGL planar cell polarity protein 2 Danio rerio 92-98 29772239-9 2018 Interestingly, the interaction between R-Ras and Vangl2 was stronger in guanine-nucleotide free point mutants of R-Ras than in wild-type or constitutively active (GTP-bound) forms of R-Ras. Guanosine Triphosphate 163-166 VANGL planar cell polarity protein 2 Danio rerio 49-55