PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
26475199-1	2015	Arabidopsis thaliana has four NADP-dependent malic enzymes (NADP-ME 1-4) for reversible malate decarboxylation, with NADP-ME2 being the only cytosolic isoform ubiquitously expressed and responsible for most of the total activity.	NADP	30-34	NADP-malic enzyme 2	Arabidopsis thaliana	117-125
28075062-5	2017	The heterologous expression of NADP-ME1, NADP-ME2 (and its mutant proteins), and NADP-ME3 restored the growth of Pyc- S. cerevisiae on glucose, and this capacity was dependent on the availability of CO2 .	Glucose	135-142	NADP-malic enzyme 2	Arabidopsis thaliana	41-49
28075062-5	2017	The heterologous expression of NADP-ME1, NADP-ME2 (and its mutant proteins), and NADP-ME3 restored the growth of Pyc- S. cerevisiae on glucose, and this capacity was dependent on the availability of CO2 .	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	199-202	NADP-malic enzyme 2	Arabidopsis thaliana	41-49
28075062-7	2017	NADP-ME carboxylation activity could be measured in leaf crude extracts of knockout and overexpressing Arabidopsis lines with modified levels of NADP-ME, where this activity was correlated with the amount of NADP-ME2 transcript.	nadp-me	0-7	NADP-malic enzyme 2	Arabidopsis thaliana	208-216
28075062-7	2017	NADP-ME carboxylation activity could be measured in leaf crude extracts of knockout and overexpressing Arabidopsis lines with modified levels of NADP-ME, where this activity was correlated with the amount of NADP-ME2 transcript.	nadp-me	145-152	NADP-malic enzyme 2	Arabidopsis thaliana	208-216
31581524-6	2019	In vitro assays confirmed that peroxynitrite inhibits cytosolic NADP-ME2 activity due to tyrosine nitration.	Peroxynitrous Acid	31-44	NADP-malic enzyme 2	Arabidopsis thaliana	64-72
31581524-6	2019	In vitro assays confirmed that peroxynitrite inhibits cytosolic NADP-ME2 activity due to tyrosine nitration.	Tyrosine	89-97	NADP-malic enzyme 2	Arabidopsis thaliana	64-72
31581524-7	2019	The mass spectrometric analysis of nitrated NADP-ME2 enabled us to determine that Tyr-73 was exclusively nitrated to 3-nitrotyrosine by peroxynitrite.	tyrosyltyrosine	82-85	NADP-malic enzyme 2	Arabidopsis thaliana	44-52
31581524-7	2019	The mass spectrometric analysis of nitrated NADP-ME2 enabled us to determine that Tyr-73 was exclusively nitrated to 3-nitrotyrosine by peroxynitrite.	3-nitrotyrosine	117-132	NADP-malic enzyme 2	Arabidopsis thaliana	44-52
31581524-7	2019	The mass spectrometric analysis of nitrated NADP-ME2 enabled us to determine that Tyr-73 was exclusively nitrated to 3-nitrotyrosine by peroxynitrite.	Peroxynitrous Acid	136-149	NADP-malic enzyme 2	Arabidopsis thaliana	44-52
31581524-8	2019	The in silico analysis of the Arabidopsis NADP-ME2 protein sequence suggests that Tyr73 nitration could disrupt the interactions between the specific amino acids responsible for protein structure stability.	tyrosyltyrosine	82-85	NADP-malic enzyme 2	Arabidopsis thaliana	42-50
22497207-7	2012	Transient apoplastic reactive oxygen species (ROS) production after elicitation and callose papilla formation after infection were dampened in nadp-me2.	Reactive Oxygen Species	21-44	NADP-malic enzyme 2	Arabidopsis thaliana	143-151
23242919-7	2013	Fumarate produced an increase in NADP-ME2 activity by binding to an allosteric site.	Fumarates	0-8	NADP-malic enzyme 2	Arabidopsis thaliana	33-41
22497207-7	2012	Transient apoplastic reactive oxygen species (ROS) production after elicitation and callose papilla formation after infection were dampened in nadp-me2.	Reactive Oxygen Species	46-49	NADP-malic enzyme 2	Arabidopsis thaliana	143-151
22497207-9	2012	Taken together, our results indicate that NADP-ME2 is an important player in plant basal defence, where it appears to be involved in the generation of ROS.	Reactive Oxygen Species	151-154	NADP-malic enzyme 2	Arabidopsis thaliana	42-50
16113210-5	2005	NADP-ME2 exhibits the highest specific activity, while NADP-ME3 and NADP-ME4 present the highest catalytic efficiency for NADP and malate, respectively.	malic acid	131-137	NADP-malic enzyme 2	Arabidopsis thaliana	0-8
19725876-8	2009	Furthermore, the N-terminal region of NADP-ME2 is necessary for the activation by succinate of the reverse reaction.	Succinic Acid	82-91	NADP-malic enzyme 2	Arabidopsis thaliana	38-46
19725876-9	2009	Overall, the results show that NADP-ME2 and NADP-ME3 are able to distinguish and interact differently with similar C(4) acids as a result of minimal structural differences.	c(4) acids	115-125	NADP-malic enzyme 2	Arabidopsis thaliana	31-39
17245561-4	2007	L) under carbonate (NaHCO3) stress, and identified it as one of the rice NADP-ME genes (we named it NADP-ME2, GenBank accession no.	Carbonates	9-18	NADP-malic enzyme 2	Arabidopsis thaliana	100-108
17245561-4	2007	L) under carbonate (NaHCO3) stress, and identified it as one of the rice NADP-ME genes (we named it NADP-ME2, GenBank accession no.	Sodium Bicarbonate	20-26	NADP-malic enzyme 2	Arabidopsis thaliana	100-108
17245561-7	2007	Expression of NADP-ME2 mRNA in roots was induced by stress from carbonates (NaHCO3 and Na2CO3, NaCl, and environmental pH changes.	Carbonates	64-74	NADP-malic enzyme 2	Arabidopsis thaliana	14-22
17245561-7	2007	Expression of NADP-ME2 mRNA in roots was induced by stress from carbonates (NaHCO3 and Na2CO3, NaCl, and environmental pH changes.	Sodium Bicarbonate	76-82	NADP-malic enzyme 2	Arabidopsis thaliana	14-22
17245561-7	2007	Expression of NADP-ME2 mRNA in roots was induced by stress from carbonates (NaHCO3 and Na2CO3, NaCl, and environmental pH changes.	sodium carbonate	87-93	NADP-malic enzyme 2	Arabidopsis thaliana	14-22
17245561-7	2007	Expression of NADP-ME2 mRNA in roots was induced by stress from carbonates (NaHCO3 and Na2CO3, NaCl, and environmental pH changes.	Sodium Chloride	95-99	NADP-malic enzyme 2	Arabidopsis thaliana	14-22
17245561-8	2007	NADP-ME2 transcripts increased during 72-h exposures to NaHCO3, NaCl, and PEG stresses.	Sodium Bicarbonate	56-62	NADP-malic enzyme 2	Arabidopsis thaliana	0-8
17245561-8	2007	NADP-ME2 transcripts increased during 72-h exposures to NaHCO3, NaCl, and PEG stresses.	Sodium Chloride	64-68	NADP-malic enzyme 2	Arabidopsis thaliana	0-8
17245561-8	2007	NADP-ME2 transcripts increased during 72-h exposures to NaHCO3, NaCl, and PEG stresses.	Polyethylene Glycols	74-77	NADP-malic enzyme 2	Arabidopsis thaliana	0-8
17245561-12	2007	Transgenic Arabidopsis plants over-expressing NADP-ME2 grew well in 1/2 x MS medium with 100 mM NaCl or 4% mannitol, whereas growth of wild-type (WT) Arabidopsis seedlings was strongly inhibited.	Sodium Chloride	96-100	NADP-malic enzyme 2	Arabidopsis thaliana	46-54
17245561-12	2007	Transgenic Arabidopsis plants over-expressing NADP-ME2 grew well in 1/2 x MS medium with 100 mM NaCl or 4% mannitol, whereas growth of wild-type (WT) Arabidopsis seedlings was strongly inhibited.	Mannitol	107-115	NADP-malic enzyme 2	Arabidopsis thaliana	46-54
17245561-14	2007	These results suggest that NADP-ME2 has a role in enhancing tolerance of plants to salt and osmotic stress.	Salts	83-87	NADP-malic enzyme 2	Arabidopsis thaliana	27-35
17848588-5	2007	Analyses of the BR-insensitive mutant bri1-116 and BR-hypersensitive mutant bzr1-1D identified five proteins (PATL1, PATL2, THI1, AtMDAR3, and NADP-ME2) affected both by BR treatment and in the mutants, suggesting their importance in BR action.	Brassinosteroids	51-53	NADP-malic enzyme 2	Arabidopsis thaliana	143-151
23851193-2	2013	This study investigated the response and functional importance of the major leaf cytosolic NADP-malic enzyme in Arabidopsis (NADP-ME2) during oxidative stress.	NADP	91-95	NADP-malic enzyme 2	Arabidopsis thaliana	125-133
34333694-7	2021	NADP-ME2 from Arabidopsis thaliana exhibits a distinctive and complex regulation by fumarate, acting as an activator or an inhibitor according to substrate and effector concentrations.	Fumarates	84-92	NADP-malic enzyme 2	Arabidopsis thaliana	0-8
34333694-10	2021	The regulatory site model and its docking analysis suggested that other C4 acids including malate, NADP-ME2 substrate, could also fit into fumarate"s pocket.	c4 acids	72-80	NADP-malic enzyme 2	Arabidopsis thaliana	99-107
34333694-10	2021	The regulatory site model and its docking analysis suggested that other C4 acids including malate, NADP-ME2 substrate, could also fit into fumarate"s pocket.	malic acid	91-97	NADP-malic enzyme 2	Arabidopsis thaliana	99-107
35276409-0	2022	The receptor-like cytosolic kinase RIPK activates NADP-malic enzyme 2 to generate NADPH for fueling ROS production.	NADP	82-87	NADP-malic enzyme 2	Arabidopsis thaliana	50-69
35276409-0	2022	The receptor-like cytosolic kinase RIPK activates NADP-malic enzyme 2 to generate NADPH for fueling ROS production.	Reactive Oxygen Species	100-103	NADP-malic enzyme 2	Arabidopsis thaliana	50-69
35276409-7	2022	To verify this possibility, we isolated the proteins associated with RPM1-INDUCED PROTEIN KINASE (RIPK), a receptor-like cytoplasmic kinase that regulates broad-spectrum ROS signaling in plant immunity, and identified NADP-malic enzyme 2 (NADP-ME2), an NADPH-generating enzyme.	NADP	253-258	NADP-malic enzyme 2	Arabidopsis thaliana	218-237
35276409-7	2022	To verify this possibility, we isolated the proteins associated with RPM1-INDUCED PROTEIN KINASE (RIPK), a receptor-like cytoplasmic kinase that regulates broad-spectrum ROS signaling in plant immunity, and identified NADP-malic enzyme 2 (NADP-ME2), an NADPH-generating enzyme.	NADP	253-258	NADP-malic enzyme 2	Arabidopsis thaliana	239-247
35276409-8	2022	Compared with wild-type plants, nadp-me2 mutants display decreased NADP-ME activity, lower NADPH levels, and reduced ROS production in response to immune elicitors.	nadp-me	67-74	NADP-malic enzyme 2	Arabidopsis thaliana	32-40
35276409-8	2022	Compared with wild-type plants, nadp-me2 mutants display decreased NADP-ME activity, lower NADPH levels, and reduced ROS production in response to immune elicitors.	NADP	91-96	NADP-malic enzyme 2	Arabidopsis thaliana	32-40
35276409-8	2022	Compared with wild-type plants, nadp-me2 mutants display decreased NADP-ME activity, lower NADPH levels, and reduced ROS production in response to immune elicitors.	Reactive Oxygen Species	117-120	NADP-malic enzyme 2	Arabidopsis thaliana	32-40
35276409-10	2022	The phosphorylation of the NADP-ME2 S371 residue contributes to ROS production upon immune elicitor treatment and susceptibility to the necrotrophic bacterium Pectobacterium carotovorum.	Reactive Oxygen Species	64-67	NADP-malic enzyme 2	Arabidopsis thaliana	27-35
35276409-11	2022	Collectively, our study suggests that RIPK phosphorylates and activates NADP-ME2 to rapidly increase cytosolic NADPH, thus fueling RBOHD to sustain ROS production in plant immunity.	NADP	111-116	NADP-malic enzyme 2	Arabidopsis thaliana	72-80
35276409-11	2022	Collectively, our study suggests that RIPK phosphorylates and activates NADP-ME2 to rapidly increase cytosolic NADPH, thus fueling RBOHD to sustain ROS production in plant immunity.	Reactive Oxygen Species	148-151	NADP-malic enzyme 2	Arabidopsis thaliana	72-80