PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32055344-3	2019	To facilitate access to the large proportion of biocatalytically relevant monomeric enzymes, we demonstrate that the tagging valency of the monomeric (S)-stereoselective ketoreductase Gre2p from Saccharomyces cerevisiae can be designed to assemble stable, active hydrogels with the cofactor-regenerating glucose 1-dehydrogenase GDH from Bacillus subtilis.	Glucose	304-311	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	184-189
30027490-0	2018	Expression of Gre2p improves tolerance of engineered xylose-fermenting Saccharomyces cerevisiae to glycolaldehyde under xylose metabolism.	Xylose	53-59	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	14-19
30027490-0	2018	Expression of Gre2p improves tolerance of engineered xylose-fermenting Saccharomyces cerevisiae to glycolaldehyde under xylose metabolism.	glycolaldehyde	99-113	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	14-19
30027490-0	2018	Expression of Gre2p improves tolerance of engineered xylose-fermenting Saccharomyces cerevisiae to glycolaldehyde under xylose metabolism.	Xylose	120-126	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	14-19
30027490-6	2018	We demonstrate that genome integration of an extra copy of autologous GRE2 with its native promotor substantially improved the toxic tolerance of engineered xylose-fermenting S. cerevisiae to major inhibitory compounds including glycolaldehyde in the xylose-containing medium, and xylose-rich, lignocellulosic hydrolysate derived from Miscanthus giganteus, and concurrently improved the ethanol fermentation profile.	Xylose	157-163	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	70-74
30027490-6	2018	We demonstrate that genome integration of an extra copy of autologous GRE2 with its native promotor substantially improved the toxic tolerance of engineered xylose-fermenting S. cerevisiae to major inhibitory compounds including glycolaldehyde in the xylose-containing medium, and xylose-rich, lignocellulosic hydrolysate derived from Miscanthus giganteus, and concurrently improved the ethanol fermentation profile.	glycolaldehyde	229-243	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	70-74
30027490-6	2018	We demonstrate that genome integration of an extra copy of autologous GRE2 with its native promotor substantially improved the toxic tolerance of engineered xylose-fermenting S. cerevisiae to major inhibitory compounds including glycolaldehyde in the xylose-containing medium, and xylose-rich, lignocellulosic hydrolysate derived from Miscanthus giganteus, and concurrently improved the ethanol fermentation profile.	Xylose	251-257	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	70-74
30027490-6	2018	We demonstrate that genome integration of an extra copy of autologous GRE2 with its native promotor substantially improved the toxic tolerance of engineered xylose-fermenting S. cerevisiae to major inhibitory compounds including glycolaldehyde in the xylose-containing medium, and xylose-rich, lignocellulosic hydrolysate derived from Miscanthus giganteus, and concurrently improved the ethanol fermentation profile.	Xylose	251-257	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	70-74
30027490-6	2018	We demonstrate that genome integration of an extra copy of autologous GRE2 with its native promotor substantially improved the toxic tolerance of engineered xylose-fermenting S. cerevisiae to major inhibitory compounds including glycolaldehyde in the xylose-containing medium, and xylose-rich, lignocellulosic hydrolysate derived from Miscanthus giganteus, and concurrently improved the ethanol fermentation profile.	Ethanol	387-394	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	70-74
24879127-1	2014	Saccharomyces cerevisiae Gre2 (EC1.1.1.283) serves as a versatile enzyme that catalyzes the stereoselective reduction of a broad range of substrates including aliphatic and aromatic ketones, diketones, as well as aldehydes, using NADPH as the cofactor.	Ketones	182-189	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	25-29
24879127-1	2014	Saccharomyces cerevisiae Gre2 (EC1.1.1.283) serves as a versatile enzyme that catalyzes the stereoselective reduction of a broad range of substrates including aliphatic and aromatic ketones, diketones, as well as aldehydes, using NADPH as the cofactor.	diketones	191-200	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	25-29
24879127-2	2014	Here we present the crystal structures of Gre2 from S. cerevisiae in an apo-form at 2.00A and NADPH-complexed form at 2.40A resolution.	NADP	94-99	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	42-46
24879127-1	2014	Saccharomyces cerevisiae Gre2 (EC1.1.1.283) serves as a versatile enzyme that catalyzes the stereoselective reduction of a broad range of substrates including aliphatic and aromatic ketones, diketones, as well as aldehydes, using NADPH as the cofactor.	Aldehydes	213-222	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	25-29
24879127-1	2014	Saccharomyces cerevisiae Gre2 (EC1.1.1.283) serves as a versatile enzyme that catalyzes the stereoselective reduction of a broad range of substrates including aliphatic and aromatic ketones, diketones, as well as aldehydes, using NADPH as the cofactor.	NADP	230-235	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	25-29
23744286-7	2013	Genome-wide survey identified GRE2 encoding a NADPH-dependent reductase as the gene that confers tolerance to glycolaldehyde.	glycolaldehyde	110-124	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	30-34
24858409-4	2014	We find that citrinin triggers a fast and dose dependent activation of stress responsive promoters such as GRE2 or SOD2.	Citrinin	13-21	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	107-111
23744286-9	2013	NADPH-dependent glycolaldehyde conversion to ethylene glycol and NADP+ content of the strain overexpressing both ADH1 and GRE2 were increased at 5 mM glycolaldehyde.	glycolaldehyde	150-164	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	122-126
23744286-8	2013	Overexpression of GRE2 in addition to ADH1 further improved the tolerance to glycolaldehyde.	glycolaldehyde	77-91	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	18-22
23744286-10	2013	Expression of GRE2 was increased in response to glycolaldehyde.	glycolaldehyde	48-62	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	14-18
23744286-12	2013	Thus, it was concluded that the overexpression of GRE2 together with ADH1 restores glycolaldehyde tolerance by augmenting the NADPH-dependent reduction pathway in addition to NADH-dependent reduction pathway.	glycolaldehyde	83-97	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	50-54
23744286-9	2013	NADPH-dependent glycolaldehyde conversion to ethylene glycol and NADP+ content of the strain overexpressing both ADH1 and GRE2 were increased at 5 mM glycolaldehyde.	NADP	0-5	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	122-126
23744286-12	2013	Thus, it was concluded that the overexpression of GRE2 together with ADH1 restores glycolaldehyde tolerance by augmenting the NADPH-dependent reduction pathway in addition to NADH-dependent reduction pathway.	NADP	126-131	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	50-54
23744286-9	2013	NADPH-dependent glycolaldehyde conversion to ethylene glycol and NADP+ content of the strain overexpressing both ADH1 and GRE2 were increased at 5 mM glycolaldehyde.	glycolaldehyde	16-30	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	122-126
23744286-12	2013	Thus, it was concluded that the overexpression of GRE2 together with ADH1 restores glycolaldehyde tolerance by augmenting the NADPH-dependent reduction pathway in addition to NADH-dependent reduction pathway.	NAD	175-179	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	50-54
23744286-9	2013	NADPH-dependent glycolaldehyde conversion to ethylene glycol and NADP+ content of the strain overexpressing both ADH1 and GRE2 were increased at 5 mM glycolaldehyde.	Ethylene Glycol	45-60	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	122-126
23744286-9	2013	NADPH-dependent glycolaldehyde conversion to ethylene glycol and NADP+ content of the strain overexpressing both ADH1 and GRE2 were increased at 5 mM glycolaldehyde.	NADP	65-70	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	122-126
20237665-6	2010	As a result, the dehydrogenase Gre2p was shown to be responsible for the majority of the diketone reduction, by comparison to a Gre2p deletion strain lacking activity towards 2,5-hexanedione.	1,4-diselenophene-1,4-diketone	89-97	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	31-36
23530054-3	2013	Specifically, the dose-response behavior of four different natural promoters (GRE2, CTT1, SOD2, and CCP1) reveals differences in their sensitivity and dynamics in response to different salt and oxidative stimuli.	Salts	185-189	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	78-82
22319614-11	2012	GPD1, HSP78, STL1 and GRE2 showed an induction already at 10 min after exposure to salt stress.	Salts	83-87	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	22-26
20237665-6	2010	As a result, the dehydrogenase Gre2p was shown to be responsible for the majority of the diketone reduction, by comparison to a Gre2p deletion strain lacking activity towards 2,5-hexanedione.	2,5-hexanedione	175-190	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	31-36
20237665-6	2010	As a result, the dehydrogenase Gre2p was shown to be responsible for the majority of the diketone reduction, by comparison to a Gre2p deletion strain lacking activity towards 2,5-hexanedione.	2,5-hexanedione	175-190	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	128-133
20237665-9	2010	Michaelis-Menten kinetic studies have shown that Gre2p is capable of catalysing both the reduction of 2,5-hexanedione as well as the oxidation of (2S,5S)-hexanediol, but the catalytic efficiency of the reduction is three times higher.	2,5-hexanedione	102-117	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	49-54
20237665-9	2010	Michaelis-Menten kinetic studies have shown that Gre2p is capable of catalysing both the reduction of 2,5-hexanedione as well as the oxidation of (2S,5S)-hexanediol, but the catalytic efficiency of the reduction is three times higher.	2,5-hexanediol	146-164	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	49-54
22226197-0	2012	Engineered NADH-dependent GRE2 from Saccharomyces cerevisiae by directed enzyme evolution enhances HMF reduction using additional cofactor NADPH.	NAD	11-15	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	26-30
22226197-0	2012	Engineered NADH-dependent GRE2 from Saccharomyces cerevisiae by directed enzyme evolution enhances HMF reduction using additional cofactor NADPH.	NADP	139-144	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	26-30
22226197-3	2012	YOL151W (GRE2) is a commonly recognized up-regulated gene expressed under stress conditions that encodes reductase activities toward furfural and HMF using cofactor NADH.	NAD	165-169	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	9-13
20606287-3	2010	Crystals of a Gre2p complex with NADP(+) were grown using PEG 8000 as a precipitant.	NADP	33-37	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	14-19
20606287-3	2010	Crystals of a Gre2p complex with NADP(+) were grown using PEG 8000 as a precipitant.	polyethylene glycol 8000	58-66	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	14-19
20237665-6	2010	As a result, the dehydrogenase Gre2p was shown to be responsible for the majority of the diketone reduction, by comparison to a Gre2p deletion strain lacking activity towards 2,5-hexanedione.	1,4-diselenophene-1,4-diketone	89-97	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	128-133
16999827-7	2007	Mutants carrying gre2 mutations were derepressed for filament formation and formed large, invasive filaments even in the absence of isoamyl alcohol.	isopentyl alcohol	132-147	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	17-21
16598690-0	2006	Involvement of yeast YOL151W/GRE2 in ergosterol metabolism.	Ergosterol	37-47	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	29-33
16598690-3	2006	Combining quantitative phenotypic profiling and protein expression analysis studies, we here report the involvement of yeast Gre2p in ergosterol metabolism.	Ergosterol	134-144	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	125-130
16598690-6	2006	Involvement of Gre2p in ergosterol metabolism was confirmed by application of an array of selective inhibitors of lipid biosynthesis, as gre2Delta displayed vastly impaired tolerance exclusively to agents targeting the ergosterol biosynthesis.	Ergosterol	24-34	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	15-20
16598690-6	2006	Involvement of Gre2p in ergosterol metabolism was confirmed by application of an array of selective inhibitors of lipid biosynthesis, as gre2Delta displayed vastly impaired tolerance exclusively to agents targeting the ergosterol biosynthesis.	Ergosterol	219-229	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	15-20
12722185-3	2003	We show that methylglyoxal reductase (NADPH-dependent) is encoded by GRE2 (YOL151w).	NADP	38-43	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	69-73