PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31741824-4	2019	Mannose-phosphate-dolichol utilization defect 1 (MPDU1) plays a role in the utilization of DPM.	Dolichol Monophosphate Mannose	0-26	mannose-P-dolichol utilization defect 1	Homo sapiens	49-54
31741824-4	2019	Mannose-phosphate-dolichol utilization defect 1 (MPDU1) plays a role in the utilization of DPM.	Dolichol Monophosphate Mannose	91-94	mannose-P-dolichol utilization defect 1	Homo sapiens	49-54
31741824-5	2019	Here, we report two MPDU1-CDG patients without skin involvement, but with massive dilatation of the biliary duct system and dystroglycanopathy characteristics including hypotonia, elevated creatine kinase, dilated cardiomyopathy, buphthalmos, and congenital glaucoma.	Creatine	189-197	mannose-P-dolichol utilization defect 1	Homo sapiens	20-25
8454645-2	1993	In Lec35.1 CHO mutants, mannose-P-dolichol is synthesized but does not participate in the production of glycosylphosphatidylinositol (GPI) anchor precursors or dolichol-linked oligosaccharides.	CAV protocol	11-14	mannose-P-dolichol utilization defect 1	Homo sapiens	3-8
11733564-6	2001	Sequence analysis of the Lec35/MPDU1 gene, known to be involved in the use of dolichylphosphomannose and dolichylphosphoglucose, revealed mutations in all three patients.	dolichylphosphomannose	78-100	mannose-P-dolichol utilization defect 1	Homo sapiens	25-30
11733564-6	2001	Sequence analysis of the Lec35/MPDU1 gene, known to be involved in the use of dolichylphosphomannose and dolichylphosphoglucose, revealed mutations in all three patients.	dolichylphosphomannose	78-100	mannose-P-dolichol utilization defect 1	Homo sapiens	31-36
11733564-6	2001	Sequence analysis of the Lec35/MPDU1 gene, known to be involved in the use of dolichylphosphomannose and dolichylphosphoglucose, revealed mutations in all three patients.	dolichylphosphoglucose	105-127	mannose-P-dolichol utilization defect 1	Homo sapiens	25-30
11733564-6	2001	Sequence analysis of the Lec35/MPDU1 gene, known to be involved in the use of dolichylphosphomannose and dolichylphosphoglucose, revealed mutations in all three patients.	dolichylphosphoglucose	105-127	mannose-P-dolichol utilization defect 1	Homo sapiens	31-36
11733564-7	2001	Retroviral-based expression of the normal Lec35 cDNA in primary fibroblasts of patients restored normal lipid-linked oligosaccharide biosynthesis.	Oligosaccharides	117-132	mannose-P-dolichol utilization defect 1	Homo sapiens	42-47
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	Mannose	67-74	mannose-P-dolichol utilization defect 1	Homo sapiens	4-9
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	Mannose	67-74	mannose-P-dolichol utilization defect 1	Homo sapiens	24-30
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	127-156	mannose-P-dolichol utilization defect 1	Homo sapiens	4-9
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	127-156	mannose-P-dolichol utilization defect 1	Homo sapiens	24-30
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	158-162	mannose-P-dolichol utilization defect 1	Homo sapiens	4-9
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	158-162	mannose-P-dolichol utilization defect 1	Homo sapiens	24-30
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	Glycosylphosphatidylinositols	168-197	mannose-P-dolichol utilization defect 1	Homo sapiens	4-9
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	Glycosylphosphatidylinositols	168-197	mannose-P-dolichol utilization defect 1	Homo sapiens	24-30
11179430-9	2001	These results show that Lec35p has an essential role for all known classes of monosaccharide-P-dolichol-dependent reactions in mammals.	monosaccharide-p	78-94	mannose-P-dolichol utilization defect 1	Homo sapiens	24-30
11179430-9	2001	These results show that Lec35p has an essential role for all known classes of monosaccharide-P-dolichol-dependent reactions in mammals.	Dolichols	95-103	mannose-P-dolichol utilization defect 1	Homo sapiens	24-30
23694781-3	2013	The mutant cell line was partially defective in MPDU1, which encodes a protein required for the utilization of dolichol-phosphate mannose.	Dolichol Monophosphate Mannose	111-137	mannose-P-dolichol utilization defect 1	Homo sapiens	48-53
17913728-6	2008	By compensatory overexpression of Lec35p, G3M9Gn2-P-P-Dol synthesis in GPT overexpressers could be restored.	g3m9gn2-p-p-dol	42-57	mannose-P-dolichol utilization defect 1	Homo sapiens	34-40
11733556-3	2001	CDG-If is caused by a defect in the gene MPDU1, the human homologue of hamster Lec35, and is the first disorder to affect the use, rather than the biosynthesis, of donor substrates for lipid-linked oligosaccharides.	lipid-linked oligosaccharides	185-214	mannose-P-dolichol utilization defect 1	Homo sapiens	0-6
11733556-3	2001	CDG-If is caused by a defect in the gene MPDU1, the human homologue of hamster Lec35, and is the first disorder to affect the use, rather than the biosynthesis, of donor substrates for lipid-linked oligosaccharides.	lipid-linked oligosaccharides	185-214	mannose-P-dolichol utilization defect 1	Homo sapiens	41-46
8454645-2	1993	In Lec35.1 CHO mutants, mannose-P-dolichol is synthesized but does not participate in the production of glycosylphosphatidylinositol (GPI) anchor precursors or dolichol-linked oligosaccharides.	mannose-p-dolichol	24-42	mannose-P-dolichol utilization defect 1	Homo sapiens	3-8
8454645-10	1993	Interestingly, these results suggest similarities between the Lec35.1 defect and the human disease paroxysmal nocturnal hemoglobinuria, which may involve gradual inactivation of a gene necessary for mannosylation of GPI anchor precursors.	Glycosylphosphatidylinositols	216-219	mannose-P-dolichol utilization defect 1	Homo sapiens	62-67
35279850-7	2022	Moreover, group-specific high-mannose N-glycan signatures were found in ALG3-, ALG9-, ALG11-, ALG12-, RFT1-, SRD5A3-, DOLK-, DPM1-, DPM3-, MPDU1-, ALG13-CDG, and hereditary fructose intolerance.	Mannose	30-37	mannose-P-dolichol utilization defect 1	Homo sapiens	139-144
35279850-7	2022	Moreover, group-specific high-mannose N-glycan signatures were found in ALG3-, ALG9-, ALG11-, ALG12-, RFT1-, SRD5A3-, DOLK-, DPM1-, DPM3-, MPDU1-, ALG13-CDG, and hereditary fructose intolerance.	n-glycan	38-46	mannose-P-dolichol utilization defect 1	Homo sapiens	139-144