PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
27519943-6	2016	Ipriflavone supplementation in Hbb(Th3+/-) mice failed to alleviate iron overload and was associated with a milder reduction in intestinal ferroportin and a failure to alter the ratio of hepcidin transcript levels to liver iron stores or splenic expression of the hepcidin-regulatory hormone, erythroferrone.	ipriflavone	0-11	hemoglobin beta chain complex	Mus musculus	31-34
27802588-7	2016	The Hbb and Hba, genes with oxygen transport and antioxidant functions, were increased on days 1 and 14.	Oxygen	28-34	hemoglobin beta chain complex	Mus musculus	4-7
29498007-6	2018	Further, we measured the effects of EPO on preventing mitochondrial deficits in the cuprizone toxic demyelinating mouse model of MS. We found that EPO prevented cuprizone-mediated decreases in Hbb, complex III, and NAA.	Cuprizone	161-170	hemoglobin beta chain complex	Mus musculus	193-196
28772282-6	2017	Blocking the oxygen-binding site of HBB reverts the increase of migration and HIF-1alpha upregulation observed in HBB-overexpressing breast cancer cells.	Oxygen	13-19	hemoglobin beta chain complex	Mus musculus	36-39
28772282-6	2017	Blocking the oxygen-binding site of HBB reverts the increase of migration and HIF-1alpha upregulation observed in HBB-overexpressing breast cancer cells.	Oxygen	13-19	hemoglobin beta chain complex	Mus musculus	114-117
27087140-0	2016	Enhancements of the production of bilirubin and the expression of beta-globin by carbon monoxide during erythroid differentiation.	Carbon Monoxide	81-96	hemoglobin beta chain complex	Mus musculus	66-77
25557851-5	2015	We demonstrate that the total body iron burden is markedly improved in Hbb(th3/+) animals treated with siRNA and chelated with oral deferiprone, representing a significant improvement compared to either compound alone.	Iron	35-39	hemoglobin beta chain complex	Mus musculus	71-74
25616571-7	2015	Mice with the Hbb(th3/+) phenotype have mild to moderate anemia and consistent tissue iron accumulation in the spleen, liver, kidneys and myocardium.	Iron	86-90	hemoglobin beta chain complex	Mus musculus	14-17
25557851-5	2015	We demonstrate that the total body iron burden is markedly improved in Hbb(th3/+) animals treated with siRNA and chelated with oral deferiprone, representing a significant improvement compared to either compound alone.	Deferiprone	132-143	hemoglobin beta chain complex	Mus musculus	71-74
24880340-6	2014	ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease.	Iron	154-158	hemoglobin beta chain complex	Mus musculus	40-43
23223430-5	2013	In the present study, we demonstrate that LNP-Tmprss6 siRNA treatment of Hfe(-/-) and Hbb(th3/+) mice induces hepcidin and diminishes tissue and serum iron levels.	Iron	151-155	hemoglobin beta chain complex	Mus musculus	86-89
24795345-4	2014	In addition, treatment of Hbb(th1/th1) mice with RAP-536 reduced alpha-globin aggregates in peripheral red cells, decreased the elevated reactive oxygen species present in erythroid precursors and peripheral red cells, and alleviated anemia by promoting differentiation of late-stage erythroid precursors and reducing hemolysis.	Reactive Oxygen Species	137-160	hemoglobin beta chain complex	Mus musculus	26-29
24932233-4	2014	Following sodium butyrate (SB) induction, murine erythroleukemia (MEL) cells began to re-enter erythroid differentiation and the ratio of differentiated cells reached ~80% at 72 h. The erythroid maturation-related mRNA expression of alpha-globin, beta-globin and glycophorin A (GPA) was increased markedly, which indicated that SB induced MEL differentiation.	Butyric Acid	27-29	hemoglobin beta chain complex	Mus musculus	247-258
24610531-1	2014	When erythrocyte hemoglobin (Hb) is fully saturated with O2, nitric oxide (NO) covalently binds to the cysteine 93 residue of the Hb beta-chain (B93-CYS), forming S-nitrosohemoglobin.	Oxygen	57-59	hemoglobin beta chain complex	Mus musculus	130-137
24610531-1	2014	When erythrocyte hemoglobin (Hb) is fully saturated with O2, nitric oxide (NO) covalently binds to the cysteine 93 residue of the Hb beta-chain (B93-CYS), forming S-nitrosohemoglobin.	Nitric Oxide	61-73	hemoglobin beta chain complex	Mus musculus	130-137
24610531-1	2014	When erythrocyte hemoglobin (Hb) is fully saturated with O2, nitric oxide (NO) covalently binds to the cysteine 93 residue of the Hb beta-chain (B93-CYS), forming S-nitrosohemoglobin.	Cysteine	103-111	hemoglobin beta chain complex	Mus musculus	130-137
24610531-1	2014	When erythrocyte hemoglobin (Hb) is fully saturated with O2, nitric oxide (NO) covalently binds to the cysteine 93 residue of the Hb beta-chain (B93-CYS), forming S-nitrosohemoglobin.	Cysteine	149-152	hemoglobin beta chain complex	Mus musculus	130-137
24610531-1	2014	When erythrocyte hemoglobin (Hb) is fully saturated with O2, nitric oxide (NO) covalently binds to the cysteine 93 residue of the Hb beta-chain (B93-CYS), forming S-nitrosohemoglobin.	Sulfur	151-152	hemoglobin beta chain complex	Mus musculus	130-137
19546033-3	2009	Hbb haplotype can be readily determined in all strains based on characteristic differences in peak profiles or on peak mobility shift induced by thiol exchange with glutathione disulfide in vitro.	Sulfhydryl Compounds	145-150	hemoglobin beta chain complex	Mus musculus	0-3
20561915-3	2010	To understand the order of the various changes accompanying transcriptional activation, we analyzed the mouse beta globin gene, which is transcriptionally inducible in erythroid MEL cells over a time course of HMBA treatment.	hexamethylene bisacetamide	210-214	hemoglobin beta chain complex	Mus musculus	110-121
22490684-4	2012	Here, we show that homozygous loss of Tmprss6 in Hbb(th3/+) mice improves anemia and reduces ineffective erythropoiesis, splenomegaly, and iron loading.	Iron	139-143	hemoglobin beta chain complex	Mus musculus	49-52
20100937-5	2010	The main objectives of this study were (i) to characterize patterns of nucleotide polymorphism and linkage disequilibrium in the duplicated beta-globin genes of M. castaneus, (ii) to test the hypothesis that the Hbb(d) and Hbb(p) haplotypes are maintained as a balanced polymorphism, and (iii) to assess whether allelic differences in the alternative minor Hb isoforms (d(minor) and p(minor)) are associated with different O(2)-binding properties.	o(2)	423-427	hemoglobin beta chain complex	Mus musculus	212-215
19546033-3	2009	Hbb haplotype can be readily determined in all strains based on characteristic differences in peak profiles or on peak mobility shift induced by thiol exchange with glutathione disulfide in vitro.	Glutathione Disulfide	165-186	hemoglobin beta chain complex	Mus musculus	0-3
17327478-0	2007	Genetic variation in mouse beta globin cysteine content modifies glutathione metabolism: implications for the use of mouse models.	Cysteine	39-47	hemoglobin beta chain complex	Mus musculus	27-38
19059700-4	2009	Our preliminary data demonstrates that Hbb(th1/th1) mice, a model of beta-thalassemia intermedia, have lower bone marrow iron levels while levels in the liver and spleen are increased; the later account for the increased systemic iron burden in beta-thalassemia intermedia.	Iron	121-125	hemoglobin beta chain complex	Mus musculus	39-42
19059700-4	2009	Our preliminary data demonstrates that Hbb(th1/th1) mice, a model of beta-thalassemia intermedia, have lower bone marrow iron levels while levels in the liver and spleen are increased; the later account for the increased systemic iron burden in beta-thalassemia intermedia.	Iron	230-234	hemoglobin beta chain complex	Mus musculus	39-42
19059700-6	2009	MATERIALS AND METHODS: We investigate parameters involved in red cell production, precursor apoptosis, parenchymal iron distribution, and hepcidin expression in iron treated Hbb(th1/th1) mice.	Iron	161-165	hemoglobin beta chain complex	Mus musculus	174-177
17607360-1	2007	Erythrocyte precursors produce abundant alpha- and beta-globin proteins, which assemble with each other to form hemoglobin A (HbA), the major blood oxygen carrier.	Oxygen	148-154	hemoglobin beta chain complex	Mus musculus	51-62
17327478-0	2007	Genetic variation in mouse beta globin cysteine content modifies glutathione metabolism: implications for the use of mouse models.	Glutathione	65-76	hemoglobin beta chain complex	Mus musculus	27-38
17327478-8	2007	The stepwise increase in beta globin sulfhydryl group concentration in HbbS/S, HbbS/D, and HbbD/D F2 mice was associated with increasing hemoglobin-bound glutathione and decreasing free glutathione (GSH + GSSG) concentrations.	Glutathione	154-165	hemoglobin beta chain complex	Mus musculus	25-36
17327478-8	2007	The stepwise increase in beta globin sulfhydryl group concentration in HbbS/S, HbbS/D, and HbbD/D F2 mice was associated with increasing hemoglobin-bound glutathione and decreasing free glutathione (GSH + GSSG) concentrations.	Glutathione	186-197	hemoglobin beta chain complex	Mus musculus	25-36
17327478-8	2007	The stepwise increase in beta globin sulfhydryl group concentration in HbbS/S, HbbS/D, and HbbD/D F2 mice was associated with increasing hemoglobin-bound glutathione and decreasing free glutathione (GSH + GSSG) concentrations.	Glutathione	199-202	hemoglobin beta chain complex	Mus musculus	25-36
17327478-8	2007	The stepwise increase in beta globin sulfhydryl group concentration in HbbS/S, HbbS/D, and HbbD/D F2 mice was associated with increasing hemoglobin-bound glutathione and decreasing free glutathione (GSH + GSSG) concentrations.	Glutathione Disulfide	205-209	hemoglobin beta chain complex	Mus musculus	25-36
17018382-9	2006	RESULTS: Hemoglobin, hematocrit and mean corpuscular volume were significantly reduced in both beta-thalassemia models, more significantly in Hbb(th/3+), which have the greater, age-dependent, iron overload.	Iron	193-197	hemoglobin beta chain complex	Mus musculus	142-145
16948057-4	2006	The effect of REC-1001 on modulating radiation-induced DNA damage was determined in murine thymocytes by measuring nonspecific nuclear DNA damage at the whole genome level using the alkaline halo assay and by measuring sequence/gene-specific DNA damage both in nuclear DNA (beta-globin gene) and in mitochondrial DNA using a quantitative polymerase chain reaction.	rec-1001	14-22	hemoglobin beta chain complex	Mus musculus	274-285
11523594-3	2001	No DNA damage was observed in a nuclear gene (beta-globin) in response to hydrogen peroxide treatment.	Hydrogen Peroxide	74-91	hemoglobin beta chain complex	Mus musculus	46-57
10224267-0	1999	N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations.	Ethylnitrosourea	0-21	hemoglobin beta chain complex	Mus musculus	72-75
9171106-4	1997	Within the transactivation domain, two discrete proline-rich regions were required for rescue of beta-globin expression.	Proline	48-55	hemoglobin beta chain complex	Mus musculus	97-108
8833147-4	1996	By combining the data from the two crosses, the most likely gene order on mouse chromosome 7 is centromere-Hbb-tub-Pth-Calc, thus making it likely that the human homolog of tub resides on 17p15, where the gene order HBB-PTH-CALC is conserved.	pth	115-118	hemoglobin beta chain complex	Mus musculus	107-110
8307327-0	1993	Deletion mapping of four loci defined by N-ethyl-N-nitrosourea-induced postimplantation-lethal mutations within the pid-Hbb region of mouse chromosome 7.	Ethylnitrosourea	41-62	hemoglobin beta chain complex	Mus musculus	120-123
8098217-8	1993	Thus, inheritance of at least one C57L allele at the albino or Hbb loci was associated with protection against MNU-induced lymphoma development.	Methylnitrosourea	111-114	hemoglobin beta chain complex	Mus musculus	63-66
2436752-0	1987	Altered expression of beta-globin, transferrin receptor, and ornithine decarboxylase in Friend murine erythroleukemia cells inhibited by alpha-difluoromethylornithine.	Eflornithine	137-166	hemoglobin beta chain complex	Mus musculus	22-33
1427042-3	1992	The variant beta-globin, (beta s2) of the Hbbs2 haplotype, also had an elevated oxygen affinity and in addition was moderately unstable in 19% isopropanol.	Oxygen	80-86	hemoglobin beta chain complex	Mus musculus	12-23
1427042-3	1992	The variant beta-globin, (beta s2) of the Hbbs2 haplotype, also had an elevated oxygen affinity and in addition was moderately unstable in 19% isopropanol.	2-Propanol	143-154	hemoglobin beta chain complex	Mus musculus	12-23
1954037-2	1991	The electrophoretic mobility of the major component of the new Hbb was identical to that of Hbbs on cellulose acetate plate, although it was almost identical to that of Hbbd or Hbbp on acrylamide gel.	acetylcellulose	100-117	hemoglobin beta chain complex	Mus musculus	63-66
1954037-2	1991	The electrophoretic mobility of the major component of the new Hbb was identical to that of Hbbs on cellulose acetate plate, although it was almost identical to that of Hbbd or Hbbp on acrylamide gel.	Acrylamide	185-195	hemoglobin beta chain complex	Mus musculus	63-66
1598216-0	1992	Bipartite structure of the downstream element of the mouse beta globin (major) poly(A) signal.	Poly A	79-86	hemoglobin beta chain complex	Mus musculus	59-78
2766045-2	1989	In some of the transformants, expression of the endogenous beta-globin gene was only weakly induced with the addition of DMSO, while expression of the introduced beta-globin/TK chimeric gene was well induced.	Dimethyl Sulfoxide	121-125	hemoglobin beta chain complex	Mus musculus	59-70
7110170-0	1982	Genetic analysis of an N-ethyl-N-nitrosourea-induced mutation at the hemoglobin beta-chain locus in mice.	Ethylnitrosourea	23-44	hemoglobin beta chain complex	Mus musculus	69-90
3856518-8	1985	The inhibitory effect of the oxidizing agent on beta-globin mRNA transport could be reversed by postincubation of the nuclei with the reducing agent, dithiothreitol.	Dithiothreitol	150-164	hemoglobin beta chain complex	Mus musculus	48-59
6095210-1	1984	Transcription of RNA from the beta-globin (major) gene in nuclei from induced mouse erythroleukemia cells terminates within the region between 700 to 2000 bases downstream from the poly(A) addition site, but not at particularly favored sites.	Poly A	181-188	hemoglobin beta chain complex	Mus musculus	43-48
3447002-5	1987	Hybridization of one of the two Mus pseudogenes, Hbb-bh3, to genomic blots from Peromyscus reveals that it has a homologous counterpart in Peromyscus.	BH 3	53-56	hemoglobin beta chain complex	Mus musculus	49-52
3767977-1	1986	3H-leucine was used in vitro to label newly synthesized adult alpha and beta globins in reticulocytes removed from normal (Hba-b/Hba-b;Hbb-s2/Hbb-s2 and alpha-thalassemic (Hba-b2(th)/Hba-b;Hbb-s2/Hbb-s2) mice.	DL-Leucine	0-10	hemoglobin beta chain complex	Mus musculus	135-138
3767977-1	1986	3H-leucine was used in vitro to label newly synthesized adult alpha and beta globins in reticulocytes removed from normal (Hba-b/Hba-b;Hbb-s2/Hbb-s2 and alpha-thalassemic (Hba-b2(th)/Hba-b;Hbb-s2/Hbb-s2) mice.	DL-Leucine	0-10	hemoglobin beta chain complex	Mus musculus	142-145
3767977-1	1986	3H-leucine was used in vitro to label newly synthesized adult alpha and beta globins in reticulocytes removed from normal (Hba-b/Hba-b;Hbb-s2/Hbb-s2 and alpha-thalassemic (Hba-b2(th)/Hba-b;Hbb-s2/Hbb-s2) mice.	DL-Leucine	0-10	hemoglobin beta chain complex	Mus musculus	142-145
3767977-1	1986	3H-leucine was used in vitro to label newly synthesized adult alpha and beta globins in reticulocytes removed from normal (Hba-b/Hba-b;Hbb-s2/Hbb-s2 and alpha-thalassemic (Hba-b2(th)/Hba-b;Hbb-s2/Hbb-s2) mice.	DL-Leucine	0-10	hemoglobin beta chain complex	Mus musculus	142-145
6136977-2	1983	This report is an attempt to correlate genotypic fluctuations at Hbb with a most important physiological attribute of haemoglobin, its oxygen carrying capacity.	Oxygen	135-141	hemoglobin beta chain complex	Mus musculus	65-68
6136977-6	1983	In general, the blood of mice of inbred strains as well as wild-caught mice that are homozygous for Hbbd tends to have a higher oxygen affinity than that from comparable animals homozygous for Hbbs, but it seems likely that the oxygen dissociation properties of haemoglobin are not the only ones important in determining differential survival of a particular Hbb type under varying environmental stress.	Oxygen	128-134	hemoglobin beta chain complex	Mus musculus	100-103
6136977-6	1983	In general, the blood of mice of inbred strains as well as wild-caught mice that are homozygous for Hbbd tends to have a higher oxygen affinity than that from comparable animals homozygous for Hbbs, but it seems likely that the oxygen dissociation properties of haemoglobin are not the only ones important in determining differential survival of a particular Hbb type under varying environmental stress.	Oxygen	228-234	hemoglobin beta chain complex	Mus musculus	100-103
33646305-9	2021	In vivo HSC transduction after mobilization with MGTA-145+plerixafor in a mouse model for thalassemia resulted in >95% human gamma-globin+ erythrocytes at a level of 36% of mouse beta-globin.	plerixafor	58-68	hemoglobin beta chain complex	Mus musculus	179-190
728059-0	1978	Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine.	Cystamine	61-70	hemoglobin beta chain complex	Mus musculus	39-42
999642-5	1976	Certain other strains have a singlet allele, Hbb(s), that produces only one beta chain, betas.	betas	88-93	hemoglobin beta chain complex	Mus musculus	45-48
849244-4	1977	However, the minor electrophoretic bands of Hbb-p and Hbb-d react with approximately twice as much maleate as the major bands of each of these hemoglobins, although the minor bands like the major contain only one free cysteine group per beta chain.	maleic acid	99-106	hemoglobin beta chain complex	Mus musculus	44-47
849244-4	1977	However, the minor electrophoretic bands of Hbb-p and Hbb-d react with approximately twice as much maleate as the major bands of each of these hemoglobins, although the minor bands like the major contain only one free cysteine group per beta chain.	maleic acid	99-106	hemoglobin beta chain complex	Mus musculus	54-57
849244-4	1977	However, the minor electrophoretic bands of Hbb-p and Hbb-d react with approximately twice as much maleate as the major bands of each of these hemoglobins, although the minor bands like the major contain only one free cysteine group per beta chain.	Cysteine	218-226	hemoglobin beta chain complex	Mus musculus	44-47
849244-5	1977	This can be explained by the alkylation of the epsilon-amino of lysine residue beta76, but some evidence for the alkylation of histidine in the minor band of Hbb-p is also presented.	Histidine	127-136	hemoglobin beta chain complex	Mus musculus	158-161
33646305-9	2021	In vivo HSC transduction after mobilization with MGTA-145+plerixafor in a mouse model for thalassemia resulted in >95% human gamma-globin+ erythrocytes at a level of 36% of mouse beta-globin.	mgta-145	49-57	hemoglobin beta chain complex	Mus musculus	179-190
33180328-1	2021	beta-thalassemias result from mutations in beta-globin, causing ineffective erythropoiesis and secondary iron overload due to inappropriately low levels of the iron regulatory hormone hepcidin.	Iron	105-109	hemoglobin beta chain complex	Mus musculus	43-54
33180328-1	2021	beta-thalassemias result from mutations in beta-globin, causing ineffective erythropoiesis and secondary iron overload due to inappropriately low levels of the iron regulatory hormone hepcidin.	Iron	160-164	hemoglobin beta chain complex	Mus musculus	43-54
33174016-7	2020	HBL and HBB increased the expression of heme oxygenase-1 (HO-1) protein by inducing the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) through the activation of the reactive oxygen species (ROS)/p38 pathway; the reduction in inducible nitric oxide synthase (iNOS) and interleukin-1beta (IL-1beta) expression by HBL and HBB was inhibited by HO-1 knockdown.	Reactive Oxygen Species	193-216	hemoglobin beta chain complex	Mus musculus	8-11
33174016-7	2020	HBL and HBB increased the expression of heme oxygenase-1 (HO-1) protein by inducing the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) through the activation of the reactive oxygen species (ROS)/p38 pathway; the reduction in inducible nitric oxide synthase (iNOS) and interleukin-1beta (IL-1beta) expression by HBL and HBB was inhibited by HO-1 knockdown.	Reactive Oxygen Species	193-216	hemoglobin beta chain complex	Mus musculus	347-350
33174016-7	2020	HBL and HBB increased the expression of heme oxygenase-1 (HO-1) protein by inducing the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) through the activation of the reactive oxygen species (ROS)/p38 pathway; the reduction in inducible nitric oxide synthase (iNOS) and interleukin-1beta (IL-1beta) expression by HBL and HBB was inhibited by HO-1 knockdown.	Reactive Oxygen Species	218-221	hemoglobin beta chain complex	Mus musculus	8-11
33174016-7	2020	HBL and HBB increased the expression of heme oxygenase-1 (HO-1) protein by inducing the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) through the activation of the reactive oxygen species (ROS)/p38 pathway; the reduction in inducible nitric oxide synthase (iNOS) and interleukin-1beta (IL-1beta) expression by HBL and HBB was inhibited by HO-1 knockdown.	Reactive Oxygen Species	218-221	hemoglobin beta chain complex	Mus musculus	347-350
33174016-9	2020	Collectively, HBL and HBB inhibited LPS-induced nuclear factor-kappaB activation by blocking the nuclear accumulation of p65, increasing HO-1 expression through activation of the ROS/p38/Nrf2 pathway, and increasing ATF3 expression.	Reactive Oxygen Species	179-182	hemoglobin beta chain complex	Mus musculus	22-25