PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31536952-5	2019	Compound GB14 exhibited significant blood glucose lowering activity and was also found to be active inhibitor of alpha-amylase.	Glucose	42-49	MARVEL domain containing 1	Homo sapiens	9-13
27447558-3	2016	Interference of SREBP1 binding partner MARVELD1 potentiate the therapeutic effect of gefitinib as well.	Gefitinib	85-94	MARVEL domain containing 1	Homo sapiens	39-47
31066116-0	2019	MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system.	Reactive Oxygen Species	45-68	MARVEL domain containing 1	Homo sapiens	0-8
31066116-5	2019	And under cellular stress, the reactive oxygen species (ROS) levels decreased in MARVELD1 expressed cells while increased in the cells of MARVELD1-specific siRNA treatment.	Reactive Oxygen Species	31-54	MARVEL domain containing 1	Homo sapiens	81-89
31066116-5	2019	And under cellular stress, the reactive oxygen species (ROS) levels decreased in MARVELD1 expressed cells while increased in the cells of MARVELD1-specific siRNA treatment.	Reactive Oxygen Species	31-54	MARVEL domain containing 1	Homo sapiens	138-146
31066116-5	2019	And under cellular stress, the reactive oxygen species (ROS) levels decreased in MARVELD1 expressed cells while increased in the cells of MARVELD1-specific siRNA treatment.	Reactive Oxygen Species	56-59	MARVEL domain containing 1	Homo sapiens	81-89
31066116-5	2019	And under cellular stress, the reactive oxygen species (ROS) levels decreased in MARVELD1 expressed cells while increased in the cells of MARVELD1-specific siRNA treatment.	Reactive Oxygen Species	56-59	MARVEL domain containing 1	Homo sapiens	138-146
31066116-6	2019	Meanwhile, MARVELD1 overexpression significantly promoted the inhibition of tumor cell proliferation under cellular stress via affecting ROS metabolism, not cell cycle.	Reactive Oxygen Species	137-140	MARVEL domain containing 1	Homo sapiens	11-19
31066116-7	2019	In xenograft tumor tissues with MARVELD1 expression, the tumor growth was inhibited and accompanied by the lower ROS levels.	Reactive Oxygen Species	113-116	MARVEL domain containing 1	Homo sapiens	32-40
31066116-9	2019	And the enhanced sensitivity to chemotherapeutic drugs clearly depended on the ability of MARVELD1 scavenge the ROS in carcinoma cells of the reproductive system.	Reactive Oxygen Species	112-115	MARVEL domain containing 1	Homo sapiens	90-98
31066116-10	2019	Our findings clearly explain that MARVELD1 may regulate tumor cell proliferation and sensitivity to chemotherapeutic drugs via reducing the exorbitant ROS.	Reactive Oxygen Species	151-154	MARVEL domain containing 1	Homo sapiens	34-42
31066116-11	2019	The mechanism was that MARVELD1 interacted with CAT to maintain latter stability, and then ensure continuous ROS scavenge.	Reactive Oxygen Species	109-112	MARVEL domain containing 1	Homo sapiens	23-31
31205918-0	2019	MARVELD1 attenuates arsenic trioxide-induced apoptosis in liver cancer cells by inhibiting reactive oxygen species production.	Arsenic Trioxide	20-36	MARVEL domain containing 1	Homo sapiens	0-8
31205918-0	2019	MARVELD1 attenuates arsenic trioxide-induced apoptosis in liver cancer cells by inhibiting reactive oxygen species production.	Reactive Oxygen Species	91-114	MARVEL domain containing 1	Homo sapiens	0-8
31205918-10	2019	Results: Here, we show that MARVELD1 enhances the therapeutic effects of epirubicin, while inducing the strong resistance of liver cancer cells to As2O3 treatment.	Epirubicin	73-83	MARVEL domain containing 1	Homo sapiens	28-36
31205918-10	2019	Results: Here, we show that MARVELD1 enhances the therapeutic effects of epirubicin, while inducing the strong resistance of liver cancer cells to As2O3 treatment.	Arsenic Trioxide	147-152	MARVEL domain containing 1	Homo sapiens	28-36
31205918-11	2019	We further demonstrate that the As2O3-induced apoptosis was inhibited by MARVELD1 overexpression (24 h Vector vs. MARVELD1 =30.58% vs. 17.41%, P<0.01; 48 h Vector vs. MARVELD1 =46.50% vs. 21.02%, P<0.01), possibly through inhibiting ROS production by enhancing TRXR1 expression.	Arsenic Trioxide	32-37	MARVEL domain containing 1	Homo sapiens	73-81
31205918-11	2019	We further demonstrate that the As2O3-induced apoptosis was inhibited by MARVELD1 overexpression (24 h Vector vs. MARVELD1 =30.58% vs. 17.41%, P<0.01; 48 h Vector vs. MARVELD1 =46.50% vs. 21.02%, P<0.01), possibly through inhibiting ROS production by enhancing TRXR1 expression.	Arsenic Trioxide	32-37	MARVEL domain containing 1	Homo sapiens	114-122
31205918-11	2019	We further demonstrate that the As2O3-induced apoptosis was inhibited by MARVELD1 overexpression (24 h Vector vs. MARVELD1 =30.58% vs. 17.41%, P<0.01; 48 h Vector vs. MARVELD1 =46.50% vs. 21.02%, P<0.01), possibly through inhibiting ROS production by enhancing TRXR1 expression.	Arsenic Trioxide	32-37	MARVEL domain containing 1	Homo sapiens	114-122
31205918-11	2019	We further demonstrate that the As2O3-induced apoptosis was inhibited by MARVELD1 overexpression (24 h Vector vs. MARVELD1 =30.58% vs. 17.41%, P<0.01; 48 h Vector vs. MARVELD1 =46.50% vs. 21.02%, P<0.01), possibly through inhibiting ROS production by enhancing TRXR1 expression.	Reactive Oxygen Species	239-242	MARVEL domain containing 1	Homo sapiens	73-81
31205918-14	2019	Conclusions: Our data identified a unique role of MARVELD1 in As2O3-induced apoptosis and As2O3 cancer therapy resistance.	Arsenic Trioxide	62-67	MARVEL domain containing 1	Homo sapiens	50-58
31205918-14	2019	Conclusions: Our data identified a unique role of MARVELD1 in As2O3-induced apoptosis and As2O3 cancer therapy resistance.	Arsenic Trioxide	90-95	MARVEL domain containing 1	Homo sapiens	50-58
22320884-4	2012	Furthermore, treatment of MARVELD1 unexpressing Hep3B2.1-7 and PLC/PRF/5 cells with the demethylating agent 5-aza-2" deoxycytidine restored its expression.	Decitabine	108-130	MARVEL domain containing 1	Homo sapiens	26-34
23826386-0	2013	MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1.	Serine	60-66	MARVEL domain containing 1	Homo sapiens	0-8
23826386-5	2013	We also showed that MARVELD1 promotes the dissociation of SMG1 from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5, which is required for ensuing SMG5-mediated exonucleolytic decay.	Serine	105-111	MARVEL domain containing 1	Homo sapiens	20-28
22320884-6	2012	MARVELD1 overexpression could enhance chemosensitivity of HCC cells to epirubicin and 10-hydroxycamptothecin.	Epirubicin	71-81	MARVEL domain containing 1	Homo sapiens	0-8
22320884-6	2012	MARVELD1 overexpression could enhance chemosensitivity of HCC cells to epirubicin and 10-hydroxycamptothecin.	10-hydroxycamptothecin	86-108	MARVEL domain containing 1	Homo sapiens	0-8
34976185-12	2022	With Wnt/beta-catenin activator LiCl treatment, rescue experiments demonstrated that the role of MARVELD1 in colon cancer progression was dependent on the Wnt/beta-catenin pathway.	Lithium Chloride	32-36	MARVEL domain containing 1	Homo sapiens	97-105