PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
10522785-4	1999	Both the magnitude and duration of the specific IgM responses in these calves were increased by pre-treatment with PGA.	Folic Acid	115-118	IgM	Bos taurus	48-51
11684295-4	2001	The C1q-binding site, involved in classical complement pathway, is identified in bovine IgM where ten amino acids are conserved across species.	C10Ph	4-7	IgM	Bos taurus	88-91
11684295-5	2001	Interestingly, bovine IgM has the lowest number of proline residues (5) in the Cmu2 domain in comparison to other species (7-9) and this is likely to impose structural constraints on mobility of Fab arms of the bovine IgM during antigen recognition.	Proline	51-58	IgM	Bos taurus	22-25
11684295-5	2001	Interestingly, bovine IgM has the lowest number of proline residues (5) in the Cmu2 domain in comparison to other species (7-9) and this is likely to impose structural constraints on mobility of Fab arms of the bovine IgM during antigen recognition.	Proline	51-58	IgM	Bos taurus	218-221
11684295-6	2001	The rigidity in the bovine IgM Cmu2 domain may, however, facilitate exposure of C1q-binding site subsequent to antigen binding and enhance its complement fixing ability.	C10Ph	80-83	IgM	Bos taurus	27-30
11684295-9	2001	Additional hydrophilic threonine and serine residues in the Cmu2 domain of bovine IgM, as compared to other species, however, enhance its ability to extend into the solvent.	Threonine	23-32	IgM	Bos taurus	82-85
11684295-9	2001	Additional hydrophilic threonine and serine residues in the Cmu2 domain of bovine IgM, as compared to other species, however, enhance its ability to extend into the solvent.	Serine	37-43	IgM	Bos taurus	82-85
10522785-5	1999	In addition, the fourth infected calf tested gave a single positive IgM result following PGA treatment.	Folic Acid	89-92	IgM	Bos taurus	68-71
10522785-6	1999	Transient or persistent IgM responses which were abolished by pre-treatment of sera with PGA were detected in 4/8 calves following reinfection.	Folic Acid	89-92	IgM	Bos taurus	24-27
10522785-8	1999	One of these calves and two additional calves showed transient increases in IgM which were resistant to PGA treatment.	Folic Acid	104-107	IgM	Bos taurus	76-79
9415031-1	1997	Mice infected with African trypanosomes produce exceptionally large amounts of serum IgM, a major part of which binds to non-trypanosome antigens such as trinitrophenol and single-strand DNA.	picric acid	154-168	IgM	Bos taurus	85-88
8408867-1	1993	Effects of trans and cis isomers of retinol and retinoic acid on IgM secretion by bovine peripheral blood mononuclear leukocytes were evaluated in vitro.	Vitamin A	36-43	IgM	Bos taurus	65-68
8792284-9	1996	Caprylic acid lowered non-specific binding of IgG1 and IgM in secretions during the dry period from unimmunized control cows and lowered IgM from immunized cows.	octanoic acid	0-13	IgM	Bos taurus	55-58
8792284-9	1996	Caprylic acid lowered non-specific binding of IgG1 and IgM in secretions during the dry period from unimmunized control cows and lowered IgM from immunized cows.	octanoic acid	0-13	IgM	Bos taurus	137-140
8525084-3	1995	The percentage of IgM-bearing cells was significantly higher in the BLV+PL+ group than in the BLV-PL- and BLV+PL- groups by FACS.	pl	72-74	IgM	Bos taurus	18-21
8408867-1	1993	Effects of trans and cis isomers of retinol and retinoic acid on IgM secretion by bovine peripheral blood mononuclear leukocytes were evaluated in vitro.	Tretinoin	48-61	IgM	Bos taurus	65-68
8408867-5	1993	However, each retinoid affected IgM secretion by cultures stimulated by mitogen.	Retinoids	14-22	IgM	Bos taurus	32-35
8408867-8	1993	Each retinoid enhanced IgM secretion at one or more concentrations, although enhancement was produced by much lower concentrations of retinoic acid isomers than retinol isomers.	Retinoids	5-13	IgM	Bos taurus	23-26
8408867-9	1993	These results indicate that retinol and retinoic acid modulate polyclonal IgM secretion by cultures of bovine mononuclear leukocytes stimulated by mitogen.	Vitamin A	28-35	IgM	Bos taurus	74-77
8408867-9	1993	These results indicate that retinol and retinoic acid modulate polyclonal IgM secretion by cultures of bovine mononuclear leukocytes stimulated by mitogen.	Tretinoin	40-53	IgM	Bos taurus	74-77
2714400-6	1989	The 80-kDa component, purified by velocity sedimentation in dodecyl sulfate, reacts with anti-rat IgM by immunoblot analyses.	dodecyl sulfate	60-75	IgM	Bos taurus	98-101
1689771-0	1990	Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons.	N-acetylgalactosaminuronic acid	39-45	IgM	Bos taurus	17-20
1689771-1	1990	An IgM monoclonal autoantibody (M-protein) with anti-Gal(beta 1-3)GalNAc activity from a patient with lower motor neuron disease bound to the surface of motoneurons isolated from bovine spinal cord.	cyclohexenoesculetin-beta-galactoside	53-56	IgM	Bos taurus	3-6
2714400-9	1989	These results indicate that the disulfide-linked, multi-meric 80-kDa component is bovine IgM, which binds strongly to a cell-surface component of the microvilli, and is indirectly associated with the microfilament cores.	Disulfides	32-41	IgM	Bos taurus	89-92
6351419-6	1983	Antibody raised early in the response was sensitive to treatment with 2-mercaptoethanol (2-ME) suggesting that IgM was the predominant class of immunoglobulin.	Mercaptoethanol	70-87	IgM	Bos taurus	111-114
6351419-6	1983	Antibody raised early in the response was sensitive to treatment with 2-mercaptoethanol (2-ME) suggesting that IgM was the predominant class of immunoglobulin.	Mercaptoethanol	89-93	IgM	Bos taurus	111-114
25079171-12	2014	Moreover, a negative correlation between IgM antibodies against L. corymbifera, L. ramosa, and Rhizopus relative to glyphosate concentration in urine was observed.	glyphosate	116-126	IgM	Bos taurus	41-44
23496254-2	2013	Further, this study included total natural antibody titers binding the antigens mentioned above, making no isotype distinction, as well as total natural antibody titers and natural antibody isotypes IgA, IgG1 and IgM binding lipoteichoic acid.	lipoteichoic acid	225-242	IgM	Bos taurus	213-216
3538954-9	1986	Concentrations of whey IgG1 and IgM in endotoxin-inoculated quarters were significantly (P less than 0.05) decreased in flunixin meglumine-treated cows, compared with those in saline solution-treated cows.	flunixin meglumine	120-138	IgM	Bos taurus	32-35
3111522-5	1986	IgM antibodies were isolated from serum by column chromatography on Sefadeks G-200 gel and IgG1 and IgG2 by column chromatography on DEAE cellulose.	DEAE-Cellulose	133-147	IgM	Bos taurus	0-3
4000701-4	1985	The addition of 0.08 M 2-mercaptoethanol inhibited IgM-mediated ADCC but not that of IgG1 or IgG2, and the cytotoxicity occurred in the absence of complement.	Mercaptoethanol	23-40	IgM	Bos taurus	51-54
749644-4	1978	In order to try and explain these discrepancies, we have compared the activity of different commercial preparations of the Rose Bengal antigen for purified IgG1, IgG2 OR Igm dies.	Rose Bengal	123-134	IgM	Bos taurus	170-173
810233-1	1975	Purified bovine colostral intact immunoglobulin M (IgM) exhibited the presence of an anodal, single, fast moving band (noncovalently bound form) when subjected to analytical polyacrylamide gel electrophoresis at an alkaline pH in urea.	polyacrylamide	174-188	IgM	Bos taurus	33-49
810233-1	1975	Purified bovine colostral intact immunoglobulin M (IgM) exhibited the presence of an anodal, single, fast moving band (noncovalently bound form) when subjected to analytical polyacrylamide gel electrophoresis at an alkaline pH in urea.	polyacrylamide	174-188	IgM	Bos taurus	51-54
810233-1	1975	Purified bovine colostral intact immunoglobulin M (IgM) exhibited the presence of an anodal, single, fast moving band (noncovalently bound form) when subjected to analytical polyacrylamide gel electrophoresis at an alkaline pH in urea.	Urea	230-234	IgM	Bos taurus	33-49
810233-1	1975	Purified bovine colostral intact immunoglobulin M (IgM) exhibited the presence of an anodal, single, fast moving band (noncovalently bound form) when subjected to analytical polyacrylamide gel electrophoresis at an alkaline pH in urea.	Urea	230-234	IgM	Bos taurus	51-54
810233-7	1975	The stoichiometry of J-chain, determined from the densitometric tracing of the reduced and alkylated bovine colostral IgM (devoid of the noncovalently bound J-chain) in stained analytical polyacrylamide gels, revealed the presence of one J-chain per IgM molecule.	polyacrylamide	188-202	IgM	Bos taurus	118-121
30449009-8	2019	The IgM MC was sig-d in G-B and C at 3 h PV (5 and 6 FI respectively), at 24 h PV (5 and 9 FI respectively), at week 3 PV(2 and 2 FI respectively) and week 4 PV (3 and 4 FI respectively).	Methylcholanthrene	8-10	IgM	Bos taurus	4-7
25682147-5	2015	Moderate positive phenotypic correlations were found between NAb levels in milk and in plasma: 0.18 for IgG and 0.40 for IgM.	nab	61-64	IgM	Bos taurus	121-124
25682147-7	2015	However, high genetic correlations were found for NAb in milk and plasma: 0.81 for IgG and 0.79 for IgM.	nab	50-53	IgM	Bos taurus	100-103
25682147-8	2015	Heritabilities (SE in parentheses) for NAb measured in plasma [0.15 (0.05) for IgG and 0.25 (0.06) for IgM] were higher than heritabilities of NAb measured in milk [0.08 (0.03) for IgG and 0.23 (0.05) for IgM].	nab	39-42	IgM	Bos taurus	103-106
24480068-1	2014	A sensitive and selective wavelength-modulation surface plasmon resonance (SPR) biosensor based on graphene oxide (GO) and Au bipyramids (AuBPs) is reported for determination of bovine IgM.	graphene oxide	99-113	IgM	Bos taurus	185-188
24480068-1	2014	A sensitive and selective wavelength-modulation surface plasmon resonance (SPR) biosensor based on graphene oxide (GO) and Au bipyramids (AuBPs) is reported for determination of bovine IgM.	graphene oxide	115-117	IgM	Bos taurus	185-188
24480068-1	2014	A sensitive and selective wavelength-modulation surface plasmon resonance (SPR) biosensor based on graphene oxide (GO) and Au bipyramids (AuBPs) is reported for determination of bovine IgM.	au bipyramids	123-136	IgM	Bos taurus	185-188
24480068-1	2014	A sensitive and selective wavelength-modulation surface plasmon resonance (SPR) biosensor based on graphene oxide (GO) and Au bipyramids (AuBPs) is reported for determination of bovine IgM.	aubps	138-143	IgM	Bos taurus	185-188
24480068-5	2014	In the optimal conditions, the GO-based biosensor with AuBPs as sensitivity enhancers shows a satisfactory response to bovine IgM in the concentration range of 0.03-32 mug mL(-1).	graphene oxide	31-33	IgM	Bos taurus	126-129
12807823-2	2003	These massive CDR3H segments will greatly influence the tertiary and quaternary structures of the bovine IgM combining sites.	cdr3h	14-19	IgM	Bos taurus	105-108
12807823-4	2003	There appears to be an exquisite selective pressure for the use of three V(lambda)1 genes (V(lambda)1x and two new V(lambda)1d and V(lambda)1e genes) in IgM with unusually long CDR3H.	cdr3h	177-182	IgM	Bos taurus	153-156