PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 18502200-6 2008 Herein, we report the identification of two conserved motifs critical for chromatin-binding: the first leucine Zip motif (Zip1) of a leucine Zip/Basic/leucine Zip region (ZBZ) previously thought to be a nuclear localization signal (NLS), and a cysteine-rich (CR) motif within the C-terminal region of Kif4A. Cysteine 244-252 solute carrier family 39 member 1 Homo sapiens 122-126 17635580-6 2007 Substitutions of alanines for the di-leucine residues (LL148,149/AA) severely impaired the internalization of ZIP1 and subsequent protein degradation, leading to an accumulation of the mutant ZIP1 on the cell surface, as well as inside the cell. Alanine 17-25 solute carrier family 39 member 1 Homo sapiens 110-114 17635580-6 2007 Substitutions of alanines for the di-leucine residues (LL148,149/AA) severely impaired the internalization of ZIP1 and subsequent protein degradation, leading to an accumulation of the mutant ZIP1 on the cell surface, as well as inside the cell. Alanine 17-25 solute carrier family 39 member 1 Homo sapiens 192-196 17635580-6 2007 Substitutions of alanines for the di-leucine residues (LL148,149/AA) severely impaired the internalization of ZIP1 and subsequent protein degradation, leading to an accumulation of the mutant ZIP1 on the cell surface, as well as inside the cell. di-leucine 34-44 solute carrier family 39 member 1 Homo sapiens 110-114 17635580-6 2007 Substitutions of alanines for the di-leucine residues (LL148,149/AA) severely impaired the internalization of ZIP1 and subsequent protein degradation, leading to an accumulation of the mutant ZIP1 on the cell surface, as well as inside the cell. di-leucine 34-44 solute carrier family 39 member 1 Homo sapiens 192-196 16844077-0 2006 Histidine residues in the region between transmembrane domains III and IV of hZip1 are required for zinc transport across the plasma membrane in PC-3 cells. Histidine 0-9 solute carrier family 39 member 1 Homo sapiens 77-82 16203195-10 2006 An adenoviral-mediated overexpression of ZIP1 in MSCs resulted in Alizarin-red-positive mineralization and also increased expression of specific osteoblast-associated markers, such as alkaline phosphatase, and of several osteoblast differentiation genes, including osteopontin, Cbfa1/Runx2, promyelocytic leukemia zinc finger and bone sialoprotein. alizarin 66-78 solute carrier family 39 member 1 Homo sapiens 41-45 15226459-7 2004 After administration of a zinc supplement (22 mg zinc gluconate/d for 27 d), ZIP1 expression decreased by 17% (P < 0.01) and 21% (P < 0.05) in the peripheral leukocytes collected from 15 young (20-25 y) and 10 elderly (64-75 y) subjects, respectively. gluconic acid 49-63 solute carrier family 39 member 1 Homo sapiens 77-81 16183033-7 2005 The IC50 for proton effects was close to the pKa for histidine, suggesting conserved histidine residues present in SLC39A1 play a critical role in Zn2+ influx and are involved in the pH effect. Histidine 53-62 solute carrier family 39 member 1 Homo sapiens 115-122 16183033-7 2005 The IC50 for proton effects was close to the pKa for histidine, suggesting conserved histidine residues present in SLC39A1 play a critical role in Zn2+ influx and are involved in the pH effect. Histidine 85-94 solute carrier family 39 member 1 Homo sapiens 115-122 16183033-7 2005 The IC50 for proton effects was close to the pKa for histidine, suggesting conserved histidine residues present in SLC39A1 play a critical role in Zn2+ influx and are involved in the pH effect. Zinc 147-151 solute carrier family 39 member 1 Homo sapiens 115-122 12888280-8 2003 Down-regulation of hZIP1 by treatment of PC-3 cells with hZIP1 antisense oligonucleotide resulted in a decreased zinc uptake. Oligonucleotides 73-88 solute carrier family 39 member 1 Homo sapiens 19-24 12888280-8 2003 Down-regulation of hZIP1 by treatment of PC-3 cells with hZIP1 antisense oligonucleotide resulted in a decreased zinc uptake. Oligonucleotides 73-88 solute carrier family 39 member 1 Homo sapiens 57-62 11301334-4 2001 First, we examined (65)Zn uptake activity in K562 erythroleukemia cells overexpressing hZIP1. Zinc 23-25 solute carrier family 39 member 1 Homo sapiens 87-92 11301334-9 2001 Furthermore, hZIP1-dependent (65)Zn uptake was biochemically indistinguishable from the endogenous activity. Zinc 33-35 solute carrier family 39 member 1 Homo sapiens 13-18 11301334-10 2001 Finally, inhibition of endogenous hZIP1 expression with antisense oligonucleotides caused a marked decrease in endogenous (65)Zn uptake activity. Oligonucleotides 66-82 solute carrier family 39 member 1 Homo sapiens 34-39 11301334-10 2001 Finally, inhibition of endogenous hZIP1 expression with antisense oligonucleotides caused a marked decrease in endogenous (65)Zn uptake activity. Zinc 126-128 solute carrier family 39 member 1 Homo sapiens 34-39 35211427-12 2022 GSEA analysis demonstrated that SLC39A1 overexpression was involved in various tumor-related pathways, such as the cell cycle and Wnt signaling pathway. gsea 0-4 solute carrier family 39 member 1 Homo sapiens 32-39 34615436-1 2021 Solute carrier family 39, member 1 (SLC39A1) is a member of the zinc-iron permease family and located to the cell membrane, acting as a zinc uptake transporter. Iron 69-73 solute carrier family 39 member 1 Homo sapiens 0-34 34615436-1 2021 Solute carrier family 39, member 1 (SLC39A1) is a member of the zinc-iron permease family and located to the cell membrane, acting as a zinc uptake transporter. Iron 69-73 solute carrier family 39 member 1 Homo sapiens 36-43 30397150-4 2018 This hyperplastic/inflammatory prostate has a human prostate cancer-like microRNA profile, with up-regulation of the Zn-homeostasis-regulating miR-183-96-182 cluster (fold change = 1.41-2.38; P = 0.029-0.0003) and down-regulation of the Zn importer ZIP1 (target of miR-182), leading to a reduction of prostatic Zn. Zinc 117-119 solute carrier family 39 member 1 Homo sapiens 249-253 30581142-3 2019 Here, we found that MMP is reduced focally at a fission site by the Drp1 recruitment, which is initiated by the interaction of Drp1 with mitochondrial zinc transporter Zip1 and Zn2+ entry through the Zip1-MCU complex. Zinc 177-181 solute carrier family 39 member 1 Homo sapiens 200-204 30828702-10 2019 Clioquinol (zinc ionophore; 5-chloro-7-iodoquinolin-8-ol) is employed to facilitate zinc transport and accumulation in the ZIP1-deficient malignant cells and induce cytotoxic effects. Clioquinol 0-10 solute carrier family 39 member 1 Homo sapiens 123-127 30828702-10 2019 Clioquinol (zinc ionophore; 5-chloro-7-iodoquinolin-8-ol) is employed to facilitate zinc transport and accumulation in the ZIP1-deficient malignant cells and induce cytotoxic effects. Clioquinol 28-56 solute carrier family 39 member 1 Homo sapiens 123-127 30397150-5 2018 This inverse relationship between miR-182 and ZIP1 also occurs in human prostate cancer tissue, which is known for Zn loss. Zinc 115-117 solute carrier family 39 member 1 Homo sapiens 46-50 30397150-6 2018 The discovery that the Zn-depleted middle-aged rat prostate has a metabolic phenotype resembling that of human prostate cancer, with a 10-fold down-regulation of citric acid (P = 0.0003), links citrate reduction directly to prostatic Zn loss, providing the underlying mechanism linking dietary Zn deficiency with miR-183-96-182 overexpression, ZIP1 down-regulation, prostatic Zn loss, and the resultant citrate down-regulation, changes mimicking features of human prostate cancer. Zinc 23-25 solute carrier family 39 member 1 Homo sapiens 344-348 30397150-6 2018 The discovery that the Zn-depleted middle-aged rat prostate has a metabolic phenotype resembling that of human prostate cancer, with a 10-fold down-regulation of citric acid (P = 0.0003), links citrate reduction directly to prostatic Zn loss, providing the underlying mechanism linking dietary Zn deficiency with miR-183-96-182 overexpression, ZIP1 down-regulation, prostatic Zn loss, and the resultant citrate down-regulation, changes mimicking features of human prostate cancer. Citric Acid 194-201 solute carrier family 39 member 1 Homo sapiens 344-348 29952128-3 2018 Many of these proteins (including ZIP1, 2, 3, 4, 5, 6/10, 8, 9, 11, 12, 14) are situated, at least some of the time, on the plasma membrane, where they mediate metal ion uptake into cells. Metals 160-165 solute carrier family 39 member 1 Homo sapiens 34-62 25162517-4 2014 In addition, we used Western blotting and RT-PCR to examine the time-dependent changes in expression of proteins regulated by MTF-1 in response to Zn treatment, including the metal binding protein MT-1, the zinc efflux protein ZnT-1, and the zinc influx regulator ZIP-1. Zinc 147-149 solute carrier family 39 member 1 Homo sapiens 264-269 30093983-6 2018 Citrate production, along with growth and proliferation by these cells, is regulated by co-existing testosterone and prolactin signaling pathways; and by the oncogenic down-regulation of ZIP1 transporter/zinc/citrate in the development of malignancy. Citric Acid 0-7 solute carrier family 39 member 1 Homo sapiens 187-191 30093983-6 2018 Citrate production, along with growth and proliferation by these cells, is regulated by co-existing testosterone and prolactin signaling pathways; and by the oncogenic down-regulation of ZIP1 transporter/zinc/citrate in the development of malignancy. Citric Acid 209-216 solute carrier family 39 member 1 Homo sapiens 187-191 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 16-20 solute carrier family 39 member 1 Homo sapiens 93-97 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 16-20 solute carrier family 39 member 1 Homo sapiens 167-171 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 64-68 solute carrier family 39 member 1 Homo sapiens 93-97 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 64-68 solute carrier family 39 member 1 Homo sapiens 167-171 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 64-68 solute carrier family 39 member 1 Homo sapiens 93-97 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 64-68 solute carrier family 39 member 1 Homo sapiens 167-171 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Citric Acid 245-252 solute carrier family 39 member 1 Homo sapiens 93-97 28515164-9 2017 Furthermore, mRNA expression of ZIP1 was 85% lower in the PE+MMN group than in the PE group (P = 0.003).Conclusion: In conditions of low maternal iron and in the absence of supplemental zinc, the placenta upregulates the gene expression of iron and zinc uptake proteins, presumably in order to meet fetal demands in the face of low maternal supply. Iron 146-150 solute carrier family 39 member 1 Homo sapiens 32-36 28515164-9 2017 Furthermore, mRNA expression of ZIP1 was 85% lower in the PE+MMN group than in the PE group (P = 0.003).Conclusion: In conditions of low maternal iron and in the absence of supplemental zinc, the placenta upregulates the gene expression of iron and zinc uptake proteins, presumably in order to meet fetal demands in the face of low maternal supply. Iron 240-244 solute carrier family 39 member 1 Homo sapiens 32-36 26013661-5 2015 The binding between miR-133 and predicted target SLC39A1 was verified using dual luciferase assay and Western blot analysis. mir-133 20-27 solute carrier family 39 member 1 Homo sapiens 49-56 26013661-9 2015 SLC39A1 showed an inverse expression trend to miR-133 during the differentiation. mir-133 46-53 solute carrier family 39 member 1 Homo sapiens 0-7 26013661-15 2015 MiR-133 can induce postmenopausal osteoporosis by weakening osteogenic differentiation of hMSCs, at least partly through repressing SLC39A1 expression. mir-133 0-7 solute carrier family 39 member 1 Homo sapiens 132-139 26635961-11 2015 This was accompanied by increased ZIP1 transporter, which is an essential genetic/metabolic event for citrate-producing cells. Citric Acid 102-109 solute carrier family 39 member 1 Homo sapiens 34-38 26905204-5 2016 Real time PCR analyses of 14 ZIP (solute-linked carrier (SLC) SLC39A; Zrt/IRT-like protein), and 9 ZnT (SLC30A) zinc transporters revealed significantly enhanced mRNA expression of the zinc importer ZIP1 after AZA treatment. Decitabine 210-213 solute carrier family 39 member 1 Homo sapiens 199-203 26905204-6 2016 Because ZIP1 protein was also enhanced after AZA treatment, ZIP1 up-regulation might be the mediator of enhanced intracellular zinc levels. Decitabine 45-48 solute carrier family 39 member 1 Homo sapiens 8-12 26905204-6 2016 Because ZIP1 protein was also enhanced after AZA treatment, ZIP1 up-regulation might be the mediator of enhanced intracellular zinc levels. Decitabine 45-48 solute carrier family 39 member 1 Homo sapiens 60-64 25755079-8 2015 Both MT1A and ZIP1 expression showed a significant increase in the Zn supplemented group (p < 0.05). Zinc 67-69 solute carrier family 39 member 1 Homo sapiens 14-18 22610605-0 2012 Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Cadmium 0-7 solute carrier family 39 member 1 Homo sapiens 63-67 25745519-8 2014 The up-regulation of zinc uptake transporter ZIP1 is essential for the manifestation of the citrate-producing capability of the osteoblasts. Citric Acid 92-99 solute carrier family 39 member 1 Homo sapiens 45-49 22610605-5 2012 The bZIP transcription factor Zip1, which is functionally related to human Nrf2 and S. cerevisiae Met4, has a smaller effect on cadmium-induced proteome remodeling, but it is required for production of key proteins involved in sulfur metabolism, which are essential for cadmium resistance. Sulfur 227-233 solute carrier family 39 member 1 Homo sapiens 30-34 23378263-9 2013 Functional studies to establish a role for hZip1 in cellular zinc accumulation were carried out using (65)Zn. Zinc 106-108 solute carrier family 39 member 1 Homo sapiens 43-48 23064315-4 2012 The aim of this study was to determine the expression levels of selected miRNA and zinc(II)-related genes (ZIP-1, BAX, MT2A and MT1A) in the non-tumor PNT1A prostate cell line in comparison with the prostate cancer cell lines 22Rv1, PC-3 and LNCaP after zinc(II) treatment. Zinc 95-103 solute carrier family 39 member 1 Homo sapiens 131-136 23064315-4 2012 The aim of this study was to determine the expression levels of selected miRNA and zinc(II)-related genes (ZIP-1, BAX, MT2A and MT1A) in the non-tumor PNT1A prostate cell line in comparison with the prostate cancer cell lines 22Rv1, PC-3 and LNCaP after zinc(II) treatment. Zinc 290-298 solute carrier family 39 member 1 Homo sapiens 131-136 22610605-5 2012 The bZIP transcription factor Zip1, which is functionally related to human Nrf2 and S. cerevisiae Met4, has a smaller effect on cadmium-induced proteome remodeling, but it is required for production of key proteins involved in sulfur metabolism, which are essential for cadmium resistance. Cadmium 128-135 solute carrier family 39 member 1 Homo sapiens 30-34 22570624-4 2012 Using a genetically tractable Drosophila model, we found that the expression of dZip1, the orthologue of human Slc39 family transporter hZip1 in Drosophila, was altered in the brains of Abeta42-expressing flies, and Zn homeostasis could be modulated by forcible dZip1 expression changes. Zinc 216-218 solute carrier family 39 member 1 Homo sapiens 136-141 22610605-5 2012 The bZIP transcription factor Zip1, which is functionally related to human Nrf2 and S. cerevisiae Met4, has a smaller effect on cadmium-induced proteome remodeling, but it is required for production of key proteins involved in sulfur metabolism, which are essential for cadmium resistance. Cadmium 270-277 solute carrier family 39 member 1 Homo sapiens 30-34 22610605-6 2012 These studies reveal how Spc1 and Zip1 independently reshape the proteome to modulate cellular defense mechanisms against the toxic effects of cadmium. Cadmium 143-150 solute carrier family 39 member 1 Homo sapiens 34-38 21940908-4 2011 In this report, we demonstrate an increase in hZip1 and hZip3 zinc transporters" expression and zinc uptake by the prostate cancer cells DU-145 and LNCaP in response to 5-aza-2"-deoxycytidine. Decitabine 169-191 solute carrier family 39 member 1 Homo sapiens 46-51 20957409-2 2011 The influence of zinc and zinc chelator (TPEN) on transcription levels of the main zinc transporters (ZnT1 and ZIP1) in the HT-29 colorectal cell line has not been reported. N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine 41-45 solute carrier family 39 member 1 Homo sapiens 111-115 22253048-6 2011 Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake. Nickel 115-121 solute carrier family 39 member 1 Homo sapiens 36-41 22253048-6 2011 Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake. Nickel 115-121 solute carrier family 39 member 1 Homo sapiens 169-173 22253048-6 2011 Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake. Zinc 227-229 solute carrier family 39 member 1 Homo sapiens 36-41 22253048-6 2011 Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake. Zinc 227-229 solute carrier family 39 member 1 Homo sapiens 169-173 22253048-10 2011 These findings demonstrate that ZIP1-mediated uptake of zinc induces ATP release and autocrine/paracrine activation of P2X(7) receptors, and then activates microglia, suggesting that zinc transporter-mediated uptake of zinc is a trigger for microglial activation via the NADPH oxidase and PARP-1 pathway. Adenosine Triphosphate 69-72 solute carrier family 39 member 1 Homo sapiens 32-36 21360563-6 2011 Prostate TMAs and tissue sections showed an inverse relationship between RREB-1 and hZIP1 staining. tmas 9-13 solute carrier family 39 member 1 Homo sapiens 84-89 21633338-6 2011 We found that intra-BLA but not central nucleus of the amygdala injection of the selective PKMzeta inhibitor ZIP 1 day after CPP and CPA training impaired the expression of CPP and CPA 1 day later, and the effect of ZIP on memory lasted at least 2 weeks. pkmzeta 91-98 solute carrier family 39 member 1 Homo sapiens 109-114 20471814-7 2011 Concurrently, GSPE and EGCG inhibit the expression, evaluated at the mRNA level by quantitative reverse transcriptase-polymerase chain reaction, of zinc-binding metallothioneins and of plasma membrane zinc exporter ZnT1 (SLC30A1), while enhancing the expression of cellular zinc importers ZIP1 (SLC39A1) and ZIP4 (SLC39A4). epigallocatechin gallate 23-27 solute carrier family 39 member 1 Homo sapiens 289-293 20471814-7 2011 Concurrently, GSPE and EGCG inhibit the expression, evaluated at the mRNA level by quantitative reverse transcriptase-polymerase chain reaction, of zinc-binding metallothioneins and of plasma membrane zinc exporter ZnT1 (SLC30A1), while enhancing the expression of cellular zinc importers ZIP1 (SLC39A1) and ZIP4 (SLC39A4). epigallocatechin gallate 23-27 solute carrier family 39 member 1 Homo sapiens 295-302 20705137-7 2010 Here we report a new method to show a differential Zn staining method that correlates with various stages of prostate cancer development in situ and expression of a human Zn transporter1-hZIP1 -in situ by in situ reverse transcriptase-polymerase chain reaction hybridization (ISRTPCR) that correlate with the relative Zn levels determined by the differential Zn staining method. Zinc 51-53 solute carrier family 39 member 1 Homo sapiens 187-192 20705137-7 2010 Here we report a new method to show a differential Zn staining method that correlates with various stages of prostate cancer development in situ and expression of a human Zn transporter1-hZIP1 -in situ by in situ reverse transcriptase-polymerase chain reaction hybridization (ISRTPCR) that correlate with the relative Zn levels determined by the differential Zn staining method. Zinc 171-173 solute carrier family 39 member 1 Homo sapiens 187-192 20705137-7 2010 Here we report a new method to show a differential Zn staining method that correlates with various stages of prostate cancer development in situ and expression of a human Zn transporter1-hZIP1 -in situ by in situ reverse transcriptase-polymerase chain reaction hybridization (ISRTPCR) that correlate with the relative Zn levels determined by the differential Zn staining method. Zinc 171-173 solute carrier family 39 member 1 Homo sapiens 187-192