PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
9149130-2	1997	In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate.	Lysine	80-86	deoxyhypusine synthase	Mus musculus	18-40
11098085-1	2000	Deoxyhypusine synthase is the key enzyme for modifying a lysine residue to hypusine in the cellular protein eukaryotic initiation factor 5A (eIF-5A).	Lysine	57-63	deoxyhypusine synthase	Mus musculus	0-22
11098085-3	2000	Inhibition of deoxyhypusine synthase by 1-guanidino-7-aminoheptane (GC7) suppresses tumor cell growth.	1-guanidino-7-aminoheptane	40-66	deoxyhypusine synthase	Mus musculus	14-36
11098085-3	2000	Inhibition of deoxyhypusine synthase by 1-guanidino-7-aminoheptane (GC7) suppresses tumor cell growth.	2-(7-aminoheptyl)guanidine	68-71	deoxyhypusine synthase	Mus musculus	14-36
11098085-5	2000	In view of the importance of polyamines in growth regulation and cancer biology, deoxyhypusine synthase has been considered to be a good target for chemotherapeutic drug design.	Polyamines	29-39	deoxyhypusine synthase	Mus musculus	81-103
11098085-6	2000	Using GC7 as a prototype we have synthesized and tested three classes of diamine analogs, namely, guanidino-, pyrimidino-, and hydroxamate derivatives, as potential inhibitors for deoxyhypusine synthase.	Diamines	73-80	deoxyhypusine synthase	Mus musculus	180-202
11098085-6	2000	Using GC7 as a prototype we have synthesized and tested three classes of diamine analogs, namely, guanidino-, pyrimidino-, and hydroxamate derivatives, as potential inhibitors for deoxyhypusine synthase.	guanidino-, pyrimidino-, and hydroxamate	98-138	deoxyhypusine synthase	Mus musculus	180-202
9149130-2	1997	In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate.	Spermidine	128-138	deoxyhypusine synthase	Mus musculus	18-40
9149130-7	1997	The large difference, >30-fold, in hypusine formation activity between these two cells is mainly due to difference in the amount of newly synthesized eIF-5A precursor rather than deoxyhypusine synthase.	hypusine	38-46	deoxyhypusine synthase	Mus musculus	182-204
34216540-4	2021	Polyamines control TH differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid hypusine, and mice in which T cells are deficient for hypusine develop severe intestinal inflammatory disease.	Polyamines	0-10	deoxyhypusine synthase	Mus musculus	66-88
9244184-0	1996	Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture.	N(1)-guanyl-1,7-diaminoheptane	11-39	deoxyhypusine synthase	Mus musculus	57-79
9244184-1	1996	N1-guanyl-1,7-diaminoheptane (GC7) is a potent inhibitor of deoxyhypusine synthase (DHS), the enzyme that catalyzes the first step in the hypusination of eukaryotic translation initiation factor 5A (eIF-5A).	N(1)-guanyl-1,7-diaminoheptane	0-28	deoxyhypusine synthase	Mus musculus	60-82
9244184-1	1996	N1-guanyl-1,7-diaminoheptane (GC7) is a potent inhibitor of deoxyhypusine synthase (DHS), the enzyme that catalyzes the first step in the hypusination of eukaryotic translation initiation factor 5A (eIF-5A).	N(1)-guanyl-1,7-diaminoheptane	0-28	deoxyhypusine synthase	Mus musculus	84-87
9244184-1	1996	N1-guanyl-1,7-diaminoheptane (GC7) is a potent inhibitor of deoxyhypusine synthase (DHS), the enzyme that catalyzes the first step in the hypusination of eukaryotic translation initiation factor 5A (eIF-5A).	2-(7-aminoheptyl)guanidine	30-33	deoxyhypusine synthase	Mus musculus	60-82
9244184-1	1996	N1-guanyl-1,7-diaminoheptane (GC7) is a potent inhibitor of deoxyhypusine synthase (DHS), the enzyme that catalyzes the first step in the hypusination of eukaryotic translation initiation factor 5A (eIF-5A).	2-(7-aminoheptyl)guanidine	30-33	deoxyhypusine synthase	Mus musculus	84-87
9244184-2	1996	Since eIF-5A is the only known cellular substrate for DHS and GC7 has been reported to block the proliferation of CHO cells, it has been suggested that DHS may be a novel target for anti-cancer therapy.	CAV protocol	114-117	deoxyhypusine synthase	Mus musculus	152-155
7980394-7	1994	Exposure of these cells to exogenous spermidine, which is the natural substrate for deoxyhypusine synthase, resulted in a decrease in the unmodified eIF-5A content.	Spermidine	37-47	deoxyhypusine synthase	Mus musculus	84-106
7980394-8	1994	1-Methylspermidine, which was found to be a substrate of deoxyhypusine synthase in vitro, also decreased the levels of unmodified eIF-5A in the AbeAdo-treated cells.	1-methylspermidine	0-18	deoxyhypusine synthase	Mus musculus	57-79
34688659-2	2021	Hypusine is formed exclusively in eIF5A post-translationally via two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH).	hypusine	0-8	deoxyhypusine synthase	Mus musculus	78-100
34688659-2	2021	Hypusine is formed exclusively in eIF5A post-translationally via two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH).	hypusine	0-8	deoxyhypusine synthase	Mus musculus	102-106
34688659-7	2021	On the other hand, the conditional deletion of Dhps or Eif5a by Camk2a promoter-driven Cre expression (postnatal, mainly in the CA1 region of the hippocampus) did not lead to global developmental defects; rather, these knockout animals exhibited severe impairment in spatial learning, contextual learning, and memory when subjected to the Morris Water Maze and a contextual learning test.	Water	346-351	deoxyhypusine synthase	Mus musculus	47-51
8697449-4	1996	Because deoxyhypusine/hypusine formation is one of the most specific polyamine-dependent biochemical events, we decided to use N1-guanyl-1,7-diaminoheptane (GC7), a potent inhibitor for deoxyhypusine synthase, to assess the role of hypusine formation on tumor growth and differentiation.	2-(7-aminoheptyl)guanidine	157-160	deoxyhypusine synthase	Mus musculus	186-208
7792145-7	1995	This novel increase in calcium current via the m4 muscarinic receptor appears to reflect the coupling with an L-type channel of the D class, due to the sensitivity of the L-type calcium conductance to both DHPs and omega-conotoxin, and, thus, is distinct from the skeletal muscle and cardiac L-type channels of the C class previously studied.	Calcium	23-30	deoxyhypusine synthase	Mus musculus	206-210
7792145-7	1995	This novel increase in calcium current via the m4 muscarinic receptor appears to reflect the coupling with an L-type channel of the D class, due to the sensitivity of the L-type calcium conductance to both DHPs and omega-conotoxin, and, thus, is distinct from the skeletal muscle and cardiac L-type channels of the C class previously studied.	Calcium	178-185	deoxyhypusine synthase	Mus musculus	206-210
1445235-7	1992	N-(3-Aminopropyl)-1,4-diamino-cis-but-2-ene, a spermidine analogue that is a substrate for deoxyhypusine synthase, was able to mimic the effects of spermidine in reversing AbeAdo-induced cytostasis.	cis-N-(3-aminopropyl)but-2-ene-1,4-diamine	0-43	deoxyhypusine synthase	Mus musculus	91-113
1445235-7	1992	N-(3-Aminopropyl)-1,4-diamino-cis-but-2-ene, a spermidine analogue that is a substrate for deoxyhypusine synthase, was able to mimic the effects of spermidine in reversing AbeAdo-induced cytostasis.	Spermidine	47-57	deoxyhypusine synthase	Mus musculus	91-113
1445235-7	1992	N-(3-Aminopropyl)-1,4-diamino-cis-but-2-ene, a spermidine analogue that is a substrate for deoxyhypusine synthase, was able to mimic the effects of spermidine in reversing AbeAdo-induced cytostasis.	Spermidine	148-158	deoxyhypusine synthase	Mus musculus	91-113
34496231-2	2021	Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue.	hypusine	95-103	deoxyhypusine synthase	Mus musculus	13-35
34496231-2	2021	Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue.	hypusine	95-103	deoxyhypusine synthase	Mus musculus	37-41
34496231-2	2021	Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue.	hypusine	105-108	deoxyhypusine synthase	Mus musculus	13-35
34496231-2	2021	Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue.	hypusine	105-108	deoxyhypusine synthase	Mus musculus	37-41
34216540-4	2021	Polyamines control TH differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid hypusine, and mice in which T cells are deficient for hypusine develop severe intestinal inflammatory disease.	hypusine	123-131	deoxyhypusine synthase	Mus musculus	66-88
28233679-15	2017	As a continuation of this approach, the current study describes the synthesis of Novel N3 substituted DHPMs with structure similarities to the active DHPs.	n3 substituted dhpms	87-107	deoxyhypusine synthase	Mus musculus	150-154
31796630-1	2019	Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms.	Polyamines	39-59	deoxyhypusine synthase	Mus musculus	0-22
31796630-1	2019	Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms.	Polyamines	39-59	deoxyhypusine synthase	Mus musculus	24-28
31796630-3	2019	We generated a mouse model that enabled the inducible, postnatal deletion of Dhps specifically in postnatal islet beta cells, which function to maintain glucose homeostasis.	Glucose	153-160	deoxyhypusine synthase	Mus musculus	77-81
31796630-7	2019	Our studies reveal a requirement for DHPS in beta cells to link polyamines to mRNA translation to effect facultative cellular proliferation and glucose homeostasis.	Glucose	144-151	deoxyhypusine synthase	Mus musculus	37-41
27612998-5	2017	Pharmacologic targeting of DHPS by N1-guanyl-1,7-diaminoheptane (GC7) or RNA interference-mediated inhibition of DHPS or DOHH induced tolerance to anoxia in immortalized mouse renal proximal cells.	N(1)-guanyl-1,7-diaminoheptane	35-63	deoxyhypusine synthase	Mus musculus	27-31
27299481-1	2016	A water soluble Hantzsch ester derivative of coumarin, DHPS, was synthesized and successfully applied in the fluorescent sensing nitric oxide (NO) in aqueous solution.	Water	2-7	deoxyhypusine synthase	Mus musculus	55-59
27299481-1	2016	A water soluble Hantzsch ester derivative of coumarin, DHPS, was synthesized and successfully applied in the fluorescent sensing nitric oxide (NO) in aqueous solution.	etidin	16-30	deoxyhypusine synthase	Mus musculus	55-59
27299481-1	2016	A water soluble Hantzsch ester derivative of coumarin, DHPS, was synthesized and successfully applied in the fluorescent sensing nitric oxide (NO) in aqueous solution.	coumarin	45-53	deoxyhypusine synthase	Mus musculus	55-59
27299481-1	2016	A water soluble Hantzsch ester derivative of coumarin, DHPS, was synthesized and successfully applied in the fluorescent sensing nitric oxide (NO) in aqueous solution.	Nitric Oxide	129-141	deoxyhypusine synthase	Mus musculus	55-59
27299481-4	2016	The NO-induced aromatization of dihydropyridine in DHPS to pyridine derivative (PYS) proved to be the switching mechanism for the fluorescent sensing process, which was confirmed through spectra characterization and computation study.	1,4-dihydropyridine	32-47	deoxyhypusine synthase	Mus musculus	51-55
27299481-4	2016	The NO-induced aromatization of dihydropyridine in DHPS to pyridine derivative (PYS) proved to be the switching mechanism for the fluorescent sensing process, which was confirmed through spectra characterization and computation study.	pyridine	39-47	deoxyhypusine synthase	Mus musculus	51-55
27097942-1	2016	OBJECTIVE: N1-guanyl-1, 7-diaminoheptane (GC7), an inhibitor of deoxyhypusine synthase has been shown to exhibit significant anti-cancer activity.	N(1)-guanyl-1,7-diaminoheptane	11-40	deoxyhypusine synthase	Mus musculus	64-86
27234899-1	2016	This mini review is devoted to the design and pharmacological studies of novel atypical 1,4-dihydropyridine (DHP) derivatives which differ to a great extent from the traditional DHPs either by lack of neuronal calcium channel blocking activity and/or inability to protect mitochondrial processes.	1,4-dihydropyridine	88-107	deoxyhypusine synthase	Mus musculus	178-182
27234899-1	2016	This mini review is devoted to the design and pharmacological studies of novel atypical 1,4-dihydropyridine (DHP) derivatives which differ to a great extent from the traditional DHPs either by lack of neuronal calcium channel blocking activity and/or inability to protect mitochondrial processes.	1,4-dihydropyridine	109-112	deoxyhypusine synthase	Mus musculus	178-182
27097942-1	2016	OBJECTIVE: N1-guanyl-1, 7-diaminoheptane (GC7), an inhibitor of deoxyhypusine synthase has been shown to exhibit significant anti-cancer activity.	2-(7-aminoheptyl)guanidine	42-45	deoxyhypusine synthase	Mus musculus	64-86
22694849-1	2012	BACKGROUND: Deoxyhypusine synthase (DHS) catalyzes the first step in hypusine biosynthesis of eukaryotic initiation factor 5A (eIF-5A) in Plasmodium falciparum.	hypusine	17-25	deoxyhypusine synthase	Mus musculus	36-39
26037925-3	2015	To establish the hypusine modification system as a novel platform for therapeutic strategies, we aimed to investigate its functional relevance in mammals by generating and using a range of new knock-out mouse models for the hypusine-modifying enzymes deoxyhypusine synthase and deoxyhypusine hydroxylase as well as for the cancer-related isoform eIF-5A2.	hypusine	17-25	deoxyhypusine synthase	Mus musculus	251-273
23846959-7	2014	Animals haploinsufficient for the gene encoding deoxyhypusine synthase were partially protected from hyperglycemia induced by streptozotocin.	Streptozocin	126-140	deoxyhypusine synthase	Mus musculus	48-70
21850436-2	2012	Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH).	hypusine	0-8	deoxyhypusine synthase	Mus musculus	156-178
21850436-2	2012	Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH).	hypusine	0-8	deoxyhypusine synthase	Mus musculus	180-184
21850436-2	2012	Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH).	polyamine spermidine	92-112	deoxyhypusine synthase	Mus musculus	156-178
21850436-2	2012	Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH).	polyamine spermidine	92-112	deoxyhypusine synthase	Mus musculus	180-184
21850436-2	2012	Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH).	Lysine	127-133	deoxyhypusine synthase	Mus musculus	156-178
21850436-2	2012	Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH).	Lysine	127-133	deoxyhypusine synthase	Mus musculus	180-184
11964177-7	2002	The activity of deoxyhypusine synthase, the first enzyme in the formation of active eIF5A, was inhibited by deoxyspergualin in a cell-free system.	gusperimus	108-123	deoxyhypusine synthase	Mus musculus	16-38
16850525-3	2007	The compound N1-guanyl-1,7-diaminoheptane (GC7) is a potent and selective inhibitor of deoxyhypusine synthase, which catalyses the first step of eIF5A hypusination process.	N(1)-guanyl-1,7-diaminoheptane	13-41	deoxyhypusine synthase	Mus musculus	87-109
16850525-3	2007	The compound N1-guanyl-1,7-diaminoheptane (GC7) is a potent and selective inhibitor of deoxyhypusine synthase, which catalyses the first step of eIF5A hypusination process.	2-(7-aminoheptyl)guanidine	43-46	deoxyhypusine synthase	Mus musculus	87-109
21389784-1	2011	Deoxyhypusine synthase (DHS) catalyzes the post-translational formation of the amino acid hypusine.	amino acid hypusine	79-98	deoxyhypusine synthase	Mus musculus	0-22
21389784-1	2011	Deoxyhypusine synthase (DHS) catalyzes the post-translational formation of the amino acid hypusine.	amino acid hypusine	79-98	deoxyhypusine synthase	Mus musculus	24-27