PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2573603-4	1989	In cells treated with the potassium ionophore, nonactin, both hsp 58 and grp 75 were observed to accumulate in precursor form.	Potassium	26-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	62-65
3312423-5	1987	In sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the purified HSP consisted of two proteins (70 and 62 kilodaltons [kd]), but only the 62-kd protein was detected in the 15,000 g supernatant fraction of the extract using the immunoblotting technique.	Sodium Dodecyl Sulfate	3-25	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-78
2605694-1	1989	A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized.	Serine	66-69	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
2605694-1	1989	A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized.	Leucine	50-53	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
2605694-1	1989	A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized.	Threonine	74-77	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
2605694-1	1989	A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized.	Alanine	30-33	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
2605694-1	1989	A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized.	Glutamic Acid	46-49	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
2605694-1	1989	A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized.	Histidine	86-89	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
2605694-1	1989	A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized.	Alanine	78-81	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
2605694-1	1989	A heptadecapeptide, H-Arg-Lys-Ala-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Glu-His-OH , corresponding to amino acids 32 to 48 of human splenin (hSP) and an analog in which the amino acid residue at position 34 is changed from Ala to Glu, were synthesized.	Glutamic Acid	82-85	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
2787213-1	1989	[Glu34]human splenin (hSP) was synthesized in a conventional manner by assembling ten peptide fragments followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio, 1:1) in trifluoroacetic acid in the presence of m-cresol and dimethylselenide.	trifluoromethanesulfonic acid-thioanisole	138-179	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	22-25
3139749-6	1988	In addition, a gold salt currently used for therapy of chronic inflammation, auranofin, induced hsp and inhibited IL-1 beta biosynthesis, whereas a second salt, sodium aurothiomalate, did neither.	Salts	20-24	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	96-99
3139749-6	1988	In addition, a gold salt currently used for therapy of chronic inflammation, auranofin, induced hsp and inhibited IL-1 beta biosynthesis, whereas a second salt, sodium aurothiomalate, did neither.	Auranofin	77-86	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	96-99
3312423-5	1987	In sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the purified HSP consisted of two proteins (70 and 62 kilodaltons [kd]), but only the 62-kd protein was detected in the 15,000 g supernatant fraction of the extract using the immunoblotting technique.	polyacrylamide	26-40	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-78
3312423-6	1987	The amino acid composition of the purified HSP included 30% glycine, 15% serine, 12% glutamic acid, and 4% ornithine, but only 2.3% histidine.	Glycine	60-67	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-46
3312423-6	1987	The amino acid composition of the purified HSP included 30% glycine, 15% serine, 12% glutamic acid, and 4% ornithine, but only 2.3% histidine.	Serine	73-79	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-46
3312423-6	1987	The amino acid composition of the purified HSP included 30% glycine, 15% serine, 12% glutamic acid, and 4% ornithine, but only 2.3% histidine.	Ornithine	107-116	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-46
3332481-8	1987	Other experiments suggest such hsp inducers as heat, ethanol, arsenite, or oxygenation after anoxia, may cause protein damage through oxygen-derived free radical action.	Ethanol	53-60	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
3332481-8	1987	Other experiments suggest such hsp inducers as heat, ethanol, arsenite, or oxygenation after anoxia, may cause protein damage through oxygen-derived free radical action.	arsenite	62-70	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
3332481-8	1987	Other experiments suggest such hsp inducers as heat, ethanol, arsenite, or oxygenation after anoxia, may cause protein damage through oxygen-derived free radical action.	Oxygen	75-81	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
3332481-8	1987	Other experiments suggest such hsp inducers as heat, ethanol, arsenite, or oxygenation after anoxia, may cause protein damage through oxygen-derived free radical action.	Free Radicals	149-161	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
5755928-0	1968	Effect of atropine and HSp 2986 on parotid secretion under stimulation by acetyl- beta-methylcholine.	Methacholine Chloride	74-100	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	23-26
3782091-4	1986	Addition of puromycin to these cells resulted in the release of all ribosomes from HSP 70 mRNA, indicating that they were translationally active.	Puromycin	12-21	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	83-86
2984220-0	1985	Antagonistic effects of insulin and dexamethasone on glucose-regulated and heat shock protein synthesis.	Dexamethasone	36-49	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-93
2984220-3	1985	Physiol., 114:93-98, 1983), that dexamethasone inhibits the alterations in heat shock protein (HSP) and glucose-regulated protein (GRP) synthesis caused by glucose deprivation.	Dexamethasone	33-46	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-93
2984220-3	1985	Physiol., 114:93-98, 1983), that dexamethasone inhibits the alterations in heat shock protein (HSP) and glucose-regulated protein (GRP) synthesis caused by glucose deprivation.	Dexamethasone	33-46	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	95-98
2984220-7	1985	These data suggest that the changes in GRP and HSP synthesis induced by glucose deprivation and heat shock, respectively, may reflect the operation of a normal physiological mechanism that regulates glucose metabolism.	Glucose	72-79	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	47-50
10278008-0	1980	Dealing with HSA"S: Oaklawn hospital organizes campaign to change HSP.	Altretamine	13-16	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	66-69
4460118-0	1974	[Use of the anticholinergic and antispasmodic agent pramiverin (HSp 2986, E. Merck) to obtain medical vagotomy].	pramiverine	52-62	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-67
6611860-9	1983	Heat shock protein (HSP) synthesis is lessened by treatment with buthionine sulfoximine; the extent of the decrease in HSP production correlates with the decrease in thermotolerance.	Buthionine Sulfoximine	65-87	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-18
6611860-9	1983	Heat shock protein (HSP) synthesis is lessened by treatment with buthionine sulfoximine; the extent of the decrease in HSP production correlates with the decrease in thermotolerance.	Buthionine Sulfoximine	65-87	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	20-23
6611860-9	1983	Heat shock protein (HSP) synthesis is lessened by treatment with buthionine sulfoximine; the extent of the decrease in HSP production correlates with the decrease in thermotolerance.	Buthionine Sulfoximine	65-87	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	119-122
33909122-6	2021	In the present review, the focus is shifted on the role of these molecules under heat stress emphasizing the different possible interactions between ABA and NO as both regulate stomatal closure and other molecules including hydrogen peroxide (H2O2), hydrogen sulfide (H2S), antioxidants, proline, glycine betaine, calcium (Ca2+) and heat shock protein (HSP).	Abscisic Acid	149-152	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	333-351
33909122-6	2021	In the present review, the focus is shifted on the role of these molecules under heat stress emphasizing the different possible interactions between ABA and NO as both regulate stomatal closure and other molecules including hydrogen peroxide (H2O2), hydrogen sulfide (H2S), antioxidants, proline, glycine betaine, calcium (Ca2+) and heat shock protein (HSP).	Abscisic Acid	149-152	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	353-356
33246089-4	2021	In this study, the application of HSP/HSC70 inhibitor VER155008 is virus infectious phase-dependent for figuring out the role of intact molecular chaperone HSP/HSC70 activity in different stages of BmNPV proliferation progress.	VER 155008	54-63	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	34-37
33246089-4	2021	In this study, the application of HSP/HSC70 inhibitor VER155008 is virus infectious phase-dependent for figuring out the role of intact molecular chaperone HSP/HSC70 activity in different stages of BmNPV proliferation progress.	VER 155008	54-63	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	156-159
33500390-0	2021	The HSP-RTK-Akt axis mediates acquired resistance to Ganetespib in HER2-positive breast cancer.	STA 9090	53-63	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	4-7
33603951-7	2021	New pathophysiological mechanisms involving ROS are being discovered and described the protein network of HSP interactions.	Reactive Oxygen Species	44-47	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	106-109
33176674-7	2020	CONCLUSIONS: The RNA-sequencing analysis indicated that H2O2 treatment promoted the early ripening of Kyoho berry by affecting the expression levels of HSP, GDSL, XTH, and CAB1 and- photosynthesis- pathways.	Hydrogen Peroxide	56-60	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	152-155
33456581-5	2021	Regulation of the HSP system was investigated by immunoprecipitation, drug affinity responsive target stability assay, binding experiments using ATP-agarose beads and biotinylated drug, and docking analysis.	Adenosine Triphosphate	145-148	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-21
33456581-5	2021	Regulation of the HSP system was investigated by immunoprecipitation, drug affinity responsive target stability assay, binding experiments using ATP-agarose beads and biotinylated drug, and docking analysis.	Sepharose	149-156	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-21
33456581-9	2021	Mechanistically, Evo disrupted the HSP system by binding the N-terminal ATP-binding pocket of HSP70 and causing its ubiquitin-mediated degradation.	evodiamine	17-20	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	35-38
33456581-9	2021	Mechanistically, Evo disrupted the HSP system by binding the N-terminal ATP-binding pocket of HSP70 and causing its ubiquitin-mediated degradation.	Adenosine Triphosphate	72-75	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	35-38
33176674-7	2020	CONCLUSIONS: The RNA-sequencing analysis indicated that H2O2 treatment promoted the early ripening of Kyoho berry by affecting the expression levels of HSP, GDSL, XTH, and CAB1 and- photosynthesis- pathways.	kyoho	102-107	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	152-155
32180126-0	2020	Correction to: Astaxanthin supplementation impacts the cellular HSP expression profile during passive heating.	astaxanthine	15-26	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-67
32518242-3	2020	Hesperidin loaded on gold nanoparticles (Hsp-AuNPs) was prepared by a chemical synthesis method.	Hesperidin	0-10	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	41-44
32518242-5	2020	The cytotoxic effect of Hsp-AuNPs on human breast cancer cell line (MDA-MB-231) was assessed using MTT and crystal violet assays.	monooxyethylene trimethylolpropane tristearate	99-102	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	24-27
32518242-5	2020	The cytotoxic effect of Hsp-AuNPs on human breast cancer cell line (MDA-MB-231) was assessed using MTT and crystal violet assays.	Gentian Violet	107-121	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	24-27
32934719-2	2020	The original structures of geldanamycin and radicicol, which are known natural heat shock protein (HSP) inhibitors, were deeply modified because both of them exhibit several drawbacks, such as poor solubility, hepatotoxicity, intrinsic chemical instability or deprivation of the in vivo activity.	geldanamycin	27-39	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	79-97
32934719-2	2020	The original structures of geldanamycin and radicicol, which are known natural heat shock protein (HSP) inhibitors, were deeply modified because both of them exhibit several drawbacks, such as poor solubility, hepatotoxicity, intrinsic chemical instability or deprivation of the in vivo activity.	geldanamycin	27-39	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	99-102
32934719-2	2020	The original structures of geldanamycin and radicicol, which are known natural heat shock protein (HSP) inhibitors, were deeply modified because both of them exhibit several drawbacks, such as poor solubility, hepatotoxicity, intrinsic chemical instability or deprivation of the in vivo activity.	monorden	44-53	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	79-97
32934719-2	2020	The original structures of geldanamycin and radicicol, which are known natural heat shock protein (HSP) inhibitors, were deeply modified because both of them exhibit several drawbacks, such as poor solubility, hepatotoxicity, intrinsic chemical instability or deprivation of the in vivo activity.	monorden	44-53	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	99-102
32698370-4	2020	Such an HSP inducing compound is L-glutamine.	Glutamine	33-44	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	8-11
31731530-4	2019	Moreover, HSP also enhances membrane stability and detoxifies the reactive oxygen species (ROS) by positively regulating the antioxidant enzymes system.	Oxygen	75-81	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	10-13
32093696-12	2020	CONCLUSION: Challenges in policy and supply at the national level and HSP preparedness at the sub-national levels contribute to the slow adoption of WHO recommendations for amoxicillin DT in Bangladesh.	amoxicillin dt	173-187	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	70-73
31971027-3	2020	The observations are very promising in the early stages of clinical trials with HSP inhibitors, such as tanespimycin, in the relapsed/refractory MM patients.	tanespimycin	104-116	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
31297844-0	2019	The androgen receptor antagonist enzalutamide induces apoptosis, dysregulates the heat shock protein system, and diminishes the androgen receptor and estrogen receptor beta1 expression in prostate cancer cells.	enzalutamide	33-45	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	82-100
31297844-11	2019	According to an indirect attenuation of HSP-associated factors such as steroid receptors, endometrial carcinoma, uterine leiomyosarcoma, and mamma carcinoma cells also demonstrated inhibited cell growth in the presence of enzalutamide.	enzalutamide	222-234	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	40-43
30603780-0	2019	Cabazitaxel inhibits prostate cancer cell growth by inhibition of androgen receptor and heat shock protein expression.	cabazitaxel	0-11	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	88-106
31026955-5	2019	Theh Guth and Gold equation showed mechanical reinforcement of porous silicone/HSP composites was primarily due to the hydrodynamic effect of HSPs in the silicone matrix at low HSP contents (Phi < 0.5).	Silicones	70-78	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	142-145
31026955-5	2019	Theh Guth and Gold equation showed mechanical reinforcement of porous silicone/HSP composites was primarily due to the hydrodynamic effect of HSPs in the silicone matrix at low HSP contents (Phi < 0.5).	Silicones	154-162	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	79-82
31026955-5	2019	Theh Guth and Gold equation showed mechanical reinforcement of porous silicone/HSP composites was primarily due to the hydrodynamic effect of HSPs in the silicone matrix at low HSP contents (Phi < 0.5).	Silicones	154-162	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	142-145
30603780-2	2019	Since cabazitaxel has also been demonstrated to inhibit androgen receptor (AR) functionality, AR and AR-associated heat shock protein (HSP) expressions in the presence of cabazitaxel were characterized.	cabazitaxel	171-182	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	135-138
30603780-7	2019	CONCLUSIONS: Despite the deregulation of microtubule organisation, cabazitaxel has been shown to suppress the expression of HSP.	cabazitaxel	67-78	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	124-127
30603780-8	2019	Very notably, and may be as a result of down-regulated HSP, cabazitaxel additionally inhibits the expression of the AR in AR-positive PC cells.	cabazitaxel	60-71	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	55-58
31302117-5	2019	Hence, the HSP-inducing compound geranylgeranylacetone (GGA) and its derivatives protect against proteostasis derailment in experimental models for AF.	geranylgeranylacetone	33-54	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	11-14
31302117-13	2019	CONCLUSIONS: Our results imply that the HSP inducer GGA*-59 and recombinant HSPB1 accelerate recovery from TP-induced structural remodeling and contractile dysfunction in HL-1 cardiomyocytes.	tp	107-109	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	40-43
30705583-1	2019	Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems.	geranylgeranylacetone	50-71	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	16-34
31054961-3	2019	However, the roles and regulatory mechanisms by which CsA modulates HSP expression remain largely unknown.	Cyclosporine	54-57	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	68-71
31054961-5	2019	Suppression of ERK1/2, GSK3beta and CK2 activities attenuated CsA-induced down-regulation of HSP expression and up-regulation of HSF1 phosphorylation.	Cyclosporine	62-65	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	93-96
31054961-8	2019	These results indicate that CsA suppresses HSP induction during heat shock by regulating the phosphorylation and nuclear translocation of HSF1.	Cyclosporine	28-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-46
31089638-0	2019	New geldanamycin derivatives with anti Hsp properties by mutasynthesis.	geldanamycin	4-16	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	39-42
31027887-6	2019	Remarkably, Hsp104A503S exhibits altered coupling of ATP binding to translocation and decelerated dissociation from polypeptide substrate compared to Hsp104.	Adenosine Triphosphate	53-56	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-15
30776355-6	2019	Stat3 phosphorylation and Hsp induction were inhibited by AG490, an inhibitor of JAK tyrosine kinase.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	58-63	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	26-29
31307055-3	2019	Objective: To compare outcomes between continuous administration of anticoagulants (CA) with CSP (CA+CSP) and periprocedural heparin bridging (HB) with HSP (HB+HSP) for subcentimeter colorectal polyps.	Heparin	125-132	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	157-163
31290616-4	2019	Finally, gambogic acid (GA), a type of heat-shock protein (HSP) inhibitor, which is vital to cells resisting heating-caused damage is loaded, into Bi2 Se3 HNC.	gambogic acid	9-22	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	39-57
31290616-4	2019	Finally, gambogic acid (GA), a type of heat-shock protein (HSP) inhibitor, which is vital to cells resisting heating-caused damage is loaded, into Bi2 Se3 HNC.	gambogic acid	9-22	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	59-62
31290616-4	2019	Finally, gambogic acid (GA), a type of heat-shock protein (HSP) inhibitor, which is vital to cells resisting heating-caused damage is loaded, into Bi2 Se3 HNC.	gambogic acid	24-26	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	39-57
31290616-4	2019	Finally, gambogic acid (GA), a type of heat-shock protein (HSP) inhibitor, which is vital to cells resisting heating-caused damage is loaded, into Bi2 Se3 HNC.	gambogic acid	24-26	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	59-62
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	Polyphenols	19-30	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	caffeic acid	78-90	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	(-)-epicatechin-3-(3"-o-methyl)-gallic acid	98-141	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	quercetin-acetyl-rutinoside hexoside	149-185	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	gallocatechol	187-207	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	Rutin	166-171	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	catechin trimer	240-255	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	Chlorogenic Acid	260-281	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
30529121-3	2019	HSP significantly inhibited the proliferation of HeLa cells in vitro, and induced intracellular ROS accumulation.	ros	96-99	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
30705583-1	2019	Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems.	geranylgeranylacetone	50-71	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-39
30705583-1	2019	Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems.	geranylgeranylacetone	73-76	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	16-34
30705583-1	2019	Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems.	geranylgeranylacetone	73-76	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-39
29177651-2	2018	In order to study whether the members of the heat shock protein (HSP) families, by virtue of their molecular chaperone activity, can inhibit the formation of polyQ aggregates, we developed a cell culture model expressing the GFP tagged fragment of exon1 of the huntingtin gene with an expanded polyQ chain and tetracycline inducible chaperones.	polyglutamine	158-163	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	45-63
30242929-8	2018	Here, we hypothesize that CS could induce oxidative stress and cytotoxicity in lung epithelial cells through alterations of heat shock protein (HSP) expression and mitogen-activated protein kinase (MAPK) signalling pathways.	Cesium	26-28	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	124-142
30242929-8	2018	Here, we hypothesize that CS could induce oxidative stress and cytotoxicity in lung epithelial cells through alterations of heat shock protein (HSP) expression and mitogen-activated protein kinase (MAPK) signalling pathways.	Cesium	26-28	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	144-147
29674508-11	2018	Diverse effects of vemurafenib-XL888 upon intratumoral HSP client protein expression were noted, with the expression of multiple proteins (including ERBB3 and BAD) modulated on therapy.Conclusions: XL888 in combination with vemurafenib has clinical activity in patients with advanced BRAFV600-mutant melanoma, with a tolerable side-effect profile.	Vemurafenib	19-30	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	55-58
29674508-11	2018	Diverse effects of vemurafenib-XL888 upon intratumoral HSP client protein expression were noted, with the expression of multiple proteins (including ERBB3 and BAD) modulated on therapy.Conclusions: XL888 in combination with vemurafenib has clinical activity in patients with advanced BRAFV600-mutant melanoma, with a tolerable side-effect profile.	XL 888	31-36	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	55-58
29733104-10	2018	Also, use of the fractional CO2 laser increased HSP (heat shock protein) 70 and collagen type I synthesis.	Carbon Dioxide	28-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	48-51
29500978-7	2018	More importantly, LIP-PFOB-ICG inhibited MDA-MB-231 tumor growth completely via intravenous injection through enhanced PDT&PTT synergistic therapy due to the excellent oxygen carrying ability of PFOB, which effectively attenuated tumor hypoxia, improved the efficiency of collisional energy transfer between ICG and oxygen and reduced the expression of heat shock protein (HSP).	perflubron	22-26	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	357-375
29500978-7	2018	More importantly, LIP-PFOB-ICG inhibited MDA-MB-231 tumor growth completely via intravenous injection through enhanced PDT&PTT synergistic therapy due to the excellent oxygen carrying ability of PFOB, which effectively attenuated tumor hypoxia, improved the efficiency of collisional energy transfer between ICG and oxygen and reduced the expression of heat shock protein (HSP).	perflubron	22-26	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	377-380
29500978-7	2018	More importantly, LIP-PFOB-ICG inhibited MDA-MB-231 tumor growth completely via intravenous injection through enhanced PDT&PTT synergistic therapy due to the excellent oxygen carrying ability of PFOB, which effectively attenuated tumor hypoxia, improved the efficiency of collisional energy transfer between ICG and oxygen and reduced the expression of heat shock protein (HSP).	Indocyanine Green	27-30	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	357-375
29500978-7	2018	More importantly, LIP-PFOB-ICG inhibited MDA-MB-231 tumor growth completely via intravenous injection through enhanced PDT&PTT synergistic therapy due to the excellent oxygen carrying ability of PFOB, which effectively attenuated tumor hypoxia, improved the efficiency of collisional energy transfer between ICG and oxygen and reduced the expression of heat shock protein (HSP).	Indocyanine Green	27-30	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	377-380
30151300-1	2018	Objective: It has been attempted to find out that Homine Placents and Soyeom mixed Pharmacopuncture (HSP) procedure is effective for the removal of melanocytic nevus of considerable size which cannot be applied to general acupuncture.	homine	50-56	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	101-104
29802537-1	2018	A pull-down experiment (co-immunoprecipitation) was performed on a T24 human bladder cancer cell lysate treated with the Hsp inhibitor VER155008 using an Hsp70 antibody attached to Dynabeads.	VER 155008	135-144	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	121-124
29177651-2	2018	In order to study whether the members of the heat shock protein (HSP) families, by virtue of their molecular chaperone activity, can inhibit the formation of polyQ aggregates, we developed a cell culture model expressing the GFP tagged fragment of exon1 of the huntingtin gene with an expanded polyQ chain and tetracycline inducible chaperones.	polyglutamine	158-163	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	65-68
29177651-2	2018	In order to study whether the members of the heat shock protein (HSP) families, by virtue of their molecular chaperone activity, can inhibit the formation of polyQ aggregates, we developed a cell culture model expressing the GFP tagged fragment of exon1 of the huntingtin gene with an expanded polyQ chain and tetracycline inducible chaperones.	polyglutamine	294-299	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	45-63
29177651-2	2018	In order to study whether the members of the heat shock protein (HSP) families, by virtue of their molecular chaperone activity, can inhibit the formation of polyQ aggregates, we developed a cell culture model expressing the GFP tagged fragment of exon1 of the huntingtin gene with an expanded polyQ chain and tetracycline inducible chaperones.	polyglutamine	294-299	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	65-68
29177651-2	2018	In order to study whether the members of the heat shock protein (HSP) families, by virtue of their molecular chaperone activity, can inhibit the formation of polyQ aggregates, we developed a cell culture model expressing the GFP tagged fragment of exon1 of the huntingtin gene with an expanded polyQ chain and tetracycline inducible chaperones.	Tetracycline	310-322	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	45-63
29177651-2	2018	In order to study whether the members of the heat shock protein (HSP) families, by virtue of their molecular chaperone activity, can inhibit the formation of polyQ aggregates, we developed a cell culture model expressing the GFP tagged fragment of exon1 of the huntingtin gene with an expanded polyQ chain and tetracycline inducible chaperones.	Tetracycline	310-322	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	65-68
27503726-6	2016	Then the chicks were exposed to an acute HT (40+-1 C for 3h) to examine the effect of flavangenol on the mRNA expression of heat-shock protein (HSP) in the brain and liver.	flavangenol	86-97	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	124-142
30428468-6	2018	PLS and hSP patients had similar CSF and serum pNfH concentrations, but a higher CSF pNfH concentration, compared to HC (p = 0.002 and p = 0.003 for PLS and hSP, respectively).	pnfh	47-51	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	8-11
30428468-6	2018	PLS and hSP patients had similar CSF and serum pNfH concentrations, but a higher CSF pNfH concentration, compared to HC (p = 0.002 and p = 0.003 for PLS and hSP, respectively).	pnfh	85-89	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	8-11
28439947-0	2017	SIRT1/HSF1/HSP pathway is essential for exenatide-alleviated, lipid-induced hepatic endoplasmic reticulum stress.	Exenatide	40-49	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	11-14
28439947-9	2017	Finally, inhibition of SIRT1 by genetic whole-body heterozygous knockout or by lentiviral short hairpin RNA knockdown greatly diminished the effect of exenatide on deacetylating heat shock factor 1, increasing HSP expression and alleviating ER stress and hepatic steatosis in HFD-fed mice.	Exenatide	151-160	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	210-213
28439947-10	2017	CONCLUSION: The SIRT1/heat shock factor 1/HSP pathway is essential for exenatide-alleviated, lipid-induced ER stress and hepatic steatosis, which provides evidence for a molecular mechanism to support exenatide and incretin mimetics as promising therapeutics for obesity-induced hepatic steatosis.	Exenatide	71-80	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	42-45
28814727-6	2017	These analyses revealed that CSE and acrolein induced hSP-A oligomerisation and that acrolein induced the modification of six residues in hSP-A: His39, His116, Cys155, Lys180, Lys221, and Cys224.	Acrolein	37-45	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	54-57
27273088-7	2016	Celastrol activates heat shock transcription factor 1 (HSF1), the master regulator of Hsp gene transcription, and also exhibits potent anti-inflammatory and anti-oxidant activities.	celastrol	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	86-89
27273088-8	2016	Arimoclomol is a co-activator that prolongs the binding of activated HSF1 to heat shock elements (HSEs) in the promoter regions of inducible Hsp genes.	arimoclomol	0-11	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	141-144
27273088-10	2016	Co-application of celastrol and arimoclomol induced higher Hsp levels compared to heat shock paired with arimoclomol.	celastrol	18-27	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	59-62
27273088-10	2016	Co-application of celastrol and arimoclomol induced higher Hsp levels compared to heat shock paired with arimoclomol.	arimoclomol	32-43	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	59-62
28439947-10	2017	CONCLUSION: The SIRT1/heat shock factor 1/HSP pathway is essential for exenatide-alleviated, lipid-induced ER stress and hepatic steatosis, which provides evidence for a molecular mechanism to support exenatide and incretin mimetics as promising therapeutics for obesity-induced hepatic steatosis.	Exenatide	201-210	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	42-45
28417222-6	2017	In addition, we introduce a mitohormetic role of gamitrinib-triphenylphosphonium (G-TPP), a mitochondrial heat shock protein (Hsp) inhibitor that can induce mild mitochondrial stress to protect cells from future insults in a FOXO-dependent manner.	gamitrinib-triphenylphosphonium	49-80	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	106-124
28417222-6	2017	In addition, we introduce a mitohormetic role of gamitrinib-triphenylphosphonium (G-TPP), a mitochondrial heat shock protein (Hsp) inhibitor that can induce mild mitochondrial stress to protect cells from future insults in a FOXO-dependent manner.	gamitrinib-triphenylphosphonium	49-80	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	126-129
28417222-6	2017	In addition, we introduce a mitohormetic role of gamitrinib-triphenylphosphonium (G-TPP), a mitochondrial heat shock protein (Hsp) inhibitor that can induce mild mitochondrial stress to protect cells from future insults in a FOXO-dependent manner.	gamitrinib-triphenylphosphonium	82-87	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	106-124
28417222-6	2017	In addition, we introduce a mitohormetic role of gamitrinib-triphenylphosphonium (G-TPP), a mitochondrial heat shock protein (Hsp) inhibitor that can induce mild mitochondrial stress to protect cells from future insults in a FOXO-dependent manner.	gamitrinib-triphenylphosphonium	82-87	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	126-129
28291803-7	2017	Combination of the Hsp70-inducing inhibitors of Hsp90 with known inhibitors of the Hsp induction such as quercetin, triptolide, KNK437, NZ28 prevented up-regulation of Hsp70 in the cancer cells thereby increasing their post-radiation apoptotic/necrotic death and decreasing their post-radiation viability/clonogenicity.	Quercetin	105-114	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	19-22
28291803-7	2017	Combination of the Hsp70-inducing inhibitors of Hsp90 with known inhibitors of the Hsp induction such as quercetin, triptolide, KNK437, NZ28 prevented up-regulation of Hsp70 in the cancer cells thereby increasing their post-radiation apoptotic/necrotic death and decreasing their post-radiation viability/clonogenicity.	triptolide	116-126	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	19-22
27639309-2	2016	Gaining insight into the native presentation and distribution of glycans across hSP could help establish molecular environments supporting specific biological activities based on unique ligand capacities.	Polysaccharides	65-72	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
27639309-4	2016	Common O- and N-glycosylated species were detected on mixed or overlapped underlying protein scaffolds in both soluble and particulate fractions of hSP.	Nitrogen	14-15	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	148-151
27639309-7	2016	Insight into the complexity of hSP glycans as recognition signals under normal physiological conditions could be of interest for regulation and possible modulation of its biological activity, as well as for biomarker potential related to male health.	Polysaccharides	35-42	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
27021964-10	2016	Further, with the support of in vivo and in vitro studies, we discuss the putative molecular mechanisms underlying the ROS-mediated modulation of HSP expression and/or activity during exercise.	ros	119-122	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	146-149
27503726-6	2016	Then the chicks were exposed to an acute HT (40+-1 C for 3h) to examine the effect of flavangenol on the mRNA expression of heat-shock protein (HSP) in the brain and liver.	flavangenol	86-97	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	144-147
26263495-10	2015	The PDA polymer chain therefore grows in the same direction in which the HSP molecules are aligned.	pda polymer	4-15	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	73-76
26643660-10	2016	CONCLUSION: The HSP inducing compound, paeoniflorin, had a relaxant effect on human uterine contractility in vitro.	peoniflorin	39-51	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	16-19
27199993-4	2016	The interaction of HSP-peptide complexes or peptide-free HSPs with receptors on antigen-presenting cells promotes the maturation of dendritic cells, results in an upregulation of major histocompatibility complex class I and class II molecules, induces secretion of pro- and anti-inflammatory cytokines, chemokines, and immune modulatory nitric oxides, and thus integrates adaptive and innate immune phenomena.	Nitric Oxide	337-350	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	19-22
27041924-0	2016	Heat shock protein inhibitor, quercetin, as a novel adjuvant agent to improve radiofrequency ablation-induced tumor destruction and its molecular mechanism.	Quercetin	30-39	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-18
26787517-4	2016	By using site-specific Fluorine-19 nuclear magnetic resonance experiments guided by in vivo crosslinking studies, we now reveal that the partial unfolding of Hsp33"s linker region facilitates client binding to an amphipathic docking surface on Hsp33.	Fluorine	23-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	158-161
26504004-3	2015	Results showed that a large number of genes belonging to the heat shock protein (HSP) super-family were up-regulated following treatment, specifically with CBD.	Cannabidiol	156-159	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	61-79
26504004-3	2015	Results showed that a large number of genes belonging to the heat shock protein (HSP) super-family were up-regulated following treatment, specifically with CBD.	Cannabidiol	156-159	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
26504004-4	2015	Increases were observed both at the gene and protein levels and arose as a consequence of increased generation of ROS by CBD, and correlated with an increase in a number of HSP client proteins.	ros	114-117	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	173-176
25957169-5	2015	Novel humanized SP-A2-transgenic mice harboring the hSP-A2 223K allele exhibit reduced neutrophil influx and mucin production in the lungs when challenged with MMF compared with SP-A(-/-) mice.	mmf	160-163	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	52-55
25857363-3	2015	We also evaluated the effects of 0.4 mM aspirin (ASA) as a potential pharmacological co-inducer of HSP, both alone and in a combination with HS (ASA + HS).	Aspirin	49-52	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	99-102
26579577-4	2015	Herein, we report that incubation of PANC-1 cells with N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) or with L-kynurenine (L-KYN) lead to the overexpression of heat shock protein synthesis and these effects are partially reversed by 5-HT3 or MT1/MT2 receptor antagonists.	n(1)-acetyl-n(2)-formyl-5-methoxykynuramine	55-98	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	165-183
26579577-4	2015	Herein, we report that incubation of PANC-1 cells with N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) or with L-kynurenine (L-KYN) lead to the overexpression of heat shock protein synthesis and these effects are partially reversed by 5-HT3 or MT1/MT2 receptor antagonists.	Kynurenine	114-126	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	165-183
26579577-4	2015	Herein, we report that incubation of PANC-1 cells with N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) or with L-kynurenine (L-KYN) lead to the overexpression of heat shock protein synthesis and these effects are partially reversed by 5-HT3 or MT1/MT2 receptor antagonists.	Kynurenine	128-133	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	165-183
26579577-8	2015	Pretreatment of cell cultures with luzindole or MDL72222 followed by the addition of AFMK or L-KYN reversed the stimulatory effects of these substances on HSP expression in PANC-1 cells, whereas ketanserin failed to influence mentioned above phenomenon.	luzindole	35-44	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	155-158
25145901-14	2015	These results further suggest that perturbations in Hsp metabolism may induce mucosal injury in response to oxygen free radicals.	oxygen free radicals	108-128	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	52-55
25505263-0	2015	Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation enzyme folding and function.	Fatty Acids	150-160	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	29-47
25505263-3	2015	Because the heat shock protein (Hsp) Hsp10-Hsp60 chaperone complex mediates folding of the fatty acid oxidation enzyme medium-chain acyl-CoA dehydrogenase, we tested whether acetylation-dependent mitochondrial protein folding contributes to this regulatory discrepancy.	Fatty Acids	91-101	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-30
25505263-3	2015	Because the heat shock protein (Hsp) Hsp10-Hsp60 chaperone complex mediates folding of the fatty acid oxidation enzyme medium-chain acyl-CoA dehydrogenase, we tested whether acetylation-dependent mitochondrial protein folding contributes to this regulatory discrepancy.	Fatty Acids	91-101	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	32-35
24849281-9	2014	The DBS solvent phases tend to cluster in regions of Hansen space and are highly influenced by the hydrogen-bonding HSP, delta(h).	dibenzylidene sorbitol	4-7	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	116-119
24849281-9	2014	The DBS solvent phases tend to cluster in regions of Hansen space and are highly influenced by the hydrogen-bonding HSP, delta(h).	Hydrogen	99-107	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	116-119
24849281-10	2014	It is also found that the fate of this molecular gelator, unlike that of polymers, is influenced not only by the magnitude of the distance between the HSPs for DBS and the HSPs of the solvent, R(ij), but also by the directionality of R(ij): if the solvent has a larger hydrogen-bonding HSP (indicating stronger H-bonding) than that of the DBS, then clear gels are formed; opaque gels form when the solvent has a lower delta(h) than does DBS.	dibenzylidene sorbitol	160-163	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	151-154
24244355-7	2013	PFT-mu decreased the viabilities of all cell lines at one-tenth the dose of Quercetin, a well-known HSP inhibitor.	Quercetin	76-85	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	100-103
24349573-2	2013	From our experiments in dilute aluminum and silica containing solutions (pH ~ 7) we previously identified a silica polymer with an extraordinarily high affinity for aluminium ions (high-aluminum-affinity silica polymer, HSP).	Aluminum	31-39	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	220-223
24349573-2	2013	From our experiments in dilute aluminum and silica containing solutions (pH ~ 7) we previously identified a silica polymer with an extraordinarily high affinity for aluminium ions (high-aluminum-affinity silica polymer, HSP).	Silicon Dioxide	44-50	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	220-223
24349573-2	2013	From our experiments in dilute aluminum and silica containing solutions (pH ~ 7) we previously identified a silica polymer with an extraordinarily high affinity for aluminium ions (high-aluminum-affinity silica polymer, HSP).	silica polymer	108-122	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	220-223
24349573-2	2013	From our experiments in dilute aluminum and silica containing solutions (pH ~ 7) we previously identified a silica polymer with an extraordinarily high affinity for aluminium ions (high-aluminum-affinity silica polymer, HSP).	Aluminum	165-174	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	220-223
24349573-2	2013	From our experiments in dilute aluminum and silica containing solutions (pH ~ 7) we previously identified a silica polymer with an extraordinarily high affinity for aluminium ions (high-aluminum-affinity silica polymer, HSP).	Aluminum	186-194	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	220-223
24349573-3	2013	Here, further characterization shows that HSP is a colloid of approximately 2.4 nm in diameter with a mean specific surface area of about 1,000 m(2) g(-1) and it competes effectively with transferrin for Al(III) binding.	al(iii)	204-211	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	42-45
24349573-4	2013	Aluminum binding to HSP strongly inhibited its decomposition whilst the reaction rate constant for the formation of the beta-silicomolybdic acid complex indicated a diameter between 3.6 and 4.1 nm for these aluminum-containing nanoparticles.	Aluminum	0-8	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	20-23
24349573-4	2013	Aluminum binding to HSP strongly inhibited its decomposition whilst the reaction rate constant for the formation of the beta-silicomolybdic acid complex indicated a diameter between 3.6 and 4.1 nm for these aluminum-containing nanoparticles.	Aluminum	207-215	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	20-23
25120620-0	2014	Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70.	BEP800	89-95	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	53-71
25120620-0	2014	Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70.	BEP800	89-95	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	192-210
25120620-1	2014	The present study aimed to investigate the effect of NVP-BEP800, a novel heat shock protein (Hsp) 90 inhibitor of the 2-aminothieno[2,3-d]pyrimidine class, in combination with radiation on glioblastoma cells.	2-aminothieno[2,3-d]pyrimidine	118-148	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	93-96
23957557-4	2014	Given the combination of physiological stresses induced by exercise, and the "cross-talk" that occurs between signaling pathways in different tissues, it is likely that exercise induces the HSP expression through a combination of "stressors", among which reactive oxygen species (ROS) could play a major role.	Reactive Oxygen Species	255-278	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	190-193
23957557-4	2014	Given the combination of physiological stresses induced by exercise, and the "cross-talk" that occurs between signaling pathways in different tissues, it is likely that exercise induces the HSP expression through a combination of "stressors", among which reactive oxygen species (ROS) could play a major role.	Reactive Oxygen Species	280-283	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	190-193
23957557-7	2014	The aim of this review is to provide a critical update on the role of exercise-induced ROS in the modulation of the HSP"s response, focusing on experimental results from animal and human studies where the link between redox homeostasis and HSPs" expression in different tissues has been addressed.	Reactive Oxygen Species	87-90	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	116-119
24103518-0	2013	L-Threonine induces heat shock protein expression and decreases apoptosis in heat-stressed intestinal epithelial cells.	Threonine	0-11	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	20-38
24103518-17	2013	THR"s mechanism of protection may involve cytoskeletal stabilization, HSP up-regulation and nuclear translocation, and decreased apoptosis.	Threonine	0-3	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	70-73
23602864-11	2013	In DU145 tumor bearing mice, a single treatment of tumor hyperthermia, induced via gold nanorod mediated plasmonic photothermal therapy, and intravenous administration of HSP targeted HPMA copolymer-docetaxel at 10mg/kg resulted in maintained tumor regression for a period of 30 days.	Docetaxel	199-208	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	171-174
23810294-1	2013	Celastrol (CEL) is known as a potent inducer of heat shock protein (HSP) in non-muscle cells and exhibits cytoprotective function and inhibitory effects on proteasome and glucocorticoid receptor activities.	celastrol	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	48-66
23810294-1	2013	Celastrol (CEL) is known as a potent inducer of heat shock protein (HSP) in non-muscle cells and exhibits cytoprotective function and inhibitory effects on proteasome and glucocorticoid receptor activities.	celastrol	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	68-71
23810294-1	2013	Celastrol (CEL) is known as a potent inducer of heat shock protein (HSP) in non-muscle cells and exhibits cytoprotective function and inhibitory effects on proteasome and glucocorticoid receptor activities.	celastrol	11-14	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	48-66
23810294-1	2013	Celastrol (CEL) is known as a potent inducer of heat shock protein (HSP) in non-muscle cells and exhibits cytoprotective function and inhibitory effects on proteasome and glucocorticoid receptor activities.	celastrol	11-14	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	68-71
23602864-2	2013	In this study, tumor hyperthermia was utilized as a means to increase the active delivery of heat shock protein (HSP) targeted N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates.	N-(2-hydroxypropyl)methacrylamide	127-160	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	93-111
23602864-2	2013	In this study, tumor hyperthermia was utilized as a means to increase the active delivery of heat shock protein (HSP) targeted N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates.	N-(2-hydroxypropyl)methacrylamide	127-160	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	113-116
23602864-2	2013	In this study, tumor hyperthermia was utilized as a means to increase the active delivery of heat shock protein (HSP) targeted N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates.	N-(2-hydroxypropyl)methacrylamide	162-166	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	93-111
23602864-2	2013	In this study, tumor hyperthermia was utilized as a means to increase the active delivery of heat shock protein (HSP) targeted N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates.	N-(2-hydroxypropyl)methacrylamide	162-166	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	113-116
23602864-8	2013	HSP targeted DOC conjugates exhibited high potency against DU145 cells with an IC50 of 2.4 nM.	Docetaxel	13-16	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
23602864-10	2013	Based on these results, HSP targeted DOC conjugates were selected for in vivo evaluation.	Docetaxel	37-40	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	24-27
23812313-7	2013	In addition, the effects of geranylgeranylacetone were evaluated in terms of HSP expression and cytoskeleton changes.	geranylgeranylacetone	28-49	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	77-80
22621213-2	2012	Six types of HCC-targeted Hsp cages were chemically synthesized using two types of heterobifunctional linker (SM(PEG)(n)) with different lengths and two types of SP94 peptide, which contained a unique Cys residue at the N- or C-terminus of the peptide.	Polyethylene Glycols	113-116	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	26-29
23360166-0	2013	Effects of selenium-enriched probiotics on heat shock protein mRNA levels in piglet under heat stress conditions.	Selenium	11-19	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-61
22920902-0	2013	Hydroximic acid derivatives: pleiotropic HSP co-inducers restoring homeostasis and robustness.	hydroximic acid	0-15	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	41-44
23717042-2	2013	Mutant Hsp cages (HspG41C) were expressed in Escherichia coli by substituting glycine 41 located inside the cage with a cysteine residue to allow conjugation with a fluorophore or a drug.	Glycine	78-85	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	7-10
23717042-2	2013	Mutant Hsp cages (HspG41C) were expressed in Escherichia coli by substituting glycine 41 located inside the cage with a cysteine residue to allow conjugation with a fluorophore or a drug.	Cysteine	120-128	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	7-10
23533767-4	2013	Magnetite nanoparticles were conjugated with NPrCAP to introduce thermotherapeutic and immunotherapeutic effects through nonapoptotic cell death and generation of heat shock protein (HSP) upon exposure to alternating magnetic field (AMF).	Ferrosoferric Oxide	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	163-181
23533767-4	2013	Magnetite nanoparticles were conjugated with NPrCAP to introduce thermotherapeutic and immunotherapeutic effects through nonapoptotic cell death and generation of heat shock protein (HSP) upon exposure to alternating magnetic field (AMF).	Ferrosoferric Oxide	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	183-186
23533767-4	2013	Magnetite nanoparticles were conjugated with NPrCAP to introduce thermotherapeutic and immunotherapeutic effects through nonapoptotic cell death and generation of heat shock protein (HSP) upon exposure to alternating magnetic field (AMF).	N-propionyl-4-S-cysteaminylphenol	45-51	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	163-181
23533767-4	2013	Magnetite nanoparticles were conjugated with NPrCAP to introduce thermotherapeutic and immunotherapeutic effects through nonapoptotic cell death and generation of heat shock protein (HSP) upon exposure to alternating magnetic field (AMF).	N-propionyl-4-S-cysteaminylphenol	45-51	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	183-186
23530648-8	2013	PEITC therefore may be regarded as a potent HSP inhibitor and an antitumor agent in the treatment of breast cancer.	phenethyl isothiocyanate	0-5	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	44-47
22528773-5	2012	In addition, we evaluated the transcript and protein expression levels of two heat shock protein (HSP) members, Grp78 and Hsp70, to ascertain their suitability as biomarkers of TiO(2)NP-induced toxicity in the respiratory system.	tio(2)np	177-185	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	98-101
23596484-7	2013	The PSCA-HSPC and PSCA-HSP expressed in E. coli existed in soluble form, as confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).	Sodium Dodecyl Sulfate	89-111	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	9-12
23596484-7	2013	The PSCA-HSPC and PSCA-HSP expressed in E. coli existed in soluble form, as confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).	polyacrylamide	112-126	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	9-12
23596484-7	2013	The PSCA-HSPC and PSCA-HSP expressed in E. coli existed in soluble form, as confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).	Sodium Dodecyl Sulfate	148-151	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	9-12
23350198-2	2012	It was found that nanomolar concentrations of inhibitors of the HSP90 activity (17AAG or radicicol) slowed down chaperone-dependent reactivation of a thermo-labile reporter (luciferase) in heat-stressed HeLa cells and slightly enhanced their death following incubation for 60 min at 43 degrees C. Herein, the inhibitors of HSP90 activity stimulated de novo induction of additional chaperones (HSP70 and HSP27) that significantly increased the intracellular HSP levels.	tanespimycin	80-85	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-67
23350198-2	2012	It was found that nanomolar concentrations of inhibitors of the HSP90 activity (17AAG or radicicol) slowed down chaperone-dependent reactivation of a thermo-labile reporter (luciferase) in heat-stressed HeLa cells and slightly enhanced their death following incubation for 60 min at 43 degrees C. Herein, the inhibitors of HSP90 activity stimulated de novo induction of additional chaperones (HSP70 and HSP27) that significantly increased the intracellular HSP levels.	monorden	89-98	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-67
23350198-3	2012	If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating.	tanespimycin	31-36	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
23350198-3	2012	If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating.	monorden	40-49	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
23350198-3	2012	If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating.	Quercetin	101-110	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
23350198-3	2012	If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating.	triptolide	114-123	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
23350198-3	2012	If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating.	nz28	128-132	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
22621213-2	2012	Six types of HCC-targeted Hsp cages were chemically synthesized using two types of heterobifunctional linker (SM(PEG)(n)) with different lengths and two types of SP94 peptide, which contained a unique Cys residue at the N- or C-terminus of the peptide.	Cysteine	201-204	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	26-29
22621213-3	2012	These Hsp cages were characterized using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-ToF MS) analyses, sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analyses, and dynamic light scattering (DLS) measurement.	polyacrylamide	165-179	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	6-9
22621213-3	2012	These Hsp cages were characterized using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-ToF MS) analyses, sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analyses, and dynamic light scattering (DLS) measurement.	Sodium Dodecyl Sulfate	201-204	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	6-9
21732139-7	2012	RESULTS: HSP level was upregulated mediated by HSF1 when glioma cells were treated with PS-341.	Bortezomib	88-94	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	9-12
22322357-2	2012	Here, we address the question whether a heat-shock protein (HSP) co-inducer, insulin sensitizer drug candidate, BGP-15, can prevent AAPD-induced glucose, lipid, and weight changes.	aapd	132-136	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	40-58
22322357-2	2012	Here, we address the question whether a heat-shock protein (HSP) co-inducer, insulin sensitizer drug candidate, BGP-15, can prevent AAPD-induced glucose, lipid, and weight changes.	aapd	132-136	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	60-63
22322357-2	2012	Here, we address the question whether a heat-shock protein (HSP) co-inducer, insulin sensitizer drug candidate, BGP-15, can prevent AAPD-induced glucose, lipid, and weight changes.	Glucose	145-152	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	40-58
22322357-2	2012	Here, we address the question whether a heat-shock protein (HSP) co-inducer, insulin sensitizer drug candidate, BGP-15, can prevent AAPD-induced glucose, lipid, and weight changes.	Glucose	145-152	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	60-63
21732139-8	2012	PS-341-mediated cell damage could be significantly augmented by HSP inhibition.	Bortezomib	0-6	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-67
22641665-10	2012	Furthermore, it has been shown that treatment strategies combining the HSP inhibitor KNK437 or interferon-gamma (IFN-gamma) with gemcitabine, were effective in gemcitabine-resistant pancreatic cancer cells in vitro.	gemcitabine	160-171	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	71-74
22203175-8	2012	RESULTS: Serum levels of BAP was significantly lower in patients with nephrotic relapse than those in patients with nephrotic remission or HSP.	benzylaminopurine	25-28	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	139-142
21821695-2	2011	The chaperone function of HSP90 is blocked by 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), although it results in transcription and translation of antiapoptotic HSP proteins.	tanespimycin	46-86	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	26-29
22863365-6	2012	Recently, we observed that heat shock protein (HSP)-inducing drugs, such as geranylgeranylacetone, prevent derailment of proteostasis and remodeling of cardiomyocytes and thereby attenuate the AF substrate in cellular, Drosophila melanogaster, and animal experimental models.	geranylgeranylacetone	76-97	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	47-50
21964250-7	2012	Our data have suggested that 17-AAG and curcumin are effective in vitro in both rescuing the nuclear localization and transactivation activity of PHOX2B carrying the largest expansion of polyAla and promoting the clearance of aggregates of these mutant proteins inducing molecular mechanisms such as ubiquitin-proteasome (UPS), autophagy and heat shock protein (HSP) systems.	tanespimycin	29-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	342-360
21964250-7	2012	Our data have suggested that 17-AAG and curcumin are effective in vitro in both rescuing the nuclear localization and transactivation activity of PHOX2B carrying the largest expansion of polyAla and promoting the clearance of aggregates of these mutant proteins inducing molecular mechanisms such as ubiquitin-proteasome (UPS), autophagy and heat shock protein (HSP) systems.	tanespimycin	29-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	362-365
21964250-7	2012	Our data have suggested that 17-AAG and curcumin are effective in vitro in both rescuing the nuclear localization and transactivation activity of PHOX2B carrying the largest expansion of polyAla and promoting the clearance of aggregates of these mutant proteins inducing molecular mechanisms such as ubiquitin-proteasome (UPS), autophagy and heat shock protein (HSP) systems.	Curcumin	40-48	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	342-360
21964250-7	2012	Our data have suggested that 17-AAG and curcumin are effective in vitro in both rescuing the nuclear localization and transactivation activity of PHOX2B carrying the largest expansion of polyAla and promoting the clearance of aggregates of these mutant proteins inducing molecular mechanisms such as ubiquitin-proteasome (UPS), autophagy and heat shock protein (HSP) systems.	Curcumin	40-48	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	362-365
22761656-12	2012	CONCLUSION: Culture in 2% O(2) variably altered hsp expression in a panel of melanoma cell lines.	Oxygen	26-30	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	48-51
25188483-5	2011	HSP inhibitors (eg, tanespimycin) decrease MM proliferation and suppress the long-term replicative potential of MM cells; they may also sensitize MM cells to other anticancer agents.	tanespimycin	20-32	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
21821695-2	2011	The chaperone function of HSP90 is blocked by 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), although it results in transcription and translation of antiapoptotic HSP proteins.	tanespimycin	88-94	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	26-29
21821695-3	2011	Using three myeloma cell lines, we tested whether inhibition of transcription/translation of HSP or client proteins will enhance 17-AAG-mediated cytotoxicity.	tanespimycin	129-135	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	93-96
21821695-5	2011	17-AAG treatment resulted in HSP transcript and protein level elevation.	tanespimycin	0-6	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	29-32
21604275-7	2011	Solubility enhancement was due to the incorporation of drugs into Hsp-G micelle, with naringenin being more soluble than flurbiprofen.	naringenin	86-96	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	66-69
21604275-7	2011	Solubility enhancement was due to the incorporation of drugs into Hsp-G micelle, with naringenin being more soluble than flurbiprofen.	Flurbiprofen	121-133	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	66-69
21165727-1	2011	Cell Stress & Chaperones journal has become a major outlet for papers and review articles about anti-heat shock protein (HSP) antibodies.	Adenosine Monophosphate	13-16	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	125-128
22335904-1	2011	OBJECTIVE: To detect the changes of heat shock protein(HSP) expression in human hepatocellular carcinoma HepG2 cells after treated by quercetin through a proteomics strategy termed SILAC (stable isotope labeling by amino acids in cell culture)-MS (mass spectrometry).	Quercetin	134-143	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-59
21707890-5	2011	Functionally, cells expressing hSP-C(I73T) demonstrated both impaired uptake and degradation of surfactant phospholipid, thus providing a molecular mechanism for the observed lipid accumulation in patients expressing hSP-C(I73T) through the disruption of normal phospholipid recycling.	Phospholipids	107-119	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
21707890-5	2011	Functionally, cells expressing hSP-C(I73T) demonstrated both impaired uptake and degradation of surfactant phospholipid, thus providing a molecular mechanism for the observed lipid accumulation in patients expressing hSP-C(I73T) through the disruption of normal phospholipid recycling.	Phospholipids	262-274	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
21707890-5	2011	Functionally, cells expressing hSP-C(I73T) demonstrated both impaired uptake and degradation of surfactant phospholipid, thus providing a molecular mechanism for the observed lipid accumulation in patients expressing hSP-C(I73T) through the disruption of normal phospholipid recycling.	Phospholipids	262-274	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	217-220
20926391-4	2010	GSK-3beta promotes apoptosis through numerous pathways, including phosphorylation of heat shock factor 1 (HSF1) at Ser(303) (Ser(P)(303) HSF1), which inactivates HSF1 and inhibits HSP expression.	Serine	115-118	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	180-183
20926391-0	2010	O-linked beta-N-acetylglucosamine (O-GlcNAc) regulates stress-induced heat shock protein expression in a GSK-3beta-dependent manner.	o-linked beta-n-acetylglucosamine	0-33	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	70-88
20926391-0	2010	O-linked beta-N-acetylglucosamine (O-GlcNAc) regulates stress-induced heat shock protein expression in a GSK-3beta-dependent manner.	o-glcnac	35-43	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	70-88
20809860-7	2011	The HSp group had higher percentages of BOP compared to those of the chronic periodontitis and HDp groups.	bop	40-43	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	4-7
21765900-11	2011	Dividing these loci by the subsystems of dopamine synthesis, degradation/transport, receptor and modulation, we found that the modulation and receptor subsystems made the most significant contribution to HSP.	Dopamine	41-49	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	204-207
20926391-4	2010	GSK-3beta promotes apoptosis through numerous pathways, including phosphorylation of heat shock factor 1 (HSF1) at Ser(303) (Ser(P)(303) HSF1), which inactivates HSF1 and inhibits HSP expression.	Serine	125-128	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	180-183
20378850-3	2010	We have investigated whether exposure of VSMC to LDL induces changes on the proteomic profile of the heat shock protein (HSP) family-molecular chaperones involved in atherosclerosis.	vsmc	41-45	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	101-119
20724260-0	2010	Abrogating HSP response augments cell death induced by As2O3 in glioma cell lines.	Arsenic Trioxide	55-60	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	11-14
20957029-6	2010	Heat stress- and other HSP inducer (CdCl(2), celastrol, MG132)-induced HSP70 expression could be inhibited by AICAR, an AMPK specific activator.	cdcl	36-40	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	23-26
20957029-6	2010	Heat stress- and other HSP inducer (CdCl(2), celastrol, MG132)-induced HSP70 expression could be inhibited by AICAR, an AMPK specific activator.	celastrol	45-54	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	23-26
20957029-6	2010	Heat stress- and other HSP inducer (CdCl(2), celastrol, MG132)-induced HSP70 expression could be inhibited by AICAR, an AMPK specific activator.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	56-61	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	23-26
20378850-3	2010	We have investigated whether exposure of VSMC to LDL induces changes on the proteomic profile of the heat shock protein (HSP) family-molecular chaperones involved in atherosclerosis.	vsmc	41-45	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	121-124
20138231-9	2010	The availability of amphibian cultured cells has enabled the analysis of hsp gene expression induced by different stresses (e.g. cadmium, arsenite, proteasome inhibitors etc.	Cadmium	129-136	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	73-76
20450150-7	2010	As glucose only forms three hydrogen bonds with the residues Glu321, Asn323, and Glu329 by the hydroxyl groups in the C3 and C4 atoms, its interaction with hSP-D is weaker than that of mannose.	Glucose	3-10	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	156-159
20362559-9	2010	The results also are consistent with the notion that targeting HSP could be a therapeutic approach to delay the progression of aMCI to AD.	amci	127-131	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	63-66
20138231-9	2010	The availability of amphibian cultured cells has enabled the analysis of hsp gene expression induced by different stresses (e.g. cadmium, arsenite, proteasome inhibitors etc.	arsenite	138-146	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	73-76
20138484-6	2010	We found that expression levels of HSP and Bcl-2 in fibroblasts were strongly dependent on the surface hydrophilicity and concentration of nitrogen-containing functional groups on the nanofiber matrices.	Nitrogen	139-147	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	35-38
20498762-9	2010	CONCLUSIONS: It was concluded that expression of IL-10 by gingival mononuclear cells and patients" sero-reactivity to the cross-reactive HSP peptide of P. gingivalis HSP60 were significantly correlated with alveolar bone height.	sero	99-103	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	137-140
21136976-5	2009	A series of diversified proteotoxic stresses, including heat, hypoxia/ischemia, free radicals, acidosis, ATP depletion and toxins are capable of inducing a typical cellular stress response characterised by rapid inhibition of overall protein synthesis, with a concomitant dramatic increase in HSP expression.	Free Radicals	80-93	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	293-296
19837850-3	2010	Multimeric SP-D has strong antiviral activity and is a potent viral and bacterial agglutinin and opsonin; however, trimers composed of the neck and carbohydrate recognition domain (hSP-D-NCRD) of SP-D lack these activities.	Carbohydrates	148-160	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	181-184
20388101-4	2010	The mechanisms through which dietary supplementation with antioxidants may be useful to prevent free radical-related diseases is related to their ability to counteract toxic production of both reactive oxygen and nitrogen species, along with the up-regulation of vitagenes, such as members of the heat shock protein (Hsp) family heme oxygenase-1 and Hsp70.	Free Radicals	96-108	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	297-315
20388101-4	2010	The mechanisms through which dietary supplementation with antioxidants may be useful to prevent free radical-related diseases is related to their ability to counteract toxic production of both reactive oxygen and nitrogen species, along with the up-regulation of vitagenes, such as members of the heat shock protein (Hsp) family heme oxygenase-1 and Hsp70.	Free Radicals	96-108	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	317-320
19486901-0	2009	Simultaneous proteosome inhibition and heat shock protein induction by bortezomib is beneficial in experimental pancreatitis.	Bortezomib	71-81	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	39-57
19486901-3	2009	The heat shock protein (HSP) inducing effect of bortezomib is also documented.	Bortezomib	48-58	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	4-22
19486901-3	2009	The heat shock protein (HSP) inducing effect of bortezomib is also documented.	Bortezomib	48-58	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	24-27
19559024-1	2009	alphaB-crystallin, a low-molecular-weight heat shock protein (HSP), has binding sites on platelets.	alphab-crystallin	0-17	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	42-60
19559024-1	2009	alphaB-crystallin, a low-molecular-weight heat shock protein (HSP), has binding sites on platelets.	alphab-crystallin	0-17	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	62-65
19246153-3	2009	We observe that curcumin activates hsp70A and hsp70B mRNA transcription, increases HSP protein expression but decreases the expression of Bag-1, a Hsp70 co-chaperone in K562 cells.	Curcumin	16-24	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	83-86
20093746-12	2009	rhTGF-beta1 and/or CPT-11 may potentate resistance to chemotherapy by increasing HSP and MRP expression but, on the other hand, they may limit tumour cell spread by decreasing the level of some soluble mediators of inflammation (IL-6 and NO).	Irinotecan	19-25	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
21136976-5	2009	A series of diversified proteotoxic stresses, including heat, hypoxia/ischemia, free radicals, acidosis, ATP depletion and toxins are capable of inducing a typical cellular stress response characterised by rapid inhibition of overall protein synthesis, with a concomitant dramatic increase in HSP expression.	Adenosine Triphosphate	105-108	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	293-296
19265068-1	2009	The primary aim of the present study was to test the hypothesis that training with reduced carbohydrate availability from both endogenous and exogenous sources provides an enhanced stimulus for training-induced heat shock protein (HSP) adaptations of skeletal muscle.	Carbohydrates	91-103	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	211-229
19265068-1	2009	The primary aim of the present study was to test the hypothesis that training with reduced carbohydrate availability from both endogenous and exogenous sources provides an enhanced stimulus for training-induced heat shock protein (HSP) adaptations of skeletal muscle.	Carbohydrates	91-103	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	231-234
19269222-11	2009	Immunohistochemical detection of dopaminergic terminal marker deficits, glial reactions, and HSP induction might provide useful information regarding the pathophysiology of chronic and/or lethal METH use in cases of METH-related deaths, where METH intoxication may not be toxicologically demonstrated.	Methamphetamine	216-220	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	93-96
19269222-11	2009	Immunohistochemical detection of dopaminergic terminal marker deficits, glial reactions, and HSP induction might provide useful information regarding the pathophysiology of chronic and/or lethal METH use in cases of METH-related deaths, where METH intoxication may not be toxicologically demonstrated.	Methamphetamine	216-220	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	93-96
18487360-6	2008	In cultured lung explants from hSP-A(-313):hGH transgenic fetal mice, cAMP and IL-1 induced and Dex inhibited transgene expression.	Cyclic AMP	70-74	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
18781898-7	2008	A variety of agents have been found to interfere with Hsp function, mainly by binding to an ATP binding site on the molecule.	Adenosine Triphosphate	92-95	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	54-57
18487360-6	2008	In cultured lung explants from hSP-A(-313):hGH transgenic fetal mice, cAMP and IL-1 induced and Dex inhibited transgene expression.	Dexamethasone	96-99	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
18487360-8	2008	The finding that expression of the hSP-A(-313TBEmut):hGH transgene was essentially undetectable in fetal lung and was not hormonally regulated in transgenic fetal lung explants underscores the critical importance of the TBE in lung cell-specific, developmental, and hormonal regulation of hSP-A2 gene expression.	tbe	45-48	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	35-38
19080518-1	2008	OBJECTIVE: To study the expression of COP9, JAK2, HSP and NADH genes in ovarian carcinoma tissues after taxol-chemotherapy and their significance.	Paclitaxel	104-109	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	50-53
19080518-8	2008	However, HSP, JAK2 and NADH genes had significantly higher copy numbers in group 1 than in group 2 (5766, 7653, 3200 in group 1 and 3341, 3094, 1522 in group 2, respectively; all P < 0.05).	NAD	23-27	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	9-12
17681842-2	2007	In previous studies, both quercetin and KNK437 inhibited heat shock factor activity resulting in a repression of hsp mRNA and protein accumulation in human cultured cells.	Quercetin	26-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	113-116
18238941-2	2008	This study addressed the effects of geranylgeranylacetone (GGA), an orally active HSP inducer, on the atrial fibrillation (AF) substrate associated with acute atrial ischaemia (AI).	geranylgeranylacetone	36-57	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	82-85
18081892-6	2008	Because ATO is known to induce a HS-like response in a variety of cells, we investigated its ability to induce gene expression of Hsp in neutrophils and found that ATO increases HSP90AA1, HSPA1 and HSPB1 mRNA in these cells.	Arsenic Trioxide	8-11	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	130-133
18081892-6	2008	Because ATO is known to induce a HS-like response in a variety of cells, we investigated its ability to induce gene expression of Hsp in neutrophils and found that ATO increases HSP90AA1, HSPA1 and HSPB1 mRNA in these cells.	Arsenic Trioxide	164-167	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	130-133
17943263-2	2007	In this paper, we show that celastrol, a compound recently shown to up-regulate hsp gene expression, significantly decreases killing of cells expressing mutant polyglutamine protein.	celastrol	28-37	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
17943263-3	2007	This effect requires the presence of the transcription factor responsible for mediating inducible hsp gene expression, HSF1, and is correlated with decreased amounts and increased sodium dodecyl sulfate (SDS) solubility of polyglutamine aggregates.	Sodium Dodecyl Sulfate	180-202	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	98-101
17943263-3	2007	This effect requires the presence of the transcription factor responsible for mediating inducible hsp gene expression, HSF1, and is correlated with decreased amounts and increased sodium dodecyl sulfate (SDS) solubility of polyglutamine aggregates.	Sodium Dodecyl Sulfate	204-207	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	98-101
17943263-3	2007	This effect requires the presence of the transcription factor responsible for mediating inducible hsp gene expression, HSF1, and is correlated with decreased amounts and increased sodium dodecyl sulfate (SDS) solubility of polyglutamine aggregates.	polyglutamine	223-236	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	98-101
17681842-3	2007	In this first study of the effect of these hsp gene expression inhibitors in a non-mammalian cell line, we report that both quercetin and KNK437 reduced the heat shock-induced accumulation of hsp30, hsp47 and hsp70 mRNA in X. laevis cultured cells.	Quercetin	124-133	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-46
17952766-0	2007	Identification of genes responsive to paeoniflorin, a heat shock protein-inducing compound, in human leukemia U937 cells.	peoniflorin	38-50	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	54-72
17923264-6	2007	CONCLUSIONS: We postulate that higher ADMA levels are associated with excessive levels of oxidative damage and stress markers (HSP, LOX-1) in placental tissues.	N,N-dimethylarginine	38-42	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	127-130
17567739-5	2007	Cross-linked Hsp21-Hsp21 dipeptides indicated an exposure of the Hsp21 C-terminal tails and substrate-binding sites normally covered by the C terminus.	Dipeptides	25-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	13-16
17512992-7	2007	Moreover, lithium was found to down-regulate genes coding for anti-apoptotic gene BAG-1 and for most of the molecular chaperones (HSP, GRP).	Lithium	10-17	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	130-133
17292409-1	2007	BACKGROUND: Glutamine (GLN) has been shown to confer cytoprotection by enhancing endogenous heat shock protein (HSP) expression.	Glutamine	12-21	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	92-110
17292409-1	2007	BACKGROUND: Glutamine (GLN) has been shown to confer cytoprotection by enhancing endogenous heat shock protein (HSP) expression.	Glutamine	12-21	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	112-115
17292409-1	2007	BACKGROUND: Glutamine (GLN) has been shown to confer cytoprotection by enhancing endogenous heat shock protein (HSP) expression.	Glutamine	23-26	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	92-110
17292409-1	2007	BACKGROUND: Glutamine (GLN) has been shown to confer cytoprotection by enhancing endogenous heat shock protein (HSP) expression.	Glutamine	23-26	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	112-115
17143995-0	2006	Azathioprine and tubulointerstitial nephritis in HSP.	Azathioprine	0-12	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
17496388-5	2007	The prevalence of the FMF gene in Middle Eastern countries raises interesting questions regarding the use of colchicine in HSP patients.	Colchicine	109-119	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	123-126
17395183-0	2007	Heat shock protein 27 is associated with irinotecan resistance in human colorectal cancer cells.	Irinotecan	41-51	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-18
17395183-2	2007	In the present study, we investigated the influence of Hsp expression on the irinotecan resistance of human colorectal cancer cells.	Irinotecan	77-87	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	55-58
17395183-3	2007	Among eight Hsp genes tested in this study, we confirmed that the expression of Hsp27 correlated with irinotecan resistance in colorectal cancer cells.	Irinotecan	102-112	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-15
17182004-0	2007	The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer).	geranylgeranylacetone	82-103	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	51-54
17210450-8	2007	Additionally, pretreatment of ALCAR and LA also led to elevated cellular GSH and heat shock protein (HSP) levels compared to untreated control cells.	Acetylcarnitine	30-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-99
17210450-8	2007	Additionally, pretreatment of ALCAR and LA also led to elevated cellular GSH and heat shock protein (HSP) levels compared to untreated control cells.	Acetylcarnitine	30-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	101-104
17110598-5	2006	These reductions were prevented by HSP-inducing pretreatments: mild heat shock, geranylgeranylacetone (GGA), and transfection with human HSP27 or the phosphorylation-mimicking HSP27-DDD.	geranylgeranylacetone	80-101	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	35-38
17009592-4	2006	The results indicated that a group of heat shock protein (hsp) genes were upregulated by 3 mM NaB within the first 24 hours of exposure.	nab	94-97	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	38-56
17172411-7	2006	Mechanistically, TS protein was found to interact with heat shock protein (Hsp) complex, and trichostatin A treatment induced chaperonic Hsp90 acetylation and subsequently enhanced Hsp70 binding to TS, which led to the proteasomal degradation of TS protein.	trichostatin A	93-107	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	55-73
17172411-7	2006	Mechanistically, TS protein was found to interact with heat shock protein (Hsp) complex, and trichostatin A treatment induced chaperonic Hsp90 acetylation and subsequently enhanced Hsp70 binding to TS, which led to the proteasomal degradation of TS protein.	trichostatin A	93-107	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-78
17009592-4	2006	The results indicated that a group of heat shock protein (hsp) genes were upregulated by 3 mM NaB within the first 24 hours of exposure.	nab	94-97	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	58-61
17009592-5	2006	Because the transcription of hsp genes is under the control of heat shock factors (HSFs), we measured the effects of overexpressed HSF-1 on the responses of HT 29 cells to NaB.	nab	172-175	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	29-32
16718369-3	2006	The GSH- and Hsp-enhancing effects were accompanied by a parallel cytoprotection against xanthine oxidase/xanthine-induced toxicity, with the biphasic time course of (+)Sch B- or (-)Sch B-induced protection being superimposed with that of the increase in GSH level but not Hsp25/70 production.	Xanthine	89-97	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	13-16
16718369-3	2006	The GSH- and Hsp-enhancing effects were accompanied by a parallel cytoprotection against xanthine oxidase/xanthine-induced toxicity, with the biphasic time course of (+)Sch B- or (-)Sch B-induced protection being superimposed with that of the increase in GSH level but not Hsp25/70 production.	sch b	169-174	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	13-16
16718369-3	2006	The GSH- and Hsp-enhancing effects were accompanied by a parallel cytoprotection against xanthine oxidase/xanthine-induced toxicity, with the biphasic time course of (+)Sch B- or (-)Sch B-induced protection being superimposed with that of the increase in GSH level but not Hsp25/70 production.	sch b	182-187	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	13-16
16718369-3	2006	The GSH- and Hsp-enhancing effects were accompanied by a parallel cytoprotection against xanthine oxidase/xanthine-induced toxicity, with the biphasic time course of (+)Sch B- or (-)Sch B-induced protection being superimposed with that of the increase in GSH level but not Hsp25/70 production.	Glutathione	255-258	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	13-16
16718369-4	2006	The results indicate that (-)Sch B produces more potent enhancing effects on cellular GSH and Hsp production as well as protection against oxidative injury than (+)Sch B in cardiomyocytes.	sch b	29-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	94-97
16595161-0	2006	Metal ions induced heat shock protein response by elevating superoxide anion level in HeLa cells transformed by HSE-SEAP reporter gene.	Metals	0-5	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	19-37
16966184-1	2006	PURPOSE: We examined the effects of a heat shock protein (hsp) inhibitor, N-formyl-3, 4-methylenedioxy-gamma-butyrolactam (KNK437), on the radiosensitivity of human glioblastoma cells (A-172).	n-formyl-3, 4-methylenedioxy-gamma-butyrolactam	74-121	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	38-56
16966184-1	2006	PURPOSE: We examined the effects of a heat shock protein (hsp) inhibitor, N-formyl-3, 4-methylenedioxy-gamma-butyrolactam (KNK437), on the radiosensitivity of human glioblastoma cells (A-172).	n-formyl-3, 4-methylenedioxy-gamma-butyrolactam	74-121	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	58-61
16595161-0	2006	Metal ions induced heat shock protein response by elevating superoxide anion level in HeLa cells transformed by HSE-SEAP reporter gene.	Superoxides	60-76	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	19-37
16595161-1	2006	The aim of this work is to define the relationship between heat shock protein (HSP) and reactive oxygen species (ROS) in the cells exposed to different concentrations of metal ions, and to evaluate a new method for tracing the dynamic levels of cellular reactive oxygen species using a HSE-SEAP reporter gene.	Reactive Oxygen Species	88-111	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	59-77
16595161-1	2006	The aim of this work is to define the relationship between heat shock protein (HSP) and reactive oxygen species (ROS) in the cells exposed to different concentrations of metal ions, and to evaluate a new method for tracing the dynamic levels of cellular reactive oxygen species using a HSE-SEAP reporter gene.	Reactive Oxygen Species	88-111	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	79-82
16595161-1	2006	The aim of this work is to define the relationship between heat shock protein (HSP) and reactive oxygen species (ROS) in the cells exposed to different concentrations of metal ions, and to evaluate a new method for tracing the dynamic levels of cellular reactive oxygen species using a HSE-SEAP reporter gene.	Reactive Oxygen Species	113-116	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	59-77
16595161-1	2006	The aim of this work is to define the relationship between heat shock protein (HSP) and reactive oxygen species (ROS) in the cells exposed to different concentrations of metal ions, and to evaluate a new method for tracing the dynamic levels of cellular reactive oxygen species using a HSE-SEAP reporter gene.	Reactive Oxygen Species	113-116	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	79-82
16595161-1	2006	The aim of this work is to define the relationship between heat shock protein (HSP) and reactive oxygen species (ROS) in the cells exposed to different concentrations of metal ions, and to evaluate a new method for tracing the dynamic levels of cellular reactive oxygen species using a HSE-SEAP reporter gene.	Metals	170-175	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	59-77
16595161-1	2006	The aim of this work is to define the relationship between heat shock protein (HSP) and reactive oxygen species (ROS) in the cells exposed to different concentrations of metal ions, and to evaluate a new method for tracing the dynamic levels of cellular reactive oxygen species using a HSE-SEAP reporter gene.	Metals	170-175	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	79-82
16595161-1	2006	The aim of this work is to define the relationship between heat shock protein (HSP) and reactive oxygen species (ROS) in the cells exposed to different concentrations of metal ions, and to evaluate a new method for tracing the dynamic levels of cellular reactive oxygen species using a HSE-SEAP reporter gene.	Reactive Oxygen Species	254-277	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	59-77
16595161-1	2006	The aim of this work is to define the relationship between heat shock protein (HSP) and reactive oxygen species (ROS) in the cells exposed to different concentrations of metal ions, and to evaluate a new method for tracing the dynamic levels of cellular reactive oxygen species using a HSE-SEAP reporter gene.	Reactive Oxygen Species	254-277	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	79-82
16595161-2	2006	The expression of heat shock protein was measured using a secreted alkaline phosphatase (SEAP) reporter gene transformed into HeLa cell strain, the levels of superoxide anion (O(2)(-)) and hydrogen peroxide (H(2)O(2)) were determined by NBT reduction assay and DCFH staining flow cytometry (FCM), respectively.	Superoxides	158-174	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-36
16595161-2	2006	The expression of heat shock protein was measured using a secreted alkaline phosphatase (SEAP) reporter gene transformed into HeLa cell strain, the levels of superoxide anion (O(2)(-)) and hydrogen peroxide (H(2)O(2)) were determined by NBT reduction assay and DCFH staining flow cytometry (FCM), respectively.	Hydrogen Peroxide	189-206	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-36
16595161-2	2006	The expression of heat shock protein was measured using a secreted alkaline phosphatase (SEAP) reporter gene transformed into HeLa cell strain, the levels of superoxide anion (O(2)(-)) and hydrogen peroxide (H(2)O(2)) were determined by NBT reduction assay and DCFH staining flow cytometry (FCM), respectively.	Nitroblue Tetrazolium	237-240	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-36
16595161-2	2006	The expression of heat shock protein was measured using a secreted alkaline phosphatase (SEAP) reporter gene transformed into HeLa cell strain, the levels of superoxide anion (O(2)(-)) and hydrogen peroxide (H(2)O(2)) were determined by NBT reduction assay and DCFH staining flow cytometry (FCM), respectively.	DCFH	261-265	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-36
16595161-3	2006	The experimental results demonstrated that the expression of heat shock protein induced by metal ions was linearly related to the cellular superoxide anion level before cytotoxic effects were observed, but not related to the cellular hydrogen peroxide level.	Metals	91-96	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	61-79
16595161-3	2006	The experimental results demonstrated that the expression of heat shock protein induced by metal ions was linearly related to the cellular superoxide anion level before cytotoxic effects were observed, but not related to the cellular hydrogen peroxide level.	Superoxides	139-155	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	61-79
16595161-3	2006	The experimental results demonstrated that the expression of heat shock protein induced by metal ions was linearly related to the cellular superoxide anion level before cytotoxic effects were observed, but not related to the cellular hydrogen peroxide level.	Hydrogen Peroxide	234-251	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	61-79
16595161-4	2006	The experimental results suggested that metal ions might induce heat shock protein by elevating cellular superoxide anion level, and thus the expression of heat shock protein indicated by the HSE-SEAP reporter gene can be an effective model for monitoring the dynamic level of superoxide anion and early metal-induced oxidative stress/cytotoxicity.	Metals	40-45	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-82
16595161-4	2006	The experimental results suggested that metal ions might induce heat shock protein by elevating cellular superoxide anion level, and thus the expression of heat shock protein indicated by the HSE-SEAP reporter gene can be an effective model for monitoring the dynamic level of superoxide anion and early metal-induced oxidative stress/cytotoxicity.	Metals	40-45	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	156-174
16595161-4	2006	The experimental results suggested that metal ions might induce heat shock protein by elevating cellular superoxide anion level, and thus the expression of heat shock protein indicated by the HSE-SEAP reporter gene can be an effective model for monitoring the dynamic level of superoxide anion and early metal-induced oxidative stress/cytotoxicity.	Superoxides	105-121	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-82
16595161-4	2006	The experimental results suggested that metal ions might induce heat shock protein by elevating cellular superoxide anion level, and thus the expression of heat shock protein indicated by the HSE-SEAP reporter gene can be an effective model for monitoring the dynamic level of superoxide anion and early metal-induced oxidative stress/cytotoxicity.	Superoxides	105-121	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	156-174
16595161-4	2006	The experimental results suggested that metal ions might induce heat shock protein by elevating cellular superoxide anion level, and thus the expression of heat shock protein indicated by the HSE-SEAP reporter gene can be an effective model for monitoring the dynamic level of superoxide anion and early metal-induced oxidative stress/cytotoxicity.	Superoxides	277-293	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-82
16595161-4	2006	The experimental results suggested that metal ions might induce heat shock protein by elevating cellular superoxide anion level, and thus the expression of heat shock protein indicated by the HSE-SEAP reporter gene can be an effective model for monitoring the dynamic level of superoxide anion and early metal-induced oxidative stress/cytotoxicity.	Superoxides	277-293	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	156-174
16595161-4	2006	The experimental results suggested that metal ions might induce heat shock protein by elevating cellular superoxide anion level, and thus the expression of heat shock protein indicated by the HSE-SEAP reporter gene can be an effective model for monitoring the dynamic level of superoxide anion and early metal-induced oxidative stress/cytotoxicity.	Metals	304-309	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	156-174
16579653-3	2006	The heat preconditioning transiently up-regulated the Hsp levels in Hsf1 wild-type cells and significantly improved their postirradiation survival; these effects could be abolished by quercetin or simulated (without preheating) by the Hsf1 overexpression.	Quercetin	184-193	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	54-57
16550610-4	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the HSP90 inhibitor 17-AAG would potentiate ZD 1839-mediated glioma cytotoxicity by decreasing the activation status of EGF receptor, as well as down regulating the levels of other relevant signaling effectors.	Gefitinib	238-245	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-30
16550610-4	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the HSP90 inhibitor 17-AAG would potentiate ZD 1839-mediated glioma cytotoxicity by decreasing the activation status of EGF receptor, as well as down regulating the levels of other relevant signaling effectors.	Gefitinib	238-245	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	32-35
16420102-5	2006	Using human colorectal carcinoma and hepatoma cell lines in vitro, we showed that TPPS(2a)-based photochemical treatment enhances expression of cellular HSP70, which correlated with a photochemically enhanced expression (approximately 2-fold, at PCI-optimal doses) of the HSPp-controlled transgene integrated in the genome.	tetraphenylporphine sulfonate	82-86	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	272-276
16749714-3	2006	On average, it was found that mesophilic incubation had the most significant positive effect on PH followed by treatment with Ac, although the units with the best performance (high values of PH, initial hydrogen production rate, and short lag time) were those HSP-induced units incubated at 37 degrees C (type of inocula was not significant).	Actinium	126-128	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	260-263
16464956-0	2006	HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.	Proline	68-75	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
16464956-0	2006	HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.	Serine	85-88	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
16464956-0	2006	HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.	Threonine	89-92	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
16677090-0	2006	Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity.	Nitric Oxide	73-85	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	20-38
16677090-0	2006	Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity.	Carbon Monoxide	90-105	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	20-38
16278218-5	2006	We show that activation of HSF1 to bind HSE in hsp promoters is inhibited through the phosphorylation of a specific residue, serine 121 by MK2.	Serine	125-131	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	47-50
16452615-3	2006	Crystallographic studies have shown that EEVD interacts with positively charged amino acids in Hop TPR-binding pockets (called carboxylate clamps), and point mutations of these carboxylate clamp positions can disrupt Hsp binding.	carboxylate	127-138	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	217-220
16452615-3	2006	Crystallographic studies have shown that EEVD interacts with positively charged amino acids in Hop TPR-binding pockets (called carboxylate clamps), and point mutations of these carboxylate clamp positions can disrupt Hsp binding.	carboxylate	177-188	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	217-220
16521214-7	2006	Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA.	ursolic acid	161-163	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	71-89
16521214-7	2006	Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA.	ursolic acid	161-163	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	91-94
16533928-2	2005	Initiating insults, such as elevated or depressed temperature, diminished oxygen, and pressure, increase HSP expression and can protect cells against subsequent, otherwise lethal, insults.	Oxygen	74-80	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	105-108
16267832-3	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the combination of the PI3K inhibitor LY294002 and the HSP90 inhibitor 17-allyl-aminogeldanamycin (17-AAG) would promote glioma cytotoxicity by decreasing both the activation status and levels of Akt, as well as downregulating the levels of other relevant signaling effectors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	232-240	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-30
16267832-3	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the combination of the PI3K inhibitor LY294002 and the HSP90 inhibitor 17-allyl-aminogeldanamycin (17-AAG) would promote glioma cytotoxicity by decreasing both the activation status and levels of Akt, as well as downregulating the levels of other relevant signaling effectors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	232-240	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	32-35
16267832-3	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the combination of the PI3K inhibitor LY294002 and the HSP90 inhibitor 17-allyl-aminogeldanamycin (17-AAG) would promote glioma cytotoxicity by decreasing both the activation status and levels of Akt, as well as downregulating the levels of other relevant signaling effectors.	tanespimycin	265-291	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-30
16267832-3	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the combination of the PI3K inhibitor LY294002 and the HSP90 inhibitor 17-allyl-aminogeldanamycin (17-AAG) would promote glioma cytotoxicity by decreasing both the activation status and levels of Akt, as well as downregulating the levels of other relevant signaling effectors.	tanespimycin	265-291	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	32-35
16267832-3	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the combination of the PI3K inhibitor LY294002 and the HSP90 inhibitor 17-allyl-aminogeldanamycin (17-AAG) would promote glioma cytotoxicity by decreasing both the activation status and levels of Akt, as well as downregulating the levels of other relevant signaling effectors.	tanespimycin	293-299	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-30
16267832-3	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the combination of the PI3K inhibitor LY294002 and the HSP90 inhibitor 17-allyl-aminogeldanamycin (17-AAG) would promote glioma cytotoxicity by decreasing both the activation status and levels of Akt, as well as downregulating the levels of other relevant signaling effectors.	tanespimycin	293-299	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	32-35
16184764-5	2005	In contrast, in the absence of heat shock, ectoine was unable to induce hsp70B" but had the ability to induce another member of the Hsp family, the hsp70.	ectoine	43-50	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	132-135
15778495-7	2005	Compared with controls, EGFP/hSP-CDeltaexon4 promoted upregulation of multiple ER stress species, activated caspase 3, and induced annexin V binding.	cdeltaexon4	33-44	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	29-32
15898705-8	2005	To our knowledge, taraxasteryl acetate is the first natural product for which a dual effect on the hsp response is reported.	taraxasteryl acetate	18-38	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	99-102
15845487-7	2005	Using hSP-A-coupled Sepharose affinity chromatography and polyacrylamide gel electrophoresis, we identified a 65-kDa hSP-A binding protein of M. pneumoniae.	Sepharose	20-29	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	6-9
15845487-7	2005	Using hSP-A-coupled Sepharose affinity chromatography and polyacrylamide gel electrophoresis, we identified a 65-kDa hSP-A binding protein of M. pneumoniae.	Sepharose	20-29	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	117-120
15845487-7	2005	Using hSP-A-coupled Sepharose affinity chromatography and polyacrylamide gel electrophoresis, we identified a 65-kDa hSP-A binding protein of M. pneumoniae.	polyacrylamide	58-72	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	117-120
15603555-3	2005	Using biotin-labelled derivatives of epolactaene/ETB, human Hsp (heat-shock protein) 60 was identified as a binding protein of epolactaene/ETB in vitro as well as in situ.	Biotin	6-12	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	60-63
15603555-3	2005	Using biotin-labelled derivatives of epolactaene/ETB, human Hsp (heat-shock protein) 60 was identified as a binding protein of epolactaene/ETB in vitro as well as in situ.	epolactaene	37-48	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	60-63
15603555-3	2005	Using biotin-labelled derivatives of epolactaene/ETB, human Hsp (heat-shock protein) 60 was identified as a binding protein of epolactaene/ETB in vitro as well as in situ.	etb	49-52	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	60-63
15603555-3	2005	Using biotin-labelled derivatives of epolactaene/ETB, human Hsp (heat-shock protein) 60 was identified as a binding protein of epolactaene/ETB in vitro as well as in situ.	epolactaene	127-138	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	60-63
15603555-3	2005	Using biotin-labelled derivatives of epolactaene/ETB, human Hsp (heat-shock protein) 60 was identified as a binding protein of epolactaene/ETB in vitro as well as in situ.	etb	139-142	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	60-63
15557112-3	2005	We describe a full-term infant with respiratory insufficiency associated with a spontaneous heterozygous mutation resulting in a substitution of lysine for glutamic acid at position 66 (= E66K) of the proximal hSP-C COOH flanking propeptide.	Carbonic Acid	216-220	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	210-213
15706092-11	2005	Overall results suggest that activation of NF-kappaB and Hsp could allow cell adaptation and survival under exhaustive GSH depletion.	Glutathione	119-122	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	57-60
15654365-1	2005	The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.	Doxorubicin	20-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	161-179
15654365-1	2005	The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.	Doxorubicin	20-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	181-184
15557112-3	2005	We describe a full-term infant with respiratory insufficiency associated with a spontaneous heterozygous mutation resulting in a substitution of lysine for glutamic acid at position 66 (= E66K) of the proximal hSP-C COOH flanking propeptide.	propeptide	230-240	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	210-213
15583868-1	2004	BRX-235 (Iroxanadine), a novel drug developed by Biorex (Hungary), was previously characterized as a vasculoprotector against atherosclerosis, an activator of p38 kinase, and an enhancer of stress-responsive heat shock protein (Hsp) expression.	iroxanadine	0-7	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	208-226
15583868-1	2004	BRX-235 (Iroxanadine), a novel drug developed by Biorex (Hungary), was previously characterized as a vasculoprotector against atherosclerosis, an activator of p38 kinase, and an enhancer of stress-responsive heat shock protein (Hsp) expression.	iroxanadine	0-7	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	228-231
15583868-1	2004	BRX-235 (Iroxanadine), a novel drug developed by Biorex (Hungary), was previously characterized as a vasculoprotector against atherosclerosis, an activator of p38 kinase, and an enhancer of stress-responsive heat shock protein (Hsp) expression.	iroxanadine	9-20	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	208-226
15583868-1	2004	BRX-235 (Iroxanadine), a novel drug developed by Biorex (Hungary), was previously characterized as a vasculoprotector against atherosclerosis, an activator of p38 kinase, and an enhancer of stress-responsive heat shock protein (Hsp) expression.	iroxanadine	9-20	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	228-231
15370972-1	2004	PURPOSE: The effects of a heat shock protein (hsp) inhibitor KNK437 (N-formyl-3,4-methylenedioxy-benzylidene-gamma-butyrolactam) were examined on the heat sensitivity and heat tolerance of human cancer cells with special reference to p53 status.	KNK 437	61-67	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	46-49
15572040-3	2004	alphaB-Crystallin (CryAB) is the most abundant small heat shock protein (HSP) in the heart.	alphab-crystallin	0-17	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	53-71
15572040-3	2004	alphaB-Crystallin (CryAB) is the most abundant small heat shock protein (HSP) in the heart.	alphab-crystallin	0-17	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	73-76
15265933-3	2004	CD8(+) T cell recognition of the HSP/peptide complex, but not the peptide alone, was inhibited by brefeldin A, suggesting an endoplasmic reticulum-dependent pathway.	Brefeldin A	98-109	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	33-36
15128298-6	2004	The coding sequences were expressed in Escherichia coli as six-histidine tagged recombinant proteins and generated products with molecular masses of 86.1 kDa for HSP and 22.4 kDa for MnSOD.	Histidine	63-72	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	162-165
15308853-1	2004	We evaluated DNA protection effect of heat shock protein (HSP) against cytotoxic effects of exogenous nitric oxide (NO) and reactive oxygen intermediate (ROI).	Nitric Oxide	102-114	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	38-56
15308853-1	2004	We evaluated DNA protection effect of heat shock protein (HSP) against cytotoxic effects of exogenous nitric oxide (NO) and reactive oxygen intermediate (ROI).	reactive oxygen	124-139	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	38-56
15308853-1	2004	We evaluated DNA protection effect of heat shock protein (HSP) against cytotoxic effects of exogenous nitric oxide (NO) and reactive oxygen intermediate (ROI).	reactive oxygen	124-139	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	58-61
15360086-8	2004	CONCLUSIONS: The Hsp90 chaperone complex inhibitor, radicicol, potentiated heat-induced cellular killing, and inhibition of p42/p44 Erk and Akt activation rather than modification of Hsp expression might be involved in enhancing cellular thermosensitivity.	monorden	52-61	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	17-20
15070600-9	2004	In vitro HT29 culture cells subjected to a heated water bath exhibited a cellular sensitivity to heat and change of HSP expression similar to those in tumor xenografts subjected to RFA.	Water	50-55	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	116-119
15100266-5	2004	Inhibition of cytosolic processing mechanisms (e.g., by transporter for Ag presentation deficiency or brefeldin A) blocked HSP-enhanced peptide presentation in dendritic cells but not macrophages.	Brefeldin A	102-113	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	123-126
14676650-12	2003	In in vitro studies, PMNLs from 10 healthy volunteers were incubated at 37 degrees C, 34 degrees C, or 26 degrees C for 1 hour with sodium arsenite (100 micromol/L), an HSP inducer.	sodium arsenite	132-147	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	169-172
15633297-14	2004	In conclusion, maintaining glucose availability during exercise attenuates the circulating Hsp response in healthy humans.	Glucose	27-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	91-94
15633296-6	2004	Glycyrrhizin had an enhancing effect on the HSP induction by heat shock but could not induce HSPs by itself.	Glycyrrhizic Acid	0-12	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	44-47
15633296-7	2004	In contrast, paeoniflorin had not only an enhancing effect but also an inducing effect by itself on HSP expression.	peoniflorin	13-25	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	100-103
14674679-11	2003	On the other hand, butyrate-responsive stress-related genes include some of the members of heat shock protein (HSP), glutathione-s-transferase (GST), glutathione peroxidase (GSH-PXs) and cytochrome P450 (CYP) families.	Butyrates	19-27	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	91-109
14674679-11	2003	On the other hand, butyrate-responsive stress-related genes include some of the members of heat shock protein (HSP), glutathione-s-transferase (GST), glutathione peroxidase (GSH-PXs) and cytochrome P450 (CYP) families.	Butyrates	19-27	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	111-114
12899704-0	2003	Identification of sodium salicylate as an hsp inducer using a simple screening system for stress response modulators in mammalian cells.	Sodium Salicylate	18-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	42-45
14625852-6	2003	Since HSP70 plays an important role in protecting cells under stress, we treated the 2774 cells with the HSP inhibitor quercetin in combination with FTI.	Quercetin	119-128	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	6-9
12803546-6	2003	Amlexanox suppressed C-terminal chaperone activity in vitro, but not N-terminal chaperone activity, and inhibited the association of cohort proteins, such as cyclophilin 40 and Hsp-organizing protein, to the C-terminal domain of Hsp90.	amlexanox	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	177-180
12899704-3	2003	Using these cells, we examined the effect of sodium salicylate (SA), which may induce the transcription of hsp genes, on stress response in mammalian cells.	Sodium Salicylate	45-62	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	107-110
12899704-3	2003	Using these cells, we examined the effect of sodium salicylate (SA), which may induce the transcription of hsp genes, on stress response in mammalian cells.	Salicylates	64-66	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	107-110
12899704-7	2003	These findings suggested that SA is a potent hsp inducer, and may be used to protect cells against deleterious stressors.	Salicylates	30-32	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	45-48
12750378-6	2003	FL overexpression prevented geldanamycin-mediated loss of total and phospho-Akt and other Hsp client proteins.	geldanamycin	28-40	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	90-93
12946265-2	2003	We demonstrated earlier that nitric oxide (NO) plays an important role in adaptive defense of the organism, in particular due to activation of heat shock protein (HSP) synthesis.	Nitric Oxide	29-41	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	143-161
12853125-7	2003	Using real time RT-PCR, we have shown that HSP and SRF mRNA were both regulated by genistein in a time- and dose-dependent manner; however, it appears that only the effect of genistein on SRF mRNA, but not HSP mRNA expression, can be partially abolished by cotreatment with estrogen antagonist ICI 182,780.	Genistein	83-92	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-46
12946265-2	2003	We demonstrated earlier that nitric oxide (NO) plays an important role in adaptive defense of the organism, in particular due to activation of heat shock protein (HSP) synthesis.	Nitric Oxide	29-41	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	163-166
12815164-2	2003	Cyclopentenone prostaglandins (cyPG) are able to activate HSF1 and induce the synthesis of the 70-kDa hsp (hsp70) in mammalian cells.	cyclopentenone	0-14	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	102-105
12815164-2	2003	Cyclopentenone prostaglandins (cyPG) are able to activate HSF1 and induce the synthesis of the 70-kDa hsp (hsp70) in mammalian cells.	Prostaglandins	15-29	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	102-105
12967786-7	2003	The early timing effect of deoxyspergualin suggests a crucial limitation to induction of stable tolerance is activation of Hsp-dependent innate responses to damage by ischemia-reperfusion.	gusperimus	27-42	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	123-126
12763290-1	2003	BACKGROUND: Heat shock protein (HSP) expression can be induced by any stress such as with adrenocorticotropic hormones and catecholamines.	Catecholamines	123-137	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-30
12763290-1	2003	BACKGROUND: Heat shock protein (HSP) expression can be induced by any stress such as with adrenocorticotropic hormones and catecholamines.	Catecholamines	123-137	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	32-35
12692182-3	2003	Our hypothesis was that an elevation of tissue vitamin C content would reduce oxidant-induced expression of protective enzymes and HSP content.	Ascorbic Acid	47-56	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	131-134
12776812-11	2003	CONCLUSIONS: Our case and the previous case suggest that HSP may represent a potential adverse effect of clarithromycin, clinicians should be alerted to this potentially severe side effect of such a widely used drug.	Clarithromycin	105-119	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	57-60
12014635-0	2002	Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor.	manumycin	115-124	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	24-42
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Heme	76-80	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-54
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Heme	76-80	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	56-59
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Biliverdine	84-94	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-54
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Biliverdine	84-94	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	56-59
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Iron	101-105	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-54
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Iron	101-105	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	56-59
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Carbon Monoxide	110-125	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-54
12935634-1	2003	Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain.	Carbon Monoxide	110-125	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	56-59
12600944-1	2003	The activation of eukaryotic heat shock protein (Hsp) gene expression occurs in response to a wide variety of cellular stresses including heat shock, hydrogen peroxide, uncoupled oxidative phosphorylation, infection, and inflammation.	Hydrogen Peroxide	150-167	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	29-47
12600944-1	2003	The activation of eukaryotic heat shock protein (Hsp) gene expression occurs in response to a wide variety of cellular stresses including heat shock, hydrogen peroxide, uncoupled oxidative phosphorylation, infection, and inflammation.	Hydrogen Peroxide	150-167	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
12600944-7	2003	HSF1 derivatives in which either or both cysteines were mutated are defective in stress-inducible trimerization and DNA binding, stress-inducible nuclear translocation and Hsp gene trans-activation, and in the protection of mouse cells from stress-induced apoptosis.	Cysteine	41-50	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	172-175
12600944-8	2003	This redox-dependent activation of HSF1 by heat and hydrogen peroxide establishes a common mechanism in the stress activation of Hsp gene expression by mammalian HSF1.	Hydrogen Peroxide	52-69	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	129-132
12700282-1	2003	This study tests the hypothesis that lowering intracellular pH (pHi) in melanoma cells grown at low extracellular pH (pHe) selectively abrogates 42 degrees C-induced heat shock protein (HSP) expression and reduces survival.	Phenylalanine	118-121	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	166-184
12700282-1	2003	This study tests the hypothesis that lowering intracellular pH (pHi) in melanoma cells grown at low extracellular pH (pHe) selectively abrogates 42 degrees C-induced heat shock protein (HSP) expression and reduces survival.	Phenylalanine	118-121	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	186-189
11960322-0	2002	Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.	geldanamycin	52-64	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
11882394-5	2002	Many researchers have found that glutamine (GLN), a conditionally essential amino acid, can enhance stress-induced HSP expression in vitro and improve cell survival against a variety of stressful stimuli.	Glutamine	33-42	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	115-118
11882394-5	2002	Many researchers have found that glutamine (GLN), a conditionally essential amino acid, can enhance stress-induced HSP expression in vitro and improve cell survival against a variety of stressful stimuli.	Glutamine	44-47	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	115-118
11882394-5	2002	Many researchers have found that glutamine (GLN), a conditionally essential amino acid, can enhance stress-induced HSP expression in vitro and improve cell survival against a variety of stressful stimuli.	Amino Acids, Essential	66-86	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	115-118
11882394-6	2002	Further, recent data from me and my colleagues indicate that a single dose of intravenous GLN can enhance HSP expression, decrease end-organ injury, and enhance survival from septic shock in the intact rat.	Glutamine	90-93	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	106-109
11882394-7	2002	Thus GLN, which is beneficial in many settings of critical illness and injury, may be a clinically applicable enhancer of HSP expression.	Glutamine	5-8	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	122-125
11882394-8	2002	These results indicate that GLN could be used to enhance HSP expression and attenuate end-organ injury in situations when a major clinical stress is anticipated, such as before major surgical procedures (e.g., cardiac, vascular, and transplantation) or in the critically ill.	Glutamine	28-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	57-60
11720291-3	2001	As a new putative function, we have previously shown that mammalian Hsp/Hsc70 as well as a distant relative, Hsp110, selectively bind certain RNA sequences via their N-terminal ATP-binding domain.	Adenosine Triphosphate	177-180	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	68-71
11692211-5	2001	Immunohistochemical demonstration of HSP expression was performed using specific monoclonal antibodies after wet autoclave antigen retrieval on sections from either Carnoy-fixed (biopsies) or formalin-fixed (transplant nephrectomies) and paraffin-embedded tissue.	Formaldehyde	192-200	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	37-40
11684453-2	2001	Hsp-inducing stress factors include elevated temperatures, alcohol, heavy metals, oxidants, and agents leading to protein denaturation.	Alcohols	59-66	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
11692211-5	2001	Immunohistochemical demonstration of HSP expression was performed using specific monoclonal antibodies after wet autoclave antigen retrieval on sections from either Carnoy-fixed (biopsies) or formalin-fixed (transplant nephrectomies) and paraffin-embedded tissue.	Paraffin	238-246	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	37-40
11448133-1	2001	Prostaglandins of the A-type (PGAs) induce heat shock protein (HSP) synthesis in a wide variety of mammalian cells resulting in protection against cellular stresses.	Prostaglandins	0-14	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-61
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Flavonoids	19-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-78
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Quercetin	32-41	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-78
11448133-1	2001	Prostaglandins of the A-type (PGAs) induce heat shock protein (HSP) synthesis in a wide variety of mammalian cells resulting in protection against cellular stresses.	Prostaglandins	0-14	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	63-66
11448133-1	2001	Prostaglandins of the A-type (PGAs) induce heat shock protein (HSP) synthesis in a wide variety of mammalian cells resulting in protection against cellular stresses.	Prostaglandins A	30-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-61
11448133-1	2001	Prostaglandins of the A-type (PGAs) induce heat shock protein (HSP) synthesis in a wide variety of mammalian cells resulting in protection against cellular stresses.	Prostaglandins A	30-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	63-66
11448133-2	2001	The effect of PGAs on HSP-induction in cardiac myocytes is unknown.	Prostaglandins A	14-18	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	22-25
11448133-3	2001	Therefore, we investigated the effect of PGA1 on HSP synthesis in adult rat cardiac myocytes.	prostaglandin A1	41-45	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
11684820-0	2001	Limited heat-shock protein 72 induction in Caco-2 cells by L-glutamine.	Glutamine	59-70	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	8-26
11484067-0	2001	Multilateral in vivo and in vitro protective effects of the novel heat shock protein coinducer, bimoclomol: results of preclinical studies.	bimoclomol	96-106	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	66-84
11484067-1	2001	Bimoclomol, the recently developed non-toxic heat shock protein (HSP) coinducer, was shown to display multilateral protective activities against various forms of stress or injuries at the level of the cell, tissue or organism.	bimoclomol	0-10	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	45-63
11484067-1	2001	Bimoclomol, the recently developed non-toxic heat shock protein (HSP) coinducer, was shown to display multilateral protective activities against various forms of stress or injuries at the level of the cell, tissue or organism.	bimoclomol	0-10	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	65-68
11250818-6	2001	In addition, chlorophyll fluorescence (F(v)/F(m)) 1 h after the heat shocks was positively correlated with cLMW HSP expression.	Chlorophyll	13-24	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	112-115
10914665-3	2000	Conformational change of irradiated HSP was monitored by means of spectrometric measures, enzyme-linked immunosorbent assay with mouse monoclonal antibody, or human patients" sera and sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	184-206	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-39
11189451-3	2000	Adoptive transfer and immunization with selected T cell epitopes (synthetic peptides) have indicated the protection to be mediated by T cells directed to conserved hsp epitopes.	Peptides	76-84	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	164-167
10914665-3	2000	Conformational change of irradiated HSP was monitored by means of spectrometric measures, enzyme-linked immunosorbent assay with mouse monoclonal antibody, or human patients" sera and sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	polyacrylamide	207-221	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-39
10644694-8	2000	Selective removal of either the terminal mannose or the acyl residues esterifying the glycerol moiety of the ManLAM abrogates the interaction with hSP-A, further supporting the notion that the hSP-A recognition of the carbohydrate epitopes of the lipoglycans is dependent of the presence of the fatty acids.	Glycerol	86-94	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	147-150
10660532-7	2000	Chronic insulin treatment resulted in a dramatic reduction in IRS-1 and IRS-2 in the HSP, eventually (>2 h) leading to IRS protein degradation and decreased levels of tyrosyl-phosphorylated IRS proteins.	cyclo(tyrosyl-tyrosyl)	170-177	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	85-88
10644694-8	2000	Selective removal of either the terminal mannose or the acyl residues esterifying the glycerol moiety of the ManLAM abrogates the interaction with hSP-A, further supporting the notion that the hSP-A recognition of the carbohydrate epitopes of the lipoglycans is dependent of the presence of the fatty acids.	manlam	109-115	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	147-150
10644694-8	2000	Selective removal of either the terminal mannose or the acyl residues esterifying the glycerol moiety of the ManLAM abrogates the interaction with hSP-A, further supporting the notion that the hSP-A recognition of the carbohydrate epitopes of the lipoglycans is dependent of the presence of the fatty acids.	Carbohydrates	218-230	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	147-150
10644694-8	2000	Selective removal of either the terminal mannose or the acyl residues esterifying the glycerol moiety of the ManLAM abrogates the interaction with hSP-A, further supporting the notion that the hSP-A recognition of the carbohydrate epitopes of the lipoglycans is dependent of the presence of the fatty acids.	Fatty Acids	295-306	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	147-150
10826522-6	2000	TPO and HSP expression by SDS-PAGE and Western blotting.	Sodium Dodecyl Sulfate	26-29	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	8-11
10634927-1	2000	Cellular mechanisms underlying the expression of stress proteins (HSP) were studied in the human cell-line A549 submitted to a pollutant, cadmium, in the presence of several agents which modulate the glutathione level and, supposedly, the effects of this metal in the cell.	Cadmium	138-145	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	66-69
10634927-1	2000	Cellular mechanisms underlying the expression of stress proteins (HSP) were studied in the human cell-line A549 submitted to a pollutant, cadmium, in the presence of several agents which modulate the glutathione level and, supposedly, the effects of this metal in the cell.	Metals	255-260	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	66-69
10875892-7	2000	Genistein also inhibited the heat-shock-induced SAPK/JNK activation and HSP expression.	Genistein	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	72-75
10875892-9	2000	These results suggest that the heat-shock-induced actin polymerization, HSP expression, and SAPK/JNK activation may be mediated by the specific signal pathway involving GTK(s), while colchicine-induced actin polymerization and SAPK/JNK activation is regulated in a different manner.	Colchicine	183-193	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	72-75
10634927-4	2000	Treatment of cells with 20 or 40 mM N-acetyl-L-cysteine, which traps free radicals, was found to increase by 30% the glutathione level and to suppress the HSP over-expression.	Acetylcysteine	36-55	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	155-158
10634927-5	2000	From our results, it is suggested that HSP induction by cadmium in A549 cells is due, at least in part, to the oxidative stress consisting in formation of reactive oxygen species and inhibition of peroxides detoxification.	Cadmium	56-63	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	39-42
10634927-5	2000	From our results, it is suggested that HSP induction by cadmium in A549 cells is due, at least in part, to the oxidative stress consisting in formation of reactive oxygen species and inhibition of peroxides detoxification.	Reactive Oxygen Species	155-178	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	39-42
10634927-5	2000	From our results, it is suggested that HSP induction by cadmium in A549 cells is due, at least in part, to the oxidative stress consisting in formation of reactive oxygen species and inhibition of peroxides detoxification.	Peroxides	197-206	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	39-42
10620524-10	2000	It is possible that, in vivo, cell adaptation also occurs throughout chronic exposure to Cd, with a decrease of hsp induction as a consequence.	Cadmium Chloride	89-91	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	112-115
10218664-3	1999	Proteins that contain non-native modified thiols can become destablized such that they unfold into molten globule-like intermediates at or below 37 degrees C, relieving Hsf-1 negative regulation, and inducing Hsp transcription.	Sulfhydryl Compounds	42-48	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	209-212
10534609-3	1999	The analgesia of gestation or its hormonal simulation (via estrogen and progesterone administration; HSP) is substantially attenuated (>/=60%) following blockade of spinal alpha(2) (but not alpha(1)) adrenergic receptors.	Progesterone	72-84	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	101-104
10478576-1	1999	INTRODUCTION: The presence of T-cell reactivity to alphaB-crystallin in patients with multiple sclerosis (MS) has suggested that this small molecular weight heat shock protein (Hsp) may be an autoantigen in MS. MATERIAL AND METHODS: We have tested the serum of patients with clinically definite MS (n=30), other inflammatory neurological disease (n=22), non-inflammatory neurological disease (n=42) and healthy individuals (n=23) for systemic humoral responses to bovine alphaB-crystallin, to the homologous chaperone protein, alphaA-crystallin, and to another small Hsp, Hsp 27.	alphaa-crystallin	527-544	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	157-175
10478576-1	1999	INTRODUCTION: The presence of T-cell reactivity to alphaB-crystallin in patients with multiple sclerosis (MS) has suggested that this small molecular weight heat shock protein (Hsp) may be an autoantigen in MS. MATERIAL AND METHODS: We have tested the serum of patients with clinically definite MS (n=30), other inflammatory neurological disease (n=22), non-inflammatory neurological disease (n=42) and healthy individuals (n=23) for systemic humoral responses to bovine alphaB-crystallin, to the homologous chaperone protein, alphaA-crystallin, and to another small Hsp, Hsp 27.	alphaa-crystallin	527-544	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	177-180
10481271-3	1999	Densitometric analyses of 35[S]-methionine labelled protein gels indicated that levels of these hsps peaked at 3 to 4 h, following post-heat shock recovery at 37 degrees C. The presence of penicillin and streptomycin in the cell culture medium, appeared to have little effect on the kinetics of hsp synthesis.	Methionine	32-42	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	96-99
10481271-3	1999	Densitometric analyses of 35[S]-methionine labelled protein gels indicated that levels of these hsps peaked at 3 to 4 h, following post-heat shock recovery at 37 degrees C. The presence of penicillin and streptomycin in the cell culture medium, appeared to have little effect on the kinetics of hsp synthesis.	Penicillins	189-199	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	96-99
10481271-3	1999	Densitometric analyses of 35[S]-methionine labelled protein gels indicated that levels of these hsps peaked at 3 to 4 h, following post-heat shock recovery at 37 degrees C. The presence of penicillin and streptomycin in the cell culture medium, appeared to have little effect on the kinetics of hsp synthesis.	Streptomycin	204-216	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	96-99
10415040-1	1999	Previously, we reported that killing tumor cells in vivo with the HSV thymidine kinase/ganciclovir system generates potent antitumor immunity, determined in part by the mechanism by which the cells die and by the levels of inducible heat shock protein (hsp) expression induced during the process of cell death.	Ganciclovir	87-98	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	233-251
10415040-1	1999	Previously, we reported that killing tumor cells in vivo with the HSV thymidine kinase/ganciclovir system generates potent antitumor immunity, determined in part by the mechanism by which the cells die and by the levels of inducible heat shock protein (hsp) expression induced during the process of cell death.	Ganciclovir	87-98	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	253-256
10403520-2	1999	To determine the effects of intracellular GSH on expression of the heat shock genes (hsp) induced by cadmium in CDDP-resistant cancer cells, we used two human ovarian cancer cell lines: CDDP-sensitive A2780 and its CDDP-resistant derivative A2780CP.	Glutathione	42-45	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	85-88
10403520-2	1999	To determine the effects of intracellular GSH on expression of the heat shock genes (hsp) induced by cadmium in CDDP-resistant cancer cells, we used two human ovarian cancer cell lines: CDDP-sensitive A2780 and its CDDP-resistant derivative A2780CP.	Cadmium	101-108	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	85-88
10403520-2	1999	To determine the effects of intracellular GSH on expression of the heat shock genes (hsp) induced by cadmium in CDDP-resistant cancer cells, we used two human ovarian cancer cell lines: CDDP-sensitive A2780 and its CDDP-resistant derivative A2780CP.	Cisplatin	112-116	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	85-88
10366587-5	1999	Upon exposure of cells to heat shock, the heavy metal cadmium, or the amino acid analogue azetidine, transcription at the hsp90alpha and hsp70 gene loci is strongly induced, and both hsp transcription sites become associated with speckles in >90% of the cells.	Metals	48-53	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	122-125
10366587-5	1999	Upon exposure of cells to heat shock, the heavy metal cadmium, or the amino acid analogue azetidine, transcription at the hsp90alpha and hsp70 gene loci is strongly induced, and both hsp transcription sites become associated with speckles in >90% of the cells.	Cadmium	54-61	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	122-125
10366587-5	1999	Upon exposure of cells to heat shock, the heavy metal cadmium, or the amino acid analogue azetidine, transcription at the hsp90alpha and hsp70 gene loci is strongly induced, and both hsp transcription sites become associated with speckles in >90% of the cells.	azetidine	90-99	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	122-125
10331966-1	1999	Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis of cancer cells.	Quercetin	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	58-76
10331966-1	1999	Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis of cancer cells.	Quercetin	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	78-81
10331966-1	1999	Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis of cancer cells.	Flavonoids	15-24	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	58-76
10331966-1	1999	Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis of cancer cells.	Flavonoids	15-24	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	78-81
10525270-2	1999	Iodoacetamide (IDAM), a prototypical alkyating agent, induces both Grp and Hsp synthesis in renal epithelial cells and causes necrosis which is prevented by prior activation of the ER stress response (pre-ER stress) [Liu, H., et al.	Iodoacetamide	0-13	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-78
10525270-2	1999	Iodoacetamide (IDAM), a prototypical alkyating agent, induces both Grp and Hsp synthesis in renal epithelial cells and causes necrosis which is prevented by prior activation of the ER stress response (pre-ER stress) [Liu, H., et al.	Iodoacetamide	15-19	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-78
10103186-7	1999	The possibility that hsp70 could play a role in the control of rhinovirus replication is suggested by the fact that a different class of HSP inducers, the cyclopentenone prostaglandins PGA1 and delta 12-PGJ2, were also effective in inhibiting HRV replication in HeLa cells.	cyclopentenone	155-169	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	137-140
10103186-7	1999	The possibility that hsp70 could play a role in the control of rhinovirus replication is suggested by the fact that a different class of HSP inducers, the cyclopentenone prostaglandins PGA1 and delta 12-PGJ2, were also effective in inhibiting HRV replication in HeLa cells.	delta 12-pgj2	194-207	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	137-140
9880517-3	1999	Following the withdrawal of treatment with cortisol or the hormone antagonist RU486, GRs recycled rapidly into hsp-associated, hormone-responsive complexes.	Hydrocortisone	43-51	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	111-114
10069381-5	1999	These data suggest that ROS contribute to the induction of hsps and furthermore, that hsp induction and apoptosis are mutually exclusive events within the same cell.	Reactive Oxygen Species	24-27	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	59-62
9880517-3	1999	Following the withdrawal of treatment with cortisol or the hormone antagonist RU486, GRs recycled rapidly into hsp-associated, hormone-responsive complexes.	Mifepristone	78-83	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	111-114
9886484-7	1999	Differential effects of the transcriptional inhibitor actinomycin D on the various stress proteins revealed transcriptional regulation of HSP and HO during EP, whereas the induction of ferritin was posttranscriptionally regulated.	Dactinomycin	54-67	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	138-141
9632711-8	1998	HSP induction by 3,4-dichloroisocoumarin is associated with antiviral activity during rhabdovirus infection.	3,4-dichloroisocoumarin	17-40	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
9892498-0	1998	Metal chelator NNNNN-tetrakis-(2-pyridymethyl)ethylene diamine inhibits the induction of heat shock protein 70 synthesis by heat in cultured keratinocytes.	Metals	0-5	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	89-107
9892498-0	1998	Metal chelator NNNNN-tetrakis-(2-pyridymethyl)ethylene diamine inhibits the induction of heat shock protein 70 synthesis by heat in cultured keratinocytes.	nnnnn-tetrakis-(2-pyridymethyl)ethylene diamine	15-62	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	89-107
9744814-5	1998	Similarly, the Hsp27 dephosphorylation/insolubilization/granulation and the cytoskeletal and morphological disturbances resulting from lack of ATP were suppressed in heat-preconditioned (thermotolerant) cultures, this effect being sensitive to quercetin, a blocker of Hsp induction.	Quercetin	244-253	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	15-18
9744814-7	1998	These data suggest that PP inhibitors as well as heat-inducible Hsp(s) can protect ischemia-stressed cells by preventing the ATP loss-provoked protein dephosphorylation and breakdown of the actin cytoskeleton.	Adenosine Triphosphate	125-128	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	64-67
9535852-3	1998	LexA-HSF1 chimeras were previously shown to be regulated identically to HSF1, except that they transactivate promoters with LexA-binding sites instead of hsp promoters.	lexa	0-4	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	154-157
9630517-1	1998	Pain thresholds are elevated during gestation and following the simulation of pregnancy blood levels of estrogen and progesterone (hormone simulated pregnancy; HSP).	Progesterone	117-129	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	160-163
9672248-0	1998	Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in stress induction of the Hsp response.	Glutathione	20-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	125-128
9672248-4	1998	Based on the chemical nature of inducers and on results reported from several studies, we hypothesized that inducers of the Hsp response may be generally capable of triggering oxidation of non-protein thiols, particularly glutathione.	Sulfhydryl Compounds	201-207	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	124-127
9672248-4	1998	Based on the chemical nature of inducers and on results reported from several studies, we hypothesized that inducers of the Hsp response may be generally capable of triggering oxidation of non-protein thiols, particularly glutathione.	Glutathione	222-233	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	124-127
9585183-5	1998	The experiments performed to investigate the influence of Hsp/Hsc70 on the reaction of U-937 cells to differentiation stimuli demonstrated that the addition of the protein prior to PMA was able to inhibit binding of proper transcription factors to double-symmetry and cAMP-response elements of the c-fos early response gene promoter.	Cyclic AMP	268-272	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	58-61
9641298-6	1998	The area of macroscopic damage was significantly reduced only in rats where hSP (200 micromol/L) was given in conjunction with ASA (P < 0.05).	Aspirin	127-130	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	76-79
9453549-4	1998	Analysis of cellular energy nucleotides showed an increase of the ADP/ATP ratio after reoxygenation, which synchronized with activation of the HSP promoter.	Adenosine Diphosphate	66-69	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	143-146
9538196-2	1998	The CHX-induced suppression of hsp gene expression induced no development of thermotolerance.	Cycloheximide	4-7	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
9538196-5	1998	Moreover, prior feeding of the proline analog L-azetidine 2-carboxylic acid abrogated the CHX-induced suppression of hsp gene expression.	Proline	31-38	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	117-120
9538196-5	1998	Moreover, prior feeding of the proline analog L-azetidine 2-carboxylic acid abrogated the CHX-induced suppression of hsp gene expression.	L-Azetidine-2-carboxylic acid	46-75	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	117-120
9453549-4	1998	Analysis of cellular energy nucleotides showed an increase of the ADP/ATP ratio after reoxygenation, which synchronized with activation of the HSP promoter.	Adenosine Triphosphate	70-73	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	143-146
9453549-5	1998	Activation of the HSP promoter was also observed after an addition of iodoacetic acid to hypoxic astrocytes, which reached the maximum when the ADP/ATP ratio reached 50%, but further decline in the energy profile caused inactivation of this promoter.	Iodoacetic Acid	70-85	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-21
9453549-5	1998	Activation of the HSP promoter was also observed after an addition of iodoacetic acid to hypoxic astrocytes, which reached the maximum when the ADP/ATP ratio reached 50%, but further decline in the energy profile caused inactivation of this promoter.	Adenosine Diphosphate	144-147	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-21
9453549-5	1998	Activation of the HSP promoter was also observed after an addition of iodoacetic acid to hypoxic astrocytes, which reached the maximum when the ADP/ATP ratio reached 50%, but further decline in the energy profile caused inactivation of this promoter.	Adenosine Triphosphate	148-151	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-21
9367858-2	1997	To determine whether quercetin could inhibit hsp expression in breast cancer cells, we used the human breast cancer cell line, MDA-MB-231.	Quercetin	21-30	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	45-48
9449851-0	1998	The small, methionine-rich chloroplast heat-shock protein protects photosystem II electron transport during heat stress.	Methionine	11-21	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	39-57
9283030-1	1997	The hot acid extract of pea hull, HSP, was rich in galacturonic acid, arabinose and xylose.	hot acid	4-12	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	34-37
9296382-4	1997	The present study was designed to determine how the new hsp 90-binding agent geldanamycin, which was previously shown to disrupt the formation of steroid receptor/hsp complexes, interferes with MR- and GR-mediated transactivation in intact cells.	geldanamycin	77-89	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	56-59
9296382-20	1997	showed that the hspE90-binding agent geldanamycin can specifically disrupt GR/hsp association, thus inhibiting glucocorticoid-mediated transcriptional activation (22).	geldanamycin	37-49	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	16-19
9283030-1	1997	The hot acid extract of pea hull, HSP, was rich in galacturonic acid, arabinose and xylose.	galacturonic acid	51-68	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	34-37
9283030-1	1997	The hot acid extract of pea hull, HSP, was rich in galacturonic acid, arabinose and xylose.	Arabinose	70-79	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	34-37
9283030-1	1997	The hot acid extract of pea hull, HSP, was rich in galacturonic acid, arabinose and xylose.	Xylose	84-90	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	34-37
9283030-3	1997	The copper-soluble fraction represented 26% of HSP and was mostly composed of an arabinan with a low degree of branching, some heteroxylans and a glucan, probably starch.	Copper	4-10	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	47-50
9283030-4	1997	The copper-precipitate (74% of HSP) contained pectins and some residual arabinan, xylan, glucan and mannan.	Copper	4-10	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
9118008-10	1997	HSP function was observed by using anti-sense strategy, short "5 anti-sense cDNA" hsp oligonucleotides inhibited hsp expression during gastrulation in the whole embryo cultures.	Oligonucleotides	86-102	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
9252516-2	1997	PSP and recombinant hSP reduced gastric mucosal damage caused by a combination of subcutaneous indomethacin and restraint stress in the conscious rat.	Indomethacin	95-107	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	20-23
9118008-10	1997	HSP function was observed by using anti-sense strategy, short "5 anti-sense cDNA" hsp oligonucleotides inhibited hsp expression during gastrulation in the whole embryo cultures.	Oligonucleotides	86-102	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	82-85
9118008-10	1997	HSP function was observed by using anti-sense strategy, short "5 anti-sense cDNA" hsp oligonucleotides inhibited hsp expression during gastrulation in the whole embryo cultures.	Oligonucleotides	86-102	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	113-116
8988805-7	1996	The carbon monoxide-exposed group showed the highest incidence of anti-Hsp antibodies.	Carbon Monoxide	4-19	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	71-74
8783328-16	1996	sufentanil was observed on day 19 of HSP over all doses tested (0.1-1 nmol).	Sufentanil	0-10	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	37-40
8908204-6	1996	A pretreatment with cadmium, which hardly induces synthesis of this hsp, does induce a tolerance to (re)-induction by heat shock, which normally induces hsp60.	Cadmium	20-27	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	68-71
8923463-3	1996	Incubation of nuclear extracts from MCF-7 cells with an Hsp 27-[32P]Sp1/ERE oligonucleotide results in formation of an Sp1/ER complex.	Phosphorus-32	64-67	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	56-59
8923463-3	1996	Incubation of nuclear extracts from MCF-7 cells with an Hsp 27-[32P]Sp1/ERE oligonucleotide results in formation of an Sp1/ER complex.	Oligonucleotides	76-91	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	56-59
8798781-7	1996	We now report that sodium arsenite, a prototype for stressors fostering cytoplasmic protein misfolding, also inhibits translational initiation through activation of PKR while subsequently inducing the heat shock protein (HSP) chaperones.	sodium arsenite	19-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	201-219
8798781-7	1996	We now report that sodium arsenite, a prototype for stressors fostering cytoplasmic protein misfolding, also inhibits translational initiation through activation of PKR while subsequently inducing the heat shock protein (HSP) chaperones.	sodium arsenite	19-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	221-224
8798781-12	1996	Induction of either the HSP or GRP chaperones was accompanied by development of translational tolerance to either Ca2+-mobilizing agents or arsenite.	arsenite	140-148	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	24-27
8891903-7	1996	By contrast, only the hsp 72 was expressed using Poly(A)+ RNA extracted from cells heated at 42 degrees C for 1 h. Affinity chromatography experiments on ATP-agarose showed that hsp 66 did not bind ATP in vitro.	Poly A	49-56	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	22-25
8891903-7	1996	By contrast, only the hsp 72 was expressed using Poly(A)+ RNA extracted from cells heated at 42 degrees C for 1 h. Affinity chromatography experiments on ATP-agarose showed that hsp 66 did not bind ATP in vitro.	ATP-sepharose	154-165	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	22-25
8891903-9	1996	The nuclear-associated hsp 66 was found to be tightly bound to nuclear structures and could not be extracted by incubation in ATP-containing buffer.	Adenosine Triphosphate	126-129	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	23-26
8668927-2	1996	A series of 47 overlapping synthetic peptides (15ers) derived from the sequence of the Mycobacterium tuberculosis 65 kDa HSP was used in ELISA.	Peptides	37-45	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	121-124
9139449-4	1996	The latter are translocated into cell nucleus activate the function of genetic apparatus, change biosynthesis of specific enzymes realizing intracellular glucocorticoid effect Receptor mechanism of antiglucocorticoid effect is realized via competition of steroid and non-steroid drugs with glucocorticoids for binding sites on GR or pharmacological stabilization of GR-HSP complex, decreasing 4SGR release, 4S GR-G forming, and 4SGR-G translocation into cell nucleus.	Steroids	255-262	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	369-372
9139449-4	1996	The latter are translocated into cell nucleus activate the function of genetic apparatus, change biosynthesis of specific enzymes realizing intracellular glucocorticoid effect Receptor mechanism of antiglucocorticoid effect is realized via competition of steroid and non-steroid drugs with glucocorticoids for binding sites on GR or pharmacological stabilization of GR-HSP complex, decreasing 4SGR release, 4S GR-G forming, and 4SGR-G translocation into cell nucleus.	Steroids	271-278	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	369-372
9052936-3	1996	Synthesis of 70 kDa hsp (hsp70) and 90 kDa hsp (hsp90) was determined by SDS-PAGE and Western blot analysis in porcine day 6 embryos subjected to heat stresses.	Sodium Dodecyl Sulfate	73-76	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	20-23
9052936-3	1996	Synthesis of 70 kDa hsp (hsp70) and 90 kDa hsp (hsp90) was determined by SDS-PAGE and Western blot analysis in porcine day 6 embryos subjected to heat stresses.	Sodium Dodecyl Sulfate	73-76	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	25-28
8732304-11	1996	In vivo, rITF and hSP are able to prevent much of the gastric damage effect by a single dose of indomethacin, when given systemically.	Indomethacin	96-108	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-21
8856978-5	1996	While the protective antioxidant responses induced by ROS in prokaryotes and eukaryotes are rather conserved (for example, SOD, HSP...), the regulators for these genes do not appear to be conserved.	ros	54-57	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	128-131
11885252-1	1996	In order to establish whether tissues damaged by Chronic Periapical Pathology (CPP) of endodontic origin produced heat shock protein (HSP) capable of attracting reactive lymphocytes, paraffin sections of samples from the oral cavity of 10 patients with CPP were incubated with commercially available anti-HSP monoclonal antibodies.	Paraffin	183-191	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	114-132
11885252-1	1996	In order to establish whether tissues damaged by Chronic Periapical Pathology (CPP) of endodontic origin produced heat shock protein (HSP) capable of attracting reactive lymphocytes, paraffin sections of samples from the oral cavity of 10 patients with CPP were incubated with commercially available anti-HSP monoclonal antibodies.	Paraffin	183-191	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	134-137
8548766-1	1996	Prostaglandins of the A type (PGAs) function as signals for heat shock protein (hsp) synthesis in mammalian cells.	Prostaglandins	0-14	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	60-78
8548766-1	1996	Prostaglandins of the A type (PGAs) function as signals for heat shock protein (hsp) synthesis in mammalian cells.	Prostaglandins	0-14	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
8548766-1	1996	Prostaglandins of the A type (PGAs) function as signals for heat shock protein (hsp) synthesis in mammalian cells.	Prostaglandins A	30-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	60-78
8548766-1	1996	Prostaglandins of the A type (PGAs) function as signals for heat shock protein (hsp) synthesis in mammalian cells.	Prostaglandins A	30-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
8548766-2	1996	In human K562 erythroleukemic cells, PGA1 induces the synthesis of a M(r) 70,000 hsp (hsp70) by cycloheximide-sensitive activation of heat shock transcription factor (HSF).	prostaglandin A1	37-41	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
8548766-2	1996	In human K562 erythroleukemic cells, PGA1 induces the synthesis of a M(r) 70,000 hsp (hsp70) by cycloheximide-sensitive activation of heat shock transcription factor (HSF).	Cycloheximide	96-109	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
8856986-3	1996	We propose that mitochondria are a key organelle in determining the outcome of inflammation, because they are both the cellular "switchboard" for apoptosis and a selective target for the protective effects of HSP against the cytotoxic effects of TNF alpha and ROS.	ros	260-263	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	209-212
7628864-2	1995	Here we compared the stress response in monocytes and polymorphonuclear neutrophils during exposure to the classical inducers of HSP, i.e., HS and cadmium.	Cadmium	147-154	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	129-132
7581991-7	1995	HSP 70a and HSP 90 alpha expression were stimulated by oestradiol.	Estradiol	55-65	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
8645616-3	1996	In fact, heat shock protein association (hsp) is required for high affinity ligand-binding of the MR. After incubation of purified MBP- or GST-HBD with rabbit reticulocyte lysate, known to be rich in heat shock proteins, we obtained saturable binding of [3H]aldosterone.	3h]aldosterone	255-269	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	41-44
7775471-4	1995	The present study was undertaken to establish whether this increase in HSP expression was related to O2-.	Superoxides	101-103	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	71-74
7775471-6	1995	Thus, the effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) were compared with those of heat shock on the expression, in PBM, of the major HSP, hsp70 and hsp90, using biometabolic labeling, Western and Northern blotting, and gel mobility shift assays.	Tetradecanoylphorbol Acetate	72-75	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	156-159
7761999-2	1995	This study has focussed on the pattern of HSP synthesis in relation to cytotoxicity and their dependence on doses of cadmium chloride.	Cadmium Chloride	117-133	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	42-45
7529764-6	1995	The K8/18-hsp/c70 complex can be dissociated in a Mg-ATP-dependent manner that requires ATP hydrolysis.	Magnesium	50-52	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	10-13
7788560-4	1995	Exposure to 8% ethanol for 15 min resulted in both growth inhibition and HSP overexpression.	Ethanol	15-22	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	73-76
7529764-6	1995	The K8/18-hsp/c70 complex can be dissociated in a Mg-ATP-dependent manner that requires ATP hydrolysis.	Adenosine Triphosphate	53-56	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	10-13
7529764-6	1995	The K8/18-hsp/c70 complex can be dissociated in a Mg-ATP-dependent manner that requires ATP hydrolysis.	Adenosine Triphosphate	88-91	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	10-13
7529764-7	1995	Binding of hsp to K8/18 can be reconstituted using purified bovine hsp70 and human K8/18 immunoprecipitates that have been depleted of bound hsp/c70 and increases slightly in the presence of ATP.	Adenosine Triphosphate	191-194	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	11-14
7988664-4	1994	Other studies suggest that various anti-inflammatory drugs, including acetylsalicyclic acid, auranofin and dexamethasone, can also facilitate HSP expression in macrophages.	Aspirin	70-91	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	142-145
7565172-1	1995	The production of HSP by periodontopathic Gram-negative bacteria was examined by SDS-PAGE, two dimensional gel electrophoresis, and Western blotting using monoclonal antibodies against HSPs.	Sodium Dodecyl Sulfate	81-84	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	18-21
7988662-3	1994	Whereas both ROS and cytokines have the potential to regulate the expression of heat shock (HS)/stress proteins (HSP), it appears that these proteins in turn have the ability to protect cells and tissues from the deleterious effects of inflammation.	Reactive Oxygen Species	13-16	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	113-116
7479312-5	1995	Unlabeled hSP partially inhibited [125I]rITF binding at a concentration of 1 microM when compared with the same concentration of unlabeled rITF.	TFF3 protein, rat	40-44	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	10-13
7479312-6	1995	These studies support earlier observations for the existence of trefoil binding sites in the gastrointestinal tract and further suggest that hSP has affinity for the mucosal rITF binding site.	TFF3 protein, rat	174-178	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	141-144
7988664-4	1994	Other studies suggest that various anti-inflammatory drugs, including acetylsalicyclic acid, auranofin and dexamethasone, can also facilitate HSP expression in macrophages.	Auranofin	93-102	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	142-145
7988664-4	1994	Other studies suggest that various anti-inflammatory drugs, including acetylsalicyclic acid, auranofin and dexamethasone, can also facilitate HSP expression in macrophages.	Dexamethasone	107-120	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	142-145
7520998-7	1994	In contrast, exposure to hydrogen peroxide or bleomycin induced DNA damage, but no HSP synthesis, suggesting that oxidation-induced DNA damage and HSP synthesis proceed independently in U937 cells.	Hydrogen Peroxide	25-42	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	147-150
7820687-4	1994	Intranigral injection of AP-7 increased the duration of electrographic seizure discharges and the number of HSP-positive and acid fuchsin stained cells in all hippocampal sectors, suggesting that blockade of the NMDA receptors in SNpr enhanced neural injury.	2-amino-7-phosphonoheptanoic acid	25-29	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	108-111
7520998-7	1994	In contrast, exposure to hydrogen peroxide or bleomycin induced DNA damage, but no HSP synthesis, suggesting that oxidation-induced DNA damage and HSP synthesis proceed independently in U937 cells.	Bleomycin	46-55	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	147-150
8037840-13	1994	The stimulatory effect of iodide on hsp induction may also provide an explanation for the frequent occurrence of thyroid autoimmune diseases after iodine exposure.	Iodides	26-32	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-39
8037840-13	1994	The stimulatory effect of iodide on hsp induction may also provide an explanation for the frequent occurrence of thyroid autoimmune diseases after iodine exposure.	Iodine	147-153	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-39
1636745-8	1992	3) HSP from either ADH withdrawal or unstimulated bladders exhibited low Pf and acidified after addition of extravesicular ATP; moreover, protein compositions of purified HSP were distinct from those of purified IP.	Adenosine Triphosphate	123-126	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	3-6
8328983-1	1993	We recently showed that delta 12-prostaglandin (PG) J2 bound to the thiol groups of nuclear proteins and stimulated the synthesis of a 67-kDa heat shock protein (HSP) in porcine aortic endothelial cells, and that intracellular glutathione (GSH) blocked this binding and HSP induction (Koizumi et al., Biochem Pharmacol 44: 1597-1602, 1992).	delta 12-prostaglandin	24-46	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	142-160
8328983-1	1993	We recently showed that delta 12-prostaglandin (PG) J2 bound to the thiol groups of nuclear proteins and stimulated the synthesis of a 67-kDa heat shock protein (HSP) in porcine aortic endothelial cells, and that intracellular glutathione (GSH) blocked this binding and HSP induction (Koizumi et al., Biochem Pharmacol 44: 1597-1602, 1992).	delta 12-prostaglandin	24-46	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	162-165
8328983-1	1993	We recently showed that delta 12-prostaglandin (PG) J2 bound to the thiol groups of nuclear proteins and stimulated the synthesis of a 67-kDa heat shock protein (HSP) in porcine aortic endothelial cells, and that intracellular glutathione (GSH) blocked this binding and HSP induction (Koizumi et al., Biochem Pharmacol 44: 1597-1602, 1992).	delta 12-prostaglandin	24-46	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	270-273
8328983-1	1993	We recently showed that delta 12-prostaglandin (PG) J2 bound to the thiol groups of nuclear proteins and stimulated the synthesis of a 67-kDa heat shock protein (HSP) in porcine aortic endothelial cells, and that intracellular glutathione (GSH) blocked this binding and HSP induction (Koizumi et al., Biochem Pharmacol 44: 1597-1602, 1992).	Glutathione	227-238	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	142-160
8328983-1	1993	We recently showed that delta 12-prostaglandin (PG) J2 bound to the thiol groups of nuclear proteins and stimulated the synthesis of a 67-kDa heat shock protein (HSP) in porcine aortic endothelial cells, and that intracellular glutathione (GSH) blocked this binding and HSP induction (Koizumi et al., Biochem Pharmacol 44: 1597-1602, 1992).	Glutathione	227-238	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	162-165
8328983-1	1993	We recently showed that delta 12-prostaglandin (PG) J2 bound to the thiol groups of nuclear proteins and stimulated the synthesis of a 67-kDa heat shock protein (HSP) in porcine aortic endothelial cells, and that intracellular glutathione (GSH) blocked this binding and HSP induction (Koizumi et al., Biochem Pharmacol 44: 1597-1602, 1992).	Glutathione	240-243	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	142-160
8328983-1	1993	We recently showed that delta 12-prostaglandin (PG) J2 bound to the thiol groups of nuclear proteins and stimulated the synthesis of a 67-kDa heat shock protein (HSP) in porcine aortic endothelial cells, and that intracellular glutathione (GSH) blocked this binding and HSP induction (Koizumi et al., Biochem Pharmacol 44: 1597-1602, 1992).	Glutathione	240-243	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	162-165
8328983-2	1993	In the present study, we examined the molecular mechanism underlying the induction of HSP by delta 12-PGJ2.	delta(12)-prostaglandin J(2)	93-106	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	86-89
8328983-7	1993	These results taken together suggest that delta 12-PGJ2 binds to the thiol groups of nuclear proteins and activates HSF, leading to the synthesis of the 67-kDa HSP.	delta(12)-prostaglandin J(2)	42-55	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	160-163
8328983-7	1993	These results taken together suggest that delta 12-PGJ2 binds to the thiol groups of nuclear proteins and activates HSF, leading to the synthesis of the 67-kDa HSP.	Sulfhydryl Compounds	69-74	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	160-163
8499494-0	1993	Oxygen free radicals as inducers of heat shock protein synthesis in cultured human neuroblastoma cells: relevance to neurodegenerative disease.	oxygen free radicals	0-20	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-54
8499494-1	1993	We studied heat shock protein (HSP) synthesis by cultured human neuroblastoma cells in response to either hyperthermia or high levels of superoxide anion (oxygen free radical).	Superoxides	137-153	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	11-29
8499494-1	1993	We studied heat shock protein (HSP) synthesis by cultured human neuroblastoma cells in response to either hyperthermia or high levels of superoxide anion (oxygen free radical).	Superoxides	137-153	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
8499494-1	1993	We studied heat shock protein (HSP) synthesis by cultured human neuroblastoma cells in response to either hyperthermia or high levels of superoxide anion (oxygen free radical).	oxygen free radical	155-174	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	11-29
8499494-1	1993	We studied heat shock protein (HSP) synthesis by cultured human neuroblastoma cells in response to either hyperthermia or high levels of superoxide anion (oxygen free radical).	oxygen free radical	155-174	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
8499494-3	1993	Exposure to superoxide anion in the presence of the free radical scavenging enzymes, superoxide dismutase and catalase improved cell survival and prevented HSP induction.	Superoxides	12-28	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	156-159
8499494-4	1993	These findings suggest a common mechanism by which various forms of injury, such as hyperthermia, cause HSP induction, that is, via oxidative stress or increased production of oxygen free radicals.	oxygen free radicals	176-196	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	104-107
7550607-5	1994	We also confirm that the trefoil peptides pS2 and hSP, which play a major role in the repair process, are spatially segregated within the UACL with a zone of overlap in the duct.	uacl	138-142	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	50-53
8440393-8	1993	The structure of the r-hSP and the glycosylated r-hSP was determined by amino acid analysis and carbohydrate composition analysis as well as by peptide mapping, amino acid sequencing and mass spectrometric analysis.	Carbohydrates	96-108	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	50-53
8283019-2	1993	In the UACL, human spasmolytic polypeptide (hSP) mRNA and peptide are present in the acinar and proximal duct cells, whereas pS2 mRNA and peptide are found in the distal duct cells and in the surface cells.	uacl	7-11	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	44-47
1389096-6	1992	In isolated beta cells cultured at high glucose concentration a doubling in the content of 65-kDa HSP mRNA was seen compared with islets cultured at low glucose concentration (p < 0.05).	Glucose	40-47	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	98-101
1389096-6	1992	In isolated beta cells cultured at high glucose concentration a doubling in the content of 65-kDa HSP mRNA was seen compared with islets cultured at low glucose concentration (p < 0.05).	Glucose	153-160	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	98-101
1389096-9	1992	The expression of 65-kDa HSP mRNA was increased in RINm5F cells following heat shock, while no induction was seen after stimulation with glucose, TPA or IBMX.	Tetradecanoylphorbol Acetate	146-149	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	25-28
1375619-0	1992	Induction of 72-kD heat shock protein and cytoskeleton damage by cytotoxic prostaglandin delta 12-PGJ2 in transformed human epidermal cells in culture.	prostaglandin delta 12-pgj2	75-102	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	19-37
1617638-10	1992	We also found that the level of doxorubicin protection conferred by the overexpression of hsp was lower than that obtained in cells expressing a multidrug resistance phenotype (MDA-A1R cells).	Doxorubicin	32-43	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	90-93
1375619-2	1992	To clarify the mechanism of PG cytotoxicity in human epidermal cells, we examined the effects of delta 12-PGJ2 on the induction of a heat shock protein (HSP), and on the organization of cytoskeletons in the HSC-I-transformed human epidermal cell line.	delta 12-pgj2	97-110	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	133-151
1375619-2	1992	To clarify the mechanism of PG cytotoxicity in human epidermal cells, we examined the effects of delta 12-PGJ2 on the induction of a heat shock protein (HSP), and on the organization of cytoskeletons in the HSC-I-transformed human epidermal cell line.	delta 12-pgj2	97-110	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	153-156
1375619-3	1992	Immunoblot analysis using a monoclonal antibody specific for the 72-kD heat shock protein (HSP72) revealed that a 12-h incubation with 5 micrograms/ml of delta 12-PGJ2 induced HSP72 formation in HSC-I cells.	delta 12	154-162	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	71-89
1375619-3	1992	Immunoblot analysis using a monoclonal antibody specific for the 72-kD heat shock protein (HSP72) revealed that a 12-h incubation with 5 micrograms/ml of delta 12-PGJ2 induced HSP72 formation in HSC-I cells.	9-deoxy-delta-9-prostaglandin D2	163-167	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	71-89
1740380-5	1992	HSP 72 reactivity was determined using sodium dodecyl sulfate polyacrylamide-gel electrophoresis of cellular extracts, followed by immunoblotting with a mouse monoclonal anti-HSP 72 antibody and quantitative scanning densitometry.	Sodium Dodecyl Sulfate	39-61	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
1740380-5	1992	HSP 72 reactivity was determined using sodium dodecyl sulfate polyacrylamide-gel electrophoresis of cellular extracts, followed by immunoblotting with a mouse monoclonal anti-HSP 72 antibody and quantitative scanning densitometry.	polyacrylamide	62-76	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
1370842-3	1992	Inhibition of overall protein and heat shock protein (HSP) synthesis (greater than 95%) by cycloheximide (25 micrograms/ml) during tolerance development nearly completely abolished thermotolerance induced by arsenite, while significant levels of heat-induced thermotolerance were still apparent.	Cycloheximide	91-104	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	54-57
1958851-0	1991	1-Hexylcarbamoyl-5-fluorouracil alters the expression of heat shock protein in HeLa cells.	carmofur	0-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	57-75
1370842-3	1992	Inhibition of overall protein and heat shock protein (HSP) synthesis (greater than 95%) by cycloheximide (25 micrograms/ml) during tolerance development nearly completely abolished thermotolerance induced by arsenite, while significant levels of heat-induced thermotolerance were still apparent.	arsenite	208-216	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	54-57
1922692-5	1991	Whereas, levels of HSP mRNA dropped at small doses of methamphetamine and increased dramatically at large doses.	Methamphetamine	54-69	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	19-22
1651981-0	1991	Suppression of virus replication by prostaglandin A is associated with heat shock protein synthesis.	Prostaglandins A	36-51	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	71-89
1899362-3	1991	The response to a purified mycobacterial 65-kDa heat shock protein (hsp), which migrated in fraction 2, was highly correlated (r = 0.89, P less than 0.001) with the response to the crude AP-MT.	ap-mt	187-192	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	48-66
1899362-3	1991	The response to a purified mycobacterial 65-kDa heat shock protein (hsp), which migrated in fraction 2, was highly correlated (r = 0.89, P less than 0.001) with the response to the crude AP-MT.	ap-mt	187-192	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	68-71
1958851-1	1991	We determined the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a masked compound of 5-fluorouracil, on the expression of heat shock protein (HSP) in heat-treated HeLa cells.	carmofur	28-59	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	126-144
1958851-1	1991	We determined the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a masked compound of 5-fluorouracil, on the expression of heat shock protein (HSP) in heat-treated HeLa cells.	carmofur	28-59	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	146-149
1958851-1	1991	We determined the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a masked compound of 5-fluorouracil, on the expression of heat shock protein (HSP) in heat-treated HeLa cells.	carmofur	61-65	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	126-144
1958851-1	1991	We determined the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a masked compound of 5-fluorouracil, on the expression of heat shock protein (HSP) in heat-treated HeLa cells.	carmofur	61-65	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	146-149
1958851-1	1991	We determined the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a masked compound of 5-fluorouracil, on the expression of heat shock protein (HSP) in heat-treated HeLa cells.	Fluorouracil	45-59	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	126-144
1958851-1	1991	We determined the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a masked compound of 5-fluorouracil, on the expression of heat shock protein (HSP) in heat-treated HeLa cells.	Fluorouracil	45-59	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	146-149
1677814-4	1991	In cells pulse-labeled with [35S]-methionine, a significant number of newly synthesized mitochondrial proteins co-precipitated with either hsp 58 or grp 75.	Sulfur-35	29-32	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	139-142
1677814-4	1991	In cells pulse-labeled with [35S]-methionine, a significant number of newly synthesized mitochondrial proteins co-precipitated with either hsp 58 or grp 75.	Methionine	34-44	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	139-142
2290113-3	1990	While the function of pS2 is unknown, pS2 protein has been shown to be homologous with the gastrointestinal peptide hormone pancreatic spasmolytic polypeptide (PSP) and its human counterpart hSP, in which a 5-cysteine domain is tandemly repeated.	5-cysteine	207-217	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	191-194
2290113-7	1990	We further show that the co-expression of pS2 and hSP in gastric surface epithelial cells is also associated with the secretion of EGF/URO in the subjacent mucous neck cells.	3-(1H-imidazol-4-yl)propanoic acid	135-138	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	50-53
1691787-2	1990	The deglycosylation of HSP-gP was performed chemically with TFMS hydrolysis and enzymatically in the presence of detergent and further treated with periodic acid after fixing deglycosylated HSP on plastic wells.	Periodic Acid	148-161	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	23-26
2374009-3	1990	Specifically, 72K hsp is associated with L-NC, and 72K and 73K hsp are associated with Df-NC.	df-nc	87-92	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	63-66
2118477-8	1990	PMN and LMB labelled with 35S-methionine led to heat-shock protein (HSP; 65,000, 83,000 MW) expression after heat-shock treatment at 42 degrees or in the presence of NDGA (1 x 10(-5) M) at 37 degrees.	leptomycin B	8-11	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	48-66
2118477-8	1990	PMN and LMB labelled with 35S-methionine led to heat-shock protein (HSP; 65,000, 83,000 MW) expression after heat-shock treatment at 42 degrees or in the presence of NDGA (1 x 10(-5) M) at 37 degrees.	35s-methionine	26-40	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	48-66
1691787-2	1990	The deglycosylation of HSP-gP was performed chemically with TFMS hydrolysis and enzymatically in the presence of detergent and further treated with periodic acid after fixing deglycosylated HSP on plastic wells.	Periodic Acid	148-161	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	190-193
34599990-8	2021	Furthermore, CAP-treated SP-PEI-PPy NP-MC polymeric complexes possessed augmented mechanical properties, biocompatibility, sustainable drug release, drug-retention effects, and near-infrared (NIR)-induced hyperthermia effects that drove heat-shock protein (HSP) expression with drug permeation to deep lesions.	sp-pei	25-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	237-255
2337963-1	1990	Human splenin (hSP) was synthesized by assembling eight peptide fragments followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole (molar ratios, 1:1) in trifluoroacetic acid in the presence of m-cresol and dimethylselenium.	Trifluoroacetic Acid	172-192	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	15-18
25771395-7	2015	Inhibition of Hsp70/Hsc70 activity synergistically exacerbated MG132 toxicity in allocortical neurons more than neocortical neurons, suggesting that the allocortex is more reliant on these Hsp defenses.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	63-68	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	14-17
34890970-5	2022	A highly-efficient diradical-featured croconium-based photothermal agent and a natural cytotoxic heat shock protein (HSP) inhibitor were co-loaded in redox-sensitive chitosan matrices to realize the synergistic photothermal-chemo therapy.	croconium	38-47	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	117-120
2303034-6	1990	Computer analysis revealed that the pattern of conserved cysteine residues in hSP and pS2, the P domain, is present at the N termini of two other mammalian proteins, intestinal sucrase-isomaltase and lysosomal alpha-glucosidase.	Cysteine	57-65	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	78-81
34727817-8	2022	The rate of DPPB after CSP was 0%, however, DPPB after conversion to HSP occurred in 1 case (33.3% (1/3)).	2,3- O-isopropylidene-2,3-dihydroxyl-1,4-bis(diphenylphosphino)butane	44-48	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	69-72
34599990-8	2021	Furthermore, CAP-treated SP-PEI-PPy NP-MC polymeric complexes possessed augmented mechanical properties, biocompatibility, sustainable drug release, drug-retention effects, and near-infrared (NIR)-induced hyperthermia effects that drove heat-shock protein (HSP) expression with drug permeation to deep lesions.	sp-pei	25-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	257-260
35366771-2	2022	Methods- In this research, we developed the amphiphilic Heparin-Poloxamer P403 (HSP) nanogel that can load curcumin (CUR) and Paclitaxel (PTX) through the hydrophobic core of Poloxamer P403.	Heparin	56-63	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
34635886-3	2021	Herein, we developed zeolite-based imidazole framework (ZIF-8)-coated mesoporous polydopamine (MPDA) core-shell nanoparticles and then loaded Pifithrin-mu (PES), a natural inhibitor of heat-shock protein (HSP) that plays an essential role in bacteria resisting heating-induced damage.	Zeolites	21-28	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	185-203
34635886-3	2021	Herein, we developed zeolite-based imidazole framework (ZIF-8)-coated mesoporous polydopamine (MPDA) core-shell nanoparticles and then loaded Pifithrin-mu (PES), a natural inhibitor of heat-shock protein (HSP) that plays an essential role in bacteria resisting heating-induced damage.	Zeolites	21-28	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	205-208
34635886-3	2021	Herein, we developed zeolite-based imidazole framework (ZIF-8)-coated mesoporous polydopamine (MPDA) core-shell nanoparticles and then loaded Pifithrin-mu (PES), a natural inhibitor of heat-shock protein (HSP) that plays an essential role in bacteria resisting heating-induced damage.	pifithrin	142-151	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	185-203
34635886-3	2021	Herein, we developed zeolite-based imidazole framework (ZIF-8)-coated mesoporous polydopamine (MPDA) core-shell nanoparticles and then loaded Pifithrin-mu (PES), a natural inhibitor of heat-shock protein (HSP) that plays an essential role in bacteria resisting heating-induced damage.	pifithrin	142-151	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	205-208
34635886-5	2021	As a result, HSP was remarkably suppressed for enhancing PTT efficacy upon mild near-infrared light irradiation.	Bialaphos	57-60	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	13-16
34668000-5	2021	Additionally, the Zn0.2Fe2.8O4@PDA@MnO2 NPs can significantly consume overexpressed glutathione (GSH) and generate Mn2+ in the tumor microenvironment (TME), thus destroying redox homeostasis and catalytically generating hydroxyl radicals ( OH) for HSP suppression and PTT enhancement.	manganese dioxide	35-39	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	248-251
34668000-5	2021	Additionally, the Zn0.2Fe2.8O4@PDA@MnO2 NPs can significantly consume overexpressed glutathione (GSH) and generate Mn2+ in the tumor microenvironment (TME), thus destroying redox homeostasis and catalytically generating hydroxyl radicals ( OH) for HSP suppression and PTT enhancement.	Glutathione	84-95	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	248-251
34668000-5	2021	Additionally, the Zn0.2Fe2.8O4@PDA@MnO2 NPs can significantly consume overexpressed glutathione (GSH) and generate Mn2+ in the tumor microenvironment (TME), thus destroying redox homeostasis and catalytically generating hydroxyl radicals ( OH) for HSP suppression and PTT enhancement.	Glutathione	97-100	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	248-251
34668000-5	2021	Additionally, the Zn0.2Fe2.8O4@PDA@MnO2 NPs can significantly consume overexpressed glutathione (GSH) and generate Mn2+ in the tumor microenvironment (TME), thus destroying redox homeostasis and catalytically generating hydroxyl radicals ( OH) for HSP suppression and PTT enhancement.	Manganese(2+)	115-119	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	248-251
34668000-5	2021	Additionally, the Zn0.2Fe2.8O4@PDA@MnO2 NPs can significantly consume overexpressed glutathione (GSH) and generate Mn2+ in the tumor microenvironment (TME), thus destroying redox homeostasis and catalytically generating hydroxyl radicals ( OH) for HSP suppression and PTT enhancement.	Hydroxyl Radical	220-237	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	248-251
34241605-5	2021	This biomimetic nanoreactor could not only exhaust endogenous glucose to suppress the growth of the tumor by the released glucose oxidase (GOx), but also enhance the effect of photothermal therapy via inhibiting the expression of heat shock protein (HSP).	Glucose	62-69	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	230-248
34241605-5	2021	This biomimetic nanoreactor could not only exhaust endogenous glucose to suppress the growth of the tumor by the released glucose oxidase (GOx), but also enhance the effect of photothermal therapy via inhibiting the expression of heat shock protein (HSP).	Glucose	62-69	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	250-253
34901547-5	2022	The integrated GOD effectively catalyzes the depletion of glucose for reducing the supplies of adenosine triphosphate (ATP) and subsequent down-regulation of HSP expression.	Glucose	58-65	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	158-161
34901547-5	2022	The integrated GOD effectively catalyzes the depletion of glucose for reducing the supplies of adenosine triphosphate (ATP) and subsequent down-regulation of HSP expression.	Adenosine	95-104	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	158-161
34901547-5	2022	The integrated GOD effectively catalyzes the depletion of glucose for reducing the supplies of adenosine triphosphate (ATP) and subsequent down-regulation of HSP expression.	Adenosine Triphosphate	119-122	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	158-161
34064836-2	2021	Here, we identify a homozygous frameshift alteration occurring in the last coding exon of the protein tyrosine phosphatase type 23 (PTPN23) gene in an extended Palestinian family associated with autosomal recessive complex HSP.	Tyrosine	102-110	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	223-226
35368048-7	2022	c-MYB ablation results from disrupted HSP/HSC70 chaperone protein homeostasis in leukemia cells following induction of proteotoxicity and the unfolded protein response by WFA.	withaferin A	171-174	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	38-41
35442630-7	2022	In vitro experiments showed that PMS could inhibit the expression of heat shock protein (HSP) by damaging the mitochondria, thereby finally improving the effect of mild-temperature PTT.	Bialaphos	181-184	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	69-87
35442630-7	2022	In vitro experiments showed that PMS could inhibit the expression of heat shock protein (HSP) by damaging the mitochondria, thereby finally improving the effect of mild-temperature PTT.	Bialaphos	181-184	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	89-92
34609385-7	2021	The exposed Met elevates the O2 content and reduces ATP production in tumor sites to spur the successful O2-dependent PDT and HSP-mediated PTT.	Adenosine Triphosphate	52-55	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	126-129
34552885-10	2021	Enrichment analysis showed that several upregulated genes in IND patients participate in relevant immunological pathways such as antigen-dependent B cell activation, stress induction of HSP regulation, NO2-dependent IL12 pathway in NK cells, and cytokine-inflammatory response.	indole	61-64	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	186-189
34248662-2	2021	We aimed to clarify the influence of intake of 4 G -alpha-glucopyranosyl hesperidin (G-Hsp) beverage on the lower-leg swelling caused by 6 h of sitting in six healthy women.	g -alpha-glucopyranosyl hesperidin	49-83	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	87-90
34353437-3	2021	The major groups, which are classified based on their molecular weight, include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSP (HSP110 and glucose-regulated protein 170).	Glucose	141-148	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	125-128
35366771-2	2022	Methods- In this research, we developed the amphiphilic Heparin-Poloxamer P403 (HSP) nanogel that can load curcumin (CUR) and Paclitaxel (PTX) through the hydrophobic core of Poloxamer P403.	Curcumin	107-115	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
35366771-2	2022	Methods- In this research, we developed the amphiphilic Heparin-Poloxamer P403 (HSP) nanogel that can load curcumin (CUR) and Paclitaxel (PTX) through the hydrophobic core of Poloxamer P403.	Paclitaxel	126-136	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
35366771-2	2022	Methods- In this research, we developed the amphiphilic Heparin-Poloxamer P403 (HSP) nanogel that can load curcumin (CUR) and Paclitaxel (PTX) through the hydrophobic core of Poloxamer P403.	Paclitaxel	138-141	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
35366771-6	2022	In vitro research confirms lower cytotoxicity of HSP@CUR@PTX compared with free PTX and higher inhibition effect with MCF-7 than HSP@PTX.	Paclitaxel	57-60	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
35366771-6	2022	In vitro research confirms lower cytotoxicity of HSP@CUR@PTX compared with free PTX and higher inhibition effect with MCF-7 than HSP@PTX.	Paclitaxel	80-83	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
35366771-6	2022	In vitro research confirms lower cytotoxicity of HSP@CUR@PTX compared with free PTX and higher inhibition effect with MCF-7 than HSP@PTX.	Paclitaxel	133-136	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	129-132
35366771-8	2022	Conclusion, HSP@CUR@PTX suggests a prominent strategy for achieving the synergistic effect of PTX and CUR to circumvent undesirable effects in breast cancer treatment.	Paclitaxel	20-23	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-15
35366771-8	2022	Conclusion, HSP@CUR@PTX suggests a prominent strategy for achieving the synergistic effect of PTX and CUR to circumvent undesirable effects in breast cancer treatment.	Paclitaxel	94-97	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-15
35387195-7	2022	HSP sows had the lowest plasma urea level at Day 20 compared to LSP and MSP sows (4.0 vs. 5.5 and 4.9 mmol/L, respectively; p < 0.01).	Urea	31-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3