PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31862901-2	2019	Vacuolar storage is achieved through the action of the Zn/Cd transporter HMA3 (Heavy Metal Atpase 3).	Zinc	55-57	heavy metal atpase 3	Arabidopsis thaliana	58-99
31862901-7	2019	We observed significant positive correlations between expression of HMA3 and of genes known to be involved in Zn homeostasis, including ZIP3, ZIP4, MTP1, and bZIP19.	Zinc	110-112	heavy metal atpase 3	Arabidopsis thaliana	68-72
31862901-8	2019	The results support our hypothesis that alteration in the level of function of HMA3 is counterbalanced by the fine regulation of the Zn homeostasis gene network in roots of A. thaliana.	Zinc	133-135	heavy metal atpase 3	Arabidopsis thaliana	79-83
31862901-3	2019	The Col-0 accession has an HMA3 loss-of-function allele resulting in high shoot Cd, when compared to accession CSHL-5 which has a functional allele and low shoot Cd.	Cadmium	80-82	heavy metal atpase 3	Arabidopsis thaliana	27-31
31862901-5	2019	We hypothesize that plants sense changes in cytosolic Zn that are due to variation in HMA3 function, and respond by altering expression of genes related to Zn uptake, transport and compartmentalisation, in order to maintain Zn homeostasis.	Zinc	54-56	heavy metal atpase 3	Arabidopsis thaliana	86-90
19036834-2	2009	In a previous study, we have shown, using heterologous expression in the yeast Saccharomyces cerevisiae, that in the presence of toxic metals, AtHMA3 was able to phenotypically complement the cadmium/lead (Cd/Pb)-hypersensitive strain ycf1 but not the zinc (Zn)-hypersensitive strain zrc1.	Lead	209-211	heavy metal atpase 3	Arabidopsis thaliana	143-149
29667322-5	2018	Further analysis suggested that bHLH104 positively regulates four heavy metal detoxification-associated genes, IREG2, MTP3, HMA3 and NAS4, which play roles in Cd sequestration and tolerance.	Metals	72-77	heavy metal atpase 3	Arabidopsis thaliana	124-128
29667322-5	2018	Further analysis suggested that bHLH104 positively regulates four heavy metal detoxification-associated genes, IREG2, MTP3, HMA3 and NAS4, which play roles in Cd sequestration and tolerance.	Cadmium	159-161	heavy metal atpase 3	Arabidopsis thaliana	124-128
22969436-4	2012	By combining genome-wide association mapping, linkage mapping in an experimental F2 population, and transgenic complementation, we reveal that HMA3 is the sole major locus responsible for the variation in leaf Cd accumulation we observe in this diverse population of A. thaliana accessions.	Cadmium	210-212	heavy metal atpase 3	Arabidopsis thaliana	143-147
22969436-6	2012	Association of these haplotypes with leaf Cd accumulation and genetics complementation experiments indicate that 5 of these haplotypes are active and 5 are inactive, and that elevated leaf Cd accumulation is associated with the reduced function of HMA3 caused by a nonsense mutation and polymorphisms that change two specific amino acids.	Cadmium	42-44	heavy metal atpase 3	Arabidopsis thaliana	248-252
22969436-6	2012	Association of these haplotypes with leaf Cd accumulation and genetics complementation experiments indicate that 5 of these haplotypes are active and 5 are inactive, and that elevated leaf Cd accumulation is associated with the reduced function of HMA3 caused by a nonsense mutation and polymorphisms that change two specific amino acids.	Cadmium	189-191	heavy metal atpase 3	Arabidopsis thaliana	248-252
19036834-1	2009	The Arabidopsis (Arabidopsis thaliana) Heavy Metal Associated3 (AtHMA3) protein belongs to the P1B-2 subgroup of the P-type ATPase family, which is involved in heavy metal transport.	Metals	166-171	heavy metal atpase 3	Arabidopsis thaliana	64-70
19036834-2	2009	In a previous study, we have shown, using heterologous expression in the yeast Saccharomyces cerevisiae, that in the presence of toxic metals, AtHMA3 was able to phenotypically complement the cadmium/lead (Cd/Pb)-hypersensitive strain ycf1 but not the zinc (Zn)-hypersensitive strain zrc1.	Cadmium	192-199	heavy metal atpase 3	Arabidopsis thaliana	143-149
19036834-2	2009	In a previous study, we have shown, using heterologous expression in the yeast Saccharomyces cerevisiae, that in the presence of toxic metals, AtHMA3 was able to phenotypically complement the cadmium/lead (Cd/Pb)-hypersensitive strain ycf1 but not the zinc (Zn)-hypersensitive strain zrc1.	Cadmium	206-208	heavy metal atpase 3	Arabidopsis thaliana	143-149
19036834-2	2009	In a previous study, we have shown, using heterologous expression in the yeast Saccharomyces cerevisiae, that in the presence of toxic metals, AtHMA3 was able to phenotypically complement the cadmium/lead (Cd/Pb)-hypersensitive strain ycf1 but not the zinc (Zn)-hypersensitive strain zrc1.	Zinc	258-260	heavy metal atpase 3	Arabidopsis thaliana	143-149
19036834-4	2009	Confocal imaging in the presence of the Zn/Cd fluorescent probe BTC-5N revealed that AtHMA3 participates in the vacuolar storage of Cd.	Zinc	40-42	heavy metal atpase 3	Arabidopsis thaliana	85-91
19036834-4	2009	Confocal imaging in the presence of the Zn/Cd fluorescent probe BTC-5N revealed that AtHMA3 participates in the vacuolar storage of Cd.	Cadmium	43-45	heavy metal atpase 3	Arabidopsis thaliana	85-91
19036834-4	2009	Confocal imaging in the presence of the Zn/Cd fluorescent probe BTC-5N revealed that AtHMA3 participates in the vacuolar storage of Cd.	btc-5n	64-70	heavy metal atpase 3	Arabidopsis thaliana	85-91
19036834-4	2009	Confocal imaging in the presence of the Zn/Cd fluorescent probe BTC-5N revealed that AtHMA3 participates in the vacuolar storage of Cd.	Cadmium	132-134	heavy metal atpase 3	Arabidopsis thaliana	85-91
19036834-6	2009	Conversely, ectopic overexpression of AtHMA3 improved plant tolerance to Cd, cobalt, Pb, and Zn; Cd accumulation increased by about 2- to 3-fold in plants overexpressing AtHMA3 compared with wild-type plants.	Cadmium	73-75	heavy metal atpase 3	Arabidopsis thaliana	38-44
19036834-6	2009	Conversely, ectopic overexpression of AtHMA3 improved plant tolerance to Cd, cobalt, Pb, and Zn; Cd accumulation increased by about 2- to 3-fold in plants overexpressing AtHMA3 compared with wild-type plants.	Cobalt	77-83	heavy metal atpase 3	Arabidopsis thaliana	38-44
19036834-6	2009	Conversely, ectopic overexpression of AtHMA3 improved plant tolerance to Cd, cobalt, Pb, and Zn; Cd accumulation increased by about 2- to 3-fold in plants overexpressing AtHMA3 compared with wild-type plants.	Lead	85-87	heavy metal atpase 3	Arabidopsis thaliana	38-44
19036834-6	2009	Conversely, ectopic overexpression of AtHMA3 improved plant tolerance to Cd, cobalt, Pb, and Zn; Cd accumulation increased by about 2- to 3-fold in plants overexpressing AtHMA3 compared with wild-type plants.	Zinc	93-95	heavy metal atpase 3	Arabidopsis thaliana	38-44
19036834-6	2009	Conversely, ectopic overexpression of AtHMA3 improved plant tolerance to Cd, cobalt, Pb, and Zn; Cd accumulation increased by about 2- to 3-fold in plants overexpressing AtHMA3 compared with wild-type plants.	Cadmium	97-99	heavy metal atpase 3	Arabidopsis thaliana	38-44
19036834-6	2009	Conversely, ectopic overexpression of AtHMA3 improved plant tolerance to Cd, cobalt, Pb, and Zn; Cd accumulation increased by about 2- to 3-fold in plants overexpressing AtHMA3 compared with wild-type plants.	Cadmium	97-99	heavy metal atpase 3	Arabidopsis thaliana	170-176
19036834-7	2009	Thus, AtHMA3 likely plays a role in the detoxification of biological (Zn) and nonbiological (Cd, cobalt, and Pb) heavy metals by participating in their vacuolar sequestration, an original function for a P1B-2 ATPase in a multicellular eukaryote.	Zinc	70-72	heavy metal atpase 3	Arabidopsis thaliana	6-12
19036834-7	2009	Thus, AtHMA3 likely plays a role in the detoxification of biological (Zn) and nonbiological (Cd, cobalt, and Pb) heavy metals by participating in their vacuolar sequestration, an original function for a P1B-2 ATPase in a multicellular eukaryote.	Cadmium	93-95	heavy metal atpase 3	Arabidopsis thaliana	6-12
19036834-7	2009	Thus, AtHMA3 likely plays a role in the detoxification of biological (Zn) and nonbiological (Cd, cobalt, and Pb) heavy metals by participating in their vacuolar sequestration, an original function for a P1B-2 ATPase in a multicellular eukaryote.	Cobalt	97-103	heavy metal atpase 3	Arabidopsis thaliana	6-12
19036834-7	2009	Thus, AtHMA3 likely plays a role in the detoxification of biological (Zn) and nonbiological (Cd, cobalt, and Pb) heavy metals by participating in their vacuolar sequestration, an original function for a P1B-2 ATPase in a multicellular eukaryote.	Lead	109-111	heavy metal atpase 3	Arabidopsis thaliana	6-12
14690509-6	2004	The identified candidate genes encode proteins closely related to the following A. thaliana proteins: AtZIP6, a putative cellular Zn uptake system and member of the zinc-regulated transporter (ZRT)-iron regulated transporter (IRT)-like protein (ZIP)-family of metal transporters, the putative P-type metal ATPase AtHMA3, the cation diffusion facilitator ZAT/AtCDF1, and the nicotianamine synthase AtNAS3.	Zinc	130-132	heavy metal atpase 3	Arabidopsis thaliana	313-319
15013746-1	2004	The Arabidopsis thaliana AtHMA3 protein belongs to the P(1B)-adenosine triphosphatase (ATPase) transporter family, involved in heavy metal transport.	Metals	133-138	heavy metal atpase 3	Arabidopsis thaliana	25-31
15013746-2	2004	Functional expression of AtHMA3 phenotypically complements the Cd/Pb-hypersensitive yeast strain Deltaycf1, but not the Zn-hypersensitive mutant Deltazrc1.	Cadmium	63-65	heavy metal atpase 3	Arabidopsis thaliana	25-31
15013746-2	2004	Functional expression of AtHMA3 phenotypically complements the Cd/Pb-hypersensitive yeast strain Deltaycf1, but not the Zn-hypersensitive mutant Deltazrc1.	Lead	66-68	heavy metal atpase 3	Arabidopsis thaliana	25-31
15013746-2	2004	Functional expression of AtHMA3 phenotypically complements the Cd/Pb-hypersensitive yeast strain Deltaycf1, but not the Zn-hypersensitive mutant Deltazrc1.	Zinc	120-122	heavy metal atpase 3	Arabidopsis thaliana	25-31
15013746-3	2004	AtHMA3-complemented Deltaycf1 cells accumulate the same amount of cadmium as YCF1-complemented Deltaycf1 cells or wild-type cells, suggesting that AtHMA3 carries out an intracellular sequestration of Cd.	Cadmium	66-73	heavy metal atpase 3	Arabidopsis thaliana	0-6
15013746-3	2004	AtHMA3-complemented Deltaycf1 cells accumulate the same amount of cadmium as YCF1-complemented Deltaycf1 cells or wild-type cells, suggesting that AtHMA3 carries out an intracellular sequestration of Cd.	Cadmium	66-73	heavy metal atpase 3	Arabidopsis thaliana	147-153
15013746-3	2004	AtHMA3-complemented Deltaycf1 cells accumulate the same amount of cadmium as YCF1-complemented Deltaycf1 cells or wild-type cells, suggesting that AtHMA3 carries out an intracellular sequestration of Cd.	Cadmium	200-202	heavy metal atpase 3	Arabidopsis thaliana	0-6
15013746-3	2004	AtHMA3-complemented Deltaycf1 cells accumulate the same amount of cadmium as YCF1-complemented Deltaycf1 cells or wild-type cells, suggesting that AtHMA3 carries out an intracellular sequestration of Cd.	Cadmium	200-202	heavy metal atpase 3	Arabidopsis thaliana	147-153
15013746-4	2004	A mutant of AtHMA3 altered in the P-ATPase phosphorylation domain did not complement Deltaycf1, suggesting that metal transport rather than chelation is involved.	Metals	112-117	heavy metal atpase 3	Arabidopsis thaliana	12-18
15013746-5	2004	The fusion protein AtHMA3::green fluorescent protein (GFP) is localized at the vacuole, consistent with a role in the influx of cadmium into the vacuolar compartment.	Cadmium	128-135	heavy metal atpase 3	Arabidopsis thaliana	19-25