PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23533523-0	2013	Tetrandrine Inhibits the Wnt/ beta -Catenin Signalling Pathway and Alleviates Osteoarthritis: An In Vitro and In Vivo Study.	tetrandrine	0-11	LOC100125986	Oryctolagus cuniculus	30-43
23533523-7	2013	Thus, Tet may play a useful role in the treatment of OA through the Wnt/ beta -catenin signalling pathway and has potential for the treatment of OA.	tet	6-9	LOC100125986	Oryctolagus cuniculus	73-86
31629251-0	2019	Yougui pills exert osteoprotective effects on rabbit steroid-related osteonecrosis of the femoral head by activating beta-catenin.	Steroids	53-60	LOC100125986	Oryctolagus cuniculus	117-129
21222616-4	2011	Here we demonstrate that 5-ASA alters beta-catenin immunocomplex formation by changing complex binding of seven proteins including translation initiation factors eIF4b.	Mesalamine	25-30	LOC100125986	Oryctolagus cuniculus	38-50
20530983-0	2010	2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin pathway in rabbit articular chondrocytes.	Deoxyglucose	0-17	LOC100125986	Oryctolagus cuniculus	54-66
20530983-8	2010	2DG induced dedifferentiation was dependent on activation of beta-catenin, as the 2DG stimulated accumulation of beta-catenin, which is characterized by translocation of beta-catenin into the nucleus determined by immunofluorescence staining and luciferase assay.	Deoxyglucose	0-3	LOC100125986	Oryctolagus cuniculus	61-73
20530983-8	2010	2DG induced dedifferentiation was dependent on activation of beta-catenin, as the 2DG stimulated accumulation of beta-catenin, which is characterized by translocation of beta-catenin into the nucleus determined by immunofluorescence staining and luciferase assay.	Deoxyglucose	0-3	LOC100125986	Oryctolagus cuniculus	113-125
20530983-8	2010	2DG induced dedifferentiation was dependent on activation of beta-catenin, as the 2DG stimulated accumulation of beta-catenin, which is characterized by translocation of beta-catenin into the nucleus determined by immunofluorescence staining and luciferase assay.	Deoxyglucose	0-3	LOC100125986	Oryctolagus cuniculus	113-125
20530983-8	2010	2DG induced dedifferentiation was dependent on activation of beta-catenin, as the 2DG stimulated accumulation of beta-catenin, which is characterized by translocation of beta-catenin into the nucleus determined by immunofluorescence staining and luciferase assay.	Deoxyglucose	82-85	LOC100125986	Oryctolagus cuniculus	61-73
20530983-8	2010	2DG induced dedifferentiation was dependent on activation of beta-catenin, as the 2DG stimulated accumulation of beta-catenin, which is characterized by translocation of beta-catenin into the nucleus determined by immunofluorescence staining and luciferase assay.	Deoxyglucose	82-85	LOC100125986	Oryctolagus cuniculus	113-125
20530983-8	2010	2DG induced dedifferentiation was dependent on activation of beta-catenin, as the 2DG stimulated accumulation of beta-catenin, which is characterized by translocation of beta-catenin into the nucleus determined by immunofluorescence staining and luciferase assay.	Deoxyglucose	82-85	LOC100125986	Oryctolagus cuniculus	113-125
20530983-9	2010	Inhibition of beta-catenin degradation by inhibition of glycogen synthase kinase 3-beta with lithium chloride (LiCl) or inhibition of proteasome with z-Leu-Leu-Leu-CHO (MG132) accelerated the decrease of type II collagen expression in the chondrocytes.	Lithium Chloride	93-109	LOC100125986	Oryctolagus cuniculus	14-26
20530983-9	2010	Inhibition of beta-catenin degradation by inhibition of glycogen synthase kinase 3-beta with lithium chloride (LiCl) or inhibition of proteasome with z-Leu-Leu-Leu-CHO (MG132) accelerated the decrease of type II collagen expression in the chondrocytes.	Lithium Chloride	111-115	LOC100125986	Oryctolagus cuniculus	14-26
20530983-9	2010	Inhibition of beta-catenin degradation by inhibition of glycogen synthase kinase 3-beta with lithium chloride (LiCl) or inhibition of proteasome with z-Leu-Leu-Leu-CHO (MG132) accelerated the decrease of type II collagen expression in the chondrocytes.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	150-167	LOC100125986	Oryctolagus cuniculus	14-26
20530983-9	2010	Inhibition of beta-catenin degradation by inhibition of glycogen synthase kinase 3-beta with lithium chloride (LiCl) or inhibition of proteasome with z-Leu-Leu-Leu-CHO (MG132) accelerated the decrease of type II collagen expression in the chondrocytes.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	169-174	LOC100125986	Oryctolagus cuniculus	14-26
20530983-10	2010	2DG regulated the post-translational level of beta-catenin whereas the transcriptional level of beta-catenin was not altered.	Deoxyglucose	0-3	LOC100125986	Oryctolagus cuniculus	46-58
20530983-11	2010	These results collectively showed that 2DG regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.	Deoxyglucose	39-42	LOC100125986	Oryctolagus cuniculus	75-87
16159822-12	2005	Atorvastatin reduced bone formation, cellular proliferation, and Lrp5/beta-catenin protein levels in the AVs.	Atorvastatin	0-12	LOC100125986	Oryctolagus cuniculus	70-82
31542485-0	2019	Simvastatin induces differentiation in rabbit articular chondrocytes via Wnt/beta-catenin pathway.	Simvastatin	0-11	LOC100125986	Oryctolagus cuniculus	77-89
31829205-3	2019	The modification of the canonical Wnt pathway was achieved through per os administration of lithium carbonate, which is an intracellular inhibitor of glycogen synthase kinase 3-beta (Gsk3-beta) and therefore induces Wnt/beta-catenin signaling.	Lithium Carbonate	92-109	LOC100125986	Oryctolagus cuniculus	220-232
31542485-6	2019	Further, nuclear/cytosol fraction analysis revealed that simvastatin reduced the expression and translocation of beta-catenin into the nucleus from the cytoplasm by approximately 50% compared with that in the control.	Simvastatin	57-68	LOC100125986	Oryctolagus cuniculus	113-125
31542485-8	2019	Simvastatin-induced differentiation was dependent on inactivation of beta-catenin, as simvastatin inhibited accumulation of beta-catenin, which was characterized by translocation of beta-catenin to the nucleus as shown by immunofluorescence staining and the luciferase assay.	Simvastatin	0-11	LOC100125986	Oryctolagus cuniculus	69-81
31542485-8	2019	Simvastatin-induced differentiation was dependent on inactivation of beta-catenin, as simvastatin inhibited accumulation of beta-catenin, which was characterized by translocation of beta-catenin to the nucleus as shown by immunofluorescence staining and the luciferase assay.	Simvastatin	0-11	LOC100125986	Oryctolagus cuniculus	124-136
31542485-8	2019	Simvastatin-induced differentiation was dependent on inactivation of beta-catenin, as simvastatin inhibited accumulation of beta-catenin, which was characterized by translocation of beta-catenin to the nucleus as shown by immunofluorescence staining and the luciferase assay.	Simvastatin	0-11	LOC100125986	Oryctolagus cuniculus	124-136
31542485-8	2019	Simvastatin-induced differentiation was dependent on inactivation of beta-catenin, as simvastatin inhibited accumulation of beta-catenin, which was characterized by translocation of beta-catenin to the nucleus as shown by immunofluorescence staining and the luciferase assay.	Simvastatin	86-97	LOC100125986	Oryctolagus cuniculus	69-81
31542485-8	2019	Simvastatin-induced differentiation was dependent on inactivation of beta-catenin, as simvastatin inhibited accumulation of beta-catenin, which was characterized by translocation of beta-catenin to the nucleus as shown by immunofluorescence staining and the luciferase assay.	Simvastatin	86-97	LOC100125986	Oryctolagus cuniculus	124-136
31542485-8	2019	Simvastatin-induced differentiation was dependent on inactivation of beta-catenin, as simvastatin inhibited accumulation of beta-catenin, which was characterized by translocation of beta-catenin to the nucleus as shown by immunofluorescence staining and the luciferase assay.	Simvastatin	86-97	LOC100125986	Oryctolagus cuniculus	124-136
31542485-11	2019	Our findings demonstrate that simvastatin increases differentiation of rabbit articular chondrocytes via the beta-catenin pathway.	Simvastatin	30-41	LOC100125986	Oryctolagus cuniculus	109-121
31241227-7	2019	These data suggest that Wnt10b could activate the canonical Wnt/beta-catenin signalling pathway to induce DP cells in the Angora rabbit.	dp	106-108	LOC100125986	Oryctolagus cuniculus	64-76
29523929-10	2018	We also found PEMF-induced activation of osteoblastogenesis-related Wnt/beta-catenin signaling in T1DM skeletons, but PEMF did not alter osteoclastogenesis-associated RANKL/RANK signaling gene expression.	pemf	14-18	LOC100125986	Oryctolagus cuniculus	72-84
29705132-13	2018	These results demonstrated, for the first time, OP-D administration alleviated the damaged osteointegration of titanium alloy implants under diabetic conditions by means of inhibiting oxidative stress via a Wnt/beta-catenin-dependent mechanism.	ophiopogonin D	48-52	LOC100125986	Oryctolagus cuniculus	211-223
29886166-0	2018	Attenuation of the degenerative effects of endothelin-1 on cartilaginous end plate cells by the endothelin receptor antagonist BQ-123 via the Wnt/beta-catenin signaling pathway.	cyclo(Trp-Asp-Pro-Val-Leu)	127-133	LOC100125986	Oryctolagus cuniculus	146-158
29886166-15	2018	In addition, ET-1 stimulation increased the expression of beta-catenin, cyclin D1, and Dvl1 in the Wnt/beta-catenin signaling pathway of CECs from degenerated discs and reduced the expression of GSK-3beta, whereas BQ-123 had the opposite effect.	cyclo(Trp-Asp-Pro-Val-Leu)	214-220	LOC100125986	Oryctolagus cuniculus	58-70
29886166-15	2018	In addition, ET-1 stimulation increased the expression of beta-catenin, cyclin D1, and Dvl1 in the Wnt/beta-catenin signaling pathway of CECs from degenerated discs and reduced the expression of GSK-3beta, whereas BQ-123 had the opposite effect.	cyclo(Trp-Asp-Pro-Val-Leu)	214-220	LOC100125986	Oryctolagus cuniculus	103-115
29257271-5	2018	It was observed that naringin markedly inhibited caspase-3 activity, increased runt-related transcription factor 2 and transcription factor sp7 mRNA expression, promoted alkaline phosphatase activity and upregulated collagen I, peroxisome proliferator-activated receptor (PPAR) gamma2, neurogenic locus notch homolog protein (Notch), beta-catenin and phosphorylated-Rac-alpha serine/threonine protein kinase protein expression in the SANFH rabbit.	naringin	21-29	LOC100125986	Oryctolagus cuniculus	334-346
26945831-0	2016	Chondroprotective effects of palmatine on osteoarthritis in vivo and in vitro: A possible mechanism of inhibiting the Wnt/beta-catenin and Hedgehog signaling pathways.	palmatine	29-38	LOC100125986	Oryctolagus cuniculus	122-134
29285071-8	2017	Furthermore, inhibiting beta-catenin signaling with XAV-939 suppressed the BMP-7-mediated changes.	XAV939	52-59	LOC100125986	Oryctolagus cuniculus	24-36
29163181-0	2017	Shengfu Oil Enhances the Healing of Full-Thickness Scalded Skin Accompanying the Differential Regulation of beta-Catenin, Dlk1, and COX-2.	shengfu oil	0-11	LOC100125986	Oryctolagus cuniculus	108-120
29163181-6	2017	The protein expression of beta-catenin and Dlk1 in the Shengfu oil group was higher than that in the sesame oil group in early wound repair, accompanied by the lower expression of COX-2; the protein expression of beta-catenin decreased in the middle of wound healing; the protein expression of beta-catenin and Dlk1 increased at the end of wound healing.	shengfu oil	55-66	LOC100125986	Oryctolagus cuniculus	26-38
29163181-6	2017	The protein expression of beta-catenin and Dlk1 in the Shengfu oil group was higher than that in the sesame oil group in early wound repair, accompanied by the lower expression of COX-2; the protein expression of beta-catenin decreased in the middle of wound healing; the protein expression of beta-catenin and Dlk1 increased at the end of wound healing.	shengfu oil	55-66	LOC100125986	Oryctolagus cuniculus	213-225
29163181-6	2017	The protein expression of beta-catenin and Dlk1 in the Shengfu oil group was higher than that in the sesame oil group in early wound repair, accompanied by the lower expression of COX-2; the protein expression of beta-catenin decreased in the middle of wound healing; the protein expression of beta-catenin and Dlk1 increased at the end of wound healing.	shengfu oil	55-66	LOC100125986	Oryctolagus cuniculus	213-225
29163181-7	2017	These results strongly suggest that Shengfu oil can enhance wound healing by regulating the expression of beta-catenin, Dlk1, and COX-2 due to its excellent anti-inflammatory, analgesic, and antimicrobial activities.	shengfu oil	36-47	LOC100125986	Oryctolagus cuniculus	106-118
29786210-5	2016	Meanwhile, the beta-catenin inhibitors XAV-939 (0, 0.1, and 1.0 mumol/L) was added in group B; at 2 weeks after osteogenic and adipogenic induction, the gene and protein expressions of collagen type I (COL I), osteocalcin (OCN), and peroxisome proliferator activated receptor gamma 2 (PPARgamma-2) were detected by real time PCR and Western blot.	XAV939	39-42	LOC100125986	Oryctolagus cuniculus	15-27
27555216-0	2016	Pulsed electromagnetic fields promote osteogenesis and osseointegration of porous titanium implants in bone defect repair through a Wnt/beta-catenin signaling-associated mechanism.	Titanium	82-90	LOC100125986	Oryctolagus cuniculus	136-148
27555216-7	2016	PEMF-stimulated group exhibited higher Runx2, Wnt1, Lrp6 and beta-catenin protein expressions.	pemf	0-4	LOC100125986	Oryctolagus cuniculus	61-73
27450649-3	2016	The present study aimed to establish a rabbit model and investigate osteogenesis in steroid-induced femoral head osteonecrosis occurring via Cx43/miR-206 and the changes of Wnt/beta-catenin signal pathway-related proteins.	Steroids	84-91	LOC100125986	Oryctolagus cuniculus	177-189
24122419-8	2014	XAV939, a small molecule inhibitor of the Wnt-beta-catenin pathway, suppressed Foxc2-mediated regulation of BMSC differentiation.	XAV939	0-6	LOC100125986	Oryctolagus cuniculus	46-58
25065588-6	2014	We found DHEA decreased the expression of beta-catenin.	Dehydroepiandrosterone	9-13	LOC100125986	Oryctolagus cuniculus	42-54
25065588-8	2014	It turns out the protective effect of DHEA was significantly decreased when Wnt/beta-catenin signaling was activated, while inactivating Wnt/beta-catenin signaling enhanced the effects of DHEA.	Dehydroepiandrosterone	38-42	LOC100125986	Oryctolagus cuniculus	80-92
25065588-9	2014	Therefore, we hypothesize that DHEA probably exerted its chondroprotective effect by regulating Wnt/beta-catenin signaling.	Dehydroepiandrosterone	31-35	LOC100125986	Oryctolagus cuniculus	100-112
25065588-10	2014	Our findings demonstrate the critical role of Wnt/beta-catenin signaling in DHEA-mediated protection against OA.	Dehydroepiandrosterone	76-80	LOC100125986	Oryctolagus cuniculus	50-62
24291646-0	2014	Hyperbaric oxygen promotes osteogenic differentiation of bone marrow stromal cells by regulating Wnt3a/beta-catenin signaling--an in vitro and in vivo study.	Oxygen	11-17	LOC100125986	Oryctolagus cuniculus	103-115
24291646-1	2014	We hypothesized that the effect of hyperbaric oxygen (HBO) on bone formation is increased via osteogenic differentiation of bone marrow stromal cells (BMSCs), which is regulated by Wnt3a/beta-catenin signaling.	Oxygen	46-52	LOC100125986	Oryctolagus cuniculus	187-199