PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2511200-5	1989	Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone.	Tetradecanoylphorbol Acetate	19-44	interleukin 1 beta	Homo sapiens	184-193
2511200-5	1989	Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone.	Tetradecanoylphorbol Acetate	46-49	interleukin 1 beta	Homo sapiens	184-193
2511200-5	1989	Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone.	Tetradecanoylphorbol Acetate	233-236	interleukin 1 beta	Homo sapiens	184-193
2511200-13	1989	The present findings thus suggest: 1) that TPA induces LPS responsiveness in U937 cells via de novo synthesis of Gi2; 2) that the LPS response (enhanced IL-1 production) is linked to a pertussis toxin-sensitive G protein which we identified as Gi2; and 3) that LPS leads to phosphorylation of Gi2.	Tetradecanoylphorbol Acetate	43-46	interleukin 1 beta	Homo sapiens	153-157
2514105-9	1989	Indomethacin present during stimulation of PBMC increased the amount of IL 1 beta produced and showed a high correlation (R = 0.83) compared to cultures without indomethacin.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	72-81
2484061-3	1989	Results showed that when activated with lipopolysaccharide (LPS) or desmethyl muramyl dipeptide (norMDP), AM released much less extracellular IL-1 beta than did blood monocytes.	N-acetyl-demethylmuramyl-alanyl-isoglutamine	68-95	interleukin 1 beta	Homo sapiens	142-151
2611121-1	1989	Recombinant human interleukin 1 beta (IL-1 beta), given intraperitoneally to mice as a single injection, significantly suppressed the development of arachidonic acid (AA)-induced ear oedema.	Arachidonic Acid	149-165	interleukin 1 beta	Homo sapiens	18-36
2611121-1	1989	Recombinant human interleukin 1 beta (IL-1 beta), given intraperitoneally to mice as a single injection, significantly suppressed the development of arachidonic acid (AA)-induced ear oedema.	Arachidonic Acid	149-165	interleukin 1 beta	Homo sapiens	38-47
2514105-9	1989	Indomethacin present during stimulation of PBMC increased the amount of IL 1 beta produced and showed a high correlation (R = 0.83) compared to cultures without indomethacin.	PBMC	43-47	interleukin 1 beta	Homo sapiens	72-81
2555138-12	1989	Purified human IL-1 (75% beta, 25% alpha) as well as recombinant human IL-1 beta at concentrations as low as 50 pg/ml inhibited AII-induced aldosterone synthesis.	Aldosterone	140-151	interleukin 1 beta	Homo sapiens	15-19
2555138-12	1989	Purified human IL-1 (75% beta, 25% alpha) as well as recombinant human IL-1 beta at concentrations as low as 50 pg/ml inhibited AII-induced aldosterone synthesis.	Aldosterone	140-151	interleukin 1 beta	Homo sapiens	71-80
2555138-15	1989	Therefore, local or systemically produced TNF or IL-1 may be important negative modulators of aldosterone synthesis.	Aldosterone	94-105	interleukin 1 beta	Homo sapiens	49-53
2511244-7	1989	Cycloheximide (CHX) was able to induce IL-1 mRNA but did not induce transcription of either IL-1 gene.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	39-43
2584355-0	1989	Progesterone and estradiol modulate interleukin-1 beta messenger ribonucleic acid levels in cultured human peripheral monocytes.	Progesterone	0-12	interleukin 1 beta	Homo sapiens	36-54
2584355-0	1989	Progesterone and estradiol modulate interleukin-1 beta messenger ribonucleic acid levels in cultured human peripheral monocytes.	Estradiol	17-26	interleukin 1 beta	Homo sapiens	36-54
2511244-7	1989	Cycloheximide (CHX) was able to induce IL-1 mRNA but did not induce transcription of either IL-1 gene.	Cycloheximide	15-18	interleukin 1 beta	Homo sapiens	39-43
2584355-2	1989	IL-1, a protein secreted by peripheral monocytes and tissue macrophages, mediates a wide variety of immune responses, and its production appears to be inversely related to the level of gonadal steroids.	Steroids	193-201	interleukin 1 beta	Homo sapiens	0-4
2584705-6	1989	LPS induction of IL-1 beta mRNA in human monocytes can be blocked by either an inhibitor of protein kinase C (PKc) 1-(5-isoquinolinesulfonyl)-2-methylpiperazine or an inhibitor of calcium/calmodulin (CaM) kinase N-(6-aminohexyl) 5-chloro-1-naphthalenesulfonamide, suggesting that both PKc and CaM kinase are involved in transducing signals initiated by LPS.	(5-isoquinolinesulfonyl)-2-methylpiperazine	117-160	interleukin 1 beta	Homo sapiens	17-26
2584355-3	1989	In this report, we have investigated the relationship between estradiol and progesterone concentrations and the level of IL-1 beta mRNA in cultured human peripheral monocytes and pelvic macrophages.	Estradiol	62-71	interleukin 1 beta	Homo sapiens	121-130
2584355-6	1989	Hybridization with 32P-labeled probe showed maximal levels of IL-1 beta mRNA occurring between 3 and 7 h of culture.	Phosphorus-32	19-22	interleukin 1 beta	Homo sapiens	62-71
2584355-8	1989	In both cases, IL-1 beta mRNA levels decreased by 80-90% as the progesterone concentration increased to 10(-5) M and by 70-90% as the estradiol concentration increased similarly.	Progesterone	64-76	interleukin 1 beta	Homo sapiens	15-24
2584355-9	1989	A similar 80% decrease in IL-1 beta mRNA was observed with peritoneal macrophages incubated with increasing amounts of progesterone.	Progesterone	119-131	interleukin 1 beta	Homo sapiens	26-35
2584355-10	1989	This reciprocal relationship between IL-1 beta mRNA and gonadal steroids may have important ramifications in reproductive biology for both embryonic implantation and fetal survival as well as for clinically relevant changes in bone mass.	Steroids	64-72	interleukin 1 beta	Homo sapiens	37-46
2584705-6	1989	LPS induction of IL-1 beta mRNA in human monocytes can be blocked by either an inhibitor of protein kinase C (PKc) 1-(5-isoquinolinesulfonyl)-2-methylpiperazine or an inhibitor of calcium/calmodulin (CaM) kinase N-(6-aminohexyl) 5-chloro-1-naphthalenesulfonamide, suggesting that both PKc and CaM kinase are involved in transducing signals initiated by LPS.	W 7	212-262	interleukin 1 beta	Homo sapiens	17-26
2584705-7	1989	In contrast, IL-2 induction of IL-1 beta mRNA expression is blocked only by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, suggesting that PKc, and not CaM kinase, is activated by IL-2.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	76-121	interleukin 1 beta	Homo sapiens	31-40
2629459-4	1989	In a separate series of experiments, treatments of endothelial cells with interleukin 1 beta and tumor necrosis factor alpha, physiological mediators of immunologic and inflammatory responses, were shown to cause an inhibition of the synthesis of endothelial cell surface heparan sulfate.	Heparitin Sulfate	272-287	interleukin 1 beta	Homo sapiens	74-124
2686646-1	1989	The role of calcium in interleukin- (IL) 8-, IL-1 alpha- and IL-1 beta-induced lymphocyte migration has been investigated by using the calcium channel antagonists, verapamil, nifedipine, diltiazem (IL-8) and the optical isomers of the dihydropyridine analogue SDZ 202-791 (IL-8, IL-1 alpha and IL-1 beta).	Calcium	12-19	interleukin 1 beta	Homo sapiens	61-70
2556147-0	1989	Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phosphoinositides metabolism.	Phosphatidylinositols	72-89	interleukin 1 beta	Homo sapiens	0-18
2556147-4	1989	TRH-stimulated inositol phosphate production was also significantly inhibited by interleukin 1 beta.	Inositol Phosphates	15-33	interleukin 1 beta	Homo sapiens	81-99
2556147-6	1989	This latter effect may suggest that the reduced lactotropes sensitivity to TRH action may be partially due to interleukin 1 beta inhibition of phosphatidylinositol breakdown.	Phosphatidylinositols	143-163	interleukin 1 beta	Homo sapiens	110-128
2553812-5	1989	However, induction of the macrophage phenotype by pretreatment of ML-3 cells with the phorbol ester, PMA, followed by HCMV challenge, resulted in a greatly extended period of expression of IL-1 beta, TNF-alpha, MAD-9, and CSF-1 but not MAD-6 and MAD-2.	Phorbol Esters	86-99	interleukin 1 beta	Homo sapiens	189-198
2687062-6	1989	Interleukin-1 beta exposure increased the oxidation of D-[U-14C]glucose at 5.5 mmol/l glucose by 25% and at 16.7 mmol/l glucose by 60%.	d-[u-14c]glucose	55-71	interleukin 1 beta	Homo sapiens	0-18
2817905-6	1989	Taken together with the results of steady-state measurements, we suggest that the single tryptophan of IL-1 beta is statically quenched by neighboring charged residues, whereas the tryptophan fluorescence of IL-1 alpha is unaffected by ionic strength, and that the tryptophans of the two proteins have different accessibilities to ionic quenchers.	Tryptophan	89-99	interleukin 1 beta	Homo sapiens	103-112
2817905-6	1989	Taken together with the results of steady-state measurements, we suggest that the single tryptophan of IL-1 beta is statically quenched by neighboring charged residues, whereas the tryptophan fluorescence of IL-1 alpha is unaffected by ionic strength, and that the tryptophans of the two proteins have different accessibilities to ionic quenchers.	Tryptophan	265-276	interleukin 1 beta	Homo sapiens	103-112
2687062-6	1989	Interleukin-1 beta exposure increased the oxidation of D-[U-14C]glucose at 5.5 mmol/l glucose by 25% and at 16.7 mmol/l glucose by 60%.	Glucose	64-71	interleukin 1 beta	Homo sapiens	0-18
2687062-6	1989	Interleukin-1 beta exposure increased the oxidation of D-[U-14C]glucose at 5.5 mmol/l glucose by 25% and at 16.7 mmol/l glucose by 60%.	Glucose	86-93	interleukin 1 beta	Homo sapiens	0-18
2509610-11	1989	PBMC cultured with LPS and latex beads in the absence of serum released 30-40K Mr IL-1 alpha, as well as 17K Mr IL-1 alpha and 17K Mr IL-1 beta.	lps	19-22	interleukin 1 beta	Homo sapiens	134-143
2792008-2	1989	Mean blood calcium levels fell significantly in both groups of animals 3 h after the first IL-1 injections and returned to pretreatment values at 5 h. However, at 24 and 48 h mean values were significantly higher than those in saline-heated controls.	Calcium	11-18	interleukin 1 beta	Homo sapiens	91-95
2803314-5	1989	Actinomycin D inhibited IL-1 effects on PLA2 mRNA levels.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	24-28
2809260-0	1989	Increased endotoxin and interleukin-1 beta concentrations in cerebrospinal fluid of infants with coliform meningitis and ventriculitis associated with intraventricular gentamicin therapy.	Gentamicins	168-178	interleukin 1 beta	Homo sapiens	24-42
2809260-3	1989	Mean interleukin-1 beta concentrations in ventricular cerebrospinal fluid correlated significantly with adverse outcome and with mean concentrations of endotoxin, white blood cells, and protein and inversely with glucose concentrations.	Glucose	213-220	interleukin 1 beta	Homo sapiens	5-23
2809260-4	1989	Mean and peak endotoxin and interleukin-1 beta concentrations were significantly higher in infants who received intraventricular gentamicin and intravenous antibiotics than in infants given intravenous antibiotics alone.	Gentamicins	129-139	interleukin 1 beta	Homo sapiens	28-46
2809260-5	1989	Intraventricular gentamicin may have caused release of endotoxin from gram-negative bacilli in ventricular cerebrospinal fluid, resulting in increased interleukin-1 beta concentrations and inflammation, which could have contributed to the poor outcome in these patients.	Gentamicins	17-27	interleukin 1 beta	Homo sapiens	151-169
2808341-0	1989	Biotinylation of reactive amino groups in native recombinant human interleukin-1 beta.	reactive amino	17-31	interleukin 1 beta	Homo sapiens	67-85
2808341-1	1989	Recombinant human interleukin-1 beta (rIL-1 beta) was chemically modified by a 10-fold molar excess (reagent:protein) of sulfosuccinimidyl 6-(biotinamido) hexanoate (sulfo-NHS-LC-biotin) or sulfosuccinimidobiotin (sulfo-NHS-biotin) under mild conditions.	sulfosuccinimidyl 6-(biotinamido)hexanoate	121-164	interleukin 1 beta	Homo sapiens	18-36
2808341-1	1989	Recombinant human interleukin-1 beta (rIL-1 beta) was chemically modified by a 10-fold molar excess (reagent:protein) of sulfosuccinimidyl 6-(biotinamido) hexanoate (sulfo-NHS-LC-biotin) or sulfosuccinimidobiotin (sulfo-NHS-biotin) under mild conditions.	sulfosuccinimidyl 6-(biotinamido)hexanoate	166-185	interleukin 1 beta	Homo sapiens	18-36
2808341-1	1989	Recombinant human interleukin-1 beta (rIL-1 beta) was chemically modified by a 10-fold molar excess (reagent:protein) of sulfosuccinimidyl 6-(biotinamido) hexanoate (sulfo-NHS-LC-biotin) or sulfosuccinimidobiotin (sulfo-NHS-biotin) under mild conditions.	biotinyl-N-hydroxysulfosuccinimide ester	190-212	interleukin 1 beta	Homo sapiens	18-36
2808341-1	1989	Recombinant human interleukin-1 beta (rIL-1 beta) was chemically modified by a 10-fold molar excess (reagent:protein) of sulfosuccinimidyl 6-(biotinamido) hexanoate (sulfo-NHS-LC-biotin) or sulfosuccinimidobiotin (sulfo-NHS-biotin) under mild conditions.	sulfo-N-hydroxysuccinimide-biotin	214-230	interleukin 1 beta	Homo sapiens	18-36
2803314-6	1989	Coordinate effects of IL-1 on RAC PLA2 activity were observed with respect to time and dose dependence as well as actinomycin D sensitivity.	Dactinomycin	114-127	interleukin 1 beta	Homo sapiens	22-26
2674299-5	1989	Using polyclonal antibodies and the avidin-biotin peroxidase complex, we demonstrated the presence of both IL-1 alpha and IL-1 beta in normal and psoriatic formalin-fixed paraffin-embedded tissues.	Formaldehyde	156-164	interleukin 1 beta	Homo sapiens	122-131
2553025-3	1989	When stimulated by appropriate concentrations of recombinant interleukin-1 beta (rIL-1 beta), ASC proliferate and produce PGE.	Prostaglandins E	122-125	interleukin 1 beta	Homo sapiens	61-79
2697686-0	1989	Decreased cell replication and polyamine content in insulin-producing cells after exposure to human interleukin 1 beta.	Polyamines	31-40	interleukin 1 beta	Homo sapiens	100-118
2674299-5	1989	Using polyclonal antibodies and the avidin-biotin peroxidase complex, we demonstrated the presence of both IL-1 alpha and IL-1 beta in normal and psoriatic formalin-fixed paraffin-embedded tissues.	Paraffin	171-179	interleukin 1 beta	Homo sapiens	122-131
2476485-3	1989	The ability to release histamine has also been claimed for IL-1 but we cannot confirm this.	Histamine	23-32	interleukin 1 beta	Homo sapiens	59-63
2789325-6	1989	PBMNC spontaneously produced low levels of IL-1 beta and IL-6 that were augmented by the addition of hr IL-1 alpha.	pbmnc	0-5	interleukin 1 beta	Homo sapiens	43-52
2787682-6	1989	Interleukin-1 beta (IL-1 beta) transcripts were induced by EGF, TNF, or LPS and were inhibited by hydrocortisone (HC).	Hydrocortisone	98-112	interleukin 1 beta	Homo sapiens	0-18
2506272-0	1989	Prostaglandin E2 production is synergistically increased in cultured human glomerular mesangial cells by combinations of IL-1 and tumor necrosis factor-alpha 1.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	121-159
2506272-1	1989	Both IL-1 alpha and IL-1 beta and TNF-alpha induced a time- and dose-dependent release of authentic PGE2 from cultured human glomerular mesangial cells (HMC).	Dinoprostone	100-104	interleukin 1 beta	Homo sapiens	20-29
2506272-3	1989	Combinations of IL-1 and TNF-alpha when added simultaneously to HMC resulted in a dose-dependent synergistic increase in PGE2 production.	Dinoprostone	121-125	interleukin 1 beta	Homo sapiens	16-20
2506272-5	1989	Arachidonic acid (AA) release experiments and measurement of cyclooxygenase activity, revealed that while both were increased by IL-1 beta and TNF-alpha alone (IL-1 beta greater than TNF-alpha), combinations of IL-1 beta and TNF-alpha resulted in only additive increases in AA release and cyclooxygenase activity.	Arachidonic Acid	0-16	interleukin 1 beta	Homo sapiens	129-138
2528582-8	1989	In addition, the inhibitor blocked IL-1-stimulated collagenase production from rabbit articular chondrocytes and IL-1-induced PGE2 production from human fibroblasts and synovial cells.	Dinoprostone	126-130	interleukin 1 beta	Homo sapiens	35-39
2528582-8	1989	In addition, the inhibitor blocked IL-1-stimulated collagenase production from rabbit articular chondrocytes and IL-1-induced PGE2 production from human fibroblasts and synovial cells.	Dinoprostone	126-130	interleukin 1 beta	Homo sapiens	113-117
2528582-9	1989	The IL-1 inhibitor was not transforming growth factor beta (TGF beta) as determined by: the failure of anti-TGF beta antibodies to reduce IL-1 inhibitory activity, the separation of TGF beta from the IL-1 inhibitor by ion exchange chromatography, and the failure of TGF beta to inhibit IL-1-induced PGE2 production from synovial cells.	Dinoprostone	299-303	interleukin 1 beta	Homo sapiens	4-8
2787682-6	1989	Interleukin-1 beta (IL-1 beta) transcripts were induced by EGF, TNF, or LPS and were inhibited by hydrocortisone (HC).	Hydrocortisone	98-112	interleukin 1 beta	Homo sapiens	20-29
2668162-1	1989	Recombinant human interleukin-1 alpha (rhIL-1 alpha) and recombinant human interleukin 1 beta (rhIL-1 beta) stimulated the time- and concentration-dependent release of glycosaminoglycan (GAG) from bovine nasal cartilage explants.	Glycosaminoglycans	168-185	interleukin 1 beta	Homo sapiens	75-93
2665849-8	1989	In one case of AML showing significant 3H-TdR uptake in the absence of CSFs, this spontaneous DNA synthesis was found to depend on autocrine IL-1 beta release as it could be suppressed with anti-IL-1 beta antibody or anti-GM-CSF.	Tritium	39-41	interleukin 1 beta	Homo sapiens	141-150
2665849-8	1989	In one case of AML showing significant 3H-TdR uptake in the absence of CSFs, this spontaneous DNA synthesis was found to depend on autocrine IL-1 beta release as it could be suppressed with anti-IL-1 beta antibody or anti-GM-CSF.	Tritium	39-41	interleukin 1 beta	Homo sapiens	195-204
2507640-1	1989	This study examined the secretion of IL-1 alpha and IL-1 beta by THP-1 leukemia cells following activation with mezerein and promotion of synthesis by interferon (IFN-gamma).	mezerein	112-120	interleukin 1 beta	Homo sapiens	52-61
2789072-1	1989	Cultured human synovial fibroblasts were stimulated with human recombinant interleukin 1 beta to overproduce prostaglandin E (PGE) and hyaluronic acid (HA).	Prostaglandins E	109-124	interleukin 1 beta	Homo sapiens	75-93
2789072-1	1989	Cultured human synovial fibroblasts were stimulated with human recombinant interleukin 1 beta to overproduce prostaglandin E (PGE) and hyaluronic acid (HA).	Prostaglandins E	126-129	interleukin 1 beta	Homo sapiens	75-93
2789072-1	1989	Cultured human synovial fibroblasts were stimulated with human recombinant interleukin 1 beta to overproduce prostaglandin E (PGE) and hyaluronic acid (HA).	Hyaluronic Acid	135-150	interleukin 1 beta	Homo sapiens	75-93
2789072-1	1989	Cultured human synovial fibroblasts were stimulated with human recombinant interleukin 1 beta to overproduce prostaglandin E (PGE) and hyaluronic acid (HA).	Hyaluronic Acid	152-154	interleukin 1 beta	Homo sapiens	75-93
2668162-1	1989	Recombinant human interleukin-1 alpha (rhIL-1 alpha) and recombinant human interleukin 1 beta (rhIL-1 beta) stimulated the time- and concentration-dependent release of glycosaminoglycan (GAG) from bovine nasal cartilage explants.	Glycosaminoglycans	187-190	interleukin 1 beta	Homo sapiens	75-93
2787354-5	1989	Purified human rIL-1 alpha and IL-1 beta increased the levels of both products in the supernatants of the synovial cells; TNF-alpha raised the PGE2 levels but raised the plasminogen activator activity only weakly and inconsistently.	Dinoprostone	143-147	interleukin 1 beta	Homo sapiens	31-40
2787856-5	1989	In CSF2 the mean IL-1 beta concentration was 135 +/- 343 pg/ml, and IL-1 beta concentrations correlated significantly with CSF2 leukocyte count, with glucose, lactate, protein, and tumor necrosis factor concentrations, and with neurologic sequelae.	Glucose	150-157	interleukin 1 beta	Homo sapiens	68-77
2503605-1	1989	The induction of prostaglandin (PG) biosynthesis by human recombinant interleukin-1 beta (hrIL-1 beta) has been investigated using rat-isolated stomach strip preparations.	Prostaglandins	17-30	interleukin 1 beta	Homo sapiens	70-88
2503605-1	1989	The induction of prostaglandin (PG) biosynthesis by human recombinant interleukin-1 beta (hrIL-1 beta) has been investigated using rat-isolated stomach strip preparations.	Prostaglandins	32-34	interleukin 1 beta	Homo sapiens	70-88
2787856-5	1989	In CSF2 the mean IL-1 beta concentration was 135 +/- 343 pg/ml, and IL-1 beta concentrations correlated significantly with CSF2 leukocyte count, with glucose, lactate, protein, and tumor necrosis factor concentrations, and with neurologic sequelae.	Lactic Acid	159-166	interleukin 1 beta	Homo sapiens	68-77
2787856-9	1989	Our data suggest a possible role of IL-1 beta and tumor necrosis factor as mediators of meningeal inflammation in patients with bacterial meningitis, and might explain, in part, the beneficial effect of dexamethasone as adjunctive treatment in this disease.	Dexamethasone	203-216	interleukin 1 beta	Homo sapiens	36-45
2472445-0	1989	Preincubation of human synovial cells with IL-1 modulates prostaglandin E2 release in response to bradykinin.	Dinoprostone	58-74	interleukin 1 beta	Homo sapiens	43-47
2503867-4	1989	Northern blotting analysis demonstrated, however, that LPS and lipid A are equally effective in inducing the accumulation of IL-1 alpha and IL-1 beta mRNA.	Lipid A	63-70	interleukin 1 beta	Homo sapiens	140-149
2507329-3	1989	When the cells were pretreated with IL-1 alpha or IL-1 beta for 24 h, their ability to release PGE2 in response to a short incubation (1 h) with bradykinin, TNF alpha or a second dose of IL-1 was potentiated.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	50-59
2507329-3	1989	When the cells were pretreated with IL-1 alpha or IL-1 beta for 24 h, their ability to release PGE2 in response to a short incubation (1 h) with bradykinin, TNF alpha or a second dose of IL-1 was potentiated.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	36-40
2507329-7	1989	It seems likely, therefore, that activation of phospholipase A2 which occurs during a short incubation with IL-1, TNF alpha or bradykinin releases substrate, AA, which is more rapidly converted to PGE2 by cells in which CO has been induced.	Dinoprostone	197-201	interleukin 1 beta	Homo sapiens	108-112
2472445-4	1989	However, after a period of preincubation with the cytokine, IL-1, which is itself a stimulus for PGE2 production, synovial cells exhibited a further striking time- and dose-dependent response to bradykinin.	Dinoprostone	97-101	interleukin 1 beta	Homo sapiens	60-64
2472445-5	1989	Maximal release of PGE2 was observed in response to 10(-7) to 10(-6) M bradykinin after first pretreating the cells for 24 h with 5 to 10 U/ml of IL-1.	Dinoprostone	19-23	interleukin 1 beta	Homo sapiens	146-150
2472445-7	1989	The bradykinin analog, lysylbradykinin, was equipotent in inducing PGE2 release from IL-1 pretreated synovial cells, whereas des(Arg9) bradykinin, substance P, and neurokinins A and B were ineffective in this regard in both IL-1-pretreated and in resting cells.	Dinoprostone	67-71	interleukin 1 beta	Homo sapiens	85-89
2472445-9	1989	The synergistic response in PGE2 production induced by IL-1 and bradykinin was significantly inhibited by pretreatment with 1 microM indomethacin or dexamethasone (96 and 94% inhibition, respectively).	Dinoprostone	28-32	interleukin 1 beta	Homo sapiens	55-59
2472445-9	1989	The synergistic response in PGE2 production induced by IL-1 and bradykinin was significantly inhibited by pretreatment with 1 microM indomethacin or dexamethasone (96 and 94% inhibition, respectively).	Indomethacin	133-145	interleukin 1 beta	Homo sapiens	55-59
2472445-9	1989	The synergistic response in PGE2 production induced by IL-1 and bradykinin was significantly inhibited by pretreatment with 1 microM indomethacin or dexamethasone (96 and 94% inhibition, respectively).	Dexamethasone	149-162	interleukin 1 beta	Homo sapiens	55-59
2789003-4	1989	It was confirmed that two types of H-RS cells, HDLM-1 and KM-H2, can secrete IL-1, especially after treatment with phorbol ester.	Phorbol Esters	115-128	interleukin 1 beta	Homo sapiens	77-81
2788477-0	1989	Interleukin-1 beta inhibits acetylcholine synthesis in the pituitary corticotropic cell line AtT20.	Acetylcholine	28-41	interleukin 1 beta	Homo sapiens	0-18
2788477-2	1989	Treatment of the cells with picomolar concentrations of human interleukin-1 beta inhibited [3H]acetylcholine production.	Acetylcholine	91-108	interleukin 1 beta	Homo sapiens	62-80
2503616-1	1989	The effect of recombinant human interleukin-1 beta (IL-1 beta) on the follicle stimulating hormone-(FSH) induced secretion of estradiol was investigated using cultured granulosa cells obtained from immature rats with diethylstilbestrol implants.	Estradiol	126-135	interleukin 1 beta	Homo sapiens	32-50
2471731-2	1989	Preincubation of monocytes in 100 U/ml IFN-gamma or in 0.25 microgram/ml cycloheximide (Cx) leads to a partial maintenance of the ability to produce IL-1 in response to subsequent stimulation with LPS, whereas preincubation in both reagents leads to a near complete maintenance of this response.	Cycloheximide	73-86	interleukin 1 beta	Homo sapiens	149-153
2471731-2	1989	Preincubation of monocytes in 100 U/ml IFN-gamma or in 0.25 microgram/ml cycloheximide (Cx) leads to a partial maintenance of the ability to produce IL-1 in response to subsequent stimulation with LPS, whereas preincubation in both reagents leads to a near complete maintenance of this response.	Cycloheximide	88-90	interleukin 1 beta	Homo sapiens	149-153
2471731-9	1989	Cx preincubation led to increases in both the peak and duration of transcription as well as to enhanced secretion of IL-1 beta protein.	Cycloheximide	0-2	interleukin 1 beta	Homo sapiens	117-126
2503616-1	1989	The effect of recombinant human interleukin-1 beta (IL-1 beta) on the follicle stimulating hormone-(FSH) induced secretion of estradiol was investigated using cultured granulosa cells obtained from immature rats with diethylstilbestrol implants.	Estradiol	126-135	interleukin 1 beta	Homo sapiens	52-61
2503616-2	1989	Estradiol secretion was significantly reduced by IL-1 beta in cultures containing FSH and either 10(-7) or 10(-8) M androstenedione as a substrate for estradiol synthesis.	Androstenedione	116-131	interleukin 1 beta	Homo sapiens	49-58
2503616-2	1989	Estradiol secretion was significantly reduced by IL-1 beta in cultures containing FSH and either 10(-7) or 10(-8) M androstenedione as a substrate for estradiol synthesis.	Estradiol	151-160	interleukin 1 beta	Homo sapiens	49-58
2503616-5	1989	The reduction of FSH-stimulated estradiol secretion by IL-1 beta was greatest after a 48 h culture in the presence of 10(-8) M androstenedione.	Androstenedione	127-142	interleukin 1 beta	Homo sapiens	55-64
2503616-7	1989	Finally, IL-1 beta also suppressed the forskolin-induced secretion of estradiol.	Colforsin	39-48	interleukin 1 beta	Homo sapiens	9-18
2503616-7	1989	Finally, IL-1 beta also suppressed the forskolin-induced secretion of estradiol.	Estradiol	70-79	interleukin 1 beta	Homo sapiens	9-18
2786594-4	1989	Human recombinant IL-1 beta, human natural IL-1, and partially purified murine IL-1-rich supernatant also stimulated eicosanoid production by macrophages, although IL-1 alpha appeared to be the most effective.	Eicosanoids	117-127	interleukin 1 beta	Homo sapiens	18-27
2503616-8	1989	These results suggest that IL-1 beta may play some role in the multifactorial regulation of aromatase and estrogen secretion in the early developing follicle, and IL-1 beta may exert an effect on the cAMP-adenylate cyclase messenger system in granulosa cells.	Cyclic AMP	200-204	interleukin 1 beta	Homo sapiens	163-172
2786594-4	1989	Human recombinant IL-1 beta, human natural IL-1, and partially purified murine IL-1-rich supernatant also stimulated eicosanoid production by macrophages, although IL-1 alpha appeared to be the most effective.	Eicosanoids	117-127	interleukin 1 beta	Homo sapiens	18-22
2787508-7	1989	The cleavage product of this protease is identical to authentic IL-1 beta as shown by mobility on SDS/PAGE and amino acid sequence analysis of the [3H]leucine-labeled product.	Sodium Dodecyl Sulfate	98-101	interleukin 1 beta	Homo sapiens	64-73
2787508-7	1989	The cleavage product of this protease is identical to authentic IL-1 beta as shown by mobility on SDS/PAGE and amino acid sequence analysis of the [3H]leucine-labeled product.	Tritium	148-150	interleukin 1 beta	Homo sapiens	64-73
2787508-7	1989	The cleavage product of this protease is identical to authentic IL-1 beta as shown by mobility on SDS/PAGE and amino acid sequence analysis of the [3H]leucine-labeled product.	Leucine	151-158	interleukin 1 beta	Homo sapiens	64-73
2786880-10	1989	Immunocytochemistry of extracellular matrix components revealed a decrease in staining intensity of chondroitin and dermatan sulfate in the 3-week matrix following IL-1 beta incubation.	Chondroitin	100-111	interleukin 1 beta	Homo sapiens	164-173
2785913-1	1989	Recombinant human interleukin-1 beta (IL-1 beta) significantly increased prostaglandin E2 (PGE2) in a dose-dependent manner in rat astrocyte culture.	Dinoprostone	73-89	interleukin 1 beta	Homo sapiens	18-36
2785913-1	1989	Recombinant human interleukin-1 beta (IL-1 beta) significantly increased prostaglandin E2 (PGE2) in a dose-dependent manner in rat astrocyte culture.	Dinoprostone	73-89	interleukin 1 beta	Homo sapiens	38-47
2785913-1	1989	Recombinant human interleukin-1 beta (IL-1 beta) significantly increased prostaglandin E2 (PGE2) in a dose-dependent manner in rat astrocyte culture.	Dinoprostone	91-95	interleukin 1 beta	Homo sapiens	18-36
2785913-1	1989	Recombinant human interleukin-1 beta (IL-1 beta) significantly increased prostaglandin E2 (PGE2) in a dose-dependent manner in rat astrocyte culture.	Dinoprostone	91-95	interleukin 1 beta	Homo sapiens	38-47
2500449-5	1989	Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38).	Tetradecanoylphorbol Acetate	85-121	interleukin 1 beta	Homo sapiens	171-180
2500449-5	1989	Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38).	Tetradecanoylphorbol Acetate	123-126	interleukin 1 beta	Homo sapiens	171-180
2500449-5	1989	Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38).	teleocidins	132-142	interleukin 1 beta	Homo sapiens	171-180
2500449-7	1989	Accumulation of IL-1 beta mRNA was also increased by a calcium ionophore (A23187) and an inhibitor of the Na+/K+ pump (ouabain); both compounds are known to increase cytoplasmic levels of Ca++.	Calcium	55-62	interleukin 1 beta	Homo sapiens	16-25
2500449-7	1989	Accumulation of IL-1 beta mRNA was also increased by a calcium ionophore (A23187) and an inhibitor of the Na+/K+ pump (ouabain); both compounds are known to increase cytoplasmic levels of Ca++.	Calcimycin	74-80	interleukin 1 beta	Homo sapiens	16-25
2500449-8	1989	Stability of IL-1 beta mRNA in fibroblasts exposed to TPA was more than fourfold greater than after fibroblasts were exposed to either TNF alpha or cycloheximide.	Tetradecanoylphorbol Acetate	54-57	interleukin 1 beta	Homo sapiens	13-22
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	57-88	interleukin 1 beta	Homo sapiens	155-164
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	90-93	interleukin 1 beta	Homo sapiens	155-164
2500449-8	1989	Stability of IL-1 beta mRNA in fibroblasts exposed to TPA was more than fourfold greater than after fibroblasts were exposed to either TNF alpha or cycloheximide.	Cycloheximide	148-161	interleukin 1 beta	Homo sapiens	13-22
2786880-10	1989	Immunocytochemistry of extracellular matrix components revealed a decrease in staining intensity of chondroitin and dermatan sulfate in the 3-week matrix following IL-1 beta incubation.	Dermatan Sulfate	116-132	interleukin 1 beta	Homo sapiens	164-173
2497185-0	1989	IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis.	Epoprostenol	55-59	interleukin 1 beta	Homo sapiens	0-4
2656735-5	1989	Recombinant IL-1 beta (rIL-1 beta) also stimulated [3H]thymidine incorporation into thyrocytes from normal subjects and patients with Graves" disease, and it increased the proportion of thyrocytes in the S phase of the cell cycle.	Tritium	52-54	interleukin 1 beta	Homo sapiens	12-21
2656735-5	1989	Recombinant IL-1 beta (rIL-1 beta) also stimulated [3H]thymidine incorporation into thyrocytes from normal subjects and patients with Graves" disease, and it increased the proportion of thyrocytes in the S phase of the cell cycle.	Thymidine	55-64	interleukin 1 beta	Homo sapiens	12-21
2497185-8	1989	IL-1 beta enhancement of thrombin-stimulated PGI2 production was concentration and time dependent and required protein synthesis.	Epoprostenol	45-49	interleukin 1 beta	Homo sapiens	0-9
2497185-9	1989	IL-1 beta pretreatment also enhanced PGI2 production in response to another agonist, histamine, and to exogenously added substrates, arachidonic acid or PGH2.	Epoprostenol	37-41	interleukin 1 beta	Homo sapiens	0-9
2497185-9	1989	IL-1 beta pretreatment also enhanced PGI2 production in response to another agonist, histamine, and to exogenously added substrates, arachidonic acid or PGH2.	Histamine	85-94	interleukin 1 beta	Homo sapiens	0-9
2497185-9	1989	IL-1 beta pretreatment also enhanced PGI2 production in response to another agonist, histamine, and to exogenously added substrates, arachidonic acid or PGH2.	Arachidonic Acid	133-149	interleukin 1 beta	Homo sapiens	0-9
2785566-4	1989	Preincubation of PBM with IL-4 did, however, inhibit LPS-induced IL-1 and TNF production in a dose- and time-related fashion.	phytobacteriomycin	17-20	interleukin 1 beta	Homo sapiens	65-77
2541203-13	1989	LPS-induced secretion of TNF-alpha and IL-1 beta was completely blocked by hydrocortisone, but the priming effect of LPS on O2- release was only partly blocked.	Hydrocortisone	75-89	interleukin 1 beta	Homo sapiens	39-48
2497185-2	1989	A 24-h pretreatment with IL-1 beta doubled the low level of constitutive PGI2 production.	Epoprostenol	73-77	interleukin 1 beta	Homo sapiens	25-34
2497185-9	1989	IL-1 beta pretreatment also enhanced PGI2 production in response to another agonist, histamine, and to exogenously added substrates, arachidonic acid or PGH2.	Prostaglandin H2	153-157	interleukin 1 beta	Homo sapiens	0-9
2497185-10	1989	Our results indicate that activation by IL-1 and related cytokines selectively primes endothelial cells for enhanced PGI2 production, but not vWF secretion or PAF synthesis, in response to thrombin and histamine.	Epoprostenol	117-121	interleukin 1 beta	Homo sapiens	40-44
2497185-4	1989	The most striking increase in PGI2 production was observed in IL-1 beta-treated HUVEC that were subsequently stimulated with thrombin.	Epoprostenol	30-34	interleukin 1 beta	Homo sapiens	62-71
2497185-10	1989	Our results indicate that activation by IL-1 and related cytokines selectively primes endothelial cells for enhanced PGI2 production, but not vWF secretion or PAF synthesis, in response to thrombin and histamine.	Histamine	202-211	interleukin 1 beta	Homo sapiens	40-44
2469713-7	1989	IL-3, GM-CSF, and IL-1 can also release histamine at lower concentrations (less than 5 ng/ml) when incubated with basophils in the presence of D2O.	Histamine	40-49	interleukin 1 beta	Homo sapiens	18-22
2785989-4	1989	Here we show, by nuclear run-on and transient gene expression analyses, that IL-1 beta induction is a promoter function and that dexamethasone suppresses IL-1 beta-induced gene activity.	Dexamethasone	129-142	interleukin 1 beta	Homo sapiens	154-163
2540256-1	1989	Both purified human monocyte interleukin-1 and recombinant interleukin-1 (beta) primed neutrophils for increased superoxide production and chemiluminescence in response to f-met-leu-phe.	Superoxides	113-123	interleukin 1 beta	Homo sapiens	59-79
2540256-1	1989	Both purified human monocyte interleukin-1 and recombinant interleukin-1 (beta) primed neutrophils for increased superoxide production and chemiluminescence in response to f-met-leu-phe.	leucyl-phenylalanine	178-185	interleukin 1 beta	Homo sapiens	59-79
2544986-2	1989	The effect of gamma interferon (IFN-gamma) on interleukin 1 (IL-1) production by human monocytes induced either by bacterial lipopolysaccharide (LPS) or silica dust was examined.	Silicon Dioxide	153-159	interleukin 1 beta	Homo sapiens	46-65
2544986-7	1989	In contrast to these data, IFN-gamma had a decreasing effect on IL-1 release by monocytes stimulated with silica dust; in monocyte cultures stimulated with a sub-optimal dose of silica (100 micrograms/ml), only minute amounts of biologically active IL-1 were released in the presence of IFN-gamma.	Silicon Dioxide	106-112	interleukin 1 beta	Homo sapiens	64-68
2544986-7	1989	In contrast to these data, IFN-gamma had a decreasing effect on IL-1 release by monocytes stimulated with silica dust; in monocyte cultures stimulated with a sub-optimal dose of silica (100 micrograms/ml), only minute amounts of biologically active IL-1 were released in the presence of IFN-gamma.	Silicon Dioxide	178-184	interleukin 1 beta	Homo sapiens	249-253
2544986-11	1989	In contrast, in silica-stimulated monocytes IFN-gamma reduced the steady-state levels of IL-1 beta mRNA.	Silicon Dioxide	16-22	interleukin 1 beta	Homo sapiens	89-98
2651523-3	1989	Nanogram amounts (0.1 to 10 ng/ml) of synthetic monodephospho partial structures of E. coli lipid A were necessary for IL-1 induction.	Lipid A	92-99	interleukin 1 beta	Homo sapiens	119-123
2651523-4	1989	Synthetic pentaacyl partial structures induced IL-1 very weakly.	pentaacyl	10-19	interleukin 1 beta	Homo sapiens	47-51
2651523-6	1989	Compared to LPS million-fold higher doses of natural and synthetic 3-deoxy-D-manno-octulosonic acid containing core oligosaccharides were necessary for IL-1 induction.	2-keto-3-deoxyoctonate	67-99	interleukin 1 beta	Homo sapiens	152-156
2651523-6	1989	Compared to LPS million-fold higher doses of natural and synthetic 3-deoxy-D-manno-octulosonic acid containing core oligosaccharides were necessary for IL-1 induction.	Oligosaccharides	116-132	interleukin 1 beta	Homo sapiens	152-156
2651523-7	1989	Dose-response investigations with LPS and natural or synthetic partial structures established the following hierarchy in IL-1 induction-capacity: LPS greater than lipid A much greater than lipid A partial structures greater than core oligosaccharides greater than oligoacyl lipid A.	Lipid A	163-170	interleukin 1 beta	Homo sapiens	121-125
2651523-7	1989	Dose-response investigations with LPS and natural or synthetic partial structures established the following hierarchy in IL-1 induction-capacity: LPS greater than lipid A much greater than lipid A partial structures greater than core oligosaccharides greater than oligoacyl lipid A.	Oligosaccharides	234-250	interleukin 1 beta	Homo sapiens	121-125
2651523-7	1989	Dose-response investigations with LPS and natural or synthetic partial structures established the following hierarchy in IL-1 induction-capacity: LPS greater than lipid A much greater than lipid A partial structures greater than core oligosaccharides greater than oligoacyl lipid A.	oligoacyl lipid a	264-281	interleukin 1 beta	Homo sapiens	121-125
2651523-8	1989	Lipid A was shown here to be the portion of LPS mainly responsible for induction of IL-1 activity.	Lipid A	0-7	interleukin 1 beta	Homo sapiens	84-88
2651523-11	1989	In co-incubation experiments, precursor Ia of lipid A produced dose-dependent inhibition of production and release of IL-1 activity induced by lipid A or LPS, but not by Staphylococcus epidermidis or PHA.	Lipid A	46-53	interleukin 1 beta	Homo sapiens	118-122
2651523-11	1989	In co-incubation experiments, precursor Ia of lipid A produced dose-dependent inhibition of production and release of IL-1 activity induced by lipid A or LPS, but not by Staphylococcus epidermidis or PHA.	Lipid A	143-150	interleukin 1 beta	Homo sapiens	118-122
2651523-13	1989	We conclude that lipid A is the main portion of LPS responsible for induction of IL-1, and that specific activation- and/or binding-mechanisms are involved in stimulation of cells with LPS and/or lipid A.	Lipid A	17-24	interleukin 1 beta	Homo sapiens	81-85
2469713-7	1989	IL-3, GM-CSF, and IL-1 can also release histamine at lower concentrations (less than 5 ng/ml) when incubated with basophils in the presence of D2O.	Deuterium Oxide	143-146	interleukin 1 beta	Homo sapiens	18-22
2787167-0	1989	Activation of distinct protein kinase C isozymes by phorbol esters: correlation with induction of interleukin 1 beta gene expression.	Phorbol Esters	52-66	interleukin 1 beta	Homo sapiens	98-116
2484299-7	1989	Using an ELISA, specific for IL-1 beta, there was clear cut evidence for increased production of this cytokine by FLE cells in response to human recombinant gamma-interferon (IFN-gamma), Staphylococcus aureus, and lipopolysaccharide (LPS) in combination with silica (LPS/silica).	Silicon Dioxide	259-265	interleukin 1 beta	Homo sapiens	29-38
2484299-7	1989	Using an ELISA, specific for IL-1 beta, there was clear cut evidence for increased production of this cytokine by FLE cells in response to human recombinant gamma-interferon (IFN-gamma), Staphylococcus aureus, and lipopolysaccharide (LPS) in combination with silica (LPS/silica).	Silicon Dioxide	271-277	interleukin 1 beta	Homo sapiens	29-38
2787167-6	1989	Higher concentrations of TPA, which partially or totally depleted protein kinase C levels in the cells (10(-9)-2 X 10(-5) M), had an inhibitory effect on IL-1 beta mRNA expression.	Tetradecanoylphorbol Acetate	25-28	interleukin 1 beta	Homo sapiens	154-163
2787167-4	1989	Addition of TPA to serum-starved U937 cells induced the expression of the interleukin 1 beta (IL-1 beta) gene.	Tetradecanoylphorbol Acetate	12-15	interleukin 1 beta	Homo sapiens	74-92
2787167-4	1989	Addition of TPA to serum-starved U937 cells induced the expression of the interleukin 1 beta (IL-1 beta) gene.	Tetradecanoylphorbol Acetate	12-15	interleukin 1 beta	Homo sapiens	94-103
2466831-2	1989	Treatment of normal human plasma with methylamine resulted in the discovery of an interleukin-1 beta(IL-1 beta) binding protein.	methylamine	38-49	interleukin 1 beta	Homo sapiens	82-100
2466831-2	1989	Treatment of normal human plasma with methylamine resulted in the discovery of an interleukin-1 beta(IL-1 beta) binding protein.	methylamine	38-49	interleukin 1 beta	Homo sapiens	101-110
2541588-7	1989	Interleukin-1 beta also inhibited forskolin- and dibutyryl cAMP-stimulated testosterone production.	Colforsin	34-43	interleukin 1 beta	Homo sapiens	0-18
2466831-4	1989	The protein-IL-1 beta complex had a Mr of approximately 400,000 in non-reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis but became dissociated when exposed to beta-mercaptoethanol.	Sodium Dodecyl Sulfate	80-102	interleukin 1 beta	Homo sapiens	12-21
2541588-7	1989	Interleukin-1 beta also inhibited forskolin- and dibutyryl cAMP-stimulated testosterone production.	Bucladesine	49-63	interleukin 1 beta	Homo sapiens	0-18
2541588-7	1989	Interleukin-1 beta also inhibited forskolin- and dibutyryl cAMP-stimulated testosterone production.	Testosterone	75-87	interleukin 1 beta	Homo sapiens	0-18
2466831-4	1989	The protein-IL-1 beta complex had a Mr of approximately 400,000 in non-reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis but became dissociated when exposed to beta-mercaptoethanol.	polyacrylamide	103-117	interleukin 1 beta	Homo sapiens	12-21
2541588-9	1989	Moreover, the conversion of exogenously added androgen precursors (progesterone and 17 alpha-hydroxyprogesterone) to testosterone by human chorionic gonadotropin-stimulated cells was suppressed by interleukin-1 beta suggesting that the activity of the 17 alpha-hydroxylase enzyme may be decreased.	Progesterone	67-79	interleukin 1 beta	Homo sapiens	197-215
2466831-4	1989	The protein-IL-1 beta complex had a Mr of approximately 400,000 in non-reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis but became dissociated when exposed to beta-mercaptoethanol.	Mercaptoethanol	177-197	interleukin 1 beta	Homo sapiens	12-21
2541588-9	1989	Moreover, the conversion of exogenously added androgen precursors (progesterone and 17 alpha-hydroxyprogesterone) to testosterone by human chorionic gonadotropin-stimulated cells was suppressed by interleukin-1 beta suggesting that the activity of the 17 alpha-hydroxylase enzyme may be decreased.	17-alpha-Hydroxyprogesterone	84-112	interleukin 1 beta	Homo sapiens	197-215
2466831-11	1989	In contrast, the yield of "F" alpha 2M IL-1 beta complex formation was increased severalfold in the presence of 2.5 mM Zn2+.	Zinc	119-123	interleukin 1 beta	Homo sapiens	39-48
2541588-9	1989	Moreover, the conversion of exogenously added androgen precursors (progesterone and 17 alpha-hydroxyprogesterone) to testosterone by human chorionic gonadotropin-stimulated cells was suppressed by interleukin-1 beta suggesting that the activity of the 17 alpha-hydroxylase enzyme may be decreased.	Testosterone	117-129	interleukin 1 beta	Homo sapiens	197-215
2466831-12	1989	These findings indicate that "F" alpha 2M interacts with IL-1 beta through a thiol-disulfide exchange reaction.	Sulfhydryl Compounds	77-82	interleukin 1 beta	Homo sapiens	57-66
2466831-12	1989	These findings indicate that "F" alpha 2M interacts with IL-1 beta through a thiol-disulfide exchange reaction.	Disulfides	83-92	interleukin 1 beta	Homo sapiens	57-66
2784471-4	1989	PBM, upon stimulation by lipopolysaccharide (LPS), expressed approximately ten-fold more IL-1 beta mRNA than IL-1 alpha.	pbm	0-3	interleukin 1 beta	Homo sapiens	89-98
2539414-7	1989	The addition of IL1 beta (2.5 and 10.0 U/ml) to serum-driven fibroblast cultures resulted in greater proliferation, which was inhibitable by the presence of pentoxifylline and A81-3138 as anti-fibrotic agents in certain disorders of fibrosis.	Pentoxifylline	157-171	interleukin 1 beta	Homo sapiens	16-24
2522658-3	1989	Endogenous labeling studies demonstrated that acute myeloid leukemia cells produced either only the 33-kDa propeptide or both the propeptide and the 17-kDa mature form of IL-1 beta.	17-kda	149-155	interleukin 1 beta	Homo sapiens	171-180
2522658-6	1989	After acid treatment of the cells, a surface receptor for IL-1 could be demonstrated, which mediated 125I-labeled IL-1-specific uptake by leukemic cells.	Iodine-125	101-105	interleukin 1 beta	Homo sapiens	58-62
2522658-6	1989	After acid treatment of the cells, a surface receptor for IL-1 could be demonstrated, which mediated 125I-labeled IL-1-specific uptake by leukemic cells.	Iodine-125	101-105	interleukin 1 beta	Homo sapiens	114-118
2465167-4	1989	Similar to IL-1, the double-stranded RNA polyriboinosinic-polyribocytidilic acid (poly[rI].poly[rC]) also stimulated release of CSA by endothelial cells in a dose-dependent manner.	Cyclosporine	128-131	interleukin 1 beta	Homo sapiens	11-15
2465167-5	1989	The kinetics of IL-1-induced CSA release as opposed to poly(rI).poly(rC)-induced release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Cyclosporine	29-32	interleukin 1 beta	Homo sapiens	16-20
2465167-5	1989	The kinetics of IL-1-induced CSA release as opposed to poly(rI).poly(rC)-induced release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Poly C	64-72	interleukin 1 beta	Homo sapiens	16-20
2465167-5	1989	The kinetics of IL-1-induced CSA release as opposed to poly(rI).poly(rC)-induced release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Polyinosinic acid	125-133	interleukin 1 beta	Homo sapiens	16-20
2465167-5	1989	The kinetics of IL-1-induced CSA release as opposed to poly(rI).poly(rC)-induced release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Poly C	134-142	interleukin 1 beta	Homo sapiens	16-20
2465167-5	1989	The kinetics of IL-1-induced CSA release as opposed to poly(rI).poly(rC)-induced release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Cyclosporine	151-154	interleukin 1 beta	Homo sapiens	16-20
2465167-6	1989	An anti-IL-1 beta antiserum was able to completely neutralize the IL-1-induced CSA release, but had no effect on poly(rI).poly(rC)-dependent CSA production, indicating that the latter effect was mediated by other mechanisms than intermediate production of IL-1 beta.	Cyclosporine	79-82	interleukin 1 beta	Homo sapiens	8-17
2465167-6	1989	An anti-IL-1 beta antiserum was able to completely neutralize the IL-1-induced CSA release, but had no effect on poly(rI).poly(rC)-dependent CSA production, indicating that the latter effect was mediated by other mechanisms than intermediate production of IL-1 beta.	Cyclosporine	79-82	interleukin 1 beta	Homo sapiens	8-12
2465167-7	1989	Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found.	Poly C	61-69	interleukin 1 beta	Homo sapiens	35-39
2495301-5	1989	IFN-gamma (1,000 U/ml) reduced [3H]thymidine (TdR) incorporation into DNA by SMC stimulated with the well-defined mitogens IL 1 (from 15.3 +/- 0.7 to 6.2 +/- 0.7 dpm X 10(-3)/24 h) or platelet-derived growth factor (PDGF) (from 18.5 +/- 1.0 to 7.3 +/- 0.7 dpm X 10(-3)/24 h).	3h]thymidine	32-44	interleukin 1 beta	Homo sapiens	123-127
2785834-2	1989	Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2).	Dinoprostone	184-200	interleukin 1 beta	Homo sapiens	126-144
2785834-2	1989	Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2).	Dinoprostone	202-206	interleukin 1 beta	Homo sapiens	126-144
2496956-3	1989	We used the phorbol ester/lipopolysaccharide (PMA + LPS) co-induction of IL-1 mRNA and CD13 expression in U937 cells to demonstrate the specificity of the technique.	Phorbol Esters	12-25	interleukin 1 beta	Homo sapiens	73-77
2496956-3	1989	We used the phorbol ester/lipopolysaccharide (PMA + LPS) co-induction of IL-1 mRNA and CD13 expression in U937 cells to demonstrate the specificity of the technique.	Tetradecanoylphorbol Acetate	46-49	interleukin 1 beta	Homo sapiens	73-77
2521822-10	1989	The DNA content in IL-1-exposed islets cultured at 11.1 mM glucose was decreased by about 20% but not in islets cultured at other glucose concentrations.	Glucose	59-66	interleukin 1 beta	Homo sapiens	19-23
2521822-10	1989	The DNA content in IL-1-exposed islets cultured at 11.1 mM glucose was decreased by about 20% but not in islets cultured at other glucose concentrations.	Glucose	130-137	interleukin 1 beta	Homo sapiens	19-23
2784676-2	1989	IL-1 beta stimulated cellular proliferation and the synthesis of prostaglandin E2 and plasminogen activator activity by the cultured human osteoblast-like cells.	Dinoprostone	65-81	interleukin 1 beta	Homo sapiens	0-9
2788802-1	1989	The human brain library carried in the EMBL3 vector was employed for isolating prointerleukin 1 beta genomic sequences using three synthetic 20-member oligonucleotides.	Oligonucleotides	151-167	interleukin 1 beta	Homo sapiens	79-100
2493373-0	1989	Preparation, characterization and application of interleukin-1 beta mutant proteins with surface-accessible cysteine residues.	Cysteine	108-116	interleukin 1 beta	Homo sapiens	49-67
2493373-1	1989	Two mutants of interleukin-1 beta (K27C and K138C) were produced using site-specific mutagenesis in which lysine residues at positions 27 and 138 of the mature protein sequence were substituted by cysteine residues.	Lysine	106-112	interleukin 1 beta	Homo sapiens	15-33
2493373-1	1989	Two mutants of interleukin-1 beta (K27C and K138C) were produced using site-specific mutagenesis in which lysine residues at positions 27 and 138 of the mature protein sequence were substituted by cysteine residues.	Cysteine	197-205	interleukin 1 beta	Homo sapiens	15-33
2783391-9	1989	Serological evidence as well as isoelectric point determination further supported that the predominant form of IL-1 synthesized was of the pI 5 type, and immunoprecipitation of 35S-labeled cell lysate with monospecific polyclonal antibody to IL-1 alpha or IL-1 beta detected only IL-1 alpha precursor.	Sulfur-35	177-180	interleukin 1 beta	Homo sapiens	256-265
2646141-0	1989	Inhibition of interleukin-1 beta release from cultured human peripheral blood mononuclear cells by prednisolone.	Prednisolone	99-111	interleukin 1 beta	Homo sapiens	14-32
2646141-1	1989	Prednisolone, a water-soluble glucocorticoid hormone, suppressed the secretion of interleukin-1 beta from human peripheral blood mononuclear cells in culture.	Prednisolone	0-12	interleukin 1 beta	Homo sapiens	82-100
2646141-1	1989	Prednisolone, a water-soluble glucocorticoid hormone, suppressed the secretion of interleukin-1 beta from human peripheral blood mononuclear cells in culture.	Water	16-21	interleukin 1 beta	Homo sapiens	82-100
2784408-4	1989	In addition, IL-1 beta and TNF alpha were potent inducers of PGE2 production while exogenous PGE2 was growth inhibiting.	Dinoprostone	61-65	interleukin 1 beta	Homo sapiens	13-22
2784408-6	1989	Further examination of IL-1 beta- and TNF alpha-induced PGE2 secretion revealed IL-1 beta to be a more potent stimulator; however, this observation may be due, in part, to differences in the kinetics of induction.	Dinoprostone	56-60	interleukin 1 beta	Homo sapiens	23-32
2784408-6	1989	Further examination of IL-1 beta- and TNF alpha-induced PGE2 secretion revealed IL-1 beta to be a more potent stimulator; however, this observation may be due, in part, to differences in the kinetics of induction.	Dinoprostone	56-60	interleukin 1 beta	Homo sapiens	80-89
2784408-7	1989	Rabbit anti-IL-1 beta and anti-TNF alpha specifically neutralized both proliferation and PGE2 production induced by these monokines, but anti-IL-1 beta (or anti-IL-1 alpha) did not block TNF alpha activity.	Dinoprostone	89-93	interleukin 1 beta	Homo sapiens	12-21
2783532-2	1989	Microinjection (icv) of human recombinant IL-1 beta (50 ng) caused acute (response within 60 min) increases in colonic temperature (1.8 degrees C), oxygen consumption (Vo2; 36%), white blood cell count (96%), and brown adipose tissue (BAT) activity (mitochondrial GDP binding, 129%) in conscious rats.	Oxygen	148-154	interleukin 1 beta	Homo sapiens	42-51
2783590-1	1989	Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163-171.	Hyaluronic Acid	13-28	interleukin 1 beta	Homo sapiens	95-113
2783590-7	1989	The synthetic human IL-1 beta peptide 163-171 (Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys), which has been previously shown to stimulate thymocyte proliferation but not fibroblast PGE2 production, is also able to stimulate fibroblast HA production.	Valine	47-50	interleukin 1 beta	Homo sapiens	20-29
2783590-7	1989	The synthetic human IL-1 beta peptide 163-171 (Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys), which has been previously shown to stimulate thymocyte proliferation but not fibroblast PGE2 production, is also able to stimulate fibroblast HA production.	Glutamine	51-54	interleukin 1 beta	Homo sapiens	20-29
2784909-0	1989	Incubation of T cell or monocytic cell lines with 1,25-dihydroxyvitamin D3 before mitogen stimulation potentiates IL-2 and IL-1 beta mRNA levels.	Calcitriol	50-74	interleukin 1 beta	Homo sapiens	123-132
2521831-2	1989	Equilibrium binding analysis using both 125I-labeled IL-1 alpha and IL-1 beta showed that RAJI cells have a higher number of binding sites/cell for IL-1 beta (2400, Kd 2.2 nM) than for IL-1 alpha (316, Kd 0.13 nM).	Iodine-125	40-44	interleukin 1 beta	Homo sapiens	148-157
2521831-4	1989	Dexamethasone (DXM) induced on RAJI cells a time-dependent increase in binding sites for both IL-1 beta and IL-1 alpha without affecting their binding affinities.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	94-103
2521831-4	1989	Dexamethasone (DXM) induced on RAJI cells a time-dependent increase in binding sites for both IL-1 beta and IL-1 alpha without affecting their binding affinities.	Dexamethasone	15-18	interleukin 1 beta	Homo sapiens	94-103
2784033-5	1989	The decreased amount of IL-1 in HS macrophage supernatants appeared to be due to a defect in release of IL-1 from the cells and not due to a defect in production of the mediator, since total IL-1 (IL-1 present in the cell lysates plus that in the cell supernatants) was similar in the NS and HS groups.	hassio	32-34	interleukin 1 beta	Homo sapiens	24-28
2784033-5	1989	The decreased amount of IL-1 in HS macrophage supernatants appeared to be due to a defect in release of IL-1 from the cells and not due to a defect in production of the mediator, since total IL-1 (IL-1 present in the cell lysates plus that in the cell supernatants) was similar in the NS and HS groups.	hassio	32-34	interleukin 1 beta	Homo sapiens	104-108
2784033-5	1989	The decreased amount of IL-1 in HS macrophage supernatants appeared to be due to a defect in release of IL-1 from the cells and not due to a defect in production of the mediator, since total IL-1 (IL-1 present in the cell lysates plus that in the cell supernatants) was similar in the NS and HS groups.	hassio	32-34	interleukin 1 beta	Homo sapiens	104-108
2784033-5	1989	The decreased amount of IL-1 in HS macrophage supernatants appeared to be due to a defect in release of IL-1 from the cells and not due to a defect in production of the mediator, since total IL-1 (IL-1 present in the cell lysates plus that in the cell supernatants) was similar in the NS and HS groups.	hassio	32-34	interleukin 1 beta	Homo sapiens	104-108
2784033-6	1989	In addition, after 24 h in culture, LPS-stimulated HS macrophages released significantly less prostaglandin E2 (PGE2) (which can suppress IL-1 production) than did NS macrophages; in the presence of indomethacin, which abolished macrophage PGE2 release, no augmentation of LPS-stimulated IL-1 release was observed.	Dinoprostone	94-110	interleukin 1 beta	Homo sapiens	138-142
2784033-6	1989	In addition, after 24 h in culture, LPS-stimulated HS macrophages released significantly less prostaglandin E2 (PGE2) (which can suppress IL-1 production) than did NS macrophages; in the presence of indomethacin, which abolished macrophage PGE2 release, no augmentation of LPS-stimulated IL-1 release was observed.	Dinoprostone	112-116	interleukin 1 beta	Homo sapiens	138-142
2784033-6	1989	In addition, after 24 h in culture, LPS-stimulated HS macrophages released significantly less prostaglandin E2 (PGE2) (which can suppress IL-1 production) than did NS macrophages; in the presence of indomethacin, which abolished macrophage PGE2 release, no augmentation of LPS-stimulated IL-1 release was observed.	Indomethacin	199-211	interleukin 1 beta	Homo sapiens	288-292
2646146-3	1989	Dexamethasone inhibited the induction of these cytokine mRNAs by IL-1.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	65-69
2786697-5	1989	Glucocorticoids strongly inhibit and PGE2 slightly inhibits IL-1-induced IL-6 mRNA expression in synoviocytes.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	60-64
2783532-2	1989	Microinjection (icv) of human recombinant IL-1 beta (50 ng) caused acute (response within 60 min) increases in colonic temperature (1.8 degrees C), oxygen consumption (Vo2; 36%), white blood cell count (96%), and brown adipose tissue (BAT) activity (mitochondrial GDP binding, 129%) in conscious rats.	vo2	168-171	interleukin 1 beta	Homo sapiens	42-51
2783532-2	1989	Microinjection (icv) of human recombinant IL-1 beta (50 ng) caused acute (response within 60 min) increases in colonic temperature (1.8 degrees C), oxygen consumption (Vo2; 36%), white blood cell count (96%), and brown adipose tissue (BAT) activity (mitochondrial GDP binding, 129%) in conscious rats.	Guanosine Diphosphate	264-267	interleukin 1 beta	Homo sapiens	42-51
2695356-7	1989	During systemic retinoids therapy the amount of both IL-1 species decreased in lesional and nonlesional psoriatic skin.	Retinoids	16-25	interleukin 1 beta	Homo sapiens	53-57
2493987-4	1989	FK-565 also acted synergistically with rIFN-gamma to stimulate monocytes to produce membrane-associated IL-1 activity, which induced C3H/HeJ thymocyte blastogenesis in response to phytohemagglutinin P. The tumoricidal and thymocyte-stimulating activities of the fixed monocytes were almost completely inhibited by a specific anti-(IL-1 alpha) antiserum, but not by a specific anti-(IL-1 beta) antiserum or monoclonal anti-TNF antibody.	heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine	0-6	interleukin 1 beta	Homo sapiens	382-391
2787228-5	1989	Killing of the cartilage cells abolished induced GAG release by all forms of IL-1.	Glycosaminoglycans	49-52	interleukin 1 beta	Homo sapiens	77-81
2787228-7	1989	Both forms of recombinant IL-1 inhibited GAG synthesis when continually present in the culture medium.	Glycosaminoglycans	41-44	interleukin 1 beta	Homo sapiens	26-30
2787228-8	1989	Actinomycin D and cycloheximide inhibited IL-1 dependent cartilage destruction whereas indomethacin did not.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	42-46
2787228-8	1989	Actinomycin D and cycloheximide inhibited IL-1 dependent cartilage destruction whereas indomethacin did not.	Cycloheximide	18-31	interleukin 1 beta	Homo sapiens	42-46
2546788-2	1989	An intraperitoneal injection of recombinant human IL-1 beta (160 U/rat) significantly elevated serum levels of ACTH and corticosterone (CS).	Corticosterone	120-134	interleukin 1 beta	Homo sapiens	50-59
2513175-10	1989	Above 5 microM, the non-steroidal anti-inflammatory compounds indomethacin and BW755C increased IL-1 beta biosynthesis.	Indomethacin	62-74	interleukin 1 beta	Homo sapiens	96-105
2513175-10	1989	Above 5 microM, the non-steroidal anti-inflammatory compounds indomethacin and BW755C increased IL-1 beta biosynthesis.	4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine	79-85	interleukin 1 beta	Homo sapiens	96-105
2513175-11	1989	Nordihydroguaiaretic acid inhibited the level of the secreted form of IL-1 beta, but tended to increase the cell-associated level.	Masoprocol	0-25	interleukin 1 beta	Homo sapiens	70-79
2546788-2	1989	An intraperitoneal injection of recombinant human IL-1 beta (160 U/rat) significantly elevated serum levels of ACTH and corticosterone (CS).	Corticosterone	136-138	interleukin 1 beta	Homo sapiens	50-59
3265268-6	1988	The PGE2 levels were measured in the perfusate and were found to be enhanced more than 10-fold after the infusion of IL-1 alpha or IL-1 beta.	Dinoprostone	4-8	interleukin 1 beta	Homo sapiens	131-140
2621325-0	1989	Potent inhibition of interleukin 1 beta-mediated human melanoma (A375.6) lysis by corticosteroids, staurosporine, and tilorone.	Staurosporine	99-112	interleukin 1 beta	Homo sapiens	21-39
2621325-0	1989	Potent inhibition of interleukin 1 beta-mediated human melanoma (A375.6) lysis by corticosteroids, staurosporine, and tilorone.	Tilorone	118-126	interleukin 1 beta	Homo sapiens	21-39
2621325-7	1989	In contrast, corticosteroids (dexamethasone, hydrocortisone, and paramethasone acetate), tilorone, and protein kinase C inhibitors (1-[5-isoquinolinyl-sulfonyl]-2-methylpiperazine and staurosporine) significantly inhibited IL-1 beta-mediated A375.6 cytolysis.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	132-179	interleukin 1 beta	Homo sapiens	223-232
2783319-5	1989	Both human rTNF-alpha and beta (0.1 to 100 ng/ml) induced transient accumulation of IL-1 mRNA by adult human vascular SMC that peaked between 1 and 4 h. The inhibitor of RNA synthesis actinomycin D (1 microgram/ml) blocked the induction of IL-1 mRNA, whereas inhibition of protein synthesis with cycloheximide (1 microgram/ml) resulted in a marked "superinduction" of both IL-1 alpha and IL-1 beta mRNA species.	Dactinomycin	184-197	interleukin 1 beta	Homo sapiens	84-88
2783323-8	1989	These Ba and Bb preparations at 10 and 50 micrograms/ml, respectively, induced IL-1 production in the presence of 5 micrograms/ml polymyxin B (PMB).	Barium	6-8	interleukin 1 beta	Homo sapiens	79-83
2783323-8	1989	These Ba and Bb preparations at 10 and 50 micrograms/ml, respectively, induced IL-1 production in the presence of 5 micrograms/ml polymyxin B (PMB).	boeravinone B	13-15	interleukin 1 beta	Homo sapiens	79-83
2783323-9	1989	However, Ba and Bb preparations purified by affinity chromatography and HPLC contained lower levels of endotoxin contamination and displayed IL-1-inducing activities at Ba and Bb concentrations of 50 and 100 micrograms/ml, respectively, that were almost completely inhibited by PMB.	Barium	9-11	interleukin 1 beta	Homo sapiens	141-145
2783323-9	1989	However, Ba and Bb preparations purified by affinity chromatography and HPLC contained lower levels of endotoxin contamination and displayed IL-1-inducing activities at Ba and Bb concentrations of 50 and 100 micrograms/ml, respectively, that were almost completely inhibited by PMB.	boeravinone B	16-18	interleukin 1 beta	Homo sapiens	141-145
2662172-4	1989	The IL-1 beta purification was completed by gel permeation chromatography on Sephadex G-50.	sephadex	77-90	interleukin 1 beta	Homo sapiens	4-13
3264290-5	1988	This stimulatory effect of IL-1 was observed only when IL-1-stimulated PGE2 synthesis was blocked by the cyclooxygenase inhibitor indomethacin.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	27-31
3264195-1	1988	Serial observations of blast cell colony development from spleen cells of mice treated with 5-fluorouracil (5-FU) four days earlier revealed that either form of human interleukin-1 (IL-1 alpha or IL-1 beta) hastens the emergence of interleukin-3 (IL-3)-dependent blast cell colonies.	Fluorouracil	92-106	interleukin 1 beta	Homo sapiens	196-205
3143761-6	1988	SDS-PAGE analysis after radioimmunoprecipitation with anti-IL-1 antibodies indicates that cell-associated IL-1 resulting from IL-2 stimulation was in the form of the 35 kDa IL-1 precursor whereas secreted IL-1 was almost entirely in the form of the mature 18 kDa product.	Sodium Dodecyl Sulfate	0-3	interleukin 1 beta	Homo sapiens	59-63
3143761-6	1988	SDS-PAGE analysis after radioimmunoprecipitation with anti-IL-1 antibodies indicates that cell-associated IL-1 resulting from IL-2 stimulation was in the form of the 35 kDa IL-1 precursor whereas secreted IL-1 was almost entirely in the form of the mature 18 kDa product.	Sodium Dodecyl Sulfate	0-3	interleukin 1 beta	Homo sapiens	106-110
3143761-6	1988	SDS-PAGE analysis after radioimmunoprecipitation with anti-IL-1 antibodies indicates that cell-associated IL-1 resulting from IL-2 stimulation was in the form of the 35 kDa IL-1 precursor whereas secreted IL-1 was almost entirely in the form of the mature 18 kDa product.	Sodium Dodecyl Sulfate	0-3	interleukin 1 beta	Homo sapiens	106-110
3143761-6	1988	SDS-PAGE analysis after radioimmunoprecipitation with anti-IL-1 antibodies indicates that cell-associated IL-1 resulting from IL-2 stimulation was in the form of the 35 kDa IL-1 precursor whereas secreted IL-1 was almost entirely in the form of the mature 18 kDa product.	Sodium Dodecyl Sulfate	0-3	interleukin 1 beta	Homo sapiens	106-110
3264290-5	1988	This stimulatory effect of IL-1 was observed only when IL-1-stimulated PGE2 synthesis was blocked by the cyclooxygenase inhibitor indomethacin.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	55-59
3264290-5	1988	This stimulatory effect of IL-1 was observed only when IL-1-stimulated PGE2 synthesis was blocked by the cyclooxygenase inhibitor indomethacin.	Indomethacin	130-142	interleukin 1 beta	Homo sapiens	27-31
3264290-5	1988	This stimulatory effect of IL-1 was observed only when IL-1-stimulated PGE2 synthesis was blocked by the cyclooxygenase inhibitor indomethacin.	Indomethacin	130-142	interleukin 1 beta	Homo sapiens	55-59
2847761-2	1988	Tritiated arachidonic acid (3H-AA)-labeled rat synovial fibroblasts stimulated with human recombinant interleukin-1 beta (rIL-1 beta) released incorporated radiolabel in a time-dependent and dose-dependent manner, with labeled prostaglandins representing 29% of the released radiolabel.	3h-aa	28-33	interleukin 1 beta	Homo sapiens	102-120
3263855-3	1988	Blockage of the prostaglandin synthesis by indomethacin reduced the basal level of IL-1 beta mRNA in control cultures and decreased also the stimulatory effect exerted by both IL-1s on IL-1 beta gene expression.	Prostaglandins	16-29	interleukin 1 beta	Homo sapiens	83-92
3263855-3	1988	Blockage of the prostaglandin synthesis by indomethacin reduced the basal level of IL-1 beta mRNA in control cultures and decreased also the stimulatory effect exerted by both IL-1s on IL-1 beta gene expression.	Prostaglandins	16-29	interleukin 1 beta	Homo sapiens	185-194
3263855-3	1988	Blockage of the prostaglandin synthesis by indomethacin reduced the basal level of IL-1 beta mRNA in control cultures and decreased also the stimulatory effect exerted by both IL-1s on IL-1 beta gene expression.	Indomethacin	43-55	interleukin 1 beta	Homo sapiens	83-92
3263855-3	1988	Blockage of the prostaglandin synthesis by indomethacin reduced the basal level of IL-1 beta mRNA in control cultures and decreased also the stimulatory effect exerted by both IL-1s on IL-1 beta gene expression.	Indomethacin	43-55	interleukin 1 beta	Homo sapiens	185-194
3263855-4	1988	These data suggest that IL-1 and prostaglandin (mainly PGE2) may act synergistically to stimulate IL-1 gene expression in dermal fibroblasts, contributing as a local amplifier system to the alterations of connective tissue in inflammatory processes.	Prostaglandins	33-46	interleukin 1 beta	Homo sapiens	98-102
3263855-4	1988	These data suggest that IL-1 and prostaglandin (mainly PGE2) may act synergistically to stimulate IL-1 gene expression in dermal fibroblasts, contributing as a local amplifier system to the alterations of connective tissue in inflammatory processes.	Dinoprostone	55-59	interleukin 1 beta	Homo sapiens	24-28
3263855-4	1988	These data suggest that IL-1 and prostaglandin (mainly PGE2) may act synergistically to stimulate IL-1 gene expression in dermal fibroblasts, contributing as a local amplifier system to the alterations of connective tissue in inflammatory processes.	Dinoprostone	55-59	interleukin 1 beta	Homo sapiens	98-102
2847761-2	1988	Tritiated arachidonic acid (3H-AA)-labeled rat synovial fibroblasts stimulated with human recombinant interleukin-1 beta (rIL-1 beta) released incorporated radiolabel in a time-dependent and dose-dependent manner, with labeled prostaglandins representing 29% of the released radiolabel.	Prostaglandins	227-241	interleukin 1 beta	Homo sapiens	102-120
3137260-6	1988	(90,000), which co-migrated with purified plasma factor B. Incubation of U-937 cells with the immunostimulants PMA, LPS, IFN-gamma, and IL-1 resulted in a dose-dependent augmentation of factor B production.	Tetradecanoylphorbol Acetate	111-114	interleukin 1 beta	Homo sapiens	136-140
3266214-0	1988	Site-specific mutagenesis of the human interleukin-1 beta gene: the role of arginine residue at the N-terminal region.	Arginine	76-84	interleukin 1 beta	Homo sapiens	39-57
3266214-3	1988	When we changed the arginine at the 4th position (Arg4) in IL-1 beta to other specific amino acids, there was a marked difference in the relative extent of biological and receptor binding activities among the mutants.	Arginine	20-28	interleukin 1 beta	Homo sapiens	59-68
3266214-5	1988	Our results demonstrate that the arginine residue at the 4th position in IL-1 beta is important, but not essential, for IL-1 beta to exhibit its biological and receptor binding activities, and the positive charge at this site plays a key role for IL-1 beta to exert the activities.	Arginine	33-41	interleukin 1 beta	Homo sapiens	73-82
3263853-1	1988	The acute monocytic leukemia cell line THP-1 secretes predominantly IL-1 beta after treatment with bacterial lipopolysaccharide and tumour promoting phorbol ester (PMA).	Tetradecanoylphorbol Acetate	164-167	interleukin 1 beta	Homo sapiens	68-77
3140820-0	1988	Stimulation of the hyaluronic acid levels of human synovial fibroblasts by recombinant human tumor necrosis factor alpha, tumor necrosis factor beta (lymphotoxin), interleukin-1 alpha, and interleukin-1 beta.	Hyaluronic Acid	19-34	interleukin 1 beta	Homo sapiens	189-207
3140820-4	1988	We report here that recombinant human tumor necrosis factor alpha, tumor necrosis factor beta (lymphotoxin), interleukin-1 alpha, and interleukin-1 beta stimulate the hyaluronic acid (HA) levels of human synovial fibroblast-like cells.	Hyaluronic Acid	167-182	interleukin 1 beta	Homo sapiens	134-152
3140820-4	1988	We report here that recombinant human tumor necrosis factor alpha, tumor necrosis factor beta (lymphotoxin), interleukin-1 alpha, and interleukin-1 beta stimulate the hyaluronic acid (HA) levels of human synovial fibroblast-like cells.	Hyaluronic Acid	184-186	interleukin 1 beta	Homo sapiens	134-152
2970890-3	1988	Specific binding of 125I-labeled recombinant IL-1 beta by MDA-MB-415 and SW-48 reached a maximum by 2 h of incubation, and an equivalent amount was bound by each cell type.	Iodine-125	20-24	interleukin 1 beta	Homo sapiens	45-54
2460095-2	1988	In the present study we investigated the effect of the interleukin 1 beta on intracellular free calcium concentrations in 235-1 cell line both in basal conditions and after stimulation by the calcium channel activator maitotoxin.	Calcium	96-103	interleukin 1 beta	Homo sapiens	55-73
2460095-4	1988	The preincubation of these cells with interleukin 1 beta for 48h modulates maitotoxin stimulation of calcium fluxes without modifying basal intracellular free calcium levels.	Calcium	101-108	interleukin 1 beta	Homo sapiens	38-56
2460095-4	1988	The preincubation of these cells with interleukin 1 beta for 48h modulates maitotoxin stimulation of calcium fluxes without modifying basal intracellular free calcium levels.	Calcium	159-166	interleukin 1 beta	Homo sapiens	38-56
2460095-5	1988	Low concentrations of interleukin 1 beta (0.01 pM, 1 pM) caused a marked reduction of intracellular free calcium concentrations increase induced by maitotoxin while higher doses of the monokine potentiated maitotoxin stimulation of calcium fluxes.	Calcium	105-112	interleukin 1 beta	Homo sapiens	22-40
2460095-5	1988	Low concentrations of interleukin 1 beta (0.01 pM, 1 pM) caused a marked reduction of intracellular free calcium concentrations increase induced by maitotoxin while higher doses of the monokine potentiated maitotoxin stimulation of calcium fluxes.	Calcium	232-239	interleukin 1 beta	Homo sapiens	22-40
2460095-6	1988	The specificity of interleukin 1 beta effect was tested by means of polyclonal anti-interleukin 1 beta antibody (titer 1:100) which significantly abolished the inhibitory effect of interleukin 1 beta on free cytosolic calcium levels.	Calcium	218-225	interleukin 1 beta	Homo sapiens	19-37
2460095-6	1988	The specificity of interleukin 1 beta effect was tested by means of polyclonal anti-interleukin 1 beta antibody (titer 1:100) which significantly abolished the inhibitory effect of interleukin 1 beta on free cytosolic calcium levels.	Calcium	218-225	interleukin 1 beta	Homo sapiens	84-102
2460095-6	1988	The specificity of interleukin 1 beta effect was tested by means of polyclonal anti-interleukin 1 beta antibody (titer 1:100) which significantly abolished the inhibitory effect of interleukin 1 beta on free cytosolic calcium levels.	Calcium	218-225	interleukin 1 beta	Homo sapiens	84-102
3262503-0	1988	Human recombinant interleukin-1 beta decreases plasma thyroid hormone and thyroid stimulating hormone levels in rats.	Thyrotropin	74-101	interleukin 1 beta	Homo sapiens	18-36
3148711-3	1988	SF from active RA contained a significant amount of IL-1 beta and IL-2 but not gamma-IFN.	Radium	15-17	interleukin 1 beta	Homo sapiens	52-61
3056398-1	1988	The effect of interleukin 1 (IL-1) and tumor necrosis factor (TNF) on the induction of prostacyclin (PGI2) synthesis in human vascular endothelial cells (EC) was investigated.	Epoprostenol	87-99	interleukin 1 beta	Homo sapiens	14-33
3052447-0	1988	The transcription of the interleukin 1 beta gene is induced with PMA and inhibited with dexamethasone in U937 cells.	Dexamethasone	88-101	interleukin 1 beta	Homo sapiens	25-43
3052447-1	1988	Interleukin 1 beta mRNA was induced with phorbol ester, not LPS, in the human histiocytic lymphoma cell line U937, but interleukin 1 alpha mRNA was not induced.	Phorbol Esters	41-54	interleukin 1 beta	Homo sapiens	0-18
3052447-2	1988	Nuclear run-on analysis showed that phorbol ester induced the transcription of interleukin 1 beta but did not induce it in the presence of cycloheximide.	Phorbol Esters	36-49	interleukin 1 beta	Homo sapiens	79-97
3052447-4	1988	Dexamethasone, an immunosuppressive and anti-inflammatory agent, decreased the level of interleukin 1 beta mRNA induced with phorbol ester.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	88-106
3052447-4	1988	Dexamethasone, an immunosuppressive and anti-inflammatory agent, decreased the level of interleukin 1 beta mRNA induced with phorbol ester.	Phorbol Esters	125-138	interleukin 1 beta	Homo sapiens	88-106
3052447-5	1988	The transcriptional analysis showed that dexamethasone inhibits the transcription of the interleukin 1 beta gene.	Dexamethasone	41-54	interleukin 1 beta	Homo sapiens	89-107
3139106-7	1988	Indomethacin increased the amount of cytokine produced in response to rGM-CSF for IL-1 beta and TNF but not for IL-1 alpha.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	82-91
3262792-1	1988	Changes in the concentration of cytosolic free calcium ((Ca2+)i) in response to purified blood monocyte IL-1 and human rIL-1 alpha and rIL-1 beta (17.5 kDa) were measured in murine L-M fibroblasts and in human foreskin fibroblasts using the fluorescent Ca2+ indicator, fura-2.	Calcium	47-54	interleukin 1 beta	Homo sapiens	104-108
3262792-7	1988	IL-1 alpha and IL-1 beta both induced a dose-related increase in prostaglandin E2, but only in the human fibroblasts.	Dinoprostone	65-81	interleukin 1 beta	Homo sapiens	15-24
3263120-3	1988	The dose-response curve of interleukin 1 beta effect on adenylate cyclase activity showed a significant inhibition of basal enzyme activity at 1 pM concentration, while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations.	Colforsin	187-196	interleukin 1 beta	Homo sapiens	27-45
3263120-7	1988	These data show that interleukin 1-beta interacts with the cAMP-generating system in the 235-1 clonal pituitary cells.	Cyclic AMP	59-63	interleukin 1 beta	Homo sapiens	21-39
3139749-4	1988	Chemical inducers of the heat-shock response (heavy metals, sulphydryl reagents) were also effective inhibitors of IL-1 beta biosynthesis.	sulphydryl reagents	60-79	interleukin 1 beta	Homo sapiens	115-124
3139749-6	1988	In addition, a gold salt currently used for therapy of chronic inflammation, auranofin, induced hsp and inhibited IL-1 beta biosynthesis, whereas a second salt, sodium aurothiomalate, did neither.	Salts	20-24	interleukin 1 beta	Homo sapiens	114-123
3139749-6	1988	In addition, a gold salt currently used for therapy of chronic inflammation, auranofin, induced hsp and inhibited IL-1 beta biosynthesis, whereas a second salt, sodium aurothiomalate, did neither.	Auranofin	77-86	interleukin 1 beta	Homo sapiens	114-123
3263144-3	1988	The results showed that ara-C exposure inhibits the proliferation of a higher proportion of clonogenic cells in cultures pretreated with growth factors than in the controls (mean inhibitory values: in the absence of growth factors = 49.8%; with IL-1 beta = 58.3%; with IL-3 78.9%).	Cytarabine	24-29	interleukin 1 beta	Homo sapiens	245-254
3137474-0	1988	Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue.	tripeptide K-26	67-77	interleukin 1 beta	Homo sapiens	0-18
2901097-1	1988	Human recombinant interleukin 1 alpha (IL-1 alpha) and IL-1 beta stimulated prostaglandin E2 synthesis in 3T3 fibroblasts in a time- and concentration-dependent manner.	Dinoprostone	76-92	interleukin 1 beta	Homo sapiens	55-64
2901097-2	1988	Enhanced prostaglandin E2 synthesis after IL-1 treatment was apparent by 1 hr and continued to increase for at least 2 days.	Dinoprostone	9-25	interleukin 1 beta	Homo sapiens	42-46
2901097-5	1988	In cells that had been pretreated with IL-1 for 24 hr, prostaglandin E2 synthesis in response to bradykinin was amplified more than 10-fold.	Dinoprostone	55-71	interleukin 1 beta	Homo sapiens	39-43
2901097-6	1988	IL-1 also amplified the receptor-mediated formation of prostaglandin E2 by bombesin and thrombin.	Dinoprostone	55-71	interleukin 1 beta	Homo sapiens	0-4
2901097-10	1988	Thus, IL-1 enhanced receptor-mediated release of prostaglandin E2 in response to bradykinin, bombesin, and thrombin by increasing the cellular levels of phospholipase A2, cyclooxygenase, and GTP-binding regulatory protein(s).	Dinoprostone	49-65	interleukin 1 beta	Homo sapiens	6-10
3137474-5	1988	We have delineated the region of IL-1 beta mediating the hyperalgesic effect and developed an analgesic tripeptide analogue of IL-1 beta which antagonizes hyperalgesia evoked by IL-1 beta and by the inflammatory agent carrageenan.	tripeptide K-26	104-114	interleukin 1 beta	Homo sapiens	33-42
3137474-5	1988	We have delineated the region of IL-1 beta mediating the hyperalgesic effect and developed an analgesic tripeptide analogue of IL-1 beta which antagonizes hyperalgesia evoked by IL-1 beta and by the inflammatory agent carrageenan.	tripeptide K-26	104-114	interleukin 1 beta	Homo sapiens	127-136
3137474-5	1988	We have delineated the region of IL-1 beta mediating the hyperalgesic effect and developed an analgesic tripeptide analogue of IL-1 beta which antagonizes hyperalgesia evoked by IL-1 beta and by the inflammatory agent carrageenan.	tripeptide K-26	104-114	interleukin 1 beta	Homo sapiens	127-136
3137474-5	1988	We have delineated the region of IL-1 beta mediating the hyperalgesic effect and developed an analgesic tripeptide analogue of IL-1 beta which antagonizes hyperalgesia evoked by IL-1 beta and by the inflammatory agent carrageenan.	Carrageenan	218-229	interleukin 1 beta	Homo sapiens	33-42
3137474-5	1988	We have delineated the region of IL-1 beta mediating the hyperalgesic effect and developed an analgesic tripeptide analogue of IL-1 beta which antagonizes hyperalgesia evoked by IL-1 beta and by the inflammatory agent carrageenan.	Carrageenan	218-229	interleukin 1 beta	Homo sapiens	127-136
3137474-5	1988	We have delineated the region of IL-1 beta mediating the hyperalgesic effect and developed an analgesic tripeptide analogue of IL-1 beta which antagonizes hyperalgesia evoked by IL-1 beta and by the inflammatory agent carrageenan.	Carrageenan	218-229	interleukin 1 beta	Homo sapiens	127-136
2900159-4	1988	Moreover, administration of SP and IL-1 beta to human PDL fibroblasts in vitro for 1 to 60 minutes resulted in significant increases in the levels of the intracellular "second messenger" cAMP, as well as of PGE2, a plasma membrane-associated fatty acid believed to serve as a local regulator of bone cell activity.	Cyclic AMP	187-191	interleukin 1 beta	Homo sapiens	35-44
3047139-2	1988	After selecting for transfected cells resistant to G418, two clones were found to constitutively express the IL-1 beta 31-kD precursor which was almost exclusively located in the cytosol.	antibiotic G 418	51-55	interleukin 1 beta	Homo sapiens	109-118
3261306-0	1988	Recombinant human interleukin-1 beta causes histamine release from human basophils.	Histamine	44-53	interleukin 1 beta	Homo sapiens	18-36
3261306-2	1988	Because of the similarity of our HRF to the physical chemical properties of interleukin-1 (IL-1) and tumor necrosis factor (TNF), we have assessed the ability of preparations of IL-1 and TNF to cause basophil histamine release (HR).	Histamine	209-218	interleukin 1 beta	Homo sapiens	178-190
3290009-5	1988	On day 0, IL-1 was found to totally inhibit glucose-stimulated insulin release, partially inhibit glucose oxidation, and induce a decrease in islet DNA content.	Glucose	44-51	interleukin 1 beta	Homo sapiens	10-14
2900159-4	1988	Moreover, administration of SP and IL-1 beta to human PDL fibroblasts in vitro for 1 to 60 minutes resulted in significant increases in the levels of the intracellular "second messenger" cAMP, as well as of PGE2, a plasma membrane-associated fatty acid believed to serve as a local regulator of bone cell activity.	Dinoprostone	207-211	interleukin 1 beta	Homo sapiens	35-44
3290009-5	1988	On day 0, IL-1 was found to totally inhibit glucose-stimulated insulin release, partially inhibit glucose oxidation, and induce a decrease in islet DNA content.	Glucose	98-105	interleukin 1 beta	Homo sapiens	10-14
2900159-4	1988	Moreover, administration of SP and IL-1 beta to human PDL fibroblasts in vitro for 1 to 60 minutes resulted in significant increases in the levels of the intracellular "second messenger" cAMP, as well as of PGE2, a plasma membrane-associated fatty acid believed to serve as a local regulator of bone cell activity.	Fatty Acids	242-252	interleukin 1 beta	Homo sapiens	35-44
3290009-7	1988	After 6 days in culture, the insulin-secretory response to glucose and the glucose oxidation rates of the IL-1-pretreated islets were completely restored, but there remained a reduced islet DNA content.	Glucose	75-82	interleukin 1 beta	Homo sapiens	106-110
3259597-5	1988	IL-1 beta was protected by the presence in the incubation medium of phosphoramidon, a specific inhibitor of endopeptidase 24.11.	phosphoramidon	68-82	interleukin 1 beta	Homo sapiens	0-9
3260603-6	1988	Immune precipitations of 35S-methionine-labeled cells indicate that the mesangial IL-1 is synthesized as a 33-kD precursor protein with a pI of 7.2.	Sulfur-35	25-28	interleukin 1 beta	Homo sapiens	82-86
3260603-6	1988	Immune precipitations of 35S-methionine-labeled cells indicate that the mesangial IL-1 is synthesized as a 33-kD precursor protein with a pI of 7.2.	Methionine	29-39	interleukin 1 beta	Homo sapiens	82-86
3259598-4	1988	Antibodies recognizing the regions 133-148 and 251-269 of human IL-1 beta could inhibit the activity of IL-1 beta, but not of IL-1 alpha, in two different biologic assays, the murine thymocyte proliferation and PGE2 release from human fibroblasts.	Dinoprostone	211-215	interleukin 1 beta	Homo sapiens	64-73
3259598-4	1988	Antibodies recognizing the regions 133-148 and 251-269 of human IL-1 beta could inhibit the activity of IL-1 beta, but not of IL-1 alpha, in two different biologic assays, the murine thymocyte proliferation and PGE2 release from human fibroblasts.	Dinoprostone	211-215	interleukin 1 beta	Homo sapiens	104-113
3259600-4	1988	IL-1 can also significantly increase survival and can "rescue" a number of animals if administered either before or after lethal doses of cyclophosphamide or gamma-irradiation.	Cyclophosphamide	138-154	interleukin 1 beta	Homo sapiens	0-4
2839894-6	1988	Moreover, the finding that after silica stimulation the amount of membrane-associated IL-1 (which was recently shown to be of the IL-1 alpha type) was low, while IL-1 alpha in the culture fluid was clearly elevated, suggests that the IL-1 alpha not attached to the cell membrane (or released from it) significantly contributes to the secreted IL-1 pool.	Silicon Dioxide	33-39	interleukin 1 beta	Homo sapiens	130-134
2839894-0	1988	Differential induction of membrane-associated interleukin 1 (IL-1) expression and IL-1 alpha and IL-1 beta secretion by lipopolysaccharide and silica in human monocytes.	Silicon Dioxide	143-149	interleukin 1 beta	Homo sapiens	97-106
3259230-8	1988	When protein synthesis was blocked by either cycloheximide, puromycin, or emetine, the induction of alpha 1-acid glycoprotein mRNA by recombinant human interleukin-1 beta was impaired suggesting the involvement of a short-lived protein in the induction of alpha 1-acid glycoprotein mRNA.	Cycloheximide	45-58	interleukin 1 beta	Homo sapiens	152-170
2839894-1	1988	Bacterial lipopolysaccharide (LPS) and silica dust are known to be effective inducers of interleukin 1 (IL-1) in human cultured monocytes.	Silicon Dioxide	39-45	interleukin 1 beta	Homo sapiens	89-108
3259230-8	1988	When protein synthesis was blocked by either cycloheximide, puromycin, or emetine, the induction of alpha 1-acid glycoprotein mRNA by recombinant human interleukin-1 beta was impaired suggesting the involvement of a short-lived protein in the induction of alpha 1-acid glycoprotein mRNA.	Puromycin	60-69	interleukin 1 beta	Homo sapiens	152-170
3259230-8	1988	When protein synthesis was blocked by either cycloheximide, puromycin, or emetine, the induction of alpha 1-acid glycoprotein mRNA by recombinant human interleukin-1 beta was impaired suggesting the involvement of a short-lived protein in the induction of alpha 1-acid glycoprotein mRNA.	Emetine	74-81	interleukin 1 beta	Homo sapiens	152-170
3258319-5	1988	These responses were prevented by ibuprofen given 15 min before the IL-1.	Ibuprofen	34-43	interleukin 1 beta	Homo sapiens	68-72
2452159-9	1988	Our results suggest a role for the cAMP-dependent pathway(s) in IL-6 gene activation by TNF and IL-1.	Cyclic AMP	35-39	interleukin 1 beta	Homo sapiens	96-100
3360803-7	1988	We also show that in human synovial fibroblast cultures human recombinant interleukin-1 beta rapidly induces high levels of MMP-3 mRNA and, conversely, that retinoic acid or dexamethasone can suppress the MMP-3 mRNA levels.	Tretinoin	157-170	interleukin 1 beta	Homo sapiens	74-92
2838419-5	1988	However, exposure of monocytes to recombinant IL 1 alpha or IL 1 beta resulted in enhanced generation of superoxide response following stimulation with PMA.	Superoxides	105-115	interleukin 1 beta	Homo sapiens	60-69
2838419-5	1988	However, exposure of monocytes to recombinant IL 1 alpha or IL 1 beta resulted in enhanced generation of superoxide response following stimulation with PMA.	Tetradecanoylphorbol Acetate	152-155	interleukin 1 beta	Homo sapiens	60-69
3257992-2	1988	From 10(-5) to 10(-8) M glucocorticoid hormone (prednisolone) inhibited both IL-1 alpha and IL-1 beta production by LPS-stimulated adherent human PBMC in a dose-dependent fashion, as assayed by Western blotting of cell-associated IL-1 and a thymocyte comitogenic bioassay.	Prednisolone	48-60	interleukin 1 beta	Homo sapiens	92-101
3258335-2	1988	During the course of studies of post-translational modifications of human IL-1, we have observed that although LPS induced the production of both intracellular IL-1 alpha and IL-1 beta in human monocytes, [32P]orthophosphate labeling of these cells revealed that intracellular precursor of IL-1 alpha (pre-IL-1 alpha) to be phosphorylated at least 10-fold more than intracellular pre-IL-1 beta.	Phosphates	210-224	interleukin 1 beta	Homo sapiens	74-78
3257992-2	1988	From 10(-5) to 10(-8) M glucocorticoid hormone (prednisolone) inhibited both IL-1 alpha and IL-1 beta production by LPS-stimulated adherent human PBMC in a dose-dependent fashion, as assayed by Western blotting of cell-associated IL-1 and a thymocyte comitogenic bioassay.	Prednisolone	48-60	interleukin 1 beta	Homo sapiens	77-81
2829892-0	1988	Site-specific mutagenesis of the human interleukin-1 beta gene: structure-function analysis of the cysteine residues.	Cysteine	99-107	interleukin 1 beta	Homo sapiens	39-57
2829892-1	1988	Human interleukin-1 beta (IL-1 beta) has two cysteines located at amino acid residues 8 and 71 of the mature protein consisting 153 amino acids.	Cysteine	45-54	interleukin 1 beta	Homo sapiens	6-24
2829892-1	1988	Human interleukin-1 beta (IL-1 beta) has two cysteines located at amino acid residues 8 and 71 of the mature protein consisting 153 amino acids.	Cysteine	45-54	interleukin 1 beta	Homo sapiens	26-35
2829892-2	1988	To clarify the role of these characteristic cysteine residues in IL-1 beta, at first, an expression plasmid for site-specific mutagenesis has been constructed by inserting the ori and intergenic region of phage f1 into the IL-1 beta expression vector.	Cysteine	44-52	interleukin 1 beta	Homo sapiens	65-74
2829892-4	1988	Using this plasmid, each of the cysteine codons in IL-1 beta gene was changed to serine or alanine codon, or deleted.	Cysteine	32-40	interleukin 1 beta	Homo sapiens	51-60
2829892-4	1988	Using this plasmid, each of the cysteine codons in IL-1 beta gene was changed to serine or alanine codon, or deleted.	Serine	81-87	interleukin 1 beta	Homo sapiens	51-60
2829892-4	1988	Using this plasmid, each of the cysteine codons in IL-1 beta gene was changed to serine or alanine codon, or deleted.	Alanine	91-98	interleukin 1 beta	Homo sapiens	51-60
2829892-5	1988	The modified IL-1 beta showed that the two cysteine residues in IL-1 beta are not essential for biological activity but not to be eliminated for the maintenance of the functional structure of IL-1 beta.	Cysteine	43-51	interleukin 1 beta	Homo sapiens	13-22
3128273-3	1988	Prostaglandin E production was stimulated predominantly by IL1 alpha and IL1 beta rather than by IFN-gamma or TNF alpha.	Prostaglandins E	0-15	interleukin 1 beta	Homo sapiens	73-81
2829892-5	1988	The modified IL-1 beta showed that the two cysteine residues in IL-1 beta are not essential for biological activity but not to be eliminated for the maintenance of the functional structure of IL-1 beta.	Cysteine	43-51	interleukin 1 beta	Homo sapiens	64-73
2829892-5	1988	The modified IL-1 beta showed that the two cysteine residues in IL-1 beta are not essential for biological activity but not to be eliminated for the maintenance of the functional structure of IL-1 beta.	Cysteine	43-51	interleukin 1 beta	Homo sapiens	64-73
3257575-2	1988	Phorbol ester and lipopolysaccharide increased the steady-state level of IL-1 beta mRNA.	Phorbol Esters	0-13	interleukin 1 beta	Homo sapiens	73-82
3257219-0	1988	Dexamethasone inhibition of interleukin 1 beta production by human monocytes.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	28-46
3289586-4	1988	Using the E. coli tryptophan promoter control of transcription, a 2.2 g/l production level of IL-1 beta was achieved in E. coli B at cell densities of 55 g dry weight per litre.	Tryptophan	18-28	interleukin 1 beta	Homo sapiens	94-103
3264778-5	1988	The rate of [35S]-sulfate incorporation into proteoglycans by human gingival fibroblasts was enhanced by 40% at 10(-9) M IL-1 beta.	Sulfur-35	13-16	interleukin 1 beta	Homo sapiens	121-130
3264778-5	1988	The rate of [35S]-sulfate incorporation into proteoglycans by human gingival fibroblasts was enhanced by 40% at 10(-9) M IL-1 beta.	Sulfates	18-25	interleukin 1 beta	Homo sapiens	121-130
3264778-6	1988	This stimulatory effect appeared to be independent of cell proliferation and prostaglandin synthesis since blocking of these functions with hydroxyurea and indomethacin respectively, resulted in similar dose responses to IL-1 beta.	Hydroxyurea	140-151	interleukin 1 beta	Homo sapiens	221-230
3264778-6	1988	This stimulatory effect appeared to be independent of cell proliferation and prostaglandin synthesis since blocking of these functions with hydroxyurea and indomethacin respectively, resulted in similar dose responses to IL-1 beta.	Indomethacin	156-168	interleukin 1 beta	Homo sapiens	221-230
3257219-6	1988	Posttranscriptionally, dexamethasone was found to have multiple effects: slight prolongation of IL-1 beta mRNA half-life, moderate inhibition of translation of the IL-1 beta precursor, and profound inhibition of the release of IL-1 beta into the extracellular fluid.	Dexamethasone	23-36	interleukin 1 beta	Homo sapiens	96-105
3257219-6	1988	Posttranscriptionally, dexamethasone was found to have multiple effects: slight prolongation of IL-1 beta mRNA half-life, moderate inhibition of translation of the IL-1 beta precursor, and profound inhibition of the release of IL-1 beta into the extracellular fluid.	Dexamethasone	23-36	interleukin 1 beta	Homo sapiens	164-173
3257219-6	1988	Posttranscriptionally, dexamethasone was found to have multiple effects: slight prolongation of IL-1 beta mRNA half-life, moderate inhibition of translation of the IL-1 beta precursor, and profound inhibition of the release of IL-1 beta into the extracellular fluid.	Dexamethasone	23-36	interleukin 1 beta	Homo sapiens	164-173
2967366-0	1988	The effect of interleukin-1 beta on hyaluronic acid synthesized by adult human gingival fibroblasts in vitro.	Hyaluronic Acid	36-51	interleukin 1 beta	Homo sapiens	14-32
3257219-2	1988	Dexamethasone is known to have an inhibitory effect on IL-1 production.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	55-59
2826581-4	1987	Northern blot hybridization analysis indicated that Dex, 10 nM, completely blocked accumulation of IL-1 beta-encoding mRNA in U937 cells.	Dexamethasone	52-55	interleukin 1 beta	Homo sapiens	99-108
3145372-3	1988	A simple chloroform extraction process has been developed which eliminates several of the interfering factors from plasma samples and increases the amount of IL-1 beta detected by radioimmunoassay and lymphocyte activation assay.	Chloroform	9-19	interleukin 1 beta	Homo sapiens	158-167
3145372-7	1988	We propose that plasma samples collected with EDTA and aprotinin provide a better determination of free circulating IL-1 beta in vivo than serum samples, which may contain IL-1 beta secreted from blood leukocytes during the clotting process.	Edetic Acid	46-50	interleukin 1 beta	Homo sapiens	116-125
3119705-15	1987	Enhanced prostaglandin synthesis may play a role in the IL-1- and TNF-induced suppression of accessory cell function, but other factors are likely to be involved.	Prostaglandins	9-22	interleukin 1 beta	Homo sapiens	56-60
3499974-4	1987	This interleukin 1 (IL-1)-like activity exactly coeluted with BRA upon gel chromatography, DEAE-Sepharose ion-exchange chromatography, and isoelectric focusing (pI, 4.7-5.2).	deae-sepharose	91-105	interleukin 1 beta	Homo sapiens	5-24
3500170-8	1987	These cells were more responsive to the hIL-1 beta preparation than to the mIL-1 alpha (half-maximal stimulation of PGE2 production was observed at approximately 2.5-5 pM hIL-1 beta and at approximately 2.5 nM mIL-1 alpha).	Dinoprostone	116-120	interleukin 1 beta	Homo sapiens	40-50
3500170-8	1987	These cells were more responsive to the hIL-1 beta preparation than to the mIL-1 alpha (half-maximal stimulation of PGE2 production was observed at approximately 2.5-5 pM hIL-1 beta and at approximately 2.5 nM mIL-1 alpha).	Dinoprostone	116-120	interleukin 1 beta	Homo sapiens	171-181
3500955-3	1987	Dexamethasone increases the specific activity of alkaline phosphatase in a time- and dose-dependent fashion (maximum 14-fold induction at 10(-6) M, IC50 = 10(-8) M), and this induction can be completely inhibited by simultaneous incubation with picomolar concentrations of recombinant human IL-1 alpha or IL-1 beta.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	305-314
3316383-4	1987	Arachidonic acid metabolites are implicated as biochemical intermediates in the production of the neutrophilia but not lymphopenia, since indomethacin and dexamethasone both completely abrogated IL-1-induced neutrophilia but did not affect the IL-1-induced lymphopenia.	Arachidonic Acid	0-16	interleukin 1 beta	Homo sapiens	195-199
3316383-4	1987	Arachidonic acid metabolites are implicated as biochemical intermediates in the production of the neutrophilia but not lymphopenia, since indomethacin and dexamethasone both completely abrogated IL-1-induced neutrophilia but did not affect the IL-1-induced lymphopenia.	Arachidonic Acid	0-16	interleukin 1 beta	Homo sapiens	244-248
3316383-4	1987	Arachidonic acid metabolites are implicated as biochemical intermediates in the production of the neutrophilia but not lymphopenia, since indomethacin and dexamethasone both completely abrogated IL-1-induced neutrophilia but did not affect the IL-1-induced lymphopenia.	Indomethacin	138-150	interleukin 1 beta	Homo sapiens	195-199
3316383-4	1987	Arachidonic acid metabolites are implicated as biochemical intermediates in the production of the neutrophilia but not lymphopenia, since indomethacin and dexamethasone both completely abrogated IL-1-induced neutrophilia but did not affect the IL-1-induced lymphopenia.	Indomethacin	138-150	interleukin 1 beta	Homo sapiens	244-248
3316383-4	1987	Arachidonic acid metabolites are implicated as biochemical intermediates in the production of the neutrophilia but not lymphopenia, since indomethacin and dexamethasone both completely abrogated IL-1-induced neutrophilia but did not affect the IL-1-induced lymphopenia.	Dexamethasone	155-168	interleukin 1 beta	Homo sapiens	195-199
3316383-4	1987	Arachidonic acid metabolites are implicated as biochemical intermediates in the production of the neutrophilia but not lymphopenia, since indomethacin and dexamethasone both completely abrogated IL-1-induced neutrophilia but did not affect the IL-1-induced lymphopenia.	Dexamethasone	155-168	interleukin 1 beta	Homo sapiens	244-248
3497982-15	1987	Adding indomethacin to the cultures prevented the decreased production of IL-1-beta induced by high concentrations of IL-1-alpha.	Indomethacin	7-19	interleukin 1 beta	Homo sapiens	74-83
3501509-4	1987	or s.c. A dose-dependent enhancement of the primary response to SRBC was also observed when IL-1 beta or its peptide fragment were injected intravenously (i.v.)	srbc	64-68	interleukin 1 beta	Homo sapiens	92-101
3497983-7	1987	Actinomycin D prevented the appearance of IL-1 mRNA in rIL-1-treated EC.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	42-46
3497983-8	1987	rIL-1 also induced the release of biologically active IL-1 from EC, which was inhibited by cycloheximide (1 microgram/ml).	Cycloheximide	91-104	interleukin 1 beta	Homo sapiens	1-5
3497983-10	1987	EC stimulated with rIL-1 produced prostaglandin E2, which inhibits IL-1 production by other cell types and also decreases the responsiveness of thymocytes to IL-1.	Dinoprostone	34-50	interleukin 1 beta	Homo sapiens	20-24
3497983-10	1987	EC stimulated with rIL-1 produced prostaglandin E2, which inhibits IL-1 production by other cell types and also decreases the responsiveness of thymocytes to IL-1.	Dinoprostone	34-50	interleukin 1 beta	Homo sapiens	67-71
3497983-11	1987	When EC were exposed to rIL-1 in the presence of indomethacin (1 microgram/ml), which blocked prostaglandin E2 production, greater amounts of rIL-1-induced IL-1 release were detected, although the inhibitor did not affect IL-1-beta mRNA levels.	Indomethacin	49-61	interleukin 1 beta	Homo sapiens	25-29
3306235-1	1987	Il-1, a multifunctional monokine, can stimulate both synoviocytes and articular chondrocytes to release neutral proteases and prostaglandin E2.	Dinoprostone	126-142	interleukin 1 beta	Homo sapiens	0-4
3497983-11	1987	When EC were exposed to rIL-1 in the presence of indomethacin (1 microgram/ml), which blocked prostaglandin E2 production, greater amounts of rIL-1-induced IL-1 release were detected, although the inhibitor did not affect IL-1-beta mRNA levels.	Indomethacin	49-61	interleukin 1 beta	Homo sapiens	222-231
3497983-11	1987	When EC were exposed to rIL-1 in the presence of indomethacin (1 microgram/ml), which blocked prostaglandin E2 production, greater amounts of rIL-1-induced IL-1 release were detected, although the inhibitor did not affect IL-1-beta mRNA levels.	Dinoprostone	94-110	interleukin 1 beta	Homo sapiens	25-29
3497983-11	1987	When EC were exposed to rIL-1 in the presence of indomethacin (1 microgram/ml), which blocked prostaglandin E2 production, greater amounts of rIL-1-induced IL-1 release were detected, although the inhibitor did not affect IL-1-beta mRNA levels.	ril-1	24-29	interleukin 1 beta	Homo sapiens	222-231
3301852-3	1987	The recombinant IL-1 beta was characterized by amino acid analysis, NH2- and COOH-terminal sequence analysis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, spectroscopy, and biological assay.	Sodium Dodecyl Sulfate	110-132	interleukin 1 beta	Homo sapiens	16-25
3305504-1	1987	Recombinant human interleukin 1 beta which is expressed in Escherichia coli has been crystallized by the method of vapor diffusion using ammonium sulfate as the precipitant.	Ammonium Sulfate	137-153	interleukin 1 beta	Homo sapiens	18-36
3301852-3	1987	The recombinant IL-1 beta was characterized by amino acid analysis, NH2- and COOH-terminal sequence analysis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, spectroscopy, and biological assay.	polyacrylamide	133-147	interleukin 1 beta	Homo sapiens	16-25
3495602-3	1987	No demonstrable IL-1 beta protein could be observed on the cell surface by antibody staining, while both IL-1 alpha and IL-1 beta could be visualized intracellularly by the appropriate monoclonal antibodies following acetone permeabilization of the monocytes.	Acetone	217-224	interleukin 1 beta	Homo sapiens	120-129
3304720-5	1987	The molecular weight of hIL-1 beta in normal urine was shown to be 17,000 by gel filtration, and levels of urine hIL-1 beta in healthy subjects aged 19-87 yr were 0-146 ng/1 or 0-88 ng/g of creatinine.	Creatinine	190-200	interleukin 1 beta	Homo sapiens	24-34
3304720-5	1987	The molecular weight of hIL-1 beta in normal urine was shown to be 17,000 by gel filtration, and levels of urine hIL-1 beta in healthy subjects aged 19-87 yr were 0-146 ng/1 or 0-88 ng/g of creatinine.	Creatinine	190-200	interleukin 1 beta	Homo sapiens	113-123
3496595-4	1987	Addition of cycloheximide to recombinant (r)IL-1 beta and rTNF further enhances the level of 26-kDa-protein mRNA.	Cycloheximide	12-25	interleukin 1 beta	Homo sapiens	44-53
3034257-3	1987	Interleukin 1 beta or phorbol ester increased the levels of procollagenase (assayed after trypsin activation) and the labeling of several medium proteins by cells incubated with [35S]methionine, independent of prostaglandin synthesis.	Methionine	183-193	interleukin 1 beta	Homo sapiens	0-18
3495574-3	1987	We characterized the effects on PG production by confluent normal lung fibroblasts of recombinant interleukin 1 alpha (IL 1 alpha), interleukin 1 beta (IL 1 beta) and tumor necrosis factor (TNF), alone and in combination.	Prostaglandins	32-34	interleukin 1 beta	Homo sapiens	132-150
3494764-0	1987	Augmentation of IL 1-induced fibroblast PGE2 production by a urine-derived IL 1 inhibitor.	Dinoprostone	40-44	interleukin 1 beta	Homo sapiens	16-20
3494764-3	1987	We examined the effect of one well-characterized inhibitor of IL 1, isolated from the urine of febrile patients, on a second IL 1 effect, stimulation of fibroblast PGE synthesis.	Prostaglandins E	164-167	interleukin 1 beta	Homo sapiens	125-129
3494764-5	1987	Rather, inhibitor preparations markedly enhanced fibroblast PGE synthetic responses to IL 1.	Prostaglandins E	60-63	interleukin 1 beta	Homo sapiens	87-91
3494764-7	1987	Augmentation of the IL 1-induced PGE response was seen with both low (1:1 unit) and high (400:1) ratios of inhibitor to IL 1.	Prostaglandins E	33-36	interleukin 1 beta	Homo sapiens	20-24
3494764-7	1987	Augmentation of the IL 1-induced PGE response was seen with both low (1:1 unit) and high (400:1) ratios of inhibitor to IL 1.	Prostaglandins E	33-36	interleukin 1 beta	Homo sapiens	120-124
3494766-9	1987	In contrast to the actions of LT or TNF, pretreatment with IL 1 alpha or IL 1 beta only partially inhibited induction of H4/18 binding by phorbol ester, and phorbol ester pretreatment consistently, albeit partially, inhibited induction by IL 1 species.	Phorbol Esters	138-151	interleukin 1 beta	Homo sapiens	73-82
3555119-4	1987	In the present work, we have studied whether human recombinant interleukin-1 beta (hrIL-1) could affect the renal handling of sodium and thus, could be implicated in natriuretic response to pyrogens or endotoxins.	Sodium	126-132	interleukin 1 beta	Homo sapiens	63-81
3494774-3	1987	The human astrocytoma U373 was found to incorporate [3H]thymidine after exposure to recombinant human IL 1 alpha and IL 1 beta and murine IL 1 alpha.	3h]thymidine	53-65	interleukin 1 beta	Homo sapiens	117-126
3494807-5	1987	Actinomycin D (1 microgram/ml) prevented the induction of IL-1 beta mRNA by rIL-1.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	58-67
3494807-8	1987	Release of IL-1 activity in the extracellular medium began after 1 h of incubation with rIL-1 beta or rIL-1 alpha, and continued for up to 24 h. Anti-TNF antiserum that neutralized the biological activity of rTNF did not affect rIL-1-induced production of IL-1 beta mRNA or IL-1 release, suggesting that the release of TNF does not mediate these processes.	ril-1	88-93	interleukin 1 beta	Homo sapiens	11-15
3109443-0	1987	Interleukin-1 beta and interleukin-1 alpha stimulate the plasminogen activator activity and prostaglandin E2 levels of human synovial cells.	Dinoprostone	92-108	interleukin 1 beta	Homo sapiens	0-18
3109443-3	1987	We report here that samples of purified human interleukin-1 beta (IL-1 beta) and recombinant IL-1 alpha stimulate both the plasminogen activator activity and prostaglandin E2 levels of human synovial fibroblast-like cells.	Dinoprostone	158-174	interleukin 1 beta	Homo sapiens	46-64
3109443-3	1987	We report here that samples of purified human interleukin-1 beta (IL-1 beta) and recombinant IL-1 alpha stimulate both the plasminogen activator activity and prostaglandin E2 levels of human synovial fibroblast-like cells.	Dinoprostone	158-174	interleukin 1 beta	Homo sapiens	66-75
3109443-5	1987	The elevation in plasminogen activator activity was inhibited by indomethacin, and this suggests that endogenous prostanoids are important in the IL-1-mediated stimulation of proteinase activity.	Indomethacin	65-77	interleukin 1 beta	Homo sapiens	146-150
3109443-5	1987	The elevation in plasminogen activator activity was inhibited by indomethacin, and this suggests that endogenous prostanoids are important in the IL-1-mediated stimulation of proteinase activity.	Prostaglandins	113-124	interleukin 1 beta	Homo sapiens	146-150
3494508-2	1987	Purified human IL 1 beta appeared to be growth inhibitory (maximum, 50%) for M1 cells based on cell counts and [3H]thymidine incorporation.	Tritium	112-114	interleukin 1 beta	Homo sapiens	15-24
3494508-2	1987	Purified human IL 1 beta appeared to be growth inhibitory (maximum, 50%) for M1 cells based on cell counts and [3H]thymidine incorporation.	Thymidine	115-124	interleukin 1 beta	Homo sapiens	15-24
3034257-3	1987	Interleukin 1 beta or phorbol ester increased the levels of procollagenase (assayed after trypsin activation) and the labeling of several medium proteins by cells incubated with [35S]methionine, independent of prostaglandin synthesis.	Prostaglandins	210-223	interleukin 1 beta	Homo sapiens	0-18
3104452-6	1987	Our findings are consistent with the concept that Leu-5b delivers a signal to IL 2-responsive cells that prevents their subsequent proliferation and development of cytotoxicity, but that only the former event, i.e., proliferation, is reconstituted by the addition of IL 1 beta.	Leucine	50-53	interleukin 1 beta	Homo sapiens	267-276
3034296-1	1987	Human recombinant interleukin-1 beta (rIL-1 beta) stimulated glycosaminoglycan (GAG) production in human synovial fibroblast cultures.	Glycosaminoglycans	61-78	interleukin 1 beta	Homo sapiens	18-36
3494060-2	1987	Demonstration of IL 1 activity was based on the ability of TNF-treated FS-4 cells, subsequently fixed with formaldehyde, to stimulate thymocyte proliferation in the presence of phytohemagglutinin.	Formaldehyde	107-119	interleukin 1 beta	Homo sapiens	17-21
3494060-6	1987	Dexamethasone suppressed the synthesis of TNF-induced MA-IL 1.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	57-61
3493322-3	1987	First, poly(A)-rich RNA extracted from IL-1-treated cells could be enriched in HPGF-mRNA content by hybridization to 26 kD cDNA.	Poly A	7-14	interleukin 1 beta	Homo sapiens	39-43
3493286-6	1987	Preincubation with specific antisera to native human IL 1 or rIL 1 reduced by 75 to 100% the activity of MCM in stimulating endothelial cell release of BPA, GM-CSA, Meg-CSA, and mixed-cell CSA.	bisphenol A	152-155	interleukin 1 beta	Homo sapiens	53-57
3311846-4	1987	Decrease in antigen-positive cells is delayed in LPS/TNF versus IL-1-alpha, beta/TPA-induced antigen expression (LPS vs. IL-1-beta: 60% vs. 5% at 24 h).	(2-benzoylethyl)trimethylammonium	76-80	interleukin 1 beta	Homo sapiens	121-130
2949012-6	1987	Native and rIL 1 beta co-migrated on SDS-polyacrylamide gels as 17.5 kd polypeptides and reacted with specific polyclonal antisera raised to three synthetic peptides of human IL 1 beta in immunoblot experiments.	Sodium Dodecyl Sulfate	37-40	interleukin 1 beta	Homo sapiens	12-21
2949012-6	1987	Native and rIL 1 beta co-migrated on SDS-polyacrylamide gels as 17.5 kd polypeptides and reacted with specific polyclonal antisera raised to three synthetic peptides of human IL 1 beta in immunoblot experiments.	polyacrylamide	41-55	interleukin 1 beta	Homo sapiens	12-21
3542082-5	1987	PGI2 and PCA were elicited by "22K factor" and by human recombinant IL 1 beta and alpha but not by murine recombinant IL 1 alpha.	Epoprostenol	0-4	interleukin 1 beta	Homo sapiens	68-77
3311846-4	1987	Decrease in antigen-positive cells is delayed in LPS/TNF versus IL-1-alpha, beta/TPA-induced antigen expression (LPS vs. IL-1-beta: 60% vs. 5% at 24 h).	Tetradecanoylphorbol Acetate	81-84	interleukin 1 beta	Homo sapiens	121-130
2824799-2	1987	Comparative studies revealed that a beta form of recombinant human IL-1, similar to the mature peptide secreted naturally, is more powerful than other preparations of this monokine in stimulating adrenocorticotrophic hormone (ACTH) and corticosterone output.	Corticosterone	236-250	interleukin 1 beta	Homo sapiens	67-71
2433374-4	1987	Following treatment with AZA, U937.1 cells could be induced to produce IL-1 beta mRNA and release IL-1, but only if a stimulus such as LPS was present.	Azacitidine	25-28	interleukin 1 beta	Homo sapiens	71-80
2433374-5	1987	In addition, the level of IL-1 beta mRNA produced and IL-1 released by THP-1 cells after induction could be doubled by treatment with AZA.	Azacitidine	134-137	interleukin 1 beta	Homo sapiens	26-35
2947968-1	1987	Native human IL-1 beta and IL-1 alpha stimulated prostaglandin E2 secretion by human embryonic lung fibroblasts at half-maximal concentrations of 3 +/- 1.2 pM (+/- SEM) and 10 +/- 2.3 pM, respectively.	Dinoprostone	49-65	interleukin 1 beta	Homo sapiens	13-22
2947968-6	1987	Comparison of the biological response curves and binding curves obtained for IL-1 alpha and IL-1 beta showed that they were parallel and that 10-15% occupancy of the estimated 3,000 sites by either species of IL-1 was sufficient to give half-maximal stimulation of prostaglandin E2 secretion.	Dinoprostone	265-281	interleukin 1 beta	Homo sapiens	92-101
2947968-6	1987	Comparison of the biological response curves and binding curves obtained for IL-1 alpha and IL-1 beta showed that they were parallel and that 10-15% occupancy of the estimated 3,000 sites by either species of IL-1 was sufficient to give half-maximal stimulation of prostaglandin E2 secretion.	Dinoprostone	265-281	interleukin 1 beta	Homo sapiens	77-81
2945861-0	1986	Down-regulation of interleukin 1 (IL 1) receptor expression by IL 1 and fate of internalized 125I-labeled IL 1 beta in a human large granular lymphocyte cell line.	Iodine-125	93-97	interleukin 1 beta	Homo sapiens	106-115
3023086-0	1986	A 1H-NMR study of human interleukin-1 beta.	Hydrogen	2-4	interleukin 1 beta	Homo sapiens	24-42
3023484-1	1986	The tumor co-promotor TPA is believed to enhance a wide variety of cellular processes by interacting with protein kinase C. Interleukin (IL 1) is a family of highly active molecules which augments the host response to infection.	Tetradecanoylphorbol Acetate	22-25	interleukin 1 beta	Homo sapiens	137-141
3023484-4	1986	Superoxide anion production by eosinophils stimulated with standard doses of the stimulant phorbol myristic acetate (TPA) (1 microgram/ml) was augmented approximately 20% by preincubation with IL 1.	Superoxides	0-16	interleukin 1 beta	Homo sapiens	193-197
3023484-4	1986	Superoxide anion production by eosinophils stimulated with standard doses of the stimulant phorbol myristic acetate (TPA) (1 microgram/ml) was augmented approximately 20% by preincubation with IL 1.	phorbol myristic acetate	91-115	interleukin 1 beta	Homo sapiens	193-197
3023484-4	1986	Superoxide anion production by eosinophils stimulated with standard doses of the stimulant phorbol myristic acetate (TPA) (1 microgram/ml) was augmented approximately 20% by preincubation with IL 1.	Tetradecanoylphorbol Acetate	117-120	interleukin 1 beta	Homo sapiens	193-197
3023484-6	1986	At suboptimal doses of TPA, there was a dose-dependent inhibition of superoxide anion production in the presence of IL 1.	Tetradecanoylphorbol Acetate	23-26	interleukin 1 beta	Homo sapiens	116-120
3023484-6	1986	At suboptimal doses of TPA, there was a dose-dependent inhibition of superoxide anion production in the presence of IL 1.	Superoxides	69-85	interleukin 1 beta	Homo sapiens	116-120
3023484-8	1986	When IL 1 was added to eosinophils stimulated by TPA in the presence of calcium ionophore, there was a dose-dependent increase in superoxide anion production.	Tetradecanoylphorbol Acetate	49-52	interleukin 1 beta	Homo sapiens	5-9
3023484-8	1986	When IL 1 was added to eosinophils stimulated by TPA in the presence of calcium ionophore, there was a dose-dependent increase in superoxide anion production.	Calcium	72-79	interleukin 1 beta	Homo sapiens	5-9
3023484-8	1986	When IL 1 was added to eosinophils stimulated by TPA in the presence of calcium ionophore, there was a dose-dependent increase in superoxide anion production.	Superoxides	130-146	interleukin 1 beta	Homo sapiens	5-9
3023484-14	1986	IL 1 may also modify the response of eosinophils to other stimuli such as ionophore and TPA.	Tetradecanoylphorbol Acetate	88-91	interleukin 1 beta	Homo sapiens	0-4
3021848-1	1986	The effect of prostaglandins and cyclic 3",5"-adenosine monophosphate (cAMP) on expression of human interleukin 1 (IL 1) activity was investigated in the promonocytic tumor cell line U937 and peripheral blood monocytes.	Prostaglandins	14-28	interleukin 1 beta	Homo sapiens	100-119
3021848-1	1986	The effect of prostaglandins and cyclic 3",5"-adenosine monophosphate (cAMP) on expression of human interleukin 1 (IL 1) activity was investigated in the promonocytic tumor cell line U937 and peripheral blood monocytes.	cyclic 3",5"-adenosine monophosphate	33-69	interleukin 1 beta	Homo sapiens	100-119
3021848-1	1986	The effect of prostaglandins and cyclic 3",5"-adenosine monophosphate (cAMP) on expression of human interleukin 1 (IL 1) activity was investigated in the promonocytic tumor cell line U937 and peripheral blood monocytes.	Cyclic AMP	71-75	interleukin 1 beta	Homo sapiens	100-119
3488079-2	1986	Lipopolysaccharide, silica, and hydroxyurea by themselves did not induce IL 1 production, but these three stimulants in combination had a synergistic effect on the production of IL 1 by THP-1 cells.	Silicon Dioxide	20-26	interleukin 1 beta	Homo sapiens	178-182
3103171-0	1986	Stimulation of arachidonic acid metabolism: differences in potencies of recombinant human interleukin-1 alpha and interleukin-1 beta on two cell types.	Arachidonic Acid	15-31	interleukin 1 beta	Homo sapiens	114-132
3020090-6	1986	The MCF/IL-1 inhibitor(s), which also acts on human recombinant IL-1 beta, is approximately 25-35 kD, is not retained on concanavalin A-Sepharose column and can be partially destroyed with urea and boiling.	Urea	189-193	interleukin 1 beta	Homo sapiens	64-73
3011895-5	1986	The binding of 125I-IL 1-beta to VDS-O cells was also inhibited by F(ab)"2 fragments of anti-human IL 1 and recombinant human IL 1-alpha, as well as by unlabeled human IL 1-beta but not by recombinant lymphotoxin, recombinant tumor necrosis factor, or phorbol myristic acid, suggesting that IL 1-alpha and IL 1-beta bind specifically to the same receptor.	phorbol-12-myristate	252-273	interleukin 1 beta	Homo sapiens	20-29
3011895-5	1986	The binding of 125I-IL 1-beta to VDS-O cells was also inhibited by F(ab)"2 fragments of anti-human IL 1 and recombinant human IL 1-alpha, as well as by unlabeled human IL 1-beta but not by recombinant lymphotoxin, recombinant tumor necrosis factor, or phorbol myristic acid, suggesting that IL 1-alpha and IL 1-beta bind specifically to the same receptor.	phorbol-12-myristate	252-273	interleukin 1 beta	Homo sapiens	20-24
3488079-3	1986	A 17-kilodalton (kDa) form of human IL 1 with a pI of 7.0 (IL 1-beta) was purified to homogeneity by sequential chromatography on DEAE-Sephacel, Sephacryl S-200, CM high-performance liquid chromatography (HPLC), and hydroxyapatite HPLC.	sephacryl S 200	145-160	interleukin 1 beta	Homo sapiens	36-40
3488079-2	1986	Lipopolysaccharide, silica, and hydroxyurea by themselves did not induce IL 1 production, but these three stimulants in combination had a synergistic effect on the production of IL 1 by THP-1 cells.	Hydroxyurea	32-43	interleukin 1 beta	Homo sapiens	178-182
3488079-3	1986	A 17-kilodalton (kDa) form of human IL 1 with a pI of 7.0 (IL 1-beta) was purified to homogeneity by sequential chromatography on DEAE-Sephacel, Sephacryl S-200, CM high-performance liquid chromatography (HPLC), and hydroxyapatite HPLC.	Durapatite	216-230	interleukin 1 beta	Homo sapiens	36-40
3488079-3	1986	A 17-kilodalton (kDa) form of human IL 1 with a pI of 7.0 (IL 1-beta) was purified to homogeneity by sequential chromatography on DEAE-Sephacel, Sephacryl S-200, CM high-performance liquid chromatography (HPLC), and hydroxyapatite HPLC.	deae-sephacel	130-143	interleukin 1 beta	Homo sapiens	36-40
3010257-3	1985	In this study, we investigated whether purified (human) IL1 influences the specific binding of three prototypic opioid agonists (2-D-alanine-5-L-methionineamide, DAME; (-)-ethylketocyclazocine, EKC; dihydromorphine, DHM) and one antagonist (naloxone) to opioid receptor-enriched membrane preparations in cerebral cortex, hypothalamus, midbrain, pons, medulla, and cerebellum of guinea pig brain.	2-d-alanine-5-l-methionineamide	129-160	interleukin 1 beta	Homo sapiens	56-59
3485152-6	1986	Recombinant IL 1 is capable of stimulating T cell and fibroblast proliferation and inducing fibroblast collagenase and prostaglandin production, thus proving that a single molecule has many of the activities previously ascribed to only partially purified IL 1 preparations.	Prostaglandins	119-132	interleukin 1 beta	Homo sapiens	12-16
3516896-3	1986	We recently have presented data demonstrating that lipoxygenase derived leukotriene B4 and C4 can induce the release of IL-1 by macrophages, while PGE2 and PGI2 can suppress the production of IL-1.	Leukotrienes	72-83	interleukin 1 beta	Homo sapiens	120-124
3516896-3	1986	We recently have presented data demonstrating that lipoxygenase derived leukotriene B4 and C4 can induce the release of IL-1 by macrophages, while PGE2 and PGI2 can suppress the production of IL-1.	Leukotrienes	72-83	interleukin 1 beta	Homo sapiens	192-196
3516896-3	1986	We recently have presented data demonstrating that lipoxygenase derived leukotriene B4 and C4 can induce the release of IL-1 by macrophages, while PGE2 and PGI2 can suppress the production of IL-1.	Dinoprostone	147-151	interleukin 1 beta	Homo sapiens	192-196
3516896-3	1986	We recently have presented data demonstrating that lipoxygenase derived leukotriene B4 and C4 can induce the release of IL-1 by macrophages, while PGE2 and PGI2 can suppress the production of IL-1.	Epoprostenol	156-160	interleukin 1 beta	Homo sapiens	192-196
3517219-1	1986	We have used synthetic peptides coupled to KLH to raise high titer antisera to human IL-1 beta, and in the present report show the usefulness of these sera for immunocytochemical analyses of IL-1 production.	Peptides	23-31	interleukin 1 beta	Homo sapiens	85-94
3517219-1	1986	We have used synthetic peptides coupled to KLH to raise high titer antisera to human IL-1 beta, and in the present report show the usefulness of these sera for immunocytochemical analyses of IL-1 production.	Peptides	23-31	interleukin 1 beta	Homo sapiens	85-89
3010257-3	1985	In this study, we investigated whether purified (human) IL1 influences the specific binding of three prototypic opioid agonists (2-D-alanine-5-L-methionineamide, DAME; (-)-ethylketocyclazocine, EKC; dihydromorphine, DHM) and one antagonist (naloxone) to opioid receptor-enriched membrane preparations in cerebral cortex, hypothalamus, midbrain, pons, medulla, and cerebellum of guinea pig brain.	Ethylketocyclazocine	168-192	interleukin 1 beta	Homo sapiens	56-59
3010257-3	1985	In this study, we investigated whether purified (human) IL1 influences the specific binding of three prototypic opioid agonists (2-D-alanine-5-L-methionineamide, DAME; (-)-ethylketocyclazocine, EKC; dihydromorphine, DHM) and one antagonist (naloxone) to opioid receptor-enriched membrane preparations in cerebral cortex, hypothalamus, midbrain, pons, medulla, and cerebellum of guinea pig brain.	ethyketazocine	194-197	interleukin 1 beta	Homo sapiens	56-59
3010257-3	1985	In this study, we investigated whether purified (human) IL1 influences the specific binding of three prototypic opioid agonists (2-D-alanine-5-L-methionineamide, DAME; (-)-ethylketocyclazocine, EKC; dihydromorphine, DHM) and one antagonist (naloxone) to opioid receptor-enriched membrane preparations in cerebral cortex, hypothalamus, midbrain, pons, medulla, and cerebellum of guinea pig brain.	Dihydromorphine	199-214	interleukin 1 beta	Homo sapiens	56-59
3010257-3	1985	In this study, we investigated whether purified (human) IL1 influences the specific binding of three prototypic opioid agonists (2-D-alanine-5-L-methionineamide, DAME; (-)-ethylketocyclazocine, EKC; dihydromorphine, DHM) and one antagonist (naloxone) to opioid receptor-enriched membrane preparations in cerebral cortex, hypothalamus, midbrain, pons, medulla, and cerebellum of guinea pig brain.	Dihydromorphine	216-219	interleukin 1 beta	Homo sapiens	56-59
3010257-3	1985	In this study, we investigated whether purified (human) IL1 influences the specific binding of three prototypic opioid agonists (2-D-alanine-5-L-methionineamide, DAME; (-)-ethylketocyclazocine, EKC; dihydromorphine, DHM) and one antagonist (naloxone) to opioid receptor-enriched membrane preparations in cerebral cortex, hypothalamus, midbrain, pons, medulla, and cerebellum of guinea pig brain.	Naloxone	241-249	interleukin 1 beta	Homo sapiens	56-59
3010257-6	1985	But in cortex the effect of IL1 on the specific binding of DHM is dose-dependent.	Dihydromorphine	59-62	interleukin 1 beta	Homo sapiens	28-31
6812508-4	1982	Penicillamine at high doses enhanced the action of catabolin, while chloroquine inhibited catabolin"s effect on cartilage.	Chloroquine	68-79	interleukin 1 beta	Homo sapiens	90-99
6812508-4	1982	Penicillamine at high doses enhanced the action of catabolin, while chloroquine inhibited catabolin"s effect on cartilage.	Penicillamine	0-13	interleukin 1 beta	Homo sapiens	51-60
6812508-5	1982	Prednisolone inhibited the production of catabolin without affecting its action.	Prednisolone	0-12	interleukin 1 beta	Homo sapiens	41-50
33813846-11	2021	Inhibition of NETs formation with Cl-amidine decreased mRNA expression of proinflammatory cytokines (intercellular adhesion molecule 1 (ICAM-1), interleukin 1 beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha)) in cerebral arteries.	N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide	34-44	interleukin 1 beta	Homo sapiens	145-163
33899283-7	2021	Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines.	Bialaphos	31-34	interleukin 1 beta	Homo sapiens	200-217
33899283-7	2021	Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines.	Bialaphos	105-108	interleukin 1 beta	Homo sapiens	200-217
32856190-7	2021	The changes of interleukin-1beta levels in the FA group and interleukin-6 levels in the DHA group were significantly less than that in the FA + DHA group (P < 0.05).	Docosahexaenoic Acids	144-147	interleukin 1 beta	Homo sapiens	15-32
34055194-3	2021	The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression through ROS generation in OA chondrocytes.	Dinoprostone	150-154	interleukin 1 beta	Homo sapiens	64-81
33580871-3	2021	Our previous work identified that chronic escalating heroin administration and withdrawal can produce enhanced fear learning, an animal model of hyperarousal, and is associated with an increase in dorsal hippocampal (DH) interleukin-1beta (IL-1beta).	Heroin	53-59	interleukin 1 beta	Homo sapiens	221-238
33846813-2	2021	In the present study, the functional roles of IL-1beta (IL1B) and the inhibitory effect of celastrol on IL1B expression were investigated in triple-negative breast cancer (TNBC) cells.	celastrol	91-100	interleukin 1 beta	Homo sapiens	104-108
33846813-3	2021	The data revealed that celastrol markedly decreased IL1B expression and suppressed TNBC cell proliferation in a dose-dependent manner.	celastrol	23-32	interleukin 1 beta	Homo sapiens	52-56
33846813-7	2021	Celastrol also promoted IL1B downregulation through the suppression of the MEK/ERK-dependent pathway.	celastrol	0-9	interleukin 1 beta	Homo sapiens	24-28
33846813-8	2021	Furthermore, the results also revealed a decrease in IL1B-induced IL8, MMP-1, and MMP-9 expression in response to celastrol treatment.	celastrol	114-123	interleukin 1 beta	Homo sapiens	53-57
33846813-9	2021	The induction of cellular invasion by IL1B was also markedly decreased by celastrol.	celastrol	74-83	interleukin 1 beta	Homo sapiens	38-42
33846813-10	2021	Collectively, the present study results suggested celastrol as an effective drug for the treatment of TNBC, involving a reduction in IL1B expression, activity or signaling pathways.	celastrol	50-59	interleukin 1 beta	Homo sapiens	133-137
34050880-8	2021	In addition, following 15-min tCCAo, pro-inflammatory cytokines [tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta)] immunoreactivity was significantly higher than that seen following 5-min tCCAo, whereas immunoreactivity of anti-inflammatory cytokines (IL-4 and IL-13) was lower in 15-min than 5-min tCCAo.	tccao	30-35	interleukin 1 beta	Homo sapiens	109-127
33955754-5	2021	CBD treatment down-regulated the mRNA expression levels of CASP1 and IL1B (by 32.9 and 51.0%, respectively) and reduced IL-1beta level (by 16.2%) in H2O2-stimulated HaCaT cells.	Cannabidiol	0-3	interleukin 1 beta	Homo sapiens	69-73
34004605-8	2021	Bound caspases-4/5 oligomerize and trigger the assembly of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 inflammasome followed by the activation of inflammatory caspase-1 resulting in subsequent release of interleukin-1beta.	Leucine	90-97	interleukin 1 beta	Homo sapiens	249-266
33179177-0	2021	Periodontal clinical status, microbial profile, and expression of interleukin-1beta in men under androgenic anabolic steroids abuse.	Steroids	117-125	interleukin 1 beta	Homo sapiens	66-83
33949772-7	2021	Moreover, nintedanib treatment inhibited expression of several cytokines/chemokines, including tumour necrosis factor-alpha, interleukin-1beta and interleukin-6, monocyte chemoattractant protein-1 and prevented infiltration of macrophages to the injured peritoneum.	nintedanib	10-20	interleukin 1 beta	Homo sapiens	125-142
34055194-0	2021	PPARgamma Attenuates Interleukin-1beta-Induced Cell Apoptosis by Inhibiting NOX2/ROS/p38MAPK Activation in Osteoarthritis Chondrocytes.	Reactive Oxygen Species	81-84	interleukin 1 beta	Homo sapiens	21-38
34055194-3	2021	The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression through ROS generation in OA chondrocytes.	Dinoprostone	132-148	interleukin 1 beta	Homo sapiens	64-81
34055194-3	2021	The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression through ROS generation in OA chondrocytes.	Reactive Oxygen Species	175-178	interleukin 1 beta	Homo sapiens	64-81
33459949-6	2021	Furthermore, miR-362-3p affected the expression of MAPK1, MAPK3, IL1B and CASP9 in H/R-injured cardiomyocytes through targeting ORM1.	mir-362-3p	13-23	interleukin 1 beta	Homo sapiens	65-69
33737242-4	2021	We show that PE and its derivatives by inducing a rise of intracellular calcium concentration by depolarizing the membrane protect beta-cells against death induced by Interleukin-1beta.	pe	13-15	interleukin 1 beta	Homo sapiens	167-184
32955700-0	2021	Interleukin-1beta, interleukin-6, and interleukin-17A as indicators reflecting clinical response to celecoxib in ankylosing spondylitis patients.	Celecoxib	100-109	interleukin 1 beta	Homo sapiens	0-17
33846227-7	2021	However, at the output of the nucleus, the combination of M-triDAP and LPS synergistically induces expression of a subset of M-triDAP- and LPS-inducible genes, particularly those encoding proinflammatory cytokines (TNF, IL1B, IL6, IL12B, and IL23A).	m-tridap	58-66	interleukin 1 beta	Homo sapiens	220-224
33846227-7	2021	However, at the output of the nucleus, the combination of M-triDAP and LPS synergistically induces expression of a subset of M-triDAP- and LPS-inducible genes, particularly those encoding proinflammatory cytokines (TNF, IL1B, IL6, IL12B, and IL23A).	L-Ala-gamma-D-Glu-meso-diaminopimelic acid	59-66	interleukin 1 beta	Homo sapiens	220-224
33582592-9	2021	The GMSC-Exos group showed lower Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin-6 (IL-6), Interleukin-1beta (IL-1beta), and cluster of differentiation 86 (CD86) expression levels than the high-lipid group, and the highest levels of Interleukin-10 (IL-10) among all groups.	gmsc	4-8	interleukin 1 beta	Homo sapiens	96-113
33737242-4	2021	We show that PE and its derivatives by inducing a rise of intracellular calcium concentration by depolarizing the membrane protect beta-cells against death induced by Interleukin-1beta.	Calcium	72-79	interleukin 1 beta	Homo sapiens	167-184
33902703-14	2021	We propose that CIRP acts as an important proinflammatory stimulant that primes and activates inflammasome and pro-IL-1beta processing in response to uric acid in innate immune cells.	Uric Acid	150-159	interleukin 1 beta	Homo sapiens	111-123
34047081-8	2021	It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment.	Radium	148-150	interleukin 1 beta	Homo sapiens	55-60
33926561-15	2021	Furthermore, Cur-EVs increased gene expression of BCL2, ACAN, SOX9, and COL2A1 and decreased gene expression of IL1B, IL6, MMP13, and COL10A1 in IL-1beta-stimulated OA-CH.	cur-evs	13-20	interleukin 1 beta	Homo sapiens	112-116
34056329-5	2021	Interestingly, Telmisartan inhibited TNF-alpha-induced expression and secretions of proinflammatory mediators such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and monocyte chemotactic protein 1 (MCP-1).	Telmisartan	15-26	interleukin 1 beta	Homo sapiens	118-135
33889075-4	2021	The available data indicates that ATP and glutamate can induce the release of pro inflammatory factors TNF (tumor necrosis factor), IL-1beta (interleukin 1 beta), and NO (nitric oxide) from microglia.	Adenosine Triphosphate	34-37	interleukin 1 beta	Homo sapiens	142-160
33880765-7	2021	Interestingly, ZnFe2 O4 and CrFe2 O4 nanoparticles revealed an excellent anti-inflammatory activity by dose-dependently suppressing mRNA expressions of IL-1b, IL-6, and TNF-alpha.	znfe2 o4	15-23	interleukin 1 beta	Homo sapiens	152-157
33880765-7	2021	Interestingly, ZnFe2 O4 and CrFe2 O4 nanoparticles revealed an excellent anti-inflammatory activity by dose-dependently suppressing mRNA expressions of IL-1b, IL-6, and TNF-alpha.	crfe2 o4	28-36	interleukin 1 beta	Homo sapiens	152-157
33953673-6	2021	Furthermore, HCQ decreased the mRNA expression of interleukin-1beta, corticotropin-releasing hormone (Crh), a serotonin transporter (Slc6a4), and a microglia maker (Aif1) in the hippocampus and decreased the mRNA expression of brain-derived neurotrophic factor (Bdnf) in both the hippocampus and amygdala.	Hydroxychloroquine	13-16	interleukin 1 beta	Homo sapiens	50-67
33917265-10	2021	Production of IL1b, IL6 and TNFalpha dependent on the activation of TLR8 in PBMCs was also increased in patients before DAA treatment, with a significant reduction at week +48.	daa	120-123	interleukin 1 beta	Homo sapiens	14-18
33852854-4	2021	Endogenous GSDME activation permitted sublytic, continuous interleukin-1beta (IL-1beta) release and membrane leakage, even in GSDMD-sufficient cells, whereas ectopic expression led to pyroptosis with GSDME oligomerization and complete liberation of IL-1beta akin to GSDMD pyroptosis.	gsdme	11-16	interleukin 1 beta	Homo sapiens	59-76
33924561-6	2021	In immunomodulatory properties a reduction of interleukin-8 (IL-8) and nitric oxide (NO) release was observed in assays with Caco-2 cells stimulated with interleukin-1beta (1 ng/mL), or lipopolysaccharide (0.1 microg/mL).	Nitric Oxide	71-83	interleukin 1 beta	Homo sapiens	154-171
33912037-0	2021	3"-Sialyllactose Protects SW1353 Chondrocytic Cells From Interleukin-1beta-Induced Oxidative Stress and Inflammation.	3'-sialyllactose	0-16	interleukin 1 beta	Homo sapiens	57-74
33835494-2	2021	The anion Cl- , acting as a second messenger, stimulates the secretion of interleukin-1beta (IL-1beta), which starts an autocrine positive feedback loop.	Anions	4-9	interleukin 1 beta	Homo sapiens	74-91
33889075-4	2021	The available data indicates that ATP and glutamate can induce the release of pro inflammatory factors TNF (tumor necrosis factor), IL-1beta (interleukin 1 beta), and NO (nitric oxide) from microglia.	Glutamic Acid	42-51	interleukin 1 beta	Homo sapiens	142-160
32779379-0	2021	Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1-interleukin 1beta (IL-1beta) pathway.	Carbon	32-38	interleukin 1 beta	Homo sapiens	228-245
33792938-7	2021	Our literature review indicates that at low doses, sumatriptan can reduce inflammatory markers (e.g., interleukin-1beta, tumor necrosis factor-alpha, and nuclear factor-kappaB), affects caspases and changes cells lifespan.	Sumatriptan	51-62	interleukin 1 beta	Homo sapiens	102-119
33867853-8	2021	In addition, inhibition of SIRT3 suppressed titanium particle-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) expression and prevented titanium particle-induced osteolysis and bone loss in vivo.	Titanium	44-52	interleukin 1 beta	Homo sapiens	111-128
33123835-0	2021	Regulation of Apoptosis and Inflammatory Response in Interleukin-1beta-Induced Nucleus Pulposus Cells by miR-125b-5p Via Targeting TRIAP1.	mir-125b-5p	105-116	interleukin 1 beta	Homo sapiens	53-70
33717236-0	2021	Interleukin-1beta weakens paclitaxel sensitivity through regulating autophagy in the non-small cell lung cancer cell line A549.	Paclitaxel	26-36	interleukin 1 beta	Homo sapiens	0-17
32779379-0	2021	Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1-interleukin 1beta (IL-1beta) pathway.	Reactive Oxygen Species	89-112	interleukin 1 beta	Homo sapiens	228-245
32779379-0	2021	Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1-interleukin 1beta (IL-1beta) pathway.	Reactive Oxygen Species	114-117	interleukin 1 beta	Homo sapiens	228-245
33501684-8	2021	Tomentosin further inhibited the inflammatory transcription factors such as nuclear factor kappaB (NF-kappaB), tumor necrosis factor alpha, interleukin 1beta (IL-1beta), and IL-6.	tomentosin	0-10	interleukin 1 beta	Homo sapiens	140-157
33910693-6	2021	Anti-IL-1 therapy must be considered as a second line treatment in case of persistent inflammation or colchicine intolerance.	Colchicine	102-112	interleukin 1 beta	Homo sapiens	5-9
33492610-7	2021	Priming the activation of the NLRP3 inflammasome, mtDAMPs promote secretion of proinflammatory cytokines, including interleukin-1beta (IL-1beta), implicated in atherosclerotic lesions through vascular smooth muscle and fibroblast proliferation, arterial wall thickening, and plaque formation.	mtdamps	50-57	interleukin 1 beta	Homo sapiens	116-133
33314719-10	2021	RESULTS: Interleukin-1beta-treated NPC had a higher percentage of SA-beta-gal positive cells (45%) than the control group (20%) and showed an increase in the relative expression of P16, P21, and P53 (P < 0.05).	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	66-77	interleukin 1 beta	Homo sapiens	9-26
33781818-4	2021	Two nanoparticle types, 200 kDa N,O-carboxymethyl chitosan-HACC (NO-CMC-HACC) and N-carboxymethyl chitosan-HACC (N-CMC-HACC), greatly promoted the expression of interleukin-6, tumor necrosis factor, and interleukin-1beta in DCs.	O,N-carboxymethylchitosan	32-58	interleukin 1 beta	Homo sapiens	203-220
33998893-5	2021	Relative to the LPS-activated and untreated control (M[LPS]), both 25 muM CBD and 10 muM Dex reduced expression of pro-inflammatory markers-tumor necrosis factor alpha, interleukin 1 beta, and regulated on activation, normal T cell expressed and secreted (RANTES)-as well as the pleiotropic marker interleukin-6 (IL-6).	Cannabidiol	74-77	interleukin 1 beta	Homo sapiens	169-187
33677475-7	2021	Moreover, interleukin-1beta (IL-1beta) showed a potential to activate the chloride current of normal chondrocytes.	Chlorides	74-82	interleukin 1 beta	Homo sapiens	10-27
33677475-0	2021	Interleukin 1 beta-induced chloride currents are important in osteoarthritis onset: an in vitro study.	Chlorides	27-35	interleukin 1 beta	Homo sapiens	0-18
33998893-5	2021	Relative to the LPS-activated and untreated control (M[LPS]), both 25 muM CBD and 10 muM Dex reduced expression of pro-inflammatory markers-tumor necrosis factor alpha, interleukin 1 beta, and regulated on activation, normal T cell expressed and secreted (RANTES)-as well as the pleiotropic marker interleukin-6 (IL-6).	Dexamethasone	89-92	interleukin 1 beta	Homo sapiens	169-187
33493484-11	2021	Cell experiments showed that rosuvastatin could reduce the expression of IL-1B in HUVEC and THP-1 cells.	Rosuvastatin Calcium	29-41	interleukin 1 beta	Homo sapiens	73-78
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Anthraquinones	90-103	interleukin 1 beta	Homo sapiens	131-148
32602556-10	2021	Reduced secretion of interleukin-1beta likely by enhanced isoprenylation, and increased unsaturated fatty acid synthesis, both pathways upstream of SQS, likely masked the effect of reduced levels of ASTR-derived cholesterol.	Cholesterol	212-223	interleukin 1 beta	Homo sapiens	21-38
33707963-4	2021	However, overproduction of ROS is most frequently due to excessive stimulation of either the mitochondrial electron transport chain and xanthine oxidase or reduced nicotinamide adenine dinucleotide phosphate (NADPH) by pro-inflammatory cytokines, such as interleukin-1beta and tumor necrosis factor alpha.	Reactive Oxygen Species	27-30	interleukin 1 beta	Homo sapiens	255-272
33707963-4	2021	However, overproduction of ROS is most frequently due to excessive stimulation of either the mitochondrial electron transport chain and xanthine oxidase or reduced nicotinamide adenine dinucleotide phosphate (NADPH) by pro-inflammatory cytokines, such as interleukin-1beta and tumor necrosis factor alpha.	NADP	164-207	interleukin 1 beta	Homo sapiens	255-272
33707963-4	2021	However, overproduction of ROS is most frequently due to excessive stimulation of either the mitochondrial electron transport chain and xanthine oxidase or reduced nicotinamide adenine dinucleotide phosphate (NADPH) by pro-inflammatory cytokines, such as interleukin-1beta and tumor necrosis factor alpha.	NADP	209-214	interleukin 1 beta	Homo sapiens	255-272
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Emodin	30-32	interleukin 1 beta	Homo sapiens	131-148
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Hydrogen Peroxide	211-215	interleukin 1 beta	Homo sapiens	131-148
33669901-4	2021	ND islet cells were exposed to interleukin-1beta and interferon-gamma for up to 120 h. In T1D islets, we confirmed an increased prevalence of Ins+/Glu+ cells.	Glutamic Acid	147-150	interleukin 1 beta	Homo sapiens	31-48
33616827-8	2021	Fisetin treatment alleviated cell injury and suppressed the inflammatory cytokines (interleukin-1 (IL-1), tumor necrosis factor- alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2), interleukin-16 (IL-6), and prostaglandin E2 (PGE2)) and antioxidant parameters in a dose-dependent manner.	fisetin	0-7	interleukin 1 beta	Homo sapiens	188-205
33669995-5	2021	Antioxidants, docosahexaenoic acid (DHA), and vitamin D, have potential for suppressing microglial production of interleukin-1beta, which potentiates the neurotoxicity of amyloid beta.	Docosahexaenoic Acids	14-34	interleukin 1 beta	Homo sapiens	113-130
33669995-5	2021	Antioxidants, docosahexaenoic acid (DHA), and vitamin D, have potential for suppressing microglial production of interleukin-1beta, which potentiates the neurotoxicity of amyloid beta.	Docosahexaenoic Acids	36-39	interleukin 1 beta	Homo sapiens	113-130
33669995-5	2021	Antioxidants, docosahexaenoic acid (DHA), and vitamin D, have potential for suppressing microglial production of interleukin-1beta, which potentiates the neurotoxicity of amyloid beta.	Vitamin D	46-55	interleukin 1 beta	Homo sapiens	113-130
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Paroxetine	34-44	interleukin 1 beta	Homo sapiens	372-389
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Fluoxetine	46-56	interleukin 1 beta	Homo sapiens	372-389
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Sertraline	58-68	interleukin 1 beta	Homo sapiens	372-389
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Citalopram	70-80	interleukin 1 beta	Homo sapiens	372-389
33602262-7	2021	RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta).	Fluvoxamine	86-97	interleukin 1 beta	Homo sapiens	372-389
33053467-4	2021	HUVECs exposed with SiO2 NPs generate excess amount of reactive oxygen species (ROS) and lactate dehydrogenase (LDH), together with the up-regulation of cell inflammatory factors [interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), tumor necrotic factor-alpha (TNF-alpha)] and cell adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)].	Silicon Dioxide	20-24	interleukin 1 beta	Homo sapiens	180-198
33598775-6	2021	RESULTS: FCX significantly decreased LPS-induced interleukin (Il)6, Il1b, and tumor necrosis factor alpha (Tnf) mRNA abundance and TNFalpha secretion.	fucoxanthin	9-12	interleukin 1 beta	Homo sapiens	68-72
33583094-7	2021	Interestingly, when keratinocytes were stimulated with a TLR3 agonist, RGRN-305 also demonstrated potent immunomodulatory effects, significantly inhibiting poly(I:C)-induced expression of the proinflammatory genes TNFalpha, IL1B, IL6, and IL23A.	Poly I-C	156-165	interleukin 1 beta	Homo sapiens	224-228
33547278-2	2021	Despite being inert in human cells, UA in its soluble form (sUA) can increase the level of interleukin-1beta (IL-1beta) in murine macrophages.	Uric Acid	36-38	interleukin 1 beta	Homo sapiens	91-108
33673103-0	2021	Anandamide Influences Interleukin-1beta Synthesis and IL-1 System Gene Expressions in the Ovine Hypothalamus during Endo-Toxin-Induced Inflammation.	anandamide	0-10	interleukin 1 beta	Homo sapiens	22-39
33159583-5	2021	PM10-induced NICD signaling causes increased expression of interleukin-1 beta (IL-1beta) and enhances characteristics of cellular senescence, which leads to increased endothelial permeability in HBMECs.	pm10	0-4	interleukin 1 beta	Homo sapiens	59-77
33547534-10	2021	Moreover, nuclear staining for NF-kappaB and NF-kappaB target genes upregulation, IL1A and IL1B, were also observed after 5-Aza-2"-dC in normoxia.	Azacitidine	122-127	interleukin 1 beta	Homo sapiens	91-95
33456514-5	2021	Gene expression of chondroadherin, matrix metalloproteinase (MMP)-7, MMP-13 and MMP-19 was higher in the paracetamol-treated samples while gene expression of Cartilage Oligomeric Matrix Protein and interleukin-1beta was lower (P<0.05).	Acetaminophen	105-116	interleukin 1 beta	Homo sapiens	198-215
33239408-6	2021	Priming monocytes with LPS + sUA increased cytosolic pro-IL-1beta and mature IL-1beta and enhanced MSU crystal phagocytosis and its downstream IL-1beta expression (p<0.001).	sua	29-32	interleukin 1 beta	Homo sapiens	53-65
33239408-12	2021	Fingolimod phosphate activates PP2A in human monocytes and reduces cytosolic pro-IL-1beta content and its conversion to biologically active IL-1beta in human monocytes exposed to MSU crystals.	FTY 720P	0-20	interleukin 1 beta	Homo sapiens	77-89
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	interleukin 1 beta	Homo sapiens	261-279
33481676-4	2021	We have recently reported that in carcinoma Caco-2/pRS26 cells (shRNA for CFTR) or CF lung epithelial IB3-1 cells, the CFTR failure decreased mitochondrial Complex I activity due to an autocrine IL1B loop, and increased lactic acid production.	Lactic Acid	220-231	interleukin 1 beta	Homo sapiens	195-199
33441600-3	2021	We next demonstrated that KH176m selectively inhibited lipopolysaccharide (LPS) or interleukin-1beta (IL-1beta)-induced PGE2 production in control skin fibroblasts.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	26-31	interleukin 1 beta	Homo sapiens	83-100
33441600-3	2021	We next demonstrated that KH176m selectively inhibited lipopolysaccharide (LPS) or interleukin-1beta (IL-1beta)-induced PGE2 production in control skin fibroblasts.	Dinoprostone	120-124	interleukin 1 beta	Homo sapiens	83-100
33488575-5	2020	Ceftazidime inhibited integrin signaling via Syk, including inhibition of adhesion-dependent upregulation of interleukin-1beta and monocyte chemoattractant protein-1, but did not inhibit ITAM-dependent phosphorylation of Syk mediated by FcgammaRI signaling.	Ceftazidime	0-11	interleukin 1 beta	Homo sapiens	109-126
31023180-8	2021	A moderate negative correlation between melatonin and IL-1-beta in the group with PI (r = -0.3776, p = .0097), a closed negative correlation between the same indexes in the control group (r = -0.6785, p = .001), and a moderate negative correlation between melatonin and TNF-alpha (r = -0.4908, p = .02) were found.	Melatonin	40-49	interleukin 1 beta	Homo sapiens	54-63
33575345-0	2021	The Polymethoxy Flavonoid Sudachitin Inhibits Interleukin-1beta-Induced Inflammatory Mediator Production in Human Periodontal Ligament Cells.	polymethoxy flavonoid	4-25	interleukin 1 beta	Homo sapiens	46-63
33575345-0	2021	The Polymethoxy Flavonoid Sudachitin Inhibits Interleukin-1beta-Induced Inflammatory Mediator Production in Human Periodontal Ligament Cells.	sudachitin	26-36	interleukin 1 beta	Homo sapiens	46-63
33485352-9	2021	Baicalein significantly attenuated the inflammatory factors induced by LPS, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), matrix metalloprotein-1 (MMP-1), MMP-2 and monocyte chemoattractant protein 1 (MCP-1) at both mRNA and protein level.	baicalein	0-9	interleukin 1 beta	Homo sapiens	86-103
33148676-2	2021	By promoting TAM and MDSC infiltration, Interleukin-1 beta (IL-1b) may drive adaptive and innate immune resistance in renal cell carcinoma (RCC) and in other tumor types.	tam	13-16	interleukin 1 beta	Homo sapiens	40-58
33148676-2	2021	By promoting TAM and MDSC infiltration, Interleukin-1 beta (IL-1b) may drive adaptive and innate immune resistance in renal cell carcinoma (RCC) and in other tumor types.	tam	13-16	interleukin 1 beta	Homo sapiens	60-65
33148676-7	2021	Combination treatment with anti-IL-1b plus anti-PD-1 or cabozantinib showed increased anti-tumor activity that was associated with decreases in immunosuppressive MDSC and increases in M1-like TAM.	tam	192-195	interleukin 1 beta	Homo sapiens	32-37
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	nano-curcumin	13-26	interleukin 1 beta	Homo sapiens	261-279
33142636-5	2021	Three NPs greatly promoted the expression and secretion of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and interleukin-1beta (IL-1beta) in DC cells: C2,3,6 chitosan sulfate-HACC (C2,3,6-HACC; 200 kDa), C3,6 chitosan sulfate-HACC (C3,6-HACC; 200 kDa) and C6 chitosan sulfate-HACC (C6-HACC; 50 kDa).	c2,3,6 chitosan sulfate	162-185	interleukin 1 beta	Homo sapiens	120-137
32896640-8	2021	The levels of IL-1b, IL-18, and TSLP exhibited positive correlations with the AD severity index (Scoring AD index) and skin transepidermal water loss (TEWL), whereas an inverse correlation between IL-1a and Scoring AD index and IL-1a and TEWL was found.	Water	139-144	interleukin 1 beta	Homo sapiens	14-19
33470344-7	2021	Moreover, high glucose upregulated the protein expression of interleukin-1beta, ionized calcium-binding adapter molecule-1, NOD-like receptor family pyrin domain containing 3, cleaved caspase-1, and cleaved gasdermin D.	Glucose	15-22	interleukin 1 beta	Homo sapiens	61-78
30554535-7	2021	Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta).	gastrodin	0-9	interleukin 1 beta	Homo sapiens	264-281
30554535-7	2021	Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta).	gastrodin	0-9	interleukin 1 beta	Homo sapiens	283-291
33130474-8	2021	RESULTS: Celastrol significantly suppressed the cleavage of pro-caspase-1 and pro-IL-1beta, while not affecting the protein expressions of NLRP3, ASC, pro-caspase-1 and pro-IL-1beta in THP-1 cells, BMDMs and HEK293T cells.	celastrol	9-18	interleukin 1 beta	Homo sapiens	78-90
30638916-6	2021	The effect of GTG on the production of proinflammatory cytokines TNF-alpha and IL-1beta in monocytes were studied.	gtg	14-17	interleukin 1 beta	Homo sapiens	79-87
30638916-13	2021	There was significant downregulation of IL-1beta gene in LPS stimulated monocytes pretreated with GTG as compared to control.	gtg	98-101	interleukin 1 beta	Homo sapiens	40-48
33463129-5	2020	The effects of oridonin and doxorubicin on Gal-9, TIM-3, and interleukin-1beta (IL-1beta) gene expression were determined by real-time polymerase chain reaction (RT-PCR).	Doxorubicin	28-39	interleukin 1 beta	Homo sapiens	61-78
31324971-2	2021	Anti-IL1 agents are used in colchicine-resistant cases of FMF.	Colchicine	28-38	interleukin 1 beta	Homo sapiens	5-8
33157101-5	2020	At the molecular level, neferine could significantly alleviate the interleukin 1beta (IL-1beta)-induced mRNA and protein expression of intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1).	neferine	24-32	interleukin 1 beta	Homo sapiens	67-84
31649305-5	2020	More importantly, tyrosine kinase inhibitor treatment-induced L-MPs also induce human macrophages to release IL-1beta, leading to a tumor-promoting effect in a humanized mouse model.	Tyrosine	18-26	interleukin 1 beta	Homo sapiens	109-117
33324092-10	2020	Intraarticular injection of the IFX-loaded F127-HA-PGA hydrogel could alleviate the expression of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-17 (IL-17), in the synovial fluid and cartilage as well as relieve pain and inhibit cartilage destruction in RA.	f127-ha-pga	43-54	interleukin 1 beta	Homo sapiens	171-188
33007323-4	2020	In this study, lipopolysaccharides (LPS)-induced monocytes, lymphocytes, and monocyte-derived dendritic cells (MDDCs) as representative cells for both innate and adaptive immunity were treated with kefiran for 2 h. Kefiran had an anti-inflammatory effect on monocytes to reduce pro-inflammatory cytokines, interleukin 1 beta (IL-1beta) & tumor necrosis factor alpha (TNF-alpha), as well as nuclear factor kappa b (NF-kb).	kefir grain polysaccharide	198-205	interleukin 1 beta	Homo sapiens	306-324
33357720-5	2020	Additionally, TCDCA decreased tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, IL-8 and IL-12 through nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) activity.	Taurochenodeoxycholic Acid	14-19	interleukin 1 beta	Homo sapiens	72-89
33231794-2	2020	Immunocytochemical analysis and confocal microscopy showed that KE peptide reduces the synthesis of factors of the inflammatory response IL-1, NF-kappaB, and TGF-beta and stimulates the synthesis of sirtuin-6.	ke peptide	64-74	interleukin 1 beta	Homo sapiens	137-141
33012706-5	2020	Ensifentrine reduced the production of monocyte chemoattractant protein-1 and granulocyte monocyte colony-stimulating factor (GM-CSF) during challenge with interleukin-1beta Comparing the effect of ensifentrine with milrinone and roflumilast, selective PDE3 and PDE4 inhibitors, respectively, demonstrated that the anti-inflammatory effect of ensifentrine was mainly due to inhibition of PDE4.	ensifentrine	0-12	interleukin 1 beta	Homo sapiens	156-173
33038372-4	2020	KEY FINDINGS: Data indicated that high glucose increased the expression of interleukin-1beta (IL-1beta), an upstream regulator of nuclear factor-kappaB (NF-kappaB) pathway, through the nuclear localization of NF-kappaB.	Glucose	39-46	interleukin 1 beta	Homo sapiens	75-92
32976960-6	2020	RESULTS: Adipose tissue treated with BPA for 24 hours had reduced expression of the proinflammatory genes (IL6, IL1B, TNFA) and adipokines (ADIPOQ, FABP4).	bisphenol A	37-40	interleukin 1 beta	Homo sapiens	112-116
33263631-1	2020	OBJECTIVES: The present study was designed to explore the roles of inflammatory cytokines interleukin-1beta (IL-1beta) and Tumor growth factor-beta (TGF-beta) in the diagnosis and treatment of neonate bilirubin encephalopathy (BE).	Bilirubin	201-210	interleukin 1 beta	Homo sapiens	90-107
33244468-8	2020	Laquinimod significantly downregulated the expression of chemokines (monocyte chemotactic protein-1 and macrophage inflammatory protein-1), pro-inflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha), vascular endothelial growth factor, nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 and apoptosis-associated speck-like protein containing C-terminal caspase-recruitment domain adaptor protein in both injured corneas and RAW cells.	laquinimod	0-10	interleukin 1 beta	Homo sapiens	168-185
32975550-5	2020	When HUCPV were cultured with degradable Mg, a moderate inflammation (e.g., lower secretions of pro-inflammatory interleukin 1 beta and IL2, and tumour necrosis factor alpha, interferon gamma, anti-inflammatory interleukins 4, 5, 10, 13, and 1 receptor antagonists and granulocyte colony stimulating factor), and an increased pro-healing M2 macrophage phenotype were observed.	Magnesium	41-43	interleukin 1 beta	Homo sapiens	113-131
33045867-8	2020	Moreover, vitexin decreased expression of interleukin-1beta (IL-1beta), IL-17A and ROS in melanocytes induced by H2O2.	Hydrogen Peroxide	113-117	interleukin 1 beta	Homo sapiens	42-59
32975550-5	2020	When HUCPV were cultured with degradable Mg, a moderate inflammation (e.g., lower secretions of pro-inflammatory interleukin 1 beta and IL2, and tumour necrosis factor alpha, interferon gamma, anti-inflammatory interleukins 4, 5, 10, 13, and 1 receptor antagonists and granulocyte colony stimulating factor), and an increased pro-healing M2 macrophage phenotype were observed.	hucpv	5-10	interleukin 1 beta	Homo sapiens	113-131
32879146-0	2020	Sinomenine inhibited Interleukin-1beta-induced matrix metalloproteinases levels via SOCS3 up-regulation in SW1353 cells.	sinomenine	0-10	interleukin 1 beta	Homo sapiens	21-38
32879146-2	2020	Herein, the effect of sinomenine (SN) on Interleukin 1 beta (IL-1beta)-induced MMPs production and its underlying mechanism were explored in SW1353 cells.	sinomenine	22-32	interleukin 1 beta	Homo sapiens	41-59
32879146-2	2020	Herein, the effect of sinomenine (SN) on Interleukin 1 beta (IL-1beta)-induced MMPs production and its underlying mechanism were explored in SW1353 cells.	sinomenine	34-36	interleukin 1 beta	Homo sapiens	41-59
31774487-4	2020	METHODS AND RESULTS: Light-time mean serum melatonin concentration was lower in patients with PAH than in normal controls (11.06 +- 3.44 (7.13-15.6) vs. 14.55 +- 1.28 (8.0-19.4) pg/ml), which was negatively correlated with increased serum levels of interleukin-1beta (IL-1beta) in patients with PAH.	Melatonin	43-52	interleukin 1 beta	Homo sapiens	249-266
31774487-4	2020	METHODS AND RESULTS: Light-time mean serum melatonin concentration was lower in patients with PAH than in normal controls (11.06 +- 3.44 (7.13-15.6) vs. 14.55 +- 1.28 (8.0-19.4) pg/ml), which was negatively correlated with increased serum levels of interleukin-1beta (IL-1beta) in patients with PAH.	Melatonin	43-52	interleukin 1 beta	Homo sapiens	268-276
32866785-0	2020	Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1beta-stimulated human nucleus pulposus cells through activation of PI3K/Akt pathway.	4-hydroxyphenylethanol	25-32	interleukin 1 beta	Homo sapiens	120-137
32447799-8	2020	Increased proinflammatory markers (interleukin-1beta, tumor necrosis factor-alpha and nitric oxide overproduction) in GDM placentas were prevented by the EVOO-enriched diet (respectively P=0.001, P=0.001 and P=0.01 vs GDM).	evoo	154-158	interleukin 1 beta	Homo sapiens	35-52
32620467-5	2020	OBJECTIVE: The factors that can lead to RA includes inflammatory cascades, increased levels of (TNF-alpha) tumor necrosis factor alpha, IL-1b and IL-17 (interleukins) along with reduced levels of Nrf2 factors (nuclear factor-erythroid 2-related factor-2).	Radium	40-42	interleukin 1 beta	Homo sapiens	136-141
33144437-9	2020	Zinc chloride significantly up-regulated mitogen-activated protein kinase 12 (MAPK12) and down-regulated 6 related genes [baculoviral IAP repeat containing 3 (BIRC3), interleukin 1 beta (IL1B), proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1), prostaglandin-endoperoxide synthase 2 (PTGS2), PYD and CARD domain containing (PYCARD), and tumor necrosis factor (TNF)].	zinc chloride	0-13	interleukin 1 beta	Homo sapiens	167-185
33144437-9	2020	Zinc chloride significantly up-regulated mitogen-activated protein kinase 12 (MAPK12) and down-regulated 6 related genes [baculoviral IAP repeat containing 3 (BIRC3), interleukin 1 beta (IL1B), proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1), prostaglandin-endoperoxide synthase 2 (PTGS2), PYD and CARD domain containing (PYCARD), and tumor necrosis factor (TNF)].	zinc chloride	0-13	interleukin 1 beta	Homo sapiens	187-191
33161770-0	2020	Effects of miR-146a-5p on chondrocyte interleukin-1beta-induced inflammation and apoptosis involving thioredoxin interacting protein regulation.	mir-146a-5p	11-22	interleukin 1 beta	Homo sapiens	38-55
31710102-4	2020	Herein, we found that high-glucose (HG) treatment significantly induced cardiac inflammation, as manifested by increased proinflammatory cytokine production (IL-1beta) and NF-kappaB activity in CFs.	Glucose	27-34	interleukin 1 beta	Homo sapiens	158-166
33678310-6	2020	The nucleotide-binding oligomerization domain leucine-rich repeats and pyrin domain-containing protein 3 inflammasome plays a pivotal role in the inflammatory response to MSU crystals, and interleukin 1beta is the key cytokine mediating the inflammatory cascade.	Leucine	46-53	interleukin 1 beta	Homo sapiens	189-206
32394976-7	2020	In the spinal cord, the muscovite nanoparticle injections exhibited inhibitory effects on astrocyte and microglia activation and reduced the expression of pro-inflammatory cytokines, such as interleukin-1beta, tumor necrosis factor-alpha, interleiukin-6 and monocyte chemoattractant protein-1, which were upregulated in the partial sciatic nerve ligation model.	muscovite	24-33	interleukin 1 beta	Homo sapiens	191-208
32920000-6	2020	Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases.	Chloroquine	0-11	interleukin 1 beta	Homo sapiens	90-94
32920000-6	2020	Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases.	Hydroxychloroquine	12-30	interleukin 1 beta	Homo sapiens	90-94
32920000-6	2020	Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases.	Azithromycin	33-45	interleukin 1 beta	Homo sapiens	90-94
32920000-6	2020	Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases.	Chloroquine	19-30	interleukin 1 beta	Homo sapiens	90-94
33126239-6	2020	At high concentrations (100-200 mug/ml), GA also suppressed the production of Th17-differentiation cytokines (interleukin-1beta and interleukin-6) by lipopolysaccharide (LPS)-activated dendritic cells (DCs).	Glatiramer Acetate	41-43	interleukin 1 beta	Homo sapiens	110-127
33678310-6	2020	The nucleotide-binding oligomerization domain leucine-rich repeats and pyrin domain-containing protein 3 inflammasome plays a pivotal role in the inflammatory response to MSU crystals, and interleukin 1beta is the key cytokine mediating the inflammatory cascade.	Uric Acid	171-174	interleukin 1 beta	Homo sapiens	189-206
33023123-5	2020	EVOO supplementation was associated with a reduction in body weight, waist circumference, body mass index (BMI), alanine transaminase and FLI, as well as interleukin (IL)-6, IL-17A, tumor necrosis factor-alpha and IL-1B, while IL-10 increased.	evoo	0-4	interleukin 1 beta	Homo sapiens	214-219
33120759-7	2020	In further analysis, IL1B rs1143623 GG genotype had a higher level of total cholesterol (TCHO) and lower level of high density lipoprotein (HDL) in GDM patients compared with the CC/GC genotypes.	Cholesterol	76-87	interleukin 1 beta	Homo sapiens	21-25
33080990-2	2020	During surgery, ATP from damaged cells induces the release of interleukin-1beta, a potent pro-inflammatory cytokine that contributes to the development of postoperative systemic inflammation, sepsis and multi-organ damage.	Adenosine Triphosphate	16-19	interleukin 1 beta	Homo sapiens	62-79
33080990-3	2020	We recently demonstrated that C-reactive protein (CRP) inhibits the ATP-induced release of monocytic interleukin-1beta, although high CRP levels are deemed to be a poor prognostic marker.	Adenosine Triphosphate	68-71	interleukin 1 beta	Homo sapiens	101-118
33080990-8	2020	Accordingly, the inhibitory effect of CRP on the ATP-induced interleukin-1beta release was blunted in monocytes from coronary heart disease patients treated with atorvastatin compared to monocytes obtained before medication.	Adenosine Triphosphate	49-52	interleukin 1 beta	Homo sapiens	61-78
33080990-8	2020	Accordingly, the inhibitory effect of CRP on the ATP-induced interleukin-1beta release was blunted in monocytes from coronary heart disease patients treated with atorvastatin compared to monocytes obtained before medication.	Atorvastatin	162-174	interleukin 1 beta	Homo sapiens	61-78
32712091-7	2020	In addition, the expression of inflammatory factors, including interleukin-1beta (IL-lbeta), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) were decreased by 100 muM daidzein (73.8% +- 5.3%, 58.8 +- 9.0% and 55.5% +- 7.2%, respectively) in LPS-treated hepatocytes.	daidzein	184-192	interleukin 1 beta	Homo sapiens	63-80
33497945-3	2020	The results evidenced that Cd significantly increased the releases of interleukin-18 (IL-18) and interleukin-1beta (IL-1beta), lactate dehydrogenase (LDH) and nitric oxide (NO), relative conductivity and cellular reactive oxygen species (ROS) level.	Cadmium	27-29	interleukin 1 beta	Homo sapiens	97-114
33085641-10	2020	Among patients with known asbestos exposure, carriers of at least one polymorphic IL1B rs1143623 allele also had a lower risk of MM in multivariable analysis (OR = 0.50, 95% CI = 0.28-0.92, p = 0.025).	Asbestos	26-34	interleukin 1 beta	Homo sapiens	82-86
33117381-1	2020	The pro-inflammatory cytokine interleukin 1beta (IL-1beta) induces the synthesis of prostaglandin E2 by upregulating cyclooxygenase-2 (COX-2) in the synovial tissue of individuals with autoimmune diseases, such as rheumatoid arthritis (RA).	Dinoprostone	84-100	interleukin 1 beta	Homo sapiens	30-47
32941596-3	2020	Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) encompass a large number of innate immune sensors and receptors, which mediate the activation of Caspase-1 and the subsequent release of mature interleukin-1beta and interleukin-18.	Leucine	23-30	interleukin 1 beta	Homo sapiens	215-232
32415989-6	2020	In addition, we showed that 1,25-dihydroxyvitamin D3 inhibited genomic DNA fragment-induced TNFA and interleukin-1beta (IFNB) expression in human keratinocytes, and an intact function of cathelicidin anti-microbial peptide (CAMP) was required for this effect.	Calcitriol	28-52	interleukin 1 beta	Homo sapiens	101-118
32564679-4	2020	We found that viability and inflammatory factor release, including interleukin-1beta (IL-1beta) and IL-6, were negatively related to miR-375-3p expression in HaCaT cells.	mir-375-3p	133-143	interleukin 1 beta	Homo sapiens	67-84
31589306-7	2020	METHODS AND RESULTS: In vitro, we showed that 3-HAA reduces SREBP-2 expression and nuclear translocation, and apolipoprotein B secretion in HepG2 cell cultures, and inhibits inflammasome activation and IL-1beta production by macrophages.	3-Hydroxyanthranilic Acid	46-51	interleukin 1 beta	Homo sapiens	202-210
32851734-4	2020	LPA also induced expression of interleukin-1beta (IL-1beta) mRNA but no significant increase in IL-1beta protein was detected.	lysophosphatidic acid	0-3	interleukin 1 beta	Homo sapiens	31-48
32611559-4	2020	On this basis, colchicine interferes with several functions of leucocytes and the assembly and activation of the inflammasome as well, reducing the production of interleukin 1beta and interleukin 18.	Colchicine	15-25	interleukin 1 beta	Homo sapiens	162-179
32945585-6	2020	RESULTS: We verified that crystal-induced extracellular adenosine triphosphate (ATP) upregulation via the membrane purinergic 2X7 receptor (P2X7 R) promotes ROS generation and thereby activates NLRP3 inflammasome-mediated interleukin-1beta/18 maturation and gasdermin D cleavage.	Adenosine	56-65	interleukin 1 beta	Homo sapiens	222-239
32945585-6	2020	RESULTS: We verified that crystal-induced extracellular adenosine triphosphate (ATP) upregulation via the membrane purinergic 2X7 receptor (P2X7 R) promotes ROS generation and thereby activates NLRP3 inflammasome-mediated interleukin-1beta/18 maturation and gasdermin D cleavage.	Adenosine Triphosphate	80-83	interleukin 1 beta	Homo sapiens	222-239
33071750-7	2020	Moreover, ghrelin can upregulate the expression of neurotrophic factors such as brain-derived neurotrophic factor and modulate the release of proinflammatory cytokines such as tumor necrosis factor alpha and interleukin 1beta.	Ghrelin	10-17	interleukin 1 beta	Homo sapiens	208-225
32678677-7	2020	Mechanism of action of CGM-GLN combination was analyzed by measuring the levels of serum inflammatory markers interleukin 1 beta (IL-1beta), interleukin 6 (IL-6), and soluble vascular cell adhesion molecule-1 (sVCAM) at the baseline and 84th day.	cgm-gln	23-30	interleukin 1 beta	Homo sapiens	110-128
33124207-6	2020	Furthermore, HPDLCs under glucose-induced oxidative stress showed induction of inflammatory molecules (intercellular adhesion molecule-1, vascular cell adhesion protein-1, tumor necrosis factor-alpha, interleukin-1-beta) and disturbances of osteogenic differentiation (bone morphogenetic protein-2, and -7, runt-related transcription factor-2), cementogenesis (cementum protein-1), and autophagy-related molecules (autophagy related 5, light chain 3 I/II, beclin-1).	Glucose	26-33	interleukin 1 beta	Homo sapiens	201-219
32627113-7	2020	The BzATP and ATP induced calcium overload, mitochondria injury, interleukin-1beta (IL-1beta) secretion, and cytotoxicity can be inhibited by TRPA1 antagonists.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	4-9	interleukin 1 beta	Homo sapiens	65-82
32627113-7	2020	The BzATP and ATP induced calcium overload, mitochondria injury, interleukin-1beta (IL-1beta) secretion, and cytotoxicity can be inhibited by TRPA1 antagonists.	Adenosine Triphosphate	6-9	interleukin 1 beta	Homo sapiens	65-82
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	interleukin 1 beta	Homo sapiens	117-121
33062145-7	2020	The anti-inflammatory effect of SIRT3 underlying in oleanolic acid- (OLA-) prevented interleukin-1beta- (IL-1beta-) induced FLS dysfunction is then evaluated in vitro.	Oleanolic Acid	52-66	interleukin 1 beta	Homo sapiens	85-102
33062145-7	2020	The anti-inflammatory effect of SIRT3 underlying in oleanolic acid- (OLA-) prevented interleukin-1beta- (IL-1beta-) induced FLS dysfunction is then evaluated in vitro.	ola	69-72	interleukin 1 beta	Homo sapiens	85-102
33422158-7	2020	In RAW264.7 macrophages, the RMs inhibited the lipopolysaccharide-induced activation of p65/NF-kappaB, which in turn suppressed the transcription of its downstream inducible nitric oxide synthase, and cytokine genes such as interleukin-1beta and tumor necrosis factor-alpha .	Nitric Oxide	174-186	interleukin 1 beta	Homo sapiens	224-241
32391643-13	2020	SNP-SNP interaction of polymorphisms in IL-1B revealed the accumulated effect on osteoporosis risk.	snp-snp	0-7	interleukin 1 beta	Homo sapiens	40-45
32962126-1	2020	The bioactive piperine, a compound found in some pepper species, has been widely studied because of its therapeutic properties that include the inhibition of an important inflammation pathway triggered by interleukin-1 beta (IL-1beta).	piperine	14-22	interleukin 1 beta	Homo sapiens	205-223
32645333-5	2020	Both SAB and STS significantly inhibited LPS-induced inflammation in vitro, including down-regulated the protein expression levels of IL-1beta and TNF-alpha and the mRNA expression levels of IL1B and TNFA.	salvianolic acid B	5-8	interleukin 1 beta	Homo sapiens	191-195
32948212-0	2020	Resveratrol alleviates the interleukin-1beta-induced chondrocytes injury through the NF-kappaB signaling pathway.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	27-44
32948212-3	2020	The purpose of the experiment was to evaluate the protective role of RSV against the human OA chondrocyte injury induced by interleukin-1beta (IL-1beta).	Resveratrol	69-72	interleukin 1 beta	Homo sapiens	124-141
33029521-0	2020	Corrigendum to "Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1beta-Induced Inflammation and Apoptosis in Chondrocytes".	Hyaluronic Acid	77-92	interleukin 1 beta	Homo sapiens	126-143
33029521-0	2020	Corrigendum to "Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1beta-Induced Inflammation and Apoptosis in Chondrocytes".	Chitosan	93-101	interleukin 1 beta	Homo sapiens	126-143
32887644-5	2020	The effects of the PRMT5 inhibitor EPZ on interleukin-1beta-induced inflammation were examined in the chondrocytes of patients with OA and in the destabilized medial meniscus (DMM) of a mouse model of OA.	Uridine Diphosphate N-Acetylmuramic Acid	35-38	interleukin 1 beta	Homo sapiens	42-59
32924970-8	2020	Furthermore, DHC decreased the expression of pro-inflammatory cytokines induced by TNF-alpha, such as interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	dehydrocostus lactone	13-16	interleukin 1 beta	Homo sapiens	102-119
32983576-7	2020	Bafilomycin-A1 treatment significantly increased caspase-1 and Pro-IL-1beta expression in normal and MCD keratocytes.	bafilomycin	0-11	interleukin 1 beta	Homo sapiens	63-75
32983576-8	2020	Nod-like receptors pyrins-3 (NLRP3), caspase-1, Pro-IL-1beta, and IL-1beta levels were pronouncedly elevated in cells exposed to H2O2.	Hydrogen Peroxide	129-133	interleukin 1 beta	Homo sapiens	48-60
32899830-10	2020	It was revealed that ADE standardized to 25% of anthocyanins depresses the level of markers of inflammation and lipid peroxidation (Interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and malondialdehyde (MDA)) in in vitro conditions.	Adenine	21-24	interleukin 1 beta	Homo sapiens	132-150
32899830-10	2020	It was revealed that ADE standardized to 25% of anthocyanins depresses the level of markers of inflammation and lipid peroxidation (Interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and malondialdehyde (MDA)) in in vitro conditions.	Anthocyanins	48-60	interleukin 1 beta	Homo sapiens	132-150
31624866-6	2020	Phenolic acid extracts contained in 10 mg biofortified bread downregulated the LPS-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 as well as pro-inflammatory cytokines TNF-alpha and IL-1beta, in endothelial cells and monocytes, with CXCL-10 as the most reduced inflammatory mediator.	phenolic acid	0-13	interleukin 1 beta	Homo sapiens	194-202
32768946-4	2020	Inflammatory mediators, such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are highly upregulated in OA joints and induce ROS production and expression of matrix degrading proteases leading to cartilage extracellular matrix degradation and joint dysfunction.	Reactive Oxygen Species	174-177	interleukin 1 beta	Homo sapiens	32-49
31907823-8	2020	RESULTS: The results showed that AS-IV significantly reduced the levels of ROS, LDH, MDA, IL-8, IL-1beta, and IL-6, and increased the level of SOD in intermittent hypoxia-induced Beas-2B cells.	astragaloside A	33-38	interleukin 1 beta	Homo sapiens	96-104
32781843-6	2021	Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha).	dda	13-16	interleukin 1 beta	Homo sapiens	204-221
32841225-0	2020	Dioscin Attenuates Interleukin 1beta (IL-1beta)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-kappaB) Signaling in Human Nucleus Pulposus Cells.	dioscin	0-7	interleukin 1 beta	Homo sapiens	19-36
32911914-2	2020	Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors.	Oxygen	9-15	interleukin 1 beta	Homo sapiens	248-265
32911914-2	2020	Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors.	Adenosine	48-57	interleukin 1 beta	Homo sapiens	248-265
32911914-2	2020	Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors.	Uric Acid	75-84	interleukin 1 beta	Homo sapiens	248-265
32982316-3	2020	Objective: We hypothesized that 1,25(OH)2D3 opposes the TGF-beta1 or tumor necrosis factor alpha (TNF-alpha)-Interleukin 1 beta (IL-1beta) stimulation on airway fibroblast profibrogenic secretory phenotype observed in severe asthmatic patients.	(oh)2d3	36-43	interleukin 1 beta	Homo sapiens	109-127
32781843-6	2021	Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha).	diphtheria toxin fragment A	21-24	interleukin 1 beta	Homo sapiens	204-221
32460188-12	2020	The downstream genes of NF-kappaB, such as the pro-inflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta), were significantly downregulated by TMP pretreatment in the retina.	tetramethylpyrazine	206-209	interleukin 1 beta	Homo sapiens	140-157
32764386-5	2020	A diethylaminoethyl-dextran (DEAE-dex) functionalized superparamagnetic iron oxide nanoparticle (SPION) generated detectable quantities of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-10, the only tested material to do so.	DEAE-Dextran	2-27	interleukin 1 beta	Homo sapiens	179-196
32764386-5	2020	A diethylaminoethyl-dextran (DEAE-dex) functionalized superparamagnetic iron oxide nanoparticle (SPION) generated detectable quantities of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-10, the only tested material to do so.	DEAE-Dextran	29-37	interleukin 1 beta	Homo sapiens	179-196
32764386-5	2020	A diethylaminoethyl-dextran (DEAE-dex) functionalized superparamagnetic iron oxide nanoparticle (SPION) generated detectable quantities of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-10, the only tested material to do so.	ferric oxide	72-82	interleukin 1 beta	Homo sapiens	179-196
32809016-0	2020	Retraction: Resveratrol protects against apoptosis induced by interleukin-1beta in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3beta/caspase-3 pathway.	Resveratrol	12-23	interleukin 1 beta	Homo sapiens	62-79
32567290-2	2020	Therefore, the aim of this study was to determine the effect of vitamin A and D combination supplement on interleukin-1beta (IL-1beta) and clinical outcome in ischemic stroke.	Vitamin A	64-73	interleukin 1 beta	Homo sapiens	106-123
31902257-3	2020	Cortisol and IL-1beta are known to induce 11beta-HSD1 in number of tissues, but few results were obtained in ovarian GCs In this study, FF and GCs from PCOS and non-PCOS patients were collected to study the interaction of cortisol and IL-1beta in 11beta-HSD1 expression.	Hydrocortisone	0-8	interleukin 1 beta	Homo sapiens	235-243
31902257-6	2020	The induction of 11beta-HSD1 by IL-1beta was further inducted by cortisol, whereas the induction of IL-1beta and IL-6 expression by IL-1beta was completely inhibited by cortisol.	Hydrocortisone	65-73	interleukin 1 beta	Homo sapiens	32-40
31902257-6	2020	The induction of 11beta-HSD1 by IL-1beta was further inducted by cortisol, whereas the induction of IL-1beta and IL-6 expression by IL-1beta was completely inhibited by cortisol.	Hydrocortisone	169-177	interleukin 1 beta	Homo sapiens	100-108
31902257-6	2020	The induction of 11beta-HSD1 by IL-1beta was further inducted by cortisol, whereas the induction of IL-1beta and IL-6 expression by IL-1beta was completely inhibited by cortisol.	Hydrocortisone	169-177	interleukin 1 beta	Homo sapiens	100-108
31902257-7	2020	In conclusion, cortisol and IL-1beta preformed a synergistically upregulation of 11beta-HSD1 expression in GCs, contributing to the accumulation of cortisol in FF of PCOS patients.	Hydrocortisone	148-156	interleukin 1 beta	Homo sapiens	28-36
32450530-3	2020	Here, we investigated the effects of Imperatorin on interleukin-1beta (IL-1beta) induced expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in primary human OA chondrocytes and cartilage explants culture under pathological conditions and explored the associated signaling pathways.	Nitric Oxide	113-125	interleukin 1 beta	Homo sapiens	52-69
32626912-3	2020	Overexpression of miR-185-5p in NP cells markedly inhibited the enhanced extracellular matrix (ECM) catabolism induced by tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) treatment.	-185-5p	21-28	interleukin 1 beta	Homo sapiens	166-183
32227673-3	2020	Treatment with tomentosin (IC50  = 20 microM) significantly inhibited cell proliferation and oxidative stress-induced anti-cell proliferative (proliferating cell nuclear antigen and cyclin-D1) also regulated expression, drastically diminished tumor necrosis factor-alpha, nuclear factor-kappaB, interleukin-6, and interleukin-1beta expression levels, significantly upregulated Bcl-2 and Bax expression.	tomentosin	15-25	interleukin 1 beta	Homo sapiens	314-331
32567290-2	2020	Therefore, the aim of this study was to determine the effect of vitamin A and D combination supplement on interleukin-1beta (IL-1beta) and clinical outcome in ischemic stroke.	Deuterium	78-79	interleukin 1 beta	Homo sapiens	106-123
31945773-9	2020	This molecule is developmentally functional in immature but not mature intestinal enterocytes; ILA reduces the interleukin-8 (IL-8) response after IL-1beta stimulus.	indole-3-lactic acid	95-98	interleukin 1 beta	Homo sapiens	147-155
32449695-12	2020	ATP increased the expression of pro-inflammatory factors (e.g. IL1B; CCL7), as it is the case in HTPCs.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	63-67
32696949-0	2020	Resveratrol protects against apoptosis induced by interleukin-1beta in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3beta/caspase-3 pathway.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	50-67
31927051-8	2020	The result showed that nifedipine inhibited the expression of matrix metalloprotein(MMP)-13, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-2, inducible nitric oxide (NO) synthase (iNOS), and prostaglandin E2 (PGE2), as well as reduced ROS production in human OA chondrocytes, which was partially reversed by BR.	Nifedipine	23-33	interleukin 1 beta	Homo sapiens	93-115
32792990-6	2020	In subsequent dose response studies, medroxyprogesterone acetate, but not progesterone, at doses of 10-6-10-8 M inhibited interleukin-1beta induced interleukin-8 and matrix metalloproteinase 1 mRNA expression.	Medroxyprogesterone Acetate	37-64	interleukin 1 beta	Homo sapiens	122-139
32792990-6	2020	In subsequent dose response studies, medroxyprogesterone acetate, but not progesterone, at doses of 10-6-10-8 M inhibited interleukin-1beta induced interleukin-8 and matrix metalloproteinase 1 mRNA expression.	Progesterone	44-56	interleukin 1 beta	Homo sapiens	122-139
32792990-7	2020	We further demonstrated that inhibition of glucocorticoid receptor expression, but not progesterone receptor membrane component 1 knockdown with small interfering RNA transfection, resulted in a reversal in medroxyprogesterone acetate"s (10-7 M) inhibition of interleukin-1beta- induced matrix metalloproteinase 1 mRNA expression and interleukin-8 mRNA expression and protein expression.	Medroxyprogesterone Acetate	207-234	interleukin 1 beta	Homo sapiens	260-277
32694530-6	2020	IL1B expression decreased in CQ and CQ NP-treated cells after 48 h (p < 0.001) and 24 h (p < 0.05) of treatment, respectively.	Chloroquine	29-31	interleukin 1 beta	Homo sapiens	0-4
32694530-6	2020	IL1B expression decreased in CQ and CQ NP-treated cells after 48 h (p < 0.001) and 24 h (p < 0.05) of treatment, respectively.	Chloroquine	36-38	interleukin 1 beta	Homo sapiens	0-4
32068949-0	2020	Cytolethal distending toxin-induced release of interleukin-1beta by human macrophages is dependent upon activation of glycogen synthase kinase (GSK) 3beta, spleen tyrosine kinase (Syk) and the noncanonical inflammasome.	Tyrosine	163-171	interleukin 1 beta	Homo sapiens	47-64
31923551-9	2020	By Week 8, responders showed a downtrend in IL-1beta compared to non-responders in the ESC+CBX treatment arm.	Citalopram	87-90	interleukin 1 beta	Homo sapiens	44-52
32764923-8	2020	CoQ10-loaded nano-emulsions showed also strong anti-inflammatory effects reducing leukotriene B4 and p65/NF-kappaB expression and Interleukin 1beta and 6 production during anticancer treatments.	coenzyme Q10	0-5	interleukin 1 beta	Homo sapiens	130-153
32630207-7	2020	ATRA alone induces NLRP3 expression, and enhances LPS-induced expression of NLRP3 and pro-IL-1beta via the regulation of signal transduction pathways, like NF-kappaB, p38, and ERK.	Tretinoin	0-4	interleukin 1 beta	Homo sapiens	86-98
32361974-3	2020	The results showed that endosulfan could induce inflammatory response and dysfunction by increasing the release of inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inducing ROS production in HUVECs.	Endosulfan	24-34	interleukin 1 beta	Homo sapiens	146-163
32629886-6	2020	Interestingly, the secretion of interleukin-1 beta (IL-1beta) was only modestly impacted by NaHS exposure despite a significant accumulation of IL-1beta pro-form.	sodium bisulfide	92-96	interleukin 1 beta	Homo sapiens	32-50
32171072-0	2020	Anorexic responses to trichothecene deoxynivalenol and its congeners correspond to secretion of tumor necrosis factor-alpha and interleukin-1beta.	trichothecene deoxynivalenol	22-50	interleukin 1 beta	Homo sapiens	128-145
31693761-0	2020	Iron Potentiates Microglial Interleukin-1beta Secretion Induced by Amyloid-beta.	Iron	0-4	interleukin 1 beta	Homo sapiens	28-45
31693761-10	2020	Potentiation of Abeta-elicited IL-1beta induction by iron was also antagonized by ROS inhibitors, supporting the model that DMT1-mediated iron loading and subsequent increase in ROS contribute to the inflammatory effects of Abeta in microglia.	Iron	53-57	interleukin 1 beta	Homo sapiens	31-39
31693761-10	2020	Potentiation of Abeta-elicited IL-1beta induction by iron was also antagonized by ROS inhibitors, supporting the model that DMT1-mediated iron loading and subsequent increase in ROS contribute to the inflammatory effects of Abeta in microglia.	Iron	138-142	interleukin 1 beta	Homo sapiens	31-39
31693761-11	2020	Immunoblotting and immunofluorescence microscopy indicate that iron enhances Abeta activation of NF-kappaB signaling to promote IL-1beta synthesis.	Iron	63-67	interleukin 1 beta	Homo sapiens	128-136
31693761-13	2020	Most importantly, iron appears to exacerbate the pro-inflammatory effects of Abeta to increase IL-1beta levels.	Iron	18-22	interleukin 1 beta	Homo sapiens	95-103
32321163-6	2020	Correspondingly, pro-Il-1b and S100a8 gene expression increased along with extracellular ATP in the skin.	Adenosine Triphosphate	89-92	interleukin 1 beta	Homo sapiens	21-26
32452426-0	2020	Glibenclamide alters interleukin-8 and interleukin-1beta of primary human monocytes from diabetes patients against Mycobacterium tuberculosis infection.	Glyburide	0-13	interleukin 1 beta	Homo sapiens	39-56
32536965-14	2020	Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2).	kaempferol	107-117	interleukin 1 beta	Homo sapiens	215-219
32602358-0	2021	Glycyrrhizin, an HMGB1 inhibitor, Suppresses Interleukin-1beta-Induced Inflammatory Responses in Chondrocytes from Patients with Osteoarthritis.	Glycyrrhizic Acid	0-12	interleukin 1 beta	Homo sapiens	45-62
31958219-10	2020	CONCLUSION: As a result of the study the relationship of the alleles/genotypes of the IL1B rs16944, IL10 rs1800872, CTLA4 rs3087243, NFKB1 rs28362491 polymorphic loci and the TNFA rs1800629*A - LTA rs909253*G haplotype with the methotrexate efficacy in JIA was established (taking into account the differences by sex).	Methotrexate	228-240	interleukin 1 beta	Homo sapiens	86-90
32569211-4	2020	Meanwhile, MIR103 and MIR107 were negatively correlated with acute pathologic and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, serum creatinine, C-reactive protein, tumor necrosis factor, interleukin 1beta, interleukin 6 and interleukin 8, while positively correlated with albumin in sepsis patients.	mir103	11-17	interleukin 1 beta	Homo sapiens	238-255
32647537-11	2020	Conclusion: Diclofenac, which has been shown to have active transport into the central nervous system, and which has been shown to lower amyloid beta and interleukin 1 beta, is associated with a significantly lower frequency of AD compared with etodolac and naproxen.	Diclofenac	12-22	interleukin 1 beta	Homo sapiens	154-172
31504417-1	2020	AIMS: The Canakinumab Antiinflammatory Thrombosis Outcomes Study (CANTOS) established that targeting inflammation with interleukin-1beta (IL-1beta) inhibition can significantly reduce cardiovascular (CV) event rates in the absence of any beneficial effects on cholesterol.	Cholesterol	260-271	interleukin 1 beta	Homo sapiens	119-136
31504417-1	2020	AIMS: The Canakinumab Antiinflammatory Thrombosis Outcomes Study (CANTOS) established that targeting inflammation with interleukin-1beta (IL-1beta) inhibition can significantly reduce cardiovascular (CV) event rates in the absence of any beneficial effects on cholesterol.	Cholesterol	260-271	interleukin 1 beta	Homo sapiens	138-146
32536965-14	2020	Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2).	Quercetin	119-128	interleukin 1 beta	Homo sapiens	215-219
32536965-14	2020	Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2).	7-methoxy-2-methyl isoflavone	130-159	interleukin 1 beta	Homo sapiens	215-219
32536965-14	2020	Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2).	naringenin	161-171	interleukin 1 beta	Homo sapiens	215-219
32173427-9	2020	In addition to differentially reducing IL6 and IL8 expression, both IN and tryptanthrin also potently decreased the expression of anti-microbial S100A9 peptide, CCL20 chemokine, IL1B and TNFA cytokines, independent of NF-kappaB-p65-activation.	tryptanthrine	75-87	interleukin 1 beta	Homo sapiens	178-182
32536965-14	2020	Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2).	formononetin	173-185	interleukin 1 beta	Homo sapiens	215-219
31365924-8	2020	Patients treated with beta-lactam had higher IL-1beta on day 3 (median +5.6 pg/mL; P=0.007) and day 7 (+10.9 pg/ml; P=0.016).	beta-Lactams	22-33	interleukin 1 beta	Homo sapiens	45-53
32595496-5	2020	SB216763 and Nec-1 also decreased levels of inflammatory related cytokines, including interleukin-6 (IL-6), interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha).	SB 216763	0-8	interleukin 1 beta	Homo sapiens	108-126
31365924-9	2020	Ex vivo, the addition of IL-1 receptor antagonist anakinra to whole blood reduced staphylococcal killing, supporting a functional significance of the host IL-1beta response in SaB clearance.	sab	176-179	interleukin 1 beta	Homo sapiens	155-163
32321279-8	2020	Transfection of miR-887-3p into HPMECs altered gene expression, including the upregulation of several genes previously associated with ARDS (e.g., CXCL10, CCL5, CX3CL1, VCAM1, CASP1, IL1B, IFNB, and TLR2), and activation of cellular pathways relevant to the response to infection.	mir-887-3p	16-26	interleukin 1 beta	Homo sapiens	183-187
32526964-7	2020	The BaP-induced IL1A and IL1B was also downregulated by BAI.	Benzo(a)pyrene	4-7	interleukin 1 beta	Homo sapiens	25-29
31822346-13	2020	CONCLUSION: UPM induces the expression of IL-6, CXCL1, IL-1beta, and TNF-alpha in nasal fibroblasts and this effect is reversed by FP via the STAT3 and NF-kappaB signalling pathways.	fp	131-133	interleukin 1 beta	Homo sapiens	55-63
32259365-3	2020	We demonstrated that M2 macrophages produce interleukin 1beta (IL-1beta), which activates phosphorylation of the glycolytic enzyme glycerol-3-phosphate dehydrogenase (GPD2) at threonine 10 (GPD2 pT10) through phosphatidylinositol-3-kinase-mediated activation of protein kinase-delta (PKCdelta) in glioma cells.	Threonine	176-185	interleukin 1 beta	Homo sapiens	44-61
32615723-0	2020	Gemigliptin Inhibits Interleukin-1beta-Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway.	LC15-0444	0-11	interleukin 1 beta	Homo sapiens	21-38
32199215-3	2020	Our study showed that treating human bronchial epithelial (16HBE) cells with neodymium oxide caused an inflammatory response by upregulating the expression of interleukin-8 (IL-8) and interleukin-1 beta (IL-1beta).	neodymium oxide	77-92	interleukin 1 beta	Homo sapiens	184-202
32615723-3	2020	We investigated inhibition of interleukin-1beta (IL-1beta)-induced EndMT by gemigliptin, a dipeptidyl peptidase-IV inhibitor.	LC15-0444	76-87	interleukin 1 beta	Homo sapiens	30-47
32249647-7	2020	Consistently, laquinimod prevented MPP+-induced secretions of interleukin 1beta (IL-1beta) and interleukin-18 (IL-18).	laquinimod	14-24	interleukin 1 beta	Homo sapiens	62-79
32249647-7	2020	Consistently, laquinimod prevented MPP+-induced secretions of interleukin 1beta (IL-1beta) and interleukin-18 (IL-18).	mangion-purified polysaccharide (Candida albicans)	35-39	interleukin 1 beta	Homo sapiens	62-79
32172204-6	2020	Melatonin-treated HUVECs showed a decrease of pro-inflammatory mRNAs [interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha)] under the stimulation of SLE medium.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	70-87
31609478-8	2020	Gene expression analysis in PDAC tumors (n = 63) showed a positive correlation between the expression of NOS2 and the tryptophan/kynurenine pathway genes, including indoleamine-2,3-dioxygenase 1 (IDO1) and several aryl hydrocarbon receptor (AHR)-target genes including NFE2L2 (NRF2), SERPINB2, IL1b, IL6 and IL8, which are implicated in pancreatic cancer.	Kynurenine	129-139	interleukin 1 beta	Homo sapiens	294-298
32456215-4	2020	Here, we report a novel finding that PRMT5 is phosphorylated on serine 15 (S15) in response to interleukin-1beta (IL-1beta) stimulation.	Serine	64-70	interleukin 1 beta	Homo sapiens	95-112
32801436-8	2020	Inflammatory cytokine MCP-1 was remarkably decreased in both study groups but (heat shock protein 60 (HSP60), MCP-1 and interleukin-1beta (IL-1beta)) significantly decreased levels were observed among the TMZ-EECP group (P<0.05).	Trimetazidine	205-208	interleukin 1 beta	Homo sapiens	120-137
32251722-4	2020	In addition to the effect as a carbonic anhydrase inhibitor, methazolamide directly activates the transcription factor anti-oxidative nuclear factor-related factor 2 (Nrf2) and inhibits interleukin-1beta (IL-1beta) release.	Methazolamide	61-74	interleukin 1 beta	Homo sapiens	186-203
32333497-0	2020	Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1beta.	lysophosphatidic acid	0-21	interleukin 1 beta	Homo sapiens	113-130
32333497-6	2020	We also observed an indirect effect of lysophosphatidic acid on corneal endothelial cell proliferation mediated by the stimulation of interleukin-1beta secretion from stromal cells.	lysophosphatidic acid	39-60	interleukin 1 beta	Homo sapiens	134-151
31802418-12	2020	Treatment with RK-33 inhibits the Tat and cocaine-dependent increase in the number and size of microglia and the proinflammatory cytokines IL-6, TNF-alpha, MCP-1/CCL2, MIP-2, IL-1alpha and IL-1beta.	Cocaine	42-49	interleukin 1 beta	Homo sapiens	189-197
31019266-3	2020	Findings suggest that serum concentrations of high-sensitivity C-reactive protein (hsCRP), z-inflammation composite score [ICS, combining elevated hsCRP and ESR with low serum albumin and iron], and serum interleukin (IL) 1beta were positively associated with DeltaCES-Dtotal (Delta: annual rate of increase) among Whites only.	deltaces-dtotal	260-275	interleukin 1 beta	Homo sapiens	205-227
31833613-8	2020	Diosmetin treatment resulted in an increase in apoptotic rates and a reduction in TNF-alpha-induced production of IL-1beta, IL-6, IL-8, and MMP-1 in MH7A cells.	diosmetin	0-9	interleukin 1 beta	Homo sapiens	114-122
32423023-1	2020	The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and activates caspase-1, which provokes release of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18 as well as pyroptosis to engage in innate immune defense.	Leucine	38-45	interleukin 1 beta	Homo sapiens	306-323
32223187-6	2020	In addition, silica increased the expression of interleukin 1 beta (IL-1beta), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), and T3 treatment reduced those pro-inflammatory cytokines secretion.	Silicon Dioxide	13-19	interleukin 1 beta	Homo sapiens	48-66
32365105-9	2020	Progesterone partially blocked thrombin-induced myometrial contractions, which was accompanied by suppression of the thrombin-induced increase of PTGS2 and IL1B mRNA expressions as well as suppression of PAR1 expression.	Progesterone	0-12	interleukin 1 beta	Homo sapiens	156-160
31473895-9	2020	There was a decrease in concentration of IL-1beta and TNF-alpha (P &lt; 0.05) with an increasing extracellular concentration of Cu and Fe.	Copper	128-130	interleukin 1 beta	Homo sapiens	41-49
31473895-9	2020	There was a decrease in concentration of IL-1beta and TNF-alpha (P &lt; 0.05) with an increasing extracellular concentration of Cu and Fe.	Iron	135-137	interleukin 1 beta	Homo sapiens	41-49
31714001-4	2020	Since glyburide (a specific inhibitor of K+ efflux channels) inhibited the transcription of NLRP3, IL-1beta, and IL-18, the role of K+ efflux in the activation of inflammasomes in APOL1 risk milieu was implicated.	Glyburide	6-15	interleukin 1 beta	Homo sapiens	99-107
31943712-5	2020	The results showed that nickel could induce cell apoptosis, increase oxidative stress, and promote the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, C-reaction protein.	Nickel	24-30	interleukin 1 beta	Homo sapiens	184-206
32282893-6	2020	Functional experiments at baseline measuring apoptosis-associated speck-like protein containing a CARD (ASC) speck formation showed that the NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome was overactive in monocytes from patients with primary progressive multiple sclerosis, and canonical NLRP3 inflammasome activation with a combination of ATP plus lipopolysaccharide was associated with increased IL1B production in this group of patients.	Leucine	145-152	interleukin 1 beta	Homo sapiens	428-432
33076703-8	2020	Glucagon receptor was expressed in THP-1 cells, and 1 nM glucagon decreased the ratio of interleukin-1beta to interleukin-10 gene expression, which was significantly prevented by L-168049.	L 168049	179-187	interleukin 1 beta	Homo sapiens	89-106
31787396-6	2020	The pretreatments of HT-29 cells with EGCg, RBA and EGCg-RBA significantly repressed the transcriptional activation of mitogen-activated protein kinase 14, nuclear transcription factor-kappaB, and activators of transcription 3 as stimulated with interleukin-1beta afterwards, leading to attenuated expressions of corresponding downstream genes.	epigallocatechin gallate	38-42	interleukin 1 beta	Homo sapiens	246-263
31787396-6	2020	The pretreatments of HT-29 cells with EGCg, RBA and EGCg-RBA significantly repressed the transcriptional activation of mitogen-activated protein kinase 14, nuclear transcription factor-kappaB, and activators of transcription 3 as stimulated with interleukin-1beta afterwards, leading to attenuated expressions of corresponding downstream genes.	epigallocatechin gallate	52-56	interleukin 1 beta	Homo sapiens	246-263
32020710-5	2020	Our results indicated that paroxetine attenuates proinflammatory cytokine production (interleukin-1beta [IL-1beta], IL-17, and tumor necrosis factor-alpha) and increases expression of IL-10 and JAK2/STAT3 evidence for macrophages polarization to M2 subset and functional dendritic cells depletion.	Paroxetine	27-37	interleukin 1 beta	Homo sapiens	86-103
31774188-2	2020	4-MU also blocked safranin O loss from human cartilage explants exposed to IL1beta in vitro.	Hymecromone	0-4	interleukin 1 beta	Homo sapiens	75-82
32028542-0	2020	Oleanolic acid mitigates interleukin-1beta-induced chondrocyte dysfunction by regulating miR-148-3p-modulated FGF2 expression.	Oleanolic Acid	0-14	interleukin 1 beta	Homo sapiens	25-42
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	81-95	interleukin 1 beta	Homo sapiens	112-129
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	97-100	interleukin 1 beta	Homo sapiens	112-129
31774188-2	2020	4-MU also blocked safranin O loss from human cartilage explants exposed to IL1beta in vitro.	safranine T	18-28	interleukin 1 beta	Homo sapiens	75-82
32375462-1	2020	OBJECTIVE: The association between preterm birth (PTB), Spindle and Kinetochore Associated Complex Subunit 2 gene (SKA2), cortisol and anxiety have been shown, but in this study, we aimed to clarify whether the expression of the SKA2 gene plays a role in interleukin1beta (IL-1beta) level since increasing level of IL-1beta is linked with PTB.	Hydrocortisone	122-130	interleukin 1 beta	Homo sapiens	255-271
31471894-9	2020	Compared with HGECs in normal culture medium, ATP6V0C expression and LC3-II/I expression ratio were significantly down-regulated, with an up-regulated expression of P62, IL1beta in HGECs under high glucose condition.	Glucose	198-205	interleukin 1 beta	Homo sapiens	170-177
31471894-10	2020	Over-expression of ATP6V0C rescued high glucose induced disruption of ALP in HBLV-h-ATP6V0C transfected HGECs, with significantly up-regulation of LC3-II/I and down-regulation of P62, IL1beta.	Glucose	40-47	interleukin 1 beta	Homo sapiens	184-191
31796217-8	2020	Interleukin 1beta, monocyte chemoattractant protein 1, and IL-6 messenger RNA expression were considerably downregulated in the small intestine of the GAL group.	galactomannan	151-154	interleukin 1 beta	Homo sapiens	0-17
32410860-0	2020	Carbon Monoxide-Releasing Molecule-3 Suppresses Tumor Necrosis Factor-alpha- and Interleukin-1beta-Induced Expression of Junctional Molecules on Human Gingival Fibroblasts via the Heme Oxygenase-1 Pathway.	Carbon Monoxide	0-15	interleukin 1 beta	Homo sapiens	81-98
32349389-0	2020	Anti-osteoarthritic Effects of an Herbal Composition LI73014F2 on Interleukin-1beta-induced Primary Human Articular Chondrocytes.	li73014f2	53-62	interleukin 1 beta	Homo sapiens	66-83
31950542-3	2020	Pre-exposure of 1.5% isoflurane for 0.5 h induced anti-inflammatory effects (measured by cytokine production of TNF-alpha, IL-8, and IL-1beta) in both human THP-1 cells and primary human peripheral blood monocytes stimulated by lipopolysaccharide.	Isoflurane	21-31	interleukin 1 beta	Homo sapiens	133-141
32550560-0	2020	Glucose and TNF enhance expression of TNF and IL1B, and histone H3 acetylation and K4/K36 methylation, in juvenile macrophage cells.	Glucose	0-7	interleukin 1 beta	Homo sapiens	46-50
32550560-2	2020	In this study, we investigated whether high glucose and/or tumor necrosis factor (TNF) would enhance pro-inflammatory cytokine expression of tumor necrosis factor (TNF) and interleukin (IL)-1beta (IL1B) by altering histone modifications in U937, a juvenile macrophage cell line.	Glucose	44-51	interleukin 1 beta	Homo sapiens	197-201
32550560-3	2020	The mRNA levels of TNF and IL1B in U937 cells were significantly affected by glucose concentration and TNF treatment.	Glucose	77-84	interleukin 1 beta	Homo sapiens	27-31
32550560-4	2020	Mono-methylated histone H3K4 signals around TNF and IL1B were lower in cells treated with high glucose compared with low glucose.	Glucose	95-102	interleukin 1 beta	Homo sapiens	52-56
32550560-4	2020	Mono-methylated histone H3K4 signals around TNF and IL1B were lower in cells treated with high glucose compared with low glucose.	Glucose	121-128	interleukin 1 beta	Homo sapiens	52-56
32550560-6	2020	TNF treatment of U937 cells cultured in high glucose enhanced histone H3K36 tri-methylation, particularly around the gene regions of TNF and IL1B.	Glucose	45-52	interleukin 1 beta	Homo sapiens	141-145
32550560-8	2020	The induction of acetylation and tri-methylation of K4 and K36 of histone H3 around TNF and IL1B by treatment with high glucose and/or TNF was positively associated with the induction of these genes in juvenile macrophage U937 cells.	Glucose	120-127	interleukin 1 beta	Homo sapiens	92-96
32316988-5	2020	RESULTS: Exposure to both Si10 and Min-U-Sil induced gene expression and release of CXCL8, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1alpha (IL-1alpha) and interleukin-1beta (IL-1beta) in a concentration-dependent manner.	si10	26-30	interleukin 1 beta	Homo sapiens	189-206
32008742-5	2020	Consistent with this, treatment with MLN4924, a Cullin-neddylation inhibitor that suppresses SCF E3 activity, increased Lipin-2 protein and concomitantly decreased Il1b expression.	pevonedistat	37-44	interleukin 1 beta	Homo sapiens	164-168
31981945-10	2020	Furthermore, the treatment distinctly inhibited tGCI-induced microglia activation and significantly reduced levels of pro-inflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha).	tgci	48-52	interleukin 1 beta	Homo sapiens	146-163
32001222-6	2020	EGCG priming alleviated the detrimental effects of thermal stress in hWJMSCs as observed by significant down-regulation in expression of BCL2 associated X (BAX), interleukin 6 (IL6), and interleukin 1 beta (IL1beta) genes, while proliferating cell nuclear antigen (PCNA), BCL2 like 1 (BCL2L1), vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGFbeta1), hepatocyte growth factor (HGF) and interleukin 4 (IL4) genes were up-regulated.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	187-205
31876323-7	2020	Cilengitide suppressed the gene expression of IL-1beta, TNF-alpha, MMP-3 and MMP-13 induced by excessive mechanical stress.	Cilengitide	0-11	interleukin 1 beta	Homo sapiens	46-54
31876323-8	2020	In addition, protein expression of IL1-beta and MMP-13 were also inhibited by the addition of cilengitide.	Cilengitide	94-105	interleukin 1 beta	Homo sapiens	35-43
31476928-2	2020	The aim of this study was to investigate the effect of blood glucose levels on DNA methylation of IL-1beta and IL1R1 genes in the peripheral blood mononuclear cells (PBMCs) of non-diabetic, type 2 pre-diabetic and diabetic individuals.	Glucose	61-68	interleukin 1 beta	Homo sapiens	98-106
31476928-8	2020	Conclusion: We propose that the DNA methylation status of the CpG sites cg18773937 and cg23149881 in IL-1beta gene and the CpG site cg13399261 in IL1R1 gene could serve as an epigenetic marker of chronic inflammation and T2D development.	cg18773937	72-82	interleukin 1 beta	Homo sapiens	101-109
32076940-7	2020	Meanwhile, SAL also alleviated the pyroptosis, as evidenced by inhibiting caspase-1 activation, interleukin-1beta (IL-1beta) release, and TUNEL-positive staining, and decreasing the expression of Gasdermin D (GSDMD).	rhodioloside	11-14	interleukin 1 beta	Homo sapiens	96-113
32062078-4	2020	We demonstrated recently that AAT inhibits the ATP-induced release of the pro-inflammatory cytokine interleukin-1beta by human monocytes by a mechanism involving activation of metabotropic functions at nicotinic acetylcholine receptors.	Adenosine Triphosphate	47-50	interleukin 1 beta	Homo sapiens	100-117
32062078-4	2020	We demonstrated recently that AAT inhibits the ATP-induced release of the pro-inflammatory cytokine interleukin-1beta by human monocytes by a mechanism involving activation of metabotropic functions at nicotinic acetylcholine receptors.	Acetylcholine	212-225	interleukin 1 beta	Homo sapiens	100-117
31838663-8	2020	Tacrolimus significantly inhibited TNF-alpha/IL-17A-induced IL-36gamma, CCL-20, IL-1beta, and S100-A9 expression at gene level and IL-36gamma and CCL-20 expression at protein level.	Tacrolimus	0-10	interleukin 1 beta	Homo sapiens	80-88
31903636-7	2020	RESULTS: MiR-142-5p was downregulated in IL-1beta-treated chondrocytes while SGTB and XIST levels were increased.	2-chloro-1,1-difluoroethane	9-19	interleukin 1 beta	Homo sapiens	41-49
32062078-11	2020	The capacity of patient AAT to inhibit the ATP-induced release of interleukin-1beta might be slightly reduced in response to heart surgery and complex formation of patient AAT with neutrophil elastase was unimpaired.	Adenosine Triphosphate	43-46	interleukin 1 beta	Homo sapiens	66-83
31587475-6	2020	SA similarly increased inflammatory reactions by increasing the level of interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta.	sodium arsenite	0-2	interleukin 1 beta	Homo sapiens	121-138
31926875-4	2020	Furthermore, reactive oxygen species have been found to play a crucial role among pathogenesis of TB infection in diabetics (DM-TB) through regulating inflammasome activation and the production of IL-1beta, which in turn modulates the inflammatory network in TB infection, leading to dysfunctional inflammatory responses and tissue remodeling.	Oxygen	22-28	interleukin 1 beta	Homo sapiens	197-205
31898158-4	2020	We hypothesized that exercise releases ATP to activate P2X4 receptors on muscle macrophages, which subsequently release interleukin-1beta (IL-1beta) to produce hyperalgesia.	Adenosine Triphosphate	39-42	interleukin 1 beta	Homo sapiens	120-137
32176389-2	2020	This study aimed to investigate the effect of 17beta-estradiol (E2) on the inflammatory response stimulated by interleukin-1 beta (IL-1beta) in human oral mucosal epithelial cells (hOMECs) and its possible mechanism.	Estradiol	46-62	interleukin 1 beta	Homo sapiens	111-129
31898158-4	2020	We hypothesized that exercise releases ATP to activate P2X4 receptors on muscle macrophages, which subsequently release interleukin-1beta (IL-1beta) to produce hyperalgesia.	Adenosine Triphosphate	39-42	interleukin 1 beta	Homo sapiens	139-147
31898158-7	2020	We further show that macrophages primed with LPS differentially released IL-1beta when treated with ATP in neutral or acidic pH.	Adenosine Triphosphate	100-103	interleukin 1 beta	Homo sapiens	73-81
32218354-5	2020	Vildagliptin is able to limit inflammation by suppression of the NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway and proinflammatory agents such as TNF-alpha (tumor necrosis factor alpha), IL-1beta (Interleukin-1beta), and IL-8 (Interleukin 8).	Vildagliptin	0-12	interleukin 1 beta	Homo sapiens	244-261
32234475-5	2020	Dectin-1 also promotes inflammasome-dependent interleukin-1beta (IL-1beta) secretion through leukotriene B4 production.	Leukotriene B4	93-107	interleukin 1 beta	Homo sapiens	46-63
31846839-11	2020	Animal experiments consistently demonstrated that Vinp treatment significantly attenuated ovariectomy-induced bone loss with a decrease in the osteoclast number and decreases in serum levels of RANKL, TRAP, interleukin-1beta, and tumor necrosis factor-alpha, as well as increased serum levels of osteoprotegerin.	vinpocetine	50-54	interleukin 1 beta	Homo sapiens	207-224
32057231-3	2020	The ultrasmall-size (<10 nm) Au nanoparticles preferentially activate the NLRP3 inflammasome for Caspase-1 maturation and interleukin-1beta production, while the larger-size Au nanoparticles (>10 nm) trigger the NF-kappaB signaling pathway.	Gold	29-31	interleukin 1 beta	Homo sapiens	122-139
32214022-1	2020	The aim of this study was to assess the influence of lead (Pb) at low concentrations (imitating Pb levels in human blood in chronic environmental exposure to this metal) on interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) concentrations and the activity and expression of COX-1 and COX-2 in THP-1 macrophages.	Lead	59-61	interleukin 1 beta	Homo sapiens	173-190
32214022-1	2020	The aim of this study was to assess the influence of lead (Pb) at low concentrations (imitating Pb levels in human blood in chronic environmental exposure to this metal) on interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) concentrations and the activity and expression of COX-1 and COX-2 in THP-1 macrophages.	Metals	163-168	interleukin 1 beta	Homo sapiens	173-190
32041779-4	2020	PolyP up-regulated LPS-induced production of the inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1beta, and interleukin-6, in macrophages, and the effect was polyP dose- and chain length-dependent.	poly If	0-5	interleukin 1 beta	Homo sapiens	110-127
32041779-4	2020	PolyP up-regulated LPS-induced production of the inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1beta, and interleukin-6, in macrophages, and the effect was polyP dose- and chain length-dependent.	Polyphosphates	183-188	interleukin 1 beta	Homo sapiens	110-127
32194991-5	2020	This stimulation induced the upregulation of pro-IL-1beta mRNA and protein levels, and subsequently mature IL-1beta secretion, which was inhibited by metformin treatment.	Metformin	150-159	interleukin 1 beta	Homo sapiens	45-57
32118580-8	2020	Ivacaftor/tezacaftor alone showed a significant reduction in IL-1beta and pro-IL-1beta mRNA.	ivacaftor	0-9	interleukin 1 beta	Homo sapiens	74-86
32118580-8	2020	Ivacaftor/tezacaftor alone showed a significant reduction in IL-1beta and pro-IL-1beta mRNA.	tezacaftor	10-20	interleukin 1 beta	Homo sapiens	74-86
31877413-10	2020	Moreover, pretreatment with TUDCA restored suppression of TNF-alpha and IL-1beta expression and attenuated the enhanced viability of macrophages induced by gAcrp.	ursodoxicoltaurine	28-33	interleukin 1 beta	Homo sapiens	72-80
31758423-9	2020	IGU, MTX, and DXM dose dependently decreased the secretion of TNF-alpha, IL-1beta, IL-6, and IL-8 in neutrophils and PBMCs (P &lt; 0.05); the inhibitory effect of IGU was not significantly different from that of MTX and DXM.	Dexamethasone	14-17	interleukin 1 beta	Homo sapiens	73-81
31732996-8	2020	The WY-14643 increased expression of IL-1beta and IL-6 proteins, and the mRNA expression of IL-8 and LIF, decreased IL-4 expression, and did not affect the mRNA and protein expression of IL-10.	pirinixic acid	4-12	interleukin 1 beta	Homo sapiens	37-45
31802565-12	2020	Estrogen increased the proliferation and mobility of iheESCs and lipopolysaccharides (LPS) induced the IL-1beta and IL-6 promoting inflammatory response.	Estrogens	0-8	interleukin 1 beta	Homo sapiens	103-111
31758423-9	2020	IGU, MTX, and DXM dose dependently decreased the secretion of TNF-alpha, IL-1beta, IL-6, and IL-8 in neutrophils and PBMCs (P &lt; 0.05); the inhibitory effect of IGU was not significantly different from that of MTX and DXM.	Methotrexate	5-8	interleukin 1 beta	Homo sapiens	73-81
31943384-7	2020	The expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) that stimulated by wear particles were significantly reduced by GYY4137.	GYY 4137	178-185	interleukin 1 beta	Homo sapiens	59-76
32396972-0	2020	Effect of Sodium Bicarbonate Mouth Wash on Salivary pH and Interleukin-1beta Levels among Smokers.	Sodium Bicarbonate	10-28	interleukin 1 beta	Homo sapiens	59-76
31241425-8	2020	After UM, the significant up-regulation of TNF-alpha and hsa-miR-155 and down-regulation of IL-1beta were observed in the group with vitamin D supplementation.	Vitamin D	133-142	interleukin 1 beta	Homo sapiens	92-100
31943384-7	2020	The expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) that stimulated by wear particles were significantly reduced by GYY4137.	GYY 4137	178-185	interleukin 1 beta	Homo sapiens	78-86
31991371-5	2020	The results of our study show that tricetin suppressed oxidized low-density lipoprotein (ox-LDL)-induced expression of pro-inflammatory monocyte chemotactic protein-1 (MCP-1) and interleukin-1beta (IL-1beta), as well as the generation of reactive oxygen species (ROS).	tricetin	35-43	interleukin 1 beta	Homo sapiens	179-196
31927504-0	2020	Uric acid increases IL-1beta secretion and Caspase-1 activation in PBMCs of Behcet"s disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol.	Uric Acid	0-9	interleukin 1 beta	Homo sapiens	20-28
31927504-9	2020	Additionally, while UA has markedly increased NO, IL-1beta, and Caspase-1 activity levels in PBMCs of BD patients, Allopurinol has exerted an immunomodulatory effect resulting in reduced NO, IL-1beta and Caspase-1 levels in PBMCs of BD patients particularly during the active stages.	Uric Acid	20-22	interleukin 1 beta	Homo sapiens	50-58
31927504-9	2020	Additionally, while UA has markedly increased NO, IL-1beta, and Caspase-1 activity levels in PBMCs of BD patients, Allopurinol has exerted an immunomodulatory effect resulting in reduced NO, IL-1beta and Caspase-1 levels in PBMCs of BD patients particularly during the active stages.	Allopurinol	115-126	interleukin 1 beta	Homo sapiens	191-199
30922195-10	2020	Additionally, melatonin correlated positively with osteocalcin (r = 0.34, p = .04) and IL-1beta (r = 0.39, p = .04) in AS.	Melatonin	14-23	interleukin 1 beta	Homo sapiens	87-95
31808304-6	2020	Our data suggested that the PEI inhibited viability and E-cadherin expression of the pathological cells, and blocked the NF-kappaB signal pathway (reducing levels of p-NF-kappaB proteins); The loaded 5-Fu inhibited the inflammatory factors (TNF-alpha and IL-1beta) release and promoted the anti-inflammation/anti-tumor factors (IL-10 and IL-4) release from macrophages, and also suppressed pathological cells migration; Both the PEI and 5-Fu contributed to the upregulation of Bax and Caspase-3 (pro-tumor-apoptosis factor), as well as the downregulation of Bcl-2 (anti-tumor-apoptosis factor) in esophageal tumor cells.	poly(ethylene imine)	28-31	interleukin 1 beta	Homo sapiens	255-263
31338841-7	2020	Homocysteine (Hcy) decreased H 2 S expression while promoting the synthesis of IL-1beta and TNF-alpha in THP-1 and raw264.7 cells.	Homocysteine	14-17	interleukin 1 beta	Homo sapiens	79-87
31916911-0	2020	Magnolol Alleviates IL-1beta-Induced Dysfunction of Chondrocytes Through Repression of SIRT1/AMPK/PGC-1alpha Signaling Pathway.	magnolol	0-8	interleukin 1 beta	Homo sapiens	20-28
31916911-9	2020	Magnolol could alleviate IL-1beta-induced mitochondrial dysfunction and oxidative stress through SIRT1/AMPK/PGC-1alpha signaling pathway in human chondrocytes.	magnolol	0-8	interleukin 1 beta	Homo sapiens	25-33
31916911-11	2020	Furthermore, magnolol alleviated IL-1beta-induced inflammation in human chondrocytes.	magnolol	13-21	interleukin 1 beta	Homo sapiens	33-41
31916911-12	2020	Magnolol alleviates IL-1beta-induced dysfunction of chondrocytes through repressing SIRT1/AMPK/PGC-1alpha signaling pathway, which provides a potential new therapeutic strategy for human osteoarthritis.	magnolol	0-8	interleukin 1 beta	Homo sapiens	20-28
32237452-3	2020	Then, the ethanol extract of Epimedii Folium prepared according to the optimized technological conditions was used to intervene the injury model of chondrocyte induced by interleukin-1 beta(IL-1beta).	Ethanol	10-17	interleukin 1 beta	Homo sapiens	171-189
31790890-11	2020	A significant difference in nicotinamide adenine dinucleotide phosphate oxidase 2 concentrations was observed between T0 and T2 only in ADPKD patients treated with ALA (P = 0.039, P = 0.039; respectively), although we did not find a significant difference in interleukin-6, interleukin -1beta, and tumor necrosis factor-alpha concentrations in either group.	nicotinamide adenine	28-48	interleukin 1 beta	Homo sapiens	274-292
31790890-11	2020	A significant difference in nicotinamide adenine dinucleotide phosphate oxidase 2 concentrations was observed between T0 and T2 only in ADPKD patients treated with ALA (P = 0.039, P = 0.039; respectively), although we did not find a significant difference in interleukin-6, interleukin -1beta, and tumor necrosis factor-alpha concentrations in either group.	Thioctic Acid	164-167	interleukin 1 beta	Homo sapiens	274-292
31506572-4	2020	We showed that isosibiricin (10-50 muM) dose-dependently inhibited lipopolysaccharide (LPS)-induced BV-2 microglia activation, evidenced by the decreased expression of inflammatory mediators, including nitrite oxide (NO), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and interleukin-18 (IL-18).	Isosibiricin	15-27	interleukin 1 beta	Homo sapiens	305-313
31977025-7	2020	Specifically, high PA signal induced DSC apoptosis and formed an inflammatory program (elevated interleukin-1 beta and decreased interleukin-10) via the activation of TLR4/JNK/NF-kB pathways.	Palmitates	19-21	interleukin 1 beta	Homo sapiens	96-114
31998952-4	2020	In vivo and in vitro, IOP treatment caused renal damage and elevated the caspase-1 (+) PI (+) cell count, interleukin (IL)-1b and IL-18 levels, lactate dehydrogenase (LDH) release, and the relative expression of nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3), apoptosis-associated speck-like protein (ASC), and gasdermin D (GSDMD), suggesting that IOP induces AKI via the activation of pyroptosis.	iopromide	22-25	interleukin 1 beta	Homo sapiens	106-125
31734269-3	2020	THP-1 macrophages exposed to Cinacalcet (CaSR activator, 2 muM, 4 h) showed elevated proinflammatory marker and NLRP3 inflammasome mRNA, pro-IL-1beta protein and caspase-1 activity, whereas preincubation with CaSR negative modulators prevented these effects.	cina	29-39	interleukin 1 beta	Homo sapiens	137-149
31836142-5	2020	Furthermore, treatment with the JNK agonist anisomycin enhanced the damage to the joint cartilage and increased the levels of IL-1beta, IL-6 and TNF-alpha.	Anisomycin	44-54	interleukin 1 beta	Homo sapiens	126-134
31506572-4	2020	We showed that isosibiricin (10-50 muM) dose-dependently inhibited lipopolysaccharide (LPS)-induced BV-2 microglia activation, evidenced by the decreased expression of inflammatory mediators, including nitrite oxide (NO), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and interleukin-18 (IL-18).	Isosibiricin	15-27	interleukin 1 beta	Homo sapiens	286-303
31735734-0	2020	Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-kappaB signaling in IL-1beta-induced human synovial cells.	benzoylaconine	0-16	interleukin 1 beta	Homo sapiens	92-100
31830640-10	2020	PBMCs stimulated with silica crystals secreted IL-1beta.	Silicon Dioxide	22-28	interleukin 1 beta	Homo sapiens	47-55
31872359-0	2020	The link between interleukin-1beta and acute myocardial infarction in chronic myeloid leukemia patients treated with nilotinib: cross-sectional study.	nilotinib	117-126	interleukin 1 beta	Homo sapiens	17-34
31735734-2	2020	In this study, the effects and mechanisms of BAC on production of inflammatory cytokines interleukin (IL)-6 and IL-8 were investigated in IL-1beta-stimulated human synovial SW982 cells.	4-deoxyneosamine C	45-48	interleukin 1 beta	Homo sapiens	138-146
31735734-4	2020	The results revealed that BAC suppressed gene and protein expression of IL-6 and IL-8 induced by IL-1beta.	4-deoxyneosamine C	26-29	interleukin 1 beta	Homo sapiens	97-105
31735734-7	2020	The results demonstrate that BAC exerts an anti-inflammatory effect dependent on MAPK, Akt and nuclear factor-kappaB (NF-kappaB) pathways in human synovial cells stimulated with IL-1beta, suggesting that BAC may be exploited as a potential therapeutic agent for rheumatoid arthritis (RA) treatment.	4-deoxyneosamine C	29-32	interleukin 1 beta	Homo sapiens	178-186
31735734-7	2020	The results demonstrate that BAC exerts an anti-inflammatory effect dependent on MAPK, Akt and nuclear factor-kappaB (NF-kappaB) pathways in human synovial cells stimulated with IL-1beta, suggesting that BAC may be exploited as a potential therapeutic agent for rheumatoid arthritis (RA) treatment.	4-deoxyneosamine C	204-207	interleukin 1 beta	Homo sapiens	178-186
31935362-5	2020	In addition, the increased levels of TNF-alpha, IL-6 and IL-1beta in OGD/R-induced hippocampal neurons were significantly decreased by trigonelline pretreatment.	trigonelline	135-147	interleukin 1 beta	Homo sapiens	57-65
31935363-8	2020	Benzoquinone derivatives act as ROS-scavenging molecules, which modulated the TLR4-CD14 signaling pathway to inhibit the expression of procaspase-1 and IL-1beta in cells, induced apoptosis via a mitochondrial pathway by upregulating the ratio of Bax/Bcl-2 and by activating caspase-3, as well as inhibited the expression of the anti-apoptotic proteins FLIP and XIAP in activated LX-2 cells.	quinone	0-12	interleukin 1 beta	Homo sapiens	152-160
31699531-9	2020	Increased Co was associated with decreased tumor necrosis factor alpha (rho = -0.56, P = .01) and interleukin 1 beta (rho = -0.48, P = .03).	Cobalt	10-12	interleukin 1 beta	Homo sapiens	98-116
31933104-6	2020	SAK3 inhibited scopolamine-induced cellular apoptosis (morphologically and by determination of pro- and anti-apoptotic factor levels), increase in ROS levels, decrease in choline acetyltransferase level, phosphorylation of NF-kappaB, activation of Akt, JNK and p38 intracellular signaling pathways, and elevation of proinflammatory cytokines IL-1beta and IL-6, but not enhanced level of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).	Scopolamine	15-26	interleukin 1 beta	Homo sapiens	342-350
31789424-9	2020	In addition, ASB activated the production of Nrf2 and increased the mRNA expression levels of glutamate-cysteine ligase catalytic subunit and NAD(P)H quinone oxidoreductase 1, while ASB downregulated the protein expression of p65 and decreased the production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha.	sodium sulfate	13-16	interleukin 1 beta	Homo sapiens	262-284
31883986-6	2020	Both resveratrol and NDAT inhibited expression of pro-inflammatory IL-1beta and TNF-alpha.	resveratrol	5-16	interleukin 1 beta	Homo sapiens	67-75
31863917-7	2020	IL-1beta-induced injury was investigated by cell viability, apoptosis, autophagy and inflammatory response using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, flow cytometry, western blot and enzyme linked immunosorbent assay, respectively.	3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide	113-178	interleukin 1 beta	Homo sapiens	0-8
31680128-5	2020	RESULTS: Fipronil treatment increased pro-inflammatory cytokine interleukin (IL)-1beta, IL-6, IL-8, and MUC5AC expression in human primary nasal epithelial cells.	fipronil	9-17	interleukin 1 beta	Homo sapiens	64-86
31347162-0	2020	CD73-dependent adenosine dampens interleukin 1beta-induced CXCL8 production in gingival fibroblasts: Association with heme oxygenase-1 and adenosine monophosphate-activated protein kinase.	Adenosine	15-24	interleukin 1 beta	Homo sapiens	33-50
31347162-3	2020	Here, we investigated whether CD73-mediated hydrolysis of extracellular ATP (eATP) could affect interleukin (IL)-1beta-induced CXCL8 secretion.	Adenosine Triphosphate	72-75	interleukin 1 beta	Homo sapiens	96-118
31347162-9	2020	ATP pretreatment impaired IL-1beta-induced CXCL8 secretion and required activation of heme oxygenase-1 (HO-1) and phosphorylated adenosine monophosphate-activated protein kinase (pAMPK).	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	26-34
31347162-11	2020	CONCLUSIONS: CD73-generated adenosine dampens IL-1beta-induced CXCL8 in HGFs and involves HO-1 and pAMPK signaling.	Adenosine	28-37	interleukin 1 beta	Homo sapiens	46-54
31820013-8	2020	These results indicated that TRPA1 can mediate mtROS generation, mitochondrial membrane depolarization, the secretion of IL-1beta and cytotoxicity through cellular and mitochondrial Ca2+ influx in LPC-treated THP-1-derived macrophages.	Lysophosphatidylcholines	197-200	interleukin 1 beta	Homo sapiens	121-129
32554850-0	2020	Inhibitory effect of alpha-lipoic acid on mitochondrial dysfunction and interleukin-8 expression in interleukin-1beta-stimulated ataxia teleangiectasia fibroblasts.	Thioctic Acid	21-38	interleukin 1 beta	Homo sapiens	100-117
31698296-11	2020	An inverse correlation between serum selenium concentration and several proinflammatory cytokines (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha) was found.	Selenium	37-45	interleukin 1 beta	Homo sapiens	99-116
31840428-0	2020	Correlation Analysis of C-terminal telopeptide of collagen type II and Interleukin-1beta for Early Diagnosis of Knee Osteoarthritis.	Carbon	0-1	interleukin 1 beta	Homo sapiens	71-88
31840428-14	2020	Moreover, there was a positive correlation between CTX-II and IL-1beta of all subjects (r = 0.974, P &lt; 0.001), between K-L score and urine concentration of CTX-II (r = 0.900, P &lt; 0.001), and between K-L score and IL-1beta (r = 0.813, P &lt; 0.001) of all subjects.	ciguatoxin 1B (CTX 1B)	51-57	interleukin 1 beta	Homo sapiens	62-70
31840428-14	2020	Moreover, there was a positive correlation between CTX-II and IL-1beta of all subjects (r = 0.974, P &lt; 0.001), between K-L score and urine concentration of CTX-II (r = 0.900, P &lt; 0.001), and between K-L score and IL-1beta (r = 0.813, P &lt; 0.001) of all subjects.	ciguatoxin 1B (CTX 1B)	159-165	interleukin 1 beta	Homo sapiens	219-227
31840428-18	2020	Moreover, there was a positive correlation between the serum concentration of IL-1beta and CTX-II (r = 0.967, P &lt; 0.001).	ciguatoxin 1B (CTX 1B)	91-97	interleukin 1 beta	Homo sapiens	78-86
31680128-9	2020	CONCLUSIONS: Fipronil induced pro-inflammatory cytokine IL-1beta, IL-6, IL-8, and MUC5AC expression via ERK1/2 MAPK, p38 MAPK, and NF-kB in human primary nasal epithelial cells.	fipronil	13-21	interleukin 1 beta	Homo sapiens	56-64
31991717-4	2020	In our experimental model, main carnosine beneficial effects were: (1) the modulation of nitric oxide production and metabolism; (2) the amelioration of the macrophage energy state; (3) the decrease of the expressions of pro-oxidant enzymes (Nox-2, Cox-2) and of the lipid peroxidation product malondialdehyde; (4) the restoration and/or increase of the expressions of antioxidant enzymes (Gpx1, SOD-2 and Cat); (5) the increase of the transforming growth factor-beta1 (TGF-beta1) and the down-regulation of the expressions of interleukins 1beta and 6 (IL-1beta and IL-6) and 6) the increase of the expressions of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 (HO-1).	Carnosine	32-41	interleukin 1 beta	Homo sapiens	527-551
31672627-7	2020	Correlation analysis indicates a negative correlation of 25(OH)D with IL-6, IL-1beta, TNF-alpha, and Ox-LDL among total subjects.	25-hydroxyvitamin D3-bromoacetate	57-64	interleukin 1 beta	Homo sapiens	76-84
31672627-8	2020	Further, logistics regression analysis demonstrated a significant association of different categories of 25(OH)D with IL-6, IL-1beta, TNF-alpha, and Ox-LDL before and after adjustment to body mass index and waist to hip ratio.	25-hydroxyvitamin D3-bromoacetate	105-112	interleukin 1 beta	Homo sapiens	124-132
31574241-8	2020	Nur77 and 6-MP may provide a basis to develop a new treatment for patients who suffer from embryo adhesion dysfunction.Abbreviations: HB-EGF: heparin-binding epidermal growth factor-like growth factor; HOXA10: homeobox A10; NGFI-B: nerve growth factor-induced gene B; RIF: recurrent implantation failure; RPL: recurrent pregnancy loss; 6-MP: 6-mercaptopurine; IGFBP-1: insulin-like growth factor binding protein-1; LIF: leukemia inhibitory factor; IL-1beta: Interleukin - 1beta; CRISPR/Cas9: Clustered Regularly Interspaced Short Palindromic Repeats; AF-1: activation function-1 domain; HIF-1alpha: hypoxia-inducible factor 1alpha; CREB: cAMP response element binding.	Heparin	142-149	interleukin 1 beta	Homo sapiens	458-477
32076422-5	2020	Morphine-exposure of RM-PBMCs infected with SHIVs 4NF-kappaB, 3NF-kappaB, and AD8EO altered cellular transcript levels of monocyte chemoattractant protein 1, interleukin 6, interleukin 1beta, and Tumor Necrosis Factor alpha.	Morphine	0-8	interleukin 1 beta	Homo sapiens	173-190
31743809-6	2020	Two hours after exercise, interleukin (IL)-1beta decreased compared with post-exercise in placebo and was lower compared with baseline in the CHO + Gln condition.	dithiiranylmethyloxy azaxanthone	142-145	interleukin 1 beta	Homo sapiens	26-48
31743809-6	2020	Two hours after exercise, interleukin (IL)-1beta decreased compared with post-exercise in placebo and was lower compared with baseline in the CHO + Gln condition.	arginyl-glutamine	148-151	interleukin 1 beta	Homo sapiens	26-48
31876682-5	2020	Also, DHT inhibited HG-induced expression of TNF-alpha and IL-1beta.	Dihydrotestosterone	6-9	interleukin 1 beta	Homo sapiens	59-67
31830726-5	2020	Atorvastatin inhibited pyroptosis by decreasing the expression levels of the canonical inflammasome pathway biomarkers NLRP3, caspase-1, GSDMD, IL-1beta, and IL-18 at both the mRNA and protein levels.	atorvastatin	0-12	interleukin 1 beta	Homo sapiens	144-152
31759058-5	2020	Pretreatment with CLI-095, a specific inhibitor of TLR4 signaling, dramatically diminished the TLMP-induced release of IL-1beta and IL-18 by inhibiting the formation of NLRP3/ASC/pro-caspase-1 inflammasome in a dose-dependent manner.	tlmp	95-99	interleukin 1 beta	Homo sapiens	119-127
31678609-0	2020	The impact of progesterone and RU-486 on classic pro-labour proteins &amp; contractility in human myometrial tissues during 24-hour exposure to tension &amp; Interleukin-1beta.	Mifepristone	31-37	interleukin 1 beta	Homo sapiens	158-175
31678609-8	2020	Interleukin-1beta (IL-1beta; 1 ng/ml) enhanced COX-2 protein and PGE2 content in un-stretched tissues.	Dinoprostone	65-69	interleukin 1 beta	Homo sapiens	0-17
31678609-8	2020	Interleukin-1beta (IL-1beta; 1 ng/ml) enhanced COX-2 protein and PGE2 content in un-stretched tissues.	Dinoprostone	65-69	interleukin 1 beta	Homo sapiens	19-27
31938471-3	2020	Hence, this study was aimed to investigate whether high concentration of glucose (HG), which mimics the hyperglycemia environment, could initiate vascular calcification through NLRP3/IL-1beta inflammasome and the underlying mechanism.	Glucose	73-80	interleukin 1 beta	Homo sapiens	183-191
31938471-10	2020	Moreover, 6-shogaol could inhibit the Akt/ROS signaling and NLRP3/caspase 1/IL-1beta inflammasome and hence attenuated HASMC calcification.	shogaol	10-19	interleukin 1 beta	Homo sapiens	76-84
31938471-11	2020	Conclusions: This study elucidates the detailed mechanism of HG-initiated HASMC calcification through NLRP3/caspase 1/IL-1beta inflammasome and indicates a potential therapeutic role of 6-shogaol in vascular calcification complication of diabetes.	shogaol	186-195	interleukin 1 beta	Homo sapiens	118-126
31669486-5	2020	Oestrogen can decrease IVD cell apoptosis in multiple ways, including the inhibition of the inflammatory cytokines IL-1beta and TNF-alpha, reducing catabolism because of inhibition of matrix metalloproteinases, upregulating integrin alpha2beta1 and IVD anabolism, activating the PI3K/Akt pathway, decreasing oxidative damage and promoting autophagy.	Estrogens	0-9	interleukin 1 beta	Homo sapiens	115-123
32420752-8	2020	A variety of pain-related substances released by glial cells such as the proinflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, interleukin-6, and prostaglandins such as prostaglandins E2 can also be reduced.	Dinoprostone	189-206	interleukin 1 beta	Homo sapiens	128-145
31483910-8	2020	RESULTS: After treatment with resveratrol, it was found that serum levels of IL-6, IL-1beta, TNF-alpha, IL-18, NF-kappaB, and CRP decreased in treatment group.	Resveratrol	30-41	interleukin 1 beta	Homo sapiens	83-91
31734849-10	2020	Arsenic could also trigger the induction of GATA4-NF-kappaB signaling and senescence-associated secretory phenotype (SASP) by increasing IL-1alpha, IL-1beta, TGF-beta, TNF-alpha, CCL2, PAI-1, and MMP13 mRNA expression.	Arsenic	0-7	interleukin 1 beta	Homo sapiens	148-156
31953420-3	2020	Previously, we demonstrated that HST decreased interleukin 1beta-induced prostaglandin E2 production in human oral keratinocytes (HOKs) and OUM-induced mechanical or spontaneous pain in rats.	Dinoprostone	73-89	interleukin 1 beta	Homo sapiens	47-64
31711985-4	2020	This study showed that miR-425-5p was significantly upregulated in diabetic patients and human umbilical vein endothelial cells (HUVECs) treated with high glucose (HG) and interleukin-1beta (IL-1beta).	Glucose	155-162	interleukin 1 beta	Homo sapiens	191-199
31931832-12	2020	Besides, the intrathecal injection of exogenous BDNF further decreased the mechanical withdrawal threshold, promoted activation of astrocytes and microglia, and increased the release of TNF-alpha and IL-1beta in the SDH of our CYP-induced cystitis model.	Cyclophosphamide	227-230	interleukin 1 beta	Homo sapiens	200-208
31931832-13	2020	CONCLUSIONS: In our CYP-induced cystitis model, BDNF promoted the activation of astrocytes and microglia to release TNF-alpha and IL-1beta, aggravating neuroinflammation and leading to mechanical allodynia through BDNF-TrkB-p38/JNK signaling.	Cyclophosphamide	20-23	interleukin 1 beta	Homo sapiens	130-138
31900165-0	2020	IL-1beta induces rod degeneration through the disruption of retinal glutamate homeostasis.	Glutamic Acid	68-77	interleukin 1 beta	Homo sapiens	0-8
31900165-5	2020	Glutamate receptor antagonists were evaluated for their ability to reduce photoreceptor cell death in the presence of IL1-beta or monocytes.	Glutamic Acid	0-9	interleukin 1 beta	Homo sapiens	118-126
31900165-7	2020	We demonstrate that IL-1beta leads to glutamate-induced rod photoreceptor cell death as it increases the extracellular glutamate concentrations in the retina through the inhibition of its conversion to glutamine in Muller cells, increased release from Muller cells, and diminished reuptake.	Glutamic Acid	38-47	interleukin 1 beta	Homo sapiens	20-28
31900165-7	2020	We demonstrate that IL-1beta leads to glutamate-induced rod photoreceptor cell death as it increases the extracellular glutamate concentrations in the retina through the inhibition of its conversion to glutamine in Muller cells, increased release from Muller cells, and diminished reuptake.	Glutamic Acid	119-128	interleukin 1 beta	Homo sapiens	20-28
31900165-7	2020	We demonstrate that IL-1beta leads to glutamate-induced rod photoreceptor cell death as it increases the extracellular glutamate concentrations in the retina through the inhibition of its conversion to glutamine in Muller cells, increased release from Muller cells, and diminished reuptake.	arginyl-glutamine	202-211	interleukin 1 beta	Homo sapiens	20-28
31900165-8	2020	The inhibition of non-NMDA receptors completely and efficiently prevented rod apoptosis in retinal explants cultured in the presence of IL-1beta or, more importantly, in vivo, in a model of subretinal inflammation.	N-Methylaspartate	22-26	interleukin 1 beta	Homo sapiens	136-144
31900165-9	2020	CONCLUSIONS: Our study emphasizes the importance of inflammation in the deregulation of glutamate homeostasis and provides a comprehensive mechanism of action for IL-1beta-induced rod degeneration.	Glutamic Acid	88-97	interleukin 1 beta	Homo sapiens	163-171
31706101-9	2020	We found that DHP inhibited IL-1beta-induced upregulation of ROS, TNF-alpha, IL-6, MMP-3, ADAMTS-5.	1,4-dihydropyridine	14-17	interleukin 1 beta	Homo sapiens	28-36
31706101-11	2020	Furthermore, DHP significantly protected the IL-1beta-induced degradation of collagen-II and aggrecan.	1,4-dihydropyridine	13-16	interleukin 1 beta	Homo sapiens	45-53
31648019-5	2020	Treatment of human TM cells with dexamethasone, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) increased the levels of autotaxin protein, a response that was mitigated by inhibitors of glucocorticoid receptor, NF-kB and SMAD3.	Dexamethasone	33-46	interleukin 1 beta	Homo sapiens	111-119
31486753-0	2020	Down-regulation of MiR-138-5p Protects Chondrocytes ATDC5 and CHON-001 from IL-1 beta-induced Inflammation Via Up-regulating SOX9.	mir-138-5p	19-29	interleukin 1 beta	Homo sapiens	76-85
31734578-10	2020	Moreover, in vivo, the combination of SFJDC and oseltamivir improved survival rates, attenuated clinical symptoms, induced weight gain, alleviated lung damage, and significantly reduced IL-1beta and IL-18 levels in serum and BALF, as well as reduced the expression levels of NLRP3-associated components and viral titers in lung homogenates.	Oseltamivir	48-59	interleukin 1 beta	Homo sapiens	186-194
31486753-0	2020	Down-regulation of MiR-138-5p Protects Chondrocytes ATDC5 and CHON-001 from IL-1 beta-induced Inflammation Via Up-regulating SOX9.	chon	62-66	interleukin 1 beta	Homo sapiens	76-85
31486753-16	2020	This study revealed the protective effect of down-regulated miR-138-5p on inflammatory injury of chondrocytes caused by IL-1beta.	mir-138-5p	60-70	interleukin 1 beta	Homo sapiens	120-128
31472402-4	2020	TB-KDM individuals exhibit significantly higher levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-1alpha, IL-1beta and IL-6 in comparison to TB-NDM, TB alone and DM alone individuals.	Terbium	0-2	interleukin 1 beta	Homo sapiens	103-111
31660813-4	2020	Increased proinflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta) are secreted by monocytes due to the dicarbonyl-modified proteins.	1,4-dicarbonyl butene	125-135	interleukin 1 beta	Homo sapiens	69-86
31472402-7	2020	TB-NDM individuals are also characterized by significantly diminished TB-antigen stimulated levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-17F, IL-1alpha, IL-1beta and/or IL-6 at pre-treatment and at 2  months of ATT and IFNgamma, IL-2, IL-1alpha and IL-1beta at post-treatment.	Terbium	0-2	interleukin 1 beta	Homo sapiens	155-163
31472402-7	2020	TB-NDM individuals are also characterized by significantly diminished TB-antigen stimulated levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-17F, IL-1alpha, IL-1beta and/or IL-6 at pre-treatment and at 2  months of ATT and IFNgamma, IL-2, IL-1alpha and IL-1beta at post-treatment.	Terbium	0-2	interleukin 1 beta	Homo sapiens	251-259
31885713-9	2020	Furthermore, NaHS inhibited the expression of NLRP3, ASC and cleaved caspase-1, and the production of IL-1beta and IL-18 in adipocytes treated with HG.	Sodium	13-17	interleukin 1 beta	Homo sapiens	102-110
31971835-11	2020	Al activated extracellular signal-regulated kinase 1/2 and nuclear factor-kappa B (NF-kappaB), resulting in mRNA expression of matrix metalloproteinase-9, myosin light-chain kinase, and inflammatory cytokines [tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6] in HT-29 cells.	Aluminum	0-2	interleukin 1 beta	Homo sapiens	251-268
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	Glucose	126-134	interleukin 1 beta	Homo sapiens	153-161
31914640-4	2020	Here we show that ginsenoside Rg3 blocks IL-1beta secretion and caspase-1 activation through inhibiting LPS priming and the NLRP3 inflammasome activation in human and mouse macrophages.	ginsenoside Rg3	18-33	interleukin 1 beta	Homo sapiens	41-49
31810887-4	2020	Here we show that exposure of human gingival fibroblasts to IL-1beta increases expression of maintenance methyltransferase DNMT1 but decreases expression of de novo methyltransferase DNMT3a and the demethylating enzyme TET1, while exposure to PGE2 decreases expression of all three enzymes.	Dinoprostone	243-247	interleukin 1 beta	Homo sapiens	60-68
30843768-4	2020	Only the concentration of IL-1beta in culture media from cells exposed to 27.5 mM dextrose increased relative to cells maintained in 5.5 mM dextrose.	Glucose	82-90	interleukin 1 beta	Homo sapiens	26-34
30843768-4	2020	Only the concentration of IL-1beta in culture media from cells exposed to 27.5 mM dextrose increased relative to cells maintained in 5.5 mM dextrose.	Glucose	140-148	interleukin 1 beta	Homo sapiens	26-34
31330080-5	2020	Based on the results from loss-of-function studies, SGK1 silencing promoted the deposition of glycosaminoglycans in interleukin 1 beta (IL-1beta)-treated chondrocytes, and significantly alleviated IL-1beta-induced downregulation of Collagen II and Aggrecan, as well as the upregulation of a disintegrin and metalloproteinase with thrombospondin motifs 5 and matrix metalloproteinase-13.	Glycosaminoglycans	94-112	interleukin 1 beta	Homo sapiens	116-134
31330080-5	2020	Based on the results from loss-of-function studies, SGK1 silencing promoted the deposition of glycosaminoglycans in interleukin 1 beta (IL-1beta)-treated chondrocytes, and significantly alleviated IL-1beta-induced downregulation of Collagen II and Aggrecan, as well as the upregulation of a disintegrin and metalloproteinase with thrombospondin motifs 5 and matrix metalloproteinase-13.	Glycosaminoglycans	94-112	interleukin 1 beta	Homo sapiens	136-144
31680470-3	2020	(R)-salbutamol significantly inhibited LPS-induced M1 macrophage polarization and downregulated expressions of typical M1 macrophage cytokines, including monocyte chemotactic protein-1 (MCP-1), interleukin-1beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha).	Albuterol	0-14	interleukin 1 beta	Homo sapiens	194-211
31680470-3	2020	(R)-salbutamol significantly inhibited LPS-induced M1 macrophage polarization and downregulated expressions of typical M1 macrophage cytokines, including monocyte chemotactic protein-1 (MCP-1), interleukin-1beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha).	Albuterol	0-14	interleukin 1 beta	Homo sapiens	213-221
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	alpha-Tocopherol	15-31	interleukin 1 beta	Homo sapiens	153-161
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	Glucose	126-134	interleukin 1 beta	Homo sapiens	264-272
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	alpha-Tocopherol	15-31	interleukin 1 beta	Homo sapiens	264-272
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	Ascorbic Acid	61-74	interleukin 1 beta	Homo sapiens	153-161
30843768-6	2020	However, ebselen treatment reduced IL-1beta, IL-6, and IL-8 levels in cells maintained in either 5.5 or 27.5 mM dextrose.	ebselen	9-16	interleukin 1 beta	Homo sapiens	35-43
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	Ascorbic Acid	61-74	interleukin 1 beta	Homo sapiens	264-272
31714673-8	2020	Activation of A3AR by 2-Cl-IB-MECA significantly decreased TNF-alpha and IL-1beta production and attenuated the NF-kappaBp65 activation in colonic tissues from UC patients.	2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide	22-34	interleukin 1 beta	Homo sapiens	73-81
31693860-5	2020	Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability.	vorinostat	10-41	interleukin 1 beta	Homo sapiens	227-231
31693860-5	2020	Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability.	vorinostat	43-47	interleukin 1 beta	Homo sapiens	227-231
31693860-5	2020	Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability.	givinostat hydrochloride	56-63	interleukin 1 beta	Homo sapiens	227-231
31693860-5	2020	Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability.	givinostat	65-75	interleukin 1 beta	Homo sapiens	227-231
31603717-8	2020	PCB2 prevented LPS-induced tumor necrosis factor-alpha, interleukin-1beta expression, NF-kappaB activation, and NLRP3 inflammasome activation.	procyanidin B	0-4	interleukin 1 beta	Homo sapiens	56-73
32612008-7	2020	Moreover, DHP-3 suppressed the mRNA expression of tumor necrosis factor-alpha (TNFalpha), and interleukin-1 beta (IL-1beta).	dhp-3	10-15	interleukin 1 beta	Homo sapiens	94-112
31497913-5	2020	The results demonstrated that quercetin can significantly inhibit expression and secretion of IL-1beta, IL-6, and TNF-alpha in LPS-induced bone marrow-derived macrophages (BMDMs) and reduce activity of Mincle/Syk/NF-kappaB signaling in vitro.	Quercetin	30-39	interleukin 1 beta	Homo sapiens	94-102
32564014-4	2020	THC significantly suppressed LPS-induced interleukin-1beta production and intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression and significantly decreased LPS-induced nuclear factor-kappaB activation by attenuating p65 phosphorylation and inhibitor of kappa B degradation.	Dronabinol	0-3	interleukin 1 beta	Homo sapiens	41-58
31785208-0	2020	Apigenin Reverses Interleukin-1beta-induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes.	Apigenin	0-8	interleukin 1 beta	Homo sapiens	18-35
31680318-3	2020	Findings suggest that neurotoxins, aggregation of alpha-synuclein, mitochondrial reactive oxygen species, and disrupted mitophagy are the key regulators of microglial leucine-rich-repeat- and pyrin-domain-containing 3 inflammasome activation and release of interleukin-1beta and interleukin-18 caspase-1-mediated pyroptotic cell death in the substantia nigra of the brain.	leucylleucine	167-174	interleukin 1 beta	Homo sapiens	257-274
32552358-2	2020	The urate monosodium crystals deposit initiates an inflammatory response; mediated by NLRP3 inflammasome, with the release of interleukin 1beta.	Uric Acid	4-20	interleukin 1 beta	Homo sapiens	126-143
31497913-6	2020	We also found that quercetin can strongly reduce the concentration of serum creatinine, BUN, IL-1beta, IL-6, and TNF-alpha in cisplatin-induced AKI model.	Cisplatin	126-135	interleukin 1 beta	Homo sapiens	93-101
33012733-9	2020	Additionally, the administration of rCC16 significantly attenuated the increase of pro-IL-1beta, NLRP3 and caspase-1 levels induced by silica particle exposure.	Silicon Dioxide	135-141	interleukin 1 beta	Homo sapiens	83-95
31834252-7	2020	RESULTS: There was a decrease in total cholesterol, triglycerides, low-density lipoprotein, C-reactive protein, fibrinogen, interleukin (IL)-1beta and right carotid intima-media thickness in the STA, PLET, and STAET groups compared with PL group (P &lt; 0.001).	Simvastatin	195-198	interleukin 1 beta	Homo sapiens	124-146
31785208-0	2020	Apigenin Reverses Interleukin-1beta-induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes.	Dinoprostone	87-91	interleukin 1 beta	Homo sapiens	18-35
31785208-2	2020	In this study, we investigated impacts of apigenin (Apg), a natural flavonoid with anti-inflammatory properties, on IL-1beta activation and adipocyte browning.	Apigenin	42-50	interleukin 1 beta	Homo sapiens	116-124
31785208-2	2020	In this study, we investigated impacts of apigenin (Apg), a natural flavonoid with anti-inflammatory properties, on IL-1beta activation and adipocyte browning.	Apigenin	52-55	interleukin 1 beta	Homo sapiens	116-124
31785208-3	2020	METHODS AND RESULTS: Apg protected cAMP-induced browning from IL-1beta in primary human adipocytes as evidenced by increased expression of brown-specific markers, mitochondrial content, and respiratory function.	Apigenin	21-24	interleukin 1 beta	Homo sapiens	62-70
31785208-3	2020	METHODS AND RESULTS: Apg protected cAMP-induced browning from IL-1beta in primary human adipocytes as evidenced by increased expression of brown-specific markers, mitochondrial content, and respiratory function.	Cyclic AMP	35-39	interleukin 1 beta	Homo sapiens	62-70
31785208-4	2020	Apg significantly repressed inflammatory markers and NF-kappaB activation induced by IL-1beta in these adipocytes.	Apigenin	0-3	interleukin 1 beta	Homo sapiens	85-93
31785208-5	2020	Intriguingly, Apg profoundly induced cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) gene expression in response to IL-1beta treatment.	Apigenin	14-17	interleukin 1 beta	Homo sapiens	120-128
31785208-5	2020	Intriguingly, Apg profoundly induced cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) gene expression in response to IL-1beta treatment.	Dinoprostone	65-81	interleukin 1 beta	Homo sapiens	120-128
31785208-5	2020	Intriguingly, Apg profoundly induced cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) gene expression in response to IL-1beta treatment.	Dinoprostone	83-87	interleukin 1 beta	Homo sapiens	120-128
31785208-6	2020	Conversely, COX2 pharmacological inhibition or RNA silencing attenuated the positive effect of Apg on adipocyte browning in IL-1beta treated cells.	Apigenin	95-98	interleukin 1 beta	Homo sapiens	124-132
31785208-8	2020	The effect of Apg on adipocyte browning in IL-1beta-treated adipocytes was accompanied by an elevation in intracellular Ca2+ , partly due to TRPV1/4 receptor activation.	Apigenin	14-17	interleukin 1 beta	Homo sapiens	43-51
31785208-8	2020	The effect of Apg on adipocyte browning in IL-1beta-treated adipocytes was accompanied by an elevation in intracellular Ca2+ , partly due to TRPV1/4 receptor activation.	Calcium	120-124	interleukin 1 beta	Homo sapiens	43-51
31595775-8	2020	ACTA-2, IL-1beta, and N-cadherin immunoreactivities were significantly decreased, whereas TNF-alpha and vimentin immunoreactivities significantly increased in quercetin-treated CD133+ cells.	Quercetin	159-168	interleukin 1 beta	Homo sapiens	8-16
31497913-6	2020	We also found that quercetin can strongly reduce the concentration of serum creatinine, BUN, IL-1beta, IL-6, and TNF-alpha in cisplatin-induced AKI model.	Quercetin	19-28	interleukin 1 beta	Homo sapiens	93-101
31102177-7	2020	Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis.	Aspartic Acid	8-11	interleukin 1 beta	Homo sapiens	99-107
31765890-10	2020	Specifically, in GPx1 kd cells IL-1beta stimulation led to a dramatic shift of the PGE2/PGD2 ratio towards pro-inflammatory PGE2.	Dinoprostone	83-87	interleukin 1 beta	Homo sapiens	31-39
31765890-10	2020	Specifically, in GPx1 kd cells IL-1beta stimulation led to a dramatic shift of the PGE2/PGD2 ratio towards pro-inflammatory PGE2.	Dinoprostone	124-128	interleukin 1 beta	Homo sapiens	31-39
31504930-0	2020	Monosodium urate crystal interleukin-1beta release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation.	Uric Acid	0-16	interleukin 1 beta	Homo sapiens	25-42
31102177-7	2020	Glu and Asp supplementation also modulated the expression of TGF-beta1, IL-10, TNF-alpha, IL-6 and IL-1beta in the testis and epididymis.	Glutamic Acid	0-3	interleukin 1 beta	Homo sapiens	99-107
31707353-5	2020	A decreased expression of IL-1beta was observed in both G6PD-deficient PBMCs and PMA-primed G6PD-knockdown (G6PD-kd) THP-1 cells upon lipopolysaccharide (LPS)/adenosine triphosphate (ATP) or LPS/nigericin stimulation.	20-oxo-20-deoxy-12-myristate 13-acetate	81-84	interleukin 1 beta	Homo sapiens	26-34
31707353-5	2020	A decreased expression of IL-1beta was observed in both G6PD-deficient PBMCs and PMA-primed G6PD-knockdown (G6PD-kd) THP-1 cells upon lipopolysaccharide (LPS)/adenosine triphosphate (ATP) or LPS/nigericin stimulation.	Adenosine Triphosphate	159-181	interleukin 1 beta	Homo sapiens	26-34
31707353-5	2020	A decreased expression of IL-1beta was observed in both G6PD-deficient PBMCs and PMA-primed G6PD-knockdown (G6PD-kd) THP-1 cells upon lipopolysaccharide (LPS)/adenosine triphosphate (ATP) or LPS/nigericin stimulation.	Nigericin	195-204	interleukin 1 beta	Homo sapiens	26-34
32646363-9	2020	Also, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1beta, as well as between Serum urate levels and hypertension severity.	Uric Acid	53-58	interleukin 1 beta	Homo sapiens	93-110
31639409-4	2020	It was found that acrolein increased the levels of NLRP3 and cleaved caspase-1, which led to the maturation of interleukin-1beta (IL-1beta).	Acrolein	18-26	interleukin 1 beta	Homo sapiens	111-128
32844633-0	2020	[The influence of fluoxetine on interleukin-6 and interleukin-1beta production by dendritic cells in multiple sclerosis in vitro].	Fluoxetine	18-28	interleukin 1 beta	Homo sapiens	50-67
32844633-1	2020	THE AIM OF THE STUDY: Was to evaluate the effect of selective serotonin reuptake inhibitor fluoxetine on the production of cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) by dendritic cells in multiple sclerosis (MS).	Serotonin	62-71	interleukin 1 beta	Homo sapiens	158-175
32844633-1	2020	THE AIM OF THE STUDY: Was to evaluate the effect of selective serotonin reuptake inhibitor fluoxetine on the production of cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) by dendritic cells in multiple sclerosis (MS).	Fluoxetine	91-101	interleukin 1 beta	Homo sapiens	158-175
31882798-4	2019	Dendritic cells and macrophages derived from murine bone marrow and human peripheral blood mononucleated cells stimulated with calcium-oxalate crystals, monosodium urate crystals, or ATP lead to the robust release of interleukin-1beta (IL-1ss).	Calcium Oxalate	127-142	interleukin 1 beta	Homo sapiens	217-234
31920355-12	2019	Further investigation indicated that Salidroside down-regulated the mRNA expression of IL-1beta and IL-6-pro-inflammatory cytokines.	rhodioloside	37-48	interleukin 1 beta	Homo sapiens	87-95
31882798-4	2019	Dendritic cells and macrophages derived from murine bone marrow and human peripheral blood mononucleated cells stimulated with calcium-oxalate crystals, monosodium urate crystals, or ATP lead to the robust release of interleukin-1beta (IL-1ss).	Uric Acid	153-169	interleukin 1 beta	Homo sapiens	217-234
31882798-4	2019	Dendritic cells and macrophages derived from murine bone marrow and human peripheral blood mononucleated cells stimulated with calcium-oxalate crystals, monosodium urate crystals, or ATP lead to the robust release of interleukin-1beta (IL-1ss).	Adenosine Triphosphate	183-186	interleukin 1 beta	Homo sapiens	217-234
31950055-8	2019	Anti-CD14 antibody treatment prior to ATRA and flagellin treatments completely abolished ATRA-enhanced TNF-alpha and IL-1beta production.	Tretinoin	89-93	interleukin 1 beta	Homo sapiens	117-125
31949440-6	2019	Through the p38 MAPK signaling pathway inhibitor SB 203580, we found that IL-1beta induces the expression of LFA-1 through p38 MAPK signaling and enhances ICAM-1 expression in HUVECs.	SB 203580	49-58	interleukin 1 beta	Homo sapiens	74-82
31949440-7	2019	In addition, IL-1beta-induced MSC adhesion to HUVECs was found to be inhibited by IL-1RA and the LFA-1 inhibitor lovastatin.	Lovastatin	113-123	interleukin 1 beta	Homo sapiens	13-21
31949464-11	2019	Granule of BU-XIN RUAN-MAI significantly improved oxidation stress by increasing PPARalpha expression, and it inhibited inflammation by downregulating expression and contents of IL-6, IL-1beta, and TNF-alpha.	poly-5-bromouridylic acid	11-22	interleukin 1 beta	Homo sapiens	184-192
31950055-4	2019	Similarly, ATRA enhanced the expression and production of TNF-alpha and IL-1beta in THP-1 cells upon flagellin challenge.	Tretinoin	11-15	interleukin 1 beta	Homo sapiens	72-80
31729530-2	2019	Moracin treatment significantly inhibited the LPS-induced inflammatory cytokine accumulation (IL-1beta, IL-6 and TNF-alpha) in nucleus pulposus cells.	moracin C	0-7	interleukin 1 beta	Homo sapiens	94-102
31870428-2	2019	Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLRP3 inflammasome, thereby inducing the secretion of proinflammatory IL-1beta and IL-18, leading to the aggravation of the downstream inflammatory response.	Oxygen	9-15	interleukin 1 beta	Homo sapiens	164-172
31927560-0	2019	Naringin Protects Against Interleukin 1beta (IL-1beta)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-kappaB) Pathway and p53 Expression.	naringin	0-8	interleukin 1 beta	Homo sapiens	26-43
31873180-6	2019	Next, interleukin (IL) 1beta, TNF, and Malt-1 expression in RAW 264.7 macrophages treated with the S. suieae acetyl-xylogalactan was investigated through real-time quantitative polymerase chain reaction, and the results demonstrated that S. suieae acetyl-xylogalactan induced IL-1beta and Malt-1 expression.	acetyl phosphate	109-128	interleukin 1 beta	Homo sapiens	276-284
31679024-12	2019	Vitamin B6 had significantly increased the mRNA expression of interleukin-1beta, tumor necrosis factor-alpha,cyclo-oxygen-ase-2, and transforming growth factor-beta (P < 0.05).	Vitamin B 6	0-10	interleukin 1 beta	Homo sapiens	62-79
31539553-5	2019	We found that agonism of GPR39 using its specific agonist TC-G 1008 significantly ameliorated important markers of RA, including oxidative stress, mitochondrial dysfunction, expression of proinflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and monocyte chemoattractant protein 1 (MCP-1), and secretion of key matrix metalloproteinases (MMPs) including MMP-1, MMP-3 and MMP-13.	GPR39-C3	58-67	interleukin 1 beta	Homo sapiens	224-241
31539553-5	2019	We found that agonism of GPR39 using its specific agonist TC-G 1008 significantly ameliorated important markers of RA, including oxidative stress, mitochondrial dysfunction, expression of proinflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and monocyte chemoattractant protein 1 (MCP-1), and secretion of key matrix metalloproteinases (MMPs) including MMP-1, MMP-3 and MMP-13.	GPR39-C3	58-67	interleukin 1 beta	Homo sapiens	243-251
31820601-12	2019	CONCLUSION: Acupuncture combined with Jingtong granule have significant clinical efficacy for nerve-root type cervical spondylosis, which could reduce the serum levels of IL-6, TNF-alpha and IL-1beta and improve hemorheology.	SELAPINA	47-54	interleukin 1 beta	Homo sapiens	191-199
31915516-4	2019	In an in vitro OA environment induced by interleukin-1 beta (IL-1beta), melatonin treatment improved cell proliferation of human chondrocytes, promoted the expression of cartilage ECM proteins (e.g., type II collagen and aggrecan), and inhibited the levels of IL-1beta-induced proteinases, such as matrix metalloproteinase 9 (MMP9), MMP13, ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4), and ADAMTS5.	Melatonin	72-81	interleukin 1 beta	Homo sapiens	41-59
31915516-4	2019	In an in vitro OA environment induced by interleukin-1 beta (IL-1beta), melatonin treatment improved cell proliferation of human chondrocytes, promoted the expression of cartilage ECM proteins (e.g., type II collagen and aggrecan), and inhibited the levels of IL-1beta-induced proteinases, such as matrix metalloproteinase 9 (MMP9), MMP13, ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4), and ADAMTS5.	Melatonin	72-81	interleukin 1 beta	Homo sapiens	61-69
31915516-4	2019	In an in vitro OA environment induced by interleukin-1 beta (IL-1beta), melatonin treatment improved cell proliferation of human chondrocytes, promoted the expression of cartilage ECM proteins (e.g., type II collagen and aggrecan), and inhibited the levels of IL-1beta-induced proteinases, such as matrix metalloproteinase 9 (MMP9), MMP13, ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4), and ADAMTS5.	Melatonin	72-81	interleukin 1 beta	Homo sapiens	260-268
31915516-5	2019	Both the microarray and polymerase chain reaction (PCR) experiments revealed that miR-140 was a melatonin-responsive microRNA and melatonin upregulated miR-140 expression, which was suppressed by IL-1beta stimulation.	Melatonin	96-105	interleukin 1 beta	Homo sapiens	196-204
31915516-5	2019	Both the microarray and polymerase chain reaction (PCR) experiments revealed that miR-140 was a melatonin-responsive microRNA and melatonin upregulated miR-140 expression, which was suppressed by IL-1beta stimulation.	Melatonin	130-139	interleukin 1 beta	Homo sapiens	196-204
31829277-15	2019	In human studies, dexmedetomidine reduced CRP (4 studies), TNFalpha (5 studies), IL-6 (6 studies), IL-1beta (3 studies), and altered several other mediators.	Dexmedetomidine	18-33	interleukin 1 beta	Homo sapiens	99-107
31811815-8	2019	In addition, nuclear translocation of NF-kappaB/p65 induced by IL-1beta in pericytes upregulated MMP-9 expression, which was inhibited by the NF-kappaB inhibitor PDTC.	prolinedithiocarbamate	162-166	interleukin 1 beta	Homo sapiens	63-71
31811815-11	2019	Melatonin reduced MMP-9 expression and activity, which was induced by IL-1beta through the regulation of the NOTCH3/NF-kappaB signaling pathway in pericytes, suggesting that pericytes regulate BBB integrity and function.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	70-78
31847340-0	2019	1,25(OH)2D3 Differently Affects Immunomodulatory Activities of Mesenchymal Stem Cells Depending on the Presence of TNF-alpha, IL-1beta and IFN-gamma.	25-hydroxyvitamin D3-bromoacetate	0-11	interleukin 1 beta	Homo sapiens	126-134
31847340-8	2019	With one exception, 1,25(OH)2D3 significantly reduced TNF-alpha-, IL-1beta-, and IFN-gamma-induced expression of all the investigated immunomediators in hPDLSCs, albeit to different extents.	25-hydroxyvitamin D3-bromoacetate	20-31	interleukin 1 beta	Homo sapiens	66-74
31836774-4	2019	However, these effects were prevented by the IRE1 endonuclease inhibitor STF083010 since it time-dependently reduced IL-1beta-induced Xbp1 mRNA splicing, XBP1s protein expression, inflammatory factor IL-6 secretion and the expression of the fibrotic marker fibronectin in human peritoneal mesothelial cells (HPMCs).	STF 083010	73-82	interleukin 1 beta	Homo sapiens	117-125
31849516-6	2019	After ALA-PDT, IL1r1 and IL1beta increased in patients" biopsies, principally in mesenchymal cells.	delta-aminolevulinic acid methyl ester	6-9	interleukin 1 beta	Homo sapiens	25-32
31822637-3	2019	Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta).	Nickel	27-32	interleukin 1 beta	Homo sapiens	281-298
31822637-3	2019	Here, we demonstrated that NiCl2 activated nuclear factor kappa B (NF-kappaB), mitogen-activated protein kinases (MAPKs) and interferon regulatory factor 3 (IRF3) signaling pathways in primary bone marrow-derived macrophages (BMDMs), leading to the altered transcription levels of interleukin-1beta (IL-1beta), -6, -8, -18, tumor necrosis factor-alpha (TNF-alpha) and interferon beta (INF-beta).	Nickel	27-32	interleukin 1 beta	Homo sapiens	300-308
31822637-4	2019	We also found that nickel chloride (NiCl2) activated Nod-like receptor 3 (NLRP3) inflammasome pathway, resulting in the proteolytic cleavage and release of IL-1beta.	nickel chloride	19-34	interleukin 1 beta	Homo sapiens	156-164
31822637-4	2019	We also found that nickel chloride (NiCl2) activated Nod-like receptor 3 (NLRP3) inflammasome pathway, resulting in the proteolytic cleavage and release of IL-1beta.	Nickel	36-41	interleukin 1 beta	Homo sapiens	156-164
31835494-5	2019	Moreover, the elevated expressions of c-Fos and phosphorylated c-Jun induced by interleukin-1beta (IL-1beta) were reversed by TCDCA.	Taurochenodeoxycholic Acid	126-131	interleukin 1 beta	Homo sapiens	80-97
31811815-5	2019	In this study, we observed that interleukin-1beta (IL-1beta)-induced MMP-9 secretion in pericytes increased BBB permeability to sodium fluorescein (Na-F) by damaging the disruption of VE-cadherin, occludin, claudin-5, and zonula occludin-1 (ZO-1).	Fluorescein	128-146	interleukin 1 beta	Homo sapiens	32-49
31811815-5	2019	In this study, we observed that interleukin-1beta (IL-1beta)-induced MMP-9 secretion in pericytes increased BBB permeability to sodium fluorescein (Na-F) by damaging the disruption of VE-cadherin, occludin, claudin-5, and zonula occludin-1 (ZO-1).	Fluorescein	128-146	interleukin 1 beta	Homo sapiens	51-59
31811815-5	2019	In this study, we observed that interleukin-1beta (IL-1beta)-induced MMP-9 secretion in pericytes increased BBB permeability to sodium fluorescein (Na-F) by damaging the disruption of VE-cadherin, occludin, claudin-5, and zonula occludin-1 (ZO-1).	Sodium	148-152	interleukin 1 beta	Homo sapiens	32-49
31811815-5	2019	In this study, we observed that interleukin-1beta (IL-1beta)-induced MMP-9 secretion in pericytes increased BBB permeability to sodium fluorescein (Na-F) by damaging the disruption of VE-cadherin, occludin, claudin-5, and zonula occludin-1 (ZO-1).	Sodium	148-152	interleukin 1 beta	Homo sapiens	51-59
31819645-13	2019	The levels of LDH, IL-1beta and IL-18 of matrine combined with docetaxel-treated DU145 and PC-3 cells were significantly increased, compared with the untreated control cells.	matrine	41-48	interleukin 1 beta	Homo sapiens	19-27
31826178-0	2019	Retraction notice for: "Ginsenoside Rd inhibits IL-1beta-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination" [Braz J Med Biol Res (2019) 52(9): e8525].	Ginsenosides	24-35	interleukin 1 beta	Homo sapiens	48-56
31826178-0	2019	Retraction notice for: "Ginsenoside Rd inhibits IL-1beta-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination" [Braz J Med Biol Res (2019) 52(9): e8525].	Rhenium	184-187	interleukin 1 beta	Homo sapiens	48-56
31885501-6	2019	Furthermore, fetal membrane and villous explants treated with LPS had higher tissue levels of sEH mRNA and protein and 14,15-DHET than those present in the vehicle controls, while the administration of AUDA in the media attenuated the LPS-induced production of 14,15-DHET in tissue homogenates and IL-1beta and IL-6 in the media of explant cultures.	12-(3-adamantan-1-ylureido)dodecanoic acid	202-206	interleukin 1 beta	Homo sapiens	298-306
31819645-13	2019	The levels of LDH, IL-1beta and IL-18 of matrine combined with docetaxel-treated DU145 and PC-3 cells were significantly increased, compared with the untreated control cells.	docetaxel	63-72	interleukin 1 beta	Homo sapiens	19-27
30945564-9	2019	Consequently, vildagliptin inhibits production of two cytokines that are favored by NLRP3 inflammasome machinery: IL-1beta and IL-18.	Vildagliptin	14-26	interleukin 1 beta	Homo sapiens	114-122
31787760-4	2019	Clodronate-mediated depletion of resident macrophages revealed expression of IL1B and IL10 mostly from macrophages, while IL6, TNF, and TGFB1 came largely from a non-macrophage origin in human islets.	Clodronic Acid	0-10	interleukin 1 beta	Homo sapiens	77-81
30942641-10	2019	Our results indicate that saxagliptin significantly inhibited LPS-induced expression and secretions of tumour necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in HDPCs.	saxagliptin	26-37	interleukin 1 beta	Homo sapiens	145-167
31106593-0	2019	Vascular protection of salicin on IL-1beta-induced endothelial inflammatory response and damages in retinal endothelial cells.	salicin	23-30	interleukin 1 beta	Homo sapiens	34-42
31106593-4	2019	Our data indicate that the presence of salicin in RECs culture media ameliorates interleukin-1beta (IL-1beta)-induced cellular reactive oxygen species (ROS) production and NADPH oxidase 4 (NOX-4) expression.	salicin	39-46	interleukin 1 beta	Homo sapiens	81-98
31146598-0	2019	Paeonol prevents IL-1beta-induced inflammatory response and degradation of type II collagen in human primary chondrocytes.	paeonol	0-7	interleukin 1 beta	Homo sapiens	17-25
31106593-4	2019	Our data indicate that the presence of salicin in RECs culture media ameliorates interleukin-1beta (IL-1beta)-induced cellular reactive oxygen species (ROS) production and NADPH oxidase 4 (NOX-4) expression.	salicin	39-46	interleukin 1 beta	Homo sapiens	100-108
31106593-4	2019	Our data indicate that the presence of salicin in RECs culture media ameliorates interleukin-1beta (IL-1beta)-induced cellular reactive oxygen species (ROS) production and NADPH oxidase 4 (NOX-4) expression.	Reactive Oxygen Species	127-150	interleukin 1 beta	Homo sapiens	81-98
31106593-4	2019	Our data indicate that the presence of salicin in RECs culture media ameliorates interleukin-1beta (IL-1beta)-induced cellular reactive oxygen species (ROS) production and NADPH oxidase 4 (NOX-4) expression.	Reactive Oxygen Species	127-150	interleukin 1 beta	Homo sapiens	100-108
31106593-4	2019	Our data indicate that the presence of salicin in RECs culture media ameliorates interleukin-1beta (IL-1beta)-induced cellular reactive oxygen species (ROS) production and NADPH oxidase 4 (NOX-4) expression.	Reactive Oxygen Species	152-155	interleukin 1 beta	Homo sapiens	81-98
31106593-4	2019	Our data indicate that the presence of salicin in RECs culture media ameliorates interleukin-1beta (IL-1beta)-induced cellular reactive oxygen species (ROS) production and NADPH oxidase 4 (NOX-4) expression.	Reactive Oxygen Species	152-155	interleukin 1 beta	Homo sapiens	100-108
31106593-5	2019	At the cellular level, salicin attenuates IL-1beta-induced mitochondrial injury as revealed by its preservation on mitochondrial membrane potential (MMP).	salicin	23-30	interleukin 1 beta	Homo sapiens	42-50
31106593-6	2019	Furthermore, salicin inhibits IL-1beta-induced production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), vascular adhesion molecules such as intercellular cell adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and high-mobility group protein 1 (HMGB-1).	salicin	13-20	interleukin 1 beta	Homo sapiens	30-38
31106593-7	2019	On the other hand, salicin recovers IL-1beta-induced reduction of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) release.	salicin	19-26	interleukin 1 beta	Homo sapiens	36-44
31106593-7	2019	On the other hand, salicin recovers IL-1beta-induced reduction of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) release.	Nitric Oxide	78-90	interleukin 1 beta	Homo sapiens	36-44
31106593-8	2019	The presence of salicin significantly reduces the IL-1beta-induced release of lactate dehydrogenase (LDH), indicating that it mitigates cytokine caused cytotoxicity.	salicin	16-23	interleukin 1 beta	Homo sapiens	50-58
31237151-0	2019	GPR39 agonist TC-G 1008 ameliorates IL-1beta-induced chondrocyte senescence.	GPR39-C3	14-23	interleukin 1 beta	Homo sapiens	36-44
31106593-9	2019	Mechanistically, we show that salicin suppresses IL-1beta-induced activation of the nuclear factor-kappa B (NF-kappaB) signaling as revealed by its suppression on nuclear p65 protein and transfected NF-kappaB promoter.	salicin	30-37	interleukin 1 beta	Homo sapiens	49-57
31237151-5	2019	The GPR39 agonist TC-G 1008 mitigates IL-1beta-induced chondrocyte senescence.	GPR39-C3	18-27	interleukin 1 beta	Homo sapiens	38-46
31237151-6	2019	Mechanistically, we show that TC-G 1008 mitigates IL-1beta-induced cell cycle arrest at G1 phase by suppressing the expression of p53, p21, PAI-1, and K382 acetylation of p53.	GPR39-C3	30-39	interleukin 1 beta	Homo sapiens	50-58
31284768-5	2019	Tofacitinib ameliorates oxidized low-density lipoprotein (ox-LDL)-induced adhesion of THP-1 cells to HAECs, suppresses the expression of vascular adhesion molecules and production of cytokines, including vascular cell adhesion molecule 1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	tofacitinib	0-11	interleukin 1 beta	Homo sapiens	341-358
31237151-7	2019	Moreover, we show that TC-G 1008 treatment restores IL-1beta-induced inhibition of SIRT1 and the silencing of SIRT1 abolishes the function of TC-G 1008 on p53 acetylation and senescence, suggesting that the function of GPR39 signaling is mediated by SIRT1 in chondrocytes.	GPR39-C3	23-32	interleukin 1 beta	Homo sapiens	52-60
31284768-5	2019	Tofacitinib ameliorates oxidized low-density lipoprotein (ox-LDL)-induced adhesion of THP-1 cells to HAECs, suppresses the expression of vascular adhesion molecules and production of cytokines, including vascular cell adhesion molecule 1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	tofacitinib	0-11	interleukin 1 beta	Homo sapiens	360-368
31468982-7	2019	The results showed that juglanin dose-dependently suppressed PGE2, NO, MMP-1, MMP3, MMP13, TNF-alpha and IL-6 production induced by IL-1beta.	juglanin	24-32	interleukin 1 beta	Homo sapiens	132-140
31468982-0	2019	Juglanin inhibits IL-1beta-induced inflammation in human chondrocytes.	juglanin	0-8	interleukin 1 beta	Homo sapiens	18-26
31468982-7	2019	The results showed that juglanin dose-dependently suppressed PGE2, NO, MMP-1, MMP3, MMP13, TNF-alpha and IL-6 production induced by IL-1beta.	Dinoprostone	61-65	interleukin 1 beta	Homo sapiens	132-140
31468982-8	2019	The expression of COX-2, iNOS, ADAMTS-4 and ADAMTS-5 induced by IL-1beta were also suppressed by juglanin pretreatment.	juglanin	97-105	interleukin 1 beta	Homo sapiens	64-72
31468982-9	2019	Western blot analysis showed that juglanin suppressed IL-1beta-induced NF-kappaB activation.	juglanin	34-42	interleukin 1 beta	Homo sapiens	54-62
31468982-10	2019	Taken together, we found that juglanin inhibits IL-1beta-induced inflammation through the regulation of NF-kappaB signalling.	juglanin	30-38	interleukin 1 beta	Homo sapiens	48-56
31514535-5	2019	We found that cilostazol significantly reduced NLRP3 inflammasome activation, as well as the activity of other related and harmful factors, including oxidative stress, expression of NADPH oxidase 4 (NOX-4), thioredoxin-interacting protein (TxNIP), high mobility group box 1 (HMGB-1), interleukin 1beta (IL-1beta) and IL-18.	Cilostazol	14-24	interleukin 1 beta	Homo sapiens	284-301
31400567-0	2019	An impedimetric molecularly-imprinted biosensor for Interleukin-1beta determination, prepared by in-situ electropolymerization on carbon screen-printed electrodes.	Carbon	130-136	interleukin 1 beta	Homo sapiens	52-69
31514535-5	2019	We found that cilostazol significantly reduced NLRP3 inflammasome activation, as well as the activity of other related and harmful factors, including oxidative stress, expression of NADPH oxidase 4 (NOX-4), thioredoxin-interacting protein (TxNIP), high mobility group box 1 (HMGB-1), interleukin 1beta (IL-1beta) and IL-18.	Cilostazol	14-24	interleukin 1 beta	Homo sapiens	303-311
31400567-1	2019	This work reports the first electrochemical molecularly imprinted polymer (MIP) sensor for Interleukin-1beta (IL-1beta) detection, based on modified commercial screen-printed carbon electrode (SPCE) was successfully demonstrated.	Carbon	175-181	interleukin 1 beta	Homo sapiens	91-108
31400567-1	2019	This work reports the first electrochemical molecularly imprinted polymer (MIP) sensor for Interleukin-1beta (IL-1beta) detection, based on modified commercial screen-printed carbon electrode (SPCE) was successfully demonstrated.	Carbon	175-181	interleukin 1 beta	Homo sapiens	110-118
31470141-0	2019	Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	interleukin 1 beta	Homo sapiens	105-122
31470141-0	2019	Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts.	ros	74-77	interleukin 1 beta	Homo sapiens	105-122
31392929-5	2019	Here, adenine was found to significantly inhibit the secretion of lipopolysaccharide-induced inflammatory cytokines such as TNF-alpha, IL-1beta and IL-6 in THP-1 cells.	Adenine	6-13	interleukin 1 beta	Homo sapiens	135-143
31470141-10	2019	CONCLUSION: Reversine inhibits IL-1beta-induced MMP and cytokine expression via inhibition of MAPK/AP-1 activation and ROS generation.	ros	119-122	interleukin 1 beta	Homo sapiens	31-39
31511637-0	2019	Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1beta transcription and processing in monocytes.	ros	72-75	interleukin 1 beta	Homo sapiens	91-99
31638409-3	2019	A high glucose concentration induced HRVEC inflammation metabolic memory by decreasing SIRT1 and increasing Ac-NF-kappaB, NLRP3, caspase 1, interleukin-1beta, inducible nitric oxide synthase, and tumor necrosis factor alpha, whereas exposure of HRVECs to a high glucose medium for 4 days, followed by a normal glucose concentration for an additional 4 days, failed to reverse these changes.	Glucose	7-14	interleukin 1 beta	Homo sapiens	140-157
31123968-6	2019	Accordingly, LPS-induced increases in IL-1beta and IL-6 mRNA and TNF-alpha release were significantly and synergistically diminished by cilostazol and celecoxib cotreatment.	Cilostazol	136-146	interleukin 1 beta	Homo sapiens	38-46
31570032-3	2019	We found that cardamonin treatment alleviates intestinal disease, including recurring colitis and colitis-associated tumorigenesis, along with the reduced secretion of IL-1beta and TNF-alpha.	cardamonin	14-24	interleukin 1 beta	Homo sapiens	168-176
31328322-7	2019	Importantly, we observed that treatment with SCH58261, a selective A2A R antagonist, restored the expression levels of several inflammatory and astrocytic activation-related genes, such as Interleukin-1beta and vimentin.	5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine	45-53	interleukin 1 beta	Homo sapiens	189-206
31764352-4	2019	QUESTIONS/PURPOSES: Using human OA knee chondrocytes in vitro, we asked, does chloramphenicol (1) activate autophagy in chondrocytes; (2) protect chondrocytes from IL-1beta-induced apoptosis; and (3) reduce the expression of matrix metallopeptidase (MMP)-13 and IL-6 (markers associated with articular cartilage degradation and joint inflammation).	Chloramphenicol	78-93	interleukin 1 beta	Homo sapiens	164-172
30877711-7	2019	Gemigliptin-treated kidneys showed a reduction in levels of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), caspase-1, and interleukin-1beta, which had all been markedly increased by UUO.	LC15-0444	0-11	interleukin 1 beta	Homo sapiens	169-186
31171434-3	2019	Antiinflammatory drugs that interfere with the IL-1beta pathway, such as anakinra, can control benzodiazepine-refractory status epilepticus in animals, and there is recent proof-of-concept evidence for therapeutic effects in children with Febrile infection related epilepsy syndrome (FIRES).	Benzodiazepines	95-109	interleukin 1 beta	Homo sapiens	47-55
31123968-6	2019	Accordingly, LPS-induced increases in IL-1beta and IL-6 mRNA and TNF-alpha release were significantly and synergistically diminished by cilostazol and celecoxib cotreatment.	Celecoxib	151-160	interleukin 1 beta	Homo sapiens	38-46
31123968-8	2019	Summarizing, cotreatment with cilostazol and celecoxib exhibited a synergistic increase in IL-10 production and SOCS3 expressions, thereby resulted in synergistic decreases in IL-1beta mRNA, IL-6 mRNA expression and TNF-alpha synthesis in association with synergistic decreases in COX-2 and PGE2 protein expression in the RA synovial fibroblasts.	Cilostazol	30-40	interleukin 1 beta	Homo sapiens	176-184
31123968-8	2019	Summarizing, cotreatment with cilostazol and celecoxib exhibited a synergistic increase in IL-10 production and SOCS3 expressions, thereby resulted in synergistic decreases in IL-1beta mRNA, IL-6 mRNA expression and TNF-alpha synthesis in association with synergistic decreases in COX-2 and PGE2 protein expression in the RA synovial fibroblasts.	Celecoxib	45-54	interleukin 1 beta	Homo sapiens	176-184
31485636-10	2019	It was also observed that curcumin treatment downregulated the expression levels of TXNIP, NLRP3, interleukin (IL)-1beta and IL-18, and downstream caspase-1 compared with PQ treatment alone.	Curcumin	26-34	interleukin 1 beta	Homo sapiens	98-120
31086288-0	2019	Forskolin attenuates the NLRP3 inflammasome activation and IL-1beta secretion in human macrophages.	Colforsin	0-9	interleukin 1 beta	Homo sapiens	59-67
31513788-6	2019	Intraparaventricular nucleus (iPVN) infusion of IL-1beta produced markedly anxiety-like behaviors and increased release of GABA from astrocytes.	gamma-Aminobutyric Acid	123-127	interleukin 1 beta	Homo sapiens	48-56
31513788-8	2019	Treatment of L-AAA or NPPB decreased IL-1beta-induced gliotransmitter GABA release measured by in vivo microdialysis.	gamma-Aminobutyric Acid	70-74	interleukin 1 beta	Homo sapiens	37-45
31086288-2	2019	Here we studied whether cyclic adenosine monophosphate (cAMP) elevator forskolin could attenuate the nigericin-induced NLRP3-inflammasome activation and interleukin-1beta (IL-1beta) secretion in human macrophages.	Cyclic AMP	24-54	interleukin 1 beta	Homo sapiens	153-170
31086288-7	2019	Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P &lt; 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P &lt; 0.01).	Nigericin	75-84	interleukin 1 beta	Homo sapiens	6-14
31086288-7	2019	Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P &lt; 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P &lt; 0.01).	Colforsin	108-117	interleukin 1 beta	Homo sapiens	6-14
31434103-0	2019	Insights image for Forskolin attenuates the NLRP3 inflammasome activation and IL-1beta secretion in human macrophages.	Colforsin	19-28	interleukin 1 beta	Homo sapiens	78-86
31086288-2	2019	Here we studied whether cyclic adenosine monophosphate (cAMP) elevator forskolin could attenuate the nigericin-induced NLRP3-inflammasome activation and interleukin-1beta (IL-1beta) secretion in human macrophages.	Cyclic AMP	24-54	interleukin 1 beta	Homo sapiens	172-180
31086288-7	2019	Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P &lt; 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P &lt; 0.01).	Colforsin	108-117	interleukin 1 beta	Homo sapiens	185-193
31086288-2	2019	Here we studied whether cyclic adenosine monophosphate (cAMP) elevator forskolin could attenuate the nigericin-induced NLRP3-inflammasome activation and interleukin-1beta (IL-1beta) secretion in human macrophages.	Cyclic AMP	56-60	interleukin 1 beta	Homo sapiens	153-170
31086288-7	2019	Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P &lt; 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P &lt; 0.01).	Nigericin	147-156	interleukin 1 beta	Homo sapiens	6-14
31086288-7	2019	Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P &lt; 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P &lt; 0.01).	Nigericin	147-156	interleukin 1 beta	Homo sapiens	185-193
31086288-2	2019	Here we studied whether cyclic adenosine monophosphate (cAMP) elevator forskolin could attenuate the nigericin-induced NLRP3-inflammasome activation and interleukin-1beta (IL-1beta) secretion in human macrophages.	Colforsin	71-80	interleukin 1 beta	Homo sapiens	153-170
31086288-8	2019	Forskolin also inhibited the IL-1beta secretion from activated human primary macrophages.	Colforsin	0-9	interleukin 1 beta	Homo sapiens	29-37
31086288-9	2019	CONCLUSIONS: Forskolin inhibits the NLRP3 inflammasome activation and the secretion of mature IL-1beta, in human macrophages.	Colforsin	13-22	interleukin 1 beta	Homo sapiens	94-102
31086288-4	2019	RESULTS: Activation of THP-1 macrophages with nigericin increased the mRNA expression of NLRP3, IL-1beta, and caspase-1 (P &lt; 0.01).	Nigericin	46-55	interleukin 1 beta	Homo sapiens	96-104
31775905-0	2019	Hydroxychloroquine inhibits IL-1beta production from amyloid-stimulated human neutrophils.	Hydroxychloroquine	0-18	interleukin 1 beta	Homo sapiens	28-36
30773096-0	2019	Lipoxin A4 Suppresses IL-1beta-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis.	lipoxin A4	0-10	interleukin 1 beta	Homo sapiens	22-30
30773096-5	2019	Lipoxin A4 efficiently suppressed IL-1beta-induced COX-2 protein expression in ectopic endometriotic stromal cells (ESCs) via its receptor, formyl peptide receptor 2/lipoxin A4 receptor (FPR2/ALX).	lipoxin A4	0-10	interleukin 1 beta	Homo sapiens	34-42
30773096-8	2019	Pretreatment of ESCs with LXA4 inhibited the phosphorylation of p38 MAPK induced by IL-1beta.	lipoxin A4	26-30	interleukin 1 beta	Homo sapiens	84-92
31658511-3	2019	Methods and Results: In this study, we found that the PVC secretome effectively alleviates secretion of both caspase-1 and interleukin-1beta in lipopolysaccharide-primed and activated human and murine macrophages by blocking inflammasome activation and attenuating the production of mitochondrial reactive oxygen species (ROS).	Oxygen	306-312	interleukin 1 beta	Homo sapiens	123-140
31775905-7	2019	HCQ pretreatment significantly inhibited the SAA-induced IL-1beta production in human neutrophils, but did not affect the SAA-induced NF-kappaB activation, pro-IL-1beta mRNA expression, and NLRP3 protein expression.	Hydroxychloroquine	0-3	interleukin 1 beta	Homo sapiens	57-65
31775905-9	2019	CONCLUSIONS: Treatment with HCQ was associated with impaired production of IL-1beta in SAA-stimulated human neutrophils without affecting the priming process of the NLRP3 inflammasome such as pro-IL-1beta or NLRP3 induction.	Hydroxychloroquine	28-31	interleukin 1 beta	Homo sapiens	75-83
31775905-9	2019	CONCLUSIONS: Treatment with HCQ was associated with impaired production of IL-1beta in SAA-stimulated human neutrophils without affecting the priming process of the NLRP3 inflammasome such as pro-IL-1beta or NLRP3 induction.	Hydroxychloroquine	28-31	interleukin 1 beta	Homo sapiens	196-204
31775905-10	2019	These findings suggest that HCQ affects the NLRP3 activation process, resulting in the impaired IL-1beta production in human neutrophils, as representative innate immune cells.	Hydroxychloroquine	28-31	interleukin 1 beta	Homo sapiens	96-104
31779275-6	2019	Transcriptional profiling revealed that various genes coding for cytokines and other proinflammatory proteins were upregulated upon recombinant alpha-MMC treatment in THP-1 cells, including MCP-1, IL-8, IL-1beta, and TNF-alpha.	MK 316	144-153	interleukin 1 beta	Homo sapiens	203-211
31772145-0	2019	Melatonin modulates IL-1beta-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	20-28
31772145-4	2019	In the present study, we treated human nucleus pulposus cells (NPCs) with melatonin and discovered that melatonin could modulate extracellular matrix (ECM) remodeling induced by IL-1beta by enhancing collagen II and aggrecan expression levels and by downregulating matrix metalloproteinase-3 (MMP-3) levels.	Melatonin	104-113	interleukin 1 beta	Homo sapiens	178-186
31766412-11	2019	Nevertheless, while TiO2 and CeO2 were non-cytotoxic in any conditions, differences in cytotoxicity, NO, and IL-1beta releases were found for the SiO2, depending upon the protocol.	Silicon	146-150	interleukin 1 beta	Homo sapiens	109-117
31819369-0	2019	Icariin Alleviates IL-1beta-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes.	icariin	0-7	interleukin 1 beta	Homo sapiens	19-27
31819369-2	2019	This study aimed to investigate the potential antioxidative and chondroprotective effects and underlying mechanism of Icariin (ICA) in interleukin-1 beta (IL-1beta)-induced extracellular matrix (ECM) degradation of OA cartilage.	icariin	118-125	interleukin 1 beta	Homo sapiens	135-153
31819369-2	2019	This study aimed to investigate the potential antioxidative and chondroprotective effects and underlying mechanism of Icariin (ICA) in interleukin-1 beta (IL-1beta)-induced extracellular matrix (ECM) degradation of OA cartilage.	icariin	118-125	interleukin 1 beta	Homo sapiens	155-163
31819369-2	2019	This study aimed to investigate the potential antioxidative and chondroprotective effects and underlying mechanism of Icariin (ICA) in interleukin-1 beta (IL-1beta)-induced extracellular matrix (ECM) degradation of OA cartilage.	icariin	127-130	interleukin 1 beta	Homo sapiens	135-153
31819369-2	2019	This study aimed to investigate the potential antioxidative and chondroprotective effects and underlying mechanism of Icariin (ICA) in interleukin-1 beta (IL-1beta)-induced extracellular matrix (ECM) degradation of OA cartilage.	icariin	127-130	interleukin 1 beta	Homo sapiens	155-163
31819369-8	2019	ROS induced by IL-1beta could drastically activate matrix-degrading proteases and ICA could significantly rescue the matrix degradation and excess ROS generation caused by IL-1beta.	icariin	82-85	interleukin 1 beta	Homo sapiens	172-180
31754153-1	2019	The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome mediates caspase-1 activation and IL-1beta processing and is implicated in autoinflammatory as well as other chronic inflammatory diseases.	MRT67307	68-73	interleukin 1 beta	Homo sapiens	149-157
31819369-10	2019	Ablation of Nrf2 abrogated the chondroprotective and antioxidative effects of ICA in IL-1beta-treated chondrocytes.	icariin	78-81	interleukin 1 beta	Homo sapiens	85-93
31819369-11	2019	Conclusion: ICA alleviates IL-1beta-induced matrix degradation and eliminates ROS by activating the Nrf2/ARE pathway.	icariin	12-15	interleukin 1 beta	Homo sapiens	27-35
31754153-3	2019	In this study, we report that febuxostat, an inhibitor of XOR, suppressed NLRP3 inflammasome-mediated IL-1beta secretion and cell death by two mechanisms: in a mitochondrial ROS (mitoROS)-dependent and mitoROS-independent manner.	febuxostat	30-40	interleukin 1 beta	Homo sapiens	102-110
31738650-5	2021	When these LPS + LBP-stimulated cells were exposed to DHT for 2 days, it was found that DHT suppressed the secretion of IL-6, IL-10, IL-1beta, VEGF-A cytokines in corneal epithelial cells; TNF-alpha, IL-6, IL-1beta, VEGF-A cytokines in conjunctival epithelial cells; and IL-6, IL-1beta, VEGF-A cytokines in meibomian gland epithelial cells.Conclusion: LPS + LBP is shown to induce the secretion of certain proinflammatory cytokines from ocular surface and adnexal epithelial cells.	Dihydrotestosterone	88-91	interleukin 1 beta	Homo sapiens	206-214
31824305-12	2019	CHC and HC dose-dependently reduced IL-1beta and CCL2 messenger RNA (mRNA) expression.	cyclohexyl 4'-O-cyclohexylcellobiose	0-3	interleukin 1 beta	Homo sapiens	36-44
31824305-12	2019	CHC and HC dose-dependently reduced IL-1beta and CCL2 messenger RNA (mRNA) expression.	n-hexyl beta-D-glucopyranoside	1-3	interleukin 1 beta	Homo sapiens	36-44
31824305-15	2019	2-HEC, 2-HPC, and GCBD dose-dependently inhibited LPS-induced IL-1beta, TNF-alpha, and IL-6 synthesis.	glycol monoacetate	0-5	interleukin 1 beta	Homo sapiens	62-70
31824305-15	2019	2-HEC, 2-HPC, and GCBD dose-dependently inhibited LPS-induced IL-1beta, TNF-alpha, and IL-6 synthesis.	2-(1-hydroxypentyl)-benzoate	7-12	interleukin 1 beta	Homo sapiens	62-70
31738650-5	2021	When these LPS + LBP-stimulated cells were exposed to DHT for 2 days, it was found that DHT suppressed the secretion of IL-6, IL-10, IL-1beta, VEGF-A cytokines in corneal epithelial cells; TNF-alpha, IL-6, IL-1beta, VEGF-A cytokines in conjunctival epithelial cells; and IL-6, IL-1beta, VEGF-A cytokines in meibomian gland epithelial cells.Conclusion: LPS + LBP is shown to induce the secretion of certain proinflammatory cytokines from ocular surface and adnexal epithelial cells.	Dihydrotestosterone	88-91	interleukin 1 beta	Homo sapiens	133-141
31738650-5	2021	When these LPS + LBP-stimulated cells were exposed to DHT for 2 days, it was found that DHT suppressed the secretion of IL-6, IL-10, IL-1beta, VEGF-A cytokines in corneal epithelial cells; TNF-alpha, IL-6, IL-1beta, VEGF-A cytokines in conjunctival epithelial cells; and IL-6, IL-1beta, VEGF-A cytokines in meibomian gland epithelial cells.Conclusion: LPS + LBP is shown to induce the secretion of certain proinflammatory cytokines from ocular surface and adnexal epithelial cells.	Dihydrotestosterone	88-91	interleukin 1 beta	Homo sapiens	206-214
31703439-6	2019	RES and PD strongly inhibited IL-1beta induced by crystals after cell pretreatment.	4-phosphoerythronohydroxamic acid	0-3	interleukin 1 beta	Homo sapiens	30-38
31735077-9	2021	Meanwhile, silencing LINC01534 also significantly inhibited the productions of proinflammatory factors NO, PGE2, TNF-alpha, IL-6, and IL-8 in the IL-1beta-induced chondrocytes.	Dinoprostone	107-111	interleukin 1 beta	Homo sapiens	146-154
31591147-5	2019	BP-1-102 treatment alleviated renal interstitial fibrosis, reduced collagen deposition and extracellular matrix protein production, inhibited inflammatory cell infiltration, suppressed the percentage of CD45+ PDGFRbeta+, CD45+ CD34- Col I+ and CD45+ CD11b+ Col I+ cells within the obstructed kidney and reduced the mRNA levels of the proinflammatory and profibrotic cytokines IL-1beta, TGF-beta, TNF-alpha, ICAM-1, and CXCL16.	BP-1-102	0-8	interleukin 1 beta	Homo sapiens	376-384
31827916-9	2019	Further results indicated that MMC can inhibit the activation of the NLRP3 inflammatory signalling pathway and thus downregulate the expression of downstream molecules, including IL-18 and IL-1beta.	Mitomycin	31-34	interleukin 1 beta	Homo sapiens	189-197
31921558-6	2020	Mechanistically, IL1R2 is activated by IL1beta, as demonstrated by the fact that IL1beta induces the release of IL1R2 intracellular domain (icd-IL1R2) and icd-IL1R2 then interacts with the deubiquitinase USP15 at the UBL2 domain and promotes its activity, which finally induces BMI1 deubiquitination at lysine 81 and stabilizes BMI1 protein.	tyrosyl-lysine	303-309	interleukin 1 beta	Homo sapiens	39-46
31921558-6	2020	Mechanistically, IL1R2 is activated by IL1beta, as demonstrated by the fact that IL1beta induces the release of IL1R2 intracellular domain (icd-IL1R2) and icd-IL1R2 then interacts with the deubiquitinase USP15 at the UBL2 domain and promotes its activity, which finally induces BMI1 deubiquitination at lysine 81 and stabilizes BMI1 protein.	tyrosyl-lysine	303-309	interleukin 1 beta	Homo sapiens	81-88
31787969-5	2019	CD3+TCRalphabeta+ macrophages secrete IL-1beta, IL-6 IP-10, and MCP-1 by both tmTNF- and CD3-dependent pathways, while CD3+TCRalphabeta- macrophages specifically produce IFN-gamma, TNF, and MIP-1beta by a CD3-dependent pathway.	hepta-6-sulfato-beta-cyclodextrin	0-16	interleukin 1 beta	Homo sapiens	38-46
31703439-6	2019	RES and PD strongly inhibited IL-1beta induced by crystals after cell pretreatment.	polydatin	8-10	interleukin 1 beta	Homo sapiens	30-38
31930074-9	2019	Antifungal treatment could decrease the level of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha and interferon-gamma in CTG than in CNTG (P<0.05, respectively).	ctg	135-138	interleukin 1 beta	Homo sapiens	49-66
31521245-7	2019	Additionally, we also observed that N-Acetylcysteine (NAC, a ROS scavenger) pretreatment inhibited NLRP3 inflammasome activation as evidenced by suppressing the upregulation of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-1beta and IL-18 protein levels in CSE-treated ECs.	Acetylcysteine	36-52	interleukin 1 beta	Homo sapiens	217-225
31521245-7	2019	Additionally, we also observed that N-Acetylcysteine (NAC, a ROS scavenger) pretreatment inhibited NLRP3 inflammasome activation as evidenced by suppressing the upregulation of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-1beta and IL-18 protein levels in CSE-treated ECs.	Acetylcysteine	54-57	interleukin 1 beta	Homo sapiens	217-225
31592908-4	2019	The normal human chondrocyte pre-treated with rapamycin or 3-methyladenine, treated with interleukin-1beta (IL-1beta).	Sirolimus	46-55	interleukin 1 beta	Homo sapiens	89-106
31592908-4	2019	The normal human chondrocyte pre-treated with rapamycin or 3-methyladenine, treated with interleukin-1beta (IL-1beta).	Sirolimus	46-55	interleukin 1 beta	Homo sapiens	108-116
31592908-4	2019	The normal human chondrocyte pre-treated with rapamycin or 3-methyladenine, treated with interleukin-1beta (IL-1beta).	3-methyladenine	59-74	interleukin 1 beta	Homo sapiens	89-106
31592908-4	2019	The normal human chondrocyte pre-treated with rapamycin or 3-methyladenine, treated with interleukin-1beta (IL-1beta).	3-methyladenine	59-74	interleukin 1 beta	Homo sapiens	108-116
31684176-9	2019	Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis.	Eugenol	0-7	interleukin 1 beta	Homo sapiens	198-216
31684176-9	2019	Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis.	Eugenol	0-7	interleukin 1 beta	Homo sapiens	218-226
31332667-9	2019	However, production of IL-1beta, NO/iNOS as well as caspase-1/NLRP3 activity was significantly reduced in the presence of CRID3.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	122-127	interleukin 1 beta	Homo sapiens	23-31
31545873-6	2019	In addition, in serum and brain tissue, GA also dramatically inhibited the secretion of inflammatory cytokines, including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha.	Glycyrrhizic Acid	40-42	interleukin 1 beta	Homo sapiens	122-139
31545873-6	2019	In addition, in serum and brain tissue, GA also dramatically inhibited the secretion of inflammatory cytokines, including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha.	Glycyrrhizic Acid	40-42	interleukin 1 beta	Homo sapiens	141-149
31466050-10	2019	Moreover, genipin pretreatment alleviated LPS-induced inflammation, indicating by blockade of nuclear factor kappa b (NF-kappaB) signaling activation and reduced tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 levels in the lung and bronchoalveolar lavage fluid.	genipin	10-17	interleukin 1 beta	Homo sapiens	203-225
31994643-2	2019	Objective: The present study aimed to compare the efficacy of naproxen patches in pain control during orthodontic tooth separation, by means of visual analogue scale (VAS) and interleukin 1beta (IL-1beta) levels in gingival crevicular fluid (GCF).	Naproxen	62-70	interleukin 1 beta	Homo sapiens	176-193
31476693-8	2019	RESULT: We found that ELS significantly increased protein and mRNA levels and secretion of inflammatory factors IL-1beta and TNF-alpha, which Eupatilin attenuated through the Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) pathway.	N-[(2S,3S,4R)-3,4-dihydroxy-8-oxo-8-[(4-pentylphenyl)amino]-1-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octan-2-yl]hexacosanamide	22-25	interleukin 1 beta	Homo sapiens	112-120
31432628-2	2019	The nod-like receptor pyrin domain containing-3 (NLRP3) inflammasome is a metabolic sensor activated by saturated fatty acids (SFA) initiating IL-1beta inflammation and IR.	Fatty Acids	104-125	interleukin 1 beta	Homo sapiens	143-151
31795608-7	2019	PDRN treatment reduced TNF-alpha, IL-1beta, and IL-6 expression in POCD conditions, and significantly increased cAMP concentrations and the p-CREB/CREB ratio.	Polydeoxyribonucleotides	0-4	interleukin 1 beta	Homo sapiens	34-42
31445005-5	2019	METHODS AND RESULTS: In vitro and in vivo experiments showed that DOX treatment induced cardiomyocyte pyroptosis as evidenced by increased cell death and upregulated expression levels of NLR family pyrin domain containing 3 (NLRP3), caspase-3, IL-1beta, IL-18 and GMDSD-N.	Doxorubicin	66-69	interleukin 1 beta	Homo sapiens	244-252
31409628-4	2019	We show that bortezomib-exposed proinflammatory macrophages promote an enrichment of MM-tumor-initiating cells (MM-TIC) both in vitro and in vivo These effects are regulated in part by IL1beta, as blocking the IL1beta axis by a pharmacologic or genetic approach abolishes bortezomib-induced MM-TIC enrichment.	Bortezomib	13-23	interleukin 1 beta	Homo sapiens	185-192
31409628-4	2019	We show that bortezomib-exposed proinflammatory macrophages promote an enrichment of MM-tumor-initiating cells (MM-TIC) both in vitro and in vivo These effects are regulated in part by IL1beta, as blocking the IL1beta axis by a pharmacologic or genetic approach abolishes bortezomib-induced MM-TIC enrichment.	Bortezomib	13-23	interleukin 1 beta	Homo sapiens	210-217
31409628-4	2019	We show that bortezomib-exposed proinflammatory macrophages promote an enrichment of MM-tumor-initiating cells (MM-TIC) both in vitro and in vivo These effects are regulated in part by IL1beta, as blocking the IL1beta axis by a pharmacologic or genetic approach abolishes bortezomib-induced MM-TIC enrichment.	Bortezomib	272-282	interleukin 1 beta	Homo sapiens	185-192
31573051-13	2019	In addition, the results demonstrated that IL-21 treatment reduced the expression levels of proteins associated with the Wnt/beta-catenin signaling, whereas activation of Wnt/beta-catenin signaling with the LiCl agonist upregulated PD-L1, IL-1beta and TNF-alpha expression.	Lithium Chloride	207-211	interleukin 1 beta	Homo sapiens	239-247
31439713-9	2019	Furthermore, inflammatory cytokines (IL-8, IL-1beta and IL-11) were also up-regulated upon treatment with HCC approved kinase inhibitors Sorafenib and Regorafenib.	Sorafenib	137-146	interleukin 1 beta	Homo sapiens	43-51
31439713-9	2019	Furthermore, inflammatory cytokines (IL-8, IL-1beta and IL-11) were also up-regulated upon treatment with HCC approved kinase inhibitors Sorafenib and Regorafenib.	regorafenib	151-162	interleukin 1 beta	Homo sapiens	43-51
31593741-9	2019	Kidney TWEAK, IL-18, IL-1beta, TNF-alpha, NF-kappaB, Caspase 3 and Bax contents significantly decreased upon nilotinib administration while, kidney contents of Bcl2 and HSP-70 significantly increased.	nilotinib	109-118	interleukin 1 beta	Homo sapiens	21-29
31543273-7	2019	RESULTS: Lipopolysaccharides elicited the production of proinflammatory cytokines interleukin 1 beta and tumor necrosis factor alpha by macrophages, but this was suppressed by ciprofloxacin and metronidazole.	Metronidazole	194-207	interleukin 1 beta	Homo sapiens	82-132
31553934-7	2019	CBDV attenuates, in a TRPA1-antagonist sensitive manner, DNBS-induced signs of inflammation including neutrophil infiltration, intestinal permeability, and cytokine (i.e. IL-1beta, IL-6 and the chemokine MCP-1) production.	cannabidivarin	0-4	interleukin 1 beta	Homo sapiens	171-179
31736956-5	2019	The accumulated ATP promoted intracellular calcium accumulation and IL-1beta production in BMDCs through P2X7 signaling activation.	Adenosine Triphosphate	16-19	interleukin 1 beta	Homo sapiens	68-76
31671764-5	2019	Our results revealed that stybenpropol A reduced soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta) expression by ELISA, inhibited apoptosis, and accelerated nitric oxide (NO) release in TNF-alpha-treated HUVECs.	stybenpropol a	26-40	interleukin 1 beta	Homo sapiens	186-203
31652453-10	2019	NLRP3 inflammatory body and TXNIP were activated by ketamine, which was supported by the changes in TNF-alpha, IL-6, IL-1 and IL-18 in vivo and in vitro.	Ketamine	52-60	interleukin 1 beta	Homo sapiens	117-121
31652822-5	2019	Statins are largely prescribed to patients with myocardial infarction and diabetes, but their effects on IL-1beta synthesis and release remain to be fully characterized.	Simvastatin	0-7	interleukin 1 beta	Homo sapiens	105-113
31652822-6	2019	Of interest, preliminary studies even report IL-1beta secretion to rise after treatment with statins, with a potential impact on the inflammatory microenvironment and glycemic control.	Simvastatin	93-100	interleukin 1 beta	Homo sapiens	45-53
31652822-8	2019	In accordance with the dual lipid-lowering and anti-inflammatory effect of these drugs and in light of the important results achieved by IL-1beta inhibition through canakinumab in CV secondary prevention, we will dissect the current evidence linking statins with IL-1beta and outline the possible benefits of a potential double treatment with statins and canakinumab.	Simvastatin	250-257	interleukin 1 beta	Homo sapiens	137-145
31652822-8	2019	In accordance with the dual lipid-lowering and anti-inflammatory effect of these drugs and in light of the important results achieved by IL-1beta inhibition through canakinumab in CV secondary prevention, we will dissect the current evidence linking statins with IL-1beta and outline the possible benefits of a potential double treatment with statins and canakinumab.	Simvastatin	250-257	interleukin 1 beta	Homo sapiens	263-271
31639165-9	2019	Glycerol also induced the high expression of proinflammatory cytokine IL-1beta and IL-6 in kidney and human renal proximal tubule HK-2 cells.	Glycerol	0-8	interleukin 1 beta	Homo sapiens	70-78
31591201-6	2019	Pretreatment of cultured human microglia from normal adult brains with human recombinant IL-37 (1 to 100 ng/mL) inhibits neurotensin (NT)-stimulated secretion and gene expression of IL-1beta and CXCL8.	Neurotensin	121-132	interleukin 1 beta	Homo sapiens	182-190
31695615-9	2019	The plasma levels of IL-1beta, IL-6, TNF-alpha, HMGB1, and netrin-1 were significantly reduced with the treatment of minocycline.	Minocycline	117-128	interleukin 1 beta	Homo sapiens	21-29
31591201-6	2019	Pretreatment of cultured human microglia from normal adult brains with human recombinant IL-37 (1 to 100 ng/mL) inhibits neurotensin (NT)-stimulated secretion and gene expression of IL-1beta and CXCL8.	Neurotensin	134-136	interleukin 1 beta	Homo sapiens	182-190
31597739-1	2019	NLRC4 [nucleotide-binding domain and leucine-rich repeat (NLR) family, caspase recruitment domain (CARD) containing 4] is an innate immune receptor, which, upon detection of certain pathogens or internal distress signals, initiates caspase-1-mediated interleukin-1beta maturation and an inflammatory response.	Leucine	37-44	interleukin 1 beta	Homo sapiens	251-268
31635261-6	2019	In cellular models for oxidative stress, HME counteracted membrane lipid oxidation of human erythrocytes stimulated by tert-butyl hydroperoxide and prevented the generation of reactive oxygen species, as well as the GSH decay in IL-1beta-activated intestinal normal-like cells.	tert-Butylhydroperoxide	119-143	interleukin 1 beta	Homo sapiens	229-237
31635261-6	2019	In cellular models for oxidative stress, HME counteracted membrane lipid oxidation of human erythrocytes stimulated by tert-butyl hydroperoxide and prevented the generation of reactive oxygen species, as well as the GSH decay in IL-1beta-activated intestinal normal-like cells.	Glutathione	216-219	interleukin 1 beta	Homo sapiens	229-237
31449398-5	2019	THP-1-derived macrophages were used to study short-term anti-inflammatory activity (time scale 48 h), showing that PEM that contained heparin reduced cell adhesion and IL1-beta secretion, when compared to those with polystyrenesulfonate, used as alternative polyanion in multilayer formation.	Heparin	134-141	interleukin 1 beta	Homo sapiens	168-176
31737212-9	2019	Moreover, the expression levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were reduced in MPP+-induced SH-SY5Y cells.	1-(4-methoxyphenyl)pyridinium	124-128	interleukin 1 beta	Homo sapiens	79-96
31737212-9	2019	Moreover, the expression levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were reduced in MPP+-induced SH-SY5Y cells.	1-(4-methoxyphenyl)pyridinium	124-128	interleukin 1 beta	Homo sapiens	98-106
31686786-0	2019	Tanshinone I Inhibits IL-1beta-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis.	tanshinone	0-12	interleukin 1 beta	Homo sapiens	22-30
31686786-13	2019	Tanshinone I significantly inhibited IL-1beta-induced apoptosis in CHON-001 cells.	tanshinone	0-12	interleukin 1 beta	Homo sapiens	37-45
31686786-14	2019	In addition, the IL-1beta-induced collagen II, aggrecan degradation, SOX11 downregulation, and MMP-13 and p-NF-kappaB upregulation in CHON-001 cells were notably reversed by Tanshinone I treatment.	tanshinone	174-186	interleukin 1 beta	Homo sapiens	17-25
31594856-5	2019	However, high amounts of PGE2 and the proinflammatory cytokines IL-1beta and IL-6 were secreted by monocytes activated with MDP in the presence of conditioned medium obtained from CD3 bead-isolated T cells (Tc CM) but not from those isolated without CD3 beads.	Acetylmuramyl-Alanyl-Isoglutamine	124-127	interleukin 1 beta	Homo sapiens	64-72
31680871-5	2019	This enhanced channel activity occurred by a mechanism involving a microglia-dependent production of IL-1beta/TNF-alpha and the stimulation of p38 MAP kinase/iNOS/[Ca2+]i-mediated signaling and purinergic/glutamatergic pathways.	Calcium	164-168	interleukin 1 beta	Homo sapiens	101-109
31594856-5	2019	However, high amounts of PGE2 and the proinflammatory cytokines IL-1beta and IL-6 were secreted by monocytes activated with MDP in the presence of conditioned medium obtained from CD3 bead-isolated T cells (Tc CM) but not from those isolated without CD3 beads.	Contrast Media	207-212	interleukin 1 beta	Homo sapiens	64-72
31505164-11	2019	E804 was very potent in suppressing many pro-inflammatory genes, including il1a, il1b, il12a, ptgs2, tlr4, and others.	CHEMBL1276317	0-4	interleukin 1 beta	Homo sapiens	81-85
31314571-5	2019	We have reported that one such pioneer bacterium - Bacteroides fragilis (B. fragilis) and its surface component polysaccharide A (PSA) inhibit IL-1beta-induced inflammation in human primary fetal small intestinal cell line (H4 cells).	polysaccharide a	112-128	interleukin 1 beta	Homo sapiens	143-151
31468690-4	2019	CTH promotes NF-kappaB nuclear translocation through H2 S-mediated sulfhydration on cysteine-38 of the NF-kappaB p65 subunit, resulting in increased IL-1beta expression and H2 S-induced cell invasion.	Hydrogen	53-55	interleukin 1 beta	Homo sapiens	149-157
31468690-4	2019	CTH promotes NF-kappaB nuclear translocation through H2 S-mediated sulfhydration on cysteine-38 of the NF-kappaB p65 subunit, resulting in increased IL-1beta expression and H2 S-induced cell invasion.	Cysteine	84-92	interleukin 1 beta	Homo sapiens	149-157
31468690-4	2019	CTH promotes NF-kappaB nuclear translocation through H2 S-mediated sulfhydration on cysteine-38 of the NF-kappaB p65 subunit, resulting in increased IL-1beta expression and H2 S-induced cell invasion.	Hydrogen Sulfide	53-57	interleukin 1 beta	Homo sapiens	149-157
31468690-6	2019	Together, our findings provide evidence that CTH generated H2 S promotes prostate cancer progression and metastasis through IL-1beta/NF-kappaB signaling pathways.	Hydrogen	59-61	interleukin 1 beta	Homo sapiens	124-132
31586128-4	2019	VU0155069 strongly enhances survival rate in cecal ligation and puncture (CLP)-induced sepsis by inhibiting lung inflammation, leukocyte apoptosis, and the production of proinflammatory cytokines, especially IL-1beta.	N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide	0-9	interleukin 1 beta	Homo sapiens	208-216
31586128-5	2019	VU0155069 also significantly blocked IL-1beta production, caspase-1 activation, and pyroptosis caused by several inflammasome-activating signals in the bone marrow-derived macrophages (BMDMs).	N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide	0-9	interleukin 1 beta	Homo sapiens	37-45
31302424-3	2019	Nucleotide-binding domain and leucine-rich-repeat-containing family pyrin 3 (NLRP3) inflammasome as a multi-protein complex that activates caspase-1 can give rise to the proinflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 beta (IL-1beta) maturation.	Leucine	30-37	interleukin 1 beta	Homo sapiens	231-249
31548177-7	2019	Moreover, western blotting showed decreased expression of MMP9 and MMP13 in IL-1beta-induced chondrocytes after co-culture with ACY-1215-stimulated osteoblasts.	ricolinostat	128-136	interleukin 1 beta	Homo sapiens	76-84
31572532-11	2019	ASI also decreased the levels of the pro-inflammatory factors MPO, TNF-alpha, IL-1beta, IL-6 and NO, and upregulated the expression of claudin-1 and ZO-1 in colon tissues.	astragaloside A	0-3	interleukin 1 beta	Homo sapiens	78-86
31324698-7	2019	We found that increased caspase-1 activity and production of interleukin-1beta by THP-1 cells were caused by the supernatant from the incubation of carbamazepine with FLC-4 cells.	Carbamazepine	148-161	interleukin 1 beta	Homo sapiens	61-78
31572532-8	2019	The results indicated that lipopolysaccharide (LPS) significantly increased the pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6 in CCD-18Co cells, which was markedly ameliorated by ASI.	astragaloside A	189-192	interleukin 1 beta	Homo sapiens	118-126
31325727-9	2019	RESULTS: Myricetin not only inhibited the generation of inflammatory mediators and cytokines such as nitric oxide (NO), prostaglandin E2 (PGE2), TNF-alpha and IL-6, but also suppressed the production of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in human chondrocytes under IL-1beta stimulation.	myricetin	9-18	interleukin 1 beta	Homo sapiens	299-307
31306979-10	2019	Thus, eupatilin can inhibit IL-1beta-induced apoptosis via sestrin2-dependent autophagy in chondrocytes.	eupatilin	6-15	interleukin 1 beta	Homo sapiens	28-36
31313075-8	2019	On the other hand, montelukast suppressed the expression and production of matrix metalloproteinases (MMPs) and cytokines including MMP-2, MMP-9, interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6).	montelukast	19-30	interleukin 1 beta	Homo sapiens	146-163
31313075-8	2019	On the other hand, montelukast suppressed the expression and production of matrix metalloproteinases (MMPs) and cytokines including MMP-2, MMP-9, interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6).	montelukast	19-30	interleukin 1 beta	Homo sapiens	165-173
31001928-10	2019	This study suggests that PBM accelerates tooth movement during molar intrusion, due to modulation of IL-6, IL-8 and IL-1beta during bone remodeling.	pbm	25-28	interleukin 1 beta	Homo sapiens	116-124
31473434-7	2019	We found high glucose could increase Propidium Iodide (PI) positive cells and elevate release of lactate dehydrogenase (LDH), Interleukin 1 beta (IL-1beta) and Interleukin 18 (IL-18); protein levels of GSDMD, GSDMD N-terminal domain (GSDMD-N) and cleaved-caspase-1 were also elevated.	Glucose	14-21	interleukin 1 beta	Homo sapiens	126-144
31301116-6	2019	Blockage of P2Y11R by its antagonist suppresses IL-1beta-induced TNF-alpha and IL-6 induction and ameliorates oxidative stress as determined by levels of cellular ROS and the oxidative byproduct 4-HNE.	ros	163-166	interleukin 1 beta	Homo sapiens	48-56
31349378-0	2019	Melatonin reduces inflammatory response in human intestinal epithelial cells stimulated by interleukin-1beta.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	91-108
31328390-5	2019	Ligand (dexamethasone or triamcinolone acetonide)-activated GR induced dual specificity phosphatase (DUSP)1 expression via the glucocorticoid response element and attenuated IL-1beta-induced galectin-1/LGALS1 expression by reducing phosphorylation of these AP-1 subunits following AKT and extracellular signal-regulated kinase (ERK)1/2 deactivation.	Dexamethasone	8-21	interleukin 1 beta	Homo sapiens	174-182
31328390-5	2019	Ligand (dexamethasone or triamcinolone acetonide)-activated GR induced dual specificity phosphatase (DUSP)1 expression via the glucocorticoid response element and attenuated IL-1beta-induced galectin-1/LGALS1 expression by reducing phosphorylation of these AP-1 subunits following AKT and extracellular signal-regulated kinase (ERK)1/2 deactivation.	Triamcinolone Acetonide	25-48	interleukin 1 beta	Homo sapiens	174-182
31349378-9	2019	Our results showed that melatonin, at concentrations similar to those obtained in the lumen gut after ingestion of dietary supplements for the treatment of sleep disorders, was able to attenuate the inflammatory response induced by IL-1beta.	Melatonin	24-33	interleukin 1 beta	Homo sapiens	232-240
31383729-8	2019	THC treatment of the TLR7-stimulated coculture suppressed monocyte secretion of IL-1beta, resulting in decreased astrocyte production of MCP-1 and IL-6.	Dronabinol	0-3	interleukin 1 beta	Homo sapiens	80-88
31383729-9	2019	Furthermore, THC displayed direct inhibition of monocytes, as TLR7-stimulated monocyte monocultures treated with THC also showed suppressed IL-1beta production.	Dronabinol	13-16	interleukin 1 beta	Homo sapiens	140-148
31383729-9	2019	Furthermore, THC displayed direct inhibition of monocytes, as TLR7-stimulated monocyte monocultures treated with THC also showed suppressed IL-1beta production.	Dronabinol	113-116	interleukin 1 beta	Homo sapiens	140-148
31293088-0	2019	Preconditioning with interleukin-1 beta and interferon-gamma enhances the efficacy of human umbilical cord blood-derived mesenchymal stem cells-based therapy via enhancing prostaglandin E2 secretion and indoleamine 2,3-dioxygenase activity in dextran sulfate sodium-induced colitis.	Dinoprostone	172-188	interleukin 1 beta	Homo sapiens	21-39
31383729-10	2019	The cannabinoid receptor 2 (CB2) agonist, JWH-015, impaired monocyte IL-1beta production similar to that of THC, suggesting that THC acts, in part, through CB2.	JHW 015	42-49	interleukin 1 beta	Homo sapiens	69-77
31383729-11	2019	THC also suppressed key elements of the IL-1beta production pathway, including IL1B mRNA levels and caspase-1 activity.	Dronabinol	0-3	interleukin 1 beta	Homo sapiens	40-48
31383729-11	2019	THC also suppressed key elements of the IL-1beta production pathway, including IL1B mRNA levels and caspase-1 activity.	Dronabinol	0-3	interleukin 1 beta	Homo sapiens	79-83
31383729-12	2019	Collectively, this study demonstrates that the anti-inflammatory properties of THC suppress TLR7-induced monocyte secretion of IL-1beta through CB2, which results in decreased astrocyte secretion of MCP-1 and IL-6.	Dronabinol	79-82	interleukin 1 beta	Homo sapiens	127-135
31293088-0	2019	Preconditioning with interleukin-1 beta and interferon-gamma enhances the efficacy of human umbilical cord blood-derived mesenchymal stem cells-based therapy via enhancing prostaglandin E2 secretion and indoleamine 2,3-dioxygenase activity in dextran sulfate sodium-induced colitis.	Dextran Sulfate	243-265	interleukin 1 beta	Homo sapiens	21-39
31626100-6	2019	Besides analgesic, lidocaine has systemic anti-inflammatory and neuroprotective effect.Primary aim of this trial is to determine the influence of local anesthesia with lidocaine on the perioperative levels of pro-inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in plasma and CSF in cerebral aneurysm patients.	Lidocaine	19-28	interleukin 1 beta	Homo sapiens	236-253
31577702-0	2019	N-acetyl cysteine inhibits lipopolysaccharide-mediated synthesis of interleukin-1beta and tumor necrosis factor-alpha in human periodontal ligament fibroblast cells through nuclear factor-kappa B signaling.	Acetylcysteine	0-17	interleukin 1 beta	Homo sapiens	68-85
31626100-6	2019	Besides analgesic, lidocaine has systemic anti-inflammatory and neuroprotective effect.Primary aim of this trial is to determine the influence of local anesthesia with lidocaine on the perioperative levels of pro-inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in plasma and CSF in cerebral aneurysm patients.	Lidocaine	168-177	interleukin 1 beta	Homo sapiens	236-253
31577702-1	2019	BACKGROUND: The aim of this study was to investigate the role of n-acetyl cysteine (NAC) in the lipopolysaccharide (LPS)-mediated induction of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) synthesis by human periodontal ligament fibroblast cells (hPDLFs).	Acetylcysteine	65-82	interleukin 1 beta	Homo sapiens	187-204
31577702-1	2019	BACKGROUND: The aim of this study was to investigate the role of n-acetyl cysteine (NAC) in the lipopolysaccharide (LPS)-mediated induction of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) synthesis by human periodontal ligament fibroblast cells (hPDLFs).	Acetylcysteine	84-87	interleukin 1 beta	Homo sapiens	187-204
31238091-9	2019	IL-1beta induced mitochondrial activity within 30 min of treatment, altered mitochondrial related gene expression, altered mitochondrial morphology, enhanced adenoside triphosphate (ATP) utilization and increased the expression of inflammatory cytokines.	adenoside triphosphate	158-180	interleukin 1 beta	Homo sapiens	0-8
31362031-2	2019	We hypothesize that prolonged exposure of beta-cells to low concentrations of IL-1beta induce beta-cell dedifferentiation characterized by impaired glucose-stimulated insulin secretion, reduced expression of key beta-cell genes and changes in histone modifications at gene loci known to affect beta-cell function.	Glucose	148-155	interleukin 1 beta	Homo sapiens	78-86
31584250-0	2019	The Alternaria Mycotoxin Alternariol Triggers the Immune Response of IL-1beta-stimulated, Differentiated Caco-2 Cells.	alternariol	25-36	interleukin 1 beta	Homo sapiens	69-77
31584250-5	2019	METHODS AND RESULTS: The impact of AOH (0.02-40 microm) on inflammatory signaling in either IL-1beta-stimulated or non-stimulated differentiated Caco-2 cells is determined.	alternariol	35-38	interleukin 1 beta	Homo sapiens	92-100
31584250-6	2019	AOH significantly reduces IL-1beta transcription after 5 h but shows an increasing tendency on IL-8 transcript levels after long-term exposure (20 h).	alternariol	0-3	interleukin 1 beta	Homo sapiens	26-34
31584250-7	2019	In IL-1beta-stimulated cells, AOH (20-40 microm) augments TNF-alpha transcripts while repressing IL-8, IL-6, and IL-1beta transcription as well as IL-8 secretion.	alternariol	30-33	interleukin 1 beta	Homo sapiens	3-11
31584250-7	2019	In IL-1beta-stimulated cells, AOH (20-40 microm) augments TNF-alpha transcripts while repressing IL-8, IL-6, and IL-1beta transcription as well as IL-8 secretion.	alternariol	30-33	interleukin 1 beta	Homo sapiens	113-121
31524270-5	2019	The results revealed that emodin attenuated ATP-induced HPDE6-C7 cell injury by decreasing the levels of inflammatory factors, including interleukin (IL)-1beta and IL-18.	Adenosine Triphosphate	44-47	interleukin 1 beta	Homo sapiens	137-159
31396715-3	2019	TES products stimulated macrophages to produce the innate proinflammatory IL-1beta, IL-6, and TNF-alpha cytokines regardless of the presence of glycans.	TES	0-3	interleukin 1 beta	Homo sapiens	74-82
31162611-5	2019	Regardless of intestinal inflammation, supplementation with SB at 300 mg/kg significantly decreased the levels of D (-)-lactate (P &lt; 0.05), interleukin-6, and interleukin-1beta (P &lt; 0.05) but increased the level of interleukin-10 (P &lt; 0.05).	Butyric Acid	60-62	interleukin 1 beta	Homo sapiens	162-179
31348843-10	2019	Prostate cancer cells increased the expression of interleukin1beta (IL1beta), IL10, and IL6 in monocytes which was inhibited by galiellalactone.	galiellalactone	128-143	interleukin 1 beta	Homo sapiens	50-66
31416745-7	2019	The amelioration of cognitive deficits with minocycline correlated not only with the remission of negative symptoms, but also with the reduction in serum levels of IL-1beta and IL-6.	Minocycline	44-55	interleukin 1 beta	Homo sapiens	164-172
31238091-9	2019	IL-1beta induced mitochondrial activity within 30 min of treatment, altered mitochondrial related gene expression, altered mitochondrial morphology, enhanced adenoside triphosphate (ATP) utilization and increased the expression of inflammatory cytokines.	Adenosine Triphosphate	182-185	interleukin 1 beta	Homo sapiens	0-8
31872639-11	2019	Compared with IR model group,wogonoside not only inhibited the protein expression of inflammatory nuclear transcriptional factors NLRP3,SOCS3,TLR4,NF-kappaB,but also decreased the expression of downstream inflammatory effect factors IL-1beta,IL-6 and TNF-alpha.	wogonoside	29-39	interleukin 1 beta	Homo sapiens	233-241
31571967-8	2019	In vitro, the expression of NLRP3 inflammasome components and the secretion of IL-1beta were augmented by high glucose in HUVECs.	Glucose	111-118	interleukin 1 beta	Homo sapiens	79-87
31558729-5	2019	Anti-inflammatory agents, such corticosteroids, NSAIDs and colchicine, are widely used for the treatment of gout flare; recognition of the importance of NLRP3 inflammasome activation and bioactive IL-1beta release in initiation of the gout flare has led to the development of anti-IL-1beta biological therapy for gout flares.	Colchicine	59-69	interleukin 1 beta	Homo sapiens	281-289
31571967-9	2019	Moreover, either high glucose or IL-1beta promoted the expression of adhesion molecules, which were suppressed by NLRP3 knockdown or IL-1beta receptor antagonist.	Glucose	22-29	interleukin 1 beta	Homo sapiens	133-141
31536594-5	2019	Our results showed that in cells transfected with ATF-2 siRNA or treated with the ATF-2 inhibitor SBI-0087702, IL-1beta-induced MMP-3 mRNA expression was reduced.	SBI-0087702	98-109	interleukin 1 beta	Homo sapiens	111-119
31536594-13	2019	While the ERK inhibitor FR180204 inhibited IL-1beta-induced ATF-2 phosphorylation, only in cells transfected with ERK1 siRNA, but not ERK2 siRNA, IL-1beta-induced ATF-2 phosphorylation was reduced.	FR 180204	24-32	interleukin 1 beta	Homo sapiens	43-51
31536594-13	2019	While the ERK inhibitor FR180204 inhibited IL-1beta-induced ATF-2 phosphorylation, only in cells transfected with ERK1 siRNA, but not ERK2 siRNA, IL-1beta-induced ATF-2 phosphorylation was reduced.	FR 180204	24-32	interleukin 1 beta	Homo sapiens	146-154
31533789-8	2019	However, the patient frequently needed an increase in the dose of colchicine, suggesting the possible usefulness of anti-interleukin-1 beta treatment.	Colchicine	66-76	interleukin 1 beta	Homo sapiens	121-139
31358323-9	2019	Enhanced expression of NLRP3, caspase-1, and IL-1beta was noted in macrophages treated with LPS (10 ng/ml) and MSU crystals (0.1 mg/ml), which was markedly suppressed by treatment with artemisinin (1, 10, and 100 muM).	Uric Acid	111-114	interleukin 1 beta	Homo sapiens	45-53
31860633-9	2019	AMD3465 significantly reduced the protein expression levels of TNF-alpha, IL-1beta, NF-kappaB, and p-p65.	N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylenebis(methylene))-2-(aminomethyl)- pyridine	0-7	interleukin 1 beta	Homo sapiens	74-82
31358323-9	2019	Enhanced expression of NLRP3, caspase-1, and IL-1beta was noted in macrophages treated with LPS (10 ng/ml) and MSU crystals (0.1 mg/ml), which was markedly suppressed by treatment with artemisinin (1, 10, and 100 muM).	artemisinin	185-196	interleukin 1 beta	Homo sapiens	45-53
31551929-9	2019	Exposure to BPA significantly increased CD4+ T cells, IFNgamma, IL-17A, TLR4, caspase-1, and IL-1beta in the heart.	bisphenol A	12-15	interleukin 1 beta	Homo sapiens	93-101
31270213-8	2019	These markers were inhibited in OA-associated chondrocytes and in chondrocytes activated by interleukin-1beta (IL1beta), but also chondrocytes activated by lipopolysaccharide (LPS), tumor necrosis factor alpha (TNFalpha), or HA oligosaccharides.	Oligosaccharides	228-244	interleukin 1 beta	Homo sapiens	111-118
31513661-6	2019	Refractory DME patients showed significantly higher number of hyperreflective foci (HF) in the OCT and higher average level of aqueous IL-1beta at baseline (p&lt;0.001 and p = 0.042, respectively).	dme	11-14	interleukin 1 beta	Homo sapiens	135-143
31551774-5	2019	Animal research further indicated, at the 3rd and 7th days after infection, LEP and DPEP significantly attenuated lung injury, decreased lung index, virus load in the lung and the level of IL-1beta in serum, inhibited the mRNA expression levels of TNF-alpha, TLR3, TLR4, TLR7, MyD88, NF-kappaB p65 and RIG-1 as well as the protein expression levels of TLR4, TLR7, MyD88 and NF-kappaB p65 and markedly increased thymus index, the level of IL-10 in serum and the mRNA expression level of IFN-gamma.	Ephedrine	76-79	interleukin 1 beta	Homo sapiens	189-197
31646085-10	2019	Treatment of TAM with ibrutinib significantly impaired the ability of these cells to produce IL-1beta.	ibrutinib	22-31	interleukin 1 beta	Homo sapiens	93-101
31646085-11	2019	The present study provides evidence that BTK physically associates with the NLRP3 inflammasome and that inhibition of BTK with ibrutinib can impair the production of IL-1beta by in vitro generated TAM.	ibrutinib	127-136	interleukin 1 beta	Homo sapiens	166-174
31420217-2	2019	Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine synthesis pathway, and one-carbon metabolism, the synergism of which drives epigenetic reprogramming for interleukin-1beta (IL-1beta) expression.	Pentosephosphates	58-75	interleukin 1 beta	Homo sapiens	201-218
31420217-2	2019	Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine synthesis pathway, and one-carbon metabolism, the synergism of which drives epigenetic reprogramming for interleukin-1beta (IL-1beta) expression.	Serine	89-95	interleukin 1 beta	Homo sapiens	201-218
31420217-2	2019	Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine synthesis pathway, and one-carbon metabolism, the synergism of which drives epigenetic reprogramming for interleukin-1beta (IL-1beta) expression.	Carbon	123-129	interleukin 1 beta	Homo sapiens	201-218
31237033-3	2019	Moreover, saponin induced IL1beta and MCP1 release and did not affect the complement system.	Saponins	10-17	interleukin 1 beta	Homo sapiens	26-33
31264347-8	2019	Dietary berberine significantly mitigated the LPS-induced decreases in the mRNA expression of nuclear factor-kappa B (NF-kappaB), TNF-alpha, IL-1beta, inducible nitrite synthase and cyclooxygenase-2 (p &lt; 0.05) in the liver.	Berberine	8-17	interleukin 1 beta	Homo sapiens	141-149
31237033-6	2019	Inulin, agarose and cellulose induced IL1beta and MCP1 release, while dextran had no effect on cytokine secretion.	Sepharose	8-15	interleukin 1 beta	Homo sapiens	38-45
31237033-6	2019	Inulin, agarose and cellulose induced IL1beta and MCP1 release, while dextran had no effect on cytokine secretion.	Cellulose	20-29	interleukin 1 beta	Homo sapiens	38-45
31237033-7	2019	Zymosan mainly induced IL1beta release.	Zymosan	0-7	interleukin 1 beta	Homo sapiens	23-30
31033140-14	2019	When studying the relationship between digestive compounds and amniotic fluid inflammatory markers, a clear correlation was found between bile acid and both ferritin and interleukin 1beta (IL1beta).	Bile Acids and Salts	138-147	interleukin 1 beta	Homo sapiens	170-187
31700876-9	2019	PQQ can significantly reverse this phenomenon, as evidenced by the decreased levels of proinflammatory cytokines IL-6, IL-1beta and TNF-alpha.	PQQ Cofactor	0-3	interleukin 1 beta	Homo sapiens	119-127
31033140-14	2019	When studying the relationship between digestive compounds and amniotic fluid inflammatory markers, a clear correlation was found between bile acid and both ferritin and interleukin 1beta (IL1beta).	Bile Acids and Salts	138-147	interleukin 1 beta	Homo sapiens	189-196
31260663-0	2019	Effects of simvastatin on matrix metalloproteinase regulation in IL-1beta-induced SW1353 cells.	Simvastatin	11-22	interleukin 1 beta	Homo sapiens	65-73
31176166-9	2019	Furthermore, melatonin reversed changes in the expression of EMT markers induced by IL-1beta by increasing mRNA levels of beta-catenin and E-cadherin and decreasing those of fibronectin, vimentin, and Snail compared to IL-1beta.	Melatonin	13-22	interleukin 1 beta	Homo sapiens	84-92
31176166-9	2019	Furthermore, melatonin reversed changes in the expression of EMT markers induced by IL-1beta by increasing mRNA levels of beta-catenin and E-cadherin and decreasing those of fibronectin, vimentin, and Snail compared to IL-1beta.	Melatonin	13-22	interleukin 1 beta	Homo sapiens	219-227
31176166-10	2019	Treatment with IL-1beta upregulated the expression and activities of MMP-2 and MMP-9 and expression of NF-kappaB p65 and phospho-p65 (p-p65), but melatonin alleviated these effects.	Melatonin	146-155	interleukin 1 beta	Homo sapiens	15-23
31176166-11	2019	SIGNIFICANCE: Melatonin inhibited IL-1beta-induced lung metastasis of gastric cancer through downregulation of MMP-2, MMP-9, and NF-kappaB p65 expression and activities.	Melatonin	14-23	interleukin 1 beta	Homo sapiens	34-42
31497826-5	2019	In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes.	Dinoprostone	121-125	interleukin 1 beta	Homo sapiens	27-45
31497826-0	2019	Urolithin A targets the PI3K/Akt/NF-kappaB pathways and prevents IL-1beta-induced inflammatory response in human osteoarthritis: in vitro and in vivo studies.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	0-11	interleukin 1 beta	Homo sapiens	65-73
31497826-5	2019	In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	10-12	interleukin 1 beta	Homo sapiens	27-45
31497826-5	2019	In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	10-12	interleukin 1 beta	Homo sapiens	47-55
31497826-5	2019	In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes.	Nitric Oxide	84-96	interleukin 1 beta	Homo sapiens	27-45
31497826-5	2019	In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes.	Nitric Oxide	84-96	interleukin 1 beta	Homo sapiens	47-55
31474553-3	2019	METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1beta) were up-regulated and represented dose-dependent differential expression in controls, low-dose benzene-exposed and chronic benzene-poisoned workers, and the expression of Casp1 and IL1beta were confirmed in low-dose benzene-exposed workers and was accompanied with elevated potent proinflammatory IL1beta.	Benzene	201-208	interleukin 1 beta	Homo sapiens	97-104
31474553-3	2019	METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1beta) were up-regulated and represented dose-dependent differential expression in controls, low-dose benzene-exposed and chronic benzene-poisoned workers, and the expression of Casp1 and IL1beta were confirmed in low-dose benzene-exposed workers and was accompanied with elevated potent proinflammatory IL1beta.	Benzene	201-208	interleukin 1 beta	Homo sapiens	287-294
31474553-3	2019	METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1beta) were up-regulated and represented dose-dependent differential expression in controls, low-dose benzene-exposed and chronic benzene-poisoned workers, and the expression of Casp1 and IL1beta were confirmed in low-dose benzene-exposed workers and was accompanied with elevated potent proinflammatory IL1beta.	Benzene	201-208	interleukin 1 beta	Homo sapiens	287-294
31474553-3	2019	METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1beta) were up-regulated and represented dose-dependent differential expression in controls, low-dose benzene-exposed and chronic benzene-poisoned workers, and the expression of Casp1 and IL1beta were confirmed in low-dose benzene-exposed workers and was accompanied with elevated potent proinflammatory IL1beta.	Benzene	229-236	interleukin 1 beta	Homo sapiens	97-104
31474553-3	2019	METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1beta) were up-regulated and represented dose-dependent differential expression in controls, low-dose benzene-exposed and chronic benzene-poisoned workers, and the expression of Casp1 and IL1beta were confirmed in low-dose benzene-exposed workers and was accompanied with elevated potent proinflammatory IL1beta.	Benzene	229-236	interleukin 1 beta	Homo sapiens	287-294
31474553-3	2019	METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1beta) were up-regulated and represented dose-dependent differential expression in controls, low-dose benzene-exposed and chronic benzene-poisoned workers, and the expression of Casp1 and IL1beta were confirmed in low-dose benzene-exposed workers and was accompanied with elevated potent proinflammatory IL1beta.	Benzene	229-236	interleukin 1 beta	Homo sapiens	287-294
31474553-3	2019	METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1beta) were up-regulated and represented dose-dependent differential expression in controls, low-dose benzene-exposed and chronic benzene-poisoned workers, and the expression of Casp1 and IL1beta were confirmed in low-dose benzene-exposed workers and was accompanied with elevated potent proinflammatory IL1beta.	Benzene	229-236	interleukin 1 beta	Homo sapiens	97-104
31474553-3	2019	METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1beta) were up-regulated and represented dose-dependent differential expression in controls, low-dose benzene-exposed and chronic benzene-poisoned workers, and the expression of Casp1 and IL1beta were confirmed in low-dose benzene-exposed workers and was accompanied with elevated potent proinflammatory IL1beta.	Benzene	229-236	interleukin 1 beta	Homo sapiens	287-294
31474553-3	2019	METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1beta) were up-regulated and represented dose-dependent differential expression in controls, low-dose benzene-exposed and chronic benzene-poisoned workers, and the expression of Casp1 and IL1beta were confirmed in low-dose benzene-exposed workers and was accompanied with elevated potent proinflammatory IL1beta.	Benzene	229-236	interleukin 1 beta	Homo sapiens	287-294
31464310-4	2019	In the present study, we identified that cyanidin treatment could strongly suppress the expression of NO, PGE2, TNF-alpha, IL-6, iNOs, COX-2, ADAMTS5 and MMP13, and reduce the degradation of aggrecan and collagen II in IL-1beta-induced human OA chondrocytes, indicating the anti-inflammatory effect of cyanidin.	cyanidin	41-49	interleukin 1 beta	Homo sapiens	219-227
31464310-5	2019	Further investigation of the mechanism involved revealed that cyanidin could upregulate the Sirt6 level in a dose-dependent manner and Sirt6 silencing abolished the effect of cyanidin in IL-1beta-stimulated human OA chondrocytes, indicating a stimulatory effect of cyanidin on Sirt6 activation.	cyanidin	175-183	interleukin 1 beta	Homo sapiens	187-195
31464310-5	2019	Further investigation of the mechanism involved revealed that cyanidin could upregulate the Sirt6 level in a dose-dependent manner and Sirt6 silencing abolished the effect of cyanidin in IL-1beta-stimulated human OA chondrocytes, indicating a stimulatory effect of cyanidin on Sirt6 activation.	cyanidin	175-183	interleukin 1 beta	Homo sapiens	187-195
31464310-6	2019	Meanwhile, we found that cyanidin could inhibit the NF-kappaB pathway in IL-1beta-stimulated human OA chondrocytes and its effect may to some extent depend on Sirt6 activation, suggesting that cyanidin may exert a protective effect through regulating the Sirt6/NF-kappaB signaling axis.	cyanidin	25-33	interleukin 1 beta	Homo sapiens	73-81
31464310-6	2019	Meanwhile, we found that cyanidin could inhibit the NF-kappaB pathway in IL-1beta-stimulated human OA chondrocytes and its effect may to some extent depend on Sirt6 activation, suggesting that cyanidin may exert a protective effect through regulating the Sirt6/NF-kappaB signaling axis.	cyanidin	193-201	interleukin 1 beta	Homo sapiens	73-81
31497826-5	2019	In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes.	Dinoprostone	103-119	interleukin 1 beta	Homo sapiens	27-45
31497826-5	2019	In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes.	Dinoprostone	103-119	interleukin 1 beta	Homo sapiens	47-55
31497826-5	2019	In vitro, UA inhibited the interleukin-1 beta (IL-1beta) induced over-production of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a concentration-dependent manner in human OA chondrocytes.	Dinoprostone	121-125	interleukin 1 beta	Homo sapiens	47-55
31257463-7	2019	TxT + H/R-induced increases in the gene expression of interleukin (IL)-6 and intercellular adhesion molecule-1 and the protein expression of tumor necrosis factor (TNF)-alpha and IL-1beta were significantly reduced in both EtOH groups compared with those in the corresponding TxT + H/R ctrl groups.	r	8-9	interleukin 1 beta	Homo sapiens	179-187
31111539-6	2019	Poly (I:C) significantly upregulated proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and type I interferon (IFN-alpha/beta), and the innate immune responses were significantly reduced by blocking TLR3 signaling.	Poly I-C	0-9	interleukin 1 beta	Homo sapiens	135-143
31358383-0	2019	Erratum to "Methylsulfonylmethane and mobilee prevent negative effect of IL-1beta in human chondrocyte cultures via NF-kappaB signaling pathway" [Int.	dimethyl sulfone	12-33	interleukin 1 beta	Homo sapiens	73-81
31257463-7	2019	TxT + H/R-induced increases in the gene expression of interleukin (IL)-6 and intercellular adhesion molecule-1 and the protein expression of tumor necrosis factor (TNF)-alpha and IL-1beta were significantly reduced in both EtOH groups compared with those in the corresponding TxT + H/R ctrl groups.	Ethanol	223-227	interleukin 1 beta	Homo sapiens	179-187
30824640-2	2019	METHODS: Primary human monocytes and the THP-1 human monocyte cell line were used to determine the effects of short- and longterm exposure to UA on activation of the NLRP3 inflammasome and subsequent interleukin 1beta (IL-1beta) secretion by ELISA and cell-based assays.	Uric Acid	142-144	interleukin 1 beta	Homo sapiens	200-217
31009103-5	2019	Eriodictyol significantly reduced RA-FLS secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), IL-8, and IL-1beta.	eriodictyol	0-11	interleukin 1 beta	Homo sapiens	115-123
30824640-4	2019	RESULTS: Precipitation of UA was required for activation of the NLRP3 inflammasome and subsequent release of IL-1beta in human monocytes.	Uric Acid	26-28	interleukin 1 beta	Homo sapiens	109-117
31480578-5	2019	The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1beta, IL-6, VEGF, MIP-2, and TNF-alpha) compared to the raw Curcumin.	Curcumin	4-12	interleukin 1 beta	Homo sapiens	155-163
30712124-9	2019	The interaction between H2O2 at 50 muM and LLLT at 4 J showed partially reversion of the higher levels of DNA oxidation, CASP 3, CASP 8, IL-1B, IL-6, and INFy induced by H2O2 exposure.	Hydrogen Peroxide	24-28	interleukin 1 beta	Homo sapiens	137-142
30712124-9	2019	The interaction between H2O2 at 50 muM and LLLT at 4 J showed partially reversion of the higher levels of DNA oxidation, CASP 3, CASP 8, IL-1B, IL-6, and INFy induced by H2O2 exposure.	Hydrogen Peroxide	170-174	interleukin 1 beta	Homo sapiens	137-142
31211952-3	2019	Consistent with these results, CDMP also down-regulated inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 6 (IL-6) at the protein and mRNA levels in LPS-treated RAW 264.7 macrophages.	cdmp	31-35	interleukin 1 beta	Homo sapiens	163-180
30606080-14	2019	Mitogen-activated protein kinase kinase 1 and 2, JNK, and NFkappaB signaling mediate IL-1beta-, TNF-alpha-, and IFN-gamma-induced CX3CL1 production by FTDCs.	ftdcs	151-156	interleukin 1 beta	Homo sapiens	85-93
31695408-10	2019	Estrogen enhanced NLPR3, ERbeta, pro-IL-1beta, IL-1beta expression, and endometrial cancer cell proliferation, which were mitigated by treatment with ERbeta inhibitor but not ERalpha inhibitor.	Estrogens	0-8	interleukin 1 beta	Homo sapiens	33-45
31695408-10	2019	Estrogen enhanced NLPR3, ERbeta, pro-IL-1beta, IL-1beta expression, and endometrial cancer cell proliferation, which were mitigated by treatment with ERbeta inhibitor but not ERalpha inhibitor.	Estrogens	0-8	interleukin 1 beta	Homo sapiens	37-45
31211952-7	2019	Taken together, our data suggest that CDMP down-regulates genes encoding pro-inflammatory mediators and cytokines, such as iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 via NF-kappaB and JNK/AP-1 inactivation in LPS-induced RAW 264.7 macrophages.	cdmp	38-42	interleukin 1 beta	Homo sapiens	147-155
30863869-12	2019	Treatment with a demethylation agent, 5-Aza-2"-deoxycytidine resulted in an increase of FKBP5 mRNA expression and a stimulated IL-1beta production.	Decitabine	38-60	interleukin 1 beta	Homo sapiens	127-135
31211952-3	2019	Consistent with these results, CDMP also down-regulated inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 6 (IL-6) at the protein and mRNA levels in LPS-treated RAW 264.7 macrophages.	cdmp	31-35	interleukin 1 beta	Homo sapiens	182-190
31462987-10	2019	Besides, high-glucose (25 mM) inhibited HRECs viability and induced oxidative stress, inflammation associated cytokines (TNF-alpha, IL-6 and IL-1beta) secretion and cell apoptosis, which were all reversed by synergistically overexpressing CKIP-1 and aggravated by knocking down CKIP-1.	Glucose	14-21	interleukin 1 beta	Homo sapiens	141-149
31300552-7	2019	Cardiac glycoside-induced cellular cytotoxicity and IL-1beta signaling are likewise antagonized by inhibitors of the NLRP3 inflammasome or the IL-1 receptor-targeting biological agent anakinra.	Glycosides	8-17	interleukin 1 beta	Homo sapiens	52-60
31534438-6	2019	We found that poly I:C induced increased expression of the proinflammatory cytokines IL1beta, IL6, CXCL8, and TNF and IFN-beta1 in AECs from both control subjects and COPD patients.	Poly I-C	14-22	interleukin 1 beta	Homo sapiens	85-92
31474993-6	2019	IL-1beta inhibited aquaporins expression and led to water re-absorption disorder.	Water	52-57	interleukin 1 beta	Homo sapiens	0-8
31497226-9	2019	IL-1beta promoted the progress of IDD, and the stimulation of GL could reverse the effects of IL-1beta.	Glycyrrhizic Acid	62-64	interleukin 1 beta	Homo sapiens	94-102
31226416-8	2019	GOS pre-treatment significantly attenuated LPS-induced cell injury, as evidenced by the increase of cell viability, the decrease of apoptosis, as well as the suppressed release of TNF-alpha, IFN-gamma and IL-1beta.	D-Glucitol-1,6-bisphosphate	0-3	interleukin 1 beta	Homo sapiens	205-213
31409424-11	2019	In the presence of extracellular ATP, cocultures of MSCs reduced cytotoxicity and allows for proliferation of lymphocytes while limiting IL-1beta secretion from monocytes.	Adenosine Triphosphate	33-36	interleukin 1 beta	Homo sapiens	137-145
31412063-7	2019	Treatment of HSVEC with exogenous ATP led to interleukin 1beta (IL-1beta) release and increased vascular cell adhesion molecule (VCAM) expression.	Adenosine Triphosphate	34-37	interleukin 1 beta	Homo sapiens	45-62
30657173-7	2019	The protein production of the proinflammatory cytokines TNF-alpha, interferon gamma, IL-1beta, IL-6 and IL-17A was significantly inhibited by adalimumab, infliximab, ustekinumab, prednisolone (all P &lt; 0 001) and rituximab (P = 0 0071), but not by secukinumab (P = 0 0663).	Prednisolone	179-191	interleukin 1 beta	Homo sapiens	85-93
31381554-0	2019	Salidroside Suppresses IL-1beta-Induced Apoptosis in Chondrocytes via Phosphatidylinositol 3-Kinases (PI3K)/Akt Signaling Inhibition.	rhodioloside	0-11	interleukin 1 beta	Homo sapiens	23-31
31005727-8	2019	In presence of OSCC an increased concentration of IL-8(p = 0.004), IL-6(p = 0.005), VEGF(p = 0.014), MIP-1ss(p = 0.033), IP-10(p = 0.047), IL-1beta(p = 0.049) was observed; conversely the concentration of IFN-gamma(p = 0.036) and IL-5(P = 0.048) decreased.	oscc	15-19	interleukin 1 beta	Homo sapiens	139-147
31350748-7	2019	As neutrophils, monocytes and macrophages are the key cells and Interleukin 1beta is one of the dominant cytokines the way of blocking inflammation by colchicine and override IL-1beta are specific options in treating inflammation due to the crystals.	Colchicine	151-161	interleukin 1 beta	Homo sapiens	64-81
31265218-7	2019	XO-produced ROS also increase the synthesis of pro-IL-1beta, while the parasite activates caspase-1, providing the two necessary signals for the activation of the NLRP3 inflammasome.	Reactive Oxygen Species	12-15	interleukin 1 beta	Homo sapiens	51-59
30679324-0	2019	All-trans retinoic acid protects mesenchymal stem cells from immune thrombocytopenia by regulating the complement-interleukin-1beta loop.	2-octenal	4-9	interleukin 1 beta	Homo sapiens	114-131
31039328-4	2019	TNF-alpha or IL-1beta stimulation reduced the expression of RNase1 relative to the acetylation state of histone 3 at lysine 27 and histone 4 of the RNASE1 promoter.	Lysine	117-123	interleukin 1 beta	Homo sapiens	13-21
31039328-5	2019	Inhibition of histone deacetylase (HDAC) 1, 2, and 3 by the specific class I HDAC inhibitor MS275 abolished the TNF-alpha- or IL-1beta-mediated effect on the mRNA and chromatin levels of RNase1.	entinostat	92-97	interleukin 1 beta	Homo sapiens	126-134
30679324-0	2019	All-trans retinoic acid protects mesenchymal stem cells from immune thrombocytopenia by regulating the complement-interleukin-1beta loop.	Tretinoin	10-23	interleukin 1 beta	Homo sapiens	114-131
30679324-6	2019	In vitro treatment with all-trans retinoic acid increased the number and improved the function of the complement-positive bone marrow mesenchymal stem cells by upregulating DNA hypermethylation of the interleukin-1beta promoter.	Tretinoin	34-47	interleukin 1 beta	Homo sapiens	201-218
31078926-5	2019	The Teneligliptin recovered LPS-induced a reduction of cellular glutathione and produced cytokine including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6).	3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine	4-17	interleukin 1 beta	Homo sapiens	149-166
31069604-6	2019	DEX (1.000 nM) treatment in PBMC of SSc patients stimulated with anti-CD3 and anti-CD28 promoted a significant reduction in IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-gamma, TNF, IL-1beta (p &lt; 0.001 for all), and IL-17F (p = 0.023) cytokines levels.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	173-181
30848409-0	2019	Heteroleptic Ruthenium Polypyridyl Complex Had Differential Effects on the Production of Pro-inflammatory Cytokines TNFalpha, IL1beta, and IL6 by the Mammalian Macrophages In Vitro.	ruthenium polypyridyl complex	13-42	interleukin 1 beta	Homo sapiens	126-133
31293216-0	2019	Astragaloside inhibits IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.	astragaloside	0-13	interleukin 1 beta	Homo sapiens	23-31
31293216-5	2019	Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling.	astragaloside	19-32	interleukin 1 beta	Homo sapiens	72-80
31293216-5	2019	Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling.	Nitric Oxide	202-214	interleukin 1 beta	Homo sapiens	72-80
31293216-5	2019	Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling.	Dinoprostone	221-237	interleukin 1 beta	Homo sapiens	72-80
31293216-5	2019	Results: In vitro, astragaloside induced a dose-dependent inhibition of IL-1beta-induced the production of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), prostaglandin E2 (PGE2), expression of MMP 13 and ADAMTS-5, and the activation of NF-kappaB signaling.	Dinoprostone	239-243	interleukin 1 beta	Homo sapiens	72-80
31078926-5	2019	The Teneligliptin recovered LPS-induced a reduction of cellular glutathione and produced cytokine including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6).	3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine	4-17	interleukin 1 beta	Homo sapiens	168-176
30912175-0	2019	Exposures to the environmental contaminants pentachlorophenol and dichlorodiphenyltrichloroethane increase production of the proinflammatory cytokine, interleukin-1beta, in human immune cells.	Pentachlorophenol	44-61	interleukin 1 beta	Homo sapiens	151-168
30912175-0	2019	Exposures to the environmental contaminants pentachlorophenol and dichlorodiphenyltrichloroethane increase production of the proinflammatory cytokine, interleukin-1beta, in human immune cells.	DDT	66-97	interleukin 1 beta	Homo sapiens	151-168
30912175-5	2019	Previous studies showed that PCP and DDT at certain concentrations were able to stimulate secretion of IL-1beta.	Pentachlorophenol	29-32	interleukin 1 beta	Homo sapiens	103-111
30912175-5	2019	Previous studies showed that PCP and DDT at certain concentrations were able to stimulate secretion of IL-1beta.	DDT	37-40	interleukin 1 beta	Homo sapiens	103-111
30912175-8	2019	DDT-induced stimulation of IL-1beta appeared to be maximal after 6 hours of exposure and then diminished by 24 hours.	DDT	0-3	interleukin 1 beta	Homo sapiens	27-35
30912175-9	2019	The increases seen in IL-1beta production stimulated by PCP appear to be at least partially due to compound-induced increases in IL-1beta mRNA.	Pentachlorophenol	56-59	interleukin 1 beta	Homo sapiens	22-30
30912175-9	2019	The increases seen in IL-1beta production stimulated by PCP appear to be at least partially due to compound-induced increases in IL-1beta mRNA.	Pentachlorophenol	56-59	interleukin 1 beta	Homo sapiens	129-137
30912175-10	2019	Although DDT caused increased production of IL-1beta, it did not appear to cause consistent increases in its mRNA.	DDT	9-12	interleukin 1 beta	Homo sapiens	44-52
30912175-11	2019	PCP- and DDT-induced increases in IL-1beta production were dependent primarily on the p38 mitogen-activated protein kinase pathway.	Pentachlorophenol	0-3	interleukin 1 beta	Homo sapiens	34-42
30912175-11	2019	PCP- and DDT-induced increases in IL-1beta production were dependent primarily on the p38 mitogen-activated protein kinase pathway.	DDT	9-12	interleukin 1 beta	Homo sapiens	34-42
30912175-12	2019	These results indicate that both PCP and DDT are able to increase IL-1beta production in a p38 mitogen-activated protein kinase-dependent manner, which may have the potential to influence chronic inflammation.	Pentachlorophenol	33-36	interleukin 1 beta	Homo sapiens	66-74
30912175-12	2019	These results indicate that both PCP and DDT are able to increase IL-1beta production in a p38 mitogen-activated protein kinase-dependent manner, which may have the potential to influence chronic inflammation.	DDT	41-44	interleukin 1 beta	Homo sapiens	66-74
31256283-6	2019	These analogs compounds showed effect better than compound BBG and similar to inhibitor A740003 for inhibiting dye uptake, in vitro IL-1beta release and ATP-induced paw edema in vivo.	(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)	88-95	interleukin 1 beta	Homo sapiens	132-140
30843219-7	2019	HQ prevented the interleukin (IL)-1beta-induced 8-isoprostane, and PGE2 production, but not IL-8 production of pulp cells.	8-epi-prostaglandin F2alpha	48-61	interleukin 1 beta	Homo sapiens	17-39
30843219-7	2019	HQ prevented the interleukin (IL)-1beta-induced 8-isoprostane, and PGE2 production, but not IL-8 production of pulp cells.	Dinoprostone	67-71	interleukin 1 beta	Homo sapiens	17-39
30891836-0	2019	Isofraxidin attenuates IL-1beta-induced inflammatory response in human nucleus pulposus cells.	isofraxidin	0-11	interleukin 1 beta	Homo sapiens	23-31
30891836-4	2019	The aim of this study was to evaluate the effects of isofraxidin on inflammatory response in human nucleus pulposus cells (NPCs) exposed to interleukin-1beta (IL-1beta).	isofraxidin	53-64	interleukin 1 beta	Homo sapiens	140-157
30891836-4	2019	The aim of this study was to evaluate the effects of isofraxidin on inflammatory response in human nucleus pulposus cells (NPCs) exposed to interleukin-1beta (IL-1beta).	isofraxidin	53-64	interleukin 1 beta	Homo sapiens	159-167
30891836-5	2019	The results proved that isofraxidin attenuated the IL-1beta-induced significant increases in inflammatory mediators and cytokines including nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and IL-6.	isofraxidin	24-35	interleukin 1 beta	Homo sapiens	51-59
30891836-5	2019	The results proved that isofraxidin attenuated the IL-1beta-induced significant increases in inflammatory mediators and cytokines including nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and IL-6.	Nitric Oxide	140-152	interleukin 1 beta	Homo sapiens	51-59
30891836-5	2019	The results proved that isofraxidin attenuated the IL-1beta-induced significant increases in inflammatory mediators and cytokines including nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and IL-6.	Dinoprostone	215-231	interleukin 1 beta	Homo sapiens	51-59
30891836-5	2019	The results proved that isofraxidin attenuated the IL-1beta-induced significant increases in inflammatory mediators and cytokines including nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and IL-6.	Dinoprostone	233-237	interleukin 1 beta	Homo sapiens	51-59
30891836-6	2019	Besides, isofraxidin also inhibited the induction effect of IL-1beta on matrix metalloproteinases (MMP)-3 and MMP-13.	isofraxidin	9-20	interleukin 1 beta	Homo sapiens	60-68
30891836-7	2019	Moreover, the NF-kappaB activation caused by IL-1beta was significantly inhibited by isofraxidin treatment.	isofraxidin	85-96	interleukin 1 beta	Homo sapiens	45-53
31132733-5	2019	In addition, L-fucose can inhibit macrophage M1 polarization, inactivate the NLRP3 inflammasome and reduce the release of TNFalpha, IL1beta, IL6 pro-inflammatory cytokines.	Fucose	13-21	interleukin 1 beta	Homo sapiens	132-139
31129418-5	2019	Herein, we demonstrate that Rev-erbalpha reduces IL-1beta production and lung injury following an intraperitoneal injection of LPS, which is dependent on the NF-kappaB/NALP3 pathway.	rev-erbalpha	28-40	interleukin 1 beta	Homo sapiens	49-57
30891836-8	2019	These findings suggested that isofraxidin alleviates IL-1beta-induced inflammation in NPCs.	isofraxidin	30-41	interleukin 1 beta	Homo sapiens	53-61
31129418-6	2019	Thus, Rev-erbalpha is able to decrease the extent of acute lung injury by regulating IL-1beta production.	rev-erbalpha	6-18	interleukin 1 beta	Homo sapiens	85-93
30919009-11	2019	alpha-ZOL + beta-ZOL showed antagonistic effects on inflammation for IL-1beta and TNF-alpha, but act synergic for IL-8 at high toxin concentrations.	zearalenol	0-9	interleukin 1 beta	Homo sapiens	69-77
30919009-11	2019	alpha-ZOL + beta-ZOL showed antagonistic effects on inflammation for IL-1beta and TNF-alpha, but act synergic for IL-8 at high toxin concentrations.	zearalenol	12-20	interleukin 1 beta	Homo sapiens	69-77
31055848-9	2019	Vitexin suppressed IL-1beta-induced production of NO and prostaglandin E2 (PGE2 ) in chondrocytes culture.	Dinoprostone	57-73	interleukin 1 beta	Homo sapiens	19-27
31055848-9	2019	Vitexin suppressed IL-1beta-induced production of NO and prostaglandin E2 (PGE2 ) in chondrocytes culture.	Dinoprostone	75-79	interleukin 1 beta	Homo sapiens	19-27
31453296-6	2019	In T1D patients, we show that secretion of cytokines IL-1beta, TNFalpha, IL-6 and IFNalpha after microbial DNA stimulation is promoted by potassium efflux and is not dependent on P2X7 receptor signaling.	Potassium	138-147	interleukin 1 beta	Homo sapiens	53-61
31270294-9	2019	The heterozygous TC genotype of IL1B rs16944 had an adjusted odds ratio (aOR) of 1.4209 (1.1302-1.8929) (P = 0.0019), while the homozygous CC genotype had an aOR of 1.7398 (1.2133-2.3203) (P = 0.0008).	Technetium	17-19	interleukin 1 beta	Homo sapiens	32-36
31323061-10	2019	IL1B and IL1RN expression was significantly higher in islets + DPS grafts.	dps	63-66	interleukin 1 beta	Homo sapiens	0-4
31213138-10	2019	Exogenous 15d-PGJ2 significantly reduced monocyte transmigration and exerted a pronounced anti-inflammatory effect on the transmigrated monocytes by downregulating, for example, transcription of the IL (interleukin)-1beta gene (IL1B).	15-deoxy-delta(12,14)-prostaglandin J2	10-18	interleukin 1 beta	Homo sapiens	228-232
31268709-10	2019	The ability of prenylated stilbenoids to attenuate the production of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was further evaluated using LPS-stimulated THP-1 macrophages.	Stilbenes	26-37	interleukin 1 beta	Homo sapiens	140-157
31357788-3	2019	Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis.	Ethanol	23-30	interleukin 1 beta	Homo sapiens	242-259
31357788-3	2019	Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis.	Uric Acid	63-72	interleukin 1 beta	Homo sapiens	242-259
31357788-3	2019	Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis.	Adenosine Triphosphate	78-100	interleukin 1 beta	Homo sapiens	242-259
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	interleukin 1 beta	Homo sapiens	154-171
31250861-3	2019	In addition, DPA also inhibited the abnormal production and mRNA expression of pro-inflammatory cytokines, namely tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 and improved the production and expression of an anti-inflammatory cytokine, IL-10.	docosapentaenoic acid	13-16	interleukin 1 beta	Homo sapiens	149-171
31300040-6	2019	RESULTS: In vitro, apabetalone prevented inflammatory (TNFalpha, LPS, or IL-1beta) induction of key factors that drive endothelial activation, monocyte recruitment, adhesion, and plaque destabilization.	apabetalone	19-30	interleukin 1 beta	Homo sapiens	73-81
31244012-5	2019	Anionic PEI-DGAs induce the secretion of proinflammatory cytokines IL-1beta, TNFalpha, and IL-6 in macrophages and MSCs, whereas cationic PEI-DGAs do not.	pei-dgas	8-16	interleukin 1 beta	Homo sapiens	67-75
31277614-7	2019	The potential for succinic acid to have anti-inflammatory effects was assessed by measuring the release of inflammatory cytokines IL-1alpha, IL-1beta, IL-8 and TNFalpha, and the inflammatory messenger PGE2, from THP-1 human macrophages after treatment with succinic acid and LPS.	Succinic Acid	18-31	interleukin 1 beta	Homo sapiens	141-149
31315822-4	2019	Exogenous H2S reduced the level of NLRP3, caspase-1, P62, IL-1beta and the ratio of P-mTOR/T-mTOR induced by OA and increased the ratio of LC3 II/I and the protein expression of Beclin1 suppressed by OA.	Hydrogen Sulfide	10-13	interleukin 1 beta	Homo sapiens	58-66
31214670-3	2019	Results showed that DHA effectively inhibited MSU-induced expression and secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells.	Docosahexaenoic Acids	20-23	interleukin 1 beta	Homo sapiens	86-103
31214670-3	2019	Results showed that DHA effectively inhibited MSU-induced expression and secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells.	Docosahexaenoic Acids	20-23	interleukin 1 beta	Homo sapiens	105-113
31214670-3	2019	Results showed that DHA effectively inhibited MSU-induced expression and secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells.	Uric Acid	46-49	interleukin 1 beta	Homo sapiens	86-103
31214670-3	2019	Results showed that DHA effectively inhibited MSU-induced expression and secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells.	Uric Acid	46-49	interleukin 1 beta	Homo sapiens	105-113
31311846-3	2019	Here, we demonstrated that the carbohydrate-binding protein galectin-3 stimulated microenvironment remodeling in the cornea by promoting the paracrine action of secreted interleukin-1beta (IL-1beta).	Carbohydrates	31-43	interleukin 1 beta	Homo sapiens	170-187
30953761-2	2019	Saturated fatty acids (SFAs) are sterile triggers able to induce the assembly of the NLRP3 inflammasome in macrophages, leading to IL-1beta secretion while unsaturated ones (UFAs) prevent SFAs-mediated NLRP3 activation.	Fatty Acids	0-21	interleukin 1 beta	Homo sapiens	131-139
30862504-3	2019	We report that in human primary articular chondrocytes, erythromycin, a well-known macrolide antibiotic, had the ability to inhibit pro-inflammatory cytokine Interleukin 1beta (IL-1beta)-induced catabolic gene expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation.	Erythromycin	56-68	interleukin 1 beta	Homo sapiens	158-175
30862504-3	2019	We report that in human primary articular chondrocytes, erythromycin, a well-known macrolide antibiotic, had the ability to inhibit pro-inflammatory cytokine Interleukin 1beta (IL-1beta)-induced catabolic gene expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation.	Macrolides	83-92	interleukin 1 beta	Homo sapiens	158-175
31360199-10	2019	Comparison of differences between pre- and 5-day post-treatment values confirmed that the upregulation of miR-223-3p and downregulation of IL-1beta induced by colchicine were more significant than etoricoxib (p &lt; 0.05).	Colchicine	159-169	interleukin 1 beta	Homo sapiens	139-147
31360199-12	2019	After 10-day treatment, the magnitude of miR-223-3p upregulation and IL-1beta downregulation in the colchicine group was significantly higher than in the etoricoxib group, while the etoricoxib group had higher expression of miR-451a and lower expression of COX-2 than the colchicine group (p &lt; 0.05).	Colchicine	100-110	interleukin 1 beta	Homo sapiens	69-77
31360199-14	2019	Colchicine could upregulate miR-223-3p and downregulate IL-1beta in the plasma, while etoricoxib may treat AGA by upregulating miR-451a and downregulating COX-2.	Colchicine	0-10	interleukin 1 beta	Homo sapiens	56-64
31304004-15	2019	By contrast, miR-150-5p depletion rescued the effect of MALAT1 downregulation or loss of AKT3 on IL-1beta-stimulated chondrocytes.	mir-150-5p	13-23	interleukin 1 beta	Homo sapiens	97-105
31004593-6	2019	Furthermore, knockdown of lnc-p21 mitigated MPP+-induced oxidative stress and neuroinflammation, as evidenced by the decrease in ROS generation, increase in SOD activity and decline in TNF-alpha, IL-1beta and IL-6 levels.	mangion-purified polysaccharide (Candida albicans)	44-48	interleukin 1 beta	Homo sapiens	196-204
31091351-6	2019	Moreover, heme itself stimulated significant Mphi pro-IL-1beta gene and protein expression via an S100A8-mediated mechanism and greatly amplified S100A8-driven NLRP3 inflammasome-mediated IL-1beta secretion.	Heme	10-14	interleukin 1 beta	Homo sapiens	50-62
31033505-3	2019	RECENT FINDINGS: The Canakinumab Anti-inflammatory Thrombosis Outcomes Study trial has provided convincing evidence that neutralization of the interleukin (IL)-1beta inflammatory pathway by the selective antibody canakinumab reduces major CVD events and significantly lowers IL-1beta, IL-6 and high-sensitivity C-reactive protein, without affecting low-density lipoprotein cholesterol levels.	density lipoprotein cholesterol	353-384	interleukin 1 beta	Homo sapiens	143-165
31030090-3	2019	In this study, our findings showed that ACD treatment could reduce the high lethality rate; decrease the serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), monocyte chemoattractant protein (MCP)-1, interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha), and ameliorate the pathological hepatic damage of ALF.	atractylodin	40-43	interleukin 1 beta	Homo sapiens	244-252
31266061-3	2019	We therefore examined the effect of EGCG on IL-1beta-induced collagen degradation by corneal fibroblasts embedded in a collagen gel.	epigallocatechin gallate	36-40	interleukin 1 beta	Homo sapiens	44-52
31266061-7	2019	Results: EGCG inhibited IL-1beta-induced, plasminogen-dependent collagen degradation by corneal fibroblasts in a concentration-dependent manner.	epigallocatechin gallate	9-13	interleukin 1 beta	Homo sapiens	24-32
31266061-9	2019	EGCG inhibited the IL-1beta-induced conversion of exogenous plasminogen to plasmin as well as the plasminogen-dependent activation of pro-MMP1 in the 3D cultures without a substantial effect on pro-MMP1 abundance.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	19-27
31266061-10	2019	Conclusions: EGCG inhibits IL-1beta-induced collagen degradation by corneal fibroblasts, with this effect likely being mediated by suppression of the upregulation of uPA, the uPA-mediated conversion of plasminogen to plasmin, and the plasmin-mediated activation of pro-MMP1.	epigallocatechin gallate	13-17	interleukin 1 beta	Homo sapiens	27-35
31028753-6	2019	With respect to cytokine inductions, APCs treated with either Sal-HA or Sal-M2e induced significantly (p &lt; .05) higher mRNA transcription levels of proinflammatory (IL-1beta, IL-6, IL-12 and IL-23), Th1 (IFN-gamma), Th17 (IL-17 and IL-21) and Th2 (IL-10 and TGF-beta) cytokines in T cells compared to Sal-NA or Salmonella alone treated APCs.	sal-ha	62-68	interleukin 1 beta	Homo sapiens	168-176
31028753-6	2019	With respect to cytokine inductions, APCs treated with either Sal-HA or Sal-M2e induced significantly (p &lt; .05) higher mRNA transcription levels of proinflammatory (IL-1beta, IL-6, IL-12 and IL-23), Th1 (IFN-gamma), Th17 (IL-17 and IL-21) and Th2 (IL-10 and TGF-beta) cytokines in T cells compared to Sal-NA or Salmonella alone treated APCs.	sal-m2e	72-79	interleukin 1 beta	Homo sapiens	168-176
30917625-10	2019	Caspase 1, which is responsible for IL-1beta production, was similarly induced by LPS and suppressed by TY52156.	1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl-2-butanone	104-111	interleukin 1 beta	Homo sapiens	36-44
31298304-11	2019	RESULTS: In the presence of high glucose, hRECs cells proliferation was significantly reduced, Caspase-3 activity was enhanced, LDH and ROS levels were increased, SOD activity was declined with increased expression of HMGB-1, NF-kappaB, VEGF, as well as secretion of TNF-alpha and IL-1beta compared with control group (p &lt; 0.05).	Glucose	33-40	interleukin 1 beta	Homo sapiens	281-289
31009895-7	2019	Besides, the expression of proinflammatory cytokines like IL-1beta and TNF-alpha as well as the excessive neuronal activity induced by CCI were suppressed by resveratrol.	Resveratrol	158-169	interleukin 1 beta	Homo sapiens	58-66
31030090-3	2019	In this study, our findings showed that ACD treatment could reduce the high lethality rate; decrease the serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), monocyte chemoattractant protein (MCP)-1, interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha), and ameliorate the pathological hepatic damage of ALF.	atractylodin	40-43	interleukin 1 beta	Homo sapiens	225-242
31274789-10	2019	The Dex group had significantly lower interleukin (IL)-1beta levels in the lung tissue compared to the other groups (p &lt; 0.05) and significantly lower IL-6 levels compared to the Ami and Mil groups (p &lt; 0.05).	Dexamethasone	4-7	interleukin 1 beta	Homo sapiens	38-60
31109954-9	2019	Using mass spectrometry and processing-site mutants of pro-IL-1beta, we identified D109 as a novel cleavage site of pro-IL-1beta in response to severe acidic stress and calculated the theoretical molecular mass of the mature form to be 18.2 kDa.	d109	83-87	interleukin 1 beta	Homo sapiens	55-67
31109954-9	2019	Using mass spectrometry and processing-site mutants of pro-IL-1beta, we identified D109 as a novel cleavage site of pro-IL-1beta in response to severe acidic stress and calculated the theoretical molecular mass of the mature form to be 18.2 kDa.	d109	83-87	interleukin 1 beta	Homo sapiens	116-128
31118224-3	2019	This study shows that complexed CRP (phosphocholine [PC]:CRP) (formed by binding of CRP to PC moieties), but not soluble CRP, synergized with specific TLRs to posttranscriptionally amplify TNF, IL-1beta, and IL-23 production by human inflammatory macrophages.	Phosphorylcholine	37-51	interleukin 1 beta	Homo sapiens	194-202
31234583-10	2019	Moreover, interleukin (IL)-1beta and vascular endothelial growth factor (VEGF) levels were reduced, and fewer von Willebrand factor (vWF)-stained areas were identified in the fullerenol-treated joints than in control joints.	fullerenol	175-185	interleukin 1 beta	Homo sapiens	10-32
30877511-4	2019	Our results showed that exogenous H2S reduced the protein levels of NLRP3, cleaved caspase-1, TLR4, NF-kappaB, P62, and IL-1beta induced by LPS + ATP and increased the ratio of LC3-II/I and the protein levels of Beclin 1 suppressed by LPS + ATP.	Hydrogen Sulfide	34-37	interleukin 1 beta	Homo sapiens	120-128
30877511-4	2019	Our results showed that exogenous H2S reduced the protein levels of NLRP3, cleaved caspase-1, TLR4, NF-kappaB, P62, and IL-1beta induced by LPS + ATP and increased the ratio of LC3-II/I and the protein levels of Beclin 1 suppressed by LPS + ATP.	Adenosine Triphosphate	146-149	interleukin 1 beta	Homo sapiens	120-128
31213577-5	2019	The IL-1beta-dependent up-regulation of inflammatory molecules including inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and IL-6 was attenuated by higenamine in NPCs.	Dinoprostone	150-154	interleukin 1 beta	Homo sapiens	4-12
31213577-5	2019	The IL-1beta-dependent up-regulation of inflammatory molecules including inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and IL-6 was attenuated by higenamine in NPCs.	higenamine	251-261	interleukin 1 beta	Homo sapiens	4-12
31213577-7	2019	Furthermore, we also found that higenamine suppressed the IL-1beta-induced activation of NF-kappaB signaling pathway in NPCs.	higenamine	32-42	interleukin 1 beta	Homo sapiens	58-66
31213577-8	2019	In conclusion, the present study proved that higenamine exhibited anti-inflammatory activity against IL-1beta-induced inflammation in NPCs via inhibiting NF-kappaB signaling pathway.	higenamine	45-55	interleukin 1 beta	Homo sapiens	101-109
31077718-12	2019	Similarly, 5-AzadC-treated OA synoviocytes showed decreased expression of IRAK-1, IL1Beta and IL-6, which was reversed following 5-AzadC-/miR-146a inhibitor treatment.	Decitabine	11-18	interleukin 1 beta	Homo sapiens	82-89
31077718-12	2019	Similarly, 5-AzadC-treated OA synoviocytes showed decreased expression of IRAK-1, IL1Beta and IL-6, which was reversed following 5-AzadC-/miR-146a inhibitor treatment.	Decitabine	129-136	interleukin 1 beta	Homo sapiens	82-89
31213577-0	2019	Higenamine inhibits IL-1beta-induced inflammation in human nucleus pulposus cells.	higenamine	0-10	interleukin 1 beta	Homo sapiens	20-28
31213577-4	2019	The results showed that higenamine improved cell viability in IL-1beta-induced NPCs.	higenamine	24-34	interleukin 1 beta	Homo sapiens	62-70
31213577-5	2019	The IL-1beta-dependent up-regulation of inflammatory molecules including inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and IL-6 was attenuated by higenamine in NPCs.	Nitric Oxide	83-95	interleukin 1 beta	Homo sapiens	4-12
31213577-5	2019	The IL-1beta-dependent up-regulation of inflammatory molecules including inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and IL-6 was attenuated by higenamine in NPCs.	Dinoprostone	132-148	interleukin 1 beta	Homo sapiens	4-12
31341381-12	2019	Selective inhibition of COX2 activity decreased osmotic expression of the VEGFA, IL1B, and NLRP3 genes, and blocked the NaCl-induced increase in the cytosolic IL-1beta level.	Sodium Chloride	120-124	interleukin 1 beta	Homo sapiens	159-167
31036319-9	2019	Besides, cell apoptosis rate, CD31-positive EMPs amount, TNF-alpha and IL-1beta concentrates, and ROCK II mRNA and protein levels in LPS + TMP group were significantly decreased when compared with LPS group.	tetramethylpyrazine	139-142	interleukin 1 beta	Homo sapiens	71-79
31281309-5	2019	The treatment of macrophages with PDL-sup, but not PDL-sup from unstimulated PDL cells, inhibited the production of IL-1beta in LPS/nigericin-stimulated macrophages.	Nigericin	132-141	interleukin 1 beta	Homo sapiens	116-124
31281309-9	2019	Purified exosomes inhibited IL-1beta production in LPS/nigericin-stimulated macrophages and the nuclear translocation of NF-kappaB as well as NF-kappaB p65 DNA-binding activity in LPS-stimulated macrophages, suggesting that exosomes suppress IL-1beta production by inhibiting the NF-kappaB signaling pathway.	Nigericin	55-64	interleukin 1 beta	Homo sapiens	28-36
31205026-5	2019	Specifically, FLC-mediated production of H2O2 was shown to activate JAK2/STAT1 signaling, increase production of IL-1beta via induction of capsase-1, and promote activation of TGF-beta via alphavbeta6 integrin.	Hydrogen Peroxide	41-45	interleukin 1 beta	Homo sapiens	113-121
31354329-3	2019	We and others have shown that high glucose can activate the NOD-like receptor family, pyrin domain containing family member 3 (NLRP3) pathway, leading to increased levels of cleaved caspase 1 and IL-1beta to activate a number of inflammatory pathways in the retina.	Glucose	35-42	interleukin 1 beta	Homo sapiens	196-204
31212975-3	2019	The present study explored whether quercetin can inhibit the interleukin-1beta (IL-1beta)-induced production of inflammatory cytokines and chemokines in ARPE-19 cells.	Quercetin	35-44	interleukin 1 beta	Homo sapiens	61-78
31198003-13	2019	Furthermore, after 4-PBA inhibiting ERS, the expressions of GRP78, CHOP, IL-1beta, TNF-alpha, and P65 were significantly decreased ( P&lt;0.05), and flow cytometry results showed that cell apoptotic rate in smoking group was decreased, showing significant difference compared with the non-smoking group ( P&lt;0.05).	4-phenylbutylamine	19-24	interleukin 1 beta	Homo sapiens	73-81
31174565-10	2019	Moreover, H. cordata and 2-undecanone effectively decreased B[a]P-induced intracellular reactive oxygen species (ROS) overproduction and further notably protected BEAS.2B cells from B[a]P-induced DNA damage and inflammation by significantly inhibiting phosphorylated H2A.X overexpression and interleukin-1beta secretion.	undecan-2-one	25-37	interleukin 1 beta	Homo sapiens	292-309
31174565-10	2019	Moreover, H. cordata and 2-undecanone effectively decreased B[a]P-induced intracellular reactive oxygen species (ROS) overproduction and further notably protected BEAS.2B cells from B[a]P-induced DNA damage and inflammation by significantly inhibiting phosphorylated H2A.X overexpression and interleukin-1beta secretion.	Phosphorus	64-65	interleukin 1 beta	Homo sapiens	292-309
31231223-3	2019	Herein, we compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1beta-induced A549 lung cancer cells using mass spectrometry.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	115-121	interleukin 1 beta	Homo sapiens	155-177
31231214-6	2019	Moreover, immunohistochemistry and enzyme-linked immunosorbent assays showed that DAC reduced the release of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in vivo.	deacylcynaropicrin	82-85	interleukin 1 beta	Homo sapiens	138-160
31244838-10	2019	Methods and Results: Serum starvation selectively reduced LPS/ATP-induced IL-1beta secretion from cardiac fibroblasts.	Adenosine Triphosphate	62-65	interleukin 1 beta	Homo sapiens	74-82
31244838-12	2019	The mTOR inhibitor rapamycin restored pro-IL-1beta protein levels as well as LPS/ATP-induced IL-1beta release from serum starved cells.	Sirolimus	19-28	interleukin 1 beta	Homo sapiens	38-50
31244838-3	2019	If tissue damage occurs, danger signals released from necrotic cells, such as ATP, can activate NLRP3-inflammasomes (multiprotein complexes consisting of NLRP3, ASC, and active caspase-1) which cleaves and activates pro-IL-1beta.	Adenosine Triphosphate	78-81	interleukin 1 beta	Homo sapiens	220-228
31244838-12	2019	The mTOR inhibitor rapamycin restored pro-IL-1beta protein levels as well as LPS/ATP-induced IL-1beta release from serum starved cells.	Sirolimus	19-28	interleukin 1 beta	Homo sapiens	42-50
31244838-14	2019	Conversely, chloroquine and bafilomycin A (inhibitors of autophagy) and betulinic acid (a proteasome activator) effectively reduced LPS-induced pro-IL-1beta protein levels.	Chloroquine	12-23	interleukin 1 beta	Homo sapiens	144-156
31244838-14	2019	Conversely, chloroquine and bafilomycin A (inhibitors of autophagy) and betulinic acid (a proteasome activator) effectively reduced LPS-induced pro-IL-1beta protein levels.	bafilomycin A	28-41	interleukin 1 beta	Homo sapiens	144-156
30851273-12	2019	Inhibition of PP2A significantly restored NLRP3 and pro-IL-1beta protein expression level downregulated by metformin in ox-LDL-stimulated macrophages.	Metformin	107-116	interleukin 1 beta	Homo sapiens	52-64
31244838-14	2019	Conversely, chloroquine and bafilomycin A (inhibitors of autophagy) and betulinic acid (a proteasome activator) effectively reduced LPS-induced pro-IL-1beta protein levels.	betulinic acid	72-86	interleukin 1 beta	Homo sapiens	144-156
30753544-6	2019	At a functional level, metformin lowered ex vivo production of tumor necrosis factor alpha, interferon gamma, and interleukin 1beta but increased phagocytosis activity and reactive oxygen species production.	Metformin	23-32	interleukin 1 beta	Homo sapiens	114-131
30982734-0	2019	Choline Uptake and Metabolism Modulate Macrophage IL-1beta and IL-18 Production.	Choline	0-7	interleukin 1 beta	Homo sapiens	50-58
30982734-3	2019	Inhibition of CTL1 expression or choline phosphorylation attenuated NLRP3 inflammasome activation and IL-1beta and IL-18 production in stimulated macrophages.	Choline	33-40	interleukin 1 beta	Homo sapiens	102-110
31166413-11	2019	TEGDMA reduced the bacterial-induced release of IL-1beta and TNF-alpha, whereas UDMA reduced IL-1beta release (p&lt;0.05).	triethylene glycol dimethacrylate	0-6	interleukin 1 beta	Homo sapiens	48-56
31146818-7	2019	Upon exposure of ECs to e-liquid, conditioned media induced macrophage polarization into a pro-inflammatory state, eliciting the production of interleukin-1beta and -6, leading to increased ROS.	Reactive Oxygen Species	190-193	interleukin 1 beta	Homo sapiens	143-167
31167479-6	2019	1,2-DHX decreased THP-1 secretion of interleukin-1beta (IL-1beta) and interleukin-10 (IL-10), but stimulated tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) production.	1,2-dhx	0-7	interleukin 1 beta	Homo sapiens	37-54
31167479-6	2019	1,2-DHX decreased THP-1 secretion of interleukin-1beta (IL-1beta) and interleukin-10 (IL-10), but stimulated tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) production.	1,2-dhx	0-7	interleukin 1 beta	Homo sapiens	56-64
30958608-7	2019	In addition, DEX suppressed the generation of TNF-alpha, IL-1beta, and IL-18 as well as the phosphorylation of ERK1/2 and P38.	Dexmedetomidine	13-16	interleukin 1 beta	Homo sapiens	57-65
29925283-6	2019	The suppression of inflammation by testosterone were observed in patients with coronary artery disease, prostate cancer and diabetes mellitus through the increase in anti-inflammatory cytokines (IL-10) and the decrease in pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha).	Testosterone	35-47	interleukin 1 beta	Homo sapiens	250-258
31360100-5	2019	We found that caffeine significantly reduced NLRP3 expression, ASC speck formation, and caspase 1 cleavage and therefore decreased IL-1beta and IL-18 secretion in THP-1 macrophages.	Caffeine	14-22	interleukin 1 beta	Homo sapiens	131-139
30879690-4	2019	Secretion of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha (254.7 pg/mL, 2.5 ng/mL, and 42.9 pg/mL, respectively) was significantly induced by NFG.	2,4-Dinitrophenyl 2-Deoxy-2-Fluoro-Beta-D-Glucopyranoside	163-166	interleukin 1 beta	Homo sapiens	28-45
31078522-5	2019	Chemoproteomics of 4-PBA-treated and untreated EBS cells revealed reduced IL1beta expression- but also showed activation of Wnt/beta-catenin and NF-kB pathways.	4-phenylbutyric acid	19-24	interleukin 1 beta	Homo sapiens	74-81
30360657-5	2019	RESULTS: The halogen light group showed significantly more DNA damage, higher TNF-alpha, IL-1beta, and IL-6 levels, and lower viable cell count at 30 min compared to the control group.	Halogens	13-20	interleukin 1 beta	Homo sapiens	89-97
31101589-6	2019	Rifamycin also antagonized TNFalpha and LPS-induced NFkappaB activities and inhibited IL1beta-induced synthesis of inflammatory chemokine, IL8.	rifamycin SV	0-9	interleukin 1 beta	Homo sapiens	86-93
30835936-6	2019	Finally, for verifying the accuracy of microarray analysis, qRT-PCR was used to analyze the transcription level of key genes in the above signaling pathways, and ELISA assay confirmed the effect of TBBPA on the levels of CXCL-2, CCL-3, CCL-4, IL-1beta, TNF-alpha, and IL-6.	tetrabromobisphenol A	198-203	interleukin 1 beta	Homo sapiens	243-251
31026357-1	2019	A causal relationship exists between macrophage cholesterol levels and inflammation, for example, Interleukin-1beta (IL-1beta) secretion.	Cholesterol	48-59	interleukin 1 beta	Homo sapiens	98-115
31010371-7	2019	This could be validated by experiments showing that phagocytosis of mycobacteria, which is an event preceding mycobacteria-induced IL-1beta production, was strongly correlated with the DMG pattern.	dimethylglycine	185-188	interleukin 1 beta	Homo sapiens	131-139
31026357-1	2019	A causal relationship exists between macrophage cholesterol levels and inflammation, for example, Interleukin-1beta (IL-1beta) secretion.	Cholesterol	48-59	interleukin 1 beta	Homo sapiens	117-125
31026357-4	2019	Enhancing cholesterol efflux returned K+ currents back to basal levels with corresponding increase in intracellular K+ (11.2-14.5%) and reduced IL-1beta secretion (32-62%).	Cholesterol	10-21	interleukin 1 beta	Homo sapiens	144-152
31026357-6	2019	Attenuation of IL-1beta secretion by Nateglinide/Repaglinide further suggests involvement of Kir6 channels.	Nateglinide	37-48	interleukin 1 beta	Homo sapiens	15-23
31026357-6	2019	Attenuation of IL-1beta secretion by Nateglinide/Repaglinide further suggests involvement of Kir6 channels.	repaglinide	49-60	interleukin 1 beta	Homo sapiens	15-23
30565030-0	2019	Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1beta-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative.	Chalcone	163-186	interleukin 1 beta	Homo sapiens	109-117
30907046-10	2019	Increased intracellular ROS resulted in nuclear factor kappa B (NF-kappaB) activation and upregulated expression of cyclooxygenase-2 (COX-2), hemeoxygenase-1 (HO-1), interleukin-1beta (IL-1beta), and intercellular adhesion molecule-1 (ICAM-1).	Reactive Oxygen Species	24-27	interleukin 1 beta	Homo sapiens	166-183
30907046-10	2019	Increased intracellular ROS resulted in nuclear factor kappa B (NF-kappaB) activation and upregulated expression of cyclooxygenase-2 (COX-2), hemeoxygenase-1 (HO-1), interleukin-1beta (IL-1beta), and intercellular adhesion molecule-1 (ICAM-1).	Reactive Oxygen Species	24-27	interleukin 1 beta	Homo sapiens	185-193
30659877-5	2019	In addition, LRWXG can significantly reduce the levels of inflammatory-related factors such as COX2, PEG2, TNFalpha and IL1beta, and inhibits the expression of MMPs, increasing the content of type II collagen.	lrwxg	13-18	interleukin 1 beta	Homo sapiens	120-127
30903650-6	2019	After stimulation with IL-1beta or fibronectin fragments, we showed that ERK inhibition decreased Runx2 activation and ADAMTS-12 expression in OA-SF, also reducing Fn-fs-induced COMP degradation.	Fenofibrate	164-169	interleukin 1 beta	Homo sapiens	23-31
30901677-7	2019	Moreover, Genistein treatment down-regulated production of caspase-1 and IL-1beta and increased intracellular cAMP level, which were similar to the treatment for INT-777, a semi-synthetic TGR5 agonist, in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells and U937 cells.	Genistein	10-19	interleukin 1 beta	Homo sapiens	73-81
31108534-0	2019	Relationship of Interleukin-1beta Blockade With Incident Gout and Serum Uric Acid Levels.	Uric Acid	72-81	interleukin 1 beta	Homo sapiens	16-33
29385859-1	2019	OBJECTIVE: Previous studies have indicated that the nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3) inflammasome is activated by monosodium urate in the trophoblast of preeclampsia (PE) patients, leading to augmented placental IL-1beta levels.	Uric Acid	157-173	interleukin 1 beta	Homo sapiens	255-263
31048784-0	2019	Choline uptake is vital for IL-1beta-driven inflammation.	Choline	0-7	interleukin 1 beta	Homo sapiens	28-36
30849398-6	2019	This effect may occur through CARV anti-inflammatory and antioxidant properties, as the pretreatment with CARV/beta-CD inhibited the release of IL-1beta and TNF-alpha; besides, CARV prevented the increase of mitochondrial superoxide production induced by 6-OHDA in cultured SH-SY5Y cells.	carvacrol	106-110	interleukin 1 beta	Homo sapiens	144-152
30849398-6	2019	This effect may occur through CARV anti-inflammatory and antioxidant properties, as the pretreatment with CARV/beta-CD inhibited the release of IL-1beta and TNF-alpha; besides, CARV prevented the increase of mitochondrial superoxide production induced by 6-OHDA in cultured SH-SY5Y cells.	betadex	111-118	interleukin 1 beta	Homo sapiens	144-152
30849398-6	2019	This effect may occur through CARV anti-inflammatory and antioxidant properties, as the pretreatment with CARV/beta-CD inhibited the release of IL-1beta and TNF-alpha; besides, CARV prevented the increase of mitochondrial superoxide production induced by 6-OHDA in cultured SH-SY5Y cells.	carvacrol	106-110	interleukin 1 beta	Homo sapiens	144-152
31359734-16	2019	The results showed that Fuyanshu Capsules combined with levofloxacin and metronidazole could alleviate the clinical symptoms and signs of chronic pelvic inflammation of damp-heat stagnation type,reduce the recurrence rate of pelvic inflammation,relieve pelvic pain,and alleviate the inflammation status of patients by regulating the expression of IL-10 and IL-1beta in peripheral serum.	Levofloxacin	56-68	interleukin 1 beta	Homo sapiens	357-365
31359734-16	2019	The results showed that Fuyanshu Capsules combined with levofloxacin and metronidazole could alleviate the clinical symptoms and signs of chronic pelvic inflammation of damp-heat stagnation type,reduce the recurrence rate of pelvic inflammation,relieve pelvic pain,and alleviate the inflammation status of patients by regulating the expression of IL-10 and IL-1beta in peripheral serum.	Metronidazole	73-86	interleukin 1 beta	Homo sapiens	357-365
31142341-3	2019	The severity of HIE in infants is tightly associated with increased IL-1beta expression and astrocyte activation which was regulated by transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel in the TRP family.	Tryptophan	178-181	interleukin 1 beta	Homo sapiens	68-76
31137797-2	2019	This compound has anti-inflammatory, anti-oxidative, and anti-cancer effects; however, the mechanism underlying the effects of genistein on IL-1beta-stimulated human osteoarthritis (OA) chondrocytes remains unknown.	Genistein	127-136	interleukin 1 beta	Homo sapiens	140-148
31137797-3	2019	Our objectives in this study were to explore the anti-inflammatory effects of genistein on IL-1beta-stimulated human OA chondrocytes and to investigate the potential mechanisms which underlie them.	Genistein	78-87	interleukin 1 beta	Homo sapiens	91-99
31137797-4	2019	Our results from an in-vitro model of osteoarthritis indicate that genistein inhibits the IL-1beta-induced expression of the catabolic factors nitric oxide synthase 2 (NOS2), cyclooxygenase 2 (COX-2), and matrix metalloproteinases (MMPs).	Genistein	67-76	interleukin 1 beta	Homo sapiens	90-98
31130634-4	2019	To deepen the modulatory effects of these molecules we studied: i) their influence on the synthesis of proinflammatory molecules (PGE2, IL-8, IL-6, MCP-1, and ICAM-1) in IL-1beta-treated myofibroblasts of the colon CCD-18Co cell line, and ii) the inhibitory potential of the formation of advanced glycation end products (AGEs).	Dinoprostone	130-134	interleukin 1 beta	Homo sapiens	170-178
30959169-9	2019	Moreover, caspase-1 activity and IL-1beta production were increased in ECs stimulated with oxLDL, ATP or UTP through the modulation of mtROS production and mtDNA expression, in a P2Y2R-dependent manner.	Adenosine Triphosphate	98-101	interleukin 1 beta	Homo sapiens	33-41
30959169-9	2019	Moreover, caspase-1 activity and IL-1beta production were increased in ECs stimulated with oxLDL, ATP or UTP through the modulation of mtROS production and mtDNA expression, in a P2Y2R-dependent manner.	Uridine Triphosphate	105-108	interleukin 1 beta	Homo sapiens	33-41
30959169-11	2019	Taken together, our findings suggest that P2Y2R activation by ATP is involved in oxLDL-mediated inflammasome activation and subsequent IL-1beta production through the modulation of mtROS-mtDNA induction and the TLR9-NF-kappaB signaling pathway.	Adenosine Triphosphate	62-65	interleukin 1 beta	Homo sapiens	135-143
31164964-0	2019	H2S mediates increased interleukin (IL)-1beta and IL-18 production in leukocytes from patients with periodontitis.	Hydrogen Sulfide	0-3	interleukin 1 beta	Homo sapiens	23-45
31164964-2	2019	Aim: To investigate the effect of the bacterial metabolite H2S on the pro-inflammatory cytokines interleukin (IL)-1beta and IL-18 from periodontitis patients and healthy controls, and to evaluate the composition of the subgingival microbiota with its capacity to produce H2S.	Hydrogen Sulfide	59-62	interleukin 1 beta	Homo sapiens	97-119
31164964-6	2019	PBMCs exposed to H2S secreted significantly more IL-1ss and IL-18 (p&lt;0.0001) than untreated control PBMCs from both groups.	Hydrogen Sulfide	17-20	interleukin 1 beta	Homo sapiens	49-53
31164964-7	2019	PBMCs from the periodontitis patients secreted higher levels of the cytokines, both spontaneously (IL-1ss p=0.0001; IL-18 p=0.09) and after exposure to H2S (IL-1ss p=0.03; IL-18 p=0.04), which is a new finding not previously reported.	Hydrogen Sulfide	152-155	interleukin 1 beta	Homo sapiens	99-103
31164964-7	2019	PBMCs from the periodontitis patients secreted higher levels of the cytokines, both spontaneously (IL-1ss p=0.0001; IL-18 p=0.09) and after exposure to H2S (IL-1ss p=0.03; IL-18 p=0.04), which is a new finding not previously reported.	Hydrogen Sulfide	152-155	interleukin 1 beta	Homo sapiens	116-120
31164964-8	2019	Conclusions: H2S, from the subgingival microbiota, can contribute to a host inflammatory response through secretion of the pro-inflammatory cytokines IL-1beta and IL-18.	Hydrogen Sulfide	13-16	interleukin 1 beta	Homo sapiens	150-158
31106772-8	2019	A number of cytokines such as hepatocyte growth factor (HGF), interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) regulate the homeostasis of bile acids.	Bile Acids and Salts	163-173	interleukin 1 beta	Homo sapiens	62-79
31118410-5	2019	We further found that sustained treatment with the AMPK activator 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR), but not the AMPK inhibitor Compound C, significantly alleviated UA-induced reductions in NKA activity and NKA alpha1 subunit expression on the cell membrane by reducing NKA degradation in lysosomes; sustained AICAR treatment also significantly alleviated activation of the NKA downstream molecules Src and interleukin-1beta (IL-1beta) in PTECs.	acadesine	66-120	interleukin 1 beta	Homo sapiens	436-453
30639312-6	2019	Saxagliptin treatment reduces ox-LDL-induced production of cytokines and vascular adhesion molecules including tumor necrosis factor (TNF-alpha), interleukin-1beta (IL-1beta), vascular cell adhesion molecule 1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1).	saxagliptin	0-11	interleukin 1 beta	Homo sapiens	146-163
30639312-6	2019	Saxagliptin treatment reduces ox-LDL-induced production of cytokines and vascular adhesion molecules including tumor necrosis factor (TNF-alpha), interleukin-1beta (IL-1beta), vascular cell adhesion molecule 1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1).	saxagliptin	0-11	interleukin 1 beta	Homo sapiens	165-173
31118410-5	2019	We further found that sustained treatment with the AMPK activator 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR), but not the AMPK inhibitor Compound C, significantly alleviated UA-induced reductions in NKA activity and NKA alpha1 subunit expression on the cell membrane by reducing NKA degradation in lysosomes; sustained AICAR treatment also significantly alleviated activation of the NKA downstream molecules Src and interleukin-1beta (IL-1beta) in PTECs.	acadesine	122-127	interleukin 1 beta	Homo sapiens	436-453
31095595-8	2019	Our analyses demonstrated that IL-1b, IL-2, IL-4 and IL-6 were significantly stimulated as a function of urinary arsenic levels in models adjusted for age, body mass index (BMI), smoking status and PAH-DNA adducts.	Arsenic	113-120	interleukin 1 beta	Homo sapiens	31-36
31095595-10	2019	We found a U-shaped dose response relationship between urinary arsenic and IL-1b.	Arsenic	63-70	interleukin 1 beta	Homo sapiens	75-80
31106772-8	2019	A number of cytokines such as hepatocyte growth factor (HGF), interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) regulate the homeostasis of bile acids.	Bile Acids and Salts	163-173	interleukin 1 beta	Homo sapiens	81-89
31139184-3	2019	Pretreatment of human RASFs with JWH-015 (10-20 muM) markedly inhibited the ability of pro-inflammatory cytokine interleukin-1beta (IL-1beta) to induce production of IL-6 and IL-8 and cellular expression of inflammatory cyclooxygenase-2 (COX-2).	JHW 015	33-40	interleukin 1 beta	Homo sapiens	113-130
30742923-0	2019	Circular RNA circPTK2 regulates oxygen-glucose deprivation-activated microglia-induced hippocampal neuronal apoptosis via miR-29b-SOCS-1-JAK2/STAT3-IL-1beta signaling.	oxygen-glucose	32-46	interleukin 1 beta	Homo sapiens	148-156
31259292-5	2019	Central catecholamines stimulate the release of IL-1beta from microglia, which is a key factor in the further activation of microglia and recruitment of monocytes into the brain.	Catecholamines	8-22	interleukin 1 beta	Homo sapiens	48-56
31139563-0	2019	Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1beta and IL-18 Release.	Berberine	21-30	interleukin 1 beta	Homo sapiens	81-89
31139563-6	2019	In this study, we demonstrate that berberine significantly inhibits inflammatory cytokine Caspase-1 activation via ERK1/2 signaling and subsequent production of IL-1beta and IL-18 by glioma cells.	Berberine	35-44	interleukin 1 beta	Homo sapiens	161-169
31334440-4	2019	In active drinkers, quantitative real-time polymerase chain reaction revealed alcohol-induced activation of tumor necrosis factor alpha, interleukin (IL)-1beta, and nuclear factor kappa B in liver tissue already at early disease stages.	Alcohols	78-85	interleukin 1 beta	Homo sapiens	137-159
31190939-10	2019	Both polyols suppressed the expression of IL-1alpha but only glycerol decreased the expression of IL-1beta and NFAT5.	Glycerol	61-69	interleukin 1 beta	Homo sapiens	98-106
31139184-3	2019	Pretreatment of human RASFs with JWH-015 (10-20 muM) markedly inhibited the ability of pro-inflammatory cytokine interleukin-1beta (IL-1beta) to induce production of IL-6 and IL-8 and cellular expression of inflammatory cyclooxygenase-2 (COX-2).	JHW 015	33-40	interleukin 1 beta	Homo sapiens	132-140
31139184-4	2019	JWH-015 was effective in reducing IL-1beta-induced phosphorylation of TAK1 (Thr184/187) and JNK/SAPK in human RASFs.	JHW 015	0-7	interleukin 1 beta	Homo sapiens	34-42
31123414-12	2019	Knockdown of MALAT1 increased the viability of PA-treated cardiomyocytes, decreased apoptosis, and reduced the levels of LDH, CK-MB, TNF-alpha, and IL-1beta.	Palmitic Acid	47-49	interleukin 1 beta	Homo sapiens	148-156
30771382-7	2019	Moreover, ceramide in podocytes was found elevated upon d-ribose stimulation, and prior treatments of podocyte with acid sphingomyelinase (Asm) inhibitor, amitriptyline, acid ceramidase (AC) inducer, genistein, or AC CRISPR/cas9 activation plasmids were found to decrease d-ribose-induced ceramide accumulation, EVs release and IL-1beta secretion due to reduced interactions of lysosome with MVBs.	Ceramides	10-18	interleukin 1 beta	Homo sapiens	328-336
31139332-10	2019	Our results suggest that the modulation of cell adhesion and suppression of IL-1beta induced inflammation may underlie the efficacy of ECP in L-CTCL.	l-ctcl	142-148	interleukin 1 beta	Homo sapiens	76-84
29232287-5	2019	RESULTS: IL-1beta levels increased significantly in cells treated with high dextrose; however, IL-6 and IL-8 levels did not change.	Glucose	76-84	interleukin 1 beta	Homo sapiens	9-17
29232287-7	2019	Similar effects on IL-1beta, IL-6, and IL-8 levels were observed when cells were treated with simvastatin, pravastatin, and the renin-angiotensin system inhibitors spironolactone, captopril, lisinopril, candesartan, and losartan.	Simvastatin	94-105	interleukin 1 beta	Homo sapiens	19-27
30771382-3	2019	In this study, we hypothesized that the NLRP3 inflammasome product, IL-1beta in response to exogenously administrated and endogenously produced d-ribose stimulation is released via extracellular vesicles including EVs via a sphingolipid-mediated molecular mechanisms controlling lysosome and multivesicular body (MVB) interaction.	Ribose	144-152	interleukin 1 beta	Homo sapiens	68-76
30771382-8	2019	These results suggest that inflammasome-derived products such as IL-1beta during d-ribose stimulation are released via EVs, in which lysosomal sphingolipid-mediated regulation of lysosome function plays an important role.	Ribose	81-89	interleukin 1 beta	Homo sapiens	65-73
30771382-3	2019	In this study, we hypothesized that the NLRP3 inflammasome product, IL-1beta in response to exogenously administrated and endogenously produced d-ribose stimulation is released via extracellular vesicles including EVs via a sphingolipid-mediated molecular mechanisms controlling lysosome and multivesicular body (MVB) interaction.	EVS	214-217	interleukin 1 beta	Homo sapiens	68-76
30771382-3	2019	In this study, we hypothesized that the NLRP3 inflammasome product, IL-1beta in response to exogenously administrated and endogenously produced d-ribose stimulation is released via extracellular vesicles including EVs via a sphingolipid-mediated molecular mechanisms controlling lysosome and multivesicular body (MVB) interaction.	Sphingolipids	224-236	interleukin 1 beta	Homo sapiens	68-76
30771382-8	2019	These results suggest that inflammasome-derived products such as IL-1beta during d-ribose stimulation are released via EVs, in which lysosomal sphingolipid-mediated regulation of lysosome function plays an important role.	EVS	119-122	interleukin 1 beta	Homo sapiens	65-73
30771382-4	2019	First, we demonstrated that both endogenous and exogenous d-ribose induced NLRP3 inflammasome activation to produce IL-1beta, which was released via EVs in podocytes.	Ribose	58-66	interleukin 1 beta	Homo sapiens	116-124
30771382-8	2019	These results suggest that inflammasome-derived products such as IL-1beta during d-ribose stimulation are released via EVs, in which lysosomal sphingolipid-mediated regulation of lysosome function plays an important role.	Sphingolipids	143-155	interleukin 1 beta	Homo sapiens	65-73
30771382-4	2019	First, we demonstrated that both endogenous and exogenous d-ribose induced NLRP3 inflammasome activation to produce IL-1beta, which was released via EVs in podocytes.	EVS	149-152	interleukin 1 beta	Homo sapiens	116-124
30771382-5	2019	Then, we found that colocalization of marker MVB marker VPS16 with IL-1beta within podocytes increased upon d-ribose stimulation, which was accompanied by decreased colocalization of lysosome marker Lamp-1 and VPS16, suggesting decrease in MVB inclusion of IL-1beta due to reduced lysosome and MVB interaction.	Ribose	108-116	interleukin 1 beta	Homo sapiens	67-75
30771382-5	2019	Then, we found that colocalization of marker MVB marker VPS16 with IL-1beta within podocytes increased upon d-ribose stimulation, which was accompanied by decreased colocalization of lysosome marker Lamp-1 and VPS16, suggesting decrease in MVB inclusion of IL-1beta due to reduced lysosome and MVB interaction.	Ribose	108-116	interleukin 1 beta	Homo sapiens	257-265
31934009-5	2019	Pearson correlation analysis showed that the serum 25(OH)D level in patients with T2DM had a negative correlation with HOMA-IR (r=-0.750, P&lt;0.001), TNF-alpha (r=-0.705, P&lt;0.001), IL-1beta (r=-0.661, P&lt;0.001), IL-8 (r=-0.645, P&lt;0.001), and IL-6 (r=-0.609, P&lt;0.001).	25-hydroxyvitamin D3-bromoacetate	51-58	interleukin 1 beta	Homo sapiens	185-193
30851700-10	2019	Serum IL-1beta (p = 0.008) and interferon (IFN)-gamma (p = 0.007) levels tended to be higher in patients with AE-IPF than in those with S-IPF.	ae-ipf	110-116	interleukin 1 beta	Homo sapiens	6-14
30962589-6	2019	In monocytes, formation of GSDMD pores can induce activation of the NLRP3 inflammasome for maturation of the cytokines IL-1beta and IL-18.	gsdmd	27-32	interleukin 1 beta	Homo sapiens	119-127
30851700-10	2019	Serum IL-1beta (p = 0.008) and interferon (IFN)-gamma (p = 0.007) levels tended to be higher in patients with AE-IPF than in those with S-IPF.	s-ipf	136-141	interleukin 1 beta	Homo sapiens	6-14
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	interleukin 1 beta	Homo sapiens	119-127
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	Iron	15-19	interleukin 1 beta	Homo sapiens	203-211
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	ferric ammonium citrate	21-44	interleukin 1 beta	Homo sapiens	119-127
30835899-4	2019	Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry.	ferric ammonium citrate	21-44	interleukin 1 beta	Homo sapiens	203-211
30835899-11	2019	Furthermore, NAFLD patients with hepatic RES iron deposition had increased hepatic gene expression levels of M1 markers, IL-6, IL-1beta, and CD40 and reduced gene expression of an M2 marker, TGM2, relative to patients with hepatocellular iron deposition pattern.	Iron	45-49	interleukin 1 beta	Homo sapiens	127-135
30753845-8	2019	In PBMCs, exposure to these steroids resulted in the increase of mRNA and secreted protein levels of IL-1beta, TNFalpha, and IL-6 cytokines, as well as in the increase of INFgamma mRNA level, decrease of IL-2 mRNA level, increase of TGFbeta mRNA level, and decrease of IL-4 mRNA and IL-10 secreted protein levels.	Steroids	28-36	interleukin 1 beta	Homo sapiens	101-109
30900284-2	2019	METHODS: To study the role of IL-1beta expression in prostate inflammation, we examined IL1B expression in human prostatic proliferative inflammatory atrophy (PIA) lesions and developed a tetracycline-regulated human IL1B transgene in the mouse prostate.	Tetracycline	188-200	interleukin 1 beta	Homo sapiens	217-221
30900284-2	2019	METHODS: To study the role of IL-1beta expression in prostate inflammation, we examined IL1B expression in human prostatic proliferative inflammatory atrophy (PIA) lesions and developed a tetracycline-regulated human IL1B transgene in the mouse prostate.	Tetracycline	188-200	interleukin 1 beta	Homo sapiens	30-38
31039752-6	2019	Macrophages from persons with previous EPTB had a 38.88 mug/mL increase in median IL-1beta production after stimulation with LpqH compared to uninfected contacts (P = 0.01); the effect was similar (44.99 mug/mL) but not statistically significant after controlling for foreign-born status.	lpqh	125-129	interleukin 1 beta	Homo sapiens	82-90
31008484-5	2019	The results showed that, PGE2 increased interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) output, decreased chemokine (c-x-c motif) ligand 8 (CXCL8) output in a dose-dependent manner, but had no effect on IL-1beta and chemokine (c-c motif) ligand 2 (CCL-2) secretion of HUSMCs.	Dinoprostone	25-29	interleukin 1 beta	Homo sapiens	219-227
31068292-6	2019	Compared with the patients with UAP, the patients with AMI had significantly higher plasma IL-1beta and hs-CRP levels (P &amp;lt; 0.001 and P &amp;lt; 0.01) but lower expression levels of Cx43 in the PBMCs (P &amp;lt; 0.05).	Adenosine Monophosphate	122-125	interleukin 1 beta	Homo sapiens	91-99
31105691-5	2019	DAPT also inhibited the contact-dependent induction of CXCL8, but not of CCL5, in TNFalpha- and IL-1beta-stimulated TNBC:MSC/CAF co-cultures; some level of heterogeneity between the responses of different TNBC cell lines was noted, with MDA-MB-231:MSC/CAF co-cultures being the most sensitive to DAPT.	dapt	0-4	interleukin 1 beta	Homo sapiens	96-104
31027151-5	2019	Adsorption of serum proteins, and BSA on MSU, as well as upon m-CPPD crystals, inhibited their capacity to induce interleukin-1-beta secretions, along with a decreased ATP secretion, and a disturbance of mitochondrial membrane depolarization, suggesting an alteration of NLRP3 inflammasome activation.	m-cppd	62-68	interleukin 1 beta	Homo sapiens	114-132
31008484-6	2019	EP1/EP3 agonist 17-phenyl-trinor-PGE2 stimulated IL-6 and TNFalpha whilst suppressing IL-1beta and CXCL8 output.	17-phenyltrinorprostaglandin E2	16-37	interleukin 1 beta	Homo sapiens	86-94
31008484-7	2019	The effects of 17-phenyl-trinor-PGE2 on IL-1beta and CXCL8 secretion were remained whereas its effect on IL-6 and TNFalpha output did not occur in the cells with EP3 knockdown.	17-phenyltrinorprostaglandin E2	15-36	interleukin 1 beta	Homo sapiens	40-48
31008484-8	2019	The stimulatory effects of 17-phenyl-trinor-PGE2 on IL-6 and TNFalpha were remained whereas the inhibitory effects of 17-phenyl-trinor-PGE2 on IL-1beta secretion was blocked in the cells with EP1 knockdown.	17-phenyltrinorprostaglandin E2	118-139	interleukin 1 beta	Homo sapiens	143-151
31008484-11	2019	PI3K inhibitor LY294002 and P38 inhibitor SB202190 blocked 17-phenyl-trinor-PGE2-induced IL-1beta and IL-6 output, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 1 beta	Homo sapiens	89-97
31008484-11	2019	PI3K inhibitor LY294002 and P38 inhibitor SB202190 blocked 17-phenyl-trinor-PGE2-induced IL-1beta and IL-6 output, respectively.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	42-50	interleukin 1 beta	Homo sapiens	89-97
31008484-11	2019	PI3K inhibitor LY294002 and P38 inhibitor SB202190 blocked 17-phenyl-trinor-PGE2-induced IL-1beta and IL-6 output, respectively.	17-phenyltrinorprostaglandin E2	59-80	interleukin 1 beta	Homo sapiens	89-97
30938722-4	2019	In this study, we investigated the anti-inflammatory and chondroprotective effects of NOB on IL-1beta-induced human OA chondrocytes and in the surgical DMM mice OA models.	nobiletin	86-89	interleukin 1 beta	Homo sapiens	93-101
30938722-5	2019	In vitro, NOB treatment completely suppressed the overproduction of pro-inflammatory mediators, including PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 in IL-1beta-induced human OA chondrocytes.	nobiletin	10-13	interleukin 1 beta	Homo sapiens	151-159
30938722-7	2019	Furthermore, NOB dramatically suppressed the IL-1beta-stimulated phosphorylation of PI3K/Akt and activation of NF-kappaB in human OA chondrocytes.	nobiletin	13-16	interleukin 1 beta	Homo sapiens	45-53
30822454-5	2019	Expression analysis showed a significant effect of tibolone on genes associated with inflammation such as IL6, IL1B and miR155-3p.	tibolone	51-59	interleukin 1 beta	Homo sapiens	111-115
30999647-6	2019	The results showed that DHL inhibited LPS-induced production of proinflammatory mediators such as iNOS, NO, and cytokines including TNF-alpha, IL-6, IL-1beta, and IL-12 p35 by suppressing the activity of NF-kappaB via p38 MAPK/MK2 and Akt signaling pathway in macrophages.	dehydrocostus lactone	24-27	interleukin 1 beta	Homo sapiens	149-157
31139381-8	2019	In C6 cells, treatment with 27-OHC resulted in decreased secretion of IL-1beta, IL-10, TNF-alpha, and iNOS, and increased expression of TLR4 and TGF-beta.	27-hydroxycholesterol	28-34	interleukin 1 beta	Homo sapiens	70-78
30890405-11	2019	Pre-treatment with euxanthone markedly suppressed ox-LDL-induced ROS generation and inhibition of antioxidant enzymes, as well as the up-regulation of pro-inflammatory factors like MCP-1, IL-1beta and TNF-alpha in the HUVECs.	euxanthone	19-29	interleukin 1 beta	Homo sapiens	188-196
31093512-0	2019	Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1beta and TNF-alpha.	Calcitriol	0-10	interleukin 1 beta	Homo sapiens	137-145
31093512-3	2019	It is known that calcitriol, the active vitamin D metabolite, modulates the synthesis of immunological mediators; however, its role in the regulation of IL-1beta and TNF-alpha in TNBC has been scarcely studied.	Calcitriol	17-27	interleukin 1 beta	Homo sapiens	153-161
31093512-6	2019	In addition, we showed that synthesis of both IL-1beta and TNF-alpha was stimulated by calcitriol and its analogue.	Calcitriol	87-97	interleukin 1 beta	Homo sapiens	46-54
31093512-7	2019	Interestingly, the antiproliferative activity of calcitriol was significantly abrogated when the cells were treated with anti-IL-1beta receptor 1 (IL-1R1) and anti-TNF-alpha receptor type 1 (TNFR1) antibodies.	Calcitriol	49-59	interleukin 1 beta	Homo sapiens	126-134
31093512-9	2019	In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.	Calcitriol	41-51	interleukin 1 beta	Homo sapiens	127-135
31093512-9	2019	In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1beta and TNF-alpha through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.	Calcitriol	270-280	interleukin 1 beta	Homo sapiens	127-135
30963625-9	2019	Lidocaine dramatically reduced the protein expression of IL-1alpha, IL-6, THF-alpha, ELAVL1, NLRP3, caspase-1, and IL-1beta in adenovirus-infected thyroid follicular epithelial cells.	Lidocaine	0-9	interleukin 1 beta	Homo sapiens	115-123
31093510-10	2019	However, the rs16944 GG and rs1143627 AA genotypes of IL-1B may significantly impact the risk of CAL formation in children younger than 12 months, which may contribute to the pathogenesis of KD.	cal	97-100	interleukin 1 beta	Homo sapiens	54-59
30789669-9	2019	Additionally, LH supplementation significantly downregulated the mRNA expression of nuclear factor (NF)-kappaB, cyclooxygenase-2 (COX-2), and proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) and upregulated the mRNA expression of zonula occludens-1 (ZO-1) and Occludin in the jejunal mucosa induced by LPS (P &lt; 0.05).	Luteinizing Hormone	14-16	interleukin 1 beta	Homo sapiens	180-188
30958862-6	2019	Stimulation with LPS resulted in IL-1beta release; however, addition of ATP is necessary for "full-blown" inflammasome stimulation resulting in high IL-1beta and IL-18 release.	Adenosine Triphosphate	72-75	interleukin 1 beta	Homo sapiens	149-157
31019507-0	2019	SLPI Inhibits ATP-Mediated Maturation of IL-1beta in Human Monocytic Leukocytes: A Novel Function of an Old Player.	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	41-49
31019507-5	2019	In the present study, we tested the potential involvement of SLPI in the control of ATP-induced, inflammasome-dependent IL-1beta maturation and release.	Adenosine Triphosphate	84-87	interleukin 1 beta	Homo sapiens	120-128
31019507-7	2019	In contrast, the ATP-independent IL-1beta release induced by the pore forming bacterial toxin nigericin is not impaired, and SLPI does not directly modulate the ion channel function of the human P2X7 receptor heterologously expressed in Xenopus laevis oocytes.	Nigericin	94-103	interleukin 1 beta	Homo sapiens	33-41
31019507-11	2019	In conclusion, we propose a novel anti-inflammatory mechanism induced by SLPI, which inhibits the ATP-dependent maturation and secretion of IL-1beta.	Adenosine Triphosphate	98-101	interleukin 1 beta	Homo sapiens	140-148
30847537-0	2019	Carbon nanotubes and crystalline silica stimulate robust ROS production, inflammasome activation, and IL-1beta secretion in macrophages to induce myofibroblast transformation.	Carbon	0-6	interleukin 1 beta	Homo sapiens	102-110
30782482-9	2019	Analysis of the SMC supernatants by ELISA revealed CD-induced release of the senescence-associated cytokines IL-6 and MCP-1 in native and IFN-gamma-primed SMC, whereas no secretion of Interleukin-(IL) 1alpha and IL-1beta secretion were observed.	Cadmium	51-53	interleukin 1 beta	Homo sapiens	212-220
30983887-2	2019	Moreover, recent studies showed that accumulation of free cholesterol in macrophages leading to activation of NLRP3 inflammasome and production of interleukin-1beta (IL-1beta) has been linked to atherosclerosis-associated inflammation.	Cholesterol	58-69	interleukin 1 beta	Homo sapiens	147-164
30983887-2	2019	Moreover, recent studies showed that accumulation of free cholesterol in macrophages leading to activation of NLRP3 inflammasome and production of interleukin-1beta (IL-1beta) has been linked to atherosclerosis-associated inflammation.	Cholesterol	58-69	interleukin 1 beta	Homo sapiens	166-174
30773464-0	2019	Serine Metabolism Supports Macrophage IL-1beta Production.	Serine	0-6	interleukin 1 beta	Homo sapiens	38-46
30773464-4	2019	We find that in macrophages, serine is required for optimal lipopolysaccharide (LPS) induction of IL-1beta mRNA expression, but not inflammasome activation.	Serine	29-35	interleukin 1 beta	Homo sapiens	98-106
30773464-6	2019	Cell-permeable GSH, but not the one-carbon donor formate, rescues IL-1beta mRNA expression.	Glutathione	15-18	interleukin 1 beta	Homo sapiens	66-74
30773464-8	2019	Our study reveals that serine metabolism is necessary for GSH synthesis to support IL-1beta cytokine production.	Serine	23-29	interleukin 1 beta	Homo sapiens	83-91
30773464-8	2019	Our study reveals that serine metabolism is necessary for GSH synthesis to support IL-1beta cytokine production.	Glutathione	58-61	interleukin 1 beta	Homo sapiens	83-91
30782482-6	2019	Real-time RT-PCR revealed that CD significantly increased NLRP3 and IL1B mRNA expression in different SMC cultures within 6 h of exposure.	Cadmium	31-33	interleukin 1 beta	Homo sapiens	68-72
30847537-0	2019	Carbon nanotubes and crystalline silica stimulate robust ROS production, inflammasome activation, and IL-1beta secretion in macrophages to induce myofibroblast transformation.	Silicon Dioxide	33-39	interleukin 1 beta	Homo sapiens	102-110
30847537-9	2019	Induction of IL-1beta is dependent on the activation of the NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome and ROS (reactive oxygen species) production in macrophages, as inhibition of NLRP3 by MCC950 and reduction of ROS production by N-acetylcysteine blocked NLRP3 activation, IL-1beta induction, and fibroblast activation and differentiation.	Reactive Oxygen Species	137-140	interleukin 1 beta	Homo sapiens	13-21
30847537-9	2019	Induction of IL-1beta is dependent on the activation of the NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome and ROS (reactive oxygen species) production in macrophages, as inhibition of NLRP3 by MCC950 and reduction of ROS production by N-acetylcysteine blocked NLRP3 activation, IL-1beta induction, and fibroblast activation and differentiation.	Reactive Oxygen Species	142-165	interleukin 1 beta	Homo sapiens	13-21
30847537-9	2019	Induction of IL-1beta is dependent on the activation of the NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome and ROS (reactive oxygen species) production in macrophages, as inhibition of NLRP3 by MCC950 and reduction of ROS production by N-acetylcysteine blocked NLRP3 activation, IL-1beta induction, and fibroblast activation and differentiation.	Reactive Oxygen Species	244-247	interleukin 1 beta	Homo sapiens	13-21
30847537-9	2019	Induction of IL-1beta is dependent on the activation of the NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome and ROS (reactive oxygen species) production in macrophages, as inhibition of NLRP3 by MCC950 and reduction of ROS production by N-acetylcysteine blocked NLRP3 activation, IL-1beta induction, and fibroblast activation and differentiation.	Acetylcysteine	262-278	interleukin 1 beta	Homo sapiens	13-21
30847537-10	2019	Therefore, fibrogenic CNTs and silica, but not CB, elicit robust macrophage-guided myofibroblast transformation, which depends on the induction of IL-1beta through the NLRP3 inflammasome pathway and the increased production of ROS in macrophages.	Silicon Dioxide	31-37	interleukin 1 beta	Homo sapiens	147-155
30613914-6	2019	Pretreatment with specific inhibitors of ERK1/2 (U0126), JNK (SP600125), and AP-1 (tanshinone IIA) attenuated IL-1beta-induced MMP-9 expression.	U 0126	49-54	interleukin 1 beta	Homo sapiens	110-118
30797145-0	2019	Anthocyanins and metabolites from purple rice inhibit IL-1beta-induced matrix metalloproteinases expression in human articular chondrocytes through the NF-kappaB and ERK/MAPK pathway.	Anthocyanins	0-12	interleukin 1 beta	Homo sapiens	54-62
30797145-6	2019	Moreover, protocatechuic acid (PA), the main metabolite of anthocyanin, has chondroprotective potential by reducing glycosaminoglycans and collagen breakdown in IL-1beta/OSM-induced porcine cartilage explants in long-term condition.	protocatechuic acid	10-29	interleukin 1 beta	Homo sapiens	161-169
30797145-6	2019	Moreover, protocatechuic acid (PA), the main metabolite of anthocyanin, has chondroprotective potential by reducing glycosaminoglycans and collagen breakdown in IL-1beta/OSM-induced porcine cartilage explants in long-term condition.	protocatechuic acid	31-33	interleukin 1 beta	Homo sapiens	161-169
30797145-6	2019	Moreover, protocatechuic acid (PA), the main metabolite of anthocyanin, has chondroprotective potential by reducing glycosaminoglycans and collagen breakdown in IL-1beta/OSM-induced porcine cartilage explants in long-term condition.	Anthocyanins	59-70	interleukin 1 beta	Homo sapiens	161-169
30797145-9	2019	Additionally, PA pretreatment enhanced the phosphorylation of JNK in IL-1beta-stimulated human chondrocytes.	protocatechuic acid	14-16	interleukin 1 beta	Homo sapiens	69-77
30797145-10	2019	These findings indicated that anthocyanin in Thai purple rice exhibited anti-inflammatory effects in IL-1beta-stimulated human chondrocytes by inhibiting NF-kappaB and ERK/MAPK signaling pathway.	Anthocyanins	30-41	interleukin 1 beta	Homo sapiens	101-109
30935522-6	2019	DISCUSSION: GTP play a role in reducing TNF-alpha, Interleukin 1beta (IL-1beta), IL-6, IL-8, and 17; downregulate cyclooxygenase-mediated I kappa B kinase and transcription of NFkappaB.	Guanosine Triphosphate	12-15	interleukin 1 beta	Homo sapiens	51-68
30935522-6	2019	DISCUSSION: GTP play a role in reducing TNF-alpha, Interleukin 1beta (IL-1beta), IL-6, IL-8, and 17; downregulate cyclooxygenase-mediated I kappa B kinase and transcription of NFkappaB.	Guanosine Triphosphate	12-15	interleukin 1 beta	Homo sapiens	70-78
30747999-9	2019	Real-time quantitative polymerase chain reaction results indicated a trend toward lower expression of inflammatory markers IL-1beta and IL-6 and transforming growth factor beta after 3 weeks of treatment with rapamycin and curcumin compared to vehicle.	Sirolimus	209-218	interleukin 1 beta	Homo sapiens	123-131
30747999-9	2019	Real-time quantitative polymerase chain reaction results indicated a trend toward lower expression of inflammatory markers IL-1beta and IL-6 and transforming growth factor beta after 3 weeks of treatment with rapamycin and curcumin compared to vehicle.	Curcumin	223-231	interleukin 1 beta	Homo sapiens	123-131
31056982-5	2019	Additionally, osthole treatment reduced the expression of microglia and glial scar, lowered the level of the proinflammatory cytokines interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha), and blocked the activation of nuclear factor kappa B (NF-kappaB).	osthol	14-21	interleukin 1 beta	Homo sapiens	155-163
30660785-7	2019	RESULTS: Bacterial biomass, neutrophil percentage, IL-8, and IL-1beta levels were significantly higher in children with PBB compared with control patients.	pbb	120-123	interleukin 1 beta	Homo sapiens	61-69
30609183-5	2019	BPA promoted the generation of proinflammatory cytokines IL-1beta, IL-6, and TNFalpha in a concentration-dependent manner (P &lt; 0.05).	bisphenol A	0-3	interleukin 1 beta	Homo sapiens	57-65
30906473-9	2019	Conversely, exenatide led to an increase in IL-1beta in normoglycemic culture conditions, which was accompanied by the increased expression of p22, glutathione peroxidase and the reduced expression of GFAP.	Exenatide	12-21	interleukin 1 beta	Homo sapiens	44-52
30685700-4	2019	Moreover, IL-1beta-induced Sema4A upregulation is abrogated in the presence of BAY 11-7082, a specific inhibitor of NF-kappaB pathway, suggesting that the activation of NF-kappaB is required for Sema4A upregulation under this pathological condition.	3-(4-methylphenylsulfonyl)-2-propenenitrile	79-90	interleukin 1 beta	Homo sapiens	10-18
30613914-6	2019	Pretreatment with specific inhibitors of ERK1/2 (U0126), JNK (SP600125), and AP-1 (tanshinone IIA) attenuated IL-1beta-induced MMP-9 expression.	pyrazolanthrone	62-70	interleukin 1 beta	Homo sapiens	110-118
30613914-7	2019	In addition, inhibitors of ERK1/2 (U0126) and JNK (SP600125) attenuated IL-1beta-enhanced AP-1 activity.	U 0126	35-40	interleukin 1 beta	Homo sapiens	72-80
30613914-7	2019	In addition, inhibitors of ERK1/2 (U0126) and JNK (SP600125) attenuated IL-1beta-enhanced AP-1 activity.	pyrazolanthrone	51-59	interleukin 1 beta	Homo sapiens	72-80
30776647-5	2019	Western blot analysis demonstrated IL-1beta-induced NF-kappaB activation was reduced by oridonin.	oridonin	88-96	interleukin 1 beta	Homo sapiens	35-43
30776647-0	2019	Oridonin inhibits IL-1beta-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-gamma.	oridonin	0-8	interleukin 1 beta	Homo sapiens	18-26
30735689-3	2019	Undifferentiated THP1 cells constitutively express NLRP3, and NLRP3 inflammasome activation occurred in response to canonical NLRP3 activation stimuli including nigericin, ATP, and urea crystals, culminating in pro-IL-1beta cleavage, extracellular release of mature IL-1beta, and pyroptosis.	Adenosine Triphosphate	172-175	interleukin 1 beta	Homo sapiens	215-223
30776647-2	2019	In the present study, we investigated the effects of oridonin, a diterpenoid isolated from Rabdosia rubescens, on IL-1beta-induced inflammation using human osteoarthritis chondrocytes.	oridonin	53-61	interleukin 1 beta	Homo sapiens	114-122
30776647-3	2019	The results showed that oridonin significantly suppressed IL-1beta-induced MMP1, MMP3, and MMP13 production.	oridonin	24-32	interleukin 1 beta	Homo sapiens	58-66
30776647-4	2019	IL-1beta-induced NO and PGE2 production, as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression were also attenuated by oridonin.	Dinoprostone	24-28	interleukin 1 beta	Homo sapiens	0-8
30776647-4	2019	IL-1beta-induced NO and PGE2 production, as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression were also attenuated by oridonin.	oridonin	155-163	interleukin 1 beta	Homo sapiens	0-8
30816449-0	2019	Berberine prevents human nucleus pulposus cells from IL-1beta-induced extracellular matrix degradation and apoptosis by inhibiting the NF-kappaB pathway.	Berberine	0-9	interleukin 1 beta	Homo sapiens	53-61
30191990-5	2019	LA, DHA, 12(S)-HETE, and RvD1 elicited mRNA expression of proinflammatory markers; tumor necrosis factor-alpha ( Tnf-alpha), interleukin 6 ( IL-6), chemokine (C-C motif) ligand 2  (Ccl2), and IL-1beta in wild type (WT) and in 12/15LOX -/- macrophages at early time point (4 hr).	Docosahexaenoic Acids	4-7	interleukin 1 beta	Homo sapiens	192-200
30962733-8	2019	Ginsenosides have also been shown to inhibit caspase-1 and to decrease the expression of IL-1beta and IL-18.	Ginsenosides	0-12	interleukin 1 beta	Homo sapiens	89-97
30246378-9	2019	In vitro, arecoline increased ROS along with upregulation of the angiotensin-converting enzyme (ACE)/Ang-II/AT1R axis and NLRP3 inflammasome/interleukin-1beta axis in human oral myofibroblasts, which were reduced by NOX4 inhibitor VAS2870, ROS scavenger N-acetylcysteine, and NOX4 small interfering RNA (siRNA).	Arecoline	10-19	interleukin 1 beta	Homo sapiens	141-158
30735689-3	2019	Undifferentiated THP1 cells constitutively express NLRP3, and NLRP3 inflammasome activation occurred in response to canonical NLRP3 activation stimuli including nigericin, ATP, and urea crystals, culminating in pro-IL-1beta cleavage, extracellular release of mature IL-1beta, and pyroptosis.	Urea	181-185	interleukin 1 beta	Homo sapiens	215-223
30735689-3	2019	Undifferentiated THP1 cells constitutively express NLRP3, and NLRP3 inflammasome activation occurred in response to canonical NLRP3 activation stimuli including nigericin, ATP, and urea crystals, culminating in pro-IL-1beta cleavage, extracellular release of mature IL-1beta, and pyroptosis.	Urea	181-185	interleukin 1 beta	Homo sapiens	266-274
30502207-2	2019	By this means, flavonoids displayed significant antioxidant activity by donating electron, H atom as well as capturing DPPH and ABTS+ free radicals, and anti-inflammatory effect by inhibiting the production of the inflammatory mediators (NO radicals, PGE2 and TNF-alpha) and pro-inflammatory cytokines (IL-1beta and IL-6).	Flavonoids	15-25	interleukin 1 beta	Homo sapiens	303-311
30295316-16	2019	Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	74-82
30295316-16	2019	Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	86-94
30738820-7	2019	In a subset (n = 744) investigation of nutrient consumption related to salivary biomarkers, we found that elevated calorie-adjusted phosphorus intake was directly associated with salivary IL-1beta concentration (OR1.40, 95% CI 1.04-1.89), and inversely associated with salivary IL-4 concentration (OR0.62, 95% CI 0.46-0.84).	Phosphorus	132-142	interleukin 1 beta	Homo sapiens	188-196
30648758-0	2019	Melatonin attenuates TNF-alpha and IL-1beta expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	35-43
30648758-4	2019	We found that melatonin dose-dependently inhibits tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta expression through the PI3K/AKT, ERK, and NF-kappaB signaling pathways.	Melatonin	14-23	interleukin 1 beta	Homo sapiens	94-116
30648758-5	2019	We also identified that melatonin inhibits TNF-alpha and IL-1beta production by upregulating miR-3150a-3p expression.	Melatonin	24-33	interleukin 1 beta	Homo sapiens	57-65
30648758-8	2019	Our results indicate that melatonin ameliorates RA by inhibiting TNF-alpha and IL-1beta production through downregulation of the PI3K/AKT, ERK, NF-kappaB signaling pathways, as well as miR-3150a-3p overexpression.	Melatonin	26-35	interleukin 1 beta	Homo sapiens	79-87
31094457-5	2019	RESULTS: A decrease in the frequency of ARVI in patients with CHF treated with Amixin was found, which was accompanied by a decrease in the severity of subclinical inflammation by reducing the production of proinflammatory (IL-1beta) and increasing the production of anti-inflammatory (IL-10) cytokines, reducing neurohumoral activation (reducing levels of aldosterone and Nt-proBNP), increasing the level of alpha- and gamma-interferon.	Tilorone	79-85	interleukin 1 beta	Homo sapiens	224-232
31049124-0	2019	2-Allylphenol Reduces IL-1beta and TNF-alpha, Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms.	2-allylphenol	0-13	interleukin 1 beta	Homo sapiens	22-30
31049124-10	2019	In the peritonitis tests, 2-AP inhibited leukocyte migration and reduced releases of proinflammatory mediators TNF-alpha and IL-1beta.	2-allylphenol	26-30	interleukin 1 beta	Homo sapiens	125-133
31049139-11	2019	Cordycepin reduced the levels of TLR4, NF-kappaB, COX2, TNF-alpha, and IL-1beta in HEK293T cells too (P &lt; 0.05).	cordycepin	0-10	interleukin 1 beta	Homo sapiens	71-79
30925757-6	2019	Both curcumin and resveratrol down-regulated the level of Toll-like-receptor 4 mRNA and protein expression in the intestine to inhibit the release of critical inflammation molecules (interleukin-1beta, tumor necrosis factor-alpha), and increase the secretion of immunoglobulin.	Curcumin	5-13	interleukin 1 beta	Homo sapiens	183-229
30844228-8	2019	The intra-articular injection of MCD in combination with NIR radiation ensured a significant increase in the therapeutic effect of Dex at low systemic doses, which attenuated the cartilage erosion in the OA caused by the secretion of inflammatory factors including TNF-alpha and IL-1beta.	Dexamethasone	131-134	interleukin 1 beta	Homo sapiens	279-287
30925757-6	2019	Both curcumin and resveratrol down-regulated the level of Toll-like-receptor 4 mRNA and protein expression in the intestine to inhibit the release of critical inflammation molecules (interleukin-1beta, tumor necrosis factor-alpha), and increase the secretion of immunoglobulin.	Resveratrol	18-29	interleukin 1 beta	Homo sapiens	183-229
31007601-8	2019	During M1 polarization, propofol suppressed the production of IL-6 and IL-1beta but did not affect TNF-alpha production.	Propofol	24-32	interleukin 1 beta	Homo sapiens	71-79
30984167-14	2019	In contrast, only peficitinib and filgotinib decreased the IL-6 release of RASF activated with IL-1beta.	peficitinib	18-29	interleukin 1 beta	Homo sapiens	95-103
30984167-14	2019	In contrast, only peficitinib and filgotinib decreased the IL-6 release of RASF activated with IL-1beta.	GLPG0634	34-44	interleukin 1 beta	Homo sapiens	95-103
30984167-19	2019	Only peficitinib modulated the IL-1beta-induced response of RASF and their proliferation in vitro at concentrations close to reported Cmax values of well tolerated doses in vivo.	peficitinib	5-16	interleukin 1 beta	Homo sapiens	31-39
30695637-4	2019	Fluorescent-tagging using click-chemistry showed that IL-1beta reduces the level of newly synthesized proteins in proximal dendrites of cLTP stimulated neurons.	cltp	136-140	interleukin 1 beta	Homo sapiens	54-62
30695637-5	2019	Relative to controls, in cLTP stimulated neurons, IL-1beta inhibited Akt/mTOR signaling, as well as the upregulation of GluA1, an AMPA receptor subunit, and LIMK1, a kinase that promotes actin polymerization.	cltp	25-29	interleukin 1 beta	Homo sapiens	50-58
30936860-9	2019	Treatment of differentiated Caco-2 cells monolayer with BGZLS10-17 supernatant containing GABA alleviated inflammation (production of IL-8) caused by IL-1beta and significantly stimulated the expression of tight junction proteins (zonulin, occludin, and claudin 4), as well as the expression of TGF-beta cytokine leading to the conclusion that immunosuppression and strengthening the tight junctions can have significant role in the maintenance of intestinal epithelial barrier integrity.	gamma-Aminobutyric Acid	90-94	interleukin 1 beta	Homo sapiens	150-158
30852631-0	2019	Genetic polymorphisms in IL1B predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese Han population.	Steroids	56-63	interleukin 1 beta	Homo sapiens	25-29
30852631-1	2019	The purpose of this research was to examine if the IL1B gene polymorphism has impact on the risk of steroid-induced ONFH in Chinese population.	Steroids	100-107	interleukin 1 beta	Homo sapiens	51-55
30852631-2	2019	We found that IL1B rs1143630 decreased the SANFH"s risk and IL1B rs2853550 increased the risk of steroid-induced ONFH.	Steroids	97-104	interleukin 1 beta	Homo sapiens	60-64
30852631-3	2019	So, we guess that IL1B gene influences the genetic susceptibility of steroid-induced ONFH.	Steroids	69-76	interleukin 1 beta	Homo sapiens	18-22
30852631-5	2019	Discusses on the relationship between the IL1B gene and steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is still less in Chinese Han population.	Steroids	56-63	interleukin 1 beta	Homo sapiens	42-46
30852631-5	2019	Discusses on the relationship between the IL1B gene and steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is still less in Chinese Han population.	Steroids	107-114	interleukin 1 beta	Homo sapiens	42-46
30852631-6	2019	So, in this research, we want to examine whether the IL1B gene polymorphism has impact on the risk of steroid-induced ONFH in Chinese population.	Steroids	102-109	interleukin 1 beta	Homo sapiens	53-57
30852631-9	2019	RESULTS: rs1143630 (A&gt;C) in the IL1B gene decreased the risk of steroid-induced ONFH in the allele model (OR = 0.69, 95%CI 0.51-0.93, p = 0.014).	Steroids	67-74	interleukin 1 beta	Homo sapiens	35-39
30852631-10	2019	Further genetic model analyses found that IL1B rs2853550 AG genotype increased the risk of steroid-induced ONFH compared with the people who are carriers of the IL1B rs2853550 GG genotype (OR = 1.69, 95%CI 1.16-2.46, p = 0.012).	Steroids	91-98	interleukin 1 beta	Homo sapiens	42-46
30852631-11	2019	In the dominant model, IL1B rs1143630 GG-GT genotype decreased the risk of steroid-induced ONFH (OR = 0.62, 95%CI 0.44-0.87, p = 0.0051).	Steroids	75-82	interleukin 1 beta	Homo sapiens	23-27
30852631-14	2019	CONCLUSIONS: We guess that IL1B gene influences the genetic susceptibility of steroid-induced ONFH.	Steroids	78-85	interleukin 1 beta	Homo sapiens	27-31
30988608-9	2019	In vivo IONP-PEG induced an increment in complement activation markers (C5a and C5b-9), and proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha).	ionp-peg	8-16	interleukin 1 beta	Homo sapiens	119-127
30889841-6	2019	RPM exposure also induced a significantly altered release of the cytokines and bone biomarkers sclerostin (SOST), osteocalcin (OC), osteoprotegerin (OPG), osteopontin (OPN), interleukin 1 beta (IL-1beta) and tumour necrosis factor 1 alpha (TNF-1alpha).	Sirolimus	0-3	interleukin 1 beta	Homo sapiens	174-192
30889841-6	2019	RPM exposure also induced a significantly altered release of the cytokines and bone biomarkers sclerostin (SOST), osteocalcin (OC), osteoprotegerin (OPG), osteopontin (OPN), interleukin 1 beta (IL-1beta) and tumour necrosis factor 1 alpha (TNF-1alpha).	Sirolimus	0-3	interleukin 1 beta	Homo sapiens	194-202
30674535-0	2019	An ARC-Regulated IL1beta/Cox-2/PGE2/beta-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.	Dinoprostone	31-35	interleukin 1 beta	Homo sapiens	17-24
31007601-10	2019	Propofol was similar to the GABAA agonist muscimol in inducing nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) and inhibiting IL-6 and IL-1beta, but not TNF-alpha, production.	Propofol	0-8	interleukin 1 beta	Homo sapiens	154-162
30674535-3	2019	Malignant cells have been reported to release IL1beta, which induces PGE2 synthesis in mesenchymal stromal cells (MSC), in turn activating beta-catenin signaling and inducing the cancer stem cell phenotype.	Dinoprostone	69-73	interleukin 1 beta	Homo sapiens	46-53
30674535-5	2019	Here, we report that AML-MSC cocultures greatly increase Cox-2 expression in MSC and PGE2 production in an ARC/IL1beta-dependent manner.	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	111-118
31007601-11	2019	Knockdown of Nrf2 using siRNA significantly reduced the effect of propofol on IL-6 and IL-1beta production.	Propofol	66-74	interleukin 1 beta	Homo sapiens	87-95
31007601-12	2019	These results suggest that propofol prevents inflammatory responses during polarization of human M1 macrophages by suppressing the expression of IL-6 and IL-1beta through the GABAA receptor and the Nrf2-mediated signal transduction pathway.	Propofol	27-35	interleukin 1 beta	Homo sapiens	154-162
30956980-4	2019	RT-qPCR data confirmed the accuracy of microarray data, and cytokines assay results indicated that 6 of the total 27 inflammatory cytokine secretions were significantly inhibited by myricetin pretreatment, including TNF-alpha, IFN-gamma, IL-1alpha, IL-1beta, IL-2, and IL-6.	myricetin	182-191	interleukin 1 beta	Homo sapiens	249-257
30862856-9	2019	Plasma TMAO levels were negatively correlated with circulating EPC numbers and the FMD, and positively correlated with hsCRP, IL-1beta concentrations.	trimethyloxamine	7-11	interleukin 1 beta	Homo sapiens	126-134
30880909-9	2019	Conclusion: Administration of seawater is more effective than treatment with carmellose artificial tears in reducing symptoms and pro-inflammatory molecules (IL-1 beta and IL-6) in tears of patients with DES.	Carboxymethylcellulose Sodium	77-87	interleukin 1 beta	Homo sapiens	158-167
30861996-0	2019	Role of Norepinephrine in IL-1beta-Induced Chondrocyte Dedifferentiation under Physioxia.	Norepinephrine	8-22	interleukin 1 beta	Homo sapiens	26-34
30861996-7	2019	Moderate glycosaminoglycan (GAG) staining was observed in untreated and NE-treated cells, while IL-1beta strongly decreased GAG deposition.	Glycosaminoglycans	124-127	interleukin 1 beta	Homo sapiens	96-104
30866565-5	2019	Several fatty acids were associated with interferon-gamma (IFNgamma) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year.	Fatty Acids	8-19	interleukin 1 beta	Homo sapiens	153-158
30866458-9	2019	In particular, menadione inhibited nuclear factor kappa-light-chain-enhancer of activated B cell (NF-kappaB) activation and thereby reduced expression of the proinflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha in AGS as well as in THP-1 (monocytic leukemia cell) cell lines.	Vitamin K 3	15-24	interleukin 1 beta	Homo sapiens	192-200
30641295-8	2019	RESULTS: Of all analyzed proteins, only the levels of IL-1alpha, Il-1beta and TNFalpha in GCF from the injured teeth with resorption were higher than in GCF from control teeth on the visit during which the EIRR was diagnosed.	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	90-93	interleukin 1 beta	Homo sapiens	65-73
30846730-9	2019	In addition to the angiogenesis-promoting action of PC, it also showed anti-inflammatory activity by reducing TNF-alpha-mediated IL-1beta and IL-6 expression.	pc	52-54	interleukin 1 beta	Homo sapiens	129-137
30600004-5	2019	Additionally, HMO-7 was found to stimulate the release of ROS, TNF-alpha and cytokines including IL-1beta, IL-2, IL-6 and IL-10 in RAW264.7 macrophages.	hmo-7	14-19	interleukin 1 beta	Homo sapiens	97-105
30594048-9	2019	PNU-282987, an alpha7nAChR agonist, significantly decreased TNF-alpha, IL-1beta, and IL-6 but increased IL-10 in the monocyte culture supernatant of active LN patients, which were abolished by an alpha7nAChR antagonist methyllycaconitine.	N-neopentyl-N-nitrosourea	0-3	interleukin 1 beta	Homo sapiens	71-79
30594784-6	2019	The addition of zafirlukast to culture media suppressed TNF-alpha-induced expression of endothelial vascular adhesion molecules, such as ICAM-1, VCAM-1, and induction of cytokines, including IL-1beta, IL-6, and IL-8.	zafirlukast	16-27	interleukin 1 beta	Homo sapiens	191-199
30539420-8	2019	The enhanced BCL2 and VEGF parallel with the reduced NFkappaB1, TNF-alpha, IL-1beta, and iNOS mRNA levels in miR-9 mimic or glucosamine-treated cells further substantiated their post-ischemic neuroprotective and regenerative efficacy.	Glucosamine	124-135	interleukin 1 beta	Homo sapiens	75-83
30557692-13	2019	CONCLUSIONS: Despite limitations, our results support associations between O&amp;G activity and augmentation index, SBP, DBP, IL-1beta, and TNF-alpha.	o&amp	75-80	interleukin 1 beta	Homo sapiens	126-134
30265130-10	2019	IL-10 and IL-1beta release for all TiO2NP were noted around the detection limit with no significant changes compared to control.	tio2np	35-41	interleukin 1 beta	Homo sapiens	10-18
30632646-2	2019	Several recent studies have demonstrated a significant decrease of serum urate during acute gout attack, which is an aseptic inflammation process focusing on IL-1beta.	Uric Acid	73-78	interleukin 1 beta	Homo sapiens	158-166
30773944-9	2019	Treatment with celastrol inhibited colorectal cancer cell growth and migration, and was associated with suppression of the expression of key genes (TYMP, CDH5, THBS2, LEP, MMP9, and TNF) and proteins (IL-1b, MMP-9, PDGF, Serpin E1, and TIMP-4) involved in the angiogenesis pathway.	celastrol	15-24	interleukin 1 beta	Homo sapiens	201-206
30578561-0	2019	Interleukin-1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel-associated acute pain syndrome.	Paclitaxel	119-129	interleukin 1 beta	Homo sapiens	0-17
29101106-3	2019	Notably, the IL-1 family cytokine IL-33 promotes adaptive and innate type 2 immune responses, confers viral protection and facilitates glucose metabolism and tissue repair.	Glucose	135-142	interleukin 1 beta	Homo sapiens	13-17
30458287-9	2019	MiR-202-3p suppressed IL-1beta-induced MMP-1 production.	mir-202-3p	0-10	interleukin 1 beta	Homo sapiens	22-30
30578561-7	2019	TLR4 activation in microglia by paclitaxel caused microglia to rapidly release interleukin-1beta (IL-1beta) but not tumor necrosis factor alpha, IL-6, or interferon-gamma.	Paclitaxel	32-42	interleukin 1 beta	Homo sapiens	79-96
30578561-7	2019	TLR4 activation in microglia by paclitaxel caused microglia to rapidly release interleukin-1beta (IL-1beta) but not tumor necrosis factor alpha, IL-6, or interferon-gamma.	Paclitaxel	32-42	interleukin 1 beta	Homo sapiens	98-106
30578561-9	2019	IL-1beta acted on astrocytes, leading to elevated calcium activity and suppressed glutamate uptake.	Calcium	50-57	interleukin 1 beta	Homo sapiens	0-8
30237268-7	2019	This study demonstrates that transglutaminase 2 expression induced by all-trans retinoic acid treatment reprograms inflammatory signaling networks governed by nuclear factor kappa-light-chain-enhancer of activated B-cell activation, resulting in overexpression of TNF-alpha and IL-1beta in differentiating APL cells, suggesting that atypically expressed transglutaminase 2 is a promising target for leukemia treatment.	Tretinoin	80-93	interleukin 1 beta	Homo sapiens	278-286
30578561-9	2019	IL-1beta acted on astrocytes, leading to elevated calcium activity and suppressed glutamate uptake.	Glutamic Acid	82-91	interleukin 1 beta	Homo sapiens	0-8
30578561-10	2019	IL-1beta also acted on neurons to increase presynaptic glutamate release and postsynaptic AMPA receptor activity in the spinal dorsal horn.	Glutamic Acid	55-64	interleukin 1 beta	Homo sapiens	0-8
30628668-5	2019	The overexpression of miRNA-20b increased the levels of IL-1beta and IL-18 in the cerebral ischemia group through activation of the NLRP3 signaling pathway.	mirna-20b	22-31	interleukin 1 beta	Homo sapiens	56-64
30664190-7	2019	It was observed that SUA significantly enhanced APN mRNA and protein expression (both P&lt;0.05) and increased NLRP3 (P&lt;0.001) and TNFalpha (P&lt;0.05) protein levels, as well as supernatant levels of IL-1beta (P&lt;0.01) and TNFalpha (P&lt;0.001) compared with untreated cells.	sua	21-24	interleukin 1 beta	Homo sapiens	204-212
30628668-6	2019	Conversely, the downregulation of miRNA-20b suppressed IL-1beta and IL-18 levels in cerebral ischemia via suppression of the NLRP3 signaling pathway.	mirna-20b	34-43	interleukin 1 beta	Homo sapiens	55-63
30604480-6	2019	Furthermore, activation of nuclear factor kappaB (NF-kappaB), which was induced by IL-1beta, was also inhibited by SA through the pathway of nuclear factor-erythroid 2-related factor-2 (Nrf2)/heme oxygenase 1.	sinapinic acid	115-117	interleukin 1 beta	Homo sapiens	83-91
30604480-4	2019	Compared with controls, SA-pretreated human chondrocytes showed lower levels of interleukin (IL)-1beta-induced IL-6, prostaglandin E2 (PGE2), nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) in vitro.	sinapinic acid	24-26	interleukin 1 beta	Homo sapiens	80-102
31933895-9	2019	Additionally, dioscin downregulated interleukin-6 (IL-6), IL-1beta and tumor necrosis factor alpha (TNF-alpha).	dioscin	14-21	interleukin 1 beta	Homo sapiens	58-66
30638709-6	2019	Treatment ex vivo with TPC decreased the production of IL-1beta, IL-2, IL-5, IL-6, IL-9, IL-12(p70), IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IFNgamma, TNFalpha, GM-CSF by CD3/CD28 activated PBMCs whereas it negligibly affected cell viability.	tpc	23-26	interleukin 1 beta	Homo sapiens	55-63
30638709-8	2019	In inflamed TABs, treatment with TPC down-regulated the production of IL-1beta, IL-6, IL-13, IL-17A and CD68 gene expression.	tpc	33-36	interleukin 1 beta	Homo sapiens	70-78
30637441-10	2019	KEY MESSAGE: Resveratrol has negative effects on pro-IL-1beta synthesis through Syk and p38.	Resveratrol	13-24	interleukin 1 beta	Homo sapiens	49-61
30700584-3	2019	Previous studies have demonstrated that the pan-hydroxylase inhibitor dimethyloxalylglycine (DMOG) is effective in the alleviation of inflammation in preclinical models of inflammatory bowel disease, at least in part, through suppression of IL-1beta-induced NF-kappaB activity.	oxalylglycine	70-91	interleukin 1 beta	Homo sapiens	241-249
30700584-3	2019	Previous studies have demonstrated that the pan-hydroxylase inhibitor dimethyloxalylglycine (DMOG) is effective in the alleviation of inflammation in preclinical models of inflammatory bowel disease, at least in part, through suppression of IL-1beta-induced NF-kappaB activity.	oxalylglycine	93-97	interleukin 1 beta	Homo sapiens	241-249
30660990-8	2019	Also, ELISA results demonstrate that anagliptin treatment significantly abolished high glucose- induced maturation of IL-1beta and IL-18.	anagliptin	37-47	interleukin 1 beta	Homo sapiens	118-126
30519866-7	2019	Our data show that dopamine treatment of human macrophages isolated from healthy and cART-treated donors promotes production of inflammatory mediators including IL-1beta, IL-6, IL-18, CCL2, CXCL8, CXCL9, and CXCL10.	Dopamine	19-27	interleukin 1 beta	Homo sapiens	161-169
30628671-5	2019	The results of the present study demonstrated that caspase-1 activity, interleukin (IL)-1beta and IL-18 were upregulated in patients with RSA compared with healthy controls.	rabbit sperm membrane autoantigen	138-141	interleukin 1 beta	Homo sapiens	71-93
30660990-8	2019	Also, ELISA results demonstrate that anagliptin treatment significantly abolished high glucose- induced maturation of IL-1beta and IL-18.	Glucose	87-94	interleukin 1 beta	Homo sapiens	118-126
30414920-0	2019	Hyphae fragments from A. fumigatus sensitize lung cells to silica particles (Min-U-Sil): Increased release of IL-1beta.	Silicon Dioxide	59-65	interleukin 1 beta	Homo sapiens	110-118
31106534-8	2019	CONCLUSION: IL-1beta pretreatment enhanced the secretion of PGE2 and VEGF, and induced macrophage M2 polarization, which depended on COX-2-PGE2 signal pathway.	Dinoprostone	60-64	interleukin 1 beta	Homo sapiens	12-20
31106534-8	2019	CONCLUSION: IL-1beta pretreatment enhanced the secretion of PGE2 and VEGF, and induced macrophage M2 polarization, which depended on COX-2-PGE2 signal pathway.	Dinoprostone	139-143	interleukin 1 beta	Homo sapiens	12-20
30496753-6	2019	Ketamine also abrogated LPS-induced over expression of IL-1beta and NLRP3 and reversed LPS-induced down-regulation of AMPA GluA1 subunits in hippocampi.	Ketamine	0-8	interleukin 1 beta	Homo sapiens	55-63
30547277-10	2019	Using an ATP model of stimulation, we further demonstrated that extracellular ATP stimulation to IL-1beta containing LPS microparticles induces release of its content, which when subjected to epithelial cells induced IL-8.	Adenosine Triphosphate	9-12	interleukin 1 beta	Homo sapiens	97-105
30547277-10	2019	Using an ATP model of stimulation, we further demonstrated that extracellular ATP stimulation to IL-1beta containing LPS microparticles induces release of its content, which when subjected to epithelial cells induced IL-8.	Adenosine Triphosphate	78-81	interleukin 1 beta	Homo sapiens	97-105
31106534-5	2019	RESULTS: IL-1beta pretreating ADMSCs increased the expression level of COX-2, enhanced PGE2 and VEGF secretions (P&lt;0.05).	Dinoprostone	87-91	interleukin 1 beta	Homo sapiens	9-17
30414920-6	2019	Notably, the AFH- and LPS-induced IL-1beta responses with and without co-exposure to Min-U-Sil in THP-1 Mo were found to be caspase-dependent as shown by inhibition with zYVAD-fmk.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	170-179	interleukin 1 beta	Homo sapiens	34-42
30821011-9	2019	Moreover, the activated RIP3 reversed the inhibition of RIP3 and MLKL expression and the levels of TNF-alpha, IL-1beta, and lactate dehydrogenase, which were induced by transfection with miR-223-3p in a H 2 O 2 -induced model.	mir-223-3p	187-197	interleukin 1 beta	Homo sapiens	110-118
30810625-10	2019	In addition, 5-FU injection caused pronounced tissue injury accompanied by increased neutrophil accumulation, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta) tissue levels, and positive immunostaining for TNF-alpha, IL-1beta, and inducible nitric oxide synthase (iNOS).	Fluorouracil	13-17	interleukin 1 beta	Homo sapiens	155-173
30813930-8	2019	RESULTS: As a critical regulator, vitamin D suppresses LPS-induced HIF-1alpha to block IFNgamma and IL-1beta productions.	Vitamin D	34-43	interleukin 1 beta	Homo sapiens	100-108
30804327-6	2019	NLRP3 inflammasome activation by the bacterial toxin nigericin led to the proinflammatory interleukin-1beta (IL-1beta) release and to the induction of cell death by pyroptosis.	Nigericin	53-62	interleukin 1 beta	Homo sapiens	90-107
30804327-6	2019	NLRP3 inflammasome activation by the bacterial toxin nigericin led to the proinflammatory interleukin-1beta (IL-1beta) release and to the induction of cell death by pyroptosis.	Nigericin	53-62	interleukin 1 beta	Homo sapiens	109-117
30810625-10	2019	In addition, 5-FU injection caused pronounced tissue injury accompanied by increased neutrophil accumulation, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta) tissue levels, and positive immunostaining for TNF-alpha, IL-1beta, and inducible nitric oxide synthase (iNOS).	Fluorouracil	13-17	interleukin 1 beta	Homo sapiens	175-183
30810625-10	2019	In addition, 5-FU injection caused pronounced tissue injury accompanied by increased neutrophil accumulation, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta) tissue levels, and positive immunostaining for TNF-alpha, IL-1beta, and inducible nitric oxide synthase (iNOS).	Fluorouracil	13-17	interleukin 1 beta	Homo sapiens	243-251
30906223-7	2019	The results showed that high glucose increased the expression of interleukin-18 (IL-18), interleukin-1beta (IL-1beta), NLRP3, caspase-1, and ASC, as well as the protein level of TLR4, nucleus p65, and CaSR.	Glucose	29-36	interleukin 1 beta	Homo sapiens	89-106
30842737-10	2019	GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels.	GYY 4137	0-7	interleukin 1 beta	Homo sapiens	151-159
30842737-10	2019	GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels.	4-anisyltetrazolium blue	12-15	interleukin 1 beta	Homo sapiens	151-159
30842807-4	2019	This resulted in an optimal injury of 20% (v/v) ethanol for 30 s with 1 ng/mL interleukin-1 (IL-1) beta.	Ethanol	48-55	interleukin 1 beta	Homo sapiens	93-103
30786900-8	2019	RESULTS: We confirmed that I-BET151 could suppress the IL-1beta- or TNF-alpha-induced expression of MMP1, MMP3, MMP13, and ADAMTS4 in SW1353 cells.	GSK1210151A	27-35	interleukin 1 beta	Homo sapiens	55-64
30906223-9	2019	Meanwhile, NPS2143, BAY 11-7082, and INF39 could significantly abolish the high glucose-enhanced NLRP3, ASC, caspase-1, IL-18, and IL-1beta expression in vitro.	Glucose	80-87	interleukin 1 beta	Homo sapiens	131-139
30906223-7	2019	The results showed that high glucose increased the expression of interleukin-18 (IL-18), interleukin-1beta (IL-1beta), NLRP3, caspase-1, and ASC, as well as the protein level of TLR4, nucleus p65, and CaSR.	Glucose	29-36	interleukin 1 beta	Homo sapiens	108-116
30906223-10	2019	In addition, both NPS2143 and BAY 11-7082 attenuated high glucose-induced upregulation of NLRP3, ASC, caspase-1, IL-18, and IL-1beta expression.	3-(4-methylphenylsulfonyl)-2-propenenitrile	30-41	interleukin 1 beta	Homo sapiens	124-132
30906223-10	2019	In addition, both NPS2143 and BAY 11-7082 attenuated high glucose-induced upregulation of NLRP3, ASC, caspase-1, IL-18, and IL-1beta expression.	Glucose	58-65	interleukin 1 beta	Homo sapiens	124-132
30760247-3	2019	Vitamin D induces IL-1beta, which plays an important role in terms of resistance to TB.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	18-26
30620895-5	2019	KEY FINDINGS: The protective effects of BCP on LPS-induced microglia imbalance is provided by the M2 healing phenotype of microglia, releasing the anti-inflammatory (IL-10, Arg-1, and urea) and anti-oxidant (GSH) parameters and reducing the inflammatory (IL-1beta, TNF-alpha, PGE2, iNOS and NO) and oxidative (ROS) biomarkers.	caryophyllene	40-43	interleukin 1 beta	Homo sapiens	255-263
30548778-11	2019	Pearson correlation analysis showed IL-1beta was positively correlated with CBL (P = .0079), whereas IL-6 showed positive correlation with both BOP (P = .0019) and CBL (P = .015) among obese patients.	Vitamin B 12	76-79	interleukin 1 beta	Homo sapiens	36-44
30308801-11	2019	Conversely, an interquartile range increase in ethyl paraben (10.4 ng/mL) was associated with a 7.7% decrease in interleukin-1beta (95% CI: -14.1, -0.86).	ethyl-p-hydroxybenzoate	47-60	interleukin 1 beta	Homo sapiens	113-130
30452909-2	2019	The results of our study reveal that vildagliptin reduced degradation of the articular extracellular matrix (ECM) by downregulating IL-1beta-induced expression of matrix metalloproteinases-3 (MMP-3), matrix metalloproteinases-13 (MMP-13), a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5).	Vildagliptin	37-49	interleukin 1 beta	Homo sapiens	132-140
30452909-3	2019	We also found that vildagliptin ameliorated IL-1beta-induced activation of the JNK/AP-1 and nuclear factor-kappaB (NF-kappaB) pro-inflammatory signaling pathways by downregulating phosphorylation of JNK and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (IkappaBalpha), activation of c-Fos/c-Jun, and nuclear translocation of p65.	Vildagliptin	19-31	interleukin 1 beta	Homo sapiens	44-52
30775257-7	2019	Post-HSCT patients with MPS II showed that IL-1beta and IL-6 were normalized as HS and DS levels decreased.	Dermatan Sulfate	87-89	interleukin 1 beta	Homo sapiens	43-51
30545920-0	2019	Macrophage-Derived IL1beta and TNFalpha Regulate Arginine Metabolism in Neuroblastoma.	Arginine	49-57	interleukin 1 beta	Homo sapiens	19-26
30815434-2	2019	IL-1beta signaling leads to parturition in preterm birth (PTB) and contributes to the retinal vaso-obliteration characteristic of oxygen-induced retinopathy (OIR) of premature infants.	Oxygen	130-136	interleukin 1 beta	Homo sapiens	0-8
30585659-7	2019	Using THP-1 cell in vitro model, we show that IL1beta and CASP-1 are regulated by dapsone independently of NFkappaB activity at transcriptional and post-transcriptional levels, respectively.	Dapsone	82-89	interleukin 1 beta	Homo sapiens	46-53
30825883-7	2019	EGCG treatment significantly suppressed the interleukin 1 beta (IL-1beta)-induced elevation of mRNA expression of pain mediators, proinflammatory cytokines, and matrix metalloproteinases (MMPs) in bursa cells in vitro; conditioned medium from EGCG-treated bursa cells significantly reduced IL-1beta-induced expression in human primary tenocytes.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	44-62
30825883-7	2019	EGCG treatment significantly suppressed the interleukin 1 beta (IL-1beta)-induced elevation of mRNA expression of pain mediators, proinflammatory cytokines, and matrix metalloproteinases (MMPs) in bursa cells in vitro; conditioned medium from EGCG-treated bursa cells significantly reduced IL-1beta-induced expression in human primary tenocytes.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	64-72
30825883-7	2019	EGCG treatment significantly suppressed the interleukin 1 beta (IL-1beta)-induced elevation of mRNA expression of pain mediators, proinflammatory cytokines, and matrix metalloproteinases (MMPs) in bursa cells in vitro; conditioned medium from EGCG-treated bursa cells significantly reduced IL-1beta-induced expression in human primary tenocytes.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	290-298
30825883-7	2019	EGCG treatment significantly suppressed the interleukin 1 beta (IL-1beta)-induced elevation of mRNA expression of pain mediators, proinflammatory cytokines, and matrix metalloproteinases (MMPs) in bursa cells in vitro; conditioned medium from EGCG-treated bursa cells significantly reduced IL-1beta-induced expression in human primary tenocytes.	epigallocatechin gallate	243-247	interleukin 1 beta	Homo sapiens	44-62
30825883-7	2019	EGCG treatment significantly suppressed the interleukin 1 beta (IL-1beta)-induced elevation of mRNA expression of pain mediators, proinflammatory cytokines, and matrix metalloproteinases (MMPs) in bursa cells in vitro; conditioned medium from EGCG-treated bursa cells significantly reduced IL-1beta-induced expression in human primary tenocytes.	epigallocatechin gallate	243-247	interleukin 1 beta	Homo sapiens	64-72
30025186-7	2019	Verapamil has been shown to inhibit TNF-alpha and IL-1beta in vitro and in vivo.	Verapamil	0-9	interleukin 1 beta	Homo sapiens	50-58
30025186-8	2019	We hypothesize that verapamil inhibits the inflammatory process through the TNF-alpha/IL-1 pathway involved in the HS physiopathology.	Verapamil	20-29	interleukin 1 beta	Homo sapiens	86-90
30025186-9	2019	Compared to biologic agents as anti-TNF-alpha (adalimumab) and anti-IL1 (anakinra), verapamil is safer and cheaper.	Verapamil	84-93	interleukin 1 beta	Homo sapiens	68-71
30025186-10	2019	Given its possible role on TNF-alpha/IL-1, verapamil may represent an alternative therapeutic option in mild and moderate HS.	Verapamil	43-52	interleukin 1 beta	Homo sapiens	37-41
30447168-5	2019	In experiments with monocyte-derived macrophages, we found that interleukin (IL)-1beta secretion was inhibited after 7 h of exposure (but not 48 h of exposure) to ethanol.	Ethanol	163-170	interleukin 1 beta	Homo sapiens	64-86
30242542-11	2019	Moreover, NF-kappaB inhibitor restored the elevation of TNF-alpha, IL-1beta, IL-6, and MMP-9 induced by miR-410-3p inhibition.	p-Bis(2-chloroethyl)amino-o-methoxyphenylalanine	112-114	interleukin 1 beta	Homo sapiens	67-75
30280295-7	2019	By contrast, reactivity of ATs to IL-1beta was significantly lower in OA than RA and IL-1beta antagonist (IL-1Ra) could be responsible for this because we found its overproduction in OA ATs.	Astatine	27-30	interleukin 1 beta	Homo sapiens	34-42
30600470-9	2019	Furthermore, high doses of resveratrol ameliorated the release of the inflammatory cytokine IL-1beta.	Resveratrol	27-38	interleukin 1 beta	Homo sapiens	92-100
30544066-3	2019	The purpose of this study was to investigate the effects of GA on IL-1beta-induced HIEC-6 cells and TNBS-induced UC in mice.	Gallic Acid	60-62	interleukin 1 beta	Homo sapiens	66-74
30544066-6	2019	Our results showed that administration of GA significantly increased the expressions of IL-4, and IL-10, while down-regulated IL-1, IL-6, IL-12, IL-17, IL-23, TGF-beta and TNF-alpha expressions compared with a model control group in vitro and in vivo.	Gallic Acid	42-44	interleukin 1 beta	Homo sapiens	98-102
30447168-6	2019	The disappearance of ethanol"s inhibitory effect on IL-1beta secretion after 48 h was not mediated by the upregulated production of IL-1beta, IL-1alpha, IL-6 or the inflammasome components NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain, and caspase 1.	Ethanol	21-28	interleukin 1 beta	Homo sapiens	52-60
30001171-9	2019	Serum concentrations of both IL 1-beta (R value: -0.624; P &lt; 0.001) and IL-6 (R value: -0.642; P &lt; 0.001) were inversely correlated to the serum concentrations of selenium.	Selenium	169-177	interleukin 1 beta	Homo sapiens	29-38
30600470-2	2019	Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1beta) release in vitro.	Resveratrol	28-39	interleukin 1 beta	Homo sapiens	69-87
30600470-2	2019	Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1beta) release in vitro.	Resveratrol	28-39	interleukin 1 beta	Homo sapiens	89-97
30553912-5	2019	In addition, we found that the mRNA expression of IL-1beta, IL-6, IL-8 and IL-17A were markedly down-regulated by treatment with betulinic acid in TNF-alpha-induced RA FLSs.	betulinic acid	129-143	interleukin 1 beta	Homo sapiens	50-58
30336275-9	2019	Furthermore, reduced S1P2 and increased S1P3 and S1P4 mRNA expression levels upon treatment with 1,25(OH)2D3 occurred in the presence of IL-1beta.	Calcitriol	97-108	interleukin 1 beta	Homo sapiens	137-145
30595336-8	2019	Besides, the production of TNF-alpha, IL-1beta, IL-6, fibronectin (FN) and collagen IV (Col IV) was also inhibited by daphnetin in HG-stimulated MCs.	daphnetin	118-127	interleukin 1 beta	Homo sapiens	38-46
30359690-9	2019	Accordingly, VD-metabolites (25-hydroxyvitamin D3, calcitriol) significantly stimulated IL-1beta gene expression in cultured trophoblasts.	Calcifediol	29-49	interleukin 1 beta	Homo sapiens	88-96
30359690-9	2019	Accordingly, VD-metabolites (25-hydroxyvitamin D3, calcitriol) significantly stimulated IL-1beta gene expression in cultured trophoblasts.	Calcitriol	51-61	interleukin 1 beta	Homo sapiens	88-96
30611121-0	2019	Calcitriol inhibits ROS-NLRP3-IL-1beta signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells.	Calcitriol	0-10	interleukin 1 beta	Homo sapiens	30-38
30030777-6	2019	Nicotine, 4-NQO, and their combinational applications with Pg LPS induced the secretions of IL-1beta and IL-1Ra, while that of IL-8 was inhibited by the presence of Pg LPS.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	92-100
30030777-6	2019	Nicotine, 4-NQO, and their combinational applications with Pg LPS induced the secretions of IL-1beta and IL-1Ra, while that of IL-8 was inhibited by the presence of Pg LPS.	4-Nitroquinoline-1-oxide	10-15	interleukin 1 beta	Homo sapiens	92-100
30661603-1	2019	IL-1beta stimulates expression of prostaglandin (PG)-synthesizing enzymes cyclooxygenase (COX)-2 and aldo-keto reductase (AKR)1B1 in human preadipocytes.	Prostaglandins	34-52	interleukin 1 beta	Homo sapiens	0-8
30696600-5	2019	Additionally, silicon may induce mononuclear cells to secrete proinflammatory cytokines IL-1beta, IL-6 and TNF-alpha.	Silicon	14-21	interleukin 1 beta	Homo sapiens	88-96
30569107-7	2019	The present data indicated that, compared with mannitol treatment, high glucose treatment reduced RPEC viability, increased TNF-alpha, IL-6 and IL-1beta secretion, increased ROS formation and promoted phosphorylation of AKT and mTOR.	Glucose	72-79	interleukin 1 beta	Homo sapiens	144-152
30668389-0	2019	The therapeutic effect of aucubin-supplemented hyaluronic acid on interleukin-1beta-stimulated human articular chondrocytes.	Hyaluronic Acid	47-62	interleukin 1 beta	Homo sapiens	66-83
30668389-6	2019	We then evaluated the therapeutic effects of HA (100 mug/ml) supplemented with aucubin (10 mug/ml) on interleukin-1 beta (IL-1beta, 10 ng/ml)-stimulated chondrocytes.	Hyaluronic Acid	45-47	interleukin 1 beta	Homo sapiens	102-120
30668389-6	2019	We then evaluated the therapeutic effects of HA (100 mug/ml) supplemented with aucubin (10 mug/ml) on interleukin-1 beta (IL-1beta, 10 ng/ml)-stimulated chondrocytes.	Hyaluronic Acid	45-47	interleukin 1 beta	Homo sapiens	122-130
30661603-7	2019	Adding Statil or NS-398 to IL-1beta blunted PGF2alpha and PGE2 release, but did not alter IL-1beta effects on adipose tissue function markers.	Dinoprost	44-53	interleukin 1 beta	Homo sapiens	27-35
30661603-7	2019	Adding Statil or NS-398 to IL-1beta blunted PGF2alpha and PGE2 release, but did not alter IL-1beta effects on adipose tissue function markers.	Dinoprostone	58-62	interleukin 1 beta	Homo sapiens	27-35
30611121-0	2019	Calcitriol inhibits ROS-NLRP3-IL-1beta signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells.	ros	20-23	interleukin 1 beta	Homo sapiens	30-38
30611121-1	2019	PURPOSE: The activation of ROS-NLRP3-IL-1beta signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis.	ros	27-30	interleukin 1 beta	Homo sapiens	37-45
30611121-8	2019	RESULTS: Calcitriol could protect cells against HS-induced injury through inhibiting ROS-NLRP3-IL-1beta signaling axis.	Calcitriol	9-19	interleukin 1 beta	Homo sapiens	95-103
30611121-8	2019	RESULTS: Calcitriol could protect cells against HS-induced injury through inhibiting ROS-NLRP3-IL-1beta signaling axis.	ros	85-88	interleukin 1 beta	Homo sapiens	95-103
30611121-9	2019	Calcitriol remarkably suppressed the expression of NLRP3 inflammasome related genes and the production of IL-1beta in cells that were exposed to HS.	Calcitriol	0-10	interleukin 1 beta	Homo sapiens	106-114
30761006-12	2019	CRP not only increased the expression of pro-IL-1beta and NLRP3 via the FcgammaRs/NF-kappaB pathway, but also promoted NLRP3 inflammasome activation and IL-1beta maturation by upregulation of reactive oxygen species (ROS) levels, purinergic receptor signaling, and activation of cysteine proteases.	Reactive Oxygen Species	192-215	interleukin 1 beta	Homo sapiens	41-53
30761006-12	2019	CRP not only increased the expression of pro-IL-1beta and NLRP3 via the FcgammaRs/NF-kappaB pathway, but also promoted NLRP3 inflammasome activation and IL-1beta maturation by upregulation of reactive oxygen species (ROS) levels, purinergic receptor signaling, and activation of cysteine proteases.	Reactive Oxygen Species	217-220	interleukin 1 beta	Homo sapiens	41-53
30618231-6	2019	NPcurcumin effectively reduced the number of activated M1 microglia and weakened the increase in TNF-alpha and IL-1beta.	npcurcumin	0-10	interleukin 1 beta	Homo sapiens	111-119
30688289-8	2019	RESULTS Aristolochic acid inhibited HK-2 cell viability, induced cell apoptosis, increased the levels of ROS and inflammatory cytokines, including IL-1beta, IL-6, TNF-alpha, and activated the NF-kappaB pathway.	aristolochic acid I	8-25	interleukin 1 beta	Homo sapiens	147-155
30695037-7	2019	Lithium (Li) exposure triggered a short and attenuated inflammatory response demonstrated by elevation of superoxide anion (SA), reactive oxygen species (ROS), IL-1beta, and cellular proliferation followed by elevation of anti-inflammatory IL-10 levels.	Lithium	0-7	interleukin 1 beta	Homo sapiens	160-168
30665457-4	2019	Effects on inhibiting IL-1beta-induced release of arachidonic acid (AA) and prostaglandin E2 (PGE2) were measured using SW982 synoviocyte cells.	Arachidonic Acid	50-66	interleukin 1 beta	Homo sapiens	22-30
30683126-11	2019	Mechanistically, tumor exosomal tri-phosphate RNAs induced the expression of interleukin-1beta (IL-1beta) through a pattern recognition-NF-kappaB signaling axis to sustain neutrophil survival.	Trichloroethylene	32-35	interleukin 1 beta	Homo sapiens	77-94
30683126-11	2019	Mechanistically, tumor exosomal tri-phosphate RNAs induced the expression of interleukin-1beta (IL-1beta) through a pattern recognition-NF-kappaB signaling axis to sustain neutrophil survival.	Trichloroethylene	32-35	interleukin 1 beta	Homo sapiens	96-104
30683126-11	2019	Mechanistically, tumor exosomal tri-phosphate RNAs induced the expression of interleukin-1beta (IL-1beta) through a pattern recognition-NF-kappaB signaling axis to sustain neutrophil survival.	Phosphates	36-45	interleukin 1 beta	Homo sapiens	77-94
30683126-11	2019	Mechanistically, tumor exosomal tri-phosphate RNAs induced the expression of interleukin-1beta (IL-1beta) through a pattern recognition-NF-kappaB signaling axis to sustain neutrophil survival.	Phosphates	36-45	interleukin 1 beta	Homo sapiens	96-104
30697360-11	2019	Furthermore, 10 nM of 1alpha,25(OH)2D3 generally inhibited the IL-6 and IL-1beta-mediated inflammatory responses, and reduced both p44/42 MAPK and relA phosphorylation in MacCM-stimulated preadipocytes.	25(oh)2d3	29-38	interleukin 1 beta	Homo sapiens	72-80
30584213-4	2019	Our results demonstrated that SIRT3 was downregulated in chondrocytes under IL-1beta stimulation, where its expression was positively correlated with mitochondrial damage and reactive oxygen species (ROS) production.	Reactive Oxygen Species	175-198	interleukin 1 beta	Homo sapiens	76-84
30584213-4	2019	Our results demonstrated that SIRT3 was downregulated in chondrocytes under IL-1beta stimulation, where its expression was positively correlated with mitochondrial damage and reactive oxygen species (ROS) production.	Reactive Oxygen Species	200-203	interleukin 1 beta	Homo sapiens	76-84
30584213-5	2019	Metformin treatment upregulated SIRT3 expression and mitigated loss of cell viability and decreased the generation of mitochondria-induced ROS in chondrocytes stimulated with IL-1beta.	Metformin	0-9	interleukin 1 beta	Homo sapiens	175-183
30584213-5	2019	Metformin treatment upregulated SIRT3 expression and mitigated loss of cell viability and decreased the generation of mitochondria-induced ROS in chondrocytes stimulated with IL-1beta.	Reactive Oxygen Species	139-142	interleukin 1 beta	Homo sapiens	175-183
30584213-6	2019	Metformin also attenuated IL-1beta-induced expressions of catabolic genes such as matrix metalloproteinase-3 (MMP3) and MMP13 and enhanced the anabolic indicator Collagen II.	Metformin	0-9	interleukin 1 beta	Homo sapiens	26-34
30584213-9	2019	Overall, our findings provide evidence that metformin suppresses IL-1beta-induced oxidative and osteoarthritis-like inflammatory changes by enhancing the SIRT3/PINK1/Parkin signaling pathway, thereby indicating metformin"s potential in prevention and treatment of osteoarthritic joint disease.	Metformin	44-53	interleukin 1 beta	Homo sapiens	65-73
30584213-9	2019	Overall, our findings provide evidence that metformin suppresses IL-1beta-induced oxidative and osteoarthritis-like inflammatory changes by enhancing the SIRT3/PINK1/Parkin signaling pathway, thereby indicating metformin"s potential in prevention and treatment of osteoarthritic joint disease.	Metformin	211-220	interleukin 1 beta	Homo sapiens	65-73
30665457-4	2019	Effects on inhibiting IL-1beta-induced release of arachidonic acid (AA) and prostaglandin E2 (PGE2) were measured using SW982 synoviocyte cells.	Dinoprostone	76-92	interleukin 1 beta	Homo sapiens	22-30
30665457-4	2019	Effects on inhibiting IL-1beta-induced release of arachidonic acid (AA) and prostaglandin E2 (PGE2) were measured using SW982 synoviocyte cells.	Dinoprostone	94-98	interleukin 1 beta	Homo sapiens	22-30
30234998-14	2019	Consistent with the multifactorial etiology of alcohol-associated liver disease, we identified strong combined effects of HPMA and proinflammatory cytokines (IL-1beta, IL-8, and TNFalpha) on the extent/pattern of liver cell death, thereby supporting the pathogenic role of acrolein.	Alcohols	47-54	interleukin 1 beta	Homo sapiens	158-166
30669636-5	2019	In addition, we determined that DHE-glycoside beta-anomers showed strong inhibitory activity towards pro-inflammatory cytokine mRNA and protein expression, including that of TNF-alpha, IL-6, and IL-1beta- in stimulated HaCaT cells.	dhe-glycoside	32-45	interleukin 1 beta	Homo sapiens	195-203
30395929-5	2019	Heterozygote IL-1beta T-carriers demonstrated poorer switching performance in relation to striatal iron content as compared to IL-1beta C/C counterparts, despite the two groups being of similar age.	Iron	99-103	interleukin 1 beta	Homo sapiens	13-21
30395929-6	2019	With increasing genetic inflammation risk, homozygote IL-1beta T/T carriers had lesser age-related variance in striatal iron content as compared to the other groups but showed a similar association of greater striatal iron content predicting poorer cognitive switching.	Iron	120-124	interleukin 1 beta	Homo sapiens	54-62
30395929-6	2019	With increasing genetic inflammation risk, homozygote IL-1beta T/T carriers had lesser age-related variance in striatal iron content as compared to the other groups but showed a similar association of greater striatal iron content predicting poorer cognitive switching.	Iron	218-222	interleukin 1 beta	Homo sapiens	54-62
30687084-8	2018	In monocytic cells, the effects of [V11L;V16D]ArIB and RgIA4 suggested that activation of nAChRs containing alpha9, alpha7, and/or alpha10 subunits inhibits ATP-induced IL-1beta release.	Adenosine Triphosphate	157-160	interleukin 1 beta	Homo sapiens	169-177
30612459-3	2019	Gouty arthritis is an inflammatory disease characterized by urate crystal-induced NLRP3 inflammasome activation with up-regulated caspase-1 protease and IL-1 beta in macrophages.	Uric Acid	60-65	interleukin 1 beta	Homo sapiens	153-162
30804705-7	2019	Results: Theobromine significantly inhibits the differentiation of preadipocytes in mature adipocytes and reduces the levels of proinflammatory cytokines as MCP-1 and IL-1beta in the supernatants obtained by the mature adipocytes and macrophages interaction.	Theobromine	9-20	interleukin 1 beta	Homo sapiens	167-175
30654825-4	2019	These sheddases are activated by reactive oxygen species and pro-inflammatory cytokines such as tumor necrosis factor alpha and interleukin-1beta.	Reactive Oxygen Species	33-56	interleukin 1 beta	Homo sapiens	128-145
30643177-5	2019	IL-1beta altered the cell cycle (108 genes) and Rho GTPases signaling (72 genes) in chondrocytes, while chondrocyte phenotypic shift was observed with histology, cell volume measurement, and MTT assay.	monooxyethylene trimethylolpropane tristearate	191-194	interleukin 1 beta	Homo sapiens	0-8
30643177-6	2019	IL-1beta inhibited the spontaneous calcium signaling in chondrocytes, a fundamental signaling event in chondrocyte metabolic activities.	Calcium	35-42	interleukin 1 beta	Homo sapiens	0-8
30643177-7	2019	The expression of 24 genes from 6 calcium-signaling related pathways were changed by IL-1beta exposure.	Calcium	34-41	interleukin 1 beta	Homo sapiens	85-93
30641908-0	2019	IL-1beta Inflammatory Cytokine-Induced TP63 Isoform  NP63alpha Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells.	Cisplatin	96-105	interleukin 1 beta	Homo sapiens	0-8
30641908-7	2019	The participation of these processes in the increase of resistance to cisplatin was confirmed by silencing TP63 expression or by inhibition of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) activity in the IL-1beta/IL-1RI/beta-catenin signaling pathway.	Cisplatin	70-79	interleukin 1 beta	Homo sapiens	219-227
30641908-8	2019	These data reinforced the importance of an inflammatory environment in the induction of drug resistance in cancer cells and uncovered a molecular mechanism where the IL-1beta signaling pathway potentiates the acquisition of cisplatin resistance in breast cancer cells.	Cisplatin	224-233	interleukin 1 beta	Homo sapiens	166-174
30391743-0	2019	Casticin protects against IL-1beta-induced inflammation in human osteoarthritis chondrocytes.	casticin	0-8	interleukin 1 beta	Homo sapiens	26-34
30391743-3	2019	In the current study, we examined the anti-inflammatory effects of casticin on chondrocytes exposed to interleukin-1beta (IL-1beta).	casticin	67-75	interleukin 1 beta	Homo sapiens	103-120
30391743-3	2019	In the current study, we examined the anti-inflammatory effects of casticin on chondrocytes exposed to interleukin-1beta (IL-1beta).	casticin	67-75	interleukin 1 beta	Homo sapiens	122-130
30391743-4	2019	Our results demonstrated that casticin treatment significantly improved cell viability in chondrocytes exposed to IL-1beta.	casticin	30-38	interleukin 1 beta	Homo sapiens	114-122
30391743-5	2019	Casticin significantly inhibited IL-1beta-induced NO and PGE2 production, and iNOS and COX-2 expression in human OA chondrocytes.	casticin	0-8	interleukin 1 beta	Homo sapiens	33-41
30391743-5	2019	Casticin significantly inhibited IL-1beta-induced NO and PGE2 production, and iNOS and COX-2 expression in human OA chondrocytes.	Dinoprostone	57-61	interleukin 1 beta	Homo sapiens	33-41
30391743-7	2019	Furthermore, casticin prevented IL-1beta-induced NF-kappaB activation in chondrocytes.	casticin	13-21	interleukin 1 beta	Homo sapiens	32-40
30391743-8	2019	Taken together, these findings showed that casticin attenuates inflammatory responses in chondrocytes stimulated with IL-1beta, possibly through the NF-kappaB signaling pathway.	casticin	43-51	interleukin 1 beta	Homo sapiens	118-126
30740538-6	2019	A modest decline in intracellular ATP or pH within an optimal range induces maximum IL-1beta release while their excessive decline suppresses IL-1beta release.	Adenosine Triphosphate	34-37	interleukin 1 beta	Homo sapiens	84-92
30399583-8	2019	Moreover, teneligliptin suppressed H/R-induced cytokine production and production of vascular adhesion molecules such as IL-1beta, TNF-alpha and ICAM-1.	3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine	10-23	interleukin 1 beta	Homo sapiens	121-129
30360768-3	2019	PE from EVOO treatment inhibited IL-1beta-induced matrix metalloproteases (P&amp;lt;0 001), TNF-alpha and IL-6 production (P&amp;lt;0 001).	evoo	8-12	interleukin 1 beta	Homo sapiens	33-41
31582650-4	2019	2FL reduced PM10-induced excess expression of interleukin (IL)-6, IL-8, IL-1alpha and IL-1beta in HaCaT keratinocytes.	2'-fucosyllactose	0-3	interleukin 1 beta	Homo sapiens	86-94
30551489-6	2019	Furthermore, icariin pretreatment reduced NF-kappaB phosphorylation and nuclear translocation in HEK-293 cells followed by decreased secretion of IL-1beta, TNF-alpha, and iNOS, suggesting a suppression of inflammatory response.	icariin	13-20	interleukin 1 beta	Homo sapiens	146-154
30551507-3	2019	Here, we investigated the anti-inflammatory and chondroprotective effects of ACY-1215 in IL-1beta-stimulated human primary chondrocytes and C28/I2 cells.	ricolinostat	77-85	interleukin 1 beta	Homo sapiens	89-97
30551507-4	2019	The results suggested that ACY-1215 can markedly suppress the expression of inflammatory factors, including IL-1beta and IL-6 in human primary chondrocytes and C28/I2 cells.	ricolinostat	27-35	interleukin 1 beta	Homo sapiens	108-116
30360768-3	2019	PE from EVOO treatment inhibited IL-1beta-induced matrix metalloproteases (P&amp;lt;0 001), TNF-alpha and IL-6 production (P&amp;lt;0 001).	Adenosine Monophosphate	77-80	interleukin 1 beta	Homo sapiens	33-41
30383980-7	2019	Ambroxol mitigated cisplatin inflammatory damage by inhibition of tumor necrosis factor-alpha, interleukin-1beta, and nuclear factor kappa-B and elevation of nuclear factor erythroid 2-related factor 2.	Ambroxol	0-8	interleukin 1 beta	Homo sapiens	95-112
31411316-0	2019	Ginsenoside Rd inhibits IL-1beta-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination.	Ginsenosides	0-11	interleukin 1 beta	Homo sapiens	24-32
30389501-12	2019	In summary, we have demonstrated that SREBP-1 could be a key player in oxLDL-induced excessive lipid accumulation leading to macrophage FCF via ROS-mediated NLRP3/IL-1beta/SREBP-1 pathway.	Reactive Oxygen Species	144-147	interleukin 1 beta	Homo sapiens	163-171
31319406-2	2019	Lipopolysaccharide-induced Toll-like receptor activation causes metabolic disturbances that are triggered by increased succinate levels and hypoxia inducible factors, which results in inflammation via IL-1beta activation.	Succinic Acid	119-128	interleukin 1 beta	Homo sapiens	201-209
30704983-11	2019	Hypoxia reduced iron deprivation-associated TNF and IL1beta expression in HT-29 cells through the induction of autophagy.	Iron	16-20	interleukin 1 beta	Homo sapiens	52-59
30520054-4	2019	Our results demonstrated that metformin significantly decreased the mRNA and protein levels of tumour necrosis factor-alpha (TNFalpha), interleukin (IL)-6, IL-8, and IL-1beta induced by TNFalpha.	Metformin	30-39	interleukin 1 beta	Homo sapiens	166-174
30704983-13	2019	Iron blocked autophagy in Caco-2 cells, while reducing hypoxia-associated TNF and IL1beta expression through the inhibition of NF-kappaB binding to the promoter of TNF and IL1beta.	Iron	0-4	interleukin 1 beta	Homo sapiens	82-89
30704983-13	2019	Iron blocked autophagy in Caco-2 cells, while reducing hypoxia-associated TNF and IL1beta expression through the inhibition of NF-kappaB binding to the promoter of TNF and IL1beta.	Iron	0-4	interleukin 1 beta	Homo sapiens	172-179
31261155-0	2019	Anti-Apoptotic Effects of Docosahexaenoic Acid in IL-1beta-Induced Human Chondrosarcoma Cell Death through Involvement of the MAPK Signaling Pathway.	Docosahexaenoic Acids	26-46	interleukin 1 beta	Homo sapiens	50-58
30360750-2	2019	This study was conducted to investigate the possible association between interleukin-1beta (IL-1beta) rs16944 /IL-1 receptor antagonist (IL-1Ra) VNTR variants and genetic susceptibility to DPN in a Turkish cohort.	dpn	189-192	interleukin 1 beta	Homo sapiens	73-90
31261155-7	2019	In contrast, DHA inhibits the expression of IL-1beta, inhibits IL-1beta-induced cell apoptosis, and has a certain inhibitory effect on the activation of the MAPK signaling pathway.	Docosahexaenoic Acids	13-16	interleukin 1 beta	Homo sapiens	44-52
31261155-7	2019	In contrast, DHA inhibits the expression of IL-1beta, inhibits IL-1beta-induced cell apoptosis, and has a certain inhibitory effect on the activation of the MAPK signaling pathway.	Docosahexaenoic Acids	13-16	interleukin 1 beta	Homo sapiens	63-71
31333000-0	2019	Melatonin Receptor 1beta Gene Polymorphism rs10830963, Serum Melatonin, TNF-alpha, IL-6, IL-1beta, in Egyptian Patients with Systemic Lupus Erythematosus.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	89-97
30360750-2	2019	This study was conducted to investigate the possible association between interleukin-1beta (IL-1beta) rs16944 /IL-1 receptor antagonist (IL-1Ra) VNTR variants and genetic susceptibility to DPN in a Turkish cohort.	dpn	189-192	interleukin 1 beta	Homo sapiens	92-100
30360750-13	2019	CONCLUSION: Findings of this study indicated that the IL-1beta rs16944 and IL-1Ra VNTR variants are probably to be associated with susceptibility DPN risk in a Turkish cohort.	dpn	146-149	interleukin 1 beta	Homo sapiens	54-62
31416412-11	2019	CONCLUSION: ATV inhibited ROS generation and activated IL-1 beta/IL-6 secretion in PBMNC of diabetes patients.	Atorvastatin	12-15	interleukin 1 beta	Homo sapiens	55-64
31416412-0	2019	Atorvastatin Inhibited ROS Generation and Increased IL-1beta And IL-6 Release by Mononuclear Cells from Diabetic Patients.	Atorvastatin	0-12	interleukin 1 beta	Homo sapiens	52-60
30114392-11	2019	In YHES cells, only DEX but not the progestins under study exerted a significant down-regulating effect (-79%, p&lt;.01) on COX-2 mRNA after IL-1beta stimulation.	Dexamethasone	20-23	interleukin 1 beta	Homo sapiens	141-149
30273577-6	2019	Results showed that palmitate robustly stimulated the expression of proinflammatory cytokines including interleukin (IL)-6 and IL-1beta, and the combination of palmitate and LPS further upregulated the proinflammatory cytokines by cooperatively stimulating inflammatory signaling pathways.	Palmitates	20-29	interleukin 1 beta	Homo sapiens	127-135
30471618-2	2019	Our previous study has demonstrated that in human peritoneal mesothelial cells (HPMCs), exposure to high glucose-based peritoneal dialysis (PD) solutions induced mitochondrial reactive oxygen species (ROS) production, activation of NLRP3 inflammasome and IL-1beta expression.	Glucose	105-112	interleukin 1 beta	Homo sapiens	255-263
30445309-7	2019	Bilobalide also prevented the infiltration of CD4+ T cells, CD68+ macrophages and B220+ B cells within the brain, and reduced the inflammatory microenvironment mediated with Iba1+iNOS+ and Iba1+NF-kB+ microglia after CPZ challenge, accompanied by the inhibition of IL-1beta and IL-6 in the brain.	bilobalide	0-10	interleukin 1 beta	Homo sapiens	265-273
30431058-8	2019	The results of the in vivo experiments revealed that propofol inhibits the abnormal proliferation of microglia, as well as reduces the expression levels of interleukin (IL)-6, IL-1beta, tumor necrosis factor alpha, and the cytotoxic factor nitric oxide through the A2b receptor.	Propofol	53-61	interleukin 1 beta	Homo sapiens	176-184
30662325-6	2019	Then low doses of both ALN and ZOL rapidly increased the release of the pro-inflammatory mediators TNFalpha and IL-1beta, while increased DKK-1 and Sclerostin, both inhibitors of osteoblastogenesis.	Alendronate	23-26	interleukin 1 beta	Homo sapiens	112-120
30662325-6	2019	Then low doses of both ALN and ZOL rapidly increased the release of the pro-inflammatory mediators TNFalpha and IL-1beta, while increased DKK-1 and Sclerostin, both inhibitors of osteoblastogenesis.	Zoledronic Acid	31-34	interleukin 1 beta	Homo sapiens	112-120
29857009-10	2019	In Study 3 neutrophils and monocytes released IL-1beta when challenged with a combination of palmitic acid and LPS or TNF-alpha.	Palmitic Acid	93-106	interleukin 1 beta	Homo sapiens	46-54
30246263-7	2019	Meanwhile, treating the cells with sodium hydrosulfide (NaHS) inhibited the productions of IL-1beta and IL-18.	sodium bisulfide	35-54	interleukin 1 beta	Homo sapiens	91-99
30246263-7	2019	Meanwhile, treating the cells with sodium hydrosulfide (NaHS) inhibited the productions of IL-1beta and IL-18.	sodium bisulfide	56-60	interleukin 1 beta	Homo sapiens	91-99
30246263-8	2019	Furthermore, upregulation of H 2 S synthesis by treating the cells with NaHS also reduced the protein levels of TXNIP, NLRP3, ASC, caspase-1, and IL-1beta.	Hydrogen Sulfide	29-34	interleukin 1 beta	Homo sapiens	146-154
30246263-8	2019	Furthermore, upregulation of H 2 S synthesis by treating the cells with NaHS also reduced the protein levels of TXNIP, NLRP3, ASC, caspase-1, and IL-1beta.	sodium bisulfide	72-76	interleukin 1 beta	Homo sapiens	146-154
30246263-11	2019	CONCLUSION: In summary, the present finding suggested a possible linkage between H 2 S metabolism and AS through the H 2 S/CSE-TXNIP-NLRP3-IL-18/IL-1beta-nitric oxide (NO) signaling pathway.	Nitric Oxide	154-166	interleukin 1 beta	Homo sapiens	145-153
31146075-11	2019	In particular, 0.5 g of tungsten showed a significant rise of IL-6 which could also be found for IL-1beta and IL-8.	Tungsten	24-32	interleukin 1 beta	Homo sapiens	97-105
30521963-6	2019	Also, we found that ivabradine inhibited the expression and secretion of interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) as well as the production of reactive oxygen species (ROS).	Ivabradine	20-30	interleukin 1 beta	Homo sapiens	98-115
30521963-6	2019	Also, we found that ivabradine inhibited the expression and secretion of interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) as well as the production of reactive oxygen species (ROS).	Ivabradine	20-30	interleukin 1 beta	Homo sapiens	117-125
30365050-8	2019	In addition, cotreatment with the COX2 inhibitor CAY10404 and sesamin downregulated the expression of downstream molecules of COX2 [including interleukin (IL)1beta, IL6 and tumor necrosis factor alpha] compared with CAY10404 or sesamin alone.	3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole	49-57	interleukin 1 beta	Homo sapiens	142-163
30365050-8	2019	In addition, cotreatment with the COX2 inhibitor CAY10404 and sesamin downregulated the expression of downstream molecules of COX2 [including interleukin (IL)1beta, IL6 and tumor necrosis factor alpha] compared with CAY10404 or sesamin alone.	sesamin	62-69	interleukin 1 beta	Homo sapiens	142-163
30471618-9	2019	Furthermore, the application of a ROS inhibitor (APDC) to HPMCs blocked the high glucose-based PD solution-induced TXNIP-NLRP3 binding, in addition to ROS production and IL-1beta expression.	Reactive Oxygen Species	34-37	interleukin 1 beta	Homo sapiens	170-178
30471618-9	2019	Furthermore, the application of a ROS inhibitor (APDC) to HPMCs blocked the high glucose-based PD solution-induced TXNIP-NLRP3 binding, in addition to ROS production and IL-1beta expression.	Ammonium pyrrolidyldithiocarbamate	49-53	interleukin 1 beta	Homo sapiens	170-178
30471618-9	2019	Furthermore, the application of a ROS inhibitor (APDC) to HPMCs blocked the high glucose-based PD solution-induced TXNIP-NLRP3 binding, in addition to ROS production and IL-1beta expression.	Glucose	81-88	interleukin 1 beta	Homo sapiens	170-178
30476824-9	2019	A S1PR1 antagonist (W146) and NF-kappaB inhibitor (BAY11-7082) inhibited S1P-induced TNF-alpha and IL-1beta secretion and prevented NF-kappaB nuclear translocation.	W146	20-24	interleukin 1 beta	Homo sapiens	99-107
30476824-9	2019	A S1PR1 antagonist (W146) and NF-kappaB inhibitor (BAY11-7082) inhibited S1P-induced TNF-alpha and IL-1beta secretion and prevented NF-kappaB nuclear translocation.	3-(4-methylphenylsulfonyl)-2-propenenitrile	51-61	interleukin 1 beta	Homo sapiens	99-107
30703176-1	2019	AIMS: To elucidate the role of Link N in regulating inflammatory molecules from human mesenchymal stem cells (hMSCs) under interleukin (IL)-1beta stimulation in vitro and under Complete Freund"s Adjuvant (CFA)-induced arthritis of the temporomandibular joint (TMJ) in vivo.	Nitrogen	36-37	interleukin 1 beta	Homo sapiens	123-145
30842373-5	2019	We observed the activation of caspase-1 and production of IL-1beta after exposure of THP-1 cells to 2,4-dinitrochlorobenzene (DNCB, sensitizer), octanoic acid (OA, non-sensitizer), and salicylic acid (SA, non-sensitizer), implying NLRP3 activation.	Dinitrochlorobenzene	100-124	interleukin 1 beta	Homo sapiens	58-66
30726810-11	2019	administration of a H2S donor, through NF-kappaB-TNFalpha/IL-1beta-MuUC1/5B pathway.	Hydrogen Sulfide	20-23	interleukin 1 beta	Homo sapiens	58-66
30726812-6	2019	Furthermore, the protein expression of pyroptosis (Cleaved Caspase-1, NO, IL-1beta, IL-18), as well as LDH and the relative electrical conductivity were significantly augmented by BaP.	benzylaminopurine	180-183	interleukin 1 beta	Homo sapiens	74-82
30842373-5	2019	We observed the activation of caspase-1 and production of IL-1beta after exposure of THP-1 cells to 2,4-dinitrochlorobenzene (DNCB, sensitizer), octanoic acid (OA, non-sensitizer), and salicylic acid (SA, non-sensitizer), implying NLRP3 activation.	Salicylic Acid	185-199	interleukin 1 beta	Homo sapiens	58-66
30842373-5	2019	We observed the activation of caspase-1 and production of IL-1beta after exposure of THP-1 cells to 2,4-dinitrochlorobenzene (DNCB, sensitizer), octanoic acid (OA, non-sensitizer), and salicylic acid (SA, non-sensitizer), implying NLRP3 activation.	Dinitrochlorobenzene	126-130	interleukin 1 beta	Homo sapiens	58-66
30842373-5	2019	We observed the activation of caspase-1 and production of IL-1beta after exposure of THP-1 cells to 2,4-dinitrochlorobenzene (DNCB, sensitizer), octanoic acid (OA, non-sensitizer), and salicylic acid (SA, non-sensitizer), implying NLRP3 activation.	Salicylic Acid	201-203	interleukin 1 beta	Homo sapiens	58-66
30842373-5	2019	We observed the activation of caspase-1 and production of IL-1beta after exposure of THP-1 cells to 2,4-dinitrochlorobenzene (DNCB, sensitizer), octanoic acid (OA, non-sensitizer), and salicylic acid (SA, non-sensitizer), implying NLRP3 activation.	octanoic acid	145-158	interleukin 1 beta	Homo sapiens	58-66
29619614-7	2019	We found that TNFalpha and IL-1beta suppress synaptosomal cLTP.	cltp	58-62	interleukin 1 beta	Homo sapiens	27-35
30500626-6	2019	Furthermore, Magnolol significantly reduced the gene expression and protein release of IL-1beta and TNF-alpha.	magnolol	13-21	interleukin 1 beta	Homo sapiens	87-95
30088187-7	2019	Liraglutide protected cells against the neurotoxicity of mipafox by increasing neuritogenesis, the uptake of glucose, the levels of cytoskeleton proteins, and synaptic-plasticity modulators, besides decreasing the pro-inflammatory cytokine interleukin 1beta and caspase-3 activity.	mipafox	57-64	interleukin 1 beta	Homo sapiens	240-257
30366102-6	2019	CapNO inhibits platelet- or interleukin (IL)-1beta-mediated adhesion between HT29 and endothelial cells, and micrometastatic formation in the lungs of immunocompetent syngeneic mouse models.	capno	0-5	interleukin 1 beta	Homo sapiens	28-50
31814545-5	2019	Some flavonoids exert anti-inflammatory effects through: Blockade of NF-kappaB, and NLRP3 inflammasome, inhibition of pro-inflammatory cytokine production, IL-1beta, IL-2, IL-6, TNF-alpha, IL-17A, down regulation of chemokines, and reduction of reactive oxygen and nitrogen species.	Flavonoids	5-15	interleukin 1 beta	Homo sapiens	156-164
30368040-7	2019	Oxidation of SDHA in sh126B cells was attenuated, while pharmacological inhibition of SDH by atpenin A5 restored IL-1beta expression in sh126B cells upon LPS-treatment.	atpenin A5	93-103	interleukin 1 beta	Homo sapiens	113-121
30798809-7	2019	Relationships between increased production of IL-1beta and dysregulated iron metabolism have been suggested in various diseases, which may be linked to overproduction of hepcidin.	Iron	72-76	interleukin 1 beta	Homo sapiens	46-54
31550730-8	2019	Both BCA and CA decreased P-SQ-induced IL-1beta secretion in HaCaT cells.	Caffeic Acids	5-8	interleukin 1 beta	Homo sapiens	39-47
30587224-6	2018	The generated hypothesis involves interleukin-1 beta (IL-1 beta) and glutamate, and suggests that IL-1 beta influence on glutamate levels is involved in the etiology of both epilepsy and inflammatory bowel disease.	Glutamic Acid	69-78	interleukin 1 beta	Homo sapiens	98-107
30991399-7	2019	RESULTS: OZOILE and steroid topical treatment produced a similar reduction of TNF-alpha and IL-1beta mRNA levels in foreskins from patients with LS when compared to untreated patients (p &lt; 0.001).	ozoile	9-15	interleukin 1 beta	Homo sapiens	92-100
30991399-7	2019	RESULTS: OZOILE and steroid topical treatment produced a similar reduction of TNF-alpha and IL-1beta mRNA levels in foreskins from patients with LS when compared to untreated patients (p &lt; 0.001).	Steroids	20-27	interleukin 1 beta	Homo sapiens	92-100
30355733-4	2018	The Arg-232 pocket was computationally screened for small-molecule binding aimed at IL1B transcription inhibition, yielding l-arginine, a known anti-inflammatory amino acid, revealing a potential for disrupting the C/EBPbeta-Spi1 interaction.	Arginine	4-7	interleukin 1 beta	Homo sapiens	84-88
30355733-4	2018	The Arg-232 pocket was computationally screened for small-molecule binding aimed at IL1B transcription inhibition, yielding l-arginine, a known anti-inflammatory amino acid, revealing a potential for disrupting the C/EBPbeta-Spi1 interaction.	Arginine	124-134	interleukin 1 beta	Homo sapiens	84-88
30355733-5	2018	As evaluated by ChIP, cultured lipopolysaccharide (LPS)-activated THP-1 cells incubated with l-arginine had significantly decreased IL1B transcription and reduced C/EBPbeta"s association with Spi1 on the IL1B promoter.	Arginine	93-103	interleukin 1 beta	Homo sapiens	132-136
30355733-5	2018	As evaluated by ChIP, cultured lipopolysaccharide (LPS)-activated THP-1 cells incubated with l-arginine had significantly decreased IL1B transcription and reduced C/EBPbeta"s association with Spi1 on the IL1B promoter.	Arginine	93-103	interleukin 1 beta	Homo sapiens	204-208
30616781-8	2019	Furthermore, CAFs co-cultured with SAS, a poorly differentiated OSCC cell line, or stimulated with IL-1beta exhibit increased CXCL1 secretion in an NF-kappaB-dependent manner.	cafs	13-17	interleukin 1 beta	Homo sapiens	99-107
30616781-11	2019	CONCLUSION: The induction of IL-1beta following CXCL1 stimulation of CAFs mediates cancer cell invasion, and there is a reciprocal dependency between CAFs and cancer cells in the OSCC microenvironment.	cafs	69-73	interleukin 1 beta	Homo sapiens	29-37
30587224-6	2018	The generated hypothesis involves interleukin-1 beta (IL-1 beta) and glutamate, and suggests that IL-1 beta influence on glutamate levels is involved in the etiology of both epilepsy and inflammatory bowel disease.	Glutamic Acid	121-130	interleukin 1 beta	Homo sapiens	98-107
30643045-5	2018	ATP at low concentration (5 mumol/L) significantly inhibited LPS-induced mRNA expression of IL-1beta, MCP-1 and ICAM-1(P&lt;0.05), downregulated the LPS-induced protein expression of TLR4, MyD88 and CD14 in EPCs (P&lt;0.05), and suppressed LPS-induced activation of NF-kappaB signaling pathway (P&lt;0.05).	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	92-100
30322551-0	2018	A disposable and ultrasensitive ITO based biosensor modified by 6-phosphonohexanoic acid for electrochemical sensing of IL-1beta in human serum and saliva.	6-phosphonohexanoic Acid	64-88	interleukin 1 beta	Homo sapiens	120-128
30322551-3	2018	Anti-IL-1beta antibody was utilized as a biorecognition molecule that immobilized onto carboxyl groups of 6-phosphohexanoic acid (PHA) via amide bond.	SCHEMBL1443018	106-128	interleukin 1 beta	Homo sapiens	5-13
30322551-3	2018	Anti-IL-1beta antibody was utilized as a biorecognition molecule that immobilized onto carboxyl groups of 6-phosphohexanoic acid (PHA) via amide bond.	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-hexanoylamine	130-133	interleukin 1 beta	Homo sapiens	5-13
30322551-3	2018	Anti-IL-1beta antibody was utilized as a biorecognition molecule that immobilized onto carboxyl groups of 6-phosphohexanoic acid (PHA) via amide bond.	Amides	139-144	interleukin 1 beta	Homo sapiens	5-13
30404814-7	2018	LPS or nigericin stimulation of PLAC8-overexpressing human monocytic cell line (THP-1), but not mock THP-1 cells, was associated with a significant decrease in IL-1beta and IL-18 production.	Nigericin	7-16	interleukin 1 beta	Homo sapiens	160-168
30662368-8	2018	Significant changes were observed in fluoxetine treatment compared to baseline: proinflammatory cytokines IFN-gamma, IL-1beta, TNF-alpha, IL-6, IL-12, and IL-15 were decreased only at week 4 whereas IL-2 was increased only at week 8; anti-inflammatory cytokines IL-4 and IL-5 were increased at week 8 while IL-1Ra was reduced only at week 4.	Fluoxetine	37-47	interleukin 1 beta	Homo sapiens	117-125
30316679-4	2018	The treatment with dexamethasone decreased the severity of seizures, also decreased TNF-alpha and Interleukin 1 beta levels in the hippocampus and TNF-alpha level in the serum.	Dexamethasone	19-32	interleukin 1 beta	Homo sapiens	98-116
28899203-6	2018	In addition to the well-established ROS-dependent pathway, recent studies have provided evidence of the direct repression of the transcription of pro-inflammatory cytokine genes, such as IL1b and IL6 (encoding Interleukin-1beta and Interleukin-6, respectively).	Reactive Oxygen Species	36-39	interleukin 1 beta	Homo sapiens	187-191
30029111-9	2018	This enhanced ROS inflicted severe inflammation and subsequent fibrosis, evident from increased pro-inflammatory-cum-fibrogenic cytokines generation (IL-1beta, IL-2, IL-6, TNF-alpha and TGF-beta).	ros	14-17	interleukin 1 beta	Homo sapiens	150-158
28899203-6	2018	In addition to the well-established ROS-dependent pathway, recent studies have provided evidence of the direct repression of the transcription of pro-inflammatory cytokine genes, such as IL1b and IL6 (encoding Interleukin-1beta and Interleukin-6, respectively).	Reactive Oxygen Species	36-39	interleukin 1 beta	Homo sapiens	210-227
28987470-10	2018	Messenger RNA (mRNA) of the Nuclear Factor kappa beta (NF-kappaB) and its target genes InterLeukin 1 beta (IL-1beta) and IL-6 was downregulated significantly (p < 0.05) in leukocytes from DMD boys supplemented with omega-3 long chain-PUFA for 6 months, compared to the placebo group.	omega-3	215-222	interleukin 1 beta	Homo sapiens	87-105
30544610-8	2018	In conclusion, for cinnamaldehyde-related compounds to suppress NLRP3 inflammasome-mediated IL-1beta secretion, the propenal group of the side chain was essential, while the substituted group of the aromatic ring played a modifying role.	cinnamaldehyde	19-33	interleukin 1 beta	Homo sapiens	92-100
30544610-9	2018	Cinnamaldehyde and 2-methoxy cinnamaldehyde exerted dual abilities to inhibit canonical IL-1beta secretion at both stages of priming and activation.	cinnamaldehyde	0-14	interleukin 1 beta	Homo sapiens	88-96
30544610-9	2018	Cinnamaldehyde and 2-methoxy cinnamaldehyde exerted dual abilities to inhibit canonical IL-1beta secretion at both stages of priming and activation.	2-methoxycinnamaldehyde	19-43	interleukin 1 beta	Homo sapiens	88-96
30563042-5	2018	H2O2 at a high concentration enhances the expression of pro-inflammatory genes (TLR2 and IL1beta) and diminishes the expression of mitochondrial dynamics-related proteins (Mtf1, Tfam) and antioxidant enzymes (Cu/Zn SOD) in PBMCs.	Hydrogen Peroxide	0-4	interleukin 1 beta	Homo sapiens	89-96
30627059-11	2018	In face of lipopolysaccharide (LPS) stimulation, Primovist , Omniscan , and Magnevist  groups exhibited elevated nitrite/nitrate and suppressed IL-1beta secretion and IL-6 and IL-10 secretion.	gadodiamide	61-69	interleukin 1 beta	Homo sapiens	144-152
30207171-8	2018	Podocytes demonstrate a reduction in the area covered by filamentous-actin in response to IL-1beta treatment within 1 h ( P = 0.011), which is restored by 24 h, associated with an increase in the level of intracellular calcium but not with increased cell death.	Calcium	219-226	interleukin 1 beta	Homo sapiens	90-98
30155554-4	2018	The exopolysaccharide promoted the phagocytosis of bacterial cells, activated metabolic processes in human and animal leukocytes, and moderately affected the production of TNF-alpha and IL-1beta.	exopolysaccharide	4-21	interleukin 1 beta	Homo sapiens	186-194
30236770-9	2018	The inhibition of ROS production decreased NLRP3 inflammasome activation and IL-1beta production in CD4 T cells, leading to the suppression of Th17 differentiation.	ros	18-21	interleukin 1 beta	Homo sapiens	77-85
30544610-0	2018	Structural Moieties Required for Cinnamaldehyde-Related Compounds to Inhibit Canonical IL-1beta Secretion.	cinnamaldehyde	33-47	interleukin 1 beta	Homo sapiens	87-95
30544610-2	2018	This study aimed to find out the functional group responsible for the inhibitory effects of cinnamaldehyde-related compounds on the canonical IL-1beta secretion.	cinnamaldehyde	92-106	interleukin 1 beta	Homo sapiens	142-150
30544610-4	2018	At concentrations of 25~100 muM, cinnamaldehyde and 2-methoxy cinnamaldehyde dose-dependently inhibited IL-1beta secretion.	cinnamaldehyde	33-47	interleukin 1 beta	Homo sapiens	104-112
30544610-4	2018	At concentrations of 25~100 muM, cinnamaldehyde and 2-methoxy cinnamaldehyde dose-dependently inhibited IL-1beta secretion.	2-methoxycinnamaldehyde	52-76	interleukin 1 beta	Homo sapiens	104-112
30544610-6	2018	Furthermore, cinnamaldehyde and 2-methoxy cinnamaldehyde diminished expressions of NLRP3 and pro-IL-1beta.	cinnamaldehyde	13-27	interleukin 1 beta	Homo sapiens	93-105
30544610-6	2018	Furthermore, cinnamaldehyde and 2-methoxy cinnamaldehyde diminished expressions of NLRP3 and pro-IL-1beta.	2-methoxycinnamaldehyde	32-56	interleukin 1 beta	Homo sapiens	93-105
30571257-0	2018	Dysregulated IL-1beta-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine.	Hydroxychloroquine	78-96	interleukin 1 beta	Homo sapiens	13-21
30571257-9	2018	We provide evidence that interleukin-1beta amplifies the expansion of GM-CSF-expressing CD4 T cells, which is effectively suppressed by hydroxychloroquine.	Hydroxychloroquine	136-154	interleukin 1 beta	Homo sapiens	25-42
30627059-11	2018	In face of lipopolysaccharide (LPS) stimulation, Primovist , Omniscan , and Magnevist  groups exhibited elevated nitrite/nitrate and suppressed IL-1beta secretion and IL-6 and IL-10 secretion.	Gadolinium DTPA	76-85	interleukin 1 beta	Homo sapiens	144-152
30372880-10	2018	Furthermore, in vitro studies demonstrated that AJE inhibits TNF-alpha-induced IL-8, IL-1beta, and COX-2 expression in human intestinal epithelial HT-29 cells and tert-butyl hydroperoxide-induced reduction of ZO-1 and occludin expression in human intestinal epithelial Caco-2 cells.	aje	48-51	interleukin 1 beta	Homo sapiens	85-93
30247270-1	2018	OBJECTIVES: Monocytes and macrophages produce interleukin-1beta by inflammasome activation which involves adenosine triphosphate release, pannexin-1 channels, and <protein-id="3553">P2X7 receptors.	Adenosine Triphosphate	106-128	interleukin 1 beta	Homo sapiens	46-63
30134219-15	2018	Both curcumin-loaded liposomes formulation (1 mug/mL, 5 mug/mL) resulted in significant (p &lt; 0.05) reduction in the level of pro-inflammatory marker expression such as IL-6, IL-8, IL-1beta and TNF-a compared to positive control group.	Curcumin	5-13	interleukin 1 beta	Homo sapiens	183-191
30427314-12	2018	RESULTS: Compared with titanium particles with adherent bacterial debris, endotoxin-free titanium particles induced 86% less NLRP3 mRNA (0.05 +- 0.03 versus 0.35 +- 0.01 NLRP3/GAPDH, p &lt; 0.001) and 91% less IL1beta mRNA (0.02 +- 0.01 versus 0.22 +- 0.03 IL1beta/GAPDH, p &lt; 0.001).	Titanium	89-97	interleukin 1 beta	Homo sapiens	210-217
30427314-12	2018	RESULTS: Compared with titanium particles with adherent bacterial debris, endotoxin-free titanium particles induced 86% less NLRP3 mRNA (0.05 +- 0.03 versus 0.35 +- 0.01 NLRP3/GAPDH, p &lt; 0.001) and 91% less IL1beta mRNA (0.02 +- 0.01 versus 0.22 +- 0.03 IL1beta/GAPDH, p &lt; 0.001).	Titanium	89-97	interleukin 1 beta	Homo sapiens	257-264
30247270-10	2018	Inhibition of mitochondria, adenosine triphosphate release, or P2 receptors blocked p38 mitogen-activated protein kinase and caspase-1 activation and interleukin-1beta secretion.	Adenosine Triphosphate	28-50	interleukin 1 beta	Homo sapiens	150-167
30247270-0	2018	Adenosine Triphosphate Release is Required for Toll-Like Receptor-Induced Monocyte/Macrophage Activation, Inflammasome Signaling, Interleukin-1beta Production, and the Host Immune Response to Infection.	Adenosine Triphosphate	0-22	interleukin 1 beta	Homo sapiens	130-147
30326332-3	2018	We aimed to determine the relationship between LEV concentrations and its therapeutic response, and the effect of LEV on IL1-beta concentrations in patients with epilepsy.	Levetiracetam	114-117	interleukin 1 beta	Homo sapiens	121-129
30340925-12	2018	Moreover, TNF-alpha, IL-1 and IL-6 can induce the production of other cytokines, matrix metalloproteinases (MMPs) and prostaglandins and inhibit the synthesis of proteoglycans and type II collagen; thus, they play a pivotal role in cartilage matrix degradation and bone resorption in OA.	Prostaglandins	118-132	interleukin 1 beta	Homo sapiens	21-25
29098425-8	2018	RESULTS: Before and after the intervention with the SFA-enriched breakfast, this meal test induced a higher relative postprandial IL-1beta expression compared to the responses to the unSFA and fiber-enriched meal (p = 0.02).	Fatty Acids	52-55	interleukin 1 beta	Homo sapiens	130-138
29098425-11	2018	CONCLUSIONS: Our findings indicated that a single SFA-enriched meal is able to acutely induce the IL-1beta expression and regularly consumed could trigger systemic inflammation, while increased unSFA consumption could attenuate the inflammatory status.	Fatty Acids	50-53	interleukin 1 beta	Homo sapiens	98-106
30326332-11	2018	A statistically significant decrease was found in the IL1-beta concentration to LEV (C/D) ratio with the increase in LEV concentration in patients on LEV monotherapy.	Levetiracetam	80-83	interleukin 1 beta	Homo sapiens	54-62
30326332-11	2018	A statistically significant decrease was found in the IL1-beta concentration to LEV (C/D) ratio with the increase in LEV concentration in patients on LEV monotherapy.	Levetiracetam	117-120	interleukin 1 beta	Homo sapiens	54-62
30326332-11	2018	A statistically significant decrease was found in the IL1-beta concentration to LEV (C/D) ratio with the increase in LEV concentration in patients on LEV monotherapy.	Levetiracetam	117-120	interleukin 1 beta	Homo sapiens	54-62
30380512-4	2018	Osthole repressed ox-LDL-induced release of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 in HUVECs.	osthol	0-7	interleukin 1 beta	Homo sapiens	85-107
30003820-8	2018	In contrast, supplementation with CoQ10 significantly recovered mitochondrial function and concurrently decreased the generation of reactive oxygen species and lipid peroxides, inhibited the accumulation of lipid droplets and the formation of the NOD-like receptor family pyrin domain-containing three (NLRP3) inflammasome, and reduced interleukin-1beta release and cell death.	coenzyme Q10	34-39	interleukin 1 beta	Homo sapiens	336-353
30088170-9	2018	In vitro experiments showed that the levels of TNF-alpha, IL-1beta, and IL-6 secreted by human pulmonary microvascular endothelial cells treated with PQ were attenuated by fasudil.	Paraquat	150-152	interleukin 1 beta	Homo sapiens	58-66
30316071-0	2018	Methylsulfonylmethane and mobilee prevent negative effect of IL-1beta in human chondrocyte cultures via NF-kappaB signaling pathway.	dimethyl sulfone	0-21	interleukin 1 beta	Homo sapiens	61-69
30320369-7	2018	The results revealed that Evo dose-dependently reduced the protein and mRNA expression levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta, and inhibited the levels of phosphorylated (p-) inhibitor of NF-kappaBalpha, p-extracellular signal-regulated kinase, p-c-Jun N-terminal kinase and p-p38, and decreased the nuclear translocation of NF-kappaB/p65 in BEAS-2B cells infected with MSSA.	evodiamine	26-29	interleukin 1 beta	Homo sapiens	155-163
30316071-11	2018	Co-treatment of IL-1beta with mobilee, MSM and BAY11-7082 didn"t cause changes of MMPs or Col2a1 beyond that caused by each single treatment.	3-(4-methylphenylsulfonyl)-2-propenenitrile	47-57	interleukin 1 beta	Homo sapiens	16-24
30713180-1	2018	AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1beta, TNF-alpha, and PGE2.	Glucosamine	33-44	interleukin 1 beta	Homo sapiens	218-226
30320365-6	2018	Baicalin alleviated inflammation injury and inhibited the secretion of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, thus suppressing nuclear factor (NF)-kB-p65 activation via inhibition of IkB kinase.	baicalin	0-8	interleukin 1 beta	Homo sapiens	109-131
30428756-7	2018	Furthermore, co-incubation with Tet significantly down-regulated HaCaT cell production of tumour necrosis factor (TNF)-alpha, IL-1beta, IL-6, IL-20 and chemokine (C-C motif) ligand 20 (CCL20) induced by IL-22.	tet	32-35	interleukin 1 beta	Homo sapiens	126-134
30260294-2	2018	P2X7 receptor activation by adenosine-triphosphate leads to the release of interleukin-1beta.	Adenosine Triphosphate	28-50	interleukin 1 beta	Homo sapiens	75-92
30251185-7	2018	IL-33 in affected fibroblasts was induced by IL-1beta, TNFalpha, or TNFalpha/TGF-beta, while the effect of IL-1beta or TNFalpha/TGF-beta was blocked by curcumin.	Curcumin	152-160	interleukin 1 beta	Homo sapiens	107-115
30260294-11	2018	JNJ-54175446 inhibited lipopolysaccharide/3"-O-(4-benzoylbenzoyl)-ATP-induced interleukin-1beta release from peripheral blood in a dose-dependent manner (inhibitory concentration (IC)50:82 ng/mL; 95% confidence interval: 48-94).	JNJ-54175446	0-12	interleukin 1 beta	Homo sapiens	78-95
30221352-11	2018	Sr2+ reversed LPS-stimulated proinflammatory cytokine expressions such as tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6 and IL-8.	strontium cation	0-4	interleukin 1 beta	Homo sapiens	103-125
30260294-11	2018	JNJ-54175446 inhibited lipopolysaccharide/3"-O-(4-benzoylbenzoyl)-ATP-induced interleukin-1beta release from peripheral blood in a dose-dependent manner (inhibitory concentration (IC)50:82 ng/mL; 95% confidence interval: 48-94).	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	42-69	interleukin 1 beta	Homo sapiens	78-95
29644527-6	2018	To investigate the mechanism of gemcabene-mediated reduction of CRP, transfection studies were performed with human CRP regulatory sequences in luciferase/beta-gal system that showed 25-fold increase in IL-6- and IL-6 plus IL-1beta-stimulated CRP transcription.	gemcabene	32-41	interleukin 1 beta	Homo sapiens	223-231
29644527-4	2018	In human hepatoma cells, gemcabene inhibited IL-6 plus IL-1beta-induced CRP production in a concentration-dependent manner, reaching 70% inhibition at 2 mM.	gemcabene	25-34	interleukin 1 beta	Homo sapiens	55-63
31949688-5	2018	NFkappaB is a key molecule in the downstream signaling pathway of IL-1beta, and the expression of IL-1beta and NFkappaB is positively associated with serum total bilirubin (TBIL).	Bilirubin	162-171	interleukin 1 beta	Homo sapiens	98-106
29644527-10	2018	In conclusion, gemcabene decreases CRP by C/EBP-delta and NF-kappaB-mediated transcriptional mechanism and suppresses IL-6 and IL-1beta-induced CRP production.	gemcabene	15-24	interleukin 1 beta	Homo sapiens	127-135
30365119-0	2018	Andrographolide mitigates IL-1beta-induced human nucleus pulposus cells degeneration through the TLR4/MyD88/NF-kappaB signaling pathway.	andrographolide	0-15	interleukin 1 beta	Homo sapiens	26-34
30320338-0	2018	NF-kappaB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1beta production: Inhibition of the PM2.5-induced inflammation model.	dehydroxymethylepoxyquinomicin	20-25	interleukin 1 beta	Homo sapiens	73-90
30320338-0	2018	NF-kappaB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1beta production: Inhibition of the PM2.5-induced inflammation model.	titanium dioxide	35-51	interleukin 1 beta	Homo sapiens	73-90
30284682-0	2018	Ruthenium pyridyl thiocyanate complex increased the production of pro-inflammatory TNFalpha and IL1beta cytokines by the LPS stimulated mammalian macrophages in vitro.	ruthenium pyridyl thiocyanate	0-29	interleukin 1 beta	Homo sapiens	96-103
30284682-7	2018	Our results support our hypothesis since K330 lead to a significant increase in TNFalpha and IL1beta cytokine production levels by LPS stimulated macrophages compared to only LPS treated control groups.	(3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy) ethyl]azetidin-2-one	41-45	interleukin 1 beta	Homo sapiens	93-100
30320338-5	2018	Among them, Anatase-type TiO2 particles with a primary diameter of 50 nm (A50) were reported to induce interleukin (IL)-1beta production and secretion effectively in phorbol 12-myristate 13-acetate-treated human monocytic leukemia THP-1 cells (THP-1 macrophages).	titanium dioxide	25-29	interleukin 1 beta	Homo sapiens	103-125
30532634-14	2018	We also confirmed that zingerone suppressed the level of redox sensitive transcription factor NFkappaB and downregulated other downstream inflammatory cytokines like interleukins (IL1-beta IL-2, IL-6) and tumor necrosis factor alpha (TNF-alpha).	zingerone	23-32	interleukin 1 beta	Homo sapiens	180-188
30320338-5	2018	Among them, Anatase-type TiO2 particles with a primary diameter of 50 nm (A50) were reported to induce interleukin (IL)-1beta production and secretion effectively in phorbol 12-myristate 13-acetate-treated human monocytic leukemia THP-1 cells (THP-1 macrophages).	Tetradecanoylphorbol Acetate	166-197	interleukin 1 beta	Homo sapiens	103-125
30320338-7	2018	The present study investigated whether the NF-kappaB inhibitor DHMEQ inhibits TiO2 nanoparticle-induced IL-1beta production in THP-1 macrophages, and determined the mechanism.	dehydroxymethylepoxyquinomicin	63-68	interleukin 1 beta	Homo sapiens	104-112
30320338-7	2018	The present study investigated whether the NF-kappaB inhibitor DHMEQ inhibits TiO2 nanoparticle-induced IL-1beta production in THP-1 macrophages, and determined the mechanism.	titanium dioxide	78-82	interleukin 1 beta	Homo sapiens	104-112
30320338-8	2018	As a result, DHMEQ inhibited A50-induced IL-1beta secretion in ELISA assays at nontoxic concentrations.	dehydroxymethylepoxyquinomicin	13-18	interleukin 1 beta	Homo sapiens	41-49
30320338-10	2018	Although NLR family pyrin domain containing 3 (NLRP3)-inflammasome-caspase-1 activation is required for the maturation of IL-1beta, and DHMEQ reduced the NLRP3 mRNA expression and caspase-1 activity; a caspase-1 inhibitor did not influence the A50-induced IL-1beta production.	dehydroxymethylepoxyquinomicin	136-141	interleukin 1 beta	Homo sapiens	122-130
30320338-10	2018	Although NLR family pyrin domain containing 3 (NLRP3)-inflammasome-caspase-1 activation is required for the maturation of IL-1beta, and DHMEQ reduced the NLRP3 mRNA expression and caspase-1 activity; a caspase-1 inhibitor did not influence the A50-induced IL-1beta production.	dehydroxymethylepoxyquinomicin	136-141	interleukin 1 beta	Homo sapiens	256-264
30320338-11	2018	Therefore, it is likely that inhibition of pro-IL-1beta expression by DHMEQ may be sufficient to inhibit mature IL-1beta production.	dehydroxymethylepoxyquinomicin	70-75	interleukin 1 beta	Homo sapiens	43-55
30320338-11	2018	Therefore, it is likely that inhibition of pro-IL-1beta expression by DHMEQ may be sufficient to inhibit mature IL-1beta production.	dehydroxymethylepoxyquinomicin	70-75	interleukin 1 beta	Homo sapiens	47-55
30323145-9	2018	BAPTA-AM pretreatment abolished the H2O2-induced activation of NLRP3 inflammasomes, caspase-1 expression, interleukin-1beta expression and apoptosis in SHSY5Y cells, and had no effect in cells with downregulated STAT3 expression by RNAi.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	0-8	interleukin 1 beta	Homo sapiens	106-123
30323145-9	2018	BAPTA-AM pretreatment abolished the H2O2-induced activation of NLRP3 inflammasomes, caspase-1 expression, interleukin-1beta expression and apoptosis in SHSY5Y cells, and had no effect in cells with downregulated STAT3 expression by RNAi.	Hydrogen Peroxide	36-40	interleukin 1 beta	Homo sapiens	106-123
30513737-0	2018	Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages.	Resveratrol	69-80	interleukin 1 beta	Homo sapiens	105-123
30513737-9	2018	Moreover, this strong reduction of pro-inflammatory IL-1beta is associated with a decrease of NLRP3 and, in J774A, ASC protein expression, which depends on the choice of activator ATP or nigericin.	Adenosine Triphosphate	180-183	interleukin 1 beta	Homo sapiens	52-60
30513737-9	2018	Moreover, this strong reduction of pro-inflammatory IL-1beta is associated with a decrease of NLRP3 and, in J774A, ASC protein expression, which depends on the choice of activator ATP or nigericin.	Nigericin	187-196	interleukin 1 beta	Homo sapiens	52-60
30415294-7	2018	Cell culture in 0.2% O2 induced expression of NLRP3 and pro-IL-1beta genes but not of the pro-IL-18 gene.	Oxygen	21-23	interleukin 1 beta	Homo sapiens	56-68
30439604-7	2018	Additionally, HG-elevated high transcripts and secretions of pro-inflammatory cytokines were reversed following celastrol treatment, including IL-1beta, TNF-alpha, IL-6.	celastrol	112-121	interleukin 1 beta	Homo sapiens	143-151
30505285-8	2018	In a model using virus mimicking synthetic double-stranded RNA, infection causes sequential signaling such as increased blood brain barrier (BBB) permeability, microglia/macrophage activation through Toll-like receptor 3 (TLR3) signaling, secretion of IL-1beta, upregulation of the serotonin transporter (5-HTT) in astrocytes, reducing extracellular serotonin (5-HT) levels and hence reduced activation of 5-HT1A receptor subtype.	Serotonin	282-291	interleukin 1 beta	Homo sapiens	252-260
30144574-0	2018	Immunostimulatory effect of Zinc Phthalocyanine derivatives on macrophages based on the pro-inflammatory TNFalpha and IL1beta cytokine production levels.	Zn(II)-phthalocyanine	28-47	interleukin 1 beta	Homo sapiens	118-125
30144574-6	2018	Our results suggest an immunostimulatory role for the iodine substituted ZnPc on macrophages based on the changes in pro-inflammatory cytokine production levels (TNFalpha, IL1beta and IL6).	Iodine	54-60	interleukin 1 beta	Homo sapiens	172-179
30144574-6	2018	Our results suggest an immunostimulatory role for the iodine substituted ZnPc on macrophages based on the changes in pro-inflammatory cytokine production levels (TNFalpha, IL1beta and IL6).	zinc(II) phthalocyanine trisulfonic acid	73-77	interleukin 1 beta	Homo sapiens	172-179
30555323-11	2018	In LPS-primed THP-1 cells stimulated by nigericin (a model to study the NLRP3 inflammasome), rifaximin reduced IL-1beta production in a concentration-dependent fashion, this effect being associated with inhibition of the up-stream caspase-1 activation.	Nigericin	40-49	interleukin 1 beta	Homo sapiens	111-119
30555323-11	2018	In LPS-primed THP-1 cells stimulated by nigericin (a model to study the NLRP3 inflammasome), rifaximin reduced IL-1beta production in a concentration-dependent fashion, this effect being associated with inhibition of the up-stream caspase-1 activation.	Rifaximin	93-102	interleukin 1 beta	Homo sapiens	111-119
30519189-7	2018	Anti-inflammatory actions of Cana in IL-1beta-treated HUVEC and of Dapa in LPS-treated cardiofibroblast were mediated by AMPK activation.	Canagliflozin	29-33	interleukin 1 beta	Homo sapiens	37-45
30515094-19	2018	Ultimately paeonol decreased the expression of IL-1beta, IL-6, ICAM-1, VCAM-1 in HUVECs and alleviated adhesion of THP-1 cells to HUVECs.	paeonol	11-18	interleukin 1 beta	Homo sapiens	47-55
30450301-9	2018	Moreover, ligation of GPR91 with succinate promoted the lipopolysaccharide-induced production of NLRP3, IL-1beta, VEGF and MMP-13 in PBMCs through increased phosphorylation of p65.	Succinic Acid	33-42	interleukin 1 beta	Homo sapiens	104-112
30205151-4	2018	In addition, exposure to acrolein resulted in NLRP3 inflammasome activation as evidenced by cleavage of caspase-1 and downstream mature interleukin (IL)-1beta and IL-18 secretion.	Acrolein	25-33	interleukin 1 beta	Homo sapiens	136-158
30486377-0	2018	Pterostilbene Attenuates Hexavalent Chromium-Induced Allergic Contact Dermatitis by Preventing Cell Apoptosis and Inhibiting IL-1beta-Related NLRP3 Inflammasome Activation.	pterostilbene	0-13	interleukin 1 beta	Homo sapiens	125-133
30486377-0	2018	Pterostilbene Attenuates Hexavalent Chromium-Induced Allergic Contact Dermatitis by Preventing Cell Apoptosis and Inhibiting IL-1beta-Related NLRP3 Inflammasome Activation.	Chromium	36-44	interleukin 1 beta	Homo sapiens	125-133
30595799-0	2018	Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes.	Tryptophan	0-10	interleukin 1 beta	Homo sapiens	47-51
30515160-0	2018	Betaine Inhibits Interleukin-1beta Production and Release: Potential Mechanisms.	Betaine	0-7	interleukin 1 beta	Homo sapiens	17-34
30515160-1	2018	Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1beta secretion; however, the underlying mechanisms by which betaine inhibits IL-1beta secretion remain to be uncovered.	Betaine	0-7	interleukin 1 beta	Homo sapiens	107-129
30515160-1	2018	Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1beta secretion; however, the underlying mechanisms by which betaine inhibits IL-1beta secretion remain to be uncovered.	Betaine	0-7	interleukin 1 beta	Homo sapiens	202-210
30515160-1	2018	Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1beta secretion; however, the underlying mechanisms by which betaine inhibits IL-1beta secretion remain to be uncovered.	Betaine	185-192	interleukin 1 beta	Homo sapiens	202-210
30515160-2	2018	In this review, we summarize the current understanding about the mechanisms of betaine in IL-1beta production and release.	Betaine	79-86	interleukin 1 beta	Homo sapiens	90-98
30483128-7	2018	In addition, taxifolin alleviated ovariectomized-induced bone loss by repressing osteoclast activity and decreasing serum levels of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and receptor activator of nuclear factor-kappaB ligand (RANKL) in vivo.	taxifolin	13-22	interleukin 1 beta	Homo sapiens	161-178
30515160-3	2018	For IL-1beta production, betaine affects canonical and non-canonical inflammasome-mediated processing of IL-1beta through signaling pathways, such as NF-kappaB, NLRP3 and caspase-8/11.	Betaine	25-32	interleukin 1 beta	Homo sapiens	4-12
30515160-3	2018	For IL-1beta production, betaine affects canonical and non-canonical inflammasome-mediated processing of IL-1beta through signaling pathways, such as NF-kappaB, NLRP3 and caspase-8/11.	Betaine	25-32	interleukin 1 beta	Homo sapiens	105-113
30515160-5	2018	Collectively, this review highlights the anti-inflammatory property of betaine by inhibiting the production and release of IL-1beta, and indicates the potential application of betaine supplementation as an adjuvant therapy in various inflammatory diseases associating with IL-1beta secretion.	Betaine	71-78	interleukin 1 beta	Homo sapiens	123-131
30515160-5	2018	Collectively, this review highlights the anti-inflammatory property of betaine by inhibiting the production and release of IL-1beta, and indicates the potential application of betaine supplementation as an adjuvant therapy in various inflammatory diseases associating with IL-1beta secretion.	Betaine	71-78	interleukin 1 beta	Homo sapiens	273-281
30515160-5	2018	Collectively, this review highlights the anti-inflammatory property of betaine by inhibiting the production and release of IL-1beta, and indicates the potential application of betaine supplementation as an adjuvant therapy in various inflammatory diseases associating with IL-1beta secretion.	Betaine	176-183	interleukin 1 beta	Homo sapiens	273-281
30092543-4	2018	PM2.5 was found capable of causing weak cell death but potent IL-1beta secretion in THP-1 cells, which was involved in NLRP3 inflammasome activation as evidenced by Z-YVAD-FMK inhibited IL-1beta secretion and overexpressed ASC and NLRP3 protein in PM2.5 treated cells.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	165-175	interleukin 1 beta	Homo sapiens	62-70
30092543-4	2018	PM2.5 was found capable of causing weak cell death but potent IL-1beta secretion in THP-1 cells, which was involved in NLRP3 inflammasome activation as evidenced by Z-YVAD-FMK inhibited IL-1beta secretion and overexpressed ASC and NLRP3 protein in PM2.5 treated cells.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	165-175	interleukin 1 beta	Homo sapiens	186-194
30429487-6	2018	In addition, a single intra-discal injection of NTG-101 into the injured IVD-NPs resulted in sustained expression of healthy extra-cellular matrix (ECM) proteins (aggrecan, collagen 2A1) and reduced expression of inflammation associated proteins and molecules (IL-1beta, IL-6, IL-8, MMP-13, Cox-2 and PGE2) as compared to vehicle controls.	ntg-101	48-55	interleukin 1 beta	Homo sapiens	261-269
30422993-10	2018	These results demonstrated that combined treatment with sirolimus and oseltamivir attenuates pH1N1-induced severe lung injury, which is correlated with suppressed mTOR-NLRP3-IL-1beta axis and reduced viral titer.	Sirolimus	56-65	interleukin 1 beta	Homo sapiens	174-182
30422993-10	2018	These results demonstrated that combined treatment with sirolimus and oseltamivir attenuates pH1N1-induced severe lung injury, which is correlated with suppressed mTOR-NLRP3-IL-1beta axis and reduced viral titer.	Oseltamivir	70-81	interleukin 1 beta	Homo sapiens	174-182
30265541-8	2018	As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10.	ursolic acid	74-76	interleukin 1 beta	Homo sapiens	217-225
30401897-4	2018	This study describes the effects of Palm Fruit Bioactives (PFB) on the behavior of human astrocytes which have been activated by IL-1beta.	palm fruit	36-46	interleukin 1 beta	Homo sapiens	129-137
30401897-4	2018	This study describes the effects of Palm Fruit Bioactives (PFB) on the behavior of human astrocytes which have been activated by IL-1beta.	2,3,4,5,6-Pentafluorobenzyl alcohol	59-62	interleukin 1 beta	Homo sapiens	129-137
30401897-7	2018	We show significant inhibition of these pro-inflammatory processes when IL-1beta-activated astrocytes are exposed to PFB.	2,3,4,5,6-Pentafluorobenzyl alcohol	117-120	interleukin 1 beta	Homo sapiens	72-80
30401897-9	2018	We also show that PFB significantly reduces ROS production by IL-1beta-activated astrocytes.	2,3,4,5,6-Pentafluorobenzyl alcohol	18-21	interleukin 1 beta	Homo sapiens	62-70
30401897-9	2018	We also show that PFB significantly reduces ROS production by IL-1beta-activated astrocytes.	Reactive Oxygen Species	44-47	interleukin 1 beta	Homo sapiens	62-70
30292895-9	2018	Although the formation of foam cells in the presence of oxidized-LDL (oxLDL) remained unaffected, the molecules containing the dimethylamino moiety were able to decrease the expression of IL-1beta in LPS/INF-gamma challenged macrophages.	Dimethyl amidogen	127-140	interleukin 1 beta	Homo sapiens	188-196
30099341-3	2018	LPS plus ATP initiated IL-1beta cleavage and release in mouse peritoneal macrophages and peaked at 4 h. Leucodin did not show significant toxicity within 200 muM and effectively inhibited pro-IL-1beta cleavage and release of mature-IL-1beta in macrophages.	Adenosine Triphosphate	9-12	interleukin 1 beta	Homo sapiens	188-200
30488711-5	2018	The presence of the aluminium-based adjuvant interfered with the MAT, increasing the readout of IL-1beta in LPS-spiked MenCC batches.	aluminium-based adjuvant	20-44	interleukin 1 beta	Homo sapiens	96-104
30099341-3	2018	LPS plus ATP initiated IL-1beta cleavage and release in mouse peritoneal macrophages and peaked at 4 h. Leucodin did not show significant toxicity within 200 muM and effectively inhibited pro-IL-1beta cleavage and release of mature-IL-1beta in macrophages.	Adenosine Triphosphate	9-12	interleukin 1 beta	Homo sapiens	192-200
30257325-0	2018	Eriodictyol inhibits IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes.	eriodictyol	0-11	interleukin 1 beta	Homo sapiens	21-29
30257325-4	2018	Our results showed that eriodictyol attenuated the inhibition of cell viability in IL-1beta-stimulated chondrocytes.	eriodictyol	24-35	interleukin 1 beta	Homo sapiens	83-91
30257325-5	2018	In addition, eriodictyol inhibited the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and the production of prostaglandin E2 (PGE2) and nitric oxide (NO), which were induced by IL-1beta.	eriodictyol	13-24	interleukin 1 beta	Homo sapiens	214-222
30257325-6	2018	The induction of inflammatory cytokines and matrix metalloproteinases (MMPs) caused by IL-1beta stimulation was also attenuated by eriodictyol.	eriodictyol	131-142	interleukin 1 beta	Homo sapiens	87-95
30257325-7	2018	Furthermore, eriodictyol pretreatment inhibited IkappaBalpha degradation and the level of p-p65, and enhanced the up-regulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase 1 (HO-1) in IL-1beta-stimulated chondrocytes.	eriodictyol	13-24	interleukin 1 beta	Homo sapiens	213-221
30257325-10	2018	These findings indicated that eriodictyol exhibited anti-inflammatory effect in IL-1beta-stimulated chondrocytes.	eriodictyol	30-41	interleukin 1 beta	Homo sapiens	80-88
30464073-4	2018	To elucidate the action mechanism of resveratrol, effect of resveratrol on IL-1beta-induced NF-kappaB signaling pathway was investigated in SW1353, a human chondrosarcoma cell line, by western blot analysis.	Resveratrol	60-71	interleukin 1 beta	Homo sapiens	75-83
30218403-4	2018	Our results indicated that administration of BHB suppressed C6 cells migration and NLRP3 inflammasome activation, reducing the levels of activated cysteinyl aspartate-specific proteinase 1 (caspase-1) and mature Interleukin 1beta (IL-1beta).	3-Hydroxybutyric Acid	45-48	interleukin 1 beta	Homo sapiens	212-229
30193876-12	2018	Treatment with miR-125b mimic markedly decreased the protein levels of TP53INP1, p53 and cytokines interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha, whereas miR-125b control or inhibitor did not have the above-mentioned effects.	mir-125b	15-23	interleukin 1 beta	Homo sapiens	99-121
30076967-5	2018	Activation of P2YRs with adenosine tri-phosphate (ATP) resulted in a time- and concentration-dependent inhibition of IL-1beta-mediated phosphorylation of JNK and associated kinase activity.	Adenosine Triphosphate	25-48	interleukin 1 beta	Homo sapiens	117-125
30076967-5	2018	Activation of P2YRs with adenosine tri-phosphate (ATP) resulted in a time- and concentration-dependent inhibition of IL-1beta-mediated phosphorylation of JNK and associated kinase activity.	Adenosine Triphosphate	50-53	interleukin 1 beta	Homo sapiens	117-125
30076967-8	2018	The novel Galphaq/11 inhibitor YM254890 and a protein kinase A (PKA) inhibitor H89 both partially reversed ATP-mediated inhibition of IL-1beta-stimulated JNK indicating involvement of both Galphaq/11 and Galphas mediated pathways.	galphaq/11	10-20	interleukin 1 beta	Homo sapiens	134-142
30076967-8	2018	The novel Galphaq/11 inhibitor YM254890 and a protein kinase A (PKA) inhibitor H89 both partially reversed ATP-mediated inhibition of IL-1beta-stimulated JNK indicating involvement of both Galphaq/11 and Galphas mediated pathways.	YM-254890	31-39	interleukin 1 beta	Homo sapiens	134-142
30076967-8	2018	The novel Galphaq/11 inhibitor YM254890 and a protein kinase A (PKA) inhibitor H89 both partially reversed ATP-mediated inhibition of IL-1beta-stimulated JNK indicating involvement of both Galphaq/11 and Galphas mediated pathways.	Adenosine Triphosphate	107-110	interleukin 1 beta	Homo sapiens	134-142
30218403-4	2018	Our results indicated that administration of BHB suppressed C6 cells migration and NLRP3 inflammasome activation, reducing the levels of activated cysteinyl aspartate-specific proteinase 1 (caspase-1) and mature Interleukin 1beta (IL-1beta).	3-Hydroxybutyric Acid	45-48	interleukin 1 beta	Homo sapiens	231-239
30076967-8	2018	The novel Galphaq/11 inhibitor YM254890 and a protein kinase A (PKA) inhibitor H89 both partially reversed ATP-mediated inhibition of IL-1beta-stimulated JNK indicating involvement of both Galphaq/11 and Galphas mediated pathways.	galphaq/11	189-199	interleukin 1 beta	Homo sapiens	134-142
30218403-6	2018	BHB also counteracted the LPS/ATP-promoted cell migration by suppressing the activation of caspase-1 and the maturation of IL-1beta.	3-Hydroxybutyric Acid	0-3	interleukin 1 beta	Homo sapiens	123-131
30076967-8	2018	The novel Galphaq/11 inhibitor YM254890 and a protein kinase A (PKA) inhibitor H89 both partially reversed ATP-mediated inhibition of IL-1beta-stimulated JNK indicating involvement of both Galphaq/11 and Galphas mediated pathways.	galphas	204-211	interleukin 1 beta	Homo sapiens	134-142
30218403-6	2018	BHB also counteracted the LPS/ATP-promoted cell migration by suppressing the activation of caspase-1 and the maturation of IL-1beta.	Adenosine Triphosphate	30-33	interleukin 1 beta	Homo sapiens	123-131
30076967-9	2018	ATP also partially reversed IL-1beta-mediated induction of cyclo-oxygenase-2 (COX-2) and E-selectin.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	28-36
29457525-9	2018	The expression levels of Bax, caspase-3, and caspase-9 in AFCs decreased significantly in the IL-1beta+U0126 group compared with those in the IL-1beta group.	U 0126	103-108	interleukin 1 beta	Homo sapiens	94-102
30041151-7	2018	Macrophages grown on Mg-containing surface were switched from M1 to M2 phenotype with the stimulation of LPS, evidenced by suppressed gene expressions of M1 markers (CD86, CD11c and iNOS) and pro-inflammatory cytokines (TNF-alpha and IL-1beta), promoted gene expression of M2 marker CD163 and decreased TNF-alpha release.	Magnesium	21-23	interleukin 1 beta	Homo sapiens	234-242
30138619-9	2018	Treatment of cultured PBMCs with 10 ng of lipopolysaccharide induced NLRP3, caspase-1, ASC, IL-1beta, IL-17A, and IL-23 expression, which was marked suppressed by treatment with ascorbic acid.	Ascorbic Acid	178-191	interleukin 1 beta	Homo sapiens	92-100
30269025-8	2018	Reporter assays for hepcidin transcription revealed that reporters with mutations of cAMP response element (CRE) site B, a putative Jun binding element, decreased responsiveness to IL-1beta, and that activated JunB, but not c-Jun, conferred IL-1beta-induced hepcidin transcription.	Cyclic AMP	85-89	interleukin 1 beta	Homo sapiens	181-189
30114628-9	2018	In summary, increased maternal glucose levels during pregnancy changed systemic and placental inflammatory patterns, which occurred in parallel with the expression of inflammasome factors and processing and secretion of the pro-inflammatory cytokine IL-1beta.	Glucose	31-38	interleukin 1 beta	Homo sapiens	250-258
30269025-7	2018	SP600125, a JNK inhibitor, blocked IL-1beta-induced phosphorylation of c-Jun and JunB as well as IL-1beta-induced expression and transcription of hepcidin.	pyrazolanthrone	0-8	interleukin 1 beta	Homo sapiens	35-43
30269025-7	2018	SP600125, a JNK inhibitor, blocked IL-1beta-induced phosphorylation of c-Jun and JunB as well as IL-1beta-induced expression and transcription of hepcidin.	pyrazolanthrone	0-8	interleukin 1 beta	Homo sapiens	97-105
30269025-8	2018	Reporter assays for hepcidin transcription revealed that reporters with mutations of cAMP response element (CRE) site B, a putative Jun binding element, decreased responsiveness to IL-1beta, and that activated JunB, but not c-Jun, conferred IL-1beta-induced hepcidin transcription.	Cyclic AMP	85-89	interleukin 1 beta	Homo sapiens	241-249
30348823-3	2018	When human islets were exposed to inflammatory stress induced by interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma, arginine residue R510 within GRP78 was converted into citrulline, as evidenced by liquid chromatography-tandem mass spectrometry.	Citrulline	189-199	interleukin 1 beta	Homo sapiens	65-111
30073768-5	2018	In this framework, we hypothesize that, through their unique mechanism of action and by increasing circulating ketone bodies, SGLT2 inhibitors indirectly target the IL-1beta pathway and thus produce a consistent amelioration of low-grade inflammation, a clinically relevant phenomenon in diabetic patients with high CV risk.	Ketones	111-117	interleukin 1 beta	Homo sapiens	165-173
30344669-3	2018	Downregulation of miR-140-5p increased the levels of inflammatory factors induced by ALI [including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and myeloperoxidase] in an in vitro model of human lung A549 cells.	mir-140-5p	18-28	interleukin 1 beta	Homo sapiens	129-151
29796776-11	2018	Lastly, we observed that DHA not only reduced the PGE2 levels in tumor necrosis factor-alpha (TNF-alpha)-treated ECs but also blunted the upregulation of inflammatory cytokines of interleukin (IL)-6 and IL-1beta induced by TNF-alpha or PGE2.	artenimol	25-28	interleukin 1 beta	Homo sapiens	203-211
30172103-5	2018	The results showed that treatment of abietic acid significantly inhibited IL-1beta-induced TNF-alpha, NO, PGE2 production, and COX-2 expression.	abietic acid	37-49	interleukin 1 beta	Homo sapiens	74-82
30153531-6	2018	Our results demonstrated the anti-inflammatory effect of the novel synthesized VA692, and confirmed those of celecoxib, in counteracting the stimulus of IL-1beta in both osteoarthritic (OA) chondrocytes and T/C-28a2 cell line.	va692	79-84	interleukin 1 beta	Homo sapiens	153-161
30145470-7	2018	As the result, 4MC pre-treatment decreased kidney damage, ROS production, the renal levels of TGFbeta1, CD68, tumor necrosis factor-alpha and interleukin 1beta.	4-methylcatechol	15-18	interleukin 1 beta	Homo sapiens	142-159
30172103-0	2018	Abietic acid attenuates IL-1beta-induced inflammation in human osteoarthritis chondrocytes.	abietic acid	0-12	interleukin 1 beta	Homo sapiens	24-32
30172103-5	2018	The results showed that treatment of abietic acid significantly inhibited IL-1beta-induced TNF-alpha, NO, PGE2 production, and COX-2 expression.	Dinoprostone	106-110	interleukin 1 beta	Homo sapiens	74-82
30172103-6	2018	Abietic acid also concentration-dependently suppressed MMP1, MMP3, and MMP13 production induced by IL-1beta.	abietic acid	0-12	interleukin 1 beta	Homo sapiens	99-107
30205322-0	2018	Isofraxidin inhibits interleukin-1beta induced inflammatory response in human osteoarthritis chondrocytes.	isofraxidin	0-11	interleukin 1 beta	Homo sapiens	21-38
30205322-5	2018	The results showed that IF blocked IL-1beta-stimulated production of NO and PGE2.	Dinoprostone	76-80	interleukin 1 beta	Homo sapiens	35-43
30172103-10	2018	In conclusion, the study elucidated abietic acid suppressed IL-1beta-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-gamma.	abietic acid	36-48	interleukin 1 beta	Homo sapiens	60-68
29105345-7	2018	RESULTS: Our results demonstrated that treatment with LPS and ATP increased significantly both in mRNA and protein levels of all the NLRP3 inflammasome components, and triggered the NLRP3 inflammasome, followed by upregulated IL-1beta and IL-18 in the cell supernatant.	Adenosine Triphosphate	62-65	interleukin 1 beta	Homo sapiens	226-234
30261465-6	2018	Levels of IL-1beta-induced inflammatory biomarkers including TNF-alpha, COX-2, IL-6 and iNOS were reduced by Co-Q10, which was possibly associated with inhibition of NF-kappaB signaling activation.	coenzyme Q10	109-115	interleukin 1 beta	Homo sapiens	10-18
30261465-7	2018	Furthermore, Co-Q10 maintained the production of anabolic biomarkers in NP cells such as collagen 2, aggrecan and Sox-9 and altered the enhanced catabolism induced by IL-1beta.	coenzyme Q10	13-19	interleukin 1 beta	Homo sapiens	167-175
30261465-0	2018	Potential therapeutic role of Co-Q10 in alleviating intervertebral disc degeneration and suppressing IL-1beta-mediated inflammatory reaction in NP cells.	coenzyme Q10	30-36	interleukin 1 beta	Homo sapiens	101-109
30076630-4	2018	Our results demonstrated that pretreatment with PF effectively attenuated PMACI-induced production of tumor necrosis factor-alpha and interleukin 1beta in HMC-1 cells.	peoniflorin	48-50	interleukin 1 beta	Homo sapiens	134-151
30226596-9	2018	However, the increased caspase-1 activities and IL-1beta secretion levels induced in response to treatment with TNF-alpha or ATP were significantly reduced by P2Y2R knockdown or the presence of apyrase in both the MDA-MB-231 and RT-R-MDA-MB-231 cells, suggesting the involvement of ATP-activated P2Y2R in inflammasome activation.	Adenosine Triphosphate	125-128	interleukin 1 beta	Homo sapiens	48-56
29764192-3	2018	Here, we investigated the effects of simvastatin treatment on expression levels of interleukin (IL) 1beta in both patient with hyperlipidemia and healthy human peripheral blood mononuclear cells (PBMCs) using cholesterol crystals (CC), a cardiovascular pathogenic stimulus for activation of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome.	Simvastatin	37-48	interleukin 1 beta	Homo sapiens	83-105
29764192-4	2018	Cholesterol crystal-induced NLRP3 inflammasome activation was used to trigger maturation and release of IL-1beta in PBMCs.	Cholesterol	0-11	interleukin 1 beta	Homo sapiens	104-112
29764192-7	2018	The effects of simvastatin treatment on levels of IL-1beta expression were determined by enzyme-linked immunosorbent assay and western blot.	Simvastatin	15-26	interleukin 1 beta	Homo sapiens	50-58
29764192-8	2018	Both in vitro and in vivo treatments with simvastatin led to a significant reduction in the levels of expression of IL-1beta in response to stimulation with CC.	Simvastatin	42-53	interleukin 1 beta	Homo sapiens	116-124
29764192-9	2018	Simvastatin inhibits the expression and activation of IL-1beta induced by CC in PBMCs, which may contribute to its protective role in patients with cardiovascular disease.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	54-62
29749036-6	2018	Moreover, mRNA expression levels of IL-1beta, TNFalpha, TLR1, and TLR2 in the SDH were positively correlated with plasma glucose concentrations in all monkeys.	sdh	78-81	interleukin 1 beta	Homo sapiens	36-44
29749036-6	2018	Moreover, mRNA expression levels of IL-1beta, TNFalpha, TLR1, and TLR2 in the SDH were positively correlated with plasma glucose concentrations in all monkeys.	Glucose	121-128	interleukin 1 beta	Homo sapiens	36-44
29932233-10	2018	LY294002 also reversed the elevated SOX2 and NANOG expression induced by IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Homo sapiens	73-81
30076630-4	2018	Our results demonstrated that pretreatment with PF effectively attenuated PMACI-induced production of tumor necrosis factor-alpha and interleukin 1beta in HMC-1 cells.	pmaci	74-79	interleukin 1 beta	Homo sapiens	134-151
30287519-10	2018	Thus, SDA and DHA may attenuate macrophage-derived TNF-alpha inducing CTSS and inflammasome activation, IL-1beta secretion, and placental trophoblast cell death.	stearidonic acid	6-9	interleukin 1 beta	Homo sapiens	104-112
30316188-8	2018	MiR-199a promoted LPS-induced NF-kappaB activation and improved the secretion of TNF-alpha and IL-1beta by regulation of Klotho in HEK293 T cells.	mir-199a	0-8	interleukin 1 beta	Homo sapiens	95-103
30316188-9	2018	If miR-199a antagomir was administrated after 48 h of pristane administration, the expression of p-P65 and the secretion of TNF-alpha and IL-1beta were significantly down-regulated in LN kidney.	mir-199a	3-11	interleukin 1 beta	Homo sapiens	138-146
30316188-9	2018	If miR-199a antagomir was administrated after 48 h of pristane administration, the expression of p-P65 and the secretion of TNF-alpha and IL-1beta were significantly down-regulated in LN kidney.	pristane	54-62	interleukin 1 beta	Homo sapiens	138-146
30287519-10	2018	Thus, SDA and DHA may attenuate macrophage-derived TNF-alpha inducing CTSS and inflammasome activation, IL-1beta secretion, and placental trophoblast cell death.	Docosahexaenoic Acids	14-17	interleukin 1 beta	Homo sapiens	104-112
30416448-10	2018	In addition, resistin increased the mRNA expressions of proinflammatory cytokines tumor nuclear factor (TNF)alpha and interleukin (IL)-1beta, which were also prevented by TUDCA.	ursodoxicoltaurine	171-176	interleukin 1 beta	Homo sapiens	118-140
30380653-0	2018	Inhibition of Osteoarthritis-Related Molecules by Isomucronulatol 7-O-beta-d-glucoside and Ecliptasaponin A in IL-1beta-Stimulated Chondrosarcoma Cell Model.	ecliptasaponin A	91-107	interleukin 1 beta	Homo sapiens	111-119
30359318-9	2018	Following pretreatment with protein synthesis inhibitor cycloheximide, we found that IL-1beta induced CXCR3 on the surface of MSCs via protein synthesis pathway.	Cycloheximide	56-69	interleukin 1 beta	Homo sapiens	85-93
30355448-7	2018	Upon exposure to IL-1beta, INAVA relocates to form cytosolic puncta, where CUPID amplifies TRAF6-dependent polyubiquitination and inflammatory signaling.	cupid	75-80	interleukin 1 beta	Homo sapiens	17-25
30242335-0	2018	Relationship of Interleukin-1beta Blockade With Incident Gout and Serum Uric Acid Levels: Exploratory Analysis of a Randomized Controlled Trial.	Uric Acid	72-81	interleukin 1 beta	Homo sapiens	16-33
29894789-3	2018	The combined supplementation with allopurinol and l-arginine increased catalase, SOD, GSH, and Gpx, while it decreased lipid peroxidation, IL-6, IL-1beta, and TNF-alpha.	Allopurinol	34-45	interleukin 1 beta	Homo sapiens	145-153
29894789-4	2018	While TNF-alpha, IL-6, IL-1beta, and NF-kappaB mRNA and protein expression were higher in control HOb-OA cells, the combined supplementation with allopurinol and l-arginine substantially reduced their expression in HOb-OA cells by &gt;40%.	Allopurinol	146-157	interleukin 1 beta	Homo sapiens	23-31
29894789-4	2018	While TNF-alpha, IL-6, IL-1beta, and NF-kappaB mRNA and protein expression were higher in control HOb-OA cells, the combined supplementation with allopurinol and l-arginine substantially reduced their expression in HOb-OA cells by &gt;40%.	Arginine	162-172	interleukin 1 beta	Homo sapiens	23-31
30301855-9	2018	Because NLRP3-dependent production of IL-1beta and nitric oxide (NO) in Toxoplasma-infected human cells is involved in the GRA15-dependent virulence mechanism, blocking NO or IL-1beta production in the host could represent a novel therapeutic approach for treating human toxoplasmosis.	Nitric Oxide	51-63	interleukin 1 beta	Homo sapiens	175-183
30402038-7	2018	Lonafarnib significantly suppressed LPS-, IL-1beta-, or TNF-alpha-induced IL-6, IL-8, MCP-1, and GRO-alpha expression and secretion in placental tissue.	lonafarnib	0-10	interleukin 1 beta	Homo sapiens	42-50
30356764-1	2018	Background: Calcium pyrophosphate (CPP) microcrystal deposition is associated with wide clinical phenotypes, including acute and chronic arthritis, that are interleukin 1beta (IL-1beta)-driven.	Calcium Pyrophosphate	12-33	interleukin 1 beta	Homo sapiens	157-174
30356764-1	2018	Background: Calcium pyrophosphate (CPP) microcrystal deposition is associated with wide clinical phenotypes, including acute and chronic arthritis, that are interleukin 1beta (IL-1beta)-driven.	Calcium Pyrophosphate	12-33	interleukin 1 beta	Homo sapiens	176-184
30356764-10	2018	Results: In vitro, IL-1beta production induced by m- and t-CPPD and m-CPPTbeta crystals was NLRP3 inflammasome dependent.	m-cpptbeta	68-78	interleukin 1 beta	Homo sapiens	19-27
30333797-9	2018	CPA patients did not differ significantly in the BALF cytokine profile compared to patients with respiratory disorders without CPA, but showed significant higher values for IFN-gamma, IL-1b, IL-6, IL-8, and TNF-alpha compared to healthy individuals.	cpa	0-3	interleukin 1 beta	Homo sapiens	184-189
31203923-8	2018	Pam2CSK4 increased interleukin-1beta (IL-1beta) secretion by peripheral blood mononuclear cells (PBMCs) of healthy donors, and this activation was inhibited by colchicine.	Colchicine	160-170	interleukin 1 beta	Homo sapiens	19-36
30279441-6	2018	Moreover, H2S reduced mRNA expression of macrophage inflammatory protein-2 (MIP-2) and its receptor in lung tissue, as well as the accumulation of MIP-2 and interleukin-1beta in the alveolar space.	Hydrogen Sulfide	10-13	interleukin 1 beta	Homo sapiens	157-174
30194878-9	2018	RESULTS: Compared to excess glucose alone, combination excess glucose and low-dose aPL (a) further augmented trophoblast inflammatory IL-1beta, inflammasome-associated uric acid and caspase-1, and pro-angiogenic PlGF; (b) dampened trophoblast inflammatory IL-8, anti-angiogenic sEndoglin, and sFlt-1; and (c) further reduced trophoblast migration.	Glucose	62-69	interleukin 1 beta	Homo sapiens	134-142
30232261-0	2018	Substance P and IL-33 administered together stimulate a marked secretion of IL-1beta from human mast cells, inhibited by methoxyluteolin.	methoxyluteolin	121-136	interleukin 1 beta	Homo sapiens	76-84
30232261-3	2018	Preincubation of LAD2 (30 min) with the SP receptor (NK-1) antagonists L-733,060 (10 muM) or CP-96345 (10 microM) inhibits (P &lt; 0.001) secretion of IL-1beta stimulated by either SP (1 muM) or SP together with IL-33 (30 ng/mL).	CP 96345	93-101	interleukin 1 beta	Homo sapiens	151-159
30232261-9	2018	Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P &lt; 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta.	Flavonoids	45-54	interleukin 1 beta	Homo sapiens	140-148
30232261-9	2018	Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P &lt; 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta.	Flavonoids	45-54	interleukin 1 beta	Homo sapiens	168-180
30232261-9	2018	Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P &lt; 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta.	methoxyluteolin	55-70	interleukin 1 beta	Homo sapiens	140-148
30232261-9	2018	Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P &lt; 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta.	methoxyluteolin	55-70	interleukin 1 beta	Homo sapiens	168-180
29945920-12	2018	Single doses of iberdomide (0.3-6 mg) in healthy volunteers decreased intracellular Aiolos (minimum mean per cent of baseline:  12%-28% (B cells);  0%-33% (T cells)), decreased absolute CD19+ B cells, increased IL-2 and decreased IL-1beta production ex vivo.	iberdomide	16-26	interleukin 1 beta	Homo sapiens	230-238
31203923-8	2018	Pam2CSK4 increased interleukin-1beta (IL-1beta) secretion by peripheral blood mononuclear cells (PBMCs) of healthy donors, and this activation was inhibited by colchicine.	Colchicine	160-170	interleukin 1 beta	Homo sapiens	38-46
30075289-3	2018	Within the DH, expression of the pro-inflammatory cytokine interleukin-1beta (IL-1beta) is required for heroin-conditioned peripheral immunomodulation to occur.	Heroin	104-110	interleukin 1 beta	Homo sapiens	59-76
30119184-0	2018	Scoparone prevents IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes through the PI3K/Akt/NF-kappaB pathway.	scoparone	0-9	interleukin 1 beta	Homo sapiens	19-27
30119184-5	2018	Our results showed that IL-1beta treatment significantly inhibited the cell viability of chondrocytes, whereas the inhibition effect was attenuated by scoparone in a dose-dependent manner.	scoparone	151-160	interleukin 1 beta	Homo sapiens	24-32
30119184-6	2018	IL-1beta also efficiently induced the production of nitric oxide (NO), prostaglandin E2 (PGE2), MMP-3, MMP-13, ADAMTS-4 and ADAMTS-5 in chondrocytes.	Nitric Oxide	52-64	interleukin 1 beta	Homo sapiens	0-8
30119184-6	2018	IL-1beta also efficiently induced the production of nitric oxide (NO), prostaglandin E2 (PGE2), MMP-3, MMP-13, ADAMTS-4 and ADAMTS-5 in chondrocytes.	Dinoprostone	71-87	interleukin 1 beta	Homo sapiens	0-8
30119184-6	2018	IL-1beta also efficiently induced the production of nitric oxide (NO), prostaglandin E2 (PGE2), MMP-3, MMP-13, ADAMTS-4 and ADAMTS-5 in chondrocytes.	Dinoprostone	89-93	interleukin 1 beta	Homo sapiens	0-8
30119184-8	2018	In addition, scoparone repressed IL-1beta-induced the expression of iNOS and COX-2 in chondrocytes.	scoparone	13-22	interleukin 1 beta	Homo sapiens	33-41
30119184-9	2018	Furthermore, the activation of the PI3K/Akt/NF-kappaB pathway induced by IL-1beta was diminished by scoparone treatment.	scoparone	100-109	interleukin 1 beta	Homo sapiens	73-81
30119184-10	2018	Taken together, these findings indicated that scoparone inhibited the expression of inflammatory mediators in IL-1beta-induced chondrocytes via regulating the PI3K/Akt/NF-kappaB pathway.	scoparone	46-55	interleukin 1 beta	Homo sapiens	110-118
30075289-3	2018	Within the DH, expression of the pro-inflammatory cytokine interleukin-1beta (IL-1beta) is required for heroin-conditioned peripheral immunomodulation to occur.	Heroin	104-110	interleukin 1 beta	Homo sapiens	78-86
30142362-6	2018	Higher release of IL-1alpha, IL-1beta, IFN-gamma, IL-12p70 and TNF-alpha and a reduced IL-10 secretion after lipopolysaccharide (LPS) stimulation were observed in PBMCs from Arg/Arg T2DM carriers as compared to subjects with the Trp variant.	Arginine	174-177	interleukin 1 beta	Homo sapiens	29-37
29775920-2	2018	In this study we examined whether the IL-1 gene superfamily member, IL-33, also regulates expression of the fatty acid receptor genes in adipocytes.	Fatty Acids	108-118	interleukin 1 beta	Homo sapiens	38-42
30098273-0	2018	Glucose suppresses IL-1beta-induced MMP-1 expression through the FAK, MEK, ERK, and AP-1 signaling pathways.	Glucose	0-7	interleukin 1 beta	Homo sapiens	19-27
30098273-8	2018	Glucose antagonized IL-1beta-promoted phosphorylation of FAK, MEK, ERK, and c-Jun.	Glucose	0-7	interleukin 1 beta	Homo sapiens	20-28
30233731-3	2018	In the present study, anti-inflammatory effects of hesperidin in IL-1beta-stimulated chondrocytes were investigated.	Hesperidin	51-61	interleukin 1 beta	Homo sapiens	65-73
30098273-9	2018	Thus, glucose decreased IL-1beta-induced MMP-1 expression through the FAK, MEK, ERK, and AP-1 signaling cascades.	Glucose	6-13	interleukin 1 beta	Homo sapiens	24-32
28808791-9	2018	There was also a trend for IL-1beta EVOO reduction (-0.3 +- 0.1 pg/mL, P = 0.060).	evoo	36-40	interleukin 1 beta	Homo sapiens	27-35
30233731-4	2018	The results demonstrated that hesperidin treatment markedly decreased nitric oxide and prostaglandin E2 production and markedly downregulated inducible nitric oxide synthase and cyclooxygenase-2 expression in IL-1beta-stimulated OA chondrocytes.	Hesperidin	30-40	interleukin 1 beta	Homo sapiens	209-217
30233731-7	2018	In conclusion, it was revealed for the first time that hesperidin inhibited inflammatory responses in IL-1beta-stimulated human chondrocytes, potentially through inhibiting the activation of the NF-kappaB signaling pathway.	Hesperidin	55-65	interleukin 1 beta	Homo sapiens	102-110
29851525-4	2018	RESULTS: In T2D patients with high blood glucose, IL-1beta expression showed a 2.69-fold increase (p = 0.0380), while IL-6 expression levels were 3.45 fold lower (p = 0.0045) versus control subjects.	Glucose	41-48	interleukin 1 beta	Homo sapiens	50-58
29803697-4	2018	Cyanidin also attenuated endotoxin induced myocardial injury by modulating inflammatory cytokines (Tumor necrosis factor alpha or TNFalpha, Interleukin-1 beta or IL-1beta, macrophage inflammatory protein 2 or MIP-2 and chemokine (C-C motif) ligand 2 also known as monocyte chemoattractant protein 1 or MCP1) and oxidative stress (protein nitration).	cyanidin	0-8	interleukin 1 beta	Homo sapiens	140-158
29803697-4	2018	Cyanidin also attenuated endotoxin induced myocardial injury by modulating inflammatory cytokines (Tumor necrosis factor alpha or TNFalpha, Interleukin-1 beta or IL-1beta, macrophage inflammatory protein 2 or MIP-2 and chemokine (C-C motif) ligand 2 also known as monocyte chemoattractant protein 1 or MCP1) and oxidative stress (protein nitration).	cyanidin	0-8	interleukin 1 beta	Homo sapiens	162-170
29851525-6	2018	In addition, hemoglobin A1C (A1C) levels were positively correlated with IL-1beta expression and fasting plasma glucose (FPG) levels showed a positive correlation with IL-1beta and a negative correlation with IL-6 expression.	Glucose	112-119	interleukin 1 beta	Homo sapiens	168-176
29951874-5	2018	In the present study, we showed that hydrogen peroxide (H2O2) remarkably enhances the expression and release of IL-1beta, TNF-alpha, and IL-6.	Hydrogen Peroxide	37-54	interleukin 1 beta	Homo sapiens	112-120
29959625-0	2018	Spilanthol Inhibits COX-2 and ICAM-1 Expression via Suppression of NF-kappaB and MAPK Signaling in Interleukin-1beta-Stimulated Human Lung Epithelial Cells.	N-isobutyl-2E-decenamide	0-10	interleukin 1 beta	Homo sapiens	99-116
29951874-5	2018	In the present study, we showed that hydrogen peroxide (H2O2) remarkably enhances the expression and release of IL-1beta, TNF-alpha, and IL-6.	Hydrogen Peroxide	56-60	interleukin 1 beta	Homo sapiens	112-120
29951874-6	2018	The maturation of IL-1beta, induced by H2O2, depends on the activation of the NLRP3 inflammasome.	Hydrogen Peroxide	39-43	interleukin 1 beta	Homo sapiens	18-26
29951874-7	2018	Cyclic stretching enhances the maturation of IL-1beta via promoting H2O2-induced NLRP3 inflammasome activation in tenocytes.	Hydrogen Peroxide	68-72	interleukin 1 beta	Homo sapiens	45-53
30136196-11	2018	CONCLUSIONS: These data support a novel role of LMP as a single stimulus for the secretion of IL-1beta from hVSMCs, implying the possibility that hVSMCs are an important initiator of the sterile inflammatory response caused by lysosomal disintegration.	(2~{s},3~{r},4~{s})-2-[(2~{s},3~{r})-1,3-Bis(Oxidanyl)-1-Oxidanylidene-Butan-2-Yl]-4-[(3~{s},5~{s})-5-(Dimethylcarbamoyl)pyrrolidin-3-Yl]sulfanyl-3-Methyl-3,4-Dihydro-2~{h}-Pyrrole-5-Carboxylic Acid	48-51	interleukin 1 beta	Homo sapiens	94-102
29987550-8	2018	Two-month treatment with HCQ resulted in significant decrease in SLEDAI-2K (p &lt; 0.001), anti-dsDNA (p &lt; 0.001), IL-1beta (p = 0.003), IL-6 (p &lt; 0.001) and TNF-alpha (p &lt; 0.001) and a significant increase in CH50 levels (p = 0.012).	Hydroxychloroquine	25-28	interleukin 1 beta	Homo sapiens	118-126
29983334-5	2018	Here, we show that primary human monocytes stimulated with Shiga toxin 1a (Stx1a) through the glycolipid receptor globotriaosylceramide released larger amounts of proinflammatory molecules (IL-1beta, TNFalpha, IL-6, G-CSF, CXCL8, CCL2, CCL4) than Stx1a-treated neutrophils.	globotriaosylceramide	114-135	interleukin 1 beta	Homo sapiens	190-198
29902518-5	2018	Risperidone showed an anti-inflammatory activity, decreasing the release of tumor necrosis factor alpha (TNF-alpha), interleukins 1beta (IL-1 beta) and 6 (IL-6), and increasing interleukin 10 (IL-10).	Risperidone	0-11	interleukin 1 beta	Homo sapiens	137-146
29902518-7	2018	However, haloperidol induced a pro-inflammatory response, increasing the extracellular levels of TNF-alpha and IL-1beta, in addition to decreasing IL-10.	Haloperidol	9-20	interleukin 1 beta	Homo sapiens	111-119
30015859-7	2018	The results revealed that celastrol significantly reduced triglyceride accumulation in the steatotic HepG2 cells, and downregulated the expression levels of TLR4, MyD88 and phospho-NF-kappaBp65, as well as of the downstream inflammatory cytokines interleukin-1beta and tumor necrosis factor alpha.	celastrol	26-35	interleukin 1 beta	Homo sapiens	247-296
30066836-0	2018	Melatonin inhibits epithelial-to-mesenchymal transition in gastric cancer cells via attenuation of IL-1beta/NF-kappaB/MMP2/MMP9 signaling.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	99-107
30006785-6	2018	RESULTS: Ghrelin is correlated with IL-1beta (r = 0.88, p &lt; 0.0001), triglycerides, total cholesterol (TC), and Kt/V.	Ghrelin	9-16	interleukin 1 beta	Homo sapiens	36-44
30006785-7	2018	IL-1beta is the strongest predictor of ghrelin levels (p &lt; 0.0001).	Ghrelin	39-46	interleukin 1 beta	Homo sapiens	0-8
30006785-10	2018	Patients with high ghrelin levels had significantly decreased nitroglycerin-mediated dilation (p = 0.05) and higher IL-1beta levels (p &lt; 0.001); increased NT-proBNP is associated with lower levels of acyl ghrelin (r = - 0.33, p = 0.02) in male patients.	Ghrelin	19-26	interleukin 1 beta	Homo sapiens	116-124
30006785-11	2018	CONCLUSION: The inflammatory marker IL-1beta is in our study the strongest predictor of ghrelin levels while the nutritional marker-total cholesterol is the strongest predictor for acyl ghrelin levels in HD patients.	Ghrelin	88-95	interleukin 1 beta	Homo sapiens	36-44
30006785-12	2018	High endogenous ghrelin level is associated with high IL-1beta and with vascular smooth muscle cell dysfunction.	Ghrelin	16-23	interleukin 1 beta	Homo sapiens	54-62
30270565-2	2018	Our results show that the mRNA levels of IL-1beta, IL-18, NLRP3, ASC, and caspase-1 in the DSS+ZEA-treated group are lower than those in either the DSS or ZEA group, and the protein expression trends are similar.	Dextran Sulfate	91-94	interleukin 1 beta	Homo sapiens	41-49
30270565-2	2018	Our results show that the mRNA levels of IL-1beta, IL-18, NLRP3, ASC, and caspase-1 in the DSS+ZEA-treated group are lower than those in either the DSS or ZEA group, and the protein expression trends are similar.	Zearalenone	95-98	interleukin 1 beta	Homo sapiens	41-49
30054450-7	2018	Accordingly, acute cholesterol depletion in the ER membranes by statins abrogated casp-1 activation and IL-1beta secretion and ablated NLRP3 inflammasome assembly.	Cholesterol	19-30	interleukin 1 beta	Homo sapiens	104-112
30276528-0	2018	Chitosan/hyaluronic acid/plasmid-DNA nanoparticles encoding interleukin-1 receptor antagonist attenuate inflammation in synoviocytes induced by interleukin-1 beta.	Chitosan	0-8	interleukin 1 beta	Homo sapiens	144-162
30276528-0	2018	Chitosan/hyaluronic acid/plasmid-DNA nanoparticles encoding interleukin-1 receptor antagonist attenuate inflammation in synoviocytes induced by interleukin-1 beta.	Hyaluronic Acid	9-24	interleukin 1 beta	Homo sapiens	144-162
30276528-8	2018	RT-qPCR and western blot analysis demonstrated that CS/HA/pIL-1Ra nanoparticles were able to increase IL-1Ra expression in primary synoviocytes, and reduce the mRNA and protein levels of matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-13 (MMP-13), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in IL-1beta-induced synoviocytes.	Chitosan	52-54	interleukin 1 beta	Homo sapiens	332-340
30276528-9	2018	Our findings indicated that CS/HA/pIL-1Ra nanoparticles efficiently transfected synoviocytes and attenuated synovitis induced by IL-1beta, which will provide a potential strategy for OA synovitis.	Chitosan	28-30	interleukin 1 beta	Homo sapiens	129-137
30039507-6	2018	This way we were able to show that the decrease of cerebral ACh triggers increased secretion of IL-1beta, IL-6, TNFalpha, MIP-2 (CCL3), RANTES, MCP1, IFNgamma, and IP-10.	Acetylcholine	60-63	interleukin 1 beta	Homo sapiens	96-104
30216787-5	2018	Both olanzapine and aripiprazole stimulation decreased mRNA levels of IL-1beta, IL-6, and TNF-alpha and resulted in diminished protein concentrations of IL-6 and TNF-alpha in conditioned medium of stimulated PBMC.	Olanzapine	5-15	interleukin 1 beta	Homo sapiens	70-78
30216787-5	2018	Both olanzapine and aripiprazole stimulation decreased mRNA levels of IL-1beta, IL-6, and TNF-alpha and resulted in diminished protein concentrations of IL-6 and TNF-alpha in conditioned medium of stimulated PBMC.	Aripiprazole	20-32	interleukin 1 beta	Homo sapiens	70-78
30216787-7	2018	Similarly, olanzapine and aripiprazole stimulation of the human monocytic cell line THP-1 resulted in a significant decrease in expression and secretion of IL-1beta and TNF-alpha.	Olanzapine	11-21	interleukin 1 beta	Homo sapiens	156-164
30216787-7	2018	Similarly, olanzapine and aripiprazole stimulation of the human monocytic cell line THP-1 resulted in a significant decrease in expression and secretion of IL-1beta and TNF-alpha.	Aripiprazole	26-38	interleukin 1 beta	Homo sapiens	156-164
29429001-6	2018	In the in vitro testing EOCl inhibited the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta) in lipopolysaccharide (LPS) and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in the human keratinocyte cell line (HaCaT).	eocl	24-28	interleukin 1 beta	Homo sapiens	102-110
30066836-3	2018	In the present study, melatonin effectively suppressed interleukin (IL)-1beta-induced EMT in human gastric adenocarcinoma (GA) cells.	Melatonin	22-31	interleukin 1 beta	Homo sapiens	55-77
30066836-4	2018	Sequential treatment of GA cells with melatonin after IL-1beta challenge markedly reversed the IL-1beta-induced morphological changes, reduced cell invasion and migration, increased beta-catenin and E-cadherin expression, and downregulated fibronectin, vimentin, Snail, matrix metalloproteinase (MMP)2 and MMP9 expression.	Melatonin	38-47	interleukin 1 beta	Homo sapiens	54-62
30066836-4	2018	Sequential treatment of GA cells with melatonin after IL-1beta challenge markedly reversed the IL-1beta-induced morphological changes, reduced cell invasion and migration, increased beta-catenin and E-cadherin expression, and downregulated fibronectin, vimentin, Snail, matrix metalloproteinase (MMP)2 and MMP9 expression.	Melatonin	38-47	interleukin 1 beta	Homo sapiens	95-103
30066836-5	2018	Moreover, IL-1beta-induced activation of NF-kappaB was attenuated following treatment with melatonin.	Melatonin	91-100	interleukin 1 beta	Homo sapiens	10-18
30217257-11	2018	Finally, honokiol significantly suppressed IL1B- and TNF-induced NF-kappaB RelA transcriptional activity in primary amnion and myometrial cells.	honokiol	9-17	interleukin 1 beta	Homo sapiens	43-47
29786910-4	2018	Experiments in lipopolysaccharide (LPS)-activated BV2 microglia showed that pretreatment with agathisflavone (5-20 muM) produced significant reduction in the release of tumour necrosis factor-alpha, interleukin-6, interleukin-1beta, NO, and PGE2 from the cells.	agathisflavone	94-108	interleukin 1 beta	Homo sapiens	214-231
29847844-3	2018	While ellagic acid"s antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor-alpha, interleukin-1beta, interleukin-6), and decrease the activity of nuclear factor-kappaB while increasing nuclear factor erythroid 2-related factor 2 expression.	Ellagic Acid	6-18	interleukin 1 beta	Homo sapiens	320-337
30235245-6	2018	Treatment with inflammatory mediators like IL-1beta and TNF-alpha led to short-term upregulation of individual SPs in vitro.	Sodium phenolsulfonate	111-114	interleukin 1 beta	Homo sapiens	43-51
30270563-0	2018	Salidroside attenuates interleukin-1beta-induced inflammation in human osteoarthritis chondrocytes.	rhodioloside	0-11	interleukin 1 beta	Homo sapiens	23-40
30270563-2	2018	However, the effects of salidroside on interleukin (IL)-1beta-stimulated osteoarthritis (OA) chondrocytes remain to be elucidated.	rhodioloside	24-35	interleukin 1 beta	Homo sapiens	39-61
30270563-3	2018	Thus, this study aimed to evaluate the anti-inflammatory effects of salidroside on IL-1beta-stimulated human OA chondrocytes and explore its underlying mechanisms.	rhodioloside	68-79	interleukin 1 beta	Homo sapiens	83-91
30270563-4	2018	Our results showed that salidroside significantly inhibited the production of nitric oxide and prostaglandin E-2, as well as suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2 in IL-1beta-stimulated chondrocytes ( P &lt; .05).	rhodioloside	24-35	interleukin 1 beta	Homo sapiens	210-218
30270563-5	2018	In addition, salidroside also suppressed IL-1beta-induced matrix metalloproteinases production in human OA chondrocytes ( P &lt; .05).	rhodioloside	13-24	interleukin 1 beta	Homo sapiens	41-49
30270563-6	2018	Furthermore, pretreatment with salidroside prevented IL-1beta-induced NF-kappaB activation in OA chondrocytes ( P &lt; .05).	rhodioloside	31-42	interleukin 1 beta	Homo sapiens	53-61
30270563-7	2018	In conclusion, the current study demonstrated that salidroside inhibited the IL-1beta-induced inflammatory response in OA chondrocytes via inhibition of NF-kappaB activation.	rhodioloside	51-62	interleukin 1 beta	Homo sapiens	77-85
30126849-8	2018	Simultaneously, PVT1 inhibition also antagonized the production of inflammatory cytokines upon IL-1beta stimulation, including prostaglandin E2 (PGE2), NO, IL-6, IL-8 and TNF-alpha.	Dinoprostone	127-143	interleukin 1 beta	Homo sapiens	95-103
30363691-2	2018	This study aims to analyze the correlation between serum level of IL-1B and the activity of CPA and to determine whether serum IL-1B could be used to assess the activity of CPA.	cpa	92-95	interleukin 1 beta	Homo sapiens	66-71
30363691-2	2018	This study aims to analyze the correlation between serum level of IL-1B and the activity of CPA and to determine whether serum IL-1B could be used to assess the activity of CPA.	cpa	173-176	interleukin 1 beta	Homo sapiens	127-132
30363691-4	2018	Correlation analysis in the whole subjects showed that only IL-1B level was associated with the activity of CPA.	cpa	108-111	interleukin 1 beta	Homo sapiens	60-65
30363691-9	2018	In subgroup comparative analysis, CT characteristics suggested that high activity of CPA, such as cavitary (27/44 vs 13/44, P=0.003) and aspergilloma lesions (25/44 vs. 11/44, P&lt;0.002), were more frequently found in high IL-1B group.	cpa	85-88	interleukin 1 beta	Homo sapiens	224-229
30363691-12	2018	Interestingly, a significant reduction of IL-1B level was observed after successful resection of CPA lesions.	cpa	97-100	interleukin 1 beta	Homo sapiens	42-47
30363691-13	2018	Conclusion: Higher level of serum IL-1B is associated with more severe cavitary and aspergilloma lesions, which are indicative of more active CPA.	cpa	142-145	interleukin 1 beta	Homo sapiens	34-39
30363691-15	2018	Measuring IL-1B level therefore could be served as a convenient method to monitor the activity of CPA and be a potential predictive/prognostic marker for treatment response.	cpa	98-101	interleukin 1 beta	Homo sapiens	10-15
30231074-9	2018	Two-hour changes in proinflammatory biomarkers hs-CRP, IL-6, IL-8, and IL-1beta were also associated with 10-hr changes in the plasma metabolome, suggesting diverse amino acid, leukotriene, and antioxidant metabolism effects.	Leukotrienes	177-188	interleukin 1 beta	Homo sapiens	71-79
30126633-0	2018	Tannic acid inhibits NLRP3 inflammasome-mediated IL-1beta production via blocking NF-kappaB signaling in macrophages.	Tannins	0-11	interleukin 1 beta	Homo sapiens	49-57
30126633-3	2018	Here, we reported that tannic acid inhibited NLRP3 inflammasome activation by blocking NF-kappaB signaling to suppress IL-1beta secretion.	Tannins	23-34	interleukin 1 beta	Homo sapiens	119-127
30126633-4	2018	We found that the BMDMs (bone marrow-derived macrophages cells) pre-treated with tannic acid blocked caspase-1 cleavage and inhibited IL-1beta secretion in a NLRP3-dependent manner, and suppressed NF-kappaB signaling activation by inhibiting NF-kappaB/P65 nuclear localization, suggesting that tannic acid inhibited NLRP3 inflammasome activation.	Tannins	81-92	interleukin 1 beta	Homo sapiens	134-142
30956867-0	2019	Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1beta via an anti-inflammatory mechanism.	Curcumin	28-36	interleukin 1 beta	Homo sapiens	94-102
30956867-0	2019	Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1beta via an anti-inflammatory mechanism.	Lecithins	41-49	interleukin 1 beta	Homo sapiens	94-102
29940203-5	2018	Two P2RX7 SNPs (rs208294 and rs2230911) significantly modified the associations between a biomarker of TDI exposure (urinary 2,4-toluene diamine) and plasma LPA; two IL1B SNPs (rs16944 and rs1143634) did not.	2,4-diaminotoluene	125-144	interleukin 1 beta	Homo sapiens	166-170
30527115-8	2018	Gene and protein expressions of TNF-alpha and IL-1beta were elevated in cultures with 1000 muM H2O2 compared to controls.	Hydrogen Peroxide	95-99	interleukin 1 beta	Homo sapiens	46-54
29966663-6	2018	In particular, IL-1beta treatment significantly reduced amounts of secreted triglycerides by 97% compared with the control concurrently with enlargement of cytoplasmic lipid droplets in MECs.	Triglycerides	76-89	interleukin 1 beta	Homo sapiens	15-23
29940203-7	2018	In vitro, TDI-exposed bronchial epithelial cells (16HBE14o-) rapidly released ATX and IL-1beta.	Toluene 2,4-Diisocyanate	10-13	interleukin 1 beta	Homo sapiens	86-94
29940203-7	2018	In vitro, TDI-exposed bronchial epithelial cells (16HBE14o-) rapidly released ATX and IL-1beta.	16hbe14o	50-58	interleukin 1 beta	Homo sapiens	86-94
29940203-10	2018	Furthermore, our data suggest that the TDI-induced ATX and IL-1beta responses occur independently.	Toluene 2,4-Diisocyanate	39-42	interleukin 1 beta	Homo sapiens	59-67
30193323-9	2018	Treatment with idelalisib inhibited the IL-1beta-induced expression of IL-6 and IL-8.	idelalisib	15-25	interleukin 1 beta	Homo sapiens	40-48
30254419-3	2018	Results: PMACI results in a significant increase in the production of proinflammatory cytokines, such as TNF-alpha, IL-1beta, MCP-1, IL-6 and as well as histamine.	pmaci	9-14	interleukin 1 beta	Homo sapiens	116-124
30254419-4	2018	Geraniol was found to inhibit both TNF-alpha, IL-1beta and IL-6 protein and mRNA expressions at concentrations of 40, 80, 160 muM.	geraniol	0-8	interleukin 1 beta	Homo sapiens	46-54
30254419-5	2018	In OVA-induced AR models, geraniol treatment was able to suppress AR biomarkers (OVA-specific IgE and IL-1beta as well as histamine) and nasal rub scores.	geraniol	26-34	interleukin 1 beta	Homo sapiens	102-110
30055801-6	2018	IL-1beta induced the expression of ATF3 transcription factor, which in turn binds to cyclic AMP-responsive element sequence in the Ski2 promoter and is responsible for Ski2 promoter induction by IL-1beta.	Cyclic AMP	85-95	interleukin 1 beta	Homo sapiens	0-8
30055801-6	2018	IL-1beta induced the expression of ATF3 transcription factor, which in turn binds to cyclic AMP-responsive element sequence in the Ski2 promoter and is responsible for Ski2 promoter induction by IL-1beta.	Cyclic AMP	85-95	interleukin 1 beta	Homo sapiens	195-203
30258361-8	2018	Of these, lignan 1 (dimethylpinoresinol) inhibited the expression of CSC-induced inflammatory cytokines (IL-1beta, -6, and -8) in vitro in a dose-dependent manner by suppressing the activation of epidermal growth factor receptor (EGFR) and its downstream effectors, including ERK and Akt, in NCI-H292 cells.	lignan 1	10-18	interleukin 1 beta	Homo sapiens	105-125
30258361-8	2018	Of these, lignan 1 (dimethylpinoresinol) inhibited the expression of CSC-induced inflammatory cytokines (IL-1beta, -6, and -8) in vitro in a dose-dependent manner by suppressing the activation of epidermal growth factor receptor (EGFR) and its downstream effectors, including ERK and Akt, in NCI-H292 cells.	dimethylpinoresinol	20-39	interleukin 1 beta	Homo sapiens	105-125
30127006-7	2018	Increased ROS and HIF-1alpha levels, as well as decreased activity of NRF2 in cells lacking BMAL1, resulted in increased production of the proinflammatory cytokine, IL-1beta.	Reactive Oxygen Species	10-13	interleukin 1 beta	Homo sapiens	165-173
29708655-2	2018	Titanium (Ti) forms aggregates with serum proteins, which activate and cause release of the cytokine interleukin (IL-1beta) from human macrophages.	Titanium	0-8	interleukin 1 beta	Homo sapiens	114-122
29717364-4	2018	In HMEC-1, dalteparin inhibited IL1beta-induced NB4 adhesion by 80%, enoxaparin by 52%, and UFH by 44%.	Dalteparin	11-21	interleukin 1 beta	Homo sapiens	32-39
30171593-11	2018	Prostaglandin E2 induces IL-17A independent of IL-23 via IL-1beta and IL-6.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	57-65
29754454-0	2018	Heparinoid suppresses Der p-induced IL-1beta production by inhibiting ERK and p38 MAPK pathways in keratinocytes.	Heparinoids	0-10	interleukin 1 beta	Homo sapiens	36-44
30280762-6	2018	IL-1beta was used to simulate in vitro cultured chondrocytes, which were transfected with miR-320 mimic and/or si-beta-catenin, followed by quantification of miR-320, beta-catenin, MMP-13, and COL2A1.	mir-320	90-97	interleukin 1 beta	Homo sapiens	0-8
29909345-8	2018	Furthermore, macrophage phenotype switching by PLGA-PEG encapsulated Chr NPs significantly suppressed LPS/IFN-gamma induced inflammation by a remarkable reduction in pro-inflammatory cytokine levels, TNF-alpha, IL-1beta, and IL-6.	Polyethylene Glycols	52-55	interleukin 1 beta	Homo sapiens	211-219
29754454-7	2018	We found that HDM allergen-induced interleukin (IL)-1beta release from keratinocytes was inhibited significantly by heparinoid pretreatment without affecting cell viability.	Heparinoids	116-126	interleukin 1 beta	Homo sapiens	35-57
29754454-9	2018	Heparinoid treatment not only decreased intracellular levels of pro-IL-1beta, but also suppressed IL-1beta messenger RNA (mRNA) expression in keratinocytes.	Heparinoids	0-10	interleukin 1 beta	Homo sapiens	64-76
29754454-9	2018	Heparinoid treatment not only decreased intracellular levels of pro-IL-1beta, but also suppressed IL-1beta messenger RNA (mRNA) expression in keratinocytes.	Heparinoids	0-10	interleukin 1 beta	Homo sapiens	68-76
29754454-10	2018	Among the intracellular signalling pathways, the activation of extracellular signal-regulated kinase and p38 pathways, which are required for IL-1beta expression in keratinocytes, was inhibited by heparinoid treatment.	Heparinoids	197-207	interleukin 1 beta	Homo sapiens	142-150
29754454-11	2018	The inhibitory effect of heparinoid on IL-1beta mRNA expression was also confirmed with living skin equivalents.	Heparinoids	25-35	interleukin 1 beta	Homo sapiens	39-47
30126430-11	2018	In THP-1 cells, RIP3 and NLRP3 interaction was enhanced by LPS/ATP stimulation resulting in IL-1beta and IL-18 production.	Adenosine Triphosphate	63-66	interleukin 1 beta	Homo sapiens	92-100
29806884-0	2018	Ligustrazine protects chondrocyte against IL-1beta induced injury by regulation of SOX9/NF-kappaB signaling pathway.	tetramethylpyrazine	0-12	interleukin 1 beta	Homo sapiens	42-50
29806884-2	2018	The study aimed to determine the effect and the underlying mechanism of ligustrazine on interleukin-1beta (IL-1beta)-induced injury in osteoarthritis (OA).	tetramethylpyrazine	72-84	interleukin 1 beta	Homo sapiens	88-105
29806884-2	2018	The study aimed to determine the effect and the underlying mechanism of ligustrazine on interleukin-1beta (IL-1beta)-induced injury in osteoarthritis (OA).	tetramethylpyrazine	72-84	interleukin 1 beta	Homo sapiens	107-115
29806884-10	2018	Moreover, ligustrazine attenuated IL-1beta-induced chondrocytes injury and matrx degradation in chondrocytes.	tetramethylpyrazine	10-22	interleukin 1 beta	Homo sapiens	34-42
29806884-11	2018	Ligustrazine promoted oxidative stress response by increasing SOD level, decreasing MDA level, and inhibiting ROS production in IL-1beta-induced chondrocytes.	tetramethylpyrazine	0-12	interleukin 1 beta	Homo sapiens	128-136
29806884-11	2018	Ligustrazine promoted oxidative stress response by increasing SOD level, decreasing MDA level, and inhibiting ROS production in IL-1beta-induced chondrocytes.	ros	110-113	interleukin 1 beta	Homo sapiens	128-136
29806884-12	2018	Besides, ligustrazine increased SOX9 expression, and SOX9 silencing reversed the effect of ligustrazine on matrx degradation in IL-1beta-injured chondrocytes.	tetramethylpyrazine	91-103	interleukin 1 beta	Homo sapiens	128-136
29806884-12	2018	Besides, ligustrazine increased SOX9 expression, and SOX9 silencing reversed the effect of ligustrazine on matrx degradation in IL-1beta-injured chondrocytes.	matrx	107-112	interleukin 1 beta	Homo sapiens	128-136
29806884-13	2018	Furthermore, ligustrazine blocked NF-kappaB pathway in IL-1beta-induced chondrocytes, and PTDC (NF-kappaB inhibitor) enhanced the effect of ligustrazine on viability, apoptosis, SOX9 expression, and ROS production in IL-1beta-induced chondrocytes.	tetramethylpyrazine	13-25	interleukin 1 beta	Homo sapiens	55-63
29806884-13	2018	Furthermore, ligustrazine blocked NF-kappaB pathway in IL-1beta-induced chondrocytes, and PTDC (NF-kappaB inhibitor) enhanced the effect of ligustrazine on viability, apoptosis, SOX9 expression, and ROS production in IL-1beta-induced chondrocytes.	tetramethylpyrazine	13-25	interleukin 1 beta	Homo sapiens	217-225
29806884-13	2018	Furthermore, ligustrazine blocked NF-kappaB pathway in IL-1beta-induced chondrocytes, and PTDC (NF-kappaB inhibitor) enhanced the effect of ligustrazine on viability, apoptosis, SOX9 expression, and ROS production in IL-1beta-induced chondrocytes.	ptdc	90-94	interleukin 1 beta	Homo sapiens	217-225
29806884-13	2018	Furthermore, ligustrazine blocked NF-kappaB pathway in IL-1beta-induced chondrocytes, and PTDC (NF-kappaB inhibitor) enhanced the effect of ligustrazine on viability, apoptosis, SOX9 expression, and ROS production in IL-1beta-induced chondrocytes.	tetramethylpyrazine	140-152	interleukin 1 beta	Homo sapiens	217-225
29806884-14	2018	These results indicated that ligustrazine protected chondrocytes against IL-1beta-induced injury possibly by regulation of SOX9 and inactivation of NF-kappaB signaling pathway.	tetramethylpyrazine	29-41	interleukin 1 beta	Homo sapiens	73-81
29704279-5	2018	Brazilin was found to reduce the GAG loss from cartilage explants stimulated with IL-1beta and TNF-alpha.	Glycosaminoglycans	33-36	interleukin 1 beta	Homo sapiens	82-90
29356988-7	2018	Prostaglandin E2 (PGE2) was increased by IL-1beta on the third day, and angiopoietin-1 (Ang-1) was inhibited appreciably by TNF-alpha on the seventh day.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	41-49
29356988-7	2018	Prostaglandin E2 (PGE2) was increased by IL-1beta on the third day, and angiopoietin-1 (Ang-1) was inhibited appreciably by TNF-alpha on the seventh day.	Dinoprostone	18-22	interleukin 1 beta	Homo sapiens	41-49
29870142-9	2018	Aberrant cytokine profiles were secreted by SAA MSCs, with increased concentrations of interleukin-6, interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta in the CM.	saa	44-47	interleukin 1 beta	Homo sapiens	153-170
30022657-4	2018	First, graphene oxides (GO) were loaded with redox probes nile blue (NB), methyl blue (MB), and ferrocene (Fc), followed by covalent attachment of anti-cytokine antibodies for IL-6, IL-1beta, and TNF-alpha, respectively, to obtain Ab2-GO-NB, Ab2-GO-MB, and Ab2-GO-Fc, acting as the signal reporters.	graphene oxide	7-22	interleukin 1 beta	Homo sapiens	182-190
30022657-4	2018	First, graphene oxides (GO) were loaded with redox probes nile blue (NB), methyl blue (MB), and ferrocene (Fc), followed by covalent attachment of anti-cytokine antibodies for IL-6, IL-1beta, and TNF-alpha, respectively, to obtain Ab2-GO-NB, Ab2-GO-MB, and Ab2-GO-Fc, acting as the signal reporters.	graphene oxide	24-26	interleukin 1 beta	Homo sapiens	182-190
30022657-6	2018	After that, the capture monoclonal antibody for IL-6, IL-1beta, and TNF-alpha was modified to the carboxylic acid terminated sensing interface.	Carboxylic Acids	98-113	interleukin 1 beta	Homo sapiens	54-62
30186283-9	2018	Results: Both primary monocytes and THP-1 cells, a human monocytic cell line, respond strongly to CaOx crystals in a dose-dependent manner producing TNF-alpha, IL-1beta, IL-8, and IL-10 transcripts.	caox crystals	98-111	interleukin 1 beta	Homo sapiens	160-168
30029058-11	2018	Lastly, we report that humanin treatment inhibited high glucose-induced secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Glucose	56-63	interleukin 1 beta	Homo sapiens	129-146
30029058-11	2018	Lastly, we report that humanin treatment inhibited high glucose-induced secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Glucose	56-63	interleukin 1 beta	Homo sapiens	148-156
30127914-0	2018	Mitochondrial ROS activate interleukin-1beta expression in allergic rhinitis.	Reactive Oxygen Species	14-17	interleukin 1 beta	Homo sapiens	27-44
30127914-7	2018	The results of the present study suggested that patients with AR have raised mitochondrial ROS levels, which may upregulate the expression of IL-1beta, affecting IL-17-production and serving a role in the pathogenesis of AR.	Reactive Oxygen Species	91-94	interleukin 1 beta	Homo sapiens	142-150
30167902-3	2018	In this in vitro study, the effect of NiTi alloy (with two surface modifications - helium and hydrogen) on gene expression profile of selected interleukins (IL-1beta, IL-6 and IL-8) and matrix metalloproteinases (MMP-1 and MMP-2) in human physiological osteoblasts and human osteoarthritic osteoblasts was examined to respond to a question of the different behavior of bone tissue in the implantation of metallic materials in the presence of cells affected by the osteoarthritic process.	Hydrogen	94-102	interleukin 1 beta	Homo sapiens	157-165
30157949-9	2018	Tofacitinib, which inhibits GM-CSF-induced Janus kinase 2 (Jak2)-mediated signal transduction, completely abrogated GM-CSF-induced IL-1beta and caspase-1 (p20) secretion from neutrophils.	tofacitinib	0-11	interleukin 1 beta	Homo sapiens	131-139
30157949-11	2018	Although tofacitinib pretreatment marginally inhibited GM-CSF-induced pro-IL-1beta mRNA expression, tofacitinib completely abrogated NLRP3 protein expression in neutrophils.	tofacitinib	9-20	interleukin 1 beta	Homo sapiens	70-82
29588315-11	2018	Patients with Tangier disease, who carry loss-of-function mutations in ABCA1 and have increased myeloid cholesterol content, showed a marked increase in plasma IL-1beta and IL-18 levels.	Cholesterol	104-115	interleukin 1 beta	Homo sapiens	160-168
30116009-2	2018	Physiological RS generates the activation of sensing proteins, inflammasome activation and mature-IL-1beta secretion, associated with pro-implantatory effects.	rs	14-16	interleukin 1 beta	Homo sapiens	98-106
30158937-6	2018	High glucose concentration was found to elevate dye uptake, a response that was enhanced by IL-1beta/TNF-alpha.	Glucose	5-12	interleukin 1 beta	Homo sapiens	92-100
29993075-8	2018	The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1.	Quercetin	28-37	interleukin 1 beta	Homo sapiens	171-179
29856968-4	2018	In the in vitro model, the ABT-737 treatment diminished the levels of several inflammatory cytokines in this case vascular endothelial growth factor (VEGF), thymic stromal lymphopoietin (TSLP), interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) by inhibiting caspase-1 and NF-kappaB activation in an activated human mast cell line, here HMC-1 cells.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	27-30	interleukin 1 beta	Homo sapiens	194-216
30158937-12	2018	Finally, inhibition of Cx43 hemichannels also prevented the ATP release from endothelial cells treated with IL-1beta/TNF-alpha and high glucose.	Adenosine Triphosphate	60-63	interleukin 1 beta	Homo sapiens	108-116
29771572-10	2018	PYR-41 treatment decreased the expression of proinflammatory cytokines IL-6 and IL-1beta as well as chemokines keratinocyte chemoattractant and macrophage inflammatory protein-2 in the gut and lung, which leads to inhibition of neutrophils infiltrating into these organs.	4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester	0-6	interleukin 1 beta	Homo sapiens	80-88
29946002-3	2018	This study investigated mechanisms underlying CMH by comparing IL-1beta-induced gene expression profiles between asthma and control-derived ASMCs and the subsequent paracrine influence on airway epithelial mucus production in vitroIL-1beta-treated ASMCs from asthmatic patients and healthy donors were profiled using microarray analysis and ELISA.	vitroil-1beta	226-239	interleukin 1 beta	Homo sapiens	63-71
29946002-3	2018	This study investigated mechanisms underlying CMH by comparing IL-1beta-induced gene expression profiles between asthma and control-derived ASMCs and the subsequent paracrine influence on airway epithelial mucus production in vitroIL-1beta-treated ASMCs from asthmatic patients and healthy donors were profiled using microarray analysis and ELISA.	asmcs	248-253	interleukin 1 beta	Homo sapiens	63-71
29946002-4	2018	Air-liquid interface (ALI)-cultured CALU-3 and primary airway epithelial cells were treated with identified candidates and mucus production assessed.The IL-1beta-induced CCL20 expression and protein release was increased in ASMCs from moderate compared with mild asthmatic patients and healthy controls.	asmcs	224-229	interleukin 1 beta	Homo sapiens	153-161
29946002-5	2018	IL-1beta induced lower MIR146A expression in asthma-derived ASMCs compared with controls.	asmcs	60-65	interleukin 1 beta	Homo sapiens	0-8
30096783-0	2018	Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells.	Phosphorylcholine	0-14	interleukin 1 beta	Homo sapiens	91-99
30096783-0	2018	Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells.	modified lipooligosaccharides	15-44	interleukin 1 beta	Homo sapiens	91-99
30096783-0	2018	Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells.	Adenosine Triphosphate	79-82	interleukin 1 beta	Homo sapiens	91-99
30096783-2	2018	Recently, we demonstrated that free phosphocholine (PC) and PC-modified lipooligosaccharides (PC-LOS) from Haemophilus influenzae, an opportunistic pathogen of the upper and lower airways, function as unconventional nicotinic agonists and efficiently inhibit the ATP-induced release of monocytic IL-1beta.	Phosphorylcholine	36-50	interleukin 1 beta	Homo sapiens	296-304
30096783-2	2018	Recently, we demonstrated that free phosphocholine (PC) and PC-modified lipooligosaccharides (PC-LOS) from Haemophilus influenzae, an opportunistic pathogen of the upper and lower airways, function as unconventional nicotinic agonists and efficiently inhibit the ATP-induced release of monocytic IL-1beta.	Phosphorylcholine	52-54	interleukin 1 beta	Homo sapiens	296-304
30096783-2	2018	Recently, we demonstrated that free phosphocholine (PC) and PC-modified lipooligosaccharides (PC-LOS) from Haemophilus influenzae, an opportunistic pathogen of the upper and lower airways, function as unconventional nicotinic agonists and efficiently inhibit the ATP-induced release of monocytic IL-1beta.	lipid-linked oligosaccharides	72-92	interleukin 1 beta	Homo sapiens	296-304
30096783-6	2018	We demonstrate that PC and PC-LOS efficiently inhibit ATP-mediated IL-1beta release by A549 and Calu-3 cells via nicotinic acetylcholine receptors containing subunits alpha7, alpha9, and/or alpha10.	Phosphorylcholine	20-22	interleukin 1 beta	Homo sapiens	67-75
30096783-6	2018	We demonstrate that PC and PC-LOS efficiently inhibit ATP-mediated IL-1beta release by A549 and Calu-3 cells via nicotinic acetylcholine receptors containing subunits alpha7, alpha9, and/or alpha10.	pc-los	27-33	interleukin 1 beta	Homo sapiens	67-75
30096783-6	2018	We demonstrate that PC and PC-LOS efficiently inhibit ATP-mediated IL-1beta release by A549 and Calu-3 cells via nicotinic acetylcholine receptors containing subunits alpha7, alpha9, and/or alpha10.	Adenosine Triphosphate	54-57	interleukin 1 beta	Homo sapiens	67-75
30011214-11	2018	However, only the indo-dendrimer complexes showed a significant reduction of IL-1beta in LPS-treated THP-1 cells, which was not present in the control with free indomethacin.	Indomethacin	161-173	interleukin 1 beta	Homo sapiens	77-85
29951691-0	2018	Synthesis of interleukin 1 beta and interleukin 6 in human lymphocytes is stimulated by tributyltin.	tributyltin	88-99	interleukin 1 beta	Homo sapiens	13-31
30168624-7	2018	Modified LDL co-stimulated with ATCC33277 exhibited regulatory effects on caspase 1 activity, IL-1beta release and CD36 expression in THP1 cells, whereas W50 induced more modest responses in THP1 cells.	atcc33277	32-41	interleukin 1 beta	Homo sapiens	94-102
29951691-3	2018	Secretion of both interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) from human lymphocytes can be increased dependent upon the level of TBT exposure.	tributyltin	140-143	interleukin 1 beta	Homo sapiens	18-35
30208836-5	2018	SO, ED, and GL stimulated production of pro-inflammatory IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, TNF-alpha and anti-inflammatory IL-10.	glycylleucine	12-14	interleukin 1 beta	Homo sapiens	68-76
29803171-4	2018	In the current study, we addressed for the first time the inhibitory property of gemigliptin against interleukin-1beta (IL-1beta)-induced degradation of type II collagen in human chondrocytes.	LC15-0444	81-92	interleukin 1 beta	Homo sapiens	101-118
29803171-4	2018	In the current study, we addressed for the first time the inhibitory property of gemigliptin against interleukin-1beta (IL-1beta)-induced degradation of type II collagen in human chondrocytes.	LC15-0444	81-92	interleukin 1 beta	Homo sapiens	120-128
29582166-0	2018	Restoring the IL-1beta/NF-kappaB-induced impaired chondrogenesis by diallyl disulfide in human adipose-derived mesenchymal stem cells via attenuation of reactive oxygen species and elevation of antioxidant enzymes.	diallyl disulfide	68-85	interleukin 1 beta	Homo sapiens	14-22
29763588-5	2018	Intriguingly, LPS-induced high expression and generation of inflammatory cytokines (i.e., IL-6, TNF-alpha and IL-1beta) was notably reversed by glycyrrhizin pre-treatment.	Glycyrrhizic Acid	144-156	interleukin 1 beta	Homo sapiens	110-118
29806793-0	2018	Curcumin reduces the expression of interleukin 1beta and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet"s disease.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	35-52
29701288-16	2018	Within the limit of this study, the results showed that 12 weeks after BAHS implantation the gene expression of some inflammatory cytokines (IL-8 and IL-1beta) is still relatively high compared with the baseline, steady-state, expression.	bahs	71-75	interleukin 1 beta	Homo sapiens	150-158
30116326-2	2018	In addition, the influence of vitamin D deficiency was investigated on the expression of cytokines IL-1beta, IL-6 and TNF-alpha in intervertebral disc lesions of patients.	Vitamin D	30-39	interleukin 1 beta	Homo sapiens	99-107
30116326-11	2018	In the control group, vitamin D content was negatively correlated with the expression of IL-1beta, IL-6 and TNF-alpha.	Vitamin D	22-31	interleukin 1 beta	Homo sapiens	89-97
29806793-6	2018	RESULTS: Treatment with 30 microg/ml curcumin significantly down-regulated mRNA expression of IL-1beta (p &lt; .05) and protein production of IL-6 (p &lt; .05) in M1 macrophages from BD patients but not in M1 macrophage from controls.	Curcumin	37-45	interleukin 1 beta	Homo sapiens	94-102
29582166-0	2018	Restoring the IL-1beta/NF-kappaB-induced impaired chondrogenesis by diallyl disulfide in human adipose-derived mesenchymal stem cells via attenuation of reactive oxygen species and elevation of antioxidant enzymes.	Reactive Oxygen Species	153-176	interleukin 1 beta	Homo sapiens	14-22
29582166-3	2018	This study aims to explore the effects of diallyl disulfide (DADS) on IL-1beta-mediated inflammation and oxidative stress in human adipose derived mesenchymal stem cells (hADSCs) during chondrogenesis.	diallyl disulfide	42-59	interleukin 1 beta	Homo sapiens	70-78
29582166-3	2018	This study aims to explore the effects of diallyl disulfide (DADS) on IL-1beta-mediated inflammation and oxidative stress in human adipose derived mesenchymal stem cells (hADSCs) during chondrogenesis.	diallyl disulfide	61-65	interleukin 1 beta	Homo sapiens	70-78
29890415-6	2018	Montelukast has an inhibitory effect on the inflammatory microenvironment of RA by decreasing the secretion of IL-6, IL-8, MMP-3 and MMP-13 in FLSs induced by IL-1beta.	montelukast	0-11	interleukin 1 beta	Homo sapiens	159-167
29890415-7	2018	Notably, treatment with montelukast attenuated IL-1beta-induced phosphorylation of IkappaBalpha, IkappaBalpha degradation, nuclear translocation of p65 and NF-kappaB activity to express a luciferase reporter gene in FLSs.	montelukast	24-35	interleukin 1 beta	Homo sapiens	47-55
29913427-3	2018	Results showed that formononetin significantly reduced the production of TNF-alpha, IL-6 and IL-1beta, nitrite and PGE2, as well as protein levels of iNOS and COX-2.	formononetin	20-32	interleukin 1 beta	Homo sapiens	93-101
29582166-5	2018	The effects of DADS on IL-1beta-induced intracellular ROS generation and lipid peroxidation were evaluated in hADSCs.	diallyl disulfide	15-19	interleukin 1 beta	Homo sapiens	23-31
29582166-5	2018	The effects of DADS on IL-1beta-induced intracellular ROS generation and lipid peroxidation were evaluated in hADSCs.	Reactive Oxygen Species	54-57	interleukin 1 beta	Homo sapiens	23-31
29582166-8	2018	The results showed that addition of DADS significantly enhanced the mRNA expression levels of antioxidant enzymes as well as reduced ROS elevation, lipid peroxidation, IkappaBalpha activation and NF-kappaB nuclear translocation in hADSCs treated with IL-1beta.	diallyl disulfide	36-40	interleukin 1 beta	Homo sapiens	251-259
29582166-9	2018	In addition, DADS could significantly increase the expression levels of IL-1beta-induced impaired chondrogenic marker genes in differentiated hADSCs.	diallyl disulfide	13-17	interleukin 1 beta	Homo sapiens	72-80
29108965-6	2018	Furthermore, administration of IL-1beta into the airways stimulated lactate production and expression of glycolytic enzymes, with notable expression of lactate dehydrogenase A occurring in the airway epithelium.	Lactic Acid	68-75	interleukin 1 beta	Homo sapiens	31-39
29108965-13	2018	A positive correlation was observed between sputum lactate and IL-1beta levels, and lactate content correlated negatively with lung function.	Lactic Acid	51-58	interleukin 1 beta	Homo sapiens	63-71
29752727-5	2018	GCF levels of IL-1beta were higher in pSS group than healthy group (p = 0.035).	pss	38-41	interleukin 1 beta	Homo sapiens	14-22
29709340-12	2018	Pretreatment and co-incubation of pulp cells by 5z-7oxozeaenol (1 and 2.5 muM) and U0126 (10 and 20 muM) prevented the IL-1beta-induced IL-8 and uPA expression.	5-7-oxo-zeaenol	48-62	interleukin 1 beta	Homo sapiens	119-127
29709340-12	2018	Pretreatment and co-incubation of pulp cells by 5z-7oxozeaenol (1 and 2.5 muM) and U0126 (10 and 20 muM) prevented the IL-1beta-induced IL-8 and uPA expression.	U 0126	83-88	interleukin 1 beta	Homo sapiens	119-127
29709340-13	2018	5z-7oxozeaenol and U0126 also attenuated the IL-1beta-induced IL-8 and uPA secretion.	5-7-oxo-zeaenol	0-14	interleukin 1 beta	Homo sapiens	45-53
29709340-13	2018	5z-7oxozeaenol and U0126 also attenuated the IL-1beta-induced IL-8 and uPA secretion.	U 0126	19-24	interleukin 1 beta	Homo sapiens	45-53
29345311-7	2018	Exposure to 2 muM cinacalcet elevated mRNA expression of NLRP3, CASP-1, and IL-1beta, as well as an increase in pro-IL-1beta protein.	Cinacalcet	18-28	interleukin 1 beta	Homo sapiens	76-84
29345311-7	2018	Exposure to 2 muM cinacalcet elevated mRNA expression of NLRP3, CASP-1, and IL-1beta, as well as an increase in pro-IL-1beta protein.	Cinacalcet	18-28	interleukin 1 beta	Homo sapiens	112-124
30110204-13	2018	YH23537 upregulated tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-3 in IL-1beta-stimulated human OA chondrocytes.	yh23537	0-7	interleukin 1 beta	Homo sapiens	81-89
29866791-0	2018	Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1beta Level.	naringenin	0-10	interleukin 1 beta	Homo sapiens	65-73
29866791-6	2018	Furthermore, we found that naringenin was able to ameliorate RILI through downregulation of IL-1beta and restoration of the homeostasis of inflammatory factors.	naringenin	27-37	interleukin 1 beta	Homo sapiens	92-100
29859292-9	2018	RESULTS: A multiple-SNP analysis showed TC haplotype for IL1A and IL1B SNPs to be significantly associated with a decreased risk of the parasitic infection (OR 0.41, P&lt;=0.050).	Technetium	40-42	interleukin 1 beta	Homo sapiens	66-70
30150146-7	2018	Consequently, we found that they responded to ADP or UTP treatment with a transient increase of intracellular Ca2+ concentration, and that they could show reactive response to interleukin-1beta treatments.	Adenosine Diphosphate	46-49	interleukin 1 beta	Homo sapiens	176-193
30150146-7	2018	Consequently, we found that they responded to ADP or UTP treatment with a transient increase of intracellular Ca2+ concentration, and that they could show reactive response to interleukin-1beta treatments.	Uridine Triphosphate	53-56	interleukin 1 beta	Homo sapiens	176-193
29891588-4	2018	Berberine treatment improved DSS-induced colitis symptoms, attenuated inflammatory markers (myeloperoxidase, tumor necrosis factor-alpha, and interleukin-1beta and -6), and enhanced P-gp expression in a dose-dependent manner.	Berberine	0-9	interleukin 1 beta	Homo sapiens	142-166
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	28-31	interleukin 1 beta	Homo sapiens	171-179
29956729-8	2018	The results demonstrated that pyroptosis in H2O2-treated HLECs, and the mRNA and protein expression of caspase-1 and IL-1beta, was significantly increased compared with control cells.	Hydrogen Peroxide	44-48	interleukin 1 beta	Homo sapiens	117-125
29956729-10	2018	When HLECs were cotreated with a caspase-1 inhibitor and 100 microM H2O2, caspase-1 and IL-1beta expression were decreased compared with the 100 microM H2O2-only group.	Hydrogen Peroxide	68-72	interleukin 1 beta	Homo sapiens	88-96
29956729-10	2018	When HLECs were cotreated with a caspase-1 inhibitor and 100 microM H2O2, caspase-1 and IL-1beta expression were decreased compared with the 100 microM H2O2-only group.	Hydrogen Peroxide	152-156	interleukin 1 beta	Homo sapiens	88-96
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	123-126	interleukin 1 beta	Homo sapiens	152-169
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	123-126	interleukin 1 beta	Homo sapiens	171-179
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	Hydrogen Peroxide	289-293	interleukin 1 beta	Homo sapiens	152-169
30228942-1	2018	In preclinical models, IL-1beta inhibition could enhance the efficacy of fluorouracil (5-FU).	Fluorouracil	73-85	interleukin 1 beta	Homo sapiens	23-31
30106035-2	2018	Noradrenaline inhibits microglial activation and suppresses pro-inflammatory mediator production (e.g., tumor necrosis factor-alpha, interleukin-1beta &amp; inducible nitric oxide synthase activity), thus limiting the cytotoxicity of midbrain dopaminergic neurons in response to an inflammatory stimulus.	Norepinephrine	0-13	interleukin 1 beta	Homo sapiens	133-150
30228942-1	2018	In preclinical models, IL-1beta inhibition could enhance the efficacy of fluorouracil (5-FU).	Fluorouracil	87-91	interleukin 1 beta	Homo sapiens	23-31
29894720-0	2018	LTB4 and PGE2 modulate the release of MIP-1alpha and IL-1beta by cells stimulated with Bothrops snake venoms.	Leukotriene B4	0-4	interleukin 1 beta	Homo sapiens	53-61
30055667-7	2018	For bacteria-treated cultures, TBBPA generally inhibited P4, IL-1beta, and HO-1 production but enhanced TNF-alpha and IL-6 production.	tetrabromobisphenol A	31-36	interleukin 1 beta	Homo sapiens	61-69
30055667-9	2018	TBBPA may also function as a risk modifier where it enhances bacteria-stimulated production TNF-alpha and IL-6 but reduces HO-1 production, however, this was balanced by reductions in IL-1beta.	tetrabromobisphenol A	0-5	interleukin 1 beta	Homo sapiens	184-192
29894720-0	2018	LTB4 and PGE2 modulate the release of MIP-1alpha and IL-1beta by cells stimulated with Bothrops snake venoms.	Dinoprostone	9-13	interleukin 1 beta	Homo sapiens	53-61
29894720-4	2018	Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom.	Leukotriene B4	38-52	interleukin 1 beta	Homo sapiens	122-139
29894720-4	2018	Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom.	Leukotriene B4	38-52	interleukin 1 beta	Homo sapiens	141-149
29894720-4	2018	Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom.	Dinoprostone	64-80	interleukin 1 beta	Homo sapiens	122-139
29894720-4	2018	Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom.	Dinoprostone	64-80	interleukin 1 beta	Homo sapiens	141-149
29894720-4	2018	Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom.	Dinoprostone	82-86	interleukin 1 beta	Homo sapiens	122-139
29894720-4	2018	Recently, our group demonstrated that leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) regulate macrophage production of interleukin-1beta (IL-1beta) induced by scorpion venom.	Dinoprostone	82-86	interleukin 1 beta	Homo sapiens	141-149
30105015-2	2018	CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of interleukin-1beta (IL-1beta) and of the IL-1beta-dependent cytokine IL-6.	Phosphorylcholine	9-23	interleukin 1 beta	Homo sapiens	111-128
30108544-10	2018	our results show that artesunate was able to reduce the TBI-induced lesion, it also showed an anti-inflammatory action through the inhibition of Nf-kb, release of proinflammatory cytokines IL-1beta and TNF-alpha and through the inhibition NLRP3 inflammasome complex, furthermore was able to reduce the activation of astrocytes and microglia (GFAP, Iba-1).	Artesunate	22-32	interleukin 1 beta	Homo sapiens	189-197
30105015-2	2018	CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of interleukin-1beta (IL-1beta) and of the IL-1beta-dependent cytokine IL-6.	Phosphorylcholine	9-23	interleukin 1 beta	Homo sapiens	130-138
30105015-2	2018	CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of interleukin-1beta (IL-1beta) and of the IL-1beta-dependent cytokine IL-6.	Phosphorylcholine	9-23	interleukin 1 beta	Homo sapiens	151-159
30105015-2	2018	CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of interleukin-1beta (IL-1beta) and of the IL-1beta-dependent cytokine IL-6.	Phosphorylcholine	25-27	interleukin 1 beta	Homo sapiens	111-128
30105015-2	2018	CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of interleukin-1beta (IL-1beta) and of the IL-1beta-dependent cytokine IL-6.	Phosphorylcholine	25-27	interleukin 1 beta	Homo sapiens	130-138
30105015-2	2018	CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of interleukin-1beta (IL-1beta) and of the IL-1beta-dependent cytokine IL-6.	Phosphorylcholine	25-27	interleukin 1 beta	Homo sapiens	151-159
30105015-5	2018	Here, we demonstrate that CRP, in association with PC, efficiently reduces ATP-induced inflammasome activation and IL-1beta release from human peripheral blood mononuclear leukocytes and monocytic U937 cells.	Phosphorylcholine	51-53	interleukin 1 beta	Homo sapiens	115-123
30090014-11	2018	Results: The results showed that IL-1beta statistically significantly increased the expression of IL-6, PGE-2, and COX-2 in orbital fibroblasts.	Prostaglandins E	104-107	interleukin 1 beta	Homo sapiens	33-41
28801211-9	2018	RESULTS: IL-1beta-stimulated OA chondrocytes showed high levels of ROS generation, mitochondrial membrane damage, accumulation of damaged mitochondria and higher incidence of apoptosis.	Reactive Oxygen Species	67-70	interleukin 1 beta	Homo sapiens	9-17
28801211-10	2018	IL-1beta stimulation of chondrocytes with depleted Parkin expression resulted in sustained high levels of ROS, accumulation of damaged/dysfunctional mitochondria and enhanced apoptosis.	Reactive Oxygen Species	106-109	interleukin 1 beta	Homo sapiens	0-8
30054566-6	2018	IL-1beta and IFN- gamma significantly increased IL-6 production in HNECs derived from CRS patients and controls, however, a dose-dependent effect was observed in CRS-derived HNECs only.	3-cresol	86-89	interleukin 1 beta	Homo sapiens	0-8
30054566-6	2018	IL-1beta and IFN- gamma significantly increased IL-6 production in HNECs derived from CRS patients and controls, however, a dose-dependent effect was observed in CRS-derived HNECs only.	3-cresol	162-165	interleukin 1 beta	Homo sapiens	0-8
30090014-14	2018	Chitosan downregulated expression of IL-1beta-stimulated IL-6, COX-2, and PGE-2 and downregulated phosphorylation of JNK.	Prostaglandins E	74-77	interleukin 1 beta	Homo sapiens	37-45
28478304-3	2018	In turn, increased amounts of ROS/RNS and pro-inflammatory cytokines TNFalpha, IL-1beta, IL-6 led to the irreversible DNA damage, persistent DDR activation, proliferation inhibition, reduction in cell growth and immune impairment.	ros	30-33	interleukin 1 beta	Homo sapiens	79-87
30037344-10	2018	Quantitative real-time PCR analysis revealed that curcumin, but not rapamycin, reduced the levels of inflammatory markers IL-6 and COX-2 in cultured astrocytes that were challenged with IL-1beta.	Curcumin	50-58	interleukin 1 beta	Homo sapiens	186-194
28478304-3	2018	In turn, increased amounts of ROS/RNS and pro-inflammatory cytokines TNFalpha, IL-1beta, IL-6 led to the irreversible DNA damage, persistent DDR activation, proliferation inhibition, reduction in cell growth and immune impairment.	Radon	34-37	interleukin 1 beta	Homo sapiens	79-87
30093956-9	2018	Vincamine also exerted anti-inflammatory activities by decreasing IL-6, IL-8, IL-1beta, TNF-alpha, TGF-beta expression.	Vincamine	0-9	interleukin 1 beta	Homo sapiens	78-86
29678772-7	2018	The improvement in negative symptoms with minocycline was significantly correlated with the reduction of IL-1beta and IL-6 serum levels (P &lt; 0.05).	Minocycline	42-53	interleukin 1 beta	Homo sapiens	105-113
29763636-5	2018	In addition, leonurine decreased representative M1 marker (iNOS and CD86) expression, NLRP3 inflammasome activation and M1 cytokine (TNF-alpha and IL-1beta) production.	leonurine	13-22	interleukin 1 beta	Homo sapiens	147-155
29763636-6	2018	In the in vitro cultured RAW264.7 and human monocyte-derived macrophages (MDMs), blockade of COX-2/mPGES-1 and 5-LOX by leonurine inhibited macrophage M1 polarization and NLRP3 inflammasome activation in response to MSU crystals, and thus down-regulated IL-1beta and TNF-alpha with STAT1 and NF-kappaB inactivation.	leonurine	120-129	interleukin 1 beta	Homo sapiens	254-262
29763636-8	2018	Furthermore, leonurine prevented a positive feedback loop between COX-2/mPGES-1/5-LOX and IL-1beta/TNF-alpha in MSU crystal-induced inflammation.	leonurine	13-22	interleukin 1 beta	Homo sapiens	90-98
29763636-9	2018	Together, simultaneous down-regulation of COX-2/mPGES-1 and 5-LOX by leonurine ameliorates MSU crystal-induced inflammation through decreasing IL-1beta and TNF-alpha production.	leonurine	69-78	interleukin 1 beta	Homo sapiens	143-151
29678772-6	2018	RESULTS: Subjects receiving high dose minocycline not only had greater improvements on the SANS total scores and PANSS negative subscale scores (P &lt; 0.01), but also had greater reductions in IL-1beta and IL-6 serum levels (P &lt; 0.01) when compared with those receiving low dose minocycline or placebo.	Minocycline	38-49	interleukin 1 beta	Homo sapiens	194-202
30034795-9	2018	In IL-1beta-administrated CHON-001 cells, miR-126 inhibitor suppressed the effect of IL-1beta on cell viability, migration, apoptosis, and inflammatory response.	chon	26-30	interleukin 1 beta	Homo sapiens	3-11
29996768-9	2018	Short-term high glucose increased the expression of IL-1beta.	Glucose	16-23	interleukin 1 beta	Homo sapiens	52-60
29996768-10	2018	Long-term high glucose increased the expression of IL-1beta and TNFalpha but reduced the expression of IL-12p40 and nitric oxide production in M1 macrophage.	Glucose	15-22	interleukin 1 beta	Homo sapiens	51-59
30123073-3	2018	Our study clarified that alcohol accumulation could aggravate the progress of esophagitis by inducing pyroptosis; however, Ac-YVAD-CMK, an inhibitor of caspase-1, could effectively suppress the expression of IL-1beta and IL-18 both in vivo and in vitro, reducing the inflammatory response, which is promised to be an agent to inhibit the progression of esophagitis.	Alcohols	25-32	interleukin 1 beta	Homo sapiens	208-216
30034795-9	2018	In IL-1beta-administrated CHON-001 cells, miR-126 inhibitor suppressed the effect of IL-1beta on cell viability, migration, apoptosis, and inflammatory response.	chon	26-30	interleukin 1 beta	Homo sapiens	85-93
29971445-7	2018	Similarly, H2O2 upregulated TRPM2 protein expression by 80%, and induced both NLRP3 inflammasome activation and increased bioactive IL-1beta secretion (P &lt;= 0.036), whereas ACA pretreatment suppressed these effects (P &lt;= 0.029).	Hydrogen Peroxide	11-15	interleukin 1 beta	Homo sapiens	132-140
29973222-10	2018	Furthermore, treatment with RhoA siRNA, Y27632, or SP600125 suppressed the IL-1beta-induced neuronal differentiation.	Y 27632	40-46	interleukin 1 beta	Homo sapiens	75-83
29973222-10	2018	Furthermore, treatment with RhoA siRNA, Y27632, or SP600125 suppressed the IL-1beta-induced neuronal differentiation.	pyrazolanthrone	51-59	interleukin 1 beta	Homo sapiens	75-83
30116142-4	2018	Folic acid and the mixture of methyl donors reduced interleukin 1 beta (IL1B) and tumour necrosis factor (TNF) expression as well as protein secretion by these cells.	Folic Acid	0-10	interleukin 1 beta	Homo sapiens	52-70
30116142-4	2018	Folic acid and the mixture of methyl donors reduced interleukin 1 beta (IL1B) and tumour necrosis factor (TNF) expression as well as protein secretion by these cells.	Folic Acid	0-10	interleukin 1 beta	Homo sapiens	72-76
29941706-9	2018	Ac-YVAD-cmk blocked the activation of caspase-1 and subsequently attenuated IL-1beta secretion (181.00 +- 45.24 pg/ml in LPS + MPA + YVAD group vs. 588.00 +- 41.99 pg/ml in LPS + MPA group, P = 0.014).	ac-yvad	0-7	interleukin 1 beta	Homo sapiens	76-84
29941706-9	2018	Ac-YVAD-cmk blocked the activation of caspase-1 and subsequently attenuated IL-1beta secretion (181.00 +- 45.24 pg/ml in LPS + MPA + YVAD group vs. 588.00 +- 41.99 pg/ml in LPS + MPA group, P = 0.014).	YVAD	3-7	interleukin 1 beta	Homo sapiens	76-84
29973533-5	2018	Kahweol decreased the LPS-induced production of interleukin 1 alpha, interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha.	kahweol	0-7	interleukin 1 beta	Homo sapiens	69-87
29709093-7	2018	Magnesium sulfate administered 1-hour post-LPS inhibited FM secretion of IL-1beta, IL-6, G-CSF, RANTES, and TNFalpha.	Magnesium Sulfate	0-17	interleukin 1 beta	Homo sapiens	73-81
29709093-9	2018	Magnesium sulfate delivered 1- hour post-LPS inhibited LPS-induced caspase-1 activity, and inhibited the augmented IL-1beta response triggered by combination viral dsRNA and LPS.	Magnesium Sulfate	0-17	interleukin 1 beta	Homo sapiens	115-123
29730525-5	2018	These cholesterol crystals induce a dose-dependent secretion of mature Interleukin 1-beta (IL-1beta) from human monocytes and macrophages (an NLRP3 inflammasome-mediated pathway).	Cholesterol	6-17	interleukin 1 beta	Homo sapiens	71-89
29730525-5	2018	These cholesterol crystals induce a dose-dependent secretion of mature Interleukin 1-beta (IL-1beta) from human monocytes and macrophages (an NLRP3 inflammasome-mediated pathway).	Cholesterol	6-17	interleukin 1 beta	Homo sapiens	91-99
29730525-6	2018	Since IL-1beta production leads to increased levels of IL-6 and C-reactive protein, this could be a mechanistic link between early deposition of cholesterol crystals within the vessel wall to the macrophage-monocyte interactions that initiate fatty streaks and promote local atherosclerotic progression.	Cholesterol	145-156	interleukin 1 beta	Homo sapiens	6-14
29655164-8	2018	Lastly, our results indicate that bornyl acetate mitigated expression of the pro-inflammatory cytokines TNF-alpha and IL-1beta.	bornyl acetate	34-48	interleukin 1 beta	Homo sapiens	118-126
29653184-7	2018	Furthermore, the mRNA expression of inflammatory mediators such as Il-1beta, Il-6, iNos, and Cox-2 was more attenuated in 17beta-estradiol-treated group than in vehicle-treated group.	Estradiol	122-138	interleukin 1 beta	Homo sapiens	67-75
29669302-7	2018	Sodium ascorbate exerts anti-inflammatory activity by reducing the expression of NFkappaB, CRP, TNF-alpha, IL-1beta and IL-6 associated with enhanced expression of the anti-inflammatory cytokines, IL-4 and IL-10.	Ascorbic Acid	0-16	interleukin 1 beta	Homo sapiens	107-115
29683202-2	2018	Crystalline cholesterol and uric acid activate the PRR Nod-like receptor protein (NLRP)3 inflammasome to release interleukin (IL)-1beta and result in vigorous inflammation.	Cholesterol	12-23	interleukin 1 beta	Homo sapiens	113-135
29683202-2	2018	Crystalline cholesterol and uric acid activate the PRR Nod-like receptor protein (NLRP)3 inflammasome to release interleukin (IL)-1beta and result in vigorous inflammation.	Uric Acid	28-37	interleukin 1 beta	Homo sapiens	113-135
28956662-0	2018	Leptin alone and in combination with interleukin-1-beta induced cartilage degradation potentially inhibited by EPA and DHA.	Eicosapentaenoic Acid	111-114	interleukin 1 beta	Homo sapiens	37-55
29896237-6	2018	It was demonstrated that IL-1beta secretion was suppressed by IL-31 treatment from LPS-challenged peritoneal macrophages following adenosine triphosphate stimulation, which is an activator of NLR family, pyrin domain-containing 3 (NLRP3).	Adenosine Triphosphate	131-153	interleukin 1 beta	Homo sapiens	25-33
28956662-0	2018	Leptin alone and in combination with interleukin-1-beta induced cartilage degradation potentially inhibited by EPA and DHA.	Docosahexaenoic Acids	119-122	interleukin 1 beta	Homo sapiens	37-55
28956662-10	2018	Interestingly, both EPA and DHA could inhibit cartilage damage induced by leptin plus IL1beta by reducing the activation of NFkappaB and JNK, which led to the decrease of ADAMTS4 secretion.	Eicosapentaenoic Acid	20-23	interleukin 1 beta	Homo sapiens	86-93
28956662-10	2018	Interestingly, both EPA and DHA could inhibit cartilage damage induced by leptin plus IL1beta by reducing the activation of NFkappaB and JNK, which led to the decrease of ADAMTS4 secretion.	Docosahexaenoic Acids	28-31	interleukin 1 beta	Homo sapiens	86-93
28875725-3	2018	The aim of this study was to determine the association between the maternal interleukin-1beta (IL-1beta) haplotype and expression variation with oxides of nitrogen (NOx) levels, and thereafter investigate the IL-1beta haplotype-specific effects of NOx exposure levels, IL-1beta mRNA expression and other variables on gestational age.	nicotine 1-N-oxide	165-168	interleukin 1 beta	Homo sapiens	95-103
28875725-9	2018	RESULTS: IL-1beta mRNA expression was found to possess a haplotype-dependent effect ( p = 0.0001) and its expression levels positively correlated with NOx levels ( r = 0.34; p = 0.006).	nicotine 1-N-oxide	151-154	interleukin 1 beta	Homo sapiens	9-17
28875725-0	2018	IL-1beta haplotype influences the effect of NOx exposure on gestational age in the South African MACE birth cohort.	nicotine 1-N-oxide	44-47	interleukin 1 beta	Homo sapiens	0-8
28875725-13	2018	CONCLUSION: These data have implications for better understanding the effect of prenatal NOx exposure on gestational age and demonstrate the role of the IL-1beta haplotype in modulating the effects of NOx exposure.	nicotine 1-N-oxide	201-204	interleukin 1 beta	Homo sapiens	153-161
28875725-3	2018	The aim of this study was to determine the association between the maternal interleukin-1beta (IL-1beta) haplotype and expression variation with oxides of nitrogen (NOx) levels, and thereafter investigate the IL-1beta haplotype-specific effects of NOx exposure levels, IL-1beta mRNA expression and other variables on gestational age.	Nitrogen	155-163	interleukin 1 beta	Homo sapiens	76-93
28875725-3	2018	The aim of this study was to determine the association between the maternal interleukin-1beta (IL-1beta) haplotype and expression variation with oxides of nitrogen (NOx) levels, and thereafter investigate the IL-1beta haplotype-specific effects of NOx exposure levels, IL-1beta mRNA expression and other variables on gestational age.	Nitrogen	155-163	interleukin 1 beta	Homo sapiens	95-103
28875725-3	2018	The aim of this study was to determine the association between the maternal interleukin-1beta (IL-1beta) haplotype and expression variation with oxides of nitrogen (NOx) levels, and thereafter investigate the IL-1beta haplotype-specific effects of NOx exposure levels, IL-1beta mRNA expression and other variables on gestational age.	nicotine 1-N-oxide	165-168	interleukin 1 beta	Homo sapiens	76-93
29611775-9	2018	In vitro experiments showed that lupus CD4+ T cells had more pronounced IRAK1 phosphorylation at threonine-209 upon IL-1beta stimulation than did control cells.	Threonine	97-106	interleukin 1 beta	Homo sapiens	116-124
28914997-4	2018	The purpose of this study was to examine the effects of hyaluronic acid (HA; 100 mug/mL) supplemented with AA (50 mug/mL) on human normal and interleukin-1 beta-stimulated (IL-1beta, 10 ng/mL) chondrocytes.	Hyaluronic Acid	73-75	interleukin 1 beta	Homo sapiens	173-181
29758489-0	2018	Fisetin inhibits the generation of inflammatory mediators in interleukin-1beta-induced human lung epithelial cells by suppressing the NF-kappaB and ERK1/2 pathways.	fisetin	0-7	interleukin 1 beta	Homo sapiens	61-78
29758489-2	2018	This study investigated whether fisetin can suppress the expression of inflammatory mediators and intercellular adhesion molecule 1 (ICAM-1) in A549 human lung epithelial cells that were stimulated with interleukin-1beta (IL-1beta) to induce inflammatory responses.	fisetin	32-39	interleukin 1 beta	Homo sapiens	203-220
29587166-7	2018	The fold changes of LPS-induced secretion of IL-6 and TNF-alpha from monocytes cultured for 6 and 18 h were all lower in the patient groups, and that was true for IL-1beta as monocytes cultured for 18 h. LIMITATIONS: Given the gap between the results of in vitro experiments and the actual response that happens in vivo when the immune system encounters pathogens from the external world, future research should include in vivo methods to test the results of the current study.	lps	20-23	interleukin 1 beta	Homo sapiens	163-171
29758489-7	2018	Co-treatment of IL-1beta-stimulated A549 cells with ERK1/2 inhibitors plus fisetin reduced ICAM-1 expression.	fisetin	75-82	interleukin 1 beta	Homo sapiens	16-24
29663503-10	2018	Apart from these, miR-135a can also modulate inflammation molecules including IL-6, IL-1beta, and TNF-alpha.	mir-135a	18-26	interleukin 1 beta	Homo sapiens	84-92
29962853-4	2018	The anti-inflammatory effect of alpha-bisabolol was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-1beta, and the anti-inflammatory cytokine IL-10, in pregnant human myometrial explants stimulated with lipopolysaccharide (LPS).	alpha-Bisabolol	32-47	interleukin 1 beta	Homo sapiens	165-187
29962853-7	2018	alpha-Bisabolol caused a concentration-dependent decrease in myometrial cAMP levels (p&lt;0.05) and a concentration-dependent decrease in LPS-induced TNFalpha and IL-1beta production, while IL-10 production did not increase significantly (p&gt;0.05).	alpha-Bisabolol	0-15	interleukin 1 beta	Homo sapiens	163-171
29624919-9	2018	In comparison, NL of PsA-chron patients revealed generally lower IL-8 and IL-1beta concentrations as in PsA-free patients, most likely due to a consequent antibiotic and anti-inflammatory therapy (eg, with azithromycin).	Azithromycin	206-218	interleukin 1 beta	Homo sapiens	74-82
30045312-7	2018	The pooled results showed a significant relationship between MI and IL-1beta + 3954C/T in an allelic comparison (T vs C: OR = 1.13, 95% CI 1.02-1.25, I = 0%, PH = .448) and in a dominant model (TC + TT vs CC: OR = 1.15, 95% CI 1.02-1.30, I = 0%, PH = .880).	tc + tt	194-201	interleukin 1 beta	Homo sapiens	68-76
29749448-5	2018	In addition, the expression levels of pro-inflammatory cytokines interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha were also increased following treatment with Dex-SPIONs.	dex-spions	171-181	interleukin 1 beta	Homo sapiens	65-87
30033950-6	2018	Sera from septic patients who ultimately did not survive significantly suppressed IL-1beta production only in response to extracellular ATP.	Adenosine Triphosphate	136-139	interleukin 1 beta	Homo sapiens	82-90
29107116-2	2018	Studies have demonstrated that loss of autophagy/mitophagy can lead to a build-up of cytosolic reactive oxygen species and mitochondrial DNA, which can, in turn, activate immune signalling pathways that ultimately lead to the releases of inflammatory cytokines, including IL-1alpha, IL-1beta, IL-18, type I IFN and macrophage migration inhibitory factor (MIF).	Reactive Oxygen Species	95-118	interleukin 1 beta	Homo sapiens	283-291
29891674-6	2018	A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1beta release following activation of the NLRP3 inflammasome in macrophages.	n-acetyl-phe-leu-thr-asp-chloromethylketone	27-70	interleukin 1 beta	Homo sapiens	253-261
30002661-6	2018	In addition, baricitinib inhibited Th1 differentiation after IL-12 stimulation and Th17 differentiation by TGF-beta1, IL-6, IL-1beta, and IL-23 stimulation.	baricitinib	13-24	interleukin 1 beta	Homo sapiens	124-132
29941940-8	2018	LPS + ATP increased gene expression of NRLP3 and IL1B.	Adenosine Triphosphate	6-9	interleukin 1 beta	Homo sapiens	49-53
29941940-11	2018	Moreover, LPS + ATP increased IL-1beta protein expression and production, which were prevented by glyburide.	Adenosine Triphosphate	16-19	interleukin 1 beta	Homo sapiens	30-38
29941940-11	2018	Moreover, LPS + ATP increased IL-1beta protein expression and production, which were prevented by glyburide.	Glyburide	98-107	interleukin 1 beta	Homo sapiens	30-38
29940605-9	2018	BK treatment significantly enhanced TNF-alpha, IL-1beta, and IL-6 expression levels, and these enhancements were reduced by propofol treatment in a dose-dependent manner.	Propofol	124-132	interleukin 1 beta	Homo sapiens	47-55
29932110-0	2018	DPIE [2-(1,2-diphenyl-1H-indol-3-yl)ethanamine] Augments Pro-Inflammatory Cytokine Production in IL-1beta-Stimulated Primary Human Oral Cells.	dpie	0-4	interleukin 1 beta	Homo sapiens	97-105
29932110-0	2018	DPIE [2-(1,2-diphenyl-1H-indol-3-yl)ethanamine] Augments Pro-Inflammatory Cytokine Production in IL-1beta-Stimulated Primary Human Oral Cells.	1,2-Diphenyltryptamine	6-46	interleukin 1 beta	Homo sapiens	97-105
29932110-6	2018	Of these, only (2-(1,2-diphenyl-1H-indol-3-yl)ethanamine (DPIE) showed a synergistic increase in inflammatory molecules and cytokine production (IL-6, IL-8, and COX-2) at both mRNA and protein levels in IL-1&amp;beta;-stimulated GFs.	1,2-Diphenyltryptamine	16-56	interleukin 1 beta	Homo sapiens	203-216
29932110-6	2018	Of these, only (2-(1,2-diphenyl-1H-indol-3-yl)ethanamine (DPIE) showed a synergistic increase in inflammatory molecules and cytokine production (IL-6, IL-8, and COX-2) at both mRNA and protein levels in IL-1&amp;beta;-stimulated GFs.	dpie	58-62	interleukin 1 beta	Homo sapiens	203-216
29932110-7	2018	The enhancing activity of DPIE in IL-1&amp;beta;-induced cytokine production increased in a dose-dependent manner without cytotoxicity.	dpie	26-30	interleukin 1 beta	Homo sapiens	34-47
29932110-9	2018	Furthermore, we measured the impact of DPIE on the IL-1&amp;beta;-IL-1R1 system using surface plasmon resonance and demonstrated that DPIE increased the binding affinity of IL-1&amp;beta; to IL-1R1.	dpie	39-43	interleukin 1 beta	Homo sapiens	51-64
29932110-9	2018	Furthermore, we measured the impact of DPIE on the IL-1&amp;beta;-IL-1R1 system using surface plasmon resonance and demonstrated that DPIE increased the binding affinity of IL-1&amp;beta; to IL-1R1.	dpie	39-43	interleukin 1 beta	Homo sapiens	173-186
29932110-9	2018	Furthermore, we measured the impact of DPIE on the IL-1&amp;beta;-IL-1R1 system using surface plasmon resonance and demonstrated that DPIE increased the binding affinity of IL-1&amp;beta; to IL-1R1.	dpie	134-138	interleukin 1 beta	Homo sapiens	51-64
29932110-9	2018	Furthermore, we measured the impact of DPIE on the IL-1&amp;beta;-IL-1R1 system using surface plasmon resonance and demonstrated that DPIE increased the binding affinity of IL-1&amp;beta; to IL-1R1.	dpie	134-138	interleukin 1 beta	Homo sapiens	173-186
30111029-13	2018	In addition, when BAY11-7082 was used to treat NPCs, the expression of TNF-alpha, IL-1beta, MMP-3 and MMP-13 were significantly decreased.	3-(4-methylphenylsulfonyl)-2-propenenitrile	18-28	interleukin 1 beta	Homo sapiens	82-90
29933379-9	2018	Colonic IL-1beta concentrations, colonic and systemic CD11b+ cell infiltration, and the number of migrating CD11b+ cells on colonic blood vessels were all increased in TNBS treated mice relative to controls.	Trinitrobenzenesulfonic Acid	168-172	interleukin 1 beta	Homo sapiens	8-16
29891674-6	2018	A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1beta release following activation of the NLRP3 inflammasome in macrophages.	ac-fltd	72-79	interleukin 1 beta	Homo sapiens	253-261
29983861-7	2018	Moreover, DAB and to lesser extent VEM enhanced IL-1beta (interleukin 1 beta) release by splenic DC, and by LPS-stimulated BMDC.	dabrafenib	10-13	interleukin 1 beta	Homo sapiens	48-56
29983861-7	2018	Moreover, DAB and to lesser extent VEM enhanced IL-1beta (interleukin 1 beta) release by splenic DC, and by LPS-stimulated BMDC.	dabrafenib	10-13	interleukin 1 beta	Homo sapiens	58-76
29983861-7	2018	Moreover, DAB and to lesser extent VEM enhanced IL-1beta (interleukin 1 beta) release by splenic DC, and by LPS-stimulated BMDC.	Vemurafenib	35-38	interleukin 1 beta	Homo sapiens	48-56
29983861-7	2018	Moreover, DAB and to lesser extent VEM enhanced IL-1beta (interleukin 1 beta) release by splenic DC, and by LPS-stimulated BMDC.	Vemurafenib	35-38	interleukin 1 beta	Homo sapiens	58-76
29983861-11	2018	Immunomodulatory activity of DAB and VEM was also observed in human monocyte-derived DC, and DAB induced IL-1beta in human primary DC.	dabrafenib	93-96	interleukin 1 beta	Homo sapiens	105-113
29898779-0	2018	Melatonin rescued interleukin 1beta-impaired chondrogenesis of human mesenchymal stem cells.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	18-35
29914535-5	2018	RESULTS: After the bone cut and surgery, TXA significantly increased MCP-1, TNF-alpha, IL-1beta and IL-6 levels compared to non-TXA patients, which was further amplified postoperatively.	Tranexamic Acid	41-44	interleukin 1 beta	Homo sapiens	87-95
30013439-13	2018	Release of cytokines IL-1beta, IL-6, IL-10 and TNFalpha was induced by silica exposure and the induction of IL-1beta, IL-6 and TNFalpha was suppressed by the addition of TAK-242.	Silicon Dioxide	71-77	interleukin 1 beta	Homo sapiens	21-29
29596892-13	2018	In conclusion, the cholesterol sensor SCAP plays a role in regulating the expression of inflammatory factors such as IL-1beta, TNF-alpha, and MCP-1 in THP-1 macrophages.	Cholesterol	19-30	interleukin 1 beta	Homo sapiens	117-125
29775050-3	2018	The surface-functionalized PU NPs decrease the secretion levels of proinflammatory cytokines (TNF-alpha and IL-1beta) for M1 macrophages.	Plutonium	27-29	interleukin 1 beta	Homo sapiens	108-116
29895944-10	2018	The ELISA results suggested that the concentration of interleukin-1 beta (IL-1beta) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis.	icariin	91-98	interleukin 1 beta	Homo sapiens	54-72
29895944-10	2018	The ELISA results suggested that the concentration of interleukin-1 beta (IL-1beta) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis.	icariin	91-98	interleukin 1 beta	Homo sapiens	74-82
29895944-10	2018	The ELISA results suggested that the concentration of interleukin-1 beta (IL-1beta) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis.	Sodium Chloride	144-148	interleukin 1 beta	Homo sapiens	54-72
29895944-10	2018	The ELISA results suggested that the concentration of interleukin-1 beta (IL-1beta) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis.	Sodium Chloride	144-148	interleukin 1 beta	Homo sapiens	74-82
29895944-10	2018	The ELISA results suggested that the concentration of interleukin-1 beta (IL-1beta) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis.	icariin	196-203	interleukin 1 beta	Homo sapiens	54-72
29895944-10	2018	The ELISA results suggested that the concentration of interleukin-1 beta (IL-1beta) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis.	icariin	196-203	interleukin 1 beta	Homo sapiens	74-82
29573646-8	2018	CONCLUSIONS: In this study, the differences of oxidative status and IL-1beta levels during RME treatment could be attributable to orthopedic effect of the heavy forces on maxilla and minimal orthodontic forces on teeth applied by the RME apparatus.	3-Pyridinecarboxamide, N-ethyl-2-(4-methyl-1-piperazinyl)-	91-94	interleukin 1 beta	Homo sapiens	68-76
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	67-82	interleukin 1 beta	Homo sapiens	240-248
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	84-88	interleukin 1 beta	Homo sapiens	240-248
29446321-4	2018	To induce IL-1beta expression in the pulmonary epithelium of mice with a tetracycline-inducible human IL-1beta transgene, doxycycline was administered via intraperitoneal injections to bitransgenic pups and their littermate controls on postnatal days (PN) 0, 0.5, and 1.	Tetracycline	73-85	interleukin 1 beta	Homo sapiens	102-110
29446321-4	2018	To induce IL-1beta expression in the pulmonary epithelium of mice with a tetracycline-inducible human IL-1beta transgene, doxycycline was administered via intraperitoneal injections to bitransgenic pups and their littermate controls on postnatal days (PN) 0, 0.5, and 1.	Doxycycline	122-133	interleukin 1 beta	Homo sapiens	102-110
29573646-8	2018	CONCLUSIONS: In this study, the differences of oxidative status and IL-1beta levels during RME treatment could be attributable to orthopedic effect of the heavy forces on maxilla and minimal orthodontic forces on teeth applied by the RME apparatus.	3-Pyridinecarboxamide, N-ethyl-2-(4-methyl-1-piperazinyl)-	234-237	interleukin 1 beta	Homo sapiens	68-76
29710527-6	2018	Our results indicate that sodium butyrate significantly abrogated IL-1beta-induced up-regulation of MMP-1, MMP-3, and MMP-13 at both the gene and protein levels.	Butyric Acid	26-41	interleukin 1 beta	Homo sapiens	66-74
29342502-10	2018	Indeed, anti-beta2 GPI aPL inhibited basal trophoblast autophagy, and reversing this with rapamycin inhibited aPL-induced inflammasome function and IL-1beta secretion.	Sirolimus	90-99	interleukin 1 beta	Homo sapiens	148-156
28595461-5	2018	The Chr-blended PCL/PEG nanofibrous mats also reduced overexpression of IL-6, IL-1beta, TNF-alpha and excessive production of nitric oxide (NO) in J774A1 following stimulation by lipopolysaccharide (LPS).	Polyethylene Glycols	20-23	interleukin 1 beta	Homo sapiens	78-86
29710527-5	2018	In the current study, for the first time, we aimed to determine whether sodium butyrate influences IL-1beta-induced degradation of type II collagen in human chondrocytes in the articular cartilage matrix.	Butyric Acid	72-87	interleukin 1 beta	Homo sapiens	99-107
29710527-8	2018	Notably, sodium butyrate attenuated IL-1beta-induced degradation of type II collagen.	Butyric Acid	9-24	interleukin 1 beta	Homo sapiens	36-44
29754770-4	2018	We characterized the phenotype and the function of DCs matured in the presence of sulprostone as a potential substitute of dinoprostone in the pro-inflammatory maturation cocktail consisting of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and IL-6.	sulprostone	82-93	interleukin 1 beta	Homo sapiens	235-253
29525626-0	2018	Effects on IL-1beta signaling activation induced by water and organic extracts of fine particulate matter (PM2.5) in vitro.	Water	52-57	interleukin 1 beta	Homo sapiens	11-19
29525626-6	2018	The inhibition of signaling molecules suggested that increased IL-1beta was associated with the TLR4/NF-kappaB pathway and NLRP3 inflammasome activation, with a slightly difference between water and organic extracts exposure groups, which was likely the result of different chemical components.	Water	189-194	interleukin 1 beta	Homo sapiens	63-71
29904429-11	2018	Propofol partly inhibited inflammatory cytokine production, including IL-1beta and IL-6, and the anti-inflammatory effect may result from inhibition of JNK-MAPK, and enhanced NF-kappaB and extracellular signal-regulated kinase-MAPK signaling at clinical concentrations.	Propofol	0-8	interleukin 1 beta	Homo sapiens	70-78
29608374-17	2018	Serum IL-1beta, IL-6, and TNF-alpha were higher in the AMS group than in the non-AMS group.	ams	55-58	interleukin 1 beta	Homo sapiens	6-14
29608374-20	2018	CONCLUSIONS: Acute phase proteins and inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) show significant changes between the AMS group and the non-AMS group.	ams	130-133	interleukin 1 beta	Homo sapiens	62-70
29608374-20	2018	CONCLUSIONS: Acute phase proteins and inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) show significant changes between the AMS group and the non-AMS group.	ams	152-155	interleukin 1 beta	Homo sapiens	62-70
29704732-3	2018	Paeonol pretreatment showed statistically significant reduction in alcohol-induced ROS, MDA, IL-1beta, IL-6, TNF-alpha, and nitric oxide, while GSH content was retained (P &lt; 0.05).	paeonol	0-7	interleukin 1 beta	Homo sapiens	93-101
29759006-11	2018	In this regard, the ongoing trials with methotrexate and colchicine may clarify whether the cardiovascular benefit of IL-1beta blockade extends to other anti-inflammatory mechanisms.	Methotrexate	40-52	interleukin 1 beta	Homo sapiens	118-126
29759006-11	2018	In this regard, the ongoing trials with methotrexate and colchicine may clarify whether the cardiovascular benefit of IL-1beta blockade extends to other anti-inflammatory mechanisms.	Colchicine	57-67	interleukin 1 beta	Homo sapiens	118-126
30938266-8	2018	However, a minority of FMF patients are colchicine-resistant, and anti-IL-1 treatment has proven beneficial in suppressing inflammation in these patients.	Colchicine	40-50	interleukin 1 beta	Homo sapiens	71-75
29349683-5	2018	PMS (20 and 40 mug/ml) decreased the expression levels of MUC5AC, IL-6, and IL-1beta, which were induced by LPS treatment.	plantamajoside	0-3	interleukin 1 beta	Homo sapiens	76-84
29754770-4	2018	We characterized the phenotype and the function of DCs matured in the presence of sulprostone as a potential substitute of dinoprostone in the pro-inflammatory maturation cocktail consisting of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and IL-6.	sulprostone	82-93	interleukin 1 beta	Homo sapiens	255-263
29636364-5	2018	In stromal cells of endometriotic lesions, bufalin treatment increased the levels of pyroptosis markers (caspase 1 and the active form of interleukin 1beta) and reduced proliferation.	bufalin	43-50	interleukin 1 beta	Homo sapiens	138-155
29656207-5	2018	The results demonstrated that the increased expression levels of interleukin-1beta (IL-1beta), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-alpha) were significantly inhibited by DMY.	dihydromyricetin	188-191	interleukin 1 beta	Homo sapiens	65-82
29656207-5	2018	The results demonstrated that the increased expression levels of interleukin-1beta (IL-1beta), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-alpha) were significantly inhibited by DMY.	dihydromyricetin	188-191	interleukin 1 beta	Homo sapiens	84-92
29947343-4	2018	METHODS: AIM2 expression was analyzed by flow cytometry, it"s activity was assessed by measuring in vitro release of IL-1beta induced by Poly (dA:dT), and mtDNA copy number was determined by quantitative real-time polymerase chain reaction.	poly	137-141	interleukin 1 beta	Homo sapiens	117-125
29960844-7	2018	Pretreatment with salidroside markedly inhibited the production levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in a dose-dependent manner.	rhodioloside	18-29	interleukin 1 beta	Homo sapiens	115-132
29492971-9	2018	AA, DHA and EPA counteracted IL-1beta-mediated increases in P-GP activity, while AA and EPA, but not DHA, counteracted glucocorticoid-mediated increase in P-GP activity.	Docosahexaenoic Acids	4-7	interleukin 1 beta	Homo sapiens	29-37
29492971-9	2018	AA, DHA and EPA counteracted IL-1beta-mediated increases in P-GP activity, while AA and EPA, but not DHA, counteracted glucocorticoid-mediated increase in P-GP activity.	Eicosapentaenoic Acid	12-15	interleukin 1 beta	Homo sapiens	29-37
29960844-7	2018	Pretreatment with salidroside markedly inhibited the production levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in a dose-dependent manner.	rhodioloside	18-29	interleukin 1 beta	Homo sapiens	134-142
29475133-9	2018	These results suggest that mitochondrial ROS-TXNIP/NLRP3/IL-1beta axis activation is responsible for tubular oxidative injury, which can be ameliorated by MitoQ via the inhibition of mtROS overproduction.	mitoquinone	155-160	interleukin 1 beta	Homo sapiens	57-65
29164820-3	2018	METHODS &amp; RESULTS: HepG2 cells treated with palmitic acid (PA;0.75 mM) showed decreased expression of various antioxidant biomarkers (SOD1, SOD2, glutathione peroxidase and catalase) and increased expression of inflammatory markers (TNFalpha, IL1beta and IL6).	Palmitic Acid	48-61	interleukin 1 beta	Homo sapiens	247-254
29164820-3	2018	METHODS &amp; RESULTS: HepG2 cells treated with palmitic acid (PA;0.75 mM) showed decreased expression of various antioxidant biomarkers (SOD1, SOD2, glutathione peroxidase and catalase) and increased expression of inflammatory markers (TNFalpha, IL1beta and IL6).	Protactinium	63-65	interleukin 1 beta	Homo sapiens	247-254
28587487-9	2018	Dianosides M-N increased IL-1beta concentration significantly whereas the n-butanol fraction slightly augmented IL-1beta secretion.	1-Butanol	74-83	interleukin 1 beta	Homo sapiens	112-120
29510342-4	2018	While bacterial cell counts decrease due to dHL-60 killing, incubation with uric acid inhibits this activity, also decreasing the release of the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF- alpha).	Uric Acid	76-85	interleukin 1 beta	Homo sapiens	168-185
29510342-4	2018	While bacterial cell counts decrease due to dHL-60 killing, incubation with uric acid inhibits this activity, also decreasing the release of the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF- alpha).	Uric Acid	76-85	interleukin 1 beta	Homo sapiens	187-195
29658572-11	2018	PKR activation with rotenone (10 microM) abrogated endotoxin tolerance by increasing the levels of the IL-1beta, CCL17 and CCL22 mRNAs and decreasing the levels of the Arg1 and iNOS mRNAs.	Rotenone	20-28	interleukin 1 beta	Homo sapiens	103-111
28437591-0	2018	Fluorofenidone attenuates interleukin-1beta production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	0-14	interleukin 1 beta	Homo sapiens	26-43
28437591-1	2018	AIM: We explored whether Fluorofenidone reduced interleukin-1beta (IL-1beta) production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction (UUO).	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	25-39	interleukin 1 beta	Homo sapiens	48-65
28437591-1	2018	AIM: We explored whether Fluorofenidone reduced interleukin-1beta (IL-1beta) production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction (UUO).	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	25-39	interleukin 1 beta	Homo sapiens	67-75
28437591-9	2018	Interestingly, Fluorofenidone inhibited the activation of NLRP3 inflammasome, downregulated Caspase-1 levels and thereby decreased the cleavage of pro-IL-1beta into IL-1beta in vivo and in vitro.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	15-29	interleukin 1 beta	Homo sapiens	147-159
28437591-9	2018	Interestingly, Fluorofenidone inhibited the activation of NLRP3 inflammasome, downregulated Caspase-1 levels and thereby decreased the cleavage of pro-IL-1beta into IL-1beta in vivo and in vitro.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	15-29	interleukin 1 beta	Homo sapiens	151-159
28437591-12	2018	CONCLUSION: Fluorofenidone serves as a novel anti-inflammatory agent that attenuates IL-1beta production in UUO model by interacting with NLRP3 inflammasome.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	12-26	interleukin 1 beta	Homo sapiens	85-93
29475133-7	2018	Treating HK-2 cells with MitoQ suppressed the dissociation of TRX from TXNIP and subsequently blocked the interaction between TXNIP and NLRP3, leading to the inhibition of NLRP3 inflammasome activation and IL-1beta maturation.	mitoquinone	25-30	interleukin 1 beta	Homo sapiens	206-214
29475133-9	2018	These results suggest that mitochondrial ROS-TXNIP/NLRP3/IL-1beta axis activation is responsible for tubular oxidative injury, which can be ameliorated by MitoQ via the inhibition of mtROS overproduction.	Reactive Oxygen Species	41-44	interleukin 1 beta	Homo sapiens	57-65
29477863-7	2018	These divergences in ROS production seem to be correlated with the different extension of intracellular signaling pathways activation and, by consequence, with distinct transcription kinetics of genes such as HMOX1, IL8, IL1B and CD86.	Reactive Oxygen Species	21-24	interleukin 1 beta	Homo sapiens	221-225
29518228-5	2018	We here demonstrate that the maturation and secretion of IL-1beta during ZIKV infection was mediated by NLRP3 inflammasome activation and that ZIKV nonstructural protein 5 (NS5) facilitated the assembly of the NLRP3 inflammasome complex, leading to IL-1beta activation through interaction with NLRP3 and induction of reactive oxygen species production.	Reactive Oxygen Species	317-340	interleukin 1 beta	Homo sapiens	57-65
29484768-10	2018	High-d-glucose treatment significantly reduced MACs proangiogenic capacity, which was associated with a significant increase in IL1beta mRNA and protein expression.	Glucose	7-14	interleukin 1 beta	Homo sapiens	128-135
29484768-11	2018	Inhibition of IL1beta abrogated the antiangiogenic effect induced by high-d-glucose.	Glucose	74-83	interleukin 1 beta	Homo sapiens	14-21
29484768-13	2018	This study demonstrates that Type 1 diabetes and diabetic-like conditions impair the proangiogenic and regenerative capacity of MACs, and this response is mediated by IL-1beta.	macs	128-132	interleukin 1 beta	Homo sapiens	167-175
29524120-4	2018	The discovery of the role of interleukin-1beta (IL-1beta) in orchestrating the monosodium urate crystal-induced inflammatory response offered new therapeutic prospects to refractory patients, or to those in whom standard therapies are contraindicated.	Uric Acid	79-95	interleukin 1 beta	Homo sapiens	29-46
29524120-4	2018	The discovery of the role of interleukin-1beta (IL-1beta) in orchestrating the monosodium urate crystal-induced inflammatory response offered new therapeutic prospects to refractory patients, or to those in whom standard therapies are contraindicated.	Uric Acid	79-95	interleukin 1 beta	Homo sapiens	48-56
29748238-6	2018	Overexpression of miR-302e blocked PMA/A23187 or OVA induced the increase in inflammatory cytokines levels, such as IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha and thymic stromal lymphopoietin, while miR-302 inhibition further promoted the release of these cytokines.	Calcimycin	39-45	interleukin 1 beta	Homo sapiens	116-124
29868030-3	2018	Cyclic dinucleotides recognition enables classical dendritic cells (cDCs) that predominantly express CD103 to induce Th17 lymphocytes in an IL-6/IL-1beta-dependent manner in gut.	cyclic dinucleotides	0-20	interleukin 1 beta	Homo sapiens	145-153
29795378-6	2018	Interestingly, we found that the increased autophagic flux observed in macrophages infected with modern MTBC is due to an autocrine activity of the proinflammatory cytokine IL-1beta, since autophagosome maturation is blocked by an interleukin-1 receptor antagonist.	mtbc	104-108	interleukin 1 beta	Homo sapiens	173-181
29784003-8	2018	I-BET151 could robustly suppress the IL-1beta- and TNF-alpha-induced expression and activity of several matrix-degrading enzymes in human chondrocytes.	GSK1210151A	0-8	interleukin 1 beta	Homo sapiens	37-45
29772789-6	2018	Moreover, it enhanced the expression of aquaporin 1, which is an important water channel that is expressed in the proximal tubules, and reverted aquaporin 1 downregulation induced by IL-1beta/TNFalpha.	Water	75-80	interleukin 1 beta	Homo sapiens	183-191
29706079-8	2018	TAX downregulated IL-1beta cleavage responses to LPS and ATP stimulation in HepG2 cells.	Adenosine Triphosphate	57-60	interleukin 1 beta	Homo sapiens	18-26
29724886-9	2018	We discovered that the expression of the factors was significantly increased in pterygium and that caspase-1-dependent pyroptosis presents in both H2O2-treated HPFs and HConECs during which the expression of these factors was significantly elevated and the elevation of downstream factors IL-18 and IL-1beta was restrained after caspase-1 inhibition.	Hydrogen Peroxide	147-151	interleukin 1 beta	Homo sapiens	299-307
29771935-7	2018	Further, iron loading of macrophages prevented the pro-inflammatory response induced by LPS through reduction of NF-kappaB p65 nuclear translocation with decreased iNOS, IL-1beta, IL-6, IL-12 and TNFalpha expression.	Iron	9-13	interleukin 1 beta	Homo sapiens	170-178
29785126-14	2018	In the whole-blood culture model, the cytokines with the most pronounced increase after OT-101 treatment were IL-1beta, IL-8, and MCP-1.	ot-101	88-94	interleukin 1 beta	Homo sapiens	110-118
29768427-0	2018	Differential effects of TNF-alpha and IL-1beta on the control of metal metabolism and cadmium-induced cell death in chronic inflammation.	Metals	65-70	interleukin 1 beta	Homo sapiens	38-46
29768427-0	2018	Differential effects of TNF-alpha and IL-1beta on the control of metal metabolism and cadmium-induced cell death in chronic inflammation.	Cadmium	86-93	interleukin 1 beta	Homo sapiens	38-46
29768427-4	2018	The aim of this work was to evaluate if IL-1beta interaction with IL-17 also contributes to metal-import mechanisms and its effects on cell viability and inflammation.	Metals	92-97	interleukin 1 beta	Homo sapiens	40-48
29768427-8	2018	Metal import was lower with IL17/ IL-1beta in comparison to IL-17/TNF-alpha exposed-synoviocytes, as the expression of ZIP-8 and MT-1F was less induced.	Metals	0-5	interleukin 1 beta	Homo sapiens	34-42
29768427-9	2018	Monocyte and PBMCs exposure to Cd resulted in a reduced production of IL-1beta and an increased production of TNF-alpha and this result was confirmed in co-cultures of synoviocytes and PBMCs.	Cadmium	31-33	interleukin 1 beta	Homo sapiens	70-78
29768427-10	2018	The IL-17/IL-1beta combination with Cd slightly reduced cell viability in comparison to the IL-17/TNF-alpha combination and resulted in a strong induction of IL-6 production.	Cadmium	36-38	interleukin 1 beta	Homo sapiens	10-18
30701884-4	2018	The mechanisms of atherosclerosis associated with IL-1beta determine the ability of cholesterol crystals and other "Pro-atherogenic" factors to induce the synthesis of IL-1beta by activating NLRP3 inflammasome.	Cholesterol	84-95	interleukin 1 beta	Homo sapiens	50-58
29649742-6	2018	In contrast to the quinolinone derivatives, the antagonistic effects of the quinoline compounds (16c and 17k) were paralleled by their ability to inhibit the release of the pro-inflammatory cytokine, IL-1beta, from LPS/IFN-gamma/BzATP-stimulated THP-1 cells (IC50 of 7 and 12 nM, respectively).	quinoline	76-85	interleukin 1 beta	Homo sapiens	200-208
29649742-6	2018	In contrast to the quinolinone derivatives, the antagonistic effects of the quinoline compounds (16c and 17k) were paralleled by their ability to inhibit the release of the pro-inflammatory cytokine, IL-1beta, from LPS/IFN-gamma/BzATP-stimulated THP-1 cells (IC50 of 7 and 12 nM, respectively).	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	229-234	interleukin 1 beta	Homo sapiens	200-208
29649742-4	2018	However, because most of the quinolinone derivatives showed low inhibitory effects in an IL-1beta ELISA assay, the core structure was further modified to a quinoline skeleton with chloride or substituted phenyl groups.	Quinolones	29-40	interleukin 1 beta	Homo sapiens	89-97
29649742-4	2018	However, because most of the quinolinone derivatives showed low inhibitory effects in an IL-1beta ELISA assay, the core structure was further modified to a quinoline skeleton with chloride or substituted phenyl groups.	quinoline	156-165	interleukin 1 beta	Homo sapiens	89-97
30701884-4	2018	The mechanisms of atherosclerosis associated with IL-1beta determine the ability of cholesterol crystals and other "Pro-atherogenic" factors to induce the synthesis of IL-1beta by activating NLRP3 inflammasome.	Cholesterol	84-95	interleukin 1 beta	Homo sapiens	168-176
30701884-5	2018	The mechanisms of atherosclerosis associated with IL-1beta determine the ability of cholesterol crystals and other "proatherogenic" factors to induce the synthesis of IL-1beta by activating NLRP3 inflammasome.	Cholesterol	84-95	interleukin 1 beta	Homo sapiens	50-58
30701884-5	2018	The mechanisms of atherosclerosis associated with IL-1beta determine the ability of cholesterol crystals and other "proatherogenic" factors to induce the synthesis of IL-1beta by activating NLRP3 inflammasome.	Cholesterol	84-95	interleukin 1 beta	Homo sapiens	167-175
29683320-4	2018	KCO-4 inhibited the oversecretion of inflammatory mediators (i.e., NO, TNF-alpha, IL-1beta, IL-8, iNOS, and COX-2).	kco-4	0-5	interleukin 1 beta	Homo sapiens	82-90
29549113-4	2018	CDD-450 had no effect on NLRP3 expression, but it decreased IL-1beta expression by promoting IL-1beta mRNA degradation.	zunsemetinib	0-7	interleukin 1 beta	Homo sapiens	60-68
29549113-4	2018	CDD-450 had no effect on NLRP3 expression, but it decreased IL-1beta expression by promoting IL-1beta mRNA degradation.	zunsemetinib	0-7	interleukin 1 beta	Homo sapiens	93-101
29668284-8	2018	HCQ pretreatment caused a significant decrease of TNF-alpha and MCP-1 secretion and an increase of IL-1beta and CXCL10 release from UC-MSCs.	Hydroxychloroquine	0-3	interleukin 1 beta	Homo sapiens	99-107
28835131-0	2018	IL-1beta and TNFalpha inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids.	Fatty Acids, Omega-3	191-206	interleukin 1 beta	Homo sapiens	0-8
29743895-6	2018	In addition, treatment with 50 and 100 muM osthole for 48 h inhibited 10 ng/ml IL-1beta-stimulated proliferation and migration of SW982, and significantly inhibited the expression of matrix metalloproteinases, such as MMP-1, MMP-3 and MMP-13, as detected by western blot.	osthol	43-50	interleukin 1 beta	Homo sapiens	79-87
29743895-7	2018	50 and 100 muM osthole also blocked the generation of IL-6 and TNF-alpha in IL-1beta-stimulated SW982 cells.	osthol	15-22	interleukin 1 beta	Homo sapiens	76-84
29743895-8	2018	The NF-kappaB and MAPK pathways were also inhibited by osthole in IL-1beta-treated SW982 cells.	osthol	55-62	interleukin 1 beta	Homo sapiens	66-74
29431121-6	2018	RESULTS: MTX conditioned macrophages towards a tolerant state, diminishing interleukin (IL)-6 and IL-1beta production in LPS, LTA, TNFalpha or RASF-challenged macrophages.	Methotrexate	9-12	interleukin 1 beta	Homo sapiens	98-106
29716544-4	2018	Immunohistochemistry was used to examine the expression of NLRP3 and IL-1beta in the paraffin-embedded OSCC tissues.	Paraffin	85-93	interleukin 1 beta	Homo sapiens	69-77
29716544-9	2018	Obvious expression of NLRP3 and IL-1beta was found in the paraffin-embedded OSCC tissues, and the NLRP3 expression levels were correlated with the tumor size, lymphonode metastatic status and IL-1beta expression.	Paraffin	58-66	interleukin 1 beta	Homo sapiens	32-40
28835131-7	2018	DHA slightly countered the actions of IL-1beta on CCL2, IL6 and ADIPOQ expression, though not on secretion of these adipokines.	Docosahexaenoic Acids	0-3	interleukin 1 beta	Homo sapiens	38-46
29584621-5	2018	This mitochondrial source of ROS contributes to NF-kappaB-driven production of IL-1beta and TNF-alpha, which promote neutrophil recruitment.	ros	29-32	interleukin 1 beta	Homo sapiens	79-87
28357449-10	2018	RESULTS: The results showed that myricetin blunted the overexpression of IL-1beta, IL-6, and TNF-alpha markedly by inhibiting the NF-kappaB/P65 signaling pathway.	myricetin	33-42	interleukin 1 beta	Homo sapiens	73-81
29587203-4	2018	We found that high glucose induced phosphorylation of Btk, MAPKs and NF-kappaB, and the expression of downstream inflammation cytokines monocyte chemo-attractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Glucose	19-26	interleukin 1 beta	Homo sapiens	225-242
29587203-4	2018	We found that high glucose induced phosphorylation of Btk, MAPKs and NF-kappaB, and the expression of downstream inflammation cytokines monocyte chemo-attractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Glucose	19-26	interleukin 1 beta	Homo sapiens	244-252
29338075-8	2018	Suppression of P2X7 receptor-NLRP3 activation by gentiopicroside inhibited IL-1beta production.	gentiopicroside	49-64	interleukin 1 beta	Homo sapiens	75-83
28880687-0	2018	TNF-alpha potentiates uric acid-induced interleukin-1beta (IL-1beta) secretion in human neutrophils.	Uric Acid	22-31	interleukin 1 beta	Homo sapiens	40-57
29549805-1	2018	Caspase-1 is a key endoprotease responsible for the post-translational processing of pro-inflammatory cytokines IL-1beta, 18 &amp; 33.	Adenosine Monophosphate	126-129	interleukin 1 beta	Homo sapiens	112-120
28880687-0	2018	TNF-alpha potentiates uric acid-induced interleukin-1beta (IL-1beta) secretion in human neutrophils.	Uric Acid	22-31	interleukin 1 beta	Homo sapiens	59-67
28880687-1	2018	OBJECTIVE: Monosodium urate (MSU) has been shown to promote interleukin-1beta (IL-1beta) secretion in human monocytes, but the priming signals for NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway remains elusive.	Uric Acid	11-27	interleukin 1 beta	Homo sapiens	60-77
28880687-1	2018	OBJECTIVE: Monosodium urate (MSU) has been shown to promote interleukin-1beta (IL-1beta) secretion in human monocytes, but the priming signals for NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway remains elusive.	Uric Acid	11-27	interleukin 1 beta	Homo sapiens	79-87
28880687-9	2018	CONCLUSION: Our data demonstrate that priming of human neutrophils with TNF-alpha promotes uric acid-mediated IL-1beta secretion in the absence of microbial stimulation.	Uric Acid	91-100	interleukin 1 beta	Homo sapiens	110-118
29715306-11	2018	(PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6.	Dexamethasone	5-8	interleukin 1 beta	Homo sapiens	103-111
29251705-9	2018	RESULTS: Our in vitro data show that ASC treatment imparted reduced cell death (ratio to control: 1.21 +- 0.066 vs. 1.01 +- 0.056, p = 0.017), increased cell viability (ratio to control: 0.86 +- 0.009 vs. 1.09 +- 0.01, p = 0.0001), increased mitochondrial function (percentage of control: 78 +- 6% vs. 68 +- 3%), and significantly decreased levels of inflammatory cytokine IL-1beta.	asc	37-40	interleukin 1 beta	Homo sapiens	373-381
29532895-5	2018	The benzoxazole derivatives significantly reduced the expression of interleukin (IL)-1beta, IL-6, IL-13, tumor necrosis factor-alpha, perilipin (PLIN) 2, and PLIN3 in BMMCs treated with LPS.	Benzoxazoles	4-15	interleukin 1 beta	Homo sapiens	68-90
29735869-0	2018	Effects of a cyclic NSAID regimen on levels of gingival crevicular fluid prostaglandin E2and Interleukin-1beta: A 6-month randomized controlled clinical trial.	prostaglandin e2and	73-92	interleukin 1 beta	Homo sapiens	93-110
29575797-6	2018	RESULT: NTHi induced production of large amounts of IL-1beta, IL-6, and IL-8 in adult-control BAL cells, however BAL cells from PBB airways appeared refractory to NTHi stimulation.	nthi	8-12	interleukin 1 beta	Homo sapiens	52-60
29715306-9	2018	DEX inhibited IL-10 in newborn, and TNF, IL-1beta, IL-6 and interferon-alpha in newborn and adult blood.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	41-49
29715306-10	2018	AZI inhibited R848-induced TNF, IL-1beta, IL-6 and IL-10, and LPS-induced IL-1beta and IL-10.	Azithromycin	0-3	interleukin 1 beta	Homo sapiens	32-40
29715306-10	2018	AZI inhibited R848-induced TNF, IL-1beta, IL-6 and IL-10, and LPS-induced IL-1beta and IL-10.	Azithromycin	0-3	interleukin 1 beta	Homo sapiens	74-82
29715306-11	2018	(PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6.	Pentoxifylline	1-4	interleukin 1 beta	Homo sapiens	66-74
29715306-11	2018	(PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6.	Pentoxifylline	1-4	interleukin 1 beta	Homo sapiens	103-111
29306989-0	2018	Kynurenine is correlated with IL-1beta in plasma of schizophrenia patients.	Kynurenine	0-10	interleukin 1 beta	Homo sapiens	30-38
29685624-4	2018	Our results indicated that supplementation with folic acid significantly reduced the levels of interleukin-1beta and tumor necrosis factor-alpha in hypoxic conditions.	Folic Acid	48-58	interleukin 1 beta	Homo sapiens	95-144
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	16-30	interleukin 1 beta	Homo sapiens	68-85
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	16-30	interleukin 1 beta	Homo sapiens	87-95
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	169-183	interleukin 1 beta	Homo sapiens	68-85
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	169-183	interleukin 1 beta	Homo sapiens	87-95
29735019-6	2018	RESULTS: EPA+DHA therapy had a significant lowering effect on levels of IL-6, IL-1beta and TNF-alpha after 4 weeks of therapy and an even greater lowering effect after 8 weeks of therapy.	Eicosapentaenoic Acid	9-12	interleukin 1 beta	Homo sapiens	78-86
29735019-6	2018	RESULTS: EPA+DHA therapy had a significant lowering effect on levels of IL-6, IL-1beta and TNF-alpha after 4 weeks of therapy and an even greater lowering effect after 8 weeks of therapy.	Docosahexaenoic Acids	13-16	interleukin 1 beta	Homo sapiens	78-86
29715306-11	2018	(PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6.	Pentoxifylline	1-4	interleukin 1 beta	Homo sapiens	103-111
29715306-11	2018	(PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6.	Adenosine Triphosphate	49-52	interleukin 1 beta	Homo sapiens	66-74
29740988-6	2018	RESULTS: Contrary to high-dose ethanol, acute low-dose ethanol exposure significantly reduced IL-1beta-induced IL-6 and IL-6-induced IL-1beta release (P&lt;0.05).	Ethanol	55-62	interleukin 1 beta	Homo sapiens	94-102
29715306-11	2018	(PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6.	Dexamethasone	5-8	interleukin 1 beta	Homo sapiens	66-74
29715306-11	2018	(PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6.	Dexamethasone	5-8	interleukin 1 beta	Homo sapiens	103-111
29740988-6	2018	RESULTS: Contrary to high-dose ethanol, acute low-dose ethanol exposure significantly reduced IL-1beta-induced IL-6 and IL-6-induced IL-1beta release (P&lt;0.05).	Ethanol	55-62	interleukin 1 beta	Homo sapiens	133-141
29664082-5	2018	GSOUF skewed the monocyte plasticity towards the anti-inflammatory non-classical CD14+CD16++ monocytes and reduced the inflammatory competence of LPS-treated human primary monocytes diminishing TNF-alpha, IL-1beta, and IL-6 gene expression and secretion.	gsouf	0-5	interleukin 1 beta	Homo sapiens	205-213
29712570-0	2018	IL-1beta suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.	Ceramides	90-98	interleukin 1 beta	Homo sapiens	0-8
29712570-3	2018	METHODS: This study uses an in vitro approach in primary hippocampal neurons to evaluate the effect of IL-1beta on chemical LTP (cLTP)-induced structural plasticity and signaling.	cltp	129-133	interleukin 1 beta	Homo sapiens	103-111
29712570-4	2018	RESULTS: We found that IL-1beta reduces both the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 and the spine growth following cLTP.	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic	71-122	interleukin 1 beta	Homo sapiens	23-31
29712570-4	2018	RESULTS: We found that IL-1beta reduces both the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 and the spine growth following cLTP.	cltp	189-193	interleukin 1 beta	Homo sapiens	23-31
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	cltp	81-85	interleukin 1 beta	Homo sapiens	17-25
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	cltp	81-85	interleukin 1 beta	Homo sapiens	90-98
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	cltp	81-85	interleukin 1 beta	Homo sapiens	90-98
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	cltp	113-117	interleukin 1 beta	Homo sapiens	17-25
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	cltp	113-117	interleukin 1 beta	Homo sapiens	90-98
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	cltp	113-117	interleukin 1 beta	Homo sapiens	90-98
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	cltp	113-117	interleukin 1 beta	Homo sapiens	17-25
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	cltp	113-117	interleukin 1 beta	Homo sapiens	90-98
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	cltp	113-117	interleukin 1 beta	Homo sapiens	90-98
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	jasplakinolide	326-340	interleukin 1 beta	Homo sapiens	17-25
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	jasplakinolide	326-340	interleukin 1 beta	Homo sapiens	90-98
29712570-5	2018	These effects of IL-1beta were mediated by impairing actin polymerization during cLTP, as IL-1beta decreased the cLTP-induced formation of F-actin, and the effect of IL-1beta on cLTP-induced surface expression of GluA1 can be mimicked by latrunculin, a toxin that disrupts dynamics of actin filaments, and can be prevented by jasplakinolide, a cell-permeable peptide that stabilizes F-actin.	jasplakinolide	326-340	interleukin 1 beta	Homo sapiens	90-98
29712570-7	2018	We further examined the role of sphingolipid signaling in the IL-1beta-mediated impairment of spine plasticity and found that both the neutral sphingomyelinase inhibitor GW4869 and the inhibitor of Src kinase PP2 attenuated the IL-1beta-mediated suppression of cLTP-induced surface expression of GluA1 and actin polymerization.	Sphingolipids	32-44	interleukin 1 beta	Homo sapiens	62-70
29712570-7	2018	We further examined the role of sphingolipid signaling in the IL-1beta-mediated impairment of spine plasticity and found that both the neutral sphingomyelinase inhibitor GW4869 and the inhibitor of Src kinase PP2 attenuated the IL-1beta-mediated suppression of cLTP-induced surface expression of GluA1 and actin polymerization.	Sphingolipids	32-44	interleukin 1 beta	Homo sapiens	228-236
29712570-7	2018	We further examined the role of sphingolipid signaling in the IL-1beta-mediated impairment of spine plasticity and found that both the neutral sphingomyelinase inhibitor GW4869 and the inhibitor of Src kinase PP2 attenuated the IL-1beta-mediated suppression of cLTP-induced surface expression of GluA1 and actin polymerization.	GW 4869	170-176	interleukin 1 beta	Homo sapiens	62-70
29712570-7	2018	We further examined the role of sphingolipid signaling in the IL-1beta-mediated impairment of spine plasticity and found that both the neutral sphingomyelinase inhibitor GW4869 and the inhibitor of Src kinase PP2 attenuated the IL-1beta-mediated suppression of cLTP-induced surface expression of GluA1 and actin polymerization.	GW 4869	170-176	interleukin 1 beta	Homo sapiens	228-236
29712570-7	2018	We further examined the role of sphingolipid signaling in the IL-1beta-mediated impairment of spine plasticity and found that both the neutral sphingomyelinase inhibitor GW4869 and the inhibitor of Src kinase PP2 attenuated the IL-1beta-mediated suppression of cLTP-induced surface expression of GluA1 and actin polymerization.	cltp	261-265	interleukin 1 beta	Homo sapiens	62-70
29577119-8	2018	The results showed that IPT significantly reduced cell viability, accelerated cell apoptosis and decreased matrix metalloproteinases-1/-3 expression in IL-1beta-induced RA-FLSs.	imperatorin	24-27	interleukin 1 beta	Homo sapiens	152-160
29922281-4	2018	Extracellular ATP originating from injured cells is a prototypical second signal for inflammasome-dependent maturation and release of IL-1beta.	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	134-142
29922281-6	2018	Here, we demonstrate that physiological concentrations of AAT efficiently inhibit ATP-induced release of IL-1beta from primary human blood mononuclear cells, monocytic U937 cells, and rat lung tissue, whereas ATP-independent IL-1beta release is not impaired.	Adenosine Triphosphate	82-85	interleukin 1 beta	Homo sapiens	105-113
29922281-10	2018	We suggest that AAT controls ATP-induced IL-1beta release from human mononuclear blood cells by a novel triple-membrane-passing signaling pathway.	Adenosine Triphosphate	29-32	interleukin 1 beta	Homo sapiens	41-49
29712570-0	2018	IL-1beta suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.	cltp	20-24	interleukin 1 beta	Homo sapiens	0-8
29531138-4	2018	In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	interleukin 1 beta	Homo sapiens	122-130
29676014-5	2018	In addition, the successful use of macrolide antibiotics to treat lung infections in these conditions further confirms that the innate immune system is the key conductor of inflammation in these pulmonary diseases, as there is a strong body of evidence that macrolides are able to modulate the NLRP3 inflammasome and interleukin-1beta and interleukin-18 secretion, both of which are central players in the innate immune response.	Macrolides	35-44	interleukin 1 beta	Homo sapiens	317-334
29531138-4	2018	In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	interleukin 1 beta	Homo sapiens	103-120
29676014-5	2018	In addition, the successful use of macrolide antibiotics to treat lung infections in these conditions further confirms that the innate immune system is the key conductor of inflammation in these pulmonary diseases, as there is a strong body of evidence that macrolides are able to modulate the NLRP3 inflammasome and interleukin-1beta and interleukin-18 secretion, both of which are central players in the innate immune response.	Macrolides	258-268	interleukin 1 beta	Homo sapiens	317-334
29849489-3	2018	Hence, we examined the association of IL-1 RN and IL-1beta polymorphisms with ARV-associated hepatotoxicity.	omega-N-Allylarginine	78-81	interleukin 1 beta	Homo sapiens	50-58
29592953-8	2018	RNA sequencing analysis showed that LY500307 could induce up-regulation of IL-1beta in TNBC and melanoma cells, which further triggered antitumor neutrophil chemotaxis.	erteberel	36-44	interleukin 1 beta	Homo sapiens	75-83
29774080-12	2018	TSA also increased AGGRECAN expression and decreased MMP13 expression in IL-1beta-treated PHCs.	trichostatin A	0-3	interleukin 1 beta	Homo sapiens	73-81
29674687-10	2018	Similarly, celecoxib prevented IL-1beta-mediated induction of IL-6.	Celecoxib	11-20	interleukin 1 beta	Homo sapiens	31-39
29651107-8	2018	Over-expression of circ-4099 increased the expression of Collagen II and Aggrecan and decreased the secretion of the pro-inflammatory factors IL-1beta, TNF-alpha, and PGE2.	circ	19-23	interleukin 1 beta	Homo sapiens	142-150
29643332-3	2018	We combine genetic, molecular, and pharmacological approaches to identify an essential function of hepatic macrophages and IL-1beta in PNAC.	pnac	135-139	interleukin 1 beta	Homo sapiens	123-131
29643332-6	2018	Thus, hepatic macrophages, IL-1beta, or NF-kappaB may be targets for restoring bile and sterol transport to treat PNAC.	Sterols	88-94	interleukin 1 beta	Homo sapiens	27-35
29642561-0	2018	beta-Nicotinamide Adenine Dinucleotide (beta-NAD) Inhibits ATP-Dependent IL-1beta Release from Human Monocytic Cells.	NAD	0-38	interleukin 1 beta	Homo sapiens	73-81
29642561-0	2018	beta-Nicotinamide Adenine Dinucleotide (beta-NAD) Inhibits ATP-Dependent IL-1beta Release from Human Monocytic Cells.	NAD	40-48	interleukin 1 beta	Homo sapiens	73-81
29642561-0	2018	beta-Nicotinamide Adenine Dinucleotide (beta-NAD) Inhibits ATP-Dependent IL-1beta Release from Human Monocytic Cells.	Adenosine Triphosphate	59-62	interleukin 1 beta	Homo sapiens	73-81
29642561-2	2018	ATP, a stimulus of IL-1beta maturation, is released from damaged cells along with beta-nicotinamide adenine dinucleotide (beta-NAD).	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	19-27
29642561-2	2018	ATP, a stimulus of IL-1beta maturation, is released from damaged cells along with beta-nicotinamide adenine dinucleotide (beta-NAD).	NAD	82-120	interleukin 1 beta	Homo sapiens	19-27
29642561-2	2018	ATP, a stimulus of IL-1beta maturation, is released from damaged cells along with beta-nicotinamide adenine dinucleotide (beta-NAD).	NAD	122-130	interleukin 1 beta	Homo sapiens	19-27
29642561-3	2018	Here, we tested the hypothesis that beta-NAD controls ATP-signaling and, hence, IL-1beta release.	NAD	36-44	interleukin 1 beta	Homo sapiens	80-88
29642561-7	2018	Exogenous beta-NAD signaled via P2Y receptors and dose-dependently (IC50 = 15 microM) suppressed the BzATP-induced IL-1beta release.	NAD	10-18	interleukin 1 beta	Homo sapiens	115-123
29642561-7	2018	Exogenous beta-NAD signaled via P2Y receptors and dose-dependently (IC50 = 15 microM) suppressed the BzATP-induced IL-1beta release.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	101-106	interleukin 1 beta	Homo sapiens	115-123
29849489-7	2018	IL-1beta-511TT genotype among alcohol users increased the risk for hepatotoxicity (OR = 1.80, P = 0.90).	Alcohols	30-37	interleukin 1 beta	Homo sapiens	0-8
29849489-8	2018	IL-1beta-511CT and -511TT genotypes overrepresented in alcohol using HIV-infected individuals (OR = 2.29, P = 0.27; OR = 2.64, P = 0.19).	Alcohols	55-62	interleukin 1 beta	Homo sapiens	0-8
29849489-10	2018	IL-1beta-511CT and -511 TT genotypes among nevirapine users enhanced the risk for severe hepatotoxicity (OR = 4.29, P = 0.20; OR = 1.95, P = 0.56).	Nevirapine	43-53	interleukin 1 beta	Homo sapiens	0-8
29849489-11	2018	IL-1beta-511CT and -511TT genotypes were overrepresented in combined nevirapine and alcohol using HIV-infected individuals as compared to nevirapine users and alcohol nonusers (OR = 2.56, P = 0.26; OR = 2.84, P = 0.24).	Nevirapine	69-79	interleukin 1 beta	Homo sapiens	0-8
29849489-11	2018	IL-1beta-511CT and -511TT genotypes were overrepresented in combined nevirapine and alcohol using HIV-infected individuals as compared to nevirapine users and alcohol nonusers (OR = 2.56, P = 0.26; OR = 2.84, P = 0.24).	Alcohols	84-91	interleukin 1 beta	Homo sapiens	0-8
29849489-11	2018	IL-1beta-511CT and -511TT genotypes were overrepresented in combined nevirapine and alcohol using HIV-infected individuals as compared to nevirapine users and alcohol nonusers (OR = 2.56, P = 0.26; OR = 2.84, P = 0.24).	Nevirapine	138-148	interleukin 1 beta	Homo sapiens	0-8
29849489-11	2018	IL-1beta-511CT and -511TT genotypes were overrepresented in combined nevirapine and alcohol using HIV-infected individuals as compared to nevirapine users and alcohol nonusers (OR = 2.56, P = 0.26; OR = 2.84, P = 0.24).	Alcohols	159-166	interleukin 1 beta	Homo sapiens	0-8
29849489-12	2018	IL-1beta-511TT genotype with tobacco, alcohol, and nevirapine usage revealed a trend of risk for the development of ARV-associated hepatotoxicity and its severity.	Alcohols	38-45	interleukin 1 beta	Homo sapiens	0-8
29849500-7	2018	The result showed that CBT effectively suppressed the expressions of TNF-alpha, IL-6, MCP-1, and IL-1beta in a dose-dependent manner and significantly downregulated 19 out of 32 differentially expressed genes, most of which were involved in the NOD1/NF-kappaB pathway, and also showed that CBT remarkably inhibited LPS-induced NOD1, RIP2, and NF-kappaB activation.	columbianetin	23-26	interleukin 1 beta	Homo sapiens	97-105
29642561-10	2018	In conclusion, we describe a novel triple membrane-passing signaling cascade triggered by extracellular beta-NAD that suppresses ATP-induced release of IL-1beta by monocytic cells.	NAD	104-112	interleukin 1 beta	Homo sapiens	152-160
29642561-10	2018	In conclusion, we describe a novel triple membrane-passing signaling cascade triggered by extracellular beta-NAD that suppresses ATP-induced release of IL-1beta by monocytic cells.	Adenosine Triphosphate	129-132	interleukin 1 beta	Homo sapiens	152-160
29850615-6	2018	Accordingly, the expression of A-FABP and the release of the proinflammatory cytokines TNF-alpha and IL-1beta also increased in response to constant high glucose, an effect that also was more evident in intermittent high glucose.	Glucose	154-161	interleukin 1 beta	Homo sapiens	101-109
29850615-6	2018	Accordingly, the expression of A-FABP and the release of the proinflammatory cytokines TNF-alpha and IL-1beta also increased in response to constant high glucose, an effect that also was more evident in intermittent high glucose.	Glucose	221-228	interleukin 1 beta	Homo sapiens	101-109
29850615-7	2018	The inhibition of p-JNK by SP600125 did not attenuate TLR4 expression, but totally inhibited both A-FABP expression and the production of the proinflammatory cytokines TNF-alpha and IL-1beta in both constant and intermittent high glucose.	pyrazolanthrone	27-35	interleukin 1 beta	Homo sapiens	182-190
29356862-2	2018	HBCD and TBBPA have been shown to alter the tumor killing function of natural killer (NK) lymphocytes and the secretion of the inflammatory cytokines interferon gamma (IFNgamma) and interleukin 1 beta (IL-1beta).	tetrabromobisphenol A	9-14	interleukin 1 beta	Homo sapiens	182-200
29356862-2	2018	HBCD and TBBPA have been shown to alter the tumor killing function of natural killer (NK) lymphocytes and the secretion of the inflammatory cytokines interferon gamma (IFNgamma) and interleukin 1 beta (IL-1beta).	tetrabromobisphenol A	9-14	interleukin 1 beta	Homo sapiens	202-210
29781747-5	2018	The effects of CS on immune activity was evaluated flow cytometrically in these cells by assessment of phagocytosis and intracellular expression IL-1beta and IL-10.	Cesium	15-17	interleukin 1 beta	Homo sapiens	145-153
28268030-8	2018	Gene-fatty acid interaction was found between the IL1B gene SNP rs116944 and stearic acid (p inter = 0.043), and between rs1143634 and EPA (p inter = 0.017).	Fatty Acids	5-15	interleukin 1 beta	Homo sapiens	50-54
28268030-8	2018	Gene-fatty acid interaction was found between the IL1B gene SNP rs116944 and stearic acid (p inter = 0.043), and between rs1143634 and EPA (p inter = 0.017).	stearic acid	77-89	interleukin 1 beta	Homo sapiens	50-54
28268030-11	2018	Plasma fatty acid profile interacts with the IL1B and IL10 gene variants to modulate the odds for MetS.	Fatty Acids	7-17	interleukin 1 beta	Homo sapiens	45-49
29397417-4	2018	The terminal ileum IFN-gamma, IL-6, and IL-1beta were elevated in CD-new, while in the colon, the IFN-gamma, IL-17A, and IL-6 were elevated in both CD-new and CD-treated subgroups.	cd-new	66-72	interleukin 1 beta	Homo sapiens	40-48
28780654-10	2018	In the Se-deficient group, the mRNA expression levels of IL-1R and IL-1beta were higher than those of three control organs.	Selenium	7-9	interleukin 1 beta	Homo sapiens	67-75
29363544-7	2018	Targeting IRAK4 or IL1beta rendered PDAC tumors less fibrotic and more sensitive to gemcitabine.	gemcitabine	84-95	interleukin 1 beta	Homo sapiens	19-26
28898431-6	2018	RESULTS: Schisandrin C inhibited lipopolysaccharide-stimulated inflammatory molecules; interleukin 1 beta, tumour necrosis factor alpha, intracellular adhesion molecule-1, vascular cell adhesion molecule-1, matrix metalloproteinase-2 and -9, NO production, ROS formation, nuclear factor kappa B translocation (P &lt; 0.05) through the mitogen-activated protein kinase pathway.	schizandrin C	9-22	interleukin 1 beta	Homo sapiens	87-170
29303154-12	2018	Interleukin 1 receptor antagonist/interleukin 1b (IL1RA/IL1b) ratio was 13 times higher in DME patients as compared with Hr-PDR group.ConclusionWe demonstrated a simple, safe method of VR sampling.	dme	91-94	interleukin 1 beta	Homo sapiens	56-60
29303154-14	2018	IL1RA/IL1b ratio was found to be 13-fold higher in the DME group as compared to the Hr-PDR.	dme	55-58	interleukin 1 beta	Homo sapiens	6-10
29393342-11	2018	pLVX-Puro-CTHRC1 mimics the effect of IL-1beta on chondrocyte apoptosis and JNK1/2 activity, and this is reversed by SP600125 treatment.	pyrazolanthrone	117-125	interleukin 1 beta	Homo sapiens	38-46
29256007-5	2018	RESULTS: IL-1beta decreased genomic methylation of human intestinal epithelial cells and induced demethylation at cg-specific sites at the promoter of pro-inflammatory genes IL6 and IL8; conversely it did not change the methylation of the IL10 promoter.	cysteinylglycine	114-116	interleukin 1 beta	Homo sapiens	9-17
29393342-12	2018	However, transfection with shRNA-CTHRC1 or treatment with SP600125 inhibited IL-1beta-induced cell apoptosis and JNK1/2 activation.	pyrazolanthrone	58-66	interleukin 1 beta	Homo sapiens	77-85
29542225-5	2018	First, we found that memantine treatment prevented I/R-induced expression of tumor necrosis factor-alpha and interleukin-1beta at both the mRNA and the protein levels.	Memantine	21-30	interleukin 1 beta	Homo sapiens	109-126
29067681-11	2018	Fifty-one genes were identified as molecular targets upregulated by IL-1 beta and downregulated by the chitosan-triclosan particles.	Chitosan	103-111	interleukin 1 beta	Homo sapiens	68-77
29454604-8	2018	Bisphosphonates could result in increase of IL-1beta expression of fibroblasts.	Diphosphonates	0-15	interleukin 1 beta	Homo sapiens	44-52
28110479-0	2018	Epigallocatechin-3-O-gallate modulates global microRNA expression in interleukin-1beta-stimulated human osteoarthritis chondrocytes: potential role of EGCG on negative co-regulation of microRNA-140-3p and ADAMTS5.	epigallocatechin gallate	0-28	interleukin 1 beta	Homo sapiens	69-86
28110479-0	2018	Epigallocatechin-3-O-gallate modulates global microRNA expression in interleukin-1beta-stimulated human osteoarthritis chondrocytes: potential role of EGCG on negative co-regulation of microRNA-140-3p and ADAMTS5.	epigallocatechin gallate	151-155	interleukin 1 beta	Homo sapiens	69-86
28110479-3	2018	This study was undertaken to investigate the global effect of EGCG on interleukin-1beta (IL-1beta)-induced expression of miRNAs in human chondrocytes.	epigallocatechin gallate	62-66	interleukin 1 beta	Homo sapiens	70-87
28110479-3	2018	This study was undertaken to investigate the global effect of EGCG on interleukin-1beta (IL-1beta)-induced expression of miRNAs in human chondrocytes.	epigallocatechin gallate	62-66	interleukin 1 beta	Homo sapiens	89-97
28110479-10	2018	Importantly, EGCG inhibited IL-1beta-induced ADAMTS5 expression and up-regulated the expression of hsa-miR-140-3p.	epigallocatechin gallate	13-17	interleukin 1 beta	Homo sapiens	28-36
29350834-4	2018	Pantoprazole stimulation additionally reduced the production of the proinflammatory cytokine IL-1beta in whole blood assay as well as the production of IL-2 and IFN-gamma after whole blood stimulation with phytohaemagglutinin.	Pantoprazole	0-12	interleukin 1 beta	Homo sapiens	93-101
29067681-11	2018	Fifty-one genes were identified as molecular targets upregulated by IL-1 beta and downregulated by the chitosan-triclosan particles.	Triclosan	112-121	interleukin 1 beta	Homo sapiens	68-77
29067681-13	2018	Furthermore, using real-time reverse transcription-polymerase chain reaction beta-actin, fibronectin, interleukin-6 and IL-1b genes were confirmed as targets upregulated by IL-1beta and downregulated by chitosan-triclosan particles.	Chitosan	203-211	interleukin 1 beta	Homo sapiens	120-125
29067681-13	2018	Furthermore, using real-time reverse transcription-polymerase chain reaction beta-actin, fibronectin, interleukin-6 and IL-1b genes were confirmed as targets upregulated by IL-1beta and downregulated by chitosan-triclosan particles.	Triclosan	212-221	interleukin 1 beta	Homo sapiens	120-125
28862770-7	2018	CONCLUSIONS: Both strategies alleviated symptoms in short term, but the patients treated with GS benefited more than those with placebo in long term, which may be due to the suppression of IL-1beta and IL-6 and the stimulation of TGF-beta.	Glucosamine	94-96	interleukin 1 beta	Homo sapiens	189-197
29432801-8	2018	The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release.	Glyburide	33-46	interleukin 1 beta	Homo sapiens	267-275
29411263-6	2018	We found that a pretreatment with NGN at 80 microM for 2 h decreased the levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in PQ-treated SH-SY5Y cells.	naringenin	34-37	interleukin 1 beta	Homo sapiens	110-127
29411263-6	2018	We found that a pretreatment with NGN at 80 microM for 2 h decreased the levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in PQ-treated SH-SY5Y cells.	naringenin	34-37	interleukin 1 beta	Homo sapiens	129-137
29411263-6	2018	We found that a pretreatment with NGN at 80 microM for 2 h decreased the levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in PQ-treated SH-SY5Y cells.	Paraquat	186-188	interleukin 1 beta	Homo sapiens	110-127
29411263-6	2018	We found that a pretreatment with NGN at 80 microM for 2 h decreased the levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in PQ-treated SH-SY5Y cells.	Paraquat	186-188	interleukin 1 beta	Homo sapiens	129-137
29432801-8	2018	The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release.	n-benzyloxycarbony	117-135	interleukin 1 beta	Homo sapiens	267-275
29432801-8	2018	The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release.	Alanine	140-143	interleukin 1 beta	Homo sapiens	267-275
29432801-8	2018	The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release.	fluoromethylketone	159-177	interleukin 1 beta	Homo sapiens	267-275
29432801-9	2018	Moreover, the levels of IL-1beta and IL-18 production decreased in CA-074 (a cathepsin B inhibitor) and NAC (an anti-oxidant) pretreated human macrophages, compared to untreated controls.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	67-73	interleukin 1 beta	Homo sapiens	24-32
29432801-10	2018	This study suggests that L. interrogans infection leads to reactive oxygen species (ROS)- and cathepsin B-dependent NLRP3 inflammasome activation, which subsequently mediates caspase-1 activation and IL-1beta and IL-18 release.	Reactive Oxygen Species	59-82	interleukin 1 beta	Homo sapiens	200-208
29432801-10	2018	This study suggests that L. interrogans infection leads to reactive oxygen species (ROS)- and cathepsin B-dependent NLRP3 inflammasome activation, which subsequently mediates caspase-1 activation and IL-1beta and IL-18 release.	Reactive Oxygen Species	84-87	interleukin 1 beta	Homo sapiens	200-208
29522792-6	2018	Of the statins investigated, only atorvastatin, pravastatin and rosuvastatin protected SH-SY5Y cells from LPS-induced decreases in cellular viability; this appeared mediated through reduced caspase 3/7 activation and was associated with decreased IL-1beta (atorvastatin, pravastatin) and/or TNF-alpha (atorvastatin, pravastatin, rosuvastatin).	Atorvastatin	34-46	interleukin 1 beta	Homo sapiens	247-255
29589999-11	2018	The IL-1beta-induced hyaluronan production and mRNA expression of IL-6, cyclooxygenase-2, and intercellular adhesion molecule-1 were also significantly suppressed after metformin or phenformin co-treatment.	Hyaluronic Acid	21-31	interleukin 1 beta	Homo sapiens	4-12
28820025-4	2018	We examined interleukin (IL)-1beta regulation of the expression of PR-A, PR-B, and genes governing prostaglandin synthesis in human cervical fibroblasts (HCFs).	Prostaglandins	99-112	interleukin 1 beta	Homo sapiens	12-34
28820025-11	2018	Blockade of prostaglandin synthesis (indomethacin) prevented both the IL-1beta-induced increase in PR mRNA and the acute decrease in PR-A and PR-B protein, implicating a role for prostaglandins in regulating PR expression in HCFs.	Prostaglandins	12-25	interleukin 1 beta	Homo sapiens	70-78
28820025-11	2018	Blockade of prostaglandin synthesis (indomethacin) prevented both the IL-1beta-induced increase in PR mRNA and the acute decrease in PR-A and PR-B protein, implicating a role for prostaglandins in regulating PR expression in HCFs.	Indomethacin	37-49	interleukin 1 beta	Homo sapiens	70-78
28820025-11	2018	Blockade of prostaglandin synthesis (indomethacin) prevented both the IL-1beta-induced increase in PR mRNA and the acute decrease in PR-A and PR-B protein, implicating a role for prostaglandins in regulating PR expression in HCFs.	Prostaglandins	179-193	interleukin 1 beta	Homo sapiens	70-78
29446486-0	2018	Interleukin-17A participates in podocyte injury by inducing IL-1beta secretion through ROS-NLRP3 inflammasome-caspase-1 pathway.	ros	87-90	interleukin 1 beta	Homo sapiens	60-68
29686772-4	2018	7-MEGA effectively attenuated generation of H2O2-induced reactive oxygen species (ROS), and inhibited H2O2-induced inflammatory factors, such as prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta).	7-mega	0-6	interleukin 1 beta	Homo sapiens	215-232
29589999-11	2018	The IL-1beta-induced hyaluronan production and mRNA expression of IL-6, cyclooxygenase-2, and intercellular adhesion molecule-1 were also significantly suppressed after metformin or phenformin co-treatment.	Metformin	169-178	interleukin 1 beta	Homo sapiens	4-12
29589999-11	2018	The IL-1beta-induced hyaluronan production and mRNA expression of IL-6, cyclooxygenase-2, and intercellular adhesion molecule-1 were also significantly suppressed after metformin or phenformin co-treatment.	Phenformin	182-192	interleukin 1 beta	Homo sapiens	4-12
29686772-4	2018	7-MEGA effectively attenuated generation of H2O2-induced reactive oxygen species (ROS), and inhibited H2O2-induced inflammatory factors, such as prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta).	7-mega	0-6	interleukin 1 beta	Homo sapiens	234-242
29522792-6	2018	Of the statins investigated, only atorvastatin, pravastatin and rosuvastatin protected SH-SY5Y cells from LPS-induced decreases in cellular viability; this appeared mediated through reduced caspase 3/7 activation and was associated with decreased IL-1beta (atorvastatin, pravastatin) and/or TNF-alpha (atorvastatin, pravastatin, rosuvastatin).	Rosuvastatin Calcium	64-76	interleukin 1 beta	Homo sapiens	247-255
29588466-0	2018	Canagliflozin inhibits interleukin-1beta-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms.	Canagliflozin	0-13	interleukin 1 beta	Homo sapiens	23-40
29386291-11	2018	Moreover, we identified two target lysine residues, K110 and K140, which are essential for both porcine ASC ubiquitination and NLRP3 inflammasome-mediated IL-1beta production.	Lysine	35-41	interleukin 1 beta	Homo sapiens	155-163
29588466-5	2018	Incubation with clinically-relevant concentrations of canagliflozin, but not empagliflozin or dapagliflozin activated AMPK and inhibited IL-1beta-stimulated adhesion of pro-monocytic U937 cells and secretion of IL-6 and monocyte chemoattractant protein-1 (MCP-1).	Canagliflozin	54-67	interleukin 1 beta	Homo sapiens	137-145
29588466-8	2018	Despite these identical effects of canagliflozin and A769662, IL-1beta-stimulated IL-6/MCP-1 mRNA was inhibited by canagliflozin, but not A769662, whereas IL-1beta-stimulated c-jun N-terminal kinase phosphorylation was inhibited by A769662, but not canagliflozin.	Canagliflozin	35-48	interleukin 1 beta	Homo sapiens	62-70
29594175-7	2018	NTHi induced IL-1beta secretion in PBMCs from both healthy controls and patients with recurrent PBB.	nthi	0-4	interleukin 1 beta	Homo sapiens	13-21
29588470-8	2018	Furthermore, TPPU significantly lowered the mRNA expression of interleukin-1beta by 3.5-fold and tumor necrosis factor-alpha by 2.2-fold, increased transforming growth factor-beta mRNA by 1.8-fold, and augmented immunostaining of vascular endothelial growth factor in peri-infarct cortex.	TPPU	13-17	interleukin 1 beta	Homo sapiens	63-80
29594175-9	2018	In PBB BAL macrophages inflammasome complexes were visualised as fluorescence specks of NLRP3 or AIM2 colocalised with cleaved caspase-1 and cleaved IL-1beta.	pbb	3-6	interleukin 1 beta	Homo sapiens	149-157
29594175-10	2018	NTHi stimulation induced formation of specks of cleaved IL-1beta, NLRP3 and AIM2 in PBMCs, blood monocytes and monocyte-derived macrophages.	nthi	0-4	interleukin 1 beta	Homo sapiens	56-64
29623041-7	2018	Withaferin A ameliorated the expression of inflammatory cytokines including NF-kappaB p65, IL-1beta and TNF-alpha, as well as attenuated the expression of pro-fibrotic proteins including CTGF, collagen 1A2, collagen 3A1, and fibronectin.	withaferin A	0-12	interleukin 1 beta	Homo sapiens	91-99
29414774-4	2018	We found that glucose starvation sensitizes glioma cells to IL-1beta-induced apoptosis in a manner that depended on reactive oxygen species (ROS).	Reactive Oxygen Species	116-139	interleukin 1 beta	Homo sapiens	60-68
29414774-4	2018	We found that glucose starvation sensitizes glioma cells to IL-1beta-induced apoptosis in a manner that depended on reactive oxygen species (ROS).	Reactive Oxygen Species	141-144	interleukin 1 beta	Homo sapiens	60-68
29554943-0	2018	Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1beta on rheumatoid arthritis fibroblast-like synoviocytes.	Methotrexate	0-12	interleukin 1 beta	Homo sapiens	68-85
29743866-5	2018	Data from ELISA and Western blot assays showed that Dex abrogated the promoting effects of LPS/ATP on the release of pro-inflammatory cytokines including IL-1beta and IL-18 in the cell medium and the expression of NLRP3 and its downstream target caspase-1 in HMC3 cells.	Dexmedetomidine	52-55	interleukin 1 beta	Homo sapiens	154-162
29743866-5	2018	Data from ELISA and Western blot assays showed that Dex abrogated the promoting effects of LPS/ATP on the release of pro-inflammatory cytokines including IL-1beta and IL-18 in the cell medium and the expression of NLRP3 and its downstream target caspase-1 in HMC3 cells.	Adenosine Triphosphate	95-98	interleukin 1 beta	Homo sapiens	154-162
29554943-12	2018	CONCLUSIONS: Therapeutic concentrations of MTX abolish the effects of PDGF and IL-1beta on tumor suppressor expression and inhibit mitogen-promoted FLS proliferation.	Methotrexate	43-46	interleukin 1 beta	Homo sapiens	79-87
29662436-6	2018	Most findings indicate that eCBs seem to counteract the activation of major neuroinflammatory pathways that lead to glia-mediated production of TNF-alpha and IL-1beta, both well-known triggers of astroglial hemichannel opening.	ecbs	28-32	interleukin 1 beta	Homo sapiens	158-166
29543732-0	2018	Indoxyl Sulfate Promotes Macrophage IL-1beta Production by Activating Aryl Hydrocarbon Receptor/NF-kappa/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated.	Indican	0-15	interleukin 1 beta	Homo sapiens	36-44
29529198-9	2018	AS002 and rosiglitazone increased ADIPOPHILIN mRNA expression (3-fold) and decreased TNF-alpha, IL-1beta, and IL-13 levels in human UC biopsies.	Rosiglitazone	10-23	interleukin 1 beta	Homo sapiens	96-104
29743981-3	2018	Heme, released from RBCs, is a DAMP and induces IL-1beta production through the activation of the nucleotide-binding domain and leucine-rich repeat-containing family and pyrin domain containing 3 (NLRP3) in macrophages; however, other cellular targets of heme-mediated inflammasome activation were not investigated.	Heme	0-4	interleukin 1 beta	Homo sapiens	48-56
29743981-3	2018	Heme, released from RBCs, is a DAMP and induces IL-1beta production through the activation of the nucleotide-binding domain and leucine-rich repeat-containing family and pyrin domain containing 3 (NLRP3) in macrophages; however, other cellular targets of heme-mediated inflammasome activation were not investigated.	Heme	255-259	interleukin 1 beta	Homo sapiens	48-56
29743981-5	2018	We found that heme upregulated NLRP3 expression and induced active IL-1beta production in human umbilical vein endothelial cells (HUVECs).	Heme	14-18	interleukin 1 beta	Homo sapiens	67-75
29743981-6	2018	LPS priming largely amplified the heme-mediated production of IL-1beta.	Heme	34-38	interleukin 1 beta	Homo sapiens	62-70
29530050-6	2018	Ionomycin A and thapsigargin also increased intracellular Ca2+ levels and production of IL-1beta and TNF-alpha, mimicking the effect of Abeta1-42.	ionomycin a	0-11	interleukin 1 beta	Homo sapiens	88-96
29530050-12	2018	Moreover, sulforaphane"s anti-inflammatory effects on Abeta1-42-induced production of IL-1beta and TNF-alpha were significantly diminished by siRNA-mediated knockdown of MerTK, confirming a critical role of MerTK in suppressing Abeta1-42-induced innate immune response.	sulforaphane	10-22	interleukin 1 beta	Homo sapiens	86-94
29530050-6	2018	Ionomycin A and thapsigargin also increased intracellular Ca2+ levels and production of IL-1beta and TNF-alpha, mimicking the effect of Abeta1-42.	Thapsigargin	16-28	interleukin 1 beta	Homo sapiens	88-96
29530050-10	2018	Notably, sulforaphane treatment potently inhibited Abeta1-42-induced intracellular Ca2+ level and rescued the decrease in MerTK expression by blocking nuclear factor-kappaB (NF-kappaB) nuclear translocation, thereby decreasing IL-1beta and TNF-alpha production upon Abeta1-42 stimulation.	sulforaphane	9-21	interleukin 1 beta	Homo sapiens	227-235
29928672-9	2018	Epinephrine and Foradil also exacerbated LPS-induced IL1beta activation in human THP-1-derived macrophages, by increasing acetylated H4K12, and these increases were abrogated by propranolol.	Formoterol Fumarate	16-23	interleukin 1 beta	Homo sapiens	53-60
29432948-1	2018	4-phenylpyridin-2-yl-guanidine (5b): a new inhibitor of the overproduction of pro-inflammatory cytokines (TNFalpha and Il1beta) was identified from a high-throughput screening of a chemical library on human peripheral blood mononuclear cells (PBMCs) after LPS stimulation.	4-phenylpyridin-2-yl-guanidine	0-30	interleukin 1 beta	Homo sapiens	119-126
29928672-9	2018	Epinephrine and Foradil also exacerbated LPS-induced IL1beta activation in human THP-1-derived macrophages, by increasing acetylated H4K12, and these increases were abrogated by propranolol.	Propranolol	178-189	interleukin 1 beta	Homo sapiens	53-60
29374549-10	2018	Moreover, the AGE-mediated increase in IL-1beta expression in cell culture supernatants was also reduced by co-treatment with matrine in a concentration-dependent manner.	matrine	126-133	interleukin 1 beta	Homo sapiens	39-47
29507357-6	2018	We confirmed that miR-125a-5p and miR-16-5p (both enriched in ADEV-IL-1beta and ADEV-TNFalpha) targeted NTKR3 and its downstream effector Bcl2.	mir-125a-5p	18-29	interleukin 1 beta	Homo sapiens	67-75
29514093-6	2018	Interleukin (IL)-23 and IL-1beta promoted glucose uptake and increased glycolysis.	Glucose	42-49	interleukin 1 beta	Homo sapiens	24-32
29266807-4	2018	The results show that the functionalized surfaces downregulate the release of hydrogen peroxide and proinflammatory cytokines (tumor necrosis factor alpha and interleukin 1 beta) from human monocytes and neutrophils, compared to nonfunctionalized discs.	Hydrogen Peroxide	78-95	interleukin 1 beta	Homo sapiens	159-177
29507357-6	2018	We confirmed that miR-125a-5p and miR-16-5p (both enriched in ADEV-IL-1beta and ADEV-TNFalpha) targeted NTKR3 and its downstream effector Bcl2.	mir-16-5p	34-43	interleukin 1 beta	Homo sapiens	67-75
29507357-8	2018	Molecular interference of miR-125a-5p and miR-16-5p prevented ADEV-IL-1beta from reducing dendritic complexity, spike, and burst rates.	mir-125a	26-34	interleukin 1 beta	Homo sapiens	67-75
29507357-8	2018	Molecular interference of miR-125a-5p and miR-16-5p prevented ADEV-IL-1beta from reducing dendritic complexity, spike, and burst rates.	mir-16-5p	42-51	interleukin 1 beta	Homo sapiens	67-75
29274621-9	2018	LPS (1 mug/ml), TNF-alpha (10 ng/ml), and IL-1beta (1 ng/ml) increased IL-6 and MCP-1 production, which were inhibited by AEA, SMM-189, and HU-308.	anandamide	122-125	interleukin 1 beta	Homo sapiens	42-50
29248584-8	2018	Cells treated with dexamethasone alone at both the concentrations inhibit the mRNAs expression of IL-1beta, IL-6 and TNF-alpha compared to control.	Dexamethasone	19-32	interleukin 1 beta	Homo sapiens	98-106
29274621-5	2018	The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-alpha, or IL-1beta.	Cannabinoids	38-50	interleukin 1 beta	Homo sapiens	274-282
29193391-6	2018	However, DHM pretreatment inhibited PA-induced pyroptotic cell death by increasing cell viability, decreasing LDH and IL-1beta release, improving cell membrane integrity, and abolishing caspase-1 cleavage and subsequent IL-1beta maturation.	dihydromyricetin	9-12	interleukin 1 beta	Homo sapiens	118-126
29193391-6	2018	However, DHM pretreatment inhibited PA-induced pyroptotic cell death by increasing cell viability, decreasing LDH and IL-1beta release, improving cell membrane integrity, and abolishing caspase-1 cleavage and subsequent IL-1beta maturation.	dihydromyricetin	9-12	interleukin 1 beta	Homo sapiens	220-228
29193391-6	2018	However, DHM pretreatment inhibited PA-induced pyroptotic cell death by increasing cell viability, decreasing LDH and IL-1beta release, improving cell membrane integrity, and abolishing caspase-1 cleavage and subsequent IL-1beta maturation.	Palmitic Acid	36-38	interleukin 1 beta	Homo sapiens	118-126
29193391-6	2018	However, DHM pretreatment inhibited PA-induced pyroptotic cell death by increasing cell viability, decreasing LDH and IL-1beta release, improving cell membrane integrity, and abolishing caspase-1 cleavage and subsequent IL-1beta maturation.	Palmitic Acid	36-38	interleukin 1 beta	Homo sapiens	220-228
29331857-12	2018	In conclusion, this study demonstrated that baicalin protected CHON-001 cells against IL-1beta-induced inflammatory injury possibly via down-regulation of miR-126 and thereby deactivation of NF-kappaB signaling pathway.	chon	63-67	interleukin 1 beta	Homo sapiens	86-94
29193391-4	2018	In the present study, palmitic acid (PA) treatment led to pyroptosis in human umbilical vein endothelial cells (HUVECs), as evidenced by caspase-1 activation, LDH release, and propidium iodide-positive staining; enhanced the maturation and release of proinflammatory cytokine IL-1beta and activation of the NLRP3 inflammasome; and markedly increased intracellular reactive oxygen species (ROS) and mitochondrial ROS (mtROS) levels.	Palmitic Acid	22-35	interleukin 1 beta	Homo sapiens	276-284
29193391-4	2018	In the present study, palmitic acid (PA) treatment led to pyroptosis in human umbilical vein endothelial cells (HUVECs), as evidenced by caspase-1 activation, LDH release, and propidium iodide-positive staining; enhanced the maturation and release of proinflammatory cytokine IL-1beta and activation of the NLRP3 inflammasome; and markedly increased intracellular reactive oxygen species (ROS) and mitochondrial ROS (mtROS) levels.	Palmitic Acid	37-39	interleukin 1 beta	Homo sapiens	276-284
29331857-7	2018	Baicalin alleviated IL-1beta-induced inflammatory injury, as it increased cell viability, decreased cell apoptosis and repressed the production of IL-6, IL-8 and TNF-alpha.	baicalin	0-8	interleukin 1 beta	Homo sapiens	20-28
29331857-9	2018	More interestingly, the protective actions of baicalin on IL-1beta-injured CHON-001 cells were partially eliminated by miR-126 overexpression.	chon	75-79	interleukin 1 beta	Homo sapiens	58-66
29331857-12	2018	In conclusion, this study demonstrated that baicalin protected CHON-001 cells against IL-1beta-induced inflammatory injury possibly via down-regulation of miR-126 and thereby deactivation of NF-kappaB signaling pathway.	baicalin	44-52	interleukin 1 beta	Homo sapiens	86-94
29444596-4	2018	Our findings demonstrate that agonist arachidonyl-2-chloroethylamidedecreased senescence-associated beta-galactosidase activity and cell cycle arrest in the G0/G1 phase induced by interleukin-1beta.	arachidonyl-2-chloroethylamidedecreased	38-77	interleukin 1 beta	Homo sapiens	180-197
29444596-8	2018	These findings suggest that activation of cannabinoid receptor 1 by agonist arachidonyl-2-chloroethylamide might have a protective effect against pro-inflammatory cytokines such as interleukin-1beta-induced chondrocytes senescence in osteoarthritis patients.	arachidonyl-2-chloroethylamide	76-106	interleukin 1 beta	Homo sapiens	181-198
29318480-4	2018	The results indicated that rosmarinic acid reduced the expression of CD11b, a marker of microglia and macrophages, in the brain and dramatically inhibited the levels of inflammatory cytokines and mediators, such as TNFalpha, IL-6, IL-1beta, COX-2, and iNOS, in a dose-dependent manner both in vitro and in vivo.	rosmarinic acid	27-42	interleukin 1 beta	Homo sapiens	231-239
29264745-7	2018	We also report that IL-1beta interferes with thermogenesis via oxidative stress stimulation and mitochondrial dysfunction as we observed a statistically significant increase in ROS production, decrease in SOD enzyme activity, and increase in mitochondrial depolarization in adipocytes treated with IL-1beta.	ros	177-180	interleukin 1 beta	Homo sapiens	20-28
29268303-8	2018	Perillaldehyde and perillic acid suppressed the induction of nerve growth factor and tumor necrosis factor-alpha by interleukin-1beta in HT-1376 and normal human bladder epithelial cells.	perillaldehyde	0-14	interleukin 1 beta	Homo sapiens	116-133
29268303-8	2018	Perillaldehyde and perillic acid suppressed the induction of nerve growth factor and tumor necrosis factor-alpha by interleukin-1beta in HT-1376 and normal human bladder epithelial cells.	perillic acid	19-32	interleukin 1 beta	Homo sapiens	116-133
29275476-8	2018	Furthermore, lignosulfonic acid decreased the TNF-alpha- and IFN-gamma-induced increase in interleukin (IL)-1beta and IL-6 expression in Caco-2 cells.	LIGNOSULFONIC ACID	13-31	interleukin 1 beta	Homo sapiens	91-113
29356224-0	2018	Sauchinone prevents IL-1beta-induced inflammatory response in human chondrocytes.	sauchinone	0-10	interleukin 1 beta	Homo sapiens	20-28
29356224-2	2018	However, the functional roles of sauchinone in interleukin-1 beta (IL-1beta)-stimulated human osteoarthritis (OA) chondrocytes are still unknown.	sauchinone	33-43	interleukin 1 beta	Homo sapiens	47-65
29356224-2	2018	However, the functional roles of sauchinone in interleukin-1 beta (IL-1beta)-stimulated human osteoarthritis (OA) chondrocytes are still unknown.	sauchinone	33-43	interleukin 1 beta	Homo sapiens	67-75
29356224-3	2018	Thus, in this study, we investigated the anti-inflammatory effects of sauchinone in IL-1beta-stimulated chondrocytes.	sauchinone	70-80	interleukin 1 beta	Homo sapiens	84-92
29356224-4	2018	Our results demonstrated that sauchinone significantly attenuated NO and PGE2 production, as well as inhibited iNOS and COX-2 expression in IL-1beta-stimulated OA chondrocytes.	sauchinone	30-40	interleukin 1 beta	Homo sapiens	140-148
29356224-5	2018	In addition, sauchinone efficiently inhibited IL-1beta-induced MMP-3 and MMP-13 release in human OA chondrocytes.	sauchinone	13-23	interleukin 1 beta	Homo sapiens	46-54
29356224-7	2018	In conclusion, we showed for the first time that sauchinone inhibited inflammatory response in IL-1beta-stimulated human chondrocytes probably through inhibiting the activation of NF-kappaB signaling pathway.	sauchinone	49-59	interleukin 1 beta	Homo sapiens	95-103
29239061-0	2018	Progesterone inhibited endoplasmic reticulum stress associated apoptosis induced by interleukin-1beta via the GRP78/PERK/CHOP pathway in BeWo cells.	Progesterone	0-12	interleukin 1 beta	Homo sapiens	84-101
29239061-8	2018	The mechanism of progesterone acting on IL-1beta induced ERS associated apoptosis was investigated by reverse transcriptase-polymerase chain reaction, Western blot and PERK small interfering RNA, with RU486 used as a receptor inhibitor.	Mifepristone	201-206	interleukin 1 beta	Homo sapiens	40-48
29239061-10	2018	IL-1beta could induce ERS and associated cell apoptosis by activating the GRP78/PERK/CHOP signal pathway, which could be inhibited by progesterone.	Progesterone	134-146	interleukin 1 beta	Homo sapiens	0-8
29484338-0	2018	Polydatin inhibits the IL-1beta-induced inflammatory response in human osteoarthritic chondrocytes by activating the Nrf2 signaling pathway and ameliorates murine osteoarthritis.	polydatin	0-9	interleukin 1 beta	Homo sapiens	23-31
29024030-8	2018	Meanwhile, melatonin also attenuated the expression of pyroptosis-related genes, including NLRP3, ASC, cleaved caspase1, NF-kappaB/GSDMD, GSDMD N-termini, IL-1beta, and IL-18 in aortic endothelium of melatonin-treated animals.	Melatonin	11-20	interleukin 1 beta	Homo sapiens	155-163
28343296-9	2018	While cypermethrin increased the expression of interleukin-1beta, interleukin-4, interferon-gamma, inducible nitric oxide synthase, caspase-3, caspase-9 and B-cell lymphoma (Bcl)-xl proteins, it attenuated Bcl-2 expression.	cypermethrin	6-18	interleukin 1 beta	Homo sapiens	47-64
28765037-8	2018	We found a downregulation of CCL-2 after vitamin D treatment in IL1beta-stimulated monocytes both from AD patients and HC (AD p&lt;0.001; HC p&lt;0.0001).	Vitamin D	41-50	interleukin 1 beta	Homo sapiens	64-71
29335340-10	2018	Cit-ME, a genuine ligand of ACPA, inhibited the ACPA-induced upregulation of IL-1beta and IL-6 by 30%.	cit-me	0-6	interleukin 1 beta	Homo sapiens	77-85
29413111-8	2018	Furthermore, cytokine concentrations were independently associated with several mineral concentrations: IL-1beta with higher phosphorus and iron, IL-6 with higher calcium, magnesium, copper and manganese, IL-8 with higher calcium and zinc, and TNF-alpha with lower iron and manganese.	Phosphorus	125-135	interleukin 1 beta	Homo sapiens	104-112
29328385-0	2018	Tormentic acid inhibits IL-1beta-induced chondrocyte apoptosis by activating the PI3K/Akt signaling pathway.	euscaphic acid	0-14	interleukin 1 beta	Homo sapiens	24-32
28589946-0	2018	Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1beta-related lung injury.	Dinoprostone	9-25	interleukin 1 beta	Homo sapiens	63-80
29257341-0	2018	Carvacrol ameliorates inflammatory response in interleukin 1beta-stimulated human chondrocytes.	carvacrol	0-9	interleukin 1 beta	Homo sapiens	47-64
29257341-2	2018	The present study aimed to investigate the protective effects of carvacrol against inflammation in interleukin 1beta (IL-1beta)-stimulated human chondrocytes.	carvacrol	65-74	interleukin 1 beta	Homo sapiens	99-116
29257341-2	2018	The present study aimed to investigate the protective effects of carvacrol against inflammation in interleukin 1beta (IL-1beta)-stimulated human chondrocytes.	carvacrol	65-74	interleukin 1 beta	Homo sapiens	118-126
29257341-4	2018	Carvacrol also suppressed the protein expression levels of matrix metalloproteinase (MMP)-3 and MMP-13 in IL-1beta-stimulated human OA chondrocytes.	carvacrol	0-9	interleukin 1 beta	Homo sapiens	106-114
29257341-5	2018	Furthermore, carvacrol suppressed the activation of nuclear factor (NF)-kappaB signaling pathway in IL-1beta-induced human chondrocytes.	carvacrol	13-22	interleukin 1 beta	Homo sapiens	100-108
29257341-6	2018	In conclusion, the present results demonstrated that carvacrol was able to inhibit IL-1beta-induced NO and PGE2 production, as well as iNOS, COX-2 and MMPs expression in human chondrocytes by suppressing the activation of NF-kappaB signaling pathway.	carvacrol	53-62	interleukin 1 beta	Homo sapiens	83-91
29257341-6	2018	In conclusion, the present results demonstrated that carvacrol was able to inhibit IL-1beta-induced NO and PGE2 production, as well as iNOS, COX-2 and MMPs expression in human chondrocytes by suppressing the activation of NF-kappaB signaling pathway.	Dinoprostone	107-111	interleukin 1 beta	Homo sapiens	83-91
29328385-8	2018	The results revealed that pretreatment with TA inhibited IL-1beta-induced cytotoxicity and apoptosis in chondrocytes.	euscaphic acid	44-46	interleukin 1 beta	Homo sapiens	57-65
29328385-11	2018	Collectively, these results indicate that TA inhibits IL-1beta-induced chondrocyte apoptosis by activating the PI3K/Akt signaling pathway.	euscaphic acid	42-44	interleukin 1 beta	Homo sapiens	54-62
29474443-10	2018	Furthermore, inhibition of IL-1beta signaling by treatment with anakinra or exenatide increased beta-cell phospho-PKB levels, enhanced proliferation and reduced apoptosis in amyloid forming human islets during 7-day culture.	Exenatide	76-85	interleukin 1 beta	Homo sapiens	27-35
29140228-3	2018	rLd-iPGAM stimulation induced higher expression of interleukin-1beta (IL-1beta) in the phagocytic cell, its receptor and CD69 on T-cell subsets.	ipgam	4-9	interleukin 1 beta	Homo sapiens	51-68
29140228-3	2018	rLd-iPGAM stimulation induced higher expression of interleukin-1beta (IL-1beta) in the phagocytic cell, its receptor and CD69 on T-cell subsets.	ipgam	4-9	interleukin 1 beta	Homo sapiens	70-78
29197622-4	2018	Mechanistic study showed that dioscin significantly up-regulated the expression levels of Sirt3, SOD2, and then suppressed inflammation by decreasing the expression levels of NF-kB, HMGB1, c-Jun, c-Fos, COX2, TNF-alpha, IL-1beta and IL-6.	dioscin	30-37	interleukin 1 beta	Homo sapiens	220-228
29061028-3	2018	Treatment of panduratin A to LPS-stimulated HGF-1 significantly reduced the expression of interleukin-1beta and nuclear factor-kappa B (NF-kappaB), subsequently leading to the inhibition of matrix metalloproteinase-2 (MMP-2) and MMP-8 compared with that in the LPS control (**p &lt; 0.01).	panduratin A	13-25	interleukin 1 beta	Homo sapiens	90-107
29155016-3	2018	In this report, we demonstrated that in vitro, DZ2002 significantly decreased the expression of pro-inflammatory cytokines and adhesion molecule including IL-1alpha, IL-1beta, IL-6, IL-8, TNF-alpha and ICAM-1 by inhibiting the phosphorylation of p38 MAPK, ERK and JNK in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes.	methyl 4-(adenin-9-yl)-2-hydroxybutanoate	47-53	interleukin 1 beta	Homo sapiens	166-174
29495330-1	2018	(1) Background: Carotenoids may be inversely associated with inflammatory markers (i.e., TNF-alpha, IL-6, IL-1beta).	Carotenoids	16-27	interleukin 1 beta	Homo sapiens	106-114
29339024-5	2018	Human chondrocytes treated with IL-1beta resulted in robust Nrf2/ARE reporter activity, which was inhibited by pretreatment with antioxidants indicating that Nrf2 activity was due to IL-1beta-induced ROS generation.	ros	200-203	interleukin 1 beta	Homo sapiens	32-40
29470503-9	2018	Likewise, the release of the pro-inflammatory cytokines interleukin-1beta and MIP-1beta and neutrophil transmigration were completely prevented by sevoflurane independent of the onset of sevoflurane administration.	Sevoflurane	147-158	interleukin 1 beta	Homo sapiens	56-73
29467509-4	2018	After activation, both pro-inflammatory and anti-inflammatory cytokines were down-regulated at the mRNA level and certain cytokines (IL-1beta, IL-6 and IL-10) were decreased in the cell supernatant with the addition of magnesium.	Magnesium	219-228	interleukin 1 beta	Homo sapiens	133-141
29339024-5	2018	Human chondrocytes treated with IL-1beta resulted in robust Nrf2/ARE reporter activity, which was inhibited by pretreatment with antioxidants indicating that Nrf2 activity was due to IL-1beta-induced ROS generation.	ros	200-203	interleukin 1 beta	Homo sapiens	183-191
29339024-6	2018	Ectopic expression of Nrf2 significantly suppressed the IL-1beta-induced generation of ROS while Nrf2 knockdown significantly increased the basal as well as IL-1beta-induced ROS levels in OA chondrocytes.	ros	87-90	interleukin 1 beta	Homo sapiens	56-64
29339024-6	2018	Ectopic expression of Nrf2 significantly suppressed the IL-1beta-induced generation of ROS while Nrf2 knockdown significantly increased the basal as well as IL-1beta-induced ROS levels in OA chondrocytes.	ros	174-177	interleukin 1 beta	Homo sapiens	157-165
29339024-7	2018	Further, Nrf2 activation significantly inhibited the IL-1beta-induced activation of extrinsic and intrinsic apoptotic pathways as determined by inhibition of DNA fragmentation, activation of Caspase-3,-8,-9, cleavage of PARP, release of cytochrome-c, suppression of mitochondrial dysfunction and mitochondrial ROS production in OA chondrocytes.	ros	310-313	interleukin 1 beta	Homo sapiens	53-61
28619001-11	2018	RESULTS: IL-1beta induced pronounced expression of COX-2 and iNOS, and stimulated production of prostaglandin E2 and nitric oxide.	Dinoprostone	96-112	interleukin 1 beta	Homo sapiens	9-17
29337193-8	2018	Na2S increased intracellular polysulfide levels, which were enhanced by IL-1beta treatment.	sodium sulfide	0-4	interleukin 1 beta	Homo sapiens	72-80
29337193-8	2018	Na2S increased intracellular polysulfide levels, which were enhanced by IL-1beta treatment.	polysulfide	29-40	interleukin 1 beta	Homo sapiens	72-80
29337193-10	2018	These results suggest that IL-1beta augments H2S-induced [Ca2+]i increases via the conversion of H2S to polysulfides through NO synthesis, but not via changes in the activity and expression of target channels.	Hydrogen Sulfide	45-48	interleukin 1 beta	Homo sapiens	27-35
29337193-10	2018	These results suggest that IL-1beta augments H2S-induced [Ca2+]i increases via the conversion of H2S to polysulfides through NO synthesis, but not via changes in the activity and expression of target channels.	Hydrogen Sulfide	97-100	interleukin 1 beta	Homo sapiens	27-35
29337193-10	2018	These results suggest that IL-1beta augments H2S-induced [Ca2+]i increases via the conversion of H2S to polysulfides through NO synthesis, but not via changes in the activity and expression of target channels.	polysulfide	104-116	interleukin 1 beta	Homo sapiens	27-35
29433511-8	2018	Histamine also dose-dependently stimulated astrocyte activation and subsequent production of glial cell-derived neurotrophic factor (GDNF), whereas it suppressed the secretion of the proinflammatory factors tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Histamine	0-9	interleukin 1 beta	Homo sapiens	251-268
29433511-8	2018	Histamine also dose-dependently stimulated astrocyte activation and subsequent production of glial cell-derived neurotrophic factor (GDNF), whereas it suppressed the secretion of the proinflammatory factors tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Histamine	0-9	interleukin 1 beta	Homo sapiens	270-278
29515581-5	2018	Our findings indicated that inhibition of autophagy with 3-methyladenine and Wortmannin markedly reduced IL-1beta secretion induced by LPS + ATP, as did the disruption of the autophagic flux with Bafilomycin A1 and E64d.	3-methyladenine	57-72	interleukin 1 beta	Homo sapiens	105-113
29515581-5	2018	Our findings indicated that inhibition of autophagy with 3-methyladenine and Wortmannin markedly reduced IL-1beta secretion induced by LPS + ATP, as did the disruption of the autophagic flux with Bafilomycin A1 and E64d.	Wortmannin	77-87	interleukin 1 beta	Homo sapiens	105-113
29515581-5	2018	Our findings indicated that inhibition of autophagy with 3-methyladenine and Wortmannin markedly reduced IL-1beta secretion induced by LPS + ATP, as did the disruption of the autophagic flux with Bafilomycin A1 and E64d.	Adenosine Triphosphate	141-144	interleukin 1 beta	Homo sapiens	105-113
29515581-9	2018	Upon LPS + ATP stimulation, IL-1beta was incorporated to an autophagic compartment, as was revealed by its colocalization with LC3B by confocal microscopy.	Adenosine Triphosphate	11-14	interleukin 1 beta	Homo sapiens	28-36
29343616-9	2018	In addition, rapamycin induction of endothelial-to-mesenchymal transition (EndMT) was potentiated by IL-1beta and efficiently blocked by TGFRIi.	Sirolimus	13-22	interleukin 1 beta	Homo sapiens	101-109
29511440-8	2018	Enzyme-linked immunosorbent assay (ELISA), flow cytometry and western blotting analyses showed that andrographolide could decreased the levels of proinflammatory factors TNF-alpha, IL-1beta, IL-6 and IL-17A in the serum and in the colon tissues, reduced the percentages of Th17 cells in CD4+ cells, and suppressed the levels of IL-23, IL-17A, ROR-gammat (key transcription factor of Th17 cells) and p-STAT3 in the colon tissues.	andrographolide	100-115	interleukin 1 beta	Homo sapiens	181-189
29337193-0	2018	IL-1beta augments H2S-induced increase in intracellular Ca2+ through polysulfides generated from H2S/NO interaction.	Hydrogen Sulfide	18-21	interleukin 1 beta	Homo sapiens	0-8
29337193-0	2018	IL-1beta augments H2S-induced increase in intracellular Ca2+ through polysulfides generated from H2S/NO interaction.	polysulfide	69-81	interleukin 1 beta	Homo sapiens	0-8
29337193-0	2018	IL-1beta augments H2S-induced increase in intracellular Ca2+ through polysulfides generated from H2S/NO interaction.	Hydrogen Sulfide	97-100	interleukin 1 beta	Homo sapiens	0-8
29337193-6	2018	IL-1beta augmented H2S-induced [Ca2+]i increases, which were inhibited by TRPA1 and voltage-dependent L-type Ca2+ channel blockers.	Hydrogen Sulfide	19-22	interleukin 1 beta	Homo sapiens	0-8
28619001-12	2018	Icariin exhibited significant anti-inflammatory effect, inhibiting IL-1beta-induced production of degrading enzymes, as well as extracellular matrix reduction.	icariin	0-7	interleukin 1 beta	Homo sapiens	67-75
28619001-13	2018	Finally, icariin suppressed IL-1beta-induced activation of MAPK- and NF-kappaB-related signaling pathways.	icariin	9-16	interleukin 1 beta	Homo sapiens	28-36
28619001-11	2018	RESULTS: IL-1beta induced pronounced expression of COX-2 and iNOS, and stimulated production of prostaglandin E2 and nitric oxide.	Nitric Oxide	117-129	interleukin 1 beta	Homo sapiens	9-17
29416034-7	2018	Moreover, silencing NLRP3 or ASC by small interfering RNA efficiently suppressed nicotine-induced caspase-1 cleavage, IL-18 and IL-1beta production, and pyroptosis in HAECs.	Nicotine	81-89	interleukin 1 beta	Homo sapiens	128-136
29479354-7	2018	To further understand the differential expression of cytokines/chemokines, we showed that WFA alters the nigericin-induced co-localization of NLRP3 and ASC proteins, thereby inhibiting caspase-1 activation, which is responsible for the cleavage and maturation of pro-inflammatory cytokines IL-1beta and IL-18.	Nigericin	105-114	interleukin 1 beta	Homo sapiens	290-298
29467654-6	2018	ATP acting via P2X7 receptor is the second signal to the inflammasome activation, inducing both maturation and release of pro-inflammatory cytokines, such as IL-1beta and IL-18, and the production of reactive nitrogen and oxygen species.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	158-166
29352570-3	2018	It is now also known that cholesterol crystals are present through all stages of atherosclerosis and can activate the NLRP3 inflammasome within these inflammatory cells to produce interleukin 1beta and interleukin 18 - key mediators in the inflammatory cascade that drive plaque progression and instability.	Cholesterol	26-37	interleukin 1 beta	Homo sapiens	180-197
29456507-5	2018	Results: Results of RT-PCR indicated that after the 12-week intervention, compared to the placebo, vitamin D supplementation downregulated gene expression of interleukin (IL)-1beta (P = 0.02), tumor necrosis factor alpha (TNF-alpha) (P = 0.02) and interferon gamma (IFN-gamma) (P = 0.03) in PBMCs of diabetic HD patients.	Vitamin D	99-108	interleukin 1 beta	Homo sapiens	158-180
29266859-9	2018	Furthermore, GO-triggered IL-1 beta production requires NADPH oxidase-generated reactive oxygen species and cellular uptake of GO and is accompanied by cathepsin B release and K+ efflux.	Reactive Oxygen Species	80-103	interleukin 1 beta	Homo sapiens	26-35
29266859-9	2018	Furthermore, GO-triggered IL-1 beta production requires NADPH oxidase-generated reactive oxygen species and cellular uptake of GO and is accompanied by cathepsin B release and K+ efflux.	graphene oxide	13-15	interleukin 1 beta	Homo sapiens	26-35
29196238-0	2018	TGF-beta synergizes with ML264 to block IL-1beta-induced matrix degradation mediated by Kruppel-like factor 5 in the nucleus pulposus.	ML264	25-30	interleukin 1 beta	Homo sapiens	40-48
29196238-5	2018	Therefore, a KLF5 inhibitor ML264 was further proved to synergize with TGF-beta to attenuate IL-1beta-induced intervertebral disc degeneration.	ML264	28-33	interleukin 1 beta	Homo sapiens	93-101
29224225-9	2018	Our results indicate that IL-1beta derived from TAMs suppresses 15-PGDH expression in PDAC cells, resulting in poor prognosis of PDAC patients.	Tamoxifen	48-52	interleukin 1 beta	Homo sapiens	26-34
29291551-6	2018	In the current study, our results indicate that Ghrelin reduced IL-1beta-induced expression of MMP-3, MMP-13, ADAMTS-4 and ADAMTS-5 in a concentration-dependent manner.	Ghrelin	48-55	interleukin 1 beta	Homo sapiens	64-72
29291551-7	2018	Notably, Ghrelin ameliorated IL-1beta-induced degradation of type II collagen and aggrecan.	Ghrelin	9-16	interleukin 1 beta	Homo sapiens	29-37
29117589-6	2018	Additionally, long-term exposure of MC-LR at low concentration remarkably promoted the expression of NF-kappaB p65, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6 in the cells, suggesting that long-term MC-LR exposure at low concentration can induce inflammatory reaction to HepG2 cells, which might account for MC-induced human hepatitis.	cyanoginosin LR	36-41	interleukin 1 beta	Homo sapiens	140-148
29117589-6	2018	Additionally, long-term exposure of MC-LR at low concentration remarkably promoted the expression of NF-kappaB p65, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6 in the cells, suggesting that long-term MC-LR exposure at low concentration can induce inflammatory reaction to HepG2 cells, which might account for MC-induced human hepatitis.	Methylcholanthrene	36-38	interleukin 1 beta	Homo sapiens	140-148
28988346-13	2018	Palmitate or C2 ceramide induced ER stress in macrophages as well as increased expression of TXNIP, NLRP3 and IL-1beta.	Palmitates	0-9	interleukin 1 beta	Homo sapiens	110-118
28988346-13	2018	Palmitate or C2 ceramide induced ER stress in macrophages as well as increased expression of TXNIP, NLRP3 and IL-1beta.	Ceramides	16-24	interleukin 1 beta	Homo sapiens	110-118
29434821-6	2018	Preconditioning with physiological 5% CS for 30, 60 and 120 min was demonstrated to significantly attenuate the release of pathologically mechanical stretch-induced early pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-8) in alveolar epithelial cells (P&lt;0.05) and significantly reduce the expression of NF-kappaB (P&lt;0.05).	Cesium	38-40	interleukin 1 beta	Homo sapiens	210-218
29434821-8	2018	In the second set of experiments, it was demonstrated that mechanical stretch-induced release of TNF-alpha, IL-1beta and IL-8 was significantly inhibited by both PDTC pretreatment and 5% CS pretreatment alone (all P&lt;0.05).	Cesium	187-189	interleukin 1 beta	Homo sapiens	108-116
28946308-3	2018	AAMP-A70 increases macrophage phagocytosis and secretion of NO, ROS, TNF-alpha, IL-6 and IL-1beta.	aamp-a70	0-8	interleukin 1 beta	Homo sapiens	89-97
28800925-0	2018	Resveratrol increases phagocytosis and lipopolysaccharide-induced interleukin-1beta production, but decreases surface expression of Toll-like receptor 2 in THP-1 monocytes.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	66-83
28800925-4	2018	Resveratrol aglycone increased phagocytosis at concentrations of 5, 10, and 15muM and LPS-induced IL-1beta production at concentrations of 10 and 15muM.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	98-106
29236553-5	2018	lipopolysaccharide co-treatment with progesterone significantly decreased the bacterial endotoxin-induced IL-1beta, TNF-alpha, IL-6, IL-8, and MIP-1alpha secretion.	Progesterone	37-49	interleukin 1 beta	Homo sapiens	106-114
29198726-6	2018	Moreover, a significant inhibition of the inflammasome activation was observed in neopterin pre-conditioned human astrocytes, when challenged with LPS, by reducing IL-1beta, caspase-1 and ASC expression or content, components of the NLRP3 inflammasome.	Neopterin	82-91	interleukin 1 beta	Homo sapiens	164-172
29310108-1	2018	OBJECTIVE: This research aimed to study the anti-inflammatory and immunomodulatory effects of guluronic acid (G2013) on gene expression of TLR4, MyD88, SHIP1, SOCS1, NF-kappaB, and assessment of the level of IL-1beta as a pro-inflammatory cytokine in HEK-Blue hTLR4 cell line.	guluronic acid	94-108	interleukin 1 beta	Homo sapiens	208-216
29253822-7	2018	Cell aggregation as well as the down-regulation of IL-1beta, TNFalpha and PGE2 caused by the culture on collagen I-coated surface were suppressed by ROS donor, tert-butylhydroperoxide (tBHP).	Reactive Oxygen Species	149-152	interleukin 1 beta	Homo sapiens	51-59
29253822-7	2018	Cell aggregation as well as the down-regulation of IL-1beta, TNFalpha and PGE2 caused by the culture on collagen I-coated surface were suppressed by ROS donor, tert-butylhydroperoxide (tBHP).	tert-Butylhydroperoxide	160-183	interleukin 1 beta	Homo sapiens	51-59
29253822-7	2018	Cell aggregation as well as the down-regulation of IL-1beta, TNFalpha and PGE2 caused by the culture on collagen I-coated surface were suppressed by ROS donor, tert-butylhydroperoxide (tBHP).	tert-Butylhydroperoxide	185-189	interleukin 1 beta	Homo sapiens	51-59
28646347-0	2018	Alendronate treatment induces IL-1B expression and apoptosis in glioblastoma cell line.	Alendronate	0-11	interleukin 1 beta	Homo sapiens	30-35
29274626-3	2018	The results showed that LP significantly decreased the LPS-induced overexpression levels of pro-inflammatory cytokines including IL-1beta, IL-15, TNF-alpha and MIP-1alpha, through the NF-kappaB pathway.	leucylproline	24-26	interleukin 1 beta	Homo sapiens	129-137
29274344-0	2018	Calcium phosphate particles stimulate interleukin-1beta release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release.	calcium phosphate	0-17	interleukin 1 beta	Homo sapiens	38-55
29207019-0	2018	Stromal-epithelial lactate shuttle induced by tumor-derived interleukin-1beta promotes cell proliferation in oral squamous cell carcinoma.	Lactic Acid	19-26	interleukin 1 beta	Homo sapiens	60-77
29207019-3	2018	In the present study, anaerobic glycolysis of cancer-associated fibroblasts (CAFs) was evaluated and the role of IL-1beta in regulating stromal-epithelial lactate shuttle was determined.	Lactic Acid	155-162	interleukin 1 beta	Homo sapiens	113-121
29207019-11	2018	These results indicate that tumor-derived IL-1beta enhanced stromal glycolysis and induced one-way lactate flow from the tumor mesenchyme to transformed epithelium, which promotes OSCC proliferation.	Lactic Acid	99-106	interleukin 1 beta	Homo sapiens	42-50
29232311-9	2018	Concurrent treatment with lithium and low-dose colchicine could facilitate the responsiveness of bipolar patients to lithium by reducing leukocyte tissue emigration, the release of neutrophil elastase, and the release of leukocyte pro-inflammatory cytokines such as IL-1beta that are regulated by the NLRP3 inflammasome assembly complex.	Lithium	26-33	interleukin 1 beta	Homo sapiens	266-274
29232311-9	2018	Concurrent treatment with lithium and low-dose colchicine could facilitate the responsiveness of bipolar patients to lithium by reducing leukocyte tissue emigration, the release of neutrophil elastase, and the release of leukocyte pro-inflammatory cytokines such as IL-1beta that are regulated by the NLRP3 inflammasome assembly complex.	Colchicine	47-57	interleukin 1 beta	Homo sapiens	266-274
29232311-9	2018	Concurrent treatment with lithium and low-dose colchicine could facilitate the responsiveness of bipolar patients to lithium by reducing leukocyte tissue emigration, the release of neutrophil elastase, and the release of leukocyte pro-inflammatory cytokines such as IL-1beta that are regulated by the NLRP3 inflammasome assembly complex.	Lithium	117-124	interleukin 1 beta	Homo sapiens	266-274
29207166-7	2018	In addition, PPS treatment significantly inhibited HG-stimulated p38 MAPK and nuclear factor-kappaB activation, and reduced the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6.	Pentosan Sulfuric Polyester	13-16	interleukin 1 beta	Homo sapiens	207-229
29274344-7	2018	The SYK inhibitor R406 reduced IL-1beta release and caspase-1 activation in CaP particle-treated VSMCs, indicating that SYK activation occurs upstream of and is required for caspase-1 activation.	R406	18-22	interleukin 1 beta	Homo sapiens	31-39
29274344-7	2018	The SYK inhibitor R406 reduced IL-1beta release and caspase-1 activation in CaP particle-treated VSMCs, indicating that SYK activation occurs upstream of and is required for caspase-1 activation.	vsmcs	97-102	interleukin 1 beta	Homo sapiens	31-39
29274344-9	2018	Furthermore, CaP particle treatment stimulated exosome secretion by VSMCs in a SYK-dependent manner, while the exosome-release inhibitor spiroepoxide reduced IL-1beta release.	spiroepoxide	137-149	interleukin 1 beta	Homo sapiens	158-166
29274344-10	2018	CONCLUSIONS: CaP particles stimulate SYK and caspase-1 activation in VSMCs, leading to the release of IL-1beta, at least in part via exosomes.	calcium phosphate	13-16	interleukin 1 beta	Homo sapiens	102-110
29207123-5	2018	The present study demonstrated that NLRP3 inflammasome and IL-1beta were activated in PMA-induced macrophages in a time-dependent manner, whereas berberine significantly inhibited their expression in a dose-dependent manner in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	86-89	interleukin 1 beta	Homo sapiens	59-67
29248877-0	2018	Fatty acid oxidation contributes to IL-1beta secretion in M2 macrophages and promotes macrophage-mediated tumor cell migration.	Fatty Acids	0-10	interleukin 1 beta	Homo sapiens	36-44
29248877-6	2018	Using etomoxir and siRNA to inhibit FAO and palmitate to enhance FAO, we showed that FAO was responsible for the up-regulated secretion of IL-1beta and, thus, the pro-migratory effect in M2 MDMs.	etomoxir	6-14	interleukin 1 beta	Homo sapiens	139-147
29248877-6	2018	Using etomoxir and siRNA to inhibit FAO and palmitate to enhance FAO, we showed that FAO was responsible for the up-regulated secretion of IL-1beta and, thus, the pro-migratory effect in M2 MDMs.	Palmitates	44-53	interleukin 1 beta	Homo sapiens	139-147
29248877-7	2018	In addition, we proved that IL-1beta induction was reactive oxygen species and NLRP3-dependent.	Reactive Oxygen Species	51-74	interleukin 1 beta	Homo sapiens	28-36
29257274-7	2018	In addition, the results demonstrated that miR-33 impaired mitochondrial oxygen consumption rates, resulting in the accumulation of cellular reactive oxygen species, which stimulated NLRP3 expression, caspase-1 activity and IL-1beta secretion.	Oxygen	73-79	interleukin 1 beta	Homo sapiens	224-232
28084593-10	2018	Furthermore, PB induced anti-inflammatory effects by abolishing the H2O2-dependent activation of the nuclear factor-kappaB (NF-kappaB) and upregulation of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	pinocembrin	13-15	interleukin 1 beta	Homo sapiens	155-172
29257274-7	2018	In addition, the results demonstrated that miR-33 impaired mitochondrial oxygen consumption rates, resulting in the accumulation of cellular reactive oxygen species, which stimulated NLRP3 expression, caspase-1 activity and IL-1beta secretion.	Reactive Oxygen Species	141-164	interleukin 1 beta	Homo sapiens	224-232
29257281-0	2018	Paeoniflorin inhibits IL-1beta-induced expression of inflammatory mediators in human osteoarthritic chondrocyte.	peoniflorin	0-12	interleukin 1 beta	Homo sapiens	22-30
29257281-5	2018	The results of the present study determined that PF inhibited the production of nitric oxide and prostaglandin E2 induced by IL-1beta, and the expression of inducible nitric oxide synthase and cyclooxygenase-2 in chondrocytes.	peoniflorin	49-51	interleukin 1 beta	Homo sapiens	125-133
29257281-5	2018	The results of the present study determined that PF inhibited the production of nitric oxide and prostaglandin E2 induced by IL-1beta, and the expression of inducible nitric oxide synthase and cyclooxygenase-2 in chondrocytes.	Nitric Oxide	80-92	interleukin 1 beta	Homo sapiens	125-133
29257281-5	2018	The results of the present study determined that PF inhibited the production of nitric oxide and prostaglandin E2 induced by IL-1beta, and the expression of inducible nitric oxide synthase and cyclooxygenase-2 in chondrocytes.	Dinoprostone	97-113	interleukin 1 beta	Homo sapiens	125-133
28656526-11	2018	Melatonin reduced IL1beta and HA in GO and control fibroblasts, and IFNgamma only in GO fibroblasts.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	18-25
28084593-10	2018	Furthermore, PB induced anti-inflammatory effects by abolishing the H2O2-dependent activation of the nuclear factor-kappaB (NF-kappaB) and upregulation of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	pinocembrin	13-15	interleukin 1 beta	Homo sapiens	174-182
29358306-6	2018	In human primary myometrial cells transfected with PARK7 siRNA (siPARK7), there was a significant decrease in IL1B, TNF, fsl-1 and poly(I:C)-induced expression of pro-inflammatory cytokine IL6, chemokines (CXCL8, CCL2), adhesion molecule ICAM1, prostaglandin PGF2alpha and its receptor PTGFR.	Prostaglandins	245-258	interleukin 1 beta	Homo sapiens	110-114
29358306-6	2018	In human primary myometrial cells transfected with PARK7 siRNA (siPARK7), there was a significant decrease in IL1B, TNF, fsl-1 and poly(I:C)-induced expression of pro-inflammatory cytokine IL6, chemokines (CXCL8, CCL2), adhesion molecule ICAM1, prostaglandin PGF2alpha and its receptor PTGFR.	Dinoprost	259-268	interleukin 1 beta	Homo sapiens	110-114
29168867-8	2018	In this study, we found that phloretin significantly inhibited the IL-1beta-induced production of NO, PGE2, TNF-alpha, and IL-6, the expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5, and the degradation of aggrecan and collagen-II in human OA chondrocytes.	Phloretin	29-38	interleukin 1 beta	Homo sapiens	67-75
29386662-6	2018	DHA-treated breast cancer cells triggered increased caspase-1and gasdermin D activation, enhanced IL-1beta secretion, translocated HMGB1 towards the cytoplasm, and membrane pore formation when compared to untreated cells, suggesting DHA induces pyroptosis programmed cell death in breast cancer cells.	Docosahexaenoic Acids	0-3	interleukin 1 beta	Homo sapiens	98-106
29168867-8	2018	In this study, we found that phloretin significantly inhibited the IL-1beta-induced production of NO, PGE2, TNF-alpha, and IL-6, the expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5, and the degradation of aggrecan and collagen-II in human OA chondrocytes.	Dinoprostone	102-106	interleukin 1 beta	Homo sapiens	67-75
29168867-9	2018	Furthermore, phloretin dramatically suppressed the IL-1beta-stimulated phosphorylation of PI3K/Akt and activation of NF-kappaB in human OA chondrocytes.	Phloretin	13-22	interleukin 1 beta	Homo sapiens	51-59
29568569-5	2018	Results: One such material, synthesized from chondroitin sulfate type A and serotonin in the presence of Cu2+ was found to affect the release of IL-1beta and IL-6 cytokines from immune cells.	Chondroitin Sulfates	45-64	interleukin 1 beta	Homo sapiens	145-153
29568569-5	2018	Results: One such material, synthesized from chondroitin sulfate type A and serotonin in the presence of Cu2+ was found to affect the release of IL-1beta and IL-6 cytokines from immune cells.	Serotonin	76-85	interleukin 1 beta	Homo sapiens	145-153
29568569-5	2018	Results: One such material, synthesized from chondroitin sulfate type A and serotonin in the presence of Cu2+ was found to affect the release of IL-1beta and IL-6 cytokines from immune cells.	cupric ion	105-109	interleukin 1 beta	Homo sapiens	145-153
28962868-9	2018	HaCaT cells pretreated/treated with FITOPROT also showed normal expression of TNF-R1 and NF-kappaB inflammatory proteins and decreased levels of pro-inflammatory cytokines (TNF, IL-1beta, IL-6 and IL-8).	fitoprot	36-44	interleukin 1 beta	Homo sapiens	178-186
29348392-4	2018	The senescence-associated beta-galactosidase activity, the protein expression of P16 and P21, and inflammatory-related marker gene levels IL-1beta, IL-6, and TNF-alpha were increased in bleomycin-treated AFSCs in a dose-dependent manner.	Bleomycin	186-195	interleukin 1 beta	Homo sapiens	138-146
29348392-5	2018	Rapamycin treatment decreased the gene expression of MMP-3, MMP-13, IL-1beta, IL-6, TNF-alpha, and protein levels of P16 and P21 in bleomycin-treated AFSCs.	Sirolimus	0-9	interleukin 1 beta	Homo sapiens	68-76
29348392-5	2018	Rapamycin treatment decreased the gene expression of MMP-3, MMP-13, IL-1beta, IL-6, TNF-alpha, and protein levels of P16 and P21 in bleomycin-treated AFSCs.	Bleomycin	132-141	interleukin 1 beta	Homo sapiens	68-76
29195811-5	2018	Cell- and liposome-based assays demonstrated that GSDMD pores were required for IL-1beta transport across an intact lipid bilayer.	Lipid Bilayers	116-129	interleukin 1 beta	Homo sapiens	80-88
29258746-6	2018	Meanwhile, silica persistently activated NLRP3 inflammasome as indicated by continuously elevated extracellular levels of interleukin-1beta (IL-1beta) and IL-18.	Silicon Dioxide	11-17	interleukin 1 beta	Homo sapiens	122-139
29258746-6	2018	Meanwhile, silica persistently activated NLRP3 inflammasome as indicated by continuously elevated extracellular levels of interleukin-1beta (IL-1beta) and IL-18.	Silicon Dioxide	11-17	interleukin 1 beta	Homo sapiens	141-149
29269075-6	2018	Monocytes treated with Docetaxel also displayed an elevated secretion of IL-8 and IL-1beta, but did not promote generation of monocytic myeloid-derived suppressor cells.	Docetaxel	23-32	interleukin 1 beta	Homo sapiens	82-90
28595944-5	2018	CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs).	Tryptophan	84-94	interleukin 1 beta	Homo sapiens	49-57
29320557-10	2018	Two well-known ligands for AHR (TCDD and BaP) induced mRNA expression of IL1B and IL6 in an ERalpha-negative breast tumor cell line.	Benzo(a)pyrene	41-44	interleukin 1 beta	Homo sapiens	73-77
29956204-11	2018	In both experimental and human NASH, livers contain cholesterol crystals which are a second signal for NLRP3 activation; this causes interleukin (IL)-1beta and IL18 secretion to attract and activate macrophages and neutrophils.	Cholesterol	52-63	interleukin 1 beta	Homo sapiens	133-155
29434478-5	2018	Internalization of bacteria or stimulation with lipooligosaccharide (LOS) specifically induced pyroptosis in MDMs and increased secretion of IL-1beta.	lipid-linked oligosaccharides	48-67	interleukin 1 beta	Homo sapiens	141-149
29434478-5	2018	Internalization of bacteria or stimulation with lipooligosaccharide (LOS) specifically induced pyroptosis in MDMs and increased secretion of IL-1beta.	lipid-linked oligosaccharides	69-72	interleukin 1 beta	Homo sapiens	141-149
29521042-10	2018	Additional application of dexamethasone to SCP-1 cells further increased the RANKL/OPG ratio 3-fold, but decreased IL-6 and IL-1beta expression to 10% and 50%, respectively.	Dexamethasone	26-39	interleukin 1 beta	Homo sapiens	124-132
28595944-5	2018	CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs).	Kynurenine	180-190	interleukin 1 beta	Homo sapiens	49-57
28595944-5	2018	CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs).	Kynurenine	192-195	interleukin 1 beta	Homo sapiens	49-57
28595944-5	2018	CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs).	Tryptophan	207-217	interleukin 1 beta	Homo sapiens	49-57
29164996-10	2018	Elevation of intracellular C1P by exogenous C1P treatment (instead of CPTP inhibition) also induced autophagy and IL1B release.	ceramide 1-phosphate	27-30	interleukin 1 beta	Homo sapiens	114-118
29164996-10	2018	Elevation of intracellular C1P by exogenous C1P treatment (instead of CPTP inhibition) also induced autophagy and IL1B release.	ceramide 1-phosphate	44-47	interleukin 1 beta	Homo sapiens	114-118
29129744-3	2018	In this study, the diterpenoids (pekinenin A, pekinenin C, pekinenin F, pekinenin G, yuexiandajisu A, (-)-(1S)-15-hydroxy-18-carboxycembrene) elevated the expression of interleukin 1 beta and tumor necrosis factor alpha in a dose-dependent manner at doses of 6.25, 12.5, and 25 muM in RAW264.7 monocultures.	(-)-(1S)-15-hydroxy-18-carboxycembrene	106-140	interleukin 1 beta	Homo sapiens	169-219
30526472-8	2018	Colchicine has direct antiinflammatory effects by inhibiting critical inflammatory signaling networks as the inflammasome, pro-inflammatory cytokines, and expression of adhesion molecules, preventing both local chemoattraction of inflammatory cells such as neutrophils and systemic inflammation including the decrease of the release of IL-1beta by the neutrophils.	Colchicine	0-10	interleukin 1 beta	Homo sapiens	336-344
30270322-4	2018	Acteoside dose- and time-dependently augmented the activation of the precursor of MMP-2 (proMMP-2/progelatinase A) in untreated- and interleukin-1beta-treated NHDF, while the alteration of the MMP-2 gene expression was negligible.	acteoside	0-9	interleukin 1 beta	Homo sapiens	133-150
30270322-4	2018	Acteoside dose- and time-dependently augmented the activation of the precursor of MMP-2 (proMMP-2/progelatinase A) in untreated- and interleukin-1beta-treated NHDF, while the alteration of the MMP-2 gene expression was negligible.	nhdf	159-163	interleukin 1 beta	Homo sapiens	133-150
30068872-11	2018	Furthermore, DBM effectively inhibited the expression of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta), IL-6, and monocyte chemoattractant protein-1 (MCP-1).	dibenzoylmethane	13-16	interleukin 1 beta	Homo sapiens	133-151
30068872-11	2018	Furthermore, DBM effectively inhibited the expression of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta), IL-6, and monocyte chemoattractant protein-1 (MCP-1).	dibenzoylmethane	13-16	interleukin 1 beta	Homo sapiens	153-161
28963000-2	2018	We have previously shown that severe stress exposure in a preclinical animal model of the disorder, stress-enhanced fear learning (SEFL), is associated with an increase in hippocampal interleukin-1beta (IL-1beta) and that blocking central IL-1 after the severe stress prevents the development of SEFL.	sefl	131-135	interleukin 1 beta	Homo sapiens	184-201
28963000-2	2018	We have previously shown that severe stress exposure in a preclinical animal model of the disorder, stress-enhanced fear learning (SEFL), is associated with an increase in hippocampal interleukin-1beta (IL-1beta) and that blocking central IL-1 after the severe stress prevents the development of SEFL.	sefl	131-135	interleukin 1 beta	Homo sapiens	203-211
30064139-10	2018	RESULTS: Zedoarondiol attenuated HUVECs injury, up-regulated SOD activity, suppressed formation of MDA and ROS, and secretion and protein expression of IL-1beta, TNF-alpha, and MCP-1 in injured HUVECs induced by ox-LDL.	zedoarondiol	9-21	interleukin 1 beta	Homo sapiens	152-160
30184535-0	2018	Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.	butein	0-6	interleukin 1 beta	Homo sapiens	93-101
30138921-9	2018	RESULTS: Here, we clarified that ethanol treatment could cause cell DNA damage, activate caspase-1, and promote the generation and release of IL-1beta and IL-18.	Ethanol	33-40	interleukin 1 beta	Homo sapiens	142-150
30138927-11	2018	It also prevented IL-1beta release after exposure of primed cells to MG-132 and BafA.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	69-75	interleukin 1 beta	Homo sapiens	18-26
30138927-11	2018	It also prevented IL-1beta release after exposure of primed cells to MG-132 and BafA.	bafilomycin A1	80-84	interleukin 1 beta	Homo sapiens	18-26
30138927-14	2018	Instead, MG-132 triggered ROS production already 30 min after exposure, but treatment with antioxidants blocking NADPH oxidase and mitochondria-derived ROS significantly prevented IL-1beta release after this activating signal.	Reactive Oxygen Species	152-155	interleukin 1 beta	Homo sapiens	180-188
30121641-10	2018	In addition, inhibition of IL-1beta/miR-144-3p/WT1D and IL-1beta/NF-kappaB/COX-2/HIF-1alpha pathways using miR-144-3p mimic and Celecoxib, respectively, displayed synergistic suppressive effect on cell proliferation in LUAD.	Celecoxib	128-137	interleukin 1 beta	Homo sapiens	27-35
30121641-10	2018	In addition, inhibition of IL-1beta/miR-144-3p/WT1D and IL-1beta/NF-kappaB/COX-2/HIF-1alpha pathways using miR-144-3p mimic and Celecoxib, respectively, displayed synergistic suppressive effect on cell proliferation in LUAD.	Celecoxib	128-137	interleukin 1 beta	Homo sapiens	56-64
30184535-9	2018	Butein increased the phosphorylation of AMPKalphaThr-172, TSC2Ser-1387 and ULK1Ser-317 and inhibited the phosphorylation of mTORSer-2448 and its downstream target p70S6K and increased autophagy flux that correlated with the suppression of the IL-1beta mediated expression of IL-6 in normal and OA chondrocytes.	butein	0-6	interleukin 1 beta	Homo sapiens	243-251
30184535-10	2018	In OA chondrocytes with siRNA-mediated knockdown of ATG5 expression, treatment with Butein failed to activate autophagy and abrogated the suppression of IL-1beta induced IL-6 expression.	butein	84-90	interleukin 1 beta	Homo sapiens	153-161
30355931-12	2018	CONCLUSION: The paclitaxel+hirudin compound promotes MyD88 degradation in the TLR4/MyD88/NF-kappaB pathway to reduce the activity of TLR4 and NF-kappaB p65 and to weaken the LPS-initiated inflammatory reactions of IL-1beta, IL-6, and TNF-alpha.	Paclitaxel	16-26	interleukin 1 beta	Homo sapiens	214-222
30261504-0	2018	Nicotinamide Phosphoribosyltransferase Inhibitor APO866 Prevents IL-1beta-Induced Human Nucleus Pulposus Cell Degeneration via Autophagy.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	49-55	interleukin 1 beta	Homo sapiens	65-73
30261504-4	2018	Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the first step in the biosynthesis of nicotinamide adenine dinucleotide (NAD) and is known to be induced by IL-1beta.	NAD	95-128	interleukin 1 beta	Homo sapiens	165-173
30261504-4	2018	Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the first step in the biosynthesis of nicotinamide adenine dinucleotide (NAD) and is known to be induced by IL-1beta.	NAD	130-133	interleukin 1 beta	Homo sapiens	165-173
30261504-13	2018	However, the Nampt inhibitor APO866 blocked IL-1beta induction, and the knockdown of Nampt expression increased the expression of ECM proteins that were inhibited by IL-1beta.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	29-35	interleukin 1 beta	Homo sapiens	44-52
30504721-5	2018	RESULTS: The results revealed that IL-1beta significantly increased the production of NO, PGE2, MMP1, MMP3, and MMP13.	Dinoprostone	90-94	interleukin 1 beta	Homo sapiens	35-43
30466085-11	2018	miR-320c overexpression and CDK6 inhibition repressed IL-1beta-induced expression of inflammatory factors and regulated the NF-kB signaling pathway.	mir-320c	0-8	interleukin 1 beta	Homo sapiens	54-62
30476915-8	2018	RESULTS: The results showed that DSS markedly downregulated miR-135a expression (P&lt; 0.05) and induced inflammatory response in Caco-2 and HT-29 cells evidenced by the up regulations and productions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) (P&lt; 0.05).	dss	33-36	interleukin 1 beta	Homo sapiens	204-221
30476915-8	2018	RESULTS: The results showed that DSS markedly downregulated miR-135a expression (P&lt; 0.05) and induced inflammatory response in Caco-2 and HT-29 cells evidenced by the up regulations and productions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) (P&lt; 0.05).	dss	33-36	interleukin 1 beta	Homo sapiens	223-231
30476915-9	2018	Transfection with miR-135a mimic significantly alleviated DSS-induced upregulation and productions of IL-1beta and TNF-alpha in Caco-2 and HT-29 cells (P&lt; 0.05).	dss	58-61	interleukin 1 beta	Homo sapiens	102-110
29763932-8	2018	RESULTS: In OA chondrocytes stimulated with IL-1beta, microvesicles and exosomes reduced the production of inflammatory mediators tumor necrosis factor-alpha, IL-6, PGE2 and NO.	Dinoprostone	165-169	interleukin 1 beta	Homo sapiens	44-52
29402837-16	2018	In addition, the results revealed that the expression of CCL5, IL-1beta and TNF-alpha was increased in the high-glucose group, and that the NO produced by HUVECs decreased due to hyperglycemia; however, co-culture with OMT or A2B siRNA abolished these effects.	Glucose	112-119	interleukin 1 beta	Homo sapiens	63-71
29402837-16	2018	In addition, the results revealed that the expression of CCL5, IL-1beta and TNF-alpha was increased in the high-glucose group, and that the NO produced by HUVECs decreased due to hyperglycemia; however, co-culture with OMT or A2B siRNA abolished these effects.	oxymatrine	219-222	interleukin 1 beta	Homo sapiens	63-71
29214547-1	2018	The NLRP3-interleukin1beta (IL1beta) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation.	Uric Acid	70-86	interleukin 1 beta	Homo sapiens	28-35
30361718-7	2018	Las concentraciones sericas de IL-1beta disminuyeron unicamente con la dieta hipocalorica normoproteica (p = 0.02).	Lanthanum	0-3	interleukin 1 beta	Homo sapiens	31-39
29214547-1	2018	The NLRP3-interleukin1beta (IL1beta) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation.	Uric Acid	88-91	interleukin 1 beta	Homo sapiens	28-35
29133043-5	2018	Further characterization revealed that AN-03 and AN-04 had greater potency than BBG and A740003 in inhibiting dye uptake, IL-1beta release, and carrageenan-induced paw edema in vivo.	(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)	88-95	interleukin 1 beta	Homo sapiens	122-130
29037476-9	2018	ZZrOE showed less cytotoxicity because of the lower amount of Zn ions released from ZOE while showing sustained inhibition of inflammatory marker (e.g., interleukin 1beta, 6 and 8) mRNA levels.	zzroe	0-5	interleukin 1 beta	Homo sapiens	153-179
29186698-9	2018	In addition, atorvastatin dose-dependently decreased basal and status epilepticus-induced levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (INF-gamma) and increased interleukin-10 (IL-10) levels in the hippocampus and cerebral cortex.	Atorvastatin	13-25	interleukin 1 beta	Homo sapiens	100-117
29186698-9	2018	In addition, atorvastatin dose-dependently decreased basal and status epilepticus-induced levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (INF-gamma) and increased interleukin-10 (IL-10) levels in the hippocampus and cerebral cortex.	Atorvastatin	13-25	interleukin 1 beta	Homo sapiens	119-127
29217270-6	2018	Kafirin at 100 mug/mL reduced the production of pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha by 28.3%, 74.0%, and 81.4%, respectively.	kafirin	0-7	interleukin 1 beta	Homo sapiens	75-83
30392493-8	2018	Under the influence of quercetin, levels of IL-1beta and TNF-alpha were reduced and IL-10 levels tended to decrease.	Quercetin	23-32	interleukin 1 beta	Homo sapiens	44-52
28433688-3	2018	OBJECTIVE: We set out to define the role of 1alpha,25-dihydroxy vitamin D3 (1,25D) in regulating functional responses of human mucosal ILC3s to IL-23 plus IL-1beta stimulation.	Calcitriol	44-74	interleukin 1 beta	Homo sapiens	155-163
30618316-6	2018	IL-1beta release from carbon particle-exposures was decreased by the presence of Ag in both cell models.	Carbon	22-28	interleukin 1 beta	Homo sapiens	0-8
29297432-2	2018	Some of the beneficial effects of vitamin D might be mediated through interleukin-1beta (IL-1beta).	Vitamin D	34-43	interleukin 1 beta	Homo sapiens	70-87
29297432-2	2018	Some of the beneficial effects of vitamin D might be mediated through interleukin-1beta (IL-1beta).	Vitamin D	34-43	interleukin 1 beta	Homo sapiens	89-97
29229137-13	2018	CONCLUSIONS: MgSO4 inhibits NLRP3 inflammasome, IL-1beta upregulation, and pyroptosis.	Magnesium Sulfate	13-18	interleukin 1 beta	Homo sapiens	48-56
29148173-6	2018	We found that metformin ameliorated the induction of colitis and reduced the levels of pro-inflammatory cytokines IL-6, TNF-a and IL-1beta.	Metformin	14-23	interleukin 1 beta	Homo sapiens	130-138
29482476-6	2018	In addition, PFDA and PFUnA enhanced gene expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 by activation of nuclear factor-kappaB in IgE-stimulated mast cells.	perfluorodecanoic acid	13-17	interleukin 1 beta	Homo sapiens	127-149
26831858-14	2018	The IL-1ra/IL-1beta ratio in all BMC samples was above the value reported to inhibit IL-1beta.	bmc	33-36	interleukin 1 beta	Homo sapiens	11-19
28792854-10	2018	Phytosterol treatment alone did not activate inflammation in Kupffer cells but, combined with LPS, synergistically increased interleukin 1beta production.	Phytosterols	0-11	interleukin 1 beta	Homo sapiens	125-142
29408825-8	2018	In particular, TSP-1 contributed to the action of PPARdelta in the regulation of H2O2-induced interleukin-1beta expression.	Hydrogen Peroxide	81-85	interleukin 1 beta	Homo sapiens	94-111
26831858-14	2018	The IL-1ra/IL-1beta ratio in all BMC samples was above the value reported to inhibit IL-1beta.	bmc	33-36	interleukin 1 beta	Homo sapiens	85-93
30270727-9	2018	injections of TAK-242 (a TLR4-specific antagonist) or 4",6-diamidino-2-phenylindole-dihydrochloride (PDTC, a nuclear factor-kappa B activation inhibitor) dose dependently alleviated plantar incision-induced mechanical allodynia and thermal hyperalgesia and inhibited the increased expressions of p-p65, tumor necrosis factor-alpha, and interleukin-1 beta in DRG.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	14-21	interleukin 1 beta	Homo sapiens	336-354
28653238-6	2018	Furthermore, we found that ghrelin effectively suppressed TNF-alpha-induced inflammatory factors" (including ICAM-1, VCAM-1, MCP-1, and IL-1beta) expression through inhibiting AMPK phosphorylation and p65 expression both in HUVEC and THP-1.	Ghrelin	27-34	interleukin 1 beta	Homo sapiens	136-144
28744817-7	2018	However, the effects of inhibition of PRMT1-mediated IL-1beta-induced cartilage matrix degradation and inflammatory response in OA chondrocytes were obviously abolished by Hedgehog agonist Purmorphamine (Pur).	purmorphamine	189-202	interleukin 1 beta	Homo sapiens	53-61
28083817-6	2018	SH-SY5Y cells were pretreated for 12 h with CA at 1 muM before exposure to PQ for further 24 h. CA suppressed the PQ-induced alterations on the levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2 (COX-2) through a mechanism involving the activation of the Nrf2/HO-1 axis.	Paraquat	114-116	interleukin 1 beta	Homo sapiens	154-171
28083817-6	2018	SH-SY5Y cells were pretreated for 12 h with CA at 1 muM before exposure to PQ for further 24 h. CA suppressed the PQ-induced alterations on the levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2 (COX-2) through a mechanism involving the activation of the Nrf2/HO-1 axis.	Paraquat	114-116	interleukin 1 beta	Homo sapiens	173-181
30270727-9	2018	injections of TAK-242 (a TLR4-specific antagonist) or 4",6-diamidino-2-phenylindole-dihydrochloride (PDTC, a nuclear factor-kappa B activation inhibitor) dose dependently alleviated plantar incision-induced mechanical allodynia and thermal hyperalgesia and inhibited the increased expressions of p-p65, tumor necrosis factor-alpha, and interleukin-1 beta in DRG.	dihydrochloride	84-99	interleukin 1 beta	Homo sapiens	336-354
30270727-11	2018	Moreover, the plantar s.c. injection of TAK-242 or PDTC inhibited the increased expressions of p-p65, tumor necrosis factor-alpha, and interleukin-1 beta not only in local wounded plantar tissue but also dramatically in ipsilateral lumbar 4-5 DRGs.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	40-47	interleukin 1 beta	Homo sapiens	135-153
29577981-0	2018	Perfluorooctane sulfonate mediates secretion of IL-1beta through PI3K/AKT NF-kB pathway in astrocytes.	perfluorooctane sulfonic acid	0-25	interleukin 1 beta	Homo sapiens	48-56
29577981-6	2018	ELISA and RT-PCR analysis showed that PFOS promoted the expression and secretion of Interleukin-1 beta (IL-1beta) in dose- and time-dependent manners.	perfluorooctane sulfonic acid	38-42	interleukin 1 beta	Homo sapiens	84-102
29577981-6	2018	ELISA and RT-PCR analysis showed that PFOS promoted the expression and secretion of Interleukin-1 beta (IL-1beta) in dose- and time-dependent manners.	perfluorooctane sulfonic acid	38-42	interleukin 1 beta	Homo sapiens	104-112
29577981-9	2018	In addition, pretreatment with AKT inhibitor LY294002 could obviously attenuate PFOS-induced NF-kappaB activation and IL-1beta secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	interleukin 1 beta	Homo sapiens	118-126
29577981-9	2018	In addition, pretreatment with AKT inhibitor LY294002 could obviously attenuate PFOS-induced NF-kappaB activation and IL-1beta secretion.	perfluorooctane sulfonic acid	80-84	interleukin 1 beta	Homo sapiens	118-126
29413364-8	2018	Compared to placebo, ARA supplementation reduced circulating platelet and monocyte number, and decreased the mRNA expression of the immune cell surface markers; neutrophil elastase/CD66b and interleukin 1-beta, in peripheral blood mononuclear cells.	Arachidonic Acid	21-24	interleukin 1 beta	Homo sapiens	191-209
29370572-7	2018	CONCLUSIONS: While the primary efficacy endpoint was not met with gevokizumab, the control of IL-1beta pathway in patients with BDU may still be a relevant target.	Bromodeoxyuridine	128-131	interleukin 1 beta	Homo sapiens	94-102
29425646-9	2018	Thirteen saponins out of the nineteen tested increased IL-1beta concentrations considerably, while six compounds changed IL-2 or IFN-gamma levels slightly.	Saponins	9-17	interleukin 1 beta	Homo sapiens	55-63
29425646-11	2018	CONCLUSION: In this study, almost all saponins with oleanolic acid as aglycones exhibited significant hemolysis, monodesmosidic saponins with hederagenin as aglycone were the most active compounds against lung cancer cells with greater activity than standard commercial chemotherapy drug doxorubicin and some of the hederagenin type saponins induced remarkable IL-1beta secretion.	Saponins	38-46	interleukin 1 beta	Homo sapiens	361-369
29055264-7	2018	Venlafaxine treatment caused greater decreases in the levels of interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), interleukin 4 (IL-4), IL-5, IL-1beta, and IL-8 than did paroxetine.	Venlafaxine Hydrochloride	0-11	interleukin 1 beta	Homo sapiens	163-171
29055264-11	2018	After venlafaxine treatment in both the remitter and non-remitter groups, IL-1beta levels decreased to values seen in the healthy controls.	Venlafaxine Hydrochloride	6-17	interleukin 1 beta	Homo sapiens	74-82
30110695-7	2018	Significant increases in IL-1alpha, IL-1RA, and IL-1beta were observed after cream application at sites treated with polymer A.	polymer a	117-126	interleukin 1 beta	Homo sapiens	48-56
29042315-5	2018	Our results also demonstrated that IL-1beta produced a significant decrease in glutamate release from dorsal hippocampus synaptosomes after reactivation of the fear memory.	Glutamic Acid	79-88	interleukin 1 beta	Homo sapiens	35-43
29042315-8	2018	We found that IL-1beta reduced phosphorylation of this subunit at Serine 831 and Serine 845 60 min after contextual fear memory reactivation.	Serine	66-72	interleukin 1 beta	Homo sapiens	14-22
29042315-8	2018	We found that IL-1beta reduced phosphorylation of this subunit at Serine 831 and Serine 845 60 min after contextual fear memory reactivation.	Serine	81-87	interleukin 1 beta	Homo sapiens	14-22
29042315-10	2018	alpha-MSH prevented the effect of IL-1beta on GluA1 phosphorylation in Serine 845, but not in Serine 831.	Serine	71-77	interleukin 1 beta	Homo sapiens	34-42
29924262-5	2018	RESULTS: Levels of IL-1beta and IL-6 were found to be increased in patients with DENV vs. the healthy controls.	denv	81-85	interleukin 1 beta	Homo sapiens	19-27
29038278-6	2018	Fidaxomicin and OP-1118 dose-dependently inhibited toxin A- and B-induced TNF-alpha and interleukin-1beta (IL-1beta) mRNA expression and histological damage in human colonic explants.	Fidaxomicin	0-11	interleukin 1 beta	Homo sapiens	88-105
29038278-6	2018	Fidaxomicin and OP-1118 dose-dependently inhibited toxin A- and B-induced TNF-alpha and interleukin-1beta (IL-1beta) mRNA expression and histological damage in human colonic explants.	Fidaxomicin	0-11	interleukin 1 beta	Homo sapiens	107-115
29038278-6	2018	Fidaxomicin and OP-1118 dose-dependently inhibited toxin A- and B-induced TNF-alpha and interleukin-1beta (IL-1beta) mRNA expression and histological damage in human colonic explants.	OP-1118	16-23	interleukin 1 beta	Homo sapiens	88-105
29038278-6	2018	Fidaxomicin and OP-1118 dose-dependently inhibited toxin A- and B-induced TNF-alpha and interleukin-1beta (IL-1beta) mRNA expression and histological damage in human colonic explants.	OP-1118	16-23	interleukin 1 beta	Homo sapiens	107-115
29263464-0	2017	[Effect of high glucose-based peritoneal dialysis fluids on NLRP3-IL-1beta in human peritoneal mesothelial cells].	Glucose	16-23	interleukin 1 beta	Homo sapiens	66-74
29269727-4	2017	We demonstrate that differently from LPS-mediated dimerization of the TLR4-MD2 complex, palmitate binds a monomeric TLR4-MD2 complex that triggers endocytosis, ROS generation and increases pro-interleukin-1beta expression in macrophages.	Palmitates	88-97	interleukin 1 beta	Homo sapiens	189-210
29263464-6	2017	Small interfering RNA (siRNA) targeting NLRP3 was used to downregulate the expression of NLRP3 and Western blot was used to evaluate the expression of IL-1beta in human peritoneal mesothelial cells exposed to 4.25% dextrose.	Glucose	215-223	interleukin 1 beta	Homo sapiens	151-159
29263464-1	2017	OBJECTIVE: To explore the effect of high glucose-based peritoneal dialysis fluids on NLRP3-IL-1beta in human peritoneal mesothelial cells.	Glucose	41-48	interleukin 1 beta	Homo sapiens	91-99
29263464-8	2017	RESULTS: The IL-1beta relative expressions were 0, 0.175+-0.082, 0.418+-0.163, 2.357+-0.288, 2.642+-0.358, 3.271+-0.462, and 0.123+-0.091, indicating that the cells exposed to high glucose-based peritoneal dialysis fluids and cells treated with mitochondria respiratory chain key enzyme complex I, and complex III inhibitors increased the IL-1beta expression.	Glucose	181-188	interleukin 1 beta	Homo sapiens	13-21
29258239-1	2017	Saturated fatty acids were proposed to activate the NLRP3 inflammasome, a molecular platform that mediates the processing of interleukin (IL)-1beta and IL-18.	Fatty Acids	0-21	interleukin 1 beta	Homo sapiens	125-147
29263464-12	2017	We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator.	Uric Acid	110-115	interleukin 1 beta	Homo sapiens	90-98
29263464-12	2017	We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator.	Uric Acid	115-131	interleukin 1 beta	Homo sapiens	90-98
29263464-12	2017	We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator.	Nigericin	136-145	interleukin 1 beta	Homo sapiens	90-98
29263464-14	2017	CONCLUSION: Long-term application of high glucose-based peritoneal dialysis fluids can trigger the consistent activation of NLRP3-IL-1beta in peritoneal mesothelial cells.	Glucose	42-49	interleukin 1 beta	Homo sapiens	130-138
29030430-6	2017	Several surface-exposed Lys residues are present in IL-1beta, but not in IL1RN.	Lysine	24-27	interleukin 1 beta	Homo sapiens	52-60
29267498-5	2017	As a result, ginsenoside Rg1 protected HK-2 cells from LPS-induced injury, as cell viability was increased, cell apoptosis was decreased, and the release of MCP-1, IL-1beta, IL-6, and TNF-alpha was reduced.	Ginsenosides	13-24	interleukin 1 beta	Homo sapiens	164-172
29061850-7	2017	Furthermore, in both mouse and human macrophages, TcpB attenuated LPS-induced non-canonical inflammasome activation and suppressed pyroptosis and secretion of IL-1alpha and IL-1beta induced by intracellular LPS delivery.	TCPB	50-54	interleukin 1 beta	Homo sapiens	173-181
29061850-9	2017	Brucella-infected macrophages exhibited minimal pyroptosis but secreted IL-1beta, which was suppressed by TcpB.	TCPB	106-110	interleukin 1 beta	Homo sapiens	72-80
29030430-0	2017	Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.	Disulfides	40-49	interleukin 1 beta	Homo sapiens	61-78
29030430-8	2017	Substitution of the Lys residues to Glu markedly reduced integrin binding of E128K IL-1beta, suggesting that the Lys residues mediate integrin binding.	Lysine	20-23	interleukin 1 beta	Homo sapiens	83-91
29030430-0	2017	Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.	Disulfides	40-49	interleukin 1 beta	Homo sapiens	80-88
29030430-8	2017	Substitution of the Lys residues to Glu markedly reduced integrin binding of E128K IL-1beta, suggesting that the Lys residues mediate integrin binding.	Glutamic Acid	36-39	interleukin 1 beta	Homo sapiens	83-91
29030430-0	2017	Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.	Disulfides	40-49	interleukin 1 beta	Homo sapiens	130-138
29030430-8	2017	Substitution of the Lys residues to Glu markedly reduced integrin binding of E128K IL-1beta, suggesting that the Lys residues mediate integrin binding.	Lysine	113-116	interleukin 1 beta	Homo sapiens	83-91
29030430-10	2017	We studied whether the disulfide linkage plays a role in agonistic action of IL-1beta.	Disulfides	23-32	interleukin 1 beta	Homo sapiens	77-85
29216926-0	2017	Pro-inflammatory adjuvant properties of pigment-grade titanium dioxide particles are augmented by a genotype that potentiates interleukin 1beta processing.	titanium dioxide	54-70	interleukin 1 beta	Homo sapiens	126-143
29292760-8	2017	Also, the expression of three cytokines for the pathogenesis of OA which include IL-1beta, MMP14 and GRP78 was decreased by the various concentrations of icariin.	icariin	154-161	interleukin 1 beta	Homo sapiens	81-89
29216926-2	2017	TiO2 can act as a modest adjuvant in the secretion of the pro-inflammatory cytokine interleukin 1beta (IL-1beta) when triggered by common intestinal bacterial fragments, such as lipopolysaccharide (LPS) and/or peptidoglycan.	titanium dioxide	0-4	interleukin 1 beta	Homo sapiens	84-101
29216926-2	2017	TiO2 can act as a modest adjuvant in the secretion of the pro-inflammatory cytokine interleukin 1beta (IL-1beta) when triggered by common intestinal bacterial fragments, such as lipopolysaccharide (LPS) and/or peptidoglycan.	titanium dioxide	0-4	interleukin 1 beta	Homo sapiens	103-111
29216926-8	2017	In all cases, however, IL-1beta secretion was augmented by chasing with TiO2 in a dose-dependent fashion (5-100 mug/mL).	titanium dioxide	72-76	interleukin 1 beta	Homo sapiens	23-31
29216926-12	2017	CONCLUSION: Here, the doses of TiO2 that augmented bacterial fragment-induced IL-1beta secretion were relatively high.	titanium dioxide	31-35	interleukin 1 beta	Homo sapiens	78-86
29207957-15	2017	It is worth noting that at high percentiles, compared with normal delivery, the expression of IL-1beta, IFN-gamma, IL-8 and HO-1 have significantly altered in women with CDMR.	cdmr	170-174	interleukin 1 beta	Homo sapiens	94-102
29207957-12	2017	At high percentiles of IL-1beta, IFN-gamma and IL-8, women with CDMR had higher expression levels compared to women with VD.	cdmr	64-68	interleukin 1 beta	Homo sapiens	23-31
29065971-2	2017	KHG26792 attenuated the Abeta-induced production of inflammatory mediators such as IL-6, IL-1beta, TNF-alpha, and nitric oxide.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-8	interleukin 1 beta	Homo sapiens	89-97
29207957-13	2017	Women with CDMI had higher levels at median percentiles of IL-1beta, IFN-gamma and IL-8.	2-(2-methyl-4-chlorophenylamino)-2-imidazoline	11-15	interleukin 1 beta	Homo sapiens	59-67
29354290-7	2017	In addition, IL-1beta activated all three well-known UPR pathways: protein kinase RNA-like ER kinase (PERK); activating transcription factor 6 (ATF-6); and inositol-requiring enzyme 1alpha (IRE1alpha).	Inositol	156-164	interleukin 1 beta	Homo sapiens	13-21
29354290-9	2017	IL-1beta and abacavir enhanced intracellular calcium signaling in astrocytes in the absence of extracellular calcium, illustrating ER-associated calcium release.	Calcium	45-52	interleukin 1 beta	Homo sapiens	0-8
29354290-11	2017	Importantly, IL-1beta- and abacavir-induced UPR and mPTP opening were inhibited by the intracellular calcium chelation, indicating the critical role of calcium signaling in HAND-relevant ER stress in astrocytes.	Calcium	101-108	interleukin 1 beta	Homo sapiens	13-21
29354290-11	2017	Importantly, IL-1beta- and abacavir-induced UPR and mPTP opening were inhibited by the intracellular calcium chelation, indicating the critical role of calcium signaling in HAND-relevant ER stress in astrocytes.	Calcium	152-159	interleukin 1 beta	Homo sapiens	13-21
29354290-12	2017	In summary, our study highlights that ARV drugs and IL-1beta induced UPR, AEG-1 expression, intracellular calcium, and mitochondrial depolarization in astrocytes.	Calcium	106-113	interleukin 1 beta	Homo sapiens	52-60
29235551-13	2017	This capacity was significantly stimulated by pretreating the pHCBs with IL-1beta prior to their co-culture with human blood monocytes.	phcbs	62-67	interleukin 1 beta	Homo sapiens	73-81
29230430-7	2018	IL-1beta, IL-6 and TNF-alpha was only significantly increased in cultures exposed to 500 muM TEGDMA.	triethylene glycol dimethacrylate	93-99	interleukin 1 beta	Homo sapiens	0-8
29230430-10	2018	Conclusions: TEGDMA affects production of proinflammatory cytokines IL-1beta, IL-6, IL-8, IL-18 and TNF-alpha.	triethylene glycol dimethacrylate	13-19	interleukin 1 beta	Homo sapiens	68-76
29208967-4	2017	A selective inhibitor, T-5224, significantly suppressed the interleukin-1beta-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription in human nucleus pulposus cells and in a mouse explant culture model of IVD degeneration.	3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid	23-29	interleukin 1 beta	Homo sapiens	60-77
28987943-8	2017	flowers (BME) standardized to the concentration of Butein on human OA chondrocytes stimulated with IL-1beta.	butein	51-57	interleukin 1 beta	Homo sapiens	99-107
29058460-2	2017	In the present study, we demonstrated that ginsenoside Rg1 induced secretion of cytokines, including interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha), and IL-1beta, and chemokines such as IL-8 and IP-10 in a dose-dependent manner by human peripheral blood mononuclear cell (PBMC)-derived dendritic cells.	Ginsenosides	43-54	interleukin 1 beta	Homo sapiens	166-174
27086951-0	2017	IL-1beta limits the extent of human 6-sulfo LacNAc dendritic cell (slanDC)-mediated NK cell activation and regulates CD95-induced apoptosis.	6-sulfo-LacNac	36-50	interleukin 1 beta	Homo sapiens	0-8
27086951-7	2017	Moreover, IL-1beta also induced increased cyclooxygenase-2 expression in slanDCs, which in turn enabled the cells to secrete prostaglandin (PG)-E2.	Dinoprostone	125-146	interleukin 1 beta	Homo sapiens	10-18
28943409-10	2017	SMAD2 linker threonine and serine modifications were observed within 1h following TGFbeta, IL1beta or TGFbeta and IL1beta stimulation.	Threonine	13-22	interleukin 1 beta	Homo sapiens	91-98
28943409-10	2017	SMAD2 linker threonine and serine modifications were observed within 1h following TGFbeta, IL1beta or TGFbeta and IL1beta stimulation.	Threonine	13-22	interleukin 1 beta	Homo sapiens	114-121
28943409-10	2017	SMAD2 linker threonine and serine modifications were observed within 1h following TGFbeta, IL1beta or TGFbeta and IL1beta stimulation.	Serine	27-33	interleukin 1 beta	Homo sapiens	91-98
28943409-10	2017	SMAD2 linker threonine and serine modifications were observed within 1h following TGFbeta, IL1beta or TGFbeta and IL1beta stimulation.	Serine	27-33	interleukin 1 beta	Homo sapiens	114-121
28958159-6	2017	miR-124-3p overexpression attenuated MPP+-induced neuronal injury, displayed as increased cell viability and superoxide dismutase activities, as well as reduced cell apoptosis, Caspase-3 activity, lactate dehydrogenase activity, inflammatory factors TNF-alpha, and IL-1beta levels and reactive oxygen species generation.	mangion-purified polysaccharide (Candida albicans)	37-41	interleukin 1 beta	Homo sapiens	265-273
30416561-3	2017	After several failed attempts, the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) has provided convincing evidence of interleukin-1 beta as a target whose neutralisation by a selective antibody reduces major cardiovascular events without affecting LDL-cholesterol.	Cholesterol	270-281	interleukin 1 beta	Homo sapiens	136-154
29250144-5	2017	It was determined that difference concentrations of formononetin (0.1, 1 and 10 microM) suppressed histamine release and secretion of TNF-alpha, IL-1beta and IL-6.	formononetin	52-64	interleukin 1 beta	Homo sapiens	145-153
28856805-3	2017	Here, we investigated downstream effects of pro-inflammatory IL-1beta to induce cyclooxygenase-2 (COX2) and prostaglandin E2 (PGE2) production in white matter.	Dinoprostone	126-130	interleukin 1 beta	Homo sapiens	61-69
29285149-6	2017	It was observed that the PGSD injection inhibited inflammatory cytokines interleukin-1beta and tumor necrosis factor alpha for patients with VAVR compared with the placebo.	pegaptanib	25-29	interleukin 1 beta	Homo sapiens	73-122
29285125-6	2017	The results revealed the pretreatment with DHMDT significantly inhibited the LPS-induced production of NO, PGE2, TNF-alpha, and IL-1beta, and expression of iNOS, COX-2 TNF-alpha, and IL-1beta, without any significant cytotoxicity.	dhmdt	43-48	interleukin 1 beta	Homo sapiens	128-136
29285125-6	2017	The results revealed the pretreatment with DHMDT significantly inhibited the LPS-induced production of NO, PGE2, TNF-alpha, and IL-1beta, and expression of iNOS, COX-2 TNF-alpha, and IL-1beta, without any significant cytotoxicity.	dhmdt	43-48	interleukin 1 beta	Homo sapiens	183-191
28856805-3	2017	Here, we investigated downstream effects of pro-inflammatory IL-1beta to induce cyclooxygenase-2 (COX2) and prostaglandin E2 (PGE2) production in white matter.	Dinoprostone	108-124	interleukin 1 beta	Homo sapiens	61-69
28756519-0	2017	Anti-Inflammatory Effects of Licochalcone A on IL-1beta-Stimulated Human Osteoarthritis Chondrocytes.	licochalcone A	29-43	interleukin 1 beta	Homo sapiens	47-55
28756519-2	2017	In this study, we evaluated the anti-inflammatory effects of Lico A on IL-1beta-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism.	licochalcone A	61-67	interleukin 1 beta	Homo sapiens	71-79
28756519-3	2017	Results demonstrated that Lico A treatment significantly inhibited PGE2 and NO production induced by IL-1beta.	licochalcone A	26-32	interleukin 1 beta	Homo sapiens	101-109
28801761-0	2017	Milonine, a Morphinandienone Alkaloid, Has Anti-Inflammatory and Analgesic Effects by Inhibiting TNF-alpha and IL-1beta Production.	milonine	0-8	interleukin 1 beta	Homo sapiens	111-119
28756519-3	2017	Results demonstrated that Lico A treatment significantly inhibited PGE2 and NO production induced by IL-1beta.	Dinoprostone	67-71	interleukin 1 beta	Homo sapiens	101-109
28756519-4	2017	IL-1beta-induced iNOS and COX-2 expression were also inhibited by Lico A.	licochalcone A	66-72	interleukin 1 beta	Homo sapiens	0-8
28801761-0	2017	Milonine, a Morphinandienone Alkaloid, Has Anti-Inflammatory and Analgesic Effects by Inhibiting TNF-alpha and IL-1beta Production.	morphinandienone alkaloid	12-37	interleukin 1 beta	Homo sapiens	111-119
28756519-5	2017	Lico A inhibited MMP1, MMP3, and MMP13 production in IL-1beta-stimulated chondrocytes.	licochalcone A	0-6	interleukin 1 beta	Homo sapiens	53-61
28801761-5	2017	The alkaloid was able to inhibit the peritonitis induced by carrageenan, decreasing mainly the migration of polymorphonuclear cells, without altering the mononuclear cell number, and reduced the levels of TNF-alpha and IL-1beta in the peritoneum.	Alkaloids	4-12	interleukin 1 beta	Homo sapiens	219-227
28756519-6	2017	Lico A also inhibited IL-1beta-induced phosphorylation of NF-kappaB p65 and IkappaBalpha.	licochalcone A	0-6	interleukin 1 beta	Homo sapiens	22-30
28756519-9	2017	In conclusion, our results suggested that Lico A showed anti-inflammatory effects in IL-1beta-stimulated chondrocytes by activating Nrf2 signaling pathway.	licochalcone A	42-48	interleukin 1 beta	Homo sapiens	85-93
29181774-7	2017	Concomitantly, extracellular adjuvant particles adsorbed the DAMP molecules released by the cells whereas IL-1beta, a previously reported inflammatory mediator induced by ABAs, was not absorbed by the adjuvants.	abas	171-175	interleukin 1 beta	Homo sapiens	106-114
28888905-11	2017	In apoptosis, IL-1beta-induced terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells and poly (ADP-ribose) polymerase (PARP) and caspase-9 cleavage decreased by RAPTOR RNAi.	deoxyuridine triphosphate	69-73	interleukin 1 beta	Homo sapiens	14-22
28643466-10	2017	ANE treatment also attenuated proteoglycan loss in human cartilage explants treated with IL-1beta ex vivo.	anemonin	0-3	interleukin 1 beta	Homo sapiens	89-97
28610818-9	2017	The ibuprofen group showed a significant reduction in IL-1beta levels from time 0" to time 30" (P=0.038).	Ibuprofen	4-13	interleukin 1 beta	Homo sapiens	54-62
28940479-6	2017	Here, we investigated potential mechanistic links between ceramide as a modulator of NLRP3 inflammasome assembly and the resulting secretion of IL-1beta using small bioactive enzyme stimulators and inhibitors of ceramide signaling in wild-type and apoptosis-associated speck-like protein containing a CARD knockout (ASC-/- ) primary microglia.	Ceramides	58-66	interleukin 1 beta	Homo sapiens	144-152
28940479-8	2017	Treatment with sodium palmitate (PA) induced de novo ceramide synthesis via modulation of its synthesizing protein serine palmitoyl transferase resulting in increased IL-1beta secretion in microglia.	Palmitic Acid	15-31	interleukin 1 beta	Homo sapiens	167-175
28940479-8	2017	Treatment with sodium palmitate (PA) induced de novo ceramide synthesis via modulation of its synthesizing protein serine palmitoyl transferase resulting in increased IL-1beta secretion in microglia.	Palmitates	33-35	interleukin 1 beta	Homo sapiens	167-175
28940479-8	2017	Treatment with sodium palmitate (PA) induced de novo ceramide synthesis via modulation of its synthesizing protein serine palmitoyl transferase resulting in increased IL-1beta secretion in microglia.	Ceramides	53-61	interleukin 1 beta	Homo sapiens	167-175
28940479-9	2017	Exposure of microglia to the serine palmitoyl transferase-inhibitor l-cycloserine significantly prevented PA-induced IL-1beta secretion.	L-Cycloserine	68-81	interleukin 1 beta	Homo sapiens	117-125
28940479-9	2017	Exposure of microglia to the serine palmitoyl transferase-inhibitor l-cycloserine significantly prevented PA-induced IL-1beta secretion.	Palmitates	106-108	interleukin 1 beta	Homo sapiens	117-125
28940479-10	2017	Application of the ceramide analogue C2 and the sphingosine-1-phosphate-receptor agonist Fingolimod (FTY720) up-regulated levels of IL-1beta and cleaved caspase-1 in wild-type microglia, whereas ASC-/- microglia were unaffected.	Ceramides	19-27	interleukin 1 beta	Homo sapiens	132-140
28940479-10	2017	Application of the ceramide analogue C2 and the sphingosine-1-phosphate-receptor agonist Fingolimod (FTY720) up-regulated levels of IL-1beta and cleaved caspase-1 in wild-type microglia, whereas ASC-/- microglia were unaffected.	Fingolimod Hydrochloride	89-99	interleukin 1 beta	Homo sapiens	132-140
28940479-12	2017	Taken together, our findings reveal a critical role for ceramide as a positive modulator of NLRP3 inflammasome assembly and the resulting release of IL-1beta.	Ceramides	56-64	interleukin 1 beta	Homo sapiens	149-157
28964890-9	2017	ABT-981 significantly reduced absolute neutrophil count and serum concentrations of IL-1alpha/IL-1beta, high-sensitivity C-reactive protein, and matrix metalloproteinase (MMP)-derived type 1 collagen.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	interleukin 1 beta	Homo sapiens	94-102
28945145-10	2017	Moreover, SRP+diode laser determined a reduction in mean GCF level of interleukin (IL)-1beta and IL-1beta/IL-10 ratio at 15 and 30 days compared to SRP alone (p &lt; 0.05).	L-seryl-AMP	10-13	interleukin 1 beta	Homo sapiens	97-105
28988892-7	2017	Finally, IL-1beta-induced nuclear factor kappaB (NF-kappaB) transcriptional activity was significantly attenuated by transfection with siMyD88, siTRAF6 and siIRAK4; there was no effect of siTAK1 transfection on NF-kappaB transcriptional activity.	simyd88	135-142	interleukin 1 beta	Homo sapiens	9-17
28988892-7	2017	Finally, IL-1beta-induced nuclear factor kappaB (NF-kappaB) transcriptional activity was significantly attenuated by transfection with siMyD88, siTRAF6 and siIRAK4; there was no effect of siTAK1 transfection on NF-kappaB transcriptional activity.	sitraf6	144-151	interleukin 1 beta	Homo sapiens	9-17
29312598-6	2017	In the present study, we demonstrated that IL-22 promoting IL-1beta secretion from keratinocytes via the Reactive oxygen species (ROS)-NOD-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1 pathway.	Reactive Oxygen Species	105-128	interleukin 1 beta	Homo sapiens	59-67
29312598-6	2017	In the present study, we demonstrated that IL-22 promoting IL-1beta secretion from keratinocytes via the Reactive oxygen species (ROS)-NOD-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1 pathway.	Reactive Oxygen Species	130-133	interleukin 1 beta	Homo sapiens	59-67
29170665-8	2017	Our results show that the beta-glucan fungal cell wall carbohydrate stimulated B-lymphocytes to secrete IL-1beta in a process partially mediated by Dectin-1 activation via SYK and the transcription factors NF-kappaB and AP-1.	Carbohydrates	55-67	interleukin 1 beta	Homo sapiens	104-112
28990778-8	2017	Compared with the BaP group, the autophagy inhibitor 3-MA significantly (p &lt; 0.01) inhibited the release of LDH by 70.53% +- 0.46 and NO by 50.36% +- 0.80, the increase of electrical conductivity by 12.08% +- 0.55, and the expressions of pyroptotic marker proteins (Caspase-1, Cox-2, IL-1beta, IL-18).	3-methyladenine	53-57	interleukin 1 beta	Homo sapiens	287-295
29165387-0	2017	Nitric Oxide Mediates Crosstalk between Interleukin 1beta and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	40-57
29033131-5	2017	Increasing macrophage cholesterol content is sufficient to trigger IL-1beta release in a crystal-independent but AIM2-dependent manner.	Cholesterol	22-33	interleukin 1 beta	Homo sapiens	67-75
28933476-0	2017	Piceatannol inhibits the IL-1beta-induced inflammatory response in human osteoarthritic chondrocytes and ameliorates osteoarthritis in mice by activating Nrf2.	3,3',4,5'-tetrahydroxystilbene	0-11	interleukin 1 beta	Homo sapiens	25-33
29170665-8	2017	Our results show that the beta-glucan fungal cell wall carbohydrate stimulated B-lymphocytes to secrete IL-1beta in a process partially mediated by Dectin-1 activation via SYK and the transcription factors NF-kappaB and AP-1.	beta-Glucans	26-37	interleukin 1 beta	Homo sapiens	104-112
29170665-9	2017	This IL-1beta secretion was regulated by the NLRP3 inflammasome and was dependent on potassium efflux and Caspase-1.	Potassium	85-94	interleukin 1 beta	Homo sapiens	5-13
29115971-7	2017	However, local anaesthetics alone or in combination with morphine and/or MgSO4 reduced cell viability and increased the gene expression of IL-1beta, IL-6 or TNF-alpha.	Morphine	57-65	interleukin 1 beta	Homo sapiens	139-147
29115971-7	2017	However, local anaesthetics alone or in combination with morphine and/or MgSO4 reduced cell viability and increased the gene expression of IL-1beta, IL-6 or TNF-alpha.	Magnesium Sulfate	73-78	interleukin 1 beta	Homo sapiens	139-147
29113115-7	2017	Combination of FRA and low-dose MTX was more effective than MTX alone when comparing body weight, hind paw volume, arthritic score, plasmatic levels of IL-1beta, activity of gamma-glutamyl transferase, and relative mRNA expression of IL-1beta in the spleen.	Methotrexate	32-35	interleukin 1 beta	Homo sapiens	234-242
29096724-9	2017	RESULTS: Treating HepG2 cells with PA-LPS caused NLRP3 inflammation activation, including overexpression of NLRP3 and caspase-1, and overproduction of IL-1beta and IL-18 as well as TNF-alpha from HepG2 cells.	pa-lps	35-41	interleukin 1 beta	Homo sapiens	151-159
29226077-5	2017	We also revealed that antagonists of tumor necrosis factor, IL-6 and IL-1beta down-regulated ROS production of RA FLS induced by leptin, which subsequently attenuated RA FLS migration and HUVEC tube formation.	Reactive Oxygen Species	93-96	interleukin 1 beta	Homo sapiens	69-77
29750184-6	2018	Results: In samples from 14 patients we confirmed a strongly compartmentalized immune response at the disease site and found that prednisolone significantly reduced IL-6 concentrations in plasma by 8 hours of treatment, IL-1beta concentrations in saliva, as well as IL-8 concentrations in both pericardial fluid and saliva by 24 hours.	Prednisolone	130-142	interleukin 1 beta	Homo sapiens	220-228
28890259-9	2017	We found that silk-CS scaffold maintained better chondrocyte phenotype than silk scaffold; moreover, the silk-CS scaffolds reduced chondrocyte inflammatory response that was induced by interleukin (IL)-1beta, which is in consistent with the well-documented anti-inflammatory activities of CS.	Chondroitin Sulfates	19-21	interleukin 1 beta	Homo sapiens	185-207
28890259-9	2017	We found that silk-CS scaffold maintained better chondrocyte phenotype than silk scaffold; moreover, the silk-CS scaffolds reduced chondrocyte inflammatory response that was induced by interleukin (IL)-1beta, which is in consistent with the well-documented anti-inflammatory activities of CS.	Chondroitin Sulfates	110-112	interleukin 1 beta	Homo sapiens	185-207
28890259-9	2017	We found that silk-CS scaffold maintained better chondrocyte phenotype than silk scaffold; moreover, the silk-CS scaffolds reduced chondrocyte inflammatory response that was induced by interleukin (IL)-1beta, which is in consistent with the well-documented anti-inflammatory activities of CS.	Chondroitin Sulfates	110-112	interleukin 1 beta	Homo sapiens	185-207
29096724-12	2017	Furthermore, knockdown of NLRP3 or IL-1beta partially improved PA and LPS-induced insulin signaling impairments in the presence of UC-MSCs.	Palmitic Acid	63-65	interleukin 1 beta	Homo sapiens	35-43
29097764-7	2017	CP value of SN in PD group was significantly and negatively correlated with interleukin-1beta level in CSF, so interleukin-1beta might be a neuroinflammatory factor produced by excessive iron in SN.	Iron	187-191	interleukin 1 beta	Homo sapiens	111-128
29263046-0	2017	Berberine Attenuates NLRP3 Inflammasome Activation in Macrophages to Reduce the Secretion of Interleukin-1beta.	Berberine	0-9	interleukin 1 beta	Homo sapiens	93-110
29263046-7	2017	RESULTS: In this study we observed that berberine suppressed IL-1beta secretion that was induced by the activation of the NLRP3 inflammasome in macrophages.	Berberine	40-49	interleukin 1 beta	Homo sapiens	61-69
29263046-9	2017	Moreover, Berberine inhibited the expression of pro-IL-1beta through inhibition of the nuclear factor kappab (NF-kappaB) pathway, which prevented the priming IL-1beta secretion.	Berberine	10-19	interleukin 1 beta	Homo sapiens	48-60
29263046-9	2017	Moreover, Berberine inhibited the expression of pro-IL-1beta through inhibition of the nuclear factor kappab (NF-kappaB) pathway, which prevented the priming IL-1beta secretion.	Berberine	10-19	interleukin 1 beta	Homo sapiens	52-60
29263046-10	2017	CONCLUSION: Our results suggest that berberine alleviates NLRP3 inflammation activation by reducing IL-1beta secretion from macrophages, which could be an important therapeutic target in atherosclerosis.	Berberine	37-46	interleukin 1 beta	Homo sapiens	100-108
28866026-10	2017	Furthermore, bezafibrate treatment significantly suppressed interleukin (IL)-1beta-induced vascular endothelial growth factor (VEGF) production in ARPE-19 cells.	Bezafibrate	13-24	interleukin 1 beta	Homo sapiens	60-82
28941802-10	2017	In addition, the IL-1beta receptor antagonist IL1RN or the JNK inhibitor SP600125, both restored the down-regulation of RPS27 induced by CFTRinh-172, implying a role of autocrine IL-1beta and JNK signaling downstream of Cl- in RPS27 modulation.	3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone	137-148	interleukin 1 beta	Homo sapiens	17-25
28512729-0	2017	Protective effects of Nebivolol against interleukin-1beta (IL-1beta)-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13).	Nebivolol	22-31	interleukin 1 beta	Homo sapiens	40-57
28512729-0	2017	Protective effects of Nebivolol against interleukin-1beta (IL-1beta)-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13).	Nebivolol	22-31	interleukin 1 beta	Homo sapiens	59-67
28512729-6	2017	Our results indicate that Nebivolol alleviated the increase in gene expression, protein expression, and activity of MMP-13 induced by IL-1beta.	Nebivolol	26-35	interleukin 1 beta	Homo sapiens	134-142
28512729-7	2017	Importantly, IL-1beta strikingly reduced the levels of type II collagen in cell culture supernatants, which was reversed by treatment with Nebivolol in a dose-dependent manner.	Nebivolol	139-148	interleukin 1 beta	Homo sapiens	13-21
28942223-12	2017	We found that baicalin significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, MMP-3, MMP-13 and ADAMTS-5 and degradation of aggrecan and collagen-II.	baicalin	14-22	interleukin 1 beta	Homo sapiens	51-59
28942223-12	2017	We found that baicalin significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, MMP-3, MMP-13 and ADAMTS-5 and degradation of aggrecan and collagen-II.	Dinoprostone	89-93	interleukin 1 beta	Homo sapiens	51-59
28964868-7	2017	Moreover, rosiglitazone significantly normalized the inflammatory responses (TNF-alpha and IL-1beta), NF-kappaB (p65), and inflammatory genes (iNOS and COX-2) in the hNSCs treated with AGEs.	Rosiglitazone	10-23	interleukin 1 beta	Homo sapiens	91-99
28941802-10	2017	In addition, the IL-1beta receptor antagonist IL1RN or the JNK inhibitor SP600125, both restored the down-regulation of RPS27 induced by CFTRinh-172, implying a role of autocrine IL-1beta and JNK signaling downstream of Cl- in RPS27 modulation.	3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone	137-148	interleukin 1 beta	Homo sapiens	179-187
28850024-9	2017	CONCLUSIONS: Cilostazol pretreatment can reduce the excessive expression of inflammatory cytokines and chemokines and hnRNP A2/B1 by the BD-related stimulants, including TNF-alpha, IL-1beta, and LPS, in HDMECs.	Cilostazol	13-23	interleukin 1 beta	Homo sapiens	181-189
28918367-4	2017	Since 25-hydroxycholesterol (25-HC), a metabolite of cholesterol, can suppress IL-1beta production, thus reducing inflammation, we evaluated the effect of 25-HC in an in vitro model of mevalonate pathway alteration, obtained using Lovastatin.	25-hydroxycholesterol	6-27	interleukin 1 beta	Homo sapiens	79-87
28918367-4	2017	Since 25-hydroxycholesterol (25-HC), a metabolite of cholesterol, can suppress IL-1beta production, thus reducing inflammation, we evaluated the effect of 25-HC in an in vitro model of mevalonate pathway alteration, obtained using Lovastatin.	25-hydroxycholesterol	29-34	interleukin 1 beta	Homo sapiens	79-87
28918367-4	2017	Since 25-hydroxycholesterol (25-HC), a metabolite of cholesterol, can suppress IL-1beta production, thus reducing inflammation, we evaluated the effect of 25-HC in an in vitro model of mevalonate pathway alteration, obtained using Lovastatin.	Cholesterol	16-27	interleukin 1 beta	Homo sapiens	79-87
28736247-0	2017	Interleukin-1beta affects the phospholipid biosynthesis of fibroblast-like synoviocytes from human osteoarthritic knee joints.	Phospholipids	30-42	interleukin 1 beta	Homo sapiens	0-17
29078913-2	2017	We previously confirmed the effects of naloxone on inhibiting upregulation of inflammatory cytokine interleukin-1beta (IL-1beta).	Naloxone	39-47	interleukin 1 beta	Homo sapiens	100-117
29078913-2	2017	We previously confirmed the effects of naloxone on inhibiting upregulation of inflammatory cytokine interleukin-1beta (IL-1beta).	Naloxone	39-47	interleukin 1 beta	Homo sapiens	119-127
28901512-7	2017	Treatment with gambogic acid suppressed the activities of interleukin (IL)-1beta and IL-6, promoted the protein expression of phosphorylated (p)-Akt serine/threonine kinase (Akt), p-mammalian target protein of rapamycin (mTOR) and inhibited hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression in RA rats.	gambogic acid	15-28	interleukin 1 beta	Homo sapiens	58-80
28666830-4	2017	The production of TNF-alpha, IL-1beta and IL-6 and their mRNA expression levels markedly decreased while the level and mRNA expression of IL-10 were elevated when the cells were treated with Sophora subprosrate polysaccharide.	Polysaccharides	211-225	interleukin 1 beta	Homo sapiens	29-37
29048735-7	2017	In addition, real-time polymerase chain reaction and enzyme-linked immunosorbent assay results indicated that 6-OHDA elevated the production of proinflammatory cytokines, such as interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha.	Oxidopamine	110-116	interleukin 1 beta	Homo sapiens	179-196
29078913-7	2017	RESULTS: Enzyme-link immunosorbent assay data revealed that the concentration of IL-1beta in THP-1 cells treated with LPS plus ATP was significantly higher than that in THP-1 cells treated with LPS plus ATP plus naloxone (0.1 muM) (P &lt; 0.001).	Adenosine Triphosphate	127-130	interleukin 1 beta	Homo sapiens	81-89
29078913-7	2017	RESULTS: Enzyme-link immunosorbent assay data revealed that the concentration of IL-1beta in THP-1 cells treated with LPS plus ATP was significantly higher than that in THP-1 cells treated with LPS plus ATP plus naloxone (0.1 muM) (P &lt; 0.001).	Adenosine Triphosphate	203-206	interleukin 1 beta	Homo sapiens	81-89
29078913-7	2017	RESULTS: Enzyme-link immunosorbent assay data revealed that the concentration of IL-1beta in THP-1 cells treated with LPS plus ATP was significantly higher than that in THP-1 cells treated with LPS plus ATP plus naloxone (0.1 muM) (P &lt; 0.001).	Naloxone	212-220	interleukin 1 beta	Homo sapiens	81-89
28963928-7	2017	Additionally, cessation of IL-1beta rescued T-2-elicited tilt of matrix homeostasis toward catabolism by elevating the transcription of collagen II and aggrecan, promoting release of sulphated glycosaminoglycans (sGAG) and TIMP1, and suppressing matrix metalloproteinases production including MMP-1, MMP-3 and MMP-13.	Glycosaminoglycans	193-211	interleukin 1 beta	Homo sapiens	27-35
29068698-4	2017	Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid.	Polyphenols	0-11	interleukin 1 beta	Homo sapiens	112-120
28736247-8	2017	IL-1beta increased the biosynthesis of both phosphatidylethanolamine (PE) and PE-based plasmalogens.	phosphatidylethanolamine	44-68	interleukin 1 beta	Homo sapiens	0-8
28736247-8	2017	IL-1beta increased the biosynthesis of both phosphatidylethanolamine (PE) and PE-based plasmalogens.	phosphatidylethanolamine	70-72	interleukin 1 beta	Homo sapiens	0-8
28736247-8	2017	IL-1beta increased the biosynthesis of both phosphatidylethanolamine (PE) and PE-based plasmalogens.	phosphatidylethanolamine	78-80	interleukin 1 beta	Homo sapiens	0-8
28736247-9	2017	We show here that the NF-kappaB, p38 MAPK and JNK signaling pathways are all involved in IL-1beta-induced PL biosynthesis.	Phospholipids	106-108	interleukin 1 beta	Homo sapiens	89-97
29163489-7	2017	Finally, Curc-SPNs were shown to diminish up to 6.5-fold the production of pro-inflammatory cytokines-IL-1beta; IL-6, and TNF-alpha-in macrophages stimulated via amyloid-beta fibers.	curc-spns	9-18	interleukin 1 beta	Homo sapiens	102-110
28767045-8	2017	Further, cytokine analysis revealed that hydrochloric acid treatments induced significantly higher IL-1beta and TNF-alpha release with respect to acetic acid treatments.	Hydrochloric Acid	41-58	interleukin 1 beta	Homo sapiens	99-107
29059216-9	2017	In addition, DEX (1 mg/kg) reduced the cytokine levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and macrophage migration inhibitory factor (MIF).	Dexamethasone	13-16	interleukin 1 beta	Homo sapiens	93-115
29118740-9	2017	Treatment with ASA or CEL did not affect TNF-alpha, IL-6, IL-8, IL-10, and NO production by infected cells, but increased IL-1beta production by them.	Aspirin	15-18	interleukin 1 beta	Homo sapiens	122-130
29118740-9	2017	Treatment with ASA or CEL did not affect TNF-alpha, IL-6, IL-8, IL-10, and NO production by infected cells, but increased IL-1beta production by them.	Celecoxib	22-25	interleukin 1 beta	Homo sapiens	122-130
28952621-8	2017	We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II.	oleuropein	14-16	interleukin 1 beta	Homo sapiens	45-53
28952621-8	2017	We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II.	Dinoprostone	83-87	interleukin 1 beta	Homo sapiens	45-53
28701056-6	2017	IL-1beta stimulation induced an inflammatory response with a significant increase in the secretion of PGE2, IL-6, IL-8 and MMP-1.	Dinoprostone	102-106	interleukin 1 beta	Homo sapiens	0-8
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	dapt	13-17	interleukin 1 beta	Homo sapiens	51-59
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	Lithium Chloride	22-26	interleukin 1 beta	Homo sapiens	51-59
29057315-6	2017	Interestingly, exposure of LPS-primed microglial cells to the mitochondrial complex-I inhibitory pesticides rotenone and tebufenpyrad specifically potentiated the NLRP3 induction, ASC speck formation and pro-IL-1beta processing to IL-1beta in a dose-dependent manner, indicating that mitochondrial impairment heightened the NLRP3 inflammasome-mediated proinflammatory response in microglia.	Rotenone	108-116	interleukin 1 beta	Homo sapiens	204-216
29057315-6	2017	Interestingly, exposure of LPS-primed microglial cells to the mitochondrial complex-I inhibitory pesticides rotenone and tebufenpyrad specifically potentiated the NLRP3 induction, ASC speck formation and pro-IL-1beta processing to IL-1beta in a dose-dependent manner, indicating that mitochondrial impairment heightened the NLRP3 inflammasome-mediated proinflammatory response in microglia.	Rotenone	108-116	interleukin 1 beta	Homo sapiens	208-216
29057315-8	2017	Furthermore, the pesticides enhanced mitochondrial ROS generation in primary microglia, while amelioration of mitochondria-derived ROS by the mitochondria-targeted antioxidant mito-apocynin completely abolished IL-1beta release, indicating mitochondrial ROS drives potentiation of the NLRP3 inflammasome in microglia.	ros	131-134	interleukin 1 beta	Homo sapiens	211-219
29057315-8	2017	Furthermore, the pesticides enhanced mitochondrial ROS generation in primary microglia, while amelioration of mitochondria-derived ROS by the mitochondria-targeted antioxidant mito-apocynin completely abolished IL-1beta release, indicating mitochondrial ROS drives potentiation of the NLRP3 inflammasome in microglia.	ros	131-134	interleukin 1 beta	Homo sapiens	211-219
29152046-5	2017	Cytokine profiles are also reported that show the pure TLR8 agonist [4-amino-2-butyl-1-(2-aminoethyl)-7-methoxycarbonyl-1H-imidazo[4,5-c]quinoline] induces higher levels of IL-1beta, IL-12, and IFNgamma when compared with TLR7 selective or mixed TLR7/8 agonists.	4-amino-2-butyl-1-(2-aminoethyl)-7-methoxycarbonyl-1h-imidazo[4,5-c]quinoline	69-146	interleukin 1 beta	Homo sapiens	173-181
28701056-7	2017	Treatment of IL-1beta stimulated fibroblasts in combination with PHMG-P or CHX at concentrations of 0.000045 or 0.0.00009% resulted in significantly decreased PGE2, IL-6, IL-8 and MMP-1 levels.	polyhexamethyleneguanidine	65-71	interleukin 1 beta	Homo sapiens	13-21
28701056-7	2017	Treatment of IL-1beta stimulated fibroblasts in combination with PHMG-P or CHX at concentrations of 0.000045 or 0.0.00009% resulted in significantly decreased PGE2, IL-6, IL-8 and MMP-1 levels.	Chlorhexidine	75-78	interleukin 1 beta	Homo sapiens	13-21
28701056-7	2017	Treatment of IL-1beta stimulated fibroblasts in combination with PHMG-P or CHX at concentrations of 0.000045 or 0.0.00009% resulted in significantly decreased PGE2, IL-6, IL-8 and MMP-1 levels.	Dinoprostone	159-163	interleukin 1 beta	Homo sapiens	13-21
29078843-2	2017	Our aim is to investigate the correlation between tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) in EBC and in lung tissue, and between these values in EBC with pulmonary function tests in patients with chronic obstructive pulmonary disease (COPD).	NSC638702	126-129	interleukin 1 beta	Homo sapiens	94-111
29078843-2	2017	Our aim is to investigate the correlation between tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) in EBC and in lung tissue, and between these values in EBC with pulmonary function tests in patients with chronic obstructive pulmonary disease (COPD).	NSC638702	126-129	interleukin 1 beta	Homo sapiens	113-121
29078843-12	2017	There was a positive correlation between TNF-alpha and IL-1beta in lung tissues and in EBC.	NSC638702	87-90	interleukin 1 beta	Homo sapiens	55-63
28551814-3	2017	This study investigates the role of macrophage-derived, caspase-1-dependent interleukin-1beta (IL-1beta) in an in vitro model of LVI.	lvi	129-132	interleukin 1 beta	Homo sapiens	76-93
28892713-7	2017	SA also impairs CAC function and increases pro-inflammatory molecule (IL-1beta, IL-6, IL-8, MCP-1 and TNFalpha) gene expression and secretion in CACs starting from 3 h of incubation.	stearic acid	0-2	interleukin 1 beta	Homo sapiens	70-78
28529072-6	2017	Moreover, EPA and DHA also reversed the IL-1beta-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1beta-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO).	Sertraline	155-165	interleukin 1 beta	Homo sapiens	40-48
28529072-6	2017	Moreover, EPA and DHA also reversed the IL-1beta-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1beta-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO).	Sertraline	155-165	interleukin 1 beta	Homo sapiens	179-187
28529072-6	2017	Moreover, EPA and DHA also reversed the IL-1beta-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1beta-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO).	Quinolinic Acid	208-223	interleukin 1 beta	Homo sapiens	40-48
28529072-7	2017	Our results show common effects of monoaminergic antidepressants and omega-3 fatty acids on the reduction of neurogenesis caused by IL-1beta, but acting through both common and different kynurenine pathway-related mechanisms.	Fatty Acids, Omega-3	69-88	interleukin 1 beta	Homo sapiens	132-140
28879435-5	2017	In addition, the gamma-PGA-APA was shown to exert low cytotoxicity and noticeable immunomodulatory activities towards TNF-alpha and IL-1beta gene expression.	gamma-pga-apa	17-30	interleukin 1 beta	Homo sapiens	132-140
28529072-0	2017	Rescue of IL-1beta-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants.	Fatty Acids, Omega-3	62-81	interleukin 1 beta	Homo sapiens	10-18
28529072-6	2017	Moreover, EPA and DHA also reversed the IL-1beta-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1beta-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO).	Eicosapentaenoic Acid	10-13	interleukin 1 beta	Homo sapiens	40-48
28529072-6	2017	Moreover, EPA and DHA also reversed the IL-1beta-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1beta-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO).	Eicosapentaenoic Acid	10-13	interleukin 1 beta	Homo sapiens	179-187
28529072-6	2017	Moreover, EPA and DHA also reversed the IL-1beta-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1beta-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO).	Docosahexaenoic Acids	18-21	interleukin 1 beta	Homo sapiens	40-48
28529072-6	2017	Moreover, EPA and DHA also reversed the IL-1beta-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1beta-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO).	Docosahexaenoic Acids	18-21	interleukin 1 beta	Homo sapiens	179-187
28529072-6	2017	Moreover, EPA and DHA also reversed the IL-1beta-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1beta-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO).	Kynurenine	69-79	interleukin 1 beta	Homo sapiens	40-48
28529072-6	2017	Moreover, EPA and DHA also reversed the IL-1beta-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1beta-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO).	Docosahexaenoic Acids	147-150	interleukin 1 beta	Homo sapiens	40-48
28551814-3	2017	This study investigates the role of macrophage-derived, caspase-1-dependent interleukin-1beta (IL-1beta) in an in vitro model of LVI.	lvi	129-132	interleukin 1 beta	Homo sapiens	95-103
28296211-6	2017	Based on the constructed three-dimensional structure of pro-IL-1beta, rs375479974 with a mutation of Phe to Ser was proposed to reduce the stability of the pro-IL-1beta protein.	Phenylalanine	101-104	interleukin 1 beta	Homo sapiens	56-68
28296211-6	2017	Based on the constructed three-dimensional structure of pro-IL-1beta, rs375479974 with a mutation of Phe to Ser was proposed to reduce the stability of the pro-IL-1beta protein.	Phenylalanine	101-104	interleukin 1 beta	Homo sapiens	156-168
28651331-0	2017	IL-1beta Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells.	Progesterone	30-42	interleukin 1 beta	Homo sapiens	0-8
28296211-6	2017	Based on the constructed three-dimensional structure of pro-IL-1beta, rs375479974 with a mutation of Phe to Ser was proposed to reduce the stability of the pro-IL-1beta protein.	Serine	108-111	interleukin 1 beta	Homo sapiens	56-68
28296211-6	2017	Based on the constructed three-dimensional structure of pro-IL-1beta, rs375479974 with a mutation of Phe to Ser was proposed to reduce the stability of the pro-IL-1beta protein.	Serine	108-111	interleukin 1 beta	Homo sapiens	156-168
28296211-8	2017	When analyzing the interaction between the experimental 3D structure of mature IL-1beta and its neutralizing McAb canakinumab complex, the rs775174784 substitution of Leu with Phe was found to attenuate this interaction by reducing binding energy, while rs375479974 not.	mcab	109-113	interleukin 1 beta	Homo sapiens	79-87
28296211-8	2017	When analyzing the interaction between the experimental 3D structure of mature IL-1beta and its neutralizing McAb canakinumab complex, the rs775174784 substitution of Leu with Phe was found to attenuate this interaction by reducing binding energy, while rs375479974 not.	Leucine	167-170	interleukin 1 beta	Homo sapiens	79-87
28296211-8	2017	When analyzing the interaction between the experimental 3D structure of mature IL-1beta and its neutralizing McAb canakinumab complex, the rs775174784 substitution of Leu with Phe was found to attenuate this interaction by reducing binding energy, while rs375479974 not.	Phenylalanine	176-179	interleukin 1 beta	Homo sapiens	79-87
28651331-4	2017	Moreover, IL-1beta activated the phosphorylation of cyclic adenosine monophosphate response element-binding protein (CREB), and knockdown of CREB attenuated the induction of StAR expression and progesterone synthesis by IL-1beta in granulosa-lutein cells.	Cyclic AMP	52-82	interleukin 1 beta	Homo sapiens	220-228
28651331-4	2017	Moreover, IL-1beta activated the phosphorylation of cyclic adenosine monophosphate response element-binding protein (CREB), and knockdown of CREB attenuated the induction of StAR expression and progesterone synthesis by IL-1beta in granulosa-lutein cells.	Progesterone	194-206	interleukin 1 beta	Homo sapiens	10-18
28651331-5	2017	Furthermore, IL-1beta activated the extracellular signal-regulated kinase (ERK)1/2 and p38 pathways and inhibition of the ERK1/2 and p38 pathways attenuated the IL-1beta-induced phosphorylation of CREB, StAR expression, and progesterone synthesis in granulosa-lutein cells.	Progesterone	224-236	interleukin 1 beta	Homo sapiens	13-21
28651331-1	2017	The proinflammatory cytokine interleukin-1beta (IL-1beta) may be involved in several ovulation-associated events, such as protease synthesis, prostaglandin production, and steroidogenesis in granulosa cells.	Prostaglandins	142-155	interleukin 1 beta	Homo sapiens	29-46
28651331-5	2017	Furthermore, IL-1beta activated the extracellular signal-regulated kinase (ERK)1/2 and p38 pathways and inhibition of the ERK1/2 and p38 pathways attenuated the IL-1beta-induced phosphorylation of CREB, StAR expression, and progesterone synthesis in granulosa-lutein cells.	Progesterone	224-236	interleukin 1 beta	Homo sapiens	161-169
28651331-6	2017	In conclusion, IL-1beta could upregulate StAR expression and stimulate progesterone biosynthesis through increase in CREB phosphorylation via activating the ERK1/2 and p38 pathways in human granulosa-lutein cells.	Progesterone	71-83	interleukin 1 beta	Homo sapiens	15-23
28651331-1	2017	The proinflammatory cytokine interleukin-1beta (IL-1beta) may be involved in several ovulation-associated events, such as protease synthesis, prostaglandin production, and steroidogenesis in granulosa cells.	Prostaglandins	142-155	interleukin 1 beta	Homo sapiens	48-56
28651331-2	2017	However, the exact effect of IL-1beta on progesterone synthesis in granulosa cells and the underlying mechanism remain unclear.	Progesterone	41-53	interleukin 1 beta	Homo sapiens	29-37
28651331-3	2017	By using cultured granulosa-lutein cells collected from women undergoing in vitro fertilization or intracytoplasmic sperm injection, we found that IL-1beta upregulated steroidogenic acute regulatory protein (StAR) expression and progesterone synthesis in granulosa-lutein cells, which was comparable with luteinizing hormone effect and could be abolished by an IL-1 receptor antagonist.	Progesterone	229-241	interleukin 1 beta	Homo sapiens	147-155
28651331-4	2017	Moreover, IL-1beta activated the phosphorylation of cyclic adenosine monophosphate response element-binding protein (CREB), and knockdown of CREB attenuated the induction of StAR expression and progesterone synthesis by IL-1beta in granulosa-lutein cells.	Cyclic AMP	52-82	interleukin 1 beta	Homo sapiens	10-18
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	polyinosinic:	15-28	interleukin 1 beta	Homo sapiens	268-276
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	48-56	interleukin 1 beta	Homo sapiens	268-276
28266737-6	2017	We transfected polyinosinic:polycytidylic acid (poly I:C), a synthetic viral dsRNA analogue, into cultured primary human keratinocytes at the aid of Lipofectamine 2000, and found that transfected poly I:C activated caspase-1 and induced caspase-1-dependent release of IL-1beta and IL-18, which were suppressed on transfection with NLRP3 siRNA.	Poly I-C	196-204	interleukin 1 beta	Homo sapiens	268-276
28536017-8	2017	On horse and human chondrocytes, they reduced the IL-1beta-induced liberation of NO and PGE2, and on RAW 264.7 immortalized macrophage-like cell line, C4S, C6S, Ch and Sk-CS decreased the LPS-induced liberation of TNF-alpha, but did not affect IL-6.	Dinoprostone	88-92	interleukin 1 beta	Homo sapiens	50-58
28707358-6	2017	DHEA-S treatment reduced IL-1beta and -6 release from activated human myeloid cells with minimal effect on lymphocyte viability.	Dehydroepiandrosterone	0-6	interleukin 1 beta	Homo sapiens	25-40
28707358-7	2017	Animals with EAE receiving DHEA-S treatment showed reduced Il1b and Ifng transcript levels in spinal cord compared to vehicle-treated animals with EAE.	Dehydroepiandrosterone	27-33	interleukin 1 beta	Homo sapiens	59-63
28536017-9	2017	In contrast, on bone marrow derived macrophages, C4S, C6S, BT and PT-CS reduced the LPS-induced liberation of TNF-alpha, IL-6, IL-1beta and NO, indicating that the RAW response to CS was different from that of primary macrophages.	benzothiazole	59-61	interleukin 1 beta	Homo sapiens	127-135
28584977-10	2017	AD treatment significantly reduced the production of serum anti-CII, TNFalpha, IL-1beta, and IL-6.	andrographolide	0-2	interleukin 1 beta	Homo sapiens	79-87
28536017-9	2017	In contrast, on bone marrow derived macrophages, C4S, C6S, BT and PT-CS reduced the LPS-induced liberation of TNF-alpha, IL-6, IL-1beta and NO, indicating that the RAW response to CS was different from that of primary macrophages.	pt-cs	66-71	interleukin 1 beta	Homo sapiens	127-135
28695367-3	2017	The aim of this study was to investigate the anti-inflammatory effects and mechanism of paeonol in IL-1beta-induced human OA chondrocytes as well as mice OA models.	paeonol	88-95	interleukin 1 beta	Homo sapiens	99-107
28536017-9	2017	In contrast, on bone marrow derived macrophages, C4S, C6S, BT and PT-CS reduced the LPS-induced liberation of TNF-alpha, IL-6, IL-1beta and NO, indicating that the RAW response to CS was different from that of primary macrophages.	Chondroitin Sulfates	69-71	interleukin 1 beta	Homo sapiens	127-135
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	35-62	interleukin 1 beta	Homo sapiens	86-94
28210810-0	2017	Was isoflurane the only cause of IL-1beta upregulation?	Isoflurane	4-14	interleukin 1 beta	Homo sapiens	33-41
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	64-68	interleukin 1 beta	Homo sapiens	86-94
28216434-8	2017	S aureus infection control in vivo and IL-1beta release from cells of patients with Muckle-Wells syndrome were impaired by ibrutinib.	ibrutinib	123-132	interleukin 1 beta	Homo sapiens	39-47
28216434-9	2017	Notably, IL-1beta processing and release from immune cells isolated from patients with cancer receiving ibrutinib therapy were reduced.	ibrutinib	104-113	interleukin 1 beta	Homo sapiens	9-17
29028430-12	2017	In LPS- and ATP-induced THP-1 macrophage cells, curcumin significantly suppressed the expression of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) at both RNA and protein levels.	Adenosine Triphosphate	12-15	interleukin 1 beta	Homo sapiens	100-118
28295583-6	2017	Pretreatment with a caspase-1 inhibitor, Z-YVAD-FMK, downregulated the mature IL-1beta expression enhanced by AMBN treatment in LPS-treated U937 cells.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	41-51	interleukin 1 beta	Homo sapiens	78-86
28295583-9	2017	An ERK1/2-selective inhibitor, U0126, suppressed expression of the IL-1beta gene as well as its protein expression in U937 cells treated with LPS and AMBN.	U 0126	31-36	interleukin 1 beta	Homo sapiens	67-75
28871048-4	2017	Under specific experimental conditions, secretion of IL-1beta and FGF2 is triggered by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]-dependent formation of pores across the plasma membrane.	Phosphatidylinositol 4,5-Diphosphate	87-124	interleukin 1 beta	Homo sapiens	53-61
28871048-4	2017	Under specific experimental conditions, secretion of IL-1beta and FGF2 is triggered by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]-dependent formation of pores across the plasma membrane.	pi(4,5)p2	126-135	interleukin 1 beta	Homo sapiens	53-61
29026538-5	2017	Little is known about CSF concentration of IL-1beta in ewes and its correlation with plasma during inflammation as well as melatonin action on the concentration of IL-1beta in blood plasma and the CSF, and brain barriers permeability in early stage of lipopolysaccharide (LPS)-induced inflammation.	Melatonin	123-132	interleukin 1 beta	Homo sapiens	164-172
29026538-10	2017	RESULTS: Before LPS administration, IL-1beta was on the level of 62.0 +- 29.7 pg/mL and 66.4 +- 32.1 pg/mL in plasma and 26.2 +- 5.4 pg/mL and 21.3 +- 8.7 pg/mL in the CSF in sham- and melatonin-implanted group, respectively.	Melatonin	185-194	interleukin 1 beta	Homo sapiens	36-44
29028430-12	2017	In LPS- and ATP-induced THP-1 macrophage cells, curcumin significantly suppressed the expression of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) at both RNA and protein levels.	Adenosine Triphosphate	12-15	interleukin 1 beta	Homo sapiens	120-128
29028430-12	2017	In LPS- and ATP-induced THP-1 macrophage cells, curcumin significantly suppressed the expression of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) at both RNA and protein levels.	Curcumin	48-56	interleukin 1 beta	Homo sapiens	100-118
29028430-12	2017	In LPS- and ATP-induced THP-1 macrophage cells, curcumin significantly suppressed the expression of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) at both RNA and protein levels.	Curcumin	48-56	interleukin 1 beta	Homo sapiens	120-128
29056256-0	2017	Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1beta secretion in human trophoblasts.	Glyburide	0-13	interleukin 1 beta	Homo sapiens	51-59
28345770-5	2017	The objectives were to determine the effects of 1,25D3 or a non-calcemic analog, 20-hydroxyvitamin D3 -20(OH)D3 or 20D3-on IL-1beta-stimulated IL-6 and IL-8 production, and NF-kappaB and MAPK/AP-1 activation, by human gingival fibroblasts.	20-hydroxyvitamin d3 -20(oh)d3	81-111	interleukin 1 beta	Homo sapiens	123-131
29056256-6	2017	Treatment with either LPS or nigericin stimulated IL-1beta secretion, whereas pretreatment with the ATP-sensitive K+ channel inhibitor glibenclamide, the Rho-associated coiled-coil kinase inhibitor Y-27632, or a caspase-1 inhibitor significantly decreased nigericin-induced IL-1beta secretion.	Nigericin	29-38	interleukin 1 beta	Homo sapiens	50-58
29056256-6	2017	Treatment with either LPS or nigericin stimulated IL-1beta secretion, whereas pretreatment with the ATP-sensitive K+ channel inhibitor glibenclamide, the Rho-associated coiled-coil kinase inhibitor Y-27632, or a caspase-1 inhibitor significantly decreased nigericin-induced IL-1beta secretion.	Nigericin	29-38	interleukin 1 beta	Homo sapiens	274-282
29056256-7	2017	In addition, dibutyryl-cAMP, which induces trophoblast differentiation, decreased expression of NLRP3, caspase-1, and IL-1beta.	Bucladesine	13-27	interleukin 1 beta	Homo sapiens	118-126
29056256-8	2017	These findings suggest that trophoblasts can secrete IL-1beta through the NLRP3/caspase-1 pathway, which is suppressed by glibenclamide, and that the TLR4-mediated NLRP3 inflammasome pathway is more likely to be stimulated in undifferentiated than differentiated trophoblasts.	Glyburide	122-135	interleukin 1 beta	Homo sapiens	53-61
28849141-7	2017	H2O2-induced injury was associated with enhancing the levels of inflammatory cytokines, tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1beta in the cultured HBMECs, which were attenuated by TSG treatment.	Hydrogen Peroxide	0-4	interleukin 1 beta	Homo sapiens	140-148
28731170-0	2017	Isorhamnetin inhibits IL-1beta-induced expression of inflammatory mediators in human chondrocytes.	3-methylquercetin	0-12	interleukin 1 beta	Homo sapiens	22-30
28731170-5	2017	Pretreatment with ISH inhibited the IL-1beta-stimulated synthesis of NO and prostaglandin E2 induced by IL-1beta, in addition to the expression of inducible nitric oxide synthase and prostaglandin G/H synthase 2 in chondrocytes.	Dinoprostone	76-92	interleukin 1 beta	Homo sapiens	36-44
28731170-5	2017	Pretreatment with ISH inhibited the IL-1beta-stimulated synthesis of NO and prostaglandin E2 induced by IL-1beta, in addition to the expression of inducible nitric oxide synthase and prostaglandin G/H synthase 2 in chondrocytes.	Dinoprostone	76-92	interleukin 1 beta	Homo sapiens	104-112
28988613-5	2017	RESULTS: APAP administration increased serum creatinine, urea, uric acid, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) levels compared to control group.	Acetaminophen	9-13	interleukin 1 beta	Homo sapiens	119-136
28962697-8	2017	RESULTS: PTX preferentially inhibited placental expression and production of LPS-induced pro-inflammatory cytokines including TNF-alpha (25461 vs. 1908 pg/ml, p &lt; 0.001), IL-1beta (2921 vs. 1067 pg/ml, p &lt; 0.001) and IFN-gamma (2190 vs 427 pg/ml, p &lt; 0.001) with relative preservation of anti-inflammatory mediators.	Pentoxifylline	9-12	interleukin 1 beta	Homo sapiens	174-182
28988613-5	2017	RESULTS: APAP administration increased serum creatinine, urea, uric acid, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) levels compared to control group.	Acetaminophen	9-13	interleukin 1 beta	Homo sapiens	138-146
28870124-7	2017	Similarly, the expression of NLRP3 and caspase-1 p10 and the release of IL-1beta and IL-18 were significantly increased after ZnO-NPs treatment, which indicated that the NLRP3 inflammasome was activated by ZnO-NPs.	Zinc Oxide	126-129	interleukin 1 beta	Homo sapiens	72-80
28666365-4	2017	Chronic 30 mg/l CdCl2 treatment elevated murine blood Cd level comparable to that of low dose Cd-exposed humans, had no effect on blood total and differential leukocyte counts, but reduced neutrophil infiltration, chemokines (CXCL1 and CXCL2), and proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) expression in wounded tissue at early stage after injury.	Cadmium Chloride	16-21	interleukin 1 beta	Homo sapiens	285-293
28666365-4	2017	Chronic 30 mg/l CdCl2 treatment elevated murine blood Cd level comparable to that of low dose Cd-exposed humans, had no effect on blood total and differential leukocyte counts, but reduced neutrophil infiltration, chemokines (CXCL1 and CXCL2), and proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) expression in wounded tissue at early stage after injury.	Cadmium	16-18	interleukin 1 beta	Homo sapiens	285-293
29132841-6	2017	Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P&lt;.01 and P&lt;.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds.	Folic Acid	13-16	interleukin 1 beta	Homo sapiens	166-174
28870124-10	2017	Furthermore, the ability of ZnO-NPs to increase the production of IL-1beta and IL-18 was significantly inhibited by GEL.	Zinc Oxide	28-31	interleukin 1 beta	Homo sapiens	66-74
28963466-3	2017	TNFalpha and IL-1beta induced autophagy markers in human umbilical vein endothelial cells and inhibition of autophagy by 3-methyladenine (3-MA) blocked adhesion of Jurkat lymphocytes.	3-methyladenine	121-136	interleukin 1 beta	Homo sapiens	13-21
28412475-9	2017	Moreover, pre-treatment with L-NAME reversed the effect of LQFM-021 on NO, leukocyte migration, and the TNF-alpha and IL-1beta levels.	NG-Nitroarginine Methyl Ester	29-35	interleukin 1 beta	Homo sapiens	118-126
28954414-0	2017	Alpha-Lipoic Acid Downregulates IL-1beta and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells.	Thioctic Acid	0-17	interleukin 1 beta	Homo sapiens	32-40
28954414-4	2017	These results prompted us to ask whether ALA-induced repression of IL-1b and IL-6 was dependent on DNA methylation.	Thioctic Acid	41-44	interleukin 1 beta	Homo sapiens	67-72
28954414-8	2017	These results reinforce previous findings indicating that IL-1b and IL-6 undergo DNA methylation-dependent modulation in neural models and pave the road to study the epigenetic mechanisms triggered by ALA.	Thioctic Acid	201-204	interleukin 1 beta	Homo sapiens	58-63
28975158-2	2017	We found that PA-MSHA had a strong ability to activate pro-inflammatory cytokines such as IL-1beta, IL-6 and TNF-alpha.	pa-msha	14-21	interleukin 1 beta	Homo sapiens	90-98
29042009-0	2017	Identification of new CpG oligodeoxynucleotide motifs that induce expression of interleukin-1beta and nitric oxide in avian macrophages.	Oligodeoxyribonucleotides	26-46	interleukin 1 beta	Homo sapiens	80-97
29042009-4	2017	We synthesized 256 CpG oligodeoxynucleotides (CpG-ODNs) each containing triplicates of a unique hexamer CpG-motif and tested their ability to induce expression of pro-inflammatory cytokine IL-1beta in avian macrophages using q-RT PCR in four rounds of screening assays.	Oligodeoxyribonucleotides	23-44	interleukin 1 beta	Homo sapiens	189-197
29179489-0	2017	Saikosaponin A inhibits IL-1beta-induced inflammatory mediators in human osteoarthritis chondrocytes by activating LXRalpha.	saikosaponin D	0-14	interleukin 1 beta	Homo sapiens	24-32
29179489-7	2017	The results showed that SSa inhibited IL-1beta-induced PGE2 and NO production in a concentration-dependent manner.	Dinoprostone	55-59	interleukin 1 beta	Homo sapiens	38-46
28963466-3	2017	TNFalpha and IL-1beta induced autophagy markers in human umbilical vein endothelial cells and inhibition of autophagy by 3-methyladenine (3-MA) blocked adhesion of Jurkat lymphocytes.	3-methyladenine	138-142	interleukin 1 beta	Homo sapiens	13-21
28914761-0	2017	Flavonolignans Inhibit IL1-beta-Induced Cross-Talk between Blood Platelets and Leukocytes.	Flavonolignans	0-14	interleukin 1 beta	Homo sapiens	23-31
28935932-6	2017	CBD significantly attenuated the alcohol feeding-induced serum transaminase elevations, hepatic inflammation (mRNA expressions of TNFalpha, MCP1, IL1beta, MIP2 and E-Selectin, and neutrophil accumulation), oxidative/nitrative stress (lipid peroxidation, 3-nitrotyrosine formation, and expression of reactive oxygen species generating enzyme NOX2).	Alcohols	33-40	interleukin 1 beta	Homo sapiens	146-153
28539262-6	2017	In contrast, the TLR4 signaling inhibitor TAK-242 abrogates LPS-induced TNF and IL-1beta secretion, but not pyroptotic cell death.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	42-49	interleukin 1 beta	Homo sapiens	80-88
28539262-9	2017	Additionally, Pep19-2.5 completely abolished IL-1beta release induced by LPS/ATP in macrophages via canonical inflammasome activation.	Adenosine Triphosphate	77-80	interleukin 1 beta	Homo sapiens	45-53
28970837-0	2017	Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1beta Secretion via Transcription Factor EB in Human Monocytic Cells.	Glucose	40-47	interleukin 1 beta	Homo sapiens	57-74
28914761-3	2017	The aim of our study is to investigate the effect of flavonolignans (silybin, silychristin and silydianin) on the IL-1beta-induced interaction between platelets and leukocytes, as well as on the expression and the secretion of pro-inflammatory factors.	Flavonolignans	53-67	interleukin 1 beta	Homo sapiens	114-122
28914761-3	2017	The aim of our study is to investigate the effect of flavonolignans (silybin, silychristin and silydianin) on the IL-1beta-induced interaction between platelets and leukocytes, as well as on the expression and the secretion of pro-inflammatory factors.	Silybin	69-76	interleukin 1 beta	Homo sapiens	114-122
28914761-3	2017	The aim of our study is to investigate the effect of flavonolignans (silybin, silychristin and silydianin) on the IL-1beta-induced interaction between platelets and leukocytes, as well as on the expression and the secretion of pro-inflammatory factors.	silychristin	78-90	interleukin 1 beta	Homo sapiens	114-122
28914761-3	2017	The aim of our study is to investigate the effect of flavonolignans (silybin, silychristin and silydianin) on the IL-1beta-induced interaction between platelets and leukocytes, as well as on the expression and the secretion of pro-inflammatory factors.	silydianin	95-105	interleukin 1 beta	Homo sapiens	114-122
29254155-0	2017	Casticin inhibits interleukin-1beta-induced ICAM-1 and MUC5AC expression by blocking NF-kappaB, PI3K-Akt, and MAPK signaling in human lung epithelial cells.	casticin	0-8	interleukin 1 beta	Homo sapiens	18-35
29254155-3	2017	A549 cells were treated with various concentrations of casticin (5-20 muM), and an inflammatory response was triggered with interleukin (IL)-1beta cytokines.	casticin	55-63	interleukin 1 beta	Homo sapiens	124-146
29254155-8	2017	These results provide evidence that casticin has an anti-inflammatory effect by blocking proinflammatory cytokine, chemokine, and ICAM-1 expression via suppression of the PI3K/Akt, NF-kappaB, and MAPK signaling pathways in IL-1beta-stimulated inflammatory pulmonary epithelial cells.	casticin	36-44	interleukin 1 beta	Homo sapiens	223-231
28914761-9	2017	We observed that in a dose-dependent manner, silybin and silychristin inhibit the IL-1beta-induced formation of blood platelet-leukocyte aggregates in whole blood samples, as well as the production of pro-inflammatory cytokines-IL-2, TNF, INF-alpha, and INF-gamma.	Silybin	45-52	interleukin 1 beta	Homo sapiens	82-90
28735730-6	2017	RESULTS: In IL-1beta-treated SW1353 cells, impressic acid significantly and concentration-dependently inhibited MMP-13 expression at 0.5-10muM.	3,11-dihydroxylup-20(29)-en-28-oic acid	43-57	interleukin 1 beta	Homo sapiens	12-20
28914761-9	2017	We observed that in a dose-dependent manner, silybin and silychristin inhibit the IL-1beta-induced formation of blood platelet-leukocyte aggregates in whole blood samples, as well as the production of pro-inflammatory cytokines-IL-2, TNF, INF-alpha, and INF-gamma.	silychristin	57-69	interleukin 1 beta	Homo sapiens	82-90
28914761-10	2017	Additionally, these two flavonolignans abolished the IL-1beta-induced expression of mRNA for IFN-gamma and TNF.	Flavonolignans	24-38	interleukin 1 beta	Homo sapiens	53-61
28650029-8	2017	The present study shows that the amine-modified MSNs could encapsulate BA and BE, and nano-encapsulation greatly enhances the drug delivery rate and prolongs the release of BA and BE up to 216 h. Moreover, both Nano-BA and Nano-BE could be internalized by hGECs and retained intracellularly in nanoparticle-free media for at least 24 h. Note that Nano-BE pre-treatment effectively down-regulates the IL-1beta-induced expression of IL-6 and IL-8 in hGECs.	Amines	33-38	interleukin 1 beta	Homo sapiens	400-408
28887458-3	2017	Interleukin(IL)-1beta treatment markedly induced prostaglandin biosynthesis in diseased compared to healthy tendon cells, and up regulated the formation of several pro-resolving mediators including 15-epi-LXA4 and MaR1.	Prostaglandins	49-62	interleukin 1 beta	Homo sapiens	0-21
28955228-13	2017	AOS treatment resulted in the increase in serum levels of SOD, GSH, HDL-C, and reduction in the levels of interleukin-1 (IL-1) beta and IL-6; the ratios of AST/ALT; and triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol LDL-C, and malondialdehyde (MDA) (P &lt; 0.05).	D-(+)-ALLOSE	0-3	interleukin 1 beta	Homo sapiens	121-131
29259717-3	2017	Recent studies suggest that cholesterol crystals play a pivotal role in activation of NLRP3 inflammasomes, which regulate caspase-1 activation and the subsequent processing of IL-1beta, in atherosclerotic lesions.	Cholesterol	28-39	interleukin 1 beta	Homo sapiens	176-184
28887458-4	2017	Incubation of IL-1beta stimulated healthy tendon cells with 15-epi-LXA4 or MaR1 down-regulated PGE2 and PGD2 production.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	14-22
28887458-4	2017	Incubation of IL-1beta stimulated healthy tendon cells with 15-epi-LXA4 or MaR1 down-regulated PGE2 and PGD2 production.	Prostaglandin D2	104-108	interleukin 1 beta	Homo sapiens	14-22
28924549-7	2017	In addition, the levels of TNF-alpha and IL-1beta secreted from astrocytes after OGD/R were markedly reduced after d,l-PHPB treatment, which was mainly due to the suppression of phosphorylated p38.	d,l-phpb	115-123	interleukin 1 beta	Homo sapiens	41-49
28660311-0	2017	Astragalus polysaccharides inhibits cell growth and pro-inflammatory response in IL-1beta-stimulated fibroblast-like synoviocytes by enhancement of autophagy via PI3K/AKT/mTOR inhibition.	Polysaccharides	11-26	interleukin 1 beta	Homo sapiens	81-89
29066482-0	2017	The Effect of Metformin on the Expression of GPR109A, NF-kappaB and IL-1beta in Peripheral Blood Leukocytes from Patients with Type 2 Diabetes Mellitus.	Metformin	14-23	interleukin 1 beta	Homo sapiens	68-76
28398068-4	2017	Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-gamma, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-beta, IL-1, and IL-17, compared to their placebo counterparts.	l-gsh	46-51	interleukin 1 beta	Homo sapiens	113-117
28662432-9	2017	1,25-Vitamin D3 stimulation induced cathelicidin in PKDL-BT patients through involvement of TLR2/IL-1beta, but not TLR4.	1,25-vitamin d3	0-15	interleukin 1 beta	Homo sapiens	97-105
28631090-9	2017	Pretreatment with topical pseudoceramide protected against UVB-induced upregulation of IL-1beta, IL-6, and TNF-alpha transcription and reduced susceptibility to erythema following UVB.	pseudoceramide	26-40	interleukin 1 beta	Homo sapiens	87-95
28738524-10	2017	miR-125b overexpression statistically increased the expression of TNF-alpha, IL-6, IL-1beta and p-p65 (P&lt;0.05 or P&lt;0.01), but markedly decreased IkappaB-alpha (P&lt;0.05).	mir-125b	0-8	interleukin 1 beta	Homo sapiens	83-91
28738524-12	2017	Additionally, there were strong positive relationships between miR-125b and TNF-alpha (R2=0.7569, P&lt;0.000), IL-6 (R2=0.8479, P&lt;0.000), and IL-1beta (R2=0.8037, P&lt;0.000).	mir-125b	63-71	interleukin 1 beta	Homo sapiens	145-153
28511026-4	2017	The results showed that hydrocortisone at the dose of 127 ng/mL (equivalent to endogenous basal level of GCs) inhibited LPS (100 ng/mL)-induced productions of TNF-alpha and IL-1beta in cardiac fibroblasts.	Hydrocortisone	24-38	interleukin 1 beta	Homo sapiens	173-181
28666239-0	2017	Cryptotanshinone protects against IL-1beta-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.	cryptotanshinone	0-16	interleukin 1 beta	Homo sapiens	34-42
28666239-9	2017	We found that CTS significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5.	cryptotanshinone	14-17	interleukin 1 beta	Homo sapiens	46-54
28651232-7	2017	Silymarin treatment significantly down regulated the inflammatory responses by suppressing NF-kappaB-p65 levels and inflammasome-mediated caspase-1/IL-1beta expressions.	Silymarin	0-9	interleukin 1 beta	Homo sapiens	148-156
28919708-11	2017	AOS treatment reduced the levels of miR-29b, TLR4, mitogen-activated protein kinase (MAPK), nuclear factor kappa B (NF-kappa B), interleukin 1 (IL-1) beta, and interleukin 6 (IL-6).	D-(+)-ALLOSE	0-3	interleukin 1 beta	Homo sapiens	144-154
28692879-0	2017	Anti-inflammatory effects of pitavastatin in interleukin-1beta-induced SW982 human synovial cells.	pitavastatin	29-41	interleukin 1 beta	Homo sapiens	45-62
28692879-6	2017	These findings suggest that the mechanism underlying the inhibitory effects of pitavastatin on IL-1beta-induced IL-6 and IL-8 release might be mediated by the suppression of mitogen-activated protein kinase (MAPK), Akt, and nuclear factor-kappaB (NF-kappaB) signaling pathways.	pitavastatin	79-91	interleukin 1 beta	Homo sapiens	95-103
28666239-9	2017	We found that CTS significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5.	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	46-54
28859441-7	2017	Results: Baicalein co-administration markedly attenuated colistin-induced oxidative and nitrative stress, apoptosis, the infiltration of inflammatory cells, and caused decreases in IL-1beta and TNF-alpha levels (all P &lt; 0.05 or 0.01) in the kidney tissues.	baicalein	9-18	interleukin 1 beta	Homo sapiens	181-189
28666239-11	2017	Immunofluorescence staining demonstrated that CTS could suppress IL-1beta-induced phosphorylation of p65 nuclear translocation.	cryptotanshinone	46-49	interleukin 1 beta	Homo sapiens	65-73
28684418-7	2017	The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and IL-6 release in HG+IL-1beta-treated cells than in NG+IL-1beta-treated cells.	Cobalt	17-23	interleukin 1 beta	Homo sapiens	98-106
28684418-7	2017	The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and IL-6 release in HG+IL-1beta-treated cells than in NG+IL-1beta-treated cells.	Cobalt	17-23	interleukin 1 beta	Homo sapiens	132-140
28684418-5	2017	HG-exposed, IL-1beta-stimulated chondrocytes had lower Nrf-2 levels in vitro, particularly in the nuclear fraction, than chondrocytes exposed to normal glucose (NG).	Glucose	152-159	interleukin 1 beta	Homo sapiens	12-20
28684418-7	2017	The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and IL-6 release in HG+IL-1beta-treated cells than in NG+IL-1beta-treated cells.	protoporphyrin IX	24-41	interleukin 1 beta	Homo sapiens	98-106
28684418-7	2017	The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and IL-6 release in HG+IL-1beta-treated cells than in NG+IL-1beta-treated cells.	Dinoprostone	70-74	interleukin 1 beta	Homo sapiens	98-106
29075409-9	2017	CONCLUSIONS: In patients with diabetes and periodontal disease, treatment with topical melatonin was associated with a significant improvement in the gingival index and in pocket depth, and a statistically significant reduction in concentrations of interleukin-1beta, interleukin-6 and prostaglandin E2 in gingival crevicular fluid.	Melatonin	87-96	interleukin 1 beta	Homo sapiens	249-266
28547650-8	2017	Leu-Leu-OMe increased the expression of NLRP3, IL-1beta, and IL-18 in HUVECs.	leucyl-leucine-methyl ester	0-11	interleukin 1 beta	Homo sapiens	47-55
29491585-0	2017	Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1beta levels in patients with chronic periodontitis: A clinico-immunological study.	omega-3 polyunsaturated fatty acids	41-76	interleukin 1 beta	Homo sapiens	131-148
28714008-2	2017	Astragaloside IV (AST) has been proven to possess an antiarthritic effect by preventing interleukin (IL)-1beta-induced cartilage damage.	astragaloside A	0-16	interleukin 1 beta	Homo sapiens	88-110
28829242-12	2017	In conclusion, BA suppresses the inflammatory responses of human chondrocytes to IL-1beta stimulation, and NF-kappaB signaling may be involved in the mechanisms of BA functions.	baicalin	15-17	interleukin 1 beta	Homo sapiens	81-89
28694089-8	2017	In an OVA-induced AR animal model, the increased levels of nose rubbing, histamine, immunoglobulin E, TSLP, and interleukin IL-1beta were dramatically reduced by the administration of taurine.	Taurine	184-191	interleukin 1 beta	Homo sapiens	124-132
28422402-4	2017	Our results showed that GP dose-dependently inhibited IL-1beta-induced NO and PGE2 production in human OA chondrocytes.	Dinoprostone	78-82	interleukin 1 beta	Homo sapiens	54-62
28051087-3	2017	Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells.	Medroxyprogesterone Acetate	74-101	interleukin 1 beta	Homo sapiens	229-236
28714008-8	2017	In contrast, after autophagy inhibited by 3-methyladenine, chondrocyte apoptosis was further increased under IL-1beta treatment.	3-methyladenine	42-57	interleukin 1 beta	Homo sapiens	109-117
28688942-10	2017	Treatment of chondrocytes with Wogonin resulted in significant suppression of IL-1beta-mediated induction of ROS.	ros	109-112	interleukin 1 beta	Homo sapiens	78-86
28958187-9	2017	At 6 h, n-Zn, b-Zn and n-Ag induced various immunity related genes associating to pattern recognition (including toll-like receptor), macrophage maturation, inflammatory response (TNF and IL-1beta), chemotaxis (CXCL8) and leucocyte migration (CXCL2-3 and CXCL14).	n-zn	8-12	interleukin 1 beta	Homo sapiens	188-196
28958187-9	2017	At 6 h, n-Zn, b-Zn and n-Ag induced various immunity related genes associating to pattern recognition (including toll-like receptor), macrophage maturation, inflammatory response (TNF and IL-1beta), chemotaxis (CXCL8) and leucocyte migration (CXCL2-3 and CXCL14).	b-zn	14-18	interleukin 1 beta	Homo sapiens	188-196
28958187-9	2017	At 6 h, n-Zn, b-Zn and n-Ag induced various immunity related genes associating to pattern recognition (including toll-like receptor), macrophage maturation, inflammatory response (TNF and IL-1beta), chemotaxis (CXCL8) and leucocyte migration (CXCL2-3 and CXCL14).	Acetylglucosamine	23-27	interleukin 1 beta	Homo sapiens	188-196
28606428-4	2017	TiO2 particles at 10mug/ml showed increased mRNA expression of inflammatory cytokines (TNFalpha, IL-1beta and IL-6), inflammatory mediators (iNOS and COX-2) and transcription factor (NFkappaB) similar to that of LPS stimulated macrophages.	titanium dioxide	0-4	interleukin 1 beta	Homo sapiens	97-105
28606428-6	2017	In addition, TiO2 particles at 10mug/ml also increased the production of inflammatory cytokines (TNFalpha, IL-1beta and IL-6) and intracellular ROS levels in RAW 264.7 macrophages similar to that of LPS stimulated macrophages.	titanium dioxide	13-17	interleukin 1 beta	Homo sapiens	107-115
28851291-4	2017	In this study, we focused on an anti-inflammatory agent, honokiol, which is isolated from an herb, investigated the potential effects on human umbilical cord derived mesenchymal stem cells (hUC-MSCs) in IL-1beta stimulation.	honokiol	57-65	interleukin 1 beta	Homo sapiens	203-211
28851291-13	2017	Honokiol relieved these negative impacts induced by IL-1beta and suppressed Nuclear factor-kappaB (NF-kappaB) pathway by downregulating expression of p-IKKalpha/beta, p-IkappaBalpha and p-p65 in dose-dependent and time-dependent manner.	honokiol	0-8	interleukin 1 beta	Homo sapiens	52-60
28851291-14	2017	CONCLUSIONS: Honokiol improved cell survival and chondrogenesis of hUC-MSCs and inhibited IL-1beta-induced inflammatory response, which suggested that combination of anti-inflammation and stem cell can be a novel strategy for better cartilage repair.	honokiol	13-21	interleukin 1 beta	Homo sapiens	90-98
28645612-8	2017	The direct participation of IL-1beta in these processes was validated by blockage of the cytokine-induced signaling pathway by wortmannin inactivation of the effectors PI3K/AKT.	Wortmannin	127-137	interleukin 1 beta	Homo sapiens	28-36
28711657-5	2017	Kaempferol decreased the production and mRNA expression of pro-inflammatory cytokines, in this case thymic stromal lymphopoietin (TSLP), IL-1beta, tumor necrosis factor (TNF)-alpha, and IL-8.	kaempferol	0-10	interleukin 1 beta	Homo sapiens	137-145
28711657-7	2017	Kaempferol also ameliorated the lipopolysaccharide-induced production of the inflammatory mediators TSLP, IL-1beta, TNF-alpha, IL-8, and nitric oxide of macrophage-like cells differentiated by IL-32.	kaempferol	0-10	interleukin 1 beta	Homo sapiens	106-114
28878677-4	2017	Our results showed that Teuvincenone F attenuated K63-linked ubiquitination of NF-kappaB-essential modulator (NEMO, also known as IKKgamma) to suppress LPS-induced phosphorylation of NF-kappaB, and inhibited mRNA expression of IL-1beta, IL-6, TNF-alpha, and NLRP3.	teuvincenone	24-36	interleukin 1 beta	Homo sapiens	227-235
29245931-6	2017	Furthermore, silibinin dramatically suppressed IL-1beta-stimulated phosphatidylinositol 3 kinase/ protein kinase B (PI3K/Akt) phosphorylation and nuclear factor-kappa B (NF-kB) activation in human OA chondrocytes.	Silybin	13-22	interleukin 1 beta	Homo sapiens	47-55
28643827-7	2017	We also studied the effect of sulfated alginate on the ability of IL-1beta to stimulate inflammatory genes in human chondrocytes and found decreased expression of the pro-inflammatory markers IL-6 and CXCL8, which inversely correlated with the sulfation degree.	Alginates	39-47	interleukin 1 beta	Homo sapiens	66-74
28878677-5	2017	In addition, we found that decreased NLRP3 expression by Teuvincenone F suppressed NLRP3 inflammasome activation and IL-1beta/IL-18 maturation.	teuvincenone	57-69	interleukin 1 beta	Homo sapiens	117-125
28515391-7	2017	After pre-incubation with AGEs, nano-silica treatment (well known as an inflammasome activator) increased IL-1beta secretion in placental cells.	Silicon Dioxide	37-43	interleukin 1 beta	Homo sapiens	106-114
28583763-10	2017	The inflammatory cytokine interleukin-1 beta was present in the medium and alginate associated matrix.	Alginates	75-83	interleukin 1 beta	Homo sapiens	26-44
28819322-7	2017	The upregulation of IL-1beta- or Ad-Nampt-induced catabolic factors was significantly abrogated by the intracellular NAMPT (iNAMPT) inhibitor, FK866 or by the sirtuin (SIRT) inhibitor, nicotinamide (NIC).	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	143-148	interleukin 1 beta	Homo sapiens	20-28
28819322-7	2017	The upregulation of IL-1beta- or Ad-Nampt-induced catabolic factors was significantly abrogated by the intracellular NAMPT (iNAMPT) inhibitor, FK866 or by the sirtuin (SIRT) inhibitor, nicotinamide (NIC).	Niacinamide	185-197	interleukin 1 beta	Homo sapiens	20-28
28662965-7	2017	Similar to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin, however, GXB suppressed the IL-1beta-induced mRNA level of SAA1, an acute-phase response gene that is up-regulated AhR-dependently but XRE-independently.	Polychlorinated Dibenzodioxins	27-62	interleukin 1 beta	Homo sapiens	92-100
28662965-7	2017	Similar to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin, however, GXB suppressed the IL-1beta-induced mRNA level of SAA1, an acute-phase response gene that is up-regulated AhR-dependently but XRE-independently.	gerontoxanthone B	73-76	interleukin 1 beta	Homo sapiens	92-100
28479300-6	2017	As an in vitro model of early diabetic retinopathy, human retinal pericytes were exposed to high glucose (25mM, 48h) that caused a significant (p&lt;0.05) release of IL-1beta and LDH.	Glucose	97-104	interleukin 1 beta	Homo sapiens	166-174
28479300-7	2017	The block of P2X7R by JNJ47965567 significantly (p&lt;0.05) reverted the damage elicited by high glucose, detected as IL-1beta and LDH release.	Glucose	97-104	interleukin 1 beta	Homo sapiens	118-126
28532672-0	2017	Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1beta signaling in rheumatoid arthritis synovial fibroblasts.	Catechin	85-94	interleukin 1 beta	Homo sapiens	98-106
28319722-5	2017	Our results demonstrated that BPS exposure induced pro-inflammatory phenotype by activating the immuno-related cytokines which include TNF-alpha, IL-1beta and IL-6, modulating metabolic pathways which include glycolytic, glutathione (GSH), sphingomyelin (SM)-ceramide (Cer), glycerophospholipids (GPs) and glycerolipids (GLs).	bis(4-hydroxyphenyl)sulfone	30-33	interleukin 1 beta	Homo sapiens	146-154
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	Catechin	29-38	interleukin 1 beta	Homo sapiens	112-120
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	epigallocatechin gallate	59-63	interleukin 1 beta	Homo sapiens	112-120
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	gallocatechol	59-62	interleukin 1 beta	Homo sapiens	112-120
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	ec	74-76	interleukin 1 beta	Homo sapiens	112-120
28532672-4	2017	When we looked at the expression of key signaling proteins in the IL-1beta signaling pathway, we found all the tested catechins could inhibit TAK-1 activity.	Catechin	118-127	interleukin 1 beta	Homo sapiens	66-74
28799079-0	2017	Protective effects of paeonol on inflammatory response in IL-1beta-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-kappaB pathway.	paeonol	22-29	interleukin 1 beta	Homo sapiens	58-66
28798291-4	2017	RESULTS After six hours, 12 hours, and 24 hours of high glucose stimulation, the secretion of IL-1beta in human glomerular mesangial cells, compared to unstimulated cells, was 1.85-fold, 3.04-fold, and 4.14-fold; the expression of NLRP3 increased by 2.20-fold, 4.62-fold, and 8.32-fold; and the expression of caspase-1 was increased by 1.60-fold, 2.72-fold, and 3.67-fold.	Glucose	56-63	interleukin 1 beta	Homo sapiens	94-102
28799079-5	2017	In this study, anti-inflammatory effects of paeonol were detected in interleukin-1beta (IL-1beta)-treated HFLS-RA.	paeonol	44-51	interleukin 1 beta	Homo sapiens	69-86
28799079-5	2017	In this study, anti-inflammatory effects of paeonol were detected in interleukin-1beta (IL-1beta)-treated HFLS-RA.	paeonol	44-51	interleukin 1 beta	Homo sapiens	88-96
28799079-7	2017	Pretreatment with paeonol significantly suppressed the production of pro-inflammatory TNF-alpha, IL-6 and IL-1beta, and the expressions of matrix metalloproteinase-1/-3 in vitro and in vivo.	paeonol	18-25	interleukin 1 beta	Homo sapiens	106-114
29392169-1	2017	Lipid-siRNA assemblies are modified with photo-responsive polymers to enable spatiotemporally-controlled silencing of interleukin 1 beta (IL1beta) and cadherin 11 (CDH11), two genes that are essential drivers of maladaptive responses in human aortic adventitial fibroblasts (AoAFs).	Polymers	58-66	interleukin 1 beta	Homo sapiens	118-136
28797095-1	2017	BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1beta (IL-1beta) stimulated by monosodium urate (MSU) crystals.	Uric Acid	133-149	interleukin 1 beta	Homo sapiens	90-107
28797095-1	2017	BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1beta (IL-1beta) stimulated by monosodium urate (MSU) crystals.	Uric Acid	133-149	interleukin 1 beta	Homo sapiens	109-117
28797095-1	2017	BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1beta (IL-1beta) stimulated by monosodium urate (MSU) crystals.	Uric Acid	151-154	interleukin 1 beta	Homo sapiens	90-107
28797095-1	2017	BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1beta (IL-1beta) stimulated by monosodium urate (MSU) crystals.	Uric Acid	151-154	interleukin 1 beta	Homo sapiens	109-117
28797095-12	2017	CONCLUSIONS: ATP promotes the pathogenesis of gouty arthritis via increasing the secretion of IL-1 beta, and its receptor (P2X7R) function associated single nucleotide polymorphisms may be related to gouty arthritis, which indicates that ATP-P2X7R signaling pathway plays a significant regulatory role in the pathogenesis of gout.	Adenosine Triphosphate	13-16	interleukin 1 beta	Homo sapiens	94-103
28793896-2	2017	MEDI8968, a fully human monoclonal antibody, binds selectively to IL-1R1, inhibiting activation by IL-1alpha and IL-1beta.	medi8968	0-8	interleukin 1 beta	Homo sapiens	113-121
28779175-5	2017	Mitochondrial ROS then induces the translocation of CLICs to the plasma membrane for the induction of chloride efflux to promote NEK7-NLRP3 interaction, inflammasome assembly, caspase-1 activation, and IL-1beta secretion.	Reactive Oxygen Species	14-17	interleukin 1 beta	Homo sapiens	202-210
28779175-5	2017	Mitochondrial ROS then induces the translocation of CLICs to the plasma membrane for the induction of chloride efflux to promote NEK7-NLRP3 interaction, inflammasome assembly, caspase-1 activation, and IL-1beta secretion.	Chlorides	102-110	interleukin 1 beta	Homo sapiens	202-210
29392169-1	2017	Lipid-siRNA assemblies are modified with photo-responsive polymers to enable spatiotemporally-controlled silencing of interleukin 1 beta (IL1beta) and cadherin 11 (CDH11), two genes that are essential drivers of maladaptive responses in human aortic adventitial fibroblasts (AoAFs).	Polymers	58-66	interleukin 1 beta	Homo sapiens	138-145
28711708-7	2017	Ezetimibe and simvastatin combination treatment lowered fasting total cholesterol, LDLc and Lp(a) concentrations and Apo B/A1 ratio and suppressed the MNC expression of IL-1beta and CD68 (by 21 +- 7 and 24 +- 10, p &lt; 0.05) and the concentrations of LPS, CRP, FFA and IL-18 by 24 +- 7%, 32 +- 11%, 19 +- 8% 15 +- 4%, respectively, (p &lt; 0.05).	Ezetimibe	0-9	interleukin 1 beta	Homo sapiens	169-177
28570862-9	2017	IL-1beta production correlated negatively with Apo A1 and HDL-C. CD86 and TLR2 correlated positively with Chol:HDL-C but negatively with HDL-C and Apo A1:Apo B. Interestingly, CD163 expression correlated positively with Chol:HDL-C but negatively with Apo A1:Apo B.	chol	106-110	interleukin 1 beta	Homo sapiens	0-8
28570862-9	2017	IL-1beta production correlated negatively with Apo A1 and HDL-C. CD86 and TLR2 correlated positively with Chol:HDL-C but negatively with HDL-C and Apo A1:Apo B. Interestingly, CD163 expression correlated positively with Chol:HDL-C but negatively with Apo A1:Apo B.	chol	220-224	interleukin 1 beta	Homo sapiens	0-8
28252317-0	2017	Role for NLRP3 Inflammasome-mediated, IL-1beta-Dependent Responses in Severe, Steroid-Resistant Asthma.	Steroids	78-85	interleukin 1 beta	Homo sapiens	38-46
28252317-10	2017	MEASUREMENTS AND MAIN RESULTS: Chlamydia and Haemophilus infections increase NLRP3, caspase-1, IL-1beta responses that drive steroid-resistant neutrophilic inflammation and airway hyperresponsiveness.	Steroids	125-132	interleukin 1 beta	Homo sapiens	95-103
28252317-11	2017	Neutrophilic airway inflammation, disease severity, and steroid resistance in human asthma correlate with NLRP3 and IL-1beta expression.	Steroids	56-63	interleukin 1 beta	Homo sapiens	116-124
28252317-13	2017	Neutrophil depletion suppressed IL-1beta-induced steroid-resistant airway hyperresponsiveness.	Steroids	49-56	interleukin 1 beta	Homo sapiens	32-40
28711708-7	2017	Ezetimibe and simvastatin combination treatment lowered fasting total cholesterol, LDLc and Lp(a) concentrations and Apo B/A1 ratio and suppressed the MNC expression of IL-1beta and CD68 (by 21 +- 7 and 24 +- 10, p &lt; 0.05) and the concentrations of LPS, CRP, FFA and IL-18 by 24 +- 7%, 32 +- 11%, 19 +- 8% 15 +- 4%, respectively, (p &lt; 0.05).	Simvastatin	14-25	interleukin 1 beta	Homo sapiens	169-177
28198144-5	2017	The PE of EVOO decreased the frequency of CD69+ cells and the secretion of IFN-gamma, TNF-alpha, IL-6, IL-1beta, and IL-10.	evoo	10-14	interleukin 1 beta	Homo sapiens	103-111
28764778-11	2017	However, PBMC IL-6 and IL-1beta concentrations were increased at 0.05-0.2 mg/ml CLE but decreased at 0.4 mg/ml CLE (p &lt; 0.0001).	cle	80-83	interleukin 1 beta	Homo sapiens	23-31
28643873-9	2017	In vitro studies using cultured human astrocytes showed that interleukin (IL)-1beta-induced (immuno)proteasome gene expression could be attenuated by rapamycin.	Sirolimus	150-159	interleukin 1 beta	Homo sapiens	61-83
28646302-9	2017	Interleukin (IL)-1beta, IL-6, IL-8 and IL-10 levels in the serum all increased POST-1h (P &gt; 0.05) but returned to pre-exercise levels POST-1d.	Hydrogen	84-86	interleukin 1 beta	Homo sapiens	0-22
28364187-9	2017	We found that chrysin significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5; and degradation of aggrecan and collagen-II.	Dinoprostone	88-92	interleukin 1 beta	Homo sapiens	50-58
28829844-8	2017	Stabilization of DHFR-IkappaBalpha with TMP prevented IL-1alpha-, A2E-, LPS-, and TNFalpha-induced NFkappaB-mediated upregulation and release of the proinflammatory cytokines IL-1beta and IL-6 from ARPE-19 cells (by as much as 93%).	Trimethoprim	40-43	interleukin 1 beta	Homo sapiens	175-183
28586015-4	2017	The results indicated that Met, UC-II, CS, MSM and AO slightly or moderately suppressed the IL-1beta-stimulated IL-8 production by human synovial MH7A cells.	Chondroitin Sulfates	39-41	interleukin 1 beta	Homo sapiens	92-100
28477980-12	2017	In vivo studies indicated that the expression of SIRT1, SIRT6 was decreased and the expression of MCP-1, IL-6 and IL-1beta was increased in carotid collar-induced vascular inflammation.	carotid	140-147	interleukin 1 beta	Homo sapiens	114-122
28527816-10	2017	In addition, blocking NFkappaB signaling with the specific NFkappaB inhibitor PDTC (pyrrolidine dithiocarbamate) prevented IL-1beta-induced HUVEC activation enhanced by ADAR1 knockdown.	pyrrolidine dithiocarbamic acid	84-111	interleukin 1 beta	Homo sapiens	123-131
27996167-0	2017	Intracellular Chloride Concentration Changes Modulate IL-1beta Expression and Secretion in Human Bronchial Epithelial Cultured Cells.	Chlorides	14-22	interleukin 1 beta	Homo sapiens	54-62
27996167-6	2017	Here, varying the intracellular chloride concentration [Cl- ]i of IB3-1 CF bronchial epithelial cells, we show that IL-1beta mRNA expression and secretion are also under Cl- modulation.	Chlorides	32-40	interleukin 1 beta	Homo sapiens	116-124
27996167-10	2017	On the other hand, the IL-1beta secretion is still modulated by Cl- in the presence of IL-1RN, IL-1beta blocking antibody, or cycloheximide, suggesting that Cl- is affecting the IL-1beta maturation/secretion, which in turn starts an autocrine positive feedback loop.	Cycloheximide	126-139	interleukin 1 beta	Homo sapiens	23-31
27996167-11	2017	In conclusion, the Cl- anion acts as a second messenger for CFTR, modulating the IL-1beta maturation/secretion.	cl- anion	19-28	interleukin 1 beta	Homo sapiens	81-89
28552807-6	2017	The results showed that glycyrrhizin significantly suppressed LPS-induced TNF-alpha, IL-1beta, NO, and PGE2 production.	Glycyrrhizic Acid	24-36	interleukin 1 beta	Homo sapiens	85-93
28767589-4	2017	After fenofibrate treatment, serum IL-1beta, TNF-alpha, VEGF, and Lp-PLA2 significantly decreased in NPDR and PDR patients.Serum IL-1beta, TNF-alpha, VEGF, and Lp-PLA2 play an important role in occurrence and development of diabetic retinopathy.	Fenofibrate	6-17	interleukin 1 beta	Homo sapiens	35-43
28767589-4	2017	After fenofibrate treatment, serum IL-1beta, TNF-alpha, VEGF, and Lp-PLA2 significantly decreased in NPDR and PDR patients.Serum IL-1beta, TNF-alpha, VEGF, and Lp-PLA2 play an important role in occurrence and development of diabetic retinopathy.	Fenofibrate	6-17	interleukin 1 beta	Homo sapiens	129-137
28586061-0	2017	Chlorogenic acid prevents inflammatory responses in IL-1beta-stimulated human SW-1353 chondrocytes, a model for osteoarthritis.	Chlorogenic Acid	0-16	interleukin 1 beta	Homo sapiens	52-60
28586061-7	2017	The results indicated that CGA reversed IL-1beta-induced increases in iNOS/NO, IL-6, MMP-13 and COX-2/PGE2 production, and reversed the IL-1beta-mediated downregulation of collagen II.	Dinoprostone	102-106	interleukin 1 beta	Homo sapiens	40-48
28288151-5	2017	PTX markedly downregulated LPS-induced tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 levels in all age groups.	Pentoxifylline	0-3	interleukin 1 beta	Homo sapiens	68-90
28805975-8	2017	Furthermore, antofine also modulated the activation of AMPK and caspase-1, the key regulator in inflammasome-mediated IL-1beta maturation, in activated macrophage cells.	antofine	13-21	interleukin 1 beta	Homo sapiens	118-126
28095751-9	2017	Furthermore, engineered hADSCs demonstrated improved chondrogenic differentiation capacity in the presence of TNF-alpha or IL-1beta, as shown by superior production of glycosaminglycans in this inflammatory environment.	glycosaminglycans	168-185	interleukin 1 beta	Homo sapiens	123-131
28761045-6	2017	Here, we report that inhibiting NLRP3 with the selective inhibitor MCC950, blocked release of IL-1beta and the related cytokine IL-1alpha from primary human monocytes in response to S. typhimurium.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	67-73	interleukin 1 beta	Homo sapiens	94-102
28878946-0	2017	Supplemental N-acetylcysteine and other measures that boost intracellular glutathione can downregulate interleukin-1beta signalling: a potential strategy for preventing cardiovascular events?	Glutathione	74-85	interleukin 1 beta	Homo sapiens	103-120
28749447-5	2017	The internalization of the Fe3O4 NPs in Caco-2 cells was mediated by clathrin-related routes in both the control and an interleukin-1beta (IL-1beta)-induced inflammatory condition.	ferryl iron	27-32	interleukin 1 beta	Homo sapiens	120-137
28749447-5	2017	The internalization of the Fe3O4 NPs in Caco-2 cells was mediated by clathrin-related routes in both the control and an interleukin-1beta (IL-1beta)-induced inflammatory condition.	ferryl iron	27-32	interleukin 1 beta	Homo sapiens	139-147
28747177-10	2017	RESULTS: Positive correlations of DeltaCr were found with BUN, admission Cr, GRACE score, IL-1beta, IL-6, NT-ProBNP and age, and negative correlations with systolic blood pressure, mean-BP, diastolic-BP and LxA4.	Creatinine	39-41	interleukin 1 beta	Homo sapiens	90-98
28794655-4	2017	For this reason, we examined the effects of ADPbetas (ADP analog) on the expression and the release of IL-1beta, IL-6, and TNF-alpha.	Adenosine Diphosphate	44-47	interleukin 1 beta	Homo sapiens	103-111
28794655-7	2017	ADPbetas-evoked increase in Iba-1, IL-1beta, IL-6 and TNF-alpha mRNA expression was inhibited only partially by P2Y12 receptor antagonist MRS2395 or P2Y13 receptor antagonist MRS2211, respectively.	adenosine 5'-O-(2-thiodiphosphate)	0-8	interleukin 1 beta	Homo sapiens	35-43
28794655-10	2017	Further evidence indicated that P2Y12 and P2Y13 receptor-evoked increased gene expression of IL-1beta, IL-6 and TNF-alpha were inhibited by Y-27632 (ROCK inhibitor), SB203580 (P38MAPK inhibitor) and PDTC (NF-kappab inhibitor), respectively.	Y 27632	140-147	interleukin 1 beta	Homo sapiens	93-101
28794655-10	2017	Further evidence indicated that P2Y12 and P2Y13 receptor-evoked increased gene expression of IL-1beta, IL-6 and TNF-alpha were inhibited by Y-27632 (ROCK inhibitor), SB203580 (P38MAPK inhibitor) and PDTC (NF-kappab inhibitor), respectively.	SB 203580	166-174	interleukin 1 beta	Homo sapiens	93-101
28794655-11	2017	Subsequently, P2Y12 and P2Y13 receptor-evoked release of IL-1beta, IL-6 and TNF-alpha, were also inhibited by Y-27632, SB203580 and PDTC, respectively.	Y 27632	110-117	interleukin 1 beta	Homo sapiens	57-65
28794655-11	2017	Subsequently, P2Y12 and P2Y13 receptor-evoked release of IL-1beta, IL-6 and TNF-alpha, were also inhibited by Y-27632, SB203580 and PDTC, respectively.	SB 203580	119-127	interleukin 1 beta	Homo sapiens	57-65
28744016-3	2017	Anti-inflammatory effects were assessed by Nitric Oxide (NO), Prostaglandin E2 (PGE2) and Metalloprotease (MMP) release in IL-1beta-stimulated chondrocytes.	Nitric Oxide	43-55	interleukin 1 beta	Homo sapiens	123-131
28744016-8	2017	By whole-transcriptome analysis, we identified that DNZep counteracts the effect of IL-1beta on the expression of 81 protein-coding genes, including CITED2, an MMP inhibitor.	dnzep	52-57	interleukin 1 beta	Homo sapiens	84-92
28636034-6	2017	However, zinc(ii)-protoporphyrin IX (ZnPPIX), a selective inhibitor of HO-1, restored the GHP-mediated suppression of ROS production and NOX2, TNF-alpha, IL-1beta, IL-6 and iNOS expression.	zinc(ii)-protoporphyrin ix	9-35	interleukin 1 beta	Homo sapiens	154-162
28636034-6	2017	However, zinc(ii)-protoporphyrin IX (ZnPPIX), a selective inhibitor of HO-1, restored the GHP-mediated suppression of ROS production and NOX2, TNF-alpha, IL-1beta, IL-6 and iNOS expression.	ghp	90-93	interleukin 1 beta	Homo sapiens	154-162
28732502-11	2017	The mechanistic studies revealed that chronic DEX exposure significantly increased the expression of NLRP1, ASC, caspase-1, IL-1beta, L-18, and BK protein and NLRP1, IL-1beta and BK mRNA levels in hippocampal neurons.	Dexamethasone	46-49	interleukin 1 beta	Homo sapiens	124-132
28732502-11	2017	The mechanistic studies revealed that chronic DEX exposure significantly increased the expression of NLRP1, ASC, caspase-1, IL-1beta, L-18, and BK protein and NLRP1, IL-1beta and BK mRNA levels in hippocampal neurons.	Dexamethasone	46-49	interleukin 1 beta	Homo sapiens	166-174
28775986-7	2017	Serotonin can also suppress the release of tumor necrosis factor-alpha and interleukin-1beta by activating serotonin receptors.	Serotonin	0-9	interleukin 1 beta	Homo sapiens	75-92
29798256-5	2017	The levels of IL-1beta, IL-8 and TNF-alpha in saliva were lower on the third day and fifth day (P&lt; 0.05).Conclusion:Applying Cetylpyridinium Chloride Buccal Tablets during perioperative period can effectively relieve postoperative pharyngeal pain and inflammatory response in patients with OSAHS.	cetylpyridinium chloride buccal	128-159	interleukin 1 beta	Homo sapiens	14-22
28636034-6	2017	However, zinc(ii)-protoporphyrin IX (ZnPPIX), a selective inhibitor of HO-1, restored the GHP-mediated suppression of ROS production and NOX2, TNF-alpha, IL-1beta, IL-6 and iNOS expression.	znppix	37-43	interleukin 1 beta	Homo sapiens	154-162
28501579-5	2017	Concomitantly, MAG-EPA also abolished LPS-induced inflammation in PBMCs by reducing IL-1beta, IL-6, and TNFalpha cytokines at protein and transcript levels.	1-eicosapentaenoylglycerol	15-22	interleukin 1 beta	Homo sapiens	84-92
27660015-5	2017	Monoclonal antibodies (mAb) of anti-human IL-1b and anti-human IL-10 were electroaddressed onto the gold WEs through functionalization with 4-carboxymethyl aryl diazonium (CMA).	10-carboxymethyl-9-acridanone	172-175	interleukin 1 beta	Homo sapiens	42-47
28736555-0	2017	beta-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1beta Production.	beta-Glucans	0-11	interleukin 1 beta	Homo sapiens	100-108
28736555-3	2017	We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans.	beta-Glucans	13-24	interleukin 1 beta	Homo sapiens	178-186
28736555-5	2017	Furthermore, we show that the capacity to induce phagocytosis, and the relative IL-1beta production determined by beta-glucan size, regulates the composition of the cytokine milieu generated from DC.	beta-Glucans	114-125	interleukin 1 beta	Homo sapiens	80-88
28736555-3	2017	We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans.	beta-Glucans	124-135	interleukin 1 beta	Homo sapiens	178-186
28683316-4	2017	Glutathionylation of the highly conserved Cys-188 in IL-1beta positively regulates its bioactivity by preventing its ROS-induced irreversible oxidation, including sulfinic acid and sulfonic acid formation.	Sulfonic Acids	181-194	interleukin 1 beta	Homo sapiens	53-61
30090537-5	2017	The mRNA levels of IL-6, IL-8, TNF-alpha and IL-1beta were upregulated by SiO2 NP or cold exposure, and more so in the combined group.	sio2 np	74-81	interleukin 1 beta	Homo sapiens	45-53
30090537-6	2017	The expressions of the proinflammatory cytokine genes IL-6, IL-8, TNF-alpha and IL-1beta increased highly significantly (P &lt; 0.01) in the SiO2 NP alone group and the combined group, compared with the control.	sio2 np	141-148	interleukin 1 beta	Homo sapiens	80-88
28683316-0	2017	Positive Regulation of Interleukin-1beta Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation.	Reactive Oxygen Species	70-73	interleukin 1 beta	Homo sapiens	23-40
28683316-5	2017	We show this mechanism protects IL-1beta from deactivation by ROS in an in vivo system of irradiation-induced bone marrow (BM) injury.	Reactive Oxygen Species	62-65	interleukin 1 beta	Homo sapiens	32-40
28683316-0	2017	Positive Regulation of Interleukin-1beta Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation.	Cysteine	83-91	interleukin 1 beta	Homo sapiens	23-40
28683316-4	2017	Glutathionylation of the highly conserved Cys-188 in IL-1beta positively regulates its bioactivity by preventing its ROS-induced irreversible oxidation, including sulfinic acid and sulfonic acid formation.	Cysteine	42-45	interleukin 1 beta	Homo sapiens	53-61
28725182-0	2017	Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1beta via Different Combinations of Nicotinic Acetylcholine Receptor Subunits alpha7, alpha9 and alpha10.	Adenosine Triphosphate	63-66	interleukin 1 beta	Homo sapiens	96-113
28683316-4	2017	Glutathionylation of the highly conserved Cys-188 in IL-1beta positively regulates its bioactivity by preventing its ROS-induced irreversible oxidation, including sulfinic acid and sulfonic acid formation.	Reactive Oxygen Species	117-120	interleukin 1 beta	Homo sapiens	53-61
28683316-4	2017	Glutathionylation of the highly conserved Cys-188 in IL-1beta positively regulates its bioactivity by preventing its ROS-induced irreversible oxidation, including sulfinic acid and sulfonic acid formation.	Sulfinic Acids	163-176	interleukin 1 beta	Homo sapiens	53-61
28725182-1	2017	Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1beta (IL-1beta) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of alpha7, alpha9 and/or alpha10 subunits.	Adenosine Triphosphate	66-88	interleukin 1 beta	Homo sapiens	116-133
28725182-1	2017	Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1beta (IL-1beta) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of alpha7, alpha9 and/or alpha10 subunits.	Adenosine Triphosphate	66-88	interleukin 1 beta	Homo sapiens	135-143
28725182-1	2017	Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1beta (IL-1beta) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of alpha7, alpha9 and/or alpha10 subunits.	Adenosine Triphosphate	90-93	interleukin 1 beta	Homo sapiens	116-133
28725182-1	2017	Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1beta (IL-1beta) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of alpha7, alpha9 and/or alpha10 subunits.	Adenosine Triphosphate	90-93	interleukin 1 beta	Homo sapiens	135-143
28725182-7	2017	Furthermore, we showed that LPC (C16:0) and G-PC efficiently inhibit ATP-dependent release of IL-1beta.	Adenosine Triphosphate	69-72	interleukin 1 beta	Homo sapiens	94-102
29744188-12	2017	Enhanced NLRP3 inflammasome-dependent secretion of IL-1beta and IL-18 in human mononuclear leukocytes exposed to NaHS in vitro is reported.	sodium bisulfide	113-117	interleukin 1 beta	Homo sapiens	51-59
28643288-6	2017	H2O2 treatment increased both the protein and mRNA levels of IL-1beta, IL-8, and TNF-alpha, as well as those of SAPK/JNK.	Hydrogen Peroxide	0-4	interleukin 1 beta	Homo sapiens	61-69
28643288-8	2017	In summary, the PAR2 antagonist peptide, FSLLRY-NH2, reduces the level of the pro-inflammatory genes IL-8, IL-1beta, and TNF-alpha induced by H2O2, through the SAPK/JNK pathways in HepG2 cells.	Hydrogen Peroxide	142-146	interleukin 1 beta	Homo sapiens	107-115
28458159-0	2017	Celastrol reduces IL-1beta induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo.	celastrol	0-9	interleukin 1 beta	Homo sapiens	18-26
28458159-3	2017	In this study, we evaluated the effect of celastrol on IDD in IL-1beta treated human nucleus pulposus cells in vitro as well as in puncture induced rat IDD model in vivo.	celastrol	42-51	interleukin 1 beta	Homo sapiens	62-70
28458159-6	2017	Together, our study demonstrates that celastrol could reduce IL-1beta induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo, which shows its potential to be a therapeutic drug for IDD.	celastrol	38-47	interleukin 1 beta	Homo sapiens	61-69
28740415-7	2017	Interestingly, our experiments show that the two fractions regulated cytokine secretion differently: ESM depressed inflammation by increased secretion of the anti-inflammatory cytokine IL-10 while the carbohydrate fraction reduced secretions of the pro inflammatory cytokines IL-1beta and IL-6.	Carbohydrates	201-213	interleukin 1 beta	Homo sapiens	276-284
29744188-0	2017	Hydrogen sulfide exposure induces NLRP3 inflammasome-dependent IL-1beta and IL-18 secretion in human mononuclear leukocytes in vitro.	Hydrogen Sulfide	0-16	interleukin 1 beta	Homo sapiens	63-71
28169456-3	2017	The protective effect of non-toxic concentrations of DADS on experimentally induced oxidative stress and apoptosis by IL-1beta in C28I2 was evaluated.	amsonic acid	53-57	interleukin 1 beta	Homo sapiens	118-126
29744188-1	2017	The aim was to investigate if hydrogen sulfide (H2S) induces the formation of the NLRP3 inflammasome and subsequent IL-1beta and IL-18 secretion in human peripheral blood mononuclear cells (PBMCs) and in the human monocyte cell line THP1.	Hydrogen Sulfide	30-46	interleukin 1 beta	Homo sapiens	116-124
29744188-1	2017	The aim was to investigate if hydrogen sulfide (H2S) induces the formation of the NLRP3 inflammasome and subsequent IL-1beta and IL-18 secretion in human peripheral blood mononuclear cells (PBMCs) and in the human monocyte cell line THP1.	Hydrogen Sulfide	48-51	interleukin 1 beta	Homo sapiens	116-124
28482330-4	2017	RESULTS: Dienogest markedly inhibited interleukin 1beta-stimulated C-C motif chemokine ligand 20 mRNA expression and protein secretion in EMosis-CC/TERT1/PRA-/PRB+, which was abrogated by the progesterone receptor antagonist RU486.	Mifepristone	225-230	interleukin 1 beta	Homo sapiens	38-55
28501006-0	2017	Liquid chromatography-mass spectrometry-based quantitative proteomics analysis reveals chondroprotective effects of astragaloside IV in interleukin-1beta-induced SW1353 chondrocyte-like cells.	astragaloside A	116-132	interleukin 1 beta	Homo sapiens	136-153
28534957-6	2017	Pretreatment with GSP before LPS treatment significantly suppressed the mRNA expression of pro-inflammatory cytokines such as IL-1beta, IL-6 and IL-8.	Grape Seed Proanthocyanidins	18-21	interleukin 1 beta	Homo sapiens	126-134
28534082-0	2017	Conformational dynamics and alignment properties of loop lanthanide-binding-tags (LBTs) studied in interleukin-1beta.	Lanthanoid Series Elements	57-67	interleukin 1 beta	Homo sapiens	99-116
28534082-4	2017	Here, we investigate the differences in fast dynamics of selected loop-LBT interleukin-1beta constructs by measuring 15N nuclear spin relaxation experiments.	15n	117-120	interleukin 1 beta	Homo sapiens	75-92
28169456-7	2017	DADS could considerably reduce IL-1beta-induced oxidative stress and consequent mitochondrial apoptosis, as the major mechanisms of chondrocyte cell death in an experimental model of osteoarthritis.	amsonic acid	0-4	interleukin 1 beta	Homo sapiens	31-39
28169456-4	2017	The effects of DADS on IL-1beta-induced intracellular ROS production and lipid peroxidation were detected and the proteins expression of Nrf2, Bax, Bcl-2, caspase-3, total and phosphorylated JNK, and P38 MAPKs were analyzed by Western blotting.	amsonic acid	15-19	interleukin 1 beta	Homo sapiens	23-31
28169456-4	2017	The effects of DADS on IL-1beta-induced intracellular ROS production and lipid peroxidation were detected and the proteins expression of Nrf2, Bax, Bcl-2, caspase-3, total and phosphorylated JNK, and P38 MAPKs were analyzed by Western blotting.	ros	54-57	interleukin 1 beta	Homo sapiens	23-31
28169456-6	2017	DADS in 1, 5, 10, and 25 muM concentrations had no cytotoxic effect after 24 h. Pretreatment with DADS remarkably increased Nrf2 nuclear translocation as well as the genes expression of detoxifying phase II/antioxidant enzymes and reduced IL-1beta-induced elevation of ROS, lipid peroxidation, Bax/Bcl-2 ratio, caspase-3 activation, and JNK and P38 phosphorylation.	amsonic acid	98-102	interleukin 1 beta	Homo sapiens	239-247
28377398-8	2017	Furthermore, we determined that IL-27 primes cells for enhanced IL-1beta production by up-regulating surface expression of TLR4 and P2X purinoceptor 7 (P2X7) for enhanced LPS and ATP signaling, respectively.	Adenosine Triphosphate	179-182	interleukin 1 beta	Homo sapiens	64-72
28377398-9	2017	These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta secretion levels triggered by dual LPS-ATP stimulation.	Adenosine Triphosphate	194-197	interleukin 1 beta	Homo sapiens	146-154
28667247-10	2017	Compared with the other groups, the combination of Astragaloside and Baicalin more efficiently reduced IL-1beta, IL-8, and TNF-alpha levels in the LPS-induced MSCs model, and ERK inhibitor was capable of recovering the inflammatory effect.	astragaloside	51-64	interleukin 1 beta	Homo sapiens	103-111
28116487-7	2017	Serum IL-1beta levels were significantly associated with the magnitude of vasoconstriction to acetylcholine at the segment distal (P &lt; 0.05) but not proximal to the stent.	Acetylcholine	94-107	interleukin 1 beta	Homo sapiens	6-14
28116487-10	2017	Sirolimus directly increased IL-1beta mRNA expression (P &lt; 0.01) and enhanced IL-1beta release into the culture media (P &lt; 0.01) in CASMCs, but not in HUVECs.	Sirolimus	0-9	interleukin 1 beta	Homo sapiens	29-37
28116487-10	2017	Sirolimus directly increased IL-1beta mRNA expression (P &lt; 0.01) and enhanced IL-1beta release into the culture media (P &lt; 0.01) in CASMCs, but not in HUVECs.	Sirolimus	0-9	interleukin 1 beta	Homo sapiens	81-89
28501737-0	2017	The BCR/ABL tyrosine kinase inhibitor, nilotinib, stimulates expression of IL-1beta in vascular endothelium in association with downregulation of miR-3p.	nilotinib	39-48	interleukin 1 beta	Homo sapiens	75-83
28501737-5	2017	Nilotinib-induced IL-1beta expression stimulated the adhesion of monocytes to vascular endothelial cells in association with an increase in levels of adhesion molecules.	nilotinib	0-9	interleukin 1 beta	Homo sapiens	18-26
28501737-8	2017	Importantly, forced-expression of miR-3121-3p counteracted nilotinib-induced expression of IL-1beta.	nilotinib	59-68	interleukin 1 beta	Homo sapiens	91-99
28501737-9	2017	Importantly, serum levels if IL-1beta were significantly elevated in CML patients receiving nilotinib (n=14) compared to those receiving other TKIs (n=16) (3.76+-1.22pg/ml vs 0.27+-0.77pg/ml, p&lt;0.05).	nilotinib	92-101	interleukin 1 beta	Homo sapiens	29-37
28501737-10	2017	Taken together, our data suggest that nilotinib decreases levels of miR-3121-3p resulting in an increase in expression of IL-1beta and adhesion molecules in vascular endothelial cells.	nilotinib	38-47	interleukin 1 beta	Homo sapiens	122-130
28667247-10	2017	Compared with the other groups, the combination of Astragaloside and Baicalin more efficiently reduced IL-1beta, IL-8, and TNF-alpha levels in the LPS-induced MSCs model, and ERK inhibitor was capable of recovering the inflammatory effect.	baicalin	69-77	interleukin 1 beta	Homo sapiens	103-111
28693192-3	2017	The results demonstrated that QNZ and regorafenib significantly reduced the expression and secretion levels of the angiogenesis- and metastasis-associated proteins vascular endothelial growth factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, matrix metalloproteinase (MMP)-2 and MMP-9, NF-kappaB activation and cell invasion.	EVP 4593	30-33	interleukin 1 beta	Homo sapiens	229-251
28283331-2	2017	The present study aimed to investigate the effect of forkhead transcription factor O1 (FoxO1) expression on interleukin-1beta (IL-1beta)-induced autostimulation, both in vitro in human retina microvascular endothelial cells (HRMECs), and in vivo in retinas isolated from streptozotocin-induced diabetic rats.	Streptozocin	271-285	interleukin 1 beta	Homo sapiens	108-125
28283331-2	2017	The present study aimed to investigate the effect of forkhead transcription factor O1 (FoxO1) expression on interleukin-1beta (IL-1beta)-induced autostimulation, both in vitro in human retina microvascular endothelial cells (HRMECs), and in vivo in retinas isolated from streptozotocin-induced diabetic rats.	Streptozocin	271-285	interleukin 1 beta	Homo sapiens	127-135
28356331-9	2017	Quiescent human prostate stroma exposed to genotoxic agents (e.g., mitoxantrone) in vivo resulted in significant upregulation (2.7- to 5.7-fold; P &lt;= 0.01) of growth factors and cytokines including IL1beta, MMP3, IL6, and IL8.	Mitoxantrone	67-79	interleukin 1 beta	Homo sapiens	201-208
28693192-3	2017	The results demonstrated that QNZ and regorafenib significantly reduced the expression and secretion levels of the angiogenesis- and metastasis-associated proteins vascular endothelial growth factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, matrix metalloproteinase (MMP)-2 and MMP-9, NF-kappaB activation and cell invasion.	regorafenib	38-49	interleukin 1 beta	Homo sapiens	229-251
28797636-3	2017	The aim of the study was to examine the influence of inositol hexaphosphate (IP6), a naturally occurring phytochemical, on the expression of genes encoding COX and LOX isoforms and synthesis of their products (PGE2 and LTB4) in colon cancer cell line Caco-2 stimulated with pro-inflammatory agents (IL-1beta/TNFalpha).	Phytic Acid	53-75	interleukin 1 beta	Homo sapiens	299-307
28839362-7	2017	The methanol extracts of seeds also demonstrated the highest inhibition of TNF-alpha, IL-1beta, IL-6, and IFN-gamma production.	Methanol	4-12	interleukin 1 beta	Homo sapiens	86-94
28797636-3	2017	The aim of the study was to examine the influence of inositol hexaphosphate (IP6), a naturally occurring phytochemical, on the expression of genes encoding COX and LOX isoforms and synthesis of their products (PGE2 and LTB4) in colon cancer cell line Caco-2 stimulated with pro-inflammatory agents (IL-1beta/TNFalpha).	Phytic Acid	77-80	interleukin 1 beta	Homo sapiens	299-307
28444390-10	2017	SMX-NO/flucloxacillin stimulated secretion of TNF-alpha, IL-6, IL-1alpha, and IL-1-beta.	4-nitrososulfamethoxazole	0-6	interleukin 1 beta	Homo sapiens	78-87
30970932-6	2017	The results indicated that compared to oxygen plasma, nitrogen plasma treatment produced an anti-inflammatory effect on the collagen film by reducing the initial activation of monocytes and macrophages, which led to a lower production of pro-inflammatory cytokines IL-1beta and TNFalpha, and higher production of anti-inflammatory cytokine IL-10.	Nitrogen	54-62	interleukin 1 beta	Homo sapiens	265-273
28444390-10	2017	SMX-NO/flucloxacillin stimulated secretion of TNF-alpha, IL-6, IL-1alpha, and IL-1-beta.	Floxacillin	7-21	interleukin 1 beta	Homo sapiens	78-87
28665310-7	2017	The ArtinM effect on aberrantly-glycosylated neoplastic lymphocytes was studied in Jurkat T cells, in which ArtinM induced IL-2, IFN-gamma, and IL-1beta production, but decreased cell viability and growth.	artinm	108-114	interleukin 1 beta	Homo sapiens	144-152
28665978-9	2017	Our results demonstrated testosterone not only suppressed the invasion and colonization of UPEC, but also inhibited the expression of pro-inflammatory IL-1beta, IL-6 and IL-8 cytokines expression induced by UPEC in a dose-dependent manner.	Testosterone	25-37	interleukin 1 beta	Homo sapiens	151-159
28442557-5	2017	Incubation of cells in an HP (3.3 mM) medium caused an increased expression of the pro-inflammatory mediators intercellular adhesion molecule 1 (ICAM-1), interleukins (ILs) IL-1beta, IL-6, IL-8 and tumour necrosis factor alpha (TNF-alpha) (not corroborated at the protein levels for ICAM-1), as well as an increase in reactive oxygen/nitrogen species (ROS/RNS) production.	Hematoporphyrins	26-28	interleukin 1 beta	Homo sapiens	173-181
28530644-6	2017	Subsequent increases in IL-1beta expression and secretion contributed to hepatocyte damage and promoted development of ethanol-induced liver disease.	Ethanol	119-126	interleukin 1 beta	Homo sapiens	24-32
28978034-3	2017	Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibits subsequent caspase-1 activation and IL-1beta secretion both in vitro and in vivo.	celastrol	19-28	interleukin 1 beta	Homo sapiens	119-127
28659178-2	2017	Azithromycin inhibits IL-1beta-mediated inflammation that is dependent, in part, on inflammasome activity.	Azithromycin	0-12	interleukin 1 beta	Homo sapiens	22-30
28659178-10	2017	RESULTS: Azithromycin decreased IL-1beta levels and reduced NALP3 protein levels in LPS-stimulated THP-1 monocytes through a mechanism involving decreased mRNA stability of the NALP3 - coding NLRP3 gene transcript as well as by decreasing NF-kappaB activity.	Azithromycin	9-21	interleukin 1 beta	Homo sapiens	32-40
28659178-12	2017	CONCLUSIONS: These studies provide a unique mechanism whereby azithromycin exerts immunomodulatory actions in monocytes by destabilizing mRNA levels for a key inflammasome component, NALP3, leading to decreased IL-1beta-mediated inflammation.	Azithromycin	62-74	interleukin 1 beta	Homo sapiens	211-219
28507161-5	2017	We conclude that IL-1beta can induce the activation of TAK1 in two ways, only one of which requires the binding of K63-Ub chains to TAB2/3.	k63-ub	115-121	interleukin 1 beta	Homo sapiens	17-25
28645333-6	2017	Treatment with Sac-1004 significantly blocked the interleukin-1beta-induced monolayer hyperpermeability of human brain microvascular endothelial cells (HBMECs), loss of tight junctions, and formation of actin stress fiber.	CU06-1004	15-23	interleukin 1 beta	Homo sapiens	50-67
28645296-0	2017	MyD88-dependent pro-interleukin-1beta induction in dendritic cells exposed to food-grade synthetic amorphous silica.	Silicon Dioxide	109-115	interleukin 1 beta	Homo sapiens	16-37
28646230-8	2017	Functionally, asporin was the intermediator of IL-1beta-inhibited aggrecan and collagen Pi expression and played a negative role in TGF-beta-induced aggrecan and collagen Pi formation in human nucleus pulposus cells.	asporin	14-21	interleukin 1 beta	Homo sapiens	47-55
28645296-7	2017	Also, the endocytic uptake of SAS particles into these steady-state DCs leads to induction of the pro-IL-1beta precursor, subsequently cleaved by the inflammasome to secrete mature IL-1beta.	sas	30-33	interleukin 1 beta	Homo sapiens	98-110
28645296-7	2017	Also, the endocytic uptake of SAS particles into these steady-state DCs leads to induction of the pro-IL-1beta precursor, subsequently cleaved by the inflammasome to secrete mature IL-1beta.	sas	30-33	interleukin 1 beta	Homo sapiens	102-110
28645296-11	2017	The ensuing activation of immature DCs with de novo induction of pro-IL-1beta implies that the currently massive use of SAS particles as food additive should be reconsidered.	sas	120-123	interleukin 1 beta	Homo sapiens	65-77
29228585-11	2017	The supernatant concentrations of IL-1beta in the DV and T2DM groups were higher than those in the control group, and treatment with AG490 decreased the IL-1beta concentration.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	133-138	interleukin 1 beta	Homo sapiens	153-161
28489580-3	2017	Here we demonstrate that autophagy induction by rapamycin suppressed the production of IL-1beta and IL-18 in lipopolysaccharide- and adenosine triphosphate-activated macrophages at the post-transcriptional level by eliminating mitochondrial ROS (mtROS) and pro-IL1beta in a p62/SQSTM1-dependent manner.	Adenosine Triphosphate	133-155	interleukin 1 beta	Homo sapiens	87-95
28489580-3	2017	Here we demonstrate that autophagy induction by rapamycin suppressed the production of IL-1beta and IL-18 in lipopolysaccharide- and adenosine triphosphate-activated macrophages at the post-transcriptional level by eliminating mitochondrial ROS (mtROS) and pro-IL1beta in a p62/SQSTM1-dependent manner.	Adenosine Triphosphate	133-155	interleukin 1 beta	Homo sapiens	257-268
28489580-3	2017	Here we demonstrate that autophagy induction by rapamycin suppressed the production of IL-1beta and IL-18 in lipopolysaccharide- and adenosine triphosphate-activated macrophages at the post-transcriptional level by eliminating mitochondrial ROS (mtROS) and pro-IL1beta in a p62/SQSTM1-dependent manner.	ros	241-244	interleukin 1 beta	Homo sapiens	87-95
28592027-5	2017	Results: Compared with the control group, the protein expressions of NLRP3, caspase-1 and IL-1beta in PASMCs were increased to (1.38+-0.09, t=3.998, P&lt;0.001), (1.32+-0.1, t=3.268, P&lt;0.01)and(1.43+-0.19) (t=2.096, P&lt;0.05) folds in the PDGF group.	pasmcs	102-108	interleukin 1 beta	Homo sapiens	90-98
28591158-4	2017	Enzymatic activities of citrate synthase and mitochondrial complexes I, IV, and ATP synthase and ATP content of monocytes, T-cells and B-cells and pro-inflammatory (IL-1beta and IL-6) and anti-inflammatory (IL-10) cytokine plasma concentrations were compared to samples from 20 healthy volunteers.	Adenosine Triphosphate	80-83	interleukin 1 beta	Homo sapiens	165-173
28476620-8	2017	We found that the high level of Gm4419 promoted the phosphorylation of IkappaBalpha by physically associating with IkappaBalpha, therefore, led to increased nucleus NF-kappaB levels for the transcriptional activation of TNF-alpha, IL-1beta and IL-6.	gm4419	32-38	interleukin 1 beta	Homo sapiens	231-239
28499612-6	2017	Pro inflammatory cytokines, IL1beta and TNFalpha were more expressed in arsenic-treated MDDCs while IL6 transiently was down regulated.	Arsenic	72-79	interleukin 1 beta	Homo sapiens	28-35
28402673-12	2017	In conclusion, ACL enhances the therapeutic and anticancer efficacy of MTX, when coencapsulated into fucose-anchored LPHNPs, as confirmed by cell viability and serum angiogenesis (IL-6, TNF-alpha, IL-1beta, COX2, and MMP1) at both transcript and proteome level.	Methotrexate	71-74	interleukin 1 beta	Homo sapiens	197-205
28402673-12	2017	In conclusion, ACL enhances the therapeutic and anticancer efficacy of MTX, when coencapsulated into fucose-anchored LPHNPs, as confirmed by cell viability and serum angiogenesis (IL-6, TNF-alpha, IL-1beta, COX2, and MMP1) at both transcript and proteome level.	Fucose	101-107	interleukin 1 beta	Homo sapiens	197-205
28129516-16	2017	In serum and synovial fluid, both rhPRG4 ( P = .006; P = .017) and rhPRG4+hyaluronan groups ( P = .009; P = .03) presented decreased IL-1beta levels.	Hyaluronic Acid	74-84	interleukin 1 beta	Homo sapiens	133-141
28915567-11	2017	TNF-alpha, IL-1beta, PGE2, or NO decrease caused the similar reduction of MMP-3 and MMP-13 by melatonin in IL-1beta-insulted chondrocytes.	Melatonin	94-103	interleukin 1 beta	Homo sapiens	107-115
28915567-13	2017	Overall, these results indicate that melatonin effectively reduced IL-1beta-induced MMP production by inhibiting Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes, suggesting melatonin as a potential therapeutic alternative for chondroprotection of OA patients.	Melatonin	37-46	interleukin 1 beta	Homo sapiens	67-75
28915567-13	2017	Overall, these results indicate that melatonin effectively reduced IL-1beta-induced MMP production by inhibiting Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes, suggesting melatonin as a potential therapeutic alternative for chondroprotection of OA patients.	Melatonin	183-192	interleukin 1 beta	Homo sapiens	67-75
28915567-5	2017	In this study, we found that melatonin inhibited IL-1beta-induced toxicity and sirtuin 1 (Sirt1) enhancement in human chondrocytes.	Melatonin	29-38	interleukin 1 beta	Homo sapiens	49-57
28915567-6	2017	Melatonin reduced the IL-1beta-increased nicotinamide phosphoribosyltransferase (NAMPT) expression and the NAD+ level in chondrocytes in a Sirt1-dependent manner.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	22-30
28915567-6	2017	Melatonin reduced the IL-1beta-increased nicotinamide phosphoribosyltransferase (NAMPT) expression and the NAD+ level in chondrocytes in a Sirt1-dependent manner.	NAD	107-111	interleukin 1 beta	Homo sapiens	22-30
28915567-8	2017	Moreover, melatonin suppressed IL-1beta-induced Sirt1-mediated matrix metalloproteinase (MMP)-3 and MMP-13 production.	Melatonin	10-19	interleukin 1 beta	Homo sapiens	31-39
28915567-9	2017	Melatonin also decreased the Sirt1-steered nuclear factor of activated T cells 5 (NFAT5) expression in IL-1beta-challenged chondrocytes.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	103-111
28915567-10	2017	NFAT5 depletion mimicked the suppressive effects of melatonin on IL-1beta-elevated production of inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), IL-1beta, prostaglandin E2 (PGE2), and nitric oxide (NO) in chondrocytes.	Melatonin	52-61	interleukin 1 beta	Homo sapiens	65-73
28915567-10	2017	NFAT5 depletion mimicked the suppressive effects of melatonin on IL-1beta-elevated production of inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), IL-1beta, prostaglandin E2 (PGE2), and nitric oxide (NO) in chondrocytes.	Dinoprostone	200-204	interleukin 1 beta	Homo sapiens	65-73
28915567-10	2017	NFAT5 depletion mimicked the suppressive effects of melatonin on IL-1beta-elevated production of inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), IL-1beta, prostaglandin E2 (PGE2), and nitric oxide (NO) in chondrocytes.	Nitric Oxide	211-223	interleukin 1 beta	Homo sapiens	65-73
28915567-11	2017	TNF-alpha, IL-1beta, PGE2, or NO decrease caused the similar reduction of MMP-3 and MMP-13 by melatonin in IL-1beta-insulted chondrocytes.	Melatonin	94-103	interleukin 1 beta	Homo sapiens	11-19
28389361-4	2017	ANXA1 was found to have a promoting effect on the expression of IL-1beta in primary cultured RGCs, which could be inhibited by treatment with ANXA1 shRNA or the p65 inhibitor BAY 11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	175-186	interleukin 1 beta	Homo sapiens	64-72
28528204-5	2017	Remarkably, aspirin strongly reduced the pro-inflammatory IL-1beta and TNF-alpha production, while it increased the anti-inflammatory IL-10 level in LPS-challenged cells.	Aspirin	12-19	interleukin 1 beta	Homo sapiens	58-66
28528204-6	2017	Moreover, aspirin differentially regulated the expression of a number of inflammation-related genes as it downregulated such pro-inflammatory genes as Nos2, Kng1, IL1beta, Ptgs2 or Ccr1, while it upregulated some anti-inflammatory genes such as IL10, Csf2, Cxcl1, Ccl5 or Tgfb1.	Aspirin	10-17	interleukin 1 beta	Homo sapiens	163-170
28326454-7	2017	Increased production of ROS and expression of IL-1beta, IL-18, and caspase-1 genes and proteins were observed in U937 and THP-1 cells incubated with fructose and were effectively inhibited by quercetin and ascorbic acid.	Fructose	149-157	interleukin 1 beta	Homo sapiens	46-54
28238855-13	2017	These findings demonstrate a regulatory function for MKP-1 in modulating IL-1beta expression through p38 activation, ROS production and HIF-1alpha expression.	Reactive Oxygen Species	117-120	interleukin 1 beta	Homo sapiens	73-81
28195341-7	2017	The decrease in EIVPD induced by phenylephrine was inversely related to baseline systolic function (P &lt; 0.05) and associated with markers of systemic vasodilatation (nitric oxide, rho = -0.66, P = 0.06; diastolic blood pressure, rho = 0.68, P = 0.04) and inflammation (interleukin-1beta, rho = -0.80, P = 0.009).	Phenylephrine	33-46	interleukin 1 beta	Homo sapiens	272-289
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	6-Hydroxyrubiadin	33-50	interleukin 1 beta	Homo sapiens	114-136
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	149-174	interleukin 1 beta	Homo sapiens	114-136
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	176-179	interleukin 1 beta	Homo sapiens	114-136
28337636-3	2017	Our results showed that EVO effectively suppressed both protein and mRNA expression of interleukin-1beta, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in vitro.	evodiamine	24-27	interleukin 1 beta	Homo sapiens	87-104
28168658-10	2017	We found that plumbagin significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-3, and MMP-13; and degradation of aggrecan and collagen-II.	Dinoprostone	90-94	interleukin 1 beta	Homo sapiens	52-60
28188410-0	2017	Simvastatin Inhibits IL-1beta-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	21-29
28188410-9	2017	Our findings indicate that simvastatin considerably inhibited IL-1beta-induced apoptosis in NP cells.	Simvastatin	27-38	interleukin 1 beta	Homo sapiens	62-70
28188410-10	2017	We also found that simvastatin attenuated IL-1beta-induced expression and MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5 activities and also reduced the decrease in type II collagen and aggrecan expression.	Simvastatin	19-30	interleukin 1 beta	Homo sapiens	42-50
27922186-0	2017	Characterization of the Pro-Inflammatory Cytokine IL-1beta on Butyrate Oxidation in Colorectal Cancer Cells.	Butyrates	62-70	interleukin 1 beta	Homo sapiens	50-58
27922186-7	2017	We hypothesize that IL-1beta will push cancerous colonocytes away from the utilization and oxidation of butyrate.	Butyrates	104-112	interleukin 1 beta	Homo sapiens	20-28
27922186-8	2017	In this study, we demonstrate that pretreatment of colorectal cancer cells with IL-1beta diminished butyrate oxidation and NADH levels.	Butyrates	100-108	interleukin 1 beta	Homo sapiens	80-88
27922186-8	2017	In this study, we demonstrate that pretreatment of colorectal cancer cells with IL-1beta diminished butyrate oxidation and NADH levels.	NAD	123-127	interleukin 1 beta	Homo sapiens	80-88
27922186-11	2017	By using inhibitors to block downstream targets of the interleukin-1 receptor pathway, we show that p38 is required for the IL-1beta-mediated decrease in butyrate oxidation.	Butyrates	154-162	interleukin 1 beta	Homo sapiens	124-132
28569730-5	2017	This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1beta to active IL-1beta and pyroptosis.	Uric Acid	125-134	interleukin 1 beta	Homo sapiens	201-213
28569730-5	2017	This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1beta to active IL-1beta and pyroptosis.	Uric Acid	125-134	interleukin 1 beta	Homo sapiens	205-213
28569730-5	2017	This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1beta to active IL-1beta and pyroptosis.	Adenosine Triphosphate	138-141	interleukin 1 beta	Homo sapiens	201-213
28569730-5	2017	This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1beta to active IL-1beta and pyroptosis.	Adenosine Triphosphate	138-141	interleukin 1 beta	Homo sapiens	205-213
28232386-5	2017	Our results show that IL-1beta production by LPS-stimulated M-macrophages is a rapid and short event that requires ATP supplementation and is attenuated, in part, by the presence of IL-10, which reduces Akt signaling.	Adenosine Triphosphate	115-118	interleukin 1 beta	Homo sapiens	22-30
28232386-8	2017	Furthermore, we provide evidence that adenosine treatment enhances LPS-primed IL-1beta secretion by GM-macrophages, but not by M-macrophages.	Adenosine	38-47	interleukin 1 beta	Homo sapiens	78-86
28404637-0	2017	Surfactant inhibits ATP-induced release of interleukin-1beta via nicotinic acetylcholine receptors.	Adenosine Triphosphate	20-23	interleukin 1 beta	Homo sapiens	43-60
28404637-3	2017	In response to various danger signals, the pro-form of IL-1beta is synthesized and stays in the cytoplasm unless a second signal, such as extracellular ATP, activates the inflammasome, which enables processing and release of mature IL-1beta.	Adenosine Triphosphate	152-155	interleukin 1 beta	Homo sapiens	55-63
28404637-4	2017	As pulmonary surfactant is known for its anti-inflammatory properties, we hypothesize that surfactant inhibits ATP-induced release of IL-1beta.	Adenosine Triphosphate	111-114	interleukin 1 beta	Homo sapiens	134-142
28404637-10	2017	In conclusion, the surfactant constituent, DPPC, efficiently inhibits ATP-induced inflammasome activation and maturation of IL-1beta in human monocytes by a mechanism involving nAChRs.	1,2-Dipalmitoylphosphatidylcholine	43-47	interleukin 1 beta	Homo sapiens	124-132
28404637-10	2017	In conclusion, the surfactant constituent, DPPC, efficiently inhibits ATP-induced inflammasome activation and maturation of IL-1beta in human monocytes by a mechanism involving nAChRs.	Adenosine Triphosphate	70-73	interleukin 1 beta	Homo sapiens	124-132
28404639-7	2017	When HepG2 cells were exposed to LDL cholesterol, they developed cholesterol crystals in LD membranes, which caused activation of THP1 cells (macrophages) grown in coculture; upregulation of TNF-alpha, NLRP3, and interleukin 1beta (IL1beta) mRNA; and secretion of IL-1beta.	Cholesterol	37-48	interleukin 1 beta	Homo sapiens	213-230
28404639-7	2017	When HepG2 cells were exposed to LDL cholesterol, they developed cholesterol crystals in LD membranes, which caused activation of THP1 cells (macrophages) grown in coculture; upregulation of TNF-alpha, NLRP3, and interleukin 1beta (IL1beta) mRNA; and secretion of IL-1beta.	Cholesterol	37-48	interleukin 1 beta	Homo sapiens	232-239
28404639-7	2017	When HepG2 cells were exposed to LDL cholesterol, they developed cholesterol crystals in LD membranes, which caused activation of THP1 cells (macrophages) grown in coculture; upregulation of TNF-alpha, NLRP3, and interleukin 1beta (IL1beta) mRNA; and secretion of IL-1beta.	Cholesterol	37-48	interleukin 1 beta	Homo sapiens	264-272
28404639-7	2017	When HepG2 cells were exposed to LDL cholesterol, they developed cholesterol crystals in LD membranes, which caused activation of THP1 cells (macrophages) grown in coculture; upregulation of TNF-alpha, NLRP3, and interleukin 1beta (IL1beta) mRNA; and secretion of IL-1beta.	Cholesterol	65-76	interleukin 1 beta	Homo sapiens	213-230
28404639-7	2017	When HepG2 cells were exposed to LDL cholesterol, they developed cholesterol crystals in LD membranes, which caused activation of THP1 cells (macrophages) grown in coculture; upregulation of TNF-alpha, NLRP3, and interleukin 1beta (IL1beta) mRNA; and secretion of IL-1beta.	Cholesterol	65-76	interleukin 1 beta	Homo sapiens	232-239
28404639-7	2017	When HepG2 cells were exposed to LDL cholesterol, they developed cholesterol crystals in LD membranes, which caused activation of THP1 cells (macrophages) grown in coculture; upregulation of TNF-alpha, NLRP3, and interleukin 1beta (IL1beta) mRNA; and secretion of IL-1beta.	Cholesterol	65-76	interleukin 1 beta	Homo sapiens	264-272
27726055-9	2017	Treatment with the caspase-1 inhibitor, VX-765, suppressed NLRP3 expression with reduced IL-1beta expression and associated neuroinflammation.	belnacasan	40-46	interleukin 1 beta	Homo sapiens	89-97
28433363-4	2017	We sought to determine the effect of Omegaven , EPA, and DHA on inflammatory cytokines TNF-alpha, IL-1, and TGF-beta via ERK1/2 and p-Smad2/3 signaling pathways as well as the changes in intracellular PON1 protein expression as a potential mechanism explaining the protective effects of Omegaven  and Omega3FA.	Docosahexaenoic Acids	57-60	interleukin 1 beta	Homo sapiens	98-102
28408139-7	2017	Both mRNA and protein expression levels of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta), IL-6 and, tumor necrosis factor-alpha (TNF-alpha) which were increased after induction with H2O2, could be attenuated by melatonin.	Hydrogen Peroxide	197-201	interleukin 1 beta	Homo sapiens	75-92
28408139-7	2017	Both mRNA and protein expression levels of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta), IL-6 and, tumor necrosis factor-alpha (TNF-alpha) which were increased after induction with H2O2, could be attenuated by melatonin.	Hydrogen Peroxide	197-201	interleukin 1 beta	Homo sapiens	94-102
28408139-7	2017	Both mRNA and protein expression levels of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta), IL-6 and, tumor necrosis factor-alpha (TNF-alpha) which were increased after induction with H2O2, could be attenuated by melatonin.	Melatonin	226-235	interleukin 1 beta	Homo sapiens	75-92
28475276-12	2017	Initiation of MTX was associated with reductions in IL-1alpha (p=0.009), IL-1beta (p=0.01), IL-1Ra (p=0.007), and IL-6 (p=0.03) levels; however, reductions in JADAS were only associated with reductions in IL-6 (p=0.009) and TNF-alpha levels (p=0.02).	Methotrexate	14-17	interleukin 1 beta	Homo sapiens	73-81
29442025-4	2017	However, the molecular mechanism underlying the effect of sinominine on IL-1beta-induced human RA fibroblast-like synoviocytes (RAFLS) is poorly understood.	sinominine	58-68	interleukin 1 beta	Homo sapiens	72-80
29442025-5	2017	Therefore, in this study, we investigated the effect of sinomenine on the expression of inflammatory cytokines in IL-1beta-treated human RAFLS in vitro and the underlying mechanism.	sinomenine	56-66	interleukin 1 beta	Homo sapiens	114-122
29442025-9	2017	We found that sinomenine suppressed not only NO and PGE2 production but also iNOS and COX-2 expression in IL-1beta-induced RAFLS.	sinomenine	14-24	interleukin 1 beta	Homo sapiens	106-114
29442025-11	2017	Furthermore, sinomenine prevented IL-1beta-induced TLR4, MyD88 and p-NF-kappaB p65 expression.	sinomenine	13-23	interleukin 1 beta	Homo sapiens	34-42
29442025-12	2017	Taken together, these results demonstrated that sinomenine prevented IL-1beta-induced inflammation in human RAFLS at least in part by inhibiting the TLR4/MyD88/NF-kappaB signaling pathway, suggesting that sinomenine could be a potential agent in the treatment of RA.	sinomenine	48-58	interleukin 1 beta	Homo sapiens	69-77
29442025-12	2017	Taken together, these results demonstrated that sinomenine prevented IL-1beta-induced inflammation in human RAFLS at least in part by inhibiting the TLR4/MyD88/NF-kappaB signaling pathway, suggesting that sinomenine could be a potential agent in the treatment of RA.	sinomenine	205-215	interleukin 1 beta	Homo sapiens	69-77
28570653-6	2017	RESULTS: AIT combined with short-term TOFA administration was significantly more effective in suppressing total cell and eosinophil infiltration into the lung, local cytokine production including IL-1beta and CXCL1 and showed a trend for the reduction of IL-4, IL-13, TNF-alpha and IL-6 compared to AIT alone.	tofacitinib	38-42	interleukin 1 beta	Homo sapiens	196-204
28570653-7	2017	Furthermore, TOFA co-administration significantly reduced systemic IL-6, IL-1beta and OVA-specific IgE levels and induced IgG1 to the same extent as AIT alone.	tofacitinib	13-17	interleukin 1 beta	Homo sapiens	73-81
27133964-6	2017	In cells transfected with OPTN siRNA, significant increases were seen in IL1B-stimulated IL6, tumour necrosis factor, CXCL8 and monocyte chemoattractant protein-1 mRNA expression and release, cyclo-oxygenase-2 and prostanoid PTGFR receptor mRNA expression and the release of prostaglandin F2alpha.	Dinoprost	275-296	interleukin 1 beta	Homo sapiens	73-77
28285151-0	2017	Aryl hydrocarbon receptor upregulates IL-1beta expression in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure.	Polychlorinated Dibenzodioxins	123-127	interleukin 1 beta	Homo sapiens	38-46
28285151-5	2017	Exposure to TCDD increased IL-1beta mRNA expression levels in hCMEC/D3.	Polychlorinated Dibenzodioxins	12-16	interleukin 1 beta	Homo sapiens	27-35
28285151-6	2017	By using small interfering RNA against AhR we demonstrated that TCDD effects on IL-1beta expression were mediated through AhR activation.	Polychlorinated Dibenzodioxins	64-68	interleukin 1 beta	Homo sapiens	80-88
28569157-0	2017	Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes.	sesamin	11-18	interleukin 1 beta	Homo sapiens	76-93
28569157-0	2017	Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes.	Chondroitin Sulfates	22-41	interleukin 1 beta	Homo sapiens	76-93
28569157-8	2017	The level of release and matrix accumulation of GAGs in IL-1beta pre-treated HAC pellets in the presence of sesamin was recovered.	Glycosaminoglycans	48-52	interleukin 1 beta	Homo sapiens	56-64
28569157-8	2017	The level of release and matrix accumulation of GAGs in IL-1beta pre-treated HAC pellets in the presence of sesamin was recovered.	hac	77-80	interleukin 1 beta	Homo sapiens	56-64
28569157-8	2017	The level of release and matrix accumulation of GAGs in IL-1beta pre-treated HAC pellets in the presence of sesamin was recovered.	sesamin	108-115	interleukin 1 beta	Homo sapiens	56-64
28569157-10	2017	CONCLUSIONS: Sesamin enhances CSPGs synthesis, suppresses IL-1beta expression and ameliorates IL-1beta induced inflammation in human chondrocytes.	sesamin	13-20	interleukin 1 beta	Homo sapiens	58-66
28569157-10	2017	CONCLUSIONS: Sesamin enhances CSPGs synthesis, suppresses IL-1beta expression and ameliorates IL-1beta induced inflammation in human chondrocytes.	sesamin	13-20	interleukin 1 beta	Homo sapiens	94-102
28484006-3	2017	In this study, we investigated the mechanisms through which uric acid selectively lowers human blood monocyte production of the natural inhibitor IL-1 receptor antagonist (IL-1Ra) and shifts production toward the highly inflammatory IL-1beta.	Uric Acid	60-69	interleukin 1 beta	Homo sapiens	233-241
28588495-1	2017	The history of what, in 1979, was called interleukin-1 (IL-1), orchestrator of leukocyte inter-communication, began many years before then, initially by the observation of fever induction via the endogenous pyrogen (EP) (1974) and then in rheumatology on the role in tissue destruction in rheumatoid diseases via the induction of collagenase and PGE2 in human synovial cells by a mononuclear cell factor (MCF) (1977).	Dinoprostone	346-350	interleukin 1 beta	Homo sapiens	56-60
28326454-7	2017	Increased production of ROS and expression of IL-1beta, IL-18, and caspase-1 genes and proteins were observed in U937 and THP-1 cells incubated with fructose and were effectively inhibited by quercetin and ascorbic acid.	Quercetin	192-201	interleukin 1 beta	Homo sapiens	46-54
28326454-7	2017	Increased production of ROS and expression of IL-1beta, IL-18, and caspase-1 genes and proteins were observed in U937 and THP-1 cells incubated with fructose and were effectively inhibited by quercetin and ascorbic acid.	Ascorbic Acid	206-219	interleukin 1 beta	Homo sapiens	46-54
28507328-7	2017	ATP-induced IL-1beta secretion was controlled by the KCa1.1 inhibitor iberiotoxin.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	12-20
28402274-3	2017	Meantime, GM attenuated serum and HepG2 cell supernatant levels of TNF-alpha, IL-6, IL-1beta, SOD and MDA.	gm	10-12	interleukin 1 beta	Homo sapiens	84-92
28507328-7	2017	ATP-induced IL-1beta secretion was controlled by the KCa1.1 inhibitor iberiotoxin.	iberiotoxin	70-81	interleukin 1 beta	Homo sapiens	12-20
28507328-10	2017	In vitro, HCQ inhibited IL-1beta and caspase 1 activation induced by ATP in a dose-dependent manner.	Hydroxychloroquine	10-13	interleukin 1 beta	Homo sapiens	24-32
28507328-10	2017	In vitro, HCQ inhibited IL-1beta and caspase 1 activation induced by ATP in a dose-dependent manner.	Adenosine Triphosphate	69-72	interleukin 1 beta	Homo sapiens	24-32
28500309-5	2017	Resveratrol reduced sFlt-1, sFlt-1 e15a and soluble endoglin secretion from primary trophoblasts and HUVECs and reduced mRNA expression of pro-inflammatory molecules NFkappaB, IL-6 and IL-1beta in trophoblasts.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	185-193
28463985-0	2017	Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1beta.	Palmitic Acid	0-13	interleukin 1 beta	Homo sapiens	94-102
28536528-9	2017	MSC aggregate cultures which were maintained in chondrogenic media without IL1beta supplementation revealed a chondrogenic phenotype by means of strong positive staining for collagen type II and matrix proteoglycan (Alcian blue).	Alcian Blue	216-227	interleukin 1 beta	Homo sapiens	75-82
28342868-3	2017	We detected higher levels of interleukin (IL)-1beta and basic fibroblast growth factor (bFGF) in the cerebrospinal fluid (CFS) of patients with HHV-6B encephalitis when compared to those in patients with non-HHV-6B-induced febrile seizures.	6B	148-150	interleukin 1 beta	Homo sapiens	29-51
26983397-7	2017	These findings reveal a general mode of action of TRIMs as autophagic receptor-regulators performing a highly-selective type of autophagy (precision autophagy), with MEFV specializing in the suppression of inflammasome and CASP1 activation engendering IL1B/interleukin-1beta production and implicated in the form of cell death termed pyroptosis, whereas TRIM21 dampens type I interferon responses.	vinyl ethyl methacrylate	50-55	interleukin 1 beta	Homo sapiens	252-256
26983397-7	2017	These findings reveal a general mode of action of TRIMs as autophagic receptor-regulators performing a highly-selective type of autophagy (precision autophagy), with MEFV specializing in the suppression of inflammasome and CASP1 activation engendering IL1B/interleukin-1beta production and implicated in the form of cell death termed pyroptosis, whereas TRIM21 dampens type I interferon responses.	vinyl ethyl methacrylate	50-55	interleukin 1 beta	Homo sapiens	257-274
28463985-8	2017	Further experiments showed that PA induced TLR4 dependent secretion of the pro-inflammatory cytokine IL-1beta.	Palmitic Acid	32-34	interleukin 1 beta	Homo sapiens	101-109
27903507-7	2017	RESULTS: HCQ strongly reduces or completely prevents the induction of endosomal NOX by TNFalpha, IL-1beta and aPL in human monocytes and MonoMac1 cells.	Hydroxychloroquine	9-12	interleukin 1 beta	Homo sapiens	97-105
26035033-0	2017	Combination Therapies of Diacerein and Febuxostat Inhibit IL-1beta Responses and Improve Clinical Symptoms in Patients With Refractory Gout.	diacerein	25-34	interleukin 1 beta	Homo sapiens	58-66
26035033-0	2017	Combination Therapies of Diacerein and Febuxostat Inhibit IL-1beta Responses and Improve Clinical Symptoms in Patients With Refractory Gout.	Febuxostat	39-49	interleukin 1 beta	Homo sapiens	58-66
28214532-7	2017	Our results thus suggest that SMN functions as a natural inhibitor for IL-1beta-induced NF-kappaB signaling by targeting TRAF6 and the IKK complex.	(S)-(+)-Mandelic acid	30-33	interleukin 1 beta	Homo sapiens	71-79
28240768-5	2017	KEY RESULTS: In the CFA model, eucalyptol strongly attenuated oedema and mechanical allodynia and reduced levels of inflammatory cytokines (IL-1beta, TNF-alpha and IL-6), effects comparable with those of ibuprofen.	Eucalyptol	31-41	interleukin 1 beta	Homo sapiens	140-148
28131792-10	2017	Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue.	Nitrates	207-214	interleukin 1 beta	Homo sapiens	12-16
28131792-10	2017	Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue.	Nitrites	215-222	interleukin 1 beta	Homo sapiens	12-16
28131792-11	2017	Taken together, these findings suggest that IL-1 signaling in the BLA is necessary for the expression of heroin-conditioned immunosuppression of NO production and may be a target for interventions that normalize immune function in heroin users and patient populations exposed to opiate regimens.	Opiate Alkaloids	279-285	interleukin 1 beta	Homo sapiens	44-48
28240768-6	2017	In the LPS model of pulmonary inflammation, eucalyptol treatment diminished leukocyte infiltration, myeloperoxidase activity and production of TNF-alpha, IL-1beta, IFN-gamma and IL-6.	Eucalyptol	44-54	interleukin 1 beta	Homo sapiens	154-162
28062227-5	2017	A new batch of pGB cells was treated with CS, resulting in neuronal death, which could be prevented by blocking the IL-1beta in the CS by using anti-IL-1beta polyclonal antibodies.	Cesium	42-44	interleukin 1 beta	Homo sapiens	116-124
28062227-5	2017	A new batch of pGB cells was treated with CS, resulting in neuronal death, which could be prevented by blocking the IL-1beta in the CS by using anti-IL-1beta polyclonal antibodies.	Cesium	42-44	interleukin 1 beta	Homo sapiens	149-157
28062227-5	2017	A new batch of pGB cells was treated with CS, resulting in neuronal death, which could be prevented by blocking the IL-1beta in the CS by using anti-IL-1beta polyclonal antibodies.	Cesium	132-134	interleukin 1 beta	Homo sapiens	116-124
28062227-5	2017	A new batch of pGB cells was treated with CS, resulting in neuronal death, which could be prevented by blocking the IL-1beta in the CS by using anti-IL-1beta polyclonal antibodies.	Cesium	132-134	interleukin 1 beta	Homo sapiens	149-157
28062227-6	2017	Moreover, pGB cells treated with recombinant IL-1beta showed microglial proliferation and neuronal death.	Prostaglandins B	10-13	interleukin 1 beta	Homo sapiens	45-53
28013367-6	2017	Using human mesothelial cells, we first demonstrate that asbestos and carbon nanotubes induced caspase-1 activation and high-mobility group box 1, interleukin 1 beta and interleukin 18 secretion was blocked by Cytochalasin D (Cyto D) an actin polymerization inhibitor.	Asbestos	57-65	interleukin 1 beta	Homo sapiens	147-165
28362189-6	2017	The accumulating data indicates that anti IL-1 drugs are effective in treating colchicine resistant FMF cases and improving their quality of life.	Colchicine	79-89	interleukin 1 beta	Homo sapiens	42-46
28288918-7	2017	Elevations of CO2 cause oligomerization of the inflammasome components ASC, NLRP3, caspase 1, thioredoxin interacting protein, and calreticulin - a protein from endoplasmic reticulum, leading to IL-1beta synthesis.	Carbon Dioxide	14-17	interleukin 1 beta	Homo sapiens	195-203
28288918-8	2017	An increased production rate of MPs containing elevated amounts of IL-1beta persists for hours after short-term exposures to elevated CO2.	Carbon Dioxide	134-137	interleukin 1 beta	Homo sapiens	67-75
28013367-6	2017	Using human mesothelial cells, we first demonstrate that asbestos and carbon nanotubes induced caspase-1 activation and high-mobility group box 1, interleukin 1 beta and interleukin 18 secretion was blocked by Cytochalasin D (Cyto D) an actin polymerization inhibitor.	Carbon	70-76	interleukin 1 beta	Homo sapiens	147-165
28013367-6	2017	Using human mesothelial cells, we first demonstrate that asbestos and carbon nanotubes induced caspase-1 activation and high-mobility group box 1, interleukin 1 beta and interleukin 18 secretion was blocked by Cytochalasin D (Cyto D) an actin polymerization inhibitor.	Cytochalasins	210-222	interleukin 1 beta	Homo sapiens	147-165
27682001-6	2017	PFOA enhanced gene expression of several pro-inflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 by the activation of nuclear factor (NF)-kappaB in IgE-stimulated mast cells.	perfluorooctanoic acid	0-4	interleukin 1 beta	Homo sapiens	114-136
28254683-0	2017	Salvianolic acid B inhibits IL-1beta-induced inflammatory cytokine production in human osteoarthritis chondrocytes and has a protective effect in a mouse osteoarthritis model.	salvianolic acid B	0-18	interleukin 1 beta	Homo sapiens	28-36
28350048-6	2017	In addition, experiments using cells indicated that silybin significantly decreased the mRNA levels and secretion of IL-1beta and TNF-alpha in THP-1 cells.	Silybin	52-59	interleukin 1 beta	Homo sapiens	117-125
27658048-10	2017	The intracellular ROS accumulation induced by exogenous IL-1beta was responsible for the Grx1 upregulation.	Reactive Oxygen Species	18-21	interleukin 1 beta	Homo sapiens	56-64
28324042-3	2017	Objectives: We hypothesized that in obesity IL-1 antagonism would result in downregulation of the hypothalamo-pituitary-adrenal axis, leading to decreased cortisol levels.	Hydrocortisone	155-163	interleukin 1 beta	Homo sapiens	44-48
28324042-8	2017	Median morning serum cortisol levels (nmol/L) decreased significantly after IL-1 antagonism [from baseline, 452 to 423; absolute difference, -38.7; 95% confidence interval (CI), -64 to -13.4; P = 0.0019].	Hydrocortisone	21-29	interleukin 1 beta	Homo sapiens	76-80
27658048-6	2017	The ROS levels were detected in Leti-si-IL-1beta and Leti-si-NC CAL27 cells after IL-1beta stimulation.	Reactive Oxygen Species	4-7	interleukin 1 beta	Homo sapiens	40-48
28372661-10	2017	Postoperatively, plasma S-100beta and Abeta1-40 protein, IL-1beta, IL-6, and TNF-alpha concentrations were significantly decreased in the propofol group compared to the isoflurane group.	Propofol	138-146	interleukin 1 beta	Homo sapiens	57-65
28298525-0	2017	The Induction of Pro-IL-1beta by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production.	Dinoprostone	72-88	interleukin 1 beta	Homo sapiens	17-29
28298525-1	2017	PGE2 has been shown to increase the transcription of pro-IL-1beta.	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	53-65
28298525-2	2017	However, recently it has been demonstrated that PGE2 can block the maturation of IL-1beta by inhibiting the NLRP3 inflammasome in macrophages.	Dinoprostone	48-52	interleukin 1 beta	Homo sapiens	81-89
28298525-3	2017	These apparently conflicting results have led us to reexamine the effect of PGE2 on IL-1beta production.	Dinoprostone	76-80	interleukin 1 beta	Homo sapiens	84-92
28298525-4	2017	We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha.	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	199-207
28298525-4	2017	We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha.	Cyclic AMP	75-79	interleukin 1 beta	Homo sapiens	199-207
28298525-5	2017	This results in an increase in mature IL-1beta production in macrophages treated with ATP.	Adenosine Triphosphate	86-89	interleukin 1 beta	Homo sapiens	38-46
28298525-6	2017	We also examined the effect of endogenously produced PGE2 on IL-1beta production.	Dinoprostone	53-57	interleukin 1 beta	Homo sapiens	61-69
28298525-7	2017	By blocking PGE2 production with indomethacin, we made a striking finding that endogenous PGE2 is essential for LPS-induced pro-IL-1beta production, suggesting a positive feedback loop.	Dinoprostone	12-16	interleukin 1 beta	Homo sapiens	124-136
28298525-7	2017	By blocking PGE2 production with indomethacin, we made a striking finding that endogenous PGE2 is essential for LPS-induced pro-IL-1beta production, suggesting a positive feedback loop.	Indomethacin	33-45	interleukin 1 beta	Homo sapiens	124-136
28298525-7	2017	By blocking PGE2 production with indomethacin, we made a striking finding that endogenous PGE2 is essential for LPS-induced pro-IL-1beta production, suggesting a positive feedback loop.	Dinoprostone	90-94	interleukin 1 beta	Homo sapiens	124-136
28298525-9	2017	In primary human monocytes, where LPS alone is sufficient to induce mature IL-1beta, PGE2 boosted LPS-induced IL-1beta production.	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	75-83
28298525-9	2017	In primary human monocytes, where LPS alone is sufficient to induce mature IL-1beta, PGE2 boosted LPS-induced IL-1beta production.	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	110-118
28298525-11	2017	Because PGE2 mediates the pyrogenic effect of IL-1beta, these effects might be especially relevant for the role of monocytes in the induction of fever.	Dinoprostone	8-12	interleukin 1 beta	Homo sapiens	46-54
28298525-12	2017	A positive feedback loop from IL-1beta and back to PGE2, which itself is induced by IL-1beta, is likely to be operating.	Dinoprostone	51-55	interleukin 1 beta	Homo sapiens	30-38
28298525-12	2017	A positive feedback loop from IL-1beta and back to PGE2, which itself is induced by IL-1beta, is likely to be operating.	Dinoprostone	51-55	interleukin 1 beta	Homo sapiens	84-92
27658048-6	2017	The ROS levels were detected in Leti-si-IL-1beta and Leti-si-NC CAL27 cells after IL-1beta stimulation.	Reactive Oxygen Species	4-7	interleukin 1 beta	Homo sapiens	82-90
27658048-9	2017	Exogenous IL-1beta upregulated the intracellular ROS level and the expression of Grx1 in CAL27 cells, which could be counteracted by IL-1Ra.	Reactive Oxygen Species	49-52	interleukin 1 beta	Homo sapiens	10-18
27658048-11	2017	Endogenous IL-1beta acted as a switch in regulating the ROS level by modulating Grx1 expression, which was involved in the invasion and migration of OSCC cells.	Reactive Oxygen Species	56-59	interleukin 1 beta	Homo sapiens	11-19
28335600-9	2017	Compared with free NAC, the production of ROS, NO3-, NO2-, tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-1beta from the LPS-stimulated microglia was considerably decreased when the cells were pretreated with NAC-NPs.	Acetylcysteine	224-227	interleukin 1 beta	Homo sapiens	104-126
28478836-0	2017	Interleukin-1beta may act on hepatocytes to boost plasma homocysteine - The increased cardiovascular risk associated with elevated homocysteine may be mediated by this cytokine.	Homocysteine	57-69	interleukin 1 beta	Homo sapiens	0-17
28478836-2	2017	This essay proposes that interleukin-1beta can act on hepatocytes to suppress expression of the hepatocyte-specific forms of methionine adenosyltransferase; this in turn can be expected to decrease hepatic activity of cystathionine-beta-synthase, leading to an increase in plasma homocysteine.	Homocysteine	280-292	interleukin 1 beta	Homo sapiens	25-42
28447732-0	2017	Icariin inhibits MMP-1, MMP-3 and MMP-13 expression through MAPK pathways in IL-1beta-stimulated SW1353 chondrosarcoma cells.	icariin	0-7	interleukin 1 beta	Homo sapiens	77-85
28072760-2	2017	We characterized the anti-inflammatory effects of PTX toward TLR-mediated production of inflammatory (tumor necrosis factor (TNF) and interleukin (IL)-1beta) and proresolution (IL-6 and IL-10) cytokines in human newborn and adult blood.	Pentoxifylline	50-53	interleukin 1 beta	Homo sapiens	134-156
28447732-3	2017	The present study aimed to investigate the effects of Icariin on matrix metalloproteinase (MMP)-1, MMP-3 and MMP-13 expression in interleukin (IL)-1beta-stimulated human SW1353 chondrosarcoma cells, and to investigate the possible mechanism underlying the chondroprotective effects of Icariin.	icariin	54-61	interleukin 1 beta	Homo sapiens	130-152
28359359-8	2017	The increase of 1 g/1000 kcal in PUFAs, omega-3, and omega-6 reduces, on average, 6%, 48%, and 8% respectively, the mean concentration of IL-1 beta.	Fatty Acids, Unsaturated	33-38	interleukin 1 beta	Homo sapiens	138-147
28359359-8	2017	The increase of 1 g/1000 kcal in PUFAs, omega-3, and omega-6 reduces, on average, 6%, 48%, and 8% respectively, the mean concentration of IL-1 beta.	omega-3	40-47	interleukin 1 beta	Homo sapiens	138-147
28359359-8	2017	The increase of 1 g/1000 kcal in PUFAs, omega-3, and omega-6 reduces, on average, 6%, 48%, and 8% respectively, the mean concentration of IL-1 beta.	omega-6	53-60	interleukin 1 beta	Homo sapiens	138-147
28707668-8	2017	It has been demonstrated that, in cells transfected with HCV genes, DFMO reduces the production of three out of four tested cytokines, namely, TNF-alpha and TGF-beta in cells that express HCV core, E1E2, NS3, NS5A, and NS5B proteins, and IL-1beta in the cells that express HCV core, E1E2, and NS3 proteins.	Eflornithine	68-72	interleukin 1 beta	Homo sapiens	238-246
28072760-5	2017	RESULTS: Whether added 2 h pre-, simultaneously to, or 2 h post-TLR stimulation, PTX inhibited TLR-mediated cytokine production in a concentration-dependent manner, with greater efficacy and potency in newborn blood, decreasing intracellular TNF and IL-1beta with relative preservation of IL-10 and IL-6.	Pentoxifylline	81-84	interleukin 1 beta	Homo sapiens	250-258
28554965-4	2017	In addition, inhibition of interleukin-1 (IL-1) signaling by anakinra, a recombinant human IL-1Ra, or a murinized anti-IL-1beta antibody attenuates the inflammatory and ultimate cell death response elicited by FetA alone or combined with palmitic acid.	Palmitic Acid	238-251	interleukin 1 beta	Homo sapiens	119-127
28554965-6	2017	In summary, our results suggest that FetA similarly to LPS leads to an inflammatory response in podocytes, which exacerbates palmitic acid-induced podocyte death and our data imply a critical role for IL-1beta signaling in this process.	Palmitic Acid	125-138	interleukin 1 beta	Homo sapiens	201-209
28920396-6	2017	Also, based on both in vitro and in vivo investigation, NACOS evidently down-regulated the expression of lipid metabolism-related regulators (PGC1alpha, Cox5b, Mcad) and inflammatory cytokine (IL-1beta) at mRNA level (P&lt;0.05 or 0.01), and suppressed the activation of p38, ERK1/2 and Akt in HepG2 cells and lever tissues from HFD-fed mice (P&lt;0.05 or 0.01).	nacos	56-61	interleukin 1 beta	Homo sapiens	193-201
28188160-10	2017	H2S inhibited the expression of CAPs, NF-kappaB activation and the production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor alpha (TNFalpha) in cultured USMCs.	Hydrogen Sulfide	0-3	interleukin 1 beta	Homo sapiens	81-103
28188160-11	2017	IL-1beta treatment reversed H2S inhibition of CAPs.	Hydrogen Sulfide	28-31	interleukin 1 beta	Homo sapiens	0-8
27638291-9	2017	Functional studies using p62 small interfering RNA (siRNA) demonstrated a significant attenuation of TNF-alpha- and IL-1beta-induced proinflammatory cytokines (IL-6) and chemokine (IL-8 and monocyte chemoattractant protein 1 [MCP-1]) mRNA expression and secretion, expression of cyclooxygenase 2, release of prostaglandin F2alpha (PGF2alpha), and expression of the prostaglandin F receptor (FP).	Dinoprost	308-329	interleukin 1 beta	Homo sapiens	116-124
27638291-9	2017	Functional studies using p62 small interfering RNA (siRNA) demonstrated a significant attenuation of TNF-alpha- and IL-1beta-induced proinflammatory cytokines (IL-6) and chemokine (IL-8 and monocyte chemoattractant protein 1 [MCP-1]) mRNA expression and secretion, expression of cyclooxygenase 2, release of prostaglandin F2alpha (PGF2alpha), and expression of the prostaglandin F receptor (FP).	Dinoprost	331-340	interleukin 1 beta	Homo sapiens	116-124
28151075-9	2017	In multiple SNP analysis, TC haplotype within the IL1 polymorphisms significantly decreased the risk of the infection in pregnant women (OR 0.38 95% CI 0.15-0.96; p &lt;= 0.050).	Technetium	26-28	interleukin 1 beta	Homo sapiens	50-53
28430129-5	2017	In the present study, we investigated the protective mechanisms of curcumin on interleukin 1beta (IL-1beta)-stimulated primary chondrocytes in vitro.	Curcumin	67-75	interleukin 1 beta	Homo sapiens	79-96
28430129-5	2017	In the present study, we investigated the protective mechanisms of curcumin on interleukin 1beta (IL-1beta)-stimulated primary chondrocytes in vitro.	Curcumin	67-75	interleukin 1 beta	Homo sapiens	98-106
28430129-7	2017	Co-treatment of curcumin with IL-1beta significantly decreased the growth inhibition.	Curcumin	16-24	interleukin 1 beta	Homo sapiens	30-38
28430129-8	2017	We observed that curcumin inhibited IL-1beta-induced apoptosis and caspase-3 activation in chondrocytes.	Curcumin	17-25	interleukin 1 beta	Homo sapiens	36-44
28284336-2	2017	Here we show that PAR treatment inhibits the initiation of experimental autoimmune neuritis (EAN), suppresses the production of TNF-alpha, IFN-gamma, IL-1beta and IL-17, and decreases Th1 and Th17 cells at early time point.	parthenolide	18-21	interleukin 1 beta	Homo sapiens	150-158
28404891-3	2017	HMGB1 and the pro-inflammatory cytokines IL-1beta and TNF-alpha were gradually released from NB4 and HL-60 cells treated with ATRA and/or ATO.	Tretinoin	126-130	interleukin 1 beta	Homo sapiens	41-49
28404891-3	2017	HMGB1 and the pro-inflammatory cytokines IL-1beta and TNF-alpha were gradually released from NB4 and HL-60 cells treated with ATRA and/or ATO.	Arsenic Trioxide	138-141	interleukin 1 beta	Homo sapiens	41-49
28422993-9	2017	Anti-inflammatory vitamin D interfered with the IL-1beta release and suppressed caspase-5 in keratinocytes and in psoriatic skin lesions.	Vitamin D	18-27	interleukin 1 beta	Homo sapiens	48-56
28386088-4	2017	Further study in human amnion fibroblasts showed that SAA1 production was augmented by interleukin-1beta (IL-1beta) and cortisol alone and synergistically, and SAA1 in turn induced the expression of IL-1beta, interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and PGE2 production.	Dinoprostone	260-264	interleukin 1 beta	Homo sapiens	87-104
28383530-8	2017	The petroleum ether extract, the ethyl acetate extract and decarine showed anti-inflammatory activities through inhibiting TNF-alpha and IL-1beta production in lipopolysaccharide-stimulated THP-1 cells without cell toxicity too.	naphtha	4-19	interleukin 1 beta	Homo sapiens	137-145
31305644-0	2017	Erratum: Hypertonic saline protects brain endothelial cells against hypoxia correlated to the levels of estimated glomerular filtration rate and interleukin-1beta: Erratum.	Sodium Chloride	20-26	interleukin 1 beta	Homo sapiens	145-162
28383530-8	2017	The petroleum ether extract, the ethyl acetate extract and decarine showed anti-inflammatory activities through inhibiting TNF-alpha and IL-1beta production in lipopolysaccharide-stimulated THP-1 cells without cell toxicity too.	ethyl acetate	33-46	interleukin 1 beta	Homo sapiens	137-145
28383530-8	2017	The petroleum ether extract, the ethyl acetate extract and decarine showed anti-inflammatory activities through inhibiting TNF-alpha and IL-1beta production in lipopolysaccharide-stimulated THP-1 cells without cell toxicity too.	Decarine	59-67	interleukin 1 beta	Homo sapiens	137-145
28383530-9	2017	Decarine showed anti-inflammatory activity on human colon cells by reducing IL-6 and IL-8 production in TNF-alpha+IL-1beta-induced Caco-2 cells.	Decarine	0-8	interleukin 1 beta	Homo sapiens	114-122
28386088-4	2017	Further study in human amnion fibroblasts showed that SAA1 production was augmented by interleukin-1beta (IL-1beta) and cortisol alone and synergistically, and SAA1 in turn induced the expression of IL-1beta, interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and PGE2 production.	Dinoprostone	260-264	interleukin 1 beta	Homo sapiens	199-207
28421077-4	2017	Secretion of the pro-inflammatory cytokines interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha induced by exposure to the silica particles had a bell-shaped distribution, where the maximal secretion was induced by silica nanoparticles with a diameter of 50 nm and particles with smaller or larger diameters had progressively less effect.	Silicon Dioxide	132-138	interleukin 1 beta	Homo sapiens	44-66
28421077-5	2017	We found that blockade of IL-1beta secretion markedly inhibited TNF-alpha secretion, suggesting that IL-1beta is upstream of TNF-alpha in the inflammatory cascade induced by exposure to silica particles, and that the induction of IL-1beta secretion was dependent on both the NLRP3 inflammasome and on uptake of the silica particles into the cells via endocytosis.	Silicon Dioxide	315-321	interleukin 1 beta	Homo sapiens	101-109
28421072-2	2017	Triggering of toll-like receptors by pathogen-associated molecular pattern or damage-associated molecular pattern (PAMP or DAMP) molecules generates reactive oxygen species that in turn induce production and activation of pro-inflammatory cytokines such as IL-1beta.	Reactive Oxygen Species	149-172	interleukin 1 beta	Homo sapiens	257-265
28421077-4	2017	Secretion of the pro-inflammatory cytokines interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha induced by exposure to the silica particles had a bell-shaped distribution, where the maximal secretion was induced by silica nanoparticles with a diameter of 50 nm and particles with smaller or larger diameters had progressively less effect.	Silicon Dioxide	224-230	interleukin 1 beta	Homo sapiens	44-66
28421077-7	2017	Further investigation revealed that the induction of IL-1beta secretion and uptake of silica nanoparticles with diameters of 50 or 100 nm, but not of 10 or 1,000 nm, was dependent on scavenger receptor (SR) A1.	Silicon Dioxide	86-92	interleukin 1 beta	Homo sapiens	53-61
28421077-8	2017	In addition, of the silica particles examined, only those with a diameter of 50 nm induced strong IL-1beta secretion via activation of Mer receptor tyrosine kinase, a signal mediator of SR A1.	Silicon Dioxide	20-26	interleukin 1 beta	Homo sapiens	98-106
28421077-5	2017	We found that blockade of IL-1beta secretion markedly inhibited TNF-alpha secretion, suggesting that IL-1beta is upstream of TNF-alpha in the inflammatory cascade induced by exposure to silica particles, and that the induction of IL-1beta secretion was dependent on both the NLRP3 inflammasome and on uptake of the silica particles into the cells via endocytosis.	Silicon Dioxide	186-192	interleukin 1 beta	Homo sapiens	26-34
28421077-5	2017	We found that blockade of IL-1beta secretion markedly inhibited TNF-alpha secretion, suggesting that IL-1beta is upstream of TNF-alpha in the inflammatory cascade induced by exposure to silica particles, and that the induction of IL-1beta secretion was dependent on both the NLRP3 inflammasome and on uptake of the silica particles into the cells via endocytosis.	Silicon Dioxide	186-192	interleukin 1 beta	Homo sapiens	101-109
28421077-5	2017	We found that blockade of IL-1beta secretion markedly inhibited TNF-alpha secretion, suggesting that IL-1beta is upstream of TNF-alpha in the inflammatory cascade induced by exposure to silica particles, and that the induction of IL-1beta secretion was dependent on both the NLRP3 inflammasome and on uptake of the silica particles into the cells via endocytosis.	Silicon Dioxide	186-192	interleukin 1 beta	Homo sapiens	101-109
28421077-5	2017	We found that blockade of IL-1beta secretion markedly inhibited TNF-alpha secretion, suggesting that IL-1beta is upstream of TNF-alpha in the inflammatory cascade induced by exposure to silica particles, and that the induction of IL-1beta secretion was dependent on both the NLRP3 inflammasome and on uptake of the silica particles into the cells via endocytosis.	Silicon Dioxide	315-321	interleukin 1 beta	Homo sapiens	26-34
28421077-5	2017	We found that blockade of IL-1beta secretion markedly inhibited TNF-alpha secretion, suggesting that IL-1beta is upstream of TNF-alpha in the inflammatory cascade induced by exposure to silica particles, and that the induction of IL-1beta secretion was dependent on both the NLRP3 inflammasome and on uptake of the silica particles into the cells via endocytosis.	Silicon Dioxide	315-321	interleukin 1 beta	Homo sapiens	101-109
28367997-3	2017	When added to cell cultures, PFDA significantly stimulated IL-1beta and IL18 secretion and their mRNA levels compared with control cells.	perfluorodecanoic acid	29-33	interleukin 1 beta	Homo sapiens	59-67
27592000-9	2017	The mechanism of PCP stimulation of IL1-beta secretion was also addressed, and it appears that the MAPKs, ERK1/2 and p38, may be utilized by PCP to stimulate secretion of IL-1beta.	Pentachlorophenol	17-20	interleukin 1 beta	Homo sapiens	171-179
28249988-7	2017	Pretreatment with curcumin significantly attenuated LPS-induced secretion of master cytokine IL-1beta from IECs and macrophages.	Curcumin	18-26	interleukin 1 beta	Homo sapiens	93-101
28249988-8	2017	Furthermore, curcumin also reduced IL-1beta-induced activation of p38 MAPK in IECs and subsequent increase in expression of myosin light chain kinase involved in the phosphorylation of tight junction proteins and ensuing disruption of their normal arrangement.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	35-43
28299617-6	2017	In particular, methyl caffeate down-regulated SASP factors such as IL-1alpha, IL-1beta, IL-6, IL-8, GM-CSF, CXCL1, MCP-2, and MMP-3.	methyl caffeate	15-30	interleukin 1 beta	Homo sapiens	78-86
27592000-0	2017	Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1beta) from human immune cells.	Pentachlorophenol	41-58	interleukin 1 beta	Homo sapiens	127-145
27592000-0	2017	Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1beta) from human immune cells.	Pentachlorophenol	41-58	interleukin 1 beta	Homo sapiens	147-155
27592000-0	2017	Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1beta) from human immune cells.	Pentachlorophenol	60-63	interleukin 1 beta	Homo sapiens	127-145
27592000-0	2017	Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1beta) from human immune cells.	Pentachlorophenol	60-63	interleukin 1 beta	Homo sapiens	147-155
27592000-0	2017	Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1beta) from human immune cells.	DDT	69-100	interleukin 1 beta	Homo sapiens	127-145
27592000-0	2017	Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1beta) from human immune cells.	DDT	69-100	interleukin 1 beta	Homo sapiens	147-155
27592000-0	2017	Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1beta) from human immune cells.	DDT	102-105	interleukin 1 beta	Homo sapiens	127-145
27592000-0	2017	Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1beta) from human immune cells.	DDT	102-105	interleukin 1 beta	Homo sapiens	147-155
27592000-4	2017	Here, PCP and DDT were examined for their ability to alter secretion of IL-1beta from immune cell preparations of various complexity: NK cells; monocyte-depleted (MD) peripheral blood mononuclear cells (PBMCS); and PBMCs.	Pentachlorophenol	6-9	interleukin 1 beta	Homo sapiens	72-80
27592000-4	2017	Here, PCP and DDT were examined for their ability to alter secretion of IL-1beta from immune cell preparations of various complexity: NK cells; monocyte-depleted (MD) peripheral blood mononuclear cells (PBMCS); and PBMCs.	DDT	14-17	interleukin 1 beta	Homo sapiens	72-80
27592000-6	2017	Results showed that both PCP and DDT increased IL-1beta secretion from all of the immune cell preparations.	Pentachlorophenol	25-28	interleukin 1 beta	Homo sapiens	47-55
27592000-6	2017	Results showed that both PCP and DDT increased IL-1beta secretion from all of the immune cell preparations.	DDT	33-36	interleukin 1 beta	Homo sapiens	47-55
27592000-7	2017	The specific concentrations of PCP and DDT that increased IL-1beta secretion varied by donor.	Pentachlorophenol	31-34	interleukin 1 beta	Homo sapiens	58-66
27592000-7	2017	The specific concentrations of PCP and DDT that increased IL-1beta secretion varied by donor.	DDT	39-42	interleukin 1 beta	Homo sapiens	58-66
27592000-9	2017	The mechanism of PCP stimulation of IL1-beta secretion was also addressed, and it appears that the MAPKs, ERK1/2 and p38, may be utilized by PCP to stimulate secretion of IL-1beta.	Pentachlorophenol	17-20	interleukin 1 beta	Homo sapiens	36-44
28050702-0	2017	Selective induction of IL-1beta after a brief isoflurane anesthetic in children undergoing MRI examination.	Isoflurane	46-56	interleukin 1 beta	Homo sapiens	23-31
26435068-0	2017	Carbon monoxide decreases interleukin-1beta levels in the lung through the induction of pyrin.	Carbon Monoxide	0-15	interleukin 1 beta	Homo sapiens	26-43
26435068-7	2017	Genetic interference of pyrin by siRNA increased IL-1beta production in response to LPS and ATP, and reversed CORM-2-dependent inhibition of caspase-1 activation.	Adenosine Triphosphate	92-95	interleukin 1 beta	Homo sapiens	49-57
27315572-0	2017	Autocrine TNF-alpha and IL-1beta prime 6-sulfo LacNAc+ dendritic cells for high-level production of IL-23.	6-sulfo	39-46	interleukin 1 beta	Homo sapiens	24-32
27003335-8	2017	Treatment with simvastatin significantly attenuated LPS-stimulated production of IL-1beta, IL-6, VCAM-1 and ICAM-1 (P &lt; 0.05).	Simvastatin	15-26	interleukin 1 beta	Homo sapiens	81-89
28213268-0	2017	Fisetin inhibits IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice.	fisetin	0-7	interleukin 1 beta	Homo sapiens	17-25
28290607-5	2017	NP and PP both promoted the inflammatory response by upregulating neutrophil infiltration and interleukin (IL)-1beta expression, and downregulating IL-10 expression.	Neptunium	0-2	interleukin 1 beta	Homo sapiens	94-116
28979306-2	2017	In this study, quantitative relationships between the structures of 46 pyridazine derivatives (inhibitors of IL-1beta production) and their activities were investigated by Multiple Linear Regression (MLR) technique Stepwise Regression Method (ES-SWR).	pyridazine	71-81	interleukin 1 beta	Homo sapiens	109-117
28368291-0	2017	Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.	Glucose	0-7	interleukin 1 beta	Homo sapiens	40-48
28093282-0	2017	IL-1beta induces up-regulation of BIRC3, a gene involved in chemoresistance to doxorubicin in breast cancer cells.	Doxorubicin	79-90	interleukin 1 beta	Homo sapiens	0-8
28093282-8	2017	Cells stimulated with IL-1beta when challenged with doxorubicin showed resistance to the drug, whereas silencing of BIRC3 decreased viability of the cells treated with the drug.	Doxorubicin	52-63	interleukin 1 beta	Homo sapiens	22-30
28093282-9	2017	Our present results show that IL-1beta confers doxorubicin resistance to breast cancer cells, underlining the importance of an inflammatory environment in cancer malignancy.	Doxorubicin	47-58	interleukin 1 beta	Homo sapiens	30-38
27315572-0	2017	Autocrine TNF-alpha and IL-1beta prime 6-sulfo LacNAc+ dendritic cells for high-level production of IL-23.	N-acetyllactosamine	47-53	interleukin 1 beta	Homo sapiens	24-32
28601049-9	2017	Conducting the study on larger number of patients and also measuring cytokines levels including TNF-alpha and IL-1beta may clarify the underlying mechanisms of the anti-inflammatory effects of silymarin in RA patients.	Silymarin	193-202	interleukin 1 beta	Homo sapiens	110-118
28050702-16	2017	CONCLUSIONS: A brief (approximately 60 min) exposure to isoflurane general anesthesia, without induced surgical stress, significantly increased serum IL-1beta, a selective activation marker of systemic inflammation (IL-1beta pathway).	Isoflurane	56-66	interleukin 1 beta	Homo sapiens	150-158
28050702-16	2017	CONCLUSIONS: A brief (approximately 60 min) exposure to isoflurane general anesthesia, without induced surgical stress, significantly increased serum IL-1beta, a selective activation marker of systemic inflammation (IL-1beta pathway).	Isoflurane	56-66	interleukin 1 beta	Homo sapiens	216-224
28050702-13	2017	RESULTS: For all patients, interleukin-1beta increased after isoflurane when compared to pre-isoflurane samples (pre = 25.97 +- 9.01, post = 38.53 +- 16.56, p = 0.0002).	Isoflurane	61-71	interleukin 1 beta	Homo sapiens	27-44
27827528-9	2017	Moreover, PBSu and PBSu/TCP significantly suppressed the expression of IL-1beta and IL-6 genes by 15-35% and 21-26%, respectively.	bionole	10-14	interleukin 1 beta	Homo sapiens	71-79
28027970-0	2017	HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1beta production via suppressing the NF-kappaB pathway and ROS production.	Reactive Oxygen Species	121-124	interleukin 1 beta	Homo sapiens	59-67
27827528-9	2017	Moreover, PBSu and PBSu/TCP significantly suppressed the expression of IL-1beta and IL-6 genes by 15-35% and 21-26%, respectively.	bionole	19-23	interleukin 1 beta	Homo sapiens	71-79
27827528-9	2017	Moreover, PBSu and PBSu/TCP significantly suppressed the expression of IL-1beta and IL-6 genes by 15-35% and 21-26%, respectively.	tcp	24-27	interleukin 1 beta	Homo sapiens	71-79
28314592-3	2017	By sensing the differential localization of ROS generated in response to microbes of different size, neutrophils tuned their interleukin (IL)-1beta expression via the selective oxidation of NF-kappaB, in order to implement distinct inflammatory programs.	Reactive Oxygen Species	44-47	interleukin 1 beta	Homo sapiens	125-147
28176142-8	2017	Pre-treatment with p38MAPK inhibitor SB203580 decreased the levels of TNF-alpha and IL-1beta, while downregulation of TLR4 significantly reduced HMGB1-induced p38MAPK signaling pathway activation.	SB 203580	37-45	interleukin 1 beta	Homo sapiens	84-92
28012441-5	2017	Moreover, UgU elicited mitochondrial superoxide generation in a dose-dependent manner, and a specific scavenger of mitochondrial reactive oxygen species (ROS) diminished UgU-induced IL-1beta and caspase-1 activation.	Reactive Oxygen Species	129-152	interleukin 1 beta	Homo sapiens	182-190
28012441-5	2017	Moreover, UgU elicited mitochondrial superoxide generation in a dose-dependent manner, and a specific scavenger of mitochondrial reactive oxygen species (ROS) diminished UgU-induced IL-1beta and caspase-1 activation.	Reactive Oxygen Species	154-157	interleukin 1 beta	Homo sapiens	182-190
28345644-5	2017	Vitamin D had no effect on BEAS-2B cells but enhanced the production of IL-8 in neutrophils (p = 0.007) and IL-1beta in macrophages (p = 0.007) in response to LPS.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	108-116
28341848-5	2017	Knockdown of p62 abrogated the suppressive effects of gAcrp on LPS-stimulated TNF-alpha and IL-1beta expression and TRAF6/p38 MAPK pathway, indicating that p62 signaling is critical for suppressing inflammatory cytokines production by gAcrp.	gacrp	54-59	interleukin 1 beta	Homo sapiens	92-100
28334039-0	2017	L-arginine attenuates Interleukin-1beta (IL-1beta) induced Nuclear Factor Kappa-Beta (NF-kappaB) activation in Caco-2 cells.	Arginine	0-10	interleukin 1 beta	Homo sapiens	22-39
28334039-0	2017	L-arginine attenuates Interleukin-1beta (IL-1beta) induced Nuclear Factor Kappa-Beta (NF-kappaB) activation in Caco-2 cells.	Arginine	0-10	interleukin 1 beta	Homo sapiens	41-49
28334039-6	2017	Finally, the effects of sodium nitroprusside (SNP, a NO donor) and Nomega-nitro-L-arginine (NNA, an iNOS inhibitor) on IL-1beta-mediated NF-kappaB-activation were examined.	Nitroarginine	67-90	interleukin 1 beta	Homo sapiens	119-127
28334039-6	2017	Finally, the effects of sodium nitroprusside (SNP, a NO donor) and Nomega-nitro-L-arginine (NNA, an iNOS inhibitor) on IL-1beta-mediated NF-kappaB-activation were examined.	Nitroarginine	92-95	interleukin 1 beta	Homo sapiens	119-127
28334039-7	2017	RESULTS: IL-1beta increased NF-kappaB luciferase activity (8-fold) and NF-kappaB expression (mRNA and protein), both of these were significantly decreased by L-Arg.	Arginine	158-163	interleukin 1 beta	Homo sapiens	9-17
28334039-9	2017	SNP attenuated the IL-1beta-induced increase in NF-kappaB luciferase activity and expression, whereas NNA diminished the inhibitory effects of L-Arg on IL-1beta-inducible NF- kappaB luciferase activity.	Nitroarginine	102-105	interleukin 1 beta	Homo sapiens	152-160
28377715-6	2017	Mechanistically, dioscin significantly decreased the protein levels of TLR4, MyD88, TRAF6, TKB1, TRAF3, phosphorylation levels of PI3K, Akt, IkappaBalpha, NF-kappaB, and the mRNA levels of IL-1beta, IL-6, and TNF-alpha against oxidative stress and inflammation (p &lt; 0.05).	dioscin	17-24	interleukin 1 beta	Homo sapiens	189-197
28386381-8	2017	RESULTS: In cells treated with lycopene and LPS, the mRNA expression of TNF-alpha, IL-1beta, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P &lt; 0.05).	Lycopene	31-39	interleukin 1 beta	Homo sapiens	83-91
28386381-11	2017	CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.	Lycopene	13-21	interleukin 1 beta	Homo sapiens	133-141
28356505-1	2017	The NLRP3 inflammasome/caspase-1/IL-1beta axis may be a therapeutic target in severe steroid-resistant asthma.	Steroids	85-92	interleukin 1 beta	Homo sapiens	33-41
28334039-9	2017	SNP attenuated the IL-1beta-induced increase in NF-kappaB luciferase activity and expression, whereas NNA diminished the inhibitory effects of L-Arg on IL-1beta-inducible NF- kappaB luciferase activity.	Arginine	143-148	interleukin 1 beta	Homo sapiens	152-160
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	38-43	interleukin 1 beta	Homo sapiens	47-55
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	38-43	interleukin 1 beta	Homo sapiens	158-166
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	110-115	interleukin 1 beta	Homo sapiens	47-55
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	43-48	interleukin 1 beta	Homo sapiens	165-173
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	156-161	interleukin 1 beta	Homo sapiens	165-173
28314592-4	2017	Small microbes triggered ROS intracellularly, suppressing IL-1beta expression to limit neutrophil recruitment as each phagocyte eliminated numerous pathogens.	Reactive Oxygen Species	25-28	interleukin 1 beta	Homo sapiens	58-66
28314592-5	2017	In contrast, large microbes triggered ROS extracellularly, amplifying IL-1beta expression to recruit numerous neutrophils forming cooperative clusters.	Reactive Oxygen Species	38-41	interleukin 1 beta	Homo sapiens	70-78
28278187-6	2017	Treatment with resveratrol significantly reduced the expression and secretion of pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta and pro-inflammatory chemokines IL-8 and MCP-1 in human placenta and omental and subcutaneous adipose tissue.	Resveratrol	15-26	interleukin 1 beta	Homo sapiens	125-133
28188892-0	2017	The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1beta release-Possible role of glutathione.	hydroxyethyl methacrylate	19-44	interleukin 1 beta	Homo sapiens	91-99
28188892-0	2017	The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1beta release-Possible role of glutathione.	hydroxyethyl methacrylate	46-50	interleukin 1 beta	Homo sapiens	91-99
28188892-7	2017	The GSH modulators butylsulfoximine (BSO; inhibitor of GSH synthesis) and 2-oxothiazolidine-4-carboxylate (OTC; Cysteine precursor) caused a decrease and increase in the LPS-induced IL-1beta release, respectively, suggesting a role for GSH in negative regulation of LPS-induced IL-1beta release.	Glutathione	4-7	interleukin 1 beta	Homo sapiens	182-190
28188892-7	2017	The GSH modulators butylsulfoximine (BSO; inhibitor of GSH synthesis) and 2-oxothiazolidine-4-carboxylate (OTC; Cysteine precursor) caused a decrease and increase in the LPS-induced IL-1beta release, respectively, suggesting a role for GSH in negative regulation of LPS-induced IL-1beta release.	Glutathione	4-7	interleukin 1 beta	Homo sapiens	278-286
28188892-7	2017	The GSH modulators butylsulfoximine (BSO; inhibitor of GSH synthesis) and 2-oxothiazolidine-4-carboxylate (OTC; Cysteine precursor) caused a decrease and increase in the LPS-induced IL-1beta release, respectively, suggesting a role for GSH in negative regulation of LPS-induced IL-1beta release.	butylsulfoximine	19-35	interleukin 1 beta	Homo sapiens	182-190
28188892-7	2017	The GSH modulators butylsulfoximine (BSO; inhibitor of GSH synthesis) and 2-oxothiazolidine-4-carboxylate (OTC; Cysteine precursor) caused a decrease and increase in the LPS-induced IL-1beta release, respectively, suggesting a role for GSH in negative regulation of LPS-induced IL-1beta release.	butylsulfoximine	19-35	interleukin 1 beta	Homo sapiens	278-286
28188892-7	2017	The GSH modulators butylsulfoximine (BSO; inhibitor of GSH synthesis) and 2-oxothiazolidine-4-carboxylate (OTC; Cysteine precursor) caused a decrease and increase in the LPS-induced IL-1beta release, respectively, suggesting a role for GSH in negative regulation of LPS-induced IL-1beta release.	2-oxothiazolidine-4-carboxylic acid	74-105	interleukin 1 beta	Homo sapiens	182-190
28188892-7	2017	The GSH modulators butylsulfoximine (BSO; inhibitor of GSH synthesis) and 2-oxothiazolidine-4-carboxylate (OTC; Cysteine precursor) caused a decrease and increase in the LPS-induced IL-1beta release, respectively, suggesting a role for GSH in negative regulation of LPS-induced IL-1beta release.	2-oxothiazolidine-4-carboxylic acid	74-105	interleukin 1 beta	Homo sapiens	278-286
28288585-4	2017	Previous report in our group demonstrated hypertonic saline (HS) could reduce the release of interleukin-1 beta and tumor necrosis factor-alpha in activated microglia, but the underlying molecular and cellular mechanisms have remained uncertain.	Sodium Chloride	61-63	interleukin 1 beta	Homo sapiens	93-143
28232992-7	2017	Overall, glutaraldehyde immobilisation was effective for BNP assays, but yielded unacceptable background for IL-1beta and cTnI assays caused by direct binding of the biotinylated detection antibody to the modified PVOH surface.	Glutaral	9-23	interleukin 1 beta	Homo sapiens	109-117
28056339-3	2017	We recently found that asbestos activates the nod-like receptor family member containing a pyrin domain 3 (NLRP3) inflammasome in a protracted manner, leading to an up-regulation of IL-1beta and IL-18 production in human mesothelial cells.	Asbestos	23-31	interleukin 1 beta	Homo sapiens	182-190
28273917-4	2017	Results demonstrate that cap (0.1-25 microM) significantly (p &lt; 0.05) inhibited the release of prostaglandin E2 (PGE2), 8-iso-PGF2alpha, and differentially regulated the levels of cytokines (TNF-alpha, IL-6 &amp; IL-1beta).	Capsaicin	25-28	interleukin 1 beta	Homo sapiens	216-224
28273458-6	2017	Consequently, deletion of the RIPK3 RHIM in CD11c+ cells alone was sufficient to impair dextran sodium sulfate (DSS)-induced interleukin (IL)-23 and IL-1beta expression, leading to severe intestinal inflammation.	dextran sodium sulfate	88-110	interleukin 1 beta	Homo sapiens	149-157
28273458-6	2017	Consequently, deletion of the RIPK3 RHIM in CD11c+ cells alone was sufficient to impair dextran sodium sulfate (DSS)-induced interleukin (IL)-23 and IL-1beta expression, leading to severe intestinal inflammation.	dss	112-115	interleukin 1 beta	Homo sapiens	149-157
28266599-6	2017	After stimulation of ORS cells with the double-stranded (ds)RNA mimic polyinosinic:polycytidylic acid (poly[I:C]), the activation of caspase-1 and secretion of IL-1beta were enhanced.	Poly C	83-101	interleukin 1 beta	Homo sapiens	160-168
28253907-8	2017	Time-matched (acquired within 5 h of each other) serum cytokine and MRS showed correlations between Lac/NAA and serum IL-1beta and IL-10 (all p &lt; 0.01).	Lactose	100-103	interleukin 1 beta	Homo sapiens	118-126
28253907-8	2017	Time-matched (acquired within 5 h of each other) serum cytokine and MRS showed correlations between Lac/NAA and serum IL-1beta and IL-10 (all p &lt; 0.01).	N-acetylaspartate	104-107	interleukin 1 beta	Homo sapiens	118-126
28387889-12	2017	Ketamine is more effective in reducing inflammatory factors including IL-1beta, Caspase-1, and NF-kappaB than propofol.	Ketamine	0-8	interleukin 1 beta	Homo sapiens	70-78
28002754-8	2017	Finally, we found that uptake of aggregation-prone iron nanomedicines by peripheral blood mononuclear cells in whole blood induced production of the proinflammatory cytokine IL-1beta, but not IL-6.	Iron	51-55	interleukin 1 beta	Homo sapiens	174-182
26961545-7	2017	The presence of ATP during TLR4 activation leads to NLRP3 inflammasome activation and caspase-1-mediated IL-1beta secretion which was inhibited during CD40 activation, accompanied with inhibition of ERK1/2 and reactive oxygen species (ROS), and elevation in p38 MAPK phosphorylation.	Adenosine Triphosphate	16-19	interleukin 1 beta	Homo sapiens	105-113
26961545-7	2017	The presence of ATP during TLR4 activation leads to NLRP3 inflammasome activation and caspase-1-mediated IL-1beta secretion which was inhibited during CD40 activation, accompanied with inhibition of ERK1/2 and reactive oxygen species (ROS), and elevation in p38 MAPK phosphorylation.	Reactive Oxygen Species	235-238	interleukin 1 beta	Homo sapiens	105-113
27996196-8	2017	Fenofibrate at concentrations of 25-50 uM blunted the IL-1beta induced production of ENA-78 (p &lt; 0.05) with no significant effects on RANTES and IL-8.	Fenofibrate	0-11	interleukin 1 beta	Homo sapiens	54-62
27853846-0	2017	Location and gene-specific effects of methylprednisolone acetate on mitigating IL1beta-induced inflammation in mature ovine explant knee tissue.	Methylprednisolone Acetate	38-64	interleukin 1 beta	Homo sapiens	79-86
27843000-0	2017	Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-kappaB, CCR1, chemokine CCL5/RANTES and interleukin-1beta in PBMC allergic and non-allergic patients.	osthol	66-73	interleukin 1 beta	Homo sapiens	162-179
27843000-0	2017	Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-kappaB, CCR1, chemokine CCL5/RANTES and interleukin-1beta in PBMC allergic and non-allergic patients.	Histamine	38-47	interleukin 1 beta	Homo sapiens	162-179
27853846-1	2017	OBJECTIVE AND DESIGN: To determine the ability of methylprednisolone acetate (MPA) to influence interleukin 1beta (IL1beta)-induced gene expression in ovine knee joint tissues.	Methylprednisolone Acetate	50-76	interleukin 1 beta	Homo sapiens	96-113
27853846-1	2017	OBJECTIVE AND DESIGN: To determine the ability of methylprednisolone acetate (MPA) to influence interleukin 1beta (IL1beta)-induced gene expression in ovine knee joint tissues.	Methylprednisolone Acetate	50-76	interleukin 1 beta	Homo sapiens	115-122
28064010-6	2017	NLRP3 inflammasome was found to mediate IL-1beta secretion through the production of ROS (reactive oxygen species) during the senescence of endothelial cells.	Reactive Oxygen Species	85-88	interleukin 1 beta	Homo sapiens	40-48
27853846-1	2017	OBJECTIVE AND DESIGN: To determine the ability of methylprednisolone acetate (MPA) to influence interleukin 1beta (IL1beta)-induced gene expression in ovine knee joint tissues.	Methylprednisolone Acetate	78-81	interleukin 1 beta	Homo sapiens	96-113
28064010-6	2017	NLRP3 inflammasome was found to mediate IL-1beta secretion through the production of ROS (reactive oxygen species) during the senescence of endothelial cells.	Reactive Oxygen Species	90-113	interleukin 1 beta	Homo sapiens	40-48
27853846-1	2017	OBJECTIVE AND DESIGN: To determine the ability of methylprednisolone acetate (MPA) to influence interleukin 1beta (IL1beta)-induced gene expression in ovine knee joint tissues.	Methylprednisolone Acetate	78-81	interleukin 1 beta	Homo sapiens	115-122
27853847-0	2017	Macrophage-derived IL-1beta enhances monosodium urate crystal-triggered NET formation.	Uric Acid	37-53	interleukin 1 beta	Homo sapiens	19-27
28204817-0	2017	Resveratrol inhibits the IL-1beta-induced expression of MMP-13 and IL-6 in human articular chondrocytes via TLR4/MyD88-dependent and -independent signaling cascades.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	25-33
28204817-4	2017	The aim of this study was to determine whether the biological effects of resveratrol against interleukin (IL)-1beta-induced inflammation in human articular chondrocytes involved both Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-dependent and -independent signaling pathways.	Resveratrol	73-84	interleukin 1 beta	Homo sapiens	93-115
27669541-0	2017	Sucrose, But Not Glucose, Blocks IL1-beta-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway.	Sucrose	0-7	interleukin 1 beta	Homo sapiens	33-41
28204817-8	2017	Our results revealed that resveratrol prevented the IL-1beta-induced reduction in cell viability.	Resveratrol	26-37	interleukin 1 beta	Homo sapiens	52-60
28204817-10	2017	Correspondingly, IL-1beta-induced catabolic and inflammatory responses were effectively reversed by resveratrol.	Resveratrol	100-111	interleukin 1 beta	Homo sapiens	17-25
27669541-8	2017	Sucrose activated autophagy blocked IL-1beta-induced apoptosis and mRNA expression of MMP-13, COX-2, and IL-6 in human OA chondrocytes.	Sucrose	0-7	interleukin 1 beta	Homo sapiens	36-44
27669541-10	2017	In conclusion, sucrose attenuated IL-1beta induced apoptosis and the expression of catabolic mediators by inducing autophagy, and the autophagy in part was mediated through the activation of AKT/mTOR/P70S6K signaling pathway in human OA chondrocytes.	Sucrose	15-22	interleukin 1 beta	Homo sapiens	34-42
27906549-6	2017	The HFHC meal induced increases in lipopolysaccharide (LPS) concentrations, MNC reactive oxygen species generation, and the expression of interleukin (IL)-1beta, tumor necrosis factor alpha (TNF-alpha), Toll-like receptor (TLR)-4, and CD14.	hfhc	4-8	interleukin 1 beta	Homo sapiens	138-160
28130493-4	2017	MLKL activation triggers potassium efflux and assembly of the NLRP3 inflammasome, which is required for the processing and activity of IL-1beta released during necroptosis.	Potassium	25-34	interleukin 1 beta	Homo sapiens	135-143
28087442-4	2017	Here, we found that the expression levels of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), two key enzymes in the generation of H2S, were significantly decreased in human degenerate NP tissues as well as in IL-1beta-treated NP cells.	Hydrogen Sulfide	153-156	interleukin 1 beta	Homo sapiens	232-240
25414128-3	2017	We found that O-phenanthroline reduced the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFalpha/IL-1beta exposure in an explant model.	1,10-phenanthroline	14-30	interleukin 1 beta	Homo sapiens	176-184
25414128-4	2017	Interestingly, O-phenanthroline significantly inhibited matrix degradation in a TNFalpha/IL-1beta-dependent model of cartilage degeneration when compared to control and natural hypoxia (2.5% O2 ).	1,10-phenanthroline	15-31	interleukin 1 beta	Homo sapiens	89-97
27940204-10	2017	LPS combined with ATP dramatically increased protein synthesis and cleavage of IL-1beta and its mRNA level than those in HSC treated with LPS or ATP alone.	Adenosine Triphosphate	18-21	interleukin 1 beta	Homo sapiens	79-87
27940204-10	2017	LPS combined with ATP dramatically increased protein synthesis and cleavage of IL-1beta and its mRNA level than those in HSC treated with LPS or ATP alone.	Adenosine Triphosphate	145-148	interleukin 1 beta	Homo sapiens	79-87
28230606-8	2017	Preincubation with BCM and LCM for 4 hours significantly prevented the decrease of Caco-2 TER induced by 24 hours of stimulation with 10 ng/mL IL-1beta.	Lincomycin	27-30	interleukin 1 beta	Homo sapiens	143-151
28230606-10	2017	IL-1beta stimulation decreased occludin expression and increased claudin-1 expression in Caco-2 cells (P &lt; 0.05), which was prevented in cells treated with BCM or LCM.	Lincomycin	166-169	interleukin 1 beta	Homo sapiens	0-8
28087442-5	2017	NaHS (H2S donor) administration showed a protective effect by inhibiting the endoplasmic reticulum (ER) stress response and mitochondrial dysfunction induced by IL-1beta stimulation in vitro, the effect was related to activation of the PI3K/Akt and ERK1/2 signaling pathways.	sodium bisulfide	0-4	interleukin 1 beta	Homo sapiens	161-169
28087442-5	2017	NaHS (H2S donor) administration showed a protective effect by inhibiting the endoplasmic reticulum (ER) stress response and mitochondrial dysfunction induced by IL-1beta stimulation in vitro, the effect was related to activation of the PI3K/Akt and ERK1/2 signaling pathways.	Hydrogen Sulfide	6-9	interleukin 1 beta	Homo sapiens	161-169
28087442-8	2017	Taken together, our results suggest that H2S plays a protective role in IVDD and the underlying mechanism involves PI3K/Akt and ERK1/2 signaling pathways-mediated suppression of ER stress and mitochondrial dysfunction in IL-1beta-induced NP cells.	Hydrogen Sulfide	41-44	interleukin 1 beta	Homo sapiens	221-229
28192257-9	2017	Co-treatment with levosimendan strongly attenuated the effects of IL-1beta and thrombin on PAI-1 and TF mRNA by up to 50% and 45%, in a dose- and time-dependent manner.	Simendan	18-30	interleukin 1 beta	Homo sapiens	66-74
28394395-4	2017	The results showed that the induction of the expression of IL1B, IL6 and CXCLi2 by poly I:C, LPS, and CpG-ODN were suppressed by Bay11-7085, but not by tanshinone IIA.	Poly I-C	83-91	interleukin 1 beta	Homo sapiens	59-63
28612530-8	2017	Minocycline significantly decreased the expressions of IL-1beta, IL-6 and A2AR and the number of CD11b-positive cells in peri-infarct region.	Minocycline	0-11	interleukin 1 beta	Homo sapiens	55-63
28017802-3	2017	We present here an Ordinary Differential Equation-based model that investigates the mechanisms of inflammasome activation and regulation in monocytes to predict IL-1beta activation kinetics upon a two-step activation by Damage-Associate-Molecular-Particles (DAMP) and extracellular ATP.	Adenosine Triphosphate	282-285	interleukin 1 beta	Homo sapiens	161-169
28240322-4	2017	Pre-treatment of microglia with 30-60 muM ZnCl2 resulted in dose-dependent increases in interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNFalpha) secretion when M1 activation was induced by lipopolysaccharide administration.	zinc chloride	42-47	interleukin 1 beta	Homo sapiens	88-106
28240322-4	2017	Pre-treatment of microglia with 30-60 muM ZnCl2 resulted in dose-dependent increases in interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNFalpha) secretion when M1 activation was induced by lipopolysaccharide administration.	zinc chloride	42-47	interleukin 1 beta	Homo sapiens	108-116
28251074-8	2017	LPS at concentrations of 300 ng/mL for 1h significantly stimulated the mRNA expression of IL-8, IL-6, IL-1beta, TNF-alpha, and TGF-beta in HCECs, while the stimulation effects were significantly inhibited by AA (20 micromol/L).	Hydrogen	39-41	interleukin 1 beta	Homo sapiens	102-110
28178994-11	2017	RESULTS: Doxycycline decreased plasma lysophosphatidate concentrations, delayed tumor growth and decreased the concentrations of several cytokines/chemokines (IL-1beta, IL-6, IL-9, CCL2, CCL11, CXCL1, CXCL2, CXCL9, G-CSF, LIF, VEGF) in the tumor.	Doxycycline	9-20	interleukin 1 beta	Homo sapiens	159-167
28057759-8	2017	Instead, depletion of cardiolipin synthase 1 abolished abacavir-induced IL-1beta secretion, suggesting that mitochondrial cardiolipin release may trigger abacavir-induced inflammasome activation.	abacavir	55-63	interleukin 1 beta	Homo sapiens	72-80
28057759-8	2017	Instead, depletion of cardiolipin synthase 1 abolished abacavir-induced IL-1beta secretion, suggesting that mitochondrial cardiolipin release may trigger abacavir-induced inflammasome activation.	abacavir	154-162	interleukin 1 beta	Homo sapiens	72-80
28205610-3	2017	CR-LAAO induced acute inflammatory responses in vivo, with recruitment of neutrophils and release of IL-6, IL-1beta, LTB4 and PGE2.	cr-laao	0-7	interleukin 1 beta	Homo sapiens	107-115
28205610-4	2017	In vitro, IL-6 and IL-1beta production by peritoneal macrophages stimulated with CR-LAAO was dependent of the activation of the Toll-like receptors TLR2 and TLR4.	cr-laao	81-88	interleukin 1 beta	Homo sapiens	19-27
28205610-5	2017	In addition, CR-LAAO promoted apoptosis of HL-60 and HepG2 tumor cells mediated by the release of hydrogen peroxide and activation of immune cells, resulting in oxidative stress and production of IL-6 and IL-1beta that triggered a series of events, such as activation of caspase 8, 9 and 3, and the expression of the pro-apoptotic gene BAX.	cr-laao	13-20	interleukin 1 beta	Homo sapiens	205-213
28261091-5	2017	Succinate promoted IL-1beta production through NLRP3 inflammasome activation and then increased cAMP accumulation by impairing PDE3B expression, leading to increased lipolysis.	Succinic Acid	0-9	interleukin 1 beta	Homo sapiens	19-27
28057759-4	2017	We show that abacavir fails to generate direct innate immune activation in human monocytes but potently triggers IL-1beta release upon pro-inflammatory priming with phorbol ester or Toll-like receptor stimulation.	abacavir	13-21	interleukin 1 beta	Homo sapiens	113-121
28057759-4	2017	We show that abacavir fails to generate direct innate immune activation in human monocytes but potently triggers IL-1beta release upon pro-inflammatory priming with phorbol ester or Toll-like receptor stimulation.	Phorbol Esters	165-178	interleukin 1 beta	Homo sapiens	113-121
28057759-5	2017	IL-1beta processing and secretion were sensitive to Caspase-1 inhibition, NLRP3 knockdown, and K+ efflux inhibition and were not observed with other non-allergenic nucleoside reverse transcriptase inhibitors, identifying abacavir as a specific inflammasome activator.	abacavir	221-229	interleukin 1 beta	Homo sapiens	0-8
28088327-9	2017	Thus, IL-1beta c-Src and IL-1beta NOX signaling pathways appear to be responsible for the production of cellular and mitochondrial ROS in CFTR-KD cells.	nicotine 1-N-oxide	34-37	interleukin 1 beta	Homo sapiens	6-14
28088327-9	2017	Thus, IL-1beta c-Src and IL-1beta NOX signaling pathways appear to be responsible for the production of cellular and mitochondrial ROS in CFTR-KD cells.	nicotine 1-N-oxide	34-37	interleukin 1 beta	Homo sapiens	25-33
28088327-9	2017	Thus, IL-1beta c-Src and IL-1beta NOX signaling pathways appear to be responsible for the production of cellular and mitochondrial ROS in CFTR-KD cells.	ros	131-134	interleukin 1 beta	Homo sapiens	6-14
28088327-9	2017	Thus, IL-1beta c-Src and IL-1beta NOX signaling pathways appear to be responsible for the production of cellular and mitochondrial ROS in CFTR-KD cells.	ros	131-134	interleukin 1 beta	Homo sapiens	25-33
28170408-8	2017	Cells treated with TNFalpha and IL-1beta but not LPS for 24 h resulted in a significant (p &lt; 0.001) decrease in the expression of occludin, and the decrease could be partially blocked by SB202190, the inhibitor for p38MAPK.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	190-198	interleukin 1 beta	Homo sapiens	32-40
28223944-7	2017	ERK1/2 inhibition by the specific MEK1/2 inhibitors PD98059/U0126 significantly attenuated the IL-1beta mediated downregulation of PDZK1, while NF-kappaB, p38 MAPK, and JNK inhibition did not.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	52-59	interleukin 1 beta	Homo sapiens	95-103
28223944-7	2017	ERK1/2 inhibition by the specific MEK1/2 inhibitors PD98059/U0126 significantly attenuated the IL-1beta mediated downregulation of PDZK1, while NF-kappaB, p38 MAPK, and JNK inhibition did not.	U 0126	60-65	interleukin 1 beta	Homo sapiens	95-103
28223944-9	2017	Moreover, the RAR/RXR ligand 9-cis retinoic acid and the PPARalpha-agonist GW7647 stimulated PDZK1 mRNA and protein expression and attenuated IL-1beta-mediated inhibition.	Alitretinoin	29-48	interleukin 1 beta	Homo sapiens	142-150
28223944-9	2017	Moreover, the RAR/RXR ligand 9-cis retinoic acid and the PPARalpha-agonist GW7647 stimulated PDZK1 mRNA and protein expression and attenuated IL-1beta-mediated inhibition.	GW 7647	75-81	interleukin 1 beta	Homo sapiens	142-150
27864235-10	2017	NEW &amp; NOTEWORTHY: This study represents the evidence linking L5-LDL and the inflammatory cytokine IL-1beta in ST-segment elevation myocardial infarction (STEMI).	Adenosine Monophosphate	5-8	interleukin 1 beta	Homo sapiens	102-110
27998979-11	2017	Dexamethasone induces the recruitment of ACTN4 and GR to putative GREs in dexamethasone-transactivated promoters, SERPINE1, ANGPLT4, CCL20, and SAA1 as well as the NF-kappaB (p65) binding sites on GR-transrepressed promoters such as IL-1beta, IL-6, and IL-8 Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	233-241
27998979-11	2017	Dexamethasone induces the recruitment of ACTN4 and GR to putative GREs in dexamethasone-transactivated promoters, SERPINE1, ANGPLT4, CCL20, and SAA1 as well as the NF-kappaB (p65) binding sites on GR-transrepressed promoters such as IL-1beta, IL-6, and IL-8 Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.	Dexamethasone	74-87	interleukin 1 beta	Homo sapiens	233-241
28170076-0	2017	Biomimetic sulphated alginate hydrogels suppress IL-1beta-induced inflammatory responses in human chondrocytes.	Alginates	21-29	interleukin 1 beta	Homo sapiens	49-57
28170076-8	2017	The sulphated alginate matrices were found to interact with IL-1beta, and proposed to inhibit inflammatory induction by sequestering cytokines from their receptors.	Alginates	14-22	interleukin 1 beta	Homo sapiens	60-68
27909955-5	2017	We investigated this issue by monitoring the effects of DAB on phorbol-12-myristate 13-acetate (PMA)-, tumor necrosis factor (TNF)-alpha-, interleukin (IL)-1beta-induced EPCR shedding in human umbilical vein endothelial cells (HUVECs), and cecal ligation and puncture (CLP)-mediated EPCR shedding in mice and underlying mechanism.	dabrafenib	56-59	interleukin 1 beta	Homo sapiens	139-161
27834690-4	2017	In experimental atherogenesis, Rac2 prevented progressive calcification through its suppression of Rac1-dependent macrophage interleukin-1beta (IL-1beta) expression, which in turn is a key driver of vascular smooth muscle cell calcium deposition by its ability to promote osteogenic transcriptional programs.	Calcium	227-234	interleukin 1 beta	Homo sapiens	125-142
27802778-7	2017	Transplantation of these cells significantly decreased OVX-induced serum levels of interleukin 6 and interleukin 1 beta, and receptor activator of nuclear factor kappa B gene expression levels in bone tissue.	ovx	55-58	interleukin 1 beta	Homo sapiens	101-169
27834690-4	2017	In experimental atherogenesis, Rac2 prevented progressive calcification through its suppression of Rac1-dependent macrophage interleukin-1beta (IL-1beta) expression, which in turn is a key driver of vascular smooth muscle cell calcium deposition by its ability to promote osteogenic transcriptional programs.	Calcium	227-234	interleukin 1 beta	Homo sapiens	144-152
27834690-5	2017	Calcified coronary arteries from patients revealed decreased Rac2 expression but increased IL-1beta expression, and high coronary calcium burden in patients with coronary artery disease was associated with significantly increased serum IL-1beta levels.	Calcium	130-137	interleukin 1 beta	Homo sapiens	236-244
27834690-6	2017	Moreover, we found that elevated IL-1beta was an independent predictor of cardiovascular death in those subjects with high coronary calcium burden.	Calcium	132-139	interleukin 1 beta	Homo sapiens	33-41
27334433-11	2017	Se-supplementation inhibited expression of pro-inflammatory factors TNF-alpha and IL-1beta and promoted production of anti-inflammatory cytokine IL-10 in the liver with acute alcoholism.	Selenium	0-2	interleukin 1 beta	Homo sapiens	82-90
27339255-12	2017	The pro-inflammatory cytokine interleukin-lbeta (IL-1beta) mRNA expression in the jejunum mucosa was downregulated in the ZnO-supplemented group, compared with the control (P &lt; 0.05).	Zinc Oxide	122-125	interleukin 1 beta	Homo sapiens	49-57
27643869-5	2017	In addition, CsA increased production of inflammatory cytokines, including interleukin (IL)-1beta and IL-6, associated with an increase in nuclear levels of nuclear factor-kappaB (NF-kappaB) which also enhanced vascular permeability.	Cyclosporine	13-16	interleukin 1 beta	Homo sapiens	75-97
27845246-6	2017	Whereas palmitate did not prime the NLRP3 inflammasome, it induced activation in LPS-primed cardiac fibroblasts as indicated by IL-1beta, IL-18 production and NLRP3-ASC co-localization.	Palmitates	8-17	interleukin 1 beta	Homo sapiens	128-136
28168393-9	2017	Further, alcohol-related increases (1.5-3.0 fold) were observed in the expression of hepatic cytokines (TNF-alpha, IL-1 beta, IL-6, IL-10) and other factors noted to be involved in the colonization of CRC cells including ICAM-1, CCL-2, CCL-7, MMP-2, and MMP-9.	Alcohols	9-16	interleukin 1 beta	Homo sapiens	115-124
27863335-9	2017	TAPI-1 significantly inhibited the increase in sIL-6R induced by IL-1beta.	N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide	0-6	interleukin 1 beta	Homo sapiens	65-73
28081450-8	2017	RESULTS: HPA siRNA and heparanase inhibitor sulodexide could attenuate the increasing inflammatory factors (TNF-alpha and IL-1beta) in AGEs-stimulated macrophages.	glucuronyl glucosamine glycan sulfate	44-54	interleukin 1 beta	Homo sapiens	122-130
27185338-5	2017	This study reveals that exposures to DBT (24 h, 48 h and 6 days) modify the secretion of IL-1beta from increasingly reconstituted preparations of human immune cells (highly enriched human natural killer cells, monocyte-depleted [MD] peripheral blood mononuclear cells [PBMCs], PBMCs, granulocytes and a preparation combining both PBMCs and granulocytes).	di-n-butyltin	37-40	interleukin 1 beta	Homo sapiens	89-97
27665119-4	2017	The results showed that the mRNA expression of IL-1beta, IL-6 and TNF-alpha can be down-regulated by pre-treatment of TSA in LPS-stimulated broiler PBMC.	trichostatin A	118-121	interleukin 1 beta	Homo sapiens	47-55
27988459-4	2017	One of these derivatives, (Z)-2-((5-(hydroxymethyl) furan-2-yl) methylene) benzofuran-3(2H)-one (aurone 1), was found to inhibit LPS-induced secretion of the pro-inflammatory cytokines, tumor-necrosis factor alpha (TNFalpha), interleukin 1beta (IL-1beta), and IL-8 by THP-1 cells.	(z)-2-((5-(hydroxymethyl) furan-2-yl) methylene) benzofuran-3(2h)-one	26-95	interleukin 1 beta	Homo sapiens	226-243
27988459-4	2017	One of these derivatives, (Z)-2-((5-(hydroxymethyl) furan-2-yl) methylene) benzofuran-3(2H)-one (aurone 1), was found to inhibit LPS-induced secretion of the pro-inflammatory cytokines, tumor-necrosis factor alpha (TNFalpha), interleukin 1beta (IL-1beta), and IL-8 by THP-1 cells.	(z)-2-((5-(hydroxymethyl) furan-2-yl) methylene) benzofuran-3(2h)-one	26-95	interleukin 1 beta	Homo sapiens	245-253
27185338-11	2017	These results indicate that DBT alters IL-1beta secretion from human immune cells in an ex.	di-n-butyltin	28-31	interleukin 1 beta	Homo sapiens	39-47
27734234-6	2017	MFN inhibited IL-1beta-induced inflammatory mediators PGE2 and NO production.	Dinoprostone	54-58	interleukin 1 beta	Homo sapiens	14-22
27185338-6	2017	DBT altered IL-1beta secretion from all cell preparations.	di-n-butyltin	0-3	interleukin 1 beta	Homo sapiens	12-20
27185338-7	2017	Higher concentrations of DBT (5 and 2.5 mum) decreased the secretion of IL-1beta, while lower concentrations of DBT (0.1 and 0.05 mum) increased the secretion of IL-1beta.	di-n-butyltin	25-28	interleukin 1 beta	Homo sapiens	72-80
27185338-7	2017	Higher concentrations of DBT (5 and 2.5 mum) decreased the secretion of IL-1beta, while lower concentrations of DBT (0.1 and 0.05 mum) increased the secretion of IL-1beta.	di-n-butyltin	112-115	interleukin 1 beta	Homo sapiens	162-170
27185338-8	2017	Selected signaling pathways were examined in MD-PBMCs to determine if they play a role in DBT-induced elevations of IL-1beta secretion.	di-n-butyltin	90-93	interleukin 1 beta	Homo sapiens	116-124
27185338-13	2017	Thus, DBT may have the potential to alter IL-1beta secretion in an in vivo system.	di-n-butyltin	6-9	interleukin 1 beta	Homo sapiens	42-50
28031477-7	2017	In fact, restoration of cholesterol concentrations in cells lacking lipin-2 decreases ion currents through the P2X7 receptor, and downstream events that drive IL-1beta production.	Cholesterol	24-35	interleukin 1 beta	Homo sapiens	159-167
26987886-0	2017	Titanium ions form particles that activate and execute interleukin-1beta release from lipopolysaccharide-primed macrophages.	Titanium	0-8	interleukin 1 beta	Homo sapiens	55-72
28110709-5	2017	Mitochondrial reactive oxygen species in turn activate the NLRP3 inflammasome, allowing increased IL-1beta processing and secretion, which likely underlies both chromium(VI)-induced cutaneous toxicity and sensitization.	Reactive Oxygen Species	14-37	interleukin 1 beta	Homo sapiens	98-106
28110709-6	2017	Interrupting this mechanism, perhaps with reducing agents or inhibitors of the NLRP3/IL-1 axis, may be a new option to prevent occupational chromium toxicity and allergy.	Chromium	140-148	interleukin 1 beta	Homo sapiens	85-89
27082319-12	2017	Harpagoside significantly altered the global chemokine expression profile in IL-1beta-stimulated OA chondrocytes.	harpagoside	0-11	interleukin 1 beta	Homo sapiens	77-85
27082319-13	2017	Expression of IL-6 was highly induced by IL-1beta, which was significantly inhibited by pre-treatment of OA chondrocytes with harpagoside.	harpagoside	126-137	interleukin 1 beta	Homo sapiens	41-49
27082319-14	2017	Harpagoside did not inhibit the IL-1beta-induced activation of NF-kappaB and C/EBPbeta transcription factors but suppressed the IL-1beta-triggered induction, phosphorylation, and DNA binding activity of c-FOS, one of the main components of AP-1 transcription factors.	harpagoside	0-11	interleukin 1 beta	Homo sapiens	128-136
27751866-5	2017	IL-1beta release required priming by phorbol-ester or toll-like receptor stimulation and was prevented by inhibition of K+ efflux, NLRP3 depletion or caspase-1 inhibition, identifying chromium (VI) as a hapten activator of the NLRP3 inflammasome.	Phorbol Esters	37-50	interleukin 1 beta	Homo sapiens	0-8
27751866-7	2017	IL-1beta release further correlated with cytotoxicity that was secondary to reactive oxygen species, K+ efflux, and NLRP3 activation.	Reactive Oxygen Species	76-99	interleukin 1 beta	Homo sapiens	0-8
28000894-0	2017	Berberine affects osteosarcoma via downregulating the caspase-1/IL-1beta signaling axis.	Berberine	0-9	interleukin 1 beta	Homo sapiens	64-72
28000894-8	2017	Furthermore, administration of berberine is capable of reducing the expression of caspase-1 and IL-1beta in osteosarcoma cells and inhibiting the growth of tumor cells.	Berberine	31-40	interleukin 1 beta	Homo sapiens	96-104
28000894-9	2017	Based on the above, for the first time, we propose the hyposis that berberine could gengerate an anti-osteosarcoma property through downregulating caspase-1/IL-1beta inflammatory signaling axis.	Berberine	68-77	interleukin 1 beta	Homo sapiens	157-165
28474063-5	2017	RESULTS: RSV could reverse the increase of TLR4 level in gingival epithelial cells in high glucose medium.LPS markedly increased the expression and secretion of IL-1beta, IL-6, IL-8, and TNF-alpha in GECs cultured in high glucose medium, which was partly blocked in the presence of RSV.	Glucose	222-229	interleukin 1 beta	Homo sapiens	161-169
27418662-14	2017	The high level of Thr inclusion (3 g/kg) upregulated mucin-2 mRNA expression (P = 0.034), whereas downregulated the mRNA abundances of interferon-gamma (P = 0.036) and interleukin-1beta (P = 0.031) in the ileum.	Threonine	18-21	interleukin 1 beta	Homo sapiens	168-185
27736317-6	2017	OACs in coculture with AMs expressed significantly higher levels of MMP-1, MMP-3, MMP-9, MMP-13, IL-1beta, TNF-alpha, IL-6, IL-8, and IFN-gamma compared to OACs in mono-culture, indicating that proinflammatory macrophages may intensify the abnormal matrix degradation and cytokine secretion already associated with OACs.	oacs	0-4	interleukin 1 beta	Homo sapiens	97-105
27596523-6	2017	We also analyzed the effects of CS exposure on the inflammatory response, and observed a significant increase in secretion of IL-8, GRO-alpha, IL-1beta, and GM-CSF.	Cesium	32-34	interleukin 1 beta	Homo sapiens	143-151
27736317-7	2017	Likewise, AMs cocultured with OACs expressed significantly more IL-1beta and VEGF-A compared to AM mono-culture controls, suggesting that OACs may intensify abnormal macrophage activation.	oacs	30-34	interleukin 1 beta	Homo sapiens	64-72
27824294-9	2017	H2O2 determined an increase in endogenous cytokines involved in the response to oxidative stress and GO pathogenesis, namely tumor necrosis factor alpha, interleukin 1 beta, and interferon gamma.	Hydrogen Peroxide	0-4	interleukin 1 beta	Homo sapiens	154-172
27736317-7	2017	Likewise, AMs cocultured with OACs expressed significantly more IL-1beta and VEGF-A compared to AM mono-culture controls, suggesting that OACs may intensify abnormal macrophage activation.	oacs	138-142	interleukin 1 beta	Homo sapiens	64-72
27736317-8	2017	Finally, OACs cultured in the presence of nonactivated macrophages produced lower levels of MMP-9 and proinflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma compared to OACs in the OAC-AM system, results that are consistent with anti-inflammatory agents temporarily reducing certain OA symptoms.	oacs	9-13	interleukin 1 beta	Homo sapiens	128-136
27736317-8	2017	Finally, OACs cultured in the presence of nonactivated macrophages produced lower levels of MMP-9 and proinflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma compared to OACs in the OAC-AM system, results that are consistent with anti-inflammatory agents temporarily reducing certain OA symptoms.	SDZ 33-243	9-12	interleukin 1 beta	Homo sapiens	128-136
28118826-8	2017	Concentrations of NAC &gt;=300 muM inhibited the inflammatory response (release of IL-1beta, IL-8, and TNF-alpha) of human airways induced by the overnight stimulation with LPS, whereas lower concentrations of NAC (&gt;=1 muM) were sufficient to reduce the release of IL-6 elicited by LPS.	Acetylcysteine	18-21	interleukin 1 beta	Homo sapiens	83-91
28009871-10	2017	IL-1beta, IL-6 and TNF-alpha protein expressions were also reduced in TNF-alpha-treated CCD-18Co cells by CP anthocyanins at 20.0 mug ml-1 GAE.	Anthocyanins	109-121	interleukin 1 beta	Homo sapiens	0-8
28007550-9	2017	Transient changes in urothelial ATP and PGE2 release were observed, with significant increase in release of interleukin-6, interleukin-8 and interleukin-1beta from urothelial cells treated with gemcitabine.	gemcitabine	194-205	interleukin 1 beta	Homo sapiens	141-158
28146092-2	2017	Two lead compounds, TBZ-09 and TBZ-21, were identified by antiproduction of IL-1beta.	tbz-09	20-26	interleukin 1 beta	Homo sapiens	76-84
28146092-2	2017	Two lead compounds, TBZ-09 and TBZ-21, were identified by antiproduction of IL-1beta.	tbz-21	31-37	interleukin 1 beta	Homo sapiens	76-84
28120948-7	2017	However, pretreatment with the autophagy inhibitor 3-methyladenine showed the potential in further elevating the apoptosis rate induced by IL-1beta in NP cells.	3-methyladenine	51-66	interleukin 1 beta	Homo sapiens	139-147
28100738-17	2017	We proved that miR-142-3p promoted the IL-1beta-dependent glutamate dysfunction by targeting glutamate-aspartate transporter (GLAST), a crucial glial transporter involved in glutamate homeostasis.	Glutamic Acid	58-67	interleukin 1 beta	Homo sapiens	39-47
28241693-7	2017	After pretreated with various concentrations of Gas6 antibody, silica induced higher expressions of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) in dose-dependent manners at two time points.	Silicon Dioxide	63-69	interleukin 1 beta	Homo sapiens	135-143
28100738-6	2017	We propose miR-142-3p as a molecular mediator of the IL-1beta-dependent downregulation of the glial glutamate-aspartate transporter (GLAST), which causes an enhancement of the glutamatergic transmission in the EAE cerebellum.	mir-142-3p	11-21	interleukin 1 beta	Homo sapiens	53-61
28100738-17	2017	We proved that miR-142-3p promoted the IL-1beta-dependent glutamate dysfunction by targeting glutamate-aspartate transporter (GLAST), a crucial glial transporter involved in glutamate homeostasis.	Glutamic Acid	93-102	interleukin 1 beta	Homo sapiens	39-47
28069066-10	2017	RESULTS: Pretreatment with resveratrol significantly inhibited TNF-alpha-induced ICAM-1, iNOS and IL-1beta mRNA expression in HCAECs.	Resveratrol	27-38	interleukin 1 beta	Homo sapiens	98-106
28068976-0	2017	IL-1beta-induced modulation of gene expression profile in human dermal fibroblasts: the effects of Thai herbal Sahatsatara formula, piperine and gallic acid possessing antioxidant properties.	sahatsatara formula	111-130	interleukin 1 beta	Homo sapiens	0-8
28068976-0	2017	IL-1beta-induced modulation of gene expression profile in human dermal fibroblasts: the effects of Thai herbal Sahatsatara formula, piperine and gallic acid possessing antioxidant properties.	piperine	132-140	interleukin 1 beta	Homo sapiens	0-8
28068976-0	2017	IL-1beta-induced modulation of gene expression profile in human dermal fibroblasts: the effects of Thai herbal Sahatsatara formula, piperine and gallic acid possessing antioxidant properties.	Gallic Acid	145-156	interleukin 1 beta	Homo sapiens	0-8
28068976-5	2017	Moreover, this study also assessed the free radical scavenging activities of STF and its components using DPPH radical scavenging assay and their inhibitory effects on IL-1beta-induced intracellular reactive oxygen species (ROS) formation in primary human dermal fibroblasts (NHDFs) using DCFDA-flow cytometry analysis.	Reactive Oxygen Species	199-222	interleukin 1 beta	Homo sapiens	168-176
28068976-5	2017	Moreover, this study also assessed the free radical scavenging activities of STF and its components using DPPH radical scavenging assay and their inhibitory effects on IL-1beta-induced intracellular reactive oxygen species (ROS) formation in primary human dermal fibroblasts (NHDFs) using DCFDA-flow cytometry analysis.	Reactive Oxygen Species	224-227	interleukin 1 beta	Homo sapiens	168-176
28068976-5	2017	Moreover, this study also assessed the free radical scavenging activities of STF and its components using DPPH radical scavenging assay and their inhibitory effects on IL-1beta-induced intracellular reactive oxygen species (ROS) formation in primary human dermal fibroblasts (NHDFs) using DCFDA-flow cytometry analysis.	nhdfs	276-281	interleukin 1 beta	Homo sapiens	168-176
28068976-5	2017	Moreover, this study also assessed the free radical scavenging activities of STF and its components using DPPH radical scavenging assay and their inhibitory effects on IL-1beta-induced intracellular reactive oxygen species (ROS) formation in primary human dermal fibroblasts (NHDFs) using DCFDA-flow cytometry analysis.	diacetyldichlorofluorescein	289-294	interleukin 1 beta	Homo sapiens	168-176
28068976-8	2017	Our finding discovered that STF and its active compounds (GA and PP) yielded free radical scavenging activities and abilities to inhibit IL-1beta-induced cellular ROS formation in NHDFs.	Stanford cardioplegic solution	28-31	interleukin 1 beta	Homo sapiens	137-145
28068976-8	2017	Our finding discovered that STF and its active compounds (GA and PP) yielded free radical scavenging activities and abilities to inhibit IL-1beta-induced cellular ROS formation in NHDFs.	Gallic Acid	58-60	interleukin 1 beta	Homo sapiens	137-145
28068976-8	2017	Our finding discovered that STF and its active compounds (GA and PP) yielded free radical scavenging activities and abilities to inhibit IL-1beta-induced cellular ROS formation in NHDFs.	Reactive Oxygen Species	163-166	interleukin 1 beta	Homo sapiens	137-145
28068976-8	2017	Our finding discovered that STF and its active compounds (GA and PP) yielded free radical scavenging activities and abilities to inhibit IL-1beta-induced cellular ROS formation in NHDFs.	nhdfs	180-185	interleukin 1 beta	Homo sapiens	137-145
28068976-11	2017	The GO analysis of the target genes showed that all test compounds including indomethacin, STF and its active compounds, can downregulate the genes involved in NF-kB signaling pathway in IL-1beta-treated NHDFs compared to the cells treated with IL-1beta alone.	Indomethacin	77-89	interleukin 1 beta	Homo sapiens	187-195
28068976-11	2017	The GO analysis of the target genes showed that all test compounds including indomethacin, STF and its active compounds, can downregulate the genes involved in NF-kB signaling pathway in IL-1beta-treated NHDFs compared to the cells treated with IL-1beta alone.	Indomethacin	77-89	interleukin 1 beta	Homo sapiens	245-253
27871911-5	2017	In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells.	theaflavin-3,3'-digallate	33-58	interleukin 1 beta	Homo sapiens	116-135
27871911-5	2017	In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	158-183	interleukin 1 beta	Homo sapiens	116-135
27566229-5	2017	Palmitate treatment altered genes of several GPCR signaling pathways including inflammatory pathways with up-regulated IL-1B, SOCS1 and SOCS2 transcript levels.	Palmitates	0-9	interleukin 1 beta	Homo sapiens	119-124
28056977-8	2017	The pro-inflammatory cytokines IL-6 and IL-1beta were greatly decreased in the LPS + Corilagin group both in supernatant and serum (P &lt; 0.01).	corilagin	85-94	interleukin 1 beta	Homo sapiens	40-48
28585206-7	2017	Adipocyte-specific caspase-1 and production of interleukin-1beta (IL-1beta) by macrophages; both adipocyte and macrophage induction by toll like receptor-4 (TLR4) through nuclear factor-kappaB (NF-kappaB) activation; free fatty acid-induced and TLR-mediated activation of c-Jun N-terminal kinase (JNK)-related pro-inflammatory pathways in CD11c+ immune cells; are effective in macrophage accumulation and in the development of adipose tissue inflammation.	Fatty Acids, Nonesterified	217-232	interleukin 1 beta	Homo sapiens	47-64
28585206-7	2017	Adipocyte-specific caspase-1 and production of interleukin-1beta (IL-1beta) by macrophages; both adipocyte and macrophage induction by toll like receptor-4 (TLR4) through nuclear factor-kappaB (NF-kappaB) activation; free fatty acid-induced and TLR-mediated activation of c-Jun N-terminal kinase (JNK)-related pro-inflammatory pathways in CD11c+ immune cells; are effective in macrophage accumulation and in the development of adipose tissue inflammation.	Fatty Acids, Nonesterified	217-232	interleukin 1 beta	Homo sapiens	66-74
29017152-8	2017	In addition, UA significantly upregulated the gene expression of interleukin-1beta and tumor necrosis factor-alpha in a time- and dose-dependent manner.	Uric Acid	13-15	interleukin 1 beta	Homo sapiens	65-114
28849490-3	2017	Differentiated adipocytes were also stimulated at the concentration of IL-1beta 1 ng/ml with addition of Tau-Ribose.	tau-ribose	105-115	interleukin 1 beta	Homo sapiens	71-79
28135700-2	2017	As a response to cholesterol crystal accumulation, the NLRP3 inflammasome is activated to produce IL-1beta which eventually leads to atherosclerotic lesions.	Cholesterol	17-28	interleukin 1 beta	Homo sapiens	98-106
28044937-9	2017	It is found that 75% of patients who had progression of the disease after NACT bear CT genotype of gene IL-1beta associated with a low expression of the cytokine, while the TT genotype, providing a high level of the expression of IL-1beta gene had met only 25% among patients in this group.	nact	74-78	interleukin 1 beta	Homo sapiens	104-112
28296552-5	2017	We found that siRNA-mediated SOCS3 knock-down in human osteoarthritic chondrocytes increased production of IL-1beta-induced prostaglandin E2, cell growth, transcript level and nuclear translocation of cyclin D1.	Dinoprostone	124-140	interleukin 1 beta	Homo sapiens	107-115
28214831-7	2017	SB203580 treatment significantly inhibited IL-1beta-induced an increase in tight junction permeability of Caco-2 cells via repressing the p38/ATF-2 signaling.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	43-51
28054591-1	2017	The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts.	Dinoprostone	66-82	interleukin 1 beta	Homo sapiens	29-46
28054591-1	2017	The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts.	Dinoprostone	66-82	interleukin 1 beta	Homo sapiens	48-56
28054591-1	2017	The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts.	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	29-46
28054591-1	2017	The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts.	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	48-56
28054591-4	2017	In the presence of MAPK inhibitors, IL-1beta-induced COX-2 expression and PGE2 release were both attenuated.	Dinoprostone	74-78	interleukin 1 beta	Homo sapiens	36-44
28054591-11	2017	These observations suggest that JNK1 phosphorylation is necessary for the activation of the MEK/ERK1/2 pathway and the subsequent COX-2 expression for PGE2 release, and p38 independently contributes to the IL-1beta effect in synovial fibroblasts.	Dinoprostone	151-155	interleukin 1 beta	Homo sapiens	206-214
27930985-9	2017	Down-regulation of FGFR1 attenuated the increase in Ras-GTP expression caused by IL-1beta stimulation.	Radium	52-55	interleukin 1 beta	Homo sapiens	81-89
27930985-9	2017	Down-regulation of FGFR1 attenuated the increase in Ras-GTP expression caused by IL-1beta stimulation.	Guanosine Triphosphate	56-59	interleukin 1 beta	Homo sapiens	81-89
27930985-11	2017	Furthermore, Ras inhibitor manumycin A antagonized the decrease in phosphorylation of PI3K and Akt caused by IL-1beta treatment.	manumycin	27-38	interleukin 1 beta	Homo sapiens	109-117
27930985-12	2017	Both Manumycin A and PI3K/Akt agonist FGF-1 attenuated the inhibitory effect of IL-1beta on cell growth.	manumycin	5-16	interleukin 1 beta	Homo sapiens	80-88
28977782-0	2017	Edaravone Attenuates the Proinflammatory Response in Amyloid-beta-Treated Microglia by Inhibiting NLRP3 Inflammasome-Mediated IL-1beta Secretion.	Edaravone	0-9	interleukin 1 beta	Homo sapiens	126-134
28334721-6	2017	RESULTS: MiR-9 inhibited while anti-miR-9 antisense oligonucleotides induced interleukin-1 beta (IL-1beta) and NLRP3 inflammasome activation in all in vitro models.	Oligonucleotides	52-68	interleukin 1 beta	Homo sapiens	77-95
28334721-6	2017	RESULTS: MiR-9 inhibited while anti-miR-9 antisense oligonucleotides induced interleukin-1 beta (IL-1beta) and NLRP3 inflammasome activation in all in vitro models.	Oligonucleotides	52-68	interleukin 1 beta	Homo sapiens	97-105
28738323-5	2017	RESULTS: H2S attenuated FFA-induced cell apoptosis, and reduced the expression of NLRP3, ASC, pro-caspase-1, caspase-1, IL- 1beta, IL-18 and caspase-3.	Hydrogen Sulfide	9-12	interleukin 1 beta	Homo sapiens	120-129
28977782-10	2017	Moreover, EDA obviously attenuated the depolarization of  psim, reduced mitochondria-derived ROS production and increased SOD-2 activity, resulting in the suppression of NLRP3 inflammasome-mediated IL-1beta secretion in Abeta-treated microglia.	Edaravone	10-13	interleukin 1 beta	Homo sapiens	198-206
27863298-0	2017	Butein inhibits IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice.	butein	0-6	interleukin 1 beta	Homo sapiens	16-24
28625129-11	2017	In this study, we found that TA suppressed the inflammation caused by VEGF, TNF-alpha and IL-1beta, and decreased the retinal vascular hyperpermeability.	Triamcinolone Acetonide	29-31	interleukin 1 beta	Homo sapiens	90-98
29259641-0	2017	Icariin Prevents IL-1beta-Induced Apoptosis in Human Nucleus Pulposus via the PI3K/AKT Pathway.	icariin	0-7	interleukin 1 beta	Homo sapiens	17-25
29259641-1	2017	Purpose: To explore the effect and possible mechanism of icariin, a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum that was applied to IL-1beta pretreated human nucleus pulposus (NP) cells.	icariin	57-64	interleukin 1 beta	Homo sapiens	169-177
29259641-6	2017	Results: We found that the damage effects on human nucleus pulposus cells from 20 ng/ml of IL-1beta exposure were attenuated by icariin.	icariin	128-135	interleukin 1 beta	Homo sapiens	91-99
27833011-6	2017	Ribavirin treatment of uninfected larvae reduces the basal level of IFNgamma, but increases the level of IL-1beta mRNA expression.	Ribavirin	0-9	interleukin 1 beta	Homo sapiens	105-113
27404795-0	2017	Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.	Vorinostat	30-40	interleukin 1 beta	Homo sapiens	91-99
27404795-0	2017	Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.	Vorinostat	42-46	interleukin 1 beta	Homo sapiens	91-99
27404795-0	2017	Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.	Vorinostat	48-54	interleukin 1 beta	Homo sapiens	91-99
28652539-1	2017	In the current study, we examined the effects of LPS and inflammatory cytokines including IL-1beta, TNF-alpha, and IL-6 on the expression of ghrelin in MGN3-1 cells.	Ghrelin	141-148	interleukin 1 beta	Homo sapiens	90-98
29721026-8	2017	Preincubation of ozone at 50 mug/ml decreases IL-8, IL-6, and IL-1beta production by 50, 56, and 70%, respectively, compared to untreated cells.	Ozone	17-22	interleukin 1 beta	Homo sapiens	62-70
27863298-10	2017	We found that butein significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, TNF-alpha, IL-6 and MMP-13, degradation of COL-2 and SOX-9 at mRNA and protein levels as well as MMP-1, MMP-3, ADAMTS-4 and ADAMTS-5 gene expression.	butein	14-20	interleukin 1 beta	Homo sapiens	49-57
27863298-10	2017	We found that butein significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, TNF-alpha, IL-6 and MMP-13, degradation of COL-2 and SOX-9 at mRNA and protein levels as well as MMP-1, MMP-3, ADAMTS-4 and ADAMTS-5 gene expression.	Dinoprostone	87-91	interleukin 1 beta	Homo sapiens	49-57
27863298-11	2017	Furthermore, butein dramatically suppressed IL-1beta-stimulated IkappaB-alpha degradation and NF-kB p65 activation.	butein	13-19	interleukin 1 beta	Homo sapiens	44-52
27903743-0	2017	Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction.	Uric Acid	0-9	interleukin 1 beta	Homo sapiens	87-91
28164132-8	2017	High glucose induced a significant increase in NLRP3 inflammasome and IL-1beta expression in THP-1-derived macrophages.	Glucose	5-12	interleukin 1 beta	Homo sapiens	70-78
28164132-12	2017	The higher expression of NLRP3, caspase1, and secretion of IL-1beta, signaling, and activation might contribute to the hyperinflammation in the human diabetic wound and in high glucose induced macrophages.	Glucose	177-184	interleukin 1 beta	Homo sapiens	59-67
27876507-8	2017	While exercise did not affect pro-inflammatory cytokines in serum, in sWBC only IL-1beta was increased 1.2-fold at 3h (p&lt;0,05).	Tritium	115-117	interleukin 1 beta	Homo sapiens	80-88
27619557-8	2017	We found that PA-treated skeletal muscle cells actively secreted interleukin-1beta (IL-1beta) and augmented the migration, proliferation and expression of fibronectin in L929 fibroblasts.	Palmitic Acid	14-16	interleukin 1 beta	Homo sapiens	65-82
27619557-8	2017	We found that PA-treated skeletal muscle cells actively secreted interleukin-1beta (IL-1beta) and augmented the migration, proliferation and expression of fibronectin in L929 fibroblasts.	Palmitic Acid	14-16	interleukin 1 beta	Homo sapiens	84-92
28115138-5	2017	Here, we indicated that endogenous 2-AG protected against neuroinflammation in response to SO2 inhalation by inhibiting the activation of microglia and astrocytes and attenuating the overexpression of inflammatory cytokines, including tumor necrosis factor alpha (TNF-a), interleukin (IL)-1beta, and inducible nitric oxide synthase (iNOS).	glyceryl 2-arachidonate	35-39	interleukin 1 beta	Homo sapiens	272-294
27655219-4	2017	Both hemin and its derivative, cobalt protoporphyrin (CoPP), significantly reduced IL-1beta secretion by cultured human primary macrophages, the human monocytic leukemia cell line and also mouse bone marrow-derived and peritoneal macrophages.	Hemin	5-10	interleukin 1 beta	Homo sapiens	83-91
27903743-6	2017	We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants.	Uric Acid	14-23	interleukin 1 beta	Homo sapiens	169-177
27655219-4	2017	Both hemin and its derivative, cobalt protoporphyrin (CoPP), significantly reduced IL-1beta secretion by cultured human primary macrophages, the human monocytic leukemia cell line and also mouse bone marrow-derived and peritoneal macrophages.	cobaltiprotoporphyrin	31-52	interleukin 1 beta	Homo sapiens	83-91
27655219-4	2017	Both hemin and its derivative, cobalt protoporphyrin (CoPP), significantly reduced IL-1beta secretion by cultured human primary macrophages, the human monocytic leukemia cell line and also mouse bone marrow-derived and peritoneal macrophages.	cobaltiprotoporphyrin	54-58	interleukin 1 beta	Homo sapiens	83-91
27903743-6	2017	We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants.	Uric Acid	25-41	interleukin 1 beta	Homo sapiens	169-177
27903743-6	2017	We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants.	Uric Acid	43-46	interleukin 1 beta	Homo sapiens	169-177
28286378-6	2017	Iron significantly reduced mRNA levels of IL-6, IL-1beta, TNF-alpha, and iNOS produced by IFN-gamma-polarized M1 macrophages.	Iron	0-4	interleukin 1 beta	Homo sapiens	48-56
26911385-11	2017	Free donepezil and donepezil loaded nanoparticle administration caused a significant dose-dependent decrease in both gene and protein expression levels of IL-1beta, IL-6, GM-CSF and TNF-alpha.	Donepezil	5-14	interleukin 1 beta	Homo sapiens	155-163
26911385-11	2017	Free donepezil and donepezil loaded nanoparticle administration caused a significant dose-dependent decrease in both gene and protein expression levels of IL-1beta, IL-6, GM-CSF and TNF-alpha.	Donepezil	19-28	interleukin 1 beta	Homo sapiens	155-163
27541080-5	2017	METHODS: Through RNA interference or pharmacologic inhibition using AT1R antagonist losartan, HGF and HPLF were stimulated by IL-1beta for 3 (messenger RNA [mRNA]) or 24 (protein) hours.	Losartan	84-92	interleukin 1 beta	Homo sapiens	126-134
28757683-0	2017	Chemokines (CCL3, CCL4, and CCL5) Inhibit ATP-Induced Release of IL-1beta by Monocytic Cells.	Adenosine Triphosphate	42-45	interleukin 1 beta	Homo sapiens	65-73
28588350-5	2017	Exposure of retinal neural cell cultures to high glucose upregulated both mRNA and protein levels of IL-1beta.	Glucose	49-56	interleukin 1 beta	Homo sapiens	101-109
28740332-4	2017	Glibenclamide might block KATP channel, Sur1-Trpm4 channel, and NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome activation, decrease the production of proinflammatory mediators (TNF-alpha, IL-1beta, and reactive oxygen species), and suppress the accumulation of inflammatory cells.	Glyburide	0-13	interleukin 1 beta	Homo sapiens	206-214
28757683-5	2017	Here, we hypothesize that chemokines control ATP-dependent secretion of monocytic IL-1beta.	Adenosine Triphosphate	45-48	interleukin 1 beta	Homo sapiens	82-90
28757683-6	2017	Lipopolysaccharide-primed human monocytic U937 cells were stimulated with the P2X7 agonist BzATP for 30 min to induce IL-1beta release.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	91-96	interleukin 1 beta	Homo sapiens	118-126
28757683-7	2017	CCL3, CCL4, and CCL5 dose dependently inhibited BzATP-stimulated release of IL-1beta, whereas CXCL16 was ineffective.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	48-53	interleukin 1 beta	Homo sapiens	76-84
28757683-11	2017	We suggest that CCL chemokines inhibit ATP-induced release of IL-1beta from U937 cells by a triple-membrane-passing mechanism involving CCR, iPLA2, release of small mediators, and nicotinic acetylcholine receptor subunits alpha7 and alpha9.	Cefaclor	16-19	interleukin 1 beta	Homo sapiens	62-70
28757683-11	2017	We suggest that CCL chemokines inhibit ATP-induced release of IL-1beta from U937 cells by a triple-membrane-passing mechanism involving CCR, iPLA2, release of small mediators, and nicotinic acetylcholine receptor subunits alpha7 and alpha9.	Adenosine Triphosphate	39-42	interleukin 1 beta	Homo sapiens	62-70
29249869-7	2017	The patients with POCD had higher serum interleukin 1beta (IL-1beta), serum amyloid A (SAA), S100 calcium-binding protein beta (S-100beta), and high mobility group box-1 protein (HMGB-1) levels at 1 and 24 h postoperatively than patients without POCD.	pocd	18-22	interleukin 1 beta	Homo sapiens	40-57
28757683-12	2017	We speculate that whenever chemokines and ATP enter the circulation concomitantly, systemic release of IL-1beta is minimized.	Adenosine Triphosphate	42-45	interleukin 1 beta	Homo sapiens	103-111
29249869-7	2017	The patients with POCD had higher serum interleukin 1beta (IL-1beta), serum amyloid A (SAA), S100 calcium-binding protein beta (S-100beta), and high mobility group box-1 protein (HMGB-1) levels at 1 and 24 h postoperatively than patients without POCD.	pocd	18-22	interleukin 1 beta	Homo sapiens	59-67
29249869-8	2017	There was an association between POCD and the maximum IL-1beta and S-100beta concentrations in serum, which remained following adjustment for age and FBS.	pocd	33-37	interleukin 1 beta	Homo sapiens	54-62
29166835-7	2017	Finally, we found that cytokine TNF-alpha and IL-1beta increases mediated the STAT3 activation following oxaliplatin treatment.	Oxaliplatin	105-116	interleukin 1 beta	Homo sapiens	46-54
29166835-8	2017	Taken together, these findings suggested that the upregulation of CXCL12 via TNF-alpha/IL-1beta-dependent STAT3 activation contributes to oxaliplatin-induced chronic pain.	Oxaliplatin	138-149	interleukin 1 beta	Homo sapiens	87-95
27106168-6	2017	Similarly, ketamine did not appreciably influence the stressor induced neurochemical and sucrose preference alterations, it did however, dose-dependently reverse the LPS induced elevation of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	Ketamine	11-19	interleukin 1 beta	Homo sapiens	223-240
27245499-6	2017	The kynurenine pathway is also critically regulated by cytokines, and, indeed, the pro-inflammatory cytokines interleukin (IL)-1beta and IL-6 are elevated in schizophrenia and bipolar disorder and stimulate the production of kynurenic acid.	Kynurenine	4-14	interleukin 1 beta	Homo sapiens	110-132
27106168-6	2017	Similarly, ketamine did not appreciably influence the stressor induced neurochemical and sucrose preference alterations, it did however, dose-dependently reverse the LPS induced elevation of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	Ketamine	11-19	interleukin 1 beta	Homo sapiens	242-250
27245499-6	2017	The kynurenine pathway is also critically regulated by cytokines, and, indeed, the pro-inflammatory cytokines interleukin (IL)-1beta and IL-6 are elevated in schizophrenia and bipolar disorder and stimulate the production of kynurenic acid.	Kynurenic Acid	225-239	interleukin 1 beta	Homo sapiens	110-132
27984197-5	2017	The results indicated that chronic nicotine administration (0.1mg/kg, s.c., 14days) inhibited the LPS-induced nuclear binding of NF-kappaB and mRNA expression levels of Tnf, Il1b, Nos2, and Tlr4.	Nicotine	35-43	interleukin 1 beta	Homo sapiens	174-178
27245499-8	2017	This glial signaling pathway initiates a caspase-8-driven activation of IL-1beta that induces tryptophan-2,3-dioxygenase 2 (TDO2), an enzyme in the kynurenine pathway.	Kynurenine	148-158	interleukin 1 beta	Homo sapiens	72-80
29510394-2	2017	Compared to controls, non-stimulated PBMC from the IBSN group produced a significantly lower level of IL-1ra (by 38%; p &lt; 0.001) and significantly lower levels of TNFalpha, IL-1beta, and IFNgamma (by 36% [p &lt; 0.001], 25% [p = 0.06], and 32% [p &lt; 0.02]) under PBMC stimulation.	PBMC	37-41	interleukin 1 beta	Homo sapiens	176-184
28243360-10	2017	Accordingly, polyphenols decreased IL-1beta and IL-6 release in comparison to H controls.	Polyphenols	13-24	interleukin 1 beta	Homo sapiens	35-43
27614315-7	2017	However, primed with LPS, HA fragments produced large dose-dependent increases in IL-1beta that were inhibitable by CS.	Chondroitin Sulfates	116-118	interleukin 1 beta	Homo sapiens	82-90
28265338-5	2017	Furthermore, propolis significantly reduced the H2O2-generated reactive oxygen species (ROS) derived from mitochondria and 8-oxo-2"-deoxyguanosine (8-oxo-dG, the DNA oxidative damage marker) but significantly reversed the fibrillar beta-amyloid and IL-1beta-impaired BDNF-induced Arc expression in SH-SY5Y cells.	Hydrogen Peroxide	48-52	interleukin 1 beta	Homo sapiens	249-257
27373854-8	2017	In pulmonary artery smooth muscle cell (PASMC) suppression of BMP, induction of 5-HT and IL-1 signalling have been shown to stimulate the release of OPG in vitro, which causes cell migration and proliferation.	pasmc	40-45	interleukin 1 beta	Homo sapiens	89-93
29225725-3	2017	Monocytes from both patients and controls only produced a significant increase in IL-1beta in low-glucose conditions (p &lt; 0.01), and this phenomenon was amplified in the presence of LPS, while it was not seen in normal- or high-glucose conditions, not even in the presence of LPS stimulation.	Glucose	98-105	interleukin 1 beta	Homo sapiens	82-90
29911779-4	2017	The expression of IL-1beta, caspase-1 in the supernatant and the expression of pro-caspase-1, pro-IL-1beta, ASC, NLRP3 in cell was detected by Western blot for the inhibitory effect of deoxyschizandrin (25, 50, 100 and 200 mumol L(-1)) on the activity of NLRP3 inflammasome.	schizandrin A	185-201	interleukin 1 beta	Homo sapiens	94-106
28217046-7	2017	Furthermore, TNF-alpha, IL-1beta, and IL-6 were significantly reduced after budesonide nebulizations.	Budesonide	76-86	interleukin 1 beta	Homo sapiens	24-32
28217046-9	2017	CONCLUSION: Nebulized budesonide improved oxygenation, peak, and plateau airway pressures and significantly reduced inflammatory markers (TNF-alpha, IL-1beta and IL-6) without affecting hemodynamics.	Budesonide	22-32	interleukin 1 beta	Homo sapiens	149-157
28713086-25	2017	CONCLUSION: All this made it possible to draw the conclusion that usage of fenspirid hydrochloride hydrochloride in addition to complex therapy essentially reduces the level of IL-1beta in blood serum in compereson to the cases when only basic remedy was used, favours reduction of cases and intensity of systemic inflammations associated with increasing the duration of remission within this type/constellation of patients.	fenspirid hydrochloride hydrochloride	75-112	interleukin 1 beta	Homo sapiens	177-185
27497891-9	2017	Similarly there was a significant increase in the level of both ENA-78 (3.68-fold, p=.02) and IL-1beta (2.11-fold, p=.01) in IVDs with type II MCs.	mcs	143-146	interleukin 1 beta	Homo sapiens	94-102
27497891-11	2017	CONCLUSION: Intervertebral discs with type II MCs demonstrate a significant increase in IL-1beta, GM-CSF, and ENA-78, and there is a trend toward an increase in TNF-alpha.	mcs	46-49	interleukin 1 beta	Homo sapiens	88-96
29911779-7	2017	Deoxyschizandrin (25, 50, 100, and 200 mumol L(-1)) could inhibit the activation of NLRP3 inflammasome caused by nigericin and ATP, and inhibit the secretion of IL-1beta, which was associated with inhibiting the cleavage of pro-caspase-1.	schizandrin A	0-16	interleukin 1 beta	Homo sapiens	161-169
28002421-2	2016	The aims of present study were to investigate the effects of baicalin on the myofibroblast differentiation, extracellular matrix production, migration, and collagen contraction of interleukin (IL)-1beta-stimulated nasal fibroblasts and to determine the molecular mechanism of baicalin in nasal fibroblasts.	baicalin	61-69	interleukin 1 beta	Homo sapiens	180-202
28002421-12	2016	Migration, collagen production, and contraction of IL-1beta-stimulated nasal fibroblasts were significantly inhibited by baicalin treatment.	baicalin	121-129	interleukin 1 beta	Homo sapiens	51-59
28018220-4	2016	Methods and Results: In cultured HASMC, the expression of inducible nitric oxide synthase (iNOS) and the release of nitric oxide were stimulated by both Ang II and IL-1beta, as determined by Western blot and indirect immunofluorescence or the Griess method, respectively.	hasmc	33-38	interleukin 1 beta	Homo sapiens	164-172
28058015-8	2016	RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression.	Vitamin D	28-37	interleukin 1 beta	Homo sapiens	332-340
28058015-9	2016	Thus, active vitamin D may enhance autophagy but suppress inflammatory IL-1beta expression in Salmonella-infected IECs.	Vitamin D	13-22	interleukin 1 beta	Homo sapiens	71-79
28018220-4	2016	Methods and Results: In cultured HASMC, the expression of inducible nitric oxide synthase (iNOS) and the release of nitric oxide were stimulated by both Ang II and IL-1beta, as determined by Western blot and indirect immunofluorescence or the Griess method, respectively.	Nitric Oxide	68-80	interleukin 1 beta	Homo sapiens	164-172
27863411-0	2016	Sesamin inhibits IL-1beta-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway.	sesamin	0-7	interleukin 1 beta	Homo sapiens	17-25
27863411-2	2016	In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1beta-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism.	sesamin	61-68	interleukin 1 beta	Homo sapiens	72-80
27863411-3	2016	Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1beta.	sesamin	26-33	interleukin 1 beta	Homo sapiens	102-110
27863411-3	2016	Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1beta.	Dinoprostone	68-72	interleukin 1 beta	Homo sapiens	102-110
27863411-4	2016	Sesamin inhibited MMP1, MMP3, and MMP13 production in IL-1beta-stimulated chondrocytes.	sesamin	0-7	interleukin 1 beta	Homo sapiens	54-62
27863411-5	2016	Sesamin also inhibited IL-1beta-induced phosphorylation of NF-kappaB p65 and IkappaBalpha.	sesamin	0-7	interleukin 1 beta	Homo sapiens	23-31
27863411-8	2016	In conclusion, our results suggested that sesamin showed anti-inflammatory effects in IL-1beta-stimulated chondrocytes by activating Nrf2 signaling pathway.	sesamin	42-49	interleukin 1 beta	Homo sapiens	86-94
27973447-5	2016	We found that 1,25(OH)2D3 significantly reduced pro-inflammatory cytokines TNF-alpha, IFN-gamma, and IL-1beta as well as the chemokine IL-8 for both ligands (three- to 53-fold), while anti-inflammatory IL-10 was increased (two-fold, p = 0.016) in HK19F-stimulated monocytes.	Calcitriol	14-25	interleukin 1 beta	Homo sapiens	101-109
27980405-7	2016	Interleukin (IL)-1beta, IL-6, and transforming growth factor-beta expression decreased significantly in the PCL group compared with the control.	polycaprolactone	108-111	interleukin 1 beta	Homo sapiens	0-22
27803035-9	2016	In addition, aldosterone increased the expression of NLRP3, active caspase-1, and mature interleukin-1beta in human peripheral blood mononuclear cells.	Aldosterone	13-24	interleukin 1 beta	Homo sapiens	89-106
27510652-0	2016	Interleukin-1beta effect on the endogenous ADP-ribosylation and phosphorylation of eukaryotic elongation factor 2.	Adenosine Diphosphate	43-46	interleukin 1 beta	Homo sapiens	0-17
27833015-6	2016	Our data showed that TMAO significantly triggered oxidative stress and activated TXNIP-NLRP3 inflammasome whereat inflammatory cytokines interleukin (IL)-1beta and IL-18 were released in a dose- and time-dependent manner, but endothelial nitric oxide synthase (eNOS) and production of nitric oxide (NO) were inhibited.	trimethyloxamine	21-25	interleukin 1 beta	Homo sapiens	137-159
27885831-8	2016	To further enhance the system, the electrospun component is loaded with dexamethasone, which protected the cells from an IL-1beta-mediated inflammatory insult.	Dexamethasone	72-85	interleukin 1 beta	Homo sapiens	121-129
27989874-9	2016	RESULTS: Ingestion of DT suppressed CD4+ T cell expression of IL-1beta and Il-8 (p&lt;0.05) and up-regulated the expression of IL-10 and the Treg/IL-17 ratio (p&lt;0.05) which was not shown in PL.	Thymidine	22-24	interleukin 1 beta	Homo sapiens	62-70
27931833-4	2016	In addition, poorly regulated glucose metabolism in diabetic patients is often found with increased levels of chronic inflammatory markers, e.g., interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha, and emerging evidence has highlighted activation of the immune response in the progression and development of cancer cells.	Glucose	30-37	interleukin 1 beta	Homo sapiens	146-168
27745982-10	2016	CONCLUSIONS: The treatment of HNC patients with concurrent CTRT induces a significant increase in the salivary levels of IL-1beta, IL-6, and tumor necrosis factor-alpha, all positively associated with the severity of mucosal toxicity.	ctrt	59-63	interleukin 1 beta	Homo sapiens	121-129
27693323-6	2016	Lipopolysaccharide and adenosine triphosphate stimulation of macrophages from Il10rb-/- mice or IL10R-deficient patients resulted in increased production of IL1beta.	Adenosine Triphosphate	23-45	interleukin 1 beta	Homo sapiens	157-164
28318158-8	2016	2) Compared with H2O2 group, CGRP+H2O2 group significantly increased the SOD activity (P&lt;0.01), ROS content significantly decreased (P&lt;0.01), TNF-alpha, IL-1beta, and IL-6 secretion significantly decreased (P&lt;0.05).	Hydrogen Peroxide	34-38	interleukin 1 beta	Homo sapiens	159-167
26801986-11	2016	We found that thymol and carvacrol protected against APAP-induced toxicity in HepG2 cells by increasing antioxidant activity and reducing pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin 1beta.	carvacrol	25-34	interleukin 1 beta	Homo sapiens	206-223
26801986-11	2016	We found that thymol and carvacrol protected against APAP-induced toxicity in HepG2 cells by increasing antioxidant activity and reducing pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin 1beta.	Acetaminophen	53-57	interleukin 1 beta	Homo sapiens	206-223
27748636-8	2016	However twelve genes were were differently regulated by the two compounds: interleukins (IL) IL-1B, IL-6 and a chemokine CCL22 were upregulated by HIX and significantly supressed by Leflunomide.	hix	147-150	interleukin 1 beta	Homo sapiens	93-98
27748636-8	2016	However twelve genes were were differently regulated by the two compounds: interleukins (IL) IL-1B, IL-6 and a chemokine CCL22 were upregulated by HIX and significantly supressed by Leflunomide.	Leflunomide	182-193	interleukin 1 beta	Homo sapiens	93-98
27761693-12	2016	CONCLUSION: It may be concluded that on chronic administration, CL suppresses inflammation and brings clinical improvement in patients of KOA, which may be observed by decreased level of IL-1beta and VAS/WOMAC scores, respectively.	koa	138-141	interleukin 1 beta	Homo sapiens	187-195
27515563-5	2016	Here, we showed that EGCG inhibits COX-2 mRNA/protein expression or prostaglandin E2 (PGE2 ) production via up-regulating microRNA hsa-miR-199a-3p expression in interleukin (IL)-1beta-stimulated human OA chondrocytes.	epigallocatechin gallate	21-25	interleukin 1 beta	Homo sapiens	161-183
27515563-5	2016	Here, we showed that EGCG inhibits COX-2 mRNA/protein expression or prostaglandin E2 (PGE2 ) production via up-regulating microRNA hsa-miR-199a-3p expression in interleukin (IL)-1beta-stimulated human OA chondrocytes.	Dinoprostone	68-84	interleukin 1 beta	Homo sapiens	161-183
27515563-9	2016	EGCG treatment consistently up-regulated the IL-1beta-decreased hsa-miR-199a-3p expression (P &lt; 0.05) and significantly inhibited the IL-1beta-induced COX-2 expression/PGE2 production (P &lt; 0.05) in OA chondrocytes transfected with anti-hsa-miR-199a-3p.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	45-53
27515563-9	2016	EGCG treatment consistently up-regulated the IL-1beta-decreased hsa-miR-199a-3p expression (P &lt; 0.05) and significantly inhibited the IL-1beta-induced COX-2 expression/PGE2 production (P &lt; 0.05) in OA chondrocytes transfected with anti-hsa-miR-199a-3p.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	137-145
27150261-3	2016	The aim of these studies was to evaluate the pharmacokinetics of ABT-981, a dual variable domain immunoglobulin (DVD-Ig) capable of simultaneously binding IL-1alpha and IL-1beta, in healthy subjects and patients with osteoarthritis of the knee.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	65-68	interleukin 1 beta	Homo sapiens	169-177
27515563-9	2016	EGCG treatment consistently up-regulated the IL-1beta-decreased hsa-miR-199a-3p expression (P &lt; 0.05) and significantly inhibited the IL-1beta-induced COX-2 expression/PGE2 production (P &lt; 0.05) in OA chondrocytes transfected with anti-hsa-miR-199a-3p.	Dinoprostone	171-175	interleukin 1 beta	Homo sapiens	45-53
27515563-9	2016	EGCG treatment consistently up-regulated the IL-1beta-decreased hsa-miR-199a-3p expression (P &lt; 0.05) and significantly inhibited the IL-1beta-induced COX-2 expression/PGE2 production (P &lt; 0.05) in OA chondrocytes transfected with anti-hsa-miR-199a-3p.	Dinoprostone	171-175	interleukin 1 beta	Homo sapiens	137-145
27515563-11	2016	These novel pharmacological actions of EGCG on IL-1beta-stimulated human OA chondrocytes provide new suggestions that EGCG or EGCG-derived compounds inhibit cartilage breakdown or pain by up-regulating the expression of microRNAs in human chondrocytes.	epigallocatechin gallate	39-43	interleukin 1 beta	Homo sapiens	47-55
27515563-11	2016	These novel pharmacological actions of EGCG on IL-1beta-stimulated human OA chondrocytes provide new suggestions that EGCG or EGCG-derived compounds inhibit cartilage breakdown or pain by up-regulating the expression of microRNAs in human chondrocytes.	epigallocatechin gallate	118-122	interleukin 1 beta	Homo sapiens	47-55
27515563-11	2016	These novel pharmacological actions of EGCG on IL-1beta-stimulated human OA chondrocytes provide new suggestions that EGCG or EGCG-derived compounds inhibit cartilage breakdown or pain by up-regulating the expression of microRNAs in human chondrocytes.	epigallocatechin gallate	118-122	interleukin 1 beta	Homo sapiens	47-55
27452044-0	2016	alpha-Linoleic acid enhances the capacity of alpha-1 antitrypsin to inhibit lipopolysaccharide induced IL-1beta in human blood neutrophils.	Linoleic Acid	0-19	interleukin 1 beta	Homo sapiens	103-111
27541079-6	2016	Salivary IL-1beta concentrations were significantly higher in patients with GP than in patients with LP, whereas no difference was found between LP and control groups.	leucylproline	101-103	interleukin 1 beta	Homo sapiens	9-17
27452044-8	2016	Increased gene expression of PPAR-gamma was observed in A1AT-LA treated neutrophils without of LPS stimulation, and the selective PPAR-gamma antagonist (GW9662) prevented the reduction in IL-1beta by A1AT-LA.	2-chloro-5-nitrobenzanilide	153-159	interleukin 1 beta	Homo sapiens	188-196
27889107-6	2016	However, supplementing adipocytes with an equal combination of malvidin plus peonidin followed by LPS treatment decreased the mRNA levels of interleukin (IL)-6, IL-1beta, IL-8, monocyte chemoattractant protein-1, toll-like receptor-2, tumor necrosis factor alpha, cyclooxygenase-2, and interferon gamma-induced protein-10.	peonidin	77-85	interleukin 1 beta	Homo sapiens	161-169
27506813-7	2016	TLR4 were responsible for morphine-induced IL-1beta synthesis, while morphine-induced IL-1beta release was via P2X4R.	Morphine	69-77	interleukin 1 beta	Homo sapiens	86-94
27816506-2	2016	The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes.	Flavonoids	46-56	interleukin 1 beta	Homo sapiens	294-302
27816506-2	2016	The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes.	Phytosterols	77-89	interleukin 1 beta	Homo sapiens	294-302
27506813-0	2016	Morphine enhances IL-1beta release through toll-like receptor 4-mediated endocytic pathway in microglia.	Morphine	0-8	interleukin 1 beta	Homo sapiens	18-26
27506813-1	2016	Morphine creates a neuroinflammatory response and enhances release of the proinflammatory cytokines like interleukin-1beta (IL-1beta), which compromises morphine analgesia as well as induces morphine tolerance.	Morphine	0-8	interleukin 1 beta	Homo sapiens	105-122
27506813-1	2016	Morphine creates a neuroinflammatory response and enhances release of the proinflammatory cytokines like interleukin-1beta (IL-1beta), which compromises morphine analgesia as well as induces morphine tolerance.	Morphine	0-8	interleukin 1 beta	Homo sapiens	124-132
27619532-6	2016	Four aPDT studies showed significant reduction in IL-1beta while one study showed significant reduction in TNF-alpha levels after aPDT application at follow-up.	apdt	5-9	interleukin 1 beta	Homo sapiens	50-58
27506813-1	2016	Morphine creates a neuroinflammatory response and enhances release of the proinflammatory cytokines like interleukin-1beta (IL-1beta), which compromises morphine analgesia as well as induces morphine tolerance.	Morphine	153-161	interleukin 1 beta	Homo sapiens	105-122
27506813-8	2016	Morphine-induced IL-1beta release is mediated by endocytosis of TLR4.	Morphine	0-8	interleukin 1 beta	Homo sapiens	17-25
27506813-1	2016	Morphine creates a neuroinflammatory response and enhances release of the proinflammatory cytokines like interleukin-1beta (IL-1beta), which compromises morphine analgesia as well as induces morphine tolerance.	Morphine	153-161	interleukin 1 beta	Homo sapiens	124-132
27506813-9	2016	These results indicated that TLR4 and P2X4R pathways mediated IL-1beta synthesis and release in microglia followed chronic morphine.	Morphine	123-131	interleukin 1 beta	Homo sapiens	62-70
27506813-1	2016	Morphine creates a neuroinflammatory response and enhances release of the proinflammatory cytokines like interleukin-1beta (IL-1beta), which compromises morphine analgesia as well as induces morphine tolerance.	Morphine	191-199	interleukin 1 beta	Homo sapiens	105-122
27869103-4	2016	Moreover, the thoracic CT-scan score of ILD was significantly associated with the EBC levels of IL-1 beta and with the serum IL-23, TNF-alpha and IL-10 levels, whereas lung carbon monoxide diffusing capacity was negatively related to the EBC levels of IL-1 beta, IL-17 and serum IL-10.	NSC638702	82-85	interleukin 1 beta	Homo sapiens	96-105
27506813-1	2016	Morphine creates a neuroinflammatory response and enhances release of the proinflammatory cytokines like interleukin-1beta (IL-1beta), which compromises morphine analgesia as well as induces morphine tolerance.	Morphine	191-199	interleukin 1 beta	Homo sapiens	124-132
27506813-2	2016	In this study, we attempted to investigate the mechanisms of morphine induced IL-1beta synthesis and release.	Morphine	61-69	interleukin 1 beta	Homo sapiens	78-86
27506813-6	2016	Morphine enhanced IL-1beta synthesis and P2X4R protein expression.	Morphine	0-8	interleukin 1 beta	Homo sapiens	18-26
27506813-7	2016	TLR4 were responsible for morphine-induced IL-1beta synthesis, while morphine-induced IL-1beta release was via P2X4R.	Morphine	26-34	interleukin 1 beta	Homo sapiens	43-51
27435790-8	2016	There was also a statistically significant correlation between the individual values of the plasma 8-OHdG (POP2) versus IL-1beta (POP2) for the MC and LC patients (r = 0.25, p = 0.01).	Methylcholanthrene	144-146	interleukin 1 beta	Homo sapiens	120-128
27435790-10	2016	A new finding with possible clinical relevance is a correlation between the individual plasma values of the 8-OHdG versus anti-inflammatory interleukin IL-10 and 8-OHdG versus IL-1beta (proinflammatory) in the MC and LC patients suggesting that inflammation and oxidative stress are related.	8-ohdg	108-114	interleukin 1 beta	Homo sapiens	176-184
27916089-9	2016	THC blocked the effects of estrogen on the IL-1beta and estrogen treated cells, and the mRNA and protein levels of IL-6, IkappaBalpha and p-IkappaBalpha had no significant difference compared with IL-1beta treated cells.	Dronabinol	0-3	interleukin 1 beta	Homo sapiens	43-51
27894300-0	2016	Pleural inhibition of the caspase-1/IL-1beta pathway diminishes profibrotic lung toxicity of bleomycin.	Bleomycin	93-102	interleukin 1 beta	Homo sapiens	36-44
27894300-4	2016	In this work, we explored the role of IL-1beta/caspase-1 signaling in bleomycin lung toxicity and in pleural mesothelial cell transformation.	Bleomycin	70-79	interleukin 1 beta	Homo sapiens	38-46
27883019-8	2016	17-oxo-DHA, but not FP, was able to suppress the release of mature IL-1beta through inhibition of the NLRP3 inflammasome.	(4Z,7Z,10Z,13Z,15E,19Z)-17-Oxodocosahexaenoic acid	0-10	interleukin 1 beta	Homo sapiens	67-75
27881823-4	2016	P2X7 is a ligand-gated ion channel that, upon sensing adenosine 5"-triphosphate released by damaged cells, initiates a proinflammatory signaling cascade, including release of cytokines, such as interleukin-1beta (IL-1beta).	Adenosine Triphosphate	54-79	interleukin 1 beta	Homo sapiens	194-211
27881823-4	2016	P2X7 is a ligand-gated ion channel that, upon sensing adenosine 5"-triphosphate released by damaged cells, initiates a proinflammatory signaling cascade, including release of cytokines, such as interleukin-1beta (IL-1beta).	Adenosine Triphosphate	54-79	interleukin 1 beta	Homo sapiens	213-221
27881823-8	2016	In endotoxin-treated human blood, Dano1 was 1000 times more potent in preventing IL-1beta release than small-molecule P2X7 antagonists currently in clinical development.	dano1	34-39	interleukin 1 beta	Homo sapiens	81-89
27746177-5	2016	However, the expression of aggrecan and Col II at protein levels were significantly reduced by IL-1beta treatment, which were reversed by Carvedilol in a dose dependent manner, suggesting the inhibitory effects of Carvedilol on the expression of aggrecan and Col II are at post-translational modification levels.	Carvedilol	138-148	interleukin 1 beta	Homo sapiens	95-103
27746177-5	2016	However, the expression of aggrecan and Col II at protein levels were significantly reduced by IL-1beta treatment, which were reversed by Carvedilol in a dose dependent manner, suggesting the inhibitory effects of Carvedilol on the expression of aggrecan and Col II are at post-translational modification levels.	Carvedilol	214-224	interleukin 1 beta	Homo sapiens	95-103
27746177-6	2016	In addition, it was shown that IL-1beta treatment highly induced MMP-1 and MMP-13 expression in SW1353 chondrocytes at both gene and protein expression levels, which were restored by Carvedilol in a dose dependent manner.	Carvedilol	183-193	interleukin 1 beta	Homo sapiens	31-39
27746177-7	2016	Mechanistically, exposure to IL-1beta increased phosphorylation of IKK-alpha/beta and degradation of IkappaB-alpha in SW1353 chondrocytes, which were suppressed by pretreatment with Carvedilol.	Carvedilol	182-192	interleukin 1 beta	Homo sapiens	29-37
27746177-8	2016	Administration of Carvedilol inhibited IL-1beta-induced translocation of NF-kappaB p65 from cytosol to nucleus manner.	Carvedilol	18-28	interleukin 1 beta	Homo sapiens	39-47
27746177-9	2016	Notably, a luciferase reporter assay showed that IL-1beta severely increased NF-kappaB luciferase activity, which was markedly suppressed by Carvedilol treatment.	Carvedilol	141-151	interleukin 1 beta	Homo sapiens	49-57
27565222-7	2016	CapNO inhibited IL-1beta-stimulated NF-kB pathway by down-regulating IKK-alpha and inducing IkB-alpha directly.	capno	0-5	interleukin 1 beta	Homo sapiens	16-24
27895484-6	2016	PCA/Dex showed mildly increased expression of GFP and lower mRNA expression of inflammatory cytokines (IL1b, IL12, and INFr) than did Dex-free PCA nanoparticles and Lipofectamine  reagent in HEI-OC1 cells.	Dexamethasone	4-7	interleukin 1 beta	Homo sapiens	103-107
27965661-10	2016	LPS/aluminum hydroxide-induced release of IL-1beta and IL-6 was not inhibited by anti-TNFalpha treatment.	Aluminum Hydroxide	4-22	interleukin 1 beta	Homo sapiens	42-50
27655706-9	2016	Blood levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta increased in gemcitabine alone group, however, it was decreased in gemcitabine with GV1001 group.	gemcitabine	96-107	interleukin 1 beta	Homo sapiens	74-82
27771306-3	2016	We found that the overexpression of HMGB1 A-box significantly decreased the IL-1beta-stimulated the production of MMP-1, MMP-3 and MMP-9, and also reduced the elevated levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) associated with the inhibition of prostaglandin E2 (PGE2) and nitric oxide (NO) production in IL-1beta-stimulated chondrocytes.	Dinoprostone	280-296	interleukin 1 beta	Homo sapiens	76-84
27771306-3	2016	We found that the overexpression of HMGB1 A-box significantly decreased the IL-1beta-stimulated the production of MMP-1, MMP-3 and MMP-9, and also reduced the elevated levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) associated with the inhibition of prostaglandin E2 (PGE2) and nitric oxide (NO) production in IL-1beta-stimulated chondrocytes.	Dinoprostone	298-302	interleukin 1 beta	Homo sapiens	76-84
27771306-3	2016	We found that the overexpression of HMGB1 A-box significantly decreased the IL-1beta-stimulated the production of MMP-1, MMP-3 and MMP-9, and also reduced the elevated levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) associated with the inhibition of prostaglandin E2 (PGE2) and nitric oxide (NO) production in IL-1beta-stimulated chondrocytes.	Nitric Oxide	188-200	interleukin 1 beta	Homo sapiens	76-84
27771306-3	2016	We found that the overexpression of HMGB1 A-box significantly decreased the IL-1beta-stimulated the production of MMP-1, MMP-3 and MMP-9, and also reduced the elevated levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) associated with the inhibition of prostaglandin E2 (PGE2) and nitric oxide (NO) production in IL-1beta-stimulated chondrocytes.	Nitric Oxide	188-200	interleukin 1 beta	Homo sapiens	340-348
27745952-3	2016	Alum-adjuvanted vaccines induce local inflammatory nodules at injection sites, and the systemic and local production of the inflammatory cytokines, IL-1beta, IL-6, and TNF-alpha, has been reported to occur three hours after vaccinations.	aluminum sulfate	0-4	interleukin 1 beta	Homo sapiens	148-156
28516117-4	2016	Here, we describe how to co-transfect the NLRP3 inflammasome components into HEK293T cells, which enables inflammasome activation and the production of IL-1beta upon stimulation with nigericin.	Nigericin	183-192	interleukin 1 beta	Homo sapiens	152-160
27713966-0	2016	Hydroxysafflor yellow A inhibits IL-1beta-induced release of IL-6, IL-8, and MMP-1 via suppression of ERK, NF-kappaB and AP-1 signaling in SW982 human synovial cells.	hydroxysafflor yellow A	0-23	interleukin 1 beta	Homo sapiens	33-41
27713966-7	2016	These results indicate that the inhibitory effects of HSYA on IL-1beta-induced IL-6, IL-8 and MMP-1 release might be mediated via suppression of ERK, nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) signaling pathways.	hydroxysafflor yellow A	54-58	interleukin 1 beta	Homo sapiens	62-70
27824863-12	2016	On the other hand, 5-AzadC significantly reduced IL-1beta-mediated cell proliferation by nearly 2.5 fold (p = 0.006).	Decitabine	19-26	interleukin 1 beta	Homo sapiens	49-57
27612965-3	2016	We detected cyclooxygenase-2 (COX-2)-dependent production of both proinflammatory and proresolving prostaglandins (PGs) in conditioned culture medium from HLFs treated with a proinflammatory stimulus, IL-1beta.	Prostaglandins	115-118	interleukin 1 beta	Homo sapiens	201-209
27612965-5	2016	Next, we used a cell-based luciferase reporter to confirm the ability of HLF supernatants to activate PPARgamma, demonstrating, for the first time, that primary HLFs activated with proinflammatory IL-1beta or cigarette smoke extract produce functional PPARgamma ligands; this phenomenon is temporally regulated, COX-2- and lipocalin-type PGD synthase-dependent, and enhanced by arachidonic acid supplementation.	Arachidonic Acid	378-394	interleukin 1 beta	Homo sapiens	197-205
26659566-0	2016	Indoxyl sulfate enhances IL-1beta-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFkappaB/AP-1 pathway.	Indican	0-15	interleukin 1 beta	Homo sapiens	25-33
26659566-0	2016	Indoxyl sulfate enhances IL-1beta-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFkappaB/AP-1 pathway.	Reactive Oxygen Species	115-118	interleukin 1 beta	Homo sapiens	25-33
26659566-2	2016	In the present study, in cardiovascular surgery-related AKI patients, who are known to have high plasma levels of the uremic toxin indoxyl sulfate (IS), plasma levels of IL-1beta were found to be positively correlated with plasma levels of the adhesion molecule E-selectin.	Indican	131-146	interleukin 1 beta	Homo sapiens	170-178
26659566-5	2016	IS pretreatment of HUVECs significantly increased IL-1beta-induced E-selectin expression, monocyte adhesion, and the phosphorylation of mitogen-activated protein kinases (ERK, p38, and JNK) and transcription factors (NF-kappaB and AP-1), and phosphorylation was decreased by pretreatment with inhibitors of ERK1/2 (PD98059), p38 MAPK (SB202190), and JNK (SP600125).	pyrazolanthrone	355-363	interleukin 1 beta	Homo sapiens	50-58
26659566-6	2016	Furthermore, IS increased IL-1beta-induced reactive oxygen species (ROS) production and this effect was inhibited by pretreatment with N-acetylcysteine (a ROS scavenger) or apocynin (a NADPH oxidase inhibitor).	Reactive Oxygen Species	43-66	interleukin 1 beta	Homo sapiens	26-34
26659566-6	2016	Furthermore, IS increased IL-1beta-induced reactive oxygen species (ROS) production and this effect was inhibited by pretreatment with N-acetylcysteine (a ROS scavenger) or apocynin (a NADPH oxidase inhibitor).	Reactive Oxygen Species	68-71	interleukin 1 beta	Homo sapiens	26-34
26659566-6	2016	Furthermore, IS increased IL-1beta-induced reactive oxygen species (ROS) production and this effect was inhibited by pretreatment with N-acetylcysteine (a ROS scavenger) or apocynin (a NADPH oxidase inhibitor).	Acetylcysteine	135-151	interleukin 1 beta	Homo sapiens	26-34
26659566-6	2016	Furthermore, IS increased IL-1beta-induced reactive oxygen species (ROS) production and this effect was inhibited by pretreatment with N-acetylcysteine (a ROS scavenger) or apocynin (a NADPH oxidase inhibitor).	Reactive Oxygen Species	155-158	interleukin 1 beta	Homo sapiens	26-34
26659566-6	2016	Furthermore, IS increased IL-1beta-induced reactive oxygen species (ROS) production and this effect was inhibited by pretreatment with N-acetylcysteine (a ROS scavenger) or apocynin (a NADPH oxidase inhibitor).	acetovanillone	173-181	interleukin 1 beta	Homo sapiens	26-34
26659566-8	2016	Moreover, IS-enhanced E-selectin expression in IL-1beta-treated HUVECs was inhibited by Bay11-7082, a NF-kappaB inhibitor.	3-(4-methylphenylsulfonyl)-2-propenenitrile	88-98	interleukin 1 beta	Homo sapiens	47-55
26320741-0	2016	The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1beta transcription and processing in monocytes.	Reactive Oxygen Species	57-60	interleukin 1 beta	Homo sapiens	76-84
26320741-5	2016	LPS and Pam3csk4 also induced IRAK1/4-, ERK- and ROS-dependent activation of activator protein-1 (AP-1), IL-1beta transcription, and IL-1beta processing because significant inhibition in AP-1 activity, IL-1beta transcription, Pro- and mature IL-beta expression, and caspase-1 activity was observed with PD98059, U0126, DPI, NAC, an IRAK1/4 inhibitor, tanshinone IIa, and IRAK1 siRNA treatment.	Reactive Oxygen Species	49-52	interleukin 1 beta	Homo sapiens	105-113
26320741-5	2016	LPS and Pam3csk4 also induced IRAK1/4-, ERK- and ROS-dependent activation of activator protein-1 (AP-1), IL-1beta transcription, and IL-1beta processing because significant inhibition in AP-1 activity, IL-1beta transcription, Pro- and mature IL-beta expression, and caspase-1 activity was observed with PD98059, U0126, DPI, NAC, an IRAK1/4 inhibitor, tanshinone IIa, and IRAK1 siRNA treatment.	Reactive Oxygen Species	49-52	interleukin 1 beta	Homo sapiens	133-141
26320741-5	2016	LPS and Pam3csk4 also induced IRAK1/4-, ERK- and ROS-dependent activation of activator protein-1 (AP-1), IL-1beta transcription, and IL-1beta processing because significant inhibition in AP-1 activity, IL-1beta transcription, Pro- and mature IL-beta expression, and caspase-1 activity was observed with PD98059, U0126, DPI, NAC, an IRAK1/4 inhibitor, tanshinone IIa, and IRAK1 siRNA treatment.	Reactive Oxygen Species	49-52	interleukin 1 beta	Homo sapiens	133-141
26320741-8	2016	In the present study, we demonstrate that the TLR4- and TLR2-induced IRAK-ERK pathway cross-talks with p67phox-Nox-2 for ROS generation, thus regulating IL-1beta transcription and processing in monocytic cells.	Reactive Oxygen Species	121-124	interleukin 1 beta	Homo sapiens	153-161
27624102-13	2016	Notably, selective gene silencing or inhibition of caspase-4/5 reduced palmitate-induced release of IL-1beta and IL-18.	Palmitates	71-80	interleukin 1 beta	Homo sapiens	100-108
27598863-9	2016	Pearson correlation exhibited a relationship between the ABTS assay and the expression of three out of five analyzed genes; IL-1beta, IL-6 and IL-8.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	57-61	interleukin 1 beta	Homo sapiens	124-132
27590709-7	2016	We observed that IL-1beta contributes to the apoptosis of enterocytes in mucositis induced by 5-FU.	Fluorouracil	94-98	interleukin 1 beta	Homo sapiens	17-25
26832782-11	2016	The levels of IL-1beta and TNF-alpha were significantly higher at zirconia implants than at teeth.	zirconium oxide	66-74	interleukin 1 beta	Homo sapiens	14-22
27673556-8	2016	In vitro exposure of myometrial cells to stretch and IL-1beta increased OTR levels and reduced basal and forskolin-stimulated cAMP and PKA activity, as judged by phospho-cAMP response element-binding protein levels, but neither stretch nor IL-1beta had any effect on PKA or EPAC1 levels.	Colforsin	105-114	interleukin 1 beta	Homo sapiens	53-61
27603969-4	2016	Advances in the understanding of the role of pyrin in the regulation of interleukin (IL)-1beta activation has led to use of anti-IL-1 agents for colchicine-resistant FMF.	Colchicine	145-155	interleukin 1 beta	Homo sapiens	72-94
27624102-0	2016	Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1beta and IL-18 release.	Fatty Acids	0-21	interleukin 1 beta	Homo sapiens	74-82
27624102-6	2016	We hypothesized that 1) human monocytes from obese patients show caspase activation, and 2) fatty acids trigger this response and consequent release of IL-1beta/IL-18.	Fatty Acids	92-103	interleukin 1 beta	Homo sapiens	152-160
27624102-11	2016	Palmitate, but not palmitoleate, increased caspase activity in parallel to the release of IL-1beta and IL-18.	Palmitates	0-9	interleukin 1 beta	Homo sapiens	90-98
27640071-6	2016	The OR for PD in individuals with high NO2 exposure ( 75th percentile) and the AA genotype of IL1B rs16944 was 3.10 (95% CI=1.14-8.38) compared with individuals with lower NO2 exposure (<75th percentile) and the GG genotype.	Nitrogen Dioxide	172-175	interleukin 1 beta	Homo sapiens	94-98
27743553-0	2016	Effects of platycodin D on IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes.	platycodin D	11-23	interleukin 1 beta	Homo sapiens	27-35
27743553-6	2016	The results showed that PYD significantly inhibited IL-1beta-induced MMP1, MMP13, IL-8, RANTES, PGE2, and NO production.	Dinoprostone	96-100	interleukin 1 beta	Homo sapiens	52-60
27588909-2	2016	We previously reported that phloretin could inhibit the inflammatory response and reduce intercellular adhesion molecule 1 (ICAM-1) expression in interleukin (IL)-1beta-activated human lung epithelial cells.	Phloretin	28-37	interleukin 1 beta	Homo sapiens	146-168
27649267-6	2016	In the Indian cohort, 14.5% of the variance in morphine use score was explained by IL1B rs1143634 (increased) and TGFB1 rs1800469 (decreased).	Morphine	47-55	interleukin 1 beta	Homo sapiens	83-87
27310028-9	2016	IL-1beta-induced MUC5AC messenger RNA (mRNA) expression was most significantly decreased by 10 muM atorvastatin, to 1.4 +- 0.2-fold of the level of the untreated control group, as opposed to an increase to 4.7 +- 0.5-fold for IL-1beta alone, and this suppression of MUC5AC expression was dose-dependent.	Atorvastatin	99-111	interleukin 1 beta	Homo sapiens	0-8
27310028-11	2016	CONCLUSION: These results suggest that atorvastatin is the most potent of the assayed statins with respect to suppression of IL-1beta-induced MUC5AC mRNA expression, and may be considered as an anti-hypersecretory agent.	Atorvastatin	39-51	interleukin 1 beta	Homo sapiens	125-133
27329564-5	2016	We demonstrate here that HDL is able to suppress IL-1beta secretion in response to cholesterol crystals in THP-1 cells and in human-monocyte-derived macrophages.	Cholesterol	83-94	interleukin 1 beta	Homo sapiens	49-57
27377765-1	2016	Mevalonate kinase deficiency (MKD) is caused by mutations in a key enzyme of the mevalonate-cholesterol biosynthesis pathway, leading to recurrent autoinflammatory disease characterised by enhanced release of interleukin-1beta (IL-1beta).	Mevalonic Acid	81-91	interleukin 1 beta	Homo sapiens	209-226
27377765-1	2016	Mevalonate kinase deficiency (MKD) is caused by mutations in a key enzyme of the mevalonate-cholesterol biosynthesis pathway, leading to recurrent autoinflammatory disease characterised by enhanced release of interleukin-1beta (IL-1beta).	Cholesterol	92-103	interleukin 1 beta	Homo sapiens	209-226
27694492-4	2016	We show that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 expression and production of IL-1beta and IL-18.	Calcium	205-212	interleukin 1 beta	Homo sapiens	273-281
28167474-5	2016	And the ELISA and Western-blot methods were used to explore the regulatory effect of Caspse-11 on Interleukin-1beta in the fungal keratitis.	caspse-11	85-94	interleukin 1 beta	Homo sapiens	98-115
27650753-5	2016	Here we found that zofenoprilat, in a CSE/H2S-mediated manner, abolished all the inflammatory features induced by interlukin-1beta (IL-1beta) in human umbilical vein endothelial cells (HUVEC), especially the NF-kappaB/cyclooxygenase-2 (COX-2)/prostanoid biochemical pathway.	zofenoprilate	19-31	interleukin 1 beta	Homo sapiens	132-140
27650753-5	2016	Here we found that zofenoprilat, in a CSE/H2S-mediated manner, abolished all the inflammatory features induced by interlukin-1beta (IL-1beta) in human umbilical vein endothelial cells (HUVEC), especially the NF-kappaB/cyclooxygenase-2 (COX-2)/prostanoid biochemical pathway.	Hydrogen Sulfide	42-45	interleukin 1 beta	Homo sapiens	132-140
27650753-5	2016	Here we found that zofenoprilat, in a CSE/H2S-mediated manner, abolished all the inflammatory features induced by interlukin-1beta (IL-1beta) in human umbilical vein endothelial cells (HUVEC), especially the NF-kappaB/cyclooxygenase-2 (COX-2)/prostanoid biochemical pathway.	Prostaglandins	243-253	interleukin 1 beta	Homo sapiens	132-140
27650753-6	2016	The pre-incubation with zofenoprilat/CSE dependent H2S prevented IL-1beta induced paracellular hyperpermeability through the control of expression and localization of cell-cell junctional markers ZO-1 and VE-cadherin.	zofenoprilate	24-36	interleukin 1 beta	Homo sapiens	65-73
27650753-6	2016	The pre-incubation with zofenoprilat/CSE dependent H2S prevented IL-1beta induced paracellular hyperpermeability through the control of expression and localization of cell-cell junctional markers ZO-1 and VE-cadherin.	Hydrogen Sulfide	51-54	interleukin 1 beta	Homo sapiens	65-73
27650753-8	2016	Interestingly, this anti-inflammatory activity was also confirmed in vascular smooth muscle cells and fibroblasts as zofenoprilat reduced, in both cell lines, proliferation, migration and COX-2 expression induced by IL-1beta, but independently from the SH moiety and H2S availability.	zofenoprilate	117-129	interleukin 1 beta	Homo sapiens	216-224
27780541-7	2016	Silencing ATF3 significantly increased IL-1beta- or fsl-1-induced expression of pro-inflammatory cytokines (TNF-alpha, IL-1alpha, IL-1beta, IL-6) and chemokines (IL-8 and monocyte chemoattractant protein-1 (MCP-1)); cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin PGF2alpha release; and MMP-9 expression.	Prostaglandins	261-274	interleukin 1 beta	Homo sapiens	39-47
27650753-8	2016	Interestingly, this anti-inflammatory activity was also confirmed in vascular smooth muscle cells and fibroblasts as zofenoprilat reduced, in both cell lines, proliferation, migration and COX-2 expression induced by IL-1beta, but independently from the SH moiety and H2S availability.	Hydrogen Sulfide	267-270	interleukin 1 beta	Homo sapiens	216-224
27490714-7	2016	RESULTS: Following intramuscular capsaicin injection, pro-inflammatory cytokines [TNFalpha, IL-6, IL-8] significantly increased (percent rise from baseline) in both groups, whereas IL-1beta significantly increased in the PTSD group only.	Capsaicin	33-42	interleukin 1 beta	Homo sapiens	181-189
27782997-9	2016	After 2 hours, topical minocycline reduced concentrations of the inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha (p &lt; 0.01), and inflammatory cell counts in wound tissue (p &lt; 0.05).	Minocycline	23-34	interleukin 1 beta	Homo sapiens	88-105
27782997-10	2016	In noninfected wounds, topical minocycline significantly reduced interleukin-1beta, interleukin-6, and inflammatory cell counts after 4 hours (p &lt; 0.01).	Minocycline	31-42	interleukin 1 beta	Homo sapiens	65-82
29908114-4	2016	The inhibition effect of oleanolic acid on inflammatory factors stimulated by IL-1beta may be worked through MAPK, PI3K/Akt and NF-kappaB signaling pathways.	Oleanolic Acid	25-39	interleukin 1 beta	Homo sapiens	78-86
27697591-6	2016	Finally, our results showed that pharmacological inhibitors for MAPK and NFkappaB significantly reduced IL-6 secretion stimulated by Pg LPS and IL-1beta, indicating that the MyD88-dependent MAPK and NFkappaB signaling pathways are essential for the upregulation of proinflammatory cytokine expression by Pg LPS and IL-1beta.	pg	133-135	interleukin 1 beta	Homo sapiens	315-323
29908114-0	2016	[Inhibitory effect of oleanolic acid on inflammatory response in IL-1beta-stimulated human synovial sarcoma SW982 cells].	Oleanolic Acid	22-36	interleukin 1 beta	Homo sapiens	65-73
27788256-8	2016	High extracellular NaCl induced NLRP3 and pro-IL-1beta gene expression, while the gene expression of further inflammasome-associated proteins (NLRP1, NLRP2, NLRP6, NLRP7, NLRP12, NLRC4, AIM2, ASC, procaspase-1, pro-IL-18) was not altered or below the detection threshold.	Sodium Chloride	19-23	interleukin 1 beta	Homo sapiens	42-54
27843307-11	2016	CONCLUSION: The findings of this research indicate that the consumption of CLA supplementation can be effective in regulating the appetite and improving the nutritional status of patients suffering from COPD through adjusting the serum level of IL1beta.	Linoleic Acids, Conjugated	75-78	interleukin 1 beta	Homo sapiens	245-252
27788256-11	2016	High NaCl induced a transient increase of the NLRP3 protein level and a moderate NLRP3 inflammasome activation, as indicated by the transient increase of the cytosolic level of mature IL-1beta.	Sodium Chloride	5-9	interleukin 1 beta	Homo sapiens	184-192
27567548-2	2016	Here, we have investigated the regulatory mechanism of IL-1beta expression, and the inhibitory effect of zerumbone (ZER) on IL-1beta expression and IL-1beta-induced signatures, including cell invasion and signaling activation in triple negative breast cancer (TNBC) cells.	zerumbone	105-114	interleukin 1 beta	Homo sapiens	124-132
27567548-2	2016	Here, we have investigated the regulatory mechanism of IL-1beta expression, and the inhibitory effect of zerumbone (ZER) on IL-1beta expression and IL-1beta-induced signatures, including cell invasion and signaling activation in triple negative breast cancer (TNBC) cells.	zerumbone	105-114	interleukin 1 beta	Homo sapiens	124-132
27638862-10	2016	Interestingly, pro-IL-1beta and inflammasome components ASC and caspase-1 were released by ATP-activated macrophages through a vesicle-mediated secretion pathway.	Adenosine Triphosphate	91-94	interleukin 1 beta	Homo sapiens	15-27
27776166-0	2016	Glucosamine Downregulates the IL-1beta-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms.	Glucosamine	0-11	interleukin 1 beta	Homo sapiens	30-38
27776166-0	2016	Glucosamine Downregulates the IL-1beta-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms.	o-glcnac	124-132	interleukin 1 beta	Homo sapiens	30-38
27776166-5	2016	The results indicated that GlcN significantly downregulates the expression of 187 genes (&lt;=1/1.5-fold) and upregulates the expression of 194 genes (&gt;=1.5-fold) in IL-1beta-stimulated MH7A cells.	Glucosamine	27-31	interleukin 1 beta	Homo sapiens	169-177
27731349-1	2016	Excessive production of reactive oxygen species (ROS) induced by hyperglycemia increased the secretion of interleukin-1beta (IL-1beta), which contributes to the pathogenesis of diabetes and its complications.	Reactive Oxygen Species	24-47	interleukin 1 beta	Homo sapiens	106-123
27739445-6	2016	Using ex vivo human CRC explants, quininib significantly reduced the secretions of IL-6, IL-8, VEGF, ENA-78, GRO-alpha, TNF, IL-1beta and MCP-1 ex vivo (all values p &lt; 0.01).	quininib	34-42	interleukin 1 beta	Homo sapiens	125-133
27731349-1	2016	Excessive production of reactive oxygen species (ROS) induced by hyperglycemia increased the secretion of interleukin-1beta (IL-1beta), which contributes to the pathogenesis of diabetes and its complications.	Reactive Oxygen Species	24-47	interleukin 1 beta	Homo sapiens	125-133
27731349-1	2016	Excessive production of reactive oxygen species (ROS) induced by hyperglycemia increased the secretion of interleukin-1beta (IL-1beta), which contributes to the pathogenesis of diabetes and its complications.	Reactive Oxygen Species	49-52	interleukin 1 beta	Homo sapiens	106-123
27731349-1	2016	Excessive production of reactive oxygen species (ROS) induced by hyperglycemia increased the secretion of interleukin-1beta (IL-1beta), which contributes to the pathogenesis of diabetes and its complications.	Reactive Oxygen Species	49-52	interleukin 1 beta	Homo sapiens	125-133
27731349-3	2016	Here, we identified that HG (30 mM glucose for 48 h) induced the activation of the NLRP3-ASC inflammasome, leading to caspase-1 activation, and IL-1beta and IL-18 secretion in human monocytic cell lines.	Glucose	35-42	interleukin 1 beta	Homo sapiens	144-152
27777559-5	2016	Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages.	Curcumin	9-17	interleukin 1 beta	Homo sapiens	94-102
27777559-5	2016	Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 beta	Homo sapiens	94-102
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	140-148
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 beta	Homo sapiens	140-148
27551049-1	2016	Although the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, mediates dexamethasone-induced repression of MAPKs, 14 of 46 interleukin-1beta (IL1B)-induced mRNAs were significantly enhanced by DUSP1 overexpression in pulmonary A549 cells.	Dexamethasone	82-95	interleukin 1 beta	Homo sapiens	153-157
27522258-9	2016	Moreover, Bakkenolide A was found to inhibit inflammation, induce apoptosis and cell death in leukemia cells via PI3K-regulated signaling pathway, down-regulating IKKs expression and suppressing in proinflammatory cytokines of IL-1beta, IL-18 and TNF-alpha.	bakkenolide A	10-23	interleukin 1 beta	Homo sapiens	227-235
27555113-0	2016	Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1beta-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte.	Vorinostat	30-40	interleukin 1 beta	Homo sapiens	59-67
27555113-0	2016	Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1beta-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte.	Vorinostat	42-46	interleukin 1 beta	Homo sapiens	59-67
27555113-9	2016	Interestingly, SAHA rescued the COL2A1 and ACAN expression in OA chondrocytes that was down-regulated by IL-1beta.	Vorinostat	15-19	interleukin 1 beta	Homo sapiens	105-113
27590705-0	2016	6"-O-Caffeoyldihydrosyringin isolated from Aster glehni suppresses lipopolysaccharide-induced iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 expression via NF-kappaB and AP-1 inactivation in RAW 264.7 macrophages.	6"-o-caffeoyldihydrosyringin	0-28	interleukin 1 beta	Homo sapiens	118-126
27694988-0	2016	Monosodium urate crystal-induced pro-interleukin-1beta production is post-transcriptionally regulated via the p38 signaling pathway in human monocytes.	monosodium urate crystal	0-24	interleukin 1 beta	Homo sapiens	33-54
27590705-4	2016	Consistent with these observations, CDS concentration-dependently inhibited LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxidase-2 (COX-2) expression at the protein level and also iNOS, COX-2, TNF-alpha, and IL-6, IL-1beta expression at the mRNA level.	Cadmium	36-39	interleukin 1 beta	Homo sapiens	229-237
27590705-3	2016	In addition, CDS was found to concentration-dependently reduce the production of NO, PGE2, and the pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) induced by LPS in macrophages.	Cadmium	13-16	interleukin 1 beta	Homo sapiens	198-215
27699014-7	2016	Patients that received acarbose plus insulin demonstrated greater reduction in 8-iso PGF2alpha, Hs-CRP, TNF-alpha, IL-1beta and IL-6 levels when compared with the insulin only patients.	Acarbose	23-31	interleukin 1 beta	Homo sapiens	115-123
27590705-3	2016	In addition, CDS was found to concentration-dependently reduce the production of NO, PGE2, and the pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) induced by LPS in macrophages.	Cadmium	13-16	interleukin 1 beta	Homo sapiens	217-225
27590705-6	2016	Taken together, these results suggest that the anti-inflammatory effect of CDS is associated with the downregulation of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 expression via the negative regulation of NF-kappaB and AP-1 activation in LPS-induced RAW 264.7 macrophages.	Cadmium	75-78	interleukin 1 beta	Homo sapiens	144-152
27799147-9	2016	RESULTS: MiR-138-5p was significantly increased in OA cartilage and in chondrocytes in response to IL-1beta-stimulation.	mir-138-5p	9-19	interleukin 1 beta	Homo sapiens	99-107
27799147-10	2016	Overexpression of miR-138-5p significantly increased the IL-1beta-induced downregulation of COL2A1, ACAN, and GAGs, and increased the IL-1beta-induced over expression of MMP-13.We found that FOXC1 is directly regulated by miR-138-5p.	mir-138-5p	18-28	interleukin 1 beta	Homo sapiens	57-65
27799147-0	2016	Silencing of microRNA-138-5p promotes IL-1beta-induced cartilage degradation in human chondrocytes by targeting FOXC1: miR-138 promotes cartilage degradation.	mir-138	119-126	interleukin 1 beta	Homo sapiens	38-46
27799147-10	2016	Overexpression of miR-138-5p significantly increased the IL-1beta-induced downregulation of COL2A1, ACAN, and GAGs, and increased the IL-1beta-induced over expression of MMP-13.We found that FOXC1 is directly regulated by miR-138-5p.	mir-138-5p	18-28	interleukin 1 beta	Homo sapiens	134-142
27799147-3	2016	The purpose of our study was to explore the functional role and underlying mechanism of miR-138-5p in interleukin-1 beta (IL-1beta)-induced extracellular matrix (ECM) degradation of OA cartilage.	mir-138-5p	88-98	interleukin 1 beta	Homo sapiens	102-120
27799147-3	2016	The purpose of our study was to explore the functional role and underlying mechanism of miR-138-5p in interleukin-1 beta (IL-1beta)-induced extracellular matrix (ECM) degradation of OA cartilage.	mir-138-5p	88-98	interleukin 1 beta	Homo sapiens	122-130
27799147-10	2016	Overexpression of miR-138-5p significantly increased the IL-1beta-induced downregulation of COL2A1, ACAN, and GAGs, and increased the IL-1beta-induced over expression of MMP-13.We found that FOXC1 is directly regulated by miR-138-5p.	Glycosaminoglycans	110-114	interleukin 1 beta	Homo sapiens	57-65
27799147-10	2016	Overexpression of miR-138-5p significantly increased the IL-1beta-induced downregulation of COL2A1, ACAN, and GAGs, and increased the IL-1beta-induced over expression of MMP-13.We found that FOXC1 is directly regulated by miR-138-5p.	mir-138-5p	222-232	interleukin 1 beta	Homo sapiens	57-65
27799147-10	2016	Overexpression of miR-138-5p significantly increased the IL-1beta-induced downregulation of COL2A1, ACAN, and GAGs, and increased the IL-1beta-induced over expression of MMP-13.We found that FOXC1 is directly regulated by miR-138-5p.	mir-138-5p	222-232	interleukin 1 beta	Homo sapiens	134-142
27799147-14	2016	Silencing of microRNA-138-5p promotes IL-1beta-induced cartilage degradation in human chondrocytes by targeting FOXC1: miR-138 promotes cartilage degradation.	mir-138	119-126	interleukin 1 beta	Homo sapiens	38-46
27614934-0	2016	Corrigendum to "Angiotensin(1-7) attenuated angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1beta/Smad circuit": [Free Radic.	nicotine 1-N-oxide	96-99	interleukin 1 beta	Homo sapiens	142-150
27192552-18	2016	Dexamethasone restored IL-13-induced miR-181b-5p down-regulation and suppressed IL-13-induced SPP1, IL-1beta and CCL11 expression.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	100-108
27614934-0	2016	Corrigendum to "Angiotensin(1-7) attenuated angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1beta/Smad circuit": [Free Radic.	Hydrogen Peroxide	108-112	interleukin 1 beta	Homo sapiens	142-150
26771135-11	2016	CONCLUSIONS: Higher levels of TNF-alpha, IL-6, and IL-1beta might predict nonresponse to fluoxetine treatment in children.	Fluoxetine	89-99	interleukin 1 beta	Homo sapiens	51-59
27233805-0	2016	Base-modified UDP-sugars reduce cell surface levels of P-selectin glycoprotein 1 (PSGL-1) on IL-1beta-stimulated human monocytes.	Uridine Diphosphate Sugars	14-24	interleukin 1 beta	Homo sapiens	93-101
26968431-2	2016	This was explored by measuring AgNP-stimulated gene expression of the pro-inflammatory cytokines interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in THP-1 monocytes.	agnp	31-35	interleukin 1 beta	Homo sapiens	112-116
26968431-4	2016	The aims of the study were to clearly demonstrate that AgNP can significantly up-regulate pro-inflammatory cytokine gene expression of IL-1, IL-6 and TNF-alpha in both THP-1 cells and primary blood monocytes thus indicating a rapid response to AgNP in circulation.	agnp	55-59	interleukin 1 beta	Homo sapiens	135-139
26968431-4	2016	The aims of the study were to clearly demonstrate that AgNP can significantly up-regulate pro-inflammatory cytokine gene expression of IL-1, IL-6 and TNF-alpha in both THP-1 cells and primary blood monocytes thus indicating a rapid response to AgNP in circulation.	agnp	244-248	interleukin 1 beta	Homo sapiens	135-139
27178341-0	2016	Chitosan oligosaccharides inhibit IL-1beta-induced chondrocyte apoptosis via the P38 MAPK signaling pathway.	chitosan oligosaccharides	0-25	interleukin 1 beta	Homo sapiens	34-42
27178341-2	2016	In this study, the protective effects of COS against IL-1beta-induced chondrocyte apoptosis were evaluated and the underlying mechanisms were elucidated.	carbonyl sulfide	41-44	interleukin 1 beta	Homo sapiens	53-61
27178341-3	2016	Results showed that COS not only inhibited cell apoptosis in a dose-dependent manner but also ameliorated IL-1beta-induced nuclear chromatin damage and mitochondrial membrane potential in chondrocytes.	carbonyl sulfide	20-23	interleukin 1 beta	Homo sapiens	106-114
27178341-4	2016	In IL-1beta-treated chondrocytes, COS downregulated the expression of Bax and caspase-3 but upregulated the expression of Bcl-2 by inhibiting the phosphorylated p38 mitogen-activated protein kinase (MAPK).	carbonyl sulfide	34-37	interleukin 1 beta	Homo sapiens	3-11
27178341-6	2016	These results suggested that COS effectively inhibits the IL-1beta-induced apoptosis of chondrocytes by activating the p38 MAPK signaling pathway.	carbonyl sulfide	29-32	interleukin 1 beta	Homo sapiens	58-66
27697223-8	2016	Further studies revealed that cortisol inhibited the expression of interleukin-1beta and 6 in decidual stromal cells and villous trophoblasts, and stimulated expression of human chorionic gonadotropin in villous trophoblasts.	Hydrocortisone	30-38	interleukin 1 beta	Homo sapiens	67-84
27450903-7	2016	In silico target prediction revealed miR-1 targets EDN1, G6PD, HSP60, HSP70, SERP1, SIRT1 &amp; TYR; miR-184 targets EZR &amp; LAMP1; miR-328 targets IL1B, POLH &amp; TRPM1; miR-383 targets EDN1 &amp; TYRP1; and miR-577 targets PTPN22 &amp; TYRP1 which were corroborated by our validation study.	Adenosine Monophosphate	91-94	interleukin 1 beta	Homo sapiens	150-154
27450903-7	2016	In silico target prediction revealed miR-1 targets EDN1, G6PD, HSP60, HSP70, SERP1, SIRT1 &amp; TYR; miR-184 targets EZR &amp; LAMP1; miR-328 targets IL1B, POLH &amp; TRPM1; miR-383 targets EDN1 &amp; TYRP1; and miR-577 targets PTPN22 &amp; TYRP1 which were corroborated by our validation study.	Tyrosine	96-99	interleukin 1 beta	Homo sapiens	150-154
27450903-7	2016	In silico target prediction revealed miR-1 targets EDN1, G6PD, HSP60, HSP70, SERP1, SIRT1 &amp; TYR; miR-184 targets EZR &amp; LAMP1; miR-328 targets IL1B, POLH &amp; TRPM1; miR-383 targets EDN1 &amp; TYRP1; and miR-577 targets PTPN22 &amp; TYRP1 which were corroborated by our validation study.	Adenosine Monophosphate	122-125	interleukin 1 beta	Homo sapiens	150-154
27450903-7	2016	In silico target prediction revealed miR-1 targets EDN1, G6PD, HSP60, HSP70, SERP1, SIRT1 &amp; TYR; miR-184 targets EZR &amp; LAMP1; miR-328 targets IL1B, POLH &amp; TRPM1; miR-383 targets EDN1 &amp; TYRP1; and miR-577 targets PTPN22 &amp; TYRP1 which were corroborated by our validation study.	Adenosine Monophosphate	122-125	interleukin 1 beta	Homo sapiens	150-154
27579474-10	2016	Gln treatment of PBMCs overcame PfHz-induced suppression of HSP70 transcripts/protein, reduced NF-kappaB activation, and suppressed over-expression of IL-1beta, IL-6 and TNF-alpha.	Glutamine	0-3	interleukin 1 beta	Homo sapiens	151-159
27579474-10	2016	Gln treatment of PBMCs overcame PfHz-induced suppression of HSP70 transcripts/protein, reduced NF-kappaB activation, and suppressed over-expression of IL-1beta, IL-6 and TNF-alpha.	pfhz	32-36	interleukin 1 beta	Homo sapiens	151-159
27450903-7	2016	In silico target prediction revealed miR-1 targets EDN1, G6PD, HSP60, HSP70, SERP1, SIRT1 &amp; TYR; miR-184 targets EZR &amp; LAMP1; miR-328 targets IL1B, POLH &amp; TRPM1; miR-383 targets EDN1 &amp; TYRP1; and miR-577 targets PTPN22 &amp; TYRP1 which were corroborated by our validation study.	Adenosine Monophosphate	122-125	interleukin 1 beta	Homo sapiens	150-154
27452280-0	2016	Human eosinophils are direct targets to nanoparticles: Zinc oxide nanoparticles (ZnO) delay apoptosis and increase the production of the pro-inflammatory cytokines IL-1beta and IL-8.	Zinc Oxide	55-65	interleukin 1 beta	Homo sapiens	164-172
27206713-0	2016	Synovial fluid proteins are required for the induction of interleukin-1beta production by monosodium urate crystals.	Uric Acid	90-106	interleukin 1 beta	Homo sapiens	58-75
27206713-1	2016	OBJECTIVES: Monosodium urate (MSU) crystal deposition in gouty joints promotes the release of inflammatory mediators, in particular interleukin (IL)-1beta.	Uric Acid	12-28	interleukin 1 beta	Homo sapiens	132-154
27452280-0	2016	Human eosinophils are direct targets to nanoparticles: Zinc oxide nanoparticles (ZnO) delay apoptosis and increase the production of the pro-inflammatory cytokines IL-1beta and IL-8.	Zinc Oxide	81-84	interleukin 1 beta	Homo sapiens	164-172
27452280-7	2016	In addition, ZnO were found to increase the production of the proinflammatory IL-1beta and IL-8 cytokines.	Zinc Oxide	13-16	interleukin 1 beta	Homo sapiens	78-86
27681882-0	2016	Immunomodulatory effects of nicotine on interleukin 1beta activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism.	Nicotine	28-36	interleukin 1 beta	Homo sapiens	40-57
27452280-8	2016	Using a pharmacological approach, we demonstrated that inhibition of caspase-1 reversed the ability of ZnO to induce IL-1beta and IL-8 production, whereas inhibition of caspase-4 only reversed that of IL-8.	Zinc Oxide	103-106	interleukin 1 beta	Homo sapiens	117-125
27681882-4	2016	Here, we investigated the effects of nicotine, an ACh receptor agonist, on the cytokine and cholinesterase production of immunocompetent human astrocytes stimulated with interleukin 1beta (IL-1beta) in vitro.	Nicotine	37-45	interleukin 1 beta	Homo sapiens	170-187
27681882-4	2016	Here, we investigated the effects of nicotine, an ACh receptor agonist, on the cytokine and cholinesterase production of immunocompetent human astrocytes stimulated with interleukin 1beta (IL-1beta) in vitro.	Nicotine	37-45	interleukin 1 beta	Homo sapiens	189-197
27667443-4	2016	Upon treatment with acetate SCFA or FFAR2- and FFAR3-specific synthetic agonists, human monocytes displayed elevated p38 phosphorylation and attenuated C5, CCL1, CCL2, GM-CSF, IL-1alpha, IL-1beta and ICAM-1 inflammatory cytokine expression.	Acetates	20-27	interleukin 1 beta	Homo sapiens	187-195
27681882-11	2016	RESULTS: Nicotine treatment dose dependently limits the production of critical proinflammatory cytokines such as IL-6 (60.5 +- 3.3, %inhibition), IL-1beta (42.4 +- 1.7, %inhibition), and TNF-alpha (68.9 +- 7.7, %inhibition) by activated human astrocytes.	Nicotine	9-17	interleukin 1 beta	Homo sapiens	146-154
27650878-11	2016	Atorvastatin and simvastatin suppressed the DC maturation showing lower expression of CD80, CD83, and CD86, and limited their production of tumor necrosis factor-alpha, IL-1beta and IL-6, and increased transforming growth factor-beta and IL-10 secretion.	Atorvastatin	0-12	interleukin 1 beta	Homo sapiens	169-177
27556861-7	2016	Mechanistic approaches revealed WIN 55,212-2 to suppress IL-1beta-induced TF expression via inhibition of ceramide formation and via decreased phosphorylation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinases.	Ceramides	106-114	interleukin 1 beta	Homo sapiens	57-65
27556861-8	2016	Further inhibitor experiments demonstrated neutral sphingomyelinase (nSMase) to confer ceramide generation upon IL-1beta treatment with the parallel IL-1beta-mediated activation of MAPKs occurring via an nSMase-independent pathway.	Ceramides	87-95	interleukin 1 beta	Homo sapiens	112-120
27296843-3	2016	SMG was either incorporated within the alginate microbeads or used as a secondary coat on poly-l-lysine (PLL)-containing microcapsules, resulting in reduction of the inflammatory cytokines (IL-1beta, TNF, IL-6, IL-8, MIP-1alpha).	N-SUCCINYL METHIONINE	0-3	interleukin 1 beta	Homo sapiens	190-198
27512095-6	2016	Results demonstrated that either IL-1beta or HMGB1 promoted the release of the inflammatory cytokines such as prostaglandin E2 (PGE2), TNF-alpha, IL-6 and IL-8 in human IVD cells.	Dinoprostone	110-126	interleukin 1 beta	Homo sapiens	33-41
27512095-6	2016	Results demonstrated that either IL-1beta or HMGB1 promoted the release of the inflammatory cytokines such as prostaglandin E2 (PGE2), TNF-alpha, IL-6 and IL-8 in human IVD cells.	Dinoprostone	128-132	interleukin 1 beta	Homo sapiens	33-41
27650878-11	2016	Atorvastatin and simvastatin suppressed the DC maturation showing lower expression of CD80, CD83, and CD86, and limited their production of tumor necrosis factor-alpha, IL-1beta and IL-6, and increased transforming growth factor-beta and IL-10 secretion.	Simvastatin	17-28	interleukin 1 beta	Homo sapiens	169-177
27534556-2	2016	IL-1beta secretion that occurs independently of microbial stimulation is typically associated with the presence of endogenous alarmins, such as extracellular ATP (an indicator of cytopathic damage).	Adenosine Triphosphate	158-161	interleukin 1 beta	Homo sapiens	0-8
27609268-10	2016	Furthermore, lycopene decreased LPS-induced expression of IL-1beta and HO-1 in the hippocampus together with decreasing level of IL-6 and TNF-alpha in the plasma.	Lycopene	13-21	interleukin 1 beta	Homo sapiens	58-66
27412645-8	2016	Accordingly, ouabain treatment induces a temporal release of TNF-alpha and IL-1beta from retinal cell cultures.	Ouabain	13-20	interleukin 1 beta	Homo sapiens	75-83
27617025-9	2016	Furthermore we demonstrate in cell culture experiments that Holi colours can induce the production of the pro-inflammatory cytokines TNF-alpha (Tumor necrosis factor-alpha), IL-6 (Interleukine-6) and IL-1beta (Interleukine-1beta).	holi colours	60-72	interleukin 1 beta	Homo sapiens	200-208
27417584-8	2016	In cultured human monocyte-derived macrophages, the p38delta mitogen-activated protein kinase was activated by intracellular stress signals triggered during ATP- and cholesterol crystal-induced NLRP3 inflammasome activation and was required for NLRP3-mediated IL-1beta secretion.	Adenosine Triphosphate	157-160	interleukin 1 beta	Homo sapiens	260-268
27413170-6	2016	Culture of DCs in a biotin-deficient medium (BDM) and subsequent activation with LPS resulted in enhanced secretion of the proinflammatory cytokines TNF-alpha, IL-12p40, IL-23, and IL-1beta compared with LPS-activated DCs cultured in biotin-sufficient (control) and biotin-oversupplemented media.	Biotin	20-26	interleukin 1 beta	Homo sapiens	181-189
27417584-8	2016	In cultured human monocyte-derived macrophages, the p38delta mitogen-activated protein kinase was activated by intracellular stress signals triggered during ATP- and cholesterol crystal-induced NLRP3 inflammasome activation and was required for NLRP3-mediated IL-1beta secretion.	Cholesterol	166-177	interleukin 1 beta	Homo sapiens	260-268
26933897-6	2016	L-Carnitine supplementation decreased serum IL-1beta and MMP-1 levels significantly (p = 0.001 and p = 0.021, respectively); however, serum hs-CRP and MMP-13 levels did not change significantly (p &gt; 0.05).	Carnitine	0-11	interleukin 1 beta	Homo sapiens	44-52
27593484-4	2016	Such decreased pro-IL-1beta expression in TSC1 KO macrophages was rescued by reducing mTORC1 activity with rapamycin or deletion of mTOR.	Sirolimus	107-116	interleukin 1 beta	Homo sapiens	19-27
26547220-5	2016	Pro-inflammatory cytokine IL-1beta, IL-6, and TNF-alpha expressions were significantly higher in the AGA group than in the NAGA or HC group (P &lt; 0.05, respectively).	aga	101-104	interleukin 1 beta	Homo sapiens	26-34
27355133-9	2016	In anti-inflammatory tests, ortho-eugenol inhibited acetic acid induced vascular permeability and leukocyte migration, reducing TNF-alpha and IL-1beta by virtue of its suppression of NF-kappaB and p38 phosphorylated forms in the peritonitis test.	2-Allyl-6-methoxyphenol	28-41	interleukin 1 beta	Homo sapiens	142-150
27208497-1	2016	Acute ethanol intoxication is associated with Rapid Alterations in Neuroimmune Gene Expression (RANGE), including increased Interleukin (IL)-6 and Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha), and suppressed IL-1beta and Tumor necrosis factor (TNF) alpha, yet little is known about adaptations in cytokines across the first few ethanol exposures.	Ethanol	6-13	interleukin 1 beta	Homo sapiens	262-270
27240522-6	2016	GluN2B antagonist ifenprodil showed a wide therapeutic time-window (3days) to reverse the enhanced seizure susceptibility after prolonged FSs or IL-1beta treatment.	ifenprodil	18-28	interleukin 1 beta	Homo sapiens	145-153
26553320-10	2016	Compared with the monoculture, MMP-1, MMP-3, interleukin (IL)-1beta, IL-6, IL-17, and IL-21 in supernatant of cocultures were markedly elevated after treatment with nicotine.	Nicotine	165-173	interleukin 1 beta	Homo sapiens	45-67
28390203-10	2016	The addition of stannous fluoride suppressed production of TNF-a, IFN-g, IL12p70, IL10, IL-1b, IL2, and IL-6, and also increased secretion of Il-8 in dose response fashion.	Tin Fluorides	16-33	interleukin 1 beta	Homo sapiens	88-93
27362973-7	2016	Feeding DHA at weaning, regardless of the suckling diet, resulted in a lower production of IL-1beta and TNF-alpha in LPS-stimulated splenocytes and a higher proportion of total CD27+ cells (all P&lt;.03).	Docosahexaenoic Acids	8-11	interleukin 1 beta	Homo sapiens	91-99
27790461-8	2016	Further, the role of cyclooxygenase - 2, pro-inflammatory cytokines like Tumour Necrosis Factor - alpha, Interleukin - 1beta and free radical scavenging activity (LPO, DPPH and NO) in the action of indazole and its derivatives was investigated using in vitro assays.	Indazoles	198-206	interleukin 1 beta	Homo sapiens	105-124
27362973-10	2016	Feeding a DHA diet during weaning led to a lower TNF-alpha and IL-1beta response to a bacterial antigen.	Docosahexaenoic Acids	10-13	interleukin 1 beta	Homo sapiens	63-71
28598074-5	2016	RESULTS: Compared with the control group,H2O2 not only increased the mRNA and protein expression levels of caspase-1 and NALP3 and the protein expression levels of p-ERK/ERK, but also enhanced the secretion of IL-1beta in human lung epithelial cells A549 (P&lt;0.05),while SF group showed no statistic significance of those indicators above (P&gt;0.05).	Hydrogen Peroxide	41-45	interleukin 1 beta	Homo sapiens	210-218
27484716-0	2016	Celastrol inhibits IL-1beta-induced inflammation in orbital fibroblasts through the suppression of NF-kappaB activity.	celastrol	0-9	interleukin 1 beta	Homo sapiens	19-27
27484716-6	2016	Reverse transcription-polymerase chain reaction, western blotting and ELISAs were performed to examine the effect of celastrol on interleukin (IL)-1beta-induced inflammation in orbital fibroblasts from patients with GO.	celastrol	117-126	interleukin 1 beta	Homo sapiens	130-152
27484716-7	2016	The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2.	celastrol	30-39	interleukin 1 beta	Homo sapiens	180-188
27484716-8	2016	The levels of prostaglandin E2 in orbital fibroblasts induced by IL-1beta were also suppressed by celastrol.	Dinoprostone	14-30	interleukin 1 beta	Homo sapiens	65-73
27484716-8	2016	The levels of prostaglandin E2 in orbital fibroblasts induced by IL-1beta were also suppressed by celastrol.	celastrol	98-107	interleukin 1 beta	Homo sapiens	65-73
27484716-9	2016	Further investigation revealed that celastrol suppressed the IL-1beta-induced inflammatory responses in orbital fibroblasts through inhibiting the activation of nuclear factor (NF)-kappaB.	celastrol	36-45	interleukin 1 beta	Homo sapiens	61-69
27484716-10	2016	Taken together, these results suggested that celastrol attenuated the IL-1beta-induced pro-inflammatory pathway in orbital fibroblasts from patients with GO, which was associated with the suppression of NF-kappaB activation.	celastrol	45-54	interleukin 1 beta	Homo sapiens	70-78
28598074-6	2016	The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P&lt;0.05),when compared with the H2O2 group.	Hydrogen Peroxide	81-85	interleukin 1 beta	Homo sapiens	248-256
28598074-6	2016	The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P&lt;0.05),when compared with the H2O2 group.	Hydrogen Peroxide	81-85	interleukin 1 beta	Homo sapiens	248-256
27117839-7	2016	Taken together, these results highlight a role for melatonin in protecting against TBI-triggered immunopathology, which is accomplished by negatively regulating inflammation activation and IL-1beta secretion via the autophagy of damaged mitochondria.	Melatonin	51-60	interleukin 1 beta	Homo sapiens	189-197
27257938-6	2016	Global HI increased the number of myeloperoxidase positive cells in the mucosa, upregulated mRNA levels of interleukin (IL)-1beta and IL-17 in gut tissue and caused T-cell invasion in the intestinal muscle layer.	hi	7-9	interleukin 1 beta	Homo sapiens	107-129
27355182-8	2016	Peripheral blood mononuclear cells were also stimulated with lipopolysaccharide ex vivo, wherein CCI-induced increases in IL-1beta, nitrite, and IL-10 were suppressed by prior exercise.	CCI	97-100	interleukin 1 beta	Homo sapiens	122-130
27575486-10	2016	Additionally, 15d-PGJ2-SLN increased IL-10 levels and reduced IL-1beta as well as IL-17 in peritoneal fluid.	15d-pgj2-sln	14-26	interleukin 1 beta	Homo sapiens	62-70
29732384-7	2016	Our results indicated that pre-activation of MSCs with IL-1beta resulted in upregulated PGE2 secretion post exposure.	Dinoprostone	88-92	interleukin 1 beta	Homo sapiens	55-63
27652005-8	2016	Increased levels of GGPP and FPP attenuated lipopolysaccharide (LPS)-induced IL-1beta production in THP-1 cells and human PBMCs in statin-treated conditions.	geranylgeranyl pyrophosphate	20-24	interleukin 1 beta	Homo sapiens	77-85
27652005-8	2016	Increased levels of GGPP and FPP attenuated lipopolysaccharide (LPS)-induced IL-1beta production in THP-1 cells and human PBMCs in statin-treated conditions.	farnesyl pyrophosphate	29-32	interleukin 1 beta	Homo sapiens	77-85
27287419-7	2016	Acute AS treatment reduced CCI-induced spinal cord allograft inflammatory factor 1 (known as Iba-1), interleukin-1beta (IL-1beta), and ST2 receptor mRNA expression.	CCI	27-30	interleukin 1 beta	Homo sapiens	101-118
27287419-7	2016	Acute AS treatment reduced CCI-induced spinal cord allograft inflammatory factor 1 (known as Iba-1), interleukin-1beta (IL-1beta), and ST2 receptor mRNA expression.	CCI	27-30	interleukin 1 beta	Homo sapiens	120-128
27287419-8	2016	Chronic AS treatment reduced CCI-induced spinal cord glial fibrillary acidic protein (GFAP), Iba-1, IL-1beta, tumor necrosis factor-alpha (TNF-alpha), interleukin-33 (IL-33) and ST2 mRNA expression.	CCI	29-32	interleukin 1 beta	Homo sapiens	100-108
27544687-9	2016	Although middle cerebral artery occlusion increases the expression of interleukin-1beta and tissue necrosis factor-alpha, this elevation is suppressed by both hypothermia and glycyrrhizin treatment.	Glycyrrhizic Acid	175-187	interleukin 1 beta	Homo sapiens	70-87
27481132-3	2016	They simultaneously up-regulate GPR91, which functions as an autocrine and paracrine sensor for extracellular succinate to enhance IL-1beta production.	Succinic Acid	110-119	interleukin 1 beta	Homo sapiens	131-139
27481132-5	2016	Succinate is abundant in synovial fluids from rheumatoid arthritis (RA) patients, and these fluids elicit IL-1beta release from macrophages in a GPR91-dependent manner.	Succinic Acid	0-9	interleukin 1 beta	Homo sapiens	106-114
27487850-4	2016	Moreover, the combination of LMFHS-Fucox dramatically enhanced the intestinal epithelial barrier and immune function against the lipopolysaccharide effect by inhibiting IL-1beta and TNF-alpha and promoting IL-10 and IFN-gamma.	lmfhs-fucox	29-40	interleukin 1 beta	Homo sapiens	169-177
27297387-7	2016	The inhibition assay showed that CA-074 (a cathepsin B inhibitor), glybenclamide (an NLRP3 molecule inhibitor), and N-benzyloxycarbony-Val-Ala-Asp(O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) reduced the levels of caspase-1 activation and IL-1beta production from THP-1 cells.	n-benzyloxycarbony-val-ala-asp(o-methyl)-fluoromethylketone	116-175	interleukin 1 beta	Homo sapiens	258-266
27242325-6	2016	Pre-incubation with simvastatin prior to treatment with IL-1beta + Oncostatin M decreased the level of CD44 fragmentation, decreased the proportion of CD44 that transits into the lipid raft fractions, decreased ADAM10 activity and diminished the interaction between CD44 and ADAM10.	Simvastatin	20-31	interleukin 1 beta	Homo sapiens	56-64
27337297-9	2016	Cocaine-mediated-increased upregulation of GFAP correlated with increased expression of proinflammatory mediators such as TNF, IL1B, and IL6.	Cocaine	0-7	interleukin 1 beta	Homo sapiens	127-131
27418629-3	2016	METHODS AND RESULTS: In primary hepatocytes from healthy animals, metformin and the IKKbeta (inhibitor of kappa B kinase) inhibitor BI605906 both inhibited tumor necrosis factor-alpha-dependent IkappaB degradation and expression of proinflammatory mediators interleukin-6, interleukin-1beta, and CXCL1/2 (C-X-C motif ligand 1/2).	Metformin	66-75	interleukin 1 beta	Homo sapiens	273-290
27418629-3	2016	METHODS AND RESULTS: In primary hepatocytes from healthy animals, metformin and the IKKbeta (inhibitor of kappa B kinase) inhibitor BI605906 both inhibited tumor necrosis factor-alpha-dependent IkappaB degradation and expression of proinflammatory mediators interleukin-6, interleukin-1beta, and CXCL1/2 (C-X-C motif ligand 1/2).	BI605906	132-140	interleukin 1 beta	Homo sapiens	273-290
27387396-16	2016	In addition, MQEO significantly suppressed LPS-stimulated production of TNF-alpha and IL-1beta, effectively blocked phosphorylation of IKK and IkappaB, and dose-dependently reduced LPS-stimulated expression of TLR4 in THP-1 cells at concentrations ranging from 0.01% to 0.05% (v/v).	mqeo	13-17	interleukin 1 beta	Homo sapiens	86-94
25533354-8	2016	Our results show that high concentrations of PAHs and elemental Ni were strongly associated with high apoptosis rates and high expression of IL-1beta, in addition, Fe element was associated with the ROS level, furthermore, Fe and Cr element were associated with DNA damage in BEAS-2B cells.	Iron	223-225	interleukin 1 beta	Homo sapiens	141-149
25533354-8	2016	Our results show that high concentrations of PAHs and elemental Ni were strongly associated with high apoptosis rates and high expression of IL-1beta, in addition, Fe element was associated with the ROS level, furthermore, Fe and Cr element were associated with DNA damage in BEAS-2B cells.	Polycyclic Aromatic Hydrocarbons	45-49	interleukin 1 beta	Homo sapiens	141-149
27470352-7	2016	RESULTS: It was shown that atorvastatin significantly reduced the expression of NLRP3, the cleavage of caspase-1 and IL-1beta in PMA-induced THP-1 cells.	Atorvastatin	27-39	interleukin 1 beta	Homo sapiens	117-125
27235090-4	2016	Fortepren( ) treatment of patients with a high incidence of recurrent herpes infection led to an increase in the interferon-producing ability of leucocytes stimulated with NDV, as well as in the production of key cytokines (IL-1beta, IL-15, MIP-1alpha, IFN-gamma, IL-12 (p40), TNF-alpha, IFN-alpha2, IL-12 (p70), IL-6) taking part in the protection against viral infection.	fortepren	0-9	interleukin 1 beta	Homo sapiens	224-232
25533354-8	2016	Our results show that high concentrations of PAHs and elemental Ni were strongly associated with high apoptosis rates and high expression of IL-1beta, in addition, Fe element was associated with the ROS level, furthermore, Fe and Cr element were associated with DNA damage in BEAS-2B cells.	Iron	164-166	interleukin 1 beta	Homo sapiens	141-149
25533354-8	2016	Our results show that high concentrations of PAHs and elemental Ni were strongly associated with high apoptosis rates and high expression of IL-1beta, in addition, Fe element was associated with the ROS level, furthermore, Fe and Cr element were associated with DNA damage in BEAS-2B cells.	Chromium	230-232	interleukin 1 beta	Homo sapiens	141-149
27167582-15	2016	Multivariate regression analysis of all recruited individuals demonstrated a significant positive association between DNA methylation and folate (p=0.013), creatinine (p=0.003) concentrations and IL1B-511T (p=0.002) and PON1 192R (p=0.049) alleles and negative association with fasting glucose (p=0.004).	Glucose	286-293	interleukin 1 beta	Homo sapiens	196-200
27271323-7	2016	Western blot analysis showed that melatonin inhibited p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK) phosphorylation, and IkB-alpha degradation and phosphorylation in IL-1beta-stimulated HPDLC.	Melatonin	34-43	interleukin 1 beta	Homo sapiens	198-206
27043920-12	2016	In addition, baicalin also inhibited the productions of inflammatory cytokines such as IL-1beta, IL-6, IL-8 and TNF-alpha and suppressed the phosphorylation of JAK2, STAT5, IKKbeta, IkappaBalpha and the nuclear translocation of NF-kappaB (p65) subunit in LPS-stimulated human mast cells.	baicalin	13-21	interleukin 1 beta	Homo sapiens	87-95
27056390-10	2016	In OA human chondrocytes, we demonstrated that RvD1 was not toxic up to 10 muM and stifled IL-1beta-induced cyclooxygenase 2, prostaglandin E2, inducible nitric oxide synthase, nitric oxide, and matrix metalloproteinase-13.	Nitric Oxide	154-166	interleukin 1 beta	Homo sapiens	91-99
27271323-0	2016	Melatonin Inhibits CXCL10 and MMP-1 Production in IL-1beta-Stimulated Human Periodontal Ligament Cells.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	50-58
27271323-6	2016	Melatonin decreased CXCL10 and MMP-1 production and increased TIMP-1 production in IL-1beta-stimulated HPDLC.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	83-91
27312705-5	2016	First, NS-398, instead of reducing inflammation, appeared to further enhance IL-1beta-mediated COX-2 and IL-8 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	7-13	interleukin 1 beta	Homo sapiens	77-85
27294276-5	2016	Our results showed that coptisine greatly inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2), as well as suppressed the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in human OA chondrocytes induced by IL-1beta.	coptisine	24-33	interleukin 1 beta	Homo sapiens	251-259
27294276-3	2016	However, the anti-inflammatory effects of coptisine on interleukin-1 beta (IL-1beta)-stimulated chondrocytes have not been reported.	coptisine	42-51	interleukin 1 beta	Homo sapiens	55-73
27294276-3	2016	However, the anti-inflammatory effects of coptisine on interleukin-1 beta (IL-1beta)-stimulated chondrocytes have not been reported.	coptisine	42-51	interleukin 1 beta	Homo sapiens	75-83
27294276-4	2016	Therefore, the aim of this study was to investigate the effects of coptisine on IL-1beta-induced inflammation in human articular chondrocytes.	coptisine	67-76	interleukin 1 beta	Homo sapiens	80-88
27294276-7	2016	Furthermore, coptisine significantly inhibited the IL-1beta-induced NF-kB activation in human OA chondrocytes.	coptisine	13-22	interleukin 1 beta	Homo sapiens	51-59
27312705-7	2016	NS-398 also promoted IL-1beta-mediated NF-kappaB p65 nuclear translocation but had no effect on IL-1beta-activated MAPK phosphorylation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	21-29
27294276-8	2016	Taken together, these data suggest that coptisine inhibits the IL-1beta-induced inflammatory response by suppressing the NF-kB signaling pathway.	coptisine	40-49	interleukin 1 beta	Homo sapiens	63-71
27312705-9	2016	Our findings demonstrate a clear pro-inflammatory function for NS-398 in the IL-1beta-mediated inflammatory response of granulosa cells, at least in part, owing to its augmenting effect on the IL-1beta-induced activation of NF-kappaB.	Nitrogen	63-65	interleukin 1 beta	Homo sapiens	77-85
27312705-0	2016	Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1beta-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	58-64	interleukin 1 beta	Homo sapiens	68-76
27312705-4	2016	Here we have investigated the action of NS-398 using a human ovarian granulosa cell line, KGN, by exploring IL-1beta-regulated COX-2 and IL-8 expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	40-46	interleukin 1 beta	Homo sapiens	108-116
27312705-9	2016	Our findings demonstrate a clear pro-inflammatory function for NS-398 in the IL-1beta-mediated inflammatory response of granulosa cells, at least in part, owing to its augmenting effect on the IL-1beta-induced activation of NF-kappaB.	Nitrogen	63-65	interleukin 1 beta	Homo sapiens	193-201
27027581-8	2016	Real-time PCR analysis revealed the mRNA levels of IL-1beta, tumor necrosis factor-alpha, and matrix metalloproteinase-3 were down-regulated significantly (all p &lt; 0.05) when FLSs cultured in HA or HA + GSH.	Glutathione	206-209	interleukin 1 beta	Homo sapiens	51-59
27494347-7	2016	Protocatechuic aldehyde attenuated TNF-alpha and IL-1beta-induced hyaluronan production.	Aldehydes	15-23	interleukin 1 beta	Homo sapiens	49-57
27494347-7	2016	Protocatechuic aldehyde attenuated TNF-alpha and IL-1beta-induced hyaluronan production.	Hyaluronic Acid	66-76	interleukin 1 beta	Homo sapiens	49-57
27027581-10	2016	In addition, the protein levels of IL-1beta were further decreased with significant differences (both p &lt; 0.05) in the HA + 10% GSH and HA + 20% GSH groups when compared to FLSs cultured in normal medium.	Glutathione	131-134	interleukin 1 beta	Homo sapiens	35-43
27027581-10	2016	In addition, the protein levels of IL-1beta were further decreased with significant differences (both p &lt; 0.05) in the HA + 10% GSH and HA + 20% GSH groups when compared to FLSs cultured in normal medium.	Glutathione	148-151	interleukin 1 beta	Homo sapiens	35-43
27234962-7	2016	Furthermore, treatment with 24,25-[OH]2D3 increased IL-1beta, IL-6, and IL-8 expression by HepG2 cells.	24,25-Dihydroxyvitamin D 3	28-41	interleukin 1 beta	Homo sapiens	52-60
27142572-8	2016	Purified cell wall polysaccharides of A. nidulans induced a much higher level of IL-1beta secretion by CGD PBMCs than did cell wall polysaccharides isolated from A. fumigatus.	Polysaccharides	19-34	interleukin 1 beta	Homo sapiens	81-89
27063995-10	2016	A significant redundant interaction between IL1B +3954 C/T and FCGR2A 131His/Arg was observed.	131his	70-76	interleukin 1 beta	Homo sapiens	44-48
26447636-5	2016	RESULTS: Gingival crevicular fluid levels of IL-1beta were significantly elevated in the CTG group at 10 d compared with baseline (p &lt; 0.05).	ctg	89-92	interleukin 1 beta	Homo sapiens	45-53
27063995-10	2016	A significant redundant interaction between IL1B +3954 C/T and FCGR2A 131His/Arg was observed.	Arginine	77-80	interleukin 1 beta	Homo sapiens	44-48
27300134-12	2016	In addition, palmitic acid-induced IL-1beta, IL-6, and IL-8 secretion was depended on reactive oxygen species (ROS) generation.	Reactive Oxygen Species	86-109	interleukin 1 beta	Homo sapiens	35-43
27300134-12	2016	In addition, palmitic acid-induced IL-1beta, IL-6, and IL-8 secretion was depended on reactive oxygen species (ROS) generation.	Reactive Oxygen Species	111-114	interleukin 1 beta	Homo sapiens	35-43
27300134-0	2016	Palmitic acid induces interleukin-1beta secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.	Palmitic Acid	0-13	interleukin 1 beta	Homo sapiens	22-39
27300134-13	2016	In conclusion, palmitic acid caused activation of NLRP3 inflammasomes and inflammatory responses, inducing IL-1beta, IL-6, and IL-8 secretion, which is associated with ROS generation, in human Sw.71 placental cells.	Palmitic Acid	15-28	interleukin 1 beta	Homo sapiens	107-115
27300134-7	2016	Palmitic acid stimulated caspase-1 activation and markedly increased interleukin (IL)-1beta secretion in Sw.71 cells.	Palmitic Acid	0-13	interleukin 1 beta	Homo sapiens	69-91
27300134-8	2016	Treatment with a caspase-1 inhibitor diminished palmitic acid-induced IL-1beta release.	Palmitic Acid	48-61	interleukin 1 beta	Homo sapiens	70-78
27372869-4	2016	IL-1beta was found to stimulate the secretion of antidiuretic hormone (ADH) from the posterior pituitary gland either by action of prostaglandins or indirectly by causing the release of IL-6.	Prostaglandins	131-145	interleukin 1 beta	Homo sapiens	0-8
27300134-9	2016	In addition, NLRP3 and caspase-1 genome editing using a CRISPR/Cas9 system in Sw.71 cells suppressed IL-1beta secretion, which was stimulated by palmitic acid.	Palmitic Acid	145-158	interleukin 1 beta	Homo sapiens	101-109
27300134-12	2016	In addition, palmitic acid-induced IL-1beta, IL-6, and IL-8 secretion was depended on reactive oxygen species (ROS) generation.	Palmitic Acid	13-26	interleukin 1 beta	Homo sapiens	35-43
27373423-8	2016	Moreover, cynaropicrin not only suppressed TNF-alpha stimulation, it had a similar effect on IL-1beta stimulation.	cynaropicrin	10-22	interleukin 1 beta	Homo sapiens	93-101
27314600-6	2016	Treatment with rhBNP (0.1 microM) reduced the production of IL-1beta at the protein and mRNA levels.	rhbnp	15-20	interleukin 1 beta	Homo sapiens	60-68
27314600-8	2016	However, the JNK inhibitor, SP600125, significantly inhibited LPS-induced IL-1beta production.	pyrazolanthrone	28-36	interleukin 1 beta	Homo sapiens	74-82
27199075-5	2016	RESULTS: Culture with tumour necrosis factor and interleukin-1beta increased airway narrowing to acetylcholine but did not affect the bronchodilatory response to DI.	Acetylcholine	97-110	interleukin 1 beta	Homo sapiens	49-66
27344616-8	2016	The stimulating and inhibitory effects of TGF-beta were reproduced in IL-1beta-stimulated PG production.	Prostaglandins	90-92	interleukin 1 beta	Homo sapiens	70-78
27181326-6	2016	10mg/Kg indomethacin pretreatment on the duration of the LCR, and in the same animals we also examined the duration of the LCR when body temperature was elevated approximately 2 C. We found that IL-1beta significantly increased the duration of the LCR even when body temperature was held constant.	Indomethacin	8-20	interleukin 1 beta	Homo sapiens	195-203
27181326-8	2016	The effects of IL-1beta, but not elevated body temperature, were blocked by pretreatment with indomethacin alone.	Indomethacin	94-106	interleukin 1 beta	Homo sapiens	15-23
27096899-2	2016	Upon lipopolysaccharide (LPS) triggering of toll-like receptor (TLR)-4 and subsequent ATP signaling, the NOD-like receptor containing-pyrin domain 3 (NLRP3) inflammasome is activated to cleave pro-caspase-1 into caspase-1, allowing the secretion of IL-1beta.	Adenosine Triphosphate	86-89	interleukin 1 beta	Homo sapiens	249-257
27438413-6	2016	Inhibiting subretinal MP accumulation or Il-1beta might protect the CS and help preserve high acuity daytime vision in conditions characterized by subretinal inflammation, such as AMD and RP.	Cesium	68-70	interleukin 1 beta	Homo sapiens	41-49
27288094-5	2016	Furthermore, PFOS inhibited the reduction of IL-6 and IL-1beta, the key proinflammatory cytokines in maternal-fetal immune intolerance, by cortisone in the decidual stromal cells indicating attenuated conversion of cortisone to cortisol.	perfluorooctane sulfonic acid	13-17	interleukin 1 beta	Homo sapiens	54-62
27288094-5	2016	Furthermore, PFOS inhibited the reduction of IL-6 and IL-1beta, the key proinflammatory cytokines in maternal-fetal immune intolerance, by cortisone in the decidual stromal cells indicating attenuated conversion of cortisone to cortisol.	Cortisone	139-148	interleukin 1 beta	Homo sapiens	54-62
27501764-7	2016	Additionally, taurine zinc SDs downregulated the expression of interleukin-1beta and inhibited the phosphorylation of Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase2 (ERK2) in the liver after bile duct ligation.	taurine zinc sds	14-30	interleukin 1 beta	Homo sapiens	63-80
27133574-7	2016	On the contrary, administration of recombinant human IL-1beta weakens the efficacy of diazepam by prolonging its latency to terminate non-prolonged SE.	Diazepam	86-94	interleukin 1 beta	Homo sapiens	53-61
27181326-13	2016	This sensitization is likely initiated by cyclo-oxygenase-2 dependent synthesis of prostaglandin E2, which is stimulated by elevated levels of IL-1beta or IL-6.	Dinoprostone	83-99	interleukin 1 beta	Homo sapiens	143-151
27196743-9	2016	The results showed that the HMGB1A/heparin complex reduced pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1beta, more effectively than HMGB1A or heparin alone.	Heparin	35-42	interleukin 1 beta	Homo sapiens	164-172
27421015-7	2016	Quercetin suppressed the secretion of tumor necrosis factor-a, interleukin (IL)-1b, and IL-6 in LPS-stimulated human PBMCs.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	63-82
27381056-0	2016	Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1beta via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	64-72
27415000-11	2016	Importantly, stimulated expression of IL-1beta and IL-8 in HaCaT-TNF-alpha were blocked by Quercetin, a flavanol shown to possess anti-TNF-alpha activities.	Quercetin	91-100	interleukin 1 beta	Homo sapiens	38-46
27415000-11	2016	Importantly, stimulated expression of IL-1beta and IL-8 in HaCaT-TNF-alpha were blocked by Quercetin, a flavanol shown to possess anti-TNF-alpha activities.	flavanol	104-112	interleukin 1 beta	Homo sapiens	38-46
27385120-4	2016	Conversely, HCV particles are detected by macrophages, but not by monocytes and DCs, through a TLR7/8 dependent mechanism; this leads to chloroquine sensitive production of pro-inflammatory cytokines including IL-1beta, while the antiviral type I Interferon response is not triggered in these cells.	Chloroquine	137-148	interleukin 1 beta	Homo sapiens	210-218
27381056-3	2016	The present study showed that repeated intraperitoneal injection of curcumin ameliorated SNI-induced mechanical and cold allodynia in a dose-dependent manner and inhibited the elevation of spinal mature IL-1beta protein levels.	Curcumin	68-76	interleukin 1 beta	Homo sapiens	203-211
27381056-3	2016	The present study showed that repeated intraperitoneal injection of curcumin ameliorated SNI-induced mechanical and cold allodynia in a dose-dependent manner and inhibited the elevation of spinal mature IL-1beta protein levels.	sni	89-92	interleukin 1 beta	Homo sapiens	203-211
27381056-5	2016	Furthermore, the genetic down-regulation of NALP1 inflammasome activation by NALP1 siRNA and the pharmacological inhibition of the JAK2-STAT3 cascade by AG490 markedly inhibited IL-1beta maturation and Pro-IL-1beta synthesis, respectively, and reduced SNI-induced pain hypersensitivity.	sni	252-255	interleukin 1 beta	Homo sapiens	178-186
27381056-6	2016	Our results suggest that curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1beta by inhibiting the aggregation of NALP1 inflammasome and the activation of the JAK2-STAT3 cascade in astrocytes.	Curcumin	25-33	interleukin 1 beta	Homo sapiens	113-121
27327525-7	2016	Moreover, addition of Gas6 significantly suppressed silica induced TNF-alpha, IL-1beta and IL-6 levels in negative dose-dependent manners, not only in mRNA levels but also in protein levels.	Silicon Dioxide	52-58	interleukin 1 beta	Homo sapiens	78-86
26546554-10	2016	Furthermore, aluminum altered TNFalpha, IL1beta, IL6, and IL10 mRNA levels as well.	Aluminum	13-21	interleukin 1 beta	Homo sapiens	40-47
27038916-6	2016	The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles.	Quercetin	177-186	interleukin 1 beta	Homo sapiens	74-92
27038916-6	2016	The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles.	Silicon Dioxide	194-200	interleukin 1 beta	Homo sapiens	74-92
27038016-11	2016	Moreover, sodium nitrite significantly elevated TNF-alpha, IL-1beta, IL-6, caspase-3 and reduced Nrf2.	Sodium Nitrite	10-24	interleukin 1 beta	Homo sapiens	59-67
27317992-4	2016	Mechanism study showed that dioscin significantly decreased the expression levels of IL-1beta, IL-6, TNF-alpha, IkappaBalpha, p50 and p65 through regulating TLR4/MyD88 pathway to rehabilitate inflammation.	dioscin	28-35	interleukin 1 beta	Homo sapiens	85-93
27508230-5	2016	The data are supplemental to our original research article reporting detailed analysis of the actions of Aminaphtone on IL-1beta stimulated endothelial cells at the molecular level, "Gene expression profiling reveals novel protective effects of Aminaphtone on ECV304 endothelial cells" (Salazar et al., 2016) [1].	aminaftone	105-116	interleukin 1 beta	Homo sapiens	120-128
27508230-5	2016	The data are supplemental to our original research article reporting detailed analysis of the actions of Aminaphtone on IL-1beta stimulated endothelial cells at the molecular level, "Gene expression profiling reveals novel protective effects of Aminaphtone on ECV304 endothelial cells" (Salazar et al., 2016) [1].	aminaftone	245-256	interleukin 1 beta	Homo sapiens	120-128
26593276-5	2016	We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1).	Lithium Chloride	14-30	interleukin 1 beta	Homo sapiens	247-264
26593276-5	2016	We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1).	Lithium Chloride	32-36	interleukin 1 beta	Homo sapiens	247-264
27129183-7	2016	IL-1beta secretion increased by 580.4% (P&lt;0.01) in ACS patients compared with controls but only with ATP stimulation.	Adenosine Triphosphate	104-107	interleukin 1 beta	Homo sapiens	0-8
27129183-9	2016	Colchicine treatment in ACS patients markedly reduced intracellular and secreted levels of IL-1beta compared with pre-treatment levels (P&lt;0.05 for both), as well as significantly reducing pro-caspase-1 mRNA levels by 57.7% and secreted caspase-1 protein levels by 30.2% compared with untreated patients (P&lt;0.05 for both).	Colchicine	0-10	interleukin 1 beta	Homo sapiens	91-99
27129183-10	2016	Monocytes from ACS patients are "primed" to secrete inflammasome-related cytokines and short-term colchicine acutely and markedly suppresses monocyte caspase-1 activity, thereby reducing monocyte secretion of IL-1beta.	Colchicine	98-108	interleukin 1 beta	Homo sapiens	209-217
26705388-7	2016	Cholesterol crystals initiate inflammation via NLRP3 inflammasome leading to interleukin-1beta (IL-1beta) production inducing C-reactive protein.	Cholesterol	0-11	interleukin 1 beta	Homo sapiens	77-94
26705388-7	2016	Cholesterol crystals initiate inflammation via NLRP3 inflammasome leading to interleukin-1beta (IL-1beta) production inducing C-reactive protein.	Cholesterol	0-11	interleukin 1 beta	Homo sapiens	96-104
27224660-7	2016	Our results showed that ginsenoside Rf significantly reduced the production of IL-1beta, IL-6, TNF-alpha, NO, and ROS, which are most highly activated in IBD.	ginsenoside Rf	24-38	interleukin 1 beta	Homo sapiens	79-87
27219123-1	2016	INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18.	Uric Acid	87-103	interleukin 1 beta	Homo sapiens	223-231
26851450-8	2016	The basal and IL1beta-stimulated glucose transport was monitored by the entrance of (3)[H]2-deoxyglucose in chondrocytes.	Glucose	33-40	interleukin 1 beta	Homo sapiens	14-21
27219123-1	2016	INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18.	Uric Acid	105-108	interleukin 1 beta	Homo sapiens	223-231
27200471-0	2016	Inhibition of TNF-alpha, IL-1alpha, and IL-1beta by Pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR Agonists In Vitro.	vitamin MK 7	108-121	interleukin 1 beta	Homo sapiens	40-48
27200471-8	2016	MK-7 is able to modulate immune and inflammatory reactions in the dose-response inhibition of TNF-alpha, IL-1alpha, and IL-1beta gene expression and protein production by the healthy hMDMs in vitro.	vitamin MK 7	0-4	interleukin 1 beta	Homo sapiens	120-128
27011369-0	2016	The presence of heparins during decidualization modulates the response of human endometrial stromal cells to IL-1beta in vitro.	Heparin	16-24	interleukin 1 beta	Homo sapiens	109-117
27011369-1	2016	PURPOSE: The aim of this paper is to study the impact of heparin on the response of human endometrial stromal cells (ESCs) to interleukin (IL)-1beta during decidualization in vitro.	Heparin	57-64	interleukin 1 beta	Homo sapiens	126-148
27011369-6	2016	Unfractionated heparin as well as tinzaparin attenuated the IL-1beta-mediated induction of IL-6, IL-11, and LIF on protein and messenger RNA (mRNA) levels.	Heparin	15-22	interleukin 1 beta	Homo sapiens	60-68
27011369-6	2016	Unfractionated heparin as well as tinzaparin attenuated the IL-1beta-mediated induction of IL-6, IL-11, and LIF on protein and messenger RNA (mRNA) levels.	Tinzaparin	34-44	interleukin 1 beta	Homo sapiens	60-68
27011369-8	2016	CONCLUSIONS: Unfractionated heparin and the low molecular weight heparin tinzaparin have modulating effects on IL-1beta-induced endometrial cytokines of the IL-6 family during decidualization.	Heparin	28-35	interleukin 1 beta	Homo sapiens	111-119
27011369-8	2016	CONCLUSIONS: Unfractionated heparin and the low molecular weight heparin tinzaparin have modulating effects on IL-1beta-induced endometrial cytokines of the IL-6 family during decidualization.	Heparin	65-72	interleukin 1 beta	Homo sapiens	111-119
26851450-8	2016	The basal and IL1beta-stimulated glucose transport was monitored by the entrance of (3)[H]2-deoxyglucose in chondrocytes.	(3)[h]2-deoxyglucose	84-104	interleukin 1 beta	Homo sapiens	14-21
26851450-11	2016	SSAO inhibition delayed the late stage of chondrocyte differentiation without cell survival alteration and diminished the basal and IL1beta-stimulated glucose transport.	Glucose	151-158	interleukin 1 beta	Homo sapiens	132-139
27349288-1	2016	We demonstrated previously that phosphocholine and phosphocholine-modified macromolecules efficiently inhibit ATP-dependent release of interleukin-1beta from human and murine monocytes by a mechanism involving nicotinic acetylcholine receptors (nAChR).	Phosphorylcholine	32-46	interleukin 1 beta	Homo sapiens	135-152
26959386-0	2016	Trichomonas vaginalis induces IL-1beta production in a human prostate epithelial cell line by activating the NLRP3 inflammasome via reactive oxygen species and potassium ion efflux.	Reactive Oxygen Species	132-155	interleukin 1 beta	Homo sapiens	30-38
26959386-0	2016	Trichomonas vaginalis induces IL-1beta production in a human prostate epithelial cell line by activating the NLRP3 inflammasome via reactive oxygen species and potassium ion efflux.	Potassium	160-169	interleukin 1 beta	Homo sapiens	30-38
26959386-12	2016	The NADPH oxidase inhibitor DPI and high extracellular potassium ion suppressed the production of IL-1beta, caspase-1, and the expression of NLRP3 and ASC proteins.	3-aminodiphenyleneiodium	28-31	interleukin 1 beta	Homo sapiens	98-106
26959386-12	2016	The NADPH oxidase inhibitor DPI and high extracellular potassium ion suppressed the production of IL-1beta, caspase-1, and the expression of NLRP3 and ASC proteins.	Potassium	55-64	interleukin 1 beta	Homo sapiens	98-106
26959386-13	2016	The specific NF-kappaB inhibitor, Bay 11-7082, inhibited IL-1beta production, and also inhibited the production of caspase-1, ASC and NLRP3 proteins.	3-(4-methylphenylsulfonyl)-2-propenenitrile	34-45	interleukin 1 beta	Homo sapiens	57-65
27320908-5	2016	In lung cancer patients, plasma IL-1beta levels correlated with poor prognosis, and IL-1beta increased following bortezomib treatment.	Bortezomib	113-123	interleukin 1 beta	Homo sapiens	84-92
27349288-1	2016	We demonstrated previously that phosphocholine and phosphocholine-modified macromolecules efficiently inhibit ATP-dependent release of interleukin-1beta from human and murine monocytes by a mechanism involving nicotinic acetylcholine receptors (nAChR).	Phosphorylcholine	51-65	interleukin 1 beta	Homo sapiens	135-152
27349288-1	2016	We demonstrated previously that phosphocholine and phosphocholine-modified macromolecules efficiently inhibit ATP-dependent release of interleukin-1beta from human and murine monocytes by a mechanism involving nicotinic acetylcholine receptors (nAChR).	Adenosine Triphosphate	110-113	interleukin 1 beta	Homo sapiens	135-152
27313839-6	2016	RESULTS: ESE-1 and COX-2 were induced by IL-1beta in RASFs that corresponded with an increase in PGE2.	Dinoprostone	97-101	interleukin 1 beta	Homo sapiens	41-49
27321752-2	2016	In human inflammasome PCR array, among different involved in inflammasome formation, in HIV infected macrophages in the presence of cocaine, we have observed significant upregulation of NLRP3, AIM2 genes and downstream genes IL-1beta and PTGS2.	Cocaine	132-139	interleukin 1 beta	Homo sapiens	225-233
27321752-8	2016	These results indicate that in case of HIV infected macrophages exposed to cocaine, increased ROS production and IL-1beta transcription serve as an activators for the formation of NLRP3 and AIM2 mediated inflammasomes that leads to caspase 1 mediated apoptosis.	Cocaine	75-82	interleukin 1 beta	Homo sapiens	113-121
27308826-10	2016	Interestingly, there was a mean increase in all inflammatory cytokines (IL-1beta, IL-6, and IL-8) during the saline treatment from day 1 to week 3, whereas during the Tyloxapol treatment, all cytokines decreased.	Sodium Chloride	109-115	interleukin 1 beta	Homo sapiens	72-80
27393034-0	2016	Carbon monoxide releasing molecule-2 ameliorates IL-1beta-induced IL-8 in human gastric cancer cells.	Carbon Monoxide	0-15	interleukin 1 beta	Homo sapiens	49-57
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	rosmarinic acid	14-16	interleukin 1 beta	Homo sapiens	106-114
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	41-50	interleukin 1 beta	Homo sapiens	106-114
27210890-8	2016	In addition, RA significantly inhibited poly(I:C)-induced inflammasome activation, in terms of secretion of active form of IL-1beta and caspase-1.	rosmarinic acid	13-15	interleukin 1 beta	Homo sapiens	123-131
27210890-8	2016	In addition, RA significantly inhibited poly(I:C)-induced inflammasome activation, in terms of secretion of active form of IL-1beta and caspase-1.	Poly I-C	40-49	interleukin 1 beta	Homo sapiens	123-131
27227459-4	2016	The oral administration of MG (7 mg/kg) attenuates arthritis induced by zymosan, affecting edema formation, leukocyte migration, and the production of inflammatory mediators (IL-1beta, IL-6, TNF-alpha, CXCL-1, LTB4, and PGE2).	methyl gallate	27-29	interleukin 1 beta	Homo sapiens	175-183
27393034-6	2016	IL-1beta induced the translocation of p47(phox) to activate reactive oxygen species (ROS)-producing NADPH oxidase (NOX).	Reactive Oxygen Species	60-83	interleukin 1 beta	Homo sapiens	0-8
27393034-6	2016	IL-1beta induced the translocation of p47(phox) to activate reactive oxygen species (ROS)-producing NADPH oxidase (NOX).	Reactive Oxygen Species	85-88	interleukin 1 beta	Homo sapiens	0-8
27393034-8	2016	Pharmacological inhibition and mutagenesis studies indicated that NOX, ROS, Erk1/2, and p38 MAPK are involved in IL-1beta-induced IL-8 expression.	Reactive Oxygen Species	71-74	interleukin 1 beta	Homo sapiens	113-121
27393034-11	2016	CORM-2 pretreatment significantly mitigated IL-1beta-induced activation of ROS/NF-kB and Erk1/2/AP-1 cascades, blocking IL-8 expression and thus significantly reducing endothelial cell proliferation in the tumor microenvironment.	Reactive Oxygen Species	75-78	interleukin 1 beta	Homo sapiens	44-52
27155490-4	2016	In human THP-1 myeloid cells, wild-type and NLRP3-deficient, both aluminum oxyhydroxide nanoparticles and microparticles stimulate the secretion of proinflammatory cytokine IL-1beta by activating NLRP3 inflammasome, although aluminum oxyhydroxide nanoparticles are more potent than microparticles, likely related to the higher uptake of the nanoparticles by the THP-1 cells than the microparticles.	Boehmite	225-246	interleukin 1 beta	Homo sapiens	173-181
27155490-4	2016	In human THP-1 myeloid cells, wild-type and NLRP3-deficient, both aluminum oxyhydroxide nanoparticles and microparticles stimulate the secretion of proinflammatory cytokine IL-1beta by activating NLRP3 inflammasome, although aluminum oxyhydroxide nanoparticles are more potent than microparticles, likely related to the higher uptake of the nanoparticles by the THP-1 cells than the microparticles.	Boehmite	66-87	interleukin 1 beta	Homo sapiens	173-181
27102438-6	2016	Furthermore, wogonoside dramatically decreased the secretion and expression of IL-1beta, IL-6 and TNF-alpha as well as the nuclear expression of NF-kappaB in adenomas and surrounding tissues.	wogonoside	13-23	interleukin 1 beta	Homo sapiens	79-87
27278808-10	2016	Z-MWCNTs released Zn(+2) ions in media and increased IL-6, IL-1beta, CXCL10, and TNF-alpha mRNAs in THP-1 cells in vitro.	z-mwcnts	0-8	interleukin 1 beta	Homo sapiens	59-67
27103438-5	2016	Ro5-4864 efficiently attenuated NLRP3 translocation to mitochondria, inflammasome assembly/oligomerization, activation of caspase-1, and subsequent secretion of the mature forms of interleukin-1beta and -18.	4'-chlorodiazepam	0-8	interleukin 1 beta	Homo sapiens	181-198
26997368-8	2016	Our results showed that SchA inhibited IL-1beta-induced NO, PGE2, and TNF-alpha production in a dose-dependent manner.	Dinoprostone	60-64	interleukin 1 beta	Homo sapiens	39-47
27622485-0	2016	Dendritic cells generated in the presence of vitamin D3 and stimulated with lipopolysaccharide secrete IL-8, IL-1beta, IL-10 and induce relatively low levels of CD4+CD25hiFoxp3+ T cells.	Cholecalciferol	45-55	interleukin 1 beta	Homo sapiens	109-117
27199127-8	2016	Sitagliptin treatment improved cardiac function and perfusion, reduced macrophage infiltration, and diminished the levels of inflammatory biomarkers including TNF-alpha, IL-1beta, and CCL2.	Sitagliptin Phosphate	0-11	interleukin 1 beta	Homo sapiens	170-178
27056727-9	2016	Hydrocortisone significantly attenuated IL-1beta-induced inflammatory responses in the immature human gut when administered at the time of the proinflammatory insult: IL-1beta-induced IL-8 and IL-6 secretion in the fetal ileum as well as H4 cells were significantly reduced.	Hydrocortisone	0-14	interleukin 1 beta	Homo sapiens	40-48
27056727-9	2016	Hydrocortisone significantly attenuated IL-1beta-induced inflammatory responses in the immature human gut when administered at the time of the proinflammatory insult: IL-1beta-induced IL-8 and IL-6 secretion in the fetal ileum as well as H4 cells were significantly reduced.	Hydrocortisone	0-14	interleukin 1 beta	Homo sapiens	167-175
26895538-8	2016	Taken together, the elevated Pb levels result in the lower percentages of NK cells, but also alter the levels of platelets, IL-1beta and IL-27, which might be unconducive to the activity and function of NK cells.	Lead	29-31	interleukin 1 beta	Homo sapiens	124-132
26971407-9	2016	The combination of IL-1beta and already used therapies, i.e. IFNalpha or tenofovir, demonstrated a stronger or similar anti-HBV activity.	Tenofovir	73-82	interleukin 1 beta	Homo sapiens	19-27
27473957-7	2016	Our results indicated that the isoquercitrin treatment of PMACI-stimulated KU812 cells significantly reduced the production of histamine and the pro-inflammatory cytokines, such as interleukin (IL)-6, IL-8, IL-1beta, and tumor necrosis factor (TNF)-alpha.	isoquercitrin	31-44	interleukin 1 beta	Homo sapiens	207-215
27473957-7	2016	Our results indicated that the isoquercitrin treatment of PMACI-stimulated KU812 cells significantly reduced the production of histamine and the pro-inflammatory cytokines, such as interleukin (IL)-6, IL-8, IL-1beta, and tumor necrosis factor (TNF)-alpha.	pmaci	58-63	interleukin 1 beta	Homo sapiens	207-215
27102898-0	2016	Tormentic Acid Inhibits IL-1beta-Induced Inflammatory Response in Human Osteoarthritic Chondrocytes.	euscaphic acid	0-14	interleukin 1 beta	Homo sapiens	24-32
26155780-2	2016	In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1beta-stimulated SK-N-SH cells.	Dinoprostone	83-87	interleukin 1 beta	Homo sapiens	102-110
26155780-3	2016	METHODS: An enzyme immunoassay (EIA) was used to measure prostaglandin E2 (PGE2) production from supernatants of IL-1beta-stimulated SK-N-SH cells.	Dinoprostone	57-73	interleukin 1 beta	Homo sapiens	113-121
26155780-3	2016	METHODS: An enzyme immunoassay (EIA) was used to measure prostaglandin E2 (PGE2) production from supernatants of IL-1beta-stimulated SK-N-SH cells.	Dinoprostone	75-79	interleukin 1 beta	Homo sapiens	113-121
26155780-6	2016	RESULTS: PWE (25-200 mug/ml) dose dependently reduced COX-2-dependent PGE2 production in SK-N-SH cells stimulated with IL-1beta.	Dinoprostone	70-74	interleukin 1 beta	Homo sapiens	119-127
26894419-0	2016	The association between phthalate exposure and atopic dermatitis with a discussion of phthalate induced secretion of interleukin-1beta and thymic stromal lymphopoietin.	phthalic acid	24-33	interleukin 1 beta	Homo sapiens	117-134
26894419-0	2016	The association between phthalate exposure and atopic dermatitis with a discussion of phthalate induced secretion of interleukin-1beta and thymic stromal lymphopoietin.	phthalic acid	86-95	interleukin 1 beta	Homo sapiens	117-134
27016717-3	2016	Caco-2 cells grown in medium chain fatty acids enriched medium has exaggerated t-butyl hydroperoxide induced cell damage, GSH depletion, and IL-1beta induced IL-8 synthesis, compared to the cells grown in oleic acid &amp; hydroxytyrosol (OT) enriched medium.	chain fatty acids	29-46	interleukin 1 beta	Homo sapiens	141-149
27072015-6	2016	Shikonin prevented IL-1beta- or tumor necrosis factor (TNF)-alpha-mediated IL-6, IL-8, and CCL20 production in HPDLC.	shikonin	0-8	interleukin 1 beta	Homo sapiens	19-27
27102898-6	2016	It also inhibited the IL-1beta-induced expression of inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the production of NO and prostaglandin E2 (PGE2) in human OA chondrocytes.	Nitric Oxide	63-75	interleukin 1 beta	Homo sapiens	22-30
27102898-6	2016	It also inhibited the IL-1beta-induced expression of inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the production of NO and prostaglandin E2 (PGE2) in human OA chondrocytes.	Dinoprostone	163-179	interleukin 1 beta	Homo sapiens	22-30
27102898-6	2016	It also inhibited the IL-1beta-induced expression of inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the production of NO and prostaglandin E2 (PGE2) in human OA chondrocytes.	Dinoprostone	181-185	interleukin 1 beta	Homo sapiens	22-30
26214284-0	2016	alpha-tocopherol decreases interleukin-1beta and -6 and increases human beta-defensin-1 and -2 secretion in human gingival fibroblasts stimulated with Porphyromonas gingivalis lipopolysaccharide.	alpha-Tocopherol	0-16	interleukin 1 beta	Homo sapiens	27-51
27035829-11	2016	RESULTS: In vitro studies showed that 1,25(OH)2D3 significantly reduced IL-1beta- or TNF-alpha-induced inflammatory responses, such as IL-8 expression and prostaglandin activity.	Calcitriol	38-49	interleukin 1 beta	Homo sapiens	72-81
27145239-10	2016	LCFA (oleic acid) up-regulated tumor necrosis fator-alpha, monocyte chemoattractant-1 and interleukin-1beta while down-regulated IL-6 and IL-8 secretion to a higher extent than MCFA in mRNA and protein levels.	lcfa	0-4	interleukin 1 beta	Homo sapiens	90-107
27145239-10	2016	LCFA (oleic acid) up-regulated tumor necrosis fator-alpha, monocyte chemoattractant-1 and interleukin-1beta while down-regulated IL-6 and IL-8 secretion to a higher extent than MCFA in mRNA and protein levels.	Oleic Acid	6-16	interleukin 1 beta	Homo sapiens	90-107
27009163-4	2016	IL-1beta elicited an amiloride-sensitive increase in Na(+) transport in taste buds.	Amiloride	21-30	interleukin 1 beta	Homo sapiens	0-8
27009163-6	2016	The speed and partial amiloride sensitivity of these changes in Na(+) flux indicate that IL-1beta and TNF-alpha modulate epithelial Na(+) channel (ENaC) function.	Amiloride	22-31	interleukin 1 beta	Homo sapiens	89-97
27082436-4	2016	To evaluate the prophylactic function of DHA in OA, the effect of DHA on cartilage degeneration was assessed in interleukin-1beta (IL-1beta) stimulated human chondrosarcoma SW1353 cells or a rat model of adjuvant-induced arthritis (AIA).	Docosahexaenoic Acids	66-69	interleukin 1 beta	Homo sapiens	112-129
27082436-4	2016	To evaluate the prophylactic function of DHA in OA, the effect of DHA on cartilage degeneration was assessed in interleukin-1beta (IL-1beta) stimulated human chondrosarcoma SW1353 cells or a rat model of adjuvant-induced arthritis (AIA).	Docosahexaenoic Acids	66-69	interleukin 1 beta	Homo sapiens	131-139
27082436-9	2016	The DHA-mediated inhibition of MMP-13 expression was partially attributed to the inactivation of the p38 mitogen-activated protein kinases pathway by suppressing p-p38 in IL-1beta-stimulated SW1353 cells and a rat AIA model.	Docosahexaenoic Acids	4-7	interleukin 1 beta	Homo sapiens	171-179
26899309-3	2016	We first observed that tangeretin inhibited LPS-induced production of nitric oxide, tumor necrosis factor alpha, interleukin (IL)-6, and IL-1beta, as well as LPS-induced mRNA expression of inducible nitric oxide synthases and cytokines.	tangeretin	23-33	interleukin 1 beta	Homo sapiens	137-145
27142735-6	2016	C16:0-, Pam3CSK4-, or LPS-induced IL-1beta production was inhibited by 4-phenylbutyric acid, an inhibitor of ER stress suggesting that IL-1beta production induced by these agonists is partly mediated through ER stress.	4-phenylbutyric acid	71-91	interleukin 1 beta	Homo sapiens	34-42
27142735-6	2016	C16:0-, Pam3CSK4-, or LPS-induced IL-1beta production was inhibited by 4-phenylbutyric acid, an inhibitor of ER stress suggesting that IL-1beta production induced by these agonists is partly mediated through ER stress.	4-phenylbutyric acid	71-91	interleukin 1 beta	Homo sapiens	135-143
27142735-7	2016	Among two ER stress-inducing molecules, thapsigargin but not tunicamycin led to the expression of pro-IL-1beta and secretion of IL-1beta.	Thapsigargin	40-52	interleukin 1 beta	Homo sapiens	98-110
27142735-7	2016	Among two ER stress-inducing molecules, thapsigargin but not tunicamycin led to the expression of pro-IL-1beta and secretion of IL-1beta.	Thapsigargin	40-52	interleukin 1 beta	Homo sapiens	102-110
27142735-9	2016	Although both C16:0 and thapsigargin-induced IL-1beta secretion was inhibited by DHA, only C16:0-mediated ER stress was responsive to DHA.	Thapsigargin	24-36	interleukin 1 beta	Homo sapiens	45-53
26364593-6	2016	IL-1beta had a positive correlation with nicotine (r = 0.351) and the cotinine (r = 0.376), nicotine (r = 0.492) and hydroxycotinine (r = 0.358), and hydroxycotinine (r = 0.413) levels at 2 wk and 4 and 6 mo follow-up, respectively.	Nicotine	41-49	interleukin 1 beta	Homo sapiens	0-8
27142735-9	2016	Although both C16:0 and thapsigargin-induced IL-1beta secretion was inhibited by DHA, only C16:0-mediated ER stress was responsive to DHA.	Docosahexaenoic Acids	81-84	interleukin 1 beta	Homo sapiens	45-53
26364593-6	2016	IL-1beta had a positive correlation with nicotine (r = 0.351) and the cotinine (r = 0.376), nicotine (r = 0.492) and hydroxycotinine (r = 0.358), and hydroxycotinine (r = 0.413) levels at 2 wk and 4 and 6 mo follow-up, respectively.	Cotinine	70-78	interleukin 1 beta	Homo sapiens	0-8
26944408-0	2016	Aloin Inhibits Interleukin (IL)-1beta-Stimulated IL-8 Production in KB Cells.	alloin	0-5	interleukin 1 beta	Homo sapiens	15-37
26364593-6	2016	IL-1beta had a positive correlation with nicotine (r = 0.351) and the cotinine (r = 0.376), nicotine (r = 0.492) and hydroxycotinine (r = 0.358), and hydroxycotinine (r = 0.413) levels at 2 wk and 4 and 6 mo follow-up, respectively.	Nicotine	92-100	interleukin 1 beta	Homo sapiens	0-8
26944408-15	2016	CONCLUSIONS: Results indicated that IL-1beta in saliva stimulates epithelial cells to produce IL-8 and that aloin effectively inhibits salivary IL-1beta-induced IL-8 production by mitigating the p38 and ERK pathway.	alloin	108-113	interleukin 1 beta	Homo sapiens	144-152
26944408-2	2016	This study investigates stimulatory effects of salivary IL-1beta in IL-8 production and determines if aloin inhibits IL-1beta-stimulated IL-8 production in epithelial cells.	alloin	102-107	interleukin 1 beta	Homo sapiens	117-125
26364593-6	2016	IL-1beta had a positive correlation with nicotine (r = 0.351) and the cotinine (r = 0.376), nicotine (r = 0.492) and hydroxycotinine (r = 0.358), and hydroxycotinine (r = 0.413) levels at 2 wk and 4 and 6 mo follow-up, respectively.	hydroxycotinine	117-132	interleukin 1 beta	Homo sapiens	0-8
26944408-8	2016	KB cells were pretreated with aloin, and its effect on IL-1beta-induced IL-8 production was examined by ELISA and Western blot analysis.	alloin	30-35	interleukin 1 beta	Homo sapiens	55-63
26944408-13	2016	Aloin pretreatment inhibited IL-1beta-induced IL-8 production in a dose-dependent manner and inhibited activation of the p38 and ERK signaling pathway.	alloin	0-5	interleukin 1 beta	Homo sapiens	29-37
26364593-6	2016	IL-1beta had a positive correlation with nicotine (r = 0.351) and the cotinine (r = 0.376), nicotine (r = 0.492) and hydroxycotinine (r = 0.358), and hydroxycotinine (r = 0.413) levels at 2 wk and 4 and 6 mo follow-up, respectively.	hydroxycotinine	150-165	interleukin 1 beta	Homo sapiens	0-8
26364593-7	2016	CONCLUSIONS: This 1-year prospective smoking cessation study without nonsurgical periodontal therapy shows IL-1beta in gingival crevicular fluid could have a positive relationship with the nicotine and cotinine levels in saliva.	Nicotine	189-197	interleukin 1 beta	Homo sapiens	107-115
26364593-7	2016	CONCLUSIONS: This 1-year prospective smoking cessation study without nonsurgical periodontal therapy shows IL-1beta in gingival crevicular fluid could have a positive relationship with the nicotine and cotinine levels in saliva.	Cotinine	202-210	interleukin 1 beta	Homo sapiens	107-115
27048661-9	2016	In fact, treatment of CS-exposed animals with RLX reduced the inflammatory recruitment of leukocytes, accompanied by a significant reduction of the release of proinflammatory cytokines (tumor necrosis factor alpha and interleukin-1beta).	Cesium	22-24	interleukin 1 beta	Homo sapiens	218-235
27286958-8	2016	LLDT-8 inhibited NO release and expression of TNF-alpha, IL-1beta and iNOS in BV-2 microglia and primary microglia treated with LPS.	5alpha-Hydroxytriptolide	0-6	interleukin 1 beta	Homo sapiens	57-65
27048661-9	2016	In fact, treatment of CS-exposed animals with RLX reduced the inflammatory recruitment of leukocytes, accompanied by a significant reduction of the release of proinflammatory cytokines (tumor necrosis factor alpha and interleukin-1beta).	Relaxin	46-49	interleukin 1 beta	Homo sapiens	218-235
27174187-11	2016	LPS+ATP treatment induced inflammasome complex assembly and activation, triggering the release of IL-1beta in both CMF and CF.	Adenosine Triphosphate	4-7	interleukin 1 beta	Homo sapiens	98-106
27121946-5	2016	It was demonstrated that beta-glucan induced the activation of nuclear factor (NF)-kappaB and markedly increased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) in macrophages.	beta-Glucans	25-36	interleukin 1 beta	Homo sapiens	171-189
27121946-5	2016	It was demonstrated that beta-glucan induced the activation of nuclear factor (NF)-kappaB and markedly increased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) in macrophages.	beta-Glucans	25-36	interleukin 1 beta	Homo sapiens	191-199
27105502-8	2016	The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	90-115	interleukin 1 beta	Homo sapiens	72-80
27121946-6	2016	Treatment with TET resulted in downregulation of phosphorylated NF-kappaB p65 and reduction of the production of TNF-alpha and IL-1beta.	tetrandrine	15-18	interleukin 1 beta	Homo sapiens	127-135
27035425-9	2016	We obtained 5 key genes (PIK3R2, CCNB1, IL2, IL1B and CDC6) for decitabine treatment that were validated by RT-PCR.	Decitabine	64-74	interleukin 1 beta	Homo sapiens	45-49
27035425-10	2016	In conclusion, we successfully identified 5 key genes (PIK3R2, CCNB1, IL2, IL1B and CDC6) and validated them, which provides insight into the molecular mechanisms of decitabine treatment and may be potential pathogenic biomarkers for the therapy of ovarian cancer.	Decitabine	166-176	interleukin 1 beta	Homo sapiens	75-79
26981789-9	2016	MTX was significantly induced IL-1beta and IL-6.17beta-estradiol, PPT and G-1 significantly decreased effects of MTX.	Methotrexate	0-3	interleukin 1 beta	Homo sapiens	30-38
26656048-0	2016	PGE1 Attenuates IL-1beta-induced NGF Expression in Human Intervertebral Disc Cells.	Alprostadil	0-4	interleukin 1 beta	Homo sapiens	16-24
27082728-7	2016	The results of the present study demonstrated that WIN-55 inhibited ADAMTS-4 activity in unstimulated and IL-1beta-stimulated primary human OA articular chondrocytes in a concentration-dependent manner.	win-55	51-57	interleukin 1 beta	Homo sapiens	106-114
27082728-12	2016	In conclusion, to the best of our knowledge, the present study provides the first in vitro evidence supporting that the synthetic cannabinoid WIN-55 inhibits ADAMTS-4 activity in unstimulated and IL-1beta-stimulated human OA articular chondrocytes by decreasing the mRNA stability/expression of syndecan-1 via CB2.	Cannabinoids	130-141	interleukin 1 beta	Homo sapiens	196-204
27082728-12	2016	In conclusion, to the best of our knowledge, the present study provides the first in vitro evidence supporting that the synthetic cannabinoid WIN-55 inhibits ADAMTS-4 activity in unstimulated and IL-1beta-stimulated human OA articular chondrocytes by decreasing the mRNA stability/expression of syndecan-1 via CB2.	win-55	142-148	interleukin 1 beta	Homo sapiens	196-204
27187448-0	2016	Resveratrol Interferes with IL1-beta-Induced Pro-Inflammatory Paracrine Interaction between Primary Chondrocytes and Macrophages.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	28-36
26601827-0	2016	The IL-1B Genetic Polymorphism Is Associated with Aspirin-Induced PepticUlcers in a Korean Ethnic Group.	Aspirin	50-57	interleukin 1 beta	Homo sapiens	4-9
26601827-8	2016	On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1beta -581C/ T, and the CT/TT genotypes of IL-1beta -1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04).	Aspirin	183-190	interleukin 1 beta	Homo sapiens	87-95
26601827-8	2016	On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1beta -581C/ T, and the CT/TT genotypes of IL-1beta -1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04).	Aspirin	183-190	interleukin 1 beta	Homo sapiens	133-141
26601827-9	2016	CONCLUSIONS: The IL-1beta -581C/T and IL-1beta -1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.	Aspirin	98-105	interleukin 1 beta	Homo sapiens	17-25
26601827-9	2016	CONCLUSIONS: The IL-1beta -581C/T and IL-1beta -1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.	Aspirin	98-105	interleukin 1 beta	Homo sapiens	38-46
27207962-9	2016	Cholesterol crystals and ATP induced IL-1beta release from lipopolysaccharide-primed human atherosclerotic lesion plaques.	Cholesterol	0-11	interleukin 1 beta	Homo sapiens	37-45
27207962-9	2016	Cholesterol crystals and ATP induced IL-1beta release from lipopolysaccharide-primed human atherosclerotic lesion plaques.	Adenosine Triphosphate	25-28	interleukin 1 beta	Homo sapiens	37-45
27189045-7	2016	Three of 4 markers discriminating between SP and SN RA (IL-1beta, IL-15 and Eotaxin, but not CCL5) were similarly modulated in independent cohorts.	TFF2 protein, human	42-44	interleukin 1 beta	Homo sapiens	56-64
27347349-8	2016	IL-1beta and TNF-alpha could activate AP1 transcriptional activity in hFOB1.19 cells (P &lt; 0.001), but the activation was inhibited when cells were pretreated with inhibitor of JNKs, SP600125 (P &lt; 0.001).	pyrazolanthrone	185-193	interleukin 1 beta	Homo sapiens	0-8
27190695-8	2016	However, exposure to TNF-alpha + IFN-gamma + IL1beta followed by a 5 h exposure to 2 mmol/L H2O2 resulted in a 500% increase in (14)C-PEG leak as well as leak to the luminal mitogen, epidermal growth factor.	Polyethylene Glycols	134-137	interleukin 1 beta	Homo sapiens	45-52
27058421-3	2016	Here we report that hypoxia (1% O2) treatment of PrECs, prostate cell lines, and a macrophage cell line (THP-1) increased the levels of NLRP3, AIM2, and pro-IL-1beta.	Oxygen	32-34	interleukin 1 beta	Homo sapiens	153-165
26701127-5	2016	In the colon of mice with dextran sulphate sodium-induced colitis and in patients with CD, only IL-36alpha, gamma and IL-38 were induced at relatively low levels and correlated with IL-1beta and IL-17A.	dextran sulphate sodium	26-49	interleukin 1 beta	Homo sapiens	182-190
26891959-8	2016	Comparing Alu-transfected HUVEC with high-glucose treated HUVEC, we found that Alu RNA elicited the production of reactive oxygen species (ROS) and up-regulated interleukin-1beta (IL-1beta) expression and secretion in a similar manner as high-glucose treatment.	Glucose	243-250	interleukin 1 beta	Homo sapiens	161-178
26891959-8	2016	Comparing Alu-transfected HUVEC with high-glucose treated HUVEC, we found that Alu RNA elicited the production of reactive oxygen species (ROS) and up-regulated interleukin-1beta (IL-1beta) expression and secretion in a similar manner as high-glucose treatment.	Glucose	243-250	interleukin 1 beta	Homo sapiens	180-188
26940199-6	2016	After 3 hrs, macrophages treated with DEX alone or with CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX showed a significant reduction (p&lt;0.05) for all cytokines gene expression, that was still significant for IL-1beta after 24 hrs (p&lt;0.05).	Dexamethasone	38-41	interleukin 1 beta	Homo sapiens	198-206
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	117-119	interleukin 1 beta	Homo sapiens	238-246
26940199-6	2016	After 3 hrs, macrophages treated with DEX alone or with CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX showed a significant reduction (p&lt;0.05) for all cytokines gene expression, that was still significant for IL-1beta after 24 hrs (p&lt;0.05).	dex-mtx	81-88	interleukin 1 beta	Homo sapiens	198-206
26940199-9	2016	Finally, ICC showed, after 24 hrs of CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX treatment a reduction (p&lt;0.05) of IL-1beta and IL-6 expression, versus CNT; DEX alone reduced only IL-1beta (p&lt;0.05).	Dexamethasone	46-49	interleukin 1 beta	Homo sapiens	107-115
26940199-9	2016	Finally, ICC showed, after 24 hrs of CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX treatment a reduction (p&lt;0.05) of IL-1beta and IL-6 expression, versus CNT; DEX alone reduced only IL-1beta (p&lt;0.05).	Dexamethasone	46-49	interleukin 1 beta	Homo sapiens	172-180
26940199-9	2016	Finally, ICC showed, after 24 hrs of CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX treatment a reduction (p&lt;0.05) of IL-1beta and IL-6 expression, versus CNT; DEX alone reduced only IL-1beta (p&lt;0.05).	dex-mtx	62-69	interleukin 1 beta	Homo sapiens	107-115
26940199-9	2016	Finally, ICC showed, after 24 hrs of CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX treatment a reduction (p&lt;0.05) of IL-1beta and IL-6 expression, versus CNT; DEX alone reduced only IL-1beta (p&lt;0.05).	dex-mtx	62-69	interleukin 1 beta	Homo sapiens	172-180
26940199-9	2016	Finally, ICC showed, after 24 hrs of CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX treatment a reduction (p&lt;0.05) of IL-1beta and IL-6 expression, versus CNT; DEX alone reduced only IL-1beta (p&lt;0.05).	Dexamethasone	62-65	interleukin 1 beta	Homo sapiens	107-115
26940199-9	2016	Finally, ICC showed, after 24 hrs of CTLA4-Ig-DEX or CTLA4-Ig-DEX-MTX treatment a reduction (p&lt;0.05) of IL-1beta and IL-6 expression, versus CNT; DEX alone reduced only IL-1beta (p&lt;0.05).	Dexamethasone	62-65	interleukin 1 beta	Homo sapiens	172-180
27128803-4	2016	CS exposure alone reduced SALB potency and efficacy associated with decreased beta2-adrenoceptor mRNA expression, and increased tumour necrosis factor alpha (TNFalpha) and interleukin-1beta (IL-1beta) expression.	Cesium	0-2	interleukin 1 beta	Homo sapiens	191-199
26994310-11	2016	At these increased concentrations, Arthrokinex  induced IL-1-Ra joint injections produce an IL-1-Ra to IL-1beta ratio of 999:1.	arthrokinex	35-46	interleukin 1 beta	Homo sapiens	103-111
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	165-167	interleukin 1 beta	Homo sapiens	238-246
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Eugenol	177-184	interleukin 1 beta	Homo sapiens	238-246
27488002-0	2016	Interleukin-1beta (IL-1beta) &amp; IL-4 gene polymorphisms in patients with systemic lupus erythematosus (SLE) &amp; their association with susceptibility to SLE.	Adenosine Monophosphate	112-115	interleukin 1 beta	Homo sapiens	0-17
27107084-9	2016	Hangeshashinto potently inhibited PGE2 production by interleukin (IL)-1beta-stimulated HPLFs and HGFs.	Dinoprostone	34-38	interleukin 1 beta	Homo sapiens	53-75
27488002-0	2016	Interleukin-1beta (IL-1beta) &amp; IL-4 gene polymorphisms in patients with systemic lupus erythematosus (SLE) &amp; their association with susceptibility to SLE.	Adenosine Monophosphate	112-115	interleukin 1 beta	Homo sapiens	19-27
27488002-9	2016	INTERPRETATION &amp; CONCLUSIONS: The present findings suggest that IL-1beta T-31C and IL-4 VNTR polymorphisms but not IL-1beta C-511T polymorphism may contribute in SLE pathogenesis.	Adenosine Monophosphate	16-19	interleukin 1 beta	Homo sapiens	68-76
27054346-5	2016	Second, linking these findings to differences in circulating cytokine levels, we show in a separate sample that those with a history of rMDD had higher peripheral levels of IL-33 and IL-1beta compared with women with a single MDD episode or no history of MDD.	rmdd	136-140	interleukin 1 beta	Homo sapiens	183-191
26155993-9	2016	The expression of ICAM-1 was also significantly reduced following exposure of endothelial cells to trophoblastic debris with the nitric oxide donor or following treatment of endothelial cells with interleukin (IL)-1beta in the presence of calcium.	Calcium	239-246	interleukin 1 beta	Homo sapiens	197-219
26998763-5	2016	IL-1R was detected on T(H)17 cells but not on type 1 helper T (T(H)1) cells, and ATP-treated T(H)17 cells showed enhanced survival compared with ATP-treated T(H)1 cells, suggesting autocrine action of T(H)17-derived IL-1beta.	Adenosine Triphosphate	81-84	interleukin 1 beta	Homo sapiens	216-224
26574023-6	2016	Cellular IL-1beta release depended on potassium efflux and the activity of proteins nucleotide-binding oligomerization domain-like receptor protein 3 and caspase-1.	Potassium	38-47	interleukin 1 beta	Homo sapiens	9-17
27297965-0	2016	Tetrabromobisphenol A and hexabromocyclododecane alter secretion of IL-1beta from human immune cells.	tetrabromobisphenol A	0-21	interleukin 1 beta	Homo sapiens	68-76
27297965-0	2016	Tetrabromobisphenol A and hexabromocyclododecane alter secretion of IL-1beta from human immune cells.	hexabromocyclododecane	26-48	interleukin 1 beta	Homo sapiens	68-76
27297965-4	2016	This study examines whether exposures to varying concentrations (0.05-5.0 muM) of TBBPA and HBCD for 24 h, 48 h and 6 days interfere with the ability of immune cells to secrete IL-1beta.	tetrabromobisphenol A	82-87	interleukin 1 beta	Homo sapiens	177-185
27297965-6	2016	Both increased and decreased secretion of IL-1beta from all three types of cell preparation were seen with TBBPA exposures and were dependent on concentration and length of exposure.	tetrabromobisphenol A	107-112	interleukin 1 beta	Homo sapiens	42-50
26108184-3	2016	Here we found that yonkenafil significantly suppressed the production of NO, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) and the protein expression of inducible NO synthase (iNOS) induced by LPS in microglial cells in a concentration-dependent manner.	yonkenafil	19-29	interleukin 1 beta	Homo sapiens	77-94
26108184-3	2016	Here we found that yonkenafil significantly suppressed the production of NO, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) and the protein expression of inducible NO synthase (iNOS) induced by LPS in microglial cells in a concentration-dependent manner.	yonkenafil	19-29	interleukin 1 beta	Homo sapiens	96-104
26745968-7	2016	More specifically, doxycycline treatment lowered the expression of the microglial activation marker IBA-1 as well as the production of ROS, NO, and proinflammatory cytokines (TNF-alpha and IL-1beta).	Doxycycline	19-30	interleukin 1 beta	Homo sapiens	189-197
26272212-11	2016	In contrast, CS exposure resulted in significant increases in IL-1beta, IL-6, TNF-alpha expression, and oxidative stress.	Cesium	13-15	interleukin 1 beta	Homo sapiens	62-70
27226903-5	2016	Significant involvement of pro-inflammatory cytokines-including interleukin (IL)-1beta, IL-6 and tumour necrosis factor-alpha-exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes.	Malondialdehyde	206-221	interleukin 1 beta	Homo sapiens	64-86
29235333-9	2016	Curcumin negated the activating effect of Abeta42 on pro-inflammatory cytokines, starting immediately for IL-1beta and on 3-6 hours for TNFalpha, which resulted in decreased extracellular concentrations of these cytokines.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	106-114
26970310-4	2016	Furthermore, a knockdown of MTA1 by siRNA in the human fibroblast-like synovial cell line MH7A was found to impair the 4-hydroxynonenal (4-HNE)-induced transcriptional expression levels of certain proinflammatory cytokines including IL-1beta, TNF-alpha and IL-6.	4-hydroxy-2-nonenal	119-135	interleukin 1 beta	Homo sapiens	233-241
27104574-3	2016	Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 beta	Homo sapiens	62-70
27092499-9	2016	Exposure of THP-1 macrophages to 50 microg/mL of anatase (50 nm) TiO2 particles increased interleukin (IL)-1beta expression level, and exposure of Caco-2 cells to 50 microg/mL of anatase (50 nm) TiO2 particles also increased IL-8 expression.	titanium dioxide	65-69	interleukin 1 beta	Homo sapiens	90-112
26858253-5	2016	Human TXNIP promoter analyses and chromatin immunoprecipitation studies revealed that the IL-1beta effect was mediated by inhibition of carbohydrate response element binding protein activity.	Carbohydrates	136-148	interleukin 1 beta	Homo sapiens	90-98
26902174-4	2016	Suppression of ER stress, using ER stress inhibitor tauroursodeoxycholic acid (TUDCA) or siRNA knockdown of IRE1alpha and GRP78, significantly downregulated LPS-, poly(I:C)- or IL-1beta-induced production of IL-6, IL-8, IL-1beta and MCP-1.	ursodoxicoltaurine	52-77	interleukin 1 beta	Homo sapiens	177-185
27078871-15	2016	The hints of associations deduced for subjects belonging to NIA in our case-control study for both IL1B -511 C&gt;T and IL1RN 86bp VNTR were duly validated vide significant p values seen for NIA in all three genetic models (OR range = 0.62-0.76, p range = 0.01-0.04 and OR range = 1.51-2.25, p range = 0.004-0.04 respectively).	Magestin	60-63	interleukin 1 beta	Homo sapiens	99-103
27044314-3	2016	The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Beta, MCP1, ALOX5, PTGS2, MGST1 and NOS2) related to inflammation in unstimulated cultured THP1 macrophages.	Docosahexaenoic Acids	57-60	interleukin 1 beta	Homo sapiens	140-147
27044314-3	2016	The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Beta, MCP1, ALOX5, PTGS2, MGST1 and NOS2) related to inflammation in unstimulated cultured THP1 macrophages.	Eicosapentaenoic Acid	75-78	interleukin 1 beta	Homo sapiens	140-147
27044314-3	2016	The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Beta, MCP1, ALOX5, PTGS2, MGST1 and NOS2) related to inflammation in unstimulated cultured THP1 macrophages.	Docosahexaenoic Acids	81-84	interleukin 1 beta	Homo sapiens	140-147
27044314-7	2016	Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1.	Eicosapentaenoic Acid	30-33	interleukin 1 beta	Homo sapiens	107-114
27044314-7	2016	Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1.	Docosahexaenoic Acids	42-45	interleukin 1 beta	Homo sapiens	107-114
27062120-5	2016	In keeping with this, alum did not trigger IL-1beta production from human PMN, and the lysosomotropic peptide Leu-Leu-OMe stimulated only weak NLRP3-dependent IL-1beta production from murine neutrophils, suggesting that lysosomal rupture is not a strong stimulus for NLRP3 activation in neutrophils.	leucyl-leucine-methyl ester	110-121	interleukin 1 beta	Homo sapiens	159-167
27012760-6	2016	We investigated this issue by monitoring the effects of diketopiperazine on phorbol-12-myristate 13-acetate (PMA)-, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta-induced EPCR shedding in human umbilical vein endothelial cells (HUVECs), and cecal ligation and puncture (CLP)-mediated EPCR shedding in mice and underlying mechanism.	Diketopiperazines	56-72	interleukin 1 beta	Homo sapiens	155-177
26846886-8	2016	The results showed that treatment of TEN significantly inhibited IL-1beta-induced NO and PGE2 production.	Dinoprostone	89-93	interleukin 1 beta	Homo sapiens	65-73
26499345-7	2016	The results showed that EA suppressed IL-1beta-induced collagenase-3 (MMP-13), NO, and PGE2 production in a dose-dependent manner.	Dinoprostone	87-91	interleukin 1 beta	Homo sapiens	38-46
27135904-7	2016	Oral lansoprazole therapy decreased the frequency of acute exacerbation of COPD by alleviating gastroesophageal reflux and lowering the levels of IL-1beta, IL-6, IL-8, TNF-alpha and GM-CSF in the sputum.	Lansoprazole	5-17	interleukin 1 beta	Homo sapiens	146-154
26179980-5	2016	The results showed that exposure of monocytes to non-toxic doses of U-PM alone caused generation of reactive oxygen species (ROS), increased phosphorylation of p38, and activation of monocytes which was reflected by up-regulation of MMP-2, MMP-9 and proinflammatory cytokines IL-1beta and IL-8 expression and increased activity of pro-MMP-2 and pro-MMP-9.	u-pm	68-72	interleukin 1 beta	Homo sapiens	276-284
26825457-8	2016	AZO blocked production of IL-1beta and activations of caspase-1 and nuclear factor-kappaB by inhibiting IkappaB kinase beta and receptor interacting protein 2.	anthrone	0-3	interleukin 1 beta	Homo sapiens	26-34
27186361-6	2016	Exendin-4 and glucose-dependent insulinotropic polypepide elicited cyclic adenosine monophosphate generation, and suppressed the lipopolysaccharide-induced gene expression of inflammatory molecules, such as interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha, in U937 human monocytes.	Glucose	14-21	interleukin 1 beta	Homo sapiens	207-224
27186361-6	2016	Exendin-4 and glucose-dependent insulinotropic polypepide elicited cyclic adenosine monophosphate generation, and suppressed the lipopolysaccharide-induced gene expression of inflammatory molecules, such as interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha, in U937 human monocytes.	polypepide	47-57	interleukin 1 beta	Homo sapiens	207-224
26843596-8	2016	IL-1beta accelerated Ca(2+) clearance in a manner blocked by an IL-1beta receptor antagonist or by an inhibitor of neutral sphingomyelinase, the enzyme that produces ceramide.	Ceramides	166-174	interleukin 1 beta	Homo sapiens	0-8
26922535-7	2016	RESULTS: Exenatide significantly increased the level of IL-10 and decreased both TNF-alpha and IL-1beta in LPS-treated monocytes/macrophages.	Exenatide	9-18	interleukin 1 beta	Homo sapiens	95-103
26504904-6	2016	Patients who had higher levels of IL-1beta and IL-8 were more responsive to topical sulfasalazine therapy.	Sulfasalazine	84-97	interleukin 1 beta	Homo sapiens	34-42
26504904-8	2016	Furthermore, high concentrations of IL-1beta and IL-8 in the saliva are useful indicators for the application of topical sulfasalazine in OLP patients refractory to steroid treatment.	Sulfasalazine	121-134	interleukin 1 beta	Homo sapiens	36-44
27471628-0	2016	AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 beta and IL-18.	Arsenic	27-34	interleukin 1 beta	Homo sapiens	56-65
27471628-7	2016	The data from current study show sub-chronic arsenic exposure activates AIM2 inflammasome which in turn activates caspase-1 and enhances the secretion of IL-1beta and IL-18 in HaCaT cells and the skin of BALB/c mice.	Arsenic	45-52	interleukin 1 beta	Homo sapiens	154-162
27471628-8	2016	In addition, arsenic-promoted activation of AIM2 inflammasome and increase of IL-1beta/IL-18 production are inhibited by PKR inhibitor in HaCaT cells or in the skin of PKR mutant mice, indicating a potential role of PKR in arsenic-induced sterile inflammation.	Arsenic	13-20	interleukin 1 beta	Homo sapiens	78-86
26971994-4	2016	We found that IRE1alpha mediates SFA-induced IL-1beta secretion by macrophages and that its activation by SFAs does not rely on unfolded protein sensing.	Fatty Acids	33-36	interleukin 1 beta	Homo sapiens	45-53
26971994-5	2016	We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels.	Phosphatidylcholines	162-181	interleukin 1 beta	Homo sapiens	85-93
26971994-5	2016	We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels.	Phosphatidylcholines	183-185	interleukin 1 beta	Homo sapiens	85-93
26971994-5	2016	We show instead that the ability of SFAs to stimulate either IRE1alpha activation or IL-1beta secretion can be specifically reduced by preventing their flux into phosphatidylcholine (PC) or by increasing unsaturated PC levels.	Phosphatidylcholines	216-218	interleukin 1 beta	Homo sapiens	85-93
26901245-0	2016	Tetrachlorobenzoquinone Stimulates NLRP3 Inflammasome-Mediated Post-Translational Activation and Secretion of IL-1beta in the HUVEC Endothelial Cell Line.	tetrachlorobenzoquinone	0-23	interleukin 1 beta	Homo sapiens	110-118
26901245-2	2016	Although TCBQ has been shown to stimulate interleukin-1 beta (IL-1beta) expression, it is unknown whether TCBQ regulates post-translational IL-1beta activation.	tetrachlorobenzoquinone	9-13	interleukin 1 beta	Homo sapiens	42-60
26901245-2	2016	Although TCBQ has been shown to stimulate interleukin-1 beta (IL-1beta) expression, it is unknown whether TCBQ regulates post-translational IL-1beta activation.	tetrachlorobenzoquinone	9-13	interleukin 1 beta	Homo sapiens	62-70
26901245-7	2016	These results suggest that the NLRP3/IL-1beta signaling pathway plays an important role in TCBQ-induced endothelial cell pro-inflammatory responses, which may point to potential therapeutic approaches against TCBQ-mediated toxicity.	tetrachlorobenzoquinone	91-95	interleukin 1 beta	Homo sapiens	37-45
26901245-7	2016	These results suggest that the NLRP3/IL-1beta signaling pathway plays an important role in TCBQ-induced endothelial cell pro-inflammatory responses, which may point to potential therapeutic approaches against TCBQ-mediated toxicity.	tetrachlorobenzoquinone	209-213	interleukin 1 beta	Homo sapiens	37-45
26872986-6	2016	Moreover, ambroxol significantly alleviated LPS-induced the influx of inflammatory cells and the extracellular signal-regulated kinase 1/2 (Erk 1/2) expression in lung tissues, and inhibited increases in the mRNA expression of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, CCL-2 (monocyte chemotactic protein-1), KC (keratinocyte cell protein) and interleukin (IL)-1beta in lung tissues.	Ambroxol	10-18	interleukin 1 beta	Homo sapiens	368-390
26872986-9	2016	In addition, we found that ambroxol dose-dependently inhibited LPS-induced increases in the mRNA expression of MUC5AC, TNF-alpha, and IL-1beta in human bronchial epithelial cell (NCI-H292) by inhibiting the Erk signaling pathway.	Ambroxol	27-35	interleukin 1 beta	Homo sapiens	134-142
26892147-11	2016	The expression levels of azurocidin, telomerase reverse transcriptase, ferritin, and interleukin-1beta were also altered by co-treatment with ATO.	Arsenic Trioxide	142-145	interleukin 1 beta	Homo sapiens	85-102
26926996-2	2016	Here, we report that in monocytes and macrophages of patients with atherosclerotic coronary artery disease (CAD), overutilization of glucose promotes excessive and prolonged production of the cytokines IL-6 and IL-1beta, driving systemic and tissue inflammation.	Glucose	133-140	interleukin 1 beta	Homo sapiens	211-219
26940200-4	2016	In this study, we demonstrate that mTOR inhibitors-rapamycin (RAP), temisirolimus (TEM), torin-1 (TOR) and PP242 suppress invasion and migration induced by Tumor Necrosis Factor-alpha (TNFalpha) and tumor promoter, Phorbol 12-myristate 13-acetate (PMA) and also reduce the expression of the TNFalpha and IL1beta suggesting their potential to regulate factors in microenvironment that support tumor progression.	PP242	107-112	interleukin 1 beta	Homo sapiens	304-311
26934732-0	2016	Hyaluronic Acid Suppresses the Expression of Metalloproteinases in Osteoarthritic Cartilage Stimulated Simultaneously by Interleukin 1beta and Mechanical Load.	Hyaluronic Acid	0-15	interleukin 1 beta	Homo sapiens	121-138
25589513-3	2016	Saturated long-chain free fatty acids (FFAs) can provide such a signal and stimulate transcription of pro-IL-1beta.	saturated long-chain free fatty acids	0-37	interleukin 1 beta	Homo sapiens	102-114
25589513-10	2016	RESULTS: Butyrate decreased C16.0+MSU-induced production of IL-1beta, IL-6, IL-8 and IL-1beta mRNA in PBMCs from healthy donors.	Butyrates	9-17	interleukin 1 beta	Homo sapiens	60-68
25589513-10	2016	RESULTS: Butyrate decreased C16.0+MSU-induced production of IL-1beta, IL-6, IL-8 and IL-1beta mRNA in PBMCs from healthy donors.	Butyrates	9-17	interleukin 1 beta	Homo sapiens	85-93
25589513-13	2016	The HDAC inhibitor, panobinostat and the potent HDAC inhibitor, ITF-B, also decreased ex vivo C16.0+MSU-induced IL-1beta production.	Panobinostat	20-32	interleukin 1 beta	Homo sapiens	112-120
26898443-3	2016	The present study was aimed to investigate the effects of ligustrazine, a natural alkaloid compound, on the NLRP3 inflammasome pathway activation and interleukin-1beta (IL-1beta) generation in hepatocytes.	tetramethylpyrazine	58-70	interleukin 1 beta	Homo sapiens	150-167
26898443-3	2016	The present study was aimed to investigate the effects of ligustrazine, a natural alkaloid compound, on the NLRP3 inflammasome pathway activation and interleukin-1beta (IL-1beta) generation in hepatocytes.	tetramethylpyrazine	58-70	interleukin 1 beta	Homo sapiens	169-177
26898443-6	2016	Ligustrazine was found to reduce NLRP3 and cleaved-caspase-1, prevented IL-1beta cleavage, and decreased IL-1beta secretion into extracellular environment.	tetramethylpyrazine	0-12	interleukin 1 beta	Homo sapiens	72-80
26898443-6	2016	Ligustrazine was found to reduce NLRP3 and cleaved-caspase-1, prevented IL-1beta cleavage, and decreased IL-1beta secretion into extracellular environment.	tetramethylpyrazine	0-12	interleukin 1 beta	Homo sapiens	105-113
26898443-9	2016	TAK-242 also reduced cleaved-IL-1beta, and this reducing effect was enhanced by ligustrazine.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	0-7	interleukin 1 beta	Homo sapiens	29-37
26898443-10	2016	Collectively, the current results revealed that ligustrazine interrupted LPS-activated NLRP3 inflammasome signaling and reduced generation of IL-1beta in hepatocytes, which was associated with inhibition of TLR4.	tetramethylpyrazine	48-60	interleukin 1 beta	Homo sapiens	142-150
26514426-6	2016	Cilostazol significantly inhibited IL-1alpha or IL-1beta-induced extracellular signal-regulated kinase (ERK) phosphorylation and ADAM17 expression.	Cilostazol	0-10	interleukin 1 beta	Homo sapiens	48-56
26370103-11	2016	Otherwise, IL-1beta level was higher in MetS patients than in non-MetS patients (p = 0.012), and this finding was confirmed (p = 0.048) by multivariate analysis with adjustments for age, ethnicity, prednisone use, current and cumulative prednisone doses, and duration of use.	Prednisone	198-208	interleukin 1 beta	Homo sapiens	11-19
26370103-11	2016	Otherwise, IL-1beta level was higher in MetS patients than in non-MetS patients (p = 0.012), and this finding was confirmed (p = 0.048) by multivariate analysis with adjustments for age, ethnicity, prednisone use, current and cumulative prednisone doses, and duration of use.	Prednisone	237-247	interleukin 1 beta	Homo sapiens	11-19
26743485-5	2016	Interestingly, RA-UIP BALF cell cultures treated with lipopolysaccharide/ATP showed a potent stimulation of IL-18 secretion but not IL-1beta, the latter being already elevated in the unstimulated cultures, while examination of the intracellular IL-1beta levels in RA-UIP BALF cells upon NLRP3 inflammasome stimulation showed a significant upregulation of IL-1beta suggesting the NLRP3 pathway could be further activated.Taken together, our results suggest distinct inflammasome activation profiles between autoimmune and idiopathic lung fibrosis.	Adenosine Triphosphate	73-76	interleukin 1 beta	Homo sapiens	245-253
26743485-5	2016	Interestingly, RA-UIP BALF cell cultures treated with lipopolysaccharide/ATP showed a potent stimulation of IL-18 secretion but not IL-1beta, the latter being already elevated in the unstimulated cultures, while examination of the intracellular IL-1beta levels in RA-UIP BALF cells upon NLRP3 inflammasome stimulation showed a significant upregulation of IL-1beta suggesting the NLRP3 pathway could be further activated.Taken together, our results suggest distinct inflammasome activation profiles between autoimmune and idiopathic lung fibrosis.	Adenosine Triphosphate	73-76	interleukin 1 beta	Homo sapiens	245-253
26912818-4	2016	Treatment of three oral mesenchymal cells with interleukin (IL)-1beta or lipopoly-saccharide (LPS) reproducibly increased the production of glutamic acid and glutamine, but not that of glycine and proline.	Glutamic Acid	140-153	interleukin 1 beta	Homo sapiens	47-69
26912818-4	2016	Treatment of three oral mesenchymal cells with interleukin (IL)-1beta or lipopoly-saccharide (LPS) reproducibly increased the production of glutamic acid and glutamine, but not that of glycine and proline.	Glutamine	158-167	interleukin 1 beta	Homo sapiens	47-69
26930651-7	2016	In ex vivo studies, 100 muM of metformin decreased the TLR4 level by 19.9% (II group) or by 35% (III group) as well as IL-1beta and TNFalpha production.	Metformin	31-40	interleukin 1 beta	Homo sapiens	119-127
26928328-3	2016	Here, we show that VTX-2337 stimulates the release of mature IL-1beta and IL-18 from monocytic cells through coordinated actions on both TLR8 and the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome complex.	VTX-2337	19-27	interleukin 1 beta	Homo sapiens	61-69
26913600-5	2016	Given that an injury induced by BaCl2 is repaired with greater efficiency than controls in the absence of C/EBPbeta, we investigated the inflammatory response following BaCl2 and CTX injury and found that the levels of interleukin-1beta (IL-1beta), a proinflammatory cytokine, were robustly elevated following CTX injury and could induce C/EBPbeta expression in myoblasts.	barium chloride	32-37	interleukin 1 beta	Homo sapiens	219-236
26913600-5	2016	Given that an injury induced by BaCl2 is repaired with greater efficiency than controls in the absence of C/EBPbeta, we investigated the inflammatory response following BaCl2 and CTX injury and found that the levels of interleukin-1beta (IL-1beta), a proinflammatory cytokine, were robustly elevated following CTX injury and could induce C/EBPbeta expression in myoblasts.	barium chloride	32-37	interleukin 1 beta	Homo sapiens	238-246
26913035-5	2016	Furthermore, SiO2 exposure decreased uptake of fluorescently labeled Pam2CSK4 and Pam3CSK4, resulting in reduced secretion of IL-1beta, but not IL-6.	Silicon Dioxide	13-17	interleukin 1 beta	Homo sapiens	126-134
26877061-0	2016	Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1beta secretion in response to ATP.	Adenosine Triphosphate	97-100	interleukin 1 beta	Homo sapiens	63-71
26877061-6	2016	Given the ubiquitous presence of neutrophils and extracellular ATP in multiple inflammatory conditions, ATP-induced P2X7R activation and IL-1beta secretion by neutrophils likely has a significant, wide ranging clinical impact.	Adenosine Triphosphate	104-107	interleukin 1 beta	Homo sapiens	137-145
26877238-6	2016	Induction of HO-1 by cobalt protoporphyrin IX attenuated the inhibition of sulfate glycosaminoglycan and collagen type II (COL-II) synthesis and ameliorated the reduced expressions of aggrecan, COL-II, SOX-6 and SOX-9 mediated by IL-1beta.	cobaltiprotoporphyrin	21-45	interleukin 1 beta	Homo sapiens	230-238
26869854-10	2016	Noteworthy, the impaired TCA cycle in HT-1080 cells were associated with high mTORC1 activity, negligible protein level and activity of mTORC2, high expression of interleukin-1beta, interleukin-6 and heme oxygenase-1 which may contribute to the compensatory mechanism of TCA deficiency.	Trichloroacetic Acid	25-28	interleukin 1 beta	Homo sapiens	163-180
26866373-8	2016	ZnPP also blocked the ability of EGCG to increase the activity of an antioxidant (superoxide dismutase), and decrease markers of oxidative stress (myeloperoxidase and malondialdehyde) and inflammation (myeloperoxidase and IL-1beta), indicating that HO-1 is the upstream molecule that regulates the EGCG-mediated protection.	zinc protoporphyrin	0-4	interleukin 1 beta	Homo sapiens	222-230
26866373-8	2016	ZnPP also blocked the ability of EGCG to increase the activity of an antioxidant (superoxide dismutase), and decrease markers of oxidative stress (myeloperoxidase and malondialdehyde) and inflammation (myeloperoxidase and IL-1beta), indicating that HO-1 is the upstream molecule that regulates the EGCG-mediated protection.	epigallocatechin gallate	33-37	interleukin 1 beta	Homo sapiens	222-230
26909953-8	2016	The IL-1beta rs1143634 T allele was also positively connected to periodontitis, with TC + TT genotype carriers being significantly more at risk.	tc + tt	85-92	interleukin 1 beta	Homo sapiens	4-12
26566283-6	2016	RESULTS: IL-1beta increased the amplitude of current evoked by GABA in combination with clinically relevant concentrations of either etomidate (3 muM) or isoflurane (250 muM) (n = 5 to 17, P &lt; 0.05).	gamma-Aminobutyric Acid	63-67	interleukin 1 beta	Homo sapiens	9-17
26566283-6	2016	RESULTS: IL-1beta increased the amplitude of current evoked by GABA in combination with clinically relevant concentrations of either etomidate (3 muM) or isoflurane (250 muM) (n = 5 to 17, P &lt; 0.05).	Isoflurane	154-164	interleukin 1 beta	Homo sapiens	9-17
26566283-7	2016	Concentration-response plots for etomidate and isoflurane showed that IL-1beta increased the maximal current 3.3-fold (n = 5 to 9) and 1.5-fold (n = 8 to 11), respectively (P &lt; 0.05 for both), whereas the half-maximal effective concentrations were unchanged.	Etomidate	33-42	interleukin 1 beta	Homo sapiens	70-78
26566283-7	2016	Concentration-response plots for etomidate and isoflurane showed that IL-1beta increased the maximal current 3.3-fold (n = 5 to 9) and 1.5-fold (n = 8 to 11), respectively (P &lt; 0.05 for both), whereas the half-maximal effective concentrations were unchanged.	Isoflurane	47-57	interleukin 1 beta	Homo sapiens	70-78
26674566-6	2016	The proinflammatory cytokine IL1B, the bacterial product fsl-1, and viral analog polyinosinic:polycytidylic acid (poly [I:C]) significantly increased IRF1 mRNA expression and transcriptional activity in human primary myometrial cells.	Poly C	94-112	interleukin 1 beta	Homo sapiens	29-33
26825654-3	2016	Exposure of HPMCs to high glucose-based PD solutions resulted in ROS production, which can trigger NLRP3 activation, leading to IL-1beta secretion.	hpmcs	12-17	interleukin 1 beta	Homo sapiens	128-136
26825654-3	2016	Exposure of HPMCs to high glucose-based PD solutions resulted in ROS production, which can trigger NLRP3 activation, leading to IL-1beta secretion.	Glucose	26-33	interleukin 1 beta	Homo sapiens	128-136
26825654-3	2016	Exposure of HPMCs to high glucose-based PD solutions resulted in ROS production, which can trigger NLRP3 activation, leading to IL-1beta secretion.	Reactive Oxygen Species	65-68	interleukin 1 beta	Homo sapiens	128-136
26683671-6	2016	The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus.	Hydrogen	48-50	interleukin 1 beta	Homo sapiens	262-279
26831735-0	2016	Secretion of IL-1beta from imatinib-resistant chronic myeloid leukemia cells contributes to BCR-ABL mutation-independent imatinib resistance.	Imatinib Mesylate	27-35	interleukin 1 beta	Homo sapiens	13-21
26831735-0	2016	Secretion of IL-1beta from imatinib-resistant chronic myeloid leukemia cells contributes to BCR-ABL mutation-independent imatinib resistance.	Imatinib Mesylate	121-129	interleukin 1 beta	Homo sapiens	13-21
26831735-3	2016	Interleukin-1beta (IL-1beta) was more highly expressed in K562R than in the parental cell line K562S, and higher levels of IL-1beta contributed to the imatinib resistance of K562R.	Imatinib Mesylate	151-159	interleukin 1 beta	Homo sapiens	0-17
26831735-3	2016	Interleukin-1beta (IL-1beta) was more highly expressed in K562R than in the parental cell line K562S, and higher levels of IL-1beta contributed to the imatinib resistance of K562R.	Imatinib Mesylate	151-159	interleukin 1 beta	Homo sapiens	123-131
26319019-3	2016	In the present study, the anti-inflammatory effects of PQQ were investigated in interleukin (IL)-1beta-treated SW982 cells, a RA-like fibroblast-like synoviocytes (FLSs) injury model.	PQQ Cofactor	55-58	interleukin 1 beta	Homo sapiens	80-102
26319019-4	2016	Our observations showed that pretreatment with PQQ significantly inhibited the expression of matrix metalloproteinase (MMP)-1 and MMP-3 and suppressed the production of proinflammatory mediators such as TNF-alpha and IL-6 in IL-1beta-treated SW982 cells.	PQQ Cofactor	47-50	interleukin 1 beta	Homo sapiens	225-233
26319019-5	2016	The nuclear translocation of nuclear factor kappa B (NF-kappaB) and the phosphorylation level of p65, p38, and JNK MAP kinase pathways were also inhibited by PQQ in IL-1beta-stimulated SW982 cells.	PQQ Cofactor	158-161	interleukin 1 beta	Homo sapiens	165-173
26358366-9	2016	Pre-treatment with Dex inhibits dsRNA mimic poly IC induction of the inflammatory chemokine IP10 (CXCL10) and cytokine IL1B mRNA expression in THP-1 monocytes.	Dexamethasone	19-22	interleukin 1 beta	Homo sapiens	119-123
26410851-5	2016	Our results demonstrated that piperine attenuated LPS-induced MPO activity, lung edema, and inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production.	piperine	30-38	interleukin 1 beta	Homo sapiens	136-144
26410851-5	2016	Our results demonstrated that piperine attenuated LPS-induced MPO activity, lung edema, and inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production.	lps	50-53	interleukin 1 beta	Homo sapiens	136-144
26454413-11	2016	Adding rIL-37 suppressed TNF-alpha, IL-1beta and IL-6 production in IS cells.	ril-37	7-13	interleukin 1 beta	Homo sapiens	36-44
26454448-0	2016	Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1beta Production Through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells.	rebamipide	0-10	interleukin 1 beta	Homo sapiens	55-72
26454448-0	2016	Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1beta Production Through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells.	Uric Acid	22-38	interleukin 1 beta	Homo sapiens	55-72
26454448-1	2016	This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production.	rebamipide	38-48	interleukin 1 beta	Homo sapiens	179-196
26566633-10	2016	Vitamin D was significantly lower in ASCA positives (P = 0.044).Vitamin D showed positive correlation with IL-1beta (r 0.338, P &lt; 0.009) and negative correlation with VEGF (r -0.366, P &lt; 0.004).	Vitamin D	64-73	interleukin 1 beta	Homo sapiens	107-115
26616294-0	2016	Atrial natriuretic peptide down-regulates LPS/ATP-mediated IL-1beta release by inhibiting NF-kB, NLRP3 inflammasome and caspase-1 activation in THP-1 cells.	Adenosine Triphosphate	46-49	interleukin 1 beta	Homo sapiens	59-67
26616294-9	2016	The aim of our study was to evaluate the effect of ANP on IL-1beta/NALP3/caspase-1 expression in LPS/ATP-stimulated human THP1 monocytes.	Adenosine Triphosphate	101-104	interleukin 1 beta	Homo sapiens	58-66
26616294-10	2016	We provided new evidence of the direct involvement of ANP/NPR-1/cGMP axis on NF-kB/NALP3/caspase-1-mediated IL-1beta release and NF-kB-mediated pro-IL-1beta production.	Cyclic GMP	64-68	interleukin 1 beta	Homo sapiens	108-116
26608891-5	2016	Our results showed that acute administration of H-BCAA increased IL-1beta (~ 78%; p &lt;= 0.009) and TNF-alpha (~ 155%; p &lt;= 0.026) levels in the cerebral cortex but not in the hippocampus of infant rats.	h-bcaa	48-54	interleukin 1 beta	Homo sapiens	65-73
26624249-10	2016	The increase in ROS formation correlated with an increase in expression of Nrf2-mediated antioxidant genes as well as the expression and production of proinflammatory cytokine TNF-alpha, and interleukin 1 beta (IL-1beta) (p &lt; 0.05).	Reactive Oxygen Species	16-19	interleukin 1 beta	Homo sapiens	191-209
26624249-10	2016	The increase in ROS formation correlated with an increase in expression of Nrf2-mediated antioxidant genes as well as the expression and production of proinflammatory cytokine TNF-alpha, and interleukin 1 beta (IL-1beta) (p &lt; 0.05).	Reactive Oxygen Species	16-19	interleukin 1 beta	Homo sapiens	211-219
26707272-8	2016	MF also attenuated the IL-1beta-induced production of NO and PGE2, and reduced iNOS and COX-2 expression.	Dinoprostone	61-65	interleukin 1 beta	Homo sapiens	23-31
26526931-0	2016	Function of sustained released resveratrol on IL-1beta-induced hBMSC MMP13 secretion inhibition and chondrogenic differentiation promotion.	Resveratrol	31-42	interleukin 1 beta	Homo sapiens	46-54
26526931-4	2016	In this study, resveratrol release microspheres were developed, and the direct function of the released resveratrol on the interleukin-1beta was discussed.	Resveratrol	15-26	interleukin 1 beta	Homo sapiens	123-140
26526931-4	2016	In this study, resveratrol release microspheres were developed, and the direct function of the released resveratrol on the interleukin-1beta was discussed.	Resveratrol	104-115	interleukin 1 beta	Homo sapiens	123-140
26526931-12	2016	The released resveratrol directly inhibited the function of interleukin-1beta and thus downregulated metalloproteinase-13 mRNA expression.	Resveratrol	13-24	interleukin 1 beta	Homo sapiens	60-77
26526931-15	2016	The sustained released resveratrol inhibited interleukin-1beta-inducted metalloproteinase-13 activation and promoted chondrocyte differentiation.	Resveratrol	23-34	interleukin 1 beta	Homo sapiens	45-62
26682942-6	2016	RESULTS: IL-1beta increased NOX-1 expression, NADPH oxidase activity and ROS production, and decreased NOX-4 expression and H2O2 production in VSMC.	Reactive Oxygen Species	73-76	interleukin 1 beta	Homo sapiens	9-17
26682942-6	2016	RESULTS: IL-1beta increased NOX-1 expression, NADPH oxidase activity and ROS production, and decreased NOX-4 expression and H2O2 production in VSMC.	Hydrogen Peroxide	124-128	interleukin 1 beta	Homo sapiens	9-17
26682942-6	2016	RESULTS: IL-1beta increased NOX-1 expression, NADPH oxidase activity and ROS production, and decreased NOX-4 expression and H2O2 production in VSMC.	vsmc	143-147	interleukin 1 beta	Homo sapiens	9-17
26682942-7	2016	AngII potentiated the IL-1beta-mediated induction of NOX-1 expression, NADPH oxidase activity, ROS production, and cell migration.	Reactive Oxygen Species	95-98	interleukin 1 beta	Homo sapiens	22-30
26827637-3	2016	The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta).	sulforaphane	24-36	interleukin 1 beta	Homo sapiens	251-268
26172530-8	2016	In about half of the 58 spots, the IL-1beta-induced intensity changes were suppressed by simultaneous addition of SASP and/or MTX.	Methotrexate	126-129	interleukin 1 beta	Homo sapiens	35-43
26172530-10	2016	CONCLUSIONS AND CLINICAL RELEVANCE: The SASP and/or MTX treatments altered the protein profiles of exosomes and suppressed the effects of IL-1beta on the exosomal proteome.	Methotrexate	52-55	interleukin 1 beta	Homo sapiens	138-146
27141626-1	2016	OBJECTIVE: To observe the effect of acupoint injection of Lidocaine on serum IL-1beta, TNF-alpha and T-lymphocyte subset activities in patients undergoing laparoscopic cholecystectomy (LC), so as to reveal its mechanisms underlying relieving postoperative pain and potentiating rehabilitation.	Lidocaine	58-67	interleukin 1 beta	Homo sapiens	77-85
26814891-5	2016	Women using injectable DMPA had increased concentration of several soluble proteins of the innate and adaptive immune system, including IL-1alpha, IL-1beta, IL-2, MIP-1beta, IP-10, IL-8, TGF-beta, HBD4, IgA, IgG1, and IgG2.	N,N-dimethyl-4-anisidine	23-27	interleukin 1 beta	Homo sapiens	147-155
26546780-7	2016	The expression of interleukin-8 (IL-8) in HL-60 cells treated with conditioned media from HepaRG cells (HL-60/HepaRG) exhibited the highest ROC-AUC value of 0.758, followed by the expression of IL-1beta in HL-60/HepaRG (ROC-AUC: 0.726).	heparg	90-96	interleukin 1 beta	Homo sapiens	194-202
26789270-7	2016	Tbeta4 activation with a Tbeta4 peptide attenuated the H2O2-induced production of NO and PGE2 and up-regulated iNOS, COX-2, and osteoclastogenic cytokines (TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) as well as reversed the effect on RANKL and OPG in PDLCs.	Hydrogen Peroxide	55-59	interleukin 1 beta	Homo sapiens	167-175
26555265-5	2016	Furthermore, our data suggest that the ASC-NLRP3 inflammasome is responsible for QS-21-induced IL-1beta/IL-18 release.	saponin QA-21V1	81-86	interleukin 1 beta	Homo sapiens	95-103
26555265-7	2016	A nanoparticulate adjuvant that contains QS-21 as part of a heterogeneous mixture of saponins also induced IL-1beta in an NLRP3-dependent manner.	Saponins	85-93	interleukin 1 beta	Homo sapiens	107-115
26762166-10	2016	Nuomicron association was observed between IL-1beta, IL-6 and MMP-13 expression levels and cartilage defects or patients" age.	nuomicron	0-9	interleukin 1 beta	Homo sapiens	43-51
26607460-7	2016	The inhibition of NG-R1 on oxLDL-induced TNF-alpha and IL-1beta productions can be reversed by PPARgamma antagonist GW9662.	2-chloro-5-nitrobenzanilide	116-122	interleukin 1 beta	Homo sapiens	55-63
26518974-6	2016	IONP-PEG exposure significantly increased ROS, mitochondrial dysfunction and pro-inflammatory cytokines release (IL-1beta and TNF-alpha).	ionp-peg	0-8	interleukin 1 beta	Homo sapiens	113-121
26429117-9	2016	Indeed, sphingosine, which accumulates upon inhibition of SK1 activity, and sphingosine-like compounds promote activation of the inflammasome, which is linked with multiple sclerosis, to stimulate formation of the pro-inflammatory mediator, IL-1beta.	Sphingosine	8-19	interleukin 1 beta	Homo sapiens	241-249
26429117-9	2016	Indeed, sphingosine, which accumulates upon inhibition of SK1 activity, and sphingosine-like compounds promote activation of the inflammasome, which is linked with multiple sclerosis, to stimulate formation of the pro-inflammatory mediator, IL-1beta.	Sphingosine	76-87	interleukin 1 beta	Homo sapiens	241-249
26987326-3	2016	The present study was performed to assess the correlation between concentrations of IL-1beta, IL-6, IL-8, and TGF-beta1 in the serum with response to clarithromycin (CAM) treatment in patients with COP.	Clarithromycin	150-164	interleukin 1 beta	Homo sapiens	84-92
26987326-3	2016	The present study was performed to assess the correlation between concentrations of IL-1beta, IL-6, IL-8, and TGF-beta1 in the serum with response to clarithromycin (CAM) treatment in patients with COP.	Clarithromycin	166-169	interleukin 1 beta	Homo sapiens	84-92
26987337-4	2016	In THP1cells, grown in CS-conditioned media, the intracellular interleukins IL-1beta, IL-6, and IL-10 increased by more than tenfold, while less significant increases were found in A549 cells.	Cesium	23-25	interleukin 1 beta	Homo sapiens	76-84
27222063-6	2016	Data demonstrate that pelargonidin induced potent inhibition of PMA-, TNF-[Formula: see text]-, IL-1beta-, and CLP-induced EPCR shedding by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	pelargonidin	22-34	interleukin 1 beta	Homo sapiens	96-104
26492523-11	2016	Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	60-68
26492523-11	2016	Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression.	U 0126	9-14	interleukin 1 beta	Homo sapiens	60-68
26492523-11	2016	Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	interleukin 1 beta	Homo sapiens	60-68
26492523-11	2016	Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression.	5-7-oxo-zeaenol	29-44	interleukin 1 beta	Homo sapiens	60-68
27073697-3	2016	IL-1beta activates key degradative enzymes, including MMPs and aggrecanases, and other proinflammatory mediators such as PGE2 which contribute to ECM breakdown.	Dinoprostone	121-125	interleukin 1 beta	Homo sapiens	0-8
28078290-3	2016	Elevated NO x level was observed in patients who received the first-line disease-modifying therapy (interferons beta-1a and beta-1b) in comparison with the subjects treated with the second-line disease-modifying therapy (natalizumab; fingolimod) and healthy controls without significant differences in C-reactive protein and interleukin-1 beta.	nicotine 1-N-oxide	9-13	interleukin 1 beta	Homo sapiens	325-343
27689075-11	2016	Meanwhile, there was significant reduction in the expressions of NLRP3 and IL-1beta mRNA in groups 6.25 muM berberine and 25 muM berberine when compared with model group (P &lt; 0.05).	Berberine	108-117	interleukin 1 beta	Homo sapiens	75-83
27689075-11	2016	Meanwhile, there was significant reduction in the expressions of NLRP3 and IL-1beta mRNA in groups 6.25 muM berberine and 25 muM berberine when compared with model group (P &lt; 0.05).	Berberine	129-138	interleukin 1 beta	Homo sapiens	75-83
27689075-13	2016	Therefore, berberine alleviates monosodium urate crystals-induced inflammation by downregulating NLRP3 and IL-1beta expressions.	Berberine	11-20	interleukin 1 beta	Homo sapiens	107-115
27689075-13	2016	Therefore, berberine alleviates monosodium urate crystals-induced inflammation by downregulating NLRP3 and IL-1beta expressions.	Uric Acid	32-48	interleukin 1 beta	Homo sapiens	107-115
27181168-5	2016	RESULTS: The results from six independent experiments conducted in duplicate, showed that calcitriol decreased IL-1beta (p &lt; 0.01) and HBD-2 expression (p &lt; 0.01) when compared to non-treated cells.	Calcitriol	90-100	interleukin 1 beta	Homo sapiens	111-119
27181168-7	2016	CONCLUSION: Calcitriol prevents inflammatory gene expression, but does not affect expression of angiogenic genes in endothelial cells, which suggest the potential use of calcitriol to prevent endothelial activation through the downregulation of IL-1beta and HBD-2.	Calcitriol	170-180	interleukin 1 beta	Homo sapiens	245-253
26187854-3	2016	The stimulatory effect of sphingosine or 77-6 on LPS-stimulated IL-1beta release was reduced by pretreatment of cells with the caspase-1 inhibitor, Ac-YVAD-CHO, thereby indicating a role for the inflammasome.	Sphingosine	26-37	interleukin 1 beta	Homo sapiens	64-72
26187854-3	2016	The stimulatory effect of sphingosine or 77-6 on LPS-stimulated IL-1beta release was reduced by pretreatment of cells with the caspase-1 inhibitor, Ac-YVAD-CHO, thereby indicating a role for the inflammasome.	L 709049	148-159	interleukin 1 beta	Homo sapiens	64-72
26187854-4	2016	The enhancement of LPS-stimulated IL-1beta release in response to sphingosine, but not 77-6, was reduced by pretreatment of cells with the cathepsin B inhibitor, CA074Me, indicating a role for lysosomal destabilization in the effect of sphingosine.	Sphingosine	66-77	interleukin 1 beta	Homo sapiens	34-42
26187854-4	2016	The enhancement of LPS-stimulated IL-1beta release in response to sphingosine, but not 77-6, was reduced by pretreatment of cells with the cathepsin B inhibitor, CA074Me, indicating a role for lysosomal destabilization in the effect of sphingosine.	CA 074 methyl ester	162-169	interleukin 1 beta	Homo sapiens	34-42
26187854-4	2016	The enhancement of LPS-stimulated IL-1beta release in response to sphingosine, but not 77-6, was reduced by pretreatment of cells with the cathepsin B inhibitor, CA074Me, indicating a role for lysosomal destabilization in the effect of sphingosine.	Sphingosine	236-247	interleukin 1 beta	Homo sapiens	34-42
26622051-14	2016	Testosterone treatment also caused a significant fall in circulating concentrations of free fatty acids, C-reactive protein, interleukin-1beta, tumor necrosis factor-alpha, and leptin (P &lt; 0.05 for all).	Testosterone	0-12	interleukin 1 beta	Homo sapiens	125-171
27050175-2	2016	It is based on evidence that a continuous long-term exposure to oral bacteremia and bacterial toxins induces inflammatory immune response after immune evasion releases growth factors such as FGF, EGF, TGF-Beta, free radicals such as ROS and NOS, cytokines such as TNFAlfa, IL-1 Beta, IL-6; and matrix metalloproteinase such as MMP-9.	ros	233-236	interleukin 1 beta	Homo sapiens	273-282
26602157-3	2016	Downregulation of mRNA for IL-6, TLR-8, IL-1 beta and IL-10 was found in THP-1 cells after 4h stimulation with TNF alpha in the presence of manumycin A and downregulated TLR-8 and EGR-1 genes were observed after 8h.	manumycin	140-151	interleukin 1 beta	Homo sapiens	40-49
26602157-5	2016	Furthermore, manumycin A was found to inhibit IL-1beta, IL-6, and IL-8 production in TNF alpha stimulated THP-1 cells and peripheral blood monocytes in a dose dependent manner (0.25-1 muM of manumycin A) without affecting cell viability.	manumycin	13-24	interleukin 1 beta	Homo sapiens	46-54
26560040-0	2016	Low E-prostanoid 2 receptor levels and deficient induction of the IL-1beta/IL-1 type I receptor/COX-2 pathway: Vicious circle in patients with aspirin-exacerbated respiratory disease.	Aspirin	143-150	interleukin 1 beta	Homo sapiens	66-74
26578520-5	2016	Compared with normoxia, hypoxia significantly increased palmitate-induced mRNA expression and protein secretion of IL-6 and IL-1beta.	Palmitates	56-65	interleukin 1 beta	Homo sapiens	124-132
26881256-6	2016	Simultaneously, the mRNA and protein levels of TXNIP, NLRP3, procaspase-1, and IL-1beta were significantly induced by high glucose concentration and lipopolysaccharide in a dose-dependent and time-dependent manner in vitro.	Glucose	123-130	interleukin 1 beta	Homo sapiens	79-87
26881256-8	2016	Our results firstly reveal that high glucose and lipopolysaccharide activate ROS/TXNIP/ NLRP3/IL-1beta inflammasome signaling in glomerular mesangial cells, suggesting a mechanism by which inflammation may contribute to the development of diabetic nephropathy.	Glucose	37-44	interleukin 1 beta	Homo sapiens	94-102
26881256-8	2016	Our results firstly reveal that high glucose and lipopolysaccharide activate ROS/TXNIP/ NLRP3/IL-1beta inflammasome signaling in glomerular mesangial cells, suggesting a mechanism by which inflammation may contribute to the development of diabetic nephropathy.	Reactive Oxygen Species	77-80	interleukin 1 beta	Homo sapiens	94-102
27294162-7	2016	The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-gamma and low levels of IL-1beta and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-gamma.	mgh	40-43	interleukin 1 beta	Homo sapiens	124-132
26438054-8	2016	In addition, AG825, an inhibitor of the erbB2-associated tyrosine kinase, reduces the effect of NRG1-beta on IL-1beta-induced RhoA activation and myosin light chain phosphorylation.	tyrphostin AG825	13-18	interleukin 1 beta	Homo sapiens	109-117
26596264-11	2016	CGRP activates the cAMP-PKA-ERK signaling cascade leading to IL-1beta production.	Cyclic AMP	19-23	interleukin 1 beta	Homo sapiens	61-69
27795859-0	2016	ATP Induces Disruption of Tight Junction Proteins via IL-1 Beta-Dependent MMP-9 Activation of Human Blood-Brain Barrier In Vitro.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	54-63
27795859-4	2016	Activation of P2X7 receptor (P2X7R) by ATP induces the release of interleukin-1beta (IL-1beta), which in turn enhances the activity of matrix metalloproteinase-9 (MMP-9).	Adenosine Triphosphate	39-42	interleukin 1 beta	Homo sapiens	66-83
27795859-4	2016	Activation of P2X7 receptor (P2X7R) by ATP induces the release of interleukin-1beta (IL-1beta), which in turn enhances the activity of matrix metalloproteinase-9 (MMP-9).	Adenosine Triphosphate	39-42	interleukin 1 beta	Homo sapiens	85-93
27795859-11	2016	Further, the induction of IL-1beta and MMP-9 was closely linked to ATP/P2X7R-associated BBB leakage.	Adenosine Triphosphate	67-70	interleukin 1 beta	Homo sapiens	26-34
26705025-5	2016	High glucose also elevated IL-6 (1.8-fold), IL-1beta (1.9-fold), and TNF-alpha (1.6-fold) level, as well as induced cell apoptosis and NF-kappaB (6.1-fold) activation.	Glucose	5-12	interleukin 1 beta	Homo sapiens	44-52
26202066-6	2016	In addition, the NOD2 pathway up-regulation was functional, as stimulation of PBMCs with muramyl dipeptide (MDP) induced the production of higher amounts of tumour necrosis factor (TNF)-alpha, interleukin (IL)-8, and IL-1beta compared with OA PBMCs.	Acetylmuramyl-Alanyl-Isoglutamine	89-106	interleukin 1 beta	Homo sapiens	217-225
26612442-8	2016	Elevated levels of calcium acting via the CaSR can function as a danger signal that stimulates assembly of myeloid cell cytosolic multiprotein inflammasomes resulting in maturation of the proinflammatory cytokine IL-1beta by caspase-1.	Calcium	19-26	interleukin 1 beta	Homo sapiens	213-221
26786651-13	2016	The other cytokine levels were not significantly differ between the 2 groups.From this study we concluded that TB antigen specific IL-1beta may be an additional biomarker for active TB diagnosis among HIV positive subjects.	Terbium	111-113	interleukin 1 beta	Homo sapiens	131-139
26718437-5	2015	Ethnicity-specific meta-analysis indicated an association between the TT+TC genotype of the IL-1B 3953 C/T polymorphism and RA in Caucasians (OR = 1.243, 95% CI = 1.008-1.533, p = 0.042) and in Asians (OR = 2.672, 95% CI = 1.662-4.296, p = 4.9x10-6).	tt+tc	70-75	interleukin 1 beta	Homo sapiens	92-97
26593037-4	2015	Chicoric acid decreased the mRNA expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta.	chicoric acid	0-13	interleukin 1 beta	Homo sapiens	142-150
26641525-5	2015	Berkchaetoazaphilone B (2) inhibited IL-1beta, TNFalpha, and IL-6 production in the induced inflammasome assay and was cytotoxic toward human retinoblastoma cell line Y79 (IC50 = 1.1 muM), leukemia cell lines CCRF-CEM and SR, and the melanoma cell line LOX IMVI (IC50 = 10 muM).	berkchaetoazaphilone B	0-22	interleukin 1 beta	Homo sapiens	37-45
26546608-2	2015	The NLRP3 inflammasome mediates caspase-1 activation and subsequent IL-1beta processing in response to various stimuli, including extracellular ATP, although the roles of intracellular ATP (iATP) in NLRP3 activation remain unclear.	Adenosine Triphosphate	144-147	interleukin 1 beta	Homo sapiens	68-76
26641266-11	2015	Furthermore, we found that metformin alleviates tumor inflammation by reducing the expression of inflammatory cytokines including IL-1beta as well as infiltration and M2 polarization of tumor-associated macrophages (TAMs) in vitro and in vivo.	Metformin	27-36	interleukin 1 beta	Homo sapiens	130-138
26668503-7	2015	In HepG2 cells, PA and LPS treatment markedly increased mRNA of several nucleotide-binding and oligomerization domain-like receptor family members (NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1beta.	Palmitic Acid	16-18	interleukin 1 beta	Homo sapiens	189-197
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Calcitriol	36-46	interleukin 1 beta	Homo sapiens	246-253
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Vitamin D	62-71	interleukin 1 beta	Homo sapiens	246-253
25614126-8	2015	Incubation of cultured myofibroblasts derived from stenotic valves with sitostanol or sitosterol decreased mRNA expression of the monocyte chemotactic protein-1 (p &lt; 0.05) and interleukin-1 beta (p &lt; 0.05).	stigmastanol	72-82	interleukin 1 beta	Homo sapiens	179-197
25614126-8	2015	Incubation of cultured myofibroblasts derived from stenotic valves with sitostanol or sitosterol decreased mRNA expression of the monocyte chemotactic protein-1 (p &lt; 0.05) and interleukin-1 beta (p &lt; 0.05).	gamma-sitosterol	86-96	interleukin 1 beta	Homo sapiens	179-197
26443270-5	2015	This study investigated the antiosteoarthritis properties of an ethanol extract of SF on IL-1beta-stimulated SW1353 chondrocytes.	Ethanol	64-71	interleukin 1 beta	Homo sapiens	89-97
26443270-6	2015	SF attenuated IL-1beta-induced expression and activity of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and also reduced the elevated levels of cyclooxygenase-2 and inducible nitric oxide synthase associated with the inhibition of prostaglandin E2 and nitric oxide production in IL-1beta-stimulated SW1353 chondrocytes.	Dinoprostone	237-253	interleukin 1 beta	Homo sapiens	14-22
26443270-6	2015	SF attenuated IL-1beta-induced expression and activity of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and also reduced the elevated levels of cyclooxygenase-2 and inducible nitric oxide synthase associated with the inhibition of prostaglandin E2 and nitric oxide production in IL-1beta-stimulated SW1353 chondrocytes.	Nitric Oxide	181-193	interleukin 1 beta	Homo sapiens	14-22
26585190-6	2015	FMF patients carriers of IL-1beta(-31) CC genotype were associated with a 2-fold increase in LPS-induced IL-1beta secretion as well as a higher disease severity score (11.2 +- 2.9) when compared to patients carrying the TC and TT genotypes (6.1 +- 2.1 and 4.5 +- 2.4, respectively).	Technetium	220-222	interleukin 1 beta	Homo sapiens	25-33
26246404-0	2015	Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-beta amplification loop.	sphingosine 1-phosphate	0-23	interleukin 1 beta	Homo sapiens	33-37
26246404-2	2015	IL-1 stimulates expression of many chemokines, including C-C motif ligand (CCL) 5, that recruit immune cells, but it also stimulates sphingosine kinase-1, an enzyme that generates sphingosine-1-phosphate (S1P), a bioactive lipid mediator essential for inflammation.	sphingosine 1-phosphate	180-203	interleukin 1 beta	Homo sapiens	0-4
26392121-3	2015	Previously, we showed the role of TNF-alpha in steroid-sensitive and IL-1beta in steroid-resistant immune-mediated hearing loss.	Steroids	81-88	interleukin 1 beta	Homo sapiens	69-77
26391061-0	2015	Betulinic acid inhibits IL-1beta-induced inflammation by activating PPAR-gamma in human osteoarthritis chondrocytes.	betulinic acid	0-14	interleukin 1 beta	Homo sapiens	24-32
26391061-2	2015	In this study, we investigated the anti-osteoarthritic effects of BA in IL-1beta-stimulated human osteoarthritis chondrocytes.	betulinic acid	66-68	interleukin 1 beta	Homo sapiens	72-80
26391061-6	2015	The results showed that BA dose-dependently inhibited IL-1beta-induced MMP-1, MMP-3, MMP-13, PGE2 and NO productions.	betulinic acid	24-26	interleukin 1 beta	Homo sapiens	54-62
26391061-6	2015	The results showed that BA dose-dependently inhibited IL-1beta-induced MMP-1, MMP-3, MMP-13, PGE2 and NO productions.	Dinoprostone	93-97	interleukin 1 beta	Homo sapiens	54-62
26391061-7	2015	BA also inhibited IL-1beta-induced NF-kappaB activation.	betulinic acid	0-2	interleukin 1 beta	Homo sapiens	18-26
26391061-9	2015	In conclusion, these results suggested that BA inhibited IL-1beta-induced inflammation in osteoarthritis chondrocytes by activating PPAR-gamma.	betulinic acid	44-46	interleukin 1 beta	Homo sapiens	57-65
26395918-5	2015	Furthermore, fucosterol attenuated CoCl2 induced excess expression of IL-6, IL-1beta and TNF-alpha in HaCaT cells.	fucosterol	13-23	interleukin 1 beta	Homo sapiens	76-84
26395918-5	2015	Furthermore, fucosterol attenuated CoCl2 induced excess expression of IL-6, IL-1beta and TNF-alpha in HaCaT cells.	cobaltous chloride	35-40	interleukin 1 beta	Homo sapiens	76-84
26453510-5	2015	Levels of thymic stromal lymphopoietin, tumor necrosis factor (TNF)-alpha, IL-1beta, and IL-8 increased by IL-32 or LPS were significantly reduced by treatment with acteoside in THP-1 cells.	acteoside	165-174	interleukin 1 beta	Homo sapiens	75-83
26453510-7	2015	In IL-32-induced macrophages, acteoside significantly reduced LPS-induced TNF-alpha, IL-1beta, IL-6, and IL-8 production.	acteoside	30-39	interleukin 1 beta	Homo sapiens	85-93
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	146-153	interleukin 1 beta	Homo sapiens	72-80
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	146-153	interleukin 1 beta	Homo sapiens	203-211
26467057-7	2015	The anti-inflammatory effect of TCE was mediated via reduction of the pro-inflammatory cytokines such as: IL-1beta, TNF-alpha, IL-6, and IL-17; the frequency of IL-17-producing T cells; and the production of chemokines such as RANTES.	Trichloroethylene	32-35	interleukin 1 beta	Homo sapiens	106-114
26519528-2	2015	We report the surprising finding that HDACi promote LPS-induced IL-1beta processing and secretion in human and murine dendritic cells and murine macrophages.	hdaci	38-43	interleukin 1 beta	Homo sapiens	64-72
26175191-4	2015	Incubation of DCs with IL-1beta decreased PR expression and significantly increased PGE2 and PGF2alpha production and COX-2 expression.	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	23-31
26175191-4	2015	Incubation of DCs with IL-1beta decreased PR expression and significantly increased PGE2 and PGF2alpha production and COX-2 expression.	Dinoprost	93-102	interleukin 1 beta	Homo sapiens	23-31
26324406-7	2015	Lowering the habitually high PA intake by feeding the HOA diet resulted in lower secretion of interleukin (IL)-1beta, IL-18, IL-10, and tumor necrosis factor-alpha by PBMCs, as well as lower relative mRNA expression of cJun and NLRP3 in muscle.	Palmitic Acid	29-31	interleukin 1 beta	Homo sapiens	94-116
26407807-7	2015	Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1beta-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.	Phenformin	77-87	interleukin 1 beta	Homo sapiens	122-130
26407807-7	2015	Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1beta-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.	Prostaglandins	260-273	interleukin 1 beta	Homo sapiens	122-130
26407807-8	2015	In addition, activators of AMPK decreased skeletal muscle insulin resistance induced by LPS or IL-1beta as evidenced by increased insulin-stimulated phosphorylation of IRS-1, GLUT-4 expression and glucose uptake.	Glucose	197-204	interleukin 1 beta	Homo sapiens	95-103
26561345-6	2015	In vitro, minocycline reduced the expression of IL-1beta and inhibit the activation of nuclear factor kappa B (NF-kappaB) on peritoneal macrophages, while it had no effect on alveolar macrophages.	Minocycline	10-21	interleukin 1 beta	Homo sapiens	48-56
26384528-6	2015	In addition, high glucose concentration and fatty acids independently activate inflammasome, an intracellular multi-protein complex that promotes the proteolytic activation of caspase 1, leading to the processing and secretion of IL-1beta.	Glucose	18-25	interleukin 1 beta	Homo sapiens	230-238
26384528-6	2015	In addition, high glucose concentration and fatty acids independently activate inflammasome, an intracellular multi-protein complex that promotes the proteolytic activation of caspase 1, leading to the processing and secretion of IL-1beta.	Fatty Acids	44-55	interleukin 1 beta	Homo sapiens	230-238
26270575-0	2015	Long-chain polyunsaturated fatty acids attenuate the IL-1beta-induced proinflammatory response in human fetal intestinal epithelial cells.	long-chain polyunsaturated fatty acids	0-38	interleukin 1 beta	Homo sapiens	53-61
26270575-6	2015	RESULTS: DHA significantly attenuated IL-1beta induced proinflammatory IL-8 and IL-6 protein and mRNA in fetal H4, NEC-IEC, and mature Caco2, NCM460 IEC, compared to control and PAL treatment.	Docosahexaenoic Acids	9-12	interleukin 1 beta	Homo sapiens	38-46
26270575-6	2015	RESULTS: DHA significantly attenuated IL-1beta induced proinflammatory IL-8 and IL-6 protein and mRNA in fetal H4, NEC-IEC, and mature Caco2, NCM460 IEC, compared to control and PAL treatment.	caco2	135-140	interleukin 1 beta	Homo sapiens	38-46
26270575-7	2015	DHA downregulated IL-1R1 (IL-1beta receptor) and NFk beta1 mRNA expression in fetal and adult IEC.	Docosahexaenoic Acids	0-3	interleukin 1 beta	Homo sapiens	26-34
26545961-11	2015	The autophagy inhibitor LY290042 increased IL-1beta secretion in the presence of bacterial endotoxin LPS; IL-1beta secretion was ameliorated in the presence inflammasome inhibitors.	LY 290042	24-32	interleukin 1 beta	Homo sapiens	43-51
26545961-11	2015	The autophagy inhibitor LY290042 increased IL-1beta secretion in the presence of bacterial endotoxin LPS; IL-1beta secretion was ameliorated in the presence inflammasome inhibitors.	LY 290042	24-32	interleukin 1 beta	Homo sapiens	106-114
26341077-10	2015	Finally, we demonstrate that P2X7-induced IL-1beta secretion from lipopolysaccharide (LPS)-primed human CD14(+) monocytes was suppressed with trifluoperazine and paroxetine.	Trifluoperazine	142-157	interleukin 1 beta	Homo sapiens	42-50
26341077-10	2015	Finally, we demonstrate that P2X7-induced IL-1beta secretion from lipopolysaccharide (LPS)-primed human CD14(+) monocytes was suppressed with trifluoperazine and paroxetine.	Paroxetine	162-172	interleukin 1 beta	Homo sapiens	42-50
26494301-0	2015	Epigallocatechin-3-gallate attenuates the AIM2-induced secretion of IL-1beta in human epidermal keratinocytes.	epigallocatechin gallate	0-26	interleukin 1 beta	Homo sapiens	68-76
26494301-7	2015	Treatment with EGCG, before or after IFN-gamma priming, attenuated poly(dA:dT)-induced IL-1beta secretion in HEKn cells.	epigallocatechin gallate	15-19	interleukin 1 beta	Homo sapiens	87-95
26494301-7	2015	Treatment with EGCG, before or after IFN-gamma priming, attenuated poly(dA:dT)-induced IL-1beta secretion in HEKn cells.	Poly dA-dT	67-78	interleukin 1 beta	Homo sapiens	87-95
26494301-8	2015	Pre-treatment with EGCG reduced the level of IFN-gamma-induced priming signal via the down-regulation of pro-IL-1beta and pro-capspase-1 in HEKn cells.	epigallocatechin gallate	19-23	interleukin 1 beta	Homo sapiens	109-117
26494301-10	2015	These results suggest that EGCG attenuates AIM2-induced IL-1beta secretion by suppressing both IFN-gamma-mediated priming and poly(dA:dT)-induced ASC oligomerization of inflammasomes in human epidermal keratinocytes.	epigallocatechin gallate	27-31	interleukin 1 beta	Homo sapiens	56-64
26494301-10	2015	These results suggest that EGCG attenuates AIM2-induced IL-1beta secretion by suppressing both IFN-gamma-mediated priming and poly(dA:dT)-induced ASC oligomerization of inflammasomes in human epidermal keratinocytes.	poly	126-130	interleukin 1 beta	Homo sapiens	56-64
26494301-10	2015	These results suggest that EGCG attenuates AIM2-induced IL-1beta secretion by suppressing both IFN-gamma-mediated priming and poly(dA:dT)-induced ASC oligomerization of inflammasomes in human epidermal keratinocytes.	amsonic acid	131-133	interleukin 1 beta	Homo sapiens	56-64
26494301-10	2015	These results suggest that EGCG attenuates AIM2-induced IL-1beta secretion by suppressing both IFN-gamma-mediated priming and poly(dA:dT)-induced ASC oligomerization of inflammasomes in human epidermal keratinocytes.	Thymidine	134-136	interleukin 1 beta	Homo sapiens	56-64
26610473-5	2015	Inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and intracellular NFkappaB were measured after 24 h. The steatosis was significantly decreased after Gardenoside treatment without cytotoxicity.	gardenoside	150-161	interleukin 1 beta	Homo sapiens	34-42
26610473-6	2015	TNF-alpha, IL-1beta, IL-6 were modulated to HepG2 cells by treatment of Gardenoside.	gardenoside	72-83	interleukin 1 beta	Homo sapiens	11-19
26462152-9	2015	Neutralizing antibodies against IL-1beta or CXCL1 markedly inhibited the constitutive or IL-1beta-induced tyrosine phosphorylation of EGFR in OSCC cells.	Tyrosine	106-114	interleukin 1 beta	Homo sapiens	89-97
26341906-7	2015	Further, ACR stimulated increase in levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible form of nitric oxide synthase (iNOS) were considerably decreased by farnesol.	Acrylamide	9-12	interleukin 1 beta	Homo sapiens	122-139
26558438-7	2015	Quercitrin decreased the release of the inflammatory mediator PGE2 and partially re-established the impaired collagen metabolism induced by IL-1beta treatment in hGFs.	quercitrin	0-10	interleukin 1 beta	Homo sapiens	140-148
26335060-0	2015	Involvement of nitric oxide in the induction of interleukin-1 beta in microglia.	Nitric Oxide	15-27	interleukin 1 beta	Homo sapiens	48-66
26335060-1	2015	In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1beta) together with nitric oxide (NO) and superoxide anion (O2(-)).	Superoxides	212-214	interleukin 1 beta	Homo sapiens	148-156
26335060-2	2015	Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1beta is induced in microglia.	Superoxides	40-42	interleukin 1 beta	Homo sapiens	82-90
26335060-3	2015	The LPS-inducible IL-1beta was significantly suppressed by pretreatment with the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide, but not by pretreatment with the O2(-) scavenger N-acetyl cysteine, suggesting the close association of NO with IL-1beta induction.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	94-159	interleukin 1 beta	Homo sapiens	18-26
26335060-3	2015	The LPS-inducible IL-1beta was significantly suppressed by pretreatment with the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide, but not by pretreatment with the O2(-) scavenger N-acetyl cysteine, suggesting the close association of NO with IL-1beta induction.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	94-159	interleukin 1 beta	Homo sapiens	273-281
26335060-3	2015	The LPS-inducible IL-1beta was significantly suppressed by pretreatment with the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide, but not by pretreatment with the O2(-) scavenger N-acetyl cysteine, suggesting the close association of NO with IL-1beta induction.	Superoxides	194-196	interleukin 1 beta	Homo sapiens	18-26
26335060-3	2015	The LPS-inducible IL-1beta was significantly suppressed by pretreatment with the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide, but not by pretreatment with the O2(-) scavenger N-acetyl cysteine, suggesting the close association of NO with IL-1beta induction.	Acetylcysteine	210-227	interleukin 1 beta	Homo sapiens	18-26
26335060-4	2015	The pretreatment of microglia with the inducible NO synthase inhibitor 1400W prior to LPS stimulation significantly reduced the production of IL-1beta, and the addition of the NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP) into microglia led to the induction of IL-1beta.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	71-76	interleukin 1 beta	Homo sapiens	142-150
26335060-4	2015	The pretreatment of microglia with the inducible NO synthase inhibitor 1400W prior to LPS stimulation significantly reduced the production of IL-1beta, and the addition of the NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP) into microglia led to the induction of IL-1beta.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	71-76	interleukin 1 beta	Homo sapiens	267-275
26803500-4	2016	Here, we review evidence that the release of neuroactive cytokines, particularly interleukins such as IL-1beta, IL-6, and TNF-alpha, is altered in these disorders and discuss mechanisms such as the ATP-gated ion channel P2X7, through which cytokine signaling can influence neuro-glial interactions.	Adenosine Triphosphate	198-201	interleukin 1 beta	Homo sapiens	102-110
27128935-5	2016	Inflammatory mediators, such as TNF-alpha and IL-1beta, are induced by saturated fatty acids and disrupt insulin signaling.	Fatty Acids	71-92	interleukin 1 beta	Homo sapiens	46-54
26786104-8	2016	BMDMs treated with soluble but not fibrillar IAPP provided a TLR2-dependent priming stimulus for ATP-induced IL-1beta secretion, whereas late IAPP aggregates induced NLRP3-dependent IL-1beta secretion by LPS-primed macrophages.	Adenosine Triphosphate	97-100	interleukin 1 beta	Homo sapiens	109-117
27090981-8	2016	Furthermore, HM71224 effectively inhibited the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta by human monocytes, and osteoclast formation by human monocytes.	Poseltinib	13-20	interleukin 1 beta	Homo sapiens	120-128
26951799-4	2016	We demonstrate that ATP acting via the P2X7 receptor pathway promotes a Th17 polarizing microenvironment with high levels of IL-1beta, IL-6, and IL-17 in VAT explants from lean donors.	Adenosine Triphosphate	20-23	interleukin 1 beta	Homo sapiens	125-133
27699257-3	2016	In the present work, we find that the ability of IL-1beta to amplify glucose-stimulated insulin secretion from human islets correlates with donor BMI.	Glucose	69-76	interleukin 1 beta	Homo sapiens	49-57
27055013-7	2016	DYN 1-17 and selected fragments demonstrated differential modulation on the release of IL-1beta and TNF-alpha with significant inhibition observed with DYN 1-7 at low concentrations (1 nM and 10 pM).	dyn 1-7	152-159	interleukin 1 beta	Homo sapiens	87-95
27044314-3	2016	The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Beta, MCP1, ALOX5, PTGS2, MGST1 and NOS2) related to inflammation in unstimulated cultured THP1 macrophages.	Eicosapentaenoic Acid	52-55	interleukin 1 beta	Homo sapiens	140-147
27044314-7	2016	Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1.	Eicosapentaenoic Acid	50-53	interleukin 1 beta	Homo sapiens	107-114
27044314-7	2016	Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1.	Docosahexaenoic Acids	56-59	interleukin 1 beta	Homo sapiens	107-114
25649144-7	2016	RESULTS: The production of interleukin (IL)-1beta and IL-6 was higher in patients compared with controls and this correlated with serum urate levels.	Uric Acid	136-141	interleukin 1 beta	Homo sapiens	27-49
25649144-12	2016	CONCLUSIONS: In this study we demonstrate a mechanism through which high concentrations of uric acid (up to 50 mg/dL) influence inflammatory responses by facilitating IL-1beta production in PBMCs.	Uric Acid	91-100	interleukin 1 beta	Homo sapiens	167-175
26306587-14	2016	Clinoptilolite counteracted the apoptosis and inflammation induced by ADR arising from the decrease in NF-kappaB, TNF-alpha, and IL-1beta protein levels.	clinoptilolite	0-14	interleukin 1 beta	Homo sapiens	129-137
27886801-5	2016	Clarification of the molecular pathogenic mechanisms of FMF has revealed that interleukin-1 beta (IL-1beta) cytokine is the most likely target to attack, and several case reports and case series have already documented the efficacy and safety of available anti-IL-1 agents, such as anakinra, rilonacept, and canakinumab in those patients inadequately responding to colchicine.	Colchicine	365-375	interleukin 1 beta	Homo sapiens	78-96
27886801-5	2016	Clarification of the molecular pathogenic mechanisms of FMF has revealed that interleukin-1 beta (IL-1beta) cytokine is the most likely target to attack, and several case reports and case series have already documented the efficacy and safety of available anti-IL-1 agents, such as anakinra, rilonacept, and canakinumab in those patients inadequately responding to colchicine.	Colchicine	365-375	interleukin 1 beta	Homo sapiens	98-106
27073620-1	2016	Technetium 99 conjugated with methylene diphosphonate, which is an anti-inflammatory drug, can inhibit macrophage infiltration and downregulate a number of proinflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-1beta.	Technetium-99	0-13	interleukin 1 beta	Homo sapiens	223-240
27073620-1	2016	Technetium 99 conjugated with methylene diphosphonate, which is an anti-inflammatory drug, can inhibit macrophage infiltration and downregulate a number of proinflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-1beta.	methylene diphosphonate	30-53	interleukin 1 beta	Homo sapiens	223-240
26858093-8	2016	The ability of a clinico-genetic model incorporating the two IL1B polymorphisms to classify patients at risk for developing prolonged postoperative QTc was superior to a clinical model alone, with a net reclassification improvement of 0.308 (P = 0.0003) and an integrated discrimination improvement of 0.02 (P = 0.000024).	qtc	148-151	interleukin 1 beta	Homo sapiens	61-65
26945994-5	2016	And the promotion to TNF-alpha and IL-1beta was confirmed in vitro in both mRNA and protein levels in high glucose-treated MG-63 cells.	Glucose	107-114	interleukin 1 beta	Homo sapiens	35-43
26923246-7	2016	Oridonin inhibited cell proliferation and induced cell apoptosis in interleukin-1beta (IL-1beta)-treated FLS.	oridonin	0-8	interleukin 1 beta	Homo sapiens	68-85
26923246-7	2016	Oridonin inhibited cell proliferation and induced cell apoptosis in interleukin-1beta (IL-1beta)-treated FLS.	oridonin	0-8	interleukin 1 beta	Homo sapiens	87-95
26923246-9	2016	Oridonin suppressed IL-1beta-mediated phosphorylation of ERK1/2 and JNK in a dose-dependent manner.	oridonin	0-8	interleukin 1 beta	Homo sapiens	20-28
26923246-14	2016	Oridonin inhibits cell proliferation, induces cell apoptosis, and decreases the phosphorylation of ERK1/2 and JNK in IL-1beta-exposed RAFLS.	oridonin	0-8	interleukin 1 beta	Homo sapiens	117-125
26865578-3	2016	Baicalin at 50 microg/ml and 100 microg/ml could inhibit the production of ROS, TNF-alpha, IL-1beta and IL-18, and down-regulate mRNA expression of IL-1beta, IL-18, TNF-alpha and NLRP3, as well as expression of cleaved caspase-1 p20.	baicalin	0-8	interleukin 1 beta	Homo sapiens	91-99
26865578-3	2016	Baicalin at 50 microg/ml and 100 microg/ml could inhibit the production of ROS, TNF-alpha, IL-1beta and IL-18, and down-regulate mRNA expression of IL-1beta, IL-18, TNF-alpha and NLRP3, as well as expression of cleaved caspase-1 p20.	baicalin	0-8	interleukin 1 beta	Homo sapiens	148-156
26179241-3	2016	The cranberry contains anti-inflammatory polyphenols, which inhibit proinflammatory activities of lipopolysaccharide (LPS)- and IL-1beta-stimulated human cells.	Polyphenols	41-52	interleukin 1 beta	Homo sapiens	128-136
27034605-10	2016	Moreover, Bay 11-7082 also inhibited IL-1beta-induced expression of COX-2 and production of PGE2.	3-(4-methylphenylsulfonyl)-2-propenenitrile	10-21	interleukin 1 beta	Homo sapiens	37-45
27034605-10	2016	Moreover, Bay 11-7082 also inhibited IL-1beta-induced expression of COX-2 and production of PGE2.	Dinoprostone	92-96	interleukin 1 beta	Homo sapiens	37-45
27034605-11	2016	The inhibitory effect of lactoferrin on the IL-1beta induced expression of COX-2 or production of PGE2 was mediated at least in part via suppression of NF-kappaB activation.	Dinoprostone	98-102	interleukin 1 beta	Homo sapiens	44-52
26811545-7	2016	Knockdown of RAF1 by siRNA in primary myometrial cells significantly decreased IL1B- and TNF-induced IL1A, IL1B, IL6, (C-X-C motif) ligand 8 (CXCL8)and chemokine (C-C motif) ligand 2 (CCL2) mRNA abundance and IL6, IL8 and CCL2; prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA levels and prostaglandin PGF2 alpha release; and NF-kappaB activation.	Prostaglandins	228-241	interleukin 1 beta	Homo sapiens	79-83
26811545-9	2016	Concordantly, the ERK inhibitor U0126 significantly decreased IL1B-induced IL6, CXCL8, CCL2 and PTGS2 mRNA abundance; IL6, CXCL8, CCL2 and PGF2 alpha release; and NF-kappaB activation.	U 0126	32-37	interleukin 1 beta	Homo sapiens	62-66
26811545-9	2016	Concordantly, the ERK inhibitor U0126 significantly decreased IL1B-induced IL6, CXCL8, CCL2 and PTGS2 mRNA abundance; IL6, CXCL8, CCL2 and PGF2 alpha release; and NF-kappaB activation.	Dinoprost	139-143	interleukin 1 beta	Homo sapiens	62-66
26809137-6	2016	Moreover, knockdown of NLRP3 by small interfering RNA efficiently suppressed Cd-induced caspase-1 cleavage, IL-1beta production and pyroptosis in HUVECs.	Cadmium	77-79	interleukin 1 beta	Homo sapiens	108-116
26974319-6	2016	Pretreating THP-1 cells with folic acid attenuated hypoxia-induced inflammatory responses, including a decrease in protein and mRNA levels of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha), coupled with increased levels of IL-10.	Folic Acid	29-39	interleukin 1 beta	Homo sapiens	142-164
27170844-0	2016	The effect of PEGylation on the stimulation of IL-1beta by gold (Au) nanoshell/silica core nanoparticles.	Silicon Dioxide	79-85	interleukin 1 beta	Homo sapiens	47-55
27170844-2	2016	In this study, we compared the ability of bare (GNS) and PEGylated Au nanoshell/silica core (PEG-GNS) nanoparticles in stimulating the production of IL-1beta in both macrophage cell lines.	Gold	67-69	interleukin 1 beta	Homo sapiens	149-157
27170844-2	2016	In this study, we compared the ability of bare (GNS) and PEGylated Au nanoshell/silica core (PEG-GNS) nanoparticles in stimulating the production of IL-1beta in both macrophage cell lines.	Silicon Dioxide	80-86	interleukin 1 beta	Homo sapiens	149-157
27170844-2	2016	In this study, we compared the ability of bare (GNS) and PEGylated Au nanoshell/silica core (PEG-GNS) nanoparticles in stimulating the production of IL-1beta in both macrophage cell lines.	peg-gns	93-100	interleukin 1 beta	Homo sapiens	149-157
27170844-9	2016	The excess of ROS induced by GNS potentially caused the activation of inflammasomes, and thus the secretion of IL-1beta.	Reactive Oxygen Species	14-17	interleukin 1 beta	Homo sapiens	111-119
26944557-0	2016	Interleukin-1beta mediates high glucose induced phenotypic transition in human aortic endothelial cells.	Glucose	32-39	interleukin 1 beta	Homo sapiens	0-17
26944557-19	2016	The PKCbeta activation may mediate the effect of the HG on IL-1beta production, which could be attenuated by the PKCbeta selective inhibitor (LY317615) (P &lt; 0.05).	enzastaurin	142-150	interleukin 1 beta	Homo sapiens	59-67
26937017-7	2016	The administration of exogenous IL-1beta and TNF-alpha to brain-injured animals worsened Evans Blue dye extravasation, suggesting that systemic inflammation contributes to TBI-triggered BBB permeability.	Evans Blue	89-103	interleukin 1 beta	Homo sapiens	32-40
26784009-4	2016	PEG modification significantly enhanced BMDC activation marker up-regulation and IL-1beta production in vitro, and innate immune cell infiltration in vivo.	Polyethylene Glycols	0-3	interleukin 1 beta	Homo sapiens	81-89
26908433-6	2016	Saturated fat intake was associated with increased CRP, sTNFRII, TNFalpha, and IL1beta, whereas eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) intake (diet or total) was associated with decreased CRP, TNFalpha, and IL1beta.	Fatty Acids, Omega-3	0-13	interleukin 1 beta	Homo sapiens	79-86
26718495-7	2016	Furthermore, SAT ceramide concentrations correlated with the expression of CASP1 and IL1B.	Ceramides	17-25	interleukin 1 beta	Homo sapiens	85-89
26803522-7	2016	Meanwhile, a reduction in the serum levels of IL-1beta, MDA and S-100B was noticed in progesterone group 24h after injury (P&lt;0.05, P&lt;0.001 and P&lt;0.05, respectively), and there was an increase in serum levels of IL-6 and TGF-beta1 (P&lt;0.01 and P&lt;0.05, respectively).	Progesterone	86-98	interleukin 1 beta	Homo sapiens	46-54
28250974-0	2016	Effect of scaling and root planing with and without adjunct use of an essential-oil-based mouthwash on whole salivary interleukin-1beta levels in patients with periodontal disease: A short-term follow-up study.	Oils, Volatile	70-83	interleukin 1 beta	Homo sapiens	118-135
26640965-6	2016	Our study shows that tianeptine attenuated the LPS-evoked inflammatory activation of microglia by decreasing the expression of proinflammatory cytokines such as IL-1beta, IL-18, IL-6 and tumor necrosis factor alpha (TNF-alpha), the release of nitric oxide (NO) and reactive oxygen species (ROS) as well as the expression of inducible nitric oxide synthase.	tianeptine	21-31	interleukin 1 beta	Homo sapiens	161-169
26796050-5	2016	The results demonstrated that a high concentration of calcium ions in seawater increased lung tissue myeloperoxidase activity and the secretion of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta and IL-6.	Calcium	54-61	interleukin 1 beta	Homo sapiens	223-245
26796050-7	2016	The elevated [Ca2+c] may have resulted in the increased release of TNF-alpha and IL-1beta via increased phosphorylation of nuclear factor-kappaB (NF-kappaB).	ca2+c	14-19	interleukin 1 beta	Homo sapiens	81-89
26796050-9	2016	Calcium influx through TRPV1 may have led to greater phosphorylation of NF-kappaB and increased release of TNF-alpha and IL-1beta.	Calcium	0-7	interleukin 1 beta	Homo sapiens	121-129
26908203-11	2016	The cytokine Interleukin-1beta (IL-1beta) at 1 ng/ml significantly potentiated the expression of both IL-8 (CXCL8) and MCP-1 (CCL2) which showed synergistic response in the presence of hydrogen peroxide.	Hydrogen Peroxide	185-202	interleukin 1 beta	Homo sapiens	13-30
26908203-11	2016	The cytokine Interleukin-1beta (IL-1beta) at 1 ng/ml significantly potentiated the expression of both IL-8 (CXCL8) and MCP-1 (CCL2) which showed synergistic response in the presence of hydrogen peroxide.	Hydrogen Peroxide	185-202	interleukin 1 beta	Homo sapiens	32-40
26908203-12	2016	Pre-incubation of the cells with the anti-oxidant N-acetyl cysteine (NAC) strongly suppressed the induction of both IL-8 and MCP-1 when stimulated with hydrogen peroxide and IL-1beta.	Acetylcysteine	50-67	interleukin 1 beta	Homo sapiens	174-182
26908203-12	2016	Pre-incubation of the cells with the anti-oxidant N-acetyl cysteine (NAC) strongly suppressed the induction of both IL-8 and MCP-1 when stimulated with hydrogen peroxide and IL-1beta.	Acetylcysteine	69-72	interleukin 1 beta	Homo sapiens	174-182
27236883-12	2016	CONCLUSION: Dexmedetomidine combied electrical stimulation could effectively prevent the occurrence of postoperative cognition, and reduce levels of NSA, S-100beta, IL-1beta, IL-6 and TNF-alpha.	Dexmedetomidine	12-27	interleukin 1 beta	Homo sapiens	165-173
26896068-9	2016	Moreover, metformin enhanced the anti-inflammatory effect of 5-ASA by decreasing the gene expression of IL-1beta, IL-6, COX-2 and TNF-alpha and its receptors; TNF-R1 and TNF-R2.	Metformin	10-19	interleukin 1 beta	Homo sapiens	104-112
26896068-9	2016	Moreover, metformin enhanced the anti-inflammatory effect of 5-ASA by decreasing the gene expression of IL-1beta, IL-6, COX-2 and TNF-alpha and its receptors; TNF-R1 and TNF-R2.	Mesalamine	61-66	interleukin 1 beta	Homo sapiens	104-112
26723515-4	2016	The results showed that treatment of eriodictyol inhibited the production of blood urea nitrogen (BUN), creatinine, MDA, TBARS, reactive oxygen species (ROS), as well as the production of TNF-alpha, and IL-1beta in kidney tissues induced by CP.	eriodictyol	37-48	interleukin 1 beta	Homo sapiens	203-211
26848751-0	2016	The Effect of (-)-Epigallocatechin-3-Gallate on IL-1beta Induced IL-8 Expression in Orbital Fibroblast from Patients with Thyroid-Associated Ophthalmopathy.	epigallocatechin gallate	14-44	interleukin 1 beta	Homo sapiens	48-56
26848751-4	2016	In the current study, we investigated the issue of whether or how EGCG affects the interleukin (IL)-1beta-induced secretion of IL-8 in human orbital fibroblasts from TAO patients.	epigallocatechin gallate	66-70	interleukin 1 beta	Homo sapiens	83-105
26848751-5	2016	Treatment with EGCG significantly reduced the level of IL-1beta-induced secretion of IL-8 and the expression of IL-8 mRNA.	epigallocatechin gallate	15-19	interleukin 1 beta	Homo sapiens	55-63
26848751-6	2016	IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK.	BAY 11-7085	185-195	interleukin 1 beta	Homo sapiens	0-8
26848751-6	2016	IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK.	BAY 11-7085	185-195	interleukin 1 beta	Homo sapiens	98-106
26848751-6	2016	IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK.	SB 203580	207-215	interleukin 1 beta	Homo sapiens	0-8
26848751-6	2016	IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK.	SB 203580	207-215	interleukin 1 beta	Homo sapiens	98-106
26848751-6	2016	IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	229-236	interleukin 1 beta	Homo sapiens	0-8
26848751-6	2016	IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	229-236	interleukin 1 beta	Homo sapiens	98-106
26848751-7	2016	In addition, treatment with EGCG inhibited the IL-1beta-induced degradation of IkappaBalpha, and the phosphorylation of p38 and ERK.	epigallocatechin gallate	28-32	interleukin 1 beta	Homo sapiens	47-55
26848751-9	2016	These results show that EGCG suppresses the IL-1beta-induced expression of IL-8 through inhibition of the NF-kappaB, p38, and ERK pathways.	epigallocatechin gallate	24-28	interleukin 1 beta	Homo sapiens	44-52
26862462-6	2016	All ADSCs evaluated also responded to dHACM treatment with altered expression of immunomodulatory genes, including interleukins (IL)-1alpha, IL-1beta, and IL-1RA.	dhacm	38-43	interleukin 1 beta	Homo sapiens	141-149
26673543-4	2016	The results showed that the PPAR-gamma agonist pioglitazone decreased the expression of NF-kappaB p65 transcription target genes (e.g., IL-6, IL-1beta, and TNF-alpha) and inhibited histological injury and inflammatory cells infiltration in cisplatin nephrotoxicity.	Pioglitazone	47-59	interleukin 1 beta	Homo sapiens	142-150
26674566-9	2016	IL1B-, fsl-1-, and poly (I:C)-induced PTGS2 mRNA expression and IL1B-induced prostaglandin release was also decreased by IRF1 silencing.	Prostaglandins	77-90	interleukin 1 beta	Homo sapiens	64-68
26583279-7	2016	RESULTS: The results indicated that minocycline inhibited inflammation, decreased the expression of interleukin-1beta, tumor necrosis factor-alpha, and metalloproteinase -9, and squamous metaplasia features such as hyperproliferation and abnormal epidermal differentiation of conjunctival epithelium.	Minocycline	36-47	interleukin 1 beta	Homo sapiens	100-146
26671765-5	2016	The incorporation of UDCA with PSS, PAA and WSG enhanced cell viability per microcapsule (p &lt; 0.05), cellular metabolic profile (p &lt; 0.01) and insulin production (p &lt; 0.01); reduced the inflammatory release TNF-alpha (p &lt; 0.01), INF-gamma (p &lt; 0.01) and interleukin-6 (IL-6) (p &lt; 0.01); and ceased the production of IL-1beta.	pss	31-34	interleukin 1 beta	Homo sapiens	334-342
26577567-6	2016	Stimulation of lipopolysaccharide-primed peripheral blood mononuclear cells with ferric ammonium citrate increases the level of cellular Fe(2+) levels in monocytes and induces production of interleukin-1beta in a dose-dependent manner.	ferric ammonium citrate	81-104	interleukin 1 beta	Homo sapiens	190-207
26577567-7	2016	This ferric ammonium citrate-induced interleukin-1beta production is dependent on caspase-1 and is significantly inhibited by an Fe(2+)-specific chelator.	ferric ammonium citrate	5-28	interleukin 1 beta	Homo sapiens	37-54
26577567-7	2016	This ferric ammonium citrate-induced interleukin-1beta production is dependent on caspase-1 and is significantly inhibited by an Fe(2+)-specific chelator.	ammonium ferrous sulfate	129-135	interleukin 1 beta	Homo sapiens	37-54
26577567-8	2016	Ferric ammonium citrate consistently induced interleukin-1beta secretion in THP1 cells, but not in NLRP3-deficient THP1 cells, indicating a requirement for the NLRP3 inflammasome.	ferric ammonium citrate	0-23	interleukin 1 beta	Homo sapiens	45-62
26825654-6	2016	Furthermore, we observed that ATG5 and Beclin1 downregulation sensitised cells to IL-1beta release induced by MSU or nigericin, which is an NLRP3 inflammasome activator.	Nigericin	117-126	interleukin 1 beta	Homo sapiens	82-90
26893624-8	2016	Following treatment with various concentrations of puerarin, the expression levels of IL-1beta and TNF-alpha were markedly blunted, particularly in the LPS + 40 microM puerarin group (P&lt;0.05 vs. the LPS group).	puerarin	51-59	interleukin 1 beta	Homo sapiens	86-94
26893624-8	2016	Following treatment with various concentrations of puerarin, the expression levels of IL-1beta and TNF-alpha were markedly blunted, particularly in the LPS + 40 microM puerarin group (P&lt;0.05 vs. the LPS group).	puerarin	168-176	interleukin 1 beta	Homo sapiens	86-94
26454448-1	2016	This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production.	rebamipide	38-48	interleukin 1 beta	Homo sapiens	198-206
26454448-1	2016	This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production.	Reactive Oxygen Species	107-130	interleukin 1 beta	Homo sapiens	179-196
26454448-1	2016	This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production.	Reactive Oxygen Species	132-135	interleukin 1 beta	Homo sapiens	179-196
26454448-1	2016	This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production.	Uric Acid	140-156	interleukin 1 beta	Homo sapiens	179-196
26454448-1	2016	This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production.	Uric Acid	140-156	interleukin 1 beta	Homo sapiens	198-206
26454448-1	2016	This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production.	Uric Acid	158-161	interleukin 1 beta	Homo sapiens	179-196
26454448-1	2016	This study investigated the effect of rebamipide on activation of the NLRP3 inflammasome and generation of reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1beta (IL-1beta) production.	Uric Acid	158-161	interleukin 1 beta	Homo sapiens	198-206
26454448-6	2016	In THP-1 cells, treatment with MSU crystals increased NADP/NADPH ratios and IL-1beta expression, and both of these responses were potently inhibited by addition of rebamipide.	Uric Acid	31-34	interleukin 1 beta	Homo sapiens	76-84
26454448-6	2016	In THP-1 cells, treatment with MSU crystals increased NADP/NADPH ratios and IL-1beta expression, and both of these responses were potently inhibited by addition of rebamipide.	rebamipide	164-174	interleukin 1 beta	Homo sapiens	76-84
26454448-11	2016	This study demonstrated that rebamipide inhibits IL-1beta activation through suppression of ROS-mediated NF-kappaB signaling pathways and caspase-1 activation in MSU crystal-induced inflammation.	rebamipide	29-39	interleukin 1 beta	Homo sapiens	49-57
26454448-11	2016	This study demonstrated that rebamipide inhibits IL-1beta activation through suppression of ROS-mediated NF-kappaB signaling pathways and caspase-1 activation in MSU crystal-induced inflammation.	Reactive Oxygen Species	92-95	interleukin 1 beta	Homo sapiens	49-57
26677054-8	2016	Treating A549 cells with either EtOH or EtP significantly reduced the IL-1beta- or TNF-induced IL-8 release, whereas treating Huh7 cells did not significantly alter IL-6 release.	Ethanol	32-36	interleukin 1 beta	Homo sapiens	70-78
26677054-8	2016	Treating A549 cells with either EtOH or EtP significantly reduced the IL-1beta- or TNF-induced IL-8 release, whereas treating Huh7 cells did not significantly alter IL-6 release.	ethyl pyruvate	40-43	interleukin 1 beta	Homo sapiens	70-78
26748475-7	2016	PGC-1beta inhibited PA induced TNFalpha, MCP-1, and IL-1beta mRNA and protein expressions.	Palmitic Acid	20-22	interleukin 1 beta	Homo sapiens	52-60
26830368-13	2016	The mechanism of IL-17A-triggered NLRP3 activation and subsequent IL-1beta secretion was found to involve the generation of reactive oxygen species.	Reactive Oxygen Species	124-147	interleukin 1 beta	Homo sapiens	66-74
26398164-12	2016	After the addition of atorvastatin, IL-1beta or NF-kappaB luciferase reporter expression level decreased.	Atorvastatin	22-34	interleukin 1 beta	Homo sapiens	36-44
26701795-10	2016	GOS reduced TNF-alpha- and IL-1beta-induced inflammatory responses to 25-26% and pathogen-induced IL-8 and MCP-1 to 36-39% of positive controls (P &lt; 0.001).	D-Glucitol-1,6-bisphosphate	0-3	interleukin 1 beta	Homo sapiens	27-35
27141626-14	2016	CONCLUSION: Acupoint injection of Lidocaine is effective in relieving pain in LC patients, which is demonstrated by reducing VAS score, PCA pump pressing times, and administrated Sufentanil dose, and may be associated with its effects in down-regulating serum TNF-alpha and IL-1beta contents.	Lidocaine	34-43	interleukin 1 beta	Homo sapiens	274-282
26694802-6	2016	RA significantly reduced the production of tumor necrosis factor-alpha, IL-1beta, and IL-6 on the TSLP-stimulated HMC-1 cells.	rosmarinic acid	0-2	interleukin 1 beta	Homo sapiens	72-80
26555265-4	2016	We observed QS-21 to elicit caspase-1-dependent IL-1beta and IL-18 release in antigen-presenting cells such as macrophages and dendritic cells when co-stimulated with the TLR4-agonist adjuvant monophosphoryl lipid A.	saponin QA-21V1	12-17	interleukin 1 beta	Homo sapiens	48-56
26762881-5	2016	The addition of PS significantly reduced the expression of pro-inflammatory mediators, TNF-alpha, IL-1 beta, IL-6, MMP-2 and MMP-9 in HCECs exposed to hyperosmotic medium.	pterostilbene	16-18	interleukin 1 beta	Homo sapiens	98-107
27535254-5	2016	Monosodium urate crystals act as danger activating molecular patterns (DAMPs), activating the inflammasome and inducing the secretion of IL-1beta, a key mediator of the inflammatory response.	Uric Acid	0-16	interleukin 1 beta	Homo sapiens	137-145
27771935-4	2016	Eucalyptol suppresses lipopolysaccharide (LPS)-induced proinflammatory cytokine production through the action of NF-kappaB, TNF-alpha, IL-1beta, and IL-6 and the extracellular signal-regulated kinase (ERK) pathway, and reduces oxidative stress through the regulation of signaling pathways and radical scavenging.	Eucalyptol	0-10	interleukin 1 beta	Homo sapiens	135-143
26613509-6	2016	Incubation of cells with the specific AhR-inducer benzo[a]anthracene resulted in an upregulation of CYP and IL-1beta mRNA expression in primary monocytes and iDC.	anthracene	58-68	interleukin 1 beta	Homo sapiens	108-116
26613509-7	2016	CYP1A1 but not CYP1B1 and IL-1beta expression was increased by benzo[a]anthracene in these cell lines except for U937 cells.	benz(a)anthracene	63-81	interleukin 1 beta	Homo sapiens	26-34
25261578-9	2016	The anti-inflammatory agents, colchicine and DNAse I, inhibited IL-1beta production in PMNs and IL-1beta activity in NETs, respectively.	Colchicine	30-40	interleukin 1 beta	Homo sapiens	64-72
25261578-9	2016	The anti-inflammatory agents, colchicine and DNAse I, inhibited IL-1beta production in PMNs and IL-1beta activity in NETs, respectively.	Colchicine	30-40	interleukin 1 beta	Homo sapiens	96-104
26492523-2	2016	IL-1beta stimulates cyclooxygenase-2 (COX-2) and prostaglandins production of pulp cells and affects the pulpal inflammation and repair.	Prostaglandins	49-63	interleukin 1 beta	Homo sapiens	0-8
27221874-11	2016	IL-1B and IL-1RN genotypes were demonstrated as 21.4% for CC, 48.1% for TC, 36.8% for TT, 72.7% for 1/1, and 21.2% for 1/2 genotypes, respectively.	Technetium	72-74	interleukin 1 beta	Homo sapiens	0-5
27251500-5	2016	In addition, ferulic acid and kaempferol showed inhibition against interleukin-8 (IL-8) and interleukin-1beta (IL-1beta) expression while ferulic acid and caffeic acid showed comparatively higher inhibition of ED associated tumor necrosis factor-alpha (TNF-alpha) expression.	ferulic acid	13-25	interleukin 1 beta	Homo sapiens	92-109
27251500-5	2016	In addition, ferulic acid and kaempferol showed inhibition against interleukin-8 (IL-8) and interleukin-1beta (IL-1beta) expression while ferulic acid and caffeic acid showed comparatively higher inhibition of ED associated tumor necrosis factor-alpha (TNF-alpha) expression.	ferulic acid	13-25	interleukin 1 beta	Homo sapiens	111-119
27251500-5	2016	In addition, ferulic acid and kaempferol showed inhibition against interleukin-8 (IL-8) and interleukin-1beta (IL-1beta) expression while ferulic acid and caffeic acid showed comparatively higher inhibition of ED associated tumor necrosis factor-alpha (TNF-alpha) expression.	kaempferol	30-40	interleukin 1 beta	Homo sapiens	92-109
27251500-5	2016	In addition, ferulic acid and kaempferol showed inhibition against interleukin-8 (IL-8) and interleukin-1beta (IL-1beta) expression while ferulic acid and caffeic acid showed comparatively higher inhibition of ED associated tumor necrosis factor-alpha (TNF-alpha) expression.	kaempferol	30-40	interleukin 1 beta	Homo sapiens	111-119
26648474-6	2016	This biogenic amine shows age-and sex-dependent changes in the CNS, and is significantly altered, together with interleukin- 1beta and TNF-alpha, in Alzheimer"s disease and other neurodegenerative disorders in which neuroinflammation appears to be an aggravating phenotype.	Amines	14-19	interleukin 1 beta	Homo sapiens	112-130
27807462-0	2016	Essential Oils from Ugandan Medicinal Plants: In Vitro Cytotoxicity and Effects on IL-1beta-Induced Proinflammatory Mediators by Human Gingival Fibroblasts.	Oils, Volatile	0-14	interleukin 1 beta	Homo sapiens	83-91
27807462-5	2016	Baseline and IL-1beta-induced secretion of PGE2 was inhibited by treatment with essential oil from O. gratissimum.	Dinoprostone	43-47	interleukin 1 beta	Homo sapiens	13-21
27807462-5	2016	Baseline and IL-1beta-induced secretion of PGE2 was inhibited by treatment with essential oil from O. gratissimum.	Oils, Volatile	80-93	interleukin 1 beta	Homo sapiens	13-21
27807462-6	2016	Essential oils from B. pilosa and C. nardus had synergistic effects with IL-1beta on PGE2 seceretion.	Oils, Volatile	0-14	interleukin 1 beta	Homo sapiens	73-81
27807462-6	2016	Essential oils from B. pilosa and C. nardus had synergistic effects with IL-1beta on PGE2 seceretion.	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	73-81
26889257-2	2016	Catecholamines have been indicated to exert an enhancing effect on the IL-1beta release.	Catecholamines	0-14	interleukin 1 beta	Homo sapiens	71-79
26889257-3	2016	The aim of the present study was to determine whether alterations in inflammasome gene expression may be responsible for the modified IL-1beta and IL-18 secretion following lipopolysaccharide (LPS) and catecholamine co-stimulation.	Catecholamines	202-215	interleukin 1 beta	Homo sapiens	134-142
26889257-5	2016	Following stimulation with LPS (2 microg/ml) and/or phenylephrine (PE; 10 microM) for 24 h, the supernatants were subjected to ELISA to evaluate the ex vivo protein expression levels of IL-1beta and IL-18.	Phenylephrine	52-65	interleukin 1 beta	Homo sapiens	186-194
26586620-5	2016	We investigated this issue by monitoring the effects of polyozellin on phorbol-12-myristate 13-acetate (PMA)-, tumor necrosis factor (TNF)-alpha-, interleukin (IL)-1beta-induced EPCR shedding in human umbilical vein endothelial cells (HUVECs), and cecal ligation and puncture (CLP)-mediated EPCR shedding in mice and underlying mechanism.	polyozellin	56-67	interleukin 1 beta	Homo sapiens	147-169
26718326-5	2016	We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells).	Tetradecanoylphorbol Acetate	69-100	interleukin 1 beta	Homo sapiens	264-286
26718326-5	2016	We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells).	Calcium	106-113	interleukin 1 beta	Homo sapiens	264-286
28042296-6	2016	PCR analysis of 7 OA patient cartilages revealed that 10 muM DFO suppressed expression of MMP-1, MMP-13, IL-1beta, and TNFalpha and a marker of chondrocyte hypertrophy, COL10A1.	Deferoxamine	61-64	interleukin 1 beta	Homo sapiens	105-113
26836188-8	2016	The results showed that gx-50 is able to act as a specific ligand to activate alpha7 nAChR, which then upregulates the JAK2/STAT3 and PI3K/AKT signaling pathways to inhibit the secretions of pro-inflammatory cytokines, such as IL-1beta.	nachr	85-90	interleukin 1 beta	Homo sapiens	227-235
26423306-8	2016	PHE/TYR was positively correlated with interleukin (IL)-1beta (r = 0.37, p = 0.011) and IL-6 (r = 0.33, p = 0.025).	Phenylalanine	0-3	interleukin 1 beta	Homo sapiens	39-61
26423306-8	2016	PHE/TYR was positively correlated with interleukin (IL)-1beta (r = 0.37, p = 0.011) and IL-6 (r = 0.33, p = 0.025).	Tyrosine	4-7	interleukin 1 beta	Homo sapiens	39-61
26596264-9	2016	Furthermore, use of the CGRP (8-37), ERK inhibitor PD 98059, SQ 22536 or H-89 abolished the CGRP mediated increase in IL-1beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	51-59	interleukin 1 beta	Homo sapiens	118-126
27057094-3	2016	The results indicated that GEN-27 inhibited the proliferation of human colon tumor HCT116 cells stimulated by culture supernatants of LPS-induced human monocytes THP-1 cells and significantly decreased LPS-induced secretion of proinflammatory cytokines interleukin-6 and interleukin-1beta in THP-1 cells.	gen-27	27-33	interleukin 1 beta	Homo sapiens	271-288
27057094-6	2016	In addition, GEN-27 markedly suppressed the HCT116 cell proliferation stimulated by IL-1beta treatment, which was dependent on the inhibition of NF-kappaB/p65 nuclear localization, as verified by p65 overexpression and BAY 11-7082, an NF-kappaB inhibitor.	gen-27	13-19	interleukin 1 beta	Homo sapiens	84-92
27057094-6	2016	In addition, GEN-27 markedly suppressed the HCT116 cell proliferation stimulated by IL-1beta treatment, which was dependent on the inhibition of NF-kappaB/p65 nuclear localization, as verified by p65 overexpression and BAY 11-7082, an NF-kappaB inhibitor.	3-(4-methylphenylsulfonyl)-2-propenenitrile	219-230	interleukin 1 beta	Homo sapiens	84-92
28095390-9	2016	In addition, NaHS inhibited FSE-induced microglial responses and suppressed the production of IL-1beta and TNF-alpha in the hippocampus.	sodium bisulfide	13-17	interleukin 1 beta	Homo sapiens	94-102
26854669-6	2016	Covariance analysis confirmed that differences in IL-1beta and IL-6 levels were determined by pharmacotherapy and fasting plasma glucose, whereas in IL-10 levels by the therapy only.	Glucose	129-136	interleukin 1 beta	Homo sapiens	50-58
27994266-8	2016	In both RA and OA patient groups, stimulation of SAAT explants with IL-1beta (1 ng/ml/100 mg tissue) significantly up-regulated release of pro-(IL-6, IL-8, tumor necrosis factor - TNF) and anti-inflammatory (IL-10) cytokines but had no effect on the secretion of adiponectin, leptin, MIF and hepatocyte growth factor (HGF).	saat	49-53	interleukin 1 beta	Homo sapiens	68-76
26565141-4	2016	IL-1beta-treated disc organ cultures showed a statistically significant upregulation of proinflammatory markers (IL-6, IL-8, prostaglandin E2 [PGE2]) and metalloproteases (MMP1, MMP3) expression, while extracellular matrix (ECM) proteins (collagen II, aggrecan) were significantly downregulated.	Dinoprostone	125-141	interleukin 1 beta	Homo sapiens	0-8
26565141-4	2016	IL-1beta-treated disc organ cultures showed a statistically significant upregulation of proinflammatory markers (IL-6, IL-8, prostaglandin E2 [PGE2]) and metalloproteases (MMP1, MMP3) expression, while extracellular matrix (ECM) proteins (collagen II, aggrecan) were significantly downregulated.	Dinoprostone	143-147	interleukin 1 beta	Homo sapiens	0-8
26559977-0	2015	Interleukin-1beta Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin.	Calcium	47-54	interleukin 1 beta	Homo sapiens	0-17
26559977-9	2015	Using an ELISA-based protein-binding assay, the interaction of recombinant calmodulin with pro-IL-1beta, but not mature IL-1beta, was confirmed and shown to be calcium-dependent.	Calcium	160-167	interleukin 1 beta	Homo sapiens	91-103
26559977-9	2015	Using an ELISA-based protein-binding assay, the interaction of recombinant calmodulin with pro-IL-1beta, but not mature IL-1beta, was confirmed and shown to be calcium-dependent.	Calcium	160-167	interleukin 1 beta	Homo sapiens	95-103
26559977-10	2015	Finally, using small molecule inhibitors, it was demonstrated that both calcium and calmodulin were required for nigericin-induced IL-1beta secretion in THP-1 cells and primary human monocytes.	Nigericin	113-122	interleukin 1 beta	Homo sapiens	131-139
26559977-11	2015	Together, these data suggest that, following calcium influx into the cell, pro-IL-1beta interacts with calmodulin and that this interaction is important for IL-1beta processing and release.	Calcium	45-52	interleukin 1 beta	Homo sapiens	75-87
26559977-11	2015	Together, these data suggest that, following calcium influx into the cell, pro-IL-1beta interacts with calmodulin and that this interaction is important for IL-1beta processing and release.	Calcium	45-52	interleukin 1 beta	Homo sapiens	79-87
26689911-5	2015	Based on our preliminary findings we hypothesized that treatment of MMs with chemotherapeutic drugs may elevate the levels of NLRP3 and caspase-1 resulting in increased cell death by pyroptosis while increasing the levels of IL-1beta and other pro-inflammatory molecules.	Methyl Methanesulfonate	68-71	interleukin 1 beta	Homo sapiens	225-233
26546608-3	2015	In this study, we found that in activated macrophages artificial reduction of iATP by 2-deoxyglucose, a glycolysis inhibitor, caused mitochondrial membrane depolarization, leading to IL-1beta secretion via NLRP3 and caspase-1 activation.	Deoxyglucose	86-100	interleukin 1 beta	Homo sapiens	183-191
26546608-5	2015	These results demonstrate the fundamental roles of iATP in the maintenance of mitochondrial function and regulation of IL-1beta secretion, and they suggest that maintenance of the intracellular ATP pools could be a strategy for countering NLRP3-mediated inflammation.	Adenosine Triphosphate	52-55	interleukin 1 beta	Homo sapiens	119-127
27337797-5	2015	After treating the schizophrenics with the neuroleptic risperidone for 6 months, the serum levels of HMGB1, IL-1beta, TNF-alpha and IL-6 were decreased.	Risperidone	55-66	interleukin 1 beta	Homo sapiens	108-116
26588227-6	2015	On the other hand, the gene expression of pro-inflammatory cytokines TNF-alpha, IL-6, and IL-1beta was inhibited by PL supplementation.	pl	116-118	interleukin 1 beta	Homo sapiens	90-98
26592517-9	2015	Furthermore, treatment with Fe(2+) significantly increased the gene expression of IL-1beta, IL-6 and TNF-alpha, and induced the nuclear translocation of NF-kappaB.	ammonium ferrous sulfate	28-34	interleukin 1 beta	Homo sapiens	82-90
26580447-7	2015	Dietary TB supplementation inhibited the increase of interleukin-1beta (in the jejunum and ileum), interleukin-6 (in the duodenum and jejunum), and prostaglandin E2 (in the duodenum) of LPS-challenged broilers.	tributyrin	8-10	interleukin 1 beta	Homo sapiens	53-70
26403276-0	2015	The stellate vascular smooth muscle cell phenotype is induced by IL-1beta via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	65-73
26403276-5	2015	We then investigated the possible association of this IL-1beta-dependent change in morphology with an increase in intracellular cAMP concentration ([cAMP]), using the FRET-based biosensor for cAMP (T)Epac(VV).	Cyclic AMP	128-132	interleukin 1 beta	Homo sapiens	54-62
26403276-5	2015	We then investigated the possible association of this IL-1beta-dependent change in morphology with an increase in intracellular cAMP concentration ([cAMP]), using the FRET-based biosensor for cAMP (T)Epac(VV).	Cyclic AMP	149-153	interleukin 1 beta	Homo sapiens	54-62
26403276-5	2015	We then investigated the possible association of this IL-1beta-dependent change in morphology with an increase in intracellular cAMP concentration ([cAMP]), using the FRET-based biosensor for cAMP (T)Epac(VV).	Cyclic AMP	149-153	interleukin 1 beta	Homo sapiens	54-62
26403276-6	2015	Experiments in the presence of IL-1beta or medium conditioned by IL-1beta-treated VSMCs and pharmacological tools demonstrated that the long-term increase in intracellular cAMP concentration was induced by the secretion of an autocrine/paracrine mediator, prostaglandin E2(PGE2), acting through the EP4 receptor.	Cyclic AMP	172-176	interleukin 1 beta	Homo sapiens	31-39
26403276-6	2015	Experiments in the presence of IL-1beta or medium conditioned by IL-1beta-treated VSMCs and pharmacological tools demonstrated that the long-term increase in intracellular cAMP concentration was induced by the secretion of an autocrine/paracrine mediator, prostaglandin E2(PGE2), acting through the EP4 receptor.	Cyclic AMP	172-176	interleukin 1 beta	Homo sapiens	65-73
26403276-6	2015	Experiments in the presence of IL-1beta or medium conditioned by IL-1beta-treated VSMCs and pharmacological tools demonstrated that the long-term increase in intracellular cAMP concentration was induced by the secretion of an autocrine/paracrine mediator, prostaglandin E2(PGE2), acting through the EP4 receptor.	Dinoprostone	256-272	interleukin 1 beta	Homo sapiens	65-73
26403276-6	2015	Experiments in the presence of IL-1beta or medium conditioned by IL-1beta-treated VSMCs and pharmacological tools demonstrated that the long-term increase in intracellular cAMP concentration was induced by the secretion of an autocrine/paracrine mediator, prostaglandin E2(PGE2), acting through the EP4 receptor.	Dinoprostone	273-277	interleukin 1 beta	Homo sapiens	65-73
26258991-11	2015	Fenofibrate reduced IL-1beta induced production of each of these neutrophilic chemokines at the concentrations used.	Fenofibrate	0-11	interleukin 1 beta	Homo sapiens	20-28
26398903-5	2015	This work also found that PRRSV nonstructural protein (nsp) 11 could inhibit the expression of pro-IL-1beta mRNA induced by lipopolysaccharide (LPS) and the secretion of IL-1beta induced by LPS plus nigericin in PAMs.	Nigericin	199-208	interleukin 1 beta	Homo sapiens	170-178
26062798-2	2015	Here, the effects of ginsenoside Rb1 (GRb1) on the expression of MMP-13 in IL-1beta-induced SW 1353 chondrosarcoma cells and an experimental rat model of OA induced by anterior cruciate ligament transection (ACLT) were investigated.	Ginsenosides	21-32	interleukin 1 beta	Homo sapiens	75-83
26770183-5	2015	However, ENO1 stimulation increased the production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6, and these cytokines were downregulated by pretreatment with GV1001.	gv1001	218-224	interleukin 1 beta	Homo sapiens	124-146
26156811-0	2015	Thymoquinone Inhibits IL-1beta-Induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing NF-kappaB and MAPKs Signaling Pathway.	thymoquinone	0-12	interleukin 1 beta	Homo sapiens	22-30
26156811-2	2015	However, the anti-inflammatory effect of thymoquinone on IL-1beta-stimulated osteoarthritis chondrocytes remains unclear.	thymoquinone	41-53	interleukin 1 beta	Homo sapiens	57-65
26156811-3	2015	In this study, we designed to investigate the anti-inflammatory effects and elucidated the underlying mechanism of thymoquinone on IL-1beta-stimulated human osteoarthritis chondrocytes.	thymoquinone	115-127	interleukin 1 beta	Homo sapiens	131-139
26156811-5	2015	The results demonstrated that thymoquinone concentration-dependently inhibited IL-1beta-induced COX-2, iNOS, NO, and PGE2 production.	thymoquinone	30-42	interleukin 1 beta	Homo sapiens	79-87
26156811-5	2015	The results demonstrated that thymoquinone concentration-dependently inhibited IL-1beta-induced COX-2, iNOS, NO, and PGE2 production.	Dinoprostone	117-121	interleukin 1 beta	Homo sapiens	79-87
26156811-6	2015	Thymoquinone also suppressed IL-1beta-induced MMP-1, MMP3, and MMP13 production.	thymoquinone	0-12	interleukin 1 beta	Homo sapiens	29-37
26156811-7	2015	We found that thymoquinone significantly inhibited IL-1beta-induced NF-kappaB activation and IkappaBalpha degradation.	thymoquinone	14-26	interleukin 1 beta	Homo sapiens	51-59
26156811-8	2015	In addition, thymoquinone was found to suppress IL-1beta-induced mitogen-activated protein kinases (MAPKs) activation.	thymoquinone	13-25	interleukin 1 beta	Homo sapiens	48-56
26156811-9	2015	In conclusion, thymoquinone inhibited IL-1beta-induced inflammatory mediator production by inhibition of NF-kappaB and MAPKs signaling pathways in osteoarthritis chondrocytes.	thymoquinone	15-27	interleukin 1 beta	Homo sapiens	38-46
26156812-0	2015	Calcitriol Suppressed Inflammatory Reactions in IL-1beta-Stimulated Human Periodontal Ligament Cells.	Calcitriol	0-10	interleukin 1 beta	Homo sapiens	48-56
26156812-5	2015	Calcitriol inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 20, CXC chemokine ligand (CXCL) 10, and matrix metalloproteinase (MMP)-3 release from IL-1beta-stimulated HPDLC.	Calcitriol	0-10	interleukin 1 beta	Homo sapiens	159-167
26156812-7	2015	Moreover, we found c-jun N-terminal kinase (JNK) phosphorylation and IkappaB-alpha degradation in IL-1beta-stimulated HPDLC were inhibited by calcitriol, and JNK and nuclear factor (NF)-kappaB inhibitors could decrease IL-6, IL-8, CCL20, CXCL10, and MMP-3 productions in IL-1beta-treated HPDLC.	Calcitriol	142-152	interleukin 1 beta	Homo sapiens	98-106
26156812-7	2015	Moreover, we found c-jun N-terminal kinase (JNK) phosphorylation and IkappaB-alpha degradation in IL-1beta-stimulated HPDLC were inhibited by calcitriol, and JNK and nuclear factor (NF)-kappaB inhibitors could decrease IL-6, IL-8, CCL20, CXCL10, and MMP-3 productions in IL-1beta-treated HPDLC.	Calcitriol	142-152	interleukin 1 beta	Homo sapiens	271-279
26456836-11	2015	Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	170-178
26456836-11	2015	Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression.	Superoxides	24-40	interleukin 1 beta	Homo sapiens	170-178
26507163-6	2015	mRNA and protein expressions of IL-1beta and IL-8 decreased significantly when pretreated HCECs with recombinant human SP-D for 4h before A. fumigatus stimulation, while IL-1beta and IL-8 increased when pretreated with SP-D antibody for 1h.	Hydrogen	237-239	interleukin 1 beta	Homo sapiens	32-40
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	14-21	interleukin 1 beta	Homo sapiens	72-80
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	14-21	interleukin 1 beta	Homo sapiens	203-211
26590114-7	2015	Fisetin also inhibited the production of NO, PGE2 IL-1beta, IL-6, expression of iNOS and COX-2, and activation of NF-kappaB in HaCaT cells treated with TNF-alpha.	fisetin	0-7	interleukin 1 beta	Homo sapiens	50-58
26456498-6	2015	Besides, interleukin-1beta was positively correlated with isoprostanes.	Isoprostanes	58-70	interleukin 1 beta	Homo sapiens	9-26
26350254-7	2015	These results were supported by experiments in the human colonic epithelial cell line Caco-2, where ALA supplementation was shown to be effective in inhibiting inflammation induced by IL-1beta by down-regulating mRNA levels of pro-inflammatory genes including IL-8, COX2 and inducible nitric oxide synthase.	alpha-Linolenic Acid	100-103	interleukin 1 beta	Homo sapiens	184-192
26334245-9	2015	Pharmacologic and siRNA-mediated inhibition of PLD1 and PLD2 attenuated the nicotine- and LPS-induced upregulation of inducible nitric oxide (NO) synthase and cyclooxygenase-2, production of NO, and prostaglandin E2, and mRNA expression and secretion of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-8.	Nicotine	76-84	interleukin 1 beta	Homo sapiens	283-305
26452501-5	2015	PA also increased pro-inflammatory cytokines expression, including tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta).	Palmitates	0-2	interleukin 1 beta	Homo sapiens	134-151
26452501-5	2015	PA also increased pro-inflammatory cytokines expression, including tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta).	Palmitates	0-2	interleukin 1 beta	Homo sapiens	153-161
26769828-10	2015	Moreover, the TLR6, NO, iNOS, IL-1beta, MCP-1, and the keratinocyte chemoattractant (KC) levels significantly decreased in the zymosan-stimulated groups maintained in riboflavin-enriched medium.	Zymosan	127-134	interleukin 1 beta	Homo sapiens	30-38
26384528-2	2015	Hyperglycemia and hyperlipidemia in diabetics not only contribute to altered metabolism but glucose and free fatty acids can directly activate inflammation and the production of the proinflammatory cytokine interleukin 1beta (IL-1beta).	Glucose	92-99	interleukin 1 beta	Homo sapiens	207-224
26384528-2	2015	Hyperglycemia and hyperlipidemia in diabetics not only contribute to altered metabolism but glucose and free fatty acids can directly activate inflammation and the production of the proinflammatory cytokine interleukin 1beta (IL-1beta).	Glucose	92-99	interleukin 1 beta	Homo sapiens	226-234
26384528-2	2015	Hyperglycemia and hyperlipidemia in diabetics not only contribute to altered metabolism but glucose and free fatty acids can directly activate inflammation and the production of the proinflammatory cytokine interleukin 1beta (IL-1beta).	Fatty Acids, Nonesterified	104-120	interleukin 1 beta	Homo sapiens	207-224
26384528-2	2015	Hyperglycemia and hyperlipidemia in diabetics not only contribute to altered metabolism but glucose and free fatty acids can directly activate inflammation and the production of the proinflammatory cytokine interleukin 1beta (IL-1beta).	Fatty Acids, Nonesterified	104-120	interleukin 1 beta	Homo sapiens	226-234
26431797-5	2015	In this study, we have discovered that CPT-11 promotes macrophage infiltration into intestinal tissues and activates the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, resulting in a robust IL-1beta response and colonic inflammation similar to DSS (dextran sodium sulfate) induced experimental colitis.	Irinotecan	39-45	interleukin 1 beta	Homo sapiens	217-225
26431797-5	2015	In this study, we have discovered that CPT-11 promotes macrophage infiltration into intestinal tissues and activates the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, resulting in a robust IL-1beta response and colonic inflammation similar to DSS (dextran sodium sulfate) induced experimental colitis.	dss	271-274	interleukin 1 beta	Homo sapiens	217-225
26431797-5	2015	In this study, we have discovered that CPT-11 promotes macrophage infiltration into intestinal tissues and activates the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, resulting in a robust IL-1beta response and colonic inflammation similar to DSS (dextran sodium sulfate) induced experimental colitis.	dextran sodium sulfate	276-298	interleukin 1 beta	Homo sapiens	217-225
26462152-5	2015	In this study, we demonstrated that tyrosine phosphorylation of EGFR is crucial for the IL-1beta-mediated proliferation and subsequent bromodeoxyuridine (BrdU) incorporation of DOK cells because the EGFR inhibitors AG1478 and erlotinib inhibit these abilities in a dose-dependent manner.	Tyrosine	36-44	interleukin 1 beta	Homo sapiens	88-96
26462152-5	2015	In this study, we demonstrated that tyrosine phosphorylation of EGFR is crucial for the IL-1beta-mediated proliferation and subsequent bromodeoxyuridine (BrdU) incorporation of DOK cells because the EGFR inhibitors AG1478 and erlotinib inhibit these abilities in a dose-dependent manner.	RTKI cpd	215-221	interleukin 1 beta	Homo sapiens	88-96
26462152-5	2015	In this study, we demonstrated that tyrosine phosphorylation of EGFR is crucial for the IL-1beta-mediated proliferation and subsequent bromodeoxyuridine (BrdU) incorporation of DOK cells because the EGFR inhibitors AG1478 and erlotinib inhibit these abilities in a dose-dependent manner.	Erlotinib Hydrochloride	226-235	interleukin 1 beta	Homo sapiens	88-96
26462152-7	2015	Furthermore, tyrosine phosphorylation of EGFR was significantly enhanced in DOK (1 h) and OSCC (20 min) cell lines after IL-1beta treatment, and both cell lines were inhibited on the addition of an IL-1 receptor antagonist (IL-1Ra).	Tyrosine	13-21	interleukin 1 beta	Homo sapiens	121-129
26462152-8	2015	CXCL1 treatment resulted in EGFR phosphorylation, whereas the knockdown of CXCL1 expression by lentivirus-mediated shRNA or the addition of the CXCR2 antagonist SB225002 dramatically reduced IL-1beta-mediated EGFR phosphorylation and proliferation of DOK cells.	SB 225002	161-169	interleukin 1 beta	Homo sapiens	191-199
26462152-9	2015	Neutralizing antibodies against IL-1beta or CXCL1 markedly inhibited the constitutive or IL-1beta-induced tyrosine phosphorylation of EGFR in OSCC cells.	Tyrosine	106-114	interleukin 1 beta	Homo sapiens	32-40
26472707-5	2015	Results indicates that pretreatment with Cucurbitacins significantly reduced the pro-inflammatory cytokine (TNF-alpha, IL-1beta and IL-6) and attenuated iNOS and COX-2 expression in TLR 2/4 agonists-stimulated microglia.	Cucurbitacins	41-54	interleukin 1 beta	Homo sapiens	119-127
26884987-7	2015	Our results showed that beta-asarone attenuated inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 production.	asarone	24-36	interleukin 1 beta	Homo sapiens	122-139
26884987-7	2015	Our results showed that beta-asarone attenuated inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 production.	asarone	24-36	interleukin 1 beta	Homo sapiens	141-149
26567164-5	2015	RESULTS: Lower TB antigen-induced IL1beta (p = 0.006), TNFalpha (p = 0.02) and IL7 (p = 0.009) were produced in the poor outcome group.	Terbium	15-17	interleukin 1 beta	Homo sapiens	34-41
26562662-10	2015	The inhibitors for ERK1/2 (PD98059 and U0216) and a p38 MAPK (SB203580) significantly reduced the IL-1beta-induced IL-36gamma mRNA expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	27-34	interleukin 1 beta	Homo sapiens	98-106
26562662-10	2015	The inhibitors for ERK1/2 (PD98059 and U0216) and a p38 MAPK (SB203580) significantly reduced the IL-1beta-induced IL-36gamma mRNA expression.	SB 203580	62-70	interleukin 1 beta	Homo sapiens	98-106
26545369-5	2015	Pearson"s r correlation showed significance between the  IL-1beta and both the  CES-D score (r = 0.740, p &lt; 0.01) and the  KYN/TRP (kynurenine/tryptophan) ratio (r = 0.536, p = 0.02).	Kynurenine	126-129	interleukin 1 beta	Homo sapiens	57-65
26545369-5	2015	Pearson"s r correlation showed significance between the  IL-1beta and both the  CES-D score (r = 0.740, p &lt; 0.01) and the  KYN/TRP (kynurenine/tryptophan) ratio (r = 0.536, p = 0.02).	Tryptophan	130-133	interleukin 1 beta	Homo sapiens	57-65
26545369-5	2015	Pearson"s r correlation showed significance between the  IL-1beta and both the  CES-D score (r = 0.740, p &lt; 0.01) and the  KYN/TRP (kynurenine/tryptophan) ratio (r = 0.536, p = 0.02).	Kynurenine	135-145	interleukin 1 beta	Homo sapiens	57-65
26545369-5	2015	Pearson"s r correlation showed significance between the  IL-1beta and both the  CES-D score (r = 0.740, p &lt; 0.01) and the  KYN/TRP (kynurenine/tryptophan) ratio (r = 0.536, p = 0.02).	Tryptophan	146-156	interleukin 1 beta	Homo sapiens	57-65
26545369-7	2015	Mediation analysis showed that the relationship between the  KYN/TRP ratio and the  CES-D score was mediated by the  IL-1beta.	Tryptophan	65-68	interleukin 1 beta	Homo sapiens	117-125
26335060-4	2015	The pretreatment of microglia with the inducible NO synthase inhibitor 1400W prior to LPS stimulation significantly reduced the production of IL-1beta, and the addition of the NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP) into microglia led to the induction of IL-1beta.	snap	185-220	interleukin 1 beta	Homo sapiens	267-275
26216444-6	2015	N(1)-MeSpd diminished intracellular reactive oxygen species production in cultured keratinocytes, and reduced tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 gene and protein expression after lipopolysaccharide stimulation.	4-(2-(4-isopropylbenzamido)ethoxy)benzoic acid	0-4	interleukin 1 beta	Homo sapiens	139-161
25847254-3	2015	We found that 10-MDP caused the release of inflammatory cytokines including NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and IL-8 in a concentration-dependent manner.	methacryloyloxydecyl dihydrogen phosphate	14-20	interleukin 1 beta	Homo sapiens	110-118
26381871-10	2015	1,25(OH)2D3 decreased intracellular free cholesterol and polarized macrophages to M2 phenotype with decreased expression of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 under lipopolysaccharide stimulation.	Calcitriol	0-11	interleukin 1 beta	Homo sapiens	153-170
26327597-12	2015	LDL(-) triggered 2-fold caspase-1 activation compared to native LDL and IL-1beta release was strongly diminished in the presence of the caspase-1 inhibitor Z-YVAD.	z-yvad	156-162	interleukin 1 beta	Homo sapiens	72-80
26366788-7	2015	The up-regulated DEGs, such as epidermal growth factor (EGF) and interleukin 1 beta (IL-1beta) were significantly enriched in KEGG pathways of focal adhesion, ECM-receptor interaction and calcium signaling pathway.	Calcium	188-195	interleukin 1 beta	Homo sapiens	65-83
26366788-7	2015	The up-regulated DEGs, such as epidermal growth factor (EGF) and interleukin 1 beta (IL-1beta) were significantly enriched in KEGG pathways of focal adhesion, ECM-receptor interaction and calcium signaling pathway.	Calcium	188-195	interleukin 1 beta	Homo sapiens	85-93
26209886-4	2015	The PBMC treatment with PHA plus nicotine produced a significant decrease of IL-1beta e IL-17 both as transcript and as protein, confirming that the PBMC of the patients respond to the cholinergic stimulation more than PBMC of HD.	Nicotine	33-41	interleukin 1 beta	Homo sapiens	77-85
26172313-6	2015	NO-np significantly suppressed IL-1beta, tumor necrosis factor-alpha (TNF-alpha), IL-8, and IL-6 from human monocytes, and IL-8 and IL-6 from human keratinocytes, respectively.	Neptunium	3-5	interleukin 1 beta	Homo sapiens	31-39
26083549-5	2015	Expression of key inflammasome components (NOD2, NLRP3, and caspase 1) along with caspase-cleaved interleukins IL-1beta and IL-33 could be induced by priming with lipopolysaccharide and activation with muramyl dipeptide.	Acetylmuramyl-Alanyl-Isoglutamine	202-219	interleukin 1 beta	Homo sapiens	111-119
26083549-6	2015	In addition, combined treatment with lipopolysaccharide and muramyl dipeptide resulted in IL-1beta secretion in a caspase- and ERK1/2 kinase-dependent manner.	Acetylmuramyl-Alanyl-Isoglutamine	60-77	interleukin 1 beta	Homo sapiens	90-98
26156202-6	2015	Moreover, a significant positive correlation between serum IL-1beta level and glucose (p1 = 0.044) was showed.	Glucose	78-85	interleukin 1 beta	Homo sapiens	59-67
26220057-5	2015	The sequential drug release of LDC and THD from the developed LDC-THD-GO nanosheets exhibited a synergistic effect on neuropathic pain in vitro and in vivo, as evidenced by the increased pain threshold in mechanical allodynia and hyperalgesic response tests, and the improved inhibition of proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and nitric oxide.	Thalidomide	39-42	interleukin 1 beta	Homo sapiens	327-335
26283733-3	2015	Concomitant with increased inflammation-related gene expression (interleukin-1beta [IL-1beta]), the mRNA levels of the above PCs are significantly increased, together with those of the proteinase-activated receptor 1 (PAR1), an inflammation-associated receptor that is cleaved by thrombin at ProArg41  (where the down arrow indicates the cleavage location), and potentially by PCs at Arg41XXXXArg46 .	arg41xxxxarg46	384-398	interleukin 1 beta	Homo sapiens	65-82
26283733-3	2015	Concomitant with increased inflammation-related gene expression (interleukin-1beta [IL-1beta]), the mRNA levels of the above PCs are significantly increased, together with those of the proteinase-activated receptor 1 (PAR1), an inflammation-associated receptor that is cleaved by thrombin at ProArg41  (where the down arrow indicates the cleavage location), and potentially by PCs at Arg41XXXXArg46 .	arg41xxxxarg46	384-398	interleukin 1 beta	Homo sapiens	84-92
26521743-11	2015	Expression of NOX4/p22(phox) as well as ROS production is enhanced by IL-1beta.	Reactive Oxygen Species	40-43	interleukin 1 beta	Homo sapiens	70-78
26216515-7	2015	This occurs via IL-1beta-primed secretion of PGE2 and activates T-cell intrinsic regulatory mechanisms (SOCS2, GADD45A).	Dinoprostone	45-49	interleukin 1 beta	Homo sapiens	16-24
26352276-6	2015	ELISA demonstrated that pitavastatin inhibited mRNA and protein expression of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha.	pitavastatin	24-36	interleukin 1 beta	Homo sapiens	78-100
27226903-5	2016	Significant involvement of pro-inflammatory cytokines-including interleukin (IL)-1beta, IL-6 and tumour necrosis factor-alpha-exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes.	dienes	259-265	interleukin 1 beta	Homo sapiens	64-86
26363456-5	2015	HG and IL-1beta decrease MCT4 and its location on plasma membrane, as well as increase lactic acid accumulation and apoptosis in HUVECs.	Lactic Acid	87-98	interleukin 1 beta	Homo sapiens	7-15
26875270-12	2015	ELISA results showed that IL-1beta and TNF-alpha in supernatants of Pgenesil-1/HMGB1 siRNA group were significantly lower than those of Pgenesil-1 group and untransfected group (P &lt; 0.05).	pgenesil-1	68-78	interleukin 1 beta	Homo sapiens	26-34
26099791-9	2015	Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60.	Hydroxyethyl Starch Derivatives	13-16	interleukin 1 beta	Homo sapiens	175-183
26522350-6	2015	RESULTS: Polydatin significantly improved the viability of cells with OGD/R treatment, and apparently inhibited the secretion of TNF-alpha and IL-1beta induced by OGD/R.	polydatin	9-18	interleukin 1 beta	Homo sapiens	143-151
26213325-3	2015	The EndoC-betaH1 cells died rapidly when exposed to IL-1beta + IFN-gamma, and this occurred also in the presence of the actinomycin D.	Dactinomycin	120-133	interleukin 1 beta	Homo sapiens	52-60
26502906-4	2016	The treatment of cells with a chemical inhibitor of glycosphingolipid biosynthesis, which suppresses the expression of the Stx receptor globotriaosylceramide and subsequent endocytosis of the toxin, substantially blocked activation of the NLRP3 inflammasome and processing of caspase-1 and IL-1beta.	Glycosphingolipids	52-69	interleukin 1 beta	Homo sapiens	290-298
26502906-8	2016	Taken together, these results suggest that Stxs trigger the NLRP3 inflammasome pathway to release proinflammatory IL-1beta as well as to promote apoptotic cell death.	Saxitoxin	43-47	interleukin 1 beta	Homo sapiens	114-122
26407655-4	2015	Pre-treatment of loganin reduced pancreatic damage and AP-associated lung injury and attenuated the severity of AP, as evidenced by (1) a reduction in several biochemical parameters (pancreatic weight to body weight ratio, myeloperoxidase activity, and level of amylase) and (2) production of pro-inflammatory cytokines such as interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	loganin	17-24	interleukin 1 beta	Homo sapiens	328-350
26407655-5	2015	However, post-treatment of loganin failed to improve pancreatic damage and biochemical parameters of AP, but could inhibit the AP-induced elevation of IL-1beta and TNF-alpha significantly.	loganin	27-34	interleukin 1 beta	Homo sapiens	151-159
26875270-12	2015	ELISA results showed that IL-1beta and TNF-alpha in supernatants of Pgenesil-1/HMGB1 siRNA group were significantly lower than those of Pgenesil-1 group and untransfected group (P &lt; 0.05).	pgenesil	68-76	interleukin 1 beta	Homo sapiens	26-34
26500455-8	2015	Treatment with a combination of IL-6, LPS, TNF-alpha, IFN- gamma and IL-1beta induced the highest nitrite secretion (2.91 fold, P &lt; 0.01) as compared to cells incubated in medium alone.	Nitrites	98-105	interleukin 1 beta	Homo sapiens	69-77
26306596-4	2015	Nitric oxide production, which is markedly elevated in pancreatic beta-cells exposed to IL-1beta, is a negative regulator of both glucose-stimulated insulin secretion and glucose-induced increases in intracellular calcium levels.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	88-96
26306596-4	2015	Nitric oxide production, which is markedly elevated in pancreatic beta-cells exposed to IL-1beta, is a negative regulator of both glucose-stimulated insulin secretion and glucose-induced increases in intracellular calcium levels.	Glucose	130-137	interleukin 1 beta	Homo sapiens	88-96
26306596-4	2015	Nitric oxide production, which is markedly elevated in pancreatic beta-cells exposed to IL-1beta, is a negative regulator of both glucose-stimulated insulin secretion and glucose-induced increases in intracellular calcium levels.	Glucose	171-178	interleukin 1 beta	Homo sapiens	88-96
26306596-4	2015	Nitric oxide production, which is markedly elevated in pancreatic beta-cells exposed to IL-1beta, is a negative regulator of both glucose-stimulated insulin secretion and glucose-induced increases in intracellular calcium levels.	Calcium	214-221	interleukin 1 beta	Homo sapiens	88-96
26306596-5	2015	By contrast, the IL-1beta-mediated production of the chemokines CCL2 and CCL20 was not influenced by either nitric oxide levels or glucose concentration.	Nitric Oxide	108-120	interleukin 1 beta	Homo sapiens	17-25
26193055-4	2015	Erdosteine significantly suppressed the production of reactive nitrogen/oxygen species and pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in cisplatin-treated cells.	Cisplatin	191-200	interleukin 1 beta	Homo sapiens	155-177
26468333-8	2015	The expression of TLR4, MyD88 and IL-1beta was enhanced by high glucose in cultured HMEC-1 and the expression of TLR4 and IL-1beta was inhibited by TLR4 siRNA knock-down and TLR4 antagonist.	Glucose	64-71	interleukin 1 beta	Homo sapiens	34-42
26468083-7	2015	RESULTS: We found that Everolimus significantly inhibited the differentiation of OCs and their in vitro bone-resorbing activity, and also found decreases of both mRNA and secreted pro-OC factors such as M-CSF, IL-6, and IL-1beta, whose lower ELISA levels paralleled the defective phosphorylation of NFkB pathway effectors.	Everolimus	23-33	interleukin 1 beta	Homo sapiens	220-228
26468333-8	2015	The expression of TLR4, MyD88 and IL-1beta was enhanced by high glucose in cultured HMEC-1 and the expression of TLR4 and IL-1beta was inhibited by TLR4 siRNA knock-down and TLR4 antagonist.	Glucose	64-71	interleukin 1 beta	Homo sapiens	122-130
25958167-7	2015	Bates-Jensen wound assessment tool severity scorings, proinflammatory cytokines (tumor necrosis factor-alpha, interleukin 1beta, and interleukin 6), and matrix metalloproteinase-8 were significantly decreased in response to CTI.	titanium carbide	224-227	interleukin 1 beta	Homo sapiens	110-127
26446923-9	2015	In comparison to the explants treated only with LPS, pre-treatment with 0.01-1.0 muM progesterone significantly blunted (73, 56, 56, 75, 25, 48 %) the secretion of TNF-alpha, IL-1beta, IL-6, IL-8, MIP-1alpha, IL-10, respectively.	Progesterone	85-97	interleukin 1 beta	Homo sapiens	175-183
25108419-3	2015	The aim of this study was to evaluate the in vitro effect of polyacrylic acid (PAA)-coated ION and non-coated ION on the production of six cytokines [interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), interleukin 8 (IL-8), interferon gamma (IFN-gamma) and interleukin 10 (IL-10)] by human peripheral blood cells, and to determine the inflammatory pathways involved in this production.	carbopol 940	61-77	interleukin 1 beta	Homo sapiens	150-168
25108419-3	2015	The aim of this study was to evaluate the in vitro effect of polyacrylic acid (PAA)-coated ION and non-coated ION on the production of six cytokines [interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), interleukin 8 (IL-8), interferon gamma (IFN-gamma) and interleukin 10 (IL-10)] by human peripheral blood cells, and to determine the inflammatory pathways involved in this production.	carbopol 940	79-82	interleukin 1 beta	Homo sapiens	150-168
26174085-5	2015	In addition to caspase-4, efficient IL-1beta conversion upon intracellular LPS delivery relies on potassium efflux, NLRP3, ASC, and caspase-1, indicating that although caspase-4 activation alone is sufficient to induce pyroptosis, this process depends on the NLRP3 inflammasome activation to drive IL-1beta maturation.	Potassium	98-107	interleukin 1 beta	Homo sapiens	36-44
26195551-4	2015	Our previous study showed that PGA activates the human macrophage cell line THP-1 and human dendritic cells, resulting in the production of the proinflammatory cytokine interleukin-1beta (IL-1beta) (M. H. Cho et al., Infect Immun 78:387-392, 2010, http://dx.doi.org/10.1128/IAI.00956-09).	Folic Acid	31-34	interleukin 1 beta	Homo sapiens	169-186
26195551-4	2015	Our previous study showed that PGA activates the human macrophage cell line THP-1 and human dendritic cells, resulting in the production of the proinflammatory cytokine interleukin-1beta (IL-1beta) (M. H. Cho et al., Infect Immun 78:387-392, 2010, http://dx.doi.org/10.1128/IAI.00956-09).	Folic Acid	31-34	interleukin 1 beta	Homo sapiens	188-196
26143263-8	2015	Moreover, PGD2-MS stimulated the production of nitric oxide, TNF-alpha, IL-1beta, and TGF-beta, more than free PGD2, indicating that microencapsulation increased the activating effect of PGD2 on cells.	Prostaglandin D2	10-14	interleukin 1 beta	Homo sapiens	72-80
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 1 beta	Homo sapiens	83-100
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 1 beta	Homo sapiens	102-110
26162701-0	2015	Anti-inflammatory effects of farrerol on IL-1beta-stimulated human osteoarthritis chondrocytes.	farrerol	29-37	interleukin 1 beta	Homo sapiens	41-49
26162701-1	2015	The present study aimed to investigate the anti-inflammatory effects and the underlying molecular mechanism of farrerol on IL-1beta-stimulated human osteoarthritis chondrocytes.	farrerol	111-119	interleukin 1 beta	Homo sapiens	123-131
26162701-5	2015	The results showed that farrerol remarkably inhibited IL-1beta-induced NO and PGE2 production, as well as COX-2 and iNOS expression.	farrerol	24-32	interleukin 1 beta	Homo sapiens	54-62
26162701-5	2015	The results showed that farrerol remarkably inhibited IL-1beta-induced NO and PGE2 production, as well as COX-2 and iNOS expression.	Dinoprostone	78-82	interleukin 1 beta	Homo sapiens	54-62
26162701-6	2015	Farrerol also inhibited IL-1beta-induced NF-kappaB activation.	farrerol	0-8	interleukin 1 beta	Homo sapiens	24-32
26162701-7	2015	Furthermore, farrerol significantly inhibited IL-1beta-induced phosphorylation of PI3K and Akt.	farrerol	13-21	interleukin 1 beta	Homo sapiens	46-54
26162701-8	2015	In conclusion, these results indicated that farrerol inhibited IL-1beta-induced inflammatory responses in osteoarthritis chondrocytes by blocking PI3K/Akt/NF-kappaB signaling pathway.	farrerol	44-52	interleukin 1 beta	Homo sapiens	63-71
26740893-15	2015	Levocetirizine has a better effect on decreasing the symptoms and plasmatic levels of IL-1beta and IL-8.	levocetirizine	0-14	interleukin 1 beta	Homo sapiens	86-94
26095630-3	2015	In this paper, we evaluated the production of IL-1 beta and TNF, in peripheral blood MO of patients affected by RA or T2D or both diseases, in order to understand if an alteration of the glucose metabolism may influence their proinflammatory status.	Glucose	187-194	interleukin 1 beta	Homo sapiens	46-55
26095630-4	2015	Our data showed, after 24 h of incubation with different glucose concentrations, a significantly increased production of IL-1beta and TNF in all evaluated groups when compared with healthy controls.	Glucose	57-64	interleukin 1 beta	Homo sapiens	121-129
26183082-7	2015	However, systemic administration of DIONPs resulted in enhanced proliferation of mitogen-stimulated spleen derived lymphocytes and secretion of IL-1beta at day 7 post exposure.	dionps	36-42	interleukin 1 beta	Homo sapiens	144-152
25750008-11	2015	Compared with the control group, the hydrogen group had a statistically significantly lower expression of IL-1beta (P = 0.0317), IL-6 (P = 0.0159), IL-8 (P = 0.0195) and TNF-alpha (P = 0.0159).	Hydrogen	37-45	interleukin 1 beta	Homo sapiens	106-114
26116704-4	2015	Moreover, the caspase 1 inhibitor Z-YVAD-FMK and the cathepsin B inhibitor CA-074Me reduced production of IL-1beta in a dose-dependent manner after LPS + MSU treatment.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	34-44	interleukin 1 beta	Homo sapiens	106-114
26116704-4	2015	Moreover, the caspase 1 inhibitor Z-YVAD-FMK and the cathepsin B inhibitor CA-074Me reduced production of IL-1beta in a dose-dependent manner after LPS + MSU treatment.	CA 074 methyl ester	75-83	interleukin 1 beta	Homo sapiens	106-114
26226011-7	2015	Finally, homozygosity for the ATG16L1 risk variant and low SHIP mRNA expression is inversely related to increased (LPS+ATP)-induced IL-1beta production by PBMCs in our cohorts and was regulated by increased transcription of ILIB.	Adenosine Triphosphate	119-122	interleukin 1 beta	Homo sapiens	132-140
26722449-11	2015	Under high glucose environment, hRECs proliferation increased, TNF-alpha and IL-1beta expression elevated, and NF-kappaB protein level upregulated significantly.	Glucose	11-18	interleukin 1 beta	Homo sapiens	77-85
26722449-13	2015	Pterostilbene can suppress hRECs over proliferation, decrease TNF-alpha and IL-1beta, inhibit NF-kappaB protein expression, reduce ROS production, and increase SOD activity markedly compared with high glucose group (P &lt; 0.05).	pterostilbene	0-13	interleukin 1 beta	Homo sapiens	76-84
26133961-8	2015	For the overall inflammatory response, IL-6, TNF-alpha, MIP-1alpha, MIP-1beta, and inflammatory protein (IP)-10 were significantly suppressed and IL-8, IL-10, and IL-1beta significantly increased following exposure to PC-SNs in the presence of LPS.	pc-sns	218-224	interleukin 1 beta	Homo sapiens	163-171
25504009-1	2015	The main objective of the study was to evaluate whether in vitro QuantiFERON-TB Gold In-Tube (QFT-GIT) assay antigen-specific IL-1beta, TNF-alpha, IL-2, IL-6, IL-8 and IL-12 (p40) production is associated with active TB.	Terbium	77-79	interleukin 1 beta	Homo sapiens	126-134
25504009-9	2015	Our results suggest that antigen-specific IL-1beta can be used as a biomarker for active TB diagnosis as well as for differential diagnosis of PTB and LTBI.	Terbium	89-91	interleukin 1 beta	Homo sapiens	42-50
26238426-0	2015	Peroxisome proliferator-activated receptor gamma prevents the production of NOD-like receptor family, pyrin domain containing 3 inflammasome and interleukin 1beta in HK-2 renal tubular epithelial cells stimulated by monosodium urate crystals.	Uric Acid	216-232	interleukin 1 beta	Homo sapiens	145-162
26002427-5	2015	Since there are no studies in the literature reporting the inflammatory profile of MSUD patients and the L-car role on the inflammatory response in this disorder, the present study evaluates the effect of L-car supplementation on plasma inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon-gamma (INF-gamma), and a correlation with malondialdehyde (MDA), as a marker of oxidative damage, and with free L-car plasma levels in treated MSUD patients.	Carnitine	205-210	interleukin 1 beta	Homo sapiens	260-277
26168875-4	2015	In this study, we investigated whether IL-1beta affects the GABA-evoked currents (I(GABA)) in TLE tissue from humans.	gamma-Aminobutyric Acid	60-64	interleukin 1 beta	Homo sapiens	39-47
26252250-7	2015	The results of the present study demonstrated that resveratrol inhibited the proliferation of oAbeta-induced microglia and the production of pro-inflammatory factors, including ROS, NO, TNF-alpha and IL-1beta.	Resveratrol	51-62	interleukin 1 beta	Homo sapiens	200-208
26168875-4	2015	In this study, we investigated whether IL-1beta affects the GABA-evoked currents (I(GABA)) in TLE tissue from humans.	gamma-Aminobutyric Acid	84-88	interleukin 1 beta	Homo sapiens	39-47
26168875-6	2015	We report the novel finding that pathophysiological concentrations of IL-1beta decreased the I(GABA) amplitude by up to 30% in specimens from patients with TLE with or without HS, but not in control tissues.	gamma-Aminobutyric Acid	95-99	interleukin 1 beta	Homo sapiens	70-78
26168875-6	2015	We report the novel finding that pathophysiological concentrations of IL-1beta decreased the I(GABA) amplitude by up to 30% in specimens from patients with TLE with or without HS, but not in control tissues.	hassio	176-178	interleukin 1 beta	Homo sapiens	70-78
26168875-10	2015	Our findings suggest a novel mechanism possibly underlying the ictogenic action of IL-1beta, thus suggesting that this cytokine contributes to seizure generation in human TLE by reducing GABA-mediated neurotransmission.	gamma-Aminobutyric Acid	187-191	interleukin 1 beta	Homo sapiens	83-91
26212544-2	2015	In this study, we investigated the possible modulation by levornidazole of NOD-like receptor protein 3 (NLRP3) inflammasome-mediated IL-1beta and IL-18 release from macrophages.	Ornidazole Levo-	58-71	interleukin 1 beta	Homo sapiens	133-141
26758116-9	2015	(2) IL-1 beta, IL-4, IL-6, IL-8, IL-10, IFN-gamma in BALF of steroid group and non steroid group were both significantly higher than that of control group.	Steroids	61-68	interleukin 1 beta	Homo sapiens	4-13
26758116-11	2015	(3) In steroid group, IL-2 and IL-8 in BALF of patient whose fever disappeared after steroid therapy were both significantly lower than that of patients who still had fever (t=2.771, 2.054, P=0.010, 0.049) , but no significant difference was found between the two groups in BALF IL-1 beta, IL-4, IL-6, IL-10, IFN-gamma levels (P&gt;0.05).	Steroids	7-14	interleukin 1 beta	Homo sapiens	279-288
26758116-13	2015	(2) Incresed BALF IL-1 beta, IL-4, IL-6, IL-8, IL-10, IFN-gamma levels were observed in RMPP and high level of BALF IL-2 and IL-8 might have some relevance with persistent fever of RMPP in children.	rmpp	88-92	interleukin 1 beta	Homo sapiens	18-27
26467114-5	2015	The supernatants of resting and IL-1beta-stimulated Caco2, HT-29 and SW-1116 colonic epithelial cells (CEC), cell lysates of CECs and tear samples of human healthy individuals were analyzed and the feasibility of the developed method was validated by ELISA and dot-blot analysis complemented by RT-qPCR.	caco2	52-57	interleukin 1 beta	Homo sapiens	32-40
27551463-9	2015	SAG overexpression stimulated protumorigenic cytokines, IL-1beta, IL-6 and TNF, but not antitumorigenic IL-12p40 and anti-inflammatory IL-10.	sagopilone	0-3	interleukin 1 beta	Homo sapiens	56-64
26385789-6	2015	NLRP3 function (IL-1beta secretion) was assessed upon priming of TLR2 (Pam(3)CysSK(4), TLR3 (poly(I:C)) or TLR4 (LPS) and ATP sequential treatment.	Adenosine Triphosphate	122-125	interleukin 1 beta	Homo sapiens	16-24
26385789-11	2015	Secreted IL-1beta in culture supernatants from whole blood cells activated with TLR4 (LPS) or TLR3 agonist (poly(I:C)) plus ATP was higher in RA patients (n = 20) versus controls (n = 18) (p &lt; 0.02 for both).	Adenosine Triphosphate	124-127	interleukin 1 beta	Homo sapiens	9-17
26212544-4	2015	Surprisingly, an in vitro study showed that levornidazole suppressed IL-1beta and IL-18 secretion by blocking the activation of the NLRP3 inflammasome.	Ornidazole Levo-	44-57	interleukin 1 beta	Homo sapiens	69-77
25986659-9	2015	Cinacalcet also elevated expression of the proinflammatory factors IL1beta, IL6 and CCL2.	Cinacalcet	0-10	interleukin 1 beta	Homo sapiens	67-74
26277062-0	2015	Glucose stimulates chondrocyte differentiation of vascular smooth muscle cells and calcification: A possible role for IL-1beta.	Glucose	0-7	interleukin 1 beta	Homo sapiens	118-126
26277062-4	2015	These effects were associated with increased expression of IL-1beta, which stimulated alkaline phosphatase and calcification, suggesting that glucose induces chondrocyte differentiation of VSMCs, possibly through IL-1beta activation.	Glucose	142-149	interleukin 1 beta	Homo sapiens	59-67
26277062-4	2015	These effects were associated with increased expression of IL-1beta, which stimulated alkaline phosphatase and calcification, suggesting that glucose induces chondrocyte differentiation of VSMCs, possibly through IL-1beta activation.	Glucose	142-149	interleukin 1 beta	Homo sapiens	213-221
26355342-10	2015	In contrast, the LPS challenge is blocked by the ER stress inhibitor TUDCA, resulting in: CHOP downregulation, reduced caspase-1, caspase-11, caspase-3 activities, lowered interleukin-1beta secretion and rescue from cell death.	ursodoxicoltaurine	69-74	interleukin 1 beta	Homo sapiens	172-189
25962664-0	2015	Hydrogen gas production is associated with reduced interleukin-1beta mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients.	Hydrogen	0-8	interleukin 1 beta	Homo sapiens	51-68
25962664-0	2015	Hydrogen gas production is associated with reduced interleukin-1beta mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients.	Acarbose	117-125	interleukin 1 beta	Homo sapiens	51-68
25962664-8	2015	However, the changes in total hydrogen gas production from day 1 to day 2 were closely and inversely associated with the changes in peripheral blood IL-1beta mRNA levels.	Hydrogen	30-38	interleukin 1 beta	Homo sapiens	149-157
25962664-9	2015	Our results suggest that an increase in hydrogen gas production is inversely associated with a reduction of the peripheral blood IL-1beta mRNA level after a single dose of acarbose in Japanese type 2 diabetic patients.	Hydrogen	40-48	interleukin 1 beta	Homo sapiens	129-137
25962664-9	2015	Our results suggest that an increase in hydrogen gas production is inversely associated with a reduction of the peripheral blood IL-1beta mRNA level after a single dose of acarbose in Japanese type 2 diabetic patients.	Acarbose	172-180	interleukin 1 beta	Homo sapiens	129-137
26007645-2	2015	In this study, the opioid antagonist beta-funaltrexamine (beta-FNA) decreases the expression and release of an inflammatory chemokine, interferon-gamma inducible protein-10 (CXCL10) from normal human astrocytes stimulated by interleukin 1beta (IL-1beta).	beta-funaltrexamine	37-56	interleukin 1 beta	Homo sapiens	225-242
26007645-2	2015	In this study, the opioid antagonist beta-funaltrexamine (beta-FNA) decreases the expression and release of an inflammatory chemokine, interferon-gamma inducible protein-10 (CXCL10) from normal human astrocytes stimulated by interleukin 1beta (IL-1beta).	beta-funaltrexamine	37-56	interleukin 1 beta	Homo sapiens	244-252
26007645-2	2015	In this study, the opioid antagonist beta-funaltrexamine (beta-FNA) decreases the expression and release of an inflammatory chemokine, interferon-gamma inducible protein-10 (CXCL10) from normal human astrocytes stimulated by interleukin 1beta (IL-1beta).	beta-funaltrexamine	58-66	interleukin 1 beta	Homo sapiens	225-242
26007645-2	2015	In this study, the opioid antagonist beta-funaltrexamine (beta-FNA) decreases the expression and release of an inflammatory chemokine, interferon-gamma inducible protein-10 (CXCL10) from normal human astrocytes stimulated by interleukin 1beta (IL-1beta).	beta-funaltrexamine	58-66	interleukin 1 beta	Homo sapiens	244-252
26007645-5	2015	IL-1beta-induced activation of p38 mitogen-activated protein kinases (p38 MAPK) was inhibited by beta-FNA as shown by decreased p38 MAPK phosphorylation in treated cells.	beta-funaltrexamine	97-105	interleukin 1 beta	Homo sapiens	0-8
26007645-8	2015	IL-1beta upregulated the expression of A20, a ubiquitin (Ub)-editing enzyme that dampens NF-kappaB signaling by altering ubiquination patterns on IL-1 receptor second messengers, and the increase in A20 was significantly inhibited by beta-FNA treatment.	beta-funaltrexamine	234-242	interleukin 1 beta	Homo sapiens	0-8
26333527-7	2015	IL-6, IL-8, IL-1beta and TNF-alpha concentration in NBL showed inverse correlation coefficients with the peroxidation products of fatty acids.	Fatty Acids	130-141	interleukin 1 beta	Homo sapiens	12-20
25894228-6	2015	Here, we investigated if APS attenuates IL-1beta- or TNF-alpha-mediated IL-6 and IL-8 expression in SZ95 sebocytes, whereas TNF-alpha was used as control.	aps	25-28	interleukin 1 beta	Homo sapiens	40-49
26219195-0	2015	Effects of curcumin on crevicular levels of IL-1beta and CCL28 in experimental gingivitis.	Curcumin	11-19	interleukin 1 beta	Homo sapiens	44-52
25894228-11	2015	Concomitant treatment of SZ95 sebocytes with APS attenuated the effect of IL-1beta and TNF-alpha on IL-6 and IL-8 gene expression as well as on IL-1beta-mediated NF-kappaB signaling.	aps	45-48	interleukin 1 beta	Homo sapiens	74-82
25894228-11	2015	Concomitant treatment of SZ95 sebocytes with APS attenuated the effect of IL-1beta and TNF-alpha on IL-6 and IL-8 gene expression as well as on IL-1beta-mediated NF-kappaB signaling.	aps	45-48	interleukin 1 beta	Homo sapiens	144-152
26219195-2	2015	The aim of this study was to compare interleukin-1beta (IL-1beta) and chemokine (C-C motif) ligand 28 (CCL28) levels following a topical application of curcumin (CRM), chlorhexidine (CHX) and chlorhexidine-metronidazole (CHX-MTZ) in an experimental gingivitis human model.	Curcumin	152-160	interleukin 1 beta	Homo sapiens	56-64
26219195-7	2015	RESULTS: The increase of IL-1beta in the CRM (14.52 +- 16.6 pg/ml) and CHX-MTZ (31.63 +- 15.96) groups was significantly less than that of the CHX group (70.55 +- 38.81).	chx-mtz	71-78	interleukin 1 beta	Homo sapiens	25-33
26219195-10	2015	CONCLUSIONS: The anti-inflammatory potential of topical curcumin was similar to CHX-MTZ but superior to CHX in affecting IL-1beta and CCL28 levels.	Curcumin	56-64	interleukin 1 beta	Homo sapiens	121-129
26140661-4	2015	KEY RESULTS: In dHUVEC treated with IL-1beta, the expression of COX-2 mRNA and protein was enhanced and generation of prostanoids increased (the most abundant was the promitogenic PGF2alpha ).	dhuvec	16-22	interleukin 1 beta	Homo sapiens	36-44
25774043-6	2015	Lower levels of proinflammatory cytokine (IL-6, TNF-alpha, IFN-gamma, and IL-1beta) transcripts were detected in ileum of FeDex-treated piglets, which indicated that iron supplementation could attenuate the increase of inflammatory cytokines caused by iron deficiency.	Iron	166-170	interleukin 1 beta	Homo sapiens	74-82
26307448-4	2015	A 4-h priming of peritoneal macrophages with LPS followed by a 30-min incubation with ATP caused the activation of caspase 1 and the release of IL-1beta, indicative of inflammasome activation.	Adenosine Triphosphate	86-89	interleukin 1 beta	Homo sapiens	144-152
26307448-6	2015	(-)Sch B suppressed the LPS/ATP-induced activation of caspase 1 and release of IL-1beta in peritoneal macrophages.	Adenosine Triphosphate	28-31	interleukin 1 beta	Homo sapiens	79-87
26140661-4	2015	KEY RESULTS: In dHUVEC treated with IL-1beta, the expression of COX-2 mRNA and protein was enhanced and generation of prostanoids increased (the most abundant was the promitogenic PGF2alpha ).	Prostaglandins	118-129	interleukin 1 beta	Homo sapiens	36-44
26140661-4	2015	KEY RESULTS: In dHUVEC treated with IL-1beta, the expression of COX-2 mRNA and protein was enhanced and generation of prostanoids increased (the most abundant was the promitogenic PGF2alpha ).	Dinoprost	180-189	interleukin 1 beta	Homo sapiens	36-44
26140661-6	2015	dHUVEC showed increased proliferation in response to IL-1beta, which was prevented by a COX-2 inhibitor and PGF2alpha receptor antagonist.	dhuvec	0-6	interleukin 1 beta	Homo sapiens	53-61
26140661-7	2015	Comparable changes in COX-2 mRNA, miR-16 and c-Myc detected in dHUVEC were produced in nHUVEC exposed to transient high glucose and then stimulated with IL-1beta under physiological glucose levels; superoxide anion production was enhanced under these experimental conditions.	dhuvec	63-69	interleukin 1 beta	Homo sapiens	153-161
26140661-7	2015	Comparable changes in COX-2 mRNA, miR-16 and c-Myc detected in dHUVEC were produced in nHUVEC exposed to transient high glucose and then stimulated with IL-1beta under physiological glucose levels; superoxide anion production was enhanced under these experimental conditions.	Glucose	182-189	interleukin 1 beta	Homo sapiens	153-161
25934648-6	2015	RESULTS: IL-1beta stimuli increased SLe(x) and alpha2,6-sialic acid levels in MDAPanc-28 cells and enhanced the mRNA levels of ST3GAL3-4 and FUT5-7, which codify for ST and FucT enzymes related to SLe(x) biosynthesis, and of ST6GAL1.	alpha2,6-sialic acid	47-67	interleukin 1 beta	Homo sapiens	9-17
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	genipin	13-20	interleukin 1 beta	Homo sapiens	97-115
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	genipin	13-20	interleukin 1 beta	Homo sapiens	117-125
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	Adenosine Triphosphate	29-51	interleukin 1 beta	Homo sapiens	97-115
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	Adenosine Triphosphate	29-51	interleukin 1 beta	Homo sapiens	117-125
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	Adenosine Triphosphate	53-56	interleukin 1 beta	Homo sapiens	97-115
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	Adenosine Triphosphate	53-56	interleukin 1 beta	Homo sapiens	117-125
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	Hydrogen Peroxide	63-80	interleukin 1 beta	Homo sapiens	97-115
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	Hydrogen Peroxide	63-80	interleukin 1 beta	Homo sapiens	117-125
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	Hydrogen Peroxide	82-86	interleukin 1 beta	Homo sapiens	97-115
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	Hydrogen Peroxide	82-86	interleukin 1 beta	Homo sapiens	117-125
26123077-8	2015	Taken together, our results suggest that genipin modulates NLRP3 inflammasome activation and ATP- or H2O2-mediated IL-1beta release.	Adenosine Triphosphate	93-96	interleukin 1 beta	Homo sapiens	115-123
26123077-8	2015	Taken together, our results suggest that genipin modulates NLRP3 inflammasome activation and ATP- or H2O2-mediated IL-1beta release.	Hydrogen Peroxide	101-105	interleukin 1 beta	Homo sapiens	115-123
26093270-2	2015	Results revealed that capsaicin inhibits LPS-induced IL-1beta, IL-6 and TNF-alpha production in a time- and dose-dependent manner.	Capsaicin	22-31	interleukin 1 beta	Homo sapiens	53-61
26138240-8	2015	IL-1beta-pre-treated RSFs challenged by SF for 72 h showed 234.41 +- 17.6 muM/ml increase (patient 3, grade 3), whereas higher NO after LPS pre-treatment was recorded (118.92 +- 6.2 muM/ml; patient 3, grade 3).	rsfs	21-25	interleukin 1 beta	Homo sapiens	0-8
26235941-4	2015	Pretreatment of the cells with TNF-alpha and/or IL-1beta enhanced Ca(2+) response in a time- and concentration-dependent additive manner, whereas the potency of BK and that of the selective B2 receptor antagonist, fasitibant chloride, both in the nanomolar range, remained unaffected.	(4-amino-5-(4-(4-(2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido)tetrahydro-2H-4-pyranoylcarbonyl)piperazino)-5-oxopentyl)(trimethyl)ammonium	214-233	interleukin 1 beta	Homo sapiens	48-56
26093270-4	2015	Inhibition of LXRalpha activation by siRNA diminished the inhibitory action of capsaicin on LPS-induced IL-1beta, IL-6 and TNF-alpha production.	Capsaicin	79-88	interleukin 1 beta	Homo sapiens	104-112
26292179-5	2015	The presence of IL-1beta determined a significant increase (P&lt;0.001) in PGE2 levels measured by an ELISA assay, and in COX-2 and MMP-3, -9, and -13 gene expression analyzed by RT-PCR.	Dinoprostone	75-79	interleukin 1 beta	Homo sapiens	16-24
26096886-9	2015	These effects were accompanied by a decreased intracellular activation of caspase-1 and interleukin-1beta release from ATP-treated cells, thus suggesting that FAEs antagonise the effects of ATP by preventing the activation of the pyroptotic molecular cascade leading to cell death.	Adenosine Triphosphate	119-122	interleukin 1 beta	Homo sapiens	88-105
26096886-9	2015	These effects were accompanied by a decreased intracellular activation of caspase-1 and interleukin-1beta release from ATP-treated cells, thus suggesting that FAEs antagonise the effects of ATP by preventing the activation of the pyroptotic molecular cascade leading to cell death.	Fumarates	159-163	interleukin 1 beta	Homo sapiens	88-105
26096886-9	2015	These effects were accompanied by a decreased intracellular activation of caspase-1 and interleukin-1beta release from ATP-treated cells, thus suggesting that FAEs antagonise the effects of ATP by preventing the activation of the pyroptotic molecular cascade leading to cell death.	Adenosine Triphosphate	190-193	interleukin 1 beta	Homo sapiens	88-105
26292179-6	2015	VA694, Naproxcinod and Naproxen, at both concentrations analyzed, significantly counteracted the negative effects induced by IL-1beta.	VA 694	0-5	interleukin 1 beta	Homo sapiens	125-133
26292179-6	2015	VA694, Naproxcinod and Naproxen, at both concentrations analyzed, significantly counteracted the negative effects induced by IL-1beta.	naproxen-n-butyl nitrate	7-18	interleukin 1 beta	Homo sapiens	125-133
26292179-6	2015	VA694, Naproxcinod and Naproxen, at both concentrations analyzed, significantly counteracted the negative effects induced by IL-1beta.	Naproxen	23-31	interleukin 1 beta	Homo sapiens	125-133
26292179-7	2015	VA694, Naproxcinod and Naproxen pre-treatment were able to inhibit IL-1beta-induced NF-kappaB activation, when measured as its nuclear translocation (p50 and p65 subunits).	VA 694	0-5	interleukin 1 beta	Homo sapiens	67-75
26292179-7	2015	VA694, Naproxcinod and Naproxen pre-treatment were able to inhibit IL-1beta-induced NF-kappaB activation, when measured as its nuclear translocation (p50 and p65 subunits).	naproxen-n-butyl nitrate	7-18	interleukin 1 beta	Homo sapiens	67-75
26292179-7	2015	VA694, Naproxcinod and Naproxen pre-treatment were able to inhibit IL-1beta-induced NF-kappaB activation, when measured as its nuclear translocation (p50 and p65 subunits).	Naproxen	23-31	interleukin 1 beta	Homo sapiens	67-75
26526225-10	2015	We found that 17beta-estradiol treatment at pharmacological dose significantly increases mRNA expression of CGRP in both groups (P&lt;0.001), whereas at physiological dose it could significantly decrease CGRP mRNA expression (P&lt;0.001), CGRP protein levels, IL-1beta release, NO production and iNOS activity only in patient groups (P&lt;0.05).	Estradiol	14-30	interleukin 1 beta	Homo sapiens	260-268
26526225-11	2015	CONCLUSION: Collectively, it appears that 17beta-estradiol can exert protective effect on decrease of inflammation in migraine via decrease in levels of CGRP, IL-1beta and iNOS activity; however, more studies are necessary in this regard.	Estradiol	42-58	interleukin 1 beta	Homo sapiens	159-167
25876063-5	2015	Osthole was able to suppress the levels of proinflammatory cytokines interleukin (IL)-1beta and IL-6, as well as chemokines monocyte chemoattractant protein-1 and IL-8.	osthol	0-7	interleukin 1 beta	Homo sapiens	69-91
26202987-0	2015	Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1beta Release.	Phosphorylcholine	0-14	interleukin 1 beta	Homo sapiens	92-100
26202987-0	2015	Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1beta Release.	Adenosine Triphosphate	80-83	interleukin 1 beta	Homo sapiens	92-100
26202987-4	2015	LPS from Gram-negative bacteria is a prototypical first signal inducing pro-IL-1beta synthesis, whereas extracellular ATP is a typical second signal sensed by the ATP receptor P2X7 that triggers activation of the NLRP3-containing inflammasome, proteolytic cleavage of pro-IL-1beta by caspase-1, and release of mature IL-1beta.	Adenosine Triphosphate	118-121	interleukin 1 beta	Homo sapiens	268-280
26202987-6	2015	In this article, we show that acetylcholine, choline, phosphocholine, phosphocholine-modified LPS from Haemophilus influenzae, and phosphocholine-modified protein efficiently inhibit ATP-mediated IL-1beta release in human and rat monocytes via nicotinic acetylcholine receptors containing subunits alpha7, alpha9, and/or alpha10.	Acetylcholine	30-43	interleukin 1 beta	Homo sapiens	196-204
26716206-6	2015	The productions of inflammatory cytokines, such as, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha were increased by IFN-gamma plus LPS but down-regulated by ZO-NP treatment.	zo-np	172-177	interleukin 1 beta	Homo sapiens	52-74
26202987-6	2015	In this article, we show that acetylcholine, choline, phosphocholine, phosphocholine-modified LPS from Haemophilus influenzae, and phosphocholine-modified protein efficiently inhibit ATP-mediated IL-1beta release in human and rat monocytes via nicotinic acetylcholine receptors containing subunits alpha7, alpha9, and/or alpha10.	Choline	36-43	interleukin 1 beta	Homo sapiens	196-204
26202987-6	2015	In this article, we show that acetylcholine, choline, phosphocholine, phosphocholine-modified LPS from Haemophilus influenzae, and phosphocholine-modified protein efficiently inhibit ATP-mediated IL-1beta release in human and rat monocytes via nicotinic acetylcholine receptors containing subunits alpha7, alpha9, and/or alpha10.	Phosphorylcholine	54-68	interleukin 1 beta	Homo sapiens	196-204
26202987-6	2015	In this article, we show that acetylcholine, choline, phosphocholine, phosphocholine-modified LPS from Haemophilus influenzae, and phosphocholine-modified protein efficiently inhibit ATP-mediated IL-1beta release in human and rat monocytes via nicotinic acetylcholine receptors containing subunits alpha7, alpha9, and/or alpha10.	Phosphorylcholine	70-84	interleukin 1 beta	Homo sapiens	196-204
26202987-6	2015	In this article, we show that acetylcholine, choline, phosphocholine, phosphocholine-modified LPS from Haemophilus influenzae, and phosphocholine-modified protein efficiently inhibit ATP-mediated IL-1beta release in human and rat monocytes via nicotinic acetylcholine receptors containing subunits alpha7, alpha9, and/or alpha10.	Adenosine Triphosphate	183-186	interleukin 1 beta	Homo sapiens	196-204
26202987-8	2015	Our data suggest that an endogenous anti-inflammatory cholinergic control mechanism effectively controls ATP-mediated release of IL-1beta and that the same mechanism is used by symbionts and misused by parasites to evade innate immune responses of the host.	Adenosine Triphosphate	105-108	interleukin 1 beta	Homo sapiens	129-137
26049028-4	2015	PF significantly down-regulated the production of interleukin (IL)-1beta and IL-6 from pSS PBMCs, and significantly inhibited ATP-induced expression of P2X7R, that might contribute to reduced IL-1beta and IL-6.	Adenosine Triphosphate	126-129	interleukin 1 beta	Homo sapiens	192-200
26049028-7	2015	Supernatant IL-1beta and IL-6 levels were significantly lower in the PF group compared with ATP group (p&lt;0.001, p&lt;0.001).	peoniflorin	69-71	interleukin 1 beta	Homo sapiens	12-20
26049028-8	2015	We show for the first time that PF-mediated reduction of IL-1beta and IL-6 was due in part to the reduced expression and activation of the ATP sensor P2X7R on pSS PBMCs, indicating that PF might be useful for the management of pSS via down-regulating P2X7R expression.	peoniflorin	32-34	interleukin 1 beta	Homo sapiens	57-65
26049028-8	2015	We show for the first time that PF-mediated reduction of IL-1beta and IL-6 was due in part to the reduced expression and activation of the ATP sensor P2X7R on pSS PBMCs, indicating that PF might be useful for the management of pSS via down-regulating P2X7R expression.	Adenosine Triphosphate	139-142	interleukin 1 beta	Homo sapiens	57-65
26049028-8	2015	We show for the first time that PF-mediated reduction of IL-1beta and IL-6 was due in part to the reduced expression and activation of the ATP sensor P2X7R on pSS PBMCs, indicating that PF might be useful for the management of pSS via down-regulating P2X7R expression.	pss	159-162	interleukin 1 beta	Homo sapiens	57-65
26049028-8	2015	We show for the first time that PF-mediated reduction of IL-1beta and IL-6 was due in part to the reduced expression and activation of the ATP sensor P2X7R on pSS PBMCs, indicating that PF might be useful for the management of pSS via down-regulating P2X7R expression.	pss	227-230	interleukin 1 beta	Homo sapiens	57-65
25529330-0	2015	Arecoline increases basic fibroblast growth factor but reduces expression of IL-1, IL-6, G-CSF and GM-CSF in human umbilical vein endothelium.	Arecoline	0-9	interleukin 1 beta	Homo sapiens	77-81
26716206-7	2015	Furthermore, the up-regulations of IL-1beta and TNF-alpha mRNAs by IFN-gamma plus LPS were reduced by ZO-NP at low (0.1 mug/mL) and high (10 mug/mL) concentrations.	zo-np	102-107	interleukin 1 beta	Homo sapiens	35-43
25987541-8	2015	RESULTS: With IL-1beta stimulation, IL-6 and PGE2 release was greater in human DM than non-DM OA cartilage (2.7- and 3-fold, respectively) (P &lt; 0.05).	Dinoprostone	45-49	interleukin 1 beta	Homo sapiens	14-22
26007240-5	2015	METHODS: The antiinflammation and antiproliferative activities of Di-cis-Py+ photoactivated was measured by myeloperoxidase (MPO) and N-acetyl-beta-d-glucosaminidase (NAG) enzyme activity assay, measurement of IL-6, IL-1beta and TNF-alpha levels, evaluation of proliferating cell nuclear antigen (PCNA) levels by immunohistochemistry and by Western blot.	di-cis-py+	66-76	interleukin 1 beta	Homo sapiens	216-224
26391839-0	2015	Antiinflammatory and antioxidant effects of H2O2 generated by natural sources in Il1beta-treated human endothelial cells.	Hydrogen Peroxide	44-48	interleukin 1 beta	Homo sapiens	81-88
26391839-3	2015	The results obtained showed that exogenously-generated H2O2 induce anti-inflammatory and antioxidant effects in HUVECs counteracting the pro-inflammatory and pro-oxidant effect of IL-1beta related to the production of superoxide anions.	Hydrogen Peroxide	55-59	interleukin 1 beta	Homo sapiens	180-188
26391839-3	2015	The results obtained showed that exogenously-generated H2O2 induce anti-inflammatory and antioxidant effects in HUVECs counteracting the pro-inflammatory and pro-oxidant effect of IL-1beta related to the production of superoxide anions.	Superoxides	218-235	interleukin 1 beta	Homo sapiens	180-188
26330510-9	2015	The effect of DMPA was exacerbated by lower levels of IL-1RA in gonorrhea, chlamydia, or herpes, SLPI in gonorrhea, and IL-1beta, MIP-3alpha, and IL-1RA/IL1beta ratio in trichomoniasis.	Medroxyprogesterone Acetate	14-18	interleukin 1 beta	Homo sapiens	120-128
26330510-9	2015	The effect of DMPA was exacerbated by lower levels of IL-1RA in gonorrhea, chlamydia, or herpes, SLPI in gonorrhea, and IL-1beta, MIP-3alpha, and IL-1RA/IL1beta ratio in trichomoniasis.	Medroxyprogesterone Acetate	14-18	interleukin 1 beta	Homo sapiens	153-160
25971793-5	2015	Parthenolide, Akt inhibitor, Bay 11-7085, and N-acetylcysteine each attenuated the lipopolysaccharide-induced production of IL-1beta and PGE2, increase in the levels of cyclooxygenase, formation of reactive oxygen species, increase in the levels of Toll-like receptor-4, and activation of the Akt/mTOR and NF-kappaB in keratinocytes.	parthenolide	0-12	interleukin 1 beta	Homo sapiens	124-132
25971793-5	2015	Parthenolide, Akt inhibitor, Bay 11-7085, and N-acetylcysteine each attenuated the lipopolysaccharide-induced production of IL-1beta and PGE2, increase in the levels of cyclooxygenase, formation of reactive oxygen species, increase in the levels of Toll-like receptor-4, and activation of the Akt/mTOR and NF-kappaB in keratinocytes.	BAY 11-7085	29-40	interleukin 1 beta	Homo sapiens	124-132
25971793-5	2015	Parthenolide, Akt inhibitor, Bay 11-7085, and N-acetylcysteine each attenuated the lipopolysaccharide-induced production of IL-1beta and PGE2, increase in the levels of cyclooxygenase, formation of reactive oxygen species, increase in the levels of Toll-like receptor-4, and activation of the Akt/mTOR and NF-kappaB in keratinocytes.	Acetylcysteine	46-62	interleukin 1 beta	Homo sapiens	124-132
25971793-5	2015	Parthenolide, Akt inhibitor, Bay 11-7085, and N-acetylcysteine each attenuated the lipopolysaccharide-induced production of IL-1beta and PGE2, increase in the levels of cyclooxygenase, formation of reactive oxygen species, increase in the levels of Toll-like receptor-4, and activation of the Akt/mTOR and NF-kappaB in keratinocytes.	Reactive Oxygen Species	198-221	interleukin 1 beta	Homo sapiens	124-132
25987541-10	2015	IL-1beta-increased IL-6 release was reduced with cytochalasin B, epalrestat, L-NAME or MitoTEMPO treatment (-45%, -62%, -38% and -40%, respectively).	Cytochalasin B	49-63	interleukin 1 beta	Homo sapiens	0-8
25987541-10	2015	IL-1beta-increased IL-6 release was reduced with cytochalasin B, epalrestat, L-NAME or MitoTEMPO treatment (-45%, -62%, -38% and -40%, respectively).	NG-Nitroarginine Methyl Ester	77-83	interleukin 1 beta	Homo sapiens	0-8
25987541-10	2015	IL-1beta-increased IL-6 release was reduced with cytochalasin B, epalrestat, L-NAME or MitoTEMPO treatment (-45%, -62%, -38% and -40%, respectively).	MitoTEMPO	87-96	interleukin 1 beta	Homo sapiens	0-8
25987541-12	2015	Accordingly, high glucose enhanced IL-1beta-induced inflammation in cultured chondrocytes via oxidative stress and the polyol pathway.	Glucose	18-25	interleukin 1 beta	Homo sapiens	35-43
25956731-6	2015	The equipotent P2Y2R agonists ATP and UTP enhanced proliferation, RAGE expression and HMGB1 secretion in IL-1beta-pretreated VSMCs.	Adenosine Triphosphate	30-33	interleukin 1 beta	Homo sapiens	105-113
25956731-6	2015	The equipotent P2Y2R agonists ATP and UTP enhanced proliferation, RAGE expression and HMGB1 secretion in IL-1beta-pretreated VSMCs.	Uridine Triphosphate	38-41	interleukin 1 beta	Homo sapiens	105-113
25956731-6	2015	The equipotent P2Y2R agonists ATP and UTP enhanced proliferation, RAGE expression and HMGB1 secretion in IL-1beta-pretreated VSMCs.	vsmcs	125-130	interleukin 1 beta	Homo sapiens	105-113
25956731-7	2015	Additionally, pretreatment with IL-1beta enhanced UTP-mediated VSMC migration and MMP-2 release, but these effects were not observed in the P2Y2R-siRNA- or RAGE-siRNA-transfected VSMCs.	Uridine Triphosphate	50-53	interleukin 1 beta	Homo sapiens	32-40
25956731-9	2015	The ERK, AKT, PKC, Rac-1 and ROCK2 pathways were involved in UTP-induced cell proliferation and migration, MMP-2 and HMGB1 secretion and RAGE expression in the IL-1beta-pretreated VSMCs.	Uridine Triphosphate	61-64	interleukin 1 beta	Homo sapiens	160-168
25956731-9	2015	The ERK, AKT, PKC, Rac-1 and ROCK2 pathways were involved in UTP-induced cell proliferation and migration, MMP-2 and HMGB1 secretion and RAGE expression in the IL-1beta-pretreated VSMCs.	vsmcs	180-185	interleukin 1 beta	Homo sapiens	160-168
25956731-10	2015	UTP induced the phosphorylation of ERK, AKT and PKC and the translocation of Rac-1 and ROCK2 from cytosol to membrane as well as stress fiber formation, which were markedly increased in the IL-1beta-pretreated VSMCs but not in the P2Y2R-siRNA-transfected VSMCs.	Uridine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	190-198
26234731-6	2015	However, only catechin inhibited MSU-induced IL-1beta secretion and NLRP3 inflammasome activation in MSU-challenged THP-1 cells.	Catechin	14-22	interleukin 1 beta	Homo sapiens	45-53
26317859-13	2015	RESULTS: Results demonstrate that macrophages exposed to H2O2 and ATP in the presence of resolvins show decreased IL-1beta production and activity.	Hydrogen Peroxide	57-61	interleukin 1 beta	Homo sapiens	114-122
26317859-13	2015	RESULTS: Results demonstrate that macrophages exposed to H2O2 and ATP in the presence of resolvins show decreased IL-1beta production and activity.	Adenosine Triphosphate	66-69	interleukin 1 beta	Homo sapiens	114-122
26041434-6	2015	An early burst of expression of IL-1beta is essential for suppression of the homeobox transcription factor Gax and related cyclin-dependent kinase inhibitor p21(Cip1), which are key regulators for cells exiting from cell cycle.	1-{3-[(4-Pyridin-2-Ylpiperazin-1-Yl)sulfonyl]phenyl}-3-(1,3-Thiazol-2-Yl)urea	107-110	interleukin 1 beta	Homo sapiens	32-40
26048654-7	2015	Exposure to triclosan increased the expression of TSLP, IL-1beta, and TNF-alpha in the skin with concomitant decreases in IL-25, IL-33, and IL-1alpha.	Triclosan	12-21	interleukin 1 beta	Homo sapiens	56-64
26234731-9	2015	These results indicate that the protective effects of catechin on MSU-induced IL-1beta secretion are associated with modulation of mitochondrial damage.	Catechin	54-62	interleukin 1 beta	Homo sapiens	78-86
26082493-5	2015	Here, we reported that in response to interleukin 1beta, the p65 subunit of NF-kappaB is phosphorylated on the novel serine 316.	Serine	117-123	interleukin 1 beta	Homo sapiens	38-55
26304941-2	2015	Colchicine is believed to block the NLRP3 inflammasome, a cytosolic complex responsible for the production of IL-1beta and IL-18.	Colchicine	0-10	interleukin 1 beta	Homo sapiens	110-118
26304941-10	2015	Colchicine administration significantly reduced transcoronary gradients of all 3 cytokines in ACS patients by 40% to 88% (P=0.028, 0.032, and 0.032, for IL-1beta, IL-18, and IL-6, respectively).	Colchicine	0-10	interleukin 1 beta	Homo sapiens	153-161
25967348-7	2015	Consistent with histology results, EGCG treatment significantly inhibited MCD diet-induced IL-1beta, IL-6, TNF-alpha and MCP-1 mRNA expression.	epigallocatechin gallate	35-39	interleukin 1 beta	Homo sapiens	91-99
26345937-7	2015	This inhibition was concentration-dependent between 0.3 and 3 muM, with 3 muM concentration of midazolam decreasing the IL-1beta-induced release of IL-6 by 43.58%.	Midazolam	95-104	interleukin 1 beta	Homo sapiens	120-128
26269716-6	2015	We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy.	Platinum	107-115	interleukin 1 beta	Homo sapiens	31-35
26152715-0	2015	Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1beta (IL-1beta) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.	Metformin	0-9	interleukin 1 beta	Homo sapiens	119-136
26152715-0	2015	Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1beta (IL-1beta) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.	Metformin	0-9	interleukin 1 beta	Homo sapiens	138-146
26152715-0	2015	Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1beta (IL-1beta) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.	Reactive Oxygen Species	37-60	interleukin 1 beta	Homo sapiens	119-136
26152715-0	2015	Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1beta (IL-1beta) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.	Reactive Oxygen Species	37-60	interleukin 1 beta	Homo sapiens	138-146
26152715-0	2015	Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1beta (IL-1beta) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.	NAD	66-70	interleukin 1 beta	Homo sapiens	119-136
26152715-0	2015	Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1beta (IL-1beta) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.	NAD	66-70	interleukin 1 beta	Homo sapiens	138-146
26152715-1	2015	Metformin, a frontline treatment for type II diabetes mellitus, decreases production of the pro-form of the inflammatory cytokine IL-1beta in response to LPS in macrophages.	Metformin	0-9	interleukin 1 beta	Homo sapiens	130-138
26152715-7	2015	Another complex I inhibitor, rotenone, mimicked the effect of metformin on pro-IL-1beta and IL-10.	Rotenone	29-37	interleukin 1 beta	Homo sapiens	79-87
26152715-7	2015	Another complex I inhibitor, rotenone, mimicked the effect of metformin on pro-IL-1beta and IL-10.	Metformin	62-71	interleukin 1 beta	Homo sapiens	79-87
26152715-9	2015	MitoQ, a mitochondrially targeted antioxidant, decreased LPS-induced IL-1beta without affecting TNF-alpha.	mitoquinone	0-5	interleukin 1 beta	Homo sapiens	69-77
26269716-6	2015	We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy.	taxane	187-193	interleukin 1 beta	Homo sapiens	31-35
26269716-6	2015	We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy.	Platinum	194-202	interleukin 1 beta	Homo sapiens	31-35
25904179-10	2015	When exposed to IL-1beta, poly:IC or IL-17, patient and control primary human keratinocytes produced AMPs in similar amounts.	adenosine 5'-phosphorothioate	101-105	interleukin 1 beta	Homo sapiens	16-24
26102024-0	2015	Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress.	ros	72-75	interleukin 1 beta	Homo sapiens	32-40
26102024-0	2015	Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress.	Glucose	126-133	interleukin 1 beta	Homo sapiens	32-40
26102024-5	2015	3-methyladenine (3-MA) inhibited occurrence of autophagy and it leaded to the accumulation of damaged-mitochondria-producing-ROS, and the activation of NLRP3 inflammasome, and subsequently, caused IL-1beta secretion.	3-methyladenine	0-15	interleukin 1 beta	Homo sapiens	197-205
26102024-5	2015	3-methyladenine (3-MA) inhibited occurrence of autophagy and it leaded to the accumulation of damaged-mitochondria-producing-ROS, and the activation of NLRP3 inflammasome, and subsequently, caused IL-1beta secretion.	3-methyladenine	17-21	interleukin 1 beta	Homo sapiens	197-205
26267804-4	2015	We showed that decrease in either UCH-L5 activity, or in UCH-L5 protein amount in chicken and human macrophages infected or stimulated with LPS/nigericin, led to decreased IL-1beta release.	Nigericin	144-153	interleukin 1 beta	Homo sapiens	172-180
26349982-4	2015	Mechanistic studies revealed that BDMC-A might have exerted its activity by inhibiting metastatic and angiogenic pathways by modulating the expression of proteins upstream to NF-kappaB (TGF-beta, TNF-alpha, IL-1beta and c-Src), and NF-kappaB signaling cascade (c-Rel, COX-2, MMP-9, VEGF, IL-8) and by upregulating TIMP-2 levels.	BDMC-A	34-40	interleukin 1 beta	Homo sapiens	207-215
26134749-6	2015	IL-1beta can activate eosinophils, which can release major basic protein (MBP) to antagonize the M2 receptors leading to excessive acetylcholine release.	Acetylcholine	131-144	interleukin 1 beta	Homo sapiens	0-8
25865800-4	2015	Activation of human MoDC resulted in the release of TNFalpha and IL-1beta that in turn stimulated MMP-1 (human collagenase) and PGE2 secretion by human dermal fibroblasts.	Dinoprostone	128-132	interleukin 1 beta	Homo sapiens	65-73
26093886-8	2015	Only in diabetic plaques, calcium content was inversely correlated with MCP1 and IL1b, whereas the direct correlation with TNF-alpha expression seen in non-diabetic plaques was lost in diabetes.	Calcium	26-33	interleukin 1 beta	Homo sapiens	81-85
25575547-6	2015	AAP (0.5-1.0 mM) and NAC (0.5-1.0 mM) used individually or in combination could down-regulate protein expression of cleaved caspase-1 and mRNA expression of IL-1beta, IL-18 and NLRP3.	Acetaminophen	0-3	interleukin 1 beta	Homo sapiens	157-165
25575547-6	2015	AAP (0.5-1.0 mM) and NAC (0.5-1.0 mM) used individually or in combination could down-regulate protein expression of cleaved caspase-1 and mRNA expression of IL-1beta, IL-18 and NLRP3.	Acetylcysteine	21-24	interleukin 1 beta	Homo sapiens	157-165
26231702-9	2015	RESULTS: The cell culture studies revealed that esomeprazole controls inflammation by suppressing the expression of pro-inflammatory molecules including vascular cell adhesion molecule-1, inducible nitric oxide synthase, tumor necrosis factor-alpha (TNF-alpha) and interleukins (IL-1beta and IL-6).	Esomeprazole	48-60	interleukin 1 beta	Homo sapiens	279-287
25382723-5	2015	This study shows that TBT modifies the secretion of IL-1beta from increasingly reconstituted preparations of human immune cells.	tributyltin	22-25	interleukin 1 beta	Homo sapiens	52-60
25382723-6	2015	IL-1beta secretion was examined after 24-, 48-h or 6-day exposures to TBT in highly enriched human natural killer (NK) cells, monocyte-depleted peripheral blood mononuclear cells (MD-PBMCs), PBMCs, granulocytes and a preparation combining both PBMCs and granulocytes (PBMCs+granulocytes).	tributyltin	70-73	interleukin 1 beta	Homo sapiens	0-8
25382723-7	2015	TBT altered IL-1beta secretion from all of the cell preparations.	tributyltin	0-3	interleukin 1 beta	Homo sapiens	12-20
25382723-8	2015	The 200 nM concentration of TBT normally blocked the secretion of IL-1beta, whereas lower concentrations (usually 5-50 nM) elevated secretion of IL-1beta.	tributyltin	28-31	interleukin 1 beta	Homo sapiens	66-74
25382723-11	2015	Results indicated that MAPK pathways (p44/42 and p38) appear to be the targets of TBT that lead to increased IL-1beta secretion from immune cells.	tributyltin	82-85	interleukin 1 beta	Homo sapiens	109-117
25382723-12	2015	These results from human immune cells show IL-1beta dysregulation by TBT is occurring ex vivo.	tributyltin	69-72	interleukin 1 beta	Homo sapiens	43-51
25856795-6	2015	We found that acacetin inhibits p38 and JNK phosphorylation and reduces MMP-1, MMP-3 and MMP-13 expression in interleukin-1beta-induced FLSs.	acacetin	14-22	interleukin 1 beta	Homo sapiens	110-127
25858687-7	2015	Moreover, co-treatment with paclitaxel and lentinan enhanced TXNIP-NLRP3 interaction, and activated NLRP3 inflammasome whereat interleukin-1beta levels were increased and cell apoptosis was induced.	Paclitaxel	28-38	interleukin 1 beta	Homo sapiens	127-144
25934928-9	2015	Uric acid and ATP mediated a paracrine inflammatory cross-talk between damaged hepatocytes and immune cells and significantly increased the expression of LPS-inducible cytokines, IL-1beta and TNF-alpha, by immune cells.	Uric Acid	0-9	interleukin 1 beta	Homo sapiens	179-187
25934928-9	2015	Uric acid and ATP mediated a paracrine inflammatory cross-talk between damaged hepatocytes and immune cells and significantly increased the expression of LPS-inducible cytokines, IL-1beta and TNF-alpha, by immune cells.	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	179-187
25994595-6	2015	dGEMRIC and biochemical analyzes of the OC constructs showed a reduced glycosaminoglycan (GAG) contents upon IL-1beta administration.	Glycosaminoglycans	71-88	interleukin 1 beta	Homo sapiens	109-117
25957738-0	2015	Lazaroid U-74389G inhibits the osteoblastic differentiation of IL-1beta-indcued aortic valve interstitial cells through glucocorticoid receptor and inhibition of NF-kappaB pathway.	lazaroid u-74389	0-16	interleukin 1 beta	Homo sapiens	63-71
25957738-3	2015	We hypothesized that Lazaroid U-74389G would inhibit the osteoblastic differentiation of AVICs induced by IL-1beta.	lazaroid u	21-31	interleukin 1 beta	Homo sapiens	106-114
25863775-13	2015	CONCLUSIONS: Our results demonstrated that the NLRP3 inflammasome in HDPFs is crucial for IL-1beta secretion in response to LPS plus ATP.	Adenosine Triphosphate	133-136	interleukin 1 beta	Homo sapiens	90-98
26066335-10	2015	Furthermore, curcumin decreases inflammatory cytokines interleukin 1beta and tumor necrosis factor alpha level, increases plasma brain-derived neurotrophic factor levels, and decreases salivary cortisol concentrations compared with placebo group.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	55-104
25863775-9	2015	RESULTS: LPS up-regulated NLRP3 and IL-1beta expression while ATP induced the activation of caspase-1 and the release of IL-1beta in LPS-primed HDPFs.	Adenosine Triphosphate	62-65	interleukin 1 beta	Homo sapiens	121-129
25863775-12	2015	ATP potently promoted ROS generation in HDPFs; N-acetyl cysteine inhibited ROS production, caspase-1 activation and IL-1beta secretion induced by ATP.	Acetylcysteine	47-64	interleukin 1 beta	Homo sapiens	116-124
25863775-12	2015	ATP potently promoted ROS generation in HDPFs; N-acetyl cysteine inhibited ROS production, caspase-1 activation and IL-1beta secretion induced by ATP.	Adenosine Triphosphate	146-149	interleukin 1 beta	Homo sapiens	116-124
26038194-8	2015	Pro-inflammatory cytokines such as interleukin-1-beta and tumor necrosis factor which mediate MC response, are capable of activating p38 MAPK, and might increase serotonin generation through p38 MAPK activation.	Serotonin	162-171	interleukin 1 beta	Homo sapiens	35-53
25909495-9	2015	TLR4 inhibitor TAK242 significantly blocked the up-regulation of NLRP3, IL-1beta, HLA-DR and CD40 induced by soluble MSU while no TAK242 suppression effect on MSU crystals induced IL-1beta up-regulation was found.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	15-21	interleukin 1 beta	Homo sapiens	72-80
25933694-6	2015	We found that TiO2-NPs are internalized in DRG cells and induce apoptosis in a dose dependent manner in both types of cells, ROS production and changes in expression of proinflammatory cytokine IL-1beta.	titanium dioxide	14-18	interleukin 1 beta	Homo sapiens	194-202
26134310-6	2015	Our results demonstrated that PA dose-dependently inhibited LPS-induced TNF-alpha, IL-6, IL-1beta, and PGE2 production.	protocatechuic acid	30-32	interleukin 1 beta	Homo sapiens	89-97
25937253-14	2015	Consistent with the results of in vivo experiment, piscroside C significantly inhibited the expression of inflammatory cytokines (IL-6, IL-8 and IL-1beta) by inhibiting NF-kappaB activation, as resulting decrease in the phosphorylation of IKKbeta, IkappaBalpha and TAK1 in TNF-alpha-stimulated H292 cells.	piscroside C	51-63	interleukin 1 beta	Homo sapiens	145-153
25766132-8	2015	The levels of interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) were significantly decreased by poly P treatment.	Polyphosphates	119-125	interleukin 1 beta	Homo sapiens	14-31
25766132-8	2015	The levels of interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) were significantly decreased by poly P treatment.	Polyphosphates	119-125	interleukin 1 beta	Homo sapiens	33-41
25766132-10	2015	The LPS-induced expressions of IL-1beta and TGF-beta1 in Caco-2/BBE cells and of TNF-alpha in THP-1 cells were reduced by poly P treatment.	Polyphosphates	122-128	interleukin 1 beta	Homo sapiens	31-39
26226164-4	2015	Oral administration of BBR was able to significantly reduce this alcohol-induced damage, inhibit increases of alcohol-induced TNFalpha and IL-1beta expression in gastrointestinal mucosa as well as their upstream signals TLR2 and TLR4, and regulate cytokines that modulate tight junctions.	Berberine	23-26	interleukin 1 beta	Homo sapiens	139-147
26226164-4	2015	Oral administration of BBR was able to significantly reduce this alcohol-induced damage, inhibit increases of alcohol-induced TNFalpha and IL-1beta expression in gastrointestinal mucosa as well as their upstream signals TLR2 and TLR4, and regulate cytokines that modulate tight junctions.	Alcohols	110-117	interleukin 1 beta	Homo sapiens	139-147
26187413-4	2015	CD127(+) ILC1 differentiated to ILC3 in the presence of interleukin-2 (IL-2), IL-23, and IL-1beta dependent on the transcription factor RORgammat, and this process was enhanced in the presence of retinoic acid.	Tretinoin	196-209	interleukin 1 beta	Homo sapiens	89-97
26032420-9	2015	Maturation of pro-IL-1beta during ADE requires caspase-1 and NLRP3, but caspase-1 is suboptimally increased by ADE and can be significantly enhanced by a typical inflammasome agonist, ATP.	Adenosine Triphosphate	184-187	interleukin 1 beta	Homo sapiens	18-26
26136643-6	2015	Compatible with this, secretion of IL-1beta by PBMCs stimulated with LPS alone or LPS plus ATP was increased in BD compared to healthy controls, which was suppressed by caspase-1 inhibitor.	Adenosine Triphosphate	91-94	interleukin 1 beta	Homo sapiens	35-43
26162096-2	2015	Phenformin, a biguanide family member, by its anti-inflammatory properties presents potential for promoting beneficial effects upon vascular cells, however its impact upon the IL-1beta-induced sPLA2 gene expression has not been deeply investigated so far.	Phenformin	0-10	interleukin 1 beta	Homo sapiens	176-184
26156631-8	2015	RESULTS: This study demonstrates that IL-1beta mimics some aspects of tendinopathies with PGE2 induction, MMP expression (mostly MMP1 and MMP3), and increases of type III/I collagen ratio.	Dinoprostone	90-94	interleukin 1 beta	Homo sapiens	38-46
26119735-5	2015	Downregulation of glycolysis by inhibition of Raptor/mTORC1 or HK1 suppressed both pro-IL-1beta maturation and caspase-1 activation in macrophages in response to LPS and ATP.	Adenosine Triphosphate	170-173	interleukin 1 beta	Homo sapiens	83-95
26119741-2	2015	Early studies showed that EV71-infected patients with severe complications exhibited elevated plasma levels of IL-1beta, indicating that EV71 may activate inflammasomes.	ev71	26-30	interleukin 1 beta	Homo sapiens	111-119
26162096-4	2015	Here we find that 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide (AICAR) treatment strongly repressed IL-1beta-induced sPLA2 expression at least at the transcriptional level.	5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleotide	18-72	interleukin 1 beta	Homo sapiens	110-118
26162096-4	2015	Here we find that 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide (AICAR) treatment strongly repressed IL-1beta-induced sPLA2 expression at least at the transcriptional level.	acadesine	74-79	interleukin 1 beta	Homo sapiens	110-118
26647627-7	2015	Stimulation of Caco-2 with pro-inflammatory factors (LPS and IL-1beta) resulted in an up-expression of iNOS mRNA at 6 and 12 h. Cells exposed to IP6 only revealed significant reduction in iNOS gene transcription after 12 h. A decrease in iNOS transcription by IP6 following the gene induction by proinflammatory agents in 6 and 12 h lasting cultures was also determined.	Phytic Acid	260-263	interleukin 1 beta	Homo sapiens	61-69
26005910-8	2015	Moreover, Ang II-induced increases in the expression of NLRP3, ASC, caspase-1, IL-1beta, and IL-18 were significantly inhibited by pretreatment with the ERS inhibitor 4-PBA (5 mmol/L).	4-phenylbutylamine	167-172	interleukin 1 beta	Homo sapiens	79-87
24854157-6	2015	Interleukin-1 beta (IL-1beta), chemokine (C-X3-C motif) ligand 1 (CX3CL1)/fractalkine and CXCL12/SDF-1 positively correlated with the cocaine symptom severity when using the DSM-IV-TR criteria for cocaine abuse/dependence.	Cocaine	134-141	interleukin 1 beta	Homo sapiens	0-18
26647627-5	2015	In this study, the effect of inositol hexaphosphate (IP6), dietary phytochemical, on the mRNA expression of iNOS stimulated with bacterial lipopolysaccharides (Escherichia coli and Salmonella typhimurium) and IL-1beta in intestinal cells Caco-2 for 6 and 12 h was investigated.	Phytic Acid	29-51	interleukin 1 beta	Homo sapiens	209-217
26647627-5	2015	In this study, the effect of inositol hexaphosphate (IP6), dietary phytochemical, on the mRNA expression of iNOS stimulated with bacterial lipopolysaccharides (Escherichia coli and Salmonella typhimurium) and IL-1beta in intestinal cells Caco-2 for 6 and 12 h was investigated.	Phytic Acid	53-56	interleukin 1 beta	Homo sapiens	209-217
25656973-9	2015	IL-1beta also induced COX-2 mRNA expression and prostaglandin release.	Prostaglandins	48-61	interleukin 1 beta	Homo sapiens	0-8
26647627-7	2015	Stimulation of Caco-2 with pro-inflammatory factors (LPS and IL-1beta) resulted in an up-expression of iNOS mRNA at 6 and 12 h. Cells exposed to IP6 only revealed significant reduction in iNOS gene transcription after 12 h. A decrease in iNOS transcription by IP6 following the gene induction by proinflammatory agents in 6 and 12 h lasting cultures was also determined.	Phytic Acid	145-148	interleukin 1 beta	Homo sapiens	61-69
25704622-8	2015	Pre-treatment with simvastatin (S-L) reduced IL-6 (P = 0.02), TNF-alpha (P = 0.02), and MMP-9 (P = 0.01); post-treatment (L-S) reduced IL-1beta (P = 0.02) and TNF-alpha (P = 0.04), while simultaneous treatment (L+S) did not reduce any of the cytokines tested.	Simvastatin	19-30	interleukin 1 beta	Homo sapiens	135-143
25704622-9	2015	Simvastatin reduced the molar ratio of TNF-alpha/sTNFR1 or R2 and IL-1beta/sIL-1R2 (P = 0.01 and 0.04 in S-L group; P = 0.01 and 0.004 in L-S group, respectively).	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	66-74
25958832-0	2015	Identification of IL-1beta and LPS as optimal activators of monolayer and alginate-encapsulated mesenchymal stromal cell immunomodulation using design of experiments and statistical methods.	Alginates	74-82	interleukin 1 beta	Homo sapiens	18-26
25913073-2	2015	To clarify the mechanism of titanium dioxide nanoparticles (TiO2 NPs)-enhanced gingival inflammation, we conducted the full-scale metabolomic analyses of human gingival fibroblast cells treated with IL-1beta alone or in combination with TiO2 NPs.	titanium dioxide	28-44	interleukin 1 beta	Homo sapiens	199-207
25913073-2	2015	To clarify the mechanism of titanium dioxide nanoparticles (TiO2 NPs)-enhanced gingival inflammation, we conducted the full-scale metabolomic analyses of human gingival fibroblast cells treated with IL-1beta alone or in combination with TiO2 NPs.	titanium dioxide	60-64	interleukin 1 beta	Homo sapiens	199-207
25913073-4	2015	TiO2 NPs significantly enhanced the IL-1beta-induced prostaglandin E2 production and COX-1 and COX-2 protein expression.	titanium dioxide	0-4	interleukin 1 beta	Homo sapiens	36-44
25913073-4	2015	TiO2 NPs significantly enhanced the IL-1beta-induced prostaglandin E2 production and COX-1 and COX-2 protein expression.	Dinoprostone	53-69	interleukin 1 beta	Homo sapiens	36-44
25913073-5	2015	IL-1beta reduced the intracellular concentrations of overall primary metabolites especially those of amino acid, urea cycle, polyamine, S-adenosylmethione and glutathione synthetic pathways.	Urea	113-117	interleukin 1 beta	Homo sapiens	0-8
25913073-5	2015	IL-1beta reduced the intracellular concentrations of overall primary metabolites especially those of amino acid, urea cycle, polyamine, S-adenosylmethione and glutathione synthetic pathways.	Polyamines	125-134	interleukin 1 beta	Homo sapiens	0-8
25913073-5	2015	IL-1beta reduced the intracellular concentrations of overall primary metabolites especially those of amino acid, urea cycle, polyamine, S-adenosylmethione and glutathione synthetic pathways.	S-Adenosylmethionine	136-154	interleukin 1 beta	Homo sapiens	0-8
25913073-5	2015	IL-1beta reduced the intracellular concentrations of overall primary metabolites especially those of amino acid, urea cycle, polyamine, S-adenosylmethione and glutathione synthetic pathways.	Glutathione	159-170	interleukin 1 beta	Homo sapiens	0-8
25913073-6	2015	The addition of TiO2 NPs further augmented these IL-1beta-induced metabolic changes, recommending careful use of dental materials containing TiO2 NPs towards patients with gingivitis or periodontitis.	titanium dioxide	16-20	interleukin 1 beta	Homo sapiens	49-57
25913073-6	2015	The addition of TiO2 NPs further augmented these IL-1beta-induced metabolic changes, recommending careful use of dental materials containing TiO2 NPs towards patients with gingivitis or periodontitis.	titanium dioxide	141-145	interleukin 1 beta	Homo sapiens	49-57
25958832-7	2015	The screen revealed that LPS and IL-1beta potently activated monolayer MSCs to enhance PGE2 production and attenuate macrophage TNF-alpha.	Dinoprostone	87-91	interleukin 1 beta	Homo sapiens	33-41
25958832-8	2015	Activation by LPS and IL-1beta together synergistically increased MSC PGE2, but did not synergistically reduce macrophage TNF-alpha.	Dinoprostone	70-74	interleukin 1 beta	Homo sapiens	22-30
26074413-7	2015	FMF WBCs exhibited lower NLRP3 and active caspase-1 protein expression compared to healthy individuals, and LPS/ATP treatment resulted in significantly lower intracellular IL-1beta levels in FMF patients.	Adenosine Triphosphate	112-115	interleukin 1 beta	Homo sapiens	172-180
25109682-3	2015	Reactive oxygen species (ROS) are major mediators of the NLRP3/IL-1beta interaction.	Reactive Oxygen Species	0-23	interleukin 1 beta	Homo sapiens	63-71
25109682-3	2015	Reactive oxygen species (ROS) are major mediators of the NLRP3/IL-1beta interaction.	Reactive Oxygen Species	25-28	interleukin 1 beta	Homo sapiens	63-71
25109682-9	2015	MSU-induced IL-1beta secretion and NLRP3 inflammasome activation were inhibited by the knockdown of Nrf2 and via the HO-1 inhibitor zinc (II) protoporphyrin IX (ZnPP).	zinc;3-[7,12-bis(ethenyl)-18-(3-hydroperoxyprop-1-en-2-yl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid	132-159	interleukin 1 beta	Homo sapiens	12-20
25109682-9	2015	MSU-induced IL-1beta secretion and NLRP3 inflammasome activation were inhibited by the knockdown of Nrf2 and via the HO-1 inhibitor zinc (II) protoporphyrin IX (ZnPP).	zinc protoporphyrin	161-165	interleukin 1 beta	Homo sapiens	12-20
25908506-9	2015	Effects of vitamin D3 supplementation on levels of IL1beta were inconsistent when stratified by weight loss.	Cholecalciferol	11-21	interleukin 1 beta	Homo sapiens	51-58
26074413-8	2015	Likewise, LPS/ATP induced caspase-1-dependent IL-1beta release at significantly lower amounts in the FMF group (1182+-192 versus 2134+-245pg/mL in controls, p=0.004).	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	46-54
26074413-9	2015	Consistently, THP-1 cells transfected with FMF-associated M694V mutant pyrin displayed lower LPS/ATP-induced IL-1beta compared with wild-type pyrin-transfected cells.	Adenosine Triphosphate	97-100	interleukin 1 beta	Homo sapiens	109-117
26339358-5	2015	Honokiol inhibited the expression levels of IL-1beta, TNF-alpha, GM-CSF and IL-8 in PBMCs with a dose-dependent manner.	honokiol	0-8	interleukin 1 beta	Homo sapiens	44-52
26170946-0	2015	Chebulagic acid inhibits the LPS-induced expression of TNF-alpha and IL-1beta in endothelial cells by suppressing MAPK activation.	chebulagic acid	0-15	interleukin 1 beta	Homo sapiens	69-77
25737402-6	2015	Western blot analysis was performed to identify whether resveratrol modulated the interleukin (IL)-1beta-induced expression of HIF-2alpha in human chondrocytes.	Resveratrol	56-67	interleukin 1 beta	Homo sapiens	82-104
25432967-9	2015	For females, results from IFN-gamma-treated cells showed positive correlations between testosterone levels and IL-1beta responses to endotoxin for both risk groups and TNF-alpha for the high-risk group.	Testosterone	87-99	interleukin 1 beta	Homo sapiens	111-119
25972527-9	2015	Quercetin changed Deltaquercetin - Deltaplacebo for sE-selectin by -7.4 ng/mL (95% CI: -14.3, -0.56; P = 0.03), that for IL-1beta by -0.23 pg/mL (95% CI: -0.40, -0.06; P = 0.009), and that for the z score for inflammation by -0.33 (95% CI: -0.60, -0.05; P = 0.02).	Quercetin	0-9	interleukin 1 beta	Homo sapiens	121-129
26339358-7	2015	Furthermore, the mRNA and protein expression of IL-1beta, GM-CSF and IL-8 were up-regulated when the PBMCs exposure to TNF-alpha, however, honokiol treatment significantly reversed the expression of IL-1beta, TNF-alpha and GM-CSF in response to TNF-alpha with a dose-dependent manner.	honokiol	139-147	interleukin 1 beta	Homo sapiens	48-56
26339358-7	2015	Furthermore, the mRNA and protein expression of IL-1beta, GM-CSF and IL-8 were up-regulated when the PBMCs exposure to TNF-alpha, however, honokiol treatment significantly reversed the expression of IL-1beta, TNF-alpha and GM-CSF in response to TNF-alpha with a dose-dependent manner.	honokiol	139-147	interleukin 1 beta	Homo sapiens	199-207
26339358-8	2015	CONCLUSIONS: This study demonstrates that honokiol could possess potential anti-inflammatory effects and inhibits TNF-alpha-induced IL-1beta, GM-CSF and IL-8 production in PBMCs from rheumatoid arthritis patients.	honokiol	42-50	interleukin 1 beta	Homo sapiens	132-140
26114647-10	2015	Leishmania-dependent suppression of IL-1beta secretion is accompanied by an inhibition of reactive oxygen species (ROS) production that has previously been shown to be associated with NLRP3 inflammasome activation.	Reactive Oxygen Species	115-118	interleukin 1 beta	Homo sapiens	36-44
25916804-11	2015	Furthermore, AS-IV reduced the production of reactive oxygen species, malondialdehyde, interleukin-1beta and tumor necrosis factor-alpha of the BaP-treated EPCs.	Benzo(a)pyrene	144-147	interleukin 1 beta	Homo sapiens	87-136
26222747-0	2015	Hydrogen Peroxide-Producing Lactobacilli Are Associated With Lower Levels of Vaginal Interleukin-1beta, Independent of Bacterial Vaginosis.	Hydrogen Peroxide	0-17	interleukin 1 beta	Homo sapiens	85-102
26222747-8	2015	In women with and without BV, IL-1beta was lower in the H2O2+ groups.	Hydrogen Peroxide	56-60	interleukin 1 beta	Homo sapiens	30-38
26112052-10	2015	However, steroid treatment significantly decreased pro-inflammatory cytokines IL-1beta, IL-8, TNF and IFN-gamma at the time of organ procurement.	Steroids	9-16	interleukin 1 beta	Homo sapiens	78-86
25882540-4	2015	Confirmatory enzyme-linked immunosorbent assays (ELISAs) showed that PGF2alpha stimulated increased output of interleukin (IL) 1beta, IL6, IL8 (CXCL8) and monocyte chemotactic protein-1 (MCP1, also known as chemokine (c-c motif) ligand 2, CCL2) by HUSMCs isolated from both upper and lower uterine segments.	Dinoprost	69-78	interleukin 1 beta	Homo sapiens	110-132
25882540-10	2015	Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output.	Dinoprost	27-36	interleukin 1 beta	Homo sapiens	45-52
25882540-10	2015	Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output.	Dinoprost	27-36	interleukin 1 beta	Homo sapiens	217-224
25791922-6	2015	As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1beta secretion.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	168-176
25930996-6	2015	LPS-induced AMPK activation and interleukin 1beta (IL-1beta) release were reduced with fenoterol pretreatment of THP-1 cells.	Fenoterol	87-96	interleukin 1 beta	Homo sapiens	32-49
25930996-6	2015	LPS-induced AMPK activation and interleukin 1beta (IL-1beta) release were reduced with fenoterol pretreatment of THP-1 cells.	Fenoterol	87-96	interleukin 1 beta	Homo sapiens	51-59
25930996-7	2015	SiRNA knockdown of beta-arrestin-2 abolished the fenoterol inhibition of LPS-induced AMPK activation and interleukin 1beta (IL-1beta) release, thus beta-arrestin-2 mediated the anti-inflammatory effects of fenoterol on LPS-treated THP-1 cells.	Fenoterol	49-58	interleukin 1 beta	Homo sapiens	105-122
25930996-7	2015	SiRNA knockdown of beta-arrestin-2 abolished the fenoterol inhibition of LPS-induced AMPK activation and interleukin 1beta (IL-1beta) release, thus beta-arrestin-2 mediated the anti-inflammatory effects of fenoterol on LPS-treated THP-1 cells.	Fenoterol	49-58	interleukin 1 beta	Homo sapiens	124-132
25930996-7	2015	SiRNA knockdown of beta-arrestin-2 abolished the fenoterol inhibition of LPS-induced AMPK activation and interleukin 1beta (IL-1beta) release, thus beta-arrestin-2 mediated the anti-inflammatory effects of fenoterol on LPS-treated THP-1 cells.	Fenoterol	206-215	interleukin 1 beta	Homo sapiens	105-122
25930996-7	2015	SiRNA knockdown of beta-arrestin-2 abolished the fenoterol inhibition of LPS-induced AMPK activation and interleukin 1beta (IL-1beta) release, thus beta-arrestin-2 mediated the anti-inflammatory effects of fenoterol on LPS-treated THP-1 cells.	Fenoterol	206-215	interleukin 1 beta	Homo sapiens	124-132
25930996-9	2015	These results suggested the beta2-AR agonist fenoterol inhibited LPS-induced AMPK activation and IL-1beta release via beta-arrestin-2 in THP-1 cells.	Fenoterol	45-54	interleukin 1 beta	Homo sapiens	97-105
26114549-7	2015	Treatment with DHA before stimulation significantly affected the expression of 116 IL-1beta-deregulated genes, counter-regulating the expression of 55 genes among those decreased and of 61 among those increased.	Docosahexaenoic Acids	15-18	interleukin 1 beta	Homo sapiens	83-91
26114647-10	2015	Leishmania-dependent suppression of IL-1beta secretion is accompanied by an inhibition of reactive oxygen species (ROS) production that has previously been shown to be associated with NLRP3 inflammasome activation.	Reactive Oxygen Species	90-113	interleukin 1 beta	Homo sapiens	36-44
26110640-14	2015	Dh404 significantly decreased production of cytokines/chemokines including IL-1beta, IL-6, IFN-gamma and MCP-1.	dh404	0-5	interleukin 1 beta	Homo sapiens	75-83
26086963-6	2015	Moreover, SERCA2b protein but not mRNA levels were rescued by treatment with the NOS inhibitor l-NMMA (NG-monomethyl L-arginine), whereas the NO donor SNAP (S-nitroso-N-acetyl-D,L-penicillamine) and the AMPK activator AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) recapitulated the effects of IL-1beta on SERCA2b protein stability.	omega-N-Methylarginine	95-101	interleukin 1 beta	Homo sapiens	301-309
26107738-4	2015	Here, we report that vitamin D treatment during differentiation of monocytes into DCs markedly enhanced their ability to secrete TNF-alpha, IL-6, IL-1beta and IL-23.	Vitamin D	21-30	interleukin 1 beta	Homo sapiens	146-154
26091108-9	2015	IL-4 or IL-13 decreased MWCNT-induced IL-1beta secretion by THP-1 cells and reduced pro-caspase-1 but not pro-IL-1beta.	mwcnt	24-29	interleukin 1 beta	Homo sapiens	38-46
25871410-0	2015	Hyaluronic Acid Based Hydrogels Attenuate Inflammatory Receptors and Neurotrophins in Interleukin-1beta Induced Inflammation Model of Nucleus Pulposus Cells.	Hyaluronic Acid	0-15	interleukin 1 beta	Homo sapiens	86-103
26086415-7	2015	In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1beta, TNF-alpha and Bax, and up-regulated IkappaB-alpha and Bcl-2 expression compared with OGD group.	ip	13-15	interleukin 1 beta	Homo sapiens	105-113
26040555-12	2015	In addition, anti-dsDNA antibodies also significantly increased the activation of NF-kappaB and upregulated the expression of IL-1beta, TNF-alpha and MCP-1, which were suppressed by pretreatment of HMCs with chemical ER stress inhibitor 4-PBA.	4-phenylbutylamine	237-242	interleukin 1 beta	Homo sapiens	126-134
25797286-0	2015	Taraxasterol inhibits IL-1beta-induced inflammatory response in human osteoarthritic chondrocytes.	taraxasterol	0-12	interleukin 1 beta	Homo sapiens	22-30
25797286-4	2015	In order to provide a scientific basis for the applicability of taraxasterol in OA, the anti-inflammatory effects of taraxasterol on IL-1beta-stimulated osteoarthritic chondrocytes were investigated.	taraxasterol	117-129	interleukin 1 beta	Homo sapiens	133-141
25797286-8	2015	Our results demonstrated that taraxasterol dose-dependently suppressed MMP-1, MMP3, MMP13, PGE2 and NO production induced by IL-1beta.	taraxasterol	30-42	interleukin 1 beta	Homo sapiens	125-133
25797286-8	2015	Our results demonstrated that taraxasterol dose-dependently suppressed MMP-1, MMP3, MMP13, PGE2 and NO production induced by IL-1beta.	Dinoprostone	91-95	interleukin 1 beta	Homo sapiens	125-133
25797286-10	2015	Western blot analysis showed that taraxasterol suppressed IL-1beta-induced NF-kappaB activation in a dose-dependent manner.	taraxasterol	34-46	interleukin 1 beta	Homo sapiens	58-66
25996641-0	2015	Phloretin inhibits interleukin-1beta-induced COX-2 and ICAM-1 expression through inhibition of MAPK, Akt, and NF-kappaB signaling in human lung epithelial cells.	Phloretin	0-9	interleukin 1 beta	Homo sapiens	19-36
25712888-0	2015	Inhibition of matrix metalloproteinase-13 expression in IL-1beta-treated articular chondrocytes by a steroidal saponin, spicatoside A, and its cellular mechanisms of action.	Saponins	111-118	interleukin 1 beta	Homo sapiens	56-64
25712888-0	2015	Inhibition of matrix metalloproteinase-13 expression in IL-1beta-treated articular chondrocytes by a steroidal saponin, spicatoside A, and its cellular mechanisms of action.	5-(1-(glucopyranosyloxymethyl)ethenyl)-2-methyl-2-cyclohexen-1-one	120-133	interleukin 1 beta	Homo sapiens	56-64
25712888-4	2015	Among these, only spicatoside A and 25(S)-ruscogenin were found to inhibit MMP-13 expression in IL-1beta-treated SW1353 cells at a pharmacologically-relevant concentration of 10 muM.	5-(1-(glucopyranosyloxymethyl)ethenyl)-2-methyl-2-cyclohexen-1-one	18-31	interleukin 1 beta	Homo sapiens	96-104
25894080-9	2015	IL-1beta and TNF-alpha levels were reduced in the pitavastatin-preconditioned group.	pitavastatin	50-62	interleukin 1 beta	Homo sapiens	0-8
25914924-8	2015	Additionally, food and water deprivation significantly increased hippocampus IL-1beta while food and water deprivation only increased hypothalamus IL-1beta in stress-susceptible animals.	Water	23-28	interleukin 1 beta	Homo sapiens	77-85
25914924-8	2015	Additionally, food and water deprivation significantly increased hippocampus IL-1beta while food and water deprivation only increased hypothalamus IL-1beta in stress-susceptible animals.	Water	101-106	interleukin 1 beta	Homo sapiens	147-155
25996641-2	2015	In this study, we evaluated the suppressive effects of phloretin on intercellular adhesion molecule 1 (ICAM-1) and cyclooxygenase (COX)-2 expression in IL-1beta-stimulated human lung epithelial A549 cells.	Phloretin	55-64	interleukin 1 beta	Homo sapiens	152-160
25986991-1	2015	The aim of the present study was to investigate the effect of paeoniflorin (Pae) on recombinant human interleukin-1beta (rhIL-1beta)-stimulated human peripheral blood mononuclear cells (PBMCs) in vitro.	peoniflorin	62-74	interleukin 1 beta	Homo sapiens	102-119
25580516-4	2015	We previously reported that Ehx markedly induced interleukin-1beta (IL-1beta) production in human macrophages.	(9aR)-9a-(dioxidanyl)-1,9-dihydrocarbazole	28-31	interleukin 1 beta	Homo sapiens	49-66
25580516-4	2015	We previously reported that Ehx markedly induced interleukin-1beta (IL-1beta) production in human macrophages.	(9aR)-9a-(dioxidanyl)-1,9-dihydrocarbazole	28-31	interleukin 1 beta	Homo sapiens	68-76
25975581-4	2015	The anti-inflammatory effect of isoacteoside was investigated in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor alpha (TNF-alpha) secretion and mRNA expression by ELISA and RT-PCR, respectively.	Calcium	148-155	interleukin 1 beta	Homo sapiens	189-211
25975581-4	2015	The anti-inflammatory effect of isoacteoside was investigated in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor alpha (TNF-alpha) secretion and mRNA expression by ELISA and RT-PCR, respectively.	Calcimycin	166-172	interleukin 1 beta	Homo sapiens	189-211
25986991-1	2015	The aim of the present study was to investigate the effect of paeoniflorin (Pae) on recombinant human interleukin-1beta (rhIL-1beta)-stimulated human peripheral blood mononuclear cells (PBMCs) in vitro.	peoniflorin	76-79	interleukin 1 beta	Homo sapiens	102-119
25847326-6	2015	In HTNV-infected THP-1 cells, reactive oxygen species release, but not extracellular adenosine triphosphate, was crucial for IL-1beta production.	Reactive Oxygen Species	30-53	interleukin 1 beta	Homo sapiens	125-133
25975581-6	2015	Isoacteoside significantly suppressed the production and mRNA expression of proinflammatory cytokines including IL-1beta, IL-6, IL-8 and TNF-alpha in PMACI-stimulated HMC-1 cells without cytotoxicity.	isoacteoside	0-12	interleukin 1 beta	Homo sapiens	112-120
26261550-5	2015	Results demonstrated that high glucose promoted the pre-inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6 in patients with T2DM or in SV40 MES 13 cells.	Glucose	31-38	interleukin 1 beta	Homo sapiens	99-107
25917098-11	2015	Additionally, constitutive IL-1beta secretion from LPS-primed PBMCs of cryopyrin-associated periodic fever syndromes patients was substantially reduced by high doses of PGE2.	Dinoprostone	169-173	interleukin 1 beta	Homo sapiens	27-35
25872797-0	2015	Hydrogen sulfide attenuates IL-1beta-induced inflammatory signaling and dysfunction of osteoarthritic chondrocytes.	Hydrogen Sulfide	0-16	interleukin 1 beta	Homo sapiens	28-36
25872797-9	2015	Our results revealed that H2S markedly reversed the effects of IL-1beta on the gene expression of COX-2, MMP-13 and iNOS and on the production of MMP-13, PGE2 and NO.	Hydrogen Sulfide	26-29	interleukin 1 beta	Homo sapiens	63-71
25872797-9	2015	Our results revealed that H2S markedly reversed the effects of IL-1beta on the gene expression of COX-2, MMP-13 and iNOS and on the production of MMP-13, PGE2 and NO.	Dinoprostone	154-158	interleukin 1 beta	Homo sapiens	63-71
25872797-10	2015	In addition, H2S inhibited the activation of the extracellular signal-regulated kinase (ERK)/IkappaBalpha/NF-kappaB pathway which was induced by IL-1beta.	Hydrogen Sulfide	13-16	interleukin 1 beta	Homo sapiens	145-153
26025257-2	2015	Within term-equivalent rat brains exposed to systemic lipopolysaccharide (LPS) plus HI, it was previously showed that neurons produce IL-1beta earlier than do glial cells, and that blocking IL-1 was neuroprotective.	hi	84-86	interleukin 1 beta	Homo sapiens	134-138
26072084-10	2015	It was concluded that LXA4 inhibits the LPS-induced production of TNF-alpha and IL-1beta in NHEKs by up-regulating SOCS2 and down-regulating TRAF6.	lipoxin A4	22-26	interleukin 1 beta	Homo sapiens	80-88
25801720-8	2015	4HBA significantly reduced IL-1beta secretion but none of the flavonoids or metabolites significantly modified IL-10 secretion.	4-hydroxybenzoic acid	0-4	interleukin 1 beta	Homo sapiens	27-35
25834143-0	2015	Helicobacter pylori induces IL-1beta and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway.	Reactive Oxygen Species	132-135	interleukin 1 beta	Homo sapiens	28-36
25834143-9	2015	Furthermore, NAC treatment could inhibit NLRP3 inflammasome formation and caspase-1 activation and suppress the release of IL-1beta and IL-18 from H. pylori-infected THP-1 cells.	Acetylcysteine	13-16	interleukin 1 beta	Homo sapiens	123-131
26521440-6	2015	Kaempferol significantly decreased the release of histamine, IL-6, IL-8, IL-1beta and TNF-alpha of activated HMC-1 mast cells (P&lt;0.01).	kaempferol	0-10	interleukin 1 beta	Homo sapiens	73-81
26025257-7	2015	RESULTS: In LPS+HI-exposed forebrains, neuronal IL-1beta was first detected in infarcted neocortical and striatal areas and later in glial cells of the adjacent white matter.	hi	16-18	interleukin 1 beta	Homo sapiens	48-56
26010541-12	2015	Cambinol decreased tumor necrosis factor-alpha or interleukin-1 beta-induced increases of ceramide and cell death in primary neurons.	cambinol	0-8	interleukin 1 beta	Homo sapiens	50-68
26010541-12	2015	Cambinol decreased tumor necrosis factor-alpha or interleukin-1 beta-induced increases of ceramide and cell death in primary neurons.	Ceramides	90-98	interleukin 1 beta	Homo sapiens	50-68
25978411-5	2015	We found that NS1 proteins derived from both highly pathogenic and low pathogenic strains efficiently decreased secretion of IL-1beta and IL-18 from THP-1 cells treated with LPS and ATP.	Adenosine Triphosphate	182-185	interleukin 1 beta	Homo sapiens	125-133
25903737-7	2015	Pre-treatment with inhibitors of the pathway, LY294002 and rapamycin, decreased the expression of p-Akt and p70S6K and alleviated the morphological changes induced by IL-1beta in hippocampal neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	interleukin 1 beta	Homo sapiens	167-175
25903737-7	2015	Pre-treatment with inhibitors of the pathway, LY294002 and rapamycin, decreased the expression of p-Akt and p70S6K and alleviated the morphological changes induced by IL-1beta in hippocampal neurons.	Sirolimus	59-68	interleukin 1 beta	Homo sapiens	167-175
26236481-7	2015	Mechanistically, NOSH-aspirin, but not aspirin, was able to reduce the production/release of interleukin-1 beta (IL-1beta) during Cg-induced paw inflammation.	4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-((4-(nitrooxy)butanoyl)oxy)benzoate	17-29	interleukin 1 beta	Homo sapiens	93-111
26236481-7	2015	Mechanistically, NOSH-aspirin, but not aspirin, was able to reduce the production/release of interleukin-1 beta (IL-1beta) during Cg-induced paw inflammation.	4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-((4-(nitrooxy)butanoyl)oxy)benzoate	17-29	interleukin 1 beta	Homo sapiens	113-121
26236481-7	2015	Mechanistically, NOSH-aspirin, but not aspirin, was able to reduce the production/release of interleukin-1 beta (IL-1beta) during Cg-induced paw inflammation.	Aspirin	22-29	interleukin 1 beta	Homo sapiens	93-111
26236481-7	2015	Mechanistically, NOSH-aspirin, but not aspirin, was able to reduce the production/release of interleukin-1 beta (IL-1beta) during Cg-induced paw inflammation.	Aspirin	22-29	interleukin 1 beta	Homo sapiens	113-121
26236481-11	2015	The enhanced effects of NOSH-aspirin seems to be due to its ability to reduce the production of pronociceptive cytokines such as IL-1 beta and directly block hyperalgesia caused by a directly acting hyperalgesic mediator in a mechanism dependent on modulation of KATP channels.	4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-((4-(nitrooxy)butanoyl)oxy)benzoate	24-36	interleukin 1 beta	Homo sapiens	129-138
25992485-3	2015	IL-1beta, COX-2-dependent PGE2 activated the PI3-K/AKT and p38 signaling pathways, which were in turn responsible for MMP-1 synthesis via NF-kappaB- and c-Jun-transactivating pathways.	Dinoprostone	26-30	interleukin 1 beta	Homo sapiens	0-8
25770182-5	2015	Here, we demonstrated that CO inhibited caspase-1 activation and the secretion of IL-1beta and IL-18 in response to lipopolysaccharide (LPS) and ATP treatment in bone marrow-derived macrophages.	Adenosine Triphosphate	145-148	interleukin 1 beta	Homo sapiens	82-90
25809479-0	2015	Interleukin-1beta-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats.	Serine	44-47	interleukin 1 beta	Homo sapiens	0-17
25961579-7	2015	Curcumin treatment completely abrogated the expression of IL-1beta-induced IL-6 in these cells.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	58-66
25961579-10	2015	Furthermore, curcumin attenuated IL-1beta-induced IL-6 promoter reporter activity suggesting transcriptional regulation.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	33-41
25961579-12	2015	Expression of IL-1beta-induced p50 mRNA was repressed by curcumin while p65 mRNA was not affected.	Curcumin	57-65	interleukin 1 beta	Homo sapiens	14-22
25961579-14	2015	This effect is at least partly mediated through the deactivation of IKK, since IL-1beta-induced IKKalpha/beta phosphorylation is decreased upon curcumin treatment.	Curcumin	144-152	interleukin 1 beta	Homo sapiens	79-87
25809479-0	2015	Interleukin-1beta-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats.	Hyaluronic Acid	186-196	interleukin 1 beta	Homo sapiens	0-17
25809479-3	2015	In the present work, we studied how IL-1beta turns on the monocyte adhesion of the hyaluronan coat on human keratinocytes.	Hyaluronic Acid	83-93	interleukin 1 beta	Homo sapiens	36-44
25809479-6	2015	Although IL-1beta caused a small increase in the total amount of CD44, a more marked impact was the decrease of CD44 phosphorylation at serine 325.	Serine	136-142	interleukin 1 beta	Homo sapiens	9-17
25809479-10	2015	In conclusion, treatment of human keratinocytes with IL-1beta changes the structure of their hyaluronan coat by influencing the amount, post-translational modification, and cytoskeletal association of CD44, thus enhancing monocyte retention on keratinocytes.	Hyaluronic Acid	93-103	interleukin 1 beta	Homo sapiens	53-61
25651569-5	2015	Soluble uric acid stimulated NLRP3 inflammasomes to produce IL-1beta in macrophages.	Uric Acid	8-17	interleukin 1 beta	Homo sapiens	60-68
25725371-4	2015	Here, we demonstrate that human skin MCs display substantial susceptibility to RA by which they are instructed to increase pro-inflammatory mediators (IL-1beta, IL-8, TNF-alpha) but not histamine release.	Tretinoin	79-81	interleukin 1 beta	Homo sapiens	151-159
25651569-6	2015	Uric acid-induced MitoSOX mediates NLRP3 activation and IL-1beta secretion.	Uric Acid	0-9	interleukin 1 beta	Homo sapiens	56-64
25651569-9	2015	Lowering the serum uric acid level resulted in improving the albuminuria, tubular injury, macrophage infiltration, and renal IL-1beta (60% of HFD-fed OLETF) independently of glycemic control.	Uric Acid	19-28	interleukin 1 beta	Homo sapiens	125-133
25637483-0	2015	Interleukin-1beta-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and alpha-melanocyte-stimulating hormone prevented these effects.	Glutamic Acid	90-99	interleukin 1 beta	Homo sapiens	0-17
25746333-9	2015	We also found that lower viral replication after LiCl treatment was associated with the reduced mRNA levels of pro-inflammatory IL-8, IL-6, IL-1 beta, tumor necrosis factor alpha and decreased NF-kappaB nuclear translocation.	Lithium Chloride	49-53	interleukin 1 beta	Homo sapiens	140-149
25637483-7	2015	Our results demonstrated that IL-1beta induced a significant decrease of glutamate release after reactivation of the fear memory and this effect was related to calcium concentration in hippocampal synaptosomes.	Glutamic Acid	73-82	interleukin 1 beta	Homo sapiens	30-38
25637483-7	2015	Our results demonstrated that IL-1beta induced a significant decrease of glutamate release after reactivation of the fear memory and this effect was related to calcium concentration in hippocampal synaptosomes.	Calcium	160-167	interleukin 1 beta	Homo sapiens	30-38
25637483-9	2015	Central administration of alpha-MSH prevented the decrease in glutamate release, ERK phosphorylation and zif268 expression induced by IL-1beta.	Glutamic Acid	62-71	interleukin 1 beta	Homo sapiens	134-142
25701684-3	2015	Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic stress-induced inflammation in human corneal epithelial cells (HCECs); b) the ROS-NLRP3-IL-1beta axis activation is associated with environment-induced DE.	Reactive Oxygen Species	45-48	interleukin 1 beta	Homo sapiens	188-196
25616026-7	2015	Increased maternal dietary vitamin D was associated with significant increases in IL-10 release by AEC after stimulation with TNF-alpha/IL-1beta (P = 0.024) or HDM (P = 0.049).	Vitamin D	27-36	interleukin 1 beta	Homo sapiens	136-144
25616026-8	2015	Maternal plasma alpha-tocopherol at 10-12 weeks gestation was positively associated with MIP1alpha (Spearman"s rho 0.242, P = 0.009) and IL-3 (rho 0.189, P = 0.043) responses after TNF-alpha/IL-1beta stimulation and negatively associated with TNF (rho -0.404, P = 0.011) and MIP1beta (rho -0.322, P = 0.046) responses after LPS stimulation.	alpha-Tocopherol	16-32	interleukin 1 beta	Homo sapiens	191-199
25349218-7	2015	Enhanced expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-4, and interleukin-6 in activated mast cells was significantly diminished by SG-HQ2 100 times lower concentration of gallic acid.	Gallic Acid	235-246	interleukin 1 beta	Homo sapiens	87-104
25701684-3	2015	Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic stress-induced inflammation in human corneal epithelial cells (HCECs); b) the ROS-NLRP3-IL-1beta axis activation is associated with environment-induced DE.	Reactive Oxygen Species	178-181	interleukin 1 beta	Homo sapiens	188-196
25701684-11	2015	NAC suppressed hyperosmolarity-induced rises in ROS levels, NLRP3 inflammasome formation and activation, caspase-1 activity and IL-1beta release.	Acetylcysteine	0-3	interleukin 1 beta	Homo sapiens	128-136
25701684-15	2015	ROS-NLRP3-IL-1beta signaling pathway might play a priming role in environment-induced DE development.	Reactive Oxygen Species	0-3	interleukin 1 beta	Homo sapiens	10-18
26191174-0	2015	Diosgenin inhibits IL-1beta-induced expression of inflammatory mediators in human osteoarthritis chondrocytes.	Diosgenin	0-9	interleukin 1 beta	Homo sapiens	19-27
25813103-0	2015	Soluble uric acid increases NALP3 inflammasome and interleukin-1beta expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway.	Uric Acid	8-17	interleukin 1 beta	Homo sapiens	51-68
26191174-5	2015	We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta).	Diosgenin	14-23	interleukin 1 beta	Homo sapiens	109-127
25813103-5	2015	Soluble UA significantly enhanced TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells.	Uric Acid	8-10	interleukin 1 beta	Homo sapiens	58-66
25813103-6	2015	The TLR4 inhibitor, TAK242 effectively blocked the soluble UA-induced upregulation of TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	20-26	interleukin 1 beta	Homo sapiens	110-118
25813103-6	2015	The TLR4 inhibitor, TAK242 effectively blocked the soluble UA-induced upregulation of TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells.	Uric Acid	59-61	interleukin 1 beta	Homo sapiens	110-118
25813103-7	2015	Our findings indicate that soluble UA enhances NALP3 expression, caspase-1 activation, IL-1beta and ICAM-1 production in renal proximal tubule epithelial cells in a TLR4-dependent manner, suggesting the activation of innate immunity in human primary renal proximal tubule epithelial cells by soluble UA.	Uric Acid	35-37	interleukin 1 beta	Homo sapiens	87-95
26191174-5	2015	We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta).	Diosgenin	14-23	interleukin 1 beta	Homo sapiens	129-137
26191174-5	2015	We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta).	Nitric Oxide	52-64	interleukin 1 beta	Homo sapiens	109-127
26191174-5	2015	We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta).	Nitric Oxide	52-64	interleukin 1 beta	Homo sapiens	129-137
26191174-5	2015	We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta).	Dinoprostone	74-90	interleukin 1 beta	Homo sapiens	109-127
26191174-5	2015	We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta).	Dinoprostone	74-90	interleukin 1 beta	Homo sapiens	129-137
26191174-5	2015	We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta).	Dinoprostone	92-96	interleukin 1 beta	Homo sapiens	109-127
26191174-5	2015	We found that diosgenin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by interleukin-1-beta (IL-1beta).	Dinoprostone	92-96	interleukin 1 beta	Homo sapiens	129-137
26191174-6	2015	Diosgenin significantly inhibited the IL-1beta-stimulated expression of metalloproteinase-3 (MMP-3), MMP-13, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in human OA chondrocytes.	Diosgenin	0-9	interleukin 1 beta	Homo sapiens	38-46
26191174-8	2015	Taken together, this study showed that diosgenin can effectively inhibit the IL-1beta-induced expression of inflammatory mediators, suggesting that diosgenin may be a potential agent in the treatment of OA.	Diosgenin	39-48	interleukin 1 beta	Homo sapiens	77-85
26191174-8	2015	Taken together, this study showed that diosgenin can effectively inhibit the IL-1beta-induced expression of inflammatory mediators, suggesting that diosgenin may be a potential agent in the treatment of OA.	Diosgenin	148-157	interleukin 1 beta	Homo sapiens	77-85
25821218-7	2015	SB216763, a GSK-3 inhibitor, selectively inhibited IL-1beta gene expression, whereas the IRE1alpha RNase inhibitor STF083010 suppressed only TNF-alpha production.	SB 216763	0-8	interleukin 1 beta	Homo sapiens	51-59
25639477-0	2015	Vitamin D3 metabolites enhance the NLRP3-dependent secretion of IL-1beta from human THP-1 monocytic cells.	Cholecalciferol	0-10	interleukin 1 beta	Homo sapiens	64-72
25639477-6	2015	Both 1,25(OH)2D3 - and 25(OH)D3 induced IL-1beta release from THP-1 cells, and these effects were blocked with application of the caspase-1 inhibitor YVAD and the NLRP3 inhibitors glyburide and Bay 11-7082.	Calcitriol	5-16	interleukin 1 beta	Homo sapiens	40-48
25639477-6	2015	Both 1,25(OH)2D3 - and 25(OH)D3 induced IL-1beta release from THP-1 cells, and these effects were blocked with application of the caspase-1 inhibitor YVAD and the NLRP3 inhibitors glyburide and Bay 11-7082.	Calcifediol	23-31	interleukin 1 beta	Homo sapiens	40-48
25639477-6	2015	Both 1,25(OH)2D3 - and 25(OH)D3 induced IL-1beta release from THP-1 cells, and these effects were blocked with application of the caspase-1 inhibitor YVAD and the NLRP3 inhibitors glyburide and Bay 11-7082.	YVAD	150-154	interleukin 1 beta	Homo sapiens	40-48
25639477-6	2015	Both 1,25(OH)2D3 - and 25(OH)D3 induced IL-1beta release from THP-1 cells, and these effects were blocked with application of the caspase-1 inhibitor YVAD and the NLRP3 inhibitors glyburide and Bay 11-7082.	Glyburide	180-189	interleukin 1 beta	Homo sapiens	40-48
25639477-6	2015	Both 1,25(OH)2D3 - and 25(OH)D3 induced IL-1beta release from THP-1 cells, and these effects were blocked with application of the caspase-1 inhibitor YVAD and the NLRP3 inhibitors glyburide and Bay 11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	194-205	interleukin 1 beta	Homo sapiens	40-48
25639477-8	2015	The increase in mature IL-1beta elicited by 1,25(OH)2D3 was modest compared to that found for ATP or C. difficile toxins.	Calcitriol	44-55	interleukin 1 beta	Homo sapiens	23-31
25639477-9	2015	However, co-treatment of THP-1 cells with ATP and 1,25(OH)2D3 resulted in more IL-1beta secretion than ATP or 1,25(OH)2D3 alone.	Adenosine Triphosphate	42-45	interleukin 1 beta	Homo sapiens	79-87
25639477-9	2015	However, co-treatment of THP-1 cells with ATP and 1,25(OH)2D3 resulted in more IL-1beta secretion than ATP or 1,25(OH)2D3 alone.	oh)2d3	55-61	interleukin 1 beta	Homo sapiens	79-87
25662545-0	2015	Effects of glucosamine-chondroitin combination on synovial fluid IL-1beta, IL-6, TNF-alpha and PGE2 levels in internal derangements of temporomandibular joint.	Glucosamine	11-22	interleukin 1 beta	Homo sapiens	65-73
25717146-9	2015	MUO SVCs also displayed up-regulation of the A2AR, allowing extracellular adenosine to increase IL-1beta local secretion.	Adenosine	74-83	interleukin 1 beta	Homo sapiens	96-104
25717146-12	2015	Finally, our study reveals a proinflammatory role for adenosine in sustaining IL-1beta production in this tissue.	Adenosine	54-63	interleukin 1 beta	Homo sapiens	78-86
25858413-0	2015	A functional polymorphism in the interleukin-1beta and severity of nicotine dependence in male schizophrenia: a case-control study.	Nicotine	67-75	interleukin 1 beta	Homo sapiens	33-50
25858413-10	2015	Our findings suggest that the IL-1beta-511C/T polymorphism may not be related to schizophrenia or smoking status in Chinese individuals, but may affect the severity of nicotine dependence among male smokers with schizophrenia.	Nicotine	168-176	interleukin 1 beta	Homo sapiens	30-38
25662545-14	2015	CONCLUSIONS: In conclusion, these results might suggest that glucosamine-chondroitin combination significantly increases the MMO and decreases the synovial fluid IL1beta and IL6 levels in internal derangements of TMJ compared to tramadol.	Glucosamine	61-72	interleukin 1 beta	Homo sapiens	162-169
25662545-14	2015	CONCLUSIONS: In conclusion, these results might suggest that glucosamine-chondroitin combination significantly increases the MMO and decreases the synovial fluid IL1beta and IL6 levels in internal derangements of TMJ compared to tramadol.	Chondroitin	73-84	interleukin 1 beta	Homo sapiens	162-169
25687411-7	2015	KLF5 silencing in myometrial cells significantly decreased IL1beta-induced cytokine expression (IL6 and IL8 mRNA expression and release), COX2 mRNA expression, and subsequent release of prostaglandins PGE2 and PGF2 alpha.	Prostaglandins	186-200	interleukin 1 beta	Homo sapiens	59-66
25894680-8	2015	PGZ treatment significantly ameliorated the increase of TNF-alpha and IL-1beta levels in LFD-fed gerbils, not in the HFD-fed gerbils.	Pioglitazone	0-3	interleukin 1 beta	Homo sapiens	70-78
25894680-11	2015	These results suggest that PGZ ameliorates the neuronal damage induced by ischemia by maintaining the TNF-alpha, IL-1beta, SOD and MDA levels in LFD-fed gerbils.	Pioglitazone	27-30	interleukin 1 beta	Homo sapiens	113-121
25919263-9	2015	Both studies also report a significant reduction of interleukin-1beta in the wound exudate, supporting a mechanism involving a pulsed electromagnetic field effect on nitric oxide/cyclic guanosine monophosphate signaling, which modulates the body"s antiinflammatory pathways.	Nitric Oxide	166-178	interleukin 1 beta	Homo sapiens	52-69
25919263-9	2015	Both studies also report a significant reduction of interleukin-1beta in the wound exudate, supporting a mechanism involving a pulsed electromagnetic field effect on nitric oxide/cyclic guanosine monophosphate signaling, which modulates the body"s antiinflammatory pathways.	Cyclic GMP	179-209	interleukin 1 beta	Homo sapiens	52-69
25687411-7	2015	KLF5 silencing in myometrial cells significantly decreased IL1beta-induced cytokine expression (IL6 and IL8 mRNA expression and release), COX2 mRNA expression, and subsequent release of prostaglandins PGE2 and PGF2 alpha.	Dinoprostone	201-205	interleukin 1 beta	Homo sapiens	59-66
25687411-7	2015	KLF5 silencing in myometrial cells significantly decreased IL1beta-induced cytokine expression (IL6 and IL8 mRNA expression and release), COX2 mRNA expression, and subsequent release of prostaglandins PGE2 and PGF2 alpha.	Dinoprost	210-220	interleukin 1 beta	Homo sapiens	59-66
26121854-7	2015	NF-kappaB blockers PDTC and sodium ferulateresisted the effects of H2O2 on A549 cells, that decreased the mRNA and protein expression of NALP3 and the mRNA expression of NF-kappaB (P65), reduced the degeneration of IkappaBalpha and the secretion of IL-1beta (P&lt;0.	Sodium	28-34	interleukin 1 beta	Homo sapiens	249-257
26081514-7	2015	RESULTS: At the concentrations of 0-10 mmol/L for 0-48 h, metformin in concentration and time-dependent ways promoted the expression of IL-10 mRNA and inhibited the mRNA expression of IL-1beta in RAW264.7 macrophages (both P &lt; 0.05).	Metformin	58-67	interleukin 1 beta	Homo sapiens	184-192
26121854-7	2015	NF-kappaB blockers PDTC and sodium ferulateresisted the effects of H2O2 on A549 cells, that decreased the mRNA and protein expression of NALP3 and the mRNA expression of NF-kappaB (P65), reduced the degeneration of IkappaBalpha and the secretion of IL-1beta (P&lt;0.	Hydrogen Peroxide	67-71	interleukin 1 beta	Homo sapiens	249-257
25747143-5	2015	Nano-11 induced increased expression of costimulatory molecules and the secretion of IL-1beta and IL-12p40 by dendritic cells.	nano-11	0-7	interleukin 1 beta	Homo sapiens	85-93
26081514-8	2015	In metformin-treated cells, the expressions of Arg1 (P = 0.009), IL-10 (P = 0.015) and IL-4 (P = 0.001) mRNA increased while the expressions of IL-1beta (P = 0.001) and IL-6 (P = 0.032) mRNA decreased.	Metformin	3-12	interleukin 1 beta	Homo sapiens	144-152
25661535-6	2015	Furthermore, gemigliptin reduced LPS-induced expression of adhesion molecules and inflammatory cytokines such as vascular cell adhesion molecule-1 (VCAM-1), E-selectin, tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), interleukin-1beta (IL-1beta), and IL-6 in HUVECs.	LC15-0444	13-24	interleukin 1 beta	Homo sapiens	254-271
25823818-3	2015	Using human SW1353, HS.819.T and CH2879 chondrosarcoma cell lines as model systems, we found that fluid shear stress induces the accumulation of cyclic AMP (cAMP) and interleukin-1beta (IL-1beta), which in turn markedly enhance chondrosarcoma cell motility and invasion via the induction of matrix metalloproteinase-7 (MMP-7).	Cyclic AMP	145-155	interleukin 1 beta	Homo sapiens	186-194
25786687-7	2015	Furthermore, CT, mmCT, and dmLT induced IL-1beta production and caspase-1 activation in monocytes, which was associated with increased expression of key proinflammatory and inflammasome-related genes, including NLRP1, NLRP3, and NLRC4.	dmlt	27-31	interleukin 1 beta	Homo sapiens	40-48
25712126-12	2015	Overall, the IL1alpha/IL1R/MYD88/IL6 pathway may be responsible for the reduced antitumor efficacy of erlotinib and other EGFRIs, and blockade of IL1 signaling may improve the efficacy of EGFRIs in the treatment of HNSCC.	Erlotinib Hydrochloride	102-111	interleukin 1 beta	Homo sapiens	13-16
25661535-6	2015	Furthermore, gemigliptin reduced LPS-induced expression of adhesion molecules and inflammatory cytokines such as vascular cell adhesion molecule-1 (VCAM-1), E-selectin, tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), interleukin-1beta (IL-1beta), and IL-6 in HUVECs.	LC15-0444	13-24	interleukin 1 beta	Homo sapiens	273-281
25860871-9	2015	These findings suggest that PGG and PA may block or reduce the entry of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play an important role in interfering with expressions of rhinovirus receptors (intercellular adhesion molecule-1 and low-density lipoprotein receptor), inflammatory cytokines (interleukin (IL)-6, IL-8, tumor necrosis factor, interferon beta, and IL-1beta), and Toll-like receptor, which resulted in diminishing symptoms induced by HRV.	pgg	28-31	interleukin 1 beta	Homo sapiens	433-441
25602689-4	2015	We found the DAQS and CDAI to be highly correlated (r=0.72), and both were inversely associated with levels of IL-1beta (ptrend=0.02 and 0.03, respectively) and TNF-alpha (ptrend=0.005 and 0.003, respectively).	daqs	13-17	interleukin 1 beta	Homo sapiens	111-119
25602689-4	2015	We found the DAQS and CDAI to be highly correlated (r=0.72), and both were inversely associated with levels of IL-1beta (ptrend=0.02 and 0.03, respectively) and TNF-alpha (ptrend=0.005 and 0.003, respectively).	cdai	22-26	interleukin 1 beta	Homo sapiens	111-119
25897296-0	2015	Role of the NLRP3 inflammasome in the transient release of IL-1beta induced by monosodium urate crystals in human fibroblast-like synoviocytes.	Uric Acid	79-95	interleukin 1 beta	Homo sapiens	59-67
25897296-1	2015	BACKGROUND: To investigate whether monosodium urate (MSU) crystals induce interleukin (IL)-1beta in human fibroblast-like synoviocytes (FLS), and whether the NLRP3 inflammasome is involved in the inflammatory mechanism.	Uric Acid	35-51	interleukin 1 beta	Homo sapiens	74-96
25897296-1	2015	BACKGROUND: To investigate whether monosodium urate (MSU) crystals induce interleukin (IL)-1beta in human fibroblast-like synoviocytes (FLS), and whether the NLRP3 inflammasome is involved in the inflammatory mechanism.	Uric Acid	53-56	interleukin 1 beta	Homo sapiens	74-96
25897296-6	2015	Simultaneously, intercellular pro-IL-1beta was detected at 6 h. Furthermore, MSU crystals also induced NLRP3 mRNA and protein expression at 6 h to 48 h after MSU treatment.	Uric Acid	77-80	interleukin 1 beta	Homo sapiens	30-42
25860871-9	2015	These findings suggest that PGG and PA may block or reduce the entry of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play an important role in interfering with expressions of rhinovirus receptors (intercellular adhesion molecule-1 and low-density lipoprotein receptor), inflammatory cytokines (interleukin (IL)-6, IL-8, tumor necrosis factor, interferon beta, and IL-1beta), and Toll-like receptor, which resulted in diminishing symptoms induced by HRV.	paeonol	36-38	interleukin 1 beta	Homo sapiens	433-441
25611805-5	2015	Phlorizin also decreased the expression of UVB-induced pro-inflammatory cytokines, such as interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and interleukin-8 (IL-8) at the mRNA level.	Phlorhizin	0-9	interleukin 1 beta	Homo sapiens	91-109
25853810-0	2015	Nitric oxide sustains IL-1beta expression in human dendritic cells enhancing their capacity to induce IL-17-producing T-cells.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	22-30
25849717-7	2015	Thapsigargin, an ER stress activator, induced upregulated secretion of mature IL-1alpha and IL-1beta in human omental adipose tissue explants primed with bacterial endotoxin LPS, the viral dsRNA analogue poly(I:C) or the pro-inflammatory cytokine TNF-alpha.	Thapsigargin	0-12	interleukin 1 beta	Homo sapiens	92-100
25849717-8	2015	Inhibition of capase-1 with Ac-YVAD-CHO resulted in decreased IL-1alpha and IL-1beta secretion, whereas inhibition of pannexin-1 with carbenoxolone suppressed IL-1beta secretion only.	L 709049	28-39	interleukin 1 beta	Homo sapiens	76-84
25849717-8	2015	Inhibition of capase-1 with Ac-YVAD-CHO resulted in decreased IL-1alpha and IL-1beta secretion, whereas inhibition of pannexin-1 with carbenoxolone suppressed IL-1beta secretion only.	Carbenoxolone	134-147	interleukin 1 beta	Homo sapiens	159-167
25849717-9	2015	Treatment with anti-diabetic drugs metformin and glibenclamide also reduced IL-1alpha and IL-1beta secretion in infection and cytokine-primed adipose tissue.	Metformin	35-44	interleukin 1 beta	Homo sapiens	90-98
25849717-9	2015	Treatment with anti-diabetic drugs metformin and glibenclamide also reduced IL-1alpha and IL-1beta secretion in infection and cytokine-primed adipose tissue.	Glyburide	49-62	interleukin 1 beta	Homo sapiens	90-98
25683465-9	2015	Treatment with IL-1beta enhanced paracellular permeability (4kD dextran) and reduced impedance across the monolayer, which was counteracted by pre-incubation with acetylcholine, or muscarinic receptor agonist bethanechol.	Dextrans	64-71	interleukin 1 beta	Homo sapiens	15-23
25683465-9	2015	Treatment with IL-1beta enhanced paracellular permeability (4kD dextran) and reduced impedance across the monolayer, which was counteracted by pre-incubation with acetylcholine, or muscarinic receptor agonist bethanechol.	Acetylcholine	163-176	interleukin 1 beta	Homo sapiens	15-23
25683465-9	2015	Treatment with IL-1beta enhanced paracellular permeability (4kD dextran) and reduced impedance across the monolayer, which was counteracted by pre-incubation with acetylcholine, or muscarinic receptor agonist bethanechol.	Bethanechol	209-220	interleukin 1 beta	Homo sapiens	15-23
25180620-4	2015	hASMCs obtained from nonasthmatic and asthmatic human subjects were treated with cytomix (IL-1beta, TNF-alpha, and IFN-gamma).	cytomix	81-88	interleukin 1 beta	Homo sapiens	90-98
25394884-5	2015	RESULTS: Increasing concentrations of glucose significantly increased trophoblast secretion of the inflammatory cytokines/chemokines: IL-1beta, IL-6, IL-8, GRO-alpha, RANTES, and G-CSF; significantly increased trophoblast secretion of the anti-angiogenic factors sFlt-1 and sEndoglin; and significantly decreased trophoblast migration.	Glucose	38-45	interleukin 1 beta	Homo sapiens	134-142
25394884-6	2015	Excess glucose-induced trophoblast IL-1beta production was inhibited by disabling the Nalp3/ASC inflammasome.	Glucose	7-14	interleukin 1 beta	Homo sapiens	35-43
25216946-9	2015	Moreover, the transcripts of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha), which are related to atherosclerosis, were up-regulated by TCDD stimulation.	Polychlorinated Dibenzodioxins	162-166	interleukin 1 beta	Homo sapiens	29-47
25216946-9	2015	Moreover, the transcripts of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha), which are related to atherosclerosis, were up-regulated by TCDD stimulation.	Polychlorinated Dibenzodioxins	162-166	interleukin 1 beta	Homo sapiens	49-57
25937780-9	2015	Higher mRNA and supernate secretion levels of IL-1beta, IL-6 and IL-8 were detected in SPC-A1 after being cocultured with TAMs.	tams	122-126	interleukin 1 beta	Homo sapiens	46-54
25937780-13	2015	CONCLUSIONS: These findings demonstrated that TAMs may enhance IL-1beta, IL-6 and IL-8 expressions via TLRs signaling pathway.	tams	46-50	interleukin 1 beta	Homo sapiens	63-71
25611805-5	2015	Phlorizin also decreased the expression of UVB-induced pro-inflammatory cytokines, such as interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and interleukin-8 (IL-8) at the mRNA level.	Phlorhizin	0-9	interleukin 1 beta	Homo sapiens	111-119
25701505-4	2015	Treatment of LPS-stimulated macrophages with 70kGy gamma-irradiated resveratrol resulted in a dose-dependent decrease in iNOS-mediated NO, PGE2, and pro-inflammatory cytokine level, such as TNF-alpha, IL-6 and IL-1beta.	Resveratrol	68-79	interleukin 1 beta	Homo sapiens	210-218
25519802-0	2015	Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1beta in human corneal fibroblasts.	dehydroxymethylepoxyquinomicin	0-30	interleukin 1 beta	Homo sapiens	136-144
25519802-8	2015	DHMEQ significantly suppressed the production of both IL-8 and MCP-1 in IL-1beta-stimulated HCFs.	dehydroxymethylepoxyquinomicin	0-5	interleukin 1 beta	Homo sapiens	72-80
25519802-9	2015	In addition, DHMEQ down-regulated ICAM-1 expression in IL-1beta-stimulated HCFs in a dose-dependent manner.	dehydroxymethylepoxyquinomicin	13-18	interleukin 1 beta	Homo sapiens	55-63
25519802-10	2015	DHMEQ inhibited the IL-1beta-induced nuclear accumulation of p65, a component of NF-kappaB, in HCFs.	dehydroxymethylepoxyquinomicin	0-5	interleukin 1 beta	Homo sapiens	20-28
25708600-6	2015	RESULTS: Niclosamide reduced the secretion of IL-1beta, IL-6, IL-8, IL-17A and IFN-gamma from TNF-alpha-induced RA FLS in a dose-dependent manner.	Niclosamide	9-20	interleukin 1 beta	Homo sapiens	46-54
25693597-0	2015	Hyaluronan suppresses mechanical stress-induced expression of catabolic enzymes by human chondrocytes via inhibition of IL-1beta production and subsequent NF-kappaB activation.	Hyaluronic Acid	0-10	interleukin 1 beta	Homo sapiens	120-128
25749497-12	2015	In vitro studies revealed that Thal decreased 1) the expression of IL-1beta and IL-6 in human lung epithelial cells, and 2) CSE-induced apoptosis and the inhibition of cell growth, which may be the underlying mechanisms for the preventative effects of Thal on emphysema.	Thalidomide	31-35	interleukin 1 beta	Homo sapiens	67-75
25204733-3	2015	In this study, we showed that increased pro-IL-1beta expression was associated with the severity of oral malignant transformation in a mouse OSCC model induced by 4-Nitroquinolin-1-oxide (4-NQO) and arecoline, two carcinogens related to tobacco and betel quid, respectively.	4-Nitroquinoline-1-oxide	163-186	interleukin 1 beta	Homo sapiens	44-52
24934473-2	2015	Genistein modified PES/PVP membranes reveal significant reduction of the reactive oxygen species and also considerable suppression of interleukin-1beta and tumor necrosis factor-alpha levels in whole blood, but to a lesser extent ininterleukin-6.	Genistein	0-9	interleukin 1 beta	Homo sapiens	134-183
24934473-2	2015	Genistein modified PES/PVP membranes reveal significant reduction of the reactive oxygen species and also considerable suppression of interleukin-1beta and tumor necrosis factor-alpha levels in whole blood, but to a lesser extent ininterleukin-6.	Povidone	23-26	interleukin 1 beta	Homo sapiens	134-183
25216359-0	2015	Involvement of intracellular signaling in the IL-1beta inhibitory effect on fructose intestinal absorption.	Fructose	76-84	interleukin 1 beta	Homo sapiens	46-54
26122215-4	2015	Deficiency of vitamin B1 may cause beriberi, dysfunction of the nervous system, neuroinflammation, T cell infiltration, chemokine CCL2 activation, over expression of proinflammatory cytokines, such as IL-1, TNF, IL-6, and arachidonic acid products, and induces expression of CD40 by the microglia and CD40L by astrocytes which provoke the death of neurons.	Thiamine	14-24	interleukin 1 beta	Homo sapiens	201-205
25204733-3	2015	In this study, we showed that increased pro-IL-1beta expression was associated with the severity of oral malignant transformation in a mouse OSCC model induced by 4-Nitroquinolin-1-oxide (4-NQO) and arecoline, two carcinogens related to tobacco and betel quid, respectively.	4-Nitroquinoline-1-oxide	188-193	interleukin 1 beta	Homo sapiens	44-52
25204733-3	2015	In this study, we showed that increased pro-IL-1beta expression was associated with the severity of oral malignant transformation in a mouse OSCC model induced by 4-Nitroquinolin-1-oxide (4-NQO) and arecoline, two carcinogens related to tobacco and betel quid, respectively.	Arecoline	199-208	interleukin 1 beta	Homo sapiens	44-52
25204733-5	2015	In a human OSCC cell line TW2.6, we demonstrated nicotine-derived nitrosamine ketone (NNK) and arecoline stimulated IL-1beta secretion in an inflammasome-dependent manner.	Nicotine	49-57	interleukin 1 beta	Homo sapiens	116-124
25204733-5	2015	In a human OSCC cell line TW2.6, we demonstrated nicotine-derived nitrosamine ketone (NNK) and arecoline stimulated IL-1beta secretion in an inflammasome-dependent manner.	Arecoline	95-104	interleukin 1 beta	Homo sapiens	116-124
25673294-7	2015	We then showed that PLB-Ect down-regulated NiSO4-induced moDC maturation, as witnessed by decreased expression of CD40, CD80, CD83, CD86, PDL-1, and HLA-DR and by decreased levels of IL-1beta, IL-6, TNF-alpha, and IL-12p40 mRNAs.	nickel sulfate	43-48	interleukin 1 beta	Homo sapiens	183-191
24815722-11	2015	RESULTS: The secretion of IL-1beta, TNF-alpha and IL-6 by THP-1 cells was greater in the presence of G-alb than in the presence of N-alb.	n-alb	131-136	interleukin 1 beta	Homo sapiens	26-34
25807407-7	2015	RESULTS: Ketamine treatment dose-dependently attenuated the increased levels of proinflammatory mediators (HMGB1, nitric oxide, tumor necrosis factor alpha, and interleukin 1beta) and increased the HO-1 protein expression in LPS-activated macrophages.	Ketamine	9-17	interleukin 1 beta	Homo sapiens	161-178
25555350-8	2015	In contrast, (PEG+PVA)-NH2 and PVA-NH2 AuNPs were internalized to a higher extent and caused interleukin-1beta secretion.	Polyethylene Glycols	14-17	interleukin 1 beta	Homo sapiens	93-110
25240611-9	2015	CONCLUSION: The cleaved form of IL-1beta is a valuable biomarker for monitoring disease activity and response to colchicine treatment in patients with FMF.	Colchicine	113-123	interleukin 1 beta	Homo sapiens	32-40
25595138-7	2015	Atorvastatin significantly reduced sputum concentrations of CCL7, IL-12p70, sCD40L, FGF-2, CCL4, TGF-alpha and MMP-8 compared with placebo and, when combined with inhaled beclometasone, reduced sputum concentrations of MMP-8, IL-1beta, IL-10, MMP-9, sCD40L, FGF-2, IL-7, G-CSF and CCL7 compared to ICS alone.	Atorvastatin	0-12	interleukin 1 beta	Homo sapiens	226-234
25125502-6	2015	Multiple regression models controlling for age, gender, and grade point average revealed a negative relationship between PSS and GCS for vaccine-stimulated production of IL-1beta, IL-6, and TNF-alpha.	pss	121-124	interleukin 1 beta	Homo sapiens	170-178
25938142-0	2015	[Effect of IL-1beta on inflammatory factors synthesis of human gingival fibroblasts attached to different titaniums].	Titanium	106-115	interleukin 1 beta	Homo sapiens	11-19
25938142-1	2015	PURPOSE: To evaluate the effects of IL-1beta on inflammatory factors synthesis of human gingival fibroblasts on different surfaces of titaniums in vitro.	Titanium	134-143	interleukin 1 beta	Homo sapiens	36-44
25660662-4	2015	The results show that production of IL-1beta, IL-6 and IL-8 was significantly higher in the group of methadone-maintained patients than in the healthy control group.	Methadone	101-110	interleukin 1 beta	Homo sapiens	36-44
26281599-10	2015	The most interesting finding of this study was that the anti-inflammatory effect of flavonoid compounds may be partly attributable to inhibite FOS, PTGS2 expression, inhibite of IL-1beta release, and block the MAPK pathway and toll-like receptor pathway.	Flavonoids	84-93	interleukin 1 beta	Homo sapiens	178-186
25596942-6	2015	These effects of DHA were directly linked with suppression of nuclear factor-kappa B (NFkappaB) activity, as evident by the reduction of p-IkappaBalpha expression, p-NFkappaB p65 nucleus translocation, NFkappaB DNA binding activity, and the regulation of gene transcription (TNFalpha, IL-1beta, ICAM-1, and RAGE mRNA).	Docosahexaenoic Acids	17-20	interleukin 1 beta	Homo sapiens	285-293
25825396-10	2015	Finally, muramyl dipeptide stimulates proinflammatory cytokine interleukin-1beta maturation and accumulation in human and mouse platelets NOD2 dependently.	Acetylmuramyl-Alanyl-Isoglutamine	9-26	interleukin 1 beta	Homo sapiens	63-80
25660662-5	2015	Plasma TNF-alpha and IL-6 levels were significantly correlated with the dairy methadone dosage administered, and the IL-1beta level was significantly correlated with the duration of methadone maintenance treatment.	Methadone	182-191	interleukin 1 beta	Homo sapiens	117-125
25646681-6	2015	In vitro screening showed that AP- and PD-SWCNTs, irrespective of the method of synthesis, as well as graphene (BSA) and GO (S and L) could trigger interleukin-1beta (IL-1beta) and transforming growth factor-beta1 (TGF-beta1) production in myeloid (THP-1) and epithelial (BEAS-2B) cell lines, respectively.	Graphite	102-110	interleukin 1 beta	Homo sapiens	148-165
25806956-0	2015	Correction: olmesartan decreased levels of IL-1beta and TNF-alpha, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model.	olmesartan	12-22	interleukin 1 beta	Homo sapiens	43-51
25646681-6	2015	In vitro screening showed that AP- and PD-SWCNTs, irrespective of the method of synthesis, as well as graphene (BSA) and GO (S and L) could trigger interleukin-1beta (IL-1beta) and transforming growth factor-beta1 (TGF-beta1) production in myeloid (THP-1) and epithelial (BEAS-2B) cell lines, respectively.	Graphite	102-110	interleukin 1 beta	Homo sapiens	167-175
25800347-2	2015	We present evidence that macrophage secretion of IL1beta upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine dehydrogenase, resulting in the formation of uric acid as well as ROS.	Adenosine Triphosphate	79-82	interleukin 1 beta	Homo sapiens	49-56
25799427-8	2015	The combination of the three compounds was significantly more efficient to inhibit interleukin-1beta stimulated matrix metalloproteinase-3 expression than curcuminoids extract alone.	curcuminoids	155-167	interleukin 1 beta	Homo sapiens	83-100
25800347-2	2015	We present evidence that macrophage secretion of IL1beta upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine dehydrogenase, resulting in the formation of uric acid as well as ROS.	Uric Acid	249-258	interleukin 1 beta	Homo sapiens	49-56
25800347-2	2015	We present evidence that macrophage secretion of IL1beta upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine dehydrogenase, resulting in the formation of uric acid as well as ROS.	Reactive Oxygen Species	270-273	interleukin 1 beta	Homo sapiens	49-56
25800347-3	2015	We show that XO-derived ROS, but not uric acid, is the trigger for IL1beta release and that XO blockade results in impaired IL1beta and caspase1 secretion.	Reactive Oxygen Species	24-27	interleukin 1 beta	Homo sapiens	67-74
25803040-6	2015	Pretreatment with urantide, which is a UT receptor antagonist, significantly inhibited the LPS-stimulated expression and release of UII/UT, TNF-alpha, and IL-1beta by KCs.	urotensin II (4-11), Pen(5)-Trp(7)-Orn(8)-	18-26	interleukin 1 beta	Homo sapiens	155-163
25799427-9	2015	In interleukin-1beta-stimulated human chondrocytes, nitric oxide, interleukin-6 and matrix metalloproteinase 3 productions were significantly reduced by curcuminoids extract alone or in combination with hydrolyzed collagen and green tea extract.	Nitric Oxide	52-64	interleukin 1 beta	Homo sapiens	3-20
25799427-9	2015	In interleukin-1beta-stimulated human chondrocytes, nitric oxide, interleukin-6 and matrix metalloproteinase 3 productions were significantly reduced by curcuminoids extract alone or in combination with hydrolyzed collagen and green tea extract.	curcuminoids	153-165	interleukin 1 beta	Homo sapiens	3-20
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	wogonoside	13-23	interleukin 1 beta	Homo sapiens	120-132
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	146-171	interleukin 1 beta	Homo sapiens	120-132
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	wogonoside	13-23	interleukin 1 beta	Homo sapiens	57-65
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	173-176	interleukin 1 beta	Homo sapiens	120-132
25976054-4	2015	RESULTS: A dose of 2.5 microg/L IL-1beta induced the protein expressions of cPLA2 and COX-2 and a subsequent release of PGE2 in a time-dependent manner.	Dinoprostone	120-124	interleukin 1 beta	Homo sapiens	32-40
25430780-8	2015	To provide further support for the role of IL-1beta in the development of SEFL, we show that systemic morphine, a treatment which is known to reduce both PTSD and SEFL, also reduces IL-1beta expression in the DH induced by the severe stressor.	sefl	74-78	interleukin 1 beta	Homo sapiens	43-51
25430780-8	2015	To provide further support for the role of IL-1beta in the development of SEFL, we show that systemic morphine, a treatment which is known to reduce both PTSD and SEFL, also reduces IL-1beta expression in the DH induced by the severe stressor.	sefl	74-78	interleukin 1 beta	Homo sapiens	182-190
25430780-8	2015	To provide further support for the role of IL-1beta in the development of SEFL, we show that systemic morphine, a treatment which is known to reduce both PTSD and SEFL, also reduces IL-1beta expression in the DH induced by the severe stressor.	Morphine	102-110	interleukin 1 beta	Homo sapiens	43-51
25430780-8	2015	To provide further support for the role of IL-1beta in the development of SEFL, we show that systemic morphine, a treatment which is known to reduce both PTSD and SEFL, also reduces IL-1beta expression in the DH induced by the severe stressor.	Morphine	102-110	interleukin 1 beta	Homo sapiens	182-190
25976054-7	2015	Both SB203580 and PD98059 inhibitors reduced IL-1beta-induced PGE2 production while SB203580 alone reduced the expressions of both cPLA2 and COX-2.	SB 203580	5-13	interleukin 1 beta	Homo sapiens	45-53
25976054-7	2015	Both SB203580 and PD98059 inhibitors reduced IL-1beta-induced PGE2 production while SB203580 alone reduced the expressions of both cPLA2 and COX-2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	interleukin 1 beta	Homo sapiens	45-53
25976054-7	2015	Both SB203580 and PD98059 inhibitors reduced IL-1beta-induced PGE2 production while SB203580 alone reduced the expressions of both cPLA2 and COX-2.	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	45-53
25976054-8	2015	CONCLUSION: IL-1beta induces the expressions of cPLA2 and COX-2 and affects COX-2 at the post-translational level by modulating PGE2 production through the signal transduction pathways of p38 and p42/44 MAPKs.	Dinoprostone	128-132	interleukin 1 beta	Homo sapiens	12-20
25652235-5	2015	Diacerein, a semi-synthetic anthraquinone derivative, inhibits the interleukin-1-beta (IL-1beta) cytokine which, according to animal studies, plays a key role in the pathogenesis of OA.	diacerein	0-9	interleukin 1 beta	Homo sapiens	67-85
25622554-3	2015	At non-cytotoxic concentrations, myrcene and limonene inhibited IL-1beta-induced nitric oxide production (IC50=37.3mug/ml and 85.3microg/ml, respectively), but E-caryophyllene was inactive.	myrcene	33-40	interleukin 1 beta	Homo sapiens	64-72
25622554-3	2015	At non-cytotoxic concentrations, myrcene and limonene inhibited IL-1beta-induced nitric oxide production (IC50=37.3mug/ml and 85.3microg/ml, respectively), but E-caryophyllene was inactive.	Limonene	45-53	interleukin 1 beta	Homo sapiens	64-72
25622554-3	2015	At non-cytotoxic concentrations, myrcene and limonene inhibited IL-1beta-induced nitric oxide production (IC50=37.3mug/ml and 85.3microg/ml, respectively), but E-caryophyllene was inactive.	Nitric Oxide	81-93	interleukin 1 beta	Homo sapiens	64-72
25622554-4	2015	Myrcene, and limonene to a lesser extent, also decreased IL-1beta-induced NF-kappaB, JNK and p38 activation and the expression of inflammatory (iNOS) and catabolic (MMP-1 and MMP-13) genes, while increasing the expression of anti-catabolic genes (TIMP-1 and -3 by myrcene and TIMP-1 by limonene).	myrcene	0-7	interleukin 1 beta	Homo sapiens	57-65
25622554-4	2015	Myrcene, and limonene to a lesser extent, also decreased IL-1beta-induced NF-kappaB, JNK and p38 activation and the expression of inflammatory (iNOS) and catabolic (MMP-1 and MMP-13) genes, while increasing the expression of anti-catabolic genes (TIMP-1 and -3 by myrcene and TIMP-1 by limonene).	Limonene	13-21	interleukin 1 beta	Homo sapiens	57-65
25622554-4	2015	Myrcene, and limonene to a lesser extent, also decreased IL-1beta-induced NF-kappaB, JNK and p38 activation and the expression of inflammatory (iNOS) and catabolic (MMP-1 and MMP-13) genes, while increasing the expression of anti-catabolic genes (TIMP-1 and -3 by myrcene and TIMP-1 by limonene).	myrcene	264-271	interleukin 1 beta	Homo sapiens	57-65
25622554-4	2015	Myrcene, and limonene to a lesser extent, also decreased IL-1beta-induced NF-kappaB, JNK and p38 activation and the expression of inflammatory (iNOS) and catabolic (MMP-1 and MMP-13) genes, while increasing the expression of anti-catabolic genes (TIMP-1 and -3 by myrcene and TIMP-1 by limonene).	Limonene	286-294	interleukin 1 beta	Homo sapiens	57-65
25586177-5	2015	Treatment of rat primary beta cells, as well as rat or human whole islets, with 0.1 ng/ml IL-1beta for 2 h increased glucose-stimulated (but not basal) insulin secretion, whereas 20 ng/ml was without effect.	Glucose	117-124	interleukin 1 beta	Homo sapiens	90-98
25730877-5	2015	In CAPS monocytes, LPS induces the externalization of copious amounts of ATP (10-fold), which drive IL-1beta, IL-18, and IL-1alpha release via activation of the P2X purinoceptor 7.	Adenosine Triphosphate	73-76	interleukin 1 beta	Homo sapiens	100-108
25652235-5	2015	Diacerein, a semi-synthetic anthraquinone derivative, inhibits the interleukin-1-beta (IL-1beta) cytokine which, according to animal studies, plays a key role in the pathogenesis of OA.	diacerein	0-9	interleukin 1 beta	Homo sapiens	87-95
25652235-5	2015	Diacerein, a semi-synthetic anthraquinone derivative, inhibits the interleukin-1-beta (IL-1beta) cytokine which, according to animal studies, plays a key role in the pathogenesis of OA.	Anthraquinones	28-41	interleukin 1 beta	Homo sapiens	67-85
25652235-5	2015	Diacerein, a semi-synthetic anthraquinone derivative, inhibits the interleukin-1-beta (IL-1beta) cytokine which, according to animal studies, plays a key role in the pathogenesis of OA.	Anthraquinones	28-41	interleukin 1 beta	Homo sapiens	87-95
24847951-6	2015	EGCG also prevented IL-1beta-mediated VEGF production.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	20-28
25666878-9	2015	Serum lipid peroxidation, luteinizing hormone, testosterone, insulin, interleukin-1 beta, and homocysteine levels were decreased by NAC treatment although serum vitamin A, beta-carotene, vitamin E, and total antioxidant status were increased by the NAC treatment.	Acetylcysteine	132-135	interleukin 1 beta	Homo sapiens	70-88
25547897-7	2015	Hcy exposure also significantly increased the mRNA levels of tumor necrosis factor alpha, interleukin (IL)-6, and IL-1beta, as well as the level of Hcy-inducible endoplasmic reticulum (ER) stress protein, a marker of ER stress, in Hcy-exposed cultures compared with controls.	Homocysteine	0-3	interleukin 1 beta	Homo sapiens	114-122
24847951-8	2015	In addition, the catechins attenuated COX-2 expression induced by LPS and IL-1beta.	Catechin	17-26	interleukin 1 beta	Homo sapiens	74-82
24766418-7	2015	Additionally, glutamine suppressed the production and mRNA expression of inflammatory cytokines including interleukin-1beta (IL-1beta), TNF-alpha, and IL-8.	Glutamine	14-23	interleukin 1 beta	Homo sapiens	106-123
24847951-9	2015	CONCLUSIONS: The up-regulated VEGF and COX-2 expressions in the HDPC stimulated with these bacteria-derived factors or IL-1beta were diminished by the treatment of EGCG and ECG.	epigallocatechin gallate	164-168	interleukin 1 beta	Homo sapiens	119-127
24766418-7	2015	Additionally, glutamine suppressed the production and mRNA expression of inflammatory cytokines including interleukin-1beta (IL-1beta), TNF-alpha, and IL-8.	Glutamine	14-23	interleukin 1 beta	Homo sapiens	125-133
25637445-6	2015	We found that astragalin dose-dependently inhibited IL-1beta-induced NO and PGE2 production, as well as iNOS and COX-2 expression.	Dinoprostone	76-80	interleukin 1 beta	Homo sapiens	52-60
24847951-9	2015	CONCLUSIONS: The up-regulated VEGF and COX-2 expressions in the HDPC stimulated with these bacteria-derived factors or IL-1beta were diminished by the treatment of EGCG and ECG.	epicatechin gallate	173-176	interleukin 1 beta	Homo sapiens	119-127
25593314-5	2015	Also, AgNP15 induced pyroptosis and activation of the NLRP-3 inflammasome as demonstrated by the processing and increased activity of caspase-1 and secretion of IL-1beta and ASC (apoptosis-associated speck-like protein containing a CARD domain) pyroptosome formation.	agnp15	6-12	interleukin 1 beta	Homo sapiens	161-169
25637445-7	2015	Meanwhile, western blot analysis showed that astragalin inhibited IL-1beta-induced NF-kappaB and MAPK activation in human osteoarthritis chondrocyte.	astragalin	45-55	interleukin 1 beta	Homo sapiens	66-74
25637445-9	2015	The inhibition of astragalin on IL-1beta-induced NO and PGE2 production can be reversed by PPAR-gamma antagonist GW9662.	Dinoprostone	56-60	interleukin 1 beta	Homo sapiens	32-40
25637445-9	2015	The inhibition of astragalin on IL-1beta-induced NO and PGE2 production can be reversed by PPAR-gamma antagonist GW9662.	2-chloro-5-nitrobenzanilide	113-119	interleukin 1 beta	Homo sapiens	32-40
25201247-6	2015	UFAs dose-dependently inhibited the increase in IL-1beta secretion and decrease in IL-1Ra secretion induced by Pal.	Fatty Acids, Unsaturated	0-4	interleukin 1 beta	Homo sapiens	48-56
25499441-6	2015	Mangiferin treatment attenuated the expressions of TXNIP and NLRP3 and reduced IL-1beta and IL-6 production, demonstrating its inhibitory effects on TXNIP/NLRP3 inflammasome activation.	mangiferin	0-10	interleukin 1 beta	Homo sapiens	79-87
25686106-9	2015	BHB reduces NLRP3 inflammasome-mediated interleukin (IL)-1beta and IL-18 production in human monocytes.	3-Hydroxybutyric Acid	0-3	interleukin 1 beta	Homo sapiens	40-62
25898559-8	2015	RESULTS: DP-M&amp;O decreased the levels of TNF-alpha, IL-1beta, IL-6, and IL-8 and increased that of IL-10 in a concentration-dependent manner.	3-(3,5-dichlorophenyl)-1-methyl-2,5-pyrrolidinedione	9-13	interleukin 1 beta	Homo sapiens	55-63
25898559-8	2015	RESULTS: DP-M&amp;O decreased the levels of TNF-alpha, IL-1beta, IL-6, and IL-8 and increased that of IL-10 in a concentration-dependent manner.	Adenosine Monophosphate	14-17	interleukin 1 beta	Homo sapiens	55-63
25544568-9	2015	Inhibition of STAT3 activity by JSI124 reduced the expression of p65 and IL-1.	cucurbitacin I	32-38	interleukin 1 beta	Homo sapiens	73-77
25528597-3	2015	Recent studies suggested that IL-1beta production in patients with Mycobacteria tuberculosis infection correlates with inflammasome activation which may be regulated by ROS production in the immune cells.	Reactive Oxygen Species	169-172	interleukin 1 beta	Homo sapiens	30-38
25528597-7	2015	Moreover, macrophages with defective ROS production had poor IL-1beta production and ineffective control of mycobacteria growth.	Reactive Oxygen Species	37-40	interleukin 1 beta	Homo sapiens	61-69
25339289-6	2015	Published studies have shown that some lichen polysaccharides enhance production of nitrous oxide (NO) by macrophages and also alter the production levels of various proinflammatory and antiinflammatory cytokines (IL-10, IL-12, IL-1beta, TNF-alpha, and IFN-alpha/beta) by macrophages and dendritic cells.	lichen polysaccharides	39-61	interleukin 1 beta	Homo sapiens	228-236
25041143-7	2015	Among many other potential actions, IL-1beta increases cyclooxygenase-2 expression leading to local increases in inflammatory mediators such as prostaglandin E2 (PGE2).	Dinoprostone	144-160	interleukin 1 beta	Homo sapiens	36-44
25688664-5	2015	Sulfasalazine dose-dependently inhibited tumor necrosis factor alpha, interleukin 1 (IL-1) beta, IL-2, IL-6, interferon gamma (IFNgamma), and various chemotactic cytokines from SEB-stimulated human PBMC.	Sulfasalazine	0-13	interleukin 1 beta	Homo sapiens	85-95
25729382-0	2015	ATP-Induced IL-1beta Specific Secretion: True Under Stringent Conditions.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	12-20
25729382-4	2015	Subsequently, adenosine triphosphate (ATP) is added to the cells in order to trigger the P2X7 receptor resulting in processing and secretion of mature IL-1beta.	Adenosine Triphosphate	14-36	interleukin 1 beta	Homo sapiens	151-159
25729382-4	2015	Subsequently, adenosine triphosphate (ATP) is added to the cells in order to trigger the P2X7 receptor resulting in processing and secretion of mature IL-1beta.	Adenosine Triphosphate	38-41	interleukin 1 beta	Homo sapiens	151-159
25654762-5	2015	Interestingly, IL-1beta secretion in response to nanoparticles is increased by enhanced ATP and ADP hydrolysis, whereas it is decreased by adenosine degradation or selective A2A or A2B receptor inhibition.	Adenosine Triphosphate	88-91	interleukin 1 beta	Homo sapiens	15-23
25654762-5	2015	Interestingly, IL-1beta secretion in response to nanoparticles is increased by enhanced ATP and ADP hydrolysis, whereas it is decreased by adenosine degradation or selective A2A or A2B receptor inhibition.	Adenosine Diphosphate	96-99	interleukin 1 beta	Homo sapiens	15-23
25654762-5	2015	Interestingly, IL-1beta secretion in response to nanoparticles is increased by enhanced ATP and ADP hydrolysis, whereas it is decreased by adenosine degradation or selective A2A or A2B receptor inhibition.	Adenosine	139-148	interleukin 1 beta	Homo sapiens	15-23
25654762-7	2015	Finally, a high dose of adenosine triggers inflammasome activation and IL-1beta secretion through adenosine cellular uptake by nucleotide transporters and by its subsequent transformation in ATP by adenosine kinase.	Adenosine	24-33	interleukin 1 beta	Homo sapiens	71-79
25654762-7	2015	Finally, a high dose of adenosine triggers inflammasome activation and IL-1beta secretion through adenosine cellular uptake by nucleotide transporters and by its subsequent transformation in ATP by adenosine kinase.	Adenosine	98-107	interleukin 1 beta	Homo sapiens	71-79
25654762-7	2015	Finally, a high dose of adenosine triggers inflammasome activation and IL-1beta secretion through adenosine cellular uptake by nucleotide transporters and by its subsequent transformation in ATP by adenosine kinase.	Adenosine Triphosphate	191-194	interleukin 1 beta	Homo sapiens	71-79
25667511-6	2015	After induction by IL-1beta, calcitriol inhibited the COX-2 protein, as well as its mRNA expression significantly in OVCAR-3 and SKOV-3 cells.	Calcitriol	29-39	interleukin 1 beta	Homo sapiens	19-27
25231464-9	2015	The mechanism of SAA-triggered NLRP3 activation and subsequent IL-1beta secretion was found to involve the generation of reactive oxygen species.	Reactive Oxygen Species	121-144	interleukin 1 beta	Homo sapiens	63-71
25820556-8	2015	The purpose of this study was to investigate the effect of DHEA, a sex hormone, on the expression of lumican and fibromodulin in human temporomandibular specimens and in cultured human TMJ fibroblast-like synovial cells in the presence or absence of the pro-inflammatory cytokine interleukin-1beta (IL-1beta).	Dehydroepiandrosterone	59-63	interleukin 1 beta	Homo sapiens	280-297
25820556-8	2015	The purpose of this study was to investigate the effect of DHEA, a sex hormone, on the expression of lumican and fibromodulin in human temporomandibular specimens and in cultured human TMJ fibroblast-like synovial cells in the presence or absence of the pro-inflammatory cytokine interleukin-1beta (IL-1beta).	Dehydroepiandrosterone	59-63	interleukin 1 beta	Homo sapiens	299-307
25820556-16	2015	These results indicate that DHEA may have a protective effect on synovial tissue in TMJ by enhancing fibromodulin formation after IL-1beta induced inflammation.	Dehydroepiandrosterone	28-32	interleukin 1 beta	Homo sapiens	130-138
25494317-8	2015	RESULTS: NF-kappaB specific inhibitor BAY11-7082 significantly inhibited IL-1beta-induced NF-kappaB activation.	3-(4-methylphenylsulfonyl)-2-propenenitrile	38-48	interleukin 1 beta	Homo sapiens	73-81
25494317-10	2015	The decreased gene expression of aggrecan and type II collagen, induced by IL-1beta was also reversed by BAY11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	105-115	interleukin 1 beta	Homo sapiens	75-83
25678688-0	2015	Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1beta and IL-18.	7-ketocholesterol	25-42	interleukin 1 beta	Homo sapiens	140-148
25760537-4	2015	Formation of alpha-hydroxytriazolam catalyzed by CYP3A was decreased by IL-1beta and IL-6.	alpha-hydroxytriazolam	13-35	interleukin 1 beta	Homo sapiens	72-80
25239226-4	2015	Examination of signaling pathways in human retinal Muller cells (MIO-M1 cell line) cultured with IL-1beta, TNF-alpha, IL-6, IL-8, VEGF, IFN-gamma, glucose or mannitol showed that IL-1beta was the most potent stimulator of IL-6 production.	Mannitol	158-166	interleukin 1 beta	Homo sapiens	179-187
25239226-6	2015	Induction of IL-6 production by IL-1beta was significantly reduced by addition of p38 MAPK (SB203580), MEK1/2 (U0126) or NF-kappaB (BAY11-7082) inhibitors, with the highest effect being observed with SB203580.	SB 203580	92-100	interleukin 1 beta	Homo sapiens	32-40
25239226-6	2015	Induction of IL-6 production by IL-1beta was significantly reduced by addition of p38 MAPK (SB203580), MEK1/2 (U0126) or NF-kappaB (BAY11-7082) inhibitors, with the highest effect being observed with SB203580.	U 0126	111-116	interleukin 1 beta	Homo sapiens	32-40
25239226-6	2015	Induction of IL-6 production by IL-1beta was significantly reduced by addition of p38 MAPK (SB203580), MEK1/2 (U0126) or NF-kappaB (BAY11-7082) inhibitors, with the highest effect being observed with SB203580.	3-(4-methylphenylsulfonyl)-2-propenenitrile	132-142	interleukin 1 beta	Homo sapiens	32-40
25239226-6	2015	Induction of IL-6 production by IL-1beta was significantly reduced by addition of p38 MAPK (SB203580), MEK1/2 (U0126) or NF-kappaB (BAY11-7082) inhibitors, with the highest effect being observed with SB203580.	SB 203580	200-208	interleukin 1 beta	Homo sapiens	32-40
25523440-10	2015	Anti-inflammatory treatment with ibuprofen prevents the increased tumour necrosis factor-alpha and interleukin-1beta levels in the CB and the hypertension, but does not reduce the enhanced chemosensory hypoxic response and the local oxidative stress in the CB.	Ibuprofen	33-42	interleukin 1 beta	Homo sapiens	99-116
25041143-7	2015	Among many other potential actions, IL-1beta increases cyclooxygenase-2 expression leading to local increases in inflammatory mediators such as prostaglandin E2 (PGE2).	Dinoprostone	162-166	interleukin 1 beta	Homo sapiens	36-44
25398638-10	2015	Intracellular iron sequestration was induced by IL1beta and iron and alleviated by beta-carotene.	Iron	14-18	interleukin 1 beta	Homo sapiens	48-55
25172696-6	2015	Furthermore, increases in the mRNA expression of colonic macrophage inflammatory protein 2 and IL-1beta, which were induced by DSS, were significantly suppressed by CHA supplementation.	dss	127-130	interleukin 1 beta	Homo sapiens	95-103
25172696-6	2015	Furthermore, increases in the mRNA expression of colonic macrophage inflammatory protein 2 and IL-1beta, which were induced by DSS, were significantly suppressed by CHA supplementation.	Chlorogenic Acid	165-168	interleukin 1 beta	Homo sapiens	95-103
25059418-7	2015	Treatment with poly(I:C) specifically up-regulated surface expression of co-stimulatory molecules and increased release of IL-12p70 in MoLC and co-stimulation with TNF-alpha and IL-1beta further elevated Th1 and Th17 cytokine production.	Poly I-C	15-23	interleukin 1 beta	Homo sapiens	178-186
25138142-0	2015	Vancomycin blocks autophagy and induces interleukin-1beta release in macrophages.	Vancomycin	0-10	interleukin 1 beta	Homo sapiens	40-57
25576658-3	2015	In this paper we demonstrate that in LPS-stimulated microglia resveratrol pretreatment reduced, in a dose-dependent manner, pro-inflammatory cytokines IL-1beta, TNF-alpha and IL-6 mRNA expression and increased the release of anti-inflammatory interleukin (IL)-10.	Resveratrol	62-73	interleukin 1 beta	Homo sapiens	151-159
25189464-6	2015	Our results showed that kaempferol at concentrations of 12.5 and 25 mug/mL significantly suppressed the release of TNF-alpha, IL-1beta, IL-6, and IL-18 and inhibited activation of NF-kappaB and Akt in LPS plus ATP-induced cardiac fibroblasts.	kaempferol	24-34	interleukin 1 beta	Homo sapiens	126-134
25379992-0	2015	Procyanidin B2 inhibits inflammasome-mediated IL-1beta production in lipopolysaccharide-stimulated macrophages.	procyanidin B2	0-14	interleukin 1 beta	Homo sapiens	46-54
25420918-4	2015	When DC maturation was induced by TLR agonists, reduced cytokine levels (IL-6, IL-1beta, and IL-12p70) were observed in Cl-amidine-treated DCs.	N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide	120-130	interleukin 1 beta	Homo sapiens	79-87
25453750-7	2015	In univariate models, log transformed 25-OHD was significantly and inversely associated with log transformed IL-1beta (p=0.002) and log transformed IL-6 (p=0.032).	25-ohd	38-44	interleukin 1 beta	Homo sapiens	109-117
24753349-4	2015	Silk scaffolds prepared using the organic solvent hexafluoroisopropanol as compared to an aqueous-based method, as well as those with larger pore sizes, supported the deposition of higher cartilage matrix levels and lower expression of cartilage matrix degradation-related genes, as well as lower expression of endogenous proinflammatory cytokines IL-1beta in articular chondrocytes.	hexafluoroisopropanol	50-71	interleukin 1 beta	Homo sapiens	348-356
23828493-6	2015	IL-1beta level in gingival crevicular fluid was higher in SRP group after 1 week (SRP 24.65 +- 18.85 pg/muL/SRP + aPDT 34.07 +- 24.81 pg/muL; p = 0.048), and MMP-8 level was higher in SRP group after 12 weeks (SRP 303.31 +- 331.62 pg/muL/SRP + aPDT 534.23 +- 647.37 pg/muL; p = 0.024).	apdt	114-118	interleukin 1 beta	Homo sapiens	0-8
23828493-6	2015	IL-1beta level in gingival crevicular fluid was higher in SRP group after 1 week (SRP 24.65 +- 18.85 pg/muL/SRP + aPDT 34.07 +- 24.81 pg/muL; p = 0.048), and MMP-8 level was higher in SRP group after 12 weeks (SRP 303.31 +- 331.62 pg/muL/SRP + aPDT 534.23 +- 647.37 pg/muL; p = 0.024).	L-seryl-AMP	58-61	interleukin 1 beta	Homo sapiens	0-8
23828493-6	2015	IL-1beta level in gingival crevicular fluid was higher in SRP group after 1 week (SRP 24.65 +- 18.85 pg/muL/SRP + aPDT 34.07 +- 24.81 pg/muL; p = 0.048), and MMP-8 level was higher in SRP group after 12 weeks (SRP 303.31 +- 331.62 pg/muL/SRP + aPDT 534.23 +- 647.37 pg/muL; p = 0.024).	L-seryl-AMP	82-85	interleukin 1 beta	Homo sapiens	0-8
23828493-6	2015	IL-1beta level in gingival crevicular fluid was higher in SRP group after 1 week (SRP 24.65 +- 18.85 pg/muL/SRP + aPDT 34.07 +- 24.81 pg/muL; p = 0.048), and MMP-8 level was higher in SRP group after 12 weeks (SRP 303.31 +- 331.62 pg/muL/SRP + aPDT 534.23 +- 647.37 pg/muL; p = 0.024).	apdt	244-248	interleukin 1 beta	Homo sapiens	0-8
25374119-5	2015	The results demonstrated that simvastatin suppressed the increased mRNA expression of monocyte chemoattractant protein-1, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 and the content of reactive oxygen species induced by Ang II in a dose-dependent manner.	Simvastatin	30-41	interleukin 1 beta	Homo sapiens	151-173
25379992-7	2015	Furthermore, procyanidin B2 decreases NLRP3 and pro-IL-1beta cytoplasmic pools, limiting components of inflammasome activation and impeding inflammasome assembly and caspase-1 activation, and finally secretion of active IL-1beta.	procyanidin B2	13-27	interleukin 1 beta	Homo sapiens	48-60
25461290-2	2015	We find that high TiO2 concentrations induce the cytokines Interleukin IL-1beta, IL-6, and IL-10 secretion, while at low concentrations only IL-6 secretion is observed.	titanium dioxide	18-22	interleukin 1 beta	Homo sapiens	71-79
25379992-7	2015	Furthermore, procyanidin B2 decreases NLRP3 and pro-IL-1beta cytoplasmic pools, limiting components of inflammasome activation and impeding inflammasome assembly and caspase-1 activation, and finally secretion of active IL-1beta.	procyanidin B2	13-27	interleukin 1 beta	Homo sapiens	52-60
25379992-8	2015	CONCLUSION: This study provides the first evidence that procyanidin B2 inhibits inflammasome activation and IL-1beta secretion during LPS-induced acute inflammation in human macrophages.	procyanidin B2	56-70	interleukin 1 beta	Homo sapiens	108-116
25624376-7	2015	Urine interleukin-1beta level was significantly lower in colostrum group at 2 weeks (55.3 vs 91.8 mug/g creatinine, P = .01).	Creatinine	104-114	interleukin 1 beta	Homo sapiens	6-23
25560571-6	2015	A metformin combination therapy significantly decreased such inflamation parameters as hs-CRP, ox-LDL, TNF-alpha and IL-1beta levels relative to monotherapies.	Metformin	2-11	interleukin 1 beta	Homo sapiens	117-125
25273157-7	2015	Treatment with levosimendan strongly attenuated IL-1beta-induced expression of IL-6 and IL-8 in HACM as well as E-selectin and ICAM-1 in ECs.	Simendan	15-27	interleukin 1 beta	Homo sapiens	48-56
25150176-10	2015	Dexamethasone also prevented induction of SP by IL-1beta and by cyclic mechanical loading.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	48-56
25161312-5	2015	Adenosine triphosphate-stimulated IL-1beta in lipopolysaccharide-primed macrophages was measured via ELISA.	Adenosine Triphosphate	0-22	interleukin 1 beta	Homo sapiens	34-42
25161312-8	2015	RESULTS: ATP-induced IL-1beta production was increased in macrophages of both male and female SLE patients.	Adenosine Triphosphate	9-12	interleukin 1 beta	Homo sapiens	21-29
25310769-15	2015	IL-1alpha and IL-1beta activity was increased in Cisplatin-treated PTs.	Cisplatin	49-58	interleukin 1 beta	Homo sapiens	14-22
25273157-10	2015	Additionally, levosimendan strongly diminished IL-1beta-induced reactive oxygen species and nuclear factor-kappaB (NF-kappaB) activity through inhibition of S536 phosphorylation.	Simendan	14-26	interleukin 1 beta	Homo sapiens	47-55
25273157-10	2015	Additionally, levosimendan strongly diminished IL-1beta-induced reactive oxygen species and nuclear factor-kappaB (NF-kappaB) activity through inhibition of S536 phosphorylation.	Reactive Oxygen Species	64-87	interleukin 1 beta	Homo sapiens	47-55
25451941-2	2015	ITF2357 inhibits both Class I and II HDACs and reduces caspase-1 activity in human peripheral blood mononuclear cells and the secretion of IL-1beta and other cytokines at 25-100 nm; at concentrations &gt;200 nm, ITF2357 is toxic in vitro.	givinostat hydrochloride	0-7	interleukin 1 beta	Homo sapiens	139-147
25134759-9	2015	Expression of IL-1beta mRNA by MNCs was also decreased after 24 hours of treatment with 10 mug/mL of bezafibrate, whereas the IL-1beta level in the culture supernatant was significantly decreased after treatment of MNCs with either 1 or 10 mug/mL of bezafibrate.	Bezafibrate	101-112	interleukin 1 beta	Homo sapiens	14-22
25134759-9	2015	Expression of IL-1beta mRNA by MNCs was also decreased after 24 hours of treatment with 10 mug/mL of bezafibrate, whereas the IL-1beta level in the culture supernatant was significantly decreased after treatment of MNCs with either 1 or 10 mug/mL of bezafibrate.	Bezafibrate	250-261	interleukin 1 beta	Homo sapiens	14-22
25506811-5	2015	All polymers increased the production of interleukins 1 beta and 6 (IL-1beta and IL-6), but the oxovanadium complexes were more potent activators of these mediators.	Polymers	4-12	interleukin 1 beta	Homo sapiens	41-66
25506811-5	2015	All polymers increased the production of interleukins 1 beta and 6 (IL-1beta and IL-6), but the oxovanadium complexes were more potent activators of these mediators.	Polymers	4-12	interleukin 1 beta	Homo sapiens	68-76
25625944-4	2015	Pre-treatment with tumor necrosis factor-alpha (TNF) or interleukin-1beta inhibited dexamethasone-induced mRNA expression of the putative anti-inflammatory genes RGS2 and TSC22D3, or just TSC22D3, in primary human airway epithelial and smooth muscle cells, respectively.	Dexamethasone	84-97	interleukin 1 beta	Homo sapiens	56-73
25626905-9	2015	Finally, we found that IL-1beta was increased in the serum of patients with CDI, suggesting that this systemic response could influence downstream production of pathogenic IL-23.	1,1'-Carbonyldiimidazole	76-79	interleukin 1 beta	Homo sapiens	23-31
25451941-10	2015	Mechanistically, ITF3056 reduced the secretion of processed IL-1beta independent of inhibition of caspase-1 activity; however, synthesis of the IL-1beta precursor was reduced by 40% without significant decrease in IL-1beta mRNA levels.	itf3056	17-24	interleukin 1 beta	Homo sapiens	60-68
25854350-9	2015	PEMF treatment significantly decreased MMP-9 protein levels in human chondrosarcoma cells stimulated with 0.5 ng/ml IL-1beta at day 7, whereas it did not show any effect on cells stimulated with 5 ng/ml IL-1beta.	pemf	0-4	interleukin 1 beta	Homo sapiens	116-124
25449925-5	2015	Chitosan enhanced anabolic factor release from M0 and M2a macrophages (MCP-1, IP-10, MIP-1beta, IL-1ra, IL-10, PDGF), and IL-1beta release, with 25- to 400-fold excess IL-1ra over IL-1beta.	Chitosan	0-8	interleukin 1 beta	Homo sapiens	122-130
25449925-5	2015	Chitosan enhanced anabolic factor release from M0 and M2a macrophages (MCP-1, IP-10, MIP-1beta, IL-1ra, IL-10, PDGF), and IL-1beta release, with 25- to 400-fold excess IL-1ra over IL-1beta.	Chitosan	0-8	interleukin 1 beta	Homo sapiens	180-188
25449925-9	2015	In primary human macrophages, acetylated chitosan enhanced IL-1ra release without inducing IL-1beta, and required PMA priming to elicit STAT-1 activation and IP-10 release.	Chitosan	41-49	interleukin 1 beta	Homo sapiens	91-99
25449925-10	2015	We conclude that biodegradable chitosan particles enhance M0 and M2a macrophage anabolic responses independent of the IL4/STAT-6 axis, by inducing excess IL-1ra over IL-1beta and more chemokine release, without altering their inherent capacity to attract MSCs.	Chitosan	31-39	interleukin 1 beta	Homo sapiens	166-174
25398539-6	2015	MSU crystals promoted ROS, iNOS, and COX-2 expression and also increased TRAF-6 and IL-1beta expression in HEK293 cells, which was inhibited by an antioxidant ascorbic acid.	Ascorbic Acid	159-172	interleukin 1 beta	Homo sapiens	84-92
25398539-7	2015	Caspase-dependent renal cell apoptosis was induced through attenuation of Bcl-2 and enhanced caspase-3 and caspase-9 expression by MSU crystals, which was significantly reversed by ascorbic acid and transfection of IL-1beta siRNA to HEK293 cells.	Uric Acid	131-134	interleukin 1 beta	Homo sapiens	215-223
25398539-9	2015	ROS accumulation and iNOS and COX-2 mRNA expression by MSU crystals was also suppressed by transfection with IL-1beta siRNA.	Reactive Oxygen Species	0-3	interleukin 1 beta	Homo sapiens	109-117
25445724-11	2015	Our observations demonstrate that SNP -130 C/T modulates AhR expression and expression levels of IL-24 and IL-1beta, and suggest an association of AhR SNP -130 C/T with the susceptibility to dioxins.	Dioxins	191-198	interleukin 1 beta	Homo sapiens	107-115
25571780-0	2015	Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta.	gamma-Aminobutyric Acid	46-50	interleukin 1 beta	Homo sapiens	143-161
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Tetradecanoylphorbol Acetate	9-12	interleukin 1 beta	Homo sapiens	186-194
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Ionomycin	15-24	interleukin 1 beta	Homo sapiens	186-194
25854350-9	2015	PEMF treatment significantly decreased MMP-9 protein levels in human chondrosarcoma cells stimulated with 0.5 ng/ml IL-1beta at day 7, whereas it did not show any effect on cells stimulated with 5 ng/ml IL-1beta.	pemf	0-4	interleukin 1 beta	Homo sapiens	203-211
25854350-11	2015	The results of this study showed that PEMF treatment suppressed IL-1beta-mediated upregulation of MMP-9 protein levels in a dual effect manner.	pemf	38-42	interleukin 1 beta	Homo sapiens	64-72
26328492-4	2015	In this study, we investigated whether and how salubrinal affects NF-kappaB activation induced by tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta.	salubrinal	47-57	interleukin 1 beta	Homo sapiens	136-158
25409926-4	2015	We explored whether luteolin, a common flavonoid in many types of plants, may inhibit interleukin (IL)-1beta function induction of the inflammation biomarker cyclooxygenase (COX)-2.	Luteolin	20-28	interleukin 1 beta	Homo sapiens	86-108
24760326-7	2015	Exposure of the cells to MWCNTs or asbestos provoked IL-1beta secretion, but this secretion was suppressed by both Y27632 and Z-YVAD, whereas LPS-induced IL-1beta secretion was inhibited only by Z-YVAD and not by Y27632.	Asbestos	35-43	interleukin 1 beta	Homo sapiens	53-61
24760326-9	2015	Moreover, Y27632 suppressed pro-IL-1beta protein levels and the release of activated-cathepsin B and activated-caspase-1 induced by MWCNTs or asbestos.	Y 27632	10-16	interleukin 1 beta	Homo sapiens	28-40
25868343-2	2015	The effect of different concentrations of the polysaccharide on production of TNF-alpha, IL-1beta and IL-6 was studied.	Polysaccharides	46-60	interleukin 1 beta	Homo sapiens	89-97
25722974-2	2015	Though cytokines, TNF-alpha and IL-1beta, decrease intracellular cyclic AMP, the mechanism by which this occurs is poorly understood.	Cyclic AMP	65-75	interleukin 1 beta	Homo sapiens	32-40
26339621-0	2015	Interleukin-1 beta Modulates Melatonin Secretion in Ovine Pineal Gland: Ex Vivo Study.	Melatonin	29-38	interleukin 1 beta	Homo sapiens	0-18
26339621-6	2015	It was found that IL-1beta abolished (P &lt; 0.05) NE-induced increase in melatonin release.	Melatonin	74-83	interleukin 1 beta	Homo sapiens	18-26
26339621-9	2015	Our study proves that IL-1beta suppresses melatonin secretion and its action seems to be targeted on the reduction of pineal AA-NAT protein expression.	Melatonin	42-51	interleukin 1 beta	Homo sapiens	22-30
25593646-4	2015	Treatment with ciglitazone, a PPARgamma ligand, reduced both IL-1beta-mediated enhancement of Th17 differentiation and activation of Th17 cells after polarization.	ciglitazone	15-26	interleukin 1 beta	Homo sapiens	61-69
24647791-2	2015	IL-1beta stimulates cyclooxygenase-2 (COX-2) expression and prostanoid production of pulp cells and affects the inflammatory and healing processes of the dental pulp.	Prostaglandins	60-70	interleukin 1 beta	Homo sapiens	0-8
26892351-9	2015	Higher baseline PPD values and the presence of BOP on day 180 were significantly associated with higher IL-1beta concentrations.	bop	47-50	interleukin 1 beta	Homo sapiens	104-112
26314949-13	2015	Moreover, with the application of higher free cholesterol concentrations, macrophage apoptosis and secretion of the inflammatory cytokine IL-1beta increased significantly.	Cholesterol	46-57	interleukin 1 beta	Homo sapiens	138-146
25591955-5	2015	Moreover, treatment of macrophages with 15d-PGJ2, a natural PPAR-gamma ligand, significantly reduced Ang II-induced expression of Egr-1 and its inflammatory gene targets (IL-1beta, TNF-alpha, TGF-beta, MCP-1 and ICAM-1) through PPAR-gamma activation and ROS formation.	15-deoxyprostaglandin J2	40-48	interleukin 1 beta	Homo sapiens	171-179
27602595-4	2015	AGEs stimulated production of reactive oxygen species and pro-inflammatory mediators such as tumor necrosis factor-alpha and interleukin-1beta via extracellular-signal-regulated kinases phosphorylation and nuclear factor-kappaB activation in HUVECs.	Reactive Oxygen Species	30-53	interleukin 1 beta	Homo sapiens	125-142
26202361-9	2015	In addition, HER2 kinase inhibitor AG825 or NRG-1 inhibitor TAPI inhibits inflammasome-mediated permeability in A549 cells and HSAEC demonstrating critical roles of IL-1beta, NRG-1, and HER2 in inflammasome-mediated alveolar permeability.	tyrphostin AG825	35-40	interleukin 1 beta	Homo sapiens	165-173
24647791-13	2015	Aspirin and eugenol enhanced the IL-1beta-induced sICAM-1 production and ICAM-1 expression.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	33-41
24647791-13	2015	Aspirin and eugenol enhanced the IL-1beta-induced sICAM-1 production and ICAM-1 expression.	Eugenol	12-19	interleukin 1 beta	Homo sapiens	33-41
24647791-15	2015	LY294002 and U0126 attenuated IL-1beta-induced ICAM-1 expression and sICAM-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Homo sapiens	30-38
24647791-15	2015	LY294002 and U0126 attenuated IL-1beta-induced ICAM-1 expression and sICAM-1 production.	U 0126	13-18	interleukin 1 beta	Homo sapiens	30-38
25394311-4	2015	ANCA-induced reactive oxygen species generation plays an important role in downregulating inflammation by inhibition of the inflammasome-dependent caspase-1 activation and subsequent IL-1beta generation.	Reactive Oxygen Species	13-36	interleukin 1 beta	Homo sapiens	183-191
26238371-6	2015	IL-1beta, IL-6, IL-8 and TNF-alpha production could be significantly upregulated and downregulated by a ROS activator or inhibitor, respectively.	Reactive Oxygen Species	104-107	interleukin 1 beta	Homo sapiens	0-8
25613133-5	2015	In addition, dCA potently inhibits Tat mediated dysregulation of IL-1beta, TNF-alpha and MCP-1, key neuroinflammatory signaling proteins.	didehydro-cortistatin A	13-16	interleukin 1 beta	Homo sapiens	65-73
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Flavonoids	22-31	interleukin 1 beta	Homo sapiens	101-109
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Polyphenols	32-43	interleukin 1 beta	Homo sapiens	101-109
25434759-6	2015	Calcium citrate was furthermore found to significantly inhibit the production of IL-1beta, IL-6, and TNF-alpha in response to LPS-stimulation.	Calcium Citrate	0-15	interleukin 1 beta	Homo sapiens	81-89
26044807-4	2015	In the meningitis/saline group IL-1beta and cytokine-induced neutrophil chemoattractant-1 (CINC-1) levels increased at 24 h post-infection; adjuvant treatment with IL-1Ra reversed the increased levels in the hippocampus.	Sodium Chloride	18-24	interleukin 1 beta	Homo sapiens	31-39
25596480-0	2015	Switch regulation of interleukin-1 beta in downstream of inflammatory cytokines induced by two micro-sized silica particles on differentiated THP-1 macrophages.	Silicon Dioxide	107-113	interleukin 1 beta	Homo sapiens	21-39
25596480-2	2015	Cytotoxicity and inflammatory cytokines (IL-1beta, TNF-alpha and IL-6) expressions measured showed that they were induced by both silica particles in positive dose-dependent manners.	Silicon Dioxide	130-136	interleukin 1 beta	Homo sapiens	41-49
25596480-4	2015	When pretreated with anti-human IL-1beta, not only the high levels of IL-1beta but also elevated TNF-alpha and IL-6 induced by both silica particles were remarkably blocked, especially Si1mum particle.	Silicon Dioxide	132-138	interleukin 1 beta	Homo sapiens	32-40
25596480-4	2015	When pretreated with anti-human IL-1beta, not only the high levels of IL-1beta but also elevated TNF-alpha and IL-6 induced by both silica particles were remarkably blocked, especially Si1mum particle.	Silicon Dioxide	132-138	interleukin 1 beta	Homo sapiens	70-78
25596480-6	2015	Our data suggest that IL-1beta could play a critical role of switching regulation in the downstream inflammation induced by micro-sized silica particles.	Silicon Dioxide	136-142	interleukin 1 beta	Homo sapiens	22-30
26770254-6	2015	The results showed that, after treatment, FYD-CS, while inducing S-phase cell cycle arrest, enhanced cell proliferation and protected the cells against IL-1beta- and/or SB431542-induced cell growth inhibition.	fyd-cs	42-48	interleukin 1 beta	Homo sapiens	152-160
26770254-7	2015	Furthermore, FYD-CS reversed the decreased expression of COL2A1 and SOX9 induced by IL-1beta and SB431542 and blocked the decreased phosphorylation of Smad2/3 induced by IL-1beta alone or in combination with SB431542.	Cesium	17-19	interleukin 1 beta	Homo sapiens	84-92
26770254-7	2015	Furthermore, FYD-CS reversed the decreased expression of COL2A1 and SOX9 induced by IL-1beta and SB431542 and blocked the decreased phosphorylation of Smad2/3 induced by IL-1beta alone or in combination with SB431542.	Cesium	17-19	interleukin 1 beta	Homo sapiens	170-178
26435646-0	2015	Urate crystals induce NLRP3 inflammasome-dependent IL-1beta secretion and proliferation in isolated primary human T-cells.	Uric Acid	0-5	interleukin 1 beta	Homo sapiens	51-59
26136131-8	2015	The impact of simvastatin administered together with fenofibrate on TNF-alpha, interleukin-1beta, and hsCRP was also stronger in the men than in the women, but the difference did not reach the level of significance.	Fenofibrate	53-64	interleukin 1 beta	Homo sapiens	79-96
26121924-5	2015	Peiminine inhibits the production of the pro-inflammatory cytokine, such as interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and IL-1beta (IL-1beta).	peiminine	0-9	interleukin 1 beta	Homo sapiens	146-154
26471424-0	2015	Chlorogenic acid and luteolin synergistically inhibit the proliferation of interleukin-1beta-induced fibroblast-like synoviocytes through regulating the activation of NF-kappaB and JAK/STAT-signaling pathways.	Chlorogenic Acid	0-16	interleukin 1 beta	Homo sapiens	75-92
26471424-0	2015	Chlorogenic acid and luteolin synergistically inhibit the proliferation of interleukin-1beta-induced fibroblast-like synoviocytes through regulating the activation of NF-kappaB and JAK/STAT-signaling pathways.	Luteolin	21-29	interleukin 1 beta	Homo sapiens	75-92
26136131-8	2015	The impact of simvastatin administered together with fenofibrate on TNF-alpha, interleukin-1beta, and hsCRP was also stronger in the men than in the women, but the difference did not reach the level of significance.	Simvastatin	14-25	interleukin 1 beta	Homo sapiens	79-96
25327779-7	2015	Treatment with the antioxidant N-acetylcysteine significantly attenuated protein conversion of interleukin 1beta after hepatic I/R.	Acetylcysteine	31-47	interleukin 1 beta	Homo sapiens	95-112
26121924-5	2015	Peiminine inhibits the production of the pro-inflammatory cytokine, such as interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and IL-1beta (IL-1beta).	peiminine	0-9	interleukin 1 beta	Homo sapiens	156-164
25403801-7	2015	In addition, the high levels of tumor necrosis factor-alpha, interleukin-1beta, and receptor activator of nuclear factor-kappa B ligand (RANKL) expression induced by LPS were inhibited after treatment with atRA.	Tretinoin	206-210	interleukin 1 beta	Homo sapiens	61-78
26451144-10	2015	In vivo and in vitro studies showed a downregulation of NGAL, IL-17, IL-6, IL-1beta, TNF-alpha, and IFN-gamma after paricalcitol administration (p &lt; 0.0001).	paricalcitol	116-128	interleukin 1 beta	Homo sapiens	75-83
26435646-8	2015	RESULTS: Urate induced caspase-1 activation and IL-1beta release by T-cells.	Uric Acid	9-14	interleukin 1 beta	Homo sapiens	48-56
26435646-10	2015	Glyburide inhibited urate-induced caspase-1 activation, IL-1beta secretion and proliferation.	Glyburide	0-9	interleukin 1 beta	Homo sapiens	56-64
26435646-10	2015	Glyburide inhibited urate-induced caspase-1 activation, IL-1beta secretion and proliferation.	Uric Acid	20-25	interleukin 1 beta	Homo sapiens	56-64
25171343-4	2015	The experimental results showed that after spinal cord injury, rapamycin reduced the numbers of activated microglia and neutrophils in the damage zone, lowered the expression levels of TNF-alpha and IL-1beta, reduced the apoptotic cells, and increased the survival of neurons.	Sirolimus	63-72	interleukin 1 beta	Homo sapiens	199-207
26027988-4	2015	The esophageal ulcer, which was intractable to conventional therapy, improved with the administration of 5-aminosalicylate, a drug known to inhibit IL-1beta.	Mesalamine	105-122	interleukin 1 beta	Homo sapiens	148-156
25096614-0	2015	Camptothecin and its analogs reduce amyloid-beta production and amyloid-beta42-induced IL-1beta production.	Camptothecin	0-12	interleukin 1 beta	Homo sapiens	87-95
25764208-0	2015	Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	35-38	interleukin 1 beta	Homo sapiens	166-174
24806275-2	2015	The goal of this study was to investigate the potential for Mn(2+), via its pro-oxidative properties, to activate production of pro-inflammatory cytokines/chemokines IL-1beta, IL-6, IL-8, IFNgamma, TNFalpha, and G-CSF by human monocyte-derived macrophages in vitro.	Manganese(2+)	60-66	interleukin 1 beta	Homo sapiens	166-174
24806275-5	2015	Exposure of the cells to LPS caused modest statistically insignificant increases in cytokine production; MnCl2 caused dose-related increases in production of all six cytokines (achieving statistical significance of p &lt; 0.0171- &lt; 0.0005 for IL-1beta, IL-6, IL-8, IFNgamma, and TNFalpha).	manganese chloride	105-110	interleukin 1 beta	Homo sapiens	246-254
24806275-6	2015	In the case of LPS and MnCl2 combinations, the observed increases in production of IL-1beta, IL-6, IL-8, IFNgamma, and G-CSF were greater than those seen with cells exposed to the individual agents.	manganese chloride	23-28	interleukin 1 beta	Homo sapiens	83-91
24880451-4	2015	RESULTS: standards curves generated with the use of phosphate-buffered saline (PBS) demonstrated best adjustment for cytokines IL-1ss, IL-6 and TNF- alpha levels, when using Tris-HCl (p&lt;0.05).	Phosphate-Buffered Saline	52-77	interleukin 1 beta	Homo sapiens	127-131
24880451-4	2015	RESULTS: standards curves generated with the use of phosphate-buffered saline (PBS) demonstrated best adjustment for cytokines IL-1ss, IL-6 and TNF- alpha levels, when using Tris-HCl (p&lt;0.05).	pbs	79-82	interleukin 1 beta	Homo sapiens	127-131
25810567-5	2015	In addition, increased expression of IL-1beta and TNF-alpha could be blocked by treatment with TAK-242, a blocker of TLR4 signaling, and also by MyD88 inhibitory peptide (MIP).	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	95-102	interleukin 1 beta	Homo sapiens	37-45
26113783-4	2015	In our study, we first found that, after CAS, the serum IL-1beta, IL-6, TGF-beta, and MMP-9 levels were significantly increased, but only MMP-9 level was elevated no less than 3 months.	cas	41-44	interleukin 1 beta	Homo sapiens	56-64
26633920-9	2015	Interestingly, anti-LCSFA IgG neutralized PA-induced IL-1beta secretion by dendritic cells.	Protactinium	42-44	interleukin 1 beta	Homo sapiens	53-61
25676618-9	2015	Replenishing intracellular ascorbate, which is crucial in preventing HIF pathway activation, modified Co-induced HIF target gene expression and the inflammatory response, by decreasing interleukin-1 beta (IL-1beta) mRNA and protein expression.	Ascorbic Acid	27-36	interleukin 1 beta	Homo sapiens	185-203
25676618-9	2015	Replenishing intracellular ascorbate, which is crucial in preventing HIF pathway activation, modified Co-induced HIF target gene expression and the inflammatory response, by decreasing interleukin-1 beta (IL-1beta) mRNA and protein expression.	Ascorbic Acid	27-36	interleukin 1 beta	Homo sapiens	205-213
25312962-0	2015	Hydrogen sulphide decreases IL-1beta-induced activation of fibroblast-like synoviocytes from patients with osteoarthritis.	Hydrogen Sulfide	0-17	interleukin 1 beta	Homo sapiens	28-36
25312962-6	2015	NaHS treatment reduced both spontaneous and IL-1beta-induced secretion of IL-6, IL-8 and RANTES in different experimental settings.	sodium bisulfide	0-4	interleukin 1 beta	Homo sapiens	44-52
25312962-9	2015	NaHS treatment partially reduced IL-1beta-induced activation of several MAPK whereas it increased phosphorylation of pro-survival factor Akt1/2.	sodium bisulfide	0-4	interleukin 1 beta	Homo sapiens	33-41
25312962-10	2015	When cultured in spherical micromasses, FLS intentionally established a synovial lining layer-like structure; stimulation with IL-1beta altered the architecture of micromasses leading to hyperplasia of the lining layer which was completely inhibited by concomitant exposure to NaHS.	sodium bisulfide	277-281	interleukin 1 beta	Homo sapiens	127-135
25312962-11	2015	These data suggest that H2 S partially antagonizes IL-1beta stimulation via selective manipulation of the MAPkinase and the PI3K/Akt pathways which may encourage development of novel drugs for treatment of OA.	Hydrogen Sulfide	24-28	interleukin 1 beta	Homo sapiens	51-59
25124896-7	2015	Moreover, Bz-ATP significantly abrogated the inhibitory effects of levobupivacaine, as concentrations of IL-1beta, tumor necrosis factor alpha, IL-6, and macrophage inflammatory protein 2 of the LPS + Levo + Bz-ATP group were significantly higher than those of the LPS + Levo group (all P &lt; 0.05).	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	10-16	interleukin 1 beta	Homo sapiens	105-113
26284424-7	2015	Glu 64 of human IL-1beta is a pivotal epitope residue explaining the exquisite species specificity of canakinumab.	Glutamic Acid	0-3	interleukin 1 beta	Homo sapiens	16-24
26284424-8	2015	We identified marmoset as the only non-human primate species that carries Glu 64 in its IL-1beta and demonstrates full cross-reactivity of canakinumab, thereby enabling toxicological studies in this species.	Glutamic Acid	74-77	interleukin 1 beta	Homo sapiens	88-96
25428391-6	2015	In the present study, we found that silica particle was able to induce the secretion of interleukin-1beta from a Xuan Wei lung cancer cell line, XWLC-05.	Silicon Dioxide	36-42	interleukin 1 beta	Homo sapiens	88-105
25428391-8	2015	Interestingly, the interleukin 1 receptor antagonist and interleukin-1beta antibody can reduce silica particle-induced downregulation of mir-101.	Silicon Dioxide	95-101	interleukin 1 beta	Homo sapiens	57-74
25428391-8	2015	Interestingly, the interleukin 1 receptor antagonist and interleukin-1beta antibody can reduce silica particle-induced downregulation of mir-101.	mir-101	137-144	interleukin 1 beta	Homo sapiens	57-74
25428391-15	2015	Interleukin-1beta subsequently induces the downregulation of mir-101, which may result in the upregulated level of EZH2, and occurrence of lung cancer.	mir-101	61-68	interleukin 1 beta	Homo sapiens	0-17
26696754-5	2015	In addition, IL-1beta-induced cell migration in hypoxia was not affected when HIF-1alpha was inhibited by either siRNA or Topotecan, well known for its inhibitory effect on HIF-1alpha.	Topotecan	122-131	interleukin 1 beta	Homo sapiens	13-21
25446010-7	2015	BRE inhibited TNF-alpha/IL-1beta-induced NFkappaB p65 nuclear translocation, PGE2 production, up-regulation of COX-2, ICAM-1 and VCAM-1 gene and protein expression and leukocyte binding in HEMEC but not in HIMEC.	Dinoprostone	77-81	interleukin 1 beta	Homo sapiens	24-32
25234193-0	2015	Piperine inhibits IL-1beta-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells.	piperine	0-8	interleukin 1 beta	Homo sapiens	18-26
25234193-5	2015	Our results showed that piperine inhibited interleukin-1beta (IL-1beta)-induced IL-6 expression in a dose-dependent manner.	piperine	24-32	interleukin 1 beta	Homo sapiens	43-60
25234193-5	2015	Our results showed that piperine inhibited interleukin-1beta (IL-1beta)-induced IL-6 expression in a dose-dependent manner.	piperine	24-32	interleukin 1 beta	Homo sapiens	62-70
25234193-9	2015	Piperine inhibited IL-1beta-induced p38 MAPK and STAT3 activation and, in turn, blocked the IL-1beta-induced IL-6 expression.	piperine	0-8	interleukin 1 beta	Homo sapiens	19-27
25234193-9	2015	Piperine inhibited IL-1beta-induced p38 MAPK and STAT3 activation and, in turn, blocked the IL-1beta-induced IL-6 expression.	piperine	0-8	interleukin 1 beta	Homo sapiens	92-100
25234193-10	2015	Furthermore, gastric cancer cells pretreated with IL-1beta showed markedly enhanced invasiveness, which was partially abrogated by treatment with IL-6 siRNA, piperine, and inhibitors of p38 MAPK and STAT3.	piperine	158-166	interleukin 1 beta	Homo sapiens	50-58
25496183-2	2015	Bioassay guided fractionation of methanol extract based on inhibitory potential towards proinflammatory mediators (TNF-alpha, IL-1beta and nitric oxide (NO)) led to the identification of stigmasterol (1), lupeol (2), oleanolic acid (3), carissone (4) and scopoletin (5) as potential anti-inflammatory agents.	Stigmasterol	187-199	interleukin 1 beta	Homo sapiens	126-134
25764208-4	2015	Here, we describe the generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig) of the IgG1/k subtype that specifically and potently neutralizes IL-1alpha and IL-1beta.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	57-60	interleukin 1 beta	Homo sapiens	192-200
25764208-6	2015	ABT-981 specifically binds to IL-1alpha and IL-1beta, and is physically capable of binding 2 human IL-1alpha and 2 human IL-1beta molecules simultaneously.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	interleukin 1 beta	Homo sapiens	44-52
25764208-6	2015	ABT-981 specifically binds to IL-1alpha and IL-1beta, and is physically capable of binding 2 human IL-1alpha and 2 human IL-1beta molecules simultaneously.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	0-3	interleukin 1 beta	Homo sapiens	121-129
26710531-14	2015	CONCLUSION: Interrelationship of clinical-immunological effect of adamantilbromphenylamine has been revealed; intensity of production of IL 1beta may be considered as a criterion of prognosis of efficiency of treatment with adamantilbromphenylamine in patients with non-psychotic mental disorders.	adamantilbromphenylamine	66-90	interleukin 1 beta	Homo sapiens	137-145
25631505-0	2015	The effect of sodium hyaluronate treating knee osteoarthritis on synovial fluid interleukin -1beta and clinical treatment mechanism.	Hyaluronic Acid	14-32	interleukin 1 beta	Homo sapiens	80-98
25631505-1	2015	In order to explore the influence of sodium hyaluronate on knee osteoarthritis (KOA) patients synovial fluid interleukin -1beta (IL-1beta) and analyze its clinical mechanism, this study analyzed 40 cases of KOA patients in our hospital"s orthopaedic department, randomly divided them into two groups: Sodium hyaluronate group (group A) and normal saline group (group B), each consists 20 patients.	Hyaluronic Acid	37-55	interleukin 1 beta	Homo sapiens	109-127
25631505-1	2015	In order to explore the influence of sodium hyaluronate on knee osteoarthritis (KOA) patients synovial fluid interleukin -1beta (IL-1beta) and analyze its clinical mechanism, this study analyzed 40 cases of KOA patients in our hospital"s orthopaedic department, randomly divided them into two groups: Sodium hyaluronate group (group A) and normal saline group (group B), each consists 20 patients.	Hyaluronic Acid	37-55	interleukin 1 beta	Homo sapiens	129-137
25631505-5	2015	We can conclude that (1) IL-1beta content of knee joint synovial fluid in KOA patients before treatment was significantly higher than healthy people; (2) IL-1beta content of group A knee joint synovial fluid after treatment was significantly reduced than before treatment, there was no significant difference for group BIL-1beta content before and after treatment; (3) there was no significant difference between group A knee joint synovial fluid IL-1beta content after treatment and healthy people.	bil-1beta	319-328	interleukin 1 beta	Homo sapiens	154-162
25631505-5	2015	We can conclude that (1) IL-1beta content of knee joint synovial fluid in KOA patients before treatment was significantly higher than healthy people; (2) IL-1beta content of group A knee joint synovial fluid after treatment was significantly reduced than before treatment, there was no significant difference for group BIL-1beta content before and after treatment; (3) there was no significant difference between group A knee joint synovial fluid IL-1beta content after treatment and healthy people.	bil-1beta	319-328	interleukin 1 beta	Homo sapiens	154-162
25631505-6	2015	Thus it can be proved that content of IL-1beta in knee joint synovial fluid KOA patients is higher than healthy people; sodium hyaluronate can reduce the content of IL-1beta in synovial joints and can be effective in the treatment of knee osteoarthritis.	Hyaluronic Acid	120-138	interleukin 1 beta	Homo sapiens	38-46
25631505-6	2015	Thus it can be proved that content of IL-1beta in knee joint synovial fluid KOA patients is higher than healthy people; sodium hyaluronate can reduce the content of IL-1beta in synovial joints and can be effective in the treatment of knee osteoarthritis.	Hyaluronic Acid	120-138	interleukin 1 beta	Homo sapiens	165-173
25560300-7	2015	BDNF Val66Met interacted with both IL-1beta rs13032029 (Val/Met+ TT, PPerm = 0.029), and IL-6 rs2069837 (Val/Val+ AA, PPerm = 0.021) in Europeans, in addition to IL-1beta rs16944 (Val/Val+ GA, PPerm = 0.006) in African Americans.	Valine	5-8	interleukin 1 beta	Homo sapiens	35-43
25560300-7	2015	BDNF Val66Met interacted with both IL-1beta rs13032029 (Val/Met+ TT, PPerm = 0.029), and IL-6 rs2069837 (Val/Val+ AA, PPerm = 0.021) in Europeans, in addition to IL-1beta rs16944 (Val/Val+ GA, PPerm = 0.006) in African Americans.	Valine	5-8	interleukin 1 beta	Homo sapiens	162-170
25560300-7	2015	BDNF Val66Met interacted with both IL-1beta rs13032029 (Val/Met+ TT, PPerm = 0.029), and IL-6 rs2069837 (Val/Val+ AA, PPerm = 0.021) in Europeans, in addition to IL-1beta rs16944 (Val/Val+ GA, PPerm = 0.006) in African Americans.	Valine	56-59	interleukin 1 beta	Homo sapiens	35-43
25531650-9	2014	Treatment with MTX + OLM (5 mg/kg) resulted in a reduction of mucosal inflammatory infiltration, ulcerations, vasodilatation and haemorrhagic areas (p&lt;0.05) as well as reduced concentrations of MPO (p&lt;0.001) and the pro-inflammatory cytokines IL-1beta (p&lt;0.001) and TNF-a (p&lt;0.01), and increase anti-inflammatory cytocine IL-10 (p&lt;0.05).	olmesartan	21-24	interleukin 1 beta	Homo sapiens	249-257
26401715-0	2015	IL-1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients.	Glucose	73-80	interleukin 1 beta	Homo sapiens	0-5
26401715-0	2015	IL-1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients.	Metformin	100-109	interleukin 1 beta	Homo sapiens	0-5
26401715-7	2015	CONCLUSION: IL1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms may contribute to metformin"s glucose-lowing efficacy in overweight or obese Chinese T2DM patients.	Metformin	91-100	interleukin 1 beta	Homo sapiens	12-16
26401715-7	2015	CONCLUSION: IL1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms may contribute to metformin"s glucose-lowing efficacy in overweight or obese Chinese T2DM patients.	Glucose	103-110	interleukin 1 beta	Homo sapiens	12-16
25331710-7	2014	A significant negative correlation was also observed between 25-hydroxyvitamin D concentration and circulating concentrations of IL-1beta (r -0.323; P&lt;= 0.001) as well as IL-6 (r -0.154; P&lt;= 0.04), but not between 25-hydroxyvitamin D and TNF-alpha and IFN-gamma concentrations.	25-hydroxyvitamin D	61-80	interleukin 1 beta	Homo sapiens	129-137
25331710-8	2014	Furthermore, a significant difference in IL-1beta (P&lt;= 0.007) and IL-6 (P&lt;= 0.02) concentrations was observed in patients with severe 25-hydroxyvitamin D deficiency compared with patients with 25-hydroxyvitamin D concentration &gt;= 25 nmol/l, and this difference was remarkable for TNF-alpha.	25-hydroxyvitamin D	140-159	interleukin 1 beta	Homo sapiens	41-49
25531650-0	2014	Olmesartan decreased levels of IL-1beta and TNF-alpha, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model.	olmesartan	0-10	interleukin 1 beta	Homo sapiens	31-39
25531650-9	2014	Treatment with MTX + OLM (5 mg/kg) resulted in a reduction of mucosal inflammatory infiltration, ulcerations, vasodilatation and haemorrhagic areas (p&lt;0.05) as well as reduced concentrations of MPO (p&lt;0.001) and the pro-inflammatory cytokines IL-1beta (p&lt;0.001) and TNF-a (p&lt;0.01), and increase anti-inflammatory cytocine IL-10 (p&lt;0.05).	Methotrexate	15-18	interleukin 1 beta	Homo sapiens	249-257
26710531-14	2015	CONCLUSION: Interrelationship of clinical-immunological effect of adamantilbromphenylamine has been revealed; intensity of production of IL 1beta may be considered as a criterion of prognosis of efficiency of treatment with adamantilbromphenylamine in patients with non-psychotic mental disorders.	adamantilbromphenylamine	224-248	interleukin 1 beta	Homo sapiens	137-145
25445040-3	2014	Specific inhibitors of growth-related signal transducers, such as AG1478, LY294002, PD98059, and rapamycin, completely abolished IL-1beta-stimulated hepatocyte DNA synthesis and proliferation.	RTKI cpd	66-72	interleukin 1 beta	Homo sapiens	129-137
25445040-3	2014	Specific inhibitors of growth-related signal transducers, such as AG1478, LY294002, PD98059, and rapamycin, completely abolished IL-1beta-stimulated hepatocyte DNA synthesis and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	interleukin 1 beta	Homo sapiens	129-137
25446924-5	2014	Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1beta expression.	epigallocatechin gallate	24-28	interleukin 1 beta	Homo sapiens	157-165
25446924-5	2014	Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1beta expression.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	157-165
25445040-3	2014	Specific inhibitors of growth-related signal transducers, such as AG1478, LY294002, PD98059, and rapamycin, completely abolished IL-1beta-stimulated hepatocyte DNA synthesis and proliferation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	84-91	interleukin 1 beta	Homo sapiens	129-137
25446924-5	2014	Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1beta expression.	Luteolin	11-19	interleukin 1 beta	Homo sapiens	157-165
25445040-3	2014	Specific inhibitors of growth-related signal transducers, such as AG1478, LY294002, PD98059, and rapamycin, completely abolished IL-1beta-stimulated hepatocyte DNA synthesis and proliferation.	Sirolimus	97-106	interleukin 1 beta	Homo sapiens	129-137
25501336-0	2014	Pheophytin a inhibits inflammation via suppression of LPS-induced nitric oxide synthase-2, prostaglandin E2, and interleukin-1beta of macrophages.	pheophytin a	0-12	interleukin 1 beta	Homo sapiens	113-130
25495224-3	2014	RESULTS: The effect of IL-1beta, but not of TNF-alpha, on glutamate-mediated excitatory postsynaptic currents was blocked by pifithrin-alpha (PFT), inhibitor of p53.	Glutamic Acid	58-67	interleukin 1 beta	Homo sapiens	23-31
25495224-3	2014	RESULTS: The effect of IL-1beta, but not of TNF-alpha, on glutamate-mediated excitatory postsynaptic currents was blocked by pifithrin-alpha (PFT), inhibitor of p53.	pifithrin	125-140	interleukin 1 beta	Homo sapiens	23-31
25385822-3	2014	In this study, we investigated the effect of CHQ on human monocyte-derived Langerhans-like cells (MoLC) and dendritic cells (MoDC) in response to IL-1beta.	Chloroquine	45-48	interleukin 1 beta	Homo sapiens	146-154
25514563-10	2014	The release of platelet inflammatory mediators (IL-1beta, TGF-beta1, CCL5 and thromboxane B2) induced by ADP was inhibited by Eruca sativa Mill.	Adenosine Diphosphate	105-108	interleukin 1 beta	Homo sapiens	48-56
25501336-4	2014	We found that pre-treatment with pheophytin a suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-1beta in RAW 264.7 macrophages.	pheophytin a	33-45	interleukin 1 beta	Homo sapiens	138-155
25486008-4	2014	METHODS AND RESULTS: IFNT dose-dependently inhibited IL-1beta secretion induced by nano-silica, a well-known activators of NLRP3 inflammasomes, in human macrophages primed with lipopolysaccharide (LPS, TLR4 agonist) and Pam3CSK4 (TLR1/2 agonist).	Silicon Dioxide	88-94	interleukin 1 beta	Homo sapiens	53-61
25465897-5	2014	Finally, p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 and stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) inhibitor SP600125 were used to pick out the pathway that mediated the IL-1beta-modulated PGs synthesis and gene expression of UGDH, Sp1, Sp3 and c-Krox.	Phosphatidylglycerols	232-235	interleukin 1 beta	Homo sapiens	213-221
25474105-8	2014	Ramipril reduces mRNA expression of multiple pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, TNF -alpha, Interferon-[Formula: see text], and MCP-1, as well as aortic wall IL-8 and MCP-1 (P = 0.017 and 0.008, respectively) protein content.	Ramipril	0-8	interleukin 1 beta	Homo sapiens	80-88
25463072-7	2014	RESULTS: In separate SMC and monocyte cultures (monocultures) 25-hydroxycholesterol only poorly activated IL-1, IL-6 and MCP-1 production, whereas LPS stimulated much higher cytokine levels than unstimulated cultures.	25-hydroxycholesterol	62-83	interleukin 1 beta	Homo sapiens	106-110
24013646-7	2014	Tofacitinib suppressed tumour necrosis factor, interleukin (IL)-6 and IL-1beta production without affecting transforming growth factor (TGF)-beta and IL-10 production.	tofacitinib	0-11	interleukin 1 beta	Homo sapiens	70-78
25150534-4	2014	RESULTS: High concentrations of glucose increased the production of pro-inflammatory cytokines interleukin-1 beta (IL-1beta), tumour necrosis factor alpha (TNF-alpha), Interleukin-6 (IL-6) at both mRNA and protein levels, and receptor activator of NF-kB ligand (RANKL) at mRNA levels in hPDL cells.	Glucose	32-39	interleukin 1 beta	Homo sapiens	95-113
25150534-4	2014	RESULTS: High concentrations of glucose increased the production of pro-inflammatory cytokines interleukin-1 beta (IL-1beta), tumour necrosis factor alpha (TNF-alpha), Interleukin-6 (IL-6) at both mRNA and protein levels, and receptor activator of NF-kB ligand (RANKL) at mRNA levels in hPDL cells.	Glucose	32-39	interleukin 1 beta	Homo sapiens	115-123
25268952-3	2014	Here, we report that inhibition of proteasomal degradation with MG-132 and autophagy with bafilomycin A1 resulted in the release of IL-1beta but not that of IL-18 in human ARPE-19 cells.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	64-70	interleukin 1 beta	Homo sapiens	132-140
25268952-3	2014	Here, we report that inhibition of proteasomal degradation with MG-132 and autophagy with bafilomycin A1 resulted in the release of IL-1beta but not that of IL-18 in human ARPE-19 cells.	bafilomycin	90-101	interleukin 1 beta	Homo sapiens	132-140
25268952-6	2014	Along with IL-1beta, exposure to MG-132 and bafilomycin A1 resulted in the secretion of IL-8.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	33-39	interleukin 1 beta	Homo sapiens	11-19
25463072-9	2014	Blocking experiments with IL-1-receptor antagonist showed that IL-1 decisively contributed to the 25-hydroxycholesterol-induced synergistic IL-6 and MCP-1 production.	Hydroxycholesterols	101-119	interleukin 1 beta	Homo sapiens	26-30
25435722-0	2014	Assessment of interleukin 1beta serum level in different responder groups and stages of chronic myeloid leukemia patients on imatinb mesylate therapy.	imatinb mesylate	125-141	interleukin 1 beta	Homo sapiens	14-31
25447760-3	2014	150 kGy gamma-irradiated genistein did not exert cytotoxicity in macrophages, and inhibited inducible nitric oxide synthase-mediated nitric oxide production and pro-inflammatory cytokines level, such as tumor necrosis factor-alpha, interleukin-6 and interleukin-1beta, in lipopolysaccharide (LPS)-induced macrophages.	Genistein	25-34	interleukin 1 beta	Homo sapiens	250-267
25315747-6	2014	Human platelets responded to poly I:C by increasing [Ca(2+)]i, the percentages of cells expressing TLR4 and CD62P, and by releasing CXCL4 and IL-1beta in comparison to unstimulated platelets.	Poly I-C	29-37	interleukin 1 beta	Homo sapiens	142-150
25281528-6	2014	Moreover, the silencing of the Nlrp3 gene or the use of the caspase-1 inhibitor Z-VAD-fmk significantly attenuated the albumin-induced increase in IL-1beta and IL-18 expression in HK2 cells.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	80-89	interleukin 1 beta	Homo sapiens	147-155
25445147-5	2014	Importantly, we provided evidence to suggest that macrophage cell membrane binding to immobilized crystals was sufficient to induce IL-1beta release, and this activation of the NLRP3 inflammasome was inhibited by blocking potassium efflux.	Potassium	222-231	interleukin 1 beta	Homo sapiens	132-140
25229165-4	2014	In placental samples (N=70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1beta (p=0.03).	Arsenic	53-60	interleukin 1 beta	Homo sapiens	126-133
25447842-0	2014	Possible implications of Ni(II) on oral IL-1beta-induced inflammatory processes.	Nickel(2+)	25-31	interleukin 1 beta	Homo sapiens	40-48
25447842-15	2014	SIGNIFICANCE: Our in vitro study implicated that Ni(II) has various modifying effects on IL-1beta-induced inflammatory processes depending on the concentration.	Nickel(2+)	49-55	interleukin 1 beta	Homo sapiens	89-97
25229885-0	2014	Complement C5a potentiates uric acid crystal-induced IL-1beta production.	Uric Acid	27-36	interleukin 1 beta	Homo sapiens	53-61
25229885-2	2014	The pathogenesis of gout was identified as uric acid crystal deposition in the joints that activates inflammasome, leading to IL-1beta release.	Uric Acid	43-52	interleukin 1 beta	Homo sapiens	126-134
25229885-7	2014	Our results provide insight into the role of C5a as an endogenous priming signal that is required for the initiation of uric acid crystal-induced IL-1beta production.	Uric Acid	120-129	interleukin 1 beta	Homo sapiens	146-154
25236743-6	2014	Moreover, we observed that in a first phase, DNFB-induced ATF4 upregulates IL8 mRNA levels while blocking CD86, IL1B, IL12B, and CXL10 transcription.	Dinitrofluorobenzene	45-49	interleukin 1 beta	Homo sapiens	112-116
25435722-6	2014	This study designed to assess the behavior of IL-1beta through newly diagnosed patients, different responders groups (optimal, suboptimal and failure cytogenetic response) and advanced stages (acceleration and crisis groups) of CML Iraqi patients whom receiving Imatinib mesylate (tyrosine kinase inhibitor), trying to elucidate the role of immunity in pathophysiology of CML disease development and treatments.	Imatinib Mesylate	262-279	interleukin 1 beta	Homo sapiens	46-54
25435722-7	2014	In this study 96 Iraqi CML patients under imatinib mesylate treatment categorized by complete blood picture and fluorescent in situ hybridization analysis into different response groups and stages, then used an enzyme linked immunosorbent assay technique to assess serum level of IL-1beta in each response group and advance stage (acceleration and transformed) of CML patients, in comparison to level in 32 healthy control subjects and 32 newly diagnosed CML.	Imatinib Mesylate	42-59	interleukin 1 beta	Homo sapiens	280-288
25270538-0	2014	Effects of icariin on the regulation of the OPG-RANKL-RANK system are mediated through the MAPK pathways in IL-1beta-stimulated human SW1353 chondrosarcoma cells.	icariin	11-18	interleukin 1 beta	Homo sapiens	108-116
25270538-8	2014	The results from western blot analysis revealed that treatment with icariin decreased the levels of p-p38 and increased the levels of p-ERK1/2 in the IL-1beta-stimulated SW1353 cells.	icariin	68-75	interleukin 1 beta	Homo sapiens	150-158
25319133-0	2014	Prednisone inhibits the IL-1beta-induced expression of COX-2 in HEI-OC1 murine auditory cells through the inhibition of ERK-1/2, JNK-1 and AP-1 activity.	Prednisone	0-10	interleukin 1 beta	Homo sapiens	24-32
25319133-4	2014	The exposure of HEI-OC1 cells to IL-1beta increased COX-2 protein and mRNA expression, COX-2 promoter-driven luciferase activity and COX-2 enzymatic activity [as indicated by the increased production of prostaglandin E2 (PGE2), a major COX-2 metabolite].	Dinoprostone	203-219	interleukin 1 beta	Homo sapiens	33-41
25319133-4	2014	The exposure of HEI-OC1 cells to IL-1beta increased COX-2 protein and mRNA expression, COX-2 promoter-driven luciferase activity and COX-2 enzymatic activity [as indicated by the increased production of prostaglandin E2 (PGE2), a major COX-2 metabolite].	Dinoprostone	221-225	interleukin 1 beta	Homo sapiens	33-41
25319133-5	2014	However, PDN markedly inhibited the IL-1beta-induced COX-2 protein and mRNA expression, COX-2 promoter activity and PGE2 production in the HEI-OC1 cells without affecting COX-2 protein and mRNA stability.	Dinoprostone	116-120	interleukin 1 beta	Homo sapiens	36-44
25319133-8	2014	Of note, the inhibitory effects of PDN on the IL-1beta-induced expression of COX-2 and the activation of ERK-1/2 and JNK-1 in the HEI-OC1 cells were significantly diminished by RU486, a glucocorticoid receptor (GR) antagonist, suggesting that PDN exerts its inhibitory effects through GR.	Mifepristone	177-182	interleukin 1 beta	Homo sapiens	46-54
25319548-10	2014	Genistein significantly decreased IL-6 and IL-1beta mRNA levels, as well as IL-6 production in PMA/A23187-induced mast cells activation.	Genistein	0-9	interleukin 1 beta	Homo sapiens	43-51
25674248-0	2014	Chlorogenic acid suppresses interleukin-1beta-induced inflammatory mediators in human chondrocytes.	Chlorogenic Acid	0-16	interleukin 1 beta	Homo sapiens	28-45
25306296-9	2014	P2X7 receptor activation by UVB and LL-37 resulted in an increase in intracellular calcium concentrations, which enhances inflammasome activation and subsequent IL-1beta release.	Calcium	83-90	interleukin 1 beta	Homo sapiens	161-169
25465718-7	2014	Aaptamine also decreased proinflammatory cytokines such as cyclooxygenase-2, tumor necrosis factor-alpha, interleukin-1beta, and nuclear factor-kappa B subunits in UVB-irradiated human keratinocytes.	aaptamine	0-9	interleukin 1 beta	Homo sapiens	106-123
25674248-1	2014	We investigated the anti-inflammatory properties of chlorogenic acid (CGA) in interleukin-1beta-induced chondrocytes.	Chlorogenic Acid	52-68	interleukin 1 beta	Homo sapiens	78-95
25674248-1	2014	We investigated the anti-inflammatory properties of chlorogenic acid (CGA) in interleukin-1beta-induced chondrocytes.	Chlorogenic Acid	70-73	interleukin 1 beta	Homo sapiens	78-95
25545915-5	2014	The antagonistic effects of bornyl acetate on IL-1beta induced targets MMP-1 and MMP-13 were diminished by IL-11 knockdown.	bornyl acetate	28-42	interleukin 1 beta	Homo sapiens	46-54
25745771-0	2014	Influence of inositol hexaphosphate on the expression of selected proliferation markers in IL-1beta-stimulated intestinal epithelial cells.	Phytic Acid	13-35	interleukin 1 beta	Homo sapiens	91-99
25443723-0	2014	Concentration of Il-1beta, Il-2, Il-6, TNFalpha in the blood serum in children with generalized epilepsy treated by valproate.	Valproic Acid	116-125	interleukin 1 beta	Homo sapiens	17-25
25394199-8	2014	Treatment with 1 inhibited carrageenan-induced production of TNF-alpha, IL-1beta, IL-33, and IL-10 and nuclear factor kappaB activation.	Carrageenan	27-38	interleukin 1 beta	Homo sapiens	72-80
25135357-2	2014	At molecular level, GSNO effects have been shown to modulate the activity of a series of transcription factors (notably NF-kappaB, AP-1, CREB and others) as well as other components of signal transduction chains (e.g. IKK-beta, caspase 1, calpain and others), resulting in the modulation of several cytokines and chemokines expression (TNFalpha, IL-1beta, IFN-gamma, IL-4, IL-8, RANTES, MCP-1 and others).	S-Nitrosoglutathione	20-24	interleukin 1 beta	Homo sapiens	346-354
25448682-9	2014	The results from in vitro assays showed that fraxinellone significantly reduced lipopolysaccharide (LPS)-induced production of nitric oxide (NO), IL-1beta and IL-18 as well as the activity of iNOS in both THP-1 cells and mouse primary peritoneal macrophages.	fraxinellone	45-57	interleukin 1 beta	Homo sapiens	146-154
25389767-6	2014	The cleavage of caspase-1 was observed in 5-FU-treated cells, which was followed by an increased secretion of interleukin (IL)-1beta.	Fluorouracil	42-46	interleukin 1 beta	Homo sapiens	110-132
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	25-33
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	74-82
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	181-188
25146005-7	2014	We further demonstrated that CSFV viroporin p7 protein induced IL-1beta secretion which could be inhibited by the ion channel blocker amantadine and also discovered that p7 protein was a short-lived protein degraded by the proteasome.	Amantadine	134-144	interleukin 1 beta	Homo sapiens	63-71
25245200-7	2014	Pam3-Cys-SK4-stimulated secretion of interleukin-1beta (-35%, P = .005), interleukin-6 (-32%, P = .01), and tumor necrosis factor-alpha (-33%, P = .06) was reduced following the HFD.	pam3-cys-sk4	0-12	interleukin 1 beta	Homo sapiens	37-54
25240206-8	2014	We further explored vitamin D"s association with plasma IL-1beta, IL-6 and TNF-alpha.	Vitamin D	20-29	interleukin 1 beta	Homo sapiens	56-64
25240206-12	2014	Low vitamin D levels were associated with higher levels of the inflammatory cytokines IL-6 and IL-1beta in the blood.	Vitamin D	4-13	interleukin 1 beta	Homo sapiens	95-103
25396430-5	2014	This trend was also observed with each step of the signaling mechanism for IL-1beta production, which is a single pathway affiliated with ROS generation or lysosomal rupture or both, cathepsin B, caspase-1 (NALP3 inflammasome), and finally IL-1beta production in THP-1 cells.	ros	138-141	interleukin 1 beta	Homo sapiens	75-83
25091291-5	2014	When challenged with a well-characterized biopolymer, poly(lactic-co-glycolic acid), the co-cultured human cells secreted elevated levels of IL-1beta, IL-6, GM-CSF and TNF-alpha.	Polylactic Acid-Polyglycolic Acid Copolymer	54-82	interleukin 1 beta	Homo sapiens	141-149
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	74-82
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	329-336
25745771-1	2014	The aim of the present study was to examine the influence of IP6, a naturally occurring phytochem- ical, on the expression of genes coding for proliferation markers, i.e., cyclin D1 (CCND1) and histone H3 in IL-1beta-stimulated intestinal cancer cell line Caco-2.	Phytic Acid	61-64	interleukin 1 beta	Homo sapiens	208-216
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	25-33
25745771-2	2014	Quantification of genes expression was carried out using real time RT-QPCR technique in Caco-2 cells after treatment with IL-1beta, 1 and 2.5 mM of IP6 for 3, 6 and 12 h. In separate cultures, cells were incubated with IL-1beta for the indicated times.	Phytic Acid	148-151	interleukin 1 beta	Homo sapiens	122-139
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	74-82
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	181-188
24974860-0	2014	IL-1beta increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells.	Tryptophan	33-43	interleukin 1 beta	Homo sapiens	0-8
25745771-5	2014	IP6 had no influence on IL-1beta-stimulated CCND1 expression for 3 and 6 h. After 12 h, statistically significant decrease in CCND1 mRNA was observed in cells exposed to IL-1beta and IP6 (1 and 2.5 mM) in relation to cells treated with IL-1beta only.	Phytic Acid	0-3	interleukin 1 beta	Homo sapiens	170-178
24974860-3	2014	We studied whether interleukin-1beta (IL-1beta), a typical endometriosis-associated cytokine, affects the expression of TDO and the catabolism of tryptophan in endometrioma stromal cells (ESCs).	Tryptophan	146-156	interleukin 1 beta	Homo sapiens	19-36
24974860-3	2014	We studied whether interleukin-1beta (IL-1beta), a typical endometriosis-associated cytokine, affects the expression of TDO and the catabolism of tryptophan in endometrioma stromal cells (ESCs).	Tryptophan	146-156	interleukin 1 beta	Homo sapiens	38-46
24974860-13	2014	IL-1beta-treated ESCs increased the production of kynurenine and the effect was inhibited by TDO siRNA.	Kynurenine	50-60	interleukin 1 beta	Homo sapiens	0-8
24974860-15	2014	CONCLUSION: IL-1beta is suggested to stimulate tryptophan catabolism and production of IL-6 and IL-8 by increasing TDO expression in endometriosis.	Tryptophan	47-57	interleukin 1 beta	Homo sapiens	12-20
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	74-82
25745771-6	2014	The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells.	Phytic Acid	152-155	interleukin 1 beta	Homo sapiens	329-336
25745771-5	2014	IP6 had no influence on IL-1beta-stimulated CCND1 expression for 3 and 6 h. After 12 h, statistically significant decrease in CCND1 mRNA was observed in cells exposed to IL-1beta and IP6 (1 and 2.5 mM) in relation to cells treated with IL-1beta only.	Phytic Acid	0-3	interleukin 1 beta	Homo sapiens	170-178
24890258-5	2014	Here, we investigated the effect of zerumbone (ZER) on IL-1beta-induced cell migration and invasion in breast cancer cells.	zerumbone	36-45	interleukin 1 beta	Homo sapiens	55-63
24629538-12	2014	Activated proinflammatory pathways, in particular, IL-8 and IL-1beta, were positively correlated with alcohol consumption and alcohol-craving scores.	Alcohols	102-109	interleukin 1 beta	Homo sapiens	60-68
24629538-12	2014	Activated proinflammatory pathways, in particular, IL-8 and IL-1beta, were positively correlated with alcohol consumption and alcohol-craving scores.	Alcohols	126-133	interleukin 1 beta	Homo sapiens	60-68
25175736-5	2014	SFAs (saturated fatty acids), unlike UFAs (unsaturated fatty acids), have recently been proposed as triggers of the NLRP3 inflammasome, a molecular platform mediating the processing of IL-1beta in response to infection and stress conditions.	Fatty Acids	6-27	interleukin 1 beta	Homo sapiens	185-193
25436985-12	2014	IL-1beta levels were correlated with expression of CRP, ROS, and PWV.	Reactive Oxygen Species	56-59	interleukin 1 beta	Homo sapiens	0-8
25091898-6	2014	In addition, we critically evaluate controversial evidence suggesting a specific role for mitochondrial reactive oxygen species in the activation of the NLRP3 inflammasome, a multiprotein complex that mediates the production of IL-1beta and IL-18.	Reactive Oxygen Species	104-127	interleukin 1 beta	Homo sapiens	228-236
24217221-5	2014	We found that several ER stress-inducing chemicals and the free fatty acid palmitate can trigger IL-1beta secretion in various cell types, including monocytic leukemia cells, primary macrophages and differentiated adipocytes.	free fatty acid palmitate	59-84	interleukin 1 beta	Homo sapiens	97-105
24217221-7	2014	Enhanced IL-1beta secretion depended on the activation of the NLRP3 inflammasome through a mechanism involving reactive oxygen species formation and activation of thioredoxin-interacting protein.	Reactive Oxygen Species	111-134	interleukin 1 beta	Homo sapiens	9-17
24217221-8	2014	Chemical chaperone treatment and the pharmacological application of carbon monoxide inhibited IL-1beta secretion in response to ER stress.	Carbon Monoxide	68-83	interleukin 1 beta	Homo sapiens	94-102
24323452-6	2014	Cathepsin B is required for PSK-induced inflammasome activation as CA-074-Me, a cathepsin B inhibitor, significantly decreased PSK-induced IL-1beta.	CA 074 methyl ester	67-76	interleukin 1 beta	Homo sapiens	139-147
25116441-7	2014	Mechanistically, [Ru(HEDTA)NO] inhibited carrageenin-induced production of the hyperalgesic cytokines tumor necrosis factor-alpha and interleukin-1beta, and decrease of reduced glutathione levels.	ru(hedta)	18-27	interleukin 1 beta	Homo sapiens	134-151
25116441-7	2014	Mechanistically, [Ru(HEDTA)NO] inhibited carrageenin-induced production of the hyperalgesic cytokines tumor necrosis factor-alpha and interleukin-1beta, and decrease of reduced glutathione levels.	Carrageenan	41-52	interleukin 1 beta	Homo sapiens	134-151
24890258-0	2014	Zerumbone suppresses IL-1beta-induced cell migration and invasion by inhibiting IL-8 and MMP-3 expression in human triple-negative breast cancer cells.	zerumbone	0-9	interleukin 1 beta	Homo sapiens	21-29
25194676-4	2014	1,25(OH)2D3 significantly suppressed all the CFA induced pro-inflammatory cytokines (p&lt;0.05) studied except IL-1beta in both HCs and PTB patients.	Calcitriol	0-11	interleukin 1 beta	Homo sapiens	111-119
24737200-7	2014	Serum enhanced silica-induced interleukin (IL)-6, IL-10, IL-1beta and MCP-1 release, whereas albumin partially inhibited MCP-1 release.	Silicon Dioxide	15-21	interleukin 1 beta	Homo sapiens	57-65
25078146-12	2014	In response to glucose ingestion, MNC-derived TNFalpha, IL-6, and IL-1beta release decreased in both normal-weight control groups but failed to suppress in either normal-weight PCOS group and in obese women regardless of PCOS status.	Glucose	15-22	interleukin 1 beta	Homo sapiens	66-74
24952412-6	2014	RESULTS: Lidocaine (&gt;=2 mug/mL) significantly inhibited the release and expression of nitric oxide, monocyte chemotactic protein 1, prostaglandin E2, interleukin 1beta, and tumor necrosis factor alpha in LPS-activated microglia.	Lidocaine	9-18	interleukin 1 beta	Homo sapiens	153-170
25185259-8	2014	Consequently, hypoxic human macrophages secreted higher amounts of mature IL-1beta than did normoxic macrophages after treatment with crystalline cholesterol, an endogenous danger signal that contributes to atherogenesis.	Cholesterol	146-157	interleukin 1 beta	Homo sapiens	74-82
25356049-8	2014	ELISA analysis revealed that oridonin down-regulated the inflammatory factors IL-1beta, IL-6, and IL-33 in a dose-dependent manner.	oridonin	29-37	interleukin 1 beta	Homo sapiens	78-86
29123689-1	2015	Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2).	Prostaglandins	172-185	interleukin 1 beta	Homo sapiens	70-92
29123689-1	2015	Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2).	Oxygen	272-278	interleukin 1 beta	Homo sapiens	70-92
29123689-1	2015	Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2).	Oxygen	217-223	interleukin 1 beta	Homo sapiens	70-92
29123689-1	2015	Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2).	vo2	292-295	interleukin 1 beta	Homo sapiens	70-92
25164813-5	2014	Biochemical analyses showed that poly(dA-dT)-activated AIM2 inflammasomes induce autophagy and IL-1beta secretion in an LC3-dependent fashion.	Poly dA-dT	33-44	interleukin 1 beta	Homo sapiens	95-103
29123689-1	2015	Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2).	Oxygen	272-278	interleukin 1 beta	Homo sapiens	70-92
29123689-1	2015	Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2).	do2	317-320	interleukin 1 beta	Homo sapiens	70-92
25330300-12	2014	MTX at a concentration of 10 microM also increased inflammatory cytokines (IL-1beta, IL-6, TNFalpha and Iggamma) and decreased the level of IL-10 anti-inflammatory cytokine, independent of SOD2 genetic background.	Methotrexate	0-3	interleukin 1 beta	Homo sapiens	75-83
25323788-5	2014	The inflammatory-related cytokines interleukin (IL)-1beta, IL-6 and IL-8 were detected after pretreatment with the alpha1/beta2-AR blockers phentolamine/propranolol, both in vitro and in vivo.	Phentolamine	140-152	interleukin 1 beta	Homo sapiens	35-57
25323788-5	2014	The inflammatory-related cytokines interleukin (IL)-1beta, IL-6 and IL-8 were detected after pretreatment with the alpha1/beta2-AR blockers phentolamine/propranolol, both in vitro and in vivo.	Propranolol	153-164	interleukin 1 beta	Homo sapiens	35-57
25344730-10	2014	With zymosan, "flare" ASD-IS cells produced more IL-1beta than most control cells, despite spontaneous production of large amounts of IL-1ss.	Zymosan	5-12	interleukin 1 beta	Homo sapiens	49-57
25065288-0	2014	Suppression of the pro-inflammatory NLRP3/interleukin-1beta pathway in macrophages by the thioredoxin reductase inhibitor auranofin.	Auranofin	122-131	interleukin 1 beta	Homo sapiens	42-59
25344730-10	2014	With zymosan, "flare" ASD-IS cells produced more IL-1beta than most control cells, despite spontaneous production of large amounts of IL-1ss.	Zymosan	5-12	interleukin 1 beta	Homo sapiens	49-53
25107704-5	2014	Of interest, secretion of interleukin-1beta was increased by archazolid.	archazolid	61-71	interleukin 1 beta	Homo sapiens	26-43
25225670-1	2014	The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (Nlrp3) inflammasome plays an important role in inflammation by controlling the maturation and secretion of the cytokines IL-1beta and IL-18 in response to multiple stimuli including pore-forming toxins, particulate matter, and ATP.	Adenosine Triphosphate	314-317	interleukin 1 beta	Homo sapiens	208-216
25225670-3	2014	In this study, we found that cytosolic poly(I:C), but not total RNA from healthy macrophages, macrophages undergoing pyroptosis, or mitochondrial RNA, induces caspase-1 activation and IL-1beta release through the Nlrp3 inflammasome.	poly	39-43	interleukin 1 beta	Homo sapiens	184-192
25056289-6	2014	Furthermore, as little as 5 muM L-K6 significantly inhibited lipopolysaccharide (LPS)- and interleukin-1beta-induced productions of interleukin-8 and tumor necrosis factor-alpha from THP-1 monocytic cells.	l-k6	32-36	interleukin 1 beta	Homo sapiens	91-108
25218635-3	2014	Simplexin, a daphnane diterpene ester, was identified for the first time from this genus and caused an increase in the production of cytokines (IFNgamma, IL1beta, IL6, and IL13) by peripheral blood mononuclear cells.	simplexin	0-9	interleukin 1 beta	Homo sapiens	154-161
25333949-5	2014	Additionally, the complexes 1-5 significantly influence the secretion and expression of pro-inflammatory cytokines TNF-alpha and IL-1beta by a similar manner as a commercially used anti-arthritic drug Auranofin.	Auranofin	201-210	interleukin 1 beta	Homo sapiens	129-137
25065288-8	2014	In addition, qPCR and Western blot analyses showed that auranofin impaired TLR4-dependent induction of the inflammasome receptor NLRP3, which plays a critical role in IL-1beta processing.	Auranofin	56-65	interleukin 1 beta	Homo sapiens	167-175
25065288-9	2014	Consistent with these findings, inflammasome-dependent release of IL-1beta from stimulated macrophages was suppressed by auranofin as was inflammasome-mediated cell death.	Auranofin	121-130	interleukin 1 beta	Homo sapiens	66-74
25022544-7	2014	To determine the role of PKC activation in the effects of DPP-4 inhibitors, cells were treated with PMA- which blocked the effect of DPP-4 inhibitors on NLRP3 and IL-1beta as well as TLR4 and GLP-1R.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 beta	Homo sapiens	163-171
25046000-0	2014	Production of IL-1beta by bone marrow-derived macrophages in response to chemotherapeutic drugs: synergistic effects of doxorubicin and vincristine.	Doxorubicin	120-131	interleukin 1 beta	Homo sapiens	14-22
25046000-0	2014	Production of IL-1beta by bone marrow-derived macrophages in response to chemotherapeutic drugs: synergistic effects of doxorubicin and vincristine.	Vincristine	136-147	interleukin 1 beta	Homo sapiens	14-22
25046000-4	2014	Seven of them (melphalan, cisplatin, vincristine, etoposide, paclitaxel, methotrexate, and cytarabine) caused the production of IL-1beta in cells pretreated with lipopolysaccharide.	Melphalan	15-24	interleukin 1 beta	Homo sapiens	128-136
25046000-4	2014	Seven of them (melphalan, cisplatin, vincristine, etoposide, paclitaxel, methotrexate, and cytarabine) caused the production of IL-1beta in cells pretreated with lipopolysaccharide.	Cisplatin	26-35	interleukin 1 beta	Homo sapiens	128-136
25046000-4	2014	Seven of them (melphalan, cisplatin, vincristine, etoposide, paclitaxel, methotrexate, and cytarabine) caused the production of IL-1beta in cells pretreated with lipopolysaccharide.	Vincristine	37-48	interleukin 1 beta	Homo sapiens	128-136
25046000-4	2014	Seven of them (melphalan, cisplatin, vincristine, etoposide, paclitaxel, methotrexate, and cytarabine) caused the production of IL-1beta in cells pretreated with lipopolysaccharide.	Etoposide	50-59	interleukin 1 beta	Homo sapiens	128-136
25046000-4	2014	Seven of them (melphalan, cisplatin, vincristine, etoposide, paclitaxel, methotrexate, and cytarabine) caused the production of IL-1beta in cells pretreated with lipopolysaccharide.	Paclitaxel	61-71	interleukin 1 beta	Homo sapiens	128-136
25046000-4	2014	Seven of them (melphalan, cisplatin, vincristine, etoposide, paclitaxel, methotrexate, and cytarabine) caused the production of IL-1beta in cells pretreated with lipopolysaccharide.	Methotrexate	73-85	interleukin 1 beta	Homo sapiens	128-136
25046000-4	2014	Seven of them (melphalan, cisplatin, vincristine, etoposide, paclitaxel, methotrexate, and cytarabine) caused the production of IL-1beta in cells pretreated with lipopolysaccharide.	Cytarabine	91-101	interleukin 1 beta	Homo sapiens	128-136
25046000-5	2014	When delivered in combination with doxorubicin, one of the drugs, vincristine, was also capable of synergistically activating the NLRP3-dependent inflammasome and increasing expression of IL-1beta, IL-6, and CXCL1.	Doxorubicin	35-46	interleukin 1 beta	Homo sapiens	188-196
25046000-5	2014	When delivered in combination with doxorubicin, one of the drugs, vincristine, was also capable of synergistically activating the NLRP3-dependent inflammasome and increasing expression of IL-1beta, IL-6, and CXCL1.	Vincristine	66-77	interleukin 1 beta	Homo sapiens	188-196
25046000-7	2014	Three small-molecule inhibitors known to suppress activity of kinases situated upstream of mitogen-activated kinases (MAPKs) inhibited the expression of IL-1beta, IL-6, and CXCL1 when doxorubicin and vincristine were used singly or together, so specific kinase inhibitors may be useful in reducing inflammation in patients receiving chemotherapy.	Doxorubicin	184-195	interleukin 1 beta	Homo sapiens	153-161
25046000-7	2014	Three small-molecule inhibitors known to suppress activity of kinases situated upstream of mitogen-activated kinases (MAPKs) inhibited the expression of IL-1beta, IL-6, and CXCL1 when doxorubicin and vincristine were used singly or together, so specific kinase inhibitors may be useful in reducing inflammation in patients receiving chemotherapy.	Vincristine	200-211	interleukin 1 beta	Homo sapiens	153-161
25151996-0	2014	Caffeic acid phenethyl ester inhibits the inflammatory effects of interleukin-1beta in human corneal fibroblasts.	caffeic acid phenethyl ester	0-28	interleukin 1 beta	Homo sapiens	66-83
25109693-12	2014	IFN-gamma correlated positively with T-regs but negatively with IL-1beta (P = 0.041&amp;0.046 respectively), which correlated positively with T-effs%( P = 0.05).	Adenosine Monophosphate	84-87	interleukin 1 beta	Homo sapiens	64-72
25151996-6	2014	RESULTS: CAPE inhibited the expression of IL-6, MCP-1 and ICAM-1 induced by the pro-inflammatory cytokine IL-1beta in corneal fibroblasts.	caffeic acid phenethyl ester	9-13	interleukin 1 beta	Homo sapiens	106-114
25151996-7	2014	The activation of AKT and NF-kappaB by IL-1beta was markedly inhibited by CAPE, whereas the activity of mitogen-activated protein kinases (MAPKs) was not affected.	caffeic acid phenethyl ester	74-78	interleukin 1 beta	Homo sapiens	39-47
25151996-8	2014	CAPE significantly suppressed the IL-1beta-induced migration of differentiated (d)HL-60 and THP-1 cells.	caffeic acid phenethyl ester	0-4	interleukin 1 beta	Homo sapiens	34-42
24752615-0	2014	Bufalin exerts inhibitory effects on IL-1beta-mediated proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.	bufalin	0-7	interleukin 1 beta	Homo sapiens	37-45
24149798-5	2014	We examined the possibility that cis- and trans-resveratrol may affect cytokine secretion by modulating inflammasomes, intracellular multi-protein complexes, the assembly of which leads to caspase-1 activation and secretion of active IL-1beta by macrophages.	cis- and trans-resveratrol	33-59	interleukin 1 beta	Homo sapiens	234-242
24149798-6	2014	Our results show that pre-treatment of macrophages with cis-resveratrol not only reduces pro-IL-1beta production and IL-1beta secretion, but also suppresses ATP-induced transcription and activation of caspase-1 and caspase-4.	Resveratrol	56-71	interleukin 1 beta	Homo sapiens	93-101
24149798-6	2014	Our results show that pre-treatment of macrophages with cis-resveratrol not only reduces pro-IL-1beta production and IL-1beta secretion, but also suppresses ATP-induced transcription and activation of caspase-1 and caspase-4.	Resveratrol	56-71	interleukin 1 beta	Homo sapiens	117-125
24622777-6	2014	Data showed rutin was a potent inhibitor of PMA, TNF-alpha, IL-1beta, and CLP-induced EPCR shedding by suppression of TACE expression.	Rutin	12-17	interleukin 1 beta	Homo sapiens	60-68
24671668-0	2014	Sulforaphane inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2.	sulforaphane	0-12	interleukin 1 beta	Homo sapiens	22-30
24671668-0	2014	Sulforaphane inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2.	Dinoprostone	137-141	interleukin 1 beta	Homo sapiens	22-30
24671668-1	2014	This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs.	sulforaphane	50-62	interleukin 1 beta	Homo sapiens	66-83
24671668-1	2014	This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs.	sulforaphane	50-62	interleukin 1 beta	Homo sapiens	85-93
24671668-1	2014	This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs.	Dinoprostone	270-286	interleukin 1 beta	Homo sapiens	66-83
24671668-1	2014	This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs.	Dinoprostone	270-286	interleukin 1 beta	Homo sapiens	85-93
24671668-1	2014	This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs.	Dinoprostone	288-292	interleukin 1 beta	Homo sapiens	66-83
24671668-1	2014	This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs.	Dinoprostone	288-292	interleukin 1 beta	Homo sapiens	85-93
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	sulforaphane	0-12	interleukin 1 beta	Homo sapiens	39-47
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	sulforaphane	0-12	interleukin 1 beta	Homo sapiens	175-183
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	Dinoprostone	148-152	interleukin 1 beta	Homo sapiens	39-47
24752615-3	2014	In this study, we explored the effects of bufalin on interleukin-1beta (IL-1beta)-induced proliferation and apoptosis of RAFLSs.	bufalin	42-49	interleukin 1 beta	Homo sapiens	53-70
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	Dinoprostone	148-152	interleukin 1 beta	Homo sapiens	175-183
24752615-3	2014	In this study, we explored the effects of bufalin on interleukin-1beta (IL-1beta)-induced proliferation and apoptosis of RAFLSs.	bufalin	42-49	interleukin 1 beta	Homo sapiens	72-80
24671668-5	2014	Sulforaphane also inhibits the phosphorylation of ERK-1/2, p-38, and JNK and activation of NF-kB by IL-1beta.	sulforaphane	0-12	interleukin 1 beta	Homo sapiens	100-108
25048991-0	2014	NLRP3 inflammasome activation and interleukin-1beta release in macrophages require calcium but are independent of calcium-activated NADPH oxidases.	Calcium	83-90	interleukin 1 beta	Homo sapiens	34-51
24752615-5	2014	Bufalin dose-dependently inhibited IL-1beta-induced RAFLS proliferation.	bufalin	0-7	interleukin 1 beta	Homo sapiens	35-43
25048991-11	2014	RESULTS: Our data show that calcium is essential for IL-1beta release in human macrophages.	Calcium	28-35	interleukin 1 beta	Homo sapiens	53-61
24752615-6	2014	Mechanistically, bufalin decreased the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappaB), both of which are involved in IL-1beta-mediated RAFLS proliferation.	bufalin	17-24	interleukin 1 beta	Homo sapiens	165-173
25048991-12	2014	Increases in cytosolic calcium alone lead to IL-1beta secretion.	Calcium	23-30	interleukin 1 beta	Homo sapiens	45-53
25048991-16	2014	CONCLUSIONS: Human macrophage inflammasome activation and IL-1beta secretion requires calcium but does not involve NADPH oxidases.	Calcium	86-93	interleukin 1 beta	Homo sapiens	58-66
24752615-8	2014	Collectively, our results reveal that bufalin suppresses IL-1beta-induced proliferation of RAFLSs through MAPK and NF-kappaB signaling pathways and induces RAFLS apoptosis via the mitochondria-dependent pathway.	bufalin	38-45	interleukin 1 beta	Homo sapiens	57-65
25218171-6	2014	DSCR1 transfection-induced changes were increased by treatment with IL-1beta, which was suppressed by NAC and BAPTA.	Acetylcysteine	102-105	interleukin 1 beta	Homo sapiens	68-76
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Calcium	171-178	interleukin 1 beta	Homo sapiens	137-145
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Calcium	171-178	interleukin 1 beta	Homo sapiens	152-160
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Reactive Oxygen Species	183-186	interleukin 1 beta	Homo sapiens	137-145
25218171-6	2014	DSCR1 transfection-induced changes were increased by treatment with IL-1beta, which was suppressed by NAC and BAPTA.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	110-115	interleukin 1 beta	Homo sapiens	68-76
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Reactive Oxygen Species	15-18	interleukin 1 beta	Homo sapiens	137-145
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Reactive Oxygen Species	15-18	interleukin 1 beta	Homo sapiens	152-160
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Calcium	89-96	interleukin 1 beta	Homo sapiens	137-145
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Reactive Oxygen Species	183-186	interleukin 1 beta	Homo sapiens	152-160
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Calcium	89-96	interleukin 1 beta	Homo sapiens	152-160
25109475-10	2014	Furthermore, valsartan reduced inflammatory cytokine (TNF-alpha, IL-6 and IL-1beta) production and NF-kappaB activity in HG-activated THP-1 cells.	Valsartan	13-22	interleukin 1 beta	Homo sapiens	74-82
25587326-7	2014	In addition, LCE also decreased the TNF-alpha, IL-1beta and IL-6 levels in UVB-irradiated HaCaT cells.	LCE	13-16	interleukin 1 beta	Homo sapiens	47-55
24219423-2	2014	It is also proposed to combine with the P2X7 receptor, forming a complex involved in adenosine triphosphate (ATP)-induced interleukin-1beta (IL-1beta) release in macrophages.	Adenosine Triphosphate	85-107	interleukin 1 beta	Homo sapiens	122-139
24219423-5	2014	MATERIAL AND METHODS: Cultured HPDL cells were treated with compressive loading or ATP to stimulate IL-1beta expression.	Adenosine Triphosphate	83-86	interleukin 1 beta	Homo sapiens	100-108
24219423-2	2014	It is also proposed to combine with the P2X7 receptor, forming a complex involved in adenosine triphosphate (ATP)-induced interleukin-1beta (IL-1beta) release in macrophages.	Adenosine Triphosphate	85-107	interleukin 1 beta	Homo sapiens	141-149
24219423-9	2014	RESULTS: Blocking Panx1 significantly decreased ATP release, as well as IL-1beta up-regulation, upon stimulation with stress or ATP.	Adenosine Triphosphate	128-131	interleukin 1 beta	Homo sapiens	72-80
25077524-6	2014	Next we studied the effect of in vivo administration of NaHS in a model of interleukin-1beta (IL-1beta)-induced mesenteric inflammation.	sodium bisulfide	56-60	interleukin 1 beta	Homo sapiens	75-92
24219423-2	2014	It is also proposed to combine with the P2X7 receptor, forming a complex involved in adenosine triphosphate (ATP)-induced interleukin-1beta (IL-1beta) release in macrophages.	Adenosine Triphosphate	109-112	interleukin 1 beta	Homo sapiens	122-139
24219423-2	2014	It is also proposed to combine with the P2X7 receptor, forming a complex involved in adenosine triphosphate (ATP)-induced interleukin-1beta (IL-1beta) release in macrophages.	Adenosine Triphosphate	109-112	interleukin 1 beta	Homo sapiens	141-149
24219423-3	2014	Previously, we reported that mechanical stress induced IL-1beta expression via the ATP/P2X7 receptor-dependent pathway in human periodontal ligament (HPDL) cells and that ATP was released through the connexin 43 (Cx43) hemichannel.	Adenosine Triphosphate	83-86	interleukin 1 beta	Homo sapiens	55-63
25266361-9	2014	Maximal PGE2 release involved IL-1beta priming of MSCs after close contact between the NK cells and UC-MSCs.	Dinoprostone	8-12	interleukin 1 beta	Homo sapiens	30-38
24703401-4	2014	Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation.	bcp	115-118	interleukin 1 beta	Homo sapiens	139-146
24703401-4	2014	Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation.	Uric Acid	63-79	interleukin 1 beta	Homo sapiens	139-146
24703401-4	2014	Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation.	Uric Acid	81-84	interleukin 1 beta	Homo sapiens	139-146
24703401-4	2014	Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation.	basic calcium phosphate	90-113	interleukin 1 beta	Homo sapiens	139-146
25271853-8	2014	Addition of IL-6 to the same cells after stimulation with poly(I-C), CpG, Pam2CSK4, and MDP induced a significant increase in IL-1beta and CXCL8, but not TNF-alpha production compared with TLR ligands alone.	Poly I-C	58-67	interleukin 1 beta	Homo sapiens	126-134
24975507-5	2014	In this study, we found that alpha-LA inhibits the IL-1beta-induced increase in matrix metallopeptidase 3 (MMP-3) and matrix metallopeptidase 13 (MMP-13) expression and activity.	Thioctic Acid	29-37	interleukin 1 beta	Homo sapiens	51-59
25225402-4	2014	We found that heme, but not porphyrins without iron, activated LPS-primed macrophages promoting the processing of IL-1beta dependent on nucleotide-binding domain and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3).	Heme	14-18	interleukin 1 beta	Homo sapiens	114-122
25400736-0	2014	Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro study.	cordycepin	0-10	interleukin 1 beta	Homo sapiens	67-84
25751962-2	2014	Under pathological conditions, active oxygen species (O2-*2, etc) were used to induce endo- thelial dysfunction, activate NF-kappaB to induce expressions of pro-inflammatory cytokines IL-1beta and TNF-alpha, increase ET-1, TXA2 with vasoconstrictor effect, reduce PGI2 and NO with vasodilatory effect, generate further oxidative damage together with NO, and reduce the bioavailability of NO.	Oxygen	38-44	interleukin 1 beta	Homo sapiens	184-192
25751962-2	2014	Under pathological conditions, active oxygen species (O2-*2, etc) were used to induce endo- thelial dysfunction, activate NF-kappaB to induce expressions of pro-inflammatory cytokines IL-1beta and TNF-alpha, increase ET-1, TXA2 with vasoconstrictor effect, reduce PGI2 and NO with vasodilatory effect, generate further oxidative damage together with NO, and reduce the bioavailability of NO.	Oxygen	54-56	interleukin 1 beta	Homo sapiens	184-192
25181346-0	2014	High-temperature calcined fullerene nanowhiskers as well as long needle-like multi-wall carbon nanotubes have abilities to induce NLRP3-mediated IL-1beta secretion.	Fullerenes	26-35	interleukin 1 beta	Homo sapiens	145-153
25181346-0	2014	High-temperature calcined fullerene nanowhiskers as well as long needle-like multi-wall carbon nanotubes have abilities to induce NLRP3-mediated IL-1beta secretion.	Carbon	88-94	interleukin 1 beta	Homo sapiens	145-153
25181346-3	2014	In this study, we employed high-temperature calcined fullerene nanowhiskers (HTCFNWs), which are needle-like nanofibers composed of amorphous carbon having similar sizes to MWCNTs but neither metal impurities nor tubular structures, and investigated their ability to induce production a major proinflammatory cytokine IL-1beta via the Nod-like receptor pyrin domain containing 3 (NLRP3)-containing flammasome-mediated mechanism.	Fullerenes	53-62	interleukin 1 beta	Homo sapiens	318-326
25181346-5	2014	IL-1beta release induced by long-HTCFNW as well as by long, needle-like MWCNTs was abolished by a caspase-1 inhibitor or siRNA-knockdown of NLRP3, indicating that NLRP3-inflammasome-mediated IL-1beta production by these carbon nanofibers.	Carbon	220-226	interleukin 1 beta	Homo sapiens	0-8
25352747-0	2014	Effects of 5-aza-2"-deoxycytidine and trichostatin A on high glucose- and interleukin-1beta-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells.	Decitabine	11-33	interleukin 1 beta	Homo sapiens	74-91
25352747-0	2014	Effects of 5-aza-2"-deoxycytidine and trichostatin A on high glucose- and interleukin-1beta-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells.	trichostatin A	38-52	interleukin 1 beta	Homo sapiens	74-91
25352747-1	2014	PURPOSE: We aimed to elucidate the effects of two epigenetic inhibitors, 5-aza-2"-deoxycytidine (5-aza-dC) and trichostatin A (TSA), on several key secretory mediators of diabetic retinopathy (DR) in human retinal endothelial cells (HRECs) and human retinal pigment epithelial (HRPE) cells treated with high glucose or interleukin-1beta (IL-1beta).	Decitabine	73-95	interleukin 1 beta	Homo sapiens	319-336
25352747-1	2014	PURPOSE: We aimed to elucidate the effects of two epigenetic inhibitors, 5-aza-2"-deoxycytidine (5-aza-dC) and trichostatin A (TSA), on several key secretory mediators of diabetic retinopathy (DR) in human retinal endothelial cells (HRECs) and human retinal pigment epithelial (HRPE) cells treated with high glucose or interleukin-1beta (IL-1beta).	Decitabine	73-95	interleukin 1 beta	Homo sapiens	338-346
25352747-1	2014	PURPOSE: We aimed to elucidate the effects of two epigenetic inhibitors, 5-aza-2"-deoxycytidine (5-aza-dC) and trichostatin A (TSA), on several key secretory mediators of diabetic retinopathy (DR) in human retinal endothelial cells (HRECs) and human retinal pigment epithelial (HRPE) cells treated with high glucose or interleukin-1beta (IL-1beta).	Decitabine	97-105	interleukin 1 beta	Homo sapiens	319-336
25352747-1	2014	PURPOSE: We aimed to elucidate the effects of two epigenetic inhibitors, 5-aza-2"-deoxycytidine (5-aza-dC) and trichostatin A (TSA), on several key secretory mediators of diabetic retinopathy (DR) in human retinal endothelial cells (HRECs) and human retinal pigment epithelial (HRPE) cells treated with high glucose or interleukin-1beta (IL-1beta).	Decitabine	97-105	interleukin 1 beta	Homo sapiens	338-346
25352747-1	2014	PURPOSE: We aimed to elucidate the effects of two epigenetic inhibitors, 5-aza-2"-deoxycytidine (5-aza-dC) and trichostatin A (TSA), on several key secretory mediators of diabetic retinopathy (DR) in human retinal endothelial cells (HRECs) and human retinal pigment epithelial (HRPE) cells treated with high glucose or interleukin-1beta (IL-1beta).	trichostatin A	111-125	interleukin 1 beta	Homo sapiens	319-336
25352747-1	2014	PURPOSE: We aimed to elucidate the effects of two epigenetic inhibitors, 5-aza-2"-deoxycytidine (5-aza-dC) and trichostatin A (TSA), on several key secretory mediators of diabetic retinopathy (DR) in human retinal endothelial cells (HRECs) and human retinal pigment epithelial (HRPE) cells treated with high glucose or interleukin-1beta (IL-1beta).	trichostatin A	111-125	interleukin 1 beta	Homo sapiens	338-346
25352747-1	2014	PURPOSE: We aimed to elucidate the effects of two epigenetic inhibitors, 5-aza-2"-deoxycytidine (5-aza-dC) and trichostatin A (TSA), on several key secretory mediators of diabetic retinopathy (DR) in human retinal endothelial cells (HRECs) and human retinal pigment epithelial (HRPE) cells treated with high glucose or interleukin-1beta (IL-1beta).	trichostatin A	127-130	interleukin 1 beta	Homo sapiens	319-336
25352747-1	2014	PURPOSE: We aimed to elucidate the effects of two epigenetic inhibitors, 5-aza-2"-deoxycytidine (5-aza-dC) and trichostatin A (TSA), on several key secretory mediators of diabetic retinopathy (DR) in human retinal endothelial cells (HRECs) and human retinal pigment epithelial (HRPE) cells treated with high glucose or interleukin-1beta (IL-1beta).	trichostatin A	127-130	interleukin 1 beta	Homo sapiens	338-346
25352747-4	2014	RESULTS: In the 30 mM D-glucose and the 10 ng/ml IL-1beta condition, the expression of VEGF, ICAM-1, IL-1beta, and MMP2 was induced in the HRECs and the HRPE cells.	Glucose	22-31	interleukin 1 beta	Homo sapiens	101-109
25352747-7	2014	5-aza-dC dose-dependently alleviated VEGF, ICAM-1, IL-1beta, and MMP2 and reversed PEDF or the PEDF/VEGF ratio in both cell types.	Azacitidine	0-5	interleukin 1 beta	Homo sapiens	51-59
25234616-9	2014	The immunomodulatory effects of BAP were confirmed by lower levels of IL-1beta, IL-8, and a lower WBC count in the supplemented group in comparison with the control group.	benzylaminopurine	32-35	interleukin 1 beta	Homo sapiens	70-78
25261974-8	2014	Induction of IL-1beta by MSU was fully inhibited by a caspase-1 inhibitor confirming inflammasome activation as the mechanism for generating this cytokine.	Uric Acid	25-28	interleukin 1 beta	Homo sapiens	13-21
25261974-9	2014	In a dose-dependent manner, CS significantly inhibited IL-1beta (p = 0.003), and TNFalpha (p = 0.02) production from macrophages in response to MSU.	Chondroitin Sulfates	28-30	interleukin 1 beta	Homo sapiens	55-63
25238390-8	2014	In human fetal membranes and myometrium, nobiletin significantly decreased LPS-stimulated expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-8) and MMP-9 expression and pro-MMP-9 secretion.	nobiletin	41-50	interleukin 1 beta	Homo sapiens	143-151
25400736-3	2014	In the present study, we examined the inhibitory effects of cordycepin on interleukin-1 beta (IL-1beta)-induced glycosaminoglycan (GAG) release, nitric oxide production as well as gene expressions of inflammatory and catabolic mediators in human cartilage and chondrocytes.	cordycepin	60-70	interleukin 1 beta	Homo sapiens	74-92
25400736-3	2014	In the present study, we examined the inhibitory effects of cordycepin on interleukin-1 beta (IL-1beta)-induced glycosaminoglycan (GAG) release, nitric oxide production as well as gene expressions of inflammatory and catabolic mediators in human cartilage and chondrocytes.	cordycepin	60-70	interleukin 1 beta	Homo sapiens	94-102
25400736-3	2014	In the present study, we examined the inhibitory effects of cordycepin on interleukin-1 beta (IL-1beta)-induced glycosaminoglycan (GAG) release, nitric oxide production as well as gene expressions of inflammatory and catabolic mediators in human cartilage and chondrocytes.	Glycosaminoglycans	112-129	interleukin 1 beta	Homo sapiens	74-92
25400736-3	2014	In the present study, we examined the inhibitory effects of cordycepin on interleukin-1 beta (IL-1beta)-induced glycosaminoglycan (GAG) release, nitric oxide production as well as gene expressions of inflammatory and catabolic mediators in human cartilage and chondrocytes.	Glycosaminoglycans	112-129	interleukin 1 beta	Homo sapiens	94-102
25400736-8	2014	We found that cordycepin suppressed IL-1beta-stimulated GAG release.	cordycepin	14-24	interleukin 1 beta	Homo sapiens	36-44
25400736-8	2014	We found that cordycepin suppressed IL-1beta-stimulated GAG release.	Glycosaminoglycans	56-59	interleukin 1 beta	Homo sapiens	36-44
25400736-10	2014	In addition, cordycepin inhibited IL-1beta-induced COX-2 and iNOS expression at the transcript level as well as blocked NO production.	cordycepin	13-23	interleukin 1 beta	Homo sapiens	34-42
24786829-8	2014	Mechanistically, cytokines such as TGFbeta and IL1beta could activate PKClambda/iota signaling in TNBC cells and depletion of PKClambda/iota impairs NF-kappaB p65 (RelA) nuclear localization.	iota	80-84	interleukin 1 beta	Homo sapiens	47-54
25216247-8	2014	RESULTS: ALD coating of MWCNTs with Al2O3 enhanced IL-1beta secretion by THP-1 and PBMC in vitro, yet reduced protein levels of IL-6, TNF-alpha, and OPN production by THP-1 cells.	Aluminum Oxide	36-41	interleukin 1 beta	Homo sapiens	51-59
24786833-8	2014	In contrast, SAG-overexpressing macrophages challenged with PAMPs exhibited upregulation of protumorigenic cytokines (IL-1beta, IL-6 and TNF-alpha), and downregulation of antitumorigenic cytokine (IL-12p40) and anti-inflammatory cytokine (IL-10).	sagopilone	13-16	interleukin 1 beta	Homo sapiens	118-126
25128276-7	2014	ALO attenuated CCI induced up-regulation of expressions of NF-kappaB, TNF-alpha, IL-6, IL-1beta at the dose of 80mg/kg (i.p.).	aloperine	0-3	interleukin 1 beta	Homo sapiens	87-95
25128276-7	2014	ALO attenuated CCI induced up-regulation of expressions of NF-kappaB, TNF-alpha, IL-6, IL-1beta at the dose of 80mg/kg (i.p.).	CCI	15-18	interleukin 1 beta	Homo sapiens	87-95
25228902-7	2014	In M1 macrophages, the Krebs cycle intermediate succinate regulates HIF1alpha, which is responsible for driving the sustained production of the pro-inflammatory cytokine IL1beta.	krebs	23-28	interleukin 1 beta	Homo sapiens	170-177
25228902-7	2014	In M1 macrophages, the Krebs cycle intermediate succinate regulates HIF1alpha, which is responsible for driving the sustained production of the pro-inflammatory cytokine IL1beta.	Succinic Acid	48-57	interleukin 1 beta	Homo sapiens	170-177
24958470-6	2014	Overall, IL-1beta upregulated Lin28B by downregulating miR-101.	mir-101	55-62	interleukin 1 beta	Homo sapiens	9-17
24958470-7	2014	Interestingly, cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1beta-mediated repression of miR-101 and IL-1beta-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration.	Aspirin	46-53	interleukin 1 beta	Homo sapiens	77-85
24958470-7	2014	Interestingly, cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1beta-mediated repression of miR-101 and IL-1beta-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration.	Aspirin	46-53	interleukin 1 beta	Homo sapiens	121-129
24958470-7	2014	Interestingly, cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1beta-mediated repression of miR-101 and IL-1beta-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration.	Celecoxib	57-66	interleukin 1 beta	Homo sapiens	77-85
24958470-7	2014	Interestingly, cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1beta-mediated repression of miR-101 and IL-1beta-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration.	Celecoxib	57-66	interleukin 1 beta	Homo sapiens	121-129
24958470-7	2014	Interestingly, cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1beta-mediated repression of miR-101 and IL-1beta-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration.	mir-101	109-116	interleukin 1 beta	Homo sapiens	77-85
24958470-8	2014	Together, our findings defined an IL-1beta-miR-101-Lin28B pathway as a novel regulatory axis of pathogenic inflammatory signaling in NSCLC.	mir-101	43-50	interleukin 1 beta	Homo sapiens	34-42
25177432-0	2014	Dexamethasone inhibits interleukin-1beta-induced matrix metalloproteinase-9 expression in cochlear cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	23-40
25177432-1	2014	OBJECTIVES: To investigate the effect of interleukin (IL)-1beta on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1beta-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved.	Dexamethasone	178-191	interleukin 1 beta	Homo sapiens	140-148
25177432-7	2014	IL-1beta (1 ng/mL)-induced MMP-9 expression was inhibited by dexamethasone.	Dexamethasone	61-74	interleukin 1 beta	Homo sapiens	0-8
25177432-8	2014	Interestingly, p38 MAPK inhibitor, SB203580, significantly inhibited IL-1beta-induced MMP-9 mRNA and MMP-9 activity.	SB 203580	35-43	interleukin 1 beta	Homo sapiens	69-77
25177432-10	2014	CONCLUSION: These results suggest that the pro-inflammatory cytokine IL-1beta strongly induces MMP-9 expression via activation of p38 MAPK signaling pathway in HEI-OC1 cells and the induction was inhibited by dexamethasone.	Dexamethasone	209-222	interleukin 1 beta	Homo sapiens	69-77
25103574-7	2014	The enrichment of H3K4me2 marks was 11-137 % greater in riboflavin-deficient cells compared with sufficient cells in exon 1 of genes coding for the pro-inflammatory cytokines interleukin (IL)-1alpha, IL-1beta, IL-6, and tumor necrosis factor-alpha.	Riboflavin	56-66	interleukin 1 beta	Homo sapiens	200-208
24975660-6	2014	RESULTS: We found a significant reduction of IL-1beta induced PGE2, 8-iso-PGF2beta and IL-6 chondrocytes by 5-HT(3)RA especially by dolasetron.	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	45-53
24947163-0	2014	Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1beta, IL-6 and IL-10 on human macrophages.	alpha-terpineol	18-33	interleukin 1 beta	Homo sapiens	86-94
24947163-0	2014	Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1beta, IL-6 and IL-10 on human macrophages.	terpinenol-4	0-13	interleukin 1 beta	Homo sapiens	86-94
24975660-6	2014	RESULTS: We found a significant reduction of IL-1beta induced PGE2, 8-iso-PGF2beta and IL-6 chondrocytes by 5-HT(3)RA especially by dolasetron.	8-isoprostaglandin PGF2beta	68-82	interleukin 1 beta	Homo sapiens	45-53
24975660-6	2014	RESULTS: We found a significant reduction of IL-1beta induced PGE2, 8-iso-PGF2beta and IL-6 chondrocytes by 5-HT(3)RA especially by dolasetron.	dolasetron	132-142	interleukin 1 beta	Homo sapiens	45-53
24501112-5	2014	METHODS: Prostanoids produced by human oral keratinocytes (HOK) stimulated with IL-1beta were measured by enzyme immunoassay.	Prostaglandins	9-20	interleukin 1 beta	Homo sapiens	80-88
25091058-0	2014	Th17 can regulate silica-induced lung inflammation through an IL-1beta-dependent mechanism.	Silicon Dioxide	18-24	interleukin 1 beta	Homo sapiens	62-70
25091058-2	2014	Interleukin (IL)-1beta is induced by silica and functions as the key pro-inflammatory cytokine in this process.	Silicon Dioxide	37-43	interleukin 1 beta	Homo sapiens	0-22
25091058-5	2014	We observed increased IL-1beta expression and an enhanced Th17 response after silica instillation.	Silicon Dioxide	78-84	interleukin 1 beta	Homo sapiens	22-30
25091058-9	2014	Silica may induce IL-1beta production from alveolar macrophages and promote inflammation by initiating a Th17 response via an IL-1beta/IL-1RI-dependent mechanism.	Silicon Dioxide	0-6	interleukin 1 beta	Homo sapiens	18-26
25091058-9	2014	Silica may induce IL-1beta production from alveolar macrophages and promote inflammation by initiating a Th17 response via an IL-1beta/IL-1RI-dependent mechanism.	Silicon Dioxide	0-6	interleukin 1 beta	Homo sapiens	126-134
24488604-3	2014	In this study, TC was found to significantly inhibit hypoxia-induced cytotoxicity as well as the release of proinflammatory cytokines, including IL-1beta, TNF-alpha, and IL-6, through activation of BV2 microglia following hypoxic exposure (1 % O2, 24 h).	caryophyllene	15-17	interleukin 1 beta	Homo sapiens	145-153
24925806-6	2014	While several inhibitors are available for caspase-1 blocking experiments, in this study we show effects of two commonly used caspase inhibitors: z-VAD-fmk and ac-YVAD-cmk on secretion of pro-inflammatory cytokines: IL-1beta, TNFalpha, IL-8 and IL-6 in whole blood stimulated with LPS.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	146-155	interleukin 1 beta	Homo sapiens	216-224
24925806-6	2014	While several inhibitors are available for caspase-1 blocking experiments, in this study we show effects of two commonly used caspase inhibitors: z-VAD-fmk and ac-YVAD-cmk on secretion of pro-inflammatory cytokines: IL-1beta, TNFalpha, IL-8 and IL-6 in whole blood stimulated with LPS.	ac-yvad	160-167	interleukin 1 beta	Homo sapiens	216-224
24925806-7	2014	We demonstrate ac-YVAD-cmk is a specific caspase-1 inhibitor resulting in pronounced decreases in IL-1beta and less suppression of TNFalpha, IL-6 and IL-8, while pan-caspase inhibitor, z-VAD-fmk, only weakly suppressed Il-1beta while acting strongly on the other three cytokines.	ac-yvad	15-22	interleukin 1 beta	Homo sapiens	98-106
24925806-7	2014	We demonstrate ac-YVAD-cmk is a specific caspase-1 inhibitor resulting in pronounced decreases in IL-1beta and less suppression of TNFalpha, IL-6 and IL-8, while pan-caspase inhibitor, z-VAD-fmk, only weakly suppressed Il-1beta while acting strongly on the other three cytokines.	ac-yvad	15-22	interleukin 1 beta	Homo sapiens	219-227
25228841-7	2014	RESULTS: SKI306X and PV inhibited IL-1beta-induced GAG release from cartilage explants, and SKI306X, CM, PV, and TK inhibited IL-1beta-induced MMP gene expression.	Glycosaminoglycans	51-54	interleukin 1 beta	Homo sapiens	34-42
25229432-4	2014	TNF-alpha or IL-1beta induced significant increases in the permeability to 4 and 12 kDa dextrans.	Dextrans	88-96	interleukin 1 beta	Homo sapiens	13-21
25229432-8	2014	TNF-alpha or IL-1beta caused significant increases in ERK 1/2 phosphorylation in the LEC, which were significantly inhibited by Y-27632 or PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	139-146	interleukin 1 beta	Homo sapiens	13-21
25229432-6	2014	Pretreatment with Y-27632, a Rho kinase inhibitor, or PD98059, an extracellular signal-regulated kinase (ERK) phosphorylation inhibitor, significantly abolished the TNF-alpha- or IL-1beta-induced increases in the permeability of the layers to 4 and 12 kDa dextrans.	Y 27632	18-25	interleukin 1 beta	Homo sapiens	179-187
25229432-9	2014	These findings suggest that the human LEC layer plays key roles in the transport of hydrophilic substances through collecting lymph vessel walls and that TNF-alpha or IL-1beta significantly increases the permeability of the layers to 4 and 12 kDa dextrans via Rho kinase activation and the ERK 1/2 phosphorylation-mediated reorganization of F-actin in the LEC.	Dextrans	247-255	interleukin 1 beta	Homo sapiens	167-175
25229432-6	2014	Pretreatment with Y-27632, a Rho kinase inhibitor, or PD98059, an extracellular signal-regulated kinase (ERK) phosphorylation inhibitor, significantly abolished the TNF-alpha- or IL-1beta-induced increases in the permeability of the layers to 4 and 12 kDa dextrans.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	54-61	interleukin 1 beta	Homo sapiens	179-187
25229432-6	2014	Pretreatment with Y-27632, a Rho kinase inhibitor, or PD98059, an extracellular signal-regulated kinase (ERK) phosphorylation inhibitor, significantly abolished the TNF-alpha- or IL-1beta-induced increases in the permeability of the layers to 4 and 12 kDa dextrans.	Dextrans	256-264	interleukin 1 beta	Homo sapiens	179-187
25229432-7	2014	Y-27632 and PD98059 significantly inhibited the changes in the F-actin distribution of the LEC produced by TNF-alpha or IL-1beta.	Y 27632	0-7	interleukin 1 beta	Homo sapiens	120-128
25229432-7	2014	Y-27632 and PD98059 significantly inhibited the changes in the F-actin distribution of the LEC produced by TNF-alpha or IL-1beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	12-19	interleukin 1 beta	Homo sapiens	120-128
25229432-8	2014	TNF-alpha or IL-1beta caused significant increases in ERK 1/2 phosphorylation in the LEC, which were significantly inhibited by Y-27632 or PD98059.	Y 27632	128-135	interleukin 1 beta	Homo sapiens	13-21
25284569-9	2014	CONCLUSION: Phenytoin induced gingival fibroblasts of children produce more amounts of IL1beta, PGE2, IL6, TGFbeta and IL8 as compared to adults" fibroblasts.	Phenytoin	12-21	interleukin 1 beta	Homo sapiens	87-94
24951966-13	2014	Last, we showed that fluvastatin reduced the mRNA levels of pro-inflammatory molecules such as IL-1beta and MCP-1 in LPS-treated macrophages, which were completely reversed by CSE inhibitor PAG.	Fluvastatin	21-32	interleukin 1 beta	Homo sapiens	95-103
24951966-13	2014	Last, we showed that fluvastatin reduced the mRNA levels of pro-inflammatory molecules such as IL-1beta and MCP-1 in LPS-treated macrophages, which were completely reversed by CSE inhibitor PAG.	propargylglycine	190-193	interleukin 1 beta	Homo sapiens	95-103
24801508-9	2014	The combined use of rapamycin and resveratrol enhanced AMPK, thereby restoring downstream signaling and reducing IL1beta secretion.	Resveratrol	34-45	interleukin 1 beta	Homo sapiens	113-120
25044117-4	2014	In this study, we reported that cilostazol is able to suppress the degradation of type II collagen in human chondrocytes induced by IL-1beta.	Cilostazol	32-42	interleukin 1 beta	Homo sapiens	132-140
24329131-8	2014	Tofacitinib suppressed the IL-1beta-induced alteration in 4 (9.3%) out of the 43 spots.	tofacitinib	0-11	interleukin 1 beta	Homo sapiens	27-35
24329131-9	2014	The production of AMP deaminase 2 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 were increased by IL-1beta and the increase was suppressed by SSZ and by tofacitinib.	tofacitinib	162-173	interleukin 1 beta	Homo sapiens	107-115
24329131-11	2014	CONCLUSION: SSZ and, to lesser extent, tofacitinib suppress the effects of IL-1beta on the protein profiles of chondrocytes.	tofacitinib	39-50	interleukin 1 beta	Homo sapiens	75-83
25075866-7	2014	Only the anthocyanin-rich fraction reduced the activation of NF-kappaB, induced by IL-1beta in intestinal epithelial Caco-2 cells.	Anthocyanins	9-20	interleukin 1 beta	Homo sapiens	83-91
24996056-2	2014	Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte.	Tetradecanoylphorbol Acetate	74-105	interleukin 1 beta	Homo sapiens	120-128
24996056-2	2014	Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte.	Tetradecanoylphorbol Acetate	107-110	interleukin 1 beta	Homo sapiens	120-128
25099355-4	2014	atRA prevents human nTregs from converting to Th1 and/or Th17 cells and sustains their Foxp3 expression and suppressive function in vitro or in vivo following encounters with IL-1 and IL-6.	Tretinoin	0-4	interleukin 1 beta	Homo sapiens	175-179
25099355-5	2014	Interestingly, adoptive transfer of human nTregs pretreated with atRA significantly enhanced their suppressive effects on xenograft-vs.-host diseases (xGVHDs), and atRA- but not rapamycin-pretreated nTregs sustained the functional activity against xGVHD after stimulation with IL-1/IL-6.	Tretinoin	65-69	interleukin 1 beta	Homo sapiens	277-281
25122505-4	2014	In addition, its effect on IL-1beta-induced prostaglandin E2 (PGE2) production by fibroblasts was determined.	Dinoprostone	44-60	interleukin 1 beta	Homo sapiens	27-35
25024384-6	2014	In vitro pre-exposure to moderate alcohol reduced subsequent LPS-induced NF-kappaB promoter activity and downstream TNF-alpha, IL-6 and IL-1beta production in monocytes and macrophages, exhibiting endotoxin tolerance.	Alcohols	34-41	interleukin 1 beta	Homo sapiens	136-144
25121926-8	2014	MbetaCD reduced membrane cholesterol in PBEos, and attenuated an IL-5-stimulated p38 and extracellular-regulated kinase 1/2 phosphorylation (p-p38, p-ERK1/2), and an IL-5-dependent increase in interleukin-1beta (IL-1beta) mRNA levels.	methyl-beta-cyclodextrin	0-7	interleukin 1 beta	Homo sapiens	193-210
25121926-8	2014	MbetaCD reduced membrane cholesterol in PBEos, and attenuated an IL-5-stimulated p38 and extracellular-regulated kinase 1/2 phosphorylation (p-p38, p-ERK1/2), and an IL-5-dependent increase in interleukin-1beta (IL-1beta) mRNA levels.	methyl-beta-cyclodextrin	0-7	interleukin 1 beta	Homo sapiens	212-220
25122505-4	2014	In addition, its effect on IL-1beta-induced prostaglandin E2 (PGE2) production by fibroblasts was determined.	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	27-35
25122505-8	2014	It also inhibited IL-1beta-induced PGE2 production, but not COX-2 expression of fibroblasts.	Dinoprostone	35-39	interleukin 1 beta	Homo sapiens	18-26
25116125-5	2014	In ATRA-treated NB4 cells, celastrol could potently inhibit ICAM-1 elevation and partially reduce TNF-alpha and IL-1beta secretion, though treatment showed no effects on IL-8 and MCP-1 levels.	celastrol	27-36	interleukin 1 beta	Homo sapiens	112-120
24962570-5	2014	In contrast, the SIRT1 activator resveratrol or BMS-345541 (inhibitor of IKK) inhibited IL-1beta- and NAM-induced suppression of cartilage-specific proteins, Sox9, and up-regulation of NF-kappaB-regulated gene products.	Resveratrol	33-44	interleukin 1 beta	Homo sapiens	88-96
24962570-5	2014	In contrast, the SIRT1 activator resveratrol or BMS-345541 (inhibitor of IKK) inhibited IL-1beta- and NAM-induced suppression of cartilage-specific proteins, Sox9, and up-regulation of NF-kappaB-regulated gene products.	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	48-58	interleukin 1 beta	Homo sapiens	88-96
24962570-6	2014	Moreover, SIRT1 was found to interact directly with NF-kappaB and resveratrol-suppressed IL-1beta and NAM but not SIRT1-ASO-induced NF-kappaB phosphorylation, acetylation, and activation of IkappaBalpha kinase.	Resveratrol	66-77	interleukin 1 beta	Homo sapiens	89-97
24274595-7	2014	The association of SNPs in IL1B, IL1RN and IL15 with CCPA supports a role for the IL1 pathway, as well as implicating the IL15 gene, in susceptibility to CCPA.	2-chloro-N(6)cyclopentyladenosine	53-57	interleukin 1 beta	Homo sapiens	27-31
24880897-9	2014	However, treatment of inflammatory M1 macrophages with aspirin reduced secretion of the pro-inflammatory cytokines IL-1beta and IL-6, and increased secretion of the anti-inflammatory IL-10.	Aspirin	55-62	interleukin 1 beta	Homo sapiens	115-123
24894535-9	2014	Caspase-1-dependent IL-1beta secretion was impaired in monocytes from patients with AD compared to patients with psoriasis and healthy controls by alpha-toxin stimulation following priming with lipoteichoic acid.	lipoteichoic acid	194-211	interleukin 1 beta	Homo sapiens	20-28
24918199-12	2014	MC medium-inhibited expression of the adipogenic factors and -stimulated lipolysis was also blunted with IL-1beta neutralization.	mc medium	0-9	interleukin 1 beta	Homo sapiens	105-113
24811262-8	2014	Flavopiridol NPs significantly decreased inflammatory factor synthesis by astrocytes, including TNF-alpha, IL-1beta, and IL-6, while the IL-10 expression was elevated.	alvocidib	0-12	interleukin 1 beta	Homo sapiens	107-115
24726893-2	2014	We have previously shown that disruption of primary cilia assembly, through targeting intraflagellar transport, is associated with muted nitric oxide and prostaglandin responses to the inflammatory cytokine interleukin-1beta (IL-1beta).	Nitric Oxide	137-149	interleukin 1 beta	Homo sapiens	226-234
24726893-2	2014	We have previously shown that disruption of primary cilia assembly, through targeting intraflagellar transport, is associated with muted nitric oxide and prostaglandin responses to the inflammatory cytokine interleukin-1beta (IL-1beta).	Prostaglandins	154-167	interleukin 1 beta	Homo sapiens	226-234
23824148-6	2014	IL-1 alpha, IL-1beta and IL-6 levels were reduced by 1,25(OH) 2D3 at higher concentrations in all cell populations.	(oh) 2d3	57-65	interleukin 1 beta	Homo sapiens	12-20
24274595-5	2014	Compared with macrophages from healthy subjects, CCPA macrophages showed unrestrained rises in IL1A, IL1B, IL6, IRAK2 and TRAF6 throughout the experiment, and a lack of expression of TGFB1 at 9 h. Single nucleotide polymorphisms (SNPs) associated with CCPA were found in IL1B (n = 2), IL1RN and IL15 (n = 3).	2-chloro-N(6)cyclopentyladenosine	49-53	interleukin 1 beta	Homo sapiens	271-275
24274595-5	2014	Compared with macrophages from healthy subjects, CCPA macrophages showed unrestrained rises in IL1A, IL1B, IL6, IRAK2 and TRAF6 throughout the experiment, and a lack of expression of TGFB1 at 9 h. Single nucleotide polymorphisms (SNPs) associated with CCPA were found in IL1B (n = 2), IL1RN and IL15 (n = 3).	2-chloro-N(6)cyclopentyladenosine	49-53	interleukin 1 beta	Homo sapiens	101-105
24274595-7	2014	The association of SNPs in IL1B, IL1RN and IL15 with CCPA supports a role for the IL1 pathway, as well as implicating the IL15 gene, in susceptibility to CCPA.	2-chloro-N(6)cyclopentyladenosine	53-57	interleukin 1 beta	Homo sapiens	27-30
24274595-7	2014	The association of SNPs in IL1B, IL1RN and IL15 with CCPA supports a role for the IL1 pathway, as well as implicating the IL15 gene, in susceptibility to CCPA.	2-chloro-N(6)cyclopentyladenosine	154-158	interleukin 1 beta	Homo sapiens	27-30
24515724-7	2014	Furthermore, bufalin attenuated the TNF-alpha-induced interleukin-1beta (IL-1beta), IL-6, and IL-8 production in RAFLSs in a concentration-dependent manner.	bufalin	13-20	interleukin 1 beta	Homo sapiens	54-71
24858301-4	2014	RESULTS: HA/sorbitol prevented IL-1beta-induced oxidative stress, as measured by reactive oxygen species, p47-NADPH oxidase phosphorylation, 4-hydroxynonenal (HNE) production and HNE-metabolizing glutathione-S-transferase A4-4 expression.	Glutathione	196-207	interleukin 1 beta	Homo sapiens	31-39
24858301-5	2014	Moreover, HA/sorbitol stifled IL-1beta-induced metalloproteinase-13, nitric oxide (NO) and prostaglandin E2 release as well as inducible NO synthase expression.	Sorbitol	13-21	interleukin 1 beta	Homo sapiens	30-38
24858301-5	2014	Moreover, HA/sorbitol stifled IL-1beta-induced metalloproteinase-13, nitric oxide (NO) and prostaglandin E2 release as well as inducible NO synthase expression.	Nitric Oxide	69-81	interleukin 1 beta	Homo sapiens	30-38
24858301-5	2014	Moreover, HA/sorbitol stifled IL-1beta-induced metalloproteinase-13, nitric oxide (NO) and prostaglandin E2 release as well as inducible NO synthase expression.	Dinoprostone	91-107	interleukin 1 beta	Homo sapiens	30-38
24858301-7	2014	Examination of signaling pathway components disclosed that HA/sorbitol prevented IL-1beta-induced p38 mitogen-activated protein kinase and nuclear factor-kappa B activation, but not that of extracellular signal-regulated kinases 1 and 2.	histidinoalanine	59-61	interleukin 1 beta	Homo sapiens	81-89
24858301-7	2014	Examination of signaling pathway components disclosed that HA/sorbitol prevented IL-1beta-induced p38 mitogen-activated protein kinase and nuclear factor-kappa B activation, but not that of extracellular signal-regulated kinases 1 and 2.	Sorbitol	62-70	interleukin 1 beta	Homo sapiens	81-89
24807533-8	2014	Ebselen prevented the increased beta-cell apoptosis, possibly by decreasing IL-1beta and TNF-alpha in islets.	ebselen	0-7	interleukin 1 beta	Homo sapiens	76-84
24858301-4	2014	RESULTS: HA/sorbitol prevented IL-1beta-induced oxidative stress, as measured by reactive oxygen species, p47-NADPH oxidase phosphorylation, 4-hydroxynonenal (HNE) production and HNE-metabolizing glutathione-S-transferase A4-4 expression.	histidinoalanine	9-11	interleukin 1 beta	Homo sapiens	31-39
24858301-4	2014	RESULTS: HA/sorbitol prevented IL-1beta-induced oxidative stress, as measured by reactive oxygen species, p47-NADPH oxidase phosphorylation, 4-hydroxynonenal (HNE) production and HNE-metabolizing glutathione-S-transferase A4-4 expression.	Sorbitol	12-20	interleukin 1 beta	Homo sapiens	31-39
24515724-7	2014	Furthermore, bufalin attenuated the TNF-alpha-induced interleukin-1beta (IL-1beta), IL-6, and IL-8 production in RAFLSs in a concentration-dependent manner.	bufalin	13-20	interleukin 1 beta	Homo sapiens	73-81
24970858-16	2014	Significant adjusted differences were found between DHA and control for both gingival crevicular fluid hsCRP (-5.3 ng/mL, standard error [SE] = 2.4, p = .03) and IL-1beta (-20.1 pg/mL, SE = 8.2, p = .02) but not IL-6 (0.02 pg/mL, SE = 0.71, p = .98) or systemic hsCRP (-1.19 mg/L, SE = 0.90, p = .20).	Docosahexaenoic Acids	52-55	interleukin 1 beta	Homo sapiens	162-170
24859058-3	2014	Here, the anti-apoptotic and anti-catabolic effects of baicalein on human OA chondrocytes treated by a mixture of IL-1beta and TNF-alpha (IT) were investigated in vitro.	baicalein	55-64	interleukin 1 beta	Homo sapiens	114-122
24939850-6	2014	Furthermore, the lysosomal protease cathepsin B and HIV-1 induced production of reactive oxygen species were critical for HIV-induced inflammasome activation and IL-1beta production.	Reactive Oxygen Species	80-103	interleukin 1 beta	Homo sapiens	162-170
23947915-0	2014	Effect of adjunctive roxithromycin therapy on interleukin-1beta, transforming growth factor-beta1 and vascular endothelial growth factor in gingival crevicular fluid of cyclosporine A-treated patients with gingival overgrowth.	Roxithromycin	21-34	interleukin 1 beta	Homo sapiens	46-97
23952046-3	2014	Cranberry proanthocyanidins (PACs) inhibit IL-1beta-stimulated IL-6 production, but specific mechanisms are unclear.	Proanthocyanidins	10-27	interleukin 1 beta	Homo sapiens	43-51
23952046-3	2014	Cranberry proanthocyanidins (PACs) inhibit IL-1beta-stimulated IL-6 production, but specific mechanisms are unclear.	Proanthocyanidins	29-33	interleukin 1 beta	Homo sapiens	43-51
23952046-7	2014	Effects of NDM on IL-1beta-activated NF-kappaB and AP-1 and phosphorylated intermediates in both pathways were measured in cell extracts via binding to specific oligonucleotides and specific sandwich ELISAs, respectively.	Oligonucleotides	161-177	interleukin 1 beta	Homo sapiens	18-26
24607939-6	2014	Interestingly, liposomal dexamethasone induced proinflammatory cytokine secretion (specifically TNF, IL1beta, IL6) in unstimulated cells, but reduced this response under inflammatory conditions.	Dexamethasone	25-38	interleukin 1 beta	Homo sapiens	101-108
24650777-10	2014	The IL-1beta inhibitory antibody, canakinumab, was effective for the treatment of acute attacks in subjects refractory to and in those with contraindications to NSAIDs and/or colchicine.	Colchicine	175-185	interleukin 1 beta	Homo sapiens	4-12
24928317-8	2014	At day 7 of CIOA, already 6 h after ASC injection mRNA expression of pro-inflammatory mediators S100A8/A9, interleukin-1beta (IL-1beta) and KC was down-regulated in the synovium.	cioa	12-16	interleukin 1 beta	Homo sapiens	107-124
24928317-8	2014	At day 7 of CIOA, already 6 h after ASC injection mRNA expression of pro-inflammatory mediators S100A8/A9, interleukin-1beta (IL-1beta) and KC was down-regulated in the synovium.	cioa	12-16	interleukin 1 beta	Homo sapiens	126-134
24928317-8	2014	At day 7 of CIOA, already 6 h after ASC injection mRNA expression of pro-inflammatory mediators S100A8/A9, interleukin-1beta (IL-1beta) and KC was down-regulated in the synovium.	asc	36-39	interleukin 1 beta	Homo sapiens	107-124
24928317-8	2014	At day 7 of CIOA, already 6 h after ASC injection mRNA expression of pro-inflammatory mediators S100A8/A9, interleukin-1beta (IL-1beta) and KC was down-regulated in the synovium.	asc	36-39	interleukin 1 beta	Homo sapiens	126-134
25237378-13	2014	CONCLUSION: Vitamin D, 25(OH)D, and 1,25(OH)2D play a role in regulating human lung fibroblast functions in wound repair and tissue remodeling through not only inhibiting IL-1beta stimulated MMP-9 production and conversion to its active form but also inhibiting IL-1beta inhibition on TIMP-1 and TIMP-2 production.	Deuterium	20-21	interleukin 1 beta	Homo sapiens	171-179
25237378-13	2014	CONCLUSION: Vitamin D, 25(OH)D, and 1,25(OH)2D play a role in regulating human lung fibroblast functions in wound repair and tissue remodeling through not only inhibiting IL-1beta stimulated MMP-9 production and conversion to its active form but also inhibiting IL-1beta inhibition on TIMP-1 and TIMP-2 production.	Deuterium	20-21	interleukin 1 beta	Homo sapiens	262-270
25202950-6	2014	RESULTS: Compared with the THP-1 macrophages without palmitic acid, the level of ROS, NALP3 protein and caspase-1 protein, and the expression of IL-1beta were increased after palmitic acid treatment in a dose dependent manner (P&lt;0.05).	Palmitic Acid	175-188	interleukin 1 beta	Homo sapiens	145-153
24876379-3	2014	The ceramide-to-S1P pathway is also implicated in the development of pain, raising the intriguing possibility that these sphingolipids may contribute to chemotherapy- induced painful peripheral neuropathy, which can be a critical dose-limiting side effect of many widely used chemotherapeutic agents.We demonstrate that the development of paclitaxel-induced neuropathic pain was associated with ceramide and S1P formation in the spinal dorsal horn that corresponded with the engagement of S1P receptor subtype 1 (S1PR(1))- dependent neuroinflammatory processes as follows: activation of redox-sensitive transcription factors (NFkappaB) and MAPKs (ERK and p38) as well as enhanced formation of pro-inflammatory and neuroexcitatory cytokines (TNF-alpha and IL-1beta).	Sphingolipids	121-134	interleukin 1 beta	Homo sapiens	755-763
23953749-7	2014	FOXM1 silencing in primary amnion cells increased interleukin (IL)-1beta-induced pro-inflammatory cytokines (IL-6 and IL-8 mRNA expression and secretion), cyclooxygenase (COX)-2 expression and subsequent prostaglandin (PG)E2 and PGF2alpha release as well as gene expression and secretion of the matrix-degrading enzyme matrix metalloproteinase 9 (MMP-9).	Dinoprostone	204-224	interleukin 1 beta	Homo sapiens	50-72
23953749-7	2014	FOXM1 silencing in primary amnion cells increased interleukin (IL)-1beta-induced pro-inflammatory cytokines (IL-6 and IL-8 mRNA expression and secretion), cyclooxygenase (COX)-2 expression and subsequent prostaglandin (PG)E2 and PGF2alpha release as well as gene expression and secretion of the matrix-degrading enzyme matrix metalloproteinase 9 (MMP-9).	Dinoprost	229-238	interleukin 1 beta	Homo sapiens	50-72
25429809-11	2014	After CPFA was performed for the first time, the plasma levels of TNF-alpha, IL-1beta, and IL-6 from site D were significantly lower than those from site C before CPFA was performed for the first time (with t values respectively 5.48, 2.	cpfa	6-10	interleukin 1 beta	Homo sapiens	77-85
25429809-15	2014	The ratios of IL-1RA to IL-1beta and sTNFR-I plus sTNFR-II to TNF-alpha, and expression rate of HLA-DR were increased significantly after CPFA was performed for the second time as compared with those before CPFA (with t values from 3.99 to 7.	cpfa	138-142	interleukin 1 beta	Homo sapiens	24-32
24876379-3	2014	The ceramide-to-S1P pathway is also implicated in the development of pain, raising the intriguing possibility that these sphingolipids may contribute to chemotherapy- induced painful peripheral neuropathy, which can be a critical dose-limiting side effect of many widely used chemotherapeutic agents.We demonstrate that the development of paclitaxel-induced neuropathic pain was associated with ceramide and S1P formation in the spinal dorsal horn that corresponded with the engagement of S1P receptor subtype 1 (S1PR(1))- dependent neuroinflammatory processes as follows: activation of redox-sensitive transcription factors (NFkappaB) and MAPKs (ERK and p38) as well as enhanced formation of pro-inflammatory and neuroexcitatory cytokines (TNF-alpha and IL-1beta).	Ceramides	4-12	interleukin 1 beta	Homo sapiens	755-763
25067987-12	2014	CONCLUSIONS: Hypertonic saline has an immunomodulatory effect on polymorphonuclear cells through the TLR-4 pathway, and the interleukin-1beta-associated pathway is influenced more by hypertonic saline than is the tumor necrosis factor-alpha-associated pathway.	Sodium Chloride	194-200	interleukin 1 beta	Homo sapiens	124-141
25054228-13	2014	Glioblastoma IL-1beta processing occurred by the NLRP3 inflammasome, and ATP and nigericin increased IL-1beta processing by upregulating NLRP3 expression, similar to macrophages.	Adenosine Triphosphate	73-76	interleukin 1 beta	Homo sapiens	101-109
25054228-13	2014	Glioblastoma IL-1beta processing occurred by the NLRP3 inflammasome, and ATP and nigericin increased IL-1beta processing by upregulating NLRP3 expression, similar to macrophages.	Nigericin	81-90	interleukin 1 beta	Homo sapiens	101-109
24594225-6	2014	In macrophages, 17-oxo-DHA potently suppressed TNFalpha release in response to LPS, CSE and IL-1beta acting at transcriptional level via a mechanism independent of Nrf2.	(4Z,7Z,10Z,13Z,15E,19Z)-17-Oxodocosahexaenoic acid	16-26	interleukin 1 beta	Homo sapiens	92-100
25184735-6	2014	In this study we investigate the role of P2X7 channels and the ecto-5"-nucleotidase CD39 in ATP-triggered release of IL-1beta from LPS-treated mast cells.	Adenosine Triphosphate	92-95	interleukin 1 beta	Homo sapiens	117-125
25184735-11	2014	Intriguingly, stimulation with low ATP concentrations augmented the production of IL-1beta in LPS-primed MCs in a P2X7-independent but caspase-1-dependent manner.	Adenosine Triphosphate	35-38	interleukin 1 beta	Homo sapiens	82-90
24864079-3	2014	Promising clinical data for "upstream" biomarkers of inflammation such as interleukin-6 (IL-6) as well as "downstream" biomarkers such as C-reactive protein, observations regarding cholesterol crystals as an activator of the IL-1beta generating inflammasome, and recent Mendelian randomization data for the IL-6 receptor support the hypothesis that inflammatory mediators of atherosclerosis may converge on the central IL-1, tumour necrosis factor (TNF-alpha), IL-6 signalling pathway.	Cholesterol	181-192	interleukin 1 beta	Homo sapiens	225-233
24864079-3	2014	Promising clinical data for "upstream" biomarkers of inflammation such as interleukin-6 (IL-6) as well as "downstream" biomarkers such as C-reactive protein, observations regarding cholesterol crystals as an activator of the IL-1beta generating inflammasome, and recent Mendelian randomization data for the IL-6 receptor support the hypothesis that inflammatory mediators of atherosclerosis may converge on the central IL-1, tumour necrosis factor (TNF-alpha), IL-6 signalling pathway.	Cholesterol	181-192	interleukin 1 beta	Homo sapiens	419-447
24657674-4	2014	First, in an indirect approach, TGF-beta inhibitor-SB431542 and IL-1beta/TNF-alpha inhibitor SB203580 were locally released from scaffold implants to block their respective signaling pathways.	SB 203580	93-101	interleukin 1 beta	Homo sapiens	64-72
24591481-6	2014	RESULTS: Palmitate, but not oleate, induced caspase activation and cell death in IL-1beta-stimulated normal chondrocytes, and up-regulated the expression of IL-6 and cyclooxygenase 2 in chondrocytes and fibroblast-like synoviocytes through Toll-like receptor 4 (TLR-4) signaling.	Palmitates	9-18	interleukin 1 beta	Homo sapiens	81-89
25061439-3	2014	The Interleukin (IL)-1beta released in the medium of PBMC cultures after treatment with lipopolysaccharides (LPS) alone or LPS and ATP was measured by ELISA.	Adenosine Triphosphate	131-134	interleukin 1 beta	Homo sapiens	4-26
25116711-2	2014	Classically, P2X7 receptor is involved in apoptotic cell death, and it is well known that extracellular ATP ligation to this purinergic receptor serves as an important secondary stimulus, which is also considered as danger signal for the interleukin (IL)-1beta cleavage and secretion from pro-inflammatory cells.	Adenosine Triphosphate	104-107	interleukin 1 beta	Homo sapiens	238-260
25194440-5	2014	Phagocytosis of latex beads by PBMC caused an increased production of TNF-alpha, IL-1beta and IL-10, whereas that of IL-6 declined.	Latex	16-21	interleukin 1 beta	Homo sapiens	81-89
24792436-3	2014	Tylvalosin treatment markedly decreased IL-8, IL-6, IL-1beta, PGE2, TNF-alpha and NO levels in vitro and in vivo.	tylvalosin	0-10	interleukin 1 beta	Homo sapiens	52-60
25610529-7	2014	The chondroprotective effects of kartogenin on IL-1beta-induced release of sulfated glycosaminoglycans from articular cartilage explants, reduction in safranin O staining of neocartilage discs as well as a reduction in aggrecan G1-ITEGE neoepitope in chondrocyte and explant cartilage cultures were observed.	kartogenin	33-43	interleukin 1 beta	Homo sapiens	47-55
25610529-8	2014	Kartogenin partially blocked the IL-1beta-induced increased expression of ADAMTS-5.	kartogenin	0-10	interleukin 1 beta	Homo sapiens	33-41
25268669-7	2014	Finally, in a pilot study of 7 patients with relapsing posterior uveitis refractory to azathioprine and/or cyclosporine, the anti-IL-1beta antibody Gevokizumab was beneficial.	Azathioprine	87-99	interleukin 1 beta	Homo sapiens	130-138
25268669-7	2014	Finally, in a pilot study of 7 patients with relapsing posterior uveitis refractory to azathioprine and/or cyclosporine, the anti-IL-1beta antibody Gevokizumab was beneficial.	Cyclosporine	107-119	interleukin 1 beta	Homo sapiens	130-138
25091484-5	2014	RESULTS: Cholesterol crystals did not induce the nucleotide-binding domain leucine-rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome, but did increase pro-IL-1beta expression in ARPE-19 cells.	Cholesterol	9-20	interleukin 1 beta	Homo sapiens	179-191
25091484-6	2014	Cholesterol crystals increased pro-IL-1beta expression by activating the NF-kappaB pathway.	Cholesterol	0-11	interleukin 1 beta	Homo sapiens	35-43
25610529-11	2014	Similarly, kartogenin enhanced the SMAD1 phosphorylation but only following pretreatment with IL-1beta.	kartogenin	11-21	interleukin 1 beta	Homo sapiens	94-102
25610529-7	2014	The chondroprotective effects of kartogenin on IL-1beta-induced release of sulfated glycosaminoglycans from articular cartilage explants, reduction in safranin O staining of neocartilage discs as well as a reduction in aggrecan G1-ITEGE neoepitope in chondrocyte and explant cartilage cultures were observed.	Glycosaminoglycans	84-102	interleukin 1 beta	Homo sapiens	47-55
24346509-9	2014	RESULTS: Pretreatment with cordycepin significantly inhibited the production of PGE2 and NO induced by IL-1beta.	Dinoprostone	80-84	interleukin 1 beta	Homo sapiens	103-111
24269922-2	2014	The iron regulatory hormone hepcidin is regulated by iron and cytokines interleukin (IL) 6 and IL1beta.	Iron	4-8	interleukin 1 beta	Homo sapiens	95-102
24721152-6	2014	But in the meantime, rhein enhances the activity of caspase-1 by inhibiting intracellular (in situ) IKKbeta, in turn increasing the IL-1beta and high-mobility-group box 1 release, which can be amplified by rhein s reductive effect on intracellular superoxide anion.	Superoxides	248-264	interleukin 1 beta	Homo sapiens	132-140
24677092-4	2014	We provided evidence that the nerve-injury induced suppression of glial glutamate uptake is at least in part ascribed to endogenous IL-1beta and activation of PKC in the spinal dorsal horn.	Glutamic Acid	72-81	interleukin 1 beta	Homo sapiens	132-140
24982221-9	2014	Interleukin-1beta (3 ng/ml) stimulated HGF, but not HPC cells to produce PGE2 in the culture medium.	Dinoprostone	73-77	interleukin 1 beta	Homo sapiens	0-17
24982223-3	2014	Rikkosan alone did not induce prostaglandin E2 (PGE2) production, but inhibited interleukin-1beta (IL-1beta) (5 ng/ml)-stimulated PGE2 production in human gingival fibroblasts and human periodontal ligament fibroblasts, with a selectivity index higher than 4.0 and 4.3, respectively.	Dinoprostone	130-134	interleukin 1 beta	Homo sapiens	80-97
24982223-3	2014	Rikkosan alone did not induce prostaglandin E2 (PGE2) production, but inhibited interleukin-1beta (IL-1beta) (5 ng/ml)-stimulated PGE2 production in human gingival fibroblasts and human periodontal ligament fibroblasts, with a selectivity index higher than 4.0 and 4.3, respectively.	Dinoprostone	130-134	interleukin 1 beta	Homo sapiens	99-107
24982223-8	2014	These results demonstrated that Rikkosan inhibited both IL-1beta production by LPS-activated macrophages and PGE2 production by IL-1beta-stimulated human gingival fibroblasts and human periodontal ligament fibroblasts, suggesting that anti-inflammatory effects of Rikkosan may partially be generated by the inhibition of these pro-inflammatory substances via the IL-1beta network through macrophages to oral tissue cells.	Dinoprostone	109-113	interleukin 1 beta	Homo sapiens	128-136
24982223-8	2014	These results demonstrated that Rikkosan inhibited both IL-1beta production by LPS-activated macrophages and PGE2 production by IL-1beta-stimulated human gingival fibroblasts and human periodontal ligament fibroblasts, suggesting that anti-inflammatory effects of Rikkosan may partially be generated by the inhibition of these pro-inflammatory substances via the IL-1beta network through macrophages to oral tissue cells.	Dinoprostone	109-113	interleukin 1 beta	Homo sapiens	128-136
24346509-11	2014	Pretreatment with cordycepin attenuated IL-1beta-induced activation of NF-kappaB by suppressing degradation of its inhibitory protein nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaB-alpha) in the cytoplasm.	cordycepin	18-28	interleukin 1 beta	Homo sapiens	40-48
24792928-4	2014	Diphenyleneiodonium chloride (NADPH oxidase INH) and N-acetylcysteine (free radical scavenger) attenuated Ox-LDL-induced reactive oxygen species generation, caspase-1 activity, and pro-IL-1beta and mature IL-1beta expression.	diphenyleneiodonium	0-28	interleukin 1 beta	Homo sapiens	185-193
24792928-4	2014	Diphenyleneiodonium chloride (NADPH oxidase INH) and N-acetylcysteine (free radical scavenger) attenuated Ox-LDL-induced reactive oxygen species generation, caspase-1 activity, and pro-IL-1beta and mature IL-1beta expression.	diphenyleneiodonium	0-28	interleukin 1 beta	Homo sapiens	205-213
24857974-2	2014	METHODS: Interleukin-1beta (IL-1beta) stimulated C28/I2 cells underwent mild mechanically treatment while cultured in the presence of the DMOAD diacerein.	diacerein	144-153	interleukin 1 beta	Homo sapiens	9-26
24799081-6	2014	The IC50 value of A. paniculata extract was significantly higher than that of andrographolide on IL-1alpha, IL-1beta, and IL-6 (p &lt; 0.001) release.	andrographolide	78-93	interleukin 1 beta	Homo sapiens	108-116
24799081-7	2014	The IC50 values of andrographolide for IL-1alpha, IL-1beta, and IL-6 were significantly higher (p &lt; 0.001) than that of dexamethasone.	andrographolide	19-34	interleukin 1 beta	Homo sapiens	50-58
24703604-13	2014	Pretreatment with IL-1beta slightly increased membrane type 1-MMP (MT1-MMP) and MMP-2 expression at low to mid-level DHT exposure in vitro, although these trends were not statistically significant.	Dihydrotestosterone	117-120	interleukin 1 beta	Homo sapiens	18-26
24674991-4	2014	We have described the role of aldo-ketoreductase (AKR)1B1 in increased PGF2alpha production by human endometrial cells following stimulation with interleukin-1beta (IL-1beta).	Dinoprost	71-80	interleukin 1 beta	Homo sapiens	146-163
24674991-4	2014	We have described the role of aldo-ketoreductase (AKR)1B1 in increased PGF2alpha production by human endometrial cells following stimulation with interleukin-1beta (IL-1beta).	Dinoprost	71-80	interleukin 1 beta	Homo sapiens	165-173
24674991-12	2014	Knockout cells also maintained their ability to increase PGE2 production in response to IL-1beta.	Dinoprostone	57-61	interleukin 1 beta	Homo sapiens	88-96
24727346-7	2014	Results showed that animals receiving OR486 exhibited higher levels of NO derivatives, tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2) in a beta2- and beta3AR-dependent manner.	OR486	38-43	interleukin 1 beta	Homo sapiens	127-144
24727346-7	2014	Results showed that animals receiving OR486 exhibited higher levels of NO derivatives, tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2) in a beta2- and beta3AR-dependent manner.	OR486	38-43	interleukin 1 beta	Homo sapiens	146-154
24857974-2	2014	METHODS: Interleukin-1beta (IL-1beta) stimulated C28/I2 cells underwent mild mechanically treatment while cultured in the presence of the DMOAD diacerein.	diacerein	144-153	interleukin 1 beta	Homo sapiens	28-36
24978193-6	2014	However, the stable ATP analogue ATPgammaS increased the release of IL-1beta and IFNgamma, and the effect was greatly increased in lungs from smokers.	Adenosine Triphosphate	20-23	interleukin 1 beta	Homo sapiens	68-76
24998372-4	2014	RESULTS: Treatment with formoterol and budesonide 72 h before and after RV14 infection reduced RV14 titers and cytokine concentrations, including interleukin (IL)-1beta, IL-6 and IL-8, in supernatants and viral RNA within cells.	Formoterol Fumarate	24-34	interleukin 1 beta	Homo sapiens	146-168
24998372-4	2014	RESULTS: Treatment with formoterol and budesonide 72 h before and after RV14 infection reduced RV14 titers and cytokine concentrations, including interleukin (IL)-1beta, IL-6 and IL-8, in supernatants and viral RNA within cells.	Budesonide	39-49	interleukin 1 beta	Homo sapiens	146-168
24978193-6	2014	However, the stable ATP analogue ATPgammaS increased the release of IL-1beta and IFNgamma, and the effect was greatly increased in lungs from smokers.	adenosine 5'-O-(3-thiotriphosphate)	33-42	interleukin 1 beta	Homo sapiens	68-76
24796665-4	2014	ALA pretreatment significantly reduced apoptotic cell death of the inner and outer hair cells in cisplatin-treated organ of Corti explants and attenuated ototoxicity via marked inhibition of the increase in the expression of IL-1beta and IL-6, the phosphorylation of ERK and p38, the degradation of IkappaBalpha, the increase in intracellular levels of ROS, and the activation of caspase-3 in cisplatin-treated HEI-OC1 cells.	Thioctic Acid	0-3	interleukin 1 beta	Homo sapiens	225-233
24796665-4	2014	ALA pretreatment significantly reduced apoptotic cell death of the inner and outer hair cells in cisplatin-treated organ of Corti explants and attenuated ototoxicity via marked inhibition of the increase in the expression of IL-1beta and IL-6, the phosphorylation of ERK and p38, the degradation of IkappaBalpha, the increase in intracellular levels of ROS, and the activation of caspase-3 in cisplatin-treated HEI-OC1 cells.	Cisplatin	97-106	interleukin 1 beta	Homo sapiens	225-233
24796665-4	2014	ALA pretreatment significantly reduced apoptotic cell death of the inner and outer hair cells in cisplatin-treated organ of Corti explants and attenuated ototoxicity via marked inhibition of the increase in the expression of IL-1beta and IL-6, the phosphorylation of ERK and p38, the degradation of IkappaBalpha, the increase in intracellular levels of ROS, and the activation of caspase-3 in cisplatin-treated HEI-OC1 cells.	ros	353-356	interleukin 1 beta	Homo sapiens	225-233
24796665-4	2014	ALA pretreatment significantly reduced apoptotic cell death of the inner and outer hair cells in cisplatin-treated organ of Corti explants and attenuated ototoxicity via marked inhibition of the increase in the expression of IL-1beta and IL-6, the phosphorylation of ERK and p38, the degradation of IkappaBalpha, the increase in intracellular levels of ROS, and the activation of caspase-3 in cisplatin-treated HEI-OC1 cells.	Cisplatin	393-402	interleukin 1 beta	Homo sapiens	225-233
24991184-5	2014	IL-4 and melatonin downregulated the expression of VEGF, ICAM-1, MMP2, and MMP9 induced by high glucose and IL-1beta.	Melatonin	9-18	interleukin 1 beta	Homo sapiens	108-116
24831018-0	2014	Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1beta-stimulated human articular chondrocytes.	Hydrogen Sulfide	10-26	interleukin 1 beta	Homo sapiens	76-93
24831018-13	2014	CONCLUSION: NaSH and GYY4137 show anti-inflammatory and anti-catabolic properties when added to IL1beta activated osteoarthritic CHs.	GYY 4137	21-28	interleukin 1 beta	Homo sapiens	96-103
24831018-14	2014	Supplementation with exogenous H2S sources can regulate the expression of relevant genes in OA pathogenesis and progression, counteracting IL1beta pro-inflammatory signals that lead to cartilage destruction in part by reducing NFkappaB activation.	Hydrogen Sulfide	31-34	interleukin 1 beta	Homo sapiens	139-146
24991184-0	2014	Interleukin-4 and melatonin ameliorate high glucose and interleukin-1beta stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells.	Melatonin	18-27	interleukin 1 beta	Homo sapiens	56-73
24991184-1	2014	PURPOSE: We aimed to evaluate the effects of two immune regulatory factors, interleukin-4 (IL-4) and melatonin, on several inflammatory mediators that are involved in inflammation and angiogenesis in diabetic retinopathy (DR), in high glucose or interleukin-1beta (IL-1beta) induced primary human retinal endothelial cells (RECs) and human retinal pigment epithelial (RPE) cells.	Melatonin	101-110	interleukin 1 beta	Homo sapiens	246-263
24991184-6	2014	CONCLUSIONS: Our results demonstrated that IL-4 and melatonin inhibited inflammation and angiogenesis triggered by high glucose and IL-1beta, which suggests that these immune regulatory factors may be of potential therapeutic value in DR.	Melatonin	52-61	interleukin 1 beta	Homo sapiens	132-140
24991184-1	2014	PURPOSE: We aimed to evaluate the effects of two immune regulatory factors, interleukin-4 (IL-4) and melatonin, on several inflammatory mediators that are involved in inflammation and angiogenesis in diabetic retinopathy (DR), in high glucose or interleukin-1beta (IL-1beta) induced primary human retinal endothelial cells (RECs) and human retinal pigment epithelial (RPE) cells.	Melatonin	101-110	interleukin 1 beta	Homo sapiens	265-273
25002964-6	2014	RESULTS: Probiotic supplementation was associated with decreased LTA (lipoteichoic acid) induced CCL4, CXCL8, IL-1beta and IL-6 responses at 12 months and decreased CCL4 and IL-1beta secretion at 24 months.	lipoteichoic acid	70-87	interleukin 1 beta	Homo sapiens	110-118
24901233-5	2014	Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	39-43
24962480-10	2014	Oligonol intake attenuated elevations in IL-1beta (an 11.1-fold change vs. a 13.9-fold change immediately after heating; a 12.0-fold change vs. a 12.6-fold change 1h after heating) and IL-6 (an 8.6-fold change vs. a 9.9-fold change immediately after heating; a 9.1-fold change vs. a 10.5-fold change 1h after heating) immediately and 1 h after heating in comparison to those in the placebo group.	oligonol	0-8	interleukin 1 beta	Homo sapiens	41-49
24928142-7	2014	Morphine increased the gene expression of endogenous opioid, proenkephalin, and decreased the pronociceptive cytokine, interleukin-1beta.	Morphine	0-8	interleukin 1 beta	Homo sapiens	119-136
24901709-0	2014	Disruption of interleukin-1beta autocrine signaling rescues complex I activity and improves ROS levels in immortalized epithelial cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.	ros	92-95	interleukin 1 beta	Homo sapiens	14-31
24901709-8	2014	Externally added IL-1beta (5 ng/ml) reduces the mCx-I activity and increases the mitochondrial (MitoSOX probe) and cellular (DCFH-DA probe) ROS levels of S9 (CFTR-corrected IB3-1 CF cells) or Caco-2/pRSctrl cells (shRNA control cells) to values comparable to those of IB3-1 or Caco-2/pRS26 cells (shRNA specific for CFTR).	ros	140-143	interleukin 1 beta	Homo sapiens	17-25
24901709-10	2014	In addition, in IB3-1 or Caco-2/pRS26 cells, IL-1beta blocking antibody, IKK inhibitor III or SB203580 reduced the mitochondrial ROS levels by ~50% and the cellular ROS levels near to basal values.	ros	129-132	interleukin 1 beta	Homo sapiens	45-53
24901709-10	2014	In addition, in IB3-1 or Caco-2/pRS26 cells, IL-1beta blocking antibody, IKK inhibitor III or SB203580 reduced the mitochondrial ROS levels by ~50% and the cellular ROS levels near to basal values.	ros	165-168	interleukin 1 beta	Homo sapiens	45-53
24901709-12	2014	The results suggest that in these cells IL-1beta, through an autocrine effect, acts as a bridge connecting the CFTR with the mCx-I activity and the ROS levels.	ros	148-151	interleukin 1 beta	Homo sapiens	40-48
23933625-8	2014	Twenty-four patients completed the study; fluvastatin significantly and reversibly reduced the levels of 6/12 (50%) biomarkers (IL1beta, VEGF, TNFalpha, IP10, sCD40L and sTF).	Fluvastatin	42-53	interleukin 1 beta	Homo sapiens	128-135
24966627-6	2014	RESULTS: As measured by RT-PCR and real-time PCR, calcitriol was found to suppress the lipopolysaccharide- and ultraviolet B radiation-mediated induction of expression of TLRs, LL-37 and proinflammatory cytokines such as TNF-alpha and IL-1beta in normal human keratinocytes.	Calcitriol	50-60	interleukin 1 beta	Homo sapiens	235-243
24470357-8	2014	Results from NF-kappaB-targeted PCR array analysis showed that flavopiridol suppressed IL-1beta induction of a broad range of inflammatory mediator genes (59 of 67 tested).	alvocidib	63-75	interleukin 1 beta	Homo sapiens	87-95
24470357-11	2014	Finally, in IL-1beta-treated cartilage explants, flavopiridol reduced the release of the matrix degradation product GAG and cleaved COL2A peptides, but did not affect long-term chondrocyte viability.	alvocidib	49-61	interleukin 1 beta	Homo sapiens	12-20
24290139-7	2014	GAG contents and elasticity of pellets decreased (1.4- and 2.6-fold, respectively, p&lt;0.05) following IL-1beta stimulation.	Glycosaminoglycans	0-3	interleukin 1 beta	Homo sapiens	104-112
24927761-6	2014	Staining of CD11b showed that adjudin markedly inhibited microglial activation in both the cortex and the striatum, accompanied by a reduction in the expression and release of cytokines TNF-alpha, IL-1beta and IL-6.	1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide	30-37	interleukin 1 beta	Homo sapiens	197-205
24901054-5	2014	We found that wogonin significantly decreased the secretion and expression of IL-6 and IL-1beta, reduced cell proliferation and nuclear expression of NF-kappaB in adenomas and surrounding tissues and promoted Nrf2 nuclear translocation in surrounding tissues, although overexpressed Nrf2 in tumor tissues was independent of wogonin administration.	wogonin	14-21	interleukin 1 beta	Homo sapiens	87-95
23907550-7	2014	Based on the results, it was concluded that inflammatory cytokine genes, such as TGFB1 and IL1B, can be predictive variables for stable warfarin doses in Korean patients.	Warfarin	136-144	interleukin 1 beta	Homo sapiens	91-95
24879159-4	2014	In a recent study, our group reported that NADPH-dependent ROS deficiency results in autophagic dysfunction that subsequently contributes to increased IL1B/interleukin 1beta production.	NADP	43-48	interleukin 1 beta	Homo sapiens	151-155
24879159-4	2014	In a recent study, our group reported that NADPH-dependent ROS deficiency results in autophagic dysfunction that subsequently contributes to increased IL1B/interleukin 1beta production.	NADP	43-48	interleukin 1 beta	Homo sapiens	156-173
24879159-4	2014	In a recent study, our group reported that NADPH-dependent ROS deficiency results in autophagic dysfunction that subsequently contributes to increased IL1B/interleukin 1beta production.	Reactive Oxygen Species	59-62	interleukin 1 beta	Homo sapiens	151-155
24879159-4	2014	In a recent study, our group reported that NADPH-dependent ROS deficiency results in autophagic dysfunction that subsequently contributes to increased IL1B/interleukin 1beta production.	Reactive Oxygen Species	59-62	interleukin 1 beta	Homo sapiens	156-173
24901233-5	2014	Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	98-102
24901233-6	2014	We demonstrate that IL-1 signaling and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells.	Curcumin	72-80	interleukin 1 beta	Homo sapiens	20-24
24901233-7	2014	We further show that Curcumin blocks IL-1beta-induced angiogenesis and NF-kappaB-related gene expression.	Curcumin	21-29	interleukin 1 beta	Homo sapiens	37-45
24901233-8	2014	We suppose that IL-1 blockade is an additional treatment option in chondrosarcoma, either by Curcumin, its derivatives or other IL-1 blocking agents.	Curcumin	93-101	interleukin 1 beta	Homo sapiens	16-20
24525029-6	2014	Additionally, exogenous cystine crystals were internalized by monocytes, and inhibition of phagocytosis, cathepsin B leakage, generation of reactive oxygen species, and potassium efflux reduced cystine crystal-induced IL-1beta secretion.	Cystine	24-31	interleukin 1 beta	Homo sapiens	218-226
24632454-6	2014	WFA was found to induce inhibition of phorbol-12-myristate 13-acetate (PMA), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and on cecal ligation and puncture (CLP)-induced EPCR shedding and WFA suppressed the expression and activity of TACE.	withaferin A	0-3	interleukin 1 beta	Homo sapiens	112-134
24849681-8	2014	Based on a logistic regression analysis, smoker phosphate mine workers have a higher relative risk than controls to have an increase concentration of some cytokines, especially IL-1beta, IL-6, IL-8, TNF-alpha, and MIP-1beta.	Phosphates	48-57	interleukin 1 beta	Homo sapiens	177-185
24525029-2	2014	We hypothesized that, similar to other host-derived crystalline moieties, cystine crystals can induce IL-1beta production through inflammasome activation.	Cystine	74-81	interleukin 1 beta	Homo sapiens	102-110
24525029-4	2014	LPS-primed PBMCs stimulated with cystine crystals secreted IL-1beta in a dose-dependent manner.	Cystine	33-40	interleukin 1 beta	Homo sapiens	59-67
24525029-5	2014	Similarly to IL-1beta secretion induced by other crystalline inflammasome activators, cystine crystal-induced IL-1beta secretion required activation of caspase-1.	Cystine	86-93	interleukin 1 beta	Homo sapiens	110-118
24525029-6	2014	Additionally, exogenous cystine crystals were internalized by monocytes, and inhibition of phagocytosis, cathepsin B leakage, generation of reactive oxygen species, and potassium efflux reduced cystine crystal-induced IL-1beta secretion.	Potassium	169-178	interleukin 1 beta	Homo sapiens	218-226
24525029-6	2014	Additionally, exogenous cystine crystals were internalized by monocytes, and inhibition of phagocytosis, cathepsin B leakage, generation of reactive oxygen species, and potassium efflux reduced cystine crystal-induced IL-1beta secretion.	Cystine	194-201	interleukin 1 beta	Homo sapiens	218-226
24673410-8	2014	Moreover, ADT inhibited expression of pro-inflammatory markers induced Nitric Oxide Synthase (iNOS) and IL-1beta while enhanced expression of anti-inflammatory markers arginase 1 and IL-10 in the ischemic brain.	1,4-androstadiene-3,17-dione	10-13	interleukin 1 beta	Homo sapiens	104-112
24849681-9	2014	Moreover, the combined effect of smoking and phosphate dusts exposure increases the level of leucocytes as well as the concentration of IL-1beta, IL-6, IL-8, MIP1-beta, and LTB-4.	Phosphates	45-54	interleukin 1 beta	Homo sapiens	136-144
24665821-6	2014	H2S significantly (P&lt;0.05) upregulated expression of GCLC and GCLM, and formation of GSH, and inhibited IL-1beta secretion in controls and HG-treated monocytes.	Hydrogen Sulfide	0-3	interleukin 1 beta	Homo sapiens	107-115
24665821-0	2014	Hydrogen sulfide upregulates glutamate-cysteine ligase catalytic subunit, glutamate-cysteine ligase modifier subunit, and glutathione and inhibits interleukin-1beta secretion in monocytes exposed to high glucose levels.	Hydrogen Sulfide	0-16	interleukin 1 beta	Homo sapiens	147-164
24665821-7	2014	This is the first demonstration of H2S upregulation of GCLC and GSH and inhibition of IL-1beta levels, which may be what mediates the beneficial effects of H2S-rich compounds in mitigating the pathogenesis of metabolic syndrome and atherosclerosis.	Hydrogen Sulfide	156-159	interleukin 1 beta	Homo sapiens	86-94
24665821-3	2014	This study examined the hypothesis that hydrogen sulfide (H2S) upregulates the glutamate-cysteine ligase catalytic subunit (GCLC) and GSH and inhibits IL-1beta in a monocyte cell model.	Hydrogen Sulfide	40-56	interleukin 1 beta	Homo sapiens	151-159
24665821-3	2014	This study examined the hypothesis that hydrogen sulfide (H2S) upregulates the glutamate-cysteine ligase catalytic subunit (GCLC) and GSH and inhibits IL-1beta in a monocyte cell model.	Hydrogen Sulfide	58-61	interleukin 1 beta	Homo sapiens	151-159
24429678-9	2014	On the other hand, inhibition of class III HDAC SIRT1 using siRNA significantly augmented IL-1beta-induced MMP-9, and SIRT1 activation using resveratrol and SRT1720 inhibited IL-1beta-induced MMP-9 expression.	Resveratrol	141-152	interleukin 1 beta	Homo sapiens	175-183
24792209-9	2014	Gel-200 inhibited IL-1beta-induced production of MMP-1, 3 and 13 in human chondrocytes and production of prostaglandin E2 in human synoviocytes in a concentration-dependent manner, respectively.	Dinoprostone	105-121	interleukin 1 beta	Homo sapiens	18-26
24771848-4	2014	The IL-1beta/IL-1Ra unbalance after activation of multiple TLRs depends on the insurgence of oxidative stress, because of enhanced production of reactive oxygen species and failure of the antioxidant systems.	Reactive Oxygen Species	145-168	interleukin 1 beta	Homo sapiens	4-12
24771848-5	2014	Increased reactive oxygen species levels increase ATP externalization by monocytes, resulting in enhanced inflammasome activation and IL-1beta secretion.	Reactive Oxygen Species	10-33	interleukin 1 beta	Homo sapiens	134-142
24771848-5	2014	Increased reactive oxygen species levels increase ATP externalization by monocytes, resulting in enhanced inflammasome activation and IL-1beta secretion.	Adenosine Triphosphate	50-53	interleukin 1 beta	Homo sapiens	134-142
25177524-7	2014	Biliverdin (50 muM) significantly decreased the LPS-mediated gene expression of IL-1beta, IL-6, IFN-gamma, IL-1Ra and IL-8 (P&lt;0.05).	Biliverdine	0-10	interleukin 1 beta	Homo sapiens	80-88
24587486-0	2014	Enhanced p62 expression through impaired  proteasomal degradation is involved in caspase-1  activation in monosodium urate crystal-induced  interleukin-1b expression.	monosodium urate crystal	106-130	interleukin 1 beta	Homo sapiens	140-154
24587486-1	2014	OBJECTIVE: Evidence for the role of autophagy in the regulation of inflammation, especially IL-1b expression in response to monosodium urate (MSU) crystals, is presented.	Uric Acid	124-140	interleukin 1 beta	Homo sapiens	92-97
24587486-1	2014	OBJECTIVE: Evidence for the role of autophagy in the regulation of inflammation, especially IL-1b expression in response to monosodium urate (MSU) crystals, is presented.	Uric Acid	142-145	interleukin 1 beta	Homo sapiens	92-97
24631939-0	2014	Interleukin-1beta induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood-brain barrier model.	thbmec	120-126	interleukin 1 beta	Homo sapiens	0-17
24848801-11	2014	Consistent with the array data, Western blot analysis showed increased levels of PTGS2 protein induced by IL1beta that was blocked by DEX.	Dexamethasone	134-137	interleukin 1 beta	Homo sapiens	106-113
24886859-0	2014	Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1beta-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes.	Lysine	67-73	interleukin 1 beta	Homo sapiens	91-108
24886859-3	2014	In this study, we investigated the roles of histone H3 lysine 9 (H3K9) methylation in interleukin 1beta (IL-1beta)-induced mPGES-1 expression in human chondrocytes.	Lysine	55-61	interleukin 1 beta	Homo sapiens	86-103
24886859-3	2014	In this study, we investigated the roles of histone H3 lysine 9 (H3K9) methylation in interleukin 1beta (IL-1beta)-induced mPGES-1 expression in human chondrocytes.	Lysine	55-61	interleukin 1 beta	Homo sapiens	105-113
24886859-10	2014	Treatment with tranylcypromine and pargyline, which are potent inhibitors of LSD1, prevented IL-1beta-induced H3K9 demethylation at the mPGES-1 promoter and expression of mPGES-1.	Tranylcypromine	15-30	interleukin 1 beta	Homo sapiens	93-101
24886859-10	2014	Treatment with tranylcypromine and pargyline, which are potent inhibitors of LSD1, prevented IL-1beta-induced H3K9 demethylation at the mPGES-1 promoter and expression of mPGES-1.	Pargyline	35-44	interleukin 1 beta	Homo sapiens	93-101
24870145-3	2014	TLR agonists induced PGE2 in macrophages exclusively via IL-1beta-independent mechanisms.	Dinoprostone	21-25	interleukin 1 beta	Homo sapiens	57-65
24870145-5	2014	Recombinant human IL-1beta augmented COX-2 and mPGES-1 mRNA and PGE2 production in LPS-pretreated monocytes but not in un-primed or Pam3CSK4-primed monocytes.	Dinoprostone	64-68	interleukin 1 beta	Homo sapiens	18-26
24870145-8	2014	Blocking of TLR4 endocytosis during LPS priming prevented the increase in PGE2 production by exogenous IL-1beta.	Dinoprostone	74-78	interleukin 1 beta	Homo sapiens	103-111
24870145-10	2014	In the case of TLR4, IL-1beta augments PGE2 production in LPS-primed monocytes (but not in macrophages) through a mechanism that requires TLR4 internalization and activation of the TRIF/IRF3 pathway.	Dinoprostone	39-43	interleukin 1 beta	Homo sapiens	21-29
24884548-13	2014	Minocycline, chloroquine or simvastatin attenuated upregulation of IL-1beta and iNOS transcripts in different brain regions.	Minocycline	0-11	interleukin 1 beta	Homo sapiens	67-75
24884548-13	2014	Minocycline, chloroquine or simvastatin attenuated upregulation of IL-1beta and iNOS transcripts in different brain regions.	Chloroquine	13-24	interleukin 1 beta	Homo sapiens	67-75
24884548-13	2014	Minocycline, chloroquine or simvastatin attenuated upregulation of IL-1beta and iNOS transcripts in different brain regions.	Simvastatin	28-39	interleukin 1 beta	Homo sapiens	67-75
24884548-14	2014	In CSF, minocycline suppressed TNF-alpha and IL-1beta secretion, whereas chloroquine attenuated IL-1beta secretion.	Minocycline	8-19	interleukin 1 beta	Homo sapiens	45-53
24884548-14	2014	In CSF, minocycline suppressed TNF-alpha and IL-1beta secretion, whereas chloroquine attenuated IL-1beta secretion.	Chloroquine	73-84	interleukin 1 beta	Homo sapiens	96-104
24631018-8	2014	A minimum concentration of ZnO2 nanoparticles of 1 mug/mL inhibited the production of two inflammatory cytokines: interleukin-1-beta and interleukin 6 by peripheral blood mononuclear cells in the presence of lipopolysaccharides.	zno2	27-31	interleukin 1 beta	Homo sapiens	114-132
24876775-4	2014	For in vitro experiments, a pro-oxidant H2O2 or an inflammatory cytokine interleukin (IL)-1beta was employed to induce degenerated phenotypes in human nucleus pulposus cells encapsulated in alginate beads, and fullerol was added in the culture medium.	Alginates	190-198	interleukin 1 beta	Homo sapiens	73-95
24876775-4	2014	For in vitro experiments, a pro-oxidant H2O2 or an inflammatory cytokine interleukin (IL)-1beta was employed to induce degenerated phenotypes in human nucleus pulposus cells encapsulated in alginate beads, and fullerol was added in the culture medium.	fullerol	210-218	interleukin 1 beta	Homo sapiens	73-95
24876775-7	2014	IL-1beta-induced nitric oxide generation in culture medium was suppressed by fullerol as well.	Nitric Oxide	17-29	interleukin 1 beta	Homo sapiens	0-8
24876775-7	2014	IL-1beta-induced nitric oxide generation in culture medium was suppressed by fullerol as well.	fullerol	77-85	interleukin 1 beta	Homo sapiens	0-8
24876775-8	2014	Gene-profile and biochemical assays showed that fullerol effectively reversed the matrix degradation caused by either H2O2 or IL-1beta.	fullerol	48-56	interleukin 1 beta	Homo sapiens	126-134
24613657-4	2014	Only 6-[4-(6-nitroxyacetyl)piperazin-1-yl]-9H-purine (compound MK128) abolished ATP or H2O2-induced IL-1beta production in the culture medium.	6-[4-(6-nitroxyacetyl)piperazin-1-yl]-9h-purine	5-52	interleukin 1 beta	Homo sapiens	100-108
24692548-3	2014	Human pulmonary epithelial A549 cells were used to study the role of the mitogen-activated protein kinase (MAPK) phosphatase, dual-specificity phosphatase 1 (DUSP1), in the dexamethasone repression of 11 inflammatory genes induced, in a MAPK-dependent manner, by interleukin-1beta (IL1B).	Dexamethasone	173-186	interleukin 1 beta	Homo sapiens	263-280
24692548-3	2014	Human pulmonary epithelial A549 cells were used to study the role of the mitogen-activated protein kinase (MAPK) phosphatase, dual-specificity phosphatase 1 (DUSP1), in the dexamethasone repression of 11 inflammatory genes induced, in a MAPK-dependent manner, by interleukin-1beta (IL1B).	Dexamethasone	173-186	interleukin 1 beta	Homo sapiens	282-286
24692548-7	2014	At 1 h, this was responsible for the dexamethasone inhibition of IL1B-induced MAPK activation and CXCL1 and CXCL2 mRNA expression, with a similar trend for CSF2.	Dexamethasone	37-50	interleukin 1 beta	Homo sapiens	65-69
24834055-12	2014	This novel report of STIM1-2 and Orai1-3 mRNA expression in pregnant human myometrium and Orai1 regulation by IL-1beta indicates a potential role for these proteins in calcium signaling in human myometrium during pregnancy.	Calcium	168-175	interleukin 1 beta	Homo sapiens	110-118
24800851-4	2014	Genkwanin potently decreases the proinflammatory mediators, such as iNOS, TNF-alpha, IL-1beta and IL-6, at the transcriptional and translational levels without cytotoxicity, indicating the excellent anti-inflammatory potency of genkwanin in vitro.	genkwanin	0-9	interleukin 1 beta	Homo sapiens	85-93
24613657-4	2014	Only 6-[4-(6-nitroxyacetyl)piperazin-1-yl]-9H-purine (compound MK128) abolished ATP or H2O2-induced IL-1beta production in the culture medium.	mk128	63-68	interleukin 1 beta	Homo sapiens	100-108
24613657-4	2014	Only 6-[4-(6-nitroxyacetyl)piperazin-1-yl]-9H-purine (compound MK128) abolished ATP or H2O2-induced IL-1beta production in the culture medium.	Hydrogen Peroxide	87-91	interleukin 1 beta	Homo sapiens	100-108
24613657-7	2014	The EC50 for inhibition of induced IL-1beta production by the cells was estimated to be 10-12microg/ml (about 36microM) and corresponded to the production of around 30microM nitrites in the culture medium.	Nitrites	174-182	interleukin 1 beta	Homo sapiens	35-43
24613657-12	2014	We suggest that MK128 inhibits IL-1beta production via NO production and subsequent inflammasome component nitrosylation.	mk128	16-21	interleukin 1 beta	Homo sapiens	31-39
24659586-9	2014	In biopsies of patients suffering idiopathic infertility, melatonin testicular concentrations were negatively correlated with MAC number per mm(2) and TNFalpha, IL1beta and COX2 expression, but positively correlated with the expression of the anti-oxidant enzymes SOD1, peroxiredoxin 1 and catalase.	Melatonin	58-67	interleukin 1 beta	Homo sapiens	161-168
24788721-9	2014	Immuno-suppressive effects of ZEA were further revealed through the suppression of lipopolysaccharide (LPS)-induced expression of pro-inflammatory cytokines (IL-6, IL-8 and IL-1beta).	Zearalenone	30-33	interleukin 1 beta	Homo sapiens	173-181
24627579-12	2014	Compared with controls, cells stimulated with interleukin-1 beta (IL-1beta) and treated with ACP showed significantly higher fold changes of MMP-2 (P = .001) and MMP-3 (P = .003) concentrations at 24 hours than did cells treated with GPS.	acp	93-96	interleukin 1 beta	Homo sapiens	46-64
24470226-8	2014	CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways.	Lithium Chloride	12-16	interleukin 1 beta	Homo sapiens	45-53
24627579-12	2014	Compared with controls, cells stimulated with interleukin-1 beta (IL-1beta) and treated with ACP showed significantly higher fold changes of MMP-2 (P = .001) and MMP-3 (P = .003) concentrations at 24 hours than did cells treated with GPS.	acp	93-96	interleukin 1 beta	Homo sapiens	66-74
24470119-1	2014	OBJECTIVE: Monosodium urate monohydrate (MSU) crystal-induced interleukin-1beta (IL-1beta) secretion is a critical factor in the pathogenesis of gout.	Uric Acid	11-39	interleukin 1 beta	Homo sapiens	62-79
24470119-1	2014	OBJECTIVE: Monosodium urate monohydrate (MSU) crystal-induced interleukin-1beta (IL-1beta) secretion is a critical factor in the pathogenesis of gout.	Uric Acid	11-39	interleukin 1 beta	Homo sapiens	81-89
24470119-1	2014	OBJECTIVE: Monosodium urate monohydrate (MSU) crystal-induced interleukin-1beta (IL-1beta) secretion is a critical factor in the pathogenesis of gout.	Uric Acid	41-44	interleukin 1 beta	Homo sapiens	62-79
24470119-1	2014	OBJECTIVE: Monosodium urate monohydrate (MSU) crystal-induced interleukin-1beta (IL-1beta) secretion is a critical factor in the pathogenesis of gout.	Uric Acid	41-44	interleukin 1 beta	Homo sapiens	81-89
24980223-1	2014	BACKGROUND: We recently showed that acute cholesterol depletion in the plasma membrane of NCI-H292 cells by methyl-beta-cyclodextrin suppressed IL-1beta-induced MUC5AC gene expression.	Cholesterol	42-53	interleukin 1 beta	Homo sapiens	144-152
24980223-1	2014	BACKGROUND: We recently showed that acute cholesterol depletion in the plasma membrane of NCI-H292 cells by methyl-beta-cyclodextrin suppressed IL-1beta-induced MUC5AC gene expression.	methyl-beta-cyclodextrin	108-132	interleukin 1 beta	Homo sapiens	144-152
24980223-11	2014	Lovastatin suppressed the activation of p38 MAPK but not ERK1/2 in cells activated with IL-1beta.	Lovastatin	0-10	interleukin 1 beta	Homo sapiens	88-96
24980223-12	2014	This result suggests that lovastatin-mediated suppression of IL-1beta-induced MUC5AC mRNA operated only viathe p38 MAPK-dependent pathway.	Lovastatin	26-36	interleukin 1 beta	Homo sapiens	61-69
25050011-5	2014	However, the mRNA expression of interleukin (IL)-1beta, IL-6, interferon (IFN)-gamma, Toll like receptor (TLR)-4 and HSP70 in the liver of birds fed diet containing vitamin C significantly (p&lt;0.05) decreased compared with those in birds fed basal diet.	Ascorbic Acid	165-174	interleukin 1 beta	Homo sapiens	32-54
24509090-8	2014	We could also show that enhanced microglial TNF-alpha and IL-1beta production in the hippocampus was accompanied by a decrease in the pro-proliferative TNFR2 receptor expression on neuronal progenitor cells, which could be attenuated by minocycline.	Minocycline	237-248	interleukin 1 beta	Homo sapiens	58-66
24480517-9	2014	Moreover, in the pSS group, P2X7R expression on CD14+ PBMC was significantly positively correlated to IL-1beta supernatant levels (r=0.447, p=0.025).	pss	17-20	interleukin 1 beta	Homo sapiens	102-110
24470226-8	2014	CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways.	Lithium Chloride	12-16	interleukin 1 beta	Homo sapiens	147-155
24730521-9	2014	DCs stimulated with rIL-37 showed a decreased expression of IL-6, IL-1beta and TNF-alpha, and a higher production of IL-27.	ril-37	20-26	interleukin 1 beta	Homo sapiens	66-74
24581581-10	2014	In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations.	Estradiol	79-88	interleukin 1 beta	Homo sapiens	31-39
24581581-10	2014	In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations.	Progesterone	93-105	interleukin 1 beta	Homo sapiens	31-39
24487735-7	2014	At the concentrations of 50, 100, and 250 muM, propofol significantly inhibited LPS-mediated production of NO, PGE2, TNF-alpha, and IL-1beta and the expression of iNOSmRNA, COX-2mRNA, TNF-alpha mRNA, and IL-1beta mRNA.	Propofol	47-55	interleukin 1 beta	Homo sapiens	132-140
24487735-7	2014	At the concentrations of 50, 100, and 250 muM, propofol significantly inhibited LPS-mediated production of NO, PGE2, TNF-alpha, and IL-1beta and the expression of iNOSmRNA, COX-2mRNA, TNF-alpha mRNA, and IL-1beta mRNA.	Propofol	47-55	interleukin 1 beta	Homo sapiens	204-212
24556663-10	2014	Bleomycin caused increased macrophages and lymphocytes in the bronchoalveolar lavage (BAL) and elevated interleukin-1beta (IL-1beta), tissue inhibitor of metalloproteinase-1 (TIMP-1), and collagen in lung tissue.	Bleomycin	0-9	interleukin 1 beta	Homo sapiens	104-121
24803317-8	2014	In addition to attenuation of lipopolysaccharide-induced expression of TNF-alpha, IL-1beta, IL-6 in macrophages, and human C-reactive protein in hepatocytes, respectively, at the transcriptional level in vitro, DHI also reduced TNF-alpha protein expression in aortic root of both Apoe-/- and Ldlr-/- mice, suggesting the importance of the anti-inflammatory properties of DHI in the inhibition of lesion development.	dehydrosoyasaponin I	211-214	interleukin 1 beta	Homo sapiens	82-90
25098998-5	2014	RESULTS: IL-1 beta (+3954) TT genotype and T allele were significantly associated with CHPDM group when compared with CHP (P = 0.001), whereas CC genotype and allele C was higher in CHP subjects (P = 0.001).	chpdm	87-92	interleukin 1 beta	Homo sapiens	9-18
24556663-10	2014	Bleomycin caused increased macrophages and lymphocytes in the bronchoalveolar lavage (BAL) and elevated interleukin-1beta (IL-1beta), tissue inhibitor of metalloproteinase-1 (TIMP-1), and collagen in lung tissue.	Bleomycin	0-9	interleukin 1 beta	Homo sapiens	123-131
24803317-8	2014	In addition to attenuation of lipopolysaccharide-induced expression of TNF-alpha, IL-1beta, IL-6 in macrophages, and human C-reactive protein in hepatocytes, respectively, at the transcriptional level in vitro, DHI also reduced TNF-alpha protein expression in aortic root of both Apoe-/- and Ldlr-/- mice, suggesting the importance of the anti-inflammatory properties of DHI in the inhibition of lesion development.	dehydrosoyasaponin I	371-374	interleukin 1 beta	Homo sapiens	82-90
24758933-2	2014	The purpose of this study was to determine whether the protective effect of resveratrol on IL-1beta-induced human articular chondrocytes was associated with the TLR4/MyD88/NF-kB signaling pathway by incubating human articular chondrocytes (harvested from osteoarthritis patients) with IL-1beta before treatment with resveratrol.	Resveratrol	76-87	interleukin 1 beta	Homo sapiens	91-99
25073269-11	2014	The serum level of IL-1beta in the DM group was significantly lower than that in the control group at 3, 24, 48, and 72 hours after operation (P &lt; 0.05), and than that in the mannitol group at all time points after operation (P &lt; 0.05).	Mannitol	178-186	interleukin 1 beta	Homo sapiens	19-27
24758933-0	2014	Protective effect of resveratrol against IL-1beta-induced inflammatory response on human osteoarthritic chondrocytes partly via the TLR4/MyD88/NF-kappaB signaling pathway: an "in vitro study".	Resveratrol	21-32	interleukin 1 beta	Homo sapiens	41-49
24979828-4	2014	To date, case reports and small case series involving colchicine-resistant FMF patients and showing high efficacy of IL-1beta blockade have been reported.	Colchicine	54-64	interleukin 1 beta	Homo sapiens	117-125
24522926-4	2014	We demonstrate here that expression of EVM150, one of the four BTB/kelch proteins, inhibited NF-kappaB activation induced by tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	evm150	39-45	interleukin 1 beta	Homo sapiens	169-186
24522926-4	2014	We demonstrate here that expression of EVM150, one of the four BTB/kelch proteins, inhibited NF-kappaB activation induced by tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	evm150	39-45	interleukin 1 beta	Homo sapiens	188-196
24252030-6	2014	RESULTS: DHMEQ inhibited expression of proIL-1beta and NLRP3 by normal PBMCs primed with LPS, resulting in inhibition of caspase-1 activation and IL-1beta secretion by the cells after subsequent stimulation with ATP.	dehydroxymethylepoxyquinomicin	9-14	interleukin 1 beta	Homo sapiens	39-50
24252030-6	2014	RESULTS: DHMEQ inhibited expression of proIL-1beta and NLRP3 by normal PBMCs primed with LPS, resulting in inhibition of caspase-1 activation and IL-1beta secretion by the cells after subsequent stimulation with ATP.	dehydroxymethylepoxyquinomicin	9-14	interleukin 1 beta	Homo sapiens	42-50
24252030-6	2014	RESULTS: DHMEQ inhibited expression of proIL-1beta and NLRP3 by normal PBMCs primed with LPS, resulting in inhibition of caspase-1 activation and IL-1beta secretion by the cells after subsequent stimulation with ATP.	Adenosine Triphosphate	212-215	interleukin 1 beta	Homo sapiens	39-50
24252030-7	2014	DHMEQ also inhibited expression of IL-1beta, TNFalpha, IL-6 and VCAM-1 by HUVECs.	dehydroxymethylepoxyquinomicin	0-5	interleukin 1 beta	Homo sapiens	35-43
24252030-9	2014	Both the spontaneous and stimulated IL-1beta releases were inhibited by DHMEQ without affecting viability of the cells.	dehydroxymethylepoxyquinomicin	72-77	interleukin 1 beta	Homo sapiens	36-44
24964617-6	2014	RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h.	nickel sulfate	113-118	interleukin 1 beta	Homo sapiens	45-53
24964617-6	2014	RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h.	Dinitrochlorobenzene	120-124	interleukin 1 beta	Homo sapiens	45-53
24964617-6	2014	RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h.	4-(2'-pyridyldithio)benzyldiazoacetate	145-149	interleukin 1 beta	Homo sapiens	45-53
24759736-9	2014	RESULT: H2O2 enhanced IL1beta-induced IL-6 and CXCL8 expression in NHBE and BEAS-2B cells whereas H2O2 alone did not have any affect.	Hydrogen Peroxide	8-12	interleukin 1 beta	Homo sapiens	22-29
24759736-9	2014	RESULT: H2O2 enhanced IL1beta-induced IL-6 and CXCL8 expression in NHBE and BEAS-2B cells whereas H2O2 alone did not have any affect.	Hydrogen Peroxide	98-102	interleukin 1 beta	Homo sapiens	22-29
24758933-2	2014	The purpose of this study was to determine whether the protective effect of resveratrol on IL-1beta-induced human articular chondrocytes was associated with the TLR4/MyD88/NF-kB signaling pathway by incubating human articular chondrocytes (harvested from osteoarthritis patients) with IL-1beta before treatment with resveratrol.	Resveratrol	76-87	interleukin 1 beta	Homo sapiens	285-293
24758933-5	2014	In addition, TLR4 siRNA was used to block TLR4 expression in chondrocytes further demonstrating that resveratrol prevented IL-1beta-mediated inflammation by TLR4 inhibition.	Resveratrol	101-112	interleukin 1 beta	Homo sapiens	123-131
24758933-6	2014	We found that resveratrol prevented IL-1beta-induced reduction in cell viability.	Resveratrol	14-25	interleukin 1 beta	Homo sapiens	36-44
24758933-8	2014	These IL-1beta-induced inflammatory responses were all effectively reversed by resveratrol.	Resveratrol	79-90	interleukin 1 beta	Homo sapiens	6-14
24758933-10	2014	These data suggested that resveratrol prevented IL-1beta-induced inflammation in human articular chondrocytes at least in part by inhibiting the TLR4/MyD88/NF-kB signaling pathway suggesting that resveratrol has the potential to be used as a nutritional supplement to counteract OA symptoms.	Resveratrol	26-37	interleukin 1 beta	Homo sapiens	48-56
24758933-10	2014	These data suggested that resveratrol prevented IL-1beta-induced inflammation in human articular chondrocytes at least in part by inhibiting the TLR4/MyD88/NF-kB signaling pathway suggesting that resveratrol has the potential to be used as a nutritional supplement to counteract OA symptoms.	Resveratrol	196-207	interleukin 1 beta	Homo sapiens	48-56
24487386-0	2014	IL-1beta induction of MUC5AC gene expression is mediated by CREB and NF-kappaB and repressed by dexamethasone.	Dexamethasone	96-109	interleukin 1 beta	Homo sapiens	0-8
24576488-0	2014	Inhibition of inducible nitric oxide synthase and interleukin-1beta expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide.	Tunicamycin	82-93	interleukin 1 beta	Homo sapiens	50-67
24487386-8	2014	Data show that dexamethasone, a glucocorticoid that transcriptionally represses MUC5AC gene expression under constitutive conditions, also represses IL-1beta-mediated upregulation of MUC5AC gene expression.	Dexamethasone	15-28	interleukin 1 beta	Homo sapiens	149-157
24627146-0	2014	Pirfenidone attenuates the IL-1beta-induced hyaluronic acid increase in orbital fibroblasts from patients with thyroid-associated ophthalmopathy.	pirfenidone	0-11	interleukin 1 beta	Homo sapiens	27-35
24733347-4	2014	Moreover, miR-144-3p mimics (agomir) enhanced the expression of inflammatory factors, including IL-1beta, IL-6 and TNF-alpha, in vivo and in vitro, inhibited cholesterol efflux in THP-1 macrophage-derived foam cells, decreased HDL-C circulation and impaired RCT in vivo, resulting in accelerated pathological progression of atherosclerosis in apoE-/- mice.	Cholesterol	158-169	interleukin 1 beta	Homo sapiens	96-104
24627146-0	2014	Pirfenidone attenuates the IL-1beta-induced hyaluronic acid increase in orbital fibroblasts from patients with thyroid-associated ophthalmopathy.	Hyaluronic Acid	44-59	interleukin 1 beta	Homo sapiens	27-35
24627146-1	2014	PURPOSE: This study aimed to investigate the effect of pirfenidone on the IL-1beta-induced hyaluronic acid (HA) increase in orbital fibroblasts from patients with thyroid-associated ophthalmopathy (TAO).	pirfenidone	55-66	interleukin 1 beta	Homo sapiens	74-82
24627146-1	2014	PURPOSE: This study aimed to investigate the effect of pirfenidone on the IL-1beta-induced hyaluronic acid (HA) increase in orbital fibroblasts from patients with thyroid-associated ophthalmopathy (TAO).	Hyaluronic Acid	91-106	interleukin 1 beta	Homo sapiens	74-82
24627146-1	2014	PURPOSE: This study aimed to investigate the effect of pirfenidone on the IL-1beta-induced hyaluronic acid (HA) increase in orbital fibroblasts from patients with thyroid-associated ophthalmopathy (TAO).	Hyaluronic Acid	108-110	interleukin 1 beta	Homo sapiens	74-82
24627146-3	2014	The effect of pirfenidone on IL-1beta-induced hyaluronic acid synthase (HAS) expression was evaluated.	pirfenidone	14-25	interleukin 1 beta	Homo sapiens	29-37
24627146-7	2014	RESULTS: Pirfenidone strongly attenuated the IL-1beta-induced HA release in a dose-dependent manner.	pirfenidone	9-20	interleukin 1 beta	Homo sapiens	45-53
24627146-8	2014	The IL-1beta-induced HAS expression was decreased significantly following cotreatment with pirfenidone at the mRNA and protein levels.	pirfenidone	91-102	interleukin 1 beta	Homo sapiens	4-12
24627146-10	2014	The IL-1beta-induced ERK and p38 phosphorylation, and AP-1 DNA binding were attenuated in the presence of pirfenidone.	pirfenidone	106-117	interleukin 1 beta	Homo sapiens	4-12
24627146-11	2014	Pirfenidone showed greater potency than dexamethasone in inhibiting increases in IL-1beta-induced HA.	pirfenidone	0-11	interleukin 1 beta	Homo sapiens	81-89
24627146-11	2014	Pirfenidone showed greater potency than dexamethasone in inhibiting increases in IL-1beta-induced HA.	Dexamethasone	40-53	interleukin 1 beta	Homo sapiens	81-89
24627146-12	2014	CONCLUSIONS: Pirfenidone attenuates the IL-1beta-induced HA production in orbital fibroblasts from patients with TAO, at least in part, through suppression of the MAPK-mediated HAS expression.	pirfenidone	13-24	interleukin 1 beta	Homo sapiens	40-48
24631907-6	2014	In contrast, inhibition of soluble epoxide hydrolase by AUDA or TPPU inhibited basal, LPS, IL-1beta and PMA induced TNFalpha release, and LPS-induced NFkappaB p65 nuclear translocation.	12-(3-adamantan-1-ylureido)dodecanoic acid	56-60	interleukin 1 beta	Homo sapiens	91-99
24631907-6	2014	In contrast, inhibition of soluble epoxide hydrolase by AUDA or TPPU inhibited basal, LPS, IL-1beta and PMA induced TNFalpha release, and LPS-induced NFkappaB p65 nuclear translocation.	TPPU	64-68	interleukin 1 beta	Homo sapiens	91-99
23856970-5	2014	Ambroxol (100 nM) reduced RV14 titers and cytokine concentrations of interleukin (IL)-1beta, IL-6 and IL-8 in the supernatants and RV14 RNA in the cells after RV14 infection, in addition to reducing susceptibility to RV14 infection.	Ambroxol	0-8	interleukin 1 beta	Homo sapiens	69-91
24521359-7	2014	The pro-inflammatory cytokine IL-1beta facilitates divalent metal transporter 1 (DMT1)-induced beta-cell iron uptake and consequently ROS formation and apoptosis, and we propose that this mechanism provides the relay between inflammation and oxidative beta-cell damage.	Iron	105-109	interleukin 1 beta	Homo sapiens	30-38
24521359-7	2014	The pro-inflammatory cytokine IL-1beta facilitates divalent metal transporter 1 (DMT1)-induced beta-cell iron uptake and consequently ROS formation and apoptosis, and we propose that this mechanism provides the relay between inflammation and oxidative beta-cell damage.	Reactive Oxygen Species	134-137	interleukin 1 beta	Homo sapiens	30-38
24286238-9	2014	In amnion cells, SLIT3 siRNA knockdown decreased IL-1beta-induced COX-2 expression and prostaglandin PGE2 release.	Dinoprostone	87-105	interleukin 1 beta	Homo sapiens	49-57
24378536-6	2014	Visfatin also significantly elevated the secretion of IL-6 as well as IL-1beta in a longer incubation period, which was partially suppressed by nuclear factor-kappaB (NF-kappaB) inhibitor, BAY11-7082, and c-Jun-N-terminal kinase (JNK) inhibitor, SP600125.	pyrazolanthrone	246-254	interleukin 1 beta	Homo sapiens	70-78
24147777-4	2014	In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR), that ACE2 expression is increased under conditions of cell stress, including hypoxic conditions, IL (interleukin)-1beta treatment and treatment with the AMP mimic AICAR (5-amino-4-imidazolecarboxamide riboside).	acadesine	260-299	interleukin 1 beta	Homo sapiens	187-209
24656753-0	2014	Differential deregulation of astrocytic calcium signalling by amyloid-beta, TNFalpha, IL-1beta and LPS.	Calcium	40-47	interleukin 1 beta	Homo sapiens	86-94
24472059-1	2014	Adenosine triphosphate (ATP) has been described as a danger signal activating the NOD-like receptor-family protein 3 (NLRP3)-inflammasome leading to the pro-inflammatory cytokine, interleukin (IL)-1beta, release in the lung.	Adenosine Triphosphate	0-22	interleukin 1 beta	Homo sapiens	180-202
24472059-1	2014	Adenosine triphosphate (ATP) has been described as a danger signal activating the NOD-like receptor-family protein 3 (NLRP3)-inflammasome leading to the pro-inflammatory cytokine, interleukin (IL)-1beta, release in the lung.	Adenosine Triphosphate	24-27	interleukin 1 beta	Homo sapiens	180-202
24472059-4	2014	We showed that adenosine 5"-[gamma-thio]triphosphate tetralithium salt (ATPgammaS) and 2",3"-O-(4-benzoylbenzoyl) adenosine 5"-triphosphate (BzATP), two stable analogs of ATP, are able to potentiate the release of IL-1beta from human monocyte-derived macrophages induced by low concentration of lipopolysaccharide (LPS).	adenosine 5"-[gamma-thio]triphosphate tetralithium salt	15-70	interleukin 1 beta	Homo sapiens	214-222
24472059-4	2014	We showed that adenosine 5"-[gamma-thio]triphosphate tetralithium salt (ATPgammaS) and 2",3"-O-(4-benzoylbenzoyl) adenosine 5"-triphosphate (BzATP), two stable analogs of ATP, are able to potentiate the release of IL-1beta from human monocyte-derived macrophages induced by low concentration of lipopolysaccharide (LPS).	2",3"-o-(4-benzoylbenzoyl) adenosine 5"-triphosphate	87-139	interleukin 1 beta	Homo sapiens	214-222
24472059-4	2014	We showed that adenosine 5"-[gamma-thio]triphosphate tetralithium salt (ATPgammaS) and 2",3"-O-(4-benzoylbenzoyl) adenosine 5"-triphosphate (BzATP), two stable analogs of ATP, are able to potentiate the release of IL-1beta from human monocyte-derived macrophages induced by low concentration of lipopolysaccharide (LPS).	BzATP	141-146	interleukin 1 beta	Homo sapiens	214-222
24472059-7	2014	NLRP3 and IL-1beta mRNA expression were induced from LPS-primed macrophages, but also after 5-h treatment of BzATP as analysed by reverse transcription quantitative polymerase chain reaction.	BzATP	109-114	interleukin 1 beta	Homo sapiens	10-18
24472059-10	2014	The present results showed the involvement of the P2X7 R-NLRP3 inflammasome pathway in the secretion of IL-1beta from ATP-stimulated human macrophages, and suggest that P2X7 R were not involved in IL-1alpha and IL-6 release.	Adenosine Triphosphate	118-121	interleukin 1 beta	Homo sapiens	104-112
24147777-5	2014	The NAD+-dependent deacetylase SIRT1 (silent information regulator T1) was found to be up-regulated after AICAR treatment but, conversely, was down-regulated after IL-1beta treatment.	NAD	4-8	interleukin 1 beta	Homo sapiens	164-172
24409809-6	2014	IL-1beta could induce production of nitric oxide and decrease of proteoglycan, detected by the Griess reagent and the dimethyl methylene blue, respectively.	Nitric Oxide	36-48	interleukin 1 beta	Homo sapiens	0-8
24409809-6	2014	IL-1beta could induce production of nitric oxide and decrease of proteoglycan, detected by the Griess reagent and the dimethyl methylene blue, respectively.	dimethylmethylene blue	118-141	interleukin 1 beta	Homo sapiens	0-8
24409809-7	2014	The deleterious effects of either H2O2 or IL-1beta could be efficiently prevented by glutathione.	Glutathione	85-96	interleukin 1 beta	Homo sapiens	42-50
24469975-0	2014	Boswellic acids reduce Th17 differentiation via blockade of IL-1beta-mediated IRAK1 signaling.	boswellic acid	0-15	interleukin 1 beta	Homo sapiens	60-68
24296847-2	2014	We sought to assess whether these MVPA-induced changes in insulin sensitivity are mediated by changes in interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-alpha, and IL-1beta.	mvpa	34-38	interleukin 1 beta	Homo sapiens	171-179
23792296-6	2014	Incubation of LPS-primed macrophages with potassium chloride also prevented HNP-1-induced export of mature IL-1beta.	Potassium Chloride	42-60	interleukin 1 beta	Homo sapiens	107-115
24487346-11	2014	Apolipoprotein A-I, interleukin 1 beta, alpha 1 antitrypsin, and matrix metalloproteinase 1 proteins revealed a trend of decreasing western immunoblotting band densities after hyaluronic acid injections.	Hyaluronic Acid	176-191	interleukin 1 beta	Homo sapiens	20-38
24487346-12	2014	The decreases in apolipoprotein A-I and interleukin 1 beta protein band densities were significant in the high molecular weight hyaluronic acid injection group.	Hyaluronic Acid	128-143	interleukin 1 beta	Homo sapiens	40-58
24380723-3	2014	Based on the anti-inflammatory characteristics of DMSO, we elucidated the effects of DMSO on activation of inflammasomes, which are cytoplasmic multi-protein complexes that mediate the maturation of interleukin (IL)-1beta by activating caspase-1 (Casp1).	Dimethyl Sulfoxide	50-54	interleukin 1 beta	Homo sapiens	199-221
24380723-3	2014	Based on the anti-inflammatory characteristics of DMSO, we elucidated the effects of DMSO on activation of inflammasomes, which are cytoplasmic multi-protein complexes that mediate the maturation of interleukin (IL)-1beta by activating caspase-1 (Casp1).	Dimethyl Sulfoxide	85-89	interleukin 1 beta	Homo sapiens	199-221
24380723-4	2014	In the present study, we prove that DMSO attenuated IL-1beta maturation, Casp1 activity, and ASC pyroptosome formation via NLRP3 inflammasome activators.	Dimethyl Sulfoxide	36-40	interleukin 1 beta	Homo sapiens	52-60
24508371-7	2014	In addition, PDGF-BB/IL-1beta induces up-regulation of c-Myc in SMCs on fibrillar collagen; this response is mediated by the increased binding of hTERT, which can form complexes with TPP1 and hnRNPK, to the guanine-rich region of the c-Myc promoter and consequently contributes to cell cycle progression in SMCs on fibrillar collagen.	Guanine	207-214	interleukin 1 beta	Homo sapiens	21-29
24192715-8	2014	Moreover, in both circulating and dermal psoriatic Treg, prone to rapid induction of IL-17, sotrastaurin enhanced Foxp3 expression and prevented IL-17A and IFNgamma production even when stimulated in the presence of the helper T 17-enhancing cytokines IL-1beta or IL-23.	sotrastaurin	92-104	interleukin 1 beta	Homo sapiens	252-260
24158569-6	2014	Together, these results identified a novel innate immune signaling pathway (NLRP3-ASC-caspase-1-IL-1beta) activated by Ni(2+) and provided a mechanistic basis for optimizing the therapeutic intervention against Ni(2+)-induced allergy in patients.	Nickel(2+)	211-217	interleukin 1 beta	Homo sapiens	96-104
24158569-0	2014	Nickel induces interleukin-1beta secretion via the NLRP3-ASC-caspase-1 pathway.	Nickel	0-6	interleukin 1 beta	Homo sapiens	15-32
24158569-3	2014	Here we report that Ni(2+) activates the NLRP3-ASC-caspase-1 immune signaling pathway in antigen-presenting cells, leading to the proteolytic processing and secretion of a proinflammatory cytokine, interleukin-1beta (IL-1beta).	Nickel(2+)	20-26	interleukin 1 beta	Homo sapiens	198-215
24158569-3	2014	Here we report that Ni(2+) activates the NLRP3-ASC-caspase-1 immune signaling pathway in antigen-presenting cells, leading to the proteolytic processing and secretion of a proinflammatory cytokine, interleukin-1beta (IL-1beta).	Nickel(2+)	20-26	interleukin 1 beta	Homo sapiens	217-225
24158569-6	2014	Together, these results identified a novel innate immune signaling pathway (NLRP3-ASC-caspase-1-IL-1beta) activated by Ni(2+) and provided a mechanistic basis for optimizing the therapeutic intervention against Ni(2+)-induced allergy in patients.	Nickel(2+)	119-125	interleukin 1 beta	Homo sapiens	96-104
24534771-16	2014	The mechanisms of ellagic acid induced protection were proved to be due to reduction of NO, MDA, IL-1beta, TNF-alpha, COX-2 and NF-kappaB expression and induction of GSH and IL-10 production.	Ellagic Acid	18-30	interleukin 1 beta	Homo sapiens	97-105
24375705-8	2014	Our data showed that IL-1beta markedly stimulated the expressions of iNOS and COX-2 and the productions of NO, PGE2 , and IL-6, which could be significantly reversed by honokiol.	Dinoprostone	111-115	interleukin 1 beta	Homo sapiens	21-29
24352713-6	2014	MYD88 rs6853 (p = 6.7 x 10(-4)) and IL-1beta rs1143627 in conjunction with rs6853 (p = 1.5 x 10(-3)) were associated with spindle amplitude, and IL-10 rs1800896 was associated with delta power (p = 1.3 x 10(-2)) suggesting involvement of cytokine signalling in modulation of EEG patterns during desflurane anaesthesia.	Desflurane	295-305	interleukin 1 beta	Homo sapiens	36-44
24375705-8	2014	Our data showed that IL-1beta markedly stimulated the expressions of iNOS and COX-2 and the productions of NO, PGE2 , and IL-6, which could be significantly reversed by honokiol.	honokiol	169-177	interleukin 1 beta	Homo sapiens	21-29
24375705-9	2014	Honokiol could also suppress the IL-1beta-triggered activation of IKK/IkappaBalpha/NF-kappaB signaling pathway.	honokiol	0-8	interleukin 1 beta	Homo sapiens	33-41
24375705-10	2014	Moreover, honokiol significantly inhibited the IL-1beta-induced MMP-13 production and collagen II reduction.	honokiol	10-18	interleukin 1 beta	Homo sapiens	47-55
24532802-4	2014	We have shown previously that IL-1beta secretion is induced in primary macrophages exposed to the dietary saturated fatty acid palmitate in combination with LPS.	saturated fatty acid palmitate	106-136	interleukin 1 beta	Homo sapiens	30-38
24474147-6	2014	RESULTS: Proinflammatory mediators IL-1beta and IL-6 were doubled in the controls versus the steroid treatment group at 21 hours following induction of acute vocal fold inflammation.	Steroids	93-100	interleukin 1 beta	Homo sapiens	35-43
24532802-9	2014	In contrast, disrupting lysosomal calcium regulation decreased IL-1beta release by reducing pro-IL-1beta levels.	Calcium	34-41	interleukin 1 beta	Homo sapiens	63-71
24532802-9	2014	In contrast, disrupting lysosomal calcium regulation decreased IL-1beta release by reducing pro-IL-1beta levels.	Calcium	34-41	interleukin 1 beta	Homo sapiens	96-104
24532802-10	2014	The calcium pathway involved the calcium-activated phosphatase calcineurin, which stabilized IL-1beta mRNA.	Calcium	4-11	interleukin 1 beta	Homo sapiens	93-101
24671093-3	2014	In this study we investigated the role of pannexin-1 in P2X7-induced dye uptake and ATP-induced IL-1beta secretion from human monocytes.	Adenosine Triphosphate	84-87	interleukin 1 beta	Homo sapiens	96-104
24671093-7	2014	Probenecid also reduced dye uptake and IL-1beta secretion from human CD14+ monocytes whereas carbenoxolone and 10Panx1 showed no inhibitory effect.	Probenecid	0-10	interleukin 1 beta	Homo sapiens	39-47
24676135-7	2014	Moreover, cellular cytokines IL-1beta, IL-6, IL-8 and TNF-alpha secretion as well as NF-kappaB activation in THP-1 cells were attenuated under high iron conditions.	Iron	148-152	interleukin 1 beta	Homo sapiens	29-37
24469454-0	2014	Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes.	Ketoglutaric Acids	92-111	interleukin 1 beta	Homo sapiens	161-178
24500711-3	2014	Although dexamethasone-mediated activation of the glucocorticoid receptor (GR) potently repressed expression of IL1beta, IL8, and several other pro-inflammatory TNF targets, the expression of anti-inflammatory TNF targets such as TNFAIP3 (A20) and NFKBIA was selectively spared or augmented by dexamethasone treatment.	Dexamethasone	9-22	interleukin 1 beta	Homo sapiens	112-119
24711695-3	2014	Pirfenidone is a multifunctional, orally available small molecule with anti-fibrotic, anti-inflammatory, and antioxidative activities, and has been shown to be a modulator of cytokines and growth factors, including TGF-beta1, TNF-alpha, bFGF, IFN-gamma, IL-1beta, and IL-18 in animal models.	pirfenidone	0-11	interleukin 1 beta	Homo sapiens	254-262
24647589-8	2014	In primary amnion and myometrial cells, silibinin also decreased IL-1beta-induced MMP-9 expression.	Silybin	40-49	interleukin 1 beta	Homo sapiens	65-73
24663124-4	2014	PGF2alpha release by preadipocytes, adipocytes and explants under stimulation by TNF-alpha, IL-1beta or both was measured.	Dinoprost	0-9	interleukin 1 beta	Homo sapiens	92-100
24669186-8	2014	RESULTS: Genistein decreased the secretion of IL-1beta, IL-6, and IL-8 from TNF-alpha-stimulated MH7A cells in a dose-dependent manner.	Genistein	9-18	interleukin 1 beta	Homo sapiens	46-54
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	interleukin 1 beta	Homo sapiens	18-26
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	interleukin 1 beta	Homo sapiens	194-202
24491645-0	2014	Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1beta-stimulated SK-N-SH neuronal cells.	Dinoprostone	32-36	interleukin 1 beta	Homo sapiens	100-108
24491645-2	2014	In this study we have investigated the effects of an extract obtained from the seeds of Picralima nitida (PNE) on PGE2 production in IL-1beta-stimulated cells.	pne	106-109	interleukin 1 beta	Homo sapiens	133-141
24491645-2	2014	In this study we have investigated the effects of an extract obtained from the seeds of Picralima nitida (PNE) on PGE2 production in IL-1beta-stimulated cells.	Dinoprostone	114-118	interleukin 1 beta	Homo sapiens	133-141
24491645-3	2014	MATERIALS AND METHODS: Prostaglandin E2 (PGE2) was measured in supernatants of IL-1beta-stimulated SK-N-SH cells using enzyme immunoassay (EIA) for PGE2.	Dinoprostone	23-39	interleukin 1 beta	Homo sapiens	79-87
24491645-3	2014	MATERIALS AND METHODS: Prostaglandin E2 (PGE2) was measured in supernatants of IL-1beta-stimulated SK-N-SH cells using enzyme immunoassay (EIA) for PGE2.	Dinoprostone	41-45	interleukin 1 beta	Homo sapiens	79-87
24491645-12	2014	CONCLUSIONS: Taken together, these results clearly demonstrate that Picralima nitida suppresses PGE2 production by targeting multiple pathways involving NF-kappaB and MAPK signalling in IL-1beta-stimulated SK-N-SH neuronal cells.	Dinoprostone	96-100	interleukin 1 beta	Homo sapiens	186-194
24469454-7	2014	IL-1beta and TNF-alpha significantly suppressed the activity and expression of IDHs, which correlated with the reduced alpha-ketoglutarate levels.	Ketoglutaric Acids	119-138	interleukin 1 beta	Homo sapiens	0-8
24598787-5	2014	At these concentrations chlorogenic acid significantly decreased platelet inflammatory mediators (sP-selectin, sCD40L, CCL5 and IL-1beta) and increased intraplatelet cAMP levels/PKA activation.	Chlorogenic Acid	24-40	interleukin 1 beta	Homo sapiens	128-136
24252315-6	2014	KEY FINDINGS: Cultured macrophages challenged with zirconia or titanium particles expressed increased mRNA for TLRs 2, 3, 4 and 9, and their adaptors MyD88, TRIF and NF-kappaB and cytokines TNF-alpha, IL-1beta and IL-6, which were also increased at protein level.	Titanium	63-71	interleukin 1 beta	Homo sapiens	201-209
24134164-8	2014	Both cell culture systems and animal models have demonstrated that concomitant exposure to alcohol and HIV/HIV proteins results in increased levels of expression of pro-inflammatory cytokines such as interleukin-1 beta and tumor necrosis factor-alpha, along with increased levels of oxidative stress.	Alcohols	91-98	interleukin 1 beta	Homo sapiens	200-250
24431405-5	2014	Using in vitro models with mouse and human malignant mesothelioma cells, curcumin is shown to induce pyroptosis through activation of caspase-1 and increased release of high-mobility group box 1 (HMGB1) without processing of IL-1beta and IL-18.	Curcumin	73-81	interleukin 1 beta	Homo sapiens	225-233
24022478-2	2014	Bacillus Calmitte Guerin (BCG) vaccination, known to induce interleukin-1beta in tuberculosis, was originally aimed at tuberculosis control, but it showed efficacy against leprosy.	bacillus calmitte guerin	0-24	interleukin 1 beta	Homo sapiens	60-77
24022478-2	2014	Bacillus Calmitte Guerin (BCG) vaccination, known to induce interleukin-1beta in tuberculosis, was originally aimed at tuberculosis control, but it showed efficacy against leprosy.	bcg	26-29	interleukin 1 beta	Homo sapiens	60-77
24837313-7	2014	Adenosine modified myeloid cells express also higher levels of mRNA of proinflammatory cytokines and chemoattractants (IL-6, IL-8, IL-1 b).	Adenosine	0-9	interleukin 1 beta	Homo sapiens	131-137
24431405-9	2014	PCR array analysis using the human inflammasome template revealed that curcumin significantly downregulated levels of inflammasome-related gene expression involved in inflammation, e.g., NF-kappaB, toll-like receptors (TLR), and IL-1beta.	Curcumin	71-79	interleukin 1 beta	Homo sapiens	229-237
23625984-10	2014	Dexamethasone downregulated pro-inflammatory mediator (IL-1beta, IL-6, TNFalpha, IFNgamma, MMP-9, TIMP-1, CCL3 and CXCL8) mRNAs but did not modify expression of vascular remodelling factors (platelet derived growth factor, MMP-2 and collagens I and III).	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	55-63
24431405-6	2014	Absence of IL-1beta processing in response to curcumin-mediated caspase-1 activation is attributed to blockade of pro-IL-1beta priming through inhibition of the NF-kappaB pathway.	Curcumin	46-54	interleukin 1 beta	Homo sapiens	11-19
24431405-6	2014	Absence of IL-1beta processing in response to curcumin-mediated caspase-1 activation is attributed to blockade of pro-IL-1beta priming through inhibition of the NF-kappaB pathway.	Curcumin	46-54	interleukin 1 beta	Homo sapiens	114-126
24480614-6	2014	We found that astaxanthin reduced the expression of MMP-1, MMP-3 and MMP-13 as well as the phosphorylation of two mitogen-activated protein kinases (MAPK) (p38 and ERK1/2) in IL-1beta-stimulated chondrocytes.	astaxanthine	14-25	interleukin 1 beta	Homo sapiens	175-183
24270411-4	2014	Hemizygotic deletion of c-FLIP impaired ATP- and monosodium uric acid (MSU)-induced IL-1beta production in macrophages primed through Toll-like receptors (TLRs).	Adenosine Triphosphate	40-43	interleukin 1 beta	Homo sapiens	84-92
24270411-4	2014	Hemizygotic deletion of c-FLIP impaired ATP- and monosodium uric acid (MSU)-induced IL-1beta production in macrophages primed through Toll-like receptors (TLRs).	monosodium uric acid	49-69	interleukin 1 beta	Homo sapiens	84-92
24270411-4	2014	Hemizygotic deletion of c-FLIP impaired ATP- and monosodium uric acid (MSU)-induced IL-1beta production in macrophages primed through Toll-like receptors (TLRs).	msu	71-74	interleukin 1 beta	Homo sapiens	84-92
24632976-8	2014	Interleukin-1beta (IL-1beta) (3 ng/ml) stimulated the secretion of PGE2 into the culture medium by HGF cells.	Dinoprostone	67-71	interleukin 1 beta	Homo sapiens	0-17
24632976-8	2014	Interleukin-1beta (IL-1beta) (3 ng/ml) stimulated the secretion of PGE2 into the culture medium by HGF cells.	Dinoprostone	67-71	interleukin 1 beta	Homo sapiens	19-27
24632976-9	2014	TiO2 NPs also induced PGE2 production, in synergy with IL-1beta.	titanium dioxide	0-4	interleukin 1 beta	Homo sapiens	55-63
24362470-6	2014	The supernatants of dying CRC cells treated with OXA/5-Fu promoted mouse and human DC maturation, with upregulation of HLA-DR, CD80 and CD86 expression and enhancement of IL-1beta, TNF-alpha, MIP-1alpha, MIP-1beta, RANTES and IP-10 production.	Oxaliplatin	49-52	interleukin 1 beta	Homo sapiens	171-179
24548422-7	2014	Elevated levels of TNF-alpha, interleukin (IL)-6, IL-1beta, interferon (IFN)-gamma and IL-17 were observed during DSS exposure phase which restored to the normal level after DSS removal.	Dextran Sulfate	114-117	interleukin 1 beta	Homo sapiens	50-58
24412990-11	2014	Levels of tumor necrosis factor-alpha-alpha and interleukin-1beta increased after adenosine-triphosphate and decreased after KN62 treatment in CD.	Adenosine Triphosphate	82-104	interleukin 1 beta	Homo sapiens	48-65
24758098-2	2014	The aim of this study was to determine the production of proinflammatory cytokines IL-1beta, IL-6 y TNF-alpha in epithelial cell cultures treated with MTX.	Methotrexate	151-154	interleukin 1 beta	Homo sapiens	83-91
25080789-11	2014	In the group of patients who attained remission on CDAI up to 24th week of therapy higher basal level of IL-IRA, IL-2, IL-8, IL-15, Eotaxin, GM-CSF, IFN-gamma, MIP-1alpha and TNF-alpha was registered In patients who attained remission on DAS 28 higher level of IL-1beta.	cdai	51-55	interleukin 1 beta	Homo sapiens	261-269
24315204-9	2014	Inhibition of IL-1beta secretion by an endocytosis inhibitor, cytochalasin B, and a lysosomal enzyme cathepsin B inhibitor, CA-074 Me, suggested the involvement of lysosomal rupture and leakage of cathepsin B into the cytosol in NLRP3 activation by NPCMD.	Cytochalasin B	62-76	interleukin 1 beta	Homo sapiens	14-22
24550911-5	2014	Over the last few years, it has been reported that HZ, similar to uric acid crystals, asbestos, and silica, is able to trigger IL-1beta production via the activation of the NOD-like receptor containing pyrin domain 3 (NLRP3) inflammasome complex.	Uric Acid	66-75	interleukin 1 beta	Homo sapiens	127-135
24013551-5	2014	The up regulation in nitrite release, cell proliferation, and release of IL-6 and IL-1 beta in LPS stimulated human astrocytoma cells were dose-dependently inhibited by co-treatment with guggulipid.	guggulu extract	187-197	interleukin 1 beta	Homo sapiens	82-91
24380732-8	2014	Bortezomib also inhibited the pro-fibrotic (VEGF, HGF, bFGF, TGF-beta) and pro-inflammatory (IL-1beta, TNF-alpha and IFN-gamma) cytokines significantly in comparison to untreated animals with I/R injury.	Bortezomib	0-10	interleukin 1 beta	Homo sapiens	93-101
24455984-4	2014	At noncytotoxic concentrations, (+)-alpha-pinene (1) elicited the most potent inhibition of the IL-1beta-induced inflammatory and catabolic pathways, namely, NF-kappaB and JNK activation and the expression of the inflammatory (iNOS) and catabolic (MMP-1 and -13) genes.	alpha-pinene	32-48	interleukin 1 beta	Homo sapiens	96-104
24486487-5	2014	In lipopolysaccharide (LPS)-inflamed RAW264.7 macrophages, dh404 dramatically suppressed the expression of pro-inflammatory cytokines including inducible nitric oxide synthase (iNOS), monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein-1 beta (MIP-1beta), while minimally regulating the expression of interleulin-6 (IL-6), IL-1beta, and tumor necrosis factor alpha (TNFalpha).	dh404	59-64	interleukin 1 beta	Homo sapiens	347-355
24442429-1	2014	In this article, we report that retreatment of human monocytic THP-1 cells and primary monocytes with pathogenic Neisseria or with purified lipooligosaccharides (LOS) after previous exposure to LOS induced immune tolerance, as evidenced by reduced TNF-alpha and IL-1beta cytokine expression.	lipid-linked oligosaccharides	140-160	interleukin 1 beta	Homo sapiens	262-270
24563688-4	2014	We observed that Ang1 (10(-8) M), but not Ang2, increased mRNA expression of prominent pro-inflammatory cytokine IL-1beta and its natural antagonist IL-1RA, by up to 32.6- and 10.0-fold respectively, compared to PBS-control.	Lead	212-215	interleukin 1 beta	Homo sapiens	113-121
24678280-7	2014	RESULTS: Mean serum IL-1beta (P = 0.042), IL-4 (P = 0.008), and VEGF (P = 0.01) were found to be significantly reduced by curcumin therapy.	Curcumin	122-130	interleukin 1 beta	Homo sapiens	20-28
24678280-9	2014	CONCLUSIONS: The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1beta, IL-4, and VEGF.	Curcumin	62-70	interleukin 1 beta	Homo sapiens	153-161
24384406-4	2014	Among these, several saponins including ginsenoside Rc, Rd, Rf, Rg3 and F4 were found to inhibit MMP-13 expression in IL-1beta-treated SW1353 cells at non-cytotoxic concentrations (1-50 muM).	Saponins	21-29	interleukin 1 beta	Homo sapiens	118-126
24384406-4	2014	Among these, several saponins including ginsenoside Rc, Rd, Rf, Rg3 and F4 were found to inhibit MMP-13 expression in IL-1beta-treated SW1353 cells at non-cytotoxic concentrations (1-50 muM).	Ginsenosides	40-51	interleukin 1 beta	Homo sapiens	118-126
24384406-9	2014	Taken together, these results indicate that several ginsenosides inhibit MMP-13 expression in IL-1beta-treated chondrocytes.	Ginsenosides	52-64	interleukin 1 beta	Homo sapiens	94-102
24356959-4	2014	In studying the effects of isoprenoid shortage on IL-1 beta generation, we identified a new inflammasome activation signal that originates from defects in autophagy.	Terpenes	27-37	interleukin 1 beta	Homo sapiens	50-59
24356959-5	2014	We find that hypersecretion of IL-1beta and IL-18 requires reactive oxygen species and is associated with an oxidized redox status of monocytes but not lymphocytes.	Reactive Oxygen Species	59-82	interleukin 1 beta	Homo sapiens	31-39
24523548-9	2014	Nonetheless, RSD-induced expression of IL-1beta, TNF-alpha, and IL-6 mRNA in brain CD11b(+) cells was attenuated in eIL-1R1kd mice compared with WT.	RSD	13-16	interleukin 1 beta	Homo sapiens	39-47
24516390-10	2014	siRNA-mediated knockdown of Naip2, but not Naip5, inhibited Shigella-induced caspase-1 activation, IL-1beta maturation and Asc pyroptosome formation.	naip2	28-33	interleukin 1 beta	Homo sapiens	99-107
24550911-5	2014	Over the last few years, it has been reported that HZ, similar to uric acid crystals, asbestos, and silica, is able to trigger IL-1beta production via the activation of the NOD-like receptor containing pyrin domain 3 (NLRP3) inflammasome complex.	Silicon Dioxide	100-106	interleukin 1 beta	Homo sapiens	127-135
24238269-7	2014	However, levels of extracellular IL-1beta were greatly increased by subsequent treatment with the potassium-proton ionophore Adenosine triphosphate (ATP) or nigericin; an effect that was dependent on active caspase-1.	Potassium	98-107	interleukin 1 beta	Homo sapiens	33-41
24238269-7	2014	However, levels of extracellular IL-1beta were greatly increased by subsequent treatment with the potassium-proton ionophore Adenosine triphosphate (ATP) or nigericin; an effect that was dependent on active caspase-1.	Adenosine Triphosphate	125-147	interleukin 1 beta	Homo sapiens	33-41
24285499-8	2014	Glyburide completely blocked CP-induced activation of caspase-1 and the production of IL-1beta at 4 h. At 24 h, glyburide reduced two markers of inflammation by 30-50% and reversed much of the inflammatory morphology.	Glyburide	0-9	interleukin 1 beta	Homo sapiens	86-94
24309183-7	2014	Upon exposure to IFN-gamma, TNF-alpha, or IL-1beta, TEERs declined in dexamethasone-treated cells but remained consistently higher than in cells not receiving glucocorticoids.	Dexamethasone	70-83	interleukin 1 beta	Homo sapiens	42-50
24238269-7	2014	However, levels of extracellular IL-1beta were greatly increased by subsequent treatment with the potassium-proton ionophore Adenosine triphosphate (ATP) or nigericin; an effect that was dependent on active caspase-1.	Adenosine Triphosphate	149-152	interleukin 1 beta	Homo sapiens	33-41
24238269-7	2014	However, levels of extracellular IL-1beta were greatly increased by subsequent treatment with the potassium-proton ionophore Adenosine triphosphate (ATP) or nigericin; an effect that was dependent on active caspase-1.	Nigericin	157-166	interleukin 1 beta	Homo sapiens	33-41
24238269-8	2014	Additionally, ATP induced IL-1beta secretion via the purinergic P2X7 receptor, whereas the pannexin-1 channel was required for nigericin induced IL-1beta secretion.	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	26-34
24238269-8	2014	Additionally, ATP induced IL-1beta secretion via the purinergic P2X7 receptor, whereas the pannexin-1 channel was required for nigericin induced IL-1beta secretion.	Nigericin	127-136	interleukin 1 beta	Homo sapiens	145-153
23505242-9	2014	CONCLUSIONS: MEFV-mutated monocytes display enhanced IL-1beta secretion, which correlates with number of high-penetrance mutations and level of endogenous ROS.	Reactive Oxygen Species	155-158	interleukin 1 beta	Homo sapiens	53-61
24360575-6	2014	High expressions of interleukin-1beta and leukotriene B4 receptor 1 in the intra-neural scarring caused by using silicone conduits revealed that the inflammatory mechanism can be inhibited when the conduit is coated with chitosan.	Silicones	113-121	interleukin 1 beta	Homo sapiens	20-37
24513871-9	2014	Interestingly, amitriptyline treatment reduced NLRP3 and caspase-1 gene expression, and IL-1beta and IL-18 serum levels.	Amitriptyline	15-28	interleukin 1 beta	Homo sapiens	88-96
23931157-4	2014	The co-incubation of the cells with Ind, at a nutritionally relevant concentration (5-25 muM), and IL-1beta prevented the release of the pro-inflammatory cytokines IL-6 and IL-8, PGE2 and NO, the formation of ROS and the loss of thiols in a dose-dependent manner.	Reactive Oxygen Species	209-212	interleukin 1 beta	Homo sapiens	99-107
23931157-0	2014	Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-kappaB-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1beta-exposed Caco-2 cells.	indicaxanthin	0-13	interleukin 1 beta	Homo sapiens	170-178
23931157-2	2014	In the present study, the anti-inflammatory activity of indicaxanthin (Ind), a pigment from the edible fruit of cactus pear (Opuntia ficus-indica, L.), was shown in an IBD model consisting of a human intestinal epithelial cell line (Caco-2 cells) stimulated by IL-1beta, a cytokine known to play a major role in the initiation and amplification of inflammatory activity in IBD.	indicaxanthin	56-69	interleukin 1 beta	Homo sapiens	261-269
23931157-2	2014	In the present study, the anti-inflammatory activity of indicaxanthin (Ind), a pigment from the edible fruit of cactus pear (Opuntia ficus-indica, L.), was shown in an IBD model consisting of a human intestinal epithelial cell line (Caco-2 cells) stimulated by IL-1beta, a cytokine known to play a major role in the initiation and amplification of inflammatory activity in IBD.	indicaxanthin	71-74	interleukin 1 beta	Homo sapiens	261-269
23931157-3	2014	The exposure of Caco-2 cells to IL-1beta brought about the activation of NADPH oxidase (NOX-1) and the generation of reactive oxygen species (ROS) to activate intracellular signalling leading to the activation of NF-kappaB, with the over-expression of inflammatory enzymes and release of pro-inflammatory mediators.	Reactive Oxygen Species	117-140	interleukin 1 beta	Homo sapiens	32-40
23931157-3	2014	The exposure of Caco-2 cells to IL-1beta brought about the activation of NADPH oxidase (NOX-1) and the generation of reactive oxygen species (ROS) to activate intracellular signalling leading to the activation of NF-kappaB, with the over-expression of inflammatory enzymes and release of pro-inflammatory mediators.	Reactive Oxygen Species	142-145	interleukin 1 beta	Homo sapiens	32-40
23931157-4	2014	The co-incubation of the cells with Ind, at a nutritionally relevant concentration (5-25 muM), and IL-1beta prevented the release of the pro-inflammatory cytokines IL-6 and IL-8, PGE2 and NO, the formation of ROS and the loss of thiols in a dose-dependent manner.	Dinoprostone	179-183	interleukin 1 beta	Homo sapiens	99-107
23931157-4	2014	The co-incubation of the cells with Ind, at a nutritionally relevant concentration (5-25 muM), and IL-1beta prevented the release of the pro-inflammatory cytokines IL-6 and IL-8, PGE2 and NO, the formation of ROS and the loss of thiols in a dose-dependent manner.	Sulfhydryl Compounds	229-235	interleukin 1 beta	Homo sapiens	99-107
23931157-5	2014	The co-incubation of the cells with Ind and IL-1beta also prevented the IL-1beta-induced increase of epithelial permeability.	indicaxanthin	36-39	interleukin 1 beta	Homo sapiens	72-80
24513871-12	2014	CONCLUSIONS: These findings provide new insight into the pathogenesis of MDD and the effects of amitriptyline treatment on NLRP3 inflammasome activation and IL-1beta and IL-18 serum levels.	Amitriptyline	96-109	interleukin 1 beta	Homo sapiens	157-165
24286513-8	2014	Acetyl-L-carnitine-cisplatin also caused reduced levels of IL-6, IL-1beta and TNF-alpha, pro-inflammatory cytokines, induced by cisplatin.	Acetylcarnitine	0-18	interleukin 1 beta	Homo sapiens	65-73
24286513-8	2014	Acetyl-L-carnitine-cisplatin also caused reduced levels of IL-6, IL-1beta and TNF-alpha, pro-inflammatory cytokines, induced by cisplatin.	Cisplatin	19-28	interleukin 1 beta	Homo sapiens	65-73
24286513-8	2014	Acetyl-L-carnitine-cisplatin also caused reduced levels of IL-6, IL-1beta and TNF-alpha, pro-inflammatory cytokines, induced by cisplatin.	Cisplatin	128-137	interleukin 1 beta	Homo sapiens	65-73
24005900-0	2014	Baicalein inhibits interleukin-1beta-induced proliferation of human rheumatoid arthritis fibroblast-like synoviocytes.	baicalein	0-9	interleukin 1 beta	Homo sapiens	19-36
24342887-9	2014	Transcripts encoding interleukin (IL)-1beta and IL-6 were significantly decreased by tofacitinib treatment at post-thermocautery day 3.	tofacitinib	85-96	interleukin 1 beta	Homo sapiens	21-43
24060108-4	2014	Treatment with pro-inflammatory cytokines mainly tumor necrosis factor-alpha, interleukin 1-beta, and interferon-gamma induces an increase in inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production.	Nitric Oxide	152-164	interleukin 1 beta	Homo sapiens	78-96
24135410-5	2014	BS patients with vascular involvement showed significantly increased levels of TNF-alpha release at 2-, 4- and 8-h post-treatment and significantly increased IL-1beta levels were detected at 2h (P = 0.005) and 4h (P = 0.025) (n = 10).	Deuterium	191-193	interleukin 1 beta	Homo sapiens	158-166
24248185-11	2014	IL-1beta, IL-6, and TNF-alpha stimulated the expression of UAPs and output of PGs in USMCs.	Prostaglandins	78-81	interleukin 1 beta	Homo sapiens	0-8
24140166-8	2014	RESULTS: Melatonin significantly reduced proinflammatory markers IL-1beta (P &lt; .01) and YKL-40 (P &lt; .05) but not TNF-alpha and IL-6.	Melatonin	9-18	interleukin 1 beta	Homo sapiens	65-73
23884315-7	2014	The mechanism of P. acnes-induced NLRP3 activation and subsequent IL-1beta secretion was found to involve potassium efflux.	Potassium	106-115	interleukin 1 beta	Homo sapiens	66-74
24269698-3	2014	Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages.	Water	31-36	interleukin 1 beta	Homo sapiens	120-128
24269698-3	2014	Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages.	Trichothecenes	65-78	interleukin 1 beta	Homo sapiens	120-128
24269698-3	2014	Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages.	roridin A	101-110	interleukin 1 beta	Homo sapiens	120-128
24269698-5	2014	Here, we show that the trichothecene-induced IL-1beta secretion is dependent on NLRP3 inflammasome in human primary macrophages.	Trichothecenes	23-36	interleukin 1 beta	Homo sapiens	45-53
24269698-8	2014	In addition, gene silencing of c-Cbl, a negative autophagy-related regulator of c-Src, resulted in enhanced secretion of IL-1beta and IL-18 in response to trichothecene mycotoxin stimulation in human macrophages.	trichothecene mycotoxin	155-178	interleukin 1 beta	Homo sapiens	121-129
23533059-0	2014	Different molecular weight hyaluronic acid effects on human macrophage interleukin 1beta production.	Hyaluronic Acid	27-42	interleukin 1 beta	Homo sapiens	71-88
23533059-4	2014	Under the highest inflammatory states, production of interleukin 1beta (IL-1beta) was suppressed in the presence of high molecular weight hyaluronan (HMW-HA) and in the presence of low molecular weight hyaluronan (LMW-HA) at mg/mL concentrations.	Hyaluronic Acid	138-148	interleukin 1 beta	Homo sapiens	53-70
23533059-4	2014	Under the highest inflammatory states, production of interleukin 1beta (IL-1beta) was suppressed in the presence of high molecular weight hyaluronan (HMW-HA) and in the presence of low molecular weight hyaluronan (LMW-HA) at mg/mL concentrations.	Hyaluronic Acid	138-148	interleukin 1 beta	Homo sapiens	72-80
23533059-4	2014	Under the highest inflammatory states, production of interleukin 1beta (IL-1beta) was suppressed in the presence of high molecular weight hyaluronan (HMW-HA) and in the presence of low molecular weight hyaluronan (LMW-HA) at mg/mL concentrations.	Hyaluronic Acid	202-212	interleukin 1 beta	Homo sapiens	53-70
23533059-4	2014	Under the highest inflammatory states, production of interleukin 1beta (IL-1beta) was suppressed in the presence of high molecular weight hyaluronan (HMW-HA) and in the presence of low molecular weight hyaluronan (LMW-HA) at mg/mL concentrations.	Hyaluronic Acid	202-212	interleukin 1 beta	Homo sapiens	72-80
23533059-4	2014	Under the highest inflammatory states, production of interleukin 1beta (IL-1beta) was suppressed in the presence of high molecular weight hyaluronan (HMW-HA) and in the presence of low molecular weight hyaluronan (LMW-HA) at mg/mL concentrations.	lmw-ha	214-220	interleukin 1 beta	Homo sapiens	53-70
23533059-4	2014	Under the highest inflammatory states, production of interleukin 1beta (IL-1beta) was suppressed in the presence of high molecular weight hyaluronan (HMW-HA) and in the presence of low molecular weight hyaluronan (LMW-HA) at mg/mL concentrations.	lmw-ha	214-220	interleukin 1 beta	Homo sapiens	72-80
24005900-2	2014	Considering its anti-proliferatory effects on various cancer cells, we investigated the effects of baicalein on interleukin-1 beta (IL-1beta)-induced proliferation of human RAFLS.	baicalein	99-108	interleukin 1 beta	Homo sapiens	112-130
24005900-2	2014	Considering its anti-proliferatory effects on various cancer cells, we investigated the effects of baicalein on interleukin-1 beta (IL-1beta)-induced proliferation of human RAFLS.	baicalein	99-108	interleukin 1 beta	Homo sapiens	132-140
24005900-5	2014	Notably, baicalein significantly suppressed IL-1beta-mediated RAFLS proliferation (P &lt; 0.05), along with reduced ERK1/2 and p38 phosphorylation.	baicalein	9-18	interleukin 1 beta	Homo sapiens	44-52
24005900-6	2014	The IL-1beta-induced p65 nuclear translocation and NF-kappaB DNA binding activity was significantly decreased by baicalein.	baicalein	113-122	interleukin 1 beta	Homo sapiens	4-12
24005900-7	2014	Additionally, the inhibitory effects of baicalein on IL-1beta-induced proliferation of RAFLS were dose-dependently reversed by the addition of recombinant macrophage migration inhibitory factory (MIF).	baicalein	40-49	interleukin 1 beta	Homo sapiens	53-61
24005900-8	2014	Our results indicate that baicalein inhibits IL-1beta-induced RAFLS proliferation, which involves suppression of NF-kappaB transcriptional activity and MIF-mediated signaling.	baicalein	26-35	interleukin 1 beta	Homo sapiens	45-53
24036988-5	2014	Furthermore, moderate positive correlations were observed between concentration of uric acid and the TLR4 mRNA level, serum IL1beta production (r = 0.649, 0.616), and strong positive correlation was observed between TLR4 mRNA level and serum IL1beta (r = 0.848) in 52 AGA patients.	Uric Acid	83-92	interleukin 1 beta	Homo sapiens	124-131
24054992-0	2014	IPAF inflammasome is involved in interleukin-1beta production from astrocytes, induced by palmitate; implications for Alzheimer"s Disease.	Palmitates	90-99	interleukin 1 beta	Homo sapiens	33-50
24683393-10	2014	CONCLUSIONS: Measurements of IL-1alpha, IL-1beta and TNF-alpha sera concentrations could be assessed in parallel to the improvement of the clinical condition and can constitute a good indication of the efficiency of the isotretinoin treatment.	Isotretinoin	220-232	interleukin 1 beta	Homo sapiens	40-48
24287143-7	2014	The high levels of cytokines IL-1beta, TNF-alpha, and IL-6 from the diversion colitis explants decreased (P &lt; .05) to near normal values with heparin treatments.	Heparin	145-152	interleukin 1 beta	Homo sapiens	29-37
24630009-1	2014	OBJECTIVE: To investigate the inhibitory effect of resveratrol on interleukin-1beta (IL-1beta) production in mesenchymal stem cells (MSCs) exposed to radiation and the action mechanism of resveratrol.	Resveratrol	51-62	interleukin 1 beta	Homo sapiens	85-93
24630009-5	2014	RESULTS: Compared with the radiation group, the resveratrol groups had significantly decreased extracellular secretion of IL-1beta (t = 83.34, 24.48, and 12.52, P &lt; 0.05 for all) and significantly decreased intracellular expression of IL-1beta protein and mRNA (t = 8.695, 14.77, and 13.9, P &lt; 0.05 for all).	Resveratrol	48-59	interleukin 1 beta	Homo sapiens	122-130
24630009-5	2014	RESULTS: Compared with the radiation group, the resveratrol groups had significantly decreased extracellular secretion of IL-1beta (t = 83.34, 24.48, and 12.52, P &lt; 0.05 for all) and significantly decreased intracellular expression of IL-1beta protein and mRNA (t = 8.695, 14.77, and 13.9, P &lt; 0.05 for all).	Resveratrol	48-59	interleukin 1 beta	Homo sapiens	238-246
24630009-6	2014	Compared with those given 200 micromol/L resveratrol alone before radiation, the MSCs treated by SIRT1 silencing and given 200 micromol/L resveratrol before radiation had significantly increased extracellular secretion of IL-1beta (t = 18.57, P &lt; 0.05) and significantly increased intracellular expression of IL-1beta protein and mRNA (t = 10.24, P &lt; 0.05).	Resveratrol	138-149	interleukin 1 beta	Homo sapiens	222-230
24630009-6	2014	Compared with those given 200 micromol/L resveratrol alone before radiation, the MSCs treated by SIRT1 silencing and given 200 micromol/L resveratrol before radiation had significantly increased extracellular secretion of IL-1beta (t = 18.57, P &lt; 0.05) and significantly increased intracellular expression of IL-1beta protein and mRNA (t = 10.24, P &lt; 0.05).	Resveratrol	138-149	interleukin 1 beta	Homo sapiens	312-320
24630009-7	2014	CONCLUSION: Resveratrol can significantly inhibit the production of IL-1beta in MSCs exposed to radiation, and SIRT1 may play a key regulatory role in the process of inflammation induced by radiation.	Resveratrol	12-23	interleukin 1 beta	Homo sapiens	68-76
24479681-4	2014	METHODS: The effects of IL-1beta-induced p38 and JNK activation in GA cells were determined using in vitro Transwell migration and invasion assays of MKN-45 and AGS cells, or an in vivo metastasis assay in nude mice.	mkn-45	150-156	interleukin 1 beta	Homo sapiens	24-32
24479681-7	2014	RESULTS: IL-1beta-induced activation of p38 increased GA cell migration and invasion in vitro and promoted the metastatic potential of GA cells in vivo; these effects were attenuated by p38 siRNA or the p38 inhibitor SB202190.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	217-225	interleukin 1 beta	Homo sapiens	9-17
24479681-15	2014	CONCLUSIONS: IL-1beta-induced p38 activation and the IL-1beta/p38/AP-1(c-fos)/MMP2 &amp; MMP9 pathway play an important role in metastasis in GA; this pathway may provide a novel therapeutic target for GA.	Adenosine Monophosphate	84-87	interleukin 1 beta	Homo sapiens	13-21
24479681-15	2014	CONCLUSIONS: IL-1beta-induced p38 activation and the IL-1beta/p38/AP-1(c-fos)/MMP2 &amp; MMP9 pathway play an important role in metastasis in GA; this pathway may provide a novel therapeutic target for GA.	Adenosine Monophosphate	84-87	interleukin 1 beta	Homo sapiens	53-61
24161591-2	2014	In this study, we have used human myometrial cells to investigate whether cAMP potentiates the ability of progesterone to repress IL-1beta-driven COX-2 expression.	Cyclic AMP	74-78	interleukin 1 beta	Homo sapiens	130-138
24161591-2	2014	In this study, we have used human myometrial cells to investigate whether cAMP potentiates the ability of progesterone to repress IL-1beta-driven COX-2 expression.	Progesterone	106-118	interleukin 1 beta	Homo sapiens	130-138
24161591-3	2014	We found that forskolin enhanced progesterone-repression of IL-1beta-driven COX-2 expression in association with delayed IL-1beta-induced nuclear phospho-p65 entry and reduced NF-kappaB binding to the COX-2 promoter.	Colforsin	14-23	interleukin 1 beta	Homo sapiens	60-68
24161591-3	2014	We found that forskolin enhanced progesterone-repression of IL-1beta-driven COX-2 expression in association with delayed IL-1beta-induced nuclear phospho-p65 entry and reduced NF-kappaB binding to the COX-2 promoter.	Colforsin	14-23	interleukin 1 beta	Homo sapiens	121-129
24630009-0	2014	[Inhibitory effect of resveratrol on expression of IL-1beta in mesenchymal stem cells exposed to radiation].	Resveratrol	22-33	interleukin 1 beta	Homo sapiens	51-59
24630009-1	2014	OBJECTIVE: To investigate the inhibitory effect of resveratrol on interleukin-1beta (IL-1beta) production in mesenchymal stem cells (MSCs) exposed to radiation and the action mechanism of resveratrol.	Resveratrol	51-62	interleukin 1 beta	Homo sapiens	66-83
24731418-1	2014	OBJECTIVE: To compare the ability of the polysaccharide from various Porphyromonas gingivalis (Pg) type and clinical strains in inducing THP-1 cells to produce cytokines interleukin(IL)-1beta, IL-8, and tumor necrosis factor(TNF)-alpha, in order to analyze the immunogenicity of Pg polysaccharide components and the virulence-associated factors of this periodontal pathogen.	Polysaccharides	41-55	interleukin 1 beta	Homo sapiens	170-191
24731418-8	2014	CONCLUSIONS: Polysaccharide extracted from Pg could induced the THP-1 cells to secrete the cytokines of IL-1beta, IL-8 and TNF-alpha.	Polysaccharides	13-27	interleukin 1 beta	Homo sapiens	104-112
24055273-5	2014	Treatment of adipose tissue with IL-1beta decreased insulin-stimulated phosphorylation of IRS-1, GLUT-4 expression and glucose uptake.	Glucose	119-126	interleukin 1 beta	Homo sapiens	33-41
24036988-5	2014	Furthermore, moderate positive correlations were observed between concentration of uric acid and the TLR4 mRNA level, serum IL1beta production (r = 0.649, 0.616), and strong positive correlation was observed between TLR4 mRNA level and serum IL1beta (r = 0.848) in 52 AGA patients.	Uric Acid	83-92	interleukin 1 beta	Homo sapiens	242-249
24457964-6	2014	In this study, we found that in the human glioblastoma cell lines U87MG and U138MG, IL-1beta inhibits the transactivation activity of HIF-1 by promoting the ubiquitin-independent proteasomal degradation of the oxygen-labile alpha-subunit of HIF-1 and downregulates the expression of the HIF-1 target gene adrenomedullin (AM).	Oxygen	210-216	interleukin 1 beta	Homo sapiens	84-92
24615074-0	2014	Effects of eplerenone on the activation of matrix metalloproteinase-2 stimulated by high glucose and interleukin-1beta in human cardiac fibroblasts.	Eplerenone	11-21	interleukin 1 beta	Homo sapiens	101-118
24615074-8	2014	Increases in HG- or IL-1beta-induced MMP-2 activity and mRNA expression were blocked by eplerenone.	Eplerenone	88-98	interleukin 1 beta	Homo sapiens	20-28
24615074-12	2014	Eplerenone normalized the effect of MMP-2 activity and HG- or IL-1beta-induced expression in HCFs.	Eplerenone	0-10	interleukin 1 beta	Homo sapiens	62-70
23941558-7	2014	Vitamin D, 25(OH)D, and 1,25(OH)2D significantly inhibited IL-1beta-induced microsomal PGE synthase (mPGES)-1 expression; in contrast, all three forms of vitamin D stimulated 15-hydroxy PG dehydrogenase, an enzyme that degrades PGE2.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	59-67
24438745-12	2014	Interestingly, PGE2, which is produced by chondrocytes in response to IL-1beta and visfatin/NAMPT, did not stimulate NGF production.	Dinoprostone	15-19	interleukin 1 beta	Homo sapiens	70-78
23941558-7	2014	Vitamin D, 25(OH)D, and 1,25(OH)2D significantly inhibited IL-1beta-induced microsomal PGE synthase (mPGES)-1 expression; in contrast, all three forms of vitamin D stimulated 15-hydroxy PG dehydrogenase, an enzyme that degrades PGE2.	Vitamin D	154-163	interleukin 1 beta	Homo sapiens	59-67
23941558-7	2014	Vitamin D, 25(OH)D, and 1,25(OH)2D significantly inhibited IL-1beta-induced microsomal PGE synthase (mPGES)-1 expression; in contrast, all three forms of vitamin D stimulated 15-hydroxy PG dehydrogenase, an enzyme that degrades PGE2.	Dinoprostone	228-232	interleukin 1 beta	Homo sapiens	59-67
24164087-7	2014	Budesonide also reduced the concentrations of tumour necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8 in bronchoalveolar lavage fluid, but increased interleukin-10 30 min after re-expansion (p &lt; 0.05 for all measures).	Budesonide	0-10	interleukin 1 beta	Homo sapiens	76-93
24389491-6	2014	For ORM1 and ORM2 DEL constructs, significantly increased activities after dexamethasone (DEX) treatments (alone and combined with interleukin (IL)-1beta) were observed.	Dexamethasone	75-88	interleukin 1 beta	Homo sapiens	131-153
24422572-6	2014	The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease.	Uric Acid	63-79	interleukin 1 beta	Homo sapiens	180-188
24422572-6	2014	The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease.	Uric Acid	63-79	interleukin 1 beta	Homo sapiens	180-184
24422572-6	2014	The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease.	Ceramides	81-89	interleukin 1 beta	Homo sapiens	180-188
24422572-6	2014	The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease.	Ceramides	81-89	interleukin 1 beta	Homo sapiens	180-184
24422572-6	2014	The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease.	Cholesterol	91-102	interleukin 1 beta	Homo sapiens	180-188
24422572-6	2014	The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease.	Cholesterol	91-102	interleukin 1 beta	Homo sapiens	180-184
24422572-6	2014	The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease.	Glucose	108-115	interleukin 1 beta	Homo sapiens	180-188
24422572-6	2014	The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease.	Glucose	108-115	interleukin 1 beta	Homo sapiens	180-184
23861314-6	2014	Interestingly, protoporphyrin-IX, a competitive inhibitor of HO-1 activity, partly attenuated the inhibitory effects of Res and Pic (but not TMS) on TNF-alpha and IL-1beta production, suggesting that suppression of TNF-alpha and IL-1beta production correlates at least in part with HO-1 expression.	protoporphyrin IX	15-32	interleukin 1 beta	Homo sapiens	163-171
23861314-6	2014	Interestingly, protoporphyrin-IX, a competitive inhibitor of HO-1 activity, partly attenuated the inhibitory effects of Res and Pic (but not TMS) on TNF-alpha and IL-1beta production, suggesting that suppression of TNF-alpha and IL-1beta production correlates at least in part with HO-1 expression.	protoporphyrin IX	15-32	interleukin 1 beta	Homo sapiens	229-237
24389491-6	2014	For ORM1 and ORM2 DEL constructs, significantly increased activities after dexamethasone (DEX) treatments (alone and combined with interleukin (IL)-1beta) were observed.	Dexamethasone	90-93	interleukin 1 beta	Homo sapiens	131-153
24995301-3	2014	SB203580 is a selective ATP-competitive inhibitor of the p38 mitogen-activated protein kinase (MAPK), which is involved in the regulation of proinflammatory cytokines IL-1beta, IL-6 and TNFalpha synthesis.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	167-175
25162011-3	2014	We assessed the ability of EA and RA to modulate IL-1beta, IL-6, IL-8, IL-10, MCP-1, and TNF-alpha gene expression in HaCaT cells after UVB irradiation.	Ellagic Acid	27-29	interleukin 1 beta	Homo sapiens	49-57
25243125-6	2014	Our results showed that epinephrine pretreatment (10 ng/mL) significantly promoted immune responses from LPS stimulated macrophages, including phagocytic rate, phagocytic index, TNFalpha/IL-1beta/IL-10 secretion, and CD14 expression (P &lt; 0.05).	Epinephrine	24-35	interleukin 1 beta	Homo sapiens	187-195
24982891-2	2014	Significant increase of LNCaP cell death (apoptotic and necrotic) and increased levels of active caspase 3 were observed in cells treated with inhibitors of ERK 1/2 (UO126) and p38 (SB203580) prior to IL-1 beta treatment in comparison to cells treated with UO126, SB203580, or IL-1 beta alone.	SB 203580	182-190	interleukin 1 beta	Homo sapiens	201-210
24982891-2	2014	Significant increase of LNCaP cell death (apoptotic and necrotic) and increased levels of active caspase 3 were observed in cells treated with inhibitors of ERK 1/2 (UO126) and p38 (SB203580) prior to IL-1 beta treatment in comparison to cells treated with UO126, SB203580, or IL-1 beta alone.	SB 203580	182-190	interleukin 1 beta	Homo sapiens	277-286
24982891-2	2014	Significant increase of LNCaP cell death (apoptotic and necrotic) and increased levels of active caspase 3 were observed in cells treated with inhibitors of ERK 1/2 (UO126) and p38 (SB203580) prior to IL-1 beta treatment in comparison to cells treated with UO126, SB203580, or IL-1 beta alone.	U 0126	166-171	interleukin 1 beta	Homo sapiens	201-210
24982891-2	2014	Significant increase of LNCaP cell death (apoptotic and necrotic) and increased levels of active caspase 3 were observed in cells treated with inhibitors of ERK 1/2 (UO126) and p38 (SB203580) prior to IL-1 beta treatment in comparison to cells treated with UO126, SB203580, or IL-1 beta alone.	U 0126	166-171	interleukin 1 beta	Homo sapiens	277-286
24995301-3	2014	SB203580 is a selective ATP-competitive inhibitor of the p38 mitogen-activated protein kinase (MAPK), which is involved in the regulation of proinflammatory cytokines IL-1beta, IL-6 and TNFalpha synthesis.	Adenosine Triphosphate	24-27	interleukin 1 beta	Homo sapiens	167-175
24995301-4	2014	Intravenous injection of SB203580 successfully inhibited (P &lt; 0.01) synthesis of IL-1beta and reduced (P &lt; 0.01) the production of IL-6 in the hypothalamus.	SB 203580	25-33	interleukin 1 beta	Homo sapiens	84-92
24999366-2	2014	The aim of this study was to explore the effects of modified Simiao decoction (MSD) on IL-1 beta and TNF alpha secretion in monocytic THP-1 cells with monosodium urate (MSU) crystals-induced inflammation.	Uric Acid	151-167	interleukin 1 beta	Homo sapiens	87-96
24877120-6	2014	rSLURP-2 inhibited IL-1 beta-induced secretion of IL-6 and TLR4- and TLR9-dependent induction of CXCL10 and IL-8, respectively, in CCL-241.	Cefaclor	131-134	interleukin 1 beta	Homo sapiens	19-28
25070503-7	2014	Likewise, in primary cultured satellite cells, DPZ, alone or in combination, upregulated the expression of VEGF, interleukin-1beta, and fibroblast growth factor 2 protein.	Donepezil	47-50	interleukin 1 beta	Homo sapiens	113-130
24668704-11	2014	Furthermore, IL-1b significantly increased the synthesis of NO and ROS.	Reactive Oxygen Species	67-70	interleukin 1 beta	Homo sapiens	13-18
24668704-15	2014	Additionally, inhibition of the NADPH oxidase with DPI led to a significant downregulation of IL-1b-induced expression of ICAM and VCAM, as well as inhibition of eNOS by L-NMMA, and intracellular calcium by BAPTA.	3-aminodiphenyleneiodium	51-54	interleukin 1 beta	Homo sapiens	94-99
24668704-15	2014	Additionally, inhibition of the NADPH oxidase with DPI led to a significant downregulation of IL-1b-induced expression of ICAM and VCAM, as well as inhibition of eNOS by L-NMMA, and intracellular calcium by BAPTA.	Calcium	196-203	interleukin 1 beta	Homo sapiens	94-99
24668704-15	2014	Additionally, inhibition of the NADPH oxidase with DPI led to a significant downregulation of IL-1b-induced expression of ICAM and VCAM, as well as inhibition of eNOS by L-NMMA, and intracellular calcium by BAPTA.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	207-212	interleukin 1 beta	Homo sapiens	94-99
25050325-6	2014	TNFalpha and IL-1beta provoked rapid, NOX-mediated generation of ROS in advancing growth cones, which preceded paralysis of motility and collapse of morphology.	nicotine 1-N-oxide	38-41	interleukin 1 beta	Homo sapiens	13-21
25050325-6	2014	TNFalpha and IL-1beta provoked rapid, NOX-mediated generation of ROS in advancing growth cones, which preceded paralysis of motility and collapse of morphology.	Reactive Oxygen Species	65-68	interleukin 1 beta	Homo sapiens	13-21
25059554-0	2014	Nicotine induces the production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human periodontal ligament cells: an in vitro study.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	35-43
25059554-6	2014	RESULTS: Compared with the control group, nicotine could significantly induce production of IL-1beta and IL-8 in human PDL cells and cause the similar effects on the expression of the NF-kappaB p65 subunit and NF-kappaB activity.	Nicotine	42-50	interleukin 1 beta	Homo sapiens	92-100
25059554-7	2014	CONCLUSION: This study demonstrates that nicotine could induce production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human PDL cells, providing data for a better understanding of the relationships among smoking, nicotine, and periodontitis.	Nicotine	41-49	interleukin 1 beta	Homo sapiens	77-85
25059554-7	2014	CONCLUSION: This study demonstrates that nicotine could induce production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human PDL cells, providing data for a better understanding of the relationships among smoking, nicotine, and periodontitis.	Nicotine	232-240	interleukin 1 beta	Homo sapiens	77-85
24105615-5	2014	Moreover, IL-1beta release from LPS-primed monocytes stimulated with BzATP was markedly higher in BD patients than in controls.	BzATP	69-74	interleukin 1 beta	Homo sapiens	10-18
24999366-2	2014	The aim of this study was to explore the effects of modified Simiao decoction (MSD) on IL-1 beta and TNF alpha secretion in monocytic THP-1 cells with monosodium urate (MSU) crystals-induced inflammation.	Uric Acid	169-172	interleukin 1 beta	Homo sapiens	87-96
24121974-10	2014	The OxLDL-induced ROS production that mediates IL-1beta maturation mainly depended on the scavenger receptor of CD36 but not SR-A.	Reactive Oxygen Species	18-21	interleukin 1 beta	Homo sapiens	47-55
24099991-6	2014	However, a large hyaluronan coat was seen in cells grown in 20 mM glucose and 1 mM glucosamine, or treated with IL-1beta, TNF-alpha, or TGF-beta.	Hyaluronic Acid	17-27	interleukin 1 beta	Homo sapiens	112-120
24589970-3	2014	Higher IL-1beta levels were produced when cultures were stimulated with PCV than with DPT or Hib, and the concurrent stimulation including PCV7 enhanced the production of IL-1beta.	dpt	86-89	interleukin 1 beta	Homo sapiens	7-15
24589970-3	2014	Higher IL-1beta levels were produced when cultures were stimulated with PCV than with DPT or Hib, and the concurrent stimulation including PCV7 enhanced the production of IL-1beta.	pcv7	139-143	interleukin 1 beta	Homo sapiens	171-179
24648846-4	2014	Histamine reduced IL-1 beta /TNF- alpha -induced CXCL10 protein, but not mRNA, levels independent of H1 and H2 receptor activation, whereas tryptase and MC 2 h supernatants reduced all cytokine-induced CXCL10.	Histamine	0-9	interleukin 1 beta	Homo sapiens	18-27
24295650-3	2014	Here, the effects of Icariin on the expression of MMP-13 in IL-1beta-induced SW 1353 chondrosarcoma cells were investigated.	icariin	21-28	interleukin 1 beta	Homo sapiens	60-68
24295650-11	2014	In addition, treatment with Icariin was associated with lower levels of phosphorylated p38, phosphorylated JNK, and beta-catenin in both IL-1beta-induced SW1353 chondrosarcoma cells and in the rat OA model.	icariin	28-35	interleukin 1 beta	Homo sapiens	137-145
24218043-0	2014	Role of interleukin-1beta in hypoxia-induced depression of glutamate uptake in retinal Muller cells.	Glutamic Acid	59-68	interleukin 1 beta	Homo sapiens	8-25
24218043-4	2014	The present study was performed to investigate the role of interleukin-1beta(IL-1beta)on the glutamate uptake in retinal Muller cells under hypoxia and to study the possible mechanism.	Glutamic Acid	93-102	interleukin 1 beta	Homo sapiens	59-76
24218043-4	2014	The present study was performed to investigate the role of interleukin-1beta(IL-1beta)on the glutamate uptake in retinal Muller cells under hypoxia and to study the possible mechanism.	Glutamic Acid	93-102	interleukin 1 beta	Homo sapiens	77-85
24218043-7	2014	To confirm the effect of IL-1betaon glutamate uptake activity in Muller cells, addition of IL-1ra was used.	Glutamic Acid	36-45	interleukin 1 beta	Homo sapiens	25-29
24218043-9	2014	IL-1betatreatment induced depression of glutamate uptake, decrease of Kir4.1 and GLAST expressions in retinal Muller cells under normoxia.	Glutamic Acid	40-49	interleukin 1 beta	Homo sapiens	0-4
24218043-11	2014	CONCLUSIONS: These findings indicated that decreases in Kir4.1 and GLAST expressions and depression of glutamate uptake in retinal Muller cells under hypoxia may be induced by the inflammatory cytokine IL-1beta.	Glutamic Acid	103-112	interleukin 1 beta	Homo sapiens	202-210
24555677-7	2014	Exposure of THP-1 cells to both sizes of ZnO stimulated and increased release of proinflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6, as well as chemokine IL-8, and upregulated the expression of monocyte chemoattractant protein-1 and cyclooxygenase-2 genes.	Zinc Oxide	41-44	interleukin 1 beta	Homo sapiens	107-129
25421594-0	2014	Water-extracted Ampelopsis brevipedunculata downregulates IL-1beta,CCL5, and COX-2 expression via inhibition of PKC-mediated JNK/NF-kappaB signaling pathways in human monocytic cells.	Water	0-5	interleukin 1 beta	Homo sapiens	58-66
25421594-4	2014	THP-1 cells activated by PMA in the presence or absence of A.bre demonstrated that a water-extract of A.bre inhibited the expression of pro-inflammatory cytokine IL-1beta and chemokine CCL-5 in a dose-dependent manner.	Water	85-90	interleukin 1 beta	Homo sapiens	162-170
25421594-8	2014	Collectively, our data showed that water-extracted A.bre inhibited the protein kinase C-JNKs/NF-kappaB signaling pathways, resulting in the suppression of IL-1beta, CCL-5, and COX-2 expression.	Water	35-40	interleukin 1 beta	Homo sapiens	155-163
25747033-4	2014	Birefringent polyethylene wear particles were found behind the metal cup in macrophages containing pro-inflammatory tumor necrosis factor-alpha and interleukin-1beta, whereas fibroblast-like cells stained for osteoclastogenic receptor activator of nuclear factor kappa B ligand (RANKL).	Polyethylene	13-25	interleukin 1 beta	Homo sapiens	148-165
25747033-4	2014	Birefringent polyethylene wear particles were found behind the metal cup in macrophages containing pro-inflammatory tumor necrosis factor-alpha and interleukin-1beta, whereas fibroblast-like cells stained for osteoclastogenic receptor activator of nuclear factor kappa B ligand (RANKL).	Metals	63-68	interleukin 1 beta	Homo sapiens	148-165
24117795-5	2014	Here, we demonstrate that 1 mm melatonin dosage reduced in IL-1beta-induced HepG2 cells MMP-9 gelatinase activity and inhibited cell invasion and motility through downregulation of MMP-9 gene expression and upregulation of the MMP-9-specific inhibitor tissue inhibitor of metalloproteinases (TIMP)-1.	Melatonin	31-40	interleukin 1 beta	Homo sapiens	59-67
24117795-7	2014	Also, melatonin significantly suppressed IL-1beta-induced nuclear factor-kappaB (NF-kappaB) translocation and transcriptional activity.	Melatonin	6-15	interleukin 1 beta	Homo sapiens	41-49
25263279-6	2014	Alkaline extract of plant leaf, which contains higher amounts of lignin-carbohydrate complex, showed potent anti-inflammatory action against IL-1beta-stimulated human gingival fibroblasts.	lignin-carbohydrate	65-84	interleukin 1 beta	Homo sapiens	141-149
24719521-6	2014	Bufalin down regulated the expression levels of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) during these treatments.	bufalin	0-7	interleukin 1 beta	Homo sapiens	104-121
25265656-7	2014	Remission based on CDAI was associated with higher baseline levels of IL-1b, -2, GM-CSF and TNF-alpha and good outcome according to EULAR criteria with the rapid fall in IL-10 and -13 levels.	cdai	19-23	interleukin 1 beta	Homo sapiens	70-79
25464609-7	2014	Absence of significant lowering of concentrations of other proinflammatory cytokines (IL-1beta and TNF-alpha) and expression of reactive oxygen species in vitro evidenced for complex indirect effect of therapy with atorvastatin on their production.	Atorvastatin	215-227	interleukin 1 beta	Homo sapiens	86-94
24719521-6	2014	Bufalin down regulated the expression levels of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) during these treatments.	bufalin	0-7	interleukin 1 beta	Homo sapiens	123-131
24864134-4	2014	Furthermore, 2-Cl-IB-MECA significantly decreased TNF-alpha-stimulated IL-8 and IL-1beta mRNA expression and secretion, compared to the TNF-alpha-only treated group.	2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide	13-25	interleukin 1 beta	Homo sapiens	80-88
25530684-5	2014	EXPERIMENTAL APPROACH: Time course and dose-dependent release of interleukin- (IL-) 6 and IL-8 from A549 were measured after pretreatment of A549 with EtP (2.5-10 mM), sodium pyruvate (NaP, 10 mM), or EtOH (85-170 mM), and subsequent lipopolysaccharide or IL-1beta stimulation.	ethyl pyruvate	151-154	interleukin 1 beta	Homo sapiens	256-264
25089076-6	2014	Puerarin also reduced the upregulated levels of nuclear factor-kappaB (NF-kappaB) and other proinflammatory cytokines, such as IL-6, IL-1beta, and TNF-alpha, in the spinal cord.	puerarin	0-8	interleukin 1 beta	Homo sapiens	133-141
25386047-0	2014	Epigallocatechin gallate attenuates proliferation and oxidative stress in human vascular smooth muscle cells induced by interleukin-1beta via heme oxygenase-1.	epigallocatechin gallate	0-24	interleukin 1 beta	Homo sapiens	120-137
24908318-0	2014	Chromatin immunoprecipitation analysis of bortezomib-mediated inhibition of NFkappaB recruitment to IL-1beta and TNFalpha gene promoters in human macrophages.	Bortezomib	42-52	interleukin 1 beta	Homo sapiens	100-108
25386047-6	2014	The HO-1 inducer CoPPIX decreased IL-1beta-induced cell proliferation, whereas the HO-1 enzyme inhibitor ZnPPIX significantly reversed EGCG-caused growth inhibition in IL-1beta-treated HASMCs.	coppix	17-23	interleukin 1 beta	Homo sapiens	34-42
25386047-6	2014	The HO-1 inducer CoPPIX decreased IL-1beta-induced cell proliferation, whereas the HO-1 enzyme inhibitor ZnPPIX significantly reversed EGCG-caused growth inhibition in IL-1beta-treated HASMCs.	zinc protoporphyrin	105-111	interleukin 1 beta	Homo sapiens	168-176
25386047-6	2014	The HO-1 inducer CoPPIX decreased IL-1beta-induced cell proliferation, whereas the HO-1 enzyme inhibitor ZnPPIX significantly reversed EGCG-caused growth inhibition in IL-1beta-treated HASMCs.	epigallocatechin gallate	135-139	interleukin 1 beta	Homo sapiens	168-176
25386047-6	2014	The HO-1 inducer CoPPIX decreased IL-1beta-induced cell proliferation, whereas the HO-1 enzyme inhibitor ZnPPIX significantly reversed EGCG-caused growth inhibition in IL-1beta-treated HASMCs.	hasmcs	185-191	interleukin 1 beta	Homo sapiens	168-176
24908318-4	2014	In this chapter, we describe a protocol that uses chromatin immunoprecipitation (ChIP) to analyze the NFkappaB recruitment to endogenous IL-1 and TNF promoters in BZ-treated human macrophages.	Bortezomib	163-165	interleukin 1 beta	Homo sapiens	137-141
24908318-5	2014	Corresponding to the BZ-suppressed mRNA levels of IL-1 and TNF, we show that BZ inhibits p65 NFkappaB recruitment to IL-1 and TNF promoters.	Bortezomib	21-23	interleukin 1 beta	Homo sapiens	50-54
24908318-5	2014	Corresponding to the BZ-suppressed mRNA levels of IL-1 and TNF, we show that BZ inhibits p65 NFkappaB recruitment to IL-1 and TNF promoters.	Bortezomib	21-23	interleukin 1 beta	Homo sapiens	117-121
24908318-5	2014	Corresponding to the BZ-suppressed mRNA levels of IL-1 and TNF, we show that BZ inhibits p65 NFkappaB recruitment to IL-1 and TNF promoters.	Bortezomib	77-79	interleukin 1 beta	Homo sapiens	50-54
24908318-5	2014	Corresponding to the BZ-suppressed mRNA levels of IL-1 and TNF, we show that BZ inhibits p65 NFkappaB recruitment to IL-1 and TNF promoters.	Bortezomib	77-79	interleukin 1 beta	Homo sapiens	117-121
24253852-6	2014	After stimulation of the cultures with interleukin-1beta, 8 of the 12 TAF cultures presented higher ICAM-1 levels when compared with the level in the corresponding NAF cultures (p=0.001).	Sodium Fluoride	164-167	interleukin 1 beta	Homo sapiens	39-56
24157594-0	2014	Depressing interleukin-1beta contributed to the synergistic effects of tramadol and minocycline on spinal nerve ligation-induced neuropathic pain.	Tramadol	71-79	interleukin 1 beta	Homo sapiens	11-28
24157594-0	2014	Depressing interleukin-1beta contributed to the synergistic effects of tramadol and minocycline on spinal nerve ligation-induced neuropathic pain.	Minocycline	84-95	interleukin 1 beta	Homo sapiens	11-28
24157594-4	2014	Therefore, the present research is to confirm whether spinal IL-1beta-related pathway response contributes to the synergistic effects of tramadol and minocycline on SNL-induced neuropathic pain.	Tramadol	137-145	interleukin 1 beta	Homo sapiens	61-69
24157594-4	2014	Therefore, the present research is to confirm whether spinal IL-1beta-related pathway response contributes to the synergistic effects of tramadol and minocycline on SNL-induced neuropathic pain.	Minocycline	150-161	interleukin 1 beta	Homo sapiens	61-69
24157594-4	2014	Therefore, the present research is to confirm whether spinal IL-1beta-related pathway response contributes to the synergistic effects of tramadol and minocycline on SNL-induced neuropathic pain.	snl	165-168	interleukin 1 beta	Homo sapiens	61-69
24157594-5	2014	Real-time RT-PCR demonstrated IL-1beta up-expression in the ipsilateral spinal dorsal horn 3 days after lesion, which could be significantly decreased by tramadol and minocycline coadministration.	Tramadol	154-162	interleukin 1 beta	Homo sapiens	30-38
24157594-5	2014	Real-time RT-PCR demonstrated IL-1beta up-expression in the ipsilateral spinal dorsal horn 3 days after lesion, which could be significantly decreased by tramadol and minocycline coadministration.	Minocycline	167-178	interleukin 1 beta	Homo sapiens	30-38
24157594-7	2014	Meanwhile, intrathecal administration of p38 inhibitor SB203580 markedly alleviated mechanical allodynia whilst reducing IL-1beta and Fos expression induced by SNL.	SB 203580	55-63	interleukin 1 beta	Homo sapiens	121-129
24157594-9	2014	These results suggest that depressing SNL-induced aberrant activation of the spinal dorsal horn IL-1beta-related pathway contributes to the underlying mechanism of the synergistic effects of tramadol and minocycline coadministration on SNL-induced neuropathic mechanical allodynia.	Tramadol	191-199	interleukin 1 beta	Homo sapiens	96-104
24157594-9	2014	These results suggest that depressing SNL-induced aberrant activation of the spinal dorsal horn IL-1beta-related pathway contributes to the underlying mechanism of the synergistic effects of tramadol and minocycline coadministration on SNL-induced neuropathic mechanical allodynia.	Minocycline	204-215	interleukin 1 beta	Homo sapiens	96-104
24157594-9	2014	These results suggest that depressing SNL-induced aberrant activation of the spinal dorsal horn IL-1beta-related pathway contributes to the underlying mechanism of the synergistic effects of tramadol and minocycline coadministration on SNL-induced neuropathic mechanical allodynia.	snl	38-41	interleukin 1 beta	Homo sapiens	96-104
24211271-8	2014	Additionally, cisplatin showed a marked pro-inflammatory response as evidenced by significant increase in tissue levels of IL-1beta, TNF-alpha, NF-kB, iNOS, ICAM-1 and MCP-1.	Cisplatin	14-23	interleukin 1 beta	Homo sapiens	123-131
24211233-9	2014	RESULTS: Treatment with WIN-55 alone or in combination with IL-1beta, decreased or abolished MMP-3, -13, TIMP-1 and -2 gene expression in human chondrocyte monolayer and alginate bead cultures in both a concentration and time dependent manner.	win-55	24-30	interleukin 1 beta	Homo sapiens	60-68
24211233-9	2014	RESULTS: Treatment with WIN-55 alone or in combination with IL-1beta, decreased or abolished MMP-3, -13, TIMP-1 and -2 gene expression in human chondrocyte monolayer and alginate bead cultures in both a concentration and time dependent manner.	Alginates	170-178	interleukin 1 beta	Homo sapiens	60-68
24211233-10	2014	WIN-55 treatment alone, and in combination with IL-1beta, reduced MMP-3 and -13 protein production by chondrocytes cultured in alginate beads.	Alginates	127-135	interleukin 1 beta	Homo sapiens	48-56
24211233-12	2014	CONCLUSION: Cannabinoid WIN-55 can reduce both basal and IL-1beta stimulated gene and protein expression of MMP-3 and -13.	Cannabinoids	12-23	interleukin 1 beta	Homo sapiens	57-65
24457951-8	2014	Treatment with TY-51469 resulted in significant reductions in the hepatic malondialdehyde concentration, mast cell numbers, and gene expressions of interleukin-1beta and myeloperoxidase.	Thr-Tyr	15-17	interleukin 1 beta	Homo sapiens	148-185
24754180-5	2014	Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver.	aps	96-99	interleukin 1 beta	Homo sapiens	930-938
24754180-5	2014	Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver.	Cytarabine	102-107	interleukin 1 beta	Homo sapiens	930-938
25374900-4	2013	Interestingly, in cells subjected to chronic interleukin-1beta stimulation, the transcription of the androgen receptor gene is restored within a few cell passages and the cells acquire the ability to grow in the presence of the anti-androgen, bicalutamide.	bicalutamide	243-255	interleukin 1 beta	Homo sapiens	45-62
24070631-3	2013	Two known critical spinal mechanisms underlying taxol-induced neuropathic pain are an increased production of pro-inflammatory cytokines including interleukin-1beta (IL-1beta) and suppressed glial glutamate transporter activities.	Paclitaxel	48-53	interleukin 1 beta	Homo sapiens	147-164
24400007-12	2013	Moreover, l-cit also has the ability to establish an anti-inflammatory profile, characterized by increased IL-10 and reduced IL-1beta and IL-12(p70) generation in the human proximal tubular cells.	Citrulline	10-15	interleukin 1 beta	Homo sapiens	125-133
24261790-3	2013	Other than being comprised of micrometer-sized aggregates that include nanoscale particulates, Alum lacks specific physicochemical properties to explain activation of the innate immune system, including the mechanism by which aluminum-based adjuvants engage the NLRP3 inflammasome and IL-1beta production.	Aluminum	226-234	interleukin 1 beta	Homo sapiens	285-293
24070631-3	2013	Two known critical spinal mechanisms underlying taxol-induced neuropathic pain are an increased production of pro-inflammatory cytokines including interleukin-1beta (IL-1beta) and suppressed glial glutamate transporter activities.	Paclitaxel	48-53	interleukin 1 beta	Homo sapiens	166-174
24104193-7	2013	The results showed that alpinetin inhibited TNF-alpha, IL-6 and IL-1beta expression in LPS-stimulated human THP-1 macrophages in a dose-dependent manner.	alpinetin	24-33	interleukin 1 beta	Homo sapiens	64-72
24330827-8	2013	Cultured human microglia displayed expression of inflammasome-associated genes and responded to inflammasome activators by releasing IL-1beta, which was inhibited by the caspase inhibitor, zVAD-fmk.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	189-197	interleukin 1 beta	Homo sapiens	133-141
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	interleukin 1 beta	Homo sapiens	293-315
23938198-3	2013	We found that dendritic cells (DCs) encapsulated in Ca(2+)-crosslinked alginate (calcium alginate) secreted at least fivefold more of the inflammatory cytokine IL-1beta when compared to DCs encapsulated in agarose and collagen gels, as well as DCs plated on tissue-culture polystyrene (TCPS).	Alginates	71-79	interleukin 1 beta	Homo sapiens	160-168
23938198-3	2013	We found that dendritic cells (DCs) encapsulated in Ca(2+)-crosslinked alginate (calcium alginate) secreted at least fivefold more of the inflammatory cytokine IL-1beta when compared to DCs encapsulated in agarose and collagen gels, as well as DCs plated on tissue-culture polystyrene (TCPS).	Alginates	81-97	interleukin 1 beta	Homo sapiens	160-168
23938198-4	2013	Plating cells on TCPS with the alginate polymer could not reproduce these results, whereas culturing DCs on TCPS with increasing concentrations of Ca(2+) increased IL-1beta, MHC class II and CD86 expression in a dose-dependent manner.	tcps	108-112	interleukin 1 beta	Homo sapiens	164-172
24256257-4	2013	The aim of our work is to understand better the relationship between the endocannabinoid and the IL-1beta (interleukin-1beta) associated signalling pathways and NSC biology, in order to develop therapeutical strategies on CNS diseases that may facilitate brain repair.	Endocannabinoids	73-88	interleukin 1 beta	Homo sapiens	97-105
23928362-9	2013	Further, pro-inflammatory treatments tumor necrosis factor alpha+Interleukin-1beta(TNF1alpha+IL-1ss) designed to mimic febrile illness, resulted in increased malonyl-carnitine levels, reduced CPT1 activity and enhanced LD accumulation, a phenomenon reversed by dexamethasone and TNFalpha or IL-1ss inhibitors.	malonyl-carnitine	158-175	interleukin 1 beta	Homo sapiens	65-82
23928362-9	2013	Further, pro-inflammatory treatments tumor necrosis factor alpha+Interleukin-1beta(TNF1alpha+IL-1ss) designed to mimic febrile illness, resulted in increased malonyl-carnitine levels, reduced CPT1 activity and enhanced LD accumulation, a phenomenon reversed by dexamethasone and TNFalpha or IL-1ss inhibitors.	malonyl-carnitine	158-175	interleukin 1 beta	Homo sapiens	93-97
23928362-9	2013	Further, pro-inflammatory treatments tumor necrosis factor alpha+Interleukin-1beta(TNF1alpha+IL-1ss) designed to mimic febrile illness, resulted in increased malonyl-carnitine levels, reduced CPT1 activity and enhanced LD accumulation, a phenomenon reversed by dexamethasone and TNFalpha or IL-1ss inhibitors.	Dexamethasone	261-274	interleukin 1 beta	Homo sapiens	65-82
23928362-9	2013	Further, pro-inflammatory treatments tumor necrosis factor alpha+Interleukin-1beta(TNF1alpha+IL-1ss) designed to mimic febrile illness, resulted in increased malonyl-carnitine levels, reduced CPT1 activity and enhanced LD accumulation, a phenomenon reversed by dexamethasone and TNFalpha or IL-1ss inhibitors.	Dexamethasone	261-274	interleukin 1 beta	Homo sapiens	93-97
24178768-1	2013	To examine the possible role of taurine chloramine (TauCl) in modulating the expression of adipokines in adipose tissue associated with obesity, we evaluated the effect of TauCl in human differentiated adipocytes in response to IL-1beta.	N-chlorotaurine	172-177	interleukin 1 beta	Homo sapiens	228-236
24178768-6	2013	Treatment with TauCl significantly reversed the modulation of adipokine expression by inhibiting STAT-3 signaling in IL-1beta-stimulated adipocytes, independent of MAPK signaling.	N-chlorotaurine	15-20	interleukin 1 beta	Homo sapiens	117-125
24178768-7	2013	TauCl treatment more significantly modulated the expression of adipokines in adipocytes stimulated with IL-1beta than that of non-stimulated adipocytes, suggesting that TauCl plays a significant role in modulating the expression of adipokines under inflammatory conditions.	N-chlorotaurine	0-5	interleukin 1 beta	Homo sapiens	104-112
24178768-7	2013	TauCl treatment more significantly modulated the expression of adipokines in adipocytes stimulated with IL-1beta than that of non-stimulated adipocytes, suggesting that TauCl plays a significant role in modulating the expression of adipokines under inflammatory conditions.	N-chlorotaurine	169-174	interleukin 1 beta	Homo sapiens	104-112
24256257-4	2013	The aim of our work is to understand better the relationship between the endocannabinoid and the IL-1beta (interleukin-1beta) associated signalling pathways and NSC biology, in order to develop therapeutical strategies on CNS diseases that may facilitate brain repair.	Endocannabinoids	73-88	interleukin 1 beta	Homo sapiens	107-124
23784694-6	2013	Furthermore, we show that esomeprazole abrogates the enhanced VEGF-C expression in tumor cells grown in a acidic medium and stimulated by IL-1beta.	Esomeprazole	26-38	interleukin 1 beta	Homo sapiens	138-146
24060590-10	2013	Transfected EtOH-treated cells showed significantly higher levels of proinflammatory cytokine production as measured by IL-1beta expression.	Ethanol	12-16	interleukin 1 beta	Homo sapiens	120-128
24140411-5	2013	At the transcriptional level, cucurbitacin D enhanced LPS-induced IL-1beta mRNA expression through activation of ERK1/2 mitogen-activated protein kinases (MAPKs).	cucurbitacin D	30-44	interleukin 1 beta	Homo sapiens	66-74
23963575-8	2013	The complex ROS-mediated regulation of neutrophil IL-1beta secretion might constitute a physiological mechanism to control IL-1beta-dependent inflammatory processes where neutrophils play a crucial role.	Reactive Oxygen Species	12-15	interleukin 1 beta	Homo sapiens	50-58
23963575-8	2013	The complex ROS-mediated regulation of neutrophil IL-1beta secretion might constitute a physiological mechanism to control IL-1beta-dependent inflammatory processes where neutrophils play a crucial role.	Reactive Oxygen Species	12-15	interleukin 1 beta	Homo sapiens	123-131
24025977-9	2013	IL-1beta and IL-6 showed significant correlations with PHES, but showed no relationship with critical flicker frequency.	phes	55-59	interleukin 1 beta	Homo sapiens	0-8
24266263-6	2013	Pre- and co-treatments with RSV-LNC were able to protect cultures against ROS formation and cell death induced by Abeta, possibly through sustained blocking of TNF-alpha, IL-1beta, and IL-6 release.	Resveratrol	28-31	interleukin 1 beta	Homo sapiens	171-179
24120989-8	2013	Moreover, H2O2-induced release of IL-9, TNF-alpha, MIP-1alpha and MIP-1beta was not counteracted by DPI, whereas no effect was observed in any experimental condition for both IL-6 and IL-1beta.	Hydrogen Peroxide	10-14	interleukin 1 beta	Homo sapiens	184-192
24117794-0	2013	Myricetin suppresses lipoteichoic acid-induced interleukin-1beta and cyclooxygenase-2 expression in human gingival fibroblasts.	myricetin	0-9	interleukin 1 beta	Homo sapiens	47-64
24117794-0	2013	Myricetin suppresses lipoteichoic acid-induced interleukin-1beta and cyclooxygenase-2 expression in human gingival fibroblasts.	lipoteichoic acid	21-38	interleukin 1 beta	Homo sapiens	47-64
24117794-6	2013	the effect of myricetin on HGFs was assessed by measuring cell viability, signaling pathways and IL-1beta expression and synthesis.	myricetin	14-23	interleukin 1 beta	Homo sapiens	97-105
24145706-6	2013	These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1beta, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway.	Sevoflurane	51-62	interleukin 1 beta	Homo sapiens	139-147
24145706-6	2013	These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1beta, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway.	Nitrous Oxide	67-80	interleukin 1 beta	Homo sapiens	139-147
23963575-0	2013	NADPH oxidase derived reactive oxygen species are involved in human neutrophil IL-1beta secretion but not in inflammasome activation.	Reactive Oxygen Species	22-45	interleukin 1 beta	Homo sapiens	79-87
23963575-4	2013	The role of ROS in IL-1beta processing is still controversial and has not been previously studied in neutrophils.	Reactive Oxygen Species	12-15	interleukin 1 beta	Homo sapiens	19-27
23963575-7	2013	Strikingly, ROS exerted opposite effects on the processing and secretion of IL-1beta; whereas ROS negatively controlled caspase-1 activity, as reported in mononuclear phagocytes, ROS were found to be necessary for the exportation of mature IL-1beta out of the cell, a role never previously described.	Reactive Oxygen Species	12-15	interleukin 1 beta	Homo sapiens	76-84
23963575-7	2013	Strikingly, ROS exerted opposite effects on the processing and secretion of IL-1beta; whereas ROS negatively controlled caspase-1 activity, as reported in mononuclear phagocytes, ROS were found to be necessary for the exportation of mature IL-1beta out of the cell, a role never previously described.	Reactive Oxygen Species	12-15	interleukin 1 beta	Homo sapiens	240-248
23963575-7	2013	Strikingly, ROS exerted opposite effects on the processing and secretion of IL-1beta; whereas ROS negatively controlled caspase-1 activity, as reported in mononuclear phagocytes, ROS were found to be necessary for the exportation of mature IL-1beta out of the cell, a role never previously described.	Reactive Oxygen Species	94-97	interleukin 1 beta	Homo sapiens	76-84
23963575-7	2013	Strikingly, ROS exerted opposite effects on the processing and secretion of IL-1beta; whereas ROS negatively controlled caspase-1 activity, as reported in mononuclear phagocytes, ROS were found to be necessary for the exportation of mature IL-1beta out of the cell, a role never previously described.	Reactive Oxygen Species	94-97	interleukin 1 beta	Homo sapiens	76-84
23020093-5	2013	Its involvement in IL-1beta secretion in co-cultures was demonstrated using a specific antagonist, the brilliant blue G.	coomassie Brilliant Blue	103-119	interleukin 1 beta	Homo sapiens	19-27
24107356-8	2013	HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion.	Vorinostat	17-21	interleukin 1 beta	Homo sapiens	240-248
24107356-8	2013	HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion.	Vorinostat	23-33	interleukin 1 beta	Homo sapiens	240-248
24107356-8	2013	HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion.	Panobinostat	40-46	interleukin 1 beta	Homo sapiens	240-248
24107356-8	2013	HDAC inhibitors, SAHA (vorinostat), and LBH589 (panobinostat) significantly (6.1- and 5.4-fold) elevated miR-146a expression by increasing the binding of the transcription factor NF-kappaB to the miR-146a promoter, and negatively regulated IL-1beta-induced IKK/IkappaB/p65 phosphorylation signaling and IL-6 secretion.	Panobinostat	48-60	interleukin 1 beta	Homo sapiens	240-248
24257035-9	2013	Compared to escitalopram, citalopram led to higher levels of IL-1beta, IL-6, IL-17 and IL-22; and mirtazapine to higher levels of IL-1beta, IL-17, IL-22 and TNF-alpha.	Mirtazapine	98-109	interleukin 1 beta	Homo sapiens	130-138
23877788-3	2013	In this study, we have shown that the P2X7 receptor antagonist, BBG, reduced delayed neuronal death in the hippocampal CA1 region after I/R injury; P2X7 receptor expression levels increased before delayed neuronal death after I/R injury; inhibition of the P2X7 receptor reduced I/R-induced microglial microvesicle-like components, IL-1beta expression, P38 phosphorylation, and glial activation in hippocampal CA1 region after I/R injury.	bbg	64-67	interleukin 1 beta	Homo sapiens	331-339
24283773-0	2013	Association of disease severity with IL-1 levels in methotrexate-treated psoriasis patients.	Methotrexate	52-64	interleukin 1 beta	Homo sapiens	37-41
24283773-3	2013	The aim of this study is to evaluate the effect of Methotrexate (MTX) on IL-1 alpha and IL-1 beta levels in both plasma and skin biopsy of patients with psoriasis and to investigate their association with clinical disease activity.	Methotrexate	51-63	interleukin 1 beta	Homo sapiens	88-97
24283773-3	2013	The aim of this study is to evaluate the effect of Methotrexate (MTX) on IL-1 alpha and IL-1 beta levels in both plasma and skin biopsy of patients with psoriasis and to investigate their association with clinical disease activity.	Methotrexate	65-68	interleukin 1 beta	Homo sapiens	88-97
24283773-12	2013	IL-1beta level in plasma and skin biopsy was higher at day 0 sample and reduced significantly (P &lt; 0.001) after MTX treatment.	Methotrexate	115-118	interleukin 1 beta	Homo sapiens	0-8
24283773-14	2013	Whereas IL-1beta levels showed positive correlation before and after treatment with MTX.	Methotrexate	84-87	interleukin 1 beta	Homo sapiens	8-16
24283773-15	2013	Decreasing IL-1beta levels by MTXs in psoriasis may block the Th17 differentiation.	Methotrexate	30-34	interleukin 1 beta	Homo sapiens	11-19
24259559-0	2013	Glutamate excitotoxicity in the cerebellum mediated by IL-1beta.	Glutamic Acid	0-9	interleukin 1 beta	Homo sapiens	55-63
24257035-4	2013	We systematically investigated the effect of three antidepressant drugs, citalopram, escitalopram and mirtazapine, on secretion of cytokines IL-1beta, IL-2, IL-4, IL-6, IL-17, IL-22 and TNF-alpha in a whole blood assay in vitro, using murine anti-human CD3 monoclonal antibody OKT3, and 5C3 monoclonal antibody against CD40, to stimulate T and B cells respectively.	Citalopram	73-83	interleukin 1 beta	Homo sapiens	141-149
24257035-4	2013	We systematically investigated the effect of three antidepressant drugs, citalopram, escitalopram and mirtazapine, on secretion of cytokines IL-1beta, IL-2, IL-4, IL-6, IL-17, IL-22 and TNF-alpha in a whole blood assay in vitro, using murine anti-human CD3 monoclonal antibody OKT3, and 5C3 monoclonal antibody against CD40, to stimulate T and B cells respectively.	Citalopram	85-97	interleukin 1 beta	Homo sapiens	141-149
24257035-4	2013	We systematically investigated the effect of three antidepressant drugs, citalopram, escitalopram and mirtazapine, on secretion of cytokines IL-1beta, IL-2, IL-4, IL-6, IL-17, IL-22 and TNF-alpha in a whole blood assay in vitro, using murine anti-human CD3 monoclonal antibody OKT3, and 5C3 monoclonal antibody against CD40, to stimulate T and B cells respectively.	Mirtazapine	102-113	interleukin 1 beta	Homo sapiens	141-149
24257035-5	2013	Citalopram increased production of IL-1beta, IL-6, TNF-alpha and IL-22.	Citalopram	0-10	interleukin 1 beta	Homo sapiens	35-43
23786870-1	2013	OBJECTIVES: Acute gouty arthritis is an inflammatory disease resulting from the precipitation of long-term hyperuricemia-induced monosodium urate (MSU) crystals in joints, which stimulates the production of interleukin-1beta (IL-1beta) and initiates an inflammatory reaction.	Uric Acid	129-145	interleukin 1 beta	Homo sapiens	207-224
23786870-1	2013	OBJECTIVES: Acute gouty arthritis is an inflammatory disease resulting from the precipitation of long-term hyperuricemia-induced monosodium urate (MSU) crystals in joints, which stimulates the production of interleukin-1beta (IL-1beta) and initiates an inflammatory reaction.	Uric Acid	129-145	interleukin 1 beta	Homo sapiens	226-234
23786870-1	2013	OBJECTIVES: Acute gouty arthritis is an inflammatory disease resulting from the precipitation of long-term hyperuricemia-induced monosodium urate (MSU) crystals in joints, which stimulates the production of interleukin-1beta (IL-1beta) and initiates an inflammatory reaction.	Uric Acid	147-150	interleukin 1 beta	Homo sapiens	207-224
23786870-1	2013	OBJECTIVES: Acute gouty arthritis is an inflammatory disease resulting from the precipitation of long-term hyperuricemia-induced monosodium urate (MSU) crystals in joints, which stimulates the production of interleukin-1beta (IL-1beta) and initiates an inflammatory reaction.	Uric Acid	147-150	interleukin 1 beta	Homo sapiens	226-234
23786870-7	2013	The ATP changes can activate the purinergic receptor P2X ligand-gated ion channel 7 (P2X7R) signaling system to regulate IL-1beta secretion.	Adenosine Triphosphate	4-7	interleukin 1 beta	Homo sapiens	121-129
24285369-4	2013	Purified PMNs from diabetic patients who had been treated with glibenclamide (an ATP-sensitive potassium channel blocker for anti-diabetes therapy), showed reduction of interleukin (IL)-1beta and IL-8 secretion when exposed to B. pseudomallei.	Glyburide	63-76	interleukin 1 beta	Homo sapiens	169-191
24285369-6	2013	These findings suggest that glibenclamide might be responsible for the increased susceptibility of diabetic patients, with poor glycemic control, to bacterial infections as a result of its effect on reducing IL-1beta production by PMNs.	Glyburide	28-41	interleukin 1 beta	Homo sapiens	208-216
24009231-7	2013	Our findings also indicate that platelet-derived IL-1beta is chiefly released in microparticles through mechanisms dependent on mitochondrial reactive oxygen species-triggered NLRP3 inflammasomes.	Reactive Oxygen Species	142-165	interleukin 1 beta	Homo sapiens	49-57
23878142-0	2013	C3a modulates IL-1beta secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation.	Adenosine Triphosphate	66-69	interleukin 1 beta	Homo sapiens	14-22
23878142-3	2013	IL-1beta production by these cells requires Toll-like receptor (TLR) and adenosine triphosphate (ATP)-mediated P2X purinoceptor 7 (P2X7) signals, which together activate the inflammasome.	Adenosine Triphosphate	73-95	interleukin 1 beta	Homo sapiens	0-8
23878142-3	2013	IL-1beta production by these cells requires Toll-like receptor (TLR) and adenosine triphosphate (ATP)-mediated P2X purinoceptor 7 (P2X7) signals, which together activate the inflammasome.	Adenosine Triphosphate	97-100	interleukin 1 beta	Homo sapiens	0-8
23878142-7	2013	Mechanistically, C3a drives IL-1beta production in monocytes by controlling the release of intracellular ATP into the extracellular space via regulation of as-yet unidentified ATP-releasing channels in an extracellular signal-regulated kinase 1/2-dependent fashion.	Adenosine Triphosphate	105-108	interleukin 1 beta	Homo sapiens	28-36
24257035-6	2013	Mirtazapine increased IL-1beta, TNF-alpha and IL-22.	Mirtazapine	0-11	interleukin 1 beta	Homo sapiens	22-30
24089192-8	2013	In contrast, IL-1beta secretion is ablated by potassium, scavenging mitochondrial ROS, and both cathepsin B and caspase-1 inhibition.	Potassium	46-55	interleukin 1 beta	Homo sapiens	13-21
24089192-8	2013	In contrast, IL-1beta secretion is ablated by potassium, scavenging mitochondrial ROS, and both cathepsin B and caspase-1 inhibition.	Reactive Oxygen Species	82-85	interleukin 1 beta	Homo sapiens	13-21
23800300-13	2013	Normal RA value was observed in patients with POAG group connected with the 372 T/C TIMP1 (anova, p &lt; 0.05) and the -511 C/T IL-1beta (anova, p &lt; 0.05) genes polymorphisms occurrence.	Radium	7-9	interleukin 1 beta	Homo sapiens	128-136
24244322-3	2013	Here we examined in cultured human macrophages whether ethanol modulates the intracellular processes involved in the secretion of IL-1beta.	Ethanol	55-62	interleukin 1 beta	Homo sapiens	130-138
24244322-4	2013	RESULTS: Ethanol decreased dose-dependently the production of mature IL-1beta induced by activators of the NLRP3 inflammasome, i.e. ATP, cholesterol crystals, serum amyloid A and nigericin.	Ethanol	9-16	interleukin 1 beta	Homo sapiens	69-77
24244322-4	2013	RESULTS: Ethanol decreased dose-dependently the production of mature IL-1beta induced by activators of the NLRP3 inflammasome, i.e. ATP, cholesterol crystals, serum amyloid A and nigericin.	Adenosine Triphosphate	132-135	interleukin 1 beta	Homo sapiens	69-77
24244322-4	2013	RESULTS: Ethanol decreased dose-dependently the production of mature IL-1beta induced by activators of the NLRP3 inflammasome, i.e. ATP, cholesterol crystals, serum amyloid A and nigericin.	Cholesterol	137-148	interleukin 1 beta	Homo sapiens	69-77
24244322-4	2013	RESULTS: Ethanol decreased dose-dependently the production of mature IL-1beta induced by activators of the NLRP3 inflammasome, i.e. ATP, cholesterol crystals, serum amyloid A and nigericin.	Nigericin	179-188	interleukin 1 beta	Homo sapiens	69-77
24244322-6	2013	Moreover, secretion of IL-1beta was decreased in parallel with reduction of caspase-1 activation, demonstrating that ethanol inhibits inflammasome activation instead of synthesis of pro-IL-1beta.	Ethanol	117-124	interleukin 1 beta	Homo sapiens	23-31
24244322-8	2013	Ethanol also attenuated the secretion of IL-1beta triggered by synthetic double-stranded DNA, an activator of the AIM2 inflammasome.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	41-49
24649055-10	2013	The application of aspirin (0.1 mM) significantly inhibited the activation of ERK1/2 and NF-kappaB, the expression of TNF-alpha, IL-6, IL-1beta and MCP-1 genes and the secretion of TNF-alpha and IL-6.	Aspirin	19-26	interleukin 1 beta	Homo sapiens	135-143
24431314-10	2013	The IL-1B-511 genotype was determined in each patient by means of the phenol-chloroform technique, in order to enable DNA isolation, as well as by the PCR-RFLP method.	Phenol	70-76	interleukin 1 beta	Homo sapiens	4-9
23993677-1	2013	A series of 16 novel 1,2,4-triazine derivatives bearing hydrazone moiety (7a-7p) have been designed, synthesized and evaluated for their activity to inhibit IL-1beta and TNF-alpha production.	1,2,4-triazine	21-35	interleukin 1 beta	Homo sapiens	157-165
23993677-1	2013	A series of 16 novel 1,2,4-triazine derivatives bearing hydrazone moiety (7a-7p) have been designed, synthesized and evaluated for their activity to inhibit IL-1beta and TNF-alpha production.	Hydrazones	56-65	interleukin 1 beta	Homo sapiens	157-165
24200607-4	2013	Interleukin (IL)-1beta reportedly leads to accumulation of amyloid beta via nitric oxide stress in vitro.	Nitric Oxide	76-88	interleukin 1 beta	Homo sapiens	0-22
23968970-7	2013	Also, treatment with SB203580, an inhibitor of p38, reversed impairment induced by IL-1beta on conditioned fear behavior, indicating that this MAPK would be involved in the effect of the cytokine.	SB 203580	21-29	interleukin 1 beta	Homo sapiens	83-91
23968970-8	2013	We also showed that IL-1beta administration produced a decrease in glutamate release from dorsal hippocampus synaptosomes and that treatment with SB203580 partially reversed this effect.	Glutamic Acid	67-76	interleukin 1 beta	Homo sapiens	20-28
23968970-8	2013	We also showed that IL-1beta administration produced a decrease in glutamate release from dorsal hippocampus synaptosomes and that treatment with SB203580 partially reversed this effect.	SB 203580	146-154	interleukin 1 beta	Homo sapiens	20-28
23968970-9	2013	Our results indicated that IL-1beta-induced impairment in memory consolidation could be mediated by a decrease in glutamate release.	Glutamic Acid	114-123	interleukin 1 beta	Homo sapiens	27-35
23494261-4	2013	The ameliorating effect of propofol was associated with attenuated expression of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	Propofol	27-35	interleukin 1 beta	Homo sapiens	81-98
23968970-10	2013	This hypothesis is sustained by the fact that treatment with d-cycloserine (DCS), a partial agonist of the NMDA receptor, reversed the effect of IL-1beta on contextual fear memory.	Cycloserine	61-74	interleukin 1 beta	Homo sapiens	145-153
23968970-10	2013	This hypothesis is sustained by the fact that treatment with d-cycloserine (DCS), a partial agonist of the NMDA receptor, reversed the effect of IL-1beta on contextual fear memory.	Cycloserine	76-79	interleukin 1 beta	Homo sapiens	145-153
23494261-4	2013	The ameliorating effect of propofol was associated with attenuated expression of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	Propofol	27-35	interleukin 1 beta	Homo sapiens	100-108
23494261-6	2013	Results showed that propofol could block the stimulatory effect of IL-1beta and TNF-alpha on AQP-4 expression in cultured astrocytes.	Propofol	20-28	interleukin 1 beta	Homo sapiens	67-75
23494261-7	2013	We also found that both NFkappaB and p38/MAPK pathways were involved in IL-1beta and TNF-alpha-induced AQP-4 expression and that propofol functions as a dual inhibitor of NFkappaB and p38/MAPK pathways.	Propofol	129-137	interleukin 1 beta	Homo sapiens	72-80
23494261-9	2013	Propofol modulates acute AQP-4 expression by attenuating IL-1beta and TNF-alpha expression and inhibiting IL-1beta and TNF-alpha induced AQP-4 expression.	Propofol	0-8	interleukin 1 beta	Homo sapiens	57-65
23494261-9	2013	Propofol modulates acute AQP-4 expression by attenuating IL-1beta and TNF-alpha expression and inhibiting IL-1beta and TNF-alpha induced AQP-4 expression.	Propofol	0-8	interleukin 1 beta	Homo sapiens	106-114
24142467-3	2013	Serum-deprived (48 h) PASMC were stimulated with IL-1beta alone or with NO donor, L-arginine and/or NO synthase inhibitor L-NAME for 4 and 24 h. IL-1beta did not affect PlGF release, but augmented VEGF release (2.4-fold) after 24 h. VEGF release was inhibited by L-NAME (531.8 +- 52 pg/ml), but restored and further elevated by L-arginine (1,529 +- 287 pg/ml).	pasmc	22-27	interleukin 1 beta	Homo sapiens	145-153
23949386-0	2013	Interleukin-1beta plays key roles in LPA-induced amplification of LPA production in neuropathic pain model.	lysophosphatidic acid	37-40	interleukin 1 beta	Homo sapiens	0-17
23949386-0	2013	Interleukin-1beta plays key roles in LPA-induced amplification of LPA production in neuropathic pain model.	lysophosphatidic acid	66-69	interleukin 1 beta	Homo sapiens	0-17
23949386-5	2013	LPA injection rapidly increased the expression of IL-1beta mRNA in the spinal dorsal horn as early as 0.5 h after injection, and the level reached peak at 2 h. Through a developed quantitative mass spectrometry for detecting LPA species, the elevated levels of 18:1, 16:0, and 18:0 LPA in the spinal dorsal horn were observed at 3 h after 18:1 LPA injection and this elevation was completely blocked by the pretreatment of IL-1beta-neutralizing antibody.	lysophosphatidic acid	0-3	interleukin 1 beta	Homo sapiens	50-58
23949386-5	2013	LPA injection rapidly increased the expression of IL-1beta mRNA in the spinal dorsal horn as early as 0.5 h after injection, and the level reached peak at 2 h. Through a developed quantitative mass spectrometry for detecting LPA species, the elevated levels of 18:1, 16:0, and 18:0 LPA in the spinal dorsal horn were observed at 3 h after 18:1 LPA injection and this elevation was completely blocked by the pretreatment of IL-1beta-neutralizing antibody.	lysophosphatidic acid	0-3	interleukin 1 beta	Homo sapiens	423-431
23949386-5	2013	LPA injection rapidly increased the expression of IL-1beta mRNA in the spinal dorsal horn as early as 0.5 h after injection, and the level reached peak at 2 h. Through a developed quantitative mass spectrometry for detecting LPA species, the elevated levels of 18:1, 16:0, and 18:0 LPA in the spinal dorsal horn were observed at 3 h after 18:1 LPA injection and this elevation was completely blocked by the pretreatment of IL-1beta-neutralizing antibody.	lysophosphatidic acid	225-228	interleukin 1 beta	Homo sapiens	50-58
23949386-5	2013	LPA injection rapidly increased the expression of IL-1beta mRNA in the spinal dorsal horn as early as 0.5 h after injection, and the level reached peak at 2 h. Through a developed quantitative mass spectrometry for detecting LPA species, the elevated levels of 18:1, 16:0, and 18:0 LPA in the spinal dorsal horn were observed at 3 h after 18:1 LPA injection and this elevation was completely blocked by the pretreatment of IL-1beta-neutralizing antibody.	lysophosphatidic acid	225-228	interleukin 1 beta	Homo sapiens	423-431
23949386-8	2013	Similarly, IL-1beta-neutralizing antibody reversed LPA-induced neuropathic pain-like behavior.	lysophosphatidic acid	51-54	interleukin 1 beta	Homo sapiens	11-19
23949386-9	2013	These findings suggest that the early release of IL-1beta is involved in LPA-induced amplification of LPA production, which underlies the initial mechanisms of LPA-induced neuropathic pain.	lysophosphatidic acid	73-76	interleukin 1 beta	Homo sapiens	49-57
23949386-9	2013	These findings suggest that the early release of IL-1beta is involved in LPA-induced amplification of LPA production, which underlies the initial mechanisms of LPA-induced neuropathic pain.	lysophosphatidic acid	102-105	interleukin 1 beta	Homo sapiens	49-57
23949386-9	2013	These findings suggest that the early release of IL-1beta is involved in LPA-induced amplification of LPA production, which underlies the initial mechanisms of LPA-induced neuropathic pain.	lysophosphatidic acid	102-105	interleukin 1 beta	Homo sapiens	49-57
24142467-0	2013	Nitric oxide donors augment interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	28-45
24142467-4	2013	IL-1beta up-regulated VEGF mRNA (1.8-fold) and this response was attenuated by L-NAME (1.1-fold) and augmented by L-arginine (3.8-fold) at 4 h. Restoration of a NO pathway by L-arginine in L-NAME-treated cells resulted in elevated VEGF mRNA levels (2.2-fold).	NG-Nitroarginine Methyl Ester	79-85	interleukin 1 beta	Homo sapiens	0-8
24142467-4	2013	IL-1beta up-regulated VEGF mRNA (1.8-fold) and this response was attenuated by L-NAME (1.1-fold) and augmented by L-arginine (3.8-fold) at 4 h. Restoration of a NO pathway by L-arginine in L-NAME-treated cells resulted in elevated VEGF mRNA levels (2.2-fold).	Arginine	114-124	interleukin 1 beta	Homo sapiens	0-8
24142467-4	2013	IL-1beta up-regulated VEGF mRNA (1.8-fold) and this response was attenuated by L-NAME (1.1-fold) and augmented by L-arginine (3.8-fold) at 4 h. Restoration of a NO pathway by L-arginine in L-NAME-treated cells resulted in elevated VEGF mRNA levels (2.2-fold).	Arginine	175-185	interleukin 1 beta	Homo sapiens	0-8
24142467-4	2013	IL-1beta up-regulated VEGF mRNA (1.8-fold) and this response was attenuated by L-NAME (1.1-fold) and augmented by L-arginine (3.8-fold) at 4 h. Restoration of a NO pathway by L-arginine in L-NAME-treated cells resulted in elevated VEGF mRNA levels (2.2-fold).	NG-Nitroarginine Methyl Ester	189-195	interleukin 1 beta	Homo sapiens	0-8
24142467-5	2013	[(3)H]Thymidine incorporation assay revealed enhanced porcine pulmonary artery endothelial cell proliferation in response to IL-1beta, VEGF and PlGF, and this mitogenic effect was not influenced via the NO pathway.	Thymidine	6-15	interleukin 1 beta	Homo sapiens	125-133
23958972-1	2013	The immunotoxicity of the synthetic pyrethroid alpha-cypermethrin (alphaCYP) was assessed in 30 occupationally exposed greenhouse workers and 30 non-exposed controls by comparing plasma levels of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha, TNF-beta and INF-gamma.	cypermethrin	47-65	interleukin 1 beta	Homo sapiens	196-204
23871663-7	2013	RESULTS: RV-16 infection impaired dexamethasone-dependent (1) inhibition of IL-1beta-induced CXCL8 release, (2) induction of mitogen-activated protein kinase phosphatase 1 gene expression, and (3) binding of GR to GREs in airway epithelial cells.	Dexamethasone	34-47	interleukin 1 beta	Homo sapiens	76-84
23454144-6	2013	ROS are also involved in the activation of the NLRP3/NALP3 inflammasome, which is required to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18, which are all integral to the process of dendritic cells mobilization, migration and functional maturation.	Reactive Oxygen Species	0-3	interleukin 1 beta	Homo sapiens	162-170
23370294-6	2013	Median serum levels of cytokines IL-1alpha, IL-1beta, IL-1Ra, IL-6 and TNF-alpha in the OSFE group were: 1.077, 1.745, 25.640, 0.602 and 12.768 pg/ml, respectively.	osfe	88-92	interleukin 1 beta	Homo sapiens	44-52
23934279-5	2013	H2O2 significantly reduced FP-induced GR nuclear localization (3.4+-0.51- vs. 5.7+-0.85-fold increase, P&lt;0.05) and suppression of IL-1beta-induced CXCL8 (62.3+-2.3 vs. 85.1+-7.0%, P&lt;0.05).	Hydrogen Peroxide	0-4	interleukin 1 beta	Homo sapiens	133-141
24038428-6	2013	TTX inhibited LPS-induced NF-kappaB activation, expression of TNF-alpha, IL-1beta and inducible nitric oxide synthase, and NO production.	Tetrodotoxin	0-3	interleukin 1 beta	Homo sapiens	73-81
24007780-5	2013	Following vitamin D loading at 3 months, the relationships between some of the cytokines changed (TNF-alpha and MCP-1: r=0.38, p=0.017, IL-1beta and IL-17: r=0.3, p=0.06).	Vitamin D	10-19	interleukin 1 beta	Homo sapiens	136-144
23632235-6	2013	RESULTS: In the CLA group, the mean serum TNF-alpha, IL-1beta, hsCRP, MMP-9, and MMP-2 levels reduced insignificantly.	Linoleic Acids, Conjugated	16-19	interleukin 1 beta	Homo sapiens	53-61
24079335-6	2013	Furthermore, rhRLX administration attenuated the increase in leucocyte activation, as suggested by inhibition of myeloperoxidase activity, intercellular-adhesion-molecule-1 expression, interleukin (IL)-1beta, IL-18 and tumour necrosis factor-alpha production as well as increase in IL-10 production.	rhrlx	13-18	interleukin 1 beta	Homo sapiens	185-207
23916117-7	2013	In cancer NAF samples (containing higher amounts of aluminium salts) we also found a significantly increased levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-12 p70, and TNF-alpha) and chemoattractant CC and CXC chemokines (IL-8, MIP-1alpha and MCP-1).	aluminium salts	52-67	interleukin 1 beta	Homo sapiens	147-155
23978396-6	2013	IL-1beta production was significantly decreased by PRM, CBZ, LEV, LTG, OXC, PB and lithium.	Carbamazepine	56-59	interleukin 1 beta	Homo sapiens	0-8
24006511-4	2013	Palmitate and stearate, both SFAs, triggered IL-1beta secretion in a caspase-1/ASC/NLRP3-dependent pathway.	Palmitates	0-9	interleukin 1 beta	Homo sapiens	45-53
24006511-4	2013	Palmitate and stearate, both SFAs, triggered IL-1beta secretion in a caspase-1/ASC/NLRP3-dependent pathway.	Stearates	14-22	interleukin 1 beta	Homo sapiens	45-53
24006511-6	2013	In addition, they totally prevented the IL-1beta release induced by SFAs and, with less efficiency, by a broad range of NLRP3 inducers, including nigericin, alum, and monosodium urate.	Nigericin	146-155	interleukin 1 beta	Homo sapiens	40-48
24006511-6	2013	In addition, they totally prevented the IL-1beta release induced by SFAs and, with less efficiency, by a broad range of NLRP3 inducers, including nigericin, alum, and monosodium urate.	aluminum sulfate	157-161	interleukin 1 beta	Homo sapiens	40-48
24006511-6	2013	In addition, they totally prevented the IL-1beta release induced by SFAs and, with less efficiency, by a broad range of NLRP3 inducers, including nigericin, alum, and monosodium urate.	Uric Acid	167-183	interleukin 1 beta	Homo sapiens	40-48
24006511-8	2013	These results provide a new anti-inflammatory mechanism of UFAs by preventing the activation of the NLRP3 inflammasome and, therefore, IL-1beta processing.	Fatty Acids, Unsaturated	59-63	interleukin 1 beta	Homo sapiens	135-143
24012176-3	2013	The assessment was performed under basal conditions or following treatment with interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, or their combinations, in cells exposed to exogenous kynurenine.	Kynurenine	222-232	interleukin 1 beta	Homo sapiens	139-161
23978396-6	2013	IL-1beta production was significantly decreased by PRM, CBZ, LEV, LTG, OXC, PB and lithium.	Levetiracetam	61-64	interleukin 1 beta	Homo sapiens	0-8
23978396-6	2013	IL-1beta production was significantly decreased by PRM, CBZ, LEV, LTG, OXC, PB and lithium.	Lamotrigine	66-69	interleukin 1 beta	Homo sapiens	0-8
23978396-6	2013	IL-1beta production was significantly decreased by PRM, CBZ, LEV, LTG, OXC, PB and lithium.	Oxcarbazepine	71-74	interleukin 1 beta	Homo sapiens	0-8
23978396-6	2013	IL-1beta production was significantly decreased by PRM, CBZ, LEV, LTG, OXC, PB and lithium.	Phenobarbital	76-78	interleukin 1 beta	Homo sapiens	0-8
23978396-6	2013	IL-1beta production was significantly decreased by PRM, CBZ, LEV, LTG, OXC, PB and lithium.	Lithium	83-90	interleukin 1 beta	Homo sapiens	0-8
23242626-5	2013	RESULTS: Andrographolide tested in these in vitro studies was found be an effective antiarthritic agent, as evidenced by potent inhibition of MMP-1, 3, and 13 and iNOS expression, as well as upregulation of TIMP-1 in IL-1beta-stimulated human articular chondrocytes (p &lt; 0.05).	andrographolide	9-24	interleukin 1 beta	Homo sapiens	217-225
23850530-5	2013	RESULTS: Hypoxia (2% O2) and anoxia (&lt;1% O2), acidosis (pH 6.2) and 10 ng/ml IL-1beta reduced HOAC cell viability and increased GAG media levels.	Oxygen	21-23	interleukin 1 beta	Homo sapiens	80-88
23850530-5	2013	RESULTS: Hypoxia (2% O2) and anoxia (&lt;1% O2), acidosis (pH 6.2) and 10 ng/ml IL-1beta reduced HOAC cell viability and increased GAG media levels.	Oxygen	44-46	interleukin 1 beta	Homo sapiens	80-88
23850530-5	2013	RESULTS: Hypoxia (2% O2) and anoxia (&lt;1% O2), acidosis (pH 6.2) and 10 ng/ml IL-1beta reduced HOAC cell viability and increased GAG media levels.	Acetic Acid	97-101	interleukin 1 beta	Homo sapiens	80-88
23850530-5	2013	RESULTS: Hypoxia (2% O2) and anoxia (&lt;1% O2), acidosis (pH 6.2) and 10 ng/ml IL-1beta reduced HOAC cell viability and increased GAG media levels.	gag media	131-140	interleukin 1 beta	Homo sapiens	80-88
23850530-6	2013	Acidosis and IL-1beta increased nitrite/nitrate release, but increases were moderate at 2% O2 and significantly reduced at &lt;1% O2.	Nitrites	32-39	interleukin 1 beta	Homo sapiens	13-21
23850530-6	2013	Acidosis and IL-1beta increased nitrite/nitrate release, but increases were moderate at 2% O2 and significantly reduced at &lt;1% O2.	Nitrates	40-47	interleukin 1 beta	Homo sapiens	13-21
23850530-6	2013	Acidosis and IL-1beta increased nitrite/nitrate release, but increases were moderate at 2% O2 and significantly reduced at &lt;1% O2.	Oxygen	130-132	interleukin 1 beta	Homo sapiens	13-21
23850530-8	2013	At 48 h cellular ROS levels were increased by acidosis and IL-1beta but reduced in hypoxia and anoxia.	Reactive Oxygen Species	17-20	interleukin 1 beta	Homo sapiens	59-67
23850530-11	2013	GSH/GSSG ratio was reduced in low oxygen conditions, acidosis and IL-1beta.	Glutathione	0-3	interleukin 1 beta	Homo sapiens	66-74
23850530-11	2013	GSH/GSSG ratio was reduced in low oxygen conditions, acidosis and IL-1beta.	Glutathione Disulfide	4-8	interleukin 1 beta	Homo sapiens	66-74
23957020-7	2013	RESULTS: Levels of interleukin (IL)-1beta were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH.	ctth	101-105	interleukin 1 beta	Homo sapiens	19-41
23938763-3	2013	IL-1beta signaling was blocked by systemic administration of two antiinflammatory drugs, namely human recombinant IL-1 receptor antagonist (anakinra), the naturally occurring and clinically used competitive IL-1 receptor type 1 antagonist, and VX-765 a specific non-peptide inhibitor of IL-1beta cleavage and release.	belnacasan	244-250	interleukin 1 beta	Homo sapiens	0-8
23242626-6	2013	The mechanism of andrographolide"s inhibitory effects was mediated by attenuating the activation of NF-kappaB in human chondrocytes in the presence of IL-1beta.	andrographolide	17-32	interleukin 1 beta	Homo sapiens	151-159
24286132-8	2013	RESULTS: Both FN-fs and IL-1beta increased NO, PGE2 and MMP production (all P&lt; 0.001).	Dinoprostone	47-51	interleukin 1 beta	Homo sapiens	24-32
24286132-10	2013	Whilst FN-f reduced GAG synthesis at all oxygen tension, the effect of IL-1beta was significant at 1% oxygen tension.	Oxygen	102-108	interleukin 1 beta	Homo sapiens	71-79
24286132-12	2013	In unstrained constructs, FN-f was more effective than IL-1beta at 5% oxygen tension and increased production of NO, PGE2, MMP, IL-1beta, IL-6 and TNFalpha.	Oxygen	70-76	interleukin 1 beta	Homo sapiens	55-63
24286132-14	2013	CONCLUSIONS: The present findings revealed that FN-fs are more potent than IL-1beta in exerting catabolic effects dependent on oxygen tension via iNOS and COX-2 upregulation.	Oxygen	127-133	interleukin 1 beta	Homo sapiens	75-83
24198853-2	2013	This response is largely mediated by immune and bone cells (monocytes/macrophages and osteoclasts, respectively), that in the presence of implant debris (e.g. metal particles and ions), release pro-inflammatory cytokines such as IL-1beta, TNF-alpha, and IL-6.	Metals	159-164	interleukin 1 beta	Homo sapiens	229-237
24157941-0	2013	Adiponectin and metformin additively attenuate IL1beta-induced malignant potential of colon cancer.	Metformin	16-25	interleukin 1 beta	Homo sapiens	47-54
24198853-6	2013	Particulate Co-alloy challenge induced &gt;1000 pg/ml of IL-1beta and TNF-alpha, in monocytes and &lt;50pg/mL IL-1beta and TNF-alpha in osteoclasts.	Cobalt	12-14	interleukin 1 beta	Homo sapiens	57-65
24198853-6	2013	Particulate Co-alloy challenge induced &gt;1000 pg/ml of IL-1beta and TNF-alpha, in monocytes and &lt;50pg/mL IL-1beta and TNF-alpha in osteoclasts.	Cobalt	12-14	interleukin 1 beta	Homo sapiens	110-118
24198853-6	2013	Particulate Co-alloy challenge induced &gt;1000 pg/ml of IL-1beta and TNF-alpha, in monocytes and &lt;50pg/mL IL-1beta and TNF-alpha in osteoclasts.	Alloys	15-20	interleukin 1 beta	Homo sapiens	57-65
24198853-6	2013	Particulate Co-alloy challenge induced &gt;1000 pg/ml of IL-1beta and TNF-alpha, in monocytes and &lt;50pg/mL IL-1beta and TNF-alpha in osteoclasts.	Alloys	15-20	interleukin 1 beta	Homo sapiens	110-118
24198853-7	2013	Cobalt ions induced &gt;3000pg/mL IL-1beta and TNF-alpha in monocytes/macrophages and &lt;50pg/mL IL-1beta and TNF-alpha in osteoclasts.	Cobalt	0-6	interleukin 1 beta	Homo sapiens	34-42
24198853-7	2013	Cobalt ions induced &gt;3000pg/mL IL-1beta and TNF-alpha in monocytes/macrophages and &lt;50pg/mL IL-1beta and TNF-alpha in osteoclasts.	Cobalt	0-6	interleukin 1 beta	Homo sapiens	98-106
24043885-0	2013	Inflammasome-mediated secretion of IL-1beta in human monocytes through TLR2 activation; modulation by dietary fatty acids.	dietary fatty acids	102-121	interleukin 1 beta	Homo sapiens	35-43
24043885-5	2013	Activation of TLR2 by palmitic acid leads to expression of pro-IL-1beta that is cleaved by caspase-1, which is constitutively present in monocytes, to release mature IL-1beta.	Palmitic Acid	22-35	interleukin 1 beta	Homo sapiens	63-71
24043885-5	2013	Activation of TLR2 by palmitic acid leads to expression of pro-IL-1beta that is cleaved by caspase-1, which is constitutively present in monocytes, to release mature IL-1beta.	Palmitic Acid	22-35	interleukin 1 beta	Homo sapiens	59-71
24043885-6	2013	Our results reveal mechanistic insight about how palmitic acid activates TLR2, upregulates NALP3 expression, and induces inflammasome-mediated IL-1beta production in human monocytes, which can trigger enhanced inflammation in peripheral tissues, and suggest that these processes are dynamically modulated by the types of dietary fat we consume.	Palmitic Acid	49-62	interleukin 1 beta	Homo sapiens	143-151
23994388-0	2013	Long-term nicotine treatment suppresses IL-1beta release and attenuates substance P- and 5-HT-evoked Ca2+ responses in astrocytes.	Nicotine	10-18	interleukin 1 beta	Homo sapiens	40-48
23970554-4	2013	When cultured with IL-1beta, marrow-derived MSCs from 8 of 10 human subjects deposited copious hydroxyapatite, in which authenticity was confirmed by Fourier transform infrared spectroscopy.	Durapatite	95-109	interleukin 1 beta	Homo sapiens	19-27
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	interleukin 1 beta	Homo sapiens	172-189
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	interleukin 1 beta	Homo sapiens	191-199
23830817-7	2013	The results showed that both 1-ribofuranosyl-s-triazin-2(1H)-one and pistillarin exhibited significant immunosuppressive effects on phytohemagglutinin (PHA)-stimulated human PBMCs by inhibiting [methyl-(3)H]-thymidine uptake and inflammatory cytokines productions such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, interferon (IFN)-gamma and IL-1beta.	1-ribofuranosyl-s-triazin-2(1H)-one	29-64	interleukin 1 beta	Homo sapiens	355-363
23830817-7	2013	The results showed that both 1-ribofuranosyl-s-triazin-2(1H)-one and pistillarin exhibited significant immunosuppressive effects on phytohemagglutinin (PHA)-stimulated human PBMCs by inhibiting [methyl-(3)H]-thymidine uptake and inflammatory cytokines productions such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, interferon (IFN)-gamma and IL-1beta.	pistillarin	69-80	interleukin 1 beta	Homo sapiens	355-363
23994388-1	2013	The aim of this study was to investigate whether short- or long-term nicotine treatment, had an influence on Ca(2+)-induced intracellular Ca(2+) release in astrocytes co-cultured with microvascular endothelial cells, and if the release of interleukin-1beta (IL-1beta) changed during this treatment.	Nicotine	69-77	interleukin 1 beta	Homo sapiens	239-256
23994388-1	2013	The aim of this study was to investigate whether short- or long-term nicotine treatment, had an influence on Ca(2+)-induced intracellular Ca(2+) release in astrocytes co-cultured with microvascular endothelial cells, and if the release of interleukin-1beta (IL-1beta) changed during this treatment.	Nicotine	69-77	interleukin 1 beta	Homo sapiens	258-266
23994388-5	2013	The results show that long-term nicotine treatment had no influence on nicotine-evoked Ca(2+) transients or protein expression of the alpha7-nAChR, but had with a decreased IL-1beta release.	Nicotine	32-40	interleukin 1 beta	Homo sapiens	173-181
23856068-0	2013	Interleukin-1beta alters the sensitivity of cannabinoid CB1 receptors controlling glutamate transmission in the striatum.	Glutamic Acid	82-91	interleukin 1 beta	Homo sapiens	0-17
23706318-8	2013	IL-1beta, IL-10, IL-18 and TNF-alpha upregulated the expression of cardiac structural proteins and increased the ROS level in differentiating EBs.	Reactive Oxygen Species	113-116	interleukin 1 beta	Homo sapiens	0-8
23706318-11	2013	IL-1beta, IL-10, IL-18 and TNF-alpha enhance cardiac differentiation and ROS may serve as the messenger in cardiogenic signaling from these cytokines.	Reactive Oxygen Species	73-76	interleukin 1 beta	Homo sapiens	0-8
23856068-3	2013	Furthermore, IL1beta has also been shown to control the sensitivity of cannabinoid CB1 receptors controlling GABA transmission (CB1Rs(GABA)) in the striatum.	gamma-Aminobutyric Acid	109-113	interleukin 1 beta	Homo sapiens	13-20
23856068-3	2013	Furthermore, IL1beta has also been shown to control the sensitivity of cannabinoid CB1 receptors controlling GABA transmission (CB1Rs(GABA)) in the striatum.	gamma-Aminobutyric Acid	134-138	interleukin 1 beta	Homo sapiens	13-20
23856068-5	2013	Our results show that the sensitivity of CB1Rs(glu) is fully blocked in the presence of IL1beta in corticostriatal brain slices, and that the protein kinase C/TRPV1 pathway is involved in this effect.	Glutamic Acid	47-50	interleukin 1 beta	Homo sapiens	88-95
24455185-2	2013	Neolactoferrin enhanced the production of IL-1beta.	neolactoferrin	0-14	interleukin 1 beta	Homo sapiens	42-50
23349129-10	2013	GNF351 inhibited the recruitment of AHR to the promoters of IL1B and IL6 confirming occupancy of AHR at these promoters is required for enhanced inflammatory signalling.	N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine	0-6	interleukin 1 beta	Homo sapiens	60-64
24008845-2	2013	Here, we show that physiologically relevant levels of cyclic dinucleotides also stimulate a robust secretion of IL-1beta through the NLRP3 inflammasome.	cyclic dinucleotides	54-74	interleukin 1 beta	Homo sapiens	112-120
23611467-2	2013	It is promoted through the inflammasome, a molecular machine that produces IL (interleukin)-1beta in response to cholesterol crystal accumulation in macrophages.	Cholesterol	113-124	interleukin 1 beta	Homo sapiens	75-97
24079737-4	2013	Occlusion with a water-impermeable plastic membrane partially blocked the increases in cortisol secretion and CYP11B1 and IL-1beta mRNA expression in the dry condition.	Water	17-22	interleukin 1 beta	Homo sapiens	122-130
24028591-8	2013	The concentrations of SP and IL-1beta were significantly increased in cells incubated with NEP inhibitors and, to a lesser extent, in cells incubated with ECE-1/NEP inhibitors, compared with controls (cells incubated with LPS or nicotine alone).	Nicotine	229-237	interleukin 1 beta	Homo sapiens	29-37
22767422-12	2013	IL-1beta elevated basal firing, and this was lost after tetrodotoxin blockade of sodium channels.	Tetrodotoxin	56-68	interleukin 1 beta	Homo sapiens	0-8
23934131-0	2013	Kaempferol inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs.	kaempferol	0-10	interleukin 1 beta	Homo sapiens	20-28
23838114-10	2013	We found that piperine inhibited the production of PGE2 and NO induced by IL-1beta.	piperine	14-22	interleukin 1 beta	Homo sapiens	74-82
23838114-10	2013	We found that piperine inhibited the production of PGE2 and NO induced by IL-1beta.	Dinoprostone	51-55	interleukin 1 beta	Homo sapiens	74-82
23838114-11	2013	Piperine significantly decreased the IL-1beta-stimulated gene expression and production of MMP-3, MMP-13, iNOS and COX-2 in human OA chondrocytes.	piperine	0-8	interleukin 1 beta	Homo sapiens	37-45
23838114-12	2013	Piperine inhibited the IL-1beta-mediated activation of NF-kappaB by suppressing the degradation of its inhibitory protein IkappaBalpha in the cytoplasm.	piperine	0-8	interleukin 1 beta	Homo sapiens	23-31
23944357-4	2013	We found that peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, and increased IL-10 production.	verticine	14-21	interleukin 1 beta	Homo sapiens	113-121
23934131-0	2013	Kaempferol inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs.	Dinoprostone	125-129	interleukin 1 beta	Homo sapiens	20-28
23934131-3	2013	The aim of the present study was to determine the effects of kaempferol on the interleukin-1beta (IL-1beta)-induced proliferation of RASFs and the production of MMPs, COX and prostaglandin E2 (PGE2) by RASFs.	kaempferol	61-71	interleukin 1 beta	Homo sapiens	79-96
23934131-3	2013	The aim of the present study was to determine the effects of kaempferol on the interleukin-1beta (IL-1beta)-induced proliferation of RASFs and the production of MMPs, COX and prostaglandin E2 (PGE2) by RASFs.	kaempferol	61-71	interleukin 1 beta	Homo sapiens	98-106
23934131-6	2013	Kaempferol inhibited the proliferation of both unstimulated and IL-1beta-stimulated RASFs, as well as the mRNA and protein expression of MMP-1, MMP-3, COX-2 and PGE2 induced by IL-1beta.	kaempferol	0-10	interleukin 1 beta	Homo sapiens	64-72
23934131-6	2013	Kaempferol inhibited the proliferation of both unstimulated and IL-1beta-stimulated RASFs, as well as the mRNA and protein expression of MMP-1, MMP-3, COX-2 and PGE2 induced by IL-1beta.	kaempferol	0-10	interleukin 1 beta	Homo sapiens	177-185
23934131-6	2013	Kaempferol inhibited the proliferation of both unstimulated and IL-1beta-stimulated RASFs, as well as the mRNA and protein expression of MMP-1, MMP-3, COX-2 and PGE2 induced by IL-1beta.	Dinoprostone	161-165	interleukin 1 beta	Homo sapiens	177-185
23934131-7	2013	Kaempferol also inhibited the phosphorylation of ERK-1/2, p38 and JNK, as well as the activation of NF-kappaB induced by IL-1beta.	kaempferol	0-10	interleukin 1 beta	Homo sapiens	121-129
23835558-9	2013	Both 10 or 100 mug/ml Rb1 inhibited the effect of IL-1beta on chondrocytes by decreasing levels of PGE2, NO(2)-, MMP-13, COX-2, iNOS, caspase-3 and PARP and increasing aggrecan and Col2A1 gene expression levels, to block IL-1beta-induced cell inflammation and apoptosis.	Dinoprostone	99-103	interleukin 1 beta	Homo sapiens	50-58
23733596-9	2013	Results showed that supplementation with LC and Na2S reduced NF-kappaB phosphorylation and the secretion of TNF-alpha, MCP-1, IL-8, IL-1beta, and IP-10.	sodium sulfide	48-52	interleukin 1 beta	Homo sapiens	132-140
23845419-10	2013	The release of IL-1beta was due to polyI:C induced cell death that occurred through a caspase-4 dependent manner.	Poly I-C	35-42	interleukin 1 beta	Homo sapiens	15-23
23856614-4	2013	Effects of vorinostat on IL-1beta-induced gene and protein expression of iNOS, MMP-1, MMP-13 and tissue inhibitors of metalloproteinase-1 (TIMP-1) were verified by quantitative real time-PCR and Western blot analysis.	Vorinostat	11-21	interleukin 1 beta	Homo sapiens	25-33
23856614-8	2013	In addition, the release of NO, MMP-1 and MMP-13 secreted from IL-1beta stimulated chondrocytes was also suppressed by vorinostat.	Vorinostat	119-129	interleukin 1 beta	Homo sapiens	63-71
23856614-9	2013	Interestingly, vorinostat selectively inhibited IL-1beta-induced p38 and ERK1/2 activation without affecting JNK activation.	Vorinostat	15-25	interleukin 1 beta	Homo sapiens	48-56
23838114-14	2013	Piperine can effectively abrogate the IL-1beta-induced over-expression of inflammatory mediators; suggesting that piperine may be a potential agent in the treatment of OA.	piperine	0-8	interleukin 1 beta	Homo sapiens	38-46
23838114-14	2013	Piperine can effectively abrogate the IL-1beta-induced over-expression of inflammatory mediators; suggesting that piperine may be a potential agent in the treatment of OA.	piperine	114-122	interleukin 1 beta	Homo sapiens	38-46
23856614-2	2013	In present study, we investigated whether vorinostat can inhibit the catabolic effects of IL-1beta in vitro, especially the inhibition of MMPs and inducible nitric oxide synthase (iNOS) through the attenuation of nuclear factor kappa-B (NF-kappaB) and mitogen activated protein kinase (MAPK) pathways in human chondrocytes.	Vorinostat	42-52	interleukin 1 beta	Homo sapiens	90-98
23845419-12	2013	In addition, the apoptotic caspases -8, -9 and -3/7 were activated by polyI:C. CONCLUSION: TLR3 stimulation in keratinocytes induces a caspase-4 dependent release of pro-IL-1beta, but further processing to active IL-1beta is limited.	Poly I	70-75	interleukin 1 beta	Homo sapiens	166-178
23845419-12	2013	In addition, the apoptotic caspases -8, -9 and -3/7 were activated by polyI:C. CONCLUSION: TLR3 stimulation in keratinocytes induces a caspase-4 dependent release of pro-IL-1beta, but further processing to active IL-1beta is limited.	Poly I	70-75	interleukin 1 beta	Homo sapiens	170-178
23995233-2	2013	Cholesterol crystals are metabolic signals that trigger sterile inflammation in atherosclerosis, presumably by activating inflammasomes for IL-1beta production.	Cholesterol	0-11	interleukin 1 beta	Homo sapiens	140-148
23628437-7	2013	RESULTS: Magnesium sulfate at 5 and 10 mmol/L significantly inhibited the release of nitric oxide, prostaglandin E2, interleukin 1beta, and tumor necrosis factor alpha, and the expression of inducible nitric oxide synthase mRNA in LPS-activated microglia.	Magnesium Sulfate	9-26	interleukin 1 beta	Homo sapiens	117-134
24014650-8	2013	IL-1beta also promoted binding of serine-phosphorylated signal transducer and activator of transcription-1 (STAT1) (Ser727) but not tyrosine-phosphorylated STAT1 (Tyr701) to GAS elements.	Serine	34-40	interleukin 1 beta	Homo sapiens	0-8
23918204-6	2013	Although IFN-gamma alone had no effect, it potentiated IL-1beta-induced ROS production in a time-dependent manner.	Reactive Oxygen Species	72-75	interleukin 1 beta	Homo sapiens	55-63
23918204-7	2013	One of the sources of ROS in IL-1beta-activated astrocytes was from increased superoxide production in mitochondria accompanied by enhanced manganese superoxide dismutase and inhibited catalase expression.	Reactive Oxygen Species	22-25	interleukin 1 beta	Homo sapiens	29-37
23995233-5	2013	Fatty acid-induced mitochondrial uncoupling abrogated IL-1beta secretion, which deviated the cholesterol crystal-elicited response toward selective production of IL-1alpha.	Fatty Acids	0-10	interleukin 1 beta	Homo sapiens	54-62
23918204-7	2013	One of the sources of ROS in IL-1beta-activated astrocytes was from increased superoxide production in mitochondria accompanied by enhanced manganese superoxide dismutase and inhibited catalase expression.	Superoxides	78-88	interleukin 1 beta	Homo sapiens	29-37
23918204-9	2013	Glutamate uptake, which represents one of the most important methods of astrocytes to prevent excitotoxicity, was down-regulated in IL-1beta-activated astrocytes, and was further suppressed in the presence of IFN-gamma; IFN-gamma itself exerted minimal effect.	Glutamic Acid	0-9	interleukin 1 beta	Homo sapiens	132-140
23995233-5	2013	Fatty acid-induced mitochondrial uncoupling abrogated IL-1beta secretion, which deviated the cholesterol crystal-elicited response toward selective production of IL-1alpha.	Cholesterol	93-104	interleukin 1 beta	Homo sapiens	54-62
23918204-10	2013	Elevated levels of 8-isoprostane in IL-1beta +- IFN-gamma-activated human astrocytes indicate downstream lipid peroxidation.	8-epi-prostaglandin F2alpha	19-32	interleukin 1 beta	Homo sapiens	36-44
24086524-4	2013	RESULTS: Expression array analysis revealed massive upregulation of genes encoding stress-responsive proteins (HSPA1L, EGR1, IL-6, IL-1beta, TNSF10 and TNFalpha) in the styrene-exposed group; the levels of cytokines released were further confirmed in serum.	Styrene	169-176	interleukin 1 beta	Homo sapiens	131-139
23918204-11	2013	Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes.	diphenyleneiodonium	18-37	interleukin 1 beta	Homo sapiens	52-60
23918204-11	2013	Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes.	Reactive Oxygen Species	82-85	interleukin 1 beta	Homo sapiens	52-60
23918204-11	2013	Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes.	8-epi-prostaglandin F2alpha	145-158	interleukin 1 beta	Homo sapiens	52-60
23918204-11	2013	Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes.	Reactive Oxygen Species	198-201	interleukin 1 beta	Homo sapiens	52-60
24086293-5	2013	Cultures treated with high glucose and BSO displayed a significantly lower growth rate, and cultures treated with IL1B showed a trend towards a higher growth rate, compared to the control [Glucose:0.14 PD/day, p&lt;0.001, BSO: 0.11 PD/day, p = 0.006 and IL1B: 0.19 PD/day, p = 0.093 vs. CONTROL: 0.16 PD/day].	Glucose	189-196	interleukin 1 beta	Homo sapiens	114-118
24073294-11	2013	In vivo, U0126 significantly increased cell apoptosis and decreased cell proliferation in the intestine, increased intestinal permeability, intestinal and lung neutrophil infiltration, and injury, as well as systemic pro-inflammatory cytokines, TNF-alpha, IL-6 and IL-1beta.	U 0126	9-14	interleukin 1 beta	Homo sapiens	265-273
23864609-9	2013	IL-1beta and TNF-alpha enhanced the production of PGE2.	Dinoprostone	50-54	interleukin 1 beta	Homo sapiens	0-8
23886446-0	2013	Interleukin-1beta reduces galactose transport in intestinal epithelial cells in a NF-kB and protein kinase C-dependent manner.	Galactose	26-35	interleukin 1 beta	Homo sapiens	0-17
24147214-3	2013	Previous evidence in a Japanese population revealed that the homozygotes for allele T at position -511 of the interleukin (IL)-1beta gene promoter region (IL-1beta-511 T/T) confers susceptibility to the development of HS.	Hydrogen	218-220	interleukin 1 beta	Homo sapiens	110-132
24147214-3	2013	Previous evidence in a Japanese population revealed that the homozygotes for allele T at position -511 of the interleukin (IL)-1beta gene promoter region (IL-1beta-511 T/T) confers susceptibility to the development of HS.	Hydrogen	218-220	interleukin 1 beta	Homo sapiens	155-163
23886446-10	2013	In summary, the direct addition of IL-1beta to intestinal epithelia inhibits d-galactose transport by a possible reduction in the SGLT1 activity.	Galactose	77-88	interleukin 1 beta	Homo sapiens	35-43
23908180-8	2013	Significantly higher levels of IL-1beta and IL-23 were detected in the supernatants of monocytes stimulated with LPS or PGN.	pgn	120-123	interleukin 1 beta	Homo sapiens	31-39
23590581-4	2013	RESULTS: MgSO4 exposure increased intracellular magnesium levels, reducing the frequency of THP-1 cells producing IL-1beta, IL-8, and TNF-alpha following LPS stimulation.	Magnesium Sulfate	9-14	interleukin 1 beta	Homo sapiens	114-122
23611517-6	2013	Serum creatinine at time of diagnosis had significant correlation with proteinuria (p = 0.02), urinary levels of IL-1beta (p = 0.03), IL-2 (p = 0.01) and MCP-1 (p = 0.03).	Creatinine	6-16	interleukin 1 beta	Homo sapiens	113-121
23475935-9	2013	NTBI levels were higher after transfusion (p&lt;0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p&lt;0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha.	ntbi	0-4	interleukin 1 beta	Homo sapiens	246-254
23475935-9	2013	NTBI levels were higher after transfusion (p&lt;0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p&lt;0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha.	ntbi	115-119	interleukin 1 beta	Homo sapiens	246-254
23774263-9	2013	These results suggest the potential for use of RA as an anti-sEPCR shedding reagent against PMA, TNF-alpha, IL-1beta and CLP-mediated EPCR shedding.	rosmarinic acid	47-49	interleukin 1 beta	Homo sapiens	108-116
23751319-6	2013	Compared with the LPS control group, APS (100 mug/mL) or SAPS (100 mug/mL) administration decreased the expression of TNF-alpha, IL-1beta and IL-8.	saps	57-61	interleukin 1 beta	Homo sapiens	129-137
23778262-8	2013	Specifically, FOXO1 knockdown significantly decreased IL-1beta-induced IL-6 and IL-8 expression; production and COX-2 expression and subsequent prostaglandin (PGE2 and PGF2alpha) release; and MMP-9 mRNA expression and activity.	Prostaglandins	144-157	interleukin 1 beta	Homo sapiens	54-62
23778262-8	2013	Specifically, FOXO1 knockdown significantly decreased IL-1beta-induced IL-6 and IL-8 expression; production and COX-2 expression and subsequent prostaglandin (PGE2 and PGF2alpha) release; and MMP-9 mRNA expression and activity.	Dinoprostone	159-163	interleukin 1 beta	Homo sapiens	54-62
23638885-6	2013	3,4,6-O-Bu3GlcNAc exposure decreased the expression of NFkappaB target genes relevant to OA by IL-1beta-stimulated chondrocytes after 24 h of exposure.	3,4,6-o-bu3glcnac	0-17	interleukin 1 beta	Homo sapiens	95-103
23797607-4	2013	The Fura-2 Ca2+ imaging revealed that IL-1beta increased intracellular Ca2+ concentration even after removal of extracellular Ca2+, which was blocked by an inhibitor of inositol 1,4,5-trisphosphate receptors, 2-aminoethoxydiphenyl borate (2-APB, 1 muM).	Fura-2	4-10	interleukin 1 beta	Homo sapiens	38-46
23797607-4	2013	The Fura-2 Ca2+ imaging revealed that IL-1beta increased intracellular Ca2+ concentration even after removal of extracellular Ca2+, which was blocked by an inhibitor of inositol 1,4,5-trisphosphate receptors, 2-aminoethoxydiphenyl borate (2-APB, 1 muM).	Inositol	169-177	interleukin 1 beta	Homo sapiens	38-46
23797607-4	2013	The Fura-2 Ca2+ imaging revealed that IL-1beta increased intracellular Ca2+ concentration even after removal of extracellular Ca2+, which was blocked by an inhibitor of inositol 1,4,5-trisphosphate receptors, 2-aminoethoxydiphenyl borate (2-APB, 1 muM).	2-aminoethoxydiphenyl borate	209-237	interleukin 1 beta	Homo sapiens	38-46
23797607-4	2013	The Fura-2 Ca2+ imaging revealed that IL-1beta increased intracellular Ca2+ concentration even after removal of extracellular Ca2+, which was blocked by an inhibitor of inositol 1,4,5-trisphosphate receptors, 2-aminoethoxydiphenyl borate (2-APB, 1 muM).	2-aminoethoxydiphenyl borate	239-244	interleukin 1 beta	Homo sapiens	38-46
23927563-5	2013	The ability of IL1beta to stimulate the expression of cyclooxygenase-2 (COX-2) and biosynthesis of the prostaglandin E2 (PGE2) in MDA-MB-231 cells were also determined.	Dinoprostone	121-125	interleukin 1 beta	Homo sapiens	15-22
23927563-8	2013	Furthermore, addition of the COX-2 inhibitor NS-398 prevented the stimulation of cancer cell invasion induced either by irradiated fibroblasts or IL1beta.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	45-51	interleukin 1 beta	Homo sapiens	146-153
22906565-4	2013	Anthocyanin consumption significantly decreased the levels of serum high sensitivity C-reactive protein (hsCRP) (-21.6% vs. -2.5%, P = 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1) (-12.3% vs. 0.4%, P = 0.005) and plasma IL-1beta (-12.8% vs. -1.3%, P = 0.019) compared to the placebo.	Anthocyanins	0-11	interleukin 1 beta	Homo sapiens	235-243
23927563-9	2013	We propose that the effect of IL1beta on the invasiveness of the MDA-MB-231 cells involves elevation of matrix metalloproteinase-9 (MMP-9) production, induction of COX-2 expression and PGE2 biosynthesis.	Dinoprostone	185-189	interleukin 1 beta	Homo sapiens	30-37
23947692-2	2013	On immune system, imatinib has antiproliferative activity and immunomodulatory effects in lymphocytes, macrophages, mast cells and dendritic cells with abrogating multiple signal transduction pathways involved in pathogenesis of autoimmune diseases e.g. inhibiting IFN-gamma, TNF-alpha, IL-1beta and IL-17 pro-inflammatory cytokines and MMPs secretion.	Imatinib Mesylate	18-26	interleukin 1 beta	Homo sapiens	287-295
23638885-7	2013	The capacity of 3,4,6-O-Bu3GlcNAc to stimulate extracellular matrix (ECM) accumulation by IL-1beta-stimulated chondrocytes was evaluated in vitro utilizing a three-dimensional hydrogel culturing system.	3,4,6-o-bu3glcnac	16-33	interleukin 1 beta	Homo sapiens	90-98
23638885-11	2013	These findings demonstrate that a novel butanoylated GlcNAc derivative, 3,4,6-O-Bu3GlcNAc, has the potential to stimulate new tissue production and reduce inflammation in IL-1beta-induced chondrocytes with utility for OA and other forms of inflammatory arthritis.	Acetylglucosamine	53-59	interleukin 1 beta	Homo sapiens	171-179
23638885-11	2013	These findings demonstrate that a novel butanoylated GlcNAc derivative, 3,4,6-O-Bu3GlcNAc, has the potential to stimulate new tissue production and reduce inflammation in IL-1beta-induced chondrocytes with utility for OA and other forms of inflammatory arthritis.	3,4,6-o-bu3glcnac	72-89	interleukin 1 beta	Homo sapiens	171-179
23972849-4	2013	A series of topologically equivalent water-mediated beta-strand bridging interactions within the pseudosymmetric beta-trefoil fold of IL-1beta highlight the backbone water interactions that stabilize the secondary and tertiary structure of the protein.	Water	37-42	interleukin 1 beta	Homo sapiens	134-142
23971009-2	2013	Upon stimulation by various proinflammatory stimuli such as lipopolysaccharide (LPS), interleukin (IL)-1beta, and tumor necrosis factor (TNF)-alpha, PGE2 synthesis is upregulated by the expression of cyclooxygenases.	Dinoprostone	149-153	interleukin 1 beta	Homo sapiens	86-108
23972849-4	2013	A series of topologically equivalent water-mediated beta-strand bridging interactions within the pseudosymmetric beta-trefoil fold of IL-1beta highlight the backbone water interactions that stabilize the secondary and tertiary structure of the protein.	Water	166-171	interleukin 1 beta	Homo sapiens	134-142
23977231-6	2013	Inhibition studies using antisense RNA and the pharmacological agent BAY-117082 confirmed the involvement of NF-kappaB in IL-6, IL-8, and IL-1beta secretion.	3-(4-methylphenylsulfonyl)-2-propenenitrile	69-79	interleukin 1 beta	Homo sapiens	138-146
24062615-7	2013	RESULTS: We have demonstrated that budesonide concentration-dependently (10(-10)-10(-7) M) inhibited IL-6, IL-8, MMP-1, and MMP-3 release by HFL-1 cells in response to IL-1beta plus TNF-alpha.	Budesonide	35-45	interleukin 1 beta	Homo sapiens	168-176
23977231-7	2013	S100A8- and S100A9-mediated activation of NF-kappaB, the NLR family, pyrin domain-containing 3 (NLRP3) protein, and pro-IL-1beta expression was dependent on the generation of reactive oxygen species.	Reactive Oxygen Species	175-198	interleukin 1 beta	Homo sapiens	116-128
23320930-7	2013	On the other hand, the relative gene expressions of E-cadherin and IL-1beta in epithelial cells of the 3D culture under decidualization conditions significantly differed from those in epithelial cells grown over the fibrin-agarose gel matrix without stromal cells, pointing to regulation of epithelial cells by the stroma.	Sepharose	223-230	interleukin 1 beta	Homo sapiens	67-75
24575330-5	2013	After polarization of MBP-primed Th1 cells to Th2 by gemfibrozil and other drugs, we observed that MBP-primed Th2 cells dose dependently inhibited the production of interleukin-1beta (IL-1beta) and nitric oxide (NO) in LPS-stimulated microglia via cell-to-cell contact.	Gemfibrozil	53-64	interleukin 1 beta	Homo sapiens	165-182
23904475-4	2013	We now report that, in response to IL-1beta, the p65 subunit of NF-kappaB is dimethylated on arginine 30 (R30) by protein-arginine methyltransferase 5 (PRMT5).	Arginine	93-101	interleukin 1 beta	Homo sapiens	35-43
23991114-11	2013	Cytokines in supernatants of macrophages exposed to BAK revealed an increased release of CCL1, CCL4/MIP-1beta, TNF-alpha, soluble CD54/ICAM-1 and IL-1beta.	Benzalkonium Compounds	52-55	interleukin 1 beta	Homo sapiens	146-154
24575330-5	2013	After polarization of MBP-primed Th1 cells to Th2 by gemfibrozil and other drugs, we observed that MBP-primed Th2 cells dose dependently inhibited the production of interleukin-1beta (IL-1beta) and nitric oxide (NO) in LPS-stimulated microglia via cell-to-cell contact.	Nitric Oxide	198-210	interleukin 1 beta	Homo sapiens	184-192
24575330-5	2013	After polarization of MBP-primed Th1 cells to Th2 by gemfibrozil and other drugs, we observed that MBP-primed Th2 cells dose dependently inhibited the production of interleukin-1beta (IL-1beta) and nitric oxide (NO) in LPS-stimulated microglia via cell-to-cell contact.	Nitric Oxide	198-210	interleukin 1 beta	Homo sapiens	165-182
23927290-8	2013	The method is validated by predicting the number and location of water molecules in 5 pockets in the protein Interleukin-1beta for which experimental water occupancy data are available.	Water	65-70	interleukin 1 beta	Homo sapiens	109-126
23915129-11	2013	In vitro studies demonstrated that MitoQ decreases IL-1 beta and IL-18 production in human THP-1 cells.	mitoquinone	35-40	interleukin 1 beta	Homo sapiens	51-60
23798679-6	2013	In addition, the extracellular overproduction of metabolites such as uric acid and cholesterol crystals acts as a signal sensed by NLRP3, leading to the production of IL-1beta.	Uric Acid	69-78	interleukin 1 beta	Homo sapiens	167-175
23798679-6	2013	In addition, the extracellular overproduction of metabolites such as uric acid and cholesterol crystals acts as a signal sensed by NLRP3, leading to the production of IL-1beta.	Cholesterol	83-94	interleukin 1 beta	Homo sapiens	167-175
23927290-8	2013	The method is validated by predicting the number and location of water molecules in 5 pockets in the protein Interleukin-1beta for which experimental water occupancy data are available.	Water	150-155	interleukin 1 beta	Homo sapiens	109-126
23666803-0	2013	Sphingosine 1-phosphate counteracts the effects of interleukin-1beta in human chondrocytes.	sphingosine 1-phosphate	0-23	interleukin 1 beta	Homo sapiens	51-68
23322405-8	2013	The present data show that anti-IL-1beta biological treatment is actually a therapeutic option for FMF patients unresponsive or intolerant to colchicine or in FMF patients with concomitant vasculitis.	Colchicine	142-152	interleukin 1 beta	Homo sapiens	32-40
23607494-8	2013	Furthermore, poly(I:C) and proinflammatory cytokines [(IL-1beta, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha] induced IL-32 expression strongly in cultured BECs, accompanying the constant expression of TLR-3 and caspase 1.	poly	13-17	interleukin 1 beta	Homo sapiens	55-63
23514733-0	2013	Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1beta antibody, in patients with type 2 diabetes.	LY2189102	101-110	interleukin 1 beta	Homo sapiens	127-135
23607494-8	2013	Furthermore, poly(I:C) and proinflammatory cytokines [(IL-1beta, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha] induced IL-32 expression strongly in cultured BECs, accompanying the constant expression of TLR-3 and caspase 1.	Iodine	18-19	interleukin 1 beta	Homo sapiens	55-63
23607494-8	2013	Furthermore, poly(I:C) and proinflammatory cytokines [(IL-1beta, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha] induced IL-32 expression strongly in cultured BECs, accompanying the constant expression of TLR-3 and caspase 1.	Carbon	20-21	interleukin 1 beta	Homo sapiens	55-63
23559389-4	2013	Significantly high IL-1beta, IL-6, TNF-alpha, CXCL10, and CCL2 in MC + HCV vs healthy controls were confirmed.	Methylcholanthrene	66-68	interleukin 1 beta	Homo sapiens	19-27
23514733-3	2013	This study aimed to determine the efficacy, safety, and tolerability of LY2189102, a neutralizing IL-1beta antibody, in T2DM patients.	LY2189102	72-81	interleukin 1 beta	Homo sapiens	98-106
23673285-5	2013	IL-1beta at 2.5ng/mL induced an early (0.5-3h) and a late (12h) elevation of intracellular PAF levels (2-fold).	Tritium	43-45	interleukin 1 beta	Homo sapiens	0-8
23664858-9	2013	IL-1beta-induced IkappaBalpha phosphorylation and degradation decreased in the presence of pirfenidone and led to decreased nuclear translocation and DNA binding of the active NF-kappaB complex.	pirfenidone	91-102	interleukin 1 beta	Homo sapiens	0-8
23664858-0	2013	Pirfenidone attenuates IL-1beta-induced COX-2 and PGE2 production in orbital fibroblasts through suppression of NF-kappaB activity.	pirfenidone	0-11	interleukin 1 beta	Homo sapiens	23-31
23664858-11	2013	Our results suggest that pirfenidone attenuates the IL-1beta-induced PGE2/COX-2 production in TAO orbital fibroblasts, which is related with suppression of the NF-kappaB activation.	pirfenidone	25-36	interleukin 1 beta	Homo sapiens	52-60
23664858-0	2013	Pirfenidone attenuates IL-1beta-induced COX-2 and PGE2 production in orbital fibroblasts through suppression of NF-kappaB activity.	Dinoprostone	50-54	interleukin 1 beta	Homo sapiens	23-31
23727178-4	2013	In blood, ZEN increases the respiratory burst of monocytes and the inflammatory cytokine (TNF alpha, IL-1 beta, IFN gamma) synthesis, while in liver, ZEN decreases the synthesis of all inflammatory cytokines investigated.	Zearalenone	10-13	interleukin 1 beta	Homo sapiens	101-110
23664858-11	2013	Our results suggest that pirfenidone attenuates the IL-1beta-induced PGE2/COX-2 production in TAO orbital fibroblasts, which is related with suppression of the NF-kappaB activation.	Dinoprostone	69-73	interleukin 1 beta	Homo sapiens	52-60
23664858-3	2013	The level of PGE2 in orbital fibroblasts treated with IL-1beta in the presence or absence of pirfenidone was measured using an enzyme-linked immunosorbent assay.	Dinoprostone	13-17	interleukin 1 beta	Homo sapiens	54-62
23664858-4	2013	The effect of pirfenidone on IL-1beta-induced COX-2 expression in orbital fibroblasts from patients with TAO was evaluated by reverse transcription-polymerase chain reaction (PCR) and quantitative real-time PCR analyses, and verified by Western blot.	pirfenidone	14-25	interleukin 1 beta	Homo sapiens	29-37
23689555-7	2013	Post-treatment with PPs also more efficiently than pretreatment prevented UV-induced overexpression of IL-1 beta, IL-6 and COX2 mRNAs.	pps	20-23	interleukin 1 beta	Homo sapiens	103-112
23664858-7	2013	Pirfenidone significantly attenuated IL-1beta-induced PGE2 release in both TAO and non-TAO cells.	pirfenidone	0-11	interleukin 1 beta	Homo sapiens	37-45
23664858-7	2013	Pirfenidone significantly attenuated IL-1beta-induced PGE2 release in both TAO and non-TAO cells.	Dinoprostone	54-58	interleukin 1 beta	Homo sapiens	37-45
23664858-8	2013	IL-1beta-induced COX-2 mRNA and protein expression decreased significantly following co-treatment with pirfenidone.	pirfenidone	103-114	interleukin 1 beta	Homo sapiens	0-8
23673400-11	2013	Of these, pseudouridine increased monocyte expression of TNFalpha and IL1beta versus control (p &lt; 0.05).	Pseudouridine	10-23	interleukin 1 beta	Homo sapiens	70-77
23788611-6	2013	Conversely, IL-1beta strongly stimulated PGE2 protein levels in gingival fibroblasts, and chitosan inhibited this response at 50 microg/mL.	Dinoprostone	41-45	interleukin 1 beta	Homo sapiens	12-20
23788611-7	2013	IL-1beta-stimulated PGE2 production was dependent on the JNK pathway, and chitosan strongly inhibited this response.	Dinoprostone	20-24	interleukin 1 beta	Homo sapiens	0-8
23788611-8	2013	IL-1beta stimulated NF-kappaB activation, another signaling pathway involved in PGE2 production.	Dinoprostone	80-84	interleukin 1 beta	Homo sapiens	0-8
23904362-6	2013	The results showed that Sal significantly decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at both mRNA and protein levels in THP-1-derived macrophages, and the effect was dose-depedent.	rhodioloside	24-27	interleukin 1 beta	Homo sapiens	135-152
23488678-0	2013	Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cells.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	74-92
23488678-5	2013	When exposed to 10 ng/mL IL-1beta, various concentrations of melatonin resulted in significant reduction of ROS by 34.9% averagely.	Melatonin	61-70	interleukin 1 beta	Homo sapiens	25-33
23488678-5	2013	When exposed to 10 ng/mL IL-1beta, various concentrations of melatonin resulted in significant reduction of ROS by 34.9% averagely.	Reactive Oxygen Species	108-111	interleukin 1 beta	Homo sapiens	25-33
23488678-6	2013	Luzindole as a melatonin receptor antagonist reversed the anti-oxidant effect of melatonin in MSCs with co-exposure to IL-1beta.	luzindole	0-9	interleukin 1 beta	Homo sapiens	119-127
23488678-6	2013	Luzindole as a melatonin receptor antagonist reversed the anti-oxidant effect of melatonin in MSCs with co-exposure to IL-1beta.	Melatonin	15-24	interleukin 1 beta	Homo sapiens	119-127
24101387-1	2013	Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS).	Reactive Oxygen Species	0-23	interleukin 1 beta	Homo sapiens	209-227
24101387-1	2013	Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS).	Reactive Oxygen Species	0-23	interleukin 1 beta	Homo sapiens	229-237
24101387-1	2013	Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS).	Reactive Oxygen Species	25-28	interleukin 1 beta	Homo sapiens	209-227
24101387-1	2013	Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS).	Reactive Oxygen Species	25-28	interleukin 1 beta	Homo sapiens	229-237
24101387-1	2013	Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS).	Superoxides	58-82	interleukin 1 beta	Homo sapiens	209-227
24101387-1	2013	Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS).	Superoxides	58-82	interleukin 1 beta	Homo sapiens	229-237
24101387-1	2013	Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS).	Hydroxyl Radical	86-102	interleukin 1 beta	Homo sapiens	209-227
24101387-1	2013	Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS).	Hydroxyl Radical	86-102	interleukin 1 beta	Homo sapiens	229-237
23030238-8	2013	LPS-induced IL-6, IL-1beta, and BLC expression was attenuated in human monocytes treated with estrogen and progesterone.	Progesterone	107-119	interleukin 1 beta	Homo sapiens	18-26
23488678-9	2013	After exposed to IL-1beta for 21 days, 1 mum melatonin treatment significantly increased the levels of type I collagen, ALP, and osteocalcin, and 100 mum melatonin treatment yielded the highest level of osteopontin.	Melatonin	45-54	interleukin 1 beta	Homo sapiens	17-25
23488678-9	2013	After exposed to IL-1beta for 21 days, 1 mum melatonin treatment significantly increased the levels of type I collagen, ALP, and osteocalcin, and 100 mum melatonin treatment yielded the highest level of osteopontin.	Melatonin	154-163	interleukin 1 beta	Homo sapiens	17-25
23488678-10	2013	Our study demonstrated that melatonin maintained MSC survival and promoted osteogenic differentiation in inflammatory environment induced by IL-1beta, suggesting melatonin treatment could be a promising method for bone regenerative engineering in future studies.	Melatonin	28-37	interleukin 1 beta	Homo sapiens	141-149
23488678-10	2013	Our study demonstrated that melatonin maintained MSC survival and promoted osteogenic differentiation in inflammatory environment induced by IL-1beta, suggesting melatonin treatment could be a promising method for bone regenerative engineering in future studies.	Melatonin	162-171	interleukin 1 beta	Homo sapiens	141-149
23904362-6	2013	The results showed that Sal significantly decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at both mRNA and protein levels in THP-1-derived macrophages, and the effect was dose-depedent.	rhodioloside	24-27	interleukin 1 beta	Homo sapiens	154-162
23904362-8	2013	The findings suggested that Sal can suppress the activation of LPS-stimulated PMA-differetiated THP-1 cells, as evidenced by the decreased expression of iNOS, COX2, IL-1beta, IL-6 and TNF-alpha, and the mechanism involves the inhibition of NF-kappaB activation and the phosphorylation of the MAPK signal pathway.	rhodioloside	28-31	interleukin 1 beta	Homo sapiens	165-173
23657597-3	2013	TNF-alpha and IL-1beta enhanced the alkaline phosphatase (ALP) activity and alizarin red S staining in cultured human periosteal-derived cells.	Alizarin Red S	76-90	interleukin 1 beta	Homo sapiens	14-22
24244812-3	2013	Treatment with SB-657510 significantly inhibited UII-induced expression of IL-1beta, IL-6, and VCAM-1 in EA.hy926 cells.	SB 657510	15-24	interleukin 1 beta	Homo sapiens	75-83
24303127-5	2013	Tulobuterol reduced the RV14 titers and RNA levels; the concentrations of cytokines, including interleukin (IL)-1beta, IL-6, and IL-8, in the supernatants; and susceptibility to RV14 infection.	tulobuterol	0-11	interleukin 1 beta	Homo sapiens	95-117
23314958-8	2013	Transfection of primary amnion cells with apelin siRNA was associated with significantly increased interleukin (IL)-1beta-induced IL-6 and IL-8 release and cyclooxygenase-2 messenger RNA (mRNA) expression and resultant prostaglandin E2 and prostaglandin F2alpha release.	Dinoprost	240-261	interleukin 1 beta	Homo sapiens	99-121
23470228-3	2013	We have decorated silk protein with sulfonated moieties through diazonium coupling reactions to noncovalently immobilize pro-inflammatory cytokines interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) in such a biomimetic manner.	diazynium	64-73	interleukin 1 beta	Homo sapiens	148-166
23470228-3	2013	We have decorated silk protein with sulfonated moieties through diazonium coupling reactions to noncovalently immobilize pro-inflammatory cytokines interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) in such a biomimetic manner.	diazynium	64-73	interleukin 1 beta	Homo sapiens	168-176
23680158-11	2013	In addition, when the production of IL-1beta and TNFalpha by lipopolysaccharide (LPS) or hemozoin (malaria pigment) stimulated human THP-1 monocytes was assayed, it was found that the extract of Canthium henriquesianum induced a dose-dependent inhibition of IL-1beta, but not of TNFalpha production, thus confirming its traditional use as antipyretic.	canthium henriquesianum	195-218	interleukin 1 beta	Homo sapiens	36-44
23680158-11	2013	In addition, when the production of IL-1beta and TNFalpha by lipopolysaccharide (LPS) or hemozoin (malaria pigment) stimulated human THP-1 monocytes was assayed, it was found that the extract of Canthium henriquesianum induced a dose-dependent inhibition of IL-1beta, but not of TNFalpha production, thus confirming its traditional use as antipyretic.	canthium henriquesianum	195-218	interleukin 1 beta	Homo sapiens	258-266
23874646-9	2013	In contrast, IL-1beta production by 20 nm LxB was augmented by NAC and in BMDM deficient in thioredoxin-binding protein-2 (TBP-2), a negative regulator of the ROS scavenger thioredoxin.	Reactive Oxygen Species	159-162	interleukin 1 beta	Homo sapiens	13-21
23760261-0	2013	Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1beta production following Toll-like receptor 2 stimulation in THP-1 monocytes.	Flavonoids	39-48	interleukin 1 beta	Homo sapiens	79-87
23760261-3	2013	We found that the flavonols selectively co-stimulated IL-1beta secretion but had no impact on the secretion of IL-6.	Flavonols	18-27	interleukin 1 beta	Homo sapiens	54-62
23760261-6	2013	In contrast, the methylated flavonols enhanced IL-1beta gene expression through transcriptional regulation, involving mechanisms that operate downstream of the initial NF-kappaB and STAT1 activation events.	Flavonols	28-37	interleukin 1 beta	Homo sapiens	47-55
23578992-3	2013	GTN and SNP produced a delayed meningeal inflammation, as showed by the upregulation of interleukin (IL)-1beta and inducible NO synthase (iNOS), and a prolonged cold allodynia and heat hyperalgesia with a time-course consistent with NO-induced migraine attacks.	Nitroglycerin	0-3	interleukin 1 beta	Homo sapiens	88-110
23874646-1	2013	Macrophages (Mphi) are well documented to produce IL-1beta through various signaling pathways in response to small particles such as silica, asbestos and urea crystals, in the presence of lipopolysaccharide (LPS).	Silicon Dioxide	133-139	interleukin 1 beta	Homo sapiens	50-58
23874646-1	2013	Macrophages (Mphi) are well documented to produce IL-1beta through various signaling pathways in response to small particles such as silica, asbestos and urea crystals, in the presence of lipopolysaccharide (LPS).	Urea	154-158	interleukin 1 beta	Homo sapiens	50-58
23874646-8	2013	The response by 1,000 nm LxB relied on a robust production of reactive oxygen species (ROS), since IL-1beta production was remarkably reduced by ROS inhibitors such as diphenylene iodonium (DPI) and N-acetylcysteine (NAC).	Reactive Oxygen Species	62-85	interleukin 1 beta	Homo sapiens	99-107
23874646-8	2013	The response by 1,000 nm LxB relied on a robust production of reactive oxygen species (ROS), since IL-1beta production was remarkably reduced by ROS inhibitors such as diphenylene iodonium (DPI) and N-acetylcysteine (NAC).	Reactive Oxygen Species	87-90	interleukin 1 beta	Homo sapiens	99-107
23889808-7	2013	RESULTS: The hexadecylamide derivative of HA had significantly better amelioration of IL-1beta-induced gene expression of key matrix degrading enzymes (MMP1, MMP13, ADAMTS5), and inflammatory mediators (IL6, PTGS2) by human OA chondrocytes and synovial fibroblasts.	hexadecylamide	13-27	interleukin 1 beta	Homo sapiens	86-94
23889808-9	2013	The reduction in MMP13 mRNA by the amide derivative of HA was mirrored in reduced MMP-13 protein and enzyme activity in IL-1beta-stimulated chondrocytes.	Amides	35-40	interleukin 1 beta	Homo sapiens	120-128
23883591-8	2013	There was strong parallelism in the actions of CNP on cGMP induction resulting in enhanced GAG synthesis and reduction of NO and PGE2 release induced by IL-1beta.	Cyclic GMP	54-58	interleukin 1 beta	Homo sapiens	153-161
23883591-8	2013	There was strong parallelism in the actions of CNP on cGMP induction resulting in enhanced GAG synthesis and reduction of NO and PGE2 release induced by IL-1beta.	Dinoprostone	129-133	interleukin 1 beta	Homo sapiens	153-161
23883591-15	2013	The loading-induced CNP/Npr2/cGMP signalling route mediates anabolic events and prevents catabolic activities induced by IL-1beta.	Cyclic GMP	29-33	interleukin 1 beta	Homo sapiens	121-129
23839215-4	2013	Treating monocytes with the caspase-1 inhibitor Ac-YVAD-CMK reduced IL-1beta release, suggesting a role for the inflammasome in T. gondii-induced IL-1beta production.	ac-yvad	48-55	interleukin 1 beta	Homo sapiens	68-76
23839215-4	2013	Treating monocytes with the caspase-1 inhibitor Ac-YVAD-CMK reduced IL-1beta release, suggesting a role for the inflammasome in T. gondii-induced IL-1beta production.	ac-yvad	48-55	interleukin 1 beta	Homo sapiens	146-154
23880858-5	2013	Our results showed that radiation significantly increased IL-1beta mRNA and protein expression and that pretreatment with resveratrol, a Sirt1 activator, inhibited the radiation-induced IL-1beta expression in a concentration-dependent manner, whereas the knockdown or inhibition of Sirt1 by nicotinamide significantly enhanced radiation-induced IL-1beta expression.	Resveratrol	122-133	interleukin 1 beta	Homo sapiens	58-66
23880858-5	2013	Our results showed that radiation significantly increased IL-1beta mRNA and protein expression and that pretreatment with resveratrol, a Sirt1 activator, inhibited the radiation-induced IL-1beta expression in a concentration-dependent manner, whereas the knockdown or inhibition of Sirt1 by nicotinamide significantly enhanced radiation-induced IL-1beta expression.	Resveratrol	122-133	interleukin 1 beta	Homo sapiens	186-194
23874646-8	2013	The response by 1,000 nm LxB relied on a robust production of reactive oxygen species (ROS), since IL-1beta production was remarkably reduced by ROS inhibitors such as diphenylene iodonium (DPI) and N-acetylcysteine (NAC).	Reactive Oxygen Species	145-148	interleukin 1 beta	Homo sapiens	99-107
23874646-8	2013	The response by 1,000 nm LxB relied on a robust production of reactive oxygen species (ROS), since IL-1beta production was remarkably reduced by ROS inhibitors such as diphenylene iodonium (DPI) and N-acetylcysteine (NAC).	diphenyleneiodonium	168-188	interleukin 1 beta	Homo sapiens	99-107
23874646-8	2013	The response by 1,000 nm LxB relied on a robust production of reactive oxygen species (ROS), since IL-1beta production was remarkably reduced by ROS inhibitors such as diphenylene iodonium (DPI) and N-acetylcysteine (NAC).	diphenyleneiodonium	190-193	interleukin 1 beta	Homo sapiens	99-107
23526221-8	2013	We observed significant up-regulation of IL-1beta and IL-6 in bronchoalveolar lavage fluid (BALF) in bleomycin-induced lung fibrosis in vivo.	Bleomycin	101-110	interleukin 1 beta	Homo sapiens	41-49
23874646-8	2013	The response by 1,000 nm LxB relied on a robust production of reactive oxygen species (ROS), since IL-1beta production was remarkably reduced by ROS inhibitors such as diphenylene iodonium (DPI) and N-acetylcysteine (NAC).	Acetylcysteine	199-215	interleukin 1 beta	Homo sapiens	99-107
23874646-8	2013	The response by 1,000 nm LxB relied on a robust production of reactive oxygen species (ROS), since IL-1beta production was remarkably reduced by ROS inhibitors such as diphenylene iodonium (DPI) and N-acetylcysteine (NAC).	Acetylcysteine	217-220	interleukin 1 beta	Homo sapiens	99-107
23874646-9	2013	In contrast, IL-1beta production by 20 nm LxB was augmented by NAC and in BMDM deficient in thioredoxin-binding protein-2 (TBP-2), a negative regulator of the ROS scavenger thioredoxin.	Acetylcysteine	63-66	interleukin 1 beta	Homo sapiens	13-21
23880858-5	2013	Our results showed that radiation significantly increased IL-1beta mRNA and protein expression and that pretreatment with resveratrol, a Sirt1 activator, inhibited the radiation-induced IL-1beta expression in a concentration-dependent manner, whereas the knockdown or inhibition of Sirt1 by nicotinamide significantly enhanced radiation-induced IL-1beta expression.	Resveratrol	122-133	interleukin 1 beta	Homo sapiens	186-194
23526221-9	2013	Importantly, primary fibrotic ATII cells isolated from lungs subjected to bleomycin secreted enhanced IL-1beta and IL-6 in vitro.	Bleomycin	74-83	interleukin 1 beta	Homo sapiens	102-110
23604718-4	2013	We found that SsnB dose-dependently attenuated the LPS-induced expression of interleukin (IL)-1beta and monocyte chemoattractant protein 1 both at the transcription and translation levels in HUVEC.	sparstolonin B	14-18	interleukin 1 beta	Homo sapiens	77-99
24036412-8	2013	The increasing secretion of IL-1beta, IL-6 and TNF-alpha induced by LPS could also be attenuated by the fosinoprilat treatment.	fosinoprilat	104-116	interleukin 1 beta	Homo sapiens	28-36
23624272-0	2013	The tellurium redox immunomodulating compound AS101 inhibits IL-1beta-activated inflammation in the human retinal pigment epithelium.	ammonium trichloro(dioxoethylene-O,O'-)tellurate	46-51	interleukin 1 beta	Homo sapiens	61-69
23628225-6	2013	The BALF concentrations of IL-1beta; IL-8; interferon-gamma-induced protein 10; regulated upon activation, normal T-cell expressed and secreted; neutrophil elastase; and pepsin were higher in patients with BOS (p &lt; 0.05).	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	206-209	interleukin 1 beta	Homo sapiens	27-35
22901987-3	2013	The main finding was that "in vitro" exposure to p,p"-DDE enhanced the expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) at the protein level in PBMCs.	Dichlorodiphenyl Dichloroethylene	49-57	interleukin 1 beta	Homo sapiens	123-131
23625868-7	2013	Stimulation of human astrocytes with ATP resulted in activation of the NLRP2 inflammasome leading to the processing of inflammatory caspase-1 and interleukin-1beta (IL-1beta).	Adenosine Triphosphate	37-40	interleukin 1 beta	Homo sapiens	146-163
23625868-7	2013	Stimulation of human astrocytes with ATP resulted in activation of the NLRP2 inflammasome leading to the processing of inflammatory caspase-1 and interleukin-1beta (IL-1beta).	Adenosine Triphosphate	37-40	interleukin 1 beta	Homo sapiens	165-173
23406266-8	2013	Induction of HO-1 by CoPP (cobalt protoporphyrin IX) reversed these IL-1beta actions.	cobaltiprotoporphyrin	21-25	interleukin 1 beta	Homo sapiens	68-76
23406266-8	2013	Induction of HO-1 by CoPP (cobalt protoporphyrin IX) reversed these IL-1beta actions.	cobaltiprotoporphyrin	27-51	interleukin 1 beta	Homo sapiens	68-76
23633206-8	2013	RESULTS: Orbital fibroblasts treated with IL-1beta exhibit greater inductions of IL-1alpha, IL-1beta, and prostaglandin endoperoxide H synthase-2 transcripts than do fibrocytes.	Prostaglandins	106-119	interleukin 1 beta	Homo sapiens	42-50
23678036-13	2013	The stimulatory effects of PGF2alpha were enhanced in the presence of IL-1beta, which reversed the inhibitory effect of PGF2alpha on PTGFR.	Dinoprost	27-36	interleukin 1 beta	Homo sapiens	70-78
23678036-13	2013	The stimulatory effects of PGF2alpha were enhanced in the presence of IL-1beta, which reversed the inhibitory effect of PGF2alpha on PTGFR.	Dinoprost	120-129	interleukin 1 beta	Homo sapiens	70-78
23567618-6	2013	The nuclear factor-kappaB (NF-kappaB) inhibitor dimethylfumarate inhibited TNF-alpha- and IL-1beta-induced IL-33 production as well as nuclear translocation of p50 and p65 NF-kappaB subunits in these cells.	Dimethyl Fumarate	48-64	interleukin 1 beta	Homo sapiens	90-98
23567618-7	2013	Mitogen-activated protein/extracellular signal-regulated kinase inhibitor U0126 abrogated TNF-alpha-, IFN-gamma-, and IL-1beta-induced and Janus-activated kinase inhibitor I reduced IFN-gamma-induced IL-33 production.	U 0126	74-79	interleukin 1 beta	Homo sapiens	118-126
23331485-6	2013	A COX inhibitor (indomethacin or celecoxib) was added to the IL-1beta-stimulated cells in culture.	Indomethacin	17-29	interleukin 1 beta	Homo sapiens	61-69
23331485-6	2013	A COX inhibitor (indomethacin or celecoxib) was added to the IL-1beta-stimulated cells in culture.	Celecoxib	33-42	interleukin 1 beta	Homo sapiens	61-69
23475986-7	2013	In myometrial cells, all treatments attenuated IL-1beta-induced COX-2 expression, release of PGE2 and PGF2alpha and expression and activity of MMP-9.	Dinoprostone	93-97	interleukin 1 beta	Homo sapiens	47-55
23475986-7	2013	In myometrial cells, all treatments attenuated IL-1beta-induced COX-2 expression, release of PGE2 and PGF2alpha and expression and activity of MMP-9.	Dinoprost	102-111	interleukin 1 beta	Homo sapiens	47-55
23475986-8	2013	Although naringenin significantly attenuated IL-1beta-induced IL-6 and IL-8 mRNA expression and release, there was no effect of curcumin and apigenin.	naringenin	9-19	interleukin 1 beta	Homo sapiens	45-53
23239618-4	2013	Furthermore, macrophages cells cultured onto Chi-AT immobilized titanium substrates demonstrated significantly lower (p &lt; 0.01) production levels of nitric oxide, acid phosphatase, reactive oxygen species, pro-inflammatory cytokines of tumor necrosis factor alpha, and interleukin-1 beta than those of controls.	chi-at	45-51	interleukin 1 beta	Homo sapiens	272-290
23328087-7	2013	The other member of the TET family with known roles in stem cell regulation, TET2, is also regulated in THP-1 cells following the inflammatory stimulus and may also participate in IL-1beta regulation, according to our observations.	tetramethylenedisulfotetramine	24-27	interleukin 1 beta	Homo sapiens	180-188
23791132-8	2013	Atorvastatin reduced IL-1b (p=0.01), IL-6 (p=0.03) and P-selectin (p=0.002) in controls.	Atorvastatin	0-12	interleukin 1 beta	Homo sapiens	21-26
23617551-10	2013	Inhaled budesonide significantly reduced LPS-induced IL-1beta, IL-6, IL-8 and TNF-alpha secretion, while inhaled formoterol had no such effect; however when combined, the inhibitory effect of budesonide was significantly increased by formoterol.	Budesonide	8-18	interleukin 1 beta	Homo sapiens	53-61
23809162-2	2013	Here we show that stimulation of macrophages with omega-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1beta secretion.	Fatty Acids, Omega-3	50-61	interleukin 1 beta	Homo sapiens	246-254
23809162-2	2013	Here we show that stimulation of macrophages with omega-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1beta secretion.	Eicosapentaenoic Acid	73-94	interleukin 1 beta	Homo sapiens	246-254
23809162-2	2013	Here we show that stimulation of macrophages with omega-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1beta secretion.	Eicosapentaenoic Acid	96-99	interleukin 1 beta	Homo sapiens	246-254
23809162-2	2013	Here we show that stimulation of macrophages with omega-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1beta secretion.	Docosahexaenoic Acids	102-122	interleukin 1 beta	Homo sapiens	246-254
23840534-8	2013	Inhibition of caspase-1 in human lung tissue led to a significant reduction of IL-1beta and IL-18 levels (IL-1beta: NTHi 24 h 17423+-3198pg/ml vs. NTHi+Z-YVAD-FMK 6961+-1751pg/ml, p&lt;0.01).	nthi	116-120	interleukin 1 beta	Homo sapiens	106-114
23722388-8	2013	Further, 13-cis RA also reduced the phosphorylation of Akt and increased the generation of interleukin-1beta and matrix metallopeptidase 9.	Radium	16-18	interleukin 1 beta	Homo sapiens	91-108
23840483-1	2013	Interleukin-1beta (IL-1beta) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis.	Reactive Oxygen Species	57-80	interleukin 1 beta	Homo sapiens	0-17
23840483-3	2013	We confirmed that in human C-20/A4 chondrocytes the NADPH oxidase Nox4 is the main source of ROS upon IL-1beta stimulation.	Reactive Oxygen Species	93-96	interleukin 1 beta	Homo sapiens	102-110
23328930-0	2013	Resveratrol inhibits TNF-alpha-induced IL-1beta, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	39-47
23328930-2	2013	The present study was designed to investigate the effects of resveratrol on TNF-alpha-induced inflammatory cytokines production of IL-1beta and MMP3 in Rheumatoid arthritis (RA) Fibroblast-like synoviocytes (FLS) and further to explore the role of PI3K/Akt signaling pathway by which resveratrol modulates those cytokines production.	Resveratrol	61-72	interleukin 1 beta	Homo sapiens	131-139
23328930-2	2013	The present study was designed to investigate the effects of resveratrol on TNF-alpha-induced inflammatory cytokines production of IL-1beta and MMP3 in Rheumatoid arthritis (RA) Fibroblast-like synoviocytes (FLS) and further to explore the role of PI3K/Akt signaling pathway by which resveratrol modulates those cytokines production.	Resveratrol	284-295	interleukin 1 beta	Homo sapiens	131-139
23328930-6	2013	Resveratrol inhibited both mRNA and proteins expressions of IL-1beta and MMP-3 on RA FLS in a dose-dependent manner.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	60-68
23328930-8	2013	Activation of PI3K/Akt signaling pathway exists in TNF-alpha-induced production of IL-1beta and MMP3 on RA FLS, which is hampered by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	interleukin 1 beta	Homo sapiens	83-91
23328930-10	2013	Resveratrol attenuates TNF-alpha-induced production of IL-1beta and MMP-3 via inhibition of PI3K-Akt signaling pathway in RA FLS, suggesting that resveratrol plays an anti-inflammatory role and might have beneficial effects in preventing and treating RA.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	55-63
23328930-10	2013	Resveratrol attenuates TNF-alpha-induced production of IL-1beta and MMP-3 via inhibition of PI3K-Akt signaling pathway in RA FLS, suggesting that resveratrol plays an anti-inflammatory role and might have beneficial effects in preventing and treating RA.	Resveratrol	146-157	interleukin 1 beta	Homo sapiens	55-63
23840483-1	2013	Interleukin-1beta (IL-1beta) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis.	Reactive Oxygen Species	57-80	interleukin 1 beta	Homo sapiens	19-27
23840483-1	2013	Interleukin-1beta (IL-1beta) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis.	Reactive Oxygen Species	82-85	interleukin 1 beta	Homo sapiens	0-17
23840483-1	2013	Interleukin-1beta (IL-1beta) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis.	Reactive Oxygen Species	82-85	interleukin 1 beta	Homo sapiens	19-27
23665321-0	2013	Arginase inhibition reduces interleukin-1beta-stimulated vascular smooth muscle cell proliferation by increasing nitric oxide synthase-dependent nitric oxide production.	nitric	113-119	interleukin 1 beta	Homo sapiens	28-45
23482646-5	2013	Chloroquine exerted a direct pH-dependent antifungal effect on Aspergillus fumigatus and Aspergillus nidulans; it increased the antifungal activity of PMNs from patients with CGD at a significantly lower concentration, compared with the concentration for PMNs from healthy individuals; and decreased the hyperinflammatory state of PBMCs from patients with CGD, as observed by decreased tumor necrosis factor alpha and interleukin 1beta release.	Chloroquine	0-11	interleukin 1 beta	Homo sapiens	418-435
23690471-5	2013	We found that sustained exposure of renal tubular cells to DHMEQ blocked TNF-alpha- and IL-1beta-induced TGF-beta-activated kinase 1 (TAK1) phosphorylation, a crucial event for NF-kappaB activation upstream of IkappaB kinase.	dehydroxymethylepoxyquinomicin	59-64	interleukin 1 beta	Homo sapiens	88-96
23665321-0	2013	Arginase inhibition reduces interleukin-1beta-stimulated vascular smooth muscle cell proliferation by increasing nitric oxide synthase-dependent nitric oxide production.	Nitric Oxide	113-125	interleukin 1 beta	Homo sapiens	28-45
23665321-5	2013	The specific iNOS inhibitor 1400W abolished IL-1beta-mediated NO production and further accentuated IL-1beta-stimulated cell proliferation.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	28-33	interleukin 1 beta	Homo sapiens	44-52
23665321-5	2013	The specific iNOS inhibitor 1400W abolished IL-1beta-mediated NO production and further accentuated IL-1beta-stimulated cell proliferation.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	28-33	interleukin 1 beta	Homo sapiens	100-108
23665321-6	2013	Incubation with NO donors GSNO and DETA/NO in the presence of IL-1beta abolished VSMCs proliferation and increased p21Waf1/Cip1 protein content.	S-Nitrosoglutathione	26-30	interleukin 1 beta	Homo sapiens	62-70
23665321-6	2013	Incubation with NO donors GSNO and DETA/NO in the presence of IL-1beta abolished VSMCs proliferation and increased p21Waf1/Cip1 protein content.	DEET	35-39	interleukin 1 beta	Homo sapiens	62-70
23665321-6	2013	Incubation with NO donors GSNO and DETA/NO in the presence of IL-1beta abolished VSMCs proliferation and increased p21Waf1/Cip1 protein content.	vsmcs	81-86	interleukin 1 beta	Homo sapiens	62-70
23665321-7	2013	Furthermore, incubation with the cGMP analogue 8-Br-cGMP prevented IL-1beta-induced VSMCs proliferation.	Cyclic GMP	33-37	interleukin 1 beta	Homo sapiens	67-75
23665321-7	2013	Furthermore, incubation with the cGMP analogue 8-Br-cGMP prevented IL-1beta-induced VSMCs proliferation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	47-56	interleukin 1 beta	Homo sapiens	67-75
23665321-8	2013	In conclusion, arginase inhibition augmented iNOS-dependent NO production that resulted in suppression of IL-1beta-induced VSMCs proliferation in a cGMP-dependent manner.	Cyclic GMP	148-152	interleukin 1 beta	Homo sapiens	106-114
23755232-11	2013	A549 cells incubated with TGF-beta1 for 72 h showed down-regulated COX-2 expression and low basal PGE2 secretion in response to IL-1beta.	Dinoprostone	98-102	interleukin 1 beta	Homo sapiens	128-136
23747241-3	2013	(2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1alpha, leading to activation of the proinflammatory cytokine IL-1beta.	Succinic Acid	53-62	interleukin 1 beta	Homo sapiens	226-234
23762324-0	2013	A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1beta production by human first trimester trophoblast.	Uric Acid	11-20	interleukin 1 beta	Homo sapiens	85-93
23762324-8	2013	Furthermore, aPL stimulated the production of uric acid in a TLR4-dependent manner; and inhibition of uric acid prevented aPL-induced IL-1beta production by the trophoblast.	Uric Acid	102-111	interleukin 1 beta	Homo sapiens	134-142
23762324-9	2013	These findings demonstrate that aPL, via TLR4 activation, induce a uric acid response in human trophoblast, which in turn activates the Nalp3/ASC inflammasome leading to IL-1beta processing and secretion.	Uric Acid	67-76	interleukin 1 beta	Homo sapiens	170-178
23755195-7	2013	Regarding the inflammation-related processes, the Zn(II) complexes significantly decreased IL-1beta production by a factor of 1.47-2.22 compared with the control (DMSO), but did not affect TNF-alpha and MMP-2 secretions.	Zinc	50-52	interleukin 1 beta	Homo sapiens	91-99
23583650-0	2013	Interleukin-1beta induces hyaluronan and CD44-dependent cell protrusions that facilitate fibroblast-monocyte binding.	Hyaluronic Acid	26-36	interleukin 1 beta	Homo sapiens	0-17
23564509-10	2013	RelB overexpression reduced IL-1beta-induced cyclooxygenase (Cox)-2, PGE2, and cytokine production, and RelB downregulation increased Cox-2 expression and PGE2 production.	Dinoprostone	69-73	interleukin 1 beta	Homo sapiens	28-36
23583650-3	2013	We previously demonstrated that fibroblasts stimulated with IL-1beta increased their generation of the polysaccharide hyaluronan (HA) and increased their expression of the HA synthase enzyme (HAS-2).	Polysaccharides	103-117	interleukin 1 beta	Homo sapiens	60-68
23564509-10	2013	RelB overexpression reduced IL-1beta-induced cyclooxygenase (Cox)-2, PGE2, and cytokine production, and RelB downregulation increased Cox-2 expression and PGE2 production.	Dinoprostone	155-159	interleukin 1 beta	Homo sapiens	28-36
23583650-3	2013	We previously demonstrated that fibroblasts stimulated with IL-1beta increased their generation of the polysaccharide hyaluronan (HA) and increased their expression of the HA synthase enzyme (HAS-2).	Hyaluronic Acid	118-128	interleukin 1 beta	Homo sapiens	60-68
23564509-12	2013	miR-146a overexpression ablated the effects of RelB downregulation on IL-1beta-induced Cox-2, PGE2, and IL-6 production, suggesting that RelB mediates IL-1beta-induced inflammatory mediator production in lung fibroblasts through miRNA-146a.	Dinoprostone	94-98	interleukin 1 beta	Homo sapiens	70-78
23583650-3	2013	We previously demonstrated that fibroblasts stimulated with IL-1beta increased their generation of the polysaccharide hyaluronan (HA) and increased their expression of the HA synthase enzyme (HAS-2).	Hyaluronic Acid	130-132	interleukin 1 beta	Homo sapiens	60-68
23117241-5	2013	Autophagy inhibition due to TNFR1 mutant proteins can be reversed, as demonstrated by the effects of the antibiotic geldanamycin, which was found to rescue the membrane localisation of mutant TNFR1 proteins, reduce their accumulation and counteract the increased inflammation by decreasing IL-1beta secretion.	geldanamycin	116-128	interleukin 1 beta	Homo sapiens	290-298
23485680-10	2013	Further, 4-ME significantly ameliorated the upregulated non-enzymatic inflammatory markers like TNF-alpha, IL-1beta, IL-6, COX-2 and PGE2.	4-methylesculetin	9-13	interleukin 1 beta	Homo sapiens	107-115
23499872-4	2013	Cambinol inhibited the expression of cytokines (TNF, IL-1beta, IL-6, IL-12p40, and IFN-gamma), NO and CD40 by macrophages, dendritic cells, splenocytes and whole blood stimulated with a broad range of microbial and inflammasome stimuli.	cambinol	0-8	interleukin 1 beta	Homo sapiens	53-61
23195574-9	2013	The effects of histone deacetylase (HDAC)-inhibition by trichostatin A (TSA) on IL-1beta and TNFalpha expression and their promoter structures were measured in promyeloid HL-60 cells.	trichostatin A	56-70	interleukin 1 beta	Homo sapiens	80-88
23507714-12	2013	Zymosan increased NLRP3 inflammasome and interleukin-1beta expression in glomus cells (p &lt; 0.01).	Zymosan	0-7	interleukin 1 beta	Homo sapiens	41-58
23195574-9	2013	The effects of histone deacetylase (HDAC)-inhibition by trichostatin A (TSA) on IL-1beta and TNFalpha expression and their promoter structures were measured in promyeloid HL-60 cells.	trichostatin A	72-75	interleukin 1 beta	Homo sapiens	80-88
23681674-0	2013	SeMet inhibits IL-1beta-induced rheumatoid fibroblast-like synoviocytes proliferation and the production of inflammatory mediators.	Selenomethionine	0-5	interleukin 1 beta	Homo sapiens	15-23
23681674-10	2013	SeMet also inhibited the production of PGE2 and NO induced by IL-1beta.	Selenomethionine	0-5	interleukin 1 beta	Homo sapiens	62-70
23681674-10	2013	SeMet also inhibited the production of PGE2 and NO induced by IL-1beta.	Dinoprostone	39-43	interleukin 1 beta	Homo sapiens	62-70
23149858-8	2013	As a result, we found that DMH-treated animals were having over-expression of various pro-inflammatory cytokines (IL-1beta, IL-2, and IFNgamma), aberrant nuclear localization of activated cell survival transcription factors (NF-kappaB and Stat3) along with the increased incidence of activated angiogenic factors (MMP-2 and MMP-9) suggesting a marked role of inflammation in the tumor progression.	1,2-Dimethylhydrazine	27-30	interleukin 1 beta	Homo sapiens	114-122
23885223-6	2013	Therefore, these results provide immunological information about amorphous silica nanoparticles and suggest that amorphous silica nanoparticles can evoke innate immune reactions in human monocytes through production of IL-1beta and IL-8.	Silicon Dioxide	123-129	interleukin 1 beta	Homo sapiens	219-227
23322512-6	2013	In the in vivo study, samples of subcutaneous AT from obese subjects obtained before and after treatment with 7,000 IU of vitamin D daily or placebo in a randomized controlled trial were stimulated with IL-1beta.	Vitamin D	122-131	interleukin 1 beta	Homo sapiens	203-211
23199585-8	2013	CAM also inhibited the IL-1beta production.	Clarithromycin	0-3	interleukin 1 beta	Homo sapiens	23-31
23199585-10	2013	CAM also inhibited the LPS-stimulated TNF-alpha, IL-1beta, IL-6 and IL-10 production.	Clarithromycin	0-3	interleukin 1 beta	Homo sapiens	49-57
23611575-2	2013	The administration of metformin reduced pain intensity from 9/10 to 3/10 and favorably affected the profile of inflammatory cytokines (i.e., TNF a, IL-1beta, IL-6, and IL-10), adipokines (i.e., adiponectin, leptin, and resistin), and beta-endorphin.	Metformin	22-31	interleukin 1 beta	Homo sapiens	148-156
23578284-0	2013	IL-1beta and TNF-alpha induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase.	Glutamic Acid	52-61	interleukin 1 beta	Homo sapiens	0-8
23683276-8	2013	Ketoprofen effectively inhibited interleukin-1beta and tumor necrosis factor alpha production in LPS-stimulated dental pulp cells.	Ketoprofen	0-10	interleukin 1 beta	Homo sapiens	33-82
23006543-10	2013	IL-1beta secretion was inhibited by ZYVAD, a caspase inhibitor.	zyvad	36-41	interleukin 1 beta	Homo sapiens	0-8
23452206-8	2013	CSC-induced NF-kappaB activation, IL-1beta promoter activity, IL-1beta mRNA upregulation, and CYP1A1 mRNA induction were all inhibited by an aryl hydrocarbon receptor (AhR) antagonist alpha-naphthoflavone.	alpha-naphthoflavone	184-204	interleukin 1 beta	Homo sapiens	62-70
23734999-6	2013	By contrast, treatments with beta-caryophyllene dose-dependently inhibited mRNA expression of inducible nitric oxide synthetase, interleukin (IL)-1beta, IL-6, and cyclooxygenase 2 in C6 microglial cells, and decreased the level of nitric oxide and prostaglandin E2 at a 100 muM concentration.	caryophyllene	29-47	interleukin 1 beta	Homo sapiens	129-151
23578284-5	2013	Furthermore, both intracellular and extracellular glutamate levels were significantly elevated following IL-1beta and/or TNF-alpha treatment.	Glutamic Acid	50-59	interleukin 1 beta	Homo sapiens	105-113
23578284-6	2013	Pre-treatment with N-Methyl-D-aspartate (NMDA) receptor antagonist MK-801 blocked cytokine-induced glutamate production and alleviated the neurotoxicity, indicating that IL-1beta and/or TNF-alpha induce neurotoxicity through glutamate.	Dizocilpine Maleate	67-73	interleukin 1 beta	Homo sapiens	170-178
23578284-7	2013	To determine the potential source of excess glutamate production in the culture during inflammation, we investigated the neuronal glutaminase and found that treatment with IL-1beta or TNF-alpha significantly upregulated the kidney-type glutaminase (KGA), a glutaminase 1 isoform, in primary human neurons.	Glutamic Acid	44-53	interleukin 1 beta	Homo sapiens	172-180
23739567-7	2013	The protein expressions of IL-1beta and IL-6 proteins and the mRNA expression of IL-1beta in PDs group were significantly higher than those in PHs group, while the expressions of IL-10 protein and IL-10 mRNA were evidently lowered (all P&lt;0.05).	Palladium	93-96	interleukin 1 beta	Homo sapiens	27-35
23615449-5	2013	Our results show that in RINm5F cells and human primary beta-cells, IL-1beta alters mitochondrial membrane potential, mitochondrial permeability transition pore opening, ATP content, and reactive oxygen species production and these alterations are preceded by ER Ca(2+) release via IP3R channels and mitochondrial Ca(2+) uptake.	Adenosine Triphosphate	170-173	interleukin 1 beta	Homo sapiens	68-76
23615449-5	2013	Our results show that in RINm5F cells and human primary beta-cells, IL-1beta alters mitochondrial membrane potential, mitochondrial permeability transition pore opening, ATP content, and reactive oxygen species production and these alterations are preceded by ER Ca(2+) release via IP3R channels and mitochondrial Ca(2+) uptake.	Reactive Oxygen Species	187-210	interleukin 1 beta	Homo sapiens	68-76
23615449-7	2013	This is accompanied by IL-1beta-induced apoptosis, which is prevented by JNK1/2 siRNA and the IP3R inhibitor xestospongin C.	xestospongin C	109-123	interleukin 1 beta	Homo sapiens	23-31
22903493-4	2013	Moreover, nuclear factor (NF)-kappaB signaling activation through IkappaB-alpha degradation, IkappaB kinase (IKK)-alpha/beta, and p-65 phosphorylation was restored by cinnamophilin upon IL-1beta stimulation.	cinnamophilin	167-180	interleukin 1 beta	Homo sapiens	186-194
22903493-5	2013	Importantly, results showed that IL-1beta-induced activation of phosphorylated (p)-c-Jun in chondrocytes was significantly inhibited by cinnamophilin.	cinnamophilin	136-149	interleukin 1 beta	Homo sapiens	33-41
22903493-6	2013	These results indicate that cinnamophilin inhibited MMP-1 and -13 expressions in IL-1beta-treated chondrocytes through either NF-kappaB or ERK/p38 MAPK downregulation and/or suppressing p-c-Jun pathways.	cinnamophilin	28-41	interleukin 1 beta	Homo sapiens	81-89
23392593-0	2013	Delphinidin inhibits IL-1beta-induced activation of NF-kappaB by modulating the phosphorylation of IRAK-1(Ser376) in human articular chondrocytes.	delphinidin	0-11	interleukin 1 beta	Homo sapiens	21-29
23392593-3	2013	In the present study we determined whether delphinidin would inhibit the IL-1beta-induced activation of NF-kappaB in human chondrocytes and determined the mechanism of its action.	delphinidin	43-54	interleukin 1 beta	Homo sapiens	73-81
23803194-8	2013	Mannan treatment increased the expressions of IL-1beta, TNF-alpha, IL-6 and CD11b and enhanced superoxide production in the PMNs.	Mannans	0-6	interleukin 1 beta	Homo sapiens	46-54
22903493-3	2013	Cinnamophilin strongly inhibited MMP-1 and -13 induction in IL-1beta-treated (30 ng/mL) SW1353 cells in a concentration-dependent manner, and it also reduced MAPK family members including extracellular signal-regulated kinase (ERK), p38 MAPKs, and c-Jun N-terminal kinase.	cinnamophilin	0-13	interleukin 1 beta	Homo sapiens	60-68
23392593-7	2013	RESULTS: Delphinidin inhibited IL-1beta-induced expression of COX-2 and production of PGE2 in human chondrocytes.	delphinidin	9-20	interleukin 1 beta	Homo sapiens	31-39
23392593-7	2013	RESULTS: Delphinidin inhibited IL-1beta-induced expression of COX-2 and production of PGE2 in human chondrocytes.	Dinoprostone	86-90	interleukin 1 beta	Homo sapiens	31-39
23392593-8	2013	Delphinidin also inhibited IL-1beta-mediated phosphorylation of IL-1 receptor-associated kinase-1(Ser376), phosphorylation of IKKalpha/beta, expression of IKKbeta, degradation of IkappaBalpha, and activation and nuclear translocation of NF-kappaB/p65.	delphinidin	0-11	interleukin 1 beta	Homo sapiens	27-35
23392593-9	2013	Phosphorylation of TGF-beta-activated kinase 1 was not observed but NF-kappaB-inducing kinase (NIK) was phosphorylated and phosphorylation of NIK was blocked by delphinidin in IL-1beta-treated human chondrocytes.	delphinidin	161-172	interleukin 1 beta	Homo sapiens	176-184
23392593-10	2013	CONCLUSION: These data identify delphinidin as a novel inhibitor of IL-1beta-induced production of cartilage-degrading molecule PGE2 via inhibition of COX-2 expression and provide new insight into the mechanism of its action.	delphinidin	32-43	interleukin 1 beta	Homo sapiens	68-76
23392593-10	2013	CONCLUSION: These data identify delphinidin as a novel inhibitor of IL-1beta-induced production of cartilage-degrading molecule PGE2 via inhibition of COX-2 expression and provide new insight into the mechanism of its action.	Dinoprostone	128-132	interleukin 1 beta	Homo sapiens	68-76
23392593-11	2013	Our results also identify inhibition of IRAK1(Ser376) phosphorylation by delphinidin in IL-1beta-induced activation of NF-kappaB in human chondrocytes.	delphinidin	73-84	interleukin 1 beta	Homo sapiens	88-96
23392593-12	2013	Given the important role played by IL-1beta-induced NF-kappaB activation, COX-2 expression and PGE2 production in OA, our results may have important implications for the development of novel therapeutic strategies for the prevention/treatment of OA.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	35-43
23739567-7	2013	The protein expressions of IL-1beta and IL-6 proteins and the mRNA expression of IL-1beta in PDs group were significantly higher than those in PHs group, while the expressions of IL-10 protein and IL-10 mRNA were evidently lowered (all P&lt;0.05).	Palladium	93-96	interleukin 1 beta	Homo sapiens	81-89
23738004-1	2013	BACKGROUND: The toll-like receptor (TLR)4-interleukin1beta (IL1beta) signaling pathway is involved in the monosodium urate (MSU)-mediated inflammation.	Uric Acid	106-122	interleukin 1 beta	Homo sapiens	60-67
23738004-1	2013	BACKGROUND: The toll-like receptor (TLR)4-interleukin1beta (IL1beta) signaling pathway is involved in the monosodium urate (MSU)-mediated inflammation.	Uric Acid	124-127	interleukin 1 beta	Homo sapiens	60-67
23333441-5	2013	Here we have compared the responses of articular chondrocytes seeded within three different polymeric scaffolding materials (silk, collagen and polylactic acid (PLA)) to IL-1beta and TNFalpha.	poly(lactide)	144-159	interleukin 1 beta	Homo sapiens	170-178
23717592-9	2013	We also found that pro-inflammatory cytokines, IL-1beta and TNFalpha, are potent inducers of DeltaNp73alpha, which further enhance the bile acids/acid effect.	Bile Acids and Salts	135-145	interleukin 1 beta	Homo sapiens	47-55
23660804-13	2013	RANTES expression increased more than 200-fold in the alginate culture model in cells treated with IL-1beta/TNF-alpha, 1% fetal bovine serum (P &lt; 0.001).	Alginates	54-62	interleukin 1 beta	Homo sapiens	99-107
23530046-10	2013	Acidic medium triggered pH-dependent secretion of IL-1beta and activation of caspase-1 via a mechanism involving potassium efflux from the cells.	Potassium	113-122	interleukin 1 beta	Homo sapiens	50-58
23530046-11	2013	Acidic extracellular pH caused rapid intracellular acidification, and the IL-1beta-inducing effect of acidic medium could be mimicked by acidifying the cytosol with bafilomycin A1, a proton pump inhibitor.	bafilomycin A1	165-179	interleukin 1 beta	Homo sapiens	74-82
23591198-0	2013	Serum levels of IL-6 and IL-1beta can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer.	gemcitabine	62-73	interleukin 1 beta	Homo sapiens	25-33
23710297-6	2013	RESULTS: We found that pro-IL-1beta was processed to mature IL-1beta in LPS-activated fresh and overnight cultured human monocytes in response to ATP stimulation.	Adenosine Triphosphate	146-149	interleukin 1 beta	Homo sapiens	23-35
23710297-6	2013	RESULTS: We found that pro-IL-1beta was processed to mature IL-1beta in LPS-activated fresh and overnight cultured human monocytes in response to ATP stimulation.	Adenosine Triphosphate	146-149	interleukin 1 beta	Homo sapiens	27-35
23458894-9	2013	Crotonaldehyde-stimulated macrophages also amplify the inflammatory response by enhancing IL-8 release from airway epithelial cells mediated by NF-kappaB and AP-1 pathways through a mechanism involving TNF-alpha and IL-1beta.	2-butenal	0-14	interleukin 1 beta	Homo sapiens	216-224
22964727-9	2013	Administration of 250-muM lipid chlorohydrins, which is the concentration found in ascitic fluid, induces the expression of TNFalpha and interleukin-1beta in peritoneal macrophages and increases the systemic inflammatory response in pancreatitis.	Chlorohydrins	32-45	interleukin 1 beta	Homo sapiens	137-154
23351078-7	2013	The burst of intracellular calcium induced by either bradykinin (B2 agonist) or des-Arg(10) -Lys-bradykinin (B1 agonist) in gingival fibroblasts pretreated with IL-1beta was impaired by IL-4.	Calcium	27-34	interleukin 1 beta	Homo sapiens	161-169
23355332-5	2013	15-HETE-enhanced lysozyme release was abrogated by anti-TNF-alpha and anti-IL-1beta-blocking antibodies and mimicked by recombinant cytokines; on the contrary, MIP-1alpha/CCL3 was not involved as a soluble mediator of 15-HETE effects.	15-Hete	0-7	interleukin 1 beta	Homo sapiens	75-83
23500137-3	2013	In this study, we evaluated the anti-inflammatory activity and mechanisms of propofol on lipopolysaccharide (LPS)-induced inflammation in vivo and in vitro and found that propofol markedly inhibited LPS-induced production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6, and expression of inducible nitric oxide synthase (iNOS).	Propofol	171-179	interleukin 1 beta	Homo sapiens	298-320
23568097-0	2013	Do interleukin-1beta levels correlate with MIBG and exercise parameters in heart failure?	3-Iodobenzylguanidine	43-47	interleukin 1 beta	Homo sapiens	3-20
23434541-3	2013	Extracellular ATP can cause P2X receptors to activate the NOD-like receptor 3 (NLRP3) inflammasome and cause IL-1beta and IL-18 maturation and release.	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	109-117
23850670-5	2013	Poly I:C synergistically enhanced CCL20 expression from IL-1beta-stimulated HGFs.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	56-64
23850670-7	2013	Western blot analysis disclosed phosphorylation of p38 MAPK, JNK, and IkappaB-alpha were enhanced in Poly I:C/IL-1beta-treated HGFs.	Poly I	101-107	interleukin 1 beta	Homo sapiens	110-118
23507189-3	2013	In the present study we evaluated an extract of C. sanguinolenta (CSE) and cryptolepine (CAS) on neuroinflammation induced with IL-1beta in SK-N-SH neuroblastoma cells.	cryptolepine	75-87	interleukin 1 beta	Homo sapiens	128-136
23507189-9	2013	Studies on CAS showed significant and dose-dependent inhibition of TNFalpha, IL-6 and PGE2 production in IL-1beta-stimulated cells without affecting viability.	Dinoprostone	86-90	interleukin 1 beta	Homo sapiens	105-113
23583898-4	2013	Here, we show that thalidomide suppressed TNF-alpha-induced NF-kappaB activation and ATP-induced IL-1beta secretion, but did not interrupt the production of IL-1beta, IL-6, IL-8, and TNF-alpha in response to lipopolysaccharide in CGD monocytes.	Thalidomide	19-30	interleukin 1 beta	Homo sapiens	97-105
23583898-4	2013	Here, we show that thalidomide suppressed TNF-alpha-induced NF-kappaB activation and ATP-induced IL-1beta secretion, but did not interrupt the production of IL-1beta, IL-6, IL-8, and TNF-alpha in response to lipopolysaccharide in CGD monocytes.	Adenosine Triphosphate	85-88	interleukin 1 beta	Homo sapiens	97-105
23434541-8	2013	In vitro culture experiments showed NLRP3 protein expression, cleavage of caspase-1 and IL-1beta, and release of IL-1beta, IL-18 and ATP in HK-2 cells significantly increased after high glucose stimulation.	Glucose	186-193	interleukin 1 beta	Homo sapiens	88-96
23434541-8	2013	In vitro culture experiments showed NLRP3 protein expression, cleavage of caspase-1 and IL-1beta, and release of IL-1beta, IL-18 and ATP in HK-2 cells significantly increased after high glucose stimulation.	Glucose	186-193	interleukin 1 beta	Homo sapiens	113-121
23441755-6	2013	RESULTS: IL-1beta increased PGE2 production and COX-1 protein expression in control-NM fibroblasts, but no changes were found in AIA-NM.	Dinoprostone	28-32	interleukin 1 beta	Homo sapiens	9-17
23047422-6	2013	In contrast, clonidine at &lt;10(-9) M increased IL-6, while at &gt;10(-5) M increased IL-1beta and decreased TNF-alpha levels.	Clonidine	13-22	interleukin 1 beta	Homo sapiens	87-95
23681030-16	2013	Dexamethasone use significantly reduced postoperative levels of C-reactive protein (P = .01) and interleukin 6 and interleukin 1beta (P = .02), fatigue (P = .01), and overall pain during the first 24 postoperative hours (P = .04), as well as the total analgesic (ketorolac tromethamine) requirement (P = .04).	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	115-132
23631691-9	2013	Furthermore, TNF-alpha and IL-1beta secretion in PAMs from group LP was statistically greater than those from the control group after stimulation with either poly(I:C) or CL097.	leucylproline	65-67	interleukin 1 beta	Homo sapiens	27-35
23488692-0	2013	IL-1beta/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	0-8
23488692-6	2013	We aimed to investigate the effects of IL-1beta/HMGB1 complexes on mPGES-1 and other enzymes of the PGE2 pathway in synovial fibroblasts (SFs) from patients with arthritis.	Dinoprostone	100-104	interleukin 1 beta	Homo sapiens	39-47
23488692-8	2013	Stimulation of SFs with HMGB1 in complex with suboptimal amounts of IL-1beta significantly increased mPGES-1 and COX-2 expressions as well as PGE2 production, as compared to treatment with HMGB1 or IL-1beta alone.	SFS	15-18	interleukin 1 beta	Homo sapiens	68-76
23488692-8	2013	Stimulation of SFs with HMGB1 in complex with suboptimal amounts of IL-1beta significantly increased mPGES-1 and COX-2 expressions as well as PGE2 production, as compared to treatment with HMGB1 or IL-1beta alone.	SFS	15-18	interleukin 1 beta	Homo sapiens	198-206
23488692-8	2013	Stimulation of SFs with HMGB1 in complex with suboptimal amounts of IL-1beta significantly increased mPGES-1 and COX-2 expressions as well as PGE2 production, as compared to treatment with HMGB1 or IL-1beta alone.	Dinoprostone	142-146	interleukin 1 beta	Homo sapiens	68-76
23488692-9	2013	Furthermore, NS-398 reduced the production of IL-6 and IL-8, thus indicating that IL-1beta/HMGB1 complexes modulate cytokine production in part through prostanoid synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-19	interleukin 1 beta	Homo sapiens	82-90
23488692-9	2013	Furthermore, NS-398 reduced the production of IL-6 and IL-8, thus indicating that IL-1beta/HMGB1 complexes modulate cytokine production in part through prostanoid synthesis.	Prostaglandins	152-162	interleukin 1 beta	Homo sapiens	82-90
23488692-11	2013	IL-1beta/HMGB1 complexes promote the induction of mPGES-1, COX-2 and PGE2 in SF.	Dinoprostone	69-73	interleukin 1 beta	Homo sapiens	0-8
23631691-12	2013	HP enhanced production of TNF-alpha, IL-1beta, and IL-6 in PBMCs following CL097-stimulation more than LP and LP-der, whereas LP enhanced the secretion of TNF-alpha and IL-1beta in poly(I:C)- and CL097-stimulated PAMs.	histidylproline	0-2	interleukin 1 beta	Homo sapiens	37-45
23631691-12	2013	HP enhanced production of TNF-alpha, IL-1beta, and IL-6 in PBMCs following CL097-stimulation more than LP and LP-der, whereas LP enhanced the secretion of TNF-alpha and IL-1beta in poly(I:C)- and CL097-stimulated PAMs.	histidylproline	0-2	interleukin 1 beta	Homo sapiens	169-177
23898520-10	2013	Effects of SB203580 (a selective p38MAPK inhibitor) on expression of TNF-alpha and IL-1beta in intestinal mucosal biopsy specimens from patients with ulcerative colitis were determined on condition of tissue culture.	SB 203580	11-19	interleukin 1 beta	Homo sapiens	83-91
23549814-9	2013	IL-1beta-induced MUC5AC mRNA expression was decreased by MbetaCD and this decrease occurred IL-1-receptor- specifically.	methyl-beta-cyclodextrin	57-64	interleukin 1 beta	Homo sapiens	0-8
23549814-10	2013	Moreover, we have shown that MbetaCD suppressed the activation of ERK1/2 and p38 MAPK in cells activated with IL-1beta.	methyl-beta-cyclodextrin	29-36	interleukin 1 beta	Homo sapiens	110-118
23549814-11	2013	This result suggests that MbetaCD-mediated suppression of IL-1beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathway.	methyl-beta-cyclodextrin	26-33	interleukin 1 beta	Homo sapiens	58-66
23631691-9	2013	Furthermore, TNF-alpha and IL-1beta secretion in PAMs from group LP was statistically greater than those from the control group after stimulation with either poly(I:C) or CL097.	Poly I-C	158-167	interleukin 1 beta	Homo sapiens	27-35
23631691-9	2013	Furthermore, TNF-alpha and IL-1beta secretion in PAMs from group LP was statistically greater than those from the control group after stimulation with either poly(I:C) or CL097.	CL097	171-176	interleukin 1 beta	Homo sapiens	27-35
23631691-11	2013	CONCLUSIONS: We found that HP was a stronger inducer of TLR 3, 7, and 8 expression and IL-1beta, IL-6, TNF-alpha, and IFN-gamma production compared to LP and LP-der.	histidylproline	27-29	interleukin 1 beta	Homo sapiens	87-95
23592003-6	2013	The C/C genotype of IL-1beta was also higher in CP patients (51%) than in controls (21%) (p&amp;lt;0.0001).	Adenosine Monophosphate	92-95	interleukin 1 beta	Homo sapiens	20-28
23628149-7	2013	Compared with E group, EC group showed renal tissue IL-1beta, IL-6, TNF-alpha and NF-KB expression decreased significantly, respectively (p &lt; 0.05).	ec	23-25	interleukin 1 beta	Homo sapiens	52-60
23513060-4	2013	RESULTS: Exposure to IL-6 at concentrations of 1 and 10 ng/mL and IL-1beta at 10 ng/mL significantly decreased CCh-induced Cl(-) secretion.	Carbachol	111-114	interleukin 1 beta	Homo sapiens	66-74
23434081-8	2013	The levels of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IL-10) in piglet plasma of the NAC group (mixed feeding concentration of 1200 mg/kg) were significantly lower at 3h after LPS stimulation (P&lt;0.05).	Acetylcysteine	100-103	interleukin 1 beta	Homo sapiens	49-57
23637950-4	2013	PRINCIPAL FINDINGS: Serum-differentiated macrophages stimulated with beta-glucans showed a low production of TNFalpha and IL-1beta, a high production of IL-6 and IL-23, and a delayed induction of cyclooxygenase-2 and PGE2 biosynthesis that resembled the responses elicited by crystals and those produced when phagosomal degradation of the phagocytic cargo increases ligand access to intracellular pattern recognition receptors.	beta-Glucans	69-81	interleukin 1 beta	Homo sapiens	122-130
23458918-8	2013	RESULTS: 10% and 20% (v/v) FYD-CS significantly decreased NO production in a concentration-dependent manner (p&lt;0.05 or p&lt;0.01) as compared to control in IL-1beta-induced SW1353 cells.	fyd-cs	27-33	interleukin 1 beta	Homo sapiens	159-167
23458918-10	2013	Furthermore, 10% and 20% FYD-CS markedly decreased IkappaBalpha degradation by about 45% and 26% (p&lt;0.01 or p&lt;0.05), lessened P65 content in the nucleus by about 28% and 60% (both p&lt;0.01), and repressed DNA binding activity of P65 by about 30% and 45% (both p&lt;0.01) in IL-1beta-induced SW1353 cells.	fyd-cs	25-31	interleukin 1 beta	Homo sapiens	281-289
23616769-8	2013	EGCG inhibited interleukin (IL)-1beta, transforming growth factor beta, IL-8, and chemokine (C-C motif) ligand 2 (CCL2) release by stimulated FLS and/or THP-1 cells in a dose-dependent manner.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	15-37
23479230-3	2013	Alarmins, such as ATP, likely play a pivotal role in the induction and maintenance of cutaneous immune responses by stimulating DC maturation, chemotaxis, and secretion of IL-1beta and IL-6, Th17-biasing cytokines.	Adenosine Triphosphate	18-21	interleukin 1 beta	Homo sapiens	172-180
23637886-4	2013	And H(H2O)m significantly prevented UV-induced MMP-1, COX-2, IL-6 and IL-1beta mRNA expressions in human skin in vivo.	Water	6-9	interleukin 1 beta	Homo sapiens	70-78
23637886-7	2013	In intrinsically aged skin, H(H2O)m application significantly reduced constitutive expressions of MMP-1, IL-6, and IL-1beta mRNA.	Water	30-33	interleukin 1 beta	Homo sapiens	115-123
23430110-10	2013	In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases.	Arsenic Trioxide	38-54	interleukin 1 beta	Homo sapiens	97-105
23430110-10	2013	In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases.	Uric Acid	66-82	interleukin 1 beta	Homo sapiens	97-105
23430110-10	2013	In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases.	Uric Acid	84-87	interleukin 1 beta	Homo sapiens	97-105
23687429-8	2013	In addition, 6.25 muM H2O2 led to significant elevation of the levels of transforming growth factor, beta 1, interleukin-1beta, and superoxide anion in GO fibroblasts, but no significant change in the normal controls.	Hydrogen Peroxide	22-26	interleukin 1 beta	Homo sapiens	109-126
23687429-9	2013	Pretreatment with N-acetylcysteine or vitamin C reversed the enhanced proliferation capacity and the induction of transforming growth factor, beta 1, interleukin-1beta and superoxide anion of GO fibroblasts in response to 6.25 muM H2O2.	Acetylcysteine	18-34	interleukin 1 beta	Homo sapiens	150-167
23687429-9	2013	Pretreatment with N-acetylcysteine or vitamin C reversed the enhanced proliferation capacity and the induction of transforming growth factor, beta 1, interleukin-1beta and superoxide anion of GO fibroblasts in response to 6.25 muM H2O2.	Ascorbic Acid	38-47	interleukin 1 beta	Homo sapiens	150-167
23687429-9	2013	Pretreatment with N-acetylcysteine or vitamin C reversed the enhanced proliferation capacity and the induction of transforming growth factor, beta 1, interleukin-1beta and superoxide anion of GO fibroblasts in response to 6.25 muM H2O2.	Hydrogen Peroxide	231-235	interleukin 1 beta	Homo sapiens	150-167
23461871-6	2013	IL1beta was sufficient to inhibit adipogenesis on its own, and this was blocked by SC-514, an IKKbeta inhibitor, as has been reported for THP-1-MacCM.	SC 514	83-89	interleukin 1 beta	Homo sapiens	0-7
23253918-10	2013	Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha.	Nigericin	65-74	interleukin 1 beta	Homo sapiens	151-159
23585849-4	2013	Omentum-derived MCs treated with TGF-beta1 plus IL-1beta (in vitro MMT) and PD effluent-derived MCs with non-epithelioid phenotype (ex vivo MMT) showed down-regulated expression of the two main receptors Flt-1/VEGFR-1 and KDR/VEGFR-2, whereas the co-receptor neuropilin-1 (Nrp-1) was up-regulated.	mcs	16-19	interleukin 1 beta	Homo sapiens	48-56
23593222-2	2013	Ligand stimulation with either cortisone or dexamethsone (DEX) acutely elicited GR translocation to the nucleus and, comparably, ligand-independent stimulation either with the Th2 cytokine, IL-13, or the pleiotropic cytokine combination, IL-1beta/TNFalpha, also acutely evoked GR translocation.	Cortisone	31-40	interleukin 1 beta	Homo sapiens	238-246
23593222-2	2013	Ligand stimulation with either cortisone or dexamethsone (DEX) acutely elicited GR translocation to the nucleus and, comparably, ligand-independent stimulation either with the Th2 cytokine, IL-13, or the pleiotropic cytokine combination, IL-1beta/TNFalpha, also acutely evoked GR translocation.	dexamethsone	44-56	interleukin 1 beta	Homo sapiens	238-246
23593222-2	2013	Ligand stimulation with either cortisone or dexamethsone (DEX) acutely elicited GR translocation to the nucleus and, comparably, ligand-independent stimulation either with the Th2 cytokine, IL-13, or the pleiotropic cytokine combination, IL-1beta/TNFalpha, also acutely evoked GR translocation.	dex	58-61	interleukin 1 beta	Homo sapiens	238-246
23253918-10	2013	Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha.	Uric Acid	44-53	interleukin 1 beta	Homo sapiens	151-159
23146110-9	2013	KEY RESULTS: Andrographolide suppressed cigarette smoke-induced increases in lavage fluid cell counts; levels of IL-1beta, MCP-1, IP-10 and KC; and levels of oxidative biomarkers 8-isoprostane, 8-OHdG and 3-nitrotyrosine in a dose-dependent manner.	andrographolide	13-28	interleukin 1 beta	Homo sapiens	113-121
23593315-5	2013	In vitro, minocycline was found to significantly suppress both constitutive and IL-1beta or 4-hydroxyestradiol (4-OH-E2)-stimulated IL-6 expression in human ovarian cancer cells; OVCAR-3, SKOV-3 and CAOV-3.	Minocycline	10-21	interleukin 1 beta	Homo sapiens	80-88
22993202-8	2013	The impact of BA on the inflammatory response was investigated in vitro using Caco-2 cells stimulated by IL-1beta.	Bile Acids and Salts	14-16	interleukin 1 beta	Homo sapiens	105-113
23159435-4	2013	RESULTS: Simvastatin, but not placebo, reduced monocyte release of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta and monocyte chemoattractant protein-1, as well decreased plasma levels of C-reactive protein.	Simvastatin	9-20	interleukin 1 beta	Homo sapiens	111-128
24376319-0	2013	Uric acid induces caspase-1 activation, IL-1beta secretion and P2X7 receptor dependent proliferation in primary human lymphocytes.	Uric Acid	0-9	interleukin 1 beta	Homo sapiens	40-48
24376319-1	2013	BACKGROUND: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1beta (IL-1beta).	Uric Acid	12-17	interleukin 1 beta	Homo sapiens	190-198
24376319-8	2013	RESULTS: Urate induced caspase-1 activation and IL-1beta release by lymphocytes.	Uric Acid	9-14	interleukin 1 beta	Homo sapiens	48-56
23603366-2	2013	Western blot analysis identified 21 kDa lipocalin (L)-prostaglandin D2 (PGD2) synthase (S) in human osteoarthritis (OA)-affected cartilage, whose expression was increased by IL-1beta and TNFalpha.	21 kda lipocalin	33-49	interleukin 1 beta	Homo sapiens	174-182
23278511-4	2013	Intracellular ROS have been implicated in NLRP3 inflammasome-mediated IL-1beta production, therefore, we aimed to study whether RWE influences the function of NLRP3 inflammasome.	Reactive Oxygen Species	14-17	interleukin 1 beta	Homo sapiens	70-78
23278511-5	2013	Here we describe that, in the presence of NADPH, RWE significantly elevates lipopolysaccharide-induced IL-1beta production of THP-1 cells as well as human primary macrophages and dendritic cells.	NADP	42-47	interleukin 1 beta	Homo sapiens	103-111
23278511-7	2013	We provide evidence that RWE elevates cytosolic ROS level in these cells, and ROS inhibitors abolish IL-1beta production.	Reactive Oxygen Species	78-81	interleukin 1 beta	Homo sapiens	101-109
23278511-8	2013	Furthermore, we show that RWE enhances lipopolysaccharide-induced gene transcription/expression of pro-IL-1beta and key components of the inflammasome via a ROS-dependent mechanism.	Reactive Oxygen Species	157-160	interleukin 1 beta	Homo sapiens	99-111
23603366-5	2013	Similarly, PGD2 (but not 13,14-dihydro-15-keto PGD2) augmented IL-1beta induced PGE2 but inhibited IL-beta induced nitric oxide (NO) in human chondrocytes.	Prostaglandin D2	11-15	interleukin 1 beta	Homo sapiens	63-71
23603366-7	2013	Furthermore, celecoxib (1 muM) counter balances (IL-1beta induced+PGD2 modulated) levels of NO and PGE2 in human OA-affected cartilage and chondrocytes to basal levels.	Celecoxib	13-22	interleukin 1 beta	Homo sapiens	49-57
22925444-3	2013	TNF-alpha and IL-1beta release on titanium stimulation were significantly higher among patients with implant loss (TNF-alpha: 256.89 pg/ml vs. 81.4 pg/ml; p&lt;0.0001; IL-1beta: 159.96 pg/ml vs. 54.01 pg/ml; p&lt;0.0001).	Titanium	34-42	interleukin 1 beta	Homo sapiens	14-22
23443505-0	2013	Nicotine favors osteoclastogenesis in human periodontal ligament cells co-cultured with CD4(+) T cells by upregulating IL-1beta.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	119-127
23443505-8	2013	Compared with mono-culture systems, stimulation with nicotine caused an increased secretion of IL-1beta in serum of human PDL cell-CD4(+) T cell co-culture, and the expression of RANKL in human PDL cells was further upregulated co-cultured with CD4(+) T cells, while no differences were observed in the expression of OPG between the co-culture and mono-culture systems.	Nicotine	53-61	interleukin 1 beta	Homo sapiens	95-103
23443505-9	2013	Our data suggested that nicotine upregulated IL-1beta secretion, further upregulated RANKL expression in smoking-associated periodontitis, which may aid in the better understanding of the relationship between nicotine and alveolar bone resorption.	Nicotine	24-32	interleukin 1 beta	Homo sapiens	45-53
23443505-9	2013	Our data suggested that nicotine upregulated IL-1beta secretion, further upregulated RANKL expression in smoking-associated periodontitis, which may aid in the better understanding of the relationship between nicotine and alveolar bone resorption.	Nicotine	209-217	interleukin 1 beta	Homo sapiens	45-53
22925444-3	2013	TNF-alpha and IL-1beta release on titanium stimulation were significantly higher among patients with implant loss (TNF-alpha: 256.89 pg/ml vs. 81.4 pg/ml; p&lt;0.0001; IL-1beta: 159.96 pg/ml vs. 54.01 pg/ml; p&lt;0.0001).	Titanium	34-42	interleukin 1 beta	Homo sapiens	168-176
22925444-7	2013	IL-1/IL1RN/TNFA genotyping and cytokine release assay scores provide prognostic markers for titanium implant outcome and may present new tools for individual risk assessment.	Titanium	92-100	interleukin 1 beta	Homo sapiens	0-4
23219088-3	2013	Furthermore, pyruvate suppressed the UVB-induced mRNA expression of inflammatory mediators such as interleukin (IL)-1alpha, IL-1beta, IL-6 and cyclooxygenase-2 (Cox-2).	Pyruvic Acid	13-21	interleukin 1 beta	Homo sapiens	124-132
23085747-7	2013	Patients with POCD had significantly higher IL-1beta, Tau/Abeta1-42, pTau/Abeta1-42, and a lower level of Abeta1-42 in CSF when compared with the Non-POCD group (P &lt; 0.05).	pocd	14-18	interleukin 1 beta	Homo sapiens	44-52
22967010-3	2013	Aluminum adjuvants promote oxidative stress and increase inflammasome activity, leading to the release of IL-1beta, IL-18, and IL-33, but not the important regulatory cytokine IL-12.	Aluminum	0-8	interleukin 1 beta	Homo sapiens	106-114
23012315-4	2013	In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells.	Vitamin D	24-33	interleukin 1 beta	Homo sapiens	108-116
23474372-8	2013	The analgesic mechanisms of piracetam were related to inhibition of carrageenin- and TNF-alpha-induced production of IL-1beta as well as prevention of carrageenin-induced decrease of reduced glutathione, ferric reducing ability and free radical scavenging ability in the paw.	Piracetam	28-37	interleukin 1 beta	Homo sapiens	117-125
23474372-8	2013	The analgesic mechanisms of piracetam were related to inhibition of carrageenin- and TNF-alpha-induced production of IL-1beta as well as prevention of carrageenin-induced decrease of reduced glutathione, ferric reducing ability and free radical scavenging ability in the paw.	Carrageenan	68-79	interleukin 1 beta	Homo sapiens	117-125
22881405-11	2013	RESULTS: Mechanical stress could up-regulate IL-1beta expression through the release of ATP in HPDL cells.	Adenosine Triphosphate	88-91	interleukin 1 beta	Homo sapiens	45-53
22881405-12	2013	ATP alone was also capable of increasing IL-1beta expression.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	41-49
22881405-14	2013	ATP-stimulated IL-1beta expression was also diminished by intracellular calcium inhibitors.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	15-23
22881405-14	2013	ATP-stimulated IL-1beta expression was also diminished by intracellular calcium inhibitors.	Calcium	72-79	interleukin 1 beta	Homo sapiens	15-23
22881405-16	2013	The results signified the important roles of ATP/P2 purinergic receptors, as well as intracellular calcium signaling, in mechanical stress-induced inflammation via up-regulation of the proinflammatory cytokine, IL-1beta, in HPDL cells.	Calcium	99-106	interleukin 1 beta	Homo sapiens	211-219
22934794-10	2013	Furthermore, in the presence of red complex, CT + TT genotypes were associated with higher interleukin -1beta levels and severe GO.	Carbon Tetrachloride	45-47	interleukin 1 beta	Homo sapiens	91-109
23012315-6	2013	Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	26-34
23012315-7	2013	Western analysis showed that vitamin D decreased MCP-1, TLR-4, and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1beta.	Vitamin D	29-38	interleukin 1 beta	Homo sapiens	147-155
23349235-6	2013	In an implantation model of AC-1M88 trophoblast spheroids on a monolayer of T-HESC, spheroid expansion was enhanced in the presence of HB-EGF/IL-1beta/LIF.	-1m88	30-35	interleukin 1 beta	Homo sapiens	142-150
23643169-5	2013	After the outer membrane of E.coli DH5alpha was broken (spheroplast formation), the bacteria were incubated with mouse anti-hIL-1beta antibody labeled by FITC.	Fluorescein-5-isothiocyanate	154-158	interleukin 1 beta	Homo sapiens	124-133
23414138-5	2013	Cellular screening in BEAS-2B and THP-1 cells showed that, compared to AP-MWCNTs, anionic functionalization (COOH and PEG) decreased the production of pro-fibrogenic cytokines and growth factors (including IL-1beta, TGF-beta1, and PDGF-AA), while neutral and weak cationic functionalization (NH2 and sw-NH2) showed intermediary effects.	Carbonic Acid	109-113	interleukin 1 beta	Homo sapiens	206-214
23438438-3	2013	The aim of this study was to clarify the mechanisms of expression of ADAMTS4 induced by IL-1beta in human fibroblast-like synoviocyte (HFLS) cells by high molecular weight hyaluronan (HMW-HA), a therapeutic agent used for OA.	Hyaluronic Acid	172-182	interleukin 1 beta	Homo sapiens	88-96
23386602-6	2013	Autophagy induction against B. burgdorferi was dependent on reactive oxygen species (ROS) because cells from patients with chronic granulomatous disease, which are defective in ROS production, also produced elevated IL-1beta.	Reactive Oxygen Species	60-83	interleukin 1 beta	Homo sapiens	216-224
23386602-6	2013	Autophagy induction against B. burgdorferi was dependent on reactive oxygen species (ROS) because cells from patients with chronic granulomatous disease, which are defective in ROS production, also produced elevated IL-1beta.	Reactive Oxygen Species	85-88	interleukin 1 beta	Homo sapiens	216-224
23509960-7	2013	For the function-inducing responses, we measured inhibition of intracellular calcium release stimulated by the proinflammatory cytokine, interleukin (IL)-1beta.	Calcium	77-84	interleukin 1 beta	Homo sapiens	137-159
23348149-3	2013	However, with the treatment of a pro-inflammatory factor interleukin-1beta on the myofibroblasts, the effects of CTS on the myofibroblast were diminished.	castanospermine	113-116	interleukin 1 beta	Homo sapiens	57-74
23509960-9	2013	Responses measured include: phosphorylation of extracellular-signal-regulated kinases (pERK1/2) by Western blotting, Ki-67 immunolabeling for cell proliferation, IL-1beta-induced calcium release by ratiometric fluorescence, and cytokine/chemokine (IL-6, CXCL10) secretions by ELISA.	Calcium	179-186	interleukin 1 beta	Homo sapiens	162-170
23509960-11	2013	Repeated FTY720 dosing concurrently maintained a functional cell response as measured by the inhibition of intracellular calcium release when stimulated by the cytokine IL-1beta.	Calcium	121-128	interleukin 1 beta	Homo sapiens	169-177
23239492-0	2013	Titanium dioxide nanoparticles induce matrix metalloprotease 1 in human pulmonary fibroblasts partly via an interleukin-1beta-dependent mechanism.	titanium dioxide	0-16	interleukin 1 beta	Homo sapiens	108-125
23411072-1	2013	A series of novel 6-(aminomethylphenoxy)benzoxaborole analogs was synthesized for the investigation of the structure-activity relationship of the inhibition of TNF-alpha, IL-1beta, and IL-6, from lipopolysaccharide stimulated peripheral blood mononuclear cells.	6-(aminomethylphenoxy)benzoxaborole	18-53	interleukin 1 beta	Homo sapiens	171-179
23291534-11	2013	Particularly, the parent fraction AP-AU and its high-molecular weight sub-fraction AP-AU1 (average M(r) was estimated to be 39.5kDa) induced production of NO and cytokines [interleukin (IL)-1beta, -6, -10, tumor necrosis factor (TNF)-alpha, and granulocyte-macrophage-colony stimulating factor (GM-CSF)] in human peripheral blood mononuclear cells and human and murine monocyte/macrophages cell lines in vitro.	ap-au	34-39	interleukin 1 beta	Homo sapiens	173-204
23473301-3	2013	Compared to control hATSCs, the engraftment of GABA-hATSCs into animals with neuropathic pain significantly reduced secondary injury, including inflammation, GABAergic neuronal degeneration, and the circulation or propagation of proinflammatory factors cyclooxygenase2 (COX2), interlukin-1 beta (IL-1beta), NADPH oxidase 2 (NOX 2), NADPH oxidase 4 (NOX 4) and tumor necrosis factor alpha (TNFalpha) into the lesion.	gamma-Aminobutyric Acid	47-51	interleukin 1 beta	Homo sapiens	296-304
23239492-8	2013	MMP-1 induction by TiO2 NPs was not related to TGF-beta, oxidative stress, or EMPRIN expression but was related to IL-1beta expression, which partly drives MMP-1 induction by two TiO2 NPs (one anatase/rutile mix and the rutile one).	titanium dioxide	19-23	interleukin 1 beta	Homo sapiens	115-123
23239492-8	2013	MMP-1 induction by TiO2 NPs was not related to TGF-beta, oxidative stress, or EMPRIN expression but was related to IL-1beta expression, which partly drives MMP-1 induction by two TiO2 NPs (one anatase/rutile mix and the rutile one).	titanium dioxide	179-183	interleukin 1 beta	Homo sapiens	115-123
23179989-7	2013	There was also a trend of an increase in interleukin (IL)-6 in blood, ethane in exhaled air, and IL-1beta in EBC after exposure to cooking fumes.	NSC638702	109-112	interleukin 1 beta	Homo sapiens	97-105
23239492-9	2013	Taken together, our results show that TiO2 NPs are potent inducers and regulators of MMP-1 expression and activity, partly via an IL-1beta-dependent mechanism.	titanium dioxide	38-42	interleukin 1 beta	Homo sapiens	130-138
23179989-8	2013	In a sub-analysis of 12 subjects, there was also an increase in the levels of ethane--from 2.83 parts per billion (ppb) on the morning before exposure to cooking fumes to 3.53 ppb on the morning after exposure (P = 0.013)--and IL-1beta--from 1.04 on the morning before exposure to cooking fumes to 1.39 pg ml(-1) immediately after (P = 0.024).	Ethane	78-84	interleukin 1 beta	Homo sapiens	227-235
23072581-9	2013	Moreover, LPS-induced increase of cytokine production (TNF-alpha, IL-1beta) was inhibited by cilostazol, an effect which was accompanied by suppression of IkappaBalpha degradation, and NF-kappaB p65 nuclear translocation.	Cilostazol	93-103	interleukin 1 beta	Homo sapiens	66-74
23433788-3	2013	RESULTS: Using MTT and flow cytometry, IL-13, TNF-alpha and IL-1beta pretreatment decreased Fas-induced cell death.	monooxyethylene trimethylolpropane tristearate	15-18	interleukin 1 beta	Homo sapiens	60-68
23277324-4	2013	The well-known immunostimulatory peptide sequence derived from the human interleukin 1beta (IL-1beta), VQGEESNDK, was coupled on the NPs of 169 nm mean diameter in phosphate buffer (pH 8, 10 mM).	Phosphates	164-173	interleukin 1 beta	Homo sapiens	92-100
22571867-10	2013	Of four patients with paired data, three (including a responder to pranlukast) showed decreased pro-inflammatory cytokines (IL-1beta, IL-6, and TNFalpha), and four showed decreased sTNFR1, after pranlukast treatment, and only a responder had markedly decreased frequency of CD8+ T cells in CSF.	pranlukast	67-77	interleukin 1 beta	Homo sapiens	124-132
23397947-3	2013	In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes.	Niacinamide	38-50	interleukin 1 beta	Homo sapiens	151-173
23397947-3	2013	In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes.	Amides	45-50	interleukin 1 beta	Homo sapiens	151-173
23397947-3	2013	In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes.	Niacinamide	76-86	interleukin 1 beta	Homo sapiens	151-173
23314015-4	2013	RECENT FINDINGS: Recent studies support a role for CCA-induced interleukin-1beta (IL-1beta) signaling in the cause of CTRS.	1-methylcyclohexanecarboxylic acid	51-54	interleukin 1 beta	Homo sapiens	63-80
23433788-3	2013	RESULTS: Using MTT and flow cytometry, IL-13, TNF-alpha and IL-1beta pretreatment decreased Fas-induced cell death.	ammonium ferrous sulfate	92-95	interleukin 1 beta	Homo sapiens	60-68
23314015-4	2013	RECENT FINDINGS: Recent studies support a role for CCA-induced interleukin-1beta (IL-1beta) signaling in the cause of CTRS.	1-methylcyclohexanecarboxylic acid	51-54	interleukin 1 beta	Homo sapiens	82-90
23608554-8	2013	Decreased levels of TNF-alpha, IL-1beta and IL-17 were found in hydroxyurea-treated patients.	Hydroxyurea	64-75	interleukin 1 beta	Homo sapiens	31-39
23652186-9	2013	The IL-6 concentrations were associated with TAG, and IL-1beta with HDL-cholesterol concentration, after adjustment by BMI.	Cholesterol	72-83	interleukin 1 beta	Homo sapiens	54-62
22508334-10	2013	Pretreatment with 1,25(OH)2D3 (10 nM and 100 nM) significantly decreased the stimulatory effects of MC medium, TNFalpha and IL-1beta on MCP-1 expression and protein release, although the effect on stimulated release of IL-6 was less potent.	Calcitriol	18-29	interleukin 1 beta	Homo sapiens	124-132
23422489-0	2013	Re-evaluation of anti-inflammatory potential of eugenol in IL-1beta-stimulated gingival fibroblast and pulp cells.	Eugenol	48-55	interleukin 1 beta	Homo sapiens	59-67
23422489-2	2013	In the present study, we investigated the effect of eugenol on interleukin-8 (IL-8) production by IL-1beta-stimulated oral cells.	Eugenol	52-59	interleukin 1 beta	Homo sapiens	98-106
26785783-8	2013	The interleukin (IL)-1beta and IL-10 release by hMDMs was clearly increased upon stimulation with 1,25-dihydroxyvitamin D.	1,25-dihydroxyvitamin D	98-121	interleukin 1 beta	Homo sapiens	4-26
22367679-4	2013	AMCs respond vigorously to hypoxia by producing excess amounts of inflammatory cytokines e.g. the tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) along with glutamate, nitric oxide (NO) and reactive oxygen species which collectively cause oligodendrocyte death, axonal degeneration as well as disruption of the immature blood brain barrier.	amcs	0-4	interleukin 1 beta	Homo sapiens	142-159
22367679-4	2013	AMCs respond vigorously to hypoxia by producing excess amounts of inflammatory cytokines e.g. the tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) along with glutamate, nitric oxide (NO) and reactive oxygen species which collectively cause oligodendrocyte death, axonal degeneration as well as disruption of the immature blood brain barrier.	amcs	0-4	interleukin 1 beta	Homo sapiens	161-169
22367679-5	2013	A similar phenomenon is observed in the hypoxic developing cerebellum in which activated AMCs induced Purkinje neuronal death through production of TNF-alpha and IL-1beta via their respective receptors.	amcs	89-93	interleukin 1 beta	Homo sapiens	162-170
22367679-6	2013	Hypoxia is also implicated in retinopathy of prematurity in which activation of AMCs has been shown to cause retinal ganglion cell death through production of TNF-alpha and IL-1beta and NO.	amcs	80-84	interleukin 1 beta	Homo sapiens	173-181
23507225-10	2013	A positive correlation existed between IL-1beta and urinary 8-epi-PGF2alpha (r = 0.435, P &lt; .001) and between changes in IL-6 and urinary 8-epi-PGF2alpha (r = 0.393, P &lt; .001).	8-epi-prostaglandin F2alpha	60-75	interleukin 1 beta	Homo sapiens	39-47
23464634-7	2013	The present data show that mannose, a recently described inhibitor of hyaluronan synthesis, inhibits dermal fibroblast invasion and prevents the enhanced leukocyte binding to hyaluronan that takes place in cells treated with an inflammatory mediator interleukin-1beta.	Mannose	27-34	interleukin 1 beta	Homo sapiens	250-267
23464634-7	2013	The present data show that mannose, a recently described inhibitor of hyaluronan synthesis, inhibits dermal fibroblast invasion and prevents the enhanced leukocyte binding to hyaluronan that takes place in cells treated with an inflammatory mediator interleukin-1beta.	Hyaluronic Acid	175-185	interleukin 1 beta	Homo sapiens	250-267
23333395-5	2013	The effects of hypoxia on HIF-1alpha and IL-1beta were potentiated by 5.5 mM glucose, especially after 48 h (p&lt;0.05).	Glucose	77-84	interleukin 1 beta	Homo sapiens	41-49
23112137-3	2013	Here we show for the first time that citrate-stabilized gold nanoparticles, in a size dependent manner, specifically downregulate cellular responses induced by IL-1beta both in vitro and in vivo.	Citric Acid	37-44	interleukin 1 beta	Homo sapiens	160-168
22999910-0	2013	Rosuvastatin inhibits spontaneous and IL-1beta-induced interleukin-6 production from human cultured osteoblastic cells.	Rosuvastatin Calcium	0-12	interleukin 1 beta	Homo sapiens	38-46
22999910-8	2013	RESULTS: Rosuvastatin significantly reduced IL-6 levels in the osteoblast culture medium, both in unstimulated and IL-1beta-stimulated cells.	Rosuvastatin Calcium	9-21	interleukin 1 beta	Homo sapiens	115-123
22982753-5	2013	We show here that PGE2 blocks the production of IL-23 by LPS-stimulated monocytes in an IL-10 and IL-1beta independent manner.	Dinoprostone	18-22	interleukin 1 beta	Homo sapiens	98-106
23654106-5	2013	RESULTS: At 8h exposure to ZnO-NPs, there was no significant difference in the activity of LDH in the cell culture media among the ZnO-NPs-treated and control groups, but the activity of caspase-1 and the levels of IL-1beta in A549 cells were significantly increased in 20 microg/ml ZnO-NPs group compared to that in the control group (P &lt; 0.05).	Zinc Oxide	27-30	interleukin 1 beta	Homo sapiens	215-223
23654106-6	2013	Levels of IL-1beta and activity of LDH in the groups treated with ZnO-NPs (10 or 20 microg/ml) were significantly higher than that in the control group after 24 h exposure to ZnO-NPs, but there was no significant difference in the activity of caspase-1 among ZnO-NPs and control group.	Zinc Oxide	66-69	interleukin 1 beta	Homo sapiens	10-18
23654106-6	2013	Levels of IL-1beta and activity of LDH in the groups treated with ZnO-NPs (10 or 20 microg/ml) were significantly higher than that in the control group after 24 h exposure to ZnO-NPs, but there was no significant difference in the activity of caspase-1 among ZnO-NPs and control group.	Zinc Oxide	175-178	interleukin 1 beta	Homo sapiens	10-18
23654106-6	2013	Levels of IL-1beta and activity of LDH in the groups treated with ZnO-NPs (10 or 20 microg/ml) were significantly higher than that in the control group after 24 h exposure to ZnO-NPs, but there was no significant difference in the activity of caspase-1 among ZnO-NPs and control group.	Zinc Oxide	175-178	interleukin 1 beta	Homo sapiens	10-18
23266381-8	2013	Interestingly, DPC-333 was found to up-regulate mRNA expression of caspase-1 in hPBMC in a dose dependent fashion and selective caspase-1 inhibitor completely restored DPC-333 induced IL-1beta and IFN-gamma.	BMS561392	15-22	interleukin 1 beta	Homo sapiens	184-192
23266381-9	2013	Furthermore, selective IL-1beta receptor antagonist (anakinra) prevented DPC-333 induced IFN-gamma.	BMS561392	73-80	interleukin 1 beta	Homo sapiens	23-31
23315075-7	2013	Knocking down the NLRP3 or inhibiting caspase-1, ROS, and K(+) efflux decreased IL-1beta production.	Reactive Oxygen Species	49-52	interleukin 1 beta	Homo sapiens	80-88
23315075-9	2013	These findings provide new insights in lupus pathogenesis by demonstrating that self dsDNA together with its autoantibodies induces IL-1beta production from human monocytes by activating the NLRP3 inflammasome through inducing ROS synthesis and K(+) efflux, leading to the increased Th17 cell response.	Reactive Oxygen Species	227-230	interleukin 1 beta	Homo sapiens	132-140
23406982-9	2013	Furthermore, IL-1beta-induced upregulation of ADAMTS-4 was suppressed by overexpression of miR-125b in human OA chondrocytes.	mir-125b	91-99	interleukin 1 beta	Homo sapiens	13-21
23255592-3	2013	In inflamed HLMVEC (pretreated with interleukin-1beta and interferon-gamma), we found enhanced binding of eNOS to calcium-calmodulin at basal Ca(2+) levels, thereby increasing its basal activity that was dependent on extracellular l-Arg.	Arginine	231-236	interleukin 1 beta	Homo sapiens	36-53
22160241-8	2013	Significant associations for IL-1beta, IL-6 and adiponectin were observed with the PC1 score, BMI and triacylglycerol; these associations were higher with the PC1 score than with BMI and triacylglycerol.	Triglycerides	102-117	interleukin 1 beta	Homo sapiens	29-37
23384353-5	2013	The levels of interleukin (IL)-1beta, lipopolysaccharide-induced tumor necrosis factor-alpha and IL-6 in serum were significantly decreased by GABA at 80 mg/kg (P &lt; 0.05).	gamma-Aminobutyric Acid	143-147	interleukin 1 beta	Homo sapiens	14-36
23096219-1	2013	PURPOSE: The aim of the present study was to evaluate the effect of topical chamomile and corticosteroid treatment on the profile of tissue cytokines (IL-1beta and TNF-alpha) in 5-fluorouracil-induced oral mucositis in hamsters.	Fluorouracil	178-192	interleukin 1 beta	Homo sapiens	151-159
23096219-6	2013	The streptavidin-biotin complex method was used to delineate the in situ distribution, localization, and semiquantitative analysis of IL-1beta and TNF-alpha.	Biotin	17-23	interleukin 1 beta	Homo sapiens	134-142
22160241-8	2013	Significant associations for IL-1beta, IL-6 and adiponectin were observed with the PC1 score, BMI and triacylglycerol; these associations were higher with the PC1 score than with BMI and triacylglycerol.	Triglycerides	187-202	interleukin 1 beta	Homo sapiens	29-37
22740381-4	2013	Here, our findings demonstrate that LfcinB restored the proteoglycan loss promoted by catabolic factors (interleukin-1beta) IL-1beta and FGF-2 in vitro and ex vivo.	LFcinB	36-42	interleukin 1 beta	Homo sapiens	105-122
22653750-5	2013	Therefore, we compared the potency of 13 different glucan preparations to induce in vitro production of IL-1beta, IL-6, IL-8 and TNF-alpha in human, whole blood cultures.	Glucans	51-57	interleukin 1 beta	Homo sapiens	104-112
23335378-10	2013	On the other hand, paricalcitol therapy reduced IL-8, IL-1beta, and TNF-alpha.	paricalcitol	19-31	interleukin 1 beta	Homo sapiens	54-62
23335378-11	2013	CONCLUSIONS: These results further support the beneficial effects of vitamin D treatment in hemodialysis patients, since it strongly affects PAF/thrombin activities, PAF-metabolism, and IL-8, IL-1beta and TNF-alpha circulating levels.	Vitamin D	69-78	interleukin 1 beta	Homo sapiens	192-200
23347846-8	2013	RESULTS: Curcumin effectively blocked IL-1beta and PMA-induced IL-6 expression both in MH7A cells and RA-FLS.	Curcumin	9-17	interleukin 1 beta	Homo sapiens	38-46
23150523-7	2013	HIV(+) human macrophages treated with sulfated dehydroepiandrosterone (DHEA-S) showed suppression of inflammatory gene (IL-1beta, IL-6, TNF-alpha) expression.	Dehydroepiandrosterone	47-69	interleukin 1 beta	Homo sapiens	120-128
23150523-7	2013	HIV(+) human macrophages treated with sulfated dehydroepiandrosterone (DHEA-S) showed suppression of inflammatory gene (IL-1beta, IL-6, TNF-alpha) expression.	Dehydroepiandrosterone	71-77	interleukin 1 beta	Homo sapiens	120-128
23150523-9	2013	DHEA-S treatment reduced inflammatory gene transcripts (IL-1beta, TNF-alpha, CD3epsilon, GFAP) in brain compared to vehicle-(beta-cyclodextrin)-treated FIV(+) animals similar to levels found in vehicle-treated FIV(-) animals.	Dehydroepiandrosterone	0-6	interleukin 1 beta	Homo sapiens	56-64
23054852-8	2013	IL-1beta was significantly reduced after 24 h in dexamethasone group (290 vs 665 pg/ml).	Dexamethasone	49-62	interleukin 1 beta	Homo sapiens	0-8
23333629-3	2013	In the study, taraxerol concentration dependently inhibited nitric-oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein and mRNA levels and these inhibitions decreased the production of nitric oxide (NO), prostaglandin 2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta induced by LPS.	taraxerol	14-23	interleukin 1 beta	Homo sapiens	307-315
23250746-9	2013	This ceramide response augmented IL-1beta and TNFalpha release, a process that may contribute to the enhanced inflammatory response in metabolic diseases characterized by dyslipidemia.	Ceramides	5-13	interleukin 1 beta	Homo sapiens	33-41
22740381-4	2013	Here, our findings demonstrate that LfcinB restored the proteoglycan loss promoted by catabolic factors (interleukin-1beta) IL-1beta and FGF-2 in vitro and ex vivo.	LFcinB	36-42	interleukin 1 beta	Homo sapiens	124-132
22740381-5	2013	Mechanistically, LfcinB attenuated the effects of IL-1beta and FGF-2 on the expression of cartilage-degrading enzymes (MMP-1, MMP-3, and MMP-13), destructive cytokines (IL-1beta and IL-6), and inflammatory mediators (iNOS and TLR2).	LFcinB	17-23	interleukin 1 beta	Homo sapiens	50-58
22740381-5	2013	Mechanistically, LfcinB attenuated the effects of IL-1beta and FGF-2 on the expression of cartilage-degrading enzymes (MMP-1, MMP-3, and MMP-13), destructive cytokines (IL-1beta and IL-6), and inflammatory mediators (iNOS and TLR2).	LFcinB	17-23	interleukin 1 beta	Homo sapiens	169-177
22740381-8	2013	We also revealed that LfcinB exerted similar protective effects on human synovial fibroblasts challenged by IL-1beta, with minimal cytotoxicity.	LFcinB	22-28	interleukin 1 beta	Homo sapiens	108-116
23197771-7	2013	TAPI-0 suppressed LPS-induced inflammatory cell accumulation, total protein level elevation in BAL fluid, and production of inflammatory mediators, including tumor necrosis factor-alpha, interleukin-1beta, and macrophage inflammatory protein-2.	TAPI-0	0-6	interleukin 1 beta	Homo sapiens	187-204
22762165-1	2013	5-Arylidene-2-oxo-4-thiazolidinones and 2-phenylimino analogues were evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1beta and for their inhibitory capability against matrix metalloproteinase- 13.	5-arylidene-2-oxo-4-thiazolidinones	0-35	interleukin 1 beta	Homo sapiens	159-167
22762165-3	2013	Out of the selected compounds, (5-arylidene- 2,4-dioxothiazolidin-3-yl)acetic acids 7-9 showed significant effectiveness in reducing NO release and restoring normal levels of GAGs in chondrocytes treated with IL-1beta.	(5-arylidene- 2,4-dioxothiazolidin-3-yl)acetic acids	31-83	interleukin 1 beta	Homo sapiens	209-217
23139166-3	2013	Treatment with AH inhibited lipopolysaccharide (LPS)-induced interleukin-6, IL-1beta, inducible nitric oxide synthase, and cyclooxygenase-2 expression and nitric oxide production.	ah	15-17	interleukin 1 beta	Homo sapiens	76-84
23401297-6	2013	RESULTS AND CONCLUSION: IL-1beta inhibited insulin-induced activation of Akt phosphorylation, glucose transport, and fatty acid uptake.	Glucose	94-101	interleukin 1 beta	Homo sapiens	24-32
23401297-6	2013	RESULTS AND CONCLUSION: IL-1beta inhibited insulin-induced activation of Akt phosphorylation, glucose transport, and fatty acid uptake.	Fatty Acids	117-127	interleukin 1 beta	Homo sapiens	24-32
23353121-2	2013	The cytotoxic effects of these compounds along with the lead compound curcumin (7) and their effect on the production of the reactive oxygen species nitric oxide and pro-inflammatory cytokines IL-1beta, TNF-alpha and chemokine CXCL-8 were evaluated using human monocytic THP-1 and colon adenocarcinoma CACO-2 cell lines.	Curcumin	70-78	interleukin 1 beta	Homo sapiens	193-201
23219988-5	2013	The results showed that pretreatment with different doses of 3,5,4"-tri-O-acetylresveratrol improved seawater-induced lung histopathologic changes, alleviated lung edema, reduced the production of inflammatory mediators including TNF-alpha and IL-1beta, inhibited MDA activity, and enhanced T-SOD activity, which was possibly associated with inhibition of NF-kappaB and HIF-1alpha.	3,5,4'-tri-O-acetylresveratrol	61-91	interleukin 1 beta	Homo sapiens	244-252
23425281-10	2013	Hydrocortisone in combination with low-dose infliximab potentiated the suppressive effects on TNF-alpha, IL-1beta, IL-8, and macrophage inflammatory protein-1alpha synthesis.	Hydrocortisone	0-14	interleukin 1 beta	Homo sapiens	105-113
23136298-7	2013	Transfection of primary amnion cells with SIRT6 siRNA was associated with an increase in IL-1beta-induced proinflammatory cytokine gene expression and release (IL6, IL8, TNF [TNF-alpha]), cyclooxygenase ([COX]-2; official symbol PTGS2) expression and subsequent prostaglandin (PGE(2) and PGF(2alpha)) release, and MMP9 gene expression and release of pro-MMP9.	Prostaglandins	262-275	interleukin 1 beta	Homo sapiens	89-97
23136298-7	2013	Transfection of primary amnion cells with SIRT6 siRNA was associated with an increase in IL-1beta-induced proinflammatory cytokine gene expression and release (IL6, IL8, TNF [TNF-alpha]), cyclooxygenase ([COX]-2; official symbol PTGS2) expression and subsequent prostaglandin (PGE(2) and PGF(2alpha)) release, and MMP9 gene expression and release of pro-MMP9.	Prostaglandins E	277-280	interleukin 1 beta	Homo sapiens	89-97
23136298-7	2013	Transfection of primary amnion cells with SIRT6 siRNA was associated with an increase in IL-1beta-induced proinflammatory cytokine gene expression and release (IL6, IL8, TNF [TNF-alpha]), cyclooxygenase ([COX]-2; official symbol PTGS2) expression and subsequent prostaglandin (PGE(2) and PGF(2alpha)) release, and MMP9 gene expression and release of pro-MMP9.	Prostaglandins F	288-291	interleukin 1 beta	Homo sapiens	89-97
23159926-11	2013	Notably, exogenous ATP-elicited P2X7 activation and consequent IL-1beta release, an index of direct NLRP3 inflammasome activation, were not altered by statins.	Adenosine Triphosphate	19-22	interleukin 1 beta	Homo sapiens	63-71
23218372-4	2013	ELISA assay exhibited that chitosan inhibited the production of IL-1beta and TNF-alpha at 24, 48 and 72 h. IL-1beta and TNF-alpha secreted by HPDLCs with LPS and treated with 1000 mug/mL of HTCC significantly increased compared to both the control and the chitosan group (P&lt;0.001).	Chitosan	27-35	interleukin 1 beta	Homo sapiens	64-72
23218372-4	2013	ELISA assay exhibited that chitosan inhibited the production of IL-1beta and TNF-alpha at 24, 48 and 72 h. IL-1beta and TNF-alpha secreted by HPDLCs with LPS and treated with 1000 mug/mL of HTCC significantly increased compared to both the control and the chitosan group (P&lt;0.001).	Chitosan	27-35	interleukin 1 beta	Homo sapiens	107-115
23172226-2	2013	In an effort to identify mechanisms that regulate MLK3 activity in beta cells, we discovered that IL-1beta stimulates Lys-63-linked ubiquitination of MLK3 via a conserved, TRAF6-binding peptapeptide motif in the catalytic domain of the kinase.	Lysine	118-121	interleukin 1 beta	Homo sapiens	98-106
23211828-0	2013	IL-1beta triggered by peptidoglycan and lipopolysaccharide through TLR2/4 and ROS-NLRP3 inflammasome-dependent pathways is involved in ocular Behcet"s disease.	Reactive Oxygen Species	78-81	interleukin 1 beta	Homo sapiens	0-8
23268743-5	2013	In the TNF-alpha-induced 3T3-L1 adipocyte model, garcinol and pterostilbene significantly decreased the mRNA expression of COX-2, iNOS, IL-6, and IL-1beta and IL-6 secretion by suppressing phosphorylation of p-IkappaBalpha and p-p65.	garcinol	49-57	interleukin 1 beta	Homo sapiens	146-154
23268743-5	2013	In the TNF-alpha-induced 3T3-L1 adipocyte model, garcinol and pterostilbene significantly decreased the mRNA expression of COX-2, iNOS, IL-6, and IL-1beta and IL-6 secretion by suppressing phosphorylation of p-IkappaBalpha and p-p65.	pterostilbene	62-75	interleukin 1 beta	Homo sapiens	146-154
23277563-5	2013	The antitransformation effect of metformin can be bypassed by overexpression of Lin28B or IL1beta, downstream targets of NF-kappaB.	Metformin	33-42	interleukin 1 beta	Homo sapiens	90-97
23211828-9	2013	ROS activator and inhibitor significantly increased and decreased the production of IL-1beta, respectively.	Reactive Oxygen Species	0-3	interleukin 1 beta	Homo sapiens	84-92
23211828-14	2013	Interaction of TLR2/4 with their ligands PGN/LPS is involved in BD pathogenesis, possibly by the induction of IL-1beta through a ROS-NLRP3-dependent pathway.	Reactive Oxygen Species	129-132	interleukin 1 beta	Homo sapiens	110-118
23211828-12	2013	Both SB203580 (p38 inhibitor) and PD98059 (ERK1/2 inhibitor) significantly decreased the production of IL-1beta.	SB 203580	5-13	interleukin 1 beta	Homo sapiens	103-111
23211828-12	2013	Both SB203580 (p38 inhibitor) and PD98059 (ERK1/2 inhibitor) significantly decreased the production of IL-1beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	34-41	interleukin 1 beta	Homo sapiens	103-111
23335921-9	2012	Phagocytosis of aluminum adjuvants followed by disruption of the phagolysosome activates NLRP3-inflammasomes resulting in the release of active IL-1beta and IL-18.	aluminum adjuvants	16-34	interleukin 1 beta	Homo sapiens	144-152
23229544-6	2013	Knockdown of DUSP14 increased basal as well as TNF- and IL-1-induced TAK1 phosphorylation at Thr-187.	Threonine	93-96	interleukin 1 beta	Homo sapiens	56-60
23229544-8	2013	These findings suggest that DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation by dephosphorylating TAK1 at Thr-187.	Threonine	127-130	interleukin 1 beta	Homo sapiens	64-68
23183108-5	2013	In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFalpha, IL-1beta, and IL-6 at low concentrations (LPS/TNFalpha, IC(50)=0.45n M; PHA/TNFalpha, IC(50)=0.40 nM).	6-(2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidin-3-yl)-2-(2-methylphenyl)pyridazin-3(2H)-one	45-54	interleukin 1 beta	Homo sapiens	190-198
23316199-6	2012	We will focus on the role of autocrine or paracrine ATP export in particle-induced NLRP3 inflammasome activation and discuss how particle activators are competent to induce maturation and secretion of IL-1beta through a process that involves, as a first event, extracellular release of endogenous ATP through hemichannel opening, and as a second event, signaling through purinergic receptors that trigger NLRP3 inflammasome activation.	Adenosine Triphosphate	297-300	interleukin 1 beta	Homo sapiens	201-209
23221073-11	2013	Lysosomal destabilization induced by Leu-Leu-OMe triggered caspase-1 activation, IL-1beta secretion, and ARPE-19 cell death.	leucyl-leucine-methyl ester	37-48	interleukin 1 beta	Homo sapiens	81-89
23221073-12	2013	Blocking Leu-Leu-OMe-induced lysosomal disruption with the compound Gly-Phe-CHN(2) or inhibiting caspase-1 with Z-YVAD-FMK abrogated IL-1beta release and ARPE-19 cytotoxicity.	leucyl-leucine-methyl ester	9-20	interleukin 1 beta	Homo sapiens	133-141
23183108-6	2013	In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFalpha- and IL-1 beta-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells.	6-(2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidin-3-yl)-2-(2-methylphenyl)pyridazin-3(2H)-one	42-51	interleukin 1 beta	Homo sapiens	116-125
23221073-12	2013	Blocking Leu-Leu-OMe-induced lysosomal disruption with the compound Gly-Phe-CHN(2) or inhibiting caspase-1 with Z-YVAD-FMK abrogated IL-1beta release and ARPE-19 cytotoxicity.	gly-phe-chn	68-79	interleukin 1 beta	Homo sapiens	133-141
23183108-6	2013	In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFalpha- and IL-1 beta-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells.	Prostaglandins E	154-157	interleukin 1 beta	Homo sapiens	116-125
23221073-12	2013	Blocking Leu-Leu-OMe-induced lysosomal disruption with the compound Gly-Phe-CHN(2) or inhibiting caspase-1 with Z-YVAD-FMK abrogated IL-1beta release and ARPE-19 cytotoxicity.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	112-122	interleukin 1 beta	Homo sapiens	133-141
23610962-5	2013	IP6 had suppressive effect on basal and IL-1beta-stimulated IL-8 secretion by cells.	Phytic Acid	0-3	interleukin 1 beta	Homo sapiens	40-48
23610962-8	2013	In addition, total PTK activity in both unstimulated and IL-1beta stimulated cells was determined in the presence of IP6.	Phytic Acid	117-120	interleukin 1 beta	Homo sapiens	57-65
24106709-6	2013	Individuals without implant showed higher cytokine response to Ti materials than individuals with symptom-free implants; for example, TiO2 rutile particle induced increase of IL-1 beta 70.27-fold/8.49-fold versus control medium culture.	titanium dioxide	134-138	interleukin 1 beta	Homo sapiens	175-184
24158104-9	2013	Furthermore, cultured human MC showed increased ACE2 mRNA and protein after treatment with IL-1beta, a pro-inflammatory cytokine in IgAN.	Methylcholanthrene	28-30	interleukin 1 beta	Homo sapiens	91-99
24351550-6	2013	In normal human chondrocytes, CHOP "gain of function" sensitized chondrocytes to IL-1beta induced nitric oxide (NO) and matrix metalloproteinase (MMP)-3 release without inducing these responses by itself.	Nitric Oxide	98-110	interleukin 1 beta	Homo sapiens	81-89
23484196-0	2013	Production of early IL-1beta induced by human serum gamma-globulin metal complexes.	Metals	67-72	interleukin 1 beta	Homo sapiens	20-28
23484124-6	2013	By comparison, exposure to dexamethasone reduced TNF- alpha , IL-6, and IL-1 beta production, while at this time point it increased resistin protein secretion.	Dexamethasone	27-40	interleukin 1 beta	Homo sapiens	72-81
23509682-7	2013	ROS formation seems important for PM10-induced IL-1beta response, but further investigations are needed to elucidate the molecular pathway by which this effect is mediated.	ros	0-3	interleukin 1 beta	Homo sapiens	47-55
23839108-8	2013	EGCG prevented IL-1beta/ IL-4 or TNF-alpha/IL-4-mediated CCL11 production in a concentration dependent manner.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	15-23
23839108-10	2013	Western blot analysis revealed that EGCG treatment prevented IL-1beta/IL-4 or TNF-alpha/IL-4-induced ERK and JNK activation in HGFs.	epigallocatechin gallate	36-40	interleukin 1 beta	Homo sapiens	61-69
24247107-6	2013	Concerning proinflammatory signaling pathways, IL1beta emerged as a powerful inducer of matrix turnover, since it significantly enhanced PIIINP, TIMP-1 and hyaluronic acid production and increased metalloproteinase activity.	Hyaluronic Acid	156-171	interleukin 1 beta	Homo sapiens	47-54
22763852-5	2013	NaB significantly inhibited the LPS-induced production of reactive oxygen species and the expression of pro-inflammatory cytokines (IL-1beta and TNF-alpha).	nab	0-3	interleukin 1 beta	Homo sapiens	132-140
22847551-5	2013	With increasing concentrations of IL-1beta and TNF-alpha (0.01-1 ng/ml), an increase in both intracellular and extracellular GSH levels was observed, followed by a return to control levels in response to higher concentrations of IL-1beta and TNF-alpha.	Glutathione	125-128	interleukin 1 beta	Homo sapiens	34-42
22847551-6	2013	Extracellular levels of cysteinylglycine decreased in response to all concentrations of IL-1beta and TNF-alpha.	cysteinylglycine	24-40	interleukin 1 beta	Homo sapiens	88-96
22847551-7	2013	In contrast, levels of the neurotoxic thiol homocysteine increased in a dose-dependent manner to IL-1beta and TNF-alpha-induced activation.	thiol homocysteine	38-56	interleukin 1 beta	Homo sapiens	97-105
23430672-12	2013	However, levels of IL-1beta, IL6, and IL10 in tears were significantly lower in the DEDG+S versus the DEDG-NS and in the CG+S versus the CG-NS.	Sulfur	89-90	interleukin 1 beta	Homo sapiens	19-27
23484196-1	2013	Plasma gamma-globulin fraction proteins, copper and zinc cations, and metal complexes formed by them with human serum gamma-globulin induce the production of early (24-h incubation) IL-1beta by human blood cells.	Copper	41-47	interleukin 1 beta	Homo sapiens	182-190
23484196-1	2013	Plasma gamma-globulin fraction proteins, copper and zinc cations, and metal complexes formed by them with human serum gamma-globulin induce the production of early (24-h incubation) IL-1beta by human blood cells.	Metals	70-75	interleukin 1 beta	Homo sapiens	182-190
23484196-2	2013	The protein modified by Zn cations 1.2 times more actively (p&lt;0.01) induced early IL-1beta than the control gamma-globulin, while gamma-globulin metal complex with copper was 1.4 times less active (p&lt;0.1) than the control protein.	Zinc	24-26	interleukin 1 beta	Homo sapiens	85-93
23103122-5	2013	Therefore, the aim of the present study was to investigate calcitriol effects upon TNF-alpha, IFN-gamma, IL-6 and IL-1beta in cultured placental cells from preeclamptic women by using qPCR and ELISA.	Calcitriol	59-69	interleukin 1 beta	Homo sapiens	114-122
23237500-0	2013	Incomplete elongation of the chondroitin sulfate linkage region on aggrecan and response to interleukin-1beta.	Chondroitin Sulfates	29-48	interleukin 1 beta	Homo sapiens	92-109
23237500-6	2013	The total mole fraction of unelongated xylose residues per aggrecan was significantly less (p = 0.03) after IL-1beta treatment compared to control cultures, with unelongated xylose residues constituting between 6% and 12% of the fraction of total CS measured.	Xylose	39-45	interleukin 1 beta	Homo sapiens	108-116
24016270-7	2013	FACS was used to screen hIL- 1beta-binding clones with FITC-labeled hIL-1beta protein.	Fluorescein-5-isothiocyanate	55-59	interleukin 1 beta	Homo sapiens	24-34
24016270-7	2013	FACS was used to screen hIL- 1beta-binding clones with FITC-labeled hIL-1beta protein.	Fluorescein-5-isothiocyanate	55-59	interleukin 1 beta	Homo sapiens	68-77
24016270-17	2013	The MTT test suggests that scFv-20 is a neutralization antibody against hIL-1beta.	monooxyethylene trimethylolpropane tristearate	4-7	interleukin 1 beta	Homo sapiens	72-81
23086037-4	2013	Upregulated interleukin (IL)-1beta maturation, IL-18 secretion, and caspase-1 cleavage were observed in MDMs from type 2 diabetic patients after stimulation with various danger molecules (ATP, high-mobility group protein B1, free fatty acids, islet amyloid polypeptide, and monosodium uric acid crystals).	Adenosine Triphosphate	188-191	interleukin 1 beta	Homo sapiens	12-34
23086037-4	2013	Upregulated interleukin (IL)-1beta maturation, IL-18 secretion, and caspase-1 cleavage were observed in MDMs from type 2 diabetic patients after stimulation with various danger molecules (ATP, high-mobility group protein B1, free fatty acids, islet amyloid polypeptide, and monosodium uric acid crystals).	Fatty Acids, Nonesterified	225-241	interleukin 1 beta	Homo sapiens	12-34
23086037-4	2013	Upregulated interleukin (IL)-1beta maturation, IL-18 secretion, and caspase-1 cleavage were observed in MDMs from type 2 diabetic patients after stimulation with various danger molecules (ATP, high-mobility group protein B1, free fatty acids, islet amyloid polypeptide, and monosodium uric acid crystals).	monosodium uric acid	274-294	interleukin 1 beta	Homo sapiens	12-34
23086037-5	2013	Mitochondrial reactive oxygen species and NLRP3 were required for IL-1beta synthesis in MDMs.	Reactive Oxygen Species	14-37	interleukin 1 beta	Homo sapiens	66-74
23086037-6	2013	Finally, 2 months of therapy with the antidiabetic drug metformin significantly inhibited the maturation of IL-1beta in MDMs from patients with type 2 diabetes through AMP-activated protein kinase (AMPK) activation.	Metformin	56-65	interleukin 1 beta	Homo sapiens	108-116
23076801-3	2013	We report that simvastatin inhibits IL-1beta, IL-23, TGF-beta, IL-21, IL-12p70, and induces IL-27 secretion from DCs in RRMS patients, providing an inhibitory cytokine milieu for Th17 and Th1-cell differentiation.	Simvastatin	15-26	interleukin 1 beta	Homo sapiens	36-44
24348674-0	2013	Modulatory effect of 1,25-dihydroxyvitamin D 3 on IL1 beta -induced RANKL, OPG, TNF alpha , and IL-6 expression in human rheumatoid synoviocyte MH7A.	1,25-dihydroxyvitamin D	21-44	interleukin 1 beta	Homo sapiens	50-58
24348674-4	2013	MH7A cells were stimulated with IL1 beta and then treated with different concentrations of 1,25(OH)2D3 for 48 h. A significantly elevated OPG/RANKL ratio and markedly decreased levels of IL-6 and TNF beta mRNA expression in cells and IL-6 protein in supernatants were observed in IL1 beta -induced MH7A in the presence of 1,25(OH)2D3 compared with those in the absence of it.	mh7a	0-4	interleukin 1 beta	Homo sapiens	32-40
24348674-4	2013	MH7A cells were stimulated with IL1 beta and then treated with different concentrations of 1,25(OH)2D3 for 48 h. A significantly elevated OPG/RANKL ratio and markedly decreased levels of IL-6 and TNF beta mRNA expression in cells and IL-6 protein in supernatants were observed in IL1 beta -induced MH7A in the presence of 1,25(OH)2D3 compared with those in the absence of it.	mh7a	0-4	interleukin 1 beta	Homo sapiens	280-288
24348674-4	2013	MH7A cells were stimulated with IL1 beta and then treated with different concentrations of 1,25(OH)2D3 for 48 h. A significantly elevated OPG/RANKL ratio and markedly decreased levels of IL-6 and TNF beta mRNA expression in cells and IL-6 protein in supernatants were observed in IL1 beta -induced MH7A in the presence of 1,25(OH)2D3 compared with those in the absence of it.	Calcitriol	91-102	interleukin 1 beta	Homo sapiens	280-288
23843863-13	2013	Of particular note, the protective effect of S-[6]-gingerol against the IL1beta-induced inflammatory response was similar to that of BHT, an ROS scavenger.	gingerol	45-59	interleukin 1 beta	Homo sapiens	72-79
23377818-8	2013	A positive correlation was detected between serum levels of 17-OHP and IL-1 beta in FMF patients (p = 0.006; r = 0.486).	17-alpha-Hydroxyprogesterone	60-66	interleukin 1 beta	Homo sapiens	71-80
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	gingerol	0-14	interleukin 1 beta	Homo sapiens	26-33
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	gingerol	44-58	interleukin 1 beta	Homo sapiens	87-94
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	ros	188-191	interleukin 1 beta	Homo sapiens	26-33
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	ros	150-153	interleukin 1 beta	Homo sapiens	87-94
23843863-10	2013	In addition, S-[6]-gingerol reduced IL1beta-induced COX2 upregulation as well as NF kappa B activity.	gingerol	13-27	interleukin 1 beta	Homo sapiens	36-43
24858561-0	2013	Elevated interleukin-1beta serum level after chronic peripheral salsolinol administration.	salsolinol	64-74	interleukin 1 beta	Homo sapiens	9-26
22990668-8	2013	RESULTS: Treatment of RA FLS with GW3965 induced dose-dependent reductions in mRNA expression of pro-inflammatory mediators (IL-1beta, IL-6, MMP-9, CCL-2, CCL-7, and COX-2).	GW 3965	34-40	interleukin 1 beta	Homo sapiens	125-133
23610862-11	2013	The association of allele 2 frequency and higher percentage of BOP sites in chronic periodontitis suggest that IL-1beta (+3954) potentially play a significant but not major role in the clinical outcome.	bop	63-66	interleukin 1 beta	Homo sapiens	111-119
24024773-9	2013	RESULTS: Vitamin A treatment significantly reduced serum concentrations of IL-1beta in obese vitamin A-treated subjects (from 3.58 +- 0.36 to 2.45 +- 0.23 pg/ml, p &lt; 0.006).	Vitamin A	9-18	interleukin 1 beta	Homo sapiens	75-83
24024773-9	2013	RESULTS: Vitamin A treatment significantly reduced serum concentrations of IL-1beta in obese vitamin A-treated subjects (from 3.58 +- 0.36 to 2.45 +- 0.23 pg/ml, p &lt; 0.006).	Vitamin A	93-102	interleukin 1 beta	Homo sapiens	75-83
24024773-11	2013	A significant reduction in IL-1beta/IL-4 ratio in the obese vitamin A-treated group was also observed (p = 0.03).	Vitamin A	60-69	interleukin 1 beta	Homo sapiens	27-35
24024773-12	2013	CONCLUSIONS: Decline in serum concentrations of IL-1beta and IL-1beta/IL-4 ratio in obese women suggests that vitamin A is capable of regulating the immune system and possibly reducing the risk of autoimmune disease in this group.	Vitamin A	110-119	interleukin 1 beta	Homo sapiens	48-56
24024773-12	2013	CONCLUSIONS: Decline in serum concentrations of IL-1beta and IL-1beta/IL-4 ratio in obese women suggests that vitamin A is capable of regulating the immune system and possibly reducing the risk of autoimmune disease in this group.	Vitamin A	110-119	interleukin 1 beta	Homo sapiens	61-69
24159421-7	2013	However, in response to anti-CD3/28 stimulation, simvastatin significantly upregulated IL-1beta production (P &lt; 0.05).	Simvastatin	49-60	interleukin 1 beta	Homo sapiens	87-95
24148794-9	2013	Moreover, H2 treatment dose-dependently attenuated the increased levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta, HMGB1), but further increased the level of anti-inflammatory cytokine IL-10 at 3 h, 6 h, 12 h and 24 h after LPS stimulation.	Hydrogen	10-12	interleukin 1 beta	Homo sapiens	114-122
23186989-7	2013	In the PBMCs/macrophages of both groups, soluble Abeta (sAbeta) increased the transcription/secretion of cytokines (e.g., IL1 and IL6) and chemokines (e.g., CCLs and CXCLs) and 1,25D3/RvD1 reversed most of the sAbeta effects.	sabeta	56-62	interleukin 1 beta	Homo sapiens	122-125
22933241-7	2013	Phagocytosis of PMMA particles induces caspase-1 dependent release of IL-1beta from human monocytes and mouse macrophages.	Polymethyl Methacrylate	16-20	interleukin 1 beta	Homo sapiens	70-78
24477249-7	2013	MLRA showed that gamma-GTP activity showed trends for higher IL-1beta concentrations after adjusting for age, BMI, energy intake, alcohol intake, and smoking status.	Alcohols	130-137	interleukin 1 beta	Homo sapiens	61-69
23319019-1	2013	It has been recently demonstrated that interleukin 1beta (IL-1beta) plays a central role in monosodium urate crystal-induced inflammation and that the NALP3 inflammasome plays a major role in IL-1beta production.	Uric Acid	92-108	interleukin 1 beta	Homo sapiens	39-56
23319019-1	2013	It has been recently demonstrated that interleukin 1beta (IL-1beta) plays a central role in monosodium urate crystal-induced inflammation and that the NALP3 inflammasome plays a major role in IL-1beta production.	Uric Acid	92-108	interleukin 1 beta	Homo sapiens	58-66
22683080-8	2013	DEX at 10 and 100ng/mL significantly inhibited the release of nitric oxide, prostaglandin E(2), interleukin 1beta, and tumor necrosis factor alpha and the expression of inducible nitric oxide synthase messenger RNA.	Dexmedetomidine	0-3	interleukin 1 beta	Homo sapiens	96-113
22546942-8	2013	Levels of IL-1beta in GCF were significantly reduced in SRP + PT and SRP + rPT groups compared with the SRP group (p &lt; 0.05).	L-seryl-AMP	56-59	interleukin 1 beta	Homo sapiens	10-18
24078775-0	2013	Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha via a NF-kappaB-dependent mechanism in HaCaT keratinocytes.	Palmitic Acid	0-13	interleukin 1 beta	Homo sapiens	77-94
23785824-2	2013	It is shown that one of the earliest and most sensitive indicators of the formation of the resistance of the organism employed in the manufacture of vinyl chloride, are: IgM, IL-1beta, TNF-alpha, autoantibodies to neurospecific proteins (S-100, Vd-Ca channels and DNA).	Vinyl Chloride	149-163	interleukin 1 beta	Homo sapiens	175-183
24078775-4	2013	Our results showed that palmitic acid induced an upregulation of IL-6, TNF- alpha , IL-1 beta secretions, accompanied by NF- kappa B nuclear translocation and activation.	Palmitic Acid	24-37	interleukin 1 beta	Homo sapiens	84-93
24078775-6	2013	Palmitic acid-induced IL-6, TNF- alpha , IL-1 beta productions were attenuated by NF- kappa B inhibitor PDTC.	Palmitic Acid	0-13	interleukin 1 beta	Homo sapiens	41-50
24078775-8	2013	These data demonstrate for the first time that palmitic acid can stimulate IL-6, TNF- alpha , IL-1 beta productions in HaCaT keratinocytes and cell proliferation, thereby potentially contributing to acne inflammation and pilosebaceous duct hyperkeratinization.	Palmitic Acid	47-60	interleukin 1 beta	Homo sapiens	94-103
22841520-5	2013	RESULTS: Compared to placebo, metformin reduced monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, monocyte chemoattractant protein-1 and interleukin-8, as well as decreased plasma C-reactive protein levels, which were accompanied by an improvement in insulin sensitivity.	Metformin	30-39	interleukin 1 beta	Homo sapiens	97-114
23852607-1	2013	Sterile particulates such as monosodium urate crystals induce inflammasome activation resulting in activation of caspase-1, secretion of IL-1alpha, and processing of IL-1beta.	Uric Acid	29-45	interleukin 1 beta	Homo sapiens	166-174
25224887-9	2013	For example, peripheral infection increases circulating IL-1beta that induces production of prostaglandins and IL-1beta by CNS immune cells that initiate fever and the behavioral symptoms of sickness.	Prostaglandins	92-106	interleukin 1 beta	Homo sapiens	56-64
23054013-3	2013	The polysaccharide obtained from these bacteria induces the expression of interleukin (IL)-1 beta, tumor necrosis factor, and IL-6.	Polysaccharides	4-18	interleukin 1 beta	Homo sapiens	74-97
24352507-5	2013	In the setting of the lack of IL-1beta responses after previous exposure to LPS, adenosine can supersede this tolerogenic state and drive IL-1beta production.	Adenosine	81-90	interleukin 1 beta	Homo sapiens	138-146
23690673-3	2013	We observed that heme in a concentration range found during hemolytic episodes (3-30 muM) elicits AM to present a proinflammatory profile, stimulating reactive oxygen species (ROS) and nitric oxide (NO) generation and inducing IL-1beta, IL-6, and IL-10 secretion.	Heme	17-21	interleukin 1 beta	Homo sapiens	227-235
23840918-8	2013	Luteolin and kaempferol decreased IL-1beta-induced NF-kappaB p65 DNA binding activity and nuclear c-Jun expression.	kaempferol	13-23	interleukin 1 beta	Homo sapiens	34-42
23182920-9	2013	Bilirubin increased basal production of IL-8 and IL-1beta, but downregulated LPS-induced generation of IL-8 and MIP-1beta.	Bilirubin	0-9	interleukin 1 beta	Homo sapiens	49-57
24352507-2	2013	Inflammasome activation is dependent on stimuli such as lipopolysaccharide (LPS) and ATP that provide two distinct signals resulting in rapid production of interleukin (IL)-1beta, with the lack of response to repeat stimulation.	Adenosine Triphosphate	85-88	interleukin 1 beta	Homo sapiens	156-178
23076270-10	2013	CONCLUSION: This study showed that splenic F-FDG uptake is related to IL-1beta, IL-1receptor antagonist, IL-4, IL-6, IL-7, and IL-13.	f-fdg	43-48	interleukin 1 beta	Homo sapiens	70-78
23840918-7	2013	Luteolin and kaempferol significantly reduced LPS-induced secretion of proinflammatory cytokines (IL-6 and IL-8) and prostaglandins (PGE(2) and PGF(2alpha)) in fetal membranes, IL-1beta-induced COX-2 gene expression and prostaglandin production in myometrium, and IL-1beta-induced MMP-9 activity in amnion and myometrial cells.	kaempferol	13-23	interleukin 1 beta	Homo sapiens	177-185
23840918-7	2013	Luteolin and kaempferol significantly reduced LPS-induced secretion of proinflammatory cytokines (IL-6 and IL-8) and prostaglandins (PGE(2) and PGF(2alpha)) in fetal membranes, IL-1beta-induced COX-2 gene expression and prostaglandin production in myometrium, and IL-1beta-induced MMP-9 activity in amnion and myometrial cells.	kaempferol	13-23	interleukin 1 beta	Homo sapiens	264-272
23844276-6	2013	Arachidonic acid and saturated fatty acids (SFAs) both demonstrate an ability to increase pro-inflammatory IL-8 along with numerous other inflammatory factors including IL-6, TNF alpha , IL-1 beta , and CXCL1 for arachidonic acid and IGB2 and CTSS for SFA.	Fatty Acids	21-42	interleukin 1 beta	Homo sapiens	187-196
23220033-9	2013	Results demonstrated that NG+IL-1beta and, to a greater extent, HG+IL-1beta significantly increased FITC-dextran diffusion, paralleled by decreased TEER.	fitc-dextran	100-112	interleukin 1 beta	Homo sapiens	29-37
23220033-9	2013	Results demonstrated that NG+IL-1beta and, to a greater extent, HG+IL-1beta significantly increased FITC-dextran diffusion, paralleled by decreased TEER.	fitc-dextran	100-112	interleukin 1 beta	Homo sapiens	67-75
23516573-5	2013	Exposure of IL-1beta-stimulated chondrocytes to the hexosamine analogs resulted in increased expression of ECM molecules and a corresponding improvement in cartilage-specific ECM accumulation.	Hexosamines	52-62	interleukin 1 beta	Homo sapiens	12-20
24399727-6	2013	RESULTS: Metformin treatment reduced plasma C-reactive protein levels and monocyte release of tumor necrosis factor-alpha and interleukin-6, as well as tended to reduce monocyte release of interleukin-1beta and monocyte chemoattractant protein-1, which was accompanied by an improvement in insulin sensitivity.	Metformin	9-18	interleukin 1 beta	Homo sapiens	189-206
23516523-7	2013	In addition, miR-181a mimics significantly inhibited increase in the levels of inflammatory factors (IL1b, IL6, and TNFa) in these cells.	mir-181a	13-21	interleukin 1 beta	Homo sapiens	101-105
23483986-11	2013	Combination of VTX-294 and MPLA induced greater blood TNF and IL-1beta responses than combination of R-848 and MPLA.	VTX-294	15-22	interleukin 1 beta	Homo sapiens	62-70
23483986-11	2013	Combination of VTX-294 and MPLA induced greater blood TNF and IL-1beta responses than combination of R-848 and MPLA.	monophosphoryl lipid A	27-31	interleukin 1 beta	Homo sapiens	62-70
23516573-8	2013	These studies established the disease modification potential of a hexosamine analog platform on IL-1beta-stimulated chondrocytes.	Hexosamines	66-76	interleukin 1 beta	Homo sapiens	96-104
23349769-2	2013	Using human pulmonary A549 cells, we showed that 34 out of 39 IL-1beta-inducible mRNAs were repressed to varying degrees by the synthetic glucocorticoid, dexamethasone.	Dexamethasone	154-167	interleukin 1 beta	Homo sapiens	62-70
23451225-2	2013	We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1beta and/or TNF-alpha, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively.	Iron	186-190	interleukin 1 beta	Homo sapiens	88-96
23451225-2	2013	We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1beta and/or TNF-alpha, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively.	Iron	306-310	interleukin 1 beta	Homo sapiens	88-96
23383347-0	2013	Epidermal growth factor protects squamous cell carcinoma against cisplatin-induced cytotoxicity through increased interleukin-1beta expression.	Cisplatin	65-74	interleukin 1 beta	Homo sapiens	114-131
23383347-6	2013	The involvement of Akt and NF-kappaB signaling pathways in the EGF-induced IL-1beta gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-kappaB inhibitors, LY294002 and parthenolide, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	interleukin 1 beta	Homo sapiens	75-83
23383347-6	2013	The involvement of Akt and NF-kappaB signaling pathways in the EGF-induced IL-1beta gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-kappaB inhibitors, LY294002 and parthenolide, respectively.	parthenolide	218-230	interleukin 1 beta	Homo sapiens	75-83
23383347-10	2013	The expression and secretion of IL-1beta induced by EGF considerably reduced chemotherapeutic drug cisplatin-induced cell death.	Cisplatin	99-108	interleukin 1 beta	Homo sapiens	32-40
23460908-11	2013	IL-1beta mediated its inhibitory effects on RBP4 expression via IL-1 receptor and NF-kappaB, as incubation with the IL-1 receptor blocking antibody and the NF-kappaB inhibitors CAPE and SC-514 reversed its effect.	SC 514	186-192	interleukin 1 beta	Homo sapiens	0-8
23382974-3	2013	Adenosine triphosphate (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically induced expression of IL-23 and IL-1beta from cultured monocytes as determined by ELISA assays.	Adenosine Triphosphate	0-22	interleukin 1 beta	Homo sapiens	137-145
23382974-3	2013	Adenosine triphosphate (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically induced expression of IL-23 and IL-1beta from cultured monocytes as determined by ELISA assays.	Adenosine Triphosphate	24-27	interleukin 1 beta	Homo sapiens	137-145
23382974-3	2013	Adenosine triphosphate (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically induced expression of IL-23 and IL-1beta from cultured monocytes as determined by ELISA assays.	lipoteichoic acid	49-66	interleukin 1 beta	Homo sapiens	137-145
23382974-3	2013	Adenosine triphosphate (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically induced expression of IL-23 and IL-1beta from cultured monocytes as determined by ELISA assays.	lipoteichoic acid	68-71	interleukin 1 beta	Homo sapiens	137-145
23382974-8	2013	Collectively, our data suggest TLR2 ligands encountered by innate immune cells in an environment with physiologically-relevant levels of extracellular ATP can induce a distinct activation state favoring IL-23- and IL-1beta-dependent Th17 type response.	Adenosine Triphosphate	151-154	interleukin 1 beta	Homo sapiens	214-222
23349769-6	2013	However, cycloheximide reduced the IL-1beta-dependent expression of 13 mRNAs, which, along with the 5 not showing repression by dexamethasone, were not analysed further.	Cycloheximide	9-22	interleukin 1 beta	Homo sapiens	35-43
23143065-4	2013	A cyclic AMP analog that specifically activates Epac, 8-(4-methoxyphenylthio)-2"-O-methyladenosine-3",5"-cyclic monophosphate (OPTmecAMP), and overexpression of liver-specific Epac2 both inhibited interleukin 1beta/interferon gamma-induced iNOS expression and nitrite production.	Cyclic AMP	2-12	interleukin 1 beta	Homo sapiens	197-214
23326479-8	2013	RESULTS: DON induced a pro-inflammatory response with a significant increase of expression of mRNA encoding for IL-8, IL-1alpha and IL-1beta, TNF-alpha in all used models.	deoxynivalenol	9-12	interleukin 1 beta	Homo sapiens	132-140
23326479-9	2013	Additionally, DON significantly induced the expression of genes involved in the differentiation of Th17 cells (STAT3, IL-17A, IL-6, IL-1beta) at the expenses of the pathway of regulatory T cells (Treg) (FoxP3, RALDH1).	deoxynivalenol	14-17	interleukin 1 beta	Homo sapiens	132-140
23633957-10	2013	HCV uptake concomitantly induces a potassium efflux that activates the NLRP3 inflammasome for IL-1beta processing and secretion.	Potassium	35-44	interleukin 1 beta	Homo sapiens	94-102
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	isoliquiritigenin	0-17	interleukin 1 beta	Homo sapiens	120-128
23874021-7	2013	Canakinumab is a human monoclonal antibody that selectively neutralizes IL-1beta, a pro-inflammatory cytokine that plays multiple roles in the atherothrombotic process and that undergoes activation by the NLRP3 inflammasome, a process promoted by cholesterol crystals that in turn leads directly to increased production of IL-1 and IL-6.	Cholesterol	247-258	interleukin 1 beta	Homo sapiens	72-80
23874021-7	2013	Canakinumab is a human monoclonal antibody that selectively neutralizes IL-1beta, a pro-inflammatory cytokine that plays multiple roles in the atherothrombotic process and that undergoes activation by the NLRP3 inflammasome, a process promoted by cholesterol crystals that in turn leads directly to increased production of IL-1 and IL-6.	Cholesterol	247-258	interleukin 1 beta	Homo sapiens	72-76
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	Flavonoids	21-30	interleukin 1 beta	Homo sapiens	120-128
23344020-6	2012	Oenothein B also markedly suppressed the production of inflammatory cytokines, such as IL-1beta and IL-6, in a dose-dependent manner.	oenothein B	0-11	interleukin 1 beta	Homo sapiens	87-95
23105097-0	2012	Interleukin 1beta regulation of FoxO1 protein content and localization: evidence for a novel ceramide-dependent mechanism.	Ceramides	93-101	interleukin 1 beta	Homo sapiens	0-17
23105097-8	2012	The IL-1beta effects on FoxO1 are counteracted, however, by the silencing or inhibition of neutral sphingomyelinase 2 (nSMase-2) using shRNAi, scyphostatin, or GW4869, as well as by the pharmacological inhibition of JNK and ERK.	scyphostatin	143-155	interleukin 1 beta	Homo sapiens	4-12
23105097-8	2012	The IL-1beta effects on FoxO1 are counteracted, however, by the silencing or inhibition of neutral sphingomyelinase 2 (nSMase-2) using shRNAi, scyphostatin, or GW4869, as well as by the pharmacological inhibition of JNK and ERK.	GW 4869	160-166	interleukin 1 beta	Homo sapiens	4-12
24175257-6	2012	Cyclosporine A (CsA) and tacrolimus (Tac) are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells, thereby inhibiting the transcription of the early activation genes of interleukin (IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-alpha, IL-1beta and IL-6.	Cyclosporine	0-14	interleukin 1 beta	Homo sapiens	295-303
23062767-12	2012	CONCLUSIONS: A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients.	Simvastatin	20-31	interleukin 1 beta	Homo sapiens	180-188
23062767-12	2012	CONCLUSIONS: A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients.	Simvastatin	70-81	interleukin 1 beta	Homo sapiens	180-188
23062767-12	2012	CONCLUSIONS: A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients.	Ezetimibe	87-96	interleukin 1 beta	Homo sapiens	180-188
23433161-5	2013	RESULTS: The activity of caspase-1 in 1 and 3 microg/ml CTP groups were (9.29 +- 0.30) and (8.67 +- 0.59) micromol/ml respectively which were both significantly increased compared to that (7.42 +- 0.59) micromol/ml in the control group (P &lt; 0.05) after 8 h exposure, but there was no significant difference in the activity of LDH and levels of IL-1beta in the cell culture media among the CTP and control groups.	Cytidine Triphosphate	56-59	interleukin 1 beta	Homo sapiens	347-355
23433161-7	2013	CONCLUSION: CTP treatment induced early increase in caspase-1 activity followed by the increase in LDH activity and IL-1 levels, indicative of pyroptosis in human bronchial epithelial cells.	Cytidine Triphosphate	12-15	interleukin 1 beta	Homo sapiens	116-120
23144495-0	2012	Cutting edge: FAS (CD95) mediates noncanonical IL-1beta and IL-18 maturation via caspase-8 in an RIP3-independent manner.	ammonium ferrous sulfate	14-17	interleukin 1 beta	Homo sapiens	47-55
23143333-10	2012	The binding affinity of cAMP for CAPS-associated mutant NLRP3 is substantially lower than for wild-type NLRP3, and the uncontrolled mature IL-1beta production from CAPS patients" peripheral blood mononuclear cells is attenuated by increasing cAMP.	Cyclic AMP	24-28	interleukin 1 beta	Homo sapiens	139-147
23143333-10	2012	The binding affinity of cAMP for CAPS-associated mutant NLRP3 is substantially lower than for wild-type NLRP3, and the uncontrolled mature IL-1beta production from CAPS patients" peripheral blood mononuclear cells is attenuated by increasing cAMP.	Cyclic AMP	242-246	interleukin 1 beta	Homo sapiens	139-147
22941914-10	2012	In muscle cells exposed to IFNgamma plus IL-1beta, IgG and/or prednisone down-regulated mRNA expression of IL-1beta 2.5-fold.	Prednisone	62-72	interleukin 1 beta	Homo sapiens	41-49
22941914-10	2012	In muscle cells exposed to IFNgamma plus IL-1beta, IgG and/or prednisone down-regulated mRNA expression of IL-1beta 2.5-fold.	Prednisone	62-72	interleukin 1 beta	Homo sapiens	107-115
22917079-7	2012	Pristane and other hydrocarbon oils induced IL-1beta secretion in THP-1 cells as well as in rat splenocytes.	pristane	0-8	interleukin 1 beta	Homo sapiens	44-52
22917079-7	2012	Pristane and other hydrocarbon oils induced IL-1beta secretion in THP-1 cells as well as in rat splenocytes.	Mineral Oil	19-35	interleukin 1 beta	Homo sapiens	44-52
24175257-6	2012	Cyclosporine A (CsA) and tacrolimus (Tac) are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells, thereby inhibiting the transcription of the early activation genes of interleukin (IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-alpha, IL-1beta and IL-6.	Cyclosporine	16-19	interleukin 1 beta	Homo sapiens	295-303
24175257-6	2012	Cyclosporine A (CsA) and tacrolimus (Tac) are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells, thereby inhibiting the transcription of the early activation genes of interleukin (IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-alpha, IL-1beta and IL-6.	Tacrolimus	25-35	interleukin 1 beta	Homo sapiens	295-303
24175257-6	2012	Cyclosporine A (CsA) and tacrolimus (Tac) are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells, thereby inhibiting the transcription of the early activation genes of interleukin (IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-alpha, IL-1beta and IL-6.	Tacrolimus	37-40	interleukin 1 beta	Homo sapiens	295-303
22885734-8	2012	The levels of these IL-1beta-induced chemokines in culture supernatant were decreased by a therapeutic concentration of tacrolimus.	Tacrolimus	120-130	interleukin 1 beta	Homo sapiens	20-28
22726220-9	2012	CONCLUSIONS: The trend towards improving ISR relative to glucose 0-0.5 h in patients treated with insulin supports the hypothesis that insulin secretion can be improved by blocking IL-1beta.	Glucose	57-64	interleukin 1 beta	Homo sapiens	181-189
23117931-7	2012	IL-1beta-caused an increase in COX-2 and VCAM-1 that was reduced by either DHT or 3beta-diol.	Dihydrotestosterone	75-78	interleukin 1 beta	Homo sapiens	0-8
23117931-7	2012	IL-1beta-caused an increase in COX-2 and VCAM-1 that was reduced by either DHT or 3beta-diol.	Androstane-3,17-diol	82-92	interleukin 1 beta	Homo sapiens	0-8
22831644-4	2012	In renal mesangial cells, AVX001 and AVX002 suppressed IL-1beta-induced PGE(2)  synthesis.	Prostaglandins E	72-75	interleukin 1 beta	Homo sapiens	55-63
23017228-2	2012	Direct treatment of THP-1 cells with Chry caused cell death, activation of caspase-1 and release of IL-1beta, while the addition of caspase-1 inhibitor, Z-YVAD-FMK, reduced IL-1beta, suggesting that Chry activated the caspase-1 mediated Nod-like receptor protein 3 (NLRP3) inflammasome; by comparison, LIB had less effects on all of these parameters.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	153-163	interleukin 1 beta	Homo sapiens	173-181
22105312-12	2012	DHA at low concentrations (1, 3, and 10 muM) did not afford protection, whereas at 30 muM, it caused deleterious effects, presumably by enhancing the production of NO, ROS, IL-1beta, and IL-6 and altering the intracellular calcium dynamics.	Docosahexaenoic Acids	0-3	interleukin 1 beta	Homo sapiens	173-181
22578178-10	2012	CCG also inhibited phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced interleukin-1beta production and mRNA expression by suppressing NF-kappaB activation and IkappaBalpha phosphorylation.	cationic colloidal gold	0-3	interleukin 1 beta	Homo sapiens	88-105
22578178-10	2012	CCG also inhibited phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced interleukin-1beta production and mRNA expression by suppressing NF-kappaB activation and IkappaBalpha phosphorylation.	Calcimycin	73-79	interleukin 1 beta	Homo sapiens	88-105
22885734-3	2012	MATERIALS AND METHODS: Tacrolimus and interleukin (IL)-1beta were added to cultured RSF.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	84-87	interleukin 1 beta	Homo sapiens	38-60
22885734-10	2012	Chemotaxis of polymorphonuclear cells in response to IL-1beta was also inhibited by tacrolimus.	Tacrolimus	84-94	interleukin 1 beta	Homo sapiens	53-61
22885734-11	2012	Nuclear translocation of p50 and p65 NF-kappaB in response to IL-1beta was decreased by tacrolimus.	Tacrolimus	88-98	interleukin 1 beta	Homo sapiens	62-70
22885734-12	2012	CONCLUSION: IL-1beta-induced chemokine expressions were down-regulated by tacrolimus, suggesting that tacrolimus exerts its anti-inflammatory effect partly through inhibiting chemokine production by RSF.	Tacrolimus	74-84	interleukin 1 beta	Homo sapiens	12-20
22885734-12	2012	CONCLUSION: IL-1beta-induced chemokine expressions were down-regulated by tacrolimus, suggesting that tacrolimus exerts its anti-inflammatory effect partly through inhibiting chemokine production by RSF.	Tacrolimus	102-112	interleukin 1 beta	Homo sapiens	12-20
23045481-9	2012	TcdA/TcdB exposure increased the expression of a number of inflammatory mediators associated with human CDI, including interleukin-6 (IL-6), gamma interferon (IFN-gamma), and IL-1beta.	tcda	0-4	interleukin 1 beta	Homo sapiens	175-183
22885734-12	2012	CONCLUSION: IL-1beta-induced chemokine expressions were down-regulated by tacrolimus, suggesting that tacrolimus exerts its anti-inflammatory effect partly through inhibiting chemokine production by RSF.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	199-202	interleukin 1 beta	Homo sapiens	12-20
23675280-2	2012	METHODS: Chondrocytes were cultured on alginate beads with IL-1beta or TGF-beta alone or both.	Alginates	39-47	interleukin 1 beta	Homo sapiens	59-67
22992945-0	2012	Sphingosine-1-phosphate inhibits interleukin-1beta-induced inflammation             in human articular chondrocytes.	sphingosine 1-phosphate	0-23	interleukin 1 beta	Homo sapiens	33-50
23045481-9	2012	TcdA/TcdB exposure increased the expression of a number of inflammatory mediators associated with human CDI, including interleukin-6 (IL-6), gamma interferon (IFN-gamma), and IL-1beta.	trimethylaminocarboxyldihydroboran	5-9	interleukin 1 beta	Homo sapiens	175-183
22992945-9	2012	S1P dose-dependently inhibited IL-1beta-induced NF-kappaB p65, cyclooxygenase (COX)-2, MMP-1, MMP-3, MMP-13 and MMP-14 mRNA expression in human chondrocytes and IL-1beta-induced PGE2 synthesis and GAG degradation in human cartilage explants.	Dinoprostone	178-182	interleukin 1 beta	Homo sapiens	31-39
22992945-9	2012	S1P dose-dependently inhibited IL-1beta-induced NF-kappaB p65, cyclooxygenase (COX)-2, MMP-1, MMP-3, MMP-13 and MMP-14 mRNA expression in human chondrocytes and IL-1beta-induced PGE2 synthesis and GAG degradation in human cartilage explants.	Glycosaminoglycans	197-200	interleukin 1 beta	Homo sapiens	31-39
22992945-10	2012	W146, a known S1P1 receptor antagonist, inhibited the active form of NF-kappaB p65 and COX-2 expression induced by IL-1beta.	W146	0-4	interleukin 1 beta	Homo sapiens	115-123
22922993-4	2012	Our results show that artemisinin significantly inhibited IL-1beta and TNF-alpha protein expression and the infiltration of macrophages.	artemisinin	22-33	interleukin 1 beta	Homo sapiens	58-66
22533969-12	2012	The iNOS inhibitor, 1400W, enhanced IL-1beta-induced AR expression; furthermore, the NO donor, NONOate, diminished the expression of the AR to a similar extent in gingival fibroblasts derived from both healthy patients and DIGO patients (p &lt; 0.05).	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	20-25	interleukin 1 beta	Homo sapiens	36-44
22533969-3	2012	2012 John Wiley &amp; Sons A/S Background and Objective:  In our previous study, we found that flutamide [an androgen receptor (AR) antagonist] inhibited the up-regulation of collagen induced by interleukin (IL)-1beta and/or nifedipine in gingival fibroblasts.	Flutamide	95-104	interleukin 1 beta	Homo sapiens	195-217
22658375-1	2012	Acute synovitis induced by deposition of calcium pyrophosphate (CPP) and monosodium urate crystals involves interleukin-1beta production and activation.	Calcium Pyrophosphate	41-62	interleukin 1 beta	Homo sapiens	108-125
22533969-4	2012	The present study attempted to verify the role of nitric oxide (NO) in the IL-1beta/nifedipine-AR pathway in gingival overgrowth.	Nitric Oxide	50-62	interleukin 1 beta	Homo sapiens	75-83
22533969-9	2012	IL-1beta strongly increased the expression of inducible nitric oxide synthase (iNOS) mRNA and the nitrite concentration in both healthy and DIGO cells (p &lt; 0.05).	Nitrites	98-105	interleukin 1 beta	Homo sapiens	0-8
22533969-10	2012	However, co-administration of IL-1beta and nifedipine largely abrogated the expression of iNOS mRNA and the nitrite concentration with the same treatment.	Nitrites	108-115	interleukin 1 beta	Homo sapiens	30-38
23188239-15	2012	The number of CD11b-positive cells as well as myeloperoxidase and IL-1 levels in the brains were significantly reduced by the VPA treatment.	Valproic Acid	126-129	interleukin 1 beta	Homo sapiens	66-70
22658375-1	2012	Acute synovitis induced by deposition of calcium pyrophosphate (CPP) and monosodium urate crystals involves interleukin-1beta production and activation.	Calcium Pyrophosphate	64-67	interleukin 1 beta	Homo sapiens	108-125
22658375-1	2012	Acute synovitis induced by deposition of calcium pyrophosphate (CPP) and monosodium urate crystals involves interleukin-1beta production and activation.	Uric Acid	73-89	interleukin 1 beta	Homo sapiens	108-125
23065818-3	2012	METHODS AND RESULTS: In the present report, decreases in the levels of inflammatory markers such as IL-6, MCP-1, and IL-1beta (mRNA and protein level) in human adipocytes and in 3T3-L1 adipocytes were observed after 1,25-dihydroxyvitamin D3 (1,25-(OH)(2) D(3) ) treatment.	Calcitriol	216-240	interleukin 1 beta	Homo sapiens	117-125
23046766-5	2012	The estimated 40% inhibitory concentration (IC(40)) of TEI-A00114 on interleukin (IL)-8 production induced by lipopolysaccharide and on IL-1beta in human whole blood cells in vitro were 9.8 x 10(-8) or 1.8 x 10(-9)M, respectively.	(2-hydroxy-2-methyl-cyclopentanone-5-ylidene)methyl-9,10-secopregna-5,7,10(19)-triene-1,3-diol	55-65	interleukin 1 beta	Homo sapiens	136-144
23150653-11	2012	Plaque suPAR levels correlated with plaque content of lipids and macrophages and with proinflammatory chemokines and cytokines monocyte chemoattractant protein 1, tumor necrosis factor alpha, interleukin 1beta, interleukin 6, platelet-derived growth factor AB/BB, monocyte inflammatory protein 1beta, regulated on activation normal T-cell expressed and secreted, and s-CD40L.	supar	7-12	interleukin 1 beta	Homo sapiens	192-209
22847064-5	2012	In this study, we observed that LOX-1 expression is induced upon toxic microglial activation, and discovered that LOX-1 is necessary in microglia for sensing soluble neuronal injury signal(s) in the conditioned medium to induce generation of pro-inflammatory mediators (IL-1beta, TNF-alpha, NO and ROS) that promote neurotoxicity.	ros	298-301	interleukin 1 beta	Homo sapiens	270-278
22672115-9	2012	CONCLUSIONS: IL-1 beta concentration seems to be increased in milk of mothers whose infants had BMJ.	(12R)-12-methyltetradecanoic acid	96-99	interleukin 1 beta	Homo sapiens	13-22
23285696-0	2012	The effect of phytic acid on the expression of NF-kappaB, IL-6 and IL-8 in IL-1beta-stimulated human colonic epithelial cells.	Phytic Acid	14-25	interleukin 1 beta	Homo sapiens	75-83
24278621-8	2012	The levels of IL-1 in the thymus and spleen; INF-gamma in serum; IL-2, IL-6, and IL-10 in the thymus; and IL-10 and IFN-gamma in the spleen decreased after ZEA administration.	Zearalenone	156-159	interleukin 1 beta	Homo sapiens	14-18
23327913-19	2012	The contents of IL-1beta in supernatants of normal fibroblasts and scar fibroblasts in groups of every concentration of oleic acid were significantly higher than those in corresponding BC and EC groups (with F values respectively 25.117, 9.137, P values all below 0.01).	Oleic Acid	120-130	interleukin 1 beta	Homo sapiens	16-24
23327913-19	2012	The contents of IL-1beta in supernatants of normal fibroblasts and scar fibroblasts in groups of every concentration of oleic acid were significantly higher than those in corresponding BC and EC groups (with F values respectively 25.117, 9.137, P values all below 0.01).	ec	192-194	interleukin 1 beta	Homo sapiens	16-24
22966128-11	2012	We recommend that future clinical trials of SaB stratify patients according to IL-10 and IL-1beta serum concentrations in order to better evaluate the impact of therapeutic interventions on patient outcome.	sab	44-47	interleukin 1 beta	Homo sapiens	89-97
22936809-0	2012	Resveratrol modulates interleukin-1beta-induced phosphatidylinositol 3-kinase and nuclear factor kappaB signaling pathways in human tenocytes.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	22-39
22936809-3	2012	An in vitro model of human tenocytes was used to examine the mechanism of resveratrol action on IL-1beta-mediated inflammatory signaling.	Resveratrol	74-85	interleukin 1 beta	Homo sapiens	96-104
22936809-4	2012	Resveratrol suppressed IL-1beta-induced activation of NF-kappaB and PI3K in a dose- and time-dependent manner.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	23-31
22936809-6	2012	IL-1beta-induced NF-kappaB and PI3K activation was inhibited by resveratrol or the inhibitors of PI3K (wortmannin), c-Src (PP1), and Akt (SH-5) through inhibition of IkappaB kinase, IkappaBalpha phosphorylation, and inhibition of nuclear translocation of NF-kappaB, suggesting that PI3K signaling pathway may be one of the signaling pathways inhibited by resveratrol to abrogate NF-kappaB activation.	Resveratrol	64-75	interleukin 1 beta	Homo sapiens	0-8
22936809-6	2012	IL-1beta-induced NF-kappaB and PI3K activation was inhibited by resveratrol or the inhibitors of PI3K (wortmannin), c-Src (PP1), and Akt (SH-5) through inhibition of IkappaB kinase, IkappaBalpha phosphorylation, and inhibition of nuclear translocation of NF-kappaB, suggesting that PI3K signaling pathway may be one of the signaling pathways inhibited by resveratrol to abrogate NF-kappaB activation.	Wortmannin	103-113	interleukin 1 beta	Homo sapiens	0-8
22936809-6	2012	IL-1beta-induced NF-kappaB and PI3K activation was inhibited by resveratrol or the inhibitors of PI3K (wortmannin), c-Src (PP1), and Akt (SH-5) through inhibition of IkappaB kinase, IkappaBalpha phosphorylation, and inhibition of nuclear translocation of NF-kappaB, suggesting that PI3K signaling pathway may be one of the signaling pathways inhibited by resveratrol to abrogate NF-kappaB activation.	Resveratrol	355-366	interleukin 1 beta	Homo sapiens	0-8
22936809-7	2012	Inhibition of PI3K by wortmannin attenuated IL-1beta-induced Akt and p65 acetylation, suggesting that p65 is a downstream component of PI3K/Akt in these responses.	Wortmannin	22-32	interleukin 1 beta	Homo sapiens	44-52
22936809-8	2012	The modulatory effects of resveratrol on IL-1beta-induced activation of NF-kappaB and PI3K were found to be mediated at least in part by the association between Sirt-1 and scleraxis and deacetylation of NF-kappaB and PI3K.	Resveratrol	26-37	interleukin 1 beta	Homo sapiens	41-49
23041168-11	2012	In conclusions, it is suggested that IL-1beta, IL-6, IL-8 and TNF-alpha were associated with TCE-induced hypersensitivity dermatitis.	Trichloroethylene	93-96	interleukin 1 beta	Homo sapiens	37-45
23164507-0	2012	Interleukin-1 beta-induced up-regulation of opioid receptors in the untreated and morphine-desensitized U87 MG human astrocytoma cells.	Morphine	82-90	interleukin 1 beta	Homo sapiens	0-18
23164507-3	2012	We hypothesized that IL-1beta up-regulates opioid receptors in human astrocytes in both untreated and morphine-desensitized states.	Morphine	102-110	interleukin 1 beta	Homo sapiens	21-29
23164507-10	2012	Treatment with IL-1beta also showed a significant up-regulation of the MOR in U87 MG cells desensitized with morphine.	Morphine	109-117	interleukin 1 beta	Homo sapiens	15-23
23164507-12	2012	CONCLUSION: Our results indicate that the pro-inflammatory cytokine, IL-1beta, affects opiate-dependent pathways by up-regulating the expression of the MOR in both untreated and morphine-desensitized U87 MG.	Morphine	178-186	interleukin 1 beta	Homo sapiens	69-77
23285690-6	2012	Furthermore, the role of signaling pathways involving p38 MAP kinase in IP6-induced down-regulation of IL-8 secretion by unstimulated and IL-1beta-stimulated cells in the presence of p38 MAP kinase activator (anisomycin) and inhibitor (SB 203580) was evaluated.	Phytic Acid	72-75	interleukin 1 beta	Homo sapiens	138-146
23285690-6	2012	Furthermore, the role of signaling pathways involving p38 MAP kinase in IP6-induced down-regulation of IL-8 secretion by unstimulated and IL-1beta-stimulated cells in the presence of p38 MAP kinase activator (anisomycin) and inhibitor (SB 203580) was evaluated.	Anisomycin	209-219	interleukin 1 beta	Homo sapiens	138-146
23285690-8	2012	Treatment of cells with IP6 for 3 h resulted in decreased p38 MAP kinase expression in both unstimulated and stimulated with IL-1beta cells.	Phytic Acid	24-27	interleukin 1 beta	Homo sapiens	125-133
22902523-7	2012	Prior morphine elevated IL-1beta mRNA at both sites, MHC-II and TLR4 in the trigeminal nucleus caudalis but not spinal cord, but not glial activation markers at either site.	Morphine	6-14	interleukin 1 beta	Homo sapiens	24-32
22962328-4	2012	METHODS AND RESULTS: We demonstrate that IL-1beta-conditioned medium from RAW 264.7 macrophages induces differentiation of human adipose tissue-derived mesenchymal stem cells to alpha-smooth muscle actin-positive SMCs, and the differentiated SMCs exhibited increased contractility in response to KCl and carbachol treatment.	Potassium Chloride	296-299	interleukin 1 beta	Homo sapiens	41-49
22962328-4	2012	METHODS AND RESULTS: We demonstrate that IL-1beta-conditioned medium from RAW 264.7 macrophages induces differentiation of human adipose tissue-derived mesenchymal stem cells to alpha-smooth muscle actin-positive SMCs, and the differentiated SMCs exhibited increased contractility in response to KCl and carbachol treatment.	Carbachol	304-313	interleukin 1 beta	Homo sapiens	41-49
22962328-9	2012	CONCLUSIONS: These results suggest that IL-1beta-activated macrophages promote differentiation of human adipose tissue-derived mesenchymal stem cells to SMCs through a prostaglandin F(2alpha)-mediated paracrine mechanism.	Prostaglandins F	168-183	interleukin 1 beta	Homo sapiens	40-48
22895087-7	2012	Both GG and LC705 induced interleukin-1beta production in macrophages that required caspase-1 activity.	lc705	12-17	interleukin 1 beta	Homo sapiens	26-43
22415590-0	2012	The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1beta-stimulated colon cancer cells.	Phytic Acid	14-36	interleukin 1 beta	Homo sapiens	117-125
22415590-5	2012	In the present study, the effect of IP6 on the expression of MMP and TIMP genes was evaluated in unstimulated and IL-1beta-stimulated colon cancer cell line Caco-2.	Phytic Acid	36-39	interleukin 1 beta	Homo sapiens	114-122
22415590-6	2012	MATERIALS AND METHODS: Real-time QRT-PCR was used to validate the transcription level of selected MMP and TIMP genes in Caco-2 cells after treatment with 1 ng/ml of IL-1beta, 2.5 mM of IP6, and both for 6, 12, and 24 h. RESULTS: Stimulation of cells with IL-1beta only resulted in an overexpression of MMP and their TIMP mRNAs.	Phytic Acid	185-188	interleukin 1 beta	Homo sapiens	165-173
22882764-7	2012	Thus, ATP-induced accumulation of the mature IL-1beta cytokine within extracellular compartments requires non-classical mechanisms of export from the cytosolic compartment.	Adenosine Triphosphate	6-9	interleukin 1 beta	Homo sapiens	45-53
22902304-0	2012	Genetic variants of TNFalpha, IL10, IL1beta, CTLA4 and TGFbeta1 modulate the indices of alcohol-induced liver injury in East Indian population.	Alcohols	88-95	interleukin 1 beta	Homo sapiens	36-43
22902304-11	2012	The risk genotype of IL1beta and TGFbeta1 also influences the total bilirubin, albumin and alanine aminotransferase levels among alcoholic "Bengalis".	Bilirubin	68-77	interleukin 1 beta	Homo sapiens	21-28
22802109-6	2012	RESULTS: Combined administration of ETN/MTX significantly inhibited the proliferation of T lymphocytes, decreased serum IL-6, TNF-alpha, IL-1beta, RANKL and macrophage supernatant IL-17, LT-alpha, increased serum IFN-gamma and macrophage supernatant IL-10.	Methotrexate	40-43	interleukin 1 beta	Homo sapiens	137-145
23248402-0	2012	Detection of interleukin -1beta from isolated human lymphocyte in response to lipopolysaccharide and lipoteichoic acid.	lipoteichoic acid	101-118	interleukin 1 beta	Homo sapiens	13-31
23248402-1	2012	AIM: To detect the interleukin -1beta levels from single and pooled isolated human lymphocytes in response to lipolysaccharide and lipoteichoic acid.	lipolysaccharide	110-126	interleukin 1 beta	Homo sapiens	19-37
23248402-1	2012	AIM: To detect the interleukin -1beta levels from single and pooled isolated human lymphocytes in response to lipolysaccharide and lipoteichoic acid.	lipoteichoic acid	131-148	interleukin 1 beta	Homo sapiens	19-37
22961265-6	2012	Inhibition of NO production (with l-NAME) resulted in upregulation of IRB-induced diaphragmatic IL-6, IL-10, IL-2, TNF-alpha, and IL-1beta levels by 50%, 53%, 60%, 47%, and 45%, respectively.	NG-Nitroarginine Methyl Ester	34-40	interleukin 1 beta	Homo sapiens	130-138
22930784-0	2012	Estradiol, tamoxifen, and flaxseed alter IL-1beta and IL-1Ra levels in normal human breast tissue in vivo.	Estradiol	0-9	interleukin 1 beta	Homo sapiens	41-49
22930784-0	2012	Estradiol, tamoxifen, and flaxseed alter IL-1beta and IL-1Ra levels in normal human breast tissue in vivo.	Tamoxifen	11-20	interleukin 1 beta	Homo sapiens	41-49
22930784-8	2012	RESULTS: We show a significant positive correlation between estradiol and in vivo levels of IL-1beta in breast tissue and abdominal sc fat, whereas IL-1Ra exhibited a significant negative correlation with estradiol in breast tissue.	Estradiol	60-69	interleukin 1 beta	Homo sapiens	92-100
22415590-8	2012	IP6 was also an efficient downregulator of MMP-1, MMP-9, and TIMP-2 genes transcription stimulated by IL-1beta in 6 h lasting culture.	Phytic Acid	0-3	interleukin 1 beta	Homo sapiens	102-110
22415590-9	2012	After 12 h, IL-1beta-induced MMP-2 mRNA expression was significantly reduced by IP6.	Phytic Acid	80-83	interleukin 1 beta	Homo sapiens	12-20
22415590-11	2012	IP6 (2.5 mM) influences constitutive expression of both MMP and TIMP genes and downregulates IL-1beta stimulated transcription of some of these genes.	Phytic Acid	0-3	interleukin 1 beta	Homo sapiens	93-101
22915814-5	2012	Poly(I C) pretreatment upregulated beta interferon (IFN-beta), IFN-gamma, IL-1beta, and tumor necrosis factor (TNF) gene expression in the lungs.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	74-82
22924711-1	2012	Acetate supplementation increases brain acetyl-CoA and histone acetylation and reduces lipopolysaccharide (LPS)-induced neuroglial activation and interleukin (IL)-1beta expression in vivo.	Acetates	0-7	interleukin 1 beta	Homo sapiens	146-168
22634346-3	2012	In the case of extracellular ATP, some of the immune responses are mediated through activation of the NLRP3 inflammasome and secretion of the cytokine, interleukin-1beta (IL-1beta), through a mechanism dependent on ligation of the P2X7 receptor.	Adenosine Triphosphate	29-32	interleukin 1 beta	Homo sapiens	152-169
22750393-0	2012	beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells.	beta Carotene	0-13	interleukin 1 beta	Homo sapiens	27-35
22634346-3	2012	In the case of extracellular ATP, some of the immune responses are mediated through activation of the NLRP3 inflammasome and secretion of the cytokine, interleukin-1beta (IL-1beta), through a mechanism dependent on ligation of the P2X7 receptor.	Adenosine Triphosphate	29-32	interleukin 1 beta	Homo sapiens	171-179
22750393-1	2012	Interleukin-1 beta (IL-1beta) induces endothelial dysfunction and reduces nitric oxide (NO) production.	Nitric Oxide	74-86	interleukin 1 beta	Homo sapiens	0-18
23026048-5	2012	Also, high glucose increased nuclear factor kappa B (NF-kappaB) p65 nuclear activity, tumor necrosis factor-alpha (TNF-alpha) and interleukin-lbeta (IL-1beta) levels.	Glucose	11-18	interleukin 1 beta	Homo sapiens	149-157
22750393-1	2012	Interleukin-1 beta (IL-1beta) induces endothelial dysfunction and reduces nitric oxide (NO) production.	Nitric Oxide	74-86	interleukin 1 beta	Homo sapiens	20-28
22750393-11	2012	Importantly, beta-carotene upregulated the IL-1beta-mediated decrease of CaMKKII, PZK1, LKB1, eNOS and PON-1.	beta Carotene	13-26	interleukin 1 beta	Homo sapiens	43-51
22750393-12	2012	beta-carotene inhibited IL-1beta-mediated cell adhesion of U937 to endothelial cells.	beta Carotene	0-13	interleukin 1 beta	Homo sapiens	24-32
22750393-15	2012	beta-carotene may contribute to the functional maintenance of vascular endothelial cells in a manner similar to HDL, protecting them against stimuli such as IL-1beta.	beta Carotene	0-13	interleukin 1 beta	Homo sapiens	157-165
23026048-8	2012	Collectively, these data suggest that high glucose stimulates TNF-alpha and IL-1beta secretion via inducing TLR2 through PKC-alpha and PKC-delta in human gingival fibroblasts.	Glucose	43-50	interleukin 1 beta	Homo sapiens	76-84
23290159-1	2012	OBJECTIVE: To explore the effects of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor gamma-stimulating activity, on the levels of Abeta1-42, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and cognition in elderly hypertensive patients with Alzheimer"s disease (AD).	Telmisartan	37-48	interleukin 1 beta	Homo sapiens	196-213
22972933-3	2012	This process occurred at the transcriptional level and was dependent on reactive oxygen species and IL-1R signaling; it was abrogated with an IL-1R antagonist or with IL-1-neutralizing Abs, whereas treatment with either rIL-1alpha or IL-1beta induced IL-23 secretion.	Reactive Oxygen Species	72-95	interleukin 1 beta	Homo sapiens	234-242
23083134-11	2012	Inhibition of ERK1/2 using U0126 or siRNA abolished EGF and/or IL-1beta-induced cell migration and invasion in a dose-dependent manner.	U 0126	27-32	interleukin 1 beta	Homo sapiens	63-71
22972933-4	2012	Dendritic cells treated with LPS and 3-methyladenine secreted enhanced levels of both IL-1beta and IL-23, and supernatants from these cells stimulated the innate secretion of IL-17, IFN-gamma, and IL-22 by gammadelta T cells.	3-methyladenine	37-52	interleukin 1 beta	Homo sapiens	86-94
22972931-4	2012	We found that 3-MA could enhance LPS-induced NF-kappaB activation and production of TNF-alpha, inducible NO synthase (iNOS), cyclooxygenase-2, IL-1beta, and IL-12.	3-methyladenine	14-18	interleukin 1 beta	Homo sapiens	143-151
22972931-8	2012	3-MA was found to enhance LPS-induced NF-kappaB activation, iNOS, and pro-IL-1beta expression, and these actions were reversed by either GSK3beta inhibitors or small interfering GSK3beta.	3-methyladenine	0-4	interleukin 1 beta	Homo sapiens	70-82
23059822-4	2012	Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels.	Uric Acid	19-28	interleukin 1 beta	Homo sapiens	153-170
23059822-4	2012	Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels.	Uric Acid	19-28	interleukin 1 beta	Homo sapiens	172-180
23059822-4	2012	Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels.	Silicon Dioxide	30-36	interleukin 1 beta	Homo sapiens	153-170
23059822-4	2012	Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels.	Silicon Dioxide	30-36	interleukin 1 beta	Homo sapiens	172-180
23059822-4	2012	Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels.	alum	41-45	interleukin 1 beta	Homo sapiens	153-170
23059822-4	2012	Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels.	alum	41-45	interleukin 1 beta	Homo sapiens	172-180
23059822-4	2012	Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels.	Adenosine Triphosphate	104-107	interleukin 1 beta	Homo sapiens	153-170
23059822-4	2012	Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1beta (IL-1beta) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels.	Adenosine Triphosphate	104-107	interleukin 1 beta	Homo sapiens	172-180
23059822-5	2012	Interestingly, not only ATP but also ADP and UTP are involved in IL-1beta production upon these Nlrp3 inflammasome activators through multiple purinergic receptor signaling.	Adenosine Triphosphate	24-27	interleukin 1 beta	Homo sapiens	65-73
23059822-5	2012	Interestingly, not only ATP but also ADP and UTP are involved in IL-1beta production upon these Nlrp3 inflammasome activators through multiple purinergic receptor signaling.	Adenosine Diphosphate	37-40	interleukin 1 beta	Homo sapiens	65-73
23059822-5	2012	Interestingly, not only ATP but also ADP and UTP are involved in IL-1beta production upon these Nlrp3 inflammasome activators through multiple purinergic receptor signaling.	Uridine Triphosphate	45-48	interleukin 1 beta	Homo sapiens	65-73
23034049-6	2012	RESULTS: Fluticasone and/or salmeterol at 1 and 100 nM inhibited CXCL10 release induced by IL-1beta and TNF-alpha, but not IFNgamma or all three cytokines (cytomix).	Fluticasone	9-20	interleukin 1 beta	Homo sapiens	91-99
23046548-8	2012	Unopsonized IE induced secretion of IL-6 (median= 622 pg/ml [IQR=1,250-240], n=9) but no IL-1beta or TNF, whereas PPS-opsonized IE induced secretion of IL-1beta (18.6 pg/mL [34.2-14.4]) and TNF (113 pg/ml [421-17.0]) and increased IL-6 secretion (2,195 pg/ml [4,658-1,095]).	pps	114-117	interleukin 1 beta	Homo sapiens	152-160
23034049-6	2012	RESULTS: Fluticasone and/or salmeterol at 1 and 100 nM inhibited CXCL10 release induced by IL-1beta and TNF-alpha, but not IFNgamma or all three cytokines (cytomix).	Salmeterol Xinafoate	28-38	interleukin 1 beta	Homo sapiens	91-99
22922340-7	2012	Treatment with lobolide (2.5-10 mumol/L) significantly suppressed LPS-induced production of TNFalpha and IL-1beta in both THP-1 cells and PBMCs.	lobolide	15-23	interleukin 1 beta	Homo sapiens	105-113
23031505-3	2012	An additional mechanism of injury related to asbestos exposure in MM development has been recently associated to inflammatory responses, principally driven by interleukin (IL)-1 beta (ss) activated within the inflammasome complex.NLRP3 inflammosome has been described as the intracellular sensor for asbestos able to induce inflammasome activation and IL-1ss secretion while NLRP1 is expressed in lung epithelial cells and alveolar macrophages and contributes to the immune response and to survival/apoptosis balance.	Asbestos	45-53	interleukin 1 beta	Homo sapiens	159-182
23031505-3	2012	An additional mechanism of injury related to asbestos exposure in MM development has been recently associated to inflammatory responses, principally driven by interleukin (IL)-1 beta (ss) activated within the inflammasome complex.NLRP3 inflammosome has been described as the intracellular sensor for asbestos able to induce inflammasome activation and IL-1ss secretion while NLRP1 is expressed in lung epithelial cells and alveolar macrophages and contributes to the immune response and to survival/apoptosis balance.	Asbestos	45-53	interleukin 1 beta	Homo sapiens	352-356
23031212-2	2012	The aim of this work is to find proteins whose secretion from cartilage cells under proinflammatory stimuli (IL-1beta) is regulated by CS, employing a novel quantitative proteomic approach.	Chondroitin Sulfates	135-137	interleukin 1 beta	Homo sapiens	109-117
23031212-9	2012	In normal chondrocytes stimulated with IL-1beta, CS reduces inflammation directly by decreasing the presence of several complement components (CFAB, C1S, CO3, and C1R) and also indirectly by increasing proteins such as TNFalpha-induced protein (TSG6).	Chondroitin Sulfates	49-51	interleukin 1 beta	Homo sapiens	39-47
22576756-8	2012	Up-regulation of SOCS-3 by IL-1 in G6 chondrocytes and its spontaneous expression in OA chondrocytes were reduced by mithramycin, a specific inhibitor of transcription factor Sp-1.	Plicamycin	117-128	interleukin 1 beta	Homo sapiens	27-31
22576756-9	2012	Overexpression of SOCS-3 in bovine chondrocytes reduced IL-1- and LPS-induced nitric oxide production and insulin-like growth factor 1-induced proteoglycan synthesis.	Nitric Oxide	78-90	interleukin 1 beta	Homo sapiens	56-60
22674197-6	2012	RESULTS: Among the various cytokines tested, interleukin-1beta (IL-1beta) induced differentiation of human MSCs into osteoblasts, which was confirmed by alkaline phosphatase activity, expression of RUNX2 mRNA, and strong alizarin red S staining.	Alizarin Red S	221-235	interleukin 1 beta	Homo sapiens	45-62
22840054-0	2012	Hyaluronan regulates PPARgamma and inflammatory responses in IL-1beta-stimulated human chondrosarcoma cells, a model for osteoarthritis.	Hyaluronic Acid	0-10	interleukin 1 beta	Homo sapiens	61-69
22674197-6	2012	RESULTS: Among the various cytokines tested, interleukin-1beta (IL-1beta) induced differentiation of human MSCs into osteoblasts, which was confirmed by alkaline phosphatase activity, expression of RUNX2 mRNA, and strong alizarin red S staining.	Alizarin Red S	221-235	interleukin 1 beta	Homo sapiens	64-72
22674197-8	2012	Silencing of either WNT5A or ROR2 by small interfering RNA with 2 different sequences reduced alkaline phosphatase activity, RUNX2 expression, and alizarin red S staining of human MSCs induced by IL-1beta.	Alizarin Red S	147-161	interleukin 1 beta	Homo sapiens	196-204
22770526-2	2012	After exposure to silver nanoparticles, production of IL-1beta, a critical cytokine involved in induction of innate immunity, significantly increased as particle size decreased.	Silver	18-24	interleukin 1 beta	Homo sapiens	54-62
22632542-5	2012	RESULTS: Colchicine significantly modulated monosodium urate-induced IL-1beta release, LPS-stimulated LDH release, and basal transcript levels of TNF-alpha and IL-6 in healthy controls and BD colchicine responders, but not in BD colchicine nonresponders.	Colchicine	9-19	interleukin 1 beta	Homo sapiens	69-77
22632542-5	2012	RESULTS: Colchicine significantly modulated monosodium urate-induced IL-1beta release, LPS-stimulated LDH release, and basal transcript levels of TNF-alpha and IL-6 in healthy controls and BD colchicine responders, but not in BD colchicine nonresponders.	Uric Acid	44-60	interleukin 1 beta	Homo sapiens	69-77
22632542-6	2012	Notably, colchicine showed contrasting effects on LPS-stimulated IL-1beta transcription, i.e. it increased in responders but decreased in nonresponders.	Colchicine	9-19	interleukin 1 beta	Homo sapiens	65-73
22632542-9	2012	Predicting responsiveness to colchicine in patients with BD may, therefore, be possible by examining alterations in IL-1beta transcript levels in LPS-stimulated PBMCs after colchicine treatment.	Colchicine	29-39	interleukin 1 beta	Homo sapiens	116-124
22632542-9	2012	Predicting responsiveness to colchicine in patients with BD may, therefore, be possible by examining alterations in IL-1beta transcript levels in LPS-stimulated PBMCs after colchicine treatment.	Colchicine	173-183	interleukin 1 beta	Homo sapiens	116-124
22888169-10	2012	MAIN FINDINGS: Using the human first trimester trophoblast cell line, HTR8, pravastatin significantly augmented, compared with no treatment, aPL-dependent secretion of interleukin (IL)-8 (P&lt; 0.05), IL-1beta (P&lt; 0.05) and soluble endoglin (P&lt; 0.01) but had no effect on aPL-induced up-regulation of vascular endothelial growth factor, placenta growth factor or growth-related oncogene alpha secretion.	Pravastatin	76-87	interleukin 1 beta	Homo sapiens	201-209
22769735-7	2012	RESULT(S): In IL-1beta-treated explants COX-2 mRNA and PGF(2alpha), concentrations were significantly down-regulated by CMA but not by DEX.	Prostaglandins F	55-58	interleukin 1 beta	Homo sapiens	14-22
22670565-0	2012	Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-kappaB-COX-2-IL-1beta pathway.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	131-139
22670565-0	2012	Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-kappaB-COX-2-IL-1beta pathway.	oridonin	22-30	interleukin 1 beta	Homo sapiens	131-139
22670565-7	2012	The pro-inflammatory cytokine interleukin-1beta (IL-1beta) has been reported to be involved in oridonin-induced efferocytosis in U937 cells and interact with NO to contribute to inflammatory responses.	oridonin	95-103	interleukin 1 beta	Homo sapiens	30-47
22670565-7	2012	The pro-inflammatory cytokine interleukin-1beta (IL-1beta) has been reported to be involved in oridonin-induced efferocytosis in U937 cells and interact with NO to contribute to inflammatory responses.	oridonin	95-103	interleukin 1 beta	Homo sapiens	49-57
22670565-8	2012	1400 W or L-NAME blocked the secretion of IL-1beta and the activation of NF-kappaB and COX-2.	NG-Nitroarginine Methyl Ester	10-16	interleukin 1 beta	Homo sapiens	42-50
22670565-10	2012	NO augmented the oridonin-induced efferocytosis by mediating autophagy and activating the NF-kappaB-COX-2-IL-1beta pathway.	oridonin	17-25	interleukin 1 beta	Homo sapiens	106-114
22813871-3	2012	The release, by LPS stimulated macrophages, of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) was also reduced by narirutin fraction in a dose-dependent manner.	narirutin	140-149	interleukin 1 beta	Homo sapiens	47-64
22813871-3	2012	The release, by LPS stimulated macrophages, of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) was also reduced by narirutin fraction in a dose-dependent manner.	narirutin	140-149	interleukin 1 beta	Homo sapiens	66-74
23170143-3	2012	Recent studies have shown that cerulein-activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species, which trigger the phosphorylation of the JAK1, STAT1, and STAT3 proteins and induce the production of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6, in pancreatic acinar cells.	Reactive Oxygen Species	110-133	interleukin 1 beta	Homo sapiens	298-320
21931968-9	2012	PGE0001 reduces IL-1beta-induced PGE(2) release in human HCA-7 colon and A549 lung cancer cell lines with EC(50) in the sub-micromolar range.	pge0001	0-7	interleukin 1 beta	Homo sapiens	16-24
22835428-2	2012	The purpose of the present study was to investigate the effect of paeoniflorin on the recombinant human interleukin-1beta (rhIL-1beta)-stimulated monocytes from the peripheral blood of healthy adults in vitro.	peoniflorin	66-78	interleukin 1 beta	Homo sapiens	104-121
21931968-9	2012	PGE0001 reduces IL-1beta-induced PGE(2) release in human HCA-7 colon and A549 lung cancer cell lines with EC(50) in the sub-micromolar range.	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	16-24
22526597-9	2012	Calcitriol attenuated the effect of TNF-alpha and IL-1beta to upregulate mRNA and protein expression of importin alpha3.	Calcitriol	0-10	interleukin 1 beta	Homo sapiens	50-58
22644784-8	2012	This is supported by the following data: (1) IL-1beta induces 473 serine phosphorylation of Akt; (2) IL-1beta-mediated Akt activation occurs in a PI-3K-dependent manner, and specific inhibition of PI-3K prevents Akt phosphorylation; and (3) inhibition of Akt prevents IL-1beta-mediated DEC1 and HIF-1alpha induction.	Serine	66-72	interleukin 1 beta	Homo sapiens	45-53
22441579-4	2012	The anti-inflammatory effects of atorvastatin were assessed by measuring the levels of IL-1beta, PGE(2) and MMP-3 by ELISA.	Atorvastatin	33-45	interleukin 1 beta	Homo sapiens	87-95
22441579-5	2012	Atorvastatin inhibited the increase in the production of IL-1beta, PGE(2) and MMP-3 in submandibular glands treated with anti-M(3) peptide IgG.	Atorvastatin	0-12	interleukin 1 beta	Homo sapiens	57-65
22644784-8	2012	This is supported by the following data: (1) IL-1beta induces 473 serine phosphorylation of Akt; (2) IL-1beta-mediated Akt activation occurs in a PI-3K-dependent manner, and specific inhibition of PI-3K prevents Akt phosphorylation; and (3) inhibition of Akt prevents IL-1beta-mediated DEC1 and HIF-1alpha induction.	Serine	66-72	interleukin 1 beta	Homo sapiens	101-109
22644784-8	2012	This is supported by the following data: (1) IL-1beta induces 473 serine phosphorylation of Akt; (2) IL-1beta-mediated Akt activation occurs in a PI-3K-dependent manner, and specific inhibition of PI-3K prevents Akt phosphorylation; and (3) inhibition of Akt prevents IL-1beta-mediated DEC1 and HIF-1alpha induction.	Serine	66-72	interleukin 1 beta	Homo sapiens	101-109
22441579-6	2012	A positive correlation between IL-1beta production with accumulation of PGE(2) and MMP-3 was observed.	Prostaglandins E	72-75	interleukin 1 beta	Homo sapiens	31-39
22922818-12	2012	Interestingly, we show that blocking other calcium pathways, including inositol triphosphate receptor, or NF-kappaB inhibits IgE-driven IL-1beta, another IL-1 family cytokine, but it has no influence on inducible IL-33 expression.	Calcium	43-50	interleukin 1 beta	Homo sapiens	136-144
22980179-7	2012	However, when comparing teeth that received the medication with those that did not, expression levels of IL-1beta, IFN-gamma, and IL-10 were statistically lower in those teeth that received calcium hydroxide.	Calcium Hydroxide	190-207	interleukin 1 beta	Homo sapiens	105-113
22955517-5	2012	Second, in IL-1beta-stimulated confluent and/or differentiated cells, lignan effects were tested on different soluble proinflammatory mediators quantified by enzyme immunoassays and on the NF-kappaB activation pathway by using cells transiently transfected.	Lignans	70-76	interleukin 1 beta	Homo sapiens	11-19
24250536-7	2012	Pantoprazole infusion have decreased the plasma IL-1beta concentrations (p = 0.041).	Pantoprazole	0-12	interleukin 1 beta	Homo sapiens	48-56
22507555-6	2012	SIRT1 inhibition by sirtinol or Sirt1 siRNA reversed the effects of melatonin on H(2) O(2) -mediated induction of pro-inflammatory cytokines (NO, PGE(2) , TNF-alpha, IL-1beta, and IL-8) and the expression of iNOS, COX-2, and cartilage destruction molecules.	Melatonin	68-77	interleukin 1 beta	Homo sapiens	166-174
22364664-10	2012	The level of IL-1beta in gingival crevicular fluid was positively correlated with TOS in both smokers and nonsmokers.	tos	82-85	interleukin 1 beta	Homo sapiens	13-21
22743177-9	2012	CONCLUSIONS: The preoperative and postoperative cytokine levels, in particular, interleukin-1beta, showed complex time-dependent relationships with triiodothyronine.	Triiodothyronine	148-164	interleukin 1 beta	Homo sapiens	80-97
22837207-7	2012	Compared to wild-type virus, NiVDeltaC induced increased expression of interleukin 1 beta (IL-1beta), IL-8, CXCL2, CXCL3, CXCL6, CCL20, and beta interferon.	nivdeltac	29-38	interleukin 1 beta	Homo sapiens	71-89
22837207-7	2012	Compared to wild-type virus, NiVDeltaC induced increased expression of interleukin 1 beta (IL-1beta), IL-8, CXCL2, CXCL3, CXCL6, CCL20, and beta interferon.	nivdeltac	29-38	interleukin 1 beta	Homo sapiens	91-99
22467534-5	2012	In the present study, we found that differential binding patterns of nuclear proteins to oligonucleotide probes containing the IL1B -31C allele compared to those with the T allele were due to specific binding of the transcription factor Yin Yang 1 (YY1).	Oligonucleotides	89-104	interleukin 1 beta	Homo sapiens	127-131
22483413-6	2012	The rate of eating was positively associated with IL-1beta independently of IL-6, body mass index, homeostasis model assessment for insulin resistance, alcohol intake, energy intake, smoking status, and physical activity.	Alcohols	152-159	interleukin 1 beta	Homo sapiens	50-58
22924492-6	2012	Hydrogen-bonding and electrostatic interactions of the silanol surfaces of fumed silica aggregates with the extracellular plasma membrane cause membrane perturbations sensed by the Nalp3 inflammasome, whose subsequent activation leads to secretion of the cytokine IL-1beta.	Hydrogen	0-8	interleukin 1 beta	Homo sapiens	264-272
22722257-5	2012	In patients with PDAC, circulating IL-6, TNF-alpha, IL-1beta, and IL-10 correlated with serum concentrations of vascular endothelial growth factor and basic fibroblast growth factor; circulating IL-6, IL-1beta, and TNF-alpha correlated with carbohydrate 19-9; and IL-8, IL-10, and TNF-alpha correlated with CEA levels.	pdac	17-21	interleukin 1 beta	Homo sapiens	52-60
22152988-3	2012	The objective of the present study was to investigate whether lycopene and beta-carotene in micelles (M), at concentrations that could be reached via the diet (10-25 mug/ml) could aid in the reduction of TNF-alpha plus IL-1beta-induced inflammation of Caco-2 human epithelial cells.	Lycopene	62-70	interleukin 1 beta	Homo sapiens	219-227
22152988-3	2012	The objective of the present study was to investigate whether lycopene and beta-carotene in micelles (M), at concentrations that could be reached via the diet (10-25 mug/ml) could aid in the reduction of TNF-alpha plus IL-1beta-induced inflammation of Caco-2 human epithelial cells.	beta Carotene	75-88	interleukin 1 beta	Homo sapiens	219-227
22322985-5	2012	The results showed that RIN markedly reduced the production of nitric oxide (NO), prostaglandins E(2) (PGE(2) ), monocyte chemoattractant protein (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in LPS-activated microglia.	rhyncophylline	24-27	interleukin 1 beta	Homo sapiens	199-216
22322985-5	2012	The results showed that RIN markedly reduced the production of nitric oxide (NO), prostaglandins E(2) (PGE(2) ), monocyte chemoattractant protein (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in LPS-activated microglia.	rhyncophylline	24-27	interleukin 1 beta	Homo sapiens	218-226
22750055-6	2012	Our study also shows that the association of astaxanthin with vitamin C greatly improved neutrophil phagocytic capacity, decreasing all reactive oxygen species measured, pro-inflammatory IL-1beta and TNF-alpha release, MPO activity and HClO production.	astaxanthine	45-56	interleukin 1 beta	Homo sapiens	187-195
22750055-6	2012	Our study also shows that the association of astaxanthin with vitamin C greatly improved neutrophil phagocytic capacity, decreasing all reactive oxygen species measured, pro-inflammatory IL-1beta and TNF-alpha release, MPO activity and HClO production.	Ascorbic Acid	62-71	interleukin 1 beta	Homo sapiens	187-195
22924492-6	2012	Hydrogen-bonding and electrostatic interactions of the silanol surfaces of fumed silica aggregates with the extracellular plasma membrane cause membrane perturbations sensed by the Nalp3 inflammasome, whose subsequent activation leads to secretion of the cytokine IL-1beta.	silanol	55-62	interleukin 1 beta	Homo sapiens	264-272
22924492-6	2012	Hydrogen-bonding and electrostatic interactions of the silanol surfaces of fumed silica aggregates with the extracellular plasma membrane cause membrane perturbations sensed by the Nalp3 inflammasome, whose subsequent activation leads to secretion of the cytokine IL-1beta.	Silicon Dioxide	81-87	interleukin 1 beta	Homo sapiens	264-272
23007908-3	2012	Low doses of IL-1beta (50 pg/mL) enhanced colony-forming units-fibroblastic (CFU-f) and -osteoblastic (CFU-o) number (up to 1.5-fold) and size (1.2-fold) in the absence of further supplements and glycosaminoglycan accumulation (1.4-fold) upon BM-MSC chondrogenic induction.	Glycosaminoglycans	196-213	interleukin 1 beta	Homo sapiens	13-21
22449852-4	2012	The CaSR activation by the calcimimatic cinacalcet (5muM) in adipose tissue and in vitro cultured LS14 adipose cells elicited an elevation in the expression of the proinflammatory cytokines IL6, IL1beta, TNFalpha, and the chemoattractant CCL2.	Cinacalcet	40-50	interleukin 1 beta	Homo sapiens	195-202
23006534-9	2012	RESULTS: Incubation with LPS, LTA or TCS significantly increased TNF-alpha, IL-1beta, IL-6, IL-8, IFN-gamma and IL-2 in comparison to incubation with RPMI alone.	lipoteichoic acid	30-33	interleukin 1 beta	Homo sapiens	76-84
23006534-9	2012	RESULTS: Incubation with LPS, LTA or TCS significantly increased TNF-alpha, IL-1beta, IL-6, IL-8, IFN-gamma and IL-2 in comparison to incubation with RPMI alone.	Technetium	37-40	interleukin 1 beta	Homo sapiens	76-84
23007908-4	2012	In osteogenically cultured BM-MSC, IL-1beta enhanced calcium deposition (62.2-fold) and BMP-2 mRNA expression by differential activation of NF-kappaB and ERK signalling.	Calcium	53-60	interleukin 1 beta	Homo sapiens	35-43
22884503-5	2012	The current study demonstrates that mitoxantrone inhibits lipopolysachharide (LPS) induction of NO, TNF-alpha, IL-1beta, and MCP-1 production by primary astrocytes.	Mitoxantrone	36-48	interleukin 1 beta	Homo sapiens	111-119
22652409-1	2012	P2X7, a damage-associated molecular pattern receptor and adenosine 5"-triphosphate (ATP)-gated cation channel, plays an important role in the activation of the NALP3 inflammasome and subsequent release of interleukin (IL)-1beta from human monocytes; however its role in monocytes from other species including the dog remains poorly defined.	Adenosine Triphosphate	57-82	interleukin 1 beta	Homo sapiens	205-227
22652409-1	2012	P2X7, a damage-associated molecular pattern receptor and adenosine 5"-triphosphate (ATP)-gated cation channel, plays an important role in the activation of the NALP3 inflammasome and subsequent release of interleukin (IL)-1beta from human monocytes; however its role in monocytes from other species including the dog remains poorly defined.	Adenosine Triphosphate	84-87	interleukin 1 beta	Homo sapiens	205-227
22884503-5	2012	The current study demonstrates that mitoxantrone inhibits lipopolysachharide (LPS) induction of NO, TNF-alpha, IL-1beta, and MCP-1 production by primary astrocytes.	lipopolysachharide	58-76	interleukin 1 beta	Homo sapiens	111-119
23103560-3	2012	RESULTS: Atorvastatin incubation resulted in significant decreases in the levels of TLR4 protein and mRNA, NF-kappaB expression, and levels of TNF-alpha, IL-6, and IL-1beta in LPS-induced THP-1 cells (P&lt;0.01).	Atorvastatin	9-21	interleukin 1 beta	Homo sapiens	164-172
22924724-8	2012	At 0 hours, IL-1beta expression was correlated with plasma fibrinogen concentration in healthy foals and with the neutrophil-to-lymphocyte ratio in foals with sepsis; IL-8 expression was correlated with monocyte count in foals with sepsis and with arterial pH, plasma fibrinogen concentration, and plasma lactate concentration in foals with peripartum asphyxia syndrome.	Lactic Acid	305-312	interleukin 1 beta	Homo sapiens	12-20
22587816-4	2012	However, overproduction of ROS, most frequently due to excessive stimulation of either reduced nicotinamide adenine dinucleotide phosphate (NADPH) by pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) or the mitochondrial electron transport chain and xanthine oxidase, results in oxidative stress.	Reactive Oxygen Species	27-30	interleukin 1 beta	Homo sapiens	230-247
22587816-4	2012	However, overproduction of ROS, most frequently due to excessive stimulation of either reduced nicotinamide adenine dinucleotide phosphate (NADPH) by pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) or the mitochondrial electron transport chain and xanthine oxidase, results in oxidative stress.	Reactive Oxygen Species	27-30	interleukin 1 beta	Homo sapiens	249-257
22587816-4	2012	However, overproduction of ROS, most frequently due to excessive stimulation of either reduced nicotinamide adenine dinucleotide phosphate (NADPH) by pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) or the mitochondrial electron transport chain and xanthine oxidase, results in oxidative stress.	NADP	95-138	interleukin 1 beta	Homo sapiens	230-247
22822059-0	2012	Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1beta-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets.	Dinoprostone	108-124	interleukin 1 beta	Homo sapiens	82-99
22822059-11	2012	IL-1beta inhibited glucose-stimulated insulin secretion equally in both WT and mPGES-1(-/-) islets, indicating that COX-2, not mPGES-1, mediates IL-1beta-induced PGE(2) production and subsequent inhibition of insulin secretion.	Glucose	19-26	interleukin 1 beta	Homo sapiens	0-8
23157890-9	2012	CONCLUSION: The abnormal production of IL-1beta, IFN-gamma, TNF-alpha, IL-8, MCP-1, MIP-1beta, IL-5 and IL-10 was related with the pathogenesis of hypersensitivity dermatitis induced by TCE.	Trichloroethylene	186-189	interleukin 1 beta	Homo sapiens	39-47
22888849-13	2012	In addition, IL-1beta, prepro-ET-1, TNF-alpha, and VEGF (vascular endothelial growth factor) mRNA expression levels were increased in the lungs of the DHMC group, and these increases were reduced toward normal levels in the Atorvastatin-treated group.	monocrotaline pyrrole	151-155	interleukin 1 beta	Homo sapiens	13-21
22832289-0	2012	Interleukin 1beta blockade improves signs and symptoms of chronic calcium pyrophosphate crystal arthritis resistant to treatment.	Calcium Pyrophosphate	66-87	interleukin 1 beta	Homo sapiens	0-17
22832289-3	2012	Interleukin 1beta (IL-1beta) plays a central role in the pathogenesis of inflammation induced by calcium pyrophosphate crystals, and IL-1beta blockade may be an effective treatment in patients with severe chronic calcium pyrophosphate crystal arthritis.	Calcium Pyrophosphate	97-118	interleukin 1 beta	Homo sapiens	0-17
22832289-3	2012	Interleukin 1beta (IL-1beta) plays a central role in the pathogenesis of inflammation induced by calcium pyrophosphate crystals, and IL-1beta blockade may be an effective treatment in patients with severe chronic calcium pyrophosphate crystal arthritis.	Calcium Pyrophosphate	97-118	interleukin 1 beta	Homo sapiens	19-27
22832289-3	2012	Interleukin 1beta (IL-1beta) plays a central role in the pathogenesis of inflammation induced by calcium pyrophosphate crystals, and IL-1beta blockade may be an effective treatment in patients with severe chronic calcium pyrophosphate crystal arthritis.	Calcium Pyrophosphate	213-234	interleukin 1 beta	Homo sapiens	0-17
22832289-3	2012	Interleukin 1beta (IL-1beta) plays a central role in the pathogenesis of inflammation induced by calcium pyrophosphate crystals, and IL-1beta blockade may be an effective treatment in patients with severe chronic calcium pyrophosphate crystal arthritis.	Calcium Pyrophosphate	213-234	interleukin 1 beta	Homo sapiens	19-27
22832289-3	2012	Interleukin 1beta (IL-1beta) plays a central role in the pathogenesis of inflammation induced by calcium pyrophosphate crystals, and IL-1beta blockade may be an effective treatment in patients with severe chronic calcium pyrophosphate crystal arthritis.	Calcium Pyrophosphate	213-234	interleukin 1 beta	Homo sapiens	133-141
22909148-9	2012	Administration of MgSO(4) to preeclamptic placentas resulted in an attenuation of the increased secretion of IL-1beta into the maternal circulation (P &lt; 0.001), and in a tendentious reduction in IL-1Ra.	mgso	18-22	interleukin 1 beta	Homo sapiens	109-117
22909148-12	2012	These findings suggest that the placenta may contribute to the elevation in serum IL-1beta and IL-1Ra in preeclampsia by increased secretion of these cytokines into the maternal circulation, and that MgSO(4) is able to attenuate this increased secretion of IL-1beta, and possibly IL-1Ra, in preeclampsia.	mgso	200-204	interleukin 1 beta	Homo sapiens	82-90
22909148-12	2012	These findings suggest that the placenta may contribute to the elevation in serum IL-1beta and IL-1Ra in preeclampsia by increased secretion of these cytokines into the maternal circulation, and that MgSO(4) is able to attenuate this increased secretion of IL-1beta, and possibly IL-1Ra, in preeclampsia.	mgso	200-204	interleukin 1 beta	Homo sapiens	257-265
22348531-3	2012	We found that treatment with melatonin significantly inhibited the production and expression of TNF-alpha and interleukin (IL)-1beta, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase, prostaglandin E(2) (PGE2), and nitric oxide (NO) in a dose-dependent manner.	Melatonin	29-38	interleukin 1 beta	Homo sapiens	110-132
22871551-9	2012	Silibinin was capable of reducing, at least in part, the levels of NF-kappaB and cytokines TNF-alpha and IL-1beta in preeclamptic women.	Silybin	0-9	interleukin 1 beta	Homo sapiens	105-113
22710193-7	2012	IL-1beta dose-dependently elevated migration of isolated first trimester EVT through fibronectin-coated transwells, which was inhibited in the presence of IL-1R antagonist (IL-1Ra), whereas proliferation of these cells was not affected.	EVT	73-76	interleukin 1 beta	Homo sapiens	0-8
22710193-10	2012	In conclusion, these data suggest that IL-1beta directly promotes trophoblast motility of first trimester EVT involving the uPA/PAI system.	EVT	106-109	interleukin 1 beta	Homo sapiens	39-47
22535545-3	2012	From previous studies using the parasagittal fluid-percussion brain injury model, we reported that the anti-inflammatory drug rolipram, a phosphodiesterase 4 inhibitor, reduced TNF-alpha and IL-1beta levels and improved histopathological outcome when administered 30 min prior to injury.	Rolipram	126-134	interleukin 1 beta	Homo sapiens	191-199
22684544-0	2012	Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by interleukin-1beta.	Pravastatin	0-11	interleukin 1 beta	Homo sapiens	118-135
22684544-2	2012	The aim of this study is to assess the ability of pravastatin to modify matrix metalloproteinase (MMP) messenger RNA (mRNA) expression and enzyme activity in a culture of normal human chondrocytes stimulated by interleukin-1beta.	Pravastatin	50-61	interleukin 1 beta	Homo sapiens	211-228
22796220-0	2012	Oxidized low-density lipoprotein induces secretion of interleukin-1beta by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation.	Reactive Oxygen Species	91-114	interleukin 1 beta	Homo sapiens	54-71
22684243-6	2012	Pre-exposure to H(2)O(2) significantly delayed the TNFalpha-induced expression of an NF-kappaB reporter gene and inflammatory proteins (intercellular adhesion molecule-1 and IL-1beta).	Hydrogen Peroxide	16-24	interleukin 1 beta	Homo sapiens	174-182
22698787-4	2012	BONCAT employed the incorporation of l-azidohomoalanine (AHA), an analog of methionine, into TNF-alpha or IL-1beta induced nascent proteins.	azidohomoalanine	37-55	interleukin 1 beta	Homo sapiens	106-114
22698787-4	2012	BONCAT employed the incorporation of l-azidohomoalanine (AHA), an analog of methionine, into TNF-alpha or IL-1beta induced nascent proteins.	Methionine	76-86	interleukin 1 beta	Homo sapiens	106-114
22842458-4	2012	OVN induced generalized increase in phosphorylated proteins, IL-1beta release and cell death in a time and dose dependent pattern.	Vanadates	0-3	interleukin 1 beta	Homo sapiens	61-69
22871832-8	2012	In primary cells, quercetin dose-dependently downregulated expression of TGF-beta-stimulated fibronectin and collagen Ialpha, and IL-1beta-enhanced MMP-2 and MMP-9.	Quercetin	18-27	interleukin 1 beta	Homo sapiens	130-138
22796220-4	2012	Here we show that the phagocytosis of ox-LDL can induce human macrophages to secrete IL-1beta by activating the NLRP3 inflammasome, and we further show that the activation of the NLRP3 inflammasome is dependent on the generation of reactive oxygen species and is related to the cathepsin B pathway.	Reactive Oxygen Species	232-255	interleukin 1 beta	Homo sapiens	85-93
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Dimethyl Sulfoxide	4-8	interleukin 1 beta	Homo sapiens	121-129
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Curcumin	27-35	interleukin 1 beta	Homo sapiens	121-129
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Dimethyl Sulfoxide	65-69	interleukin 1 beta	Homo sapiens	121-129
22863285-0	2012	IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1beta-mediated degradation of nucleus pulposus in vitro.	Polylactic Acid-Polyglycolic Acid Copolymer	22-51	interleukin 1 beta	Homo sapiens	76-84
22901528-11	2012	The selective A(2A)R antagonist, SCH58261 (50 nmol/l), prevented both the IL-1beta-induced phosphorylation of JNK and p38, as well as the IL-1beta-induced deregulation of calcium and the consequent enhanced neurotoxicity, whereas it had no effect on glutamate actions.	Glutamic Acid	250-259	interleukin 1 beta	Homo sapiens	138-146
22901528-12	2012	CONCLUSIONS: These results prompt the hypothesis that the neuroprotection afforded by A(2A)R blockade might result from this particular ability of A(2A)R to control IL-1beta-induced exacerbation of excitotoxic neuronal damage, through the control of MAPK activation and late calcium deregulation.	Calcium	275-282	interleukin 1 beta	Homo sapiens	165-173
22683572-12	2012	Most importantly, IL-1beta- and TNF-alpha-stimulated secretion was blocked by the CF transmembrane conductance regulator (CFTR) blocker, CFTRinh172 (100 mumol/l) but was not affected by the Ca(2+)-activated Cl(-) channel blocker, niflumic acid (1 mumol/l).	Niflumic Acid	230-243	interleukin 1 beta	Homo sapiens	18-26
22901528-5	2012	The effect of SCH58261 on the IL-1beta-induced phosphorylation of the mitogen-activated protein kinases (MAPKs) c-Jun N-terminal kinase (JNK) and p38 was evaluated by western blotting and immunocytochemistry.	5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine	14-22	interleukin 1 beta	Homo sapiens	30-38
22901528-9	2012	At 100 ng/ml, IL-1beta failed to affect neuronal viability but exacerbated the neurotoxicity induced by treatment with 100 mumol/l glutamate for 25 minutes (evaluated after 24 hours).	Glutamic Acid	131-140	interleukin 1 beta	Homo sapiens	14-22
22901528-10	2012	It is likely that this resulted from the ability of IL-1beta to enhance glutamate-induced calcium entry and late calcium deregulation, both of which were unaffected by IL-1beta alone.	Glutamic Acid	72-81	interleukin 1 beta	Homo sapiens	52-60
22901528-10	2012	It is likely that this resulted from the ability of IL-1beta to enhance glutamate-induced calcium entry and late calcium deregulation, both of which were unaffected by IL-1beta alone.	Calcium	90-97	interleukin 1 beta	Homo sapiens	52-60
22901528-10	2012	It is likely that this resulted from the ability of IL-1beta to enhance glutamate-induced calcium entry and late calcium deregulation, both of which were unaffected by IL-1beta alone.	Calcium	113-120	interleukin 1 beta	Homo sapiens	52-60
22901528-11	2012	The selective A(2A)R antagonist, SCH58261 (50 nmol/l), prevented both the IL-1beta-induced phosphorylation of JNK and p38, as well as the IL-1beta-induced deregulation of calcium and the consequent enhanced neurotoxicity, whereas it had no effect on glutamate actions.	5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine	33-41	interleukin 1 beta	Homo sapiens	74-82
22901528-11	2012	The selective A(2A)R antagonist, SCH58261 (50 nmol/l), prevented both the IL-1beta-induced phosphorylation of JNK and p38, as well as the IL-1beta-induced deregulation of calcium and the consequent enhanced neurotoxicity, whereas it had no effect on glutamate actions.	5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine	33-41	interleukin 1 beta	Homo sapiens	138-146
22901528-11	2012	The selective A(2A)R antagonist, SCH58261 (50 nmol/l), prevented both the IL-1beta-induced phosphorylation of JNK and p38, as well as the IL-1beta-induced deregulation of calcium and the consequent enhanced neurotoxicity, whereas it had no effect on glutamate actions.	Calcium	171-178	interleukin 1 beta	Homo sapiens	74-82
22901528-11	2012	The selective A(2A)R antagonist, SCH58261 (50 nmol/l), prevented both the IL-1beta-induced phosphorylation of JNK and p38, as well as the IL-1beta-induced deregulation of calcium and the consequent enhanced neurotoxicity, whereas it had no effect on glutamate actions.	Calcium	171-178	interleukin 1 beta	Homo sapiens	138-146
22901528-11	2012	The selective A(2A)R antagonist, SCH58261 (50 nmol/l), prevented both the IL-1beta-induced phosphorylation of JNK and p38, as well as the IL-1beta-induced deregulation of calcium and the consequent enhanced neurotoxicity, whereas it had no effect on glutamate actions.	Glutamic Acid	250-259	interleukin 1 beta	Homo sapiens	74-82
22659162-4	2012	In ECs treated with interleukin (IL)-1beta for 30 min, VE-cad Tyr phosphorylation, dissociation of the VE-cad/beta-catenin complex and transendothelial migration (TEM) of monocytes were increased.	Tyrosine	62-65	interleukin 1 beta	Homo sapiens	20-42
22659162-6	2012	Atorvastatin inhibited IL-1beta-induced Tyr phosphorylation of VE-cad by inhibiting RhoA and by dephosphorylating MLC.	Atorvastatin	0-12	interleukin 1 beta	Homo sapiens	23-31
22659162-6	2012	Atorvastatin inhibited IL-1beta-induced Tyr phosphorylation of VE-cad by inhibiting RhoA and by dephosphorylating MLC.	Tyrosine	40-43	interleukin 1 beta	Homo sapiens	23-31
22659162-9	2012	In addition, atorvastatin inhibited monocyte-induced VE-cad Tyr phosphorylation in ECs and attenuated IL-1beta-induced TEM of monocytes.	Atorvastatin	13-25	interleukin 1 beta	Homo sapiens	102-110
22863285-2	2012	The objective of this study was to investigate the therapeutic potential of poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with interleukin-1 receptor antagonist (IL-1ra) for sustained attenuation of interleukin-1 beta (IL-1beta) mediated degradative changes in the nucleus pulposus (NP), using an in vitro model.	Polylactic Acid-Polyglycolic Acid Copolymer	76-105	interleukin 1 beta	Homo sapiens	210-228
22863285-2	2012	The objective of this study was to investigate the therapeutic potential of poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with interleukin-1 receptor antagonist (IL-1ra) for sustained attenuation of interleukin-1 beta (IL-1beta) mediated degradative changes in the nucleus pulposus (NP), using an in vitro model.	Polylactic Acid-Polyglycolic Acid Copolymer	76-105	interleukin 1 beta	Homo sapiens	230-238
22867088-15	2012	In addition, pretreatment of HBEC with the antioxidant N-acetyl cysteine significantly inhibited DEP-induced ERK and Akt phosphorylation, and subsequent IL-8 and IL-1beta expression.	Acetylcysteine	55-72	interleukin 1 beta	Homo sapiens	162-170
22867088-15	2012	In addition, pretreatment of HBEC with the antioxidant N-acetyl cysteine significantly inhibited DEP-induced ERK and Akt phosphorylation, and subsequent IL-8 and IL-1beta expression.	dep	97-100	interleukin 1 beta	Homo sapiens	162-170
22295949-2	2012	METHODS: Lipopolysaccharide- and ATP-stimulated interleukin-1beta production was determined in the presence or absence of GSK1370319A in blood culture from 32 prospectively genotyped subjects.	Adenosine Triphosphate	33-36	interleukin 1 beta	Homo sapiens	48-65
22612225-4	2012	CYP2B protein degradation in response to IL-1 was attenuated by the selective LMP2 inhibitor UK-101, but not by the LMP7 inhibitor IPSI.	UK 101	93-99	interleukin 1 beta	Homo sapiens	41-45
22295949-2	2012	METHODS: Lipopolysaccharide- and ATP-stimulated interleukin-1beta production was determined in the presence or absence of GSK1370319A in blood culture from 32 prospectively genotyped subjects.	GSK 1370319A	122-133	interleukin 1 beta	Homo sapiens	48-65
22295949-3	2012	RESULTS: There was approximately 6.7-fold difference (P &lt; 0.0001) in IC50 for inhibition of ATP-stimulated interleukin-1beta release by GSK1370319A between individuals with the homozygous gain--(1068A) and loss-of-function (1513C) genotypes (expressing the 348T, 496E and 348A, 496A alleles, respectively).	Adenosine Triphosphate	95-98	interleukin 1 beta	Homo sapiens	110-127
22295949-3	2012	RESULTS: There was approximately 6.7-fold difference (P &lt; 0.0001) in IC50 for inhibition of ATP-stimulated interleukin-1beta release by GSK1370319A between individuals with the homozygous gain--(1068A) and loss-of-function (1513C) genotypes (expressing the 348T, 496E and 348A, 496A alleles, respectively).	GSK 1370319A	139-150	interleukin 1 beta	Homo sapiens	110-127
22542712-9	2012	In addition, CARD-024 partially stimulated members of the COX-2/IL-1beta inflammatory pathway.	1alpha-Hydroxyvitamin D5	13-21	interleukin 1 beta	Homo sapiens	64-72
22661653-9	2012	Quercetin had a significant suppression of tissue IL-6, IL-8, IL-1beta and TNFalpha mRNA expression in cultured orbital tissues from three GO samples relative to untreated control tissue (p&lt;0.05).	Quercetin	0-9	interleukin 1 beta	Homo sapiens	62-70
21789526-0	2012	Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1beta treated human intervertebral disc cells.	triptolide	0-10	interleukin 1 beta	Homo sapiens	133-141
22875918-6	2012	In addition, proinflammatory cytokines, TNFalpha and IL-1beta, were specifically increased in the SDH of pain-positive HIV patients.	sdh	98-101	interleukin 1 beta	Homo sapiens	53-61
22610149-11	2012	The proliferation of FLS and TNF-alpha, IL-1beta production from culture medium was significantly inhibited by rhEndostatin.	rhendostatin	111-123	interleukin 1 beta	Homo sapiens	40-48
22516051-3	2012	Interleukin1-beta, transforming growth factor-beta1, fibronectin and alphavbeta6 integrin have shown to be involved in the regulation of the MMP and TIMP gene expression in co-culture of CAFs and tumor cells.	cafs	187-191	interleukin 1 beta	Homo sapiens	0-17
22371121-9	2012	However, pretreatment with LY294002 significantly diminished IL-1beta-induced proliferation, migration, adhesion, and VEGF-A production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	interleukin 1 beta	Homo sapiens	61-69
22371121-12	2012	The phosphatidyl-inositol-3-kinase-Akt signaling pathway could be involved in the regulation of EPCs functions induced by IL-1beta.	Phosphatidylinositols	4-25	interleukin 1 beta	Homo sapiens	122-130
22592909-0	2012	Quercetin inhibits IL-1beta-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	19-27
22592909-0	2012	Quercetin inhibits IL-1beta-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast.	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	19-27
22592909-1	2012	This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs.	Quercetin	49-58	interleukin 1 beta	Homo sapiens	66-83
22592909-1	2012	This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs.	Quercetin	49-58	interleukin 1 beta	Homo sapiens	85-93
22610149-12	2012	CONCLUSION: Our data suggest that rhEndostatin inhibits adjuvant arthritis by down-regulating VEGF expression and suppression of TNF-alpha, IL-1beta production.	rhendostatin	34-46	interleukin 1 beta	Homo sapiens	140-148
22580886-2	2012	Interleukins (IL), such as IL-1beta, IL-6 and IL-10, have various functions in the regulation of the inflammatory response and in proliferative processes after inhalation of silica dust and can, therefore, influence the pathogenesis of asbestos-induced fibrosis and carcinogenesis.	Silicon Dioxide	174-180	interleukin 1 beta	Homo sapiens	27-35
22592909-1	2012	This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs.	Dinoprostone	238-254	interleukin 1 beta	Homo sapiens	66-83
22592909-1	2012	This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs.	Dinoprostone	238-254	interleukin 1 beta	Homo sapiens	85-93
22592909-1	2012	This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs.	Dinoprostone	256-260	interleukin 1 beta	Homo sapiens	66-83
22592909-1	2012	This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs.	Dinoprostone	256-260	interleukin 1 beta	Homo sapiens	85-93
22592909-4	2012	Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	36-44
22592909-4	2012	Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	176-184
22592909-4	2012	Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta.	Dinoprostone	147-151	interleukin 1 beta	Homo sapiens	36-44
22580886-2	2012	Interleukins (IL), such as IL-1beta, IL-6 and IL-10, have various functions in the regulation of the inflammatory response and in proliferative processes after inhalation of silica dust and can, therefore, influence the pathogenesis of asbestos-induced fibrosis and carcinogenesis.	Asbestos	236-244	interleukin 1 beta	Homo sapiens	27-35
22592909-4	2012	Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta.	Dinoprostone	147-151	interleukin 1 beta	Homo sapiens	176-184
22592909-5	2012	Quercetin also inhibits the phosphorylation of ERK-1/2, p38, JNK and activation of NF-kB by IL-1ed.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	92-96
22580716-9	2012	As compared with endotoxin-negative TAs, endotoxin-positive TAs demonstrated significantly greater tumor necrosis factor (TNF), interleukin (IL)-6, IL-10, and serpin peptidase inhibitor, clade E, member 1 (SERPINE1) mRNA, and IL-10, TNF, and IL-1beta protein.	tas	60-63	interleukin 1 beta	Homo sapiens	242-250
22817337-7	2012	In most cases, oat beta-glucan resulted in a dose-dependent increase in pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lung and peritoneal macrophages with and without exposure to HSV-1 infection.	beta-Glucans	19-30	interleukin 1 beta	Homo sapiens	100-108
22100755-0	2012	Double-walled carbon nanotubes trigger IL-1beta release in human monocytes through Nlrp3 inflammasome activation.	Carbon	14-20	interleukin 1 beta	Homo sapiens	39-47
22100755-5	2012	We show that DWCNTs-induced IL-1beta secretion is exclusively linked to caspase-1 and to Nlrp3 inflammasome activation in human monocytes.	dwcnts	13-19	interleukin 1 beta	Homo sapiens	28-36
22100755-7	2012	Moreover, inhibition of lysosomal acidification or cathepsin-B activation reduces DWCNT-induced IL-1beta secretion, suggesting that Nlrp3 inflammasome activation occurs via lysosomal destabilization.	dwcnt	82-87	interleukin 1 beta	Homo sapiens	96-104
22638761-0	2012	Fasitibant prevents the bradykinin and interleukin 1beta synergism on prostaglandin E2 release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes.	Dinoprostone	70-86	interleukin 1 beta	Homo sapiens	39-56
22638761-5	2012	IL-1beta increased PGE(2) release and COX-2 expression more than BK alone.	Prostaglandins E	19-22	interleukin 1 beta	Homo sapiens	0-8
22638761-6	2012	The combined treatment of cells with BK and IL-1beta induced an even increase of released PGE(2) and COX-2 gene and protein expression indicating a synergistic rather than an additive effect, not related to an increase of B(2) receptors density or its coupling.	Prostaglandins E	90-93	interleukin 1 beta	Homo sapiens	44-52
22638761-10	2012	BK can potentiate the COX-2 gene expression and consequent prostanoid production induced by IL-1beta.	Prostaglandins	59-69	interleukin 1 beta	Homo sapiens	92-100
22619232-0	2012	Melatonin inhibits IL1beta-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-kappaB activation.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	19-26
22619232-10	2012	Our results show that melatonin decreases the permeability of monolayer endothelial cell induced by IL1beta.	Melatonin	22-31	interleukin 1 beta	Homo sapiens	100-107
22619232-11	2012	At the same time, melatonin decreased the expression and activity of MMP9 by a NF-kappaB-dependent pathway in HUVECs induced by IL1beta.	Melatonin	18-27	interleukin 1 beta	Homo sapiens	128-135
22677362-3	2012	As in humans, cantharidin (12.5 mug/ear) generated macrophage-inflammatory protein (MIP)-2, monocyte chemoattractant protein (MCP)-1, keratinocyte-derived chemokine (KC), interleukin (IL)-6, IL-1beta, and myeloperoxidase (MPO) production, as well as neutrophil accumulation in mouse ear tissue.	Cantharidin	14-25	interleukin 1 beta	Homo sapiens	191-199
22704650-7	2012	Moreover, in human articular chondrocytes (HACs), some pathways of IL-1beta signal transduction were inhibited by sesamin: p38 and JNK.	sesamin	114-121	interleukin 1 beta	Homo sapiens	67-75
22768975-10	2012	RESULTS: EGCG significantly suppressed the LPS-induced expression of IL-1beta and TNF-alpha in hCMECs.	epigallocatechin gallate	9-13	interleukin 1 beta	Homo sapiens	69-77
22575517-4	2012	High-glucose medium increased the intracellular reactive oxygen species levels in HMC-1 and LAD2 cells after 2 days of incubation; in HMC-1 cells, the expression levels of tumor necrosis factor (TNF) alpha, interleukin (IL)-1beta, IL-6, and IL-13 were increased significantly.	high-glucose	0-12	interleukin 1 beta	Homo sapiens	207-229
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	interleukin 1 beta	Homo sapiens	232-240
22549135-4	2012	Adiponectin functioned synergistically with IL-1beta to activate IL-6, IL-8, and PGE2 expression in RA fibroblast-like synoviocytes; Levels of VEGF, MMP-1, and MMP-13 were not synergistically stimulated.	Dinoprostone	81-85	interleukin 1 beta	Homo sapiens	44-52
22689577-7	2012	In contrast, Sirt-1 activator resveratrol inhibited interleukin-1beta (IL-1beta)- and nicotinamide-induced NF-kappaB activation and p65 acetylation and suppressed the activation of IkappaB-alpha kinase.	Resveratrol	30-41	interleukin 1 beta	Homo sapiens	52-69
22689577-7	2012	In contrast, Sirt-1 activator resveratrol inhibited interleukin-1beta (IL-1beta)- and nicotinamide-induced NF-kappaB activation and p65 acetylation and suppressed the activation of IkappaB-alpha kinase.	Resveratrol	30-41	interleukin 1 beta	Homo sapiens	71-79
22689577-8	2012	Resveratrol also reversed the IL-1beta- or nicotinamide-induced up-regulation of various gene products that mediate inflammation (cyclooxygenase-2) and matrix degradation (matrix metalloproteinase-9) that are known to be regulated by NF-kappaB.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	30-38
21826646-3	2012	Low dose AMF-26 effectively inhibited the tumor necrosis factor-alpha (TNF-alpha)- or the interleukin-1beta (IL-1beta)-induced production of ICAM-1 in human umbilical vascular endothelial cells (HUVECs).	N-(pyridine-3-ylmethyl)-5-(7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-yl)-2-methylpenta-2,4-dienamide	9-15	interleukin 1 beta	Homo sapiens	90-107
21826646-3	2012	Low dose AMF-26 effectively inhibited the tumor necrosis factor-alpha (TNF-alpha)- or the interleukin-1beta (IL-1beta)-induced production of ICAM-1 in human umbilical vascular endothelial cells (HUVECs).	N-(pyridine-3-ylmethyl)-5-(7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-yl)-2-methylpenta-2,4-dienamide	9-15	interleukin 1 beta	Homo sapiens	109-117
22517618-0	2012	Prostaglandin E2 represses interleukin 1 beta-induced inflammatory mediator output from pregnant human myometrial cells through the EP2 and EP4 receptors.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	27-45
22517618-5	2012	Using selective EP receptor agonists and a selective EP(4) antagonist, we show that PGE(2) mediates the repression of IL-1beta-induced release of CXCL8, CCL2, and CSF2 via activation of the EP(2) and EP(4) receptors.	Prostaglandins E	84-87	interleukin 1 beta	Homo sapiens	118-126
22762240-0	2012	Enhanced interleukin-1beta production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals.	Uric Acid	127-132	interleukin 1 beta	Homo sapiens	9-26
23034253-9	2012	The inhibitory effect of LD-1227 on the IL-1beta-induced expression of these genes was mediated at least in part via suppression of NF-kB p65.	ld-1227	25-32	interleukin 1 beta	Homo sapiens	40-48
22731727-5	2012	CBA revealed a Th1 cytokine profile featuring increased IFN-gamma, TNF-alpha, and IL-1beta levels.	cba	0-3	interleukin 1 beta	Homo sapiens	82-90
22561121-1	2012	Previously, the authors reported that zaprinast, an inhibitor of cGMP-selective phosphodiesterases, induced the secretions of TNF-alpha and IL-1beta by microglia and enhanced the induction of iNOS by lipopolysaccharide (LPS).	zaprinast	38-47	interleukin 1 beta	Homo sapiens	140-148
22561121-3	2012	Zaprinast was found to activate ERK1/2, p38 MAPK, JNK, NFkappaB, and PI3K/Akt, and subsequently, induce the mRNA expressions of IL-1alpha, IL-1beta, TNF-alpha, CCL2, CCL4, CXCL1, CXCL2, and CD14.	zaprinast	0-9	interleukin 1 beta	Homo sapiens	139-147
22521247-11	2012	Newborn MoDCs displayed impaired LPS/ATP-induced caspase-1-mediated IL-1beta production but robust 3M-002-induced caspase-1-mediated inflammasome activation independent of exogenous ATP.	Adenosine Triphosphate	37-40	interleukin 1 beta	Homo sapiens	68-76
22831977-0	2012	Increased expression of interleukin-1beta in triglyceride-induced macrophage cell death is mediated by p38 MAP kinase.	Triglycerides	45-57	interleukin 1 beta	Homo sapiens	24-41
22831977-3	2012	TG treatment induced a dramatic decrease in interleukin-1beta (IL-1beta) mRNA expression in a dose- and time-dependent manner.	Triglycerides	0-2	interleukin 1 beta	Homo sapiens	44-61
22831977-3	2012	TG treatment induced a dramatic decrease in interleukin-1beta (IL-1beta) mRNA expression in a dose- and time-dependent manner.	Triglycerides	0-2	interleukin 1 beta	Homo sapiens	63-71
22831977-5	2012	To identify signaling pathways involved in TG-induced downregulation of IL-1beta, we added p38 MAPK, protein kinase C (PKC) or c-Raf1 specific inhibitors.	Triglycerides	43-45	interleukin 1 beta	Homo sapiens	72-80
22831977-6	2012	We found that inhibition of p38 MAPK alleviated the TG-induced downregulation of IL-1beta, whereas inhibition of PKC and c-Raf1 had no effect.	Triglycerides	52-54	interleukin 1 beta	Homo sapiens	81-89
22831977-8	2012	Our results suggest that downregulation of IL-1beta expression by TG-treated macrophages may play a role during atherogenesis.	Triglycerides	66-68	interleukin 1 beta	Homo sapiens	43-51
23058021-5	2012	Silica stimulation showed a significant increase of IL-1alpha and IL-1beta in cultured medium, and an increased gene expression of CTGF in cultured fibroblasts at 1 hour, as well as an up-regulation of the COL1A2 gene at 24-hour time point.	Silicon Dioxide	0-6	interleukin 1 beta	Homo sapiens	66-74
22966535-7	2012	The expression level of inflammation-related proteins such as IL-1 beta were increased in imidazolidinyl urea-treated cells.	imidazolidinyl urea	90-109	interleukin 1 beta	Homo sapiens	62-71
22573548-9	2012	Interestingly, it also abolished IL-1beta-evoked reactive oxygen species (ROS) generation and p47 NADPH oxidase activation.	Reactive Oxygen Species	49-72	interleukin 1 beta	Homo sapiens	33-41
22573548-9	2012	Interestingly, it also abolished IL-1beta-evoked reactive oxygen species (ROS) generation and p47 NADPH oxidase activation.	Reactive Oxygen Species	74-77	interleukin 1 beta	Homo sapiens	33-41
22547677-6	2012	Consistent with this, LPS stimulation-induced ADP-ribosylation at the nucleosome-occupied promoters of il-1beta, mip-2, and csf2 facilitates NF-kappaB recruitment and the transcription of these genes in macrophages.	Adenosine Diphosphate	46-49	interleukin 1 beta	Homo sapiens	103-111
21468727-6	2012	Production of IL-6, IL-8, vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE(2)) in response to IL-1beta was significantly increased in cells at passage 7 compared with passage 3.	Dinoprostone	73-89	interleukin 1 beta	Homo sapiens	114-122
22512945-4	2012	COS induced up-regulation of a total of 11 genes including CCL20 and IL8 and concurrent down-regulation of 10 genes including pro-inflammatory mediators CCL15, CCL25 and IL1B.	oligochitosan	0-3	interleukin 1 beta	Homo sapiens	170-174
22607938-11	2012	Interleukin (IL)-1beta in tears was 36% of baseline (P=0.053) in the tofacitinib 0.005% QD group and 95% of baseline (P &gt; 0.20) in the vehicle group.	tofacitinib	69-80	interleukin 1 beta	Homo sapiens	0-22
21468727-0	2012	Increased expression of IL-1 receptors in response to IL-1beta may produce more IL-6, IL-8, VEGF, and PGE2 in senescent synovial cells induced in vitro than in presenescent cells.	Dinoprostone	102-106	interleukin 1 beta	Homo sapiens	24-28
21468727-6	2012	Production of IL-6, IL-8, vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE(2)) in response to IL-1beta was significantly increased in cells at passage 7 compared with passage 3.	Prostaglandins E	91-94	interleukin 1 beta	Homo sapiens	114-122
21468727-0	2012	Increased expression of IL-1 receptors in response to IL-1beta may produce more IL-6, IL-8, VEGF, and PGE2 in senescent synovial cells induced in vitro than in presenescent cells.	Dinoprostone	102-106	interleukin 1 beta	Homo sapiens	54-62
22508517-5	2012	Human fibroblasts exposed to very-long-chain fatty acids exhibited increased mRNA expression of IL-1alpha and IL-1beta cytokines.	-chain fatty acids	38-56	interleukin 1 beta	Homo sapiens	110-118
22784287-7	2012	Volume priming in CPB for CABG patients using HA or HES preparation had less tendency for intense inflammatory response with lower levels of TNF-alpha, IL-1 beta , IL-6 and higher levels of IL-10 compared to patients treated with RS.	Hydroxyethyl Starch Derivatives	52-55	interleukin 1 beta	Homo sapiens	152-161
22429778-11	2012	Ocular irradiation from a Ru-106 plaque promoted an increase in the levels of IL-6, IL-8 and IL-1beta, modulation of which could be useful in managing radiation-related side effects.	Ruthenium-106	26-32	interleukin 1 beta	Homo sapiens	93-101
22294637-12	2012	Modulation of miR-199a* expression also caused significant inhibition of IL-1beta-induced upregulation of mPGES1 and prostaglandin E(2) production in OA chondrocytes.	Dinoprostone	117-135	interleukin 1 beta	Homo sapiens	73-81
22521737-5	2012	In contrast, genistein, an estrogen receptor ligand, postpones the activation of MAPKs induced by IL-1beta.	Genistein	13-22	interleukin 1 beta	Homo sapiens	98-106
22542504-5	2012	Using primary human brain vascular smooth muscle cells (HBVSMC), we tested whether DHT"s effect on IL-1beta induced COX-2 expression was mediated via AR or ERbeta.	Dihydrotestosterone	83-86	interleukin 1 beta	Homo sapiens	99-107
22542504-8	2012	When applied to HBVSMC, DHT (10nM; 18 h) attenuated IL-1beta-induced increases in COX-2 protein expression.	Dihydrotestosterone	24-27	interleukin 1 beta	Homo sapiens	52-60
22572643-9	2012	The ability of alpha-tocopherol to affect IL-1beta production was influenced by the IL10 -592 and -1082 polymorphisms (P = 0.025 and P = 0.016, respectively).	alpha-Tocopherol	15-31	interleukin 1 beta	Homo sapiens	42-50
22768773-0	2012	[Influence of carbon monoxide on the expression of adhesion molecules stimulated with tumor necrosis factor-alpha and interleukin-1beta on human gingival fibroblasts].	Carbon Monoxide	14-29	interleukin 1 beta	Homo sapiens	118-135
22595111-8	2012	The IL-1beta-induced sVCAM-1 production was not inhibited but rather enhanced by aspirin, a cyclooxygenase (COX) inhibitor.	Aspirin	81-88	interleukin 1 beta	Homo sapiens	4-12
22481026-7	2012	Pretreatment with either CFTR(inh172) or GlyH101 inhibitors decreased the basal cell content of both prostaglandins, and so did acute stimulation with IL-1beta, but the latter was dramatically reversed in CFTR(inh172)-treated cells.	N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide	41-48	interleukin 1 beta	Homo sapiens	151-159
22283836-12	2012	The addition of interleukin-1beta, an important cytokine during the cutaneous wound healing process, enabled the upregulation of hBD2 expression of both normal- and high-glucose cultivated keratinocytes, but the absolute levels of hBD2 were still significantly lower in the high-glucose-treated group.	Glucose	170-177	interleukin 1 beta	Homo sapiens	16-33
22283836-12	2012	The addition of interleukin-1beta, an important cytokine during the cutaneous wound healing process, enabled the upregulation of hBD2 expression of both normal- and high-glucose cultivated keratinocytes, but the absolute levels of hBD2 were still significantly lower in the high-glucose-treated group.	Glucose	279-286	interleukin 1 beta	Homo sapiens	16-33
22595111-10	2012	U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene), a mitogen-activated protein kinase kinase (MEK) inhibitor, attenuated IL-1beta-induced sVCAM-1 production.	U 0126	0-5	interleukin 1 beta	Homo sapiens	139-147
22595111-10	2012	U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene), a mitogen-activated protein kinase kinase (MEK) inhibitor, attenuated IL-1beta-induced sVCAM-1 production.	U 0126	7-66	interleukin 1 beta	Homo sapiens	139-147
22332123-9	2012	RESULTS: SFN inhibited the production of PGE2 and NO induced by IL-1beta and TNF-alpha.	Dinoprostone	41-45	interleukin 1 beta	Homo sapiens	64-72
22434859-2	2012	Compound IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) was found to be a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages.	11H-indeno(1,2-b)quinoxalin-11-one oxime	15-55	interleukin 1 beta	Homo sapiens	161-169
22337228-5	2012	Fatty acids stimulate IL1beta expression and may promote inflammation, causing hyperglycemia and insulin resistance.	Fatty Acids	0-11	interleukin 1 beta	Homo sapiens	22-29
22661925-0	2012	Inflammasome-IL-1beta Signaling Mediates Ethanol Inhibition of Hippocampal Neurogenesis.	Ethanol	41-48	interleukin 1 beta	Homo sapiens	13-21
22661925-5	2012	Here, we demonstrated a key role of proinflammatory cytokine IL-1beta signaling in mediating ethanol inhibition of neurogenesis.	Ethanol	93-100	interleukin 1 beta	Homo sapiens	61-69
22661925-6	2012	Ethanol inhibition of neurogenesis was reversed by neutralizing antibody to IL-1beta or blockade of the IL-1beta receptor with antagonist IL-1RIa.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	76-84
22661925-6	2012	Ethanol inhibition of neurogenesis was reversed by neutralizing antibody to IL-1beta or blockade of the IL-1beta receptor with antagonist IL-1RIa.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	104-112
22661925-7	2012	Ethanol-impaired neurogenesis is associated with strong induction of IL-1beta and inflammasome proteins NALP1 and NALP3 in both neurons and astrocytes.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	69-77
22661925-8	2012	Blockade of IL-1beta synthesis with inflammasome inhibitors Parthenolide and Bay11708 significantly reversed ethanol inhibited neurogenesis.	parthenolide	60-72	interleukin 1 beta	Homo sapiens	12-20
22661925-8	2012	Blockade of IL-1beta synthesis with inflammasome inhibitors Parthenolide and Bay11708 significantly reversed ethanol inhibited neurogenesis.	bay11708	77-85	interleukin 1 beta	Homo sapiens	12-20
22661925-8	2012	Blockade of IL-1beta synthesis with inflammasome inhibitors Parthenolide and Bay11708 significantly reversed ethanol inhibited neurogenesis.	Ethanol	109-116	interleukin 1 beta	Homo sapiens	12-20
22661925-10	2012	Together, these novel findings demonstrate that targeting inflammasome-IL-1beta signaling can normalize ethanol-impaired hippocampal neurogenesis, which may have therapeutic implications for treatment of cognitive impairment associated with hippocampal dysfunction in alcoholics.	Ethanol	104-111	interleukin 1 beta	Homo sapiens	71-79
22654757-5	2012	We have recently reported that AKR1B1 was expressed and modulated in association with PGF2alpha production in response to IL-1beta in the human endometrium.	Dinoprost	86-95	interleukin 1 beta	Homo sapiens	122-130
22654757-7	2012	Using human endometrial cells, prostate, and vascular smooth muscle cells, cardiomyocytes and endothelial cells we demonstrate that IL-1beta is able to up regulate COX-2 and AKR1B1 proteins as well as PGF2alpha production under normal glucose concentrations.	Dinoprost	201-210	interleukin 1 beta	Homo sapiens	132-140
22654757-7	2012	Using human endometrial cells, prostate, and vascular smooth muscle cells, cardiomyocytes and endothelial cells we demonstrate that IL-1beta is able to up regulate COX-2 and AKR1B1 proteins as well as PGF2alpha production under normal glucose concentrations.	Glucose	235-242	interleukin 1 beta	Homo sapiens	132-140
22403784-5	2012	The IL-1beta-induced decrease in TER was prevented by small hairpin RNA silencing of PKC-theta or by treatment with the isoform-selective PKC inhibitor Go6976 but not by PKC inhibitors that are selective for all PKC isoforms other than PKC-theta.	Go 6976	152-158	interleukin 1 beta	Homo sapiens	4-12
22616846-6	2012	Prostaglandins derived from the cyclooxygenase (COX) pathway were determined by liquid-chromatography mass spectrometry in supernatants from interleukin (IL) 1beta-activated fibroblast-like synoviocytes (FLS) treated with methotrexate.	Prostaglandins	0-14	interleukin 1 beta	Homo sapiens	141-163
22608202-0	2012	Serum amyloid A triggers the mosodium urate -mediated mature interleukin-1beta production from human synovial fibroblasts.	mosodium urate	29-43	interleukin 1 beta	Homo sapiens	61-78
22608202-1	2012	BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive.	Uric Acid	12-28	interleukin 1 beta	Homo sapiens	89-106
22608202-1	2012	BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive.	Uric Acid	12-28	interleukin 1 beta	Homo sapiens	108-116
22608202-1	2012	BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive.	Uric Acid	30-33	interleukin 1 beta	Homo sapiens	89-106
22608202-1	2012	BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive.	Uric Acid	30-33	interleukin 1 beta	Homo sapiens	108-116
22978105-8	2012	The contents of IL-1beta and NO were also lower in the BZD nutritive medium group with statistical difference when compared with those of the other two groups (P &lt; 0.05).	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	55-58	interleukin 1 beta	Homo sapiens	16-24
22403784-6	2012	Decreased TER coincided with increased phosphorylation of regulatory myosin light chain and with increased proapoptotic signaling indicated by decreased uptake of mitotracker red in response to IL-1beta treatment.	red dye CMXRos	163-178	interleukin 1 beta	Homo sapiens	194-202
22366483-8	2012	GEM-PU-PL12% most efficiently inhibited the proliferation of cholangiocarcinoma cells and most highly induced pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-12) and p38 MAPKs in the cells.	gem-pu-pl12	0-11	interleukin 1 beta	Homo sapiens	149-157
22119045-0	2012	Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1beta or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	100-108
22574737-10	2012	RESULTS: Compared with placebo, butyrate therapy led to the early reduction of macrophages, pus cells, IL-8 and IL-1beta in the stool and improvement in rectal histopathology.	Butyrates	32-40	interleukin 1 beta	Homo sapiens	112-120
22059850-6	2012	RESULTS: Short-chain fatty acids, at 20 mM, induced interleukin (IL)-8, IL-6, and IL-1beta release, while lower levels (0.02-2 mM) did not induce cytokine secretion.	Fatty Acids, Volatile	9-32	interleukin 1 beta	Homo sapiens	82-90
21344174-8	2012	Theanine also repressed phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced TNF-alpha, IL-1beta, IL-6, and IL-8 secretion by suppressing NF-kappaB activation.	theanine	0-8	interleukin 1 beta	Homo sapiens	104-112
21344174-8	2012	Theanine also repressed phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced TNF-alpha, IL-1beta, IL-6, and IL-8 secretion by suppressing NF-kappaB activation.	Calcimycin	78-84	interleukin 1 beta	Homo sapiens	104-112
22119045-8	2012	Nicotine increased the secretion of IL-8 from HGECs that were cultured in the presence of IL-1beta or P. gingivalis LPS and also induced the phosphorylation of extracellular signal-regulated kinase (ERK) in epi 4.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	90-98
22808498-8	2012	Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid.	Cobalt	42-48	interleukin 1 beta	Homo sapiens	144-152
22480848-4	2012	They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Homo sapiens	82-90
22480848-4	2012	They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Homo sapiens	185-193
22808498-8	2012	Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid.	Chromium	33-41	interleukin 1 beta	Homo sapiens	144-152
21933296-3	2012	We show that a novel specific P2X(7)  receptor antagonist, GSK1370319A, inhibits ATP-induced increase in IL-1beta release and caspase 1 activation in lipopolysaccharide (LPS)-primed mixed glia by blocking assembly of the inflammasome in a pannexin 1-dependent manner.	GSK 1370319A	59-70	interleukin 1 beta	Homo sapiens	105-113
21933296-3	2012	We show that a novel specific P2X(7)  receptor antagonist, GSK1370319A, inhibits ATP-induced increase in IL-1beta release and caspase 1 activation in lipopolysaccharide (LPS)-primed mixed glia by blocking assembly of the inflammasome in a pannexin 1-dependent manner.	Adenosine Triphosphate	81-84	interleukin 1 beta	Homo sapiens	105-113
22808498-8	2012	Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid.	Chromium	53-61	interleukin 1 beta	Homo sapiens	144-152
22808498-8	2012	Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid.	Nickel	62-68	interleukin 1 beta	Homo sapiens	144-152
22236141-12	2012	Treatment with oxLDL-IC induced the formation and release of HSP70-containing and IL-1beta-containing exosomes via an ASMase-dependent mechanism.	oxldl-ic	15-23	interleukin 1 beta	Homo sapiens	82-90
22273691-9	2012	Expression of MMP-13 was elevated in IL-1beta-stimulated C28/I2 cells following anti-miRNA-140 oligonucleotide transfection.	Oligonucleotides	95-110	interleukin 1 beta	Homo sapiens	37-45
22294087-5	2012	Cell death of JEG-3 cells in response to IL-1beta was significantly decreased by co-treatment with 100 nM and 1000 nM progesterone and completely abolished at a progesterone concentration of 1000 nM.	Progesterone	118-130	interleukin 1 beta	Homo sapiens	41-49
22273691-10	2012	NF-kappaB activity was inhibited in DHMEQ treated IL-1beta-stimulated C28/I2 cells and was associated with decreased miRNA-140 and MMP-13 expression.	dehydroxymethylepoxyquinomicin	36-41	interleukin 1 beta	Homo sapiens	50-58
22294087-5	2012	Cell death of JEG-3 cells in response to IL-1beta was significantly decreased by co-treatment with 100 nM and 1000 nM progesterone and completely abolished at a progesterone concentration of 1000 nM.	Progesterone	161-173	interleukin 1 beta	Homo sapiens	41-49
22311128-3	2012	The cytokines, interleukin-1 beta and tumor necrosis factor alpha, regulate transcription of a number of genes within the brain, which can lead to the formation of pro-inflammatory products of the arachidonic acid cascade.	Arachidonic Acid	197-213	interleukin 1 beta	Homo sapiens	15-65
22490786-7	2012	Treatment with FK866 (10 mg/kg), the best known and characterized NAMPT inhibitor, at 1 h and 6 h after SCI rescued motor function, preserved perilesional gray and white matter, restored anti-apoptotic and neurotrophic factors, prevented the activation of neutrophils, microglia and astrocytes and inhibited the elevation of NAMPT, PAR, TNF-alpha, IL-1beta, Bax expression and NF-kappaB activity.We show for the first time that FK866, a specific inhibitor of NAMPT, administered after SCI, is capable of reducing the secondary inflammatory injury and partly reduce permanent damage.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	15-20	interleukin 1 beta	Homo sapiens	348-356
22226662-7	2012	Changes in the concentration of plasma total carotenoid and beta-carotene were inversely correlated with change in plasma IL-1beta concentration.	Carotenoids	45-55	interleukin 1 beta	Homo sapiens	122-130
22226662-7	2012	Changes in the concentration of plasma total carotenoid and beta-carotene were inversely correlated with change in plasma IL-1beta concentration.	beta Carotene	60-73	interleukin 1 beta	Homo sapiens	122-130
22246000-0	2012	Ciclesonide inhibits TNFalpha- and IL-1beta-induced monocyte chemotactic protein-1 (MCP-1/CCL2) secretion from human airway smooth muscle cells.	ciclesonide	0-11	interleukin 1 beta	Homo sapiens	35-43
22246000-9	2012	Formoterol had no effect on MCP-1 expression, while ciclesonide significantly inhibited IL-1beta- and TNFalpha-induced MCP-1.	ciclesonide	52-63	interleukin 1 beta	Homo sapiens	88-96
22246000-10	2012	Furthermore, ciclesonide inhibited IL-1beta- and TNFalpha-induced MCP-1 mRNA and IL-1beta- and TNFalpha-induced MCP-1 promoter and enhancer luciferase reporters.	ciclesonide	13-24	interleukin 1 beta	Homo sapiens	35-43
22246000-10	2012	Furthermore, ciclesonide inhibited IL-1beta- and TNFalpha-induced MCP-1 mRNA and IL-1beta- and TNFalpha-induced MCP-1 promoter and enhancer luciferase reporters.	ciclesonide	13-24	interleukin 1 beta	Homo sapiens	81-89
22353746-1	2012	OBJECTIVE: Selenium neutralizes interleukin-1beta (IL-1beta) induced inflammatory responses in chondrocytes.	Selenium	11-19	interleukin 1 beta	Homo sapiens	32-49
22353746-1	2012	OBJECTIVE: Selenium neutralizes interleukin-1beta (IL-1beta) induced inflammatory responses in chondrocytes.	Selenium	11-19	interleukin 1 beta	Homo sapiens	51-59
22322153-7	2012	PFOA induced gene expression of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in mast cells.	perfluorooctanoic acid	0-4	interleukin 1 beta	Homo sapiens	102-124
22306363-6	2012	These results confirmed that PGE(2) mediates the effects of ATRA on HIF-1alpha expression; iii) Prostaglandin uptake transporter inhibitor bromocresol green blocked the increase in HIF-1alpha expression induced by PGE(2) or by PGE(2)-increasing cytokine interleukin-1beta, but not by ATRA.	Prostaglandins	96-109	interleukin 1 beta	Homo sapiens	254-271
22268118-5	2012	ASMC stimulation with IL-1beta, TNF-alpha, and IFNgamma (cytomix) induced the highest level of syndecan-4 shedding.	asmc	0-4	interleukin 1 beta	Homo sapiens	22-30
22275753-9	2012	In addition, 25HC3S decreased LPS-induced expression and release of IL-1beta.	25-hydroxycholesterol 3-sulfate	13-19	interleukin 1 beta	Homo sapiens	68-76
22387385-6	2012	Moreover, vitamin D3 significantly reduced the levels of proinflammatory cytokines (TNF-alpha, IL-6, IL-12p70 and IL-1beta) produced by infected U937 cells.	Cholecalciferol	10-20	interleukin 1 beta	Homo sapiens	114-122
22306153-5	2012	RESULTS: Minocycline significantly reduced the inflammatory response in LPS-challenged monocytes, decreasing LPS-induced transcription of pro-inflammatory tumor-necrosis factor alpha (TNF-alpha), interleukin-1 beta, interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2), and the LPS-stimulated TNF-alpha, IL-6 and PGE(2) release.	Minocycline	9-20	interleukin 1 beta	Homo sapiens	196-214
22306363-6	2012	These results confirmed that PGE(2) mediates the effects of ATRA on HIF-1alpha expression; iii) Prostaglandin uptake transporter inhibitor bromocresol green blocked the increase in HIF-1alpha expression induced by PGE(2) or by PGE(2)-increasing cytokine interleukin-1beta, but not by ATRA.	Bromcresol Green	139-156	interleukin 1 beta	Homo sapiens	254-271
22306363-6	2012	These results confirmed that PGE(2) mediates the effects of ATRA on HIF-1alpha expression; iii) Prostaglandin uptake transporter inhibitor bromocresol green blocked the increase in HIF-1alpha expression induced by PGE(2) or by PGE(2)-increasing cytokine interleukin-1beta, but not by ATRA.	Prostaglandins E	214-217	interleukin 1 beta	Homo sapiens	254-271
22306363-6	2012	These results confirmed that PGE(2) mediates the effects of ATRA on HIF-1alpha expression; iii) Prostaglandin uptake transporter inhibitor bromocresol green blocked the increase in HIF-1alpha expression induced by PGE(2) or by PGE(2)-increasing cytokine interleukin-1beta, but not by ATRA.	Prostaglandins E	214-217	interleukin 1 beta	Homo sapiens	254-271
21959683-4	2012	Our findings included an immediate plasmatic reduction in IL-1, IL-10, and TNF-alpha levels in doxorubicin-treated patients, as well as high levels of IL-10 in paclitaxel patients.	Doxorubicin	95-106	interleukin 1 beta	Homo sapiens	58-62
21959683-6	2012	In vitro analysis was performed exposing healthy blood to both chemotherapics in the same concentration and time of exposition of patients, resulting in low IL-10 and high IL-1beta in doxorubicin exposition, as low TNF-alpha and high IL-1 in paclitaxel treatment.	Doxorubicin	184-195	interleukin 1 beta	Homo sapiens	172-180
22515414-10	2012	Furthermore, PA induced caspase-1 activation in a dose-dependent manner, resulting in exacerbating of procaspase-1 and pro-IL-1beta processing.	Palmitates	13-15	interleukin 1 beta	Homo sapiens	119-131
22515414-11	2012	Knockdown of NLRC4 partially abrogated PA-induced caspase-1 activation and IL-1beta maturation and completely abolished these events in the presence of DHA.	Palmitates	39-41	interleukin 1 beta	Homo sapiens	75-83
22515414-12	2012	CONCLUSIONS: Our findings indicate DHA attenuates PA-induced lipid accumulation and inflammation through suppressing NLRC4 inflammasome activation, caspase-1 activation and IL-1beta cleavage.	Docosahexaenoic Acids	35-38	interleukin 1 beta	Homo sapiens	173-181
22515414-12	2012	CONCLUSIONS: Our findings indicate DHA attenuates PA-induced lipid accumulation and inflammation through suppressing NLRC4 inflammasome activation, caspase-1 activation and IL-1beta cleavage.	Palmitates	50-52	interleukin 1 beta	Homo sapiens	173-181
22436237-9	2012	Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells.	Reactive Oxygen Species	31-54	interleukin 1 beta	Homo sapiens	160-177
22436237-9	2012	Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells.	Nitric Oxide	59-71	interleukin 1 beta	Homo sapiens	160-177
22436237-9	2012	Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells.	2',7'-dichlorofluorescein	73-92	interleukin 1 beta	Homo sapiens	160-177
22436237-9	2012	Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells.	diaminofluorescein	97-115	interleukin 1 beta	Homo sapiens	160-177
22436237-9	2012	Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells.	Nitric Oxide	245-257	interleukin 1 beta	Homo sapiens	160-177
22436237-11	2012	Pharmacological inhibition of inducible nitric oxide synthase by 1400W reduced intracellular production of nitric oxide and prevented accumulation of beta-amyloid, nitration of tyrosine as well as cell death inflicted by interleukin-1beta combined with interferon-gamma.	nitric	40-46	interleukin 1 beta	Homo sapiens	221-238
22436237-11	2012	Pharmacological inhibition of inducible nitric oxide synthase by 1400W reduced intracellular production of nitric oxide and prevented accumulation of beta-amyloid, nitration of tyrosine as well as cell death inflicted by interleukin-1beta combined with interferon-gamma.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	65-70	interleukin 1 beta	Homo sapiens	221-238
22436237-11	2012	Pharmacological inhibition of inducible nitric oxide synthase by 1400W reduced intracellular production of nitric oxide and prevented accumulation of beta-amyloid, nitration of tyrosine as well as cell death inflicted by interleukin-1beta combined with interferon-gamma.	Nitric Oxide	40-52	interleukin 1 beta	Homo sapiens	221-238
22119425-11	2012	IL-1beta was decreased in LPS-stimulated human microglia following propentofylline at 100 muM.	propentofylline	67-82	interleukin 1 beta	Homo sapiens	0-8
22274300-4	2012	We investigated the influence of fenofibrate on IL-1beta-stimulated production of ENA-78 and IL-8 from human endothelial cells (HUVECs).	Fenofibrate	33-44	interleukin 1 beta	Homo sapiens	48-56
22274300-13	2012	CONCLUSIONS: Fenofibrate blunts IL-1beta-mediated ENA-78 production with no effect on IL-8.	Fenofibrate	13-24	interleukin 1 beta	Homo sapiens	32-40
22333895-4	2012	The level of cAMP stimulated by IL-1beta on different times was investigated by radioimmunoassay, and the activity of PKA was measured by luminescent kinase assay.	Cyclic AMP	13-17	interleukin 1 beta	Homo sapiens	32-40
22487368-5	2012	Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-alpha, interleukin-1beta (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	198-215
22454545-5	2012	Cells exposed to PBDEs released significantly less pro-inflammatory cytokines (TNF-alpha and IL-6) and PGE(2) compared with controls; IL-1beta and IL-10 were not detected in the culture medium.	Halogenated Diphenyl Ethers	17-22	interleukin 1 beta	Homo sapiens	134-142
22665731-2	2012	To beginning of the treatment at intensifying of CS at the patients was detected the substantial increase of maintenance of proinflammatory (IL - 1beta, IL - 2, IL - 6, TNF -alpha) cytokines (CK) in the blood serum at the moderate increase of antiinflammatory CK (IL-4).	Cesium	49-51	interleukin 1 beta	Homo sapiens	141-151
21556735-0	2012	Farnesyltransferase inhibitor manumycin targets IL1beta-Ras-HIF-1alpha axis in tumor cells of diverse origin.	manumycin	30-39	interleukin 1 beta	Homo sapiens	48-55
21556735-5	2012	As we have previously reported that the farnesyltransferase inhibitor manumycin decreases Ras activity in glioma cells, we investigated whether manumycin could regulate IL-1beta-mediated HIF-1alpha activation.	manumycin	144-153	interleukin 1 beta	Homo sapiens	169-177
21556735-6	2012	Manumycin abrogated IL-1beta-induced HIF-1alpha activation in both glioma and non-glioma tumor cells.	manumycin	0-9	interleukin 1 beta	Homo sapiens	20-28
21556735-7	2012	In addition, manumycin also decreased IL-1beta induced pro-inflammatory responses in tumor cells.	manumycin	13-22	interleukin 1 beta	Homo sapiens	38-46
22333895-6	2012	We found that the human FLS proliferation increased apparently in 24 h, and the activities of PKA and cAMP accumulation increased significantly in 6 h after stimulated by IL-1beta, while cAMP accumulation and the activities of PKA decreased especially in 24 h when the expression of beta-arrestin 2 increased significantly.	Cyclic AMP	102-106	interleukin 1 beta	Homo sapiens	171-179
21951103-5	2012	On the other hand, melatonin regulates circadian rhythm homeostasis in humans and has many other effects, which include antioxidant and anti-inflammatory effects, as demonstrated by the reduced expressions of iNOS, IL-1beta, and IL-6 and increased glutathione (GSH) and superoxide dismutase activities.	Melatonin	19-28	interleukin 1 beta	Homo sapiens	215-223
22697068-4	2012	Indeed, differentiated THP-1 cell exposures (i) to 5 and 10 microM of combination of NP and DiP induced an IL-8 level in the medium respectively of 28.9 and 45 percent higher than the level obtained for the control (untreated cells), (ii) to combination of NP and DiP at 10 microM induced an increase of IL-1beta level in comparison to the control level, (iii) to combination of NP and DiP induced an increase of TNF-alpha level whatever the concentration of EDCs tested (between 0 and 10 microM).	diisononyl phthalate	92-95	interleukin 1 beta	Homo sapiens	304-312
22113347-8	2012	In the tumor necrosis factor-alpha-treated human umbilical vein endothelial cell line, incubation with MTX led to downregulation of 5 pro-inflammatory genes, TNF-alpha, VAP-1, IL-1beta, CXCL2, and TLR2, and upregulation of the anti-inflammatory TGF-beta1 gene, thus showing endothelium-protective properties.	Methotrexate	103-106	interleukin 1 beta	Homo sapiens	176-184
22213141-6	2012	Dietary sodium deficiency, a manipulation that prevents macrophage recruitment, inhibits the elevation in IL-1beta.	Sodium	8-14	interleukin 1 beta	Homo sapiens	106-114
22193459-8	2012	Mitoxantrone accumulation was also amplified in IL-1beta-, IL-6- or TNF-alpha-treated HeLa cells and in IL-1beta-treated EPG85-257 cells.	Mitoxantrone	0-12	interleukin 1 beta	Homo sapiens	48-56
22228809-5	2012	Suramin treatment decreased interleukin-1beta (IL-1beta) mRNA, transforming growth factor-beta(1) (TGF-beta(1)), phospho-p65 of nuclear factor-kappaB (NF-kappaB), and cleaved caspase-3 at 48 h compared with glycerol alone.	Suramin	0-7	interleukin 1 beta	Homo sapiens	28-45
22228809-5	2012	Suramin treatment decreased interleukin-1beta (IL-1beta) mRNA, transforming growth factor-beta(1) (TGF-beta(1)), phospho-p65 of nuclear factor-kappaB (NF-kappaB), and cleaved caspase-3 at 48 h compared with glycerol alone.	Suramin	0-7	interleukin 1 beta	Homo sapiens	47-55
22395218-3	2012	In this study, we sought to investigate the association of both patient and donor genotypes at the IL-1beta -511 cytidine/thymidine (C/T) polymorphic site with hepatic VOD and mortality in an exclusive pediatric cohort undergoing matched myeloablative allogeneic HSCT.	Cytidine	113-121	interleukin 1 beta	Homo sapiens	99-107
22193459-8	2012	Mitoxantrone accumulation was also amplified in IL-1beta-, IL-6- or TNF-alpha-treated HeLa cells and in IL-1beta-treated EPG85-257 cells.	Mitoxantrone	0-12	interleukin 1 beta	Homo sapiens	104-112
22079797-0	2012	Oral administration of docosahexaenoic acid attenuates interleukin-1beta response and clinical course of septic neonates.	Docosahexaenoic Acids	23-43	interleukin 1 beta	Homo sapiens	55-72
22079797-9	2012	Although decreases of cytokines during hospitalization were similar in both groups, there was a greater decrease of IL-1beta in the G-DHA group than in the G-OO group after adjusting by confounders (P = 0.028).	dehydroacetic acid	134-137	interleukin 1 beta	Homo sapiens	116-124
22079797-12	2012	CONCLUSIONS: Oral supplementation with docosahexaenoic acid to neonates attenuates IL-1beta response and the clinical course of sepsis.	Docosahexaenoic Acids	39-59	interleukin 1 beta	Homo sapiens	83-91
22342844-5	2012	Both binding of oxidized mtDNA to the NLRP3 inflammasome and IL-1beta secretion could be competitively inhibited by the oxidized nucleoside 8-OH-dG.	Nucleosides	129-139	interleukin 1 beta	Homo sapiens	61-69
22690149-5	2012	ELISA measurement suggested that ASTA treatment (10 microM) reduced pro-inflammatory cytokines secretion (IL-1beta, IL-6 and TNF-alpha) induced through H(2)O(2), (100 microM).	Cyclophosphamide	33-37	interleukin 1 beta	Homo sapiens	106-114
22064970-7	2012	Calcitriol also reduced interleukin (IL)-1beta-induced expression of MMP-1 by 95% in DA FLSs and by 73.5% in RA FLS.	Calcitriol	0-10	interleukin 1 beta	Homo sapiens	24-46
22342844-5	2012	Both binding of oxidized mtDNA to the NLRP3 inflammasome and IL-1beta secretion could be competitively inhibited by the oxidized nucleoside 8-OH-dG.	8-ohdg	140-147	interleukin 1 beta	Homo sapiens	61-69
22323467-7	2012	The induction of FGF-2 by IL-1beta was completely blocked by inhibitors to NF-kappaB activation (sulfasalazine) or PI 3-kinase (LY294002), and both inhibitors greatly blocked cell proliferation of CECs.	Sulfasalazine	97-110	interleukin 1 beta	Homo sapiens	26-34
22323467-7	2012	The induction of FGF-2 by IL-1beta was completely blocked by inhibitors to NF-kappaB activation (sulfasalazine) or PI 3-kinase (LY294002), and both inhibitors greatly blocked cell proliferation of CECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	interleukin 1 beta	Homo sapiens	26-34
22289904-6	2012	RESULTS: Pretreatment with dexamethasone led to a significant decrease in myocardial expression of IL-6, IL-8, IL-1beta, and TNF-alpha messenger RNA and to a decrease in protein synthesis of TNF-alpha.	Dexamethasone	27-40	interleukin 1 beta	Homo sapiens	111-119
22252128-3	2012	We found that after photodynamic therapy (PDT), which generates ROS-mediated ER stress, dying cancer cells undergo immunogenic apoptosis characterized by phenotypic maturation (CD80(high), CD83(high), CD86(high), MHC-II(high)) and functional stimulation (NO(high), IL-10(absent), IL-1beta(high)) of dendritic cells as well as induction of a protective antitumour immune response.	Reactive Oxygen Species	64-67	interleukin 1 beta	Homo sapiens	280-288
21953341-9	2012	TSA induced a significant reduction in nuclear retention of NFkappaB in FLS 24 h after IL-1beta stimulation, but this did not reduce NFkappaB transcriptional activity or correlate temporally with reductions in IL-6 mRNA accumulation.	trichostatin A	0-3	interleukin 1 beta	Homo sapiens	87-95
22281291-3	2012	After finding a connection between interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1Ra) in caerulein-induced chronic pancreatitis, we assumed that recombinant human IL-1Ra (rhIL-1Ra), the natural antagonist of IL-1beta, might have a protective role in chronic pancreatitis in mice.	Ceruletide	114-123	interleukin 1 beta	Homo sapiens	54-62
22155370-1	2012	In the intestine, NF-kappaB is the main transcription factor involved in the anti-inflammatory effect of glutamine and we previously demonstrated that glutamine via its conversion to glutamate diminished the p65 protein content in Caco-2/TC7 cell nuclei without affecting the stimulating effect of IL-1beta on NF-kappaB [21].	Glutamine	151-160	interleukin 1 beta	Homo sapiens	298-306
22155370-1	2012	In the intestine, NF-kappaB is the main transcription factor involved in the anti-inflammatory effect of glutamine and we previously demonstrated that glutamine via its conversion to glutamate diminished the p65 protein content in Caco-2/TC7 cell nuclei without affecting the stimulating effect of IL-1beta on NF-kappaB [21].	Glutamic Acid	183-192	interleukin 1 beta	Homo sapiens	298-306
21889590-6	2012	Homozygotes for IL-1beta-511T allele and carriers of CRP-286T allele that are associated with increased inflammatory response had larger WMH than the other allelic combinations.	1-methyl-1H-1,2,3-triazole	137-140	interleukin 1 beta	Homo sapiens	16-24
21954917-4	2012	Treatment with the HO-1 inducer CoPP (cobalt protoporphyrin IX) counteracted the stimulatory effects of IL-1beta on IL-6, nitrite, PGE2 (prostaglandin E2), TGF (transforming growth factor) beta2, TGFbeta3 and osteocalcin.	cobaltiprotoporphyrin	38-62	interleukin 1 beta	Homo sapiens	104-112
21954917-4	2012	Treatment with the HO-1 inducer CoPP (cobalt protoporphyrin IX) counteracted the stimulatory effects of IL-1beta on IL-6, nitrite, PGE2 (prostaglandin E2), TGF (transforming growth factor) beta2, TGFbeta3 and osteocalcin.	Nitrites	122-129	interleukin 1 beta	Homo sapiens	104-112
21954917-4	2012	Treatment with the HO-1 inducer CoPP (cobalt protoporphyrin IX) counteracted the stimulatory effects of IL-1beta on IL-6, nitrite, PGE2 (prostaglandin E2), TGF (transforming growth factor) beta2, TGFbeta3 and osteocalcin.	Dinoprostone	131-135	interleukin 1 beta	Homo sapiens	104-112
21848430-9	2012	However, in presence of doxycycline, inhibition of cytokines (IL-1beta and IL-6) was only observed in stimulated cells from fertile women with primary C. trachomatis infection.	Doxycycline	24-35	interleukin 1 beta	Homo sapiens	62-70
22182686-10	2012	Finally, calcitriol inhibited TNF-alpha and IL-1beta stimulation upon IL-10.	Calcitriol	9-19	interleukin 1 beta	Homo sapiens	44-52
22179411-0	2012	BAI, a 3-aminoindazole derivative, inhibits interleukin-1beta-induced expression             of cyclooxygenase-2 in A549 human airway cells.	1H-Indazol-3-amine	7-22	interleukin 1 beta	Homo sapiens	44-61
22105559-0	2012	Sphingosine regulates the NLRP3-inflammasome and IL-1beta release from macrophages.	Sphingosine	0-11	interleukin 1 beta	Homo sapiens	49-57
22105559-4	2012	Here, we show that the endogenous lipid metabolite sphingosine (Sph) acts as a DAMP by inducing the NLRP3-inflammasome-dependent secretion of IL-1beta from macrophages.	Sphingosine	51-62	interleukin 1 beta	Homo sapiens	142-150
22105559-4	2012	Here, we show that the endogenous lipid metabolite sphingosine (Sph) acts as a DAMP by inducing the NLRP3-inflammasome-dependent secretion of IL-1beta from macrophages.	Sphingosine	64-67	interleukin 1 beta	Homo sapiens	142-150
22105559-5	2012	This process was dependent upon serine/threonine protein phosphatases since the PP1/PP2A inhibitors okadaic acid and calyculin A inhibited Sph-induced IL-1beta release.	Okadaic Acid	100-112	interleukin 1 beta	Homo sapiens	151-159
22105559-5	2012	This process was dependent upon serine/threonine protein phosphatases since the PP1/PP2A inhibitors okadaic acid and calyculin A inhibited Sph-induced IL-1beta release.	calyculin A	117-128	interleukin 1 beta	Homo sapiens	151-159
22105559-5	2012	This process was dependent upon serine/threonine protein phosphatases since the PP1/PP2A inhibitors okadaic acid and calyculin A inhibited Sph-induced IL-1beta release.	Sphingosine	139-142	interleukin 1 beta	Homo sapiens	151-159
22105559-6	2012	IL-1beta release induced by other well-characterized NLRP3-inflammasome activators, such as ATP and uric acid crystals, in addition to NLRC4 and AIM2 inflammasome activators was also blocked by these inhibitors.	Adenosine Triphosphate	92-95	interleukin 1 beta	Homo sapiens	0-8
22105559-6	2012	IL-1beta release induced by other well-characterized NLRP3-inflammasome activators, such as ATP and uric acid crystals, in addition to NLRC4 and AIM2 inflammasome activators was also blocked by these inhibitors.	Uric Acid	100-109	interleukin 1 beta	Homo sapiens	0-8
22179411-2	2012	In this study, we have assessed the pharmacological characteristics             of BAI, a 3-aminoindazole derivative and a novel cyclin-dependent kinase (CDK)             inhibitor, for regulation of COX-2 expression induced by interleukin (IL)-1beta in             A549 human airway cells.	1H-Indazol-3-amine	90-105	interleukin 1 beta	Homo sapiens	228-250
21550286-0	2012	Tacrolimus (FK506) inhibits interleukin-1beta-induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes.	Tacrolimus	0-10	interleukin 1 beta	Homo sapiens	28-45
21550286-0	2012	Tacrolimus (FK506) inhibits interleukin-1beta-induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes.	Tacrolimus	12-17	interleukin 1 beta	Homo sapiens	28-45
22401590-3	2012	We present heuristic and exact optimization algorithms, and we report on some computational experiments on amino peptides taken from Semaphorin and human Interleukin-1beta, which have already been investigated in the literature using heuristic algorithms.	amino peptides	107-121	interleukin 1 beta	Homo sapiens	154-171
22071871-0	2012	Interleukin-1beta: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis.	Kynurenine	42-52	interleukin 1 beta	Homo sapiens	0-17
21952131-5	2012	URB597 attenuated the LPS-induced increase in interleukin (IL)-1beta expression while concurrently augmenting the LPS-induced increase in suppressor of cytokine signalling (SOCS)-3 expression.	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	0-6	interleukin 1 beta	Homo sapiens	46-68
21550286-1	2012	OBJECT: This study aimed to identify the regulatory effect of tacrolimus on the interleukin-1beta (IL-1beta)-induced expressions of angiopoietin-1 (Ang-1), Tie-2 receptor (Tie-2), and vascular endothelial growth factor (VEGF) in human rheumatoid fibroblast-like synoviocytes (FLS) and to determine the regulatory mechanism in the mitogen-activated protein kinases (MAPKs) signaling pathway.	Tacrolimus	62-72	interleukin 1 beta	Homo sapiens	80-97
21550286-1	2012	OBJECT: This study aimed to identify the regulatory effect of tacrolimus on the interleukin-1beta (IL-1beta)-induced expressions of angiopoietin-1 (Ang-1), Tie-2 receptor (Tie-2), and vascular endothelial growth factor (VEGF) in human rheumatoid fibroblast-like synoviocytes (FLS) and to determine the regulatory mechanism in the mitogen-activated protein kinases (MAPKs) signaling pathway.	Tacrolimus	62-72	interleukin 1 beta	Homo sapiens	99-107
21550286-2	2012	METHODS: IL-1beta-induced Ang-1, Tie-2, and VEGF expressions with and without tacrolimus were measured in cultured FLS using real time-polymerase chain reaction, enzyme-linked immunosorbent assay, Western blotting, and immunofluorescence staining.	Tacrolimus	78-88	interleukin 1 beta	Homo sapiens	9-17
21550286-5	2012	Tacrolimus significantly inhibited Ang-1, Tie-2, and VEGF mRNA and protein in cultured FLS treated with 10 ng/ml IL-1beta.	Tacrolimus	0-10	interleukin 1 beta	Homo sapiens	113-121
21550286-8	2012	CONCLUSION: This study demonstrates that tacrolimus inhibits the expressions of Ang-1, Tie-2, and VEGF by blocking the activations of the IL-1beta-mediated JNK and p38 MAPK pathways in human FLS.	Tacrolimus	41-51	interleukin 1 beta	Homo sapiens	138-146
22071871-4	2012	Analysis of the enzymes that regulate the kynurenine pathway showed that IL-1beta induced an upregulation of transcripts for indolamine-2,3-dioxygenase (IDO), kynurenine 3-monooxygenase (KMO), and kynureninase (42-, 12- and 30-fold increase, respectively, under differentiating conditions), the enzymes involved in the neurotoxic arm of the kynurenine pathway.	Kynurenine	159-169	interleukin 1 beta	Homo sapiens	73-81
22071871-5	2012	Moreover, treatment with IL-1beta resulted in an increase in kynurenine, the catabolic product of IDO-induced tryptophan metabolism.	Kynurenine	61-71	interleukin 1 beta	Homo sapiens	25-33
22071871-4	2012	Analysis of the enzymes that regulate the kynurenine pathway showed that IL-1beta induced an upregulation of transcripts for indolamine-2,3-dioxygenase (IDO), kynurenine 3-monooxygenase (KMO), and kynureninase (42-, 12- and 30-fold increase, respectively, under differentiating conditions), the enzymes involved in the neurotoxic arm of the kynurenine pathway.	Kynurenine	42-52	interleukin 1 beta	Homo sapiens	73-81
21161531-8	2012	The data provided prove that in these cells, constitutive as well as IL-1beta-induced IL-6 and IL-8 expression was partially and transiently blocked by the treatment of cells with both MAPK inhibitors and NaHS.	SODIUM HYDROSULFIDE	205-209	interleukin 1 beta	Homo sapiens	69-77
22071871-5	2012	Moreover, treatment with IL-1beta resulted in an increase in kynurenine, the catabolic product of IDO-induced tryptophan metabolism.	Tryptophan	110-120	interleukin 1 beta	Homo sapiens	25-33
22071871-6	2012	Interestingly, co-treatment with the KMO inhibitor Ro 61-8048 reversed the detrimental effects of IL-1beta on neurogenesis.	Ro 61-8048	51-61	interleukin 1 beta	Homo sapiens	98-106
22071871-7	2012	These observations indicate that IL-1beta has a critical role in regulating neurogenesis whereas affecting the availability of tryptophan and the production of enzymes conducive to toxic metabolites.	Tryptophan	127-137	interleukin 1 beta	Homo sapiens	33-41
22064385-0	2012	Interleukin 1beta regulates progesterone metabolism in human cervical fibroblasts.	Progesterone	28-40	interleukin 1 beta	Homo sapiens	0-17
22064385-9	2012	Interleukin 1beta treatment significantly increased progesterone metabolism by these cells.	Progesterone	52-64	interleukin 1 beta	Homo sapiens	0-17
22064385-11	2012	Our results indicate that a major proinflammatory cytokine, IL-1beta, can facilitate local progesterone metabolism in a cell type critical for maintaining cervical structure via regulating expression of AKR1C1 and 2.	Progesterone	91-103	interleukin 1 beta	Homo sapiens	60-68
21161531-0	2012	Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.	Hydrogen Sulfide	43-60	interleukin 1 beta	Homo sapiens	84-92
22611924-1	2012	OBJECTIVE: To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells (HUVECs).	citreoviridin	41-54	interleukin 1 beta	Homo sapiens	89-97
22611924-1	2012	OBJECTIVE: To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells (HUVECs).	citreoviridin	56-59	interleukin 1 beta	Homo sapiens	89-97
22611924-6	2012	CONCLUSION: The expression of NF-kappaB, MCP-1, IL-1beta, IL-6 and IL-8 in HUVECs up-regulated by TNF-alpha was promoted by CIT.	citreoviridin	124-127	interleukin 1 beta	Homo sapiens	48-56
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	Chromium	102-104	interleukin 1 beta	Homo sapiens	112-129
22365665-4	2012	In the absence of IAPs, rapid and full generation of active IL-1beta by the NLRP3-caspase-1 inflammasome, or by caspase-8, required the kinase RIP3 and reactive oxygen species production.	Reactive Oxygen Species	152-175	interleukin 1 beta	Homo sapiens	60-68
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	ni &gt	201-207	interleukin 1 beta	Homo sapiens	112-129
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	ni &gt	201-207	interleukin 1 beta	Homo sapiens	130-138
22335964-6	2012	Minocycline, an inhibitor of activated MPs, decreased TNF-alpha expression in CD14+ cells and IL-1beta release in PBMCs of HAM/TSP patients.	Minocycline	0-11	interleukin 1 beta	Homo sapiens	94-102
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	Creatinine	227-237	interleukin 1 beta	Homo sapiens	112-129
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	Creatinine	227-237	interleukin 1 beta	Homo sapiens	130-138
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	Creatinine	297-307	interleukin 1 beta	Homo sapiens	112-129
22800666-3	2012	RESULTS: After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr, serum interleukin-1beta(IL-1beta) was found to be significantly higher in the group of urinary Ni &gt; 115.73 microg/mol creatinine comparing to the group of urinary Ni &lt; 37.28 microg/mol creatinine (P &lt; 0.05).	Creatinine	297-307	interleukin 1 beta	Homo sapiens	130-138
21989538-10	2012	Upon activation, the IL-1 receptor antagonist (IL-1Ra)/IL-1beta ratio was higher in AAT than in SM cultures.	o-Aminoazotoluene	84-87	interleukin 1 beta	Homo sapiens	55-63
22309647-0	2012	Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1beta-activated human mast cells were inhibited by Baicalein via regulation of the NF-kappaB pathway.	baicalein	137-146	interleukin 1 beta	Homo sapiens	83-91
21998115-10	2012	Moreover, when catabolic conditions were enhanced with interleukin 1beta, FCM inhibited NO production as well as MMP1 and MMP3 gene expression and increased collagen type II gene expression.	Fosfomycin	74-77	interleukin 1 beta	Homo sapiens	55-72
22155150-6	2012	In addition, oridonin increased the protein levels of p-ERK, NF-kappaB, caspase-1 and pro IL-1beta.	oridonin	13-21	interleukin 1 beta	Homo sapiens	90-98
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	21-36	interleukin 1 beta	Homo sapiens	163-171
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	38-42	interleukin 1 beta	Homo sapiens	163-171
22155150-11	2012	These results demonstrated that autophagy enhanced oridonin-induced phagocytosis through feedback regulation of ERK, NF-kappaB- and caspase-1-mediated IL-1beta release.	oridonin	51-59	interleukin 1 beta	Homo sapiens	151-159
21928330-8	2012	Similarly, glycation of HDL in vitro impaired its ability to inhibit TNF-alpha and IL-1beta release in a glucose dose-dependent manner.	Glucose	105-112	interleukin 1 beta	Homo sapiens	83-91
22045316-6	2012	Compared with placebo, DHEA administration raised levels of testosterone, androstenedione, and DHEA-S, increased the percent change in fasting and glucose-challenged activated NF-kappaB, p65, p105, TNFalpha, and IL-1beta RNA and p65 protein, and decreased the percent change in fasting and glucose-challenged IkappaB protein.	Dehydroepiandrosterone	23-27	interleukin 1 beta	Homo sapiens	212-220
22368729-4	2012	More recently, emphasis has been placed on the elucidation of the mechanisms that contribute to pro-IL-1beta production and finally its processing via multiprotein complexes termed the inflammasomes, a family of cytosolic multiprotein complexes that serve as sensors of either pathogen invasion or cellular stress (ie, cholesterol crystals) and work via triggering caspase-1-mediated processing of pro-IL-1beta to IL-1beta.	Cholesterol	319-330	interleukin 1 beta	Homo sapiens	96-108
22045316-6	2012	Compared with placebo, DHEA administration raised levels of testosterone, androstenedione, and DHEA-S, increased the percent change in fasting and glucose-challenged activated NF-kappaB, p65, p105, TNFalpha, and IL-1beta RNA and p65 protein, and decreased the percent change in fasting and glucose-challenged IkappaB protein.	Glucose	147-154	interleukin 1 beta	Homo sapiens	212-220
22030090-5	2012	Curcumin treatment inhibited the expansion of MDSCs, the activation of Stat3 and NF-kappaB in MDSCs, and the secretion of IL-6 by MDSCs, when MDSCs were cultured in the presence of IL-1beta, or with cancer cell- or myofibroblast-conditioned medium.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	181-189
22154780-6	2012	In fact, monocytes cultured at pH 6.5 undergo a fall in the values of intracellular pH while the inhibitor of the Na+/H+ exchanger, 5-(N-ethyl-N-isopropyl)amiloride induced both, a decrease in the values of intracellular pH and the stimulation of IL-1beta production.	ethylisopropylamiloride	132-164	interleukin 1 beta	Homo sapiens	247-255
22154780-7	2012	Real time quantitative PCR assays indicated that monocytes cultured either at pH 6.5 or in the presence of 5-(N-ethyl-N-isopropyl)amiloride expressed higher levels of pro-IL-1beta mRNA suggesting that low values of intracellular pH enhance the production of IL-1beta, at least in part, by stimulating the synthesis of its precursor.	ethylisopropylamiloride	107-139	interleukin 1 beta	Homo sapiens	167-179
22154780-7	2012	Real time quantitative PCR assays indicated that monocytes cultured either at pH 6.5 or in the presence of 5-(N-ethyl-N-isopropyl)amiloride expressed higher levels of pro-IL-1beta mRNA suggesting that low values of intracellular pH enhance the production of IL-1beta, at least in part, by stimulating the synthesis of its precursor.	ethylisopropylamiloride	107-139	interleukin 1 beta	Homo sapiens	171-179
22389976-0	2012	[Study on the expression of Toll like receptor 2 and interleukin-1 beta induced by Enterococcus faecalis lipoteichoic acid on human periodontal ligament cells].	lipoteichoic acid	105-122	interleukin 1 beta	Homo sapiens	53-71
22166980-6	2012	Whether IL-1beta and TGF-beta1 regulate Twist mRNA and protein levels in the EVT was also examined.	EVT	77-80	interleukin 1 beta	Homo sapiens	8-16
22166980-10	2012	IL-1beta and TGF-beta1 differentially regulated Twist expression in EVT in a time- and concentration-dependent manner.	EVT	68-71	interleukin 1 beta	Homo sapiens	0-8
22076019-12	2012	CONCLUSIONS: Atorvastatin treatment for 4 weeks in subjects with SCR significantly improved endothelial function and suppressed systemic inflammatory status by decreasing circulating levels of IL-1b and sVCAM-1.	Atorvastatin	13-25	interleukin 1 beta	Homo sapiens	193-198
22416219-7	2012	Ghrelin prevented THA-induced microglial activation in the spinal cord and the expression of pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta.	Ghrelin	0-7	interleukin 1 beta	Homo sapiens	152-169
21792602-7	2012	IL-1beta or TNF-alpha increased expression of MMP-9 and MMP-2 in rheumatoid synoviocytes; EGF stimulated expression of MMP-9 but not of MMP-2; genistein suppressed production of MMP-9 more than MMP-2 induced by IL-1beta or TNF-alpha; rMMP-9, rMMP-2, or their inhibitors had no effect on the (3)H-TdR incorporation of synovial cells.	Genistein	143-152	interleukin 1 beta	Homo sapiens	0-8
21792602-7	2012	IL-1beta or TNF-alpha increased expression of MMP-9 and MMP-2 in rheumatoid synoviocytes; EGF stimulated expression of MMP-9 but not of MMP-2; genistein suppressed production of MMP-9 more than MMP-2 induced by IL-1beta or TNF-alpha; rMMP-9, rMMP-2, or their inhibitors had no effect on the (3)H-TdR incorporation of synovial cells.	Genistein	143-152	interleukin 1 beta	Homo sapiens	211-219
21792602-8	2012	Erk1/2 inhibitor (PD098 059) had obvious inhibitory effect on the (3)H incorporation induced by TNF-alpha or IL-1beta; inhibitors of JNK (SP600 125) had no significant effect on the (3)H incorporation.	pd098 059	18-27	interleukin 1 beta	Homo sapiens	109-117
21792602-9	2012	While pretreatment with PD098059 had no marked inhibitory effect on MMP-9 expression induced by TNF-alpha or IL-1beta, SP600125 decreased significantly the MMP-9 expression induced by TNF-alpha or IL-1beta.	pyrazolanthrone	119-127	interleukin 1 beta	Homo sapiens	197-205
21792602-11	2012	Genistein inhibited IL-1beta, TNF-alpha or EGF-induced proliferation and MMP-9 expression in fibroblast-like synoviocytes of rheumatoid arthritis; the proliferation of RA-FLS was mediated by Erk1/2 but not JNK activation, while JNK activation was involved in the signal transduction pathway leading to MMP-9 expression in rheumatoid synoviocytes.	Genistein	0-9	interleukin 1 beta	Homo sapiens	20-28
22233829-10	2012	Significant correlations were found between estradiol and IL-10 in male patients, and between dehydroepiandrosterone (DHEA) and IL-1beta, and androstenedione and IL-17 in female patients.	Dehydroepiandrosterone	94-116	interleukin 1 beta	Homo sapiens	128-136
22233829-10	2012	Significant correlations were found between estradiol and IL-10 in male patients, and between dehydroepiandrosterone (DHEA) and IL-1beta, and androstenedione and IL-17 in female patients.	Dehydroepiandrosterone	118-122	interleukin 1 beta	Homo sapiens	128-136
22244821-0	2012	Morin inhibits interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.	Nitric Oxide	41-53	interleukin 1 beta	Homo sapiens	15-32
22244821-0	2012	Morin inhibits interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.	Dinoprostone	58-74	interleukin 1 beta	Homo sapiens	15-32
21792602-6	2012	Genistein had an inhibitory role on cell number and (3)H-TdR incorporation of RA-FLS stimulated with IL-1beta, TNF-alpha and EGF; genistein arrested the cell cycle at G(1) restriction point; genistein decreased colony numbers under anchorage-independent condition stimulated by EGF in serum condition.	Genistein	0-9	interleukin 1 beta	Homo sapiens	101-109
22158433-7	2012	Ramipril increased IL-1beta concentrations (P=0.02) and decreased IL-10 concentrations (P=0.04) compared with placebo.	Ramipril	0-8	interleukin 1 beta	Homo sapiens	19-27
22416219-7	2012	Ghrelin prevented THA-induced microglial activation in the spinal cord and the expression of pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta.	tha	18-21	interleukin 1 beta	Homo sapiens	152-169
22094458-4	2012	We show that exposure of human airway epithelial cells to subtoxic doses of cadmium in vitro promotes a characteristic inflammatory cytokine response consisting of IL-8, but not IL-1beta or tumor necrosis factor-alpha.	Cadmium	76-83	interleukin 1 beta	Homo sapiens	178-217
21994322-8	2012	Our study also demonstrates the role of reactive oxygen species in HCV-induced IL-1beta secretion.	Reactive Oxygen Species	40-63	interleukin 1 beta	Homo sapiens	79-87
21902467-8	2012	HNC-based constructs exhibited a more efficient recovery upon IL-1beta withdrawal, resulting in a higher accumulation of GAG (up to 2.6-fold) compared to the corresponding HAC-based tissues.	Glycosaminoglycans	121-124	interleukin 1 beta	Homo sapiens	62-70
22173128-6	2012	Treatment of HMC-cells with the c-Kit inhibitor STI571 blocked the IL-1beta-induced activation of Erk1/2 and JNK1/2 but not p38 and NFkappaB.	Imatinib Mesylate	48-54	interleukin 1 beta	Homo sapiens	67-75
22178606-6	2012	HG-induced expression of TNF-alpha, IL-6, IL-1beta, IL-4, and VEGF was blocked by ROS scavenger and inhibitors specific for NF-kappaB and STAT 3, respectively.	Reactive Oxygen Species	82-85	interleukin 1 beta	Homo sapiens	42-50
22044919-0	2012	Resveratrol inhibits interleukin 1beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappaB activity.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	21-38
22044919-3	2012	We found that when chondrocytes were stimulated with interleukin 1beta (IL-1beta), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol.	Nitric Oxide	136-148	interleukin 1 beta	Homo sapiens	53-70
22044919-3	2012	We found that when chondrocytes were stimulated with interleukin 1beta (IL-1beta), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol.	Nitric Oxide	136-148	interleukin 1 beta	Homo sapiens	72-80
22044919-3	2012	We found that when chondrocytes were stimulated with interleukin 1beta (IL-1beta), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol.	Resveratrol	227-238	interleukin 1 beta	Homo sapiens	53-70
22044919-3	2012	We found that when chondrocytes were stimulated with interleukin 1beta (IL-1beta), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol.	Resveratrol	227-238	interleukin 1 beta	Homo sapiens	72-80
21399480-5	2012	Risk may be enhanced by neuroleptics (up-regulate TF), haloperidol (up-regulates IL1B and PION), olanzapine (down-regulates THRA and PRNP, up-regulates IL1A), and chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).	Haloperidol	55-66	interleukin 1 beta	Homo sapiens	81-85
22787594-1	2012	In particular, glia may facilitate the establishment of epilepsy by impaired removal of glutamate from synapses or by releasing inflammatory cytokines and excitatory neurotransmitters, such as interleukin-1beta or, respectively, glutamate, aspartate and D-serine.	Aspartic Acid	240-249	interleukin 1 beta	Homo sapiens	193-210
22787594-1	2012	In particular, glia may facilitate the establishment of epilepsy by impaired removal of glutamate from synapses or by releasing inflammatory cytokines and excitatory neurotransmitters, such as interleukin-1beta or, respectively, glutamate, aspartate and D-serine.	D-serine	254-262	interleukin 1 beta	Homo sapiens	193-210
21399480-5	2012	Risk may be enhanced by neuroleptics (up-regulate TF), haloperidol (up-regulates IL1B and PION), olanzapine (down-regulates THRA and PRNP, up-regulates IL1A), and chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).	Olanzapine	97-107	interleukin 1 beta	Homo sapiens	243-247
21399480-4	2012	Risk may be attenuated by antipsychotics and lithium (down-regulate TNF), atypical antipsychotics (down-regulate TF), risperidone (down-regulates IL1B), olanzapine (up-regulates TFAM, down-regulates PRNP), fluoxetine (up-regulates CLU, SORCS1, NEDD9, GRN, and ECE1), and lithium coadministered with antipsychotics (down-regulates IL1B).	Risperidone	118-129	interleukin 1 beta	Homo sapiens	146-150
21940790-8	2012	Stimulation of endogenous PGE2 secretion by IL-1beta was associated with amelioration of their myofibroblast differentiation in vitro, whereas its inhibition by indomethacin augmented alpha-SMA expression.	Dinoprostone	26-30	interleukin 1 beta	Homo sapiens	44-52
23383400-4	2012	At baseline, PBMCs of four sALS patients (Group 1) showed significantly increased expression of TLR2 and CD14; ALOX5, PTGS2 and MMP1; IL1alpha, IL1beta, IL6, IL36G, IL8 and TNF; CCL3, CCL20, CXCL2, CXCL3 and CXCL5.	sals	27-31	interleukin 1 beta	Homo sapiens	144-151
22086137-9	2012	Our results show that high glucose concentrations (12 mM and particularly 24 mM) alter the biomineralization process in osteoblastic cells and provoke the following: i) a rise in mineralization, ii) an increase in the mRNA expression of RANKL and a decrease of OPG, iii) an increase in the mRNA expression of osteocalcin, bone sialoprotein and the transcription factor Runx2, iv) a diminished quality of the mineral, and v) an increase in the expression of IL1beta, IL6, IL8, MCP-1 and IL10 mRNAs.	Glucose	27-34	interleukin 1 beta	Homo sapiens	457-464
22056360-5	2012	We further showed that EGCG reduced production of interferon-gamma, IL-17, IL-6, IL-1beta, and tumor necrosis factor-alpha; decreased types 1 and 17 helper T cells (Th1 and Th17, respectively); and increased regulatory T-cell populations in lymph nodes, the spleen, and the central nervous system.	epigallocatechin gallate	23-27	interleukin 1 beta	Homo sapiens	81-89
22993937-3	2012	The treatment with azithromycin, in addition to the high eradication rates, was also evident of its effect on the cytokine levels in the patients, that was characteristic of a significant increase of the IFN-gamma level and a decrease of the IL-1beta and IL-6 levels in the blood.	Azithromycin	19-31	interleukin 1 beta	Homo sapiens	242-250
21898357-2	2012	Although this prostanoid and the enzymes responsible for its synthesis are up-regulated by interleukin-1beta (IL-1beta) in human chondrocytes in vitro, the role of PGD2 in arthritis remains unclear.	Prostaglandins	14-24	interleukin 1 beta	Homo sapiens	91-108
21898357-2	2012	Although this prostanoid and the enzymes responsible for its synthesis are up-regulated by interleukin-1beta (IL-1beta) in human chondrocytes in vitro, the role of PGD2 in arthritis remains unclear.	Prostaglandins	14-24	interleukin 1 beta	Homo sapiens	110-118
22275254-6	2012	Furthermore, IL-1beta/IL-1ra ratio was significantly higher in the CSF of active MS subjects, and correlated with intracortical facilitation, an accredited TMS measure of glutamate transmission.	Glutamic Acid	171-180	interleukin 1 beta	Homo sapiens	13-21
21861984-8	2012	IL-1beta promotes HMGB1 production in human gingival epithelial cells in a nitric oxide-dependent manner.	Nitric Oxide	75-87	interleukin 1 beta	Homo sapiens	0-8
22799333-4	2012	HMGB1 was also found significantly enhanced the activity of ATP to induce IL-1beta and IL-18 by the induction of increased expression of pro-IL-1beta and pro-IL-18.	Adenosine Triphosphate	60-63	interleukin 1 beta	Homo sapiens	74-82
22799333-4	2012	HMGB1 was also found significantly enhanced the activity of ATP to induce IL-1beta and IL-18 by the induction of increased expression of pro-IL-1beta and pro-IL-18.	Adenosine Triphosphate	60-63	interleukin 1 beta	Homo sapiens	137-149
23113413-4	2012	Concentrations of IL-1beta, IL-6 and IL-8 related to creatinine levels (pg/micromol) were determined in urine samples in all.	Creatinine	53-63	interleukin 1 beta	Homo sapiens	18-26
21669040-5	2012	Exenatide treatment improved islet function, significantly reduced content of inflammation-related  molecules (tissue factor, IFN-gamma, IL-17, IL-1beta, and IL-2) and caspase 3 activation, whereas increased phosphorylation of ERK1/2, STAT3, and Akt in vitro.	Exenatide	0-9	interleukin 1 beta	Homo sapiens	144-152
22531483-0	2012	Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1beta production from monocytes in humans.	Hexoses	7-13	interleukin 1 beta	Homo sapiens	94-102
22149896-6	2012	IL-1beta (5 ng/ml)-induced COX-2/PGE(2) levels are downregulated by stretch in RA FLSs only.	Dinoprostone	33-39	interleukin 1 beta	Homo sapiens	0-8
22187328-13	2012	Compositional analysis of labeled disaccharides showed changes in the amount of 6-O-sulfated glucosamine residues after treatment with TNF-alpha, IL-1alpha and IL-1beta.	Disaccharides	34-47	interleukin 1 beta	Homo sapiens	160-168
22449139-9	2012	It was also found that NF-kappaB inhibitor, but not ERK1/2 inhibitor, attenuated EDP-dependent induction of IL-1alpha, IL-1beta, and IL-6 expression, indicating that NF-kappaB pathways are required for EDP-induced IL-1alpha, IL-1beta, and IL-6 gene expression in human LF cells.	2-ethyl-3,5-dimethylpyrazine	81-84	interleukin 1 beta	Homo sapiens	119-127
22449139-9	2012	It was also found that NF-kappaB inhibitor, but not ERK1/2 inhibitor, attenuated EDP-dependent induction of IL-1alpha, IL-1beta, and IL-6 expression, indicating that NF-kappaB pathways are required for EDP-induced IL-1alpha, IL-1beta, and IL-6 gene expression in human LF cells.	2-ethyl-3,5-dimethylpyrazine	81-84	interleukin 1 beta	Homo sapiens	225-233
23025052-4	2012	Diverse effects of cycloferon on biochemical and cellular cascades (including induction of alpha- and beta-interferon, inhibition ofproapoptotic factors such as tumor necrosis factor and interleukin 1-beta) suggest that it also takes active part in the regulation of apoptosis, one of the most important processes of cell activity that opens up new prospects for the therapeutic use of cycloferon.	10-carboxymethyl-9-acridanone	19-29	interleukin 1 beta	Homo sapiens	187-205
22186417-9	2012	Cotreatment with LPS and sodium propionate decreased LPS-induced expression of inflammatory genes including IL-6, IL-8, cyclooxygenase-2, IL-1alpha, intercellular adhesion molecule-1, and platelet endothelial cell adhesion molecule-1 but not IL-1beta or lymphocyte function-associated antigen-1.	sodium propionate	25-42	interleukin 1 beta	Homo sapiens	242-250
23885401-2	2012	The cholestatic effect of cytokines (e.g. IL-1beta, IL-6) is believed to result from the repression of genes that normally mediated the hepatic uptake, metabolism, and biliary excretion of bile salts and bilirubin.	Bile Acids and Salts	189-199	interleukin 1 beta	Homo sapiens	42-50
23885401-2	2012	The cholestatic effect of cytokines (e.g. IL-1beta, IL-6) is believed to result from the repression of genes that normally mediated the hepatic uptake, metabolism, and biliary excretion of bile salts and bilirubin.	Bilirubin	204-213	interleukin 1 beta	Homo sapiens	42-50
23885401-9	2012	A significant positive correlation was found between of IL-1beta in breast milk and total serum bilirubin levels (r = 0.494, P &lt; 0.001).	Bilirubin	96-105	interleukin 1 beta	Homo sapiens	56-64
22067128-7	2012	There were increased levels of IL-1beta, IL-6, MMP-1, MMP-3, and MMP-9 and decreased levels of TIMP-1 and TIMP-2 in the tears of PG-treated patients.	Prostaglandins	129-131	interleukin 1 beta	Homo sapiens	31-39
22187328-13	2012	Compositional analysis of labeled disaccharides showed changes in the amount of 6-O-sulfated glucosamine residues after treatment with TNF-alpha, IL-1alpha and IL-1beta.	6-o	80-83	interleukin 1 beta	Homo sapiens	160-168
22187328-13	2012	Compositional analysis of labeled disaccharides showed changes in the amount of 6-O-sulfated glucosamine residues after treatment with TNF-alpha, IL-1alpha and IL-1beta.	Glucosamine	93-104	interleukin 1 beta	Homo sapiens	160-168
22179678-0	2012	Polyoxypregnane glycoside from Dregea volubilis extract inhibits IL-1beta-induced expression of matrix metalloproteinase via activation of NF-kappaB in human chondrocytes.	12-0-benzoyl-8,11-ditigloyl-3,8,11,12-pentahydroxy-pregn-14-ol, 20-one 3-0-methyl-allopyranosyl(1-4)-thevetopyranoside	0-25	interleukin 1 beta	Homo sapiens	65-73
22489138-4	2012	Our current study demonstrated that BDMC33 inhibits the secretion of major pro-inflammatory mediators in stimulated macrophages, and includes NO, TNF-alpha and IL-1beta through interference in both nuclear factor kappaB (NF-kappaB) and mitogen activator protein kinase (MAPK) signaling cascade in IFN-gamma/LPS-stimulated macrophages.	2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone	36-42	interleukin 1 beta	Homo sapiens	160-168
23304632-7	2012	Immunohistochemistry and real-time PCR revealed that the expression of globotriaosylceramide (Gb3), the receptor for Stx2, and Gb3 synthase (GalT6) in HASTs was increased by interleukin-1beta (IL-1beta).	globotriaosylceramide	71-92	interleukin 1 beta	Homo sapiens	174-191
23304632-7	2012	Immunohistochemistry and real-time PCR revealed that the expression of globotriaosylceramide (Gb3), the receptor for Stx2, and Gb3 synthase (GalT6) in HASTs was increased by interleukin-1beta (IL-1beta).	globotriaosylceramide	71-92	interleukin 1 beta	Homo sapiens	193-201
22132000-0	2012	The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population.	Aspirin	64-71	interleukin 1 beta	Homo sapiens	4-8
23251812-6	2012	Compared to the THP-1 macrophages without palmitic acid, the level of TLR4 mRNA protein and NF-kappaB p65 phosphorylation and the expression of TNF-alpha and IL-1beta increased after treatment by palmitic acid in a dose-dependent fashion (P &lt; 0.05).	Palmitic Acid	196-209	interleukin 1 beta	Homo sapiens	158-166
22132000-4	2012	We performed a genetic association study between IL8-251 (rs4073) and IL1B-511 (rs16944) polymorphisms in AERD, aspirin-tolerant asthma (ATA), and healthy control subjects.	Aspirin	112-119	interleukin 1 beta	Homo sapiens	70-74
22013105-8	2012	After a single injection of exenatide, there was a reduction by 20 +- 7% in free fatty acids, 19 +- 7% in reactive oxygen species generation, 39 +- 11% in nuclear factor-kappaB binding, 18 +- 9% in TNFalpha expression, 26 +- 7% in IL-1beta expression, 18 +- 7% in JNK-1 expression, 24 +- 12% in TLR-4 expression, and 23 +- 11% in SOCS-3 expression (P &lt; 0.05 for all).	Exenatide	28-37	interleukin 1 beta	Homo sapiens	231-239
22430528-8	2012	XG significantly attenuated Abeta-stimulated release of inflammatory factors such as tumor necrosis factor-alpha, interleukin-1beta, and prostaglandin E2.	xg	0-2	interleukin 1 beta	Homo sapiens	114-131
22247602-12	2012	In conclusions, butyrate enhances interleukin-1beta production by activating caspase-1, via reactive oxygen species, the phosphorylation of MAPK, and G protein mediated pathways in lipopolysaccharide stimulated THP-1 cells.	Butyrates	16-24	interleukin 1 beta	Homo sapiens	34-51
22247602-12	2012	In conclusions, butyrate enhances interleukin-1beta production by activating caspase-1, via reactive oxygen species, the phosphorylation of MAPK, and G protein mediated pathways in lipopolysaccharide stimulated THP-1 cells.	Reactive Oxygen Species	92-115	interleukin 1 beta	Homo sapiens	34-51
22247602-3	2012	We investigated the effect of butyrate on interleukin-1beta production in macrophage and elucidated its underlying mechanism.	Butyrates	30-38	interleukin 1 beta	Homo sapiens	42-59
22247602-5	2012	Butyrate with lipopolysaccharide increased interleukin-1beta production more than lipopolysaccharide alone.	Butyrates	0-8	interleukin 1 beta	Homo sapiens	43-60
22247602-7	2012	As for the phosphorylation pathway, PD98059 (ERK1/2 inhibitor), SB203580 (p38 MAPK inhibitor), SP600125 (JNK1/2 inhibitor) decreased caspase-1 activity and interleukin-1beta production to approximately 50% of the controls.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	36-43	interleukin 1 beta	Homo sapiens	156-173
22016358-4	2012	Med and Med + CoQ diets produced a lower fasting calreticulin, IL-1b, and JNK-1 gene expression; a lower postprandial p65, IKK-b, MMP-9, IL-1b, JNK-1, sXBP-1, and BiP/Grp78 gene expression; and a higher postprandial IkB-a gene expression compared with the SFA diet.	coenzyme Q10	14-17	interleukin 1 beta	Homo sapiens	63-68
22247602-7	2012	As for the phosphorylation pathway, PD98059 (ERK1/2 inhibitor), SB203580 (p38 MAPK inhibitor), SP600125 (JNK1/2 inhibitor) decreased caspase-1 activity and interleukin-1beta production to approximately 50% of the controls.	SB 203580	64-72	interleukin 1 beta	Homo sapiens	156-173
22016358-4	2012	Med and Med + CoQ diets produced a lower fasting calreticulin, IL-1b, and JNK-1 gene expression; a lower postprandial p65, IKK-b, MMP-9, IL-1b, JNK-1, sXBP-1, and BiP/Grp78 gene expression; and a higher postprandial IkB-a gene expression compared with the SFA diet.	coenzyme Q10	14-17	interleukin 1 beta	Homo sapiens	137-142
22878602-7	2012	TEM demonstrated that IL-1beta severely alters the structure of chondrocytes; after co-incubation with VA441 or celecoxib, the cells recovered their ultrastructure.	2-methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(2-n-propyloxyethyl)-1H-pyrrole	103-108	interleukin 1 beta	Homo sapiens	22-30
22878602-0	2012	In vitro effects of VA441, a new selective cyclooxygenase-2 inhibitor, on human osteoarthritic chondrocytes exposed to IL-1beta.	2-methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(2-n-propyloxyethyl)-1H-pyrrole	20-25	interleukin 1 beta	Homo sapiens	119-127
22102722-6	2012	Similarly, the P2Y(6)-specific antagonist completely inhibited the MSU-induced production of IL-1beta by THP-1 cells, a human monocytic cell line.	Uric Acid	67-70	interleukin 1 beta	Homo sapiens	93-101
22878602-7	2012	TEM demonstrated that IL-1beta severely alters the structure of chondrocytes; after co-incubation with VA441 or celecoxib, the cells recovered their ultrastructure.	Celecoxib	112-121	interleukin 1 beta	Homo sapiens	22-30
22878602-1	2012	The aim of this in vitro study was to examine the possible effect of [2-methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(2-n-propyloxyethyl)]-1H-pyrrole (VA441), a new selective cyclooxygenase (COX)-2 inhibitor, on human osteoarthritic (OA) chondrocyte cultivated in the presence or absence of interleukin-1beta (IL-1beta).	Pyrroles	140-150	interleukin 1 beta	Homo sapiens	292-309
22878602-1	2012	The aim of this in vitro study was to examine the possible effect of [2-methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(2-n-propyloxyethyl)]-1H-pyrrole (VA441), a new selective cyclooxygenase (COX)-2 inhibitor, on human osteoarthritic (OA) chondrocyte cultivated in the presence or absence of interleukin-1beta (IL-1beta).	Pyrroles	140-150	interleukin 1 beta	Homo sapiens	311-319
22157665-5	2012	The CGCG compared to the PGCG showed significantly increased expression of TNF-alpha and IL-6 and decreased expression of IL-1beta by the spindle-shaped cells and increased expression of IL-1beta by the MGCs.	cgcg	4-8	interleukin 1 beta	Homo sapiens	122-130
22878602-4	2012	The presence of IL-1beta led to a significant increase in PGE(2), MMP-3, and NO production, as well as a significant increase in gene expression of COX-2 and iNOS.	Prostaglandins E	58-61	interleukin 1 beta	Homo sapiens	16-24
22878602-6	2012	VA441 and celecoxib significantly suppressed IL-1beta-stimulated MMP-3 and NO and iNOS gene expression in a dose-dependent manner, while indomethacin did not show any significant effect on MMP-3 and NO production or on iNOS gene expression.	2-methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(2-n-propyloxyethyl)-1H-pyrrole	0-5	interleukin 1 beta	Homo sapiens	45-53
22878602-6	2012	VA441 and celecoxib significantly suppressed IL-1beta-stimulated MMP-3 and NO and iNOS gene expression in a dose-dependent manner, while indomethacin did not show any significant effect on MMP-3 and NO production or on iNOS gene expression.	Celecoxib	10-19	interleukin 1 beta	Homo sapiens	45-53
22157665-5	2012	The CGCG compared to the PGCG showed significantly increased expression of TNF-alpha and IL-6 and decreased expression of IL-1beta by the spindle-shaped cells and increased expression of IL-1beta by the MGCs.	cgcg	4-8	interleukin 1 beta	Homo sapiens	187-195
22157665-5	2012	The CGCG compared to the PGCG showed significantly increased expression of TNF-alpha and IL-6 and decreased expression of IL-1beta by the spindle-shaped cells and increased expression of IL-1beta by the MGCs.	pgcg	25-29	interleukin 1 beta	Homo sapiens	122-130
22719178-6	2012	Much data showed that macrolides reduced viral titers of RV ICAM-1, which is the receptor for RV, and RV infection-induced cytokines including IL-1beta, IL-6, IL-8, and TNF-alpha.	Macrolides	22-32	interleukin 1 beta	Homo sapiens	143-151
22157665-5	2012	The CGCG compared to the PGCG showed significantly increased expression of TNF-alpha and IL-6 and decreased expression of IL-1beta by the spindle-shaped cells and increased expression of IL-1beta by the MGCs.	pgcg	25-29	interleukin 1 beta	Homo sapiens	187-195
22157665-7	2012	CONCLUSIONS: The proinflammatory cytokines TNF-alpha, IL-6 and IL-1beta seem to be involved in the growth process of PGCG and CGCG of the jaws.	pgcg	117-121	interleukin 1 beta	Homo sapiens	63-71
22157665-7	2012	CONCLUSIONS: The proinflammatory cytokines TNF-alpha, IL-6 and IL-1beta seem to be involved in the growth process of PGCG and CGCG of the jaws.	cgcg	126-130	interleukin 1 beta	Homo sapiens	63-71
23284753-6	2012	Neutralisation of IL-1beta and IL-23, but not IL-6, suppressed the IL-17A-enhancing effect of dmLT.	dmlt	94-98	interleukin 1 beta	Homo sapiens	18-26
22629855-2	2012	All of myelopeptides under examination in case of one-way introduction in cultures with zymosan demonstrated a decrease in zymosan-stimulated (1500 mkg/ml) production of IL-1beta, and activation of spontaneous production of this cytokine by whole blood cells.	Zymosan	88-95	interleukin 1 beta	Homo sapiens	170-178
22629855-2	2012	All of myelopeptides under examination in case of one-way introduction in cultures with zymosan demonstrated a decrease in zymosan-stimulated (1500 mkg/ml) production of IL-1beta, and activation of spontaneous production of this cytokine by whole blood cells.	Zymosan	123-130	interleukin 1 beta	Homo sapiens	170-178
23240010-6	2012	MAPK"s role in IL-1beta-induced COX-2 expression was assessed by treating cells with ERK (PD98059), JNK (SP600125) and p38 MAPK (SB203580) inhibitors (0.1-10 microM) prior to IL-1beta exposure.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	90-97	interleukin 1 beta	Homo sapiens	15-23
23240010-6	2012	MAPK"s role in IL-1beta-induced COX-2 expression was assessed by treating cells with ERK (PD98059), JNK (SP600125) and p38 MAPK (SB203580) inhibitors (0.1-10 microM) prior to IL-1beta exposure.	pyrazolanthrone	105-113	interleukin 1 beta	Homo sapiens	15-23
23240010-6	2012	MAPK"s role in IL-1beta-induced COX-2 expression was assessed by treating cells with ERK (PD98059), JNK (SP600125) and p38 MAPK (SB203580) inhibitors (0.1-10 microM) prior to IL-1beta exposure.	SB 203580	129-137	interleukin 1 beta	Homo sapiens	15-23
23226286-8	2012	Finally, it is shown that sea bass and avian IL-1beta are specifically cleaved by caspase-1 at different but phylogenetically conserved aspartates, distinct from the cleavage site of mammalian IL-1beta.	Aspartic Acid	136-146	interleukin 1 beta	Homo sapiens	45-53
23209664-3	2012	We used reporter constructs to demonstrate that interleukin 1beta (IL-1beta) inhibits progesterone driven PRE activation via p65 activation and that IL-1beta reduced progesterone driven gene expression (FKBP5).	Progesterone	86-98	interleukin 1 beta	Homo sapiens	48-65
23209664-3	2012	We used reporter constructs to demonstrate that interleukin 1beta (IL-1beta) inhibits progesterone driven PRE activation via p65 activation and that IL-1beta reduced progesterone driven gene expression (FKBP5).	Progesterone	86-98	interleukin 1 beta	Homo sapiens	67-75
23209664-6	2012	However, we found that the ability of MPA to repress IL-1beta-driven COX-2 expression was not enhanced by overexpression of either PRB or PRA and that although the combined PR and GR antagonist Ru486 blocked the effects of progesterone and MPA, the specific PR antagonist, Org31710, did not, suggesting that progesterone and MPA act via GR and not PR.	Mifepristone	194-199	interleukin 1 beta	Homo sapiens	53-61
23110185-8	2012	Treatment of neutrophils from healthy subjects with TNFalpha, IL-1beta, or IL-8 enhanced free radicals generation and NETs formation, which was mediated through the activation of NADPH oxidase and MPO.	Free Radicals	89-102	interleukin 1 beta	Homo sapiens	62-70
23166834-6	2012	AAP also induced NFkB p65 activation by phosphorylation and its translocation to the nucleus, where NFkB p65 increased IL-1beta production.	Acetaminophen	0-3	interleukin 1 beta	Homo sapiens	119-127
22952811-7	2012	In vitro Pb-exposure also induced significantly increase of microglia activation, up-regulate the release of cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in microglia culture alone as well as neuronal injury in the co-culture with hippocampal neurons.	Lead	9-11	interleukin 1 beta	Homo sapiens	170-187
22916253-11	2012	Moreover, we found that both LPS and CpG oligodeoxynucleotides (ODN) induced robust pro-inflammatory responses in thrombocytes, as characterized by more than 100 fold increase in interleukin (IL)-1beta, IL-6 and IL-8 transcripts, while only LPS enhanced nitric oxide production and phagocytic capabilities.	CPG-oligonucleotide	37-62	interleukin 1 beta	Homo sapiens	179-201
22952811-7	2012	In vitro Pb-exposure also induced significantly increase of microglia activation, up-regulate the release of cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in microglia culture alone as well as neuronal injury in the co-culture with hippocampal neurons.	Lead	9-11	interleukin 1 beta	Homo sapiens	189-197
22952811-9	2012	Our results showed that Pb can cause microglia activation, which can up-regulate the level of IL-1beta, TNF-alpha and iNOS, these proinflammatory factors may cause hippocampal neuronal injury as well as LTP deficits.	Lead	24-26	interleukin 1 beta	Homo sapiens	94-102
22844504-6	2012	In both models MC-12: reversed dose-dependently colonic inflammation; inhibited by up to 47% myeloperoxidase activity; had a minimal effect on cytoplasmic phospholipase A(2); reduced significantly the induced levels of TNF-alpha, IFN-gamma, IL-1beta, IL-6 and IL-10, returning them to baseline.	mc-12	15-20	interleukin 1 beta	Homo sapiens	241-249
22844468-2	2012	Recently, AbM extract was shown to induce the production of the pro-inflammatory cytokine, interleukin-1beta (IL-1beta), in human monocytes.	abm	10-13	interleukin 1 beta	Homo sapiens	91-108
22479453-0	2012	Methamphetamine increases LPS-mediated expression of IL-8, TNF-alpha and IL-1beta in human macrophages through common signaling pathways.	Methamphetamine	0-15	interleukin 1 beta	Homo sapiens	73-81
22844468-2	2012	Recently, AbM extract was shown to induce the production of the pro-inflammatory cytokine, interleukin-1beta (IL-1beta), in human monocytes.	abm	10-13	interleukin 1 beta	Homo sapiens	110-118
22844468-4	2012	The purpose of this study is to investigate the effect of AbM water extracts on the regulation of IL-1beta production and activation of the NLRP3 inflammasome in human THP-1 macrophages.	Water	62-67	interleukin 1 beta	Homo sapiens	98-106
22844468-9	2012	In addition, caspase-1 was activated and involved in proteolytic cleavage and secretion of IL-1beta in AbM-treated macrophages.	abm	103-106	interleukin 1 beta	Homo sapiens	91-99
22844468-10	2012	AbM-mediated IL-1beta secretion also decreased in cells treated with cathepsin B inhibitor, suggesting that AbM can induce the release of cathepsin B.	abm	0-3	interleukin 1 beta	Homo sapiens	13-21
22860122-0	2012	Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1beta-stimulated fibroblast-like synoviocytes.	aciculatin	0-10	interleukin 1 beta	Homo sapiens	78-95
22860122-5	2012	Whether aciculatin inhibited IL-1beta-stimulated G-CSF expression, and if so, how, were evaluated using western blot assay, an electrophoretic mobility shift assay, and a reporter gene assay.	aciculatin	8-18	interleukin 1 beta	Homo sapiens	29-37
22860122-7	2012	Aciculatin markedly inhibited G-CSF expression induced by IL-1beta (10 ng/mL) in a concentration-dependent manner (1-10 microM).	aciculatin	0-10	interleukin 1 beta	Homo sapiens	58-66
22860122-8	2012	In clarifying the mechanisms involved, aciculatin was found to inhibit the IL-1beta-induced activation of the IkappaB kinase (IKK)/IkappaB/nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) pathways by suppressing the DNA binding activity of the transcription factors NF-kappaB and activator protein (AP)-1.	aciculatin	39-49	interleukin 1 beta	Homo sapiens	75-83
22860122-10	2012	Our results show that aciculatin inhibits IL-1beta-stimulated G-CSF expression and the subsequent neutrophil differentiation, suggesting that it might have therapeutic potential for inflammatory arthritis.	aciculatin	22-32	interleukin 1 beta	Homo sapiens	42-50
22815767-5	2012	Treatment of the human cell line A431 with interleukin-1beta (IL-1beta) increased mPGES-1 expression, PGE(2) production and induced EGFR phosphorylation, and vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expression.	Prostaglandins E	83-86	interleukin 1 beta	Homo sapiens	43-60
22815767-5	2012	Treatment of the human cell line A431 with interleukin-1beta (IL-1beta) increased mPGES-1 expression, PGE(2) production and induced EGFR phosphorylation, and vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expression.	Prostaglandins E	83-86	interleukin 1 beta	Homo sapiens	62-70
22815786-5	2012	METHODOLOGY/ PRINCIPAL FINDINGS: The effect of atorvastatin on secretion levels and subcellular distribution of GRO-alpha, IL-8 and MCP-1 in HUVECs activated by interleukin (IL)-1beta were evaluated by ELISA, confocal microscopy and immunoelectron microscopy.	Atorvastatin	47-59	interleukin 1 beta	Homo sapiens	161-183
22983102-1	2012	BACKGROUND AND OBJECTIVES: In this study we assesed the effect of a small dose of ketamine on the production of TNFalpha, IL-1beta and IL-6 and the postoperative pain in patients undergoing laparoscopic cholecystectomy.	Ketamine	82-90	interleukin 1 beta	Homo sapiens	122-130
22384041-8	2012	Moreover, we found that the MAP-kinase inhibitor SB203580 blocked activation of cytoplasmic tail-deficient ADAM17 and of the T735A mutant by IL-1beta or by anisomycin, providing further support for a model in which the activation mechanism of ADAM17 does not rely on its cytoplasmic domain or phosphorylation of T735.	SB 203580	49-57	interleukin 1 beta	Homo sapiens	141-149
22393394-7	2012	CONCLUSION/SIGNIFICANCE: Our results identify a mechanism mediated by Reactive Oxygen Species (ROS) production and potassium efflux as the two danger signals that link JEV infection to caspase-1 activation resulting in subsequent IL-1beta and IL-18 maturation.	Reactive Oxygen Species	70-93	interleukin 1 beta	Homo sapiens	230-238
22393394-7	2012	CONCLUSION/SIGNIFICANCE: Our results identify a mechanism mediated by Reactive Oxygen Species (ROS) production and potassium efflux as the two danger signals that link JEV infection to caspase-1 activation resulting in subsequent IL-1beta and IL-18 maturation.	Reactive Oxygen Species	95-98	interleukin 1 beta	Homo sapiens	230-238
22359588-0	2012	Anti-arthritic effects of magnolol in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in a rat arthritis model.	magnolol	26-34	interleukin 1 beta	Homo sapiens	44-61
22983102-10	2012	CONCLUSIONS: The addition of a small-dose of ketamine in patiens undergoing laparoscopic cholecystectomy resulted in attenuation of secretion of TNFalpha, IL-1beta, IL-6 and reduction of postoperative pain.	Ketamine	45-53	interleukin 1 beta	Homo sapiens	155-163
21912093-8	2012	RESULTS: Analytes sensitive to dithiothreitol (DTT) that had increased recovery in the 2-step sputum process were IL-1beta, 4, 5, 10, 13, IFN-gamma, TNFRI, GM-CSF, CCL2, 3, 4, 5, 13 and 17.	Dithiothreitol	31-45	interleukin 1 beta	Homo sapiens	114-122
21912093-8	2012	RESULTS: Analytes sensitive to dithiothreitol (DTT) that had increased recovery in the 2-step sputum process were IL-1beta, 4, 5, 10, 13, IFN-gamma, TNFRI, GM-CSF, CCL2, 3, 4, 5, 13 and 17.	Dithiothreitol	47-50	interleukin 1 beta	Homo sapiens	114-122
21971413-0	2011	Rottlerin enhances IL-1beta-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells.	rottlerin	0-9	interleukin 1 beta	Homo sapiens	19-27
22759998-4	2012	Upregulation of IL-6, IL-1beta, CYP1B1, CXCL1, CCL18 and KAP 4-2 gene expression and downregulation of psorasin mRNA and protein expression were identified in samples treated topically with dexpanthenol.	dexpanthenol	190-202	interleukin 1 beta	Homo sapiens	22-30
22640617-3	2012	IL1beta and TNFalpha are released from glia in response to extracellular ATP.	Adenosine Triphosphate	73-76	interleukin 1 beta	Homo sapiens	0-7
21971413-9	2011	Taken together, our results suggest that rottlerin causes IL-1beta-induced COX-2 upregulation through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells.	rottlerin	41-50	interleukin 1 beta	Homo sapiens	58-66
21971413-2	2011	In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231 human breast cancer cell line.	rottlerin	95-104	interleukin 1 beta	Homo sapiens	108-124
21971413-2	2011	In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231 human breast cancer cell line.	rottlerin	95-104	interleukin 1 beta	Homo sapiens	126-134
21971413-3	2011	Treatment with rottlerin enhanced IL-1beta-induced COX-2 expression at both the protein and mRNA levels.	rottlerin	15-24	interleukin 1 beta	Homo sapiens	34-42
21971413-6	2011	Also, a pharmacological inhibitor of p38 MAPK (SB 203580) and transient transfection with inactive p38 MAPK inhibited rottlerin and IL-1beta-induced COX-2 upregulation.	SB 203580	47-56	interleukin 1 beta	Homo sapiens	132-140
22047207-2	2011	We demonstrate that the dispersal of as-prepared (AP), purified (PD), and carboxylated (COOH) MWCNTs by bovine serum albumin (BSA) and dipalmitoylphosphatidylcholine (DPPC) influences TGF-beta1, PDGF-AA, and IL-1beta production in vitro and in vivo.	Carbonic Acid	88-92	interleukin 1 beta	Homo sapiens	208-216
22193447-11	2011	Furthermore, the induced IL-1beta and TNF-alpha transcription was also inhibited by MG-132 treatment, which may be due to the inhibition of NF-kappaBp65 nuclear translocation by MG-132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	84-90	interleukin 1 beta	Homo sapiens	25-33
22111911-3	2011	Here we demonstrate that amino-functionalized polystyrene nanoparticles (PS-NH(2)) of ~100 nm in diameter, but not carboxyl- or nonfunctionalized particles, trigger NLRP3 inflammasome activation and subsequent release of proinflammatory interleukin 1beta (IL-1beta) by human macrophages.	Polystyrenes	46-57	interleukin 1 beta	Homo sapiens	237-254
22111911-3	2011	Here we demonstrate that amino-functionalized polystyrene nanoparticles (PS-NH(2)) of ~100 nm in diameter, but not carboxyl- or nonfunctionalized particles, trigger NLRP3 inflammasome activation and subsequent release of proinflammatory interleukin 1beta (IL-1beta) by human macrophages.	Polystyrenes	46-57	interleukin 1 beta	Homo sapiens	256-264
22111911-10	2011	The PS-NH(2)-mediated proinflammatory macrophage activation could be antagonized by the radical scavenger N-acetyl-L-cysteine, which prevented mitochondrial damage, caspase-1 activation, and the subsequent release of IL-1beta.	ps-nh(2)	4-12	interleukin 1 beta	Homo sapiens	217-225
22111911-10	2011	The PS-NH(2)-mediated proinflammatory macrophage activation could be antagonized by the radical scavenger N-acetyl-L-cysteine, which prevented mitochondrial damage, caspase-1 activation, and the subsequent release of IL-1beta.	Acetylcysteine	106-125	interleukin 1 beta	Homo sapiens	217-225
22193447-11	2011	Furthermore, the induced IL-1beta and TNF-alpha transcription was also inhibited by MG-132 treatment, which may be due to the inhibition of NF-kappaBp65 nuclear translocation by MG-132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	178-184	interleukin 1 beta	Homo sapiens	25-33
21930886-6	2011	An array screening assay revealed that rifampin stimulated the production of IL-1beta and gamma interferon-induced protein-10 (IP-10) in untreated cells and increased the secretion of RANTES in cytokine-treated cells.	Rifampin	39-47	interleukin 1 beta	Homo sapiens	77-85
25386288-6	2011	In addition, ellagic acid promoted G1 cell cycle arrest, increased levels of apoptosis and decreased synthesis of IL-1beta and IL-8 in melanoma cells.	Ellagic Acid	13-25	interleukin 1 beta	Homo sapiens	114-122
23091851-8	2012	The CHD and MS patients who carried the Pro allele showed a significant metformin-induced reduction in weight, waist circumference, body mass index, and concentrations of TC, C-peptide, and cytokines, such IL-1beta, IL-6, IL-8, and TNF-alpha.	Metformin	72-81	interleukin 1 beta	Homo sapiens	206-214
22005258-7	2011	In addition, CKS decreased UVA-induced expression of the inflammatory cytokines IL-1beta and IL-6.	uva	27-30	interleukin 1 beta	Homo sapiens	80-88
22031535-4	2011	LMW-HA-activated AFAP-110 then binds to filamentous actin (F-actin) resulting in MyD88/nuclear factor-kappaB (NF-kappaB) nuclear translocation, NF-kappaB-specific transcription, and target gene [interleukine 1beta and interleukine-8 (IL-1beta and IL-8)] expression.	lmw-ha	0-6	interleukin 1 beta	Homo sapiens	234-242
22019372-7	2011	Moreover, a cell-impermeable inhibitor, 17-N,N-dimethylaminoethylamino-17-demethoxy-geldanamycin-N-oxide, also efficiently inhibited necrosis-induced cytokine production and TNF-alpha/IL-1beta-induced increase in ARPE-19 cell permeability in vitro and endotoxin-induced development of uveitis in vivo, suggesting that HSP90 can contribute to necrosis-induced RPE inflammatory responses.	17-n	40-44	interleukin 1 beta	Homo sapiens	184-192
21274653-5	2011	The mechanisms by which calcium fructoborate exerts its beneficial anti-inflammatory effects are not entirely clear, but some of its molecular biological in vitro activities are understood: inhibition of the superoxide within the cell; inhibition of the interleukin-1beta, interleukin-6, and nitric oxide release in the culture media; and increase of the tumor necrosis factor-alpha production.	Calcium	24-31	interleukin 1 beta	Homo sapiens	254-271
21872324-4	2011	MAA beads decreased the expression of osteopontin (OPN) compared to poly(methyl methacrylate) (PMMA) and untreated cells, and increased the expression of IL-1beta, IL-6 and TNF-alpha over the 24-96 h of the experiment.	monomethylarsonic acid	0-3	interleukin 1 beta	Homo sapiens	154-162
21848814-5	2011	In this study we found that EspT induces expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) an enzyme involved in production of prostaglandin E(2) (PGE2), interleukin (Il)-8 and Il-1beta in U937 human macrophages by activating the nuclear factor kappa-B (NF-kappaB), the extracellular signal-regulated kinases 1 and 2 (Erk1/2) and c-Jun N-terminal kinase (JNK) pathways.	Dinoprostone	147-165	interleukin 1 beta	Homo sapiens	197-205
21957307-6	2011	Activation of the NLRP3 inflammasome and secretion of IL-1beta was also dependent on the release of cathepsin B and production of reactive oxygen species (ROS).	Reactive Oxygen Species	130-153	interleukin 1 beta	Homo sapiens	54-62
23487396-7	2011	LPO levels correlated directly with IL-1beta, TNF-alpha, IL-6 and IL-10.	Lipid Peroxides	0-3	interleukin 1 beta	Homo sapiens	36-44
21957307-6	2011	Activation of the NLRP3 inflammasome and secretion of IL-1beta was also dependent on the release of cathepsin B and production of reactive oxygen species (ROS).	Reactive Oxygen Species	155-158	interleukin 1 beta	Homo sapiens	54-62
21964047-5	2011	Use of prednisolone was associated with reduced levels of IL-15, IL-2, IL-4, IL-12p40, TNF-alpha, MIP-1alpha and MIP-1beta (p&lt;0.05), and a trend towards decreased levels of IL-1RA and IL-1beta was observed.	Prednisolone	7-19	interleukin 1 beta	Homo sapiens	187-195
21964048-5	2011	The treatment of EPCs with TLR3 agonist Poly I:C up-regulated the expression of cytokines IL-1beta, IL-6, IL-8, TNF-alpha, IFN-alpha, and IFN-beta, indicating that EPCs expressed functional TLR3.	Poly I	40-46	interleukin 1 beta	Homo sapiens	90-98
21964048-5	2011	The treatment of EPCs with TLR3 agonist Poly I:C up-regulated the expression of cytokines IL-1beta, IL-6, IL-8, TNF-alpha, IFN-alpha, and IFN-beta, indicating that EPCs expressed functional TLR3.	Carbon	19-20	interleukin 1 beta	Homo sapiens	90-98
21964048-7	2011	Further studies indicated that IL-1beta was involved in TLR3-induced cell proliferation inhibition, as IL-1beta inhibited cell proliferation in a dose-dependent manner, and the IL-1beta receptor type I (IL-1R1)-neutralizing antibody ameliorated Poly I:C-induced cell proliferation inhibition.	Poly I-C	245-253	interleukin 1 beta	Homo sapiens	31-39
21344389-8	2011	We found that the MEK inhibitor U0126 and the RSK inhibitor BI-D1870 both reduced IL-1B-dependent MMP-1 gene expression in SW1353 cells.	U 0126	32-37	interleukin 1 beta	Homo sapiens	82-87
21344389-8	2011	We found that the MEK inhibitor U0126 and the RSK inhibitor BI-D1870 both reduced IL-1B-dependent MMP-1 gene expression in SW1353 cells.	BI D1870	60-68	interleukin 1 beta	Homo sapiens	82-87
21920358-0	2011	Raloxifene protects cultured human chondrocytes from IL-1beta induced damage: a biochemical and morphological study.	Raloxifene Hydrochloride	0-10	interleukin 1 beta	Homo sapiens	53-61
21972293-3	2011	Exogenous PGE(2) and such diverse COX2 activators as lipopolysaccharide, IL-1beta, and IFNgamma all induce monocyte expression of COX2, blocking their differentiation into CD1a(+) DCs and inducing endogenous PGE(2), IDO1, IL-4Ralpha, NOS2, and IL-10, typical MDSC-associated suppressive factors.	Prostaglandins E	10-13	interleukin 1 beta	Homo sapiens	73-81
22359474-10	2011	The mRNA levels of iNOS, TNF-alpha, and IL-1beta were increased by MSU in human dermal fibroblasts, C2C12 myoblasts, and human fetal osteoblasts in vitro, which was attenuated by L-NIL in a dose dependent manner.	L-NIL	179-184	interleukin 1 beta	Homo sapiens	40-48
22033121-7	2011	RESULTS: After 3h of obstructive apneas, a significant increase in IL1-beta (64.9+-29.6 ng/mul) were observed with respect to the controls (7.3+-1.0 ng/mul), but no myocardial injury was present.	Tritium	15-17	interleukin 1 beta	Homo sapiens	67-75
21972293-3	2011	Exogenous PGE(2) and such diverse COX2 activators as lipopolysaccharide, IL-1beta, and IFNgamma all induce monocyte expression of COX2, blocking their differentiation into CD1a(+) DCs and inducing endogenous PGE(2), IDO1, IL-4Ralpha, NOS2, and IL-10, typical MDSC-associated suppressive factors.	Prostaglandins E	208-211	interleukin 1 beta	Homo sapiens	73-81
21910986-5	2011	Pretreatment with the HO-1 inhibitor, tin protoporphyrin (SnPP), attenuated the inhibitory activities of LA on LPS-induced inflammatory NO, PGE(2), IL-1beta, TNF-alpha, IL-6 and IL-12 production.	tin protoporphyrin IX	38-56	interleukin 1 beta	Homo sapiens	148-156
21920358-9	2011	When the cells were co-incubated with IL-1beta and raloxifene, a significant and dose-dependent increase in proteoglycans and a reduction of MMP-3 and nitric oxide (NO) were detected.	Raloxifene Hydrochloride	51-61	interleukin 1 beta	Homo sapiens	38-46
21910986-5	2011	Pretreatment with the HO-1 inhibitor, tin protoporphyrin (SnPP), attenuated the inhibitory activities of LA on LPS-induced inflammatory NO, PGE(2), IL-1beta, TNF-alpha, IL-6 and IL-12 production.	S-Nitroso-N-propionyl-D,L-penicillamine	58-62	interleukin 1 beta	Homo sapiens	148-156
21920358-9	2011	When the cells were co-incubated with IL-1beta and raloxifene, a significant and dose-dependent increase in proteoglycans and a reduction of MMP-3 and nitric oxide (NO) were detected.	Nitric Oxide	151-163	interleukin 1 beta	Homo sapiens	38-46
21940629-5	2011	The glucocorticoid-dependent induction of NLRP3 sensitizes the cells to extracellular ATP and significantly enhances the ATP-mediated release of proinflammatory molecules, including mature IL-1beta, TNF-alpha, and IL-6.	Adenosine Triphosphate	121-124	interleukin 1 beta	Homo sapiens	189-197
21925514-5	2011	KEY FINDINGS: In heparinized blood, glibenclamide reduced LPS-induced release of IL-1 beta and TNF-alpha, tissue factor and PAI-2 mRNA in a concentration-dependent manner.	Glyburide	36-49	interleukin 1 beta	Homo sapiens	81-90
21925514-8	2011	IL-1 beta mRNA inhibition by glibenclamide appeared to be dependent on P2X7-receptor activation of monocytes by ATP-releasing erythrocytes during hypoxia.	Glyburide	29-42	interleukin 1 beta	Homo sapiens	0-9
21683339-7	2011	The expression levels of COX-2 and PGE(2) were enhanced by exogenous IL-1beta in chondrocytes.	Prostaglandins E	35-38	interleukin 1 beta	Homo sapiens	69-77
22051322-11	2011	RESULTS: In macrophages and PBL, RHP and GLGPG inhibited NO and PGE(2) production and reduced the secretion of cytokines (TNF-alpha, IFN-gamma, IL-1beta, IL-6, IL-12) and chemokines (CCL5/RANTES, CXCL10/IP-10).	glgpg	41-46	interleukin 1 beta	Homo sapiens	144-152
21683339-9	2011	It is shown that the expression of COX-2/PGE(2) was enhanced by IL-1beta in articular chondrocytes from mandibular condyle, and that MMP-1, -3, and -13 were induced by PGE(2), suggesting that IL-1beta-induced COX-2/PGE(2) play a crucial role in catabolic processes of mandibular condylar cartilage under inflammatory conditions.	Prostaglandins E	41-44	interleukin 1 beta	Homo sapiens	64-72
21683339-9	2011	It is shown that the expression of COX-2/PGE(2) was enhanced by IL-1beta in articular chondrocytes from mandibular condyle, and that MMP-1, -3, and -13 were induced by PGE(2), suggesting that IL-1beta-induced COX-2/PGE(2) play a crucial role in catabolic processes of mandibular condylar cartilage under inflammatory conditions.	Prostaglandins E	41-44	interleukin 1 beta	Homo sapiens	192-200
21683339-9	2011	It is shown that the expression of COX-2/PGE(2) was enhanced by IL-1beta in articular chondrocytes from mandibular condyle, and that MMP-1, -3, and -13 were induced by PGE(2), suggesting that IL-1beta-induced COX-2/PGE(2) play a crucial role in catabolic processes of mandibular condylar cartilage under inflammatory conditions.	Prostaglandins E	168-171	interleukin 1 beta	Homo sapiens	192-200
21683339-9	2011	It is shown that the expression of COX-2/PGE(2) was enhanced by IL-1beta in articular chondrocytes from mandibular condyle, and that MMP-1, -3, and -13 were induced by PGE(2), suggesting that IL-1beta-induced COX-2/PGE(2) play a crucial role in catabolic processes of mandibular condylar cartilage under inflammatory conditions.	Prostaglandins E	168-171	interleukin 1 beta	Homo sapiens	192-200
21945458-0	2011	Sodium dl-alpha-tocopheryl-6-O-phosphate inhibits PGE2 production in keratinocytes induced by UVB, IL-1beta and peroxidants.	sodium dl-alpha-tocopheryl-6-o-phosphate	0-40	interleukin 1 beta	Homo sapiens	99-107
21945458-0	2011	Sodium dl-alpha-tocopheryl-6-O-phosphate inhibits PGE2 production in keratinocytes induced by UVB, IL-1beta and peroxidants.	Dinoprostone	50-54	interleukin 1 beta	Homo sapiens	99-107
21945458-5	2011	In normal human epidermal keratinocytes stimulated with UVB irradiation, or exposed to interleukin-1 beta, tert-butylhydroperoxide or hydrogen peroxide, pre-treatment with 1 (0-2 muM) inhibited PGE(2) production in dose-dependent manner to a greater extent than 2 and 3.	Prostaglandins E	194-197	interleukin 1 beta	Homo sapiens	87-105
21940680-6	2011	In turn, reactive oxygen species derived from NAD(P)H oxidase promote the association of thioredoxin-interacting protein with the nucleotide-binding oligomerization domain-like receptor protein NLRP3 and subsequently induce inflammasome activation and IL-1beta secretion from the EC.	Reactive Oxygen Species	9-32	interleukin 1 beta	Homo sapiens	252-260
22147229-0	2011	Effect of titanium surface on secretion of IL1beta and TGFbeta1 by mononuclear cells.	Titanium	10-18	interleukin 1 beta	Homo sapiens	43-50
22147229-3	2011	The aim of this in vitro study was to evaluate the effects of commercially available titanium surface treatments on both cell viability and the secretion of the antagonist cytokines, IL1beta and TGFbeta1.	Titanium	85-93	interleukin 1 beta	Homo sapiens	183-190
21862613-3	2011	Our previous studies demonstrated that the ceramides activate the Nod-like receptor family, pyrin domain containing 3 (Nlrp3) inflammasome to cause the generation of mature IL-1beta and ablation of the Nlrp3 inflammasome in diet-induced obesity improves insulin signaling.	Ceramides	43-52	interleukin 1 beta	Homo sapiens	173-181
21704648-4	2011	Furthermore, the release and expression levels of inflammatory cytokines; including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) were also attenuated by COS.	oligochitosan	203-206	interleukin 1 beta	Homo sapiens	150-167
21704648-4	2011	Furthermore, the release and expression levels of inflammatory cytokines; including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) were also attenuated by COS.	oligochitosan	203-206	interleukin 1 beta	Homo sapiens	169-177
22126015-5	2011	Use of specific chemical inhibitors for JAK1 kinase (piceatannol), JAK2 kinase (AG-490), MEK1/2 (PD98059) and JNK1/2 (SP600125) revealed that IL-1beta-induced iNOS expression involved signaling pathways in addition to JAK-STAT and ERK1/2-JNK1/2 activation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	97-104	interleukin 1 beta	Homo sapiens	142-150
22126015-5	2011	Use of specific chemical inhibitors for JAK1 kinase (piceatannol), JAK2 kinase (AG-490), MEK1/2 (PD98059) and JNK1/2 (SP600125) revealed that IL-1beta-induced iNOS expression involved signaling pathways in addition to JAK-STAT and ERK1/2-JNK1/2 activation.	pyrazolanthrone	118-126	interleukin 1 beta	Homo sapiens	142-150
21913870-6	2011	The results show microencapsulated dexamethasone inhibited tumor necrosis factor-alpha (TNF-alpha) and interleukin-beta (IL-1beta) significantly in comparison with the solution form of dexamethasone.	Dexamethasone	35-48	interleukin 1 beta	Homo sapiens	121-129
21913870-9	2011	This study demonstrates significantly improved inhibition of TNF-alpha and IL-1beta both in vivo and in vitro when dexamethasone was used in microencapsulated form.	Dexamethasone	115-128	interleukin 1 beta	Homo sapiens	75-83
21719574-4	2011	Propolin D also significantly reduced the apoptosis of infected macrophage-like U937 cells and moderately reduced the secretion of interleukin (IL)-1beta and IL-18, which probably resulted from the inhibition of invasion plasmid antigen B secretion by this compound.	nymphaeol B	0-10	interleukin 1 beta	Homo sapiens	131-153
21704193-5	2011	3,4,5-Tricaffeoylquinic acid inhibited the TNF-alpha-stimulated production of cytokines (IL-1beta and IL-8) and chemokine (CCL17 and CCL27) in keratinocytes.	caffeoylquinic acid	0-28	interleukin 1 beta	Homo sapiens	89-97
21935932-8	2011	Neutralizing IL-1beta abolished the induction of MMP1 and MMP3 in preadipocytes by MC medium while the effects of TNFalpha neutralization were modest.	mc medium	83-92	interleukin 1 beta	Homo sapiens	13-21
21873375-7	2011	By real-time PCR, we report the first evidences for a DON-induced central inflammation, attested by the strong upregulation of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, cyclooxygenase-2, and microsomal prostaglandin synthase-1 (mPGES-1) messenger RNA.	deoxynivalenol	54-57	interleukin 1 beta	Homo sapiens	127-144
21838782-4	2011	The anti-inflammatory activities of 15-A(3t)-IsoP were observed in response not only to lipopolysaccharide, but also to tumor necrosis factor alpha and IL-1b stimulation.	15-a(3t)-isop	36-49	interleukin 1 beta	Homo sapiens	152-157
20473500-8	2011	SMV mitigated PG-induced increase in RhoA activity and NF-kappaB activation as well as secretion of TNFalpha and IL-1beta.	Simvastatin	0-3	interleukin 1 beta	Homo sapiens	113-121
21988719-2	2011	In macrophages and similar myeloid cells primed by lipopolysaccharide (LPS), activation of P2X7 by extracellular ATP opens a cation channel/pore allowing massive K+ efflux associated with processing and secretion of pro-inflammatory cytokines interleukin (IL)-1beta and IL-18.	Adenosine Triphosphate	113-116	interleukin 1 beta	Homo sapiens	243-265
21400614-11	2011	IL-1beta-511 TT genotype is associated with reduced susceptibility to CIHM especially in younger generation.	cihm	70-74	interleukin 1 beta	Homo sapiens	0-8
22015869-10	2011	The antiphospholipid antibody-induced cytokine changes were best reversed with LMW heparin, with partial reversal of IL-8 and IL-1beta upregulation.	Heparin, Low-Molecular-Weight	79-90	interleukin 1 beta	Homo sapiens	126-134
21982776-0	2011	Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1beta secretion.	polyphenol epigallocatechin-3-gallate	10-47	interleukin 1 beta	Homo sapiens	106-114
21878375-4	2011	Moreover, in IL-1beta-stimulated confluent-cells, DMSO dose-dependently reduced COX-2-derived PGE(2) (P&lt;0.05).	Dimethyl Sulfoxide	50-54	interleukin 1 beta	Homo sapiens	13-21
21878375-4	2011	Moreover, in IL-1beta-stimulated confluent-cells, DMSO dose-dependently reduced COX-2-derived PGE(2) (P&lt;0.05).	Prostaglandins E	94-97	interleukin 1 beta	Homo sapiens	13-21
21878375-1	2011	This study aimed to investigate dose effects of dimethyl sulfoxide (DMSO) (0.05-1%) on the intestinal inflammatory response in confluent- and differentiated-Caco-2 cells stimulated with interleukin (IL)-1beta or a pro-inflammatory cocktail for 24 h. Cyclooxygenase-2 (COX-2) activity was assayed by incubating inflamed cells with arachidonic acid and then measuring prostaglandin-E(2) (PGE(2)) produced.	Dimethyl Sulfoxide	48-66	interleukin 1 beta	Homo sapiens	186-208
21878375-5	2011	DMSO at 0.5% decreased significantly mRNA levels of 14 proteins involved in the inflammatory response (including IL-6, IL-1alpha, IL-1beta, and COX-2).	Dimethyl Sulfoxide	0-4	interleukin 1 beta	Homo sapiens	130-138
21982776-4	2011	In the search for mechanisms of EGCG-mediated melanoma cell suppression, we found that NF-kappaB was inhibited, and that reduced NF-kappaB activity was associated with decreased IL-1beta secretion from melanoma cells.	epigallocatechin gallate	32-36	interleukin 1 beta	Homo sapiens	178-186
21982776-5	2011	Since inflammasomes are involved in IL-1beta secretion, we investigated whether IL-1beta suppression was mediated by inflammasomes, and found that EGCG treatment led to downregulation of the inflammasome component, NLRP1, and reduced caspase-1 activation.	epigallocatechin gallate	147-151	interleukin 1 beta	Homo sapiens	36-44
21982776-5	2011	Since inflammasomes are involved in IL-1beta secretion, we investigated whether IL-1beta suppression was mediated by inflammasomes, and found that EGCG treatment led to downregulation of the inflammasome component, NLRP1, and reduced caspase-1 activation.	epigallocatechin gallate	147-151	interleukin 1 beta	Homo sapiens	80-88
21982776-7	2011	This paper provides a novel mechanism for EGCG-induced melanoma inhibition: inflammasome downregulation decreased IL-1beta secretion decreased NF-kappaB activities decreased cell growth.	epigallocatechin gallate	42-46	interleukin 1 beta	Homo sapiens	114-122
21916432-0	2011	Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-beta from induced inflammasomes.	berkeleyones	0-12	interleukin 1 beta	Homo sapiens	110-128
21916432-0	2011	Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-beta from induced inflammasomes.	meroterpenes	25-37	interleukin 1 beta	Homo sapiens	110-128
21916432-0	2011	Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-beta from induced inflammasomes.	water acid	50-60	interleukin 1 beta	Homo sapiens	110-128
22004293-11	2011	Inhibition of Hsp90beta by the chemicals Geldanamycin (GA) and Novobiocin (NB) caused a dose-dependent decrease of the NO production induced by IL-1beta in chondrocytes, up to basal levels.	geldanamycin	41-53	interleukin 1 beta	Homo sapiens	144-152
22020553-6	2011	A p38 MAPK inhibitor together with either an inhibitor of IkappaB kinase or a chelator of poorly liganded iron yielded synergistic inhibition of macrophage IL-1beta expression.	Iron	106-110	interleukin 1 beta	Homo sapiens	156-164
22004293-11	2011	Inhibition of Hsp90beta by the chemicals Geldanamycin (GA) and Novobiocin (NB) caused a dose-dependent decrease of the NO production induced by IL-1beta in chondrocytes, up to basal levels.	geldanamycin	55-57	interleukin 1 beta	Homo sapiens	144-152
22004293-11	2011	Inhibition of Hsp90beta by the chemicals Geldanamycin (GA) and Novobiocin (NB) caused a dose-dependent decrease of the NO production induced by IL-1beta in chondrocytes, up to basal levels.	Novobiocin	63-73	interleukin 1 beta	Homo sapiens	144-152
21951854-4	2011	Treatment of HeLa cells with 5-aza-dC, an inhibitor of DNA methylation, abolished the repression of IL-1beta-induced MCP-1 expression by hypoxia.	Decitabine	29-37	interleukin 1 beta	Homo sapiens	100-108
21839074-4	2011	Serum proinflammatory cytokines such as IL-1beta, IL-6, TNF-alpha and GM-CSF and also serum NO levels were significantly reduced by the treatment of nomilin.	nomilin	149-156	interleukin 1 beta	Homo sapiens	40-48
21862584-8	2011	Furthermore, blocking the p38 MAPK signaling pathway with SB203580 abolished the effect of IL-1beta-induced cPLA(2)alpha gene expression.	SB 203580	58-66	interleukin 1 beta	Homo sapiens	91-99
21862584-10	2011	Mutation of HuR Thr-118 reduced the association between HuR and cPLA(2)alpha mRNA under IL-1beta treatment.	Threonine	16-19	interleukin 1 beta	Homo sapiens	88-96
22003330-4	2011	Extracellular ATP associated with neuro- and glio-transmission, acting via purine type 2 receptors, e.g., the P2X7 receptor, has a role in glia release of IL1 and TNF.	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	155-158
21951854-8	2011	Our findings suggest that changes in the methylation status of CpGs, as well as histone 3 methylation, may represent a critical event in transcriptional repression of IL-1beta-induced MCP-1 expression by hypoxia.	cytidylyl-3'-5'-guanosine	63-67	interleukin 1 beta	Homo sapiens	167-175
21992677-12	2011	Using a luciferase promoter assay, our studies showed that parthenolide decreased activation of the IL-8 promoter in CF cells stimulated with TNFalpha/IL-1beta.	parthenolide	59-71	interleukin 1 beta	Homo sapiens	151-159
21982649-4	2011	Canakinumab is a human monoclonal antibody that selectively neutralizes IL-1beta, a proinflammatory cytokine that plays multiple roles in the atherothrombotic process and that undergoes activation by the nucleotide-binding leucine-rich repeat-containing pyrin receptor 3 inflammasome, a process promoted by cholesterol crystals.	Cholesterol	307-318	interleukin 1 beta	Homo sapiens	72-80
21762115-0	2011	Increased IL-1beta reactivity upon a glucose challenge in patients with deliberate self-harm.	Glucose	37-44	interleukin 1 beta	Homo sapiens	10-18
21762115-4	2011	We investigated the hypothesis that the levels of IL-1beta would be increased in these patients, because this might explain the aberrant glucose metabolism and add further knowledge to the aetiology of self-inflicted aggressive behaviour.	Glucose	137-144	interleukin 1 beta	Homo sapiens	50-58
21762115-10	2011	The increase in IL-1beta levels in response to glucose was significantly greater in patients than in controls.	Glucose	47-54	interleukin 1 beta	Homo sapiens	16-24
21347685-0	2011	Single nucleotide polymorphisms in the promoter region of the IL1B gene influence outcome in multiple myeloma patients treated with high-dose chemotherapy independently of relapse treatment with thalidomide and bortezomib.	Thalidomide	195-206	interleukin 1 beta	Homo sapiens	62-66
21297080-7	2011	Methemoglobin, a scavenger of endogenous H(2)S, increased DNA synthesis induced by FCS and IL-1beta.	Hydrogen Sulfide	41-46	interleukin 1 beta	Homo sapiens	91-99
21481060-6	2011	IL-1beta and TNF-alpha, but not IFN-gamma production, was reduced by 21% O(2) .	Oxygen	73-77	interleukin 1 beta	Homo sapiens	0-8
21347685-0	2011	Single nucleotide polymorphisms in the promoter region of the IL1B gene influence outcome in multiple myeloma patients treated with high-dose chemotherapy independently of relapse treatment with thalidomide and bortezomib.	Bortezomib	211-221	interleukin 1 beta	Homo sapiens	62-66
21338323-5	2011	Pre-incubation with metformin (24 h, 1 mM) inhibited forskolin-, isoproterenol-, IBMX-, LPS-, IL-1beta- and TNF-alpha-induced glycerol release and prevented p(Ser554)HSL decrease and p(Ser-552)HSL increase due to lipolytic and inflammatory agents.	Metformin	20-29	interleukin 1 beta	Homo sapiens	94-102
21338323-5	2011	Pre-incubation with metformin (24 h, 1 mM) inhibited forskolin-, isoproterenol-, IBMX-, LPS-, IL-1beta- and TNF-alpha-induced glycerol release and prevented p(Ser554)HSL decrease and p(Ser-552)HSL increase due to lipolytic and inflammatory agents.	Glycerol	126-134	interleukin 1 beta	Homo sapiens	94-102
21702012-12	2011	Up-regulation of cPLA2 by IL-1beta increased PGE(2) biosynthesis in RASFs.	Dinoprostone	45-51	interleukin 1 beta	Homo sapiens	26-34
21702012-0	2011	Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1beta via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-kappaB activity in human rheumatoid arthritis synovial fibroblasts.	Dinoprostone	41-57	interleukin 1 beta	Homo sapiens	69-86
21702012-8	2011	RESULTS: IL-1beta-induced cPLA2 expression and PGE2 release were mediated through a myeloid differentiation factor 88 (MyD88)/c-Src-dependent matrix metalloproteinase (MMP)/heparin-binding epidermal growth factor (HB-EGF) cascade linking to transactivation of the EGF receptor (EGFR)/phosphatidylinositol 3-kinase (PI 3-kinase)/Akt, p300, and NF-kappaB p65 pathways.	Dinoprostone	47-51	interleukin 1 beta	Homo sapiens	9-17
21724580-6	2011	In the vitamin D(3) supplementation group, TNF-alpha decreased 13%, IL-6 32%, IL-1beta 50%, and IL-8 15%; in the calcium supplementation group, IL-6 decreased 37%, IL-8 11%, and IL-1beta 27%.	Vitamin D	7-16	interleukin 1 beta	Homo sapiens	178-186
21415860-6	2011	Furthermore, the release of AA and the production of IL-1beta induced by proinflammatory stimuli, such as TNF-alpha, LPS, and poly I/C, are severely decreased in Prdx6(KD) cells.	poly	126-130	interleukin 1 beta	Homo sapiens	53-61
21939359-9	2011	In addition, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2, and IL-1beta on treatment with eugenol.	Eugenol	169-176	interleukin 1 beta	Homo sapiens	142-150
21828177-0	2011	IL-1beta stimulates activin betaA mRNA expression in human skin fibroblasts through the MAPK pathways, the nuclear factor-kappaB pathway, and prostaglandin E2.	Dinoprostone	142-158	interleukin 1 beta	Homo sapiens	0-8
21797848-9	2011	The induction of interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha release, but not IL-10 release, in response to TCP-353 peptide was enhanced in CD mononuclear cells only.	N-(3,4,5-trichlorophenyl)succinimide	132-135	interleukin 1 beta	Homo sapiens	17-39
21828177-3	2011	IL-1beta increased activin betaA (INHBA) and follistatin (FST) mRNA expression within 6 h. A p38 MAPK inhibitor, SB202190, a MAPK/ERK kinase inhibitor, U0126, and an nuclear factor kappaB pathway inhibitor, SC-514, significantly suppressed the IL-1beta-stimulated INHBA and FST mRNA expression.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	113-121	interleukin 1 beta	Homo sapiens	0-8
21828177-3	2011	IL-1beta increased activin betaA (INHBA) and follistatin (FST) mRNA expression within 6 h. A p38 MAPK inhibitor, SB202190, a MAPK/ERK kinase inhibitor, U0126, and an nuclear factor kappaB pathway inhibitor, SC-514, significantly suppressed the IL-1beta-stimulated INHBA and FST mRNA expression.	U 0126	152-157	interleukin 1 beta	Homo sapiens	0-8
21828177-3	2011	IL-1beta increased activin betaA (INHBA) and follistatin (FST) mRNA expression within 6 h. A p38 MAPK inhibitor, SB202190, a MAPK/ERK kinase inhibitor, U0126, and an nuclear factor kappaB pathway inhibitor, SC-514, significantly suppressed the IL-1beta-stimulated INHBA and FST mRNA expression.	SC 514	207-213	interleukin 1 beta	Homo sapiens	0-8
21828177-4	2011	A prostaglandin-endoperoxide synthase inhibitor indomethacin, a potent inhibitor of prostaglandin E(2) (PGE(2)) synthesis, also significantly suppressed the IL-1beta-stimulated INHBA but not FST mRNA expression.	Indomethacin	48-60	interleukin 1 beta	Homo sapiens	157-165
21828177-4	2011	A prostaglandin-endoperoxide synthase inhibitor indomethacin, a potent inhibitor of prostaglandin E(2) (PGE(2)) synthesis, also significantly suppressed the IL-1beta-stimulated INHBA but not FST mRNA expression.	Dinoprostone	84-102	interleukin 1 beta	Homo sapiens	157-165
21828177-4	2011	A prostaglandin-endoperoxide synthase inhibitor indomethacin, a potent inhibitor of prostaglandin E(2) (PGE(2)) synthesis, also significantly suppressed the IL-1beta-stimulated INHBA but not FST mRNA expression.	Prostaglandins E	104-107	interleukin 1 beta	Homo sapiens	157-165
21828177-9	2011	In summary, the present study indicates that the p38 MAPK, the MAPK/ERK kinase, the nuclear factor kappaB pathway, and PGE(2) mediate the effects of IL-1beta on INHBA mRNA expression.	Prostaglandins E	119-122	interleukin 1 beta	Homo sapiens	149-157
22165113-0	2011	[Effect of different porcelain-fused-to-metal crown inner metal materials on the level of soluble intercellular adhesion molecule-1 and interleukin-1beta in gingival crevicular fluid].	Metals	58-63	interleukin 1 beta	Homo sapiens	136-153
21687998-6	2011	RESULTS: Both the rhIL-1ra and the APS reduced the effect of IL-1beta on human macrophages in vitro.	aps	35-38	interleukin 1 beta	Homo sapiens	61-69
21687998-9	2011	CONCLUSION: The ability of the APS to reduce the effect of IL-1beta and limit the expression of other inflammatory cytokines in vitro validates its potential use as an autologous treatment for osteoarthritis.	aps	31-34	interleukin 1 beta	Homo sapiens	59-67
21119093-5	2011	Bezafibrate treatment normalized monocyte release of MCP-1, interleukin-6, TNF-alpha, and interleukin-1beta and also normalized plasma hsCRP levels in mixed dyslipidemic subjects, whereas in IFG individuals the drug reduced only MCP-1 and interleukin-6 release.	Bezafibrate	0-11	interleukin 1 beta	Homo sapiens	90-107
22000485-7	2011	Our results reveal a potential role of IL-1 signaling in acute DOX-induced cardiotoxic injury and lead to an assumption that this signal system might be a potential candidate agent that inhibits cardiomyocyte-toxicity in DOX-exposed patients.	Doxorubicin	63-66	interleukin 1 beta	Homo sapiens	39-43
22000485-7	2011	Our results reveal a potential role of IL-1 signaling in acute DOX-induced cardiotoxic injury and lead to an assumption that this signal system might be a potential candidate agent that inhibits cardiomyocyte-toxicity in DOX-exposed patients.	Doxorubicin	221-224	interleukin 1 beta	Homo sapiens	39-43
20697789-0	2011	Adrenomedullin inhibits IL-1beta-induced rheumatoid synovial fibroblast proliferation and MMPs, COX-2 and PGE2 production.	Dinoprostone	106-110	interleukin 1 beta	Homo sapiens	24-32
22230393-7	2011	Finally, in comparison to previous experiments carried out with TNF-alpha and IL-1beta, we have shown that paraquat produced a similar pattern of activation of set of genes involved both in inflammation and apoptosis.	Paraquat	107-115	interleukin 1 beta	Homo sapiens	78-86
21615409-2	2011	We comprehensively assessed the involvement of MAPKs, activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) in IL-1beta-induced production of interleukin-6 (IL-6), interleukin-8 (IL-8), prostaglandin E(2) (PGE(2) ) and MMP-1 in human periodontal ligament cells.	Prostaglandins E	197-212	interleukin 1 beta	Homo sapiens	122-130
21615409-2	2011	We comprehensively assessed the involvement of MAPKs, activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) in IL-1beta-induced production of interleukin-6 (IL-6), interleukin-8 (IL-8), prostaglandin E(2) (PGE(2) ) and MMP-1 in human periodontal ligament cells.	Prostaglandins E	217-220	interleukin 1 beta	Homo sapiens	122-130
21615409-6	2011	Furthermore, IL-1beta stimulated the production of IL-6, IL-8, PGE(2) and MMP-1 via activation of the three MAPKs and NF-kappaB, because inhibitors of these significantly suppressed the IL-1beta-stimulated production of these factors.	Prostaglandins E	63-66	interleukin 1 beta	Homo sapiens	13-21
21615409-7	2011	CONCLUSION: Our results strongly suggest that MAPK, AP-1 and NF-kappaB mediate the IL-1beta-stimulated synthesis of IL-6, IL-8, PGE(2) and MMP-1 in human periodontal ligament cells.	Prostaglandins E	128-131	interleukin 1 beta	Homo sapiens	83-91
21744278-5	2011	SP600125 attenuated t10,c12 CLA-mediated induction of inflammatory genes, including interleukin (IL)-6, IL-8, IL-1beta, ATF3, monocyte chemoattractant protein (MCP)-1, and cyclooxygenase-2.	pyrazolanthrone	0-8	interleukin 1 beta	Homo sapiens	110-118
21791628-9	2011	In an acute smoke model, AZD9668 reduced the inflammatory response to cigarette smoke as indicated by a reduction in BAL neutrophils and interleukin-1beta.	N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide	25-32	interleukin 1 beta	Homo sapiens	137-154
21447989-0	2011	Diabetic Retinopathy Is Associated with Decreased Tyrosine Nitrosylation of Vitreous Interleukins IL-1alpha, IL-1beta, and IL-7.	Tyrosine	50-58	interleukin 1 beta	Homo sapiens	109-117
21943782-3	2011	Compared with the placebo plus MTX group, serum levels of IL-17, IFN-gamma, IL-21 and IL-1beta significantly decreased, the percentages of Th17 cells and Th1 cells were lower and the percentage of Treg cells was higher after receiving Anakinra combined with MTX treatment.	Methotrexate	31-34	interleukin 1 beta	Homo sapiens	86-94
21763744-3	2011	Exposure to IL-1beta for 10 days increased (i) accumulation of 8-OHdG - a key biomarker of oxidative DNA damage; (ii) DNA damage response (DDR) indicators gammaH2AX, ATM and DNA-PK; (iii) nuclear and cytoplasmic p53 and COX-2 levels and (iv) interaction between COX-2 and p53.	8-ohdg	63-69	interleukin 1 beta	Homo sapiens	12-20
21763744-5	2011	COX-2 inhibitor Celecoxib reduced self renewal capacity and increased apoptosis of both control and IL-1beta treated CSCs.	Celecoxib	16-25	interleukin 1 beta	Homo sapiens	100-108
21708940-7	2011	The mechanisms of PP2A activation by IL-1beta involved neutral sphingomyelinase-2 (NSMase-2) and an accumulation of ceramide.	Ceramides	116-124	interleukin 1 beta	Homo sapiens	37-45
21934447-7	2011	The combination of poly (inosinic acid:cytidylic acid) and lactic acid markedly increased IL-8 production (5.0 ng/mL) and induced the release of IL-1beta (96.2 pg/mL).	Poly I	19-38	interleukin 1 beta	Homo sapiens	145-153
21934447-7	2011	The combination of poly (inosinic acid:cytidylic acid) and lactic acid markedly increased IL-8 production (5.0 ng/mL) and induced the release of IL-1beta (96.2 pg/mL).	Cytidine Monophosphate	39-53	interleukin 1 beta	Homo sapiens	145-153
21934447-7	2011	The combination of poly (inosinic acid:cytidylic acid) and lactic acid markedly increased IL-8 production (5.0 ng/mL) and induced the release of IL-1beta (96.2 pg/mL).	Lactic Acid	59-70	interleukin 1 beta	Homo sapiens	145-153
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Poly I	4-23	interleukin 1 beta	Homo sapiens	71-79
21587103-6	2011	METHODS: In part 1, the anti-inflammatory and anticatabolic effect of resveratrol was investigated in a cell culture model on interleukin 1beta (IL-1beta) prestimulated human IVD cells on the gene and protein expression level.	Resveratrol	70-81	interleukin 1 beta	Homo sapiens	126-143
21587103-6	2011	METHODS: In part 1, the anti-inflammatory and anticatabolic effect of resveratrol was investigated in a cell culture model on interleukin 1beta (IL-1beta) prestimulated human IVD cells on the gene and protein expression level.	Resveratrol	70-81	interleukin 1 beta	Homo sapiens	145-153
22039321-7	2011	Treatment with NO-ASA dose-dependently accelerated colonic healing followed by a rise in plasma NO(x) content and CBF, suppression of MPO and downregulation of COX-2, iNOS, IL-1beta and TNF-alpha mRNAs.	Aspirin	18-21	interleukin 1 beta	Homo sapiens	173-181
21943001-10	2011	Finally, inhibition of either of these ROS-induced signaling pathways suppressed cytokine (TNF-alpha and IL-1beta) production, while chemokine (CCL2 and CXCL10) induction pathways were sensitive to inhibition of p38, but not ERK1/2 MAPK.	Reactive Oxygen Species	39-42	interleukin 1 beta	Homo sapiens	105-113
21664353-11	2011	A further proof was achieved by DEX inhibition for IL1-beta-stimulated IL-6 and COX-2 gene expression.	Dexamethasone	32-35	interleukin 1 beta	Homo sapiens	51-59
21673342-5	2011	gammadelta T cell-independent NK cell activation in response to zoledronate was because of downstream depletion of endogenous prenyl pyrophosphates and subsequent caspase-1 activation in DC-like cells, which then provide mature IL-18 and IL-1beta for the activation of IL-2-primed NK cells.	Zoledronic Acid	64-75	interleukin 1 beta	Homo sapiens	238-246
22092168-8	2011	RESULTS: NAC infusion patients had significantly lower post-operative concentrations of myocardial-specific protein [cTnI, CPK-MB] and pro-inflammatory cytokines [TNF-alpha, IL-1beta].	Acetylcysteine	9-12	interleukin 1 beta	Homo sapiens	174-182
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Cytidine Monophosphate	24-39	interleukin 1 beta	Homo sapiens	71-79
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Lactic Acid	49-60	interleukin 1 beta	Homo sapiens	71-79
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Lactic Acid	120-131	interleukin 1 beta	Homo sapiens	71-79
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Acetic Acid	154-165	interleukin 1 beta	Homo sapiens	71-79
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Lactic Acid	120-131	interleukin 1 beta	Homo sapiens	71-79
21807015-4	2011	Our results showed that among the tested molecules, all sensitizers specifically prevent the production of PMA/LPS-induced COX-2 metabolites (PGE(2,) TxB(2) and PGD(2)), eugenol and cinnamaldehyde inhibiting also the production of IL-1beta and TNF-alpha.	Tetradecanoylphorbol Acetate	107-110	interleukin 1 beta	Homo sapiens	231-239
21762793-3	2011	Data now indicate that the proinflammatory cytokine interleukin (IL)-1beta impairs respiration during infection via prostaglandin E2 (PGE(2)) and that infection, with associated eicosanoid release, is one of the main causes of respiratory disorders in preterm infants.	Dinoprostone	116-132	interleukin 1 beta	Homo sapiens	52-74
21762793-3	2011	Data now indicate that the proinflammatory cytokine interleukin (IL)-1beta impairs respiration during infection via prostaglandin E2 (PGE(2)) and that infection, with associated eicosanoid release, is one of the main causes of respiratory disorders in preterm infants.	Prostaglandins E	134-137	interleukin 1 beta	Homo sapiens	52-74
21762793-3	2011	Data now indicate that the proinflammatory cytokine interleukin (IL)-1beta impairs respiration during infection via prostaglandin E2 (PGE(2)) and that infection, with associated eicosanoid release, is one of the main causes of respiratory disorders in preterm infants.	Eicosanoids	178-188	interleukin 1 beta	Homo sapiens	52-74
21821055-10	2011	SIGNIFICANCE: In this study, we demonstrate that both DMSO and DMS represent strong anti-inflammatory properties by blocking constitutive as well as IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.	Dimethyl Sulfoxide	54-58	interleukin 1 beta	Homo sapiens	149-157
21821055-10	2011	SIGNIFICANCE: In this study, we demonstrate that both DMSO and DMS represent strong anti-inflammatory properties by blocking constitutive as well as IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.	dimethyl sulfone	54-57	interleukin 1 beta	Homo sapiens	149-157
21177981-8	2011	However, the exposure of hMo-DCs matured with TNF-alpha + IL-1beta to Lda-BK for 6 hours decreased subsequent migration in response to Lda-BK, the chemokine CCL19, or Lda-BK combined with CCL19.	Berkelium	73-76	interleukin 1 beta	Homo sapiens	58-66
21684332-11	2011	Interestingly, the inflammasome activator monosodium urate crystals (MSU) induced the release of CXCL-8 and IL-1beta and the caspase-1 inhibitor Z-VADDCB suppressed the CS-induced release of CXCL-8.	SODIUM URATE	42-67	interleukin 1 beta	Homo sapiens	108-116
21684332-5	2011	Here we demonstrate that CS induces the release of CXCL-8 and IL-1beta from human bronchial epithelial cells (HBE-14o).	Cesium	25-27	interleukin 1 beta	Homo sapiens	62-70
21684332-11	2011	Interestingly, the inflammasome activator monosodium urate crystals (MSU) induced the release of CXCL-8 and IL-1beta and the caspase-1 inhibitor Z-VADDCB suppressed the CS-induced release of CXCL-8.	msu	69-72	interleukin 1 beta	Homo sapiens	108-116
21684332-12	2011	In addition, CS, CpGODN, lipopolysaccharide and MSU all increased the expression of caspase-1 and IL-1beta.	Cesium	13-15	interleukin 1 beta	Homo sapiens	98-106
21684332-12	2011	In addition, CS, CpGODN, lipopolysaccharide and MSU all increased the expression of caspase-1 and IL-1beta.	CPG-oligonucleotide	17-23	interleukin 1 beta	Homo sapiens	98-106
21684332-12	2011	In addition, CS, CpGODN, lipopolysaccharide and MSU all increased the expression of caspase-1 and IL-1beta.	msu	48-51	interleukin 1 beta	Homo sapiens	98-106
21635197-3	2011	EXPERT OPINION: Ceramide participates in beta-cell dysfunction and apoptosis after exposure to TNFalpha, IL-1beta and IFN-gamma, excessive amyloid and islet amyloid polypeptide or non-esterified fatty acids (lipotoxicity).	Ceramides	16-24	interleukin 1 beta	Homo sapiens	105-113
21742595-8	2011	In addition, Th1 cytokines (TNF-alpha and IL-1beta) remarkably increased the expression of CCL20 in both NDF and SSDF in a dose- and time-dependent manner.	N-(CARBOXYCARBONYL)-D-PHENYLALANINE	105-108	interleukin 1 beta	Homo sapiens	42-50
21742595-8	2011	In addition, Th1 cytokines (TNF-alpha and IL-1beta) remarkably increased the expression of CCL20 in both NDF and SSDF in a dose- and time-dependent manner.	ssdf	113-117	interleukin 1 beta	Homo sapiens	42-50
21247370-6	2011	The IL-1beta-induced MMP-3 level was significantly and dose-dependently reduced by &gt;50% by the six plants (P &lt; 0.01: at 100  mug/ mL of CS and LH, P &lt; 0.001: at 10 mug/mL of all plants, and at 100 mug/mL of AC, BC, CF, and SS).	Cesium	142-144	interleukin 1 beta	Homo sapiens	4-12
21247370-6	2011	The IL-1beta-induced MMP-3 level was significantly and dose-dependently reduced by &gt;50% by the six plants (P &lt; 0.01: at 100  mug/ mL of CS and LH, P &lt; 0.001: at 10 mug/mL of all plants, and at 100 mug/mL of AC, BC, CF, and SS).	Luteinizing Hormone	149-151	interleukin 1 beta	Homo sapiens	4-12
21247370-6	2011	The IL-1beta-induced MMP-3 level was significantly and dose-dependently reduced by &gt;50% by the six plants (P &lt; 0.01: at 100  mug/ mL of CS and LH, P &lt; 0.001: at 10 mug/mL of all plants, and at 100 mug/mL of AC, BC, CF, and SS).	Actinium	216-218	interleukin 1 beta	Homo sapiens	4-12
21804018-8	2011	IRAK1/4 inhibitors, their small interfering RNAs, and JNK inhibitor also attenuated PMA-induced IL-1beta production.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 beta	Homo sapiens	96-104
21804018-4	2011	Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs.	Tetradecanoylphorbol Acetate	10-13	interleukin 1 beta	Homo sapiens	22-30
21535449-0	2011	Melatonin inhibits IL-1beta-induced monolayer permeability of human umbilical vein endothelial cells via Rac activation.	Melatonin	0-9	interleukin 1 beta	Homo sapiens	19-27
21804018-5	2011	Rottlerin, a PKCdelta-specific inhibitor, significantly reduced PMA-induced IL-1beta production as well as CD11b, TLR2 expression, and IRAK1-JNK activation.	rottlerin	0-9	interleukin 1 beta	Homo sapiens	76-84
21804018-5	2011	Rottlerin, a PKCdelta-specific inhibitor, significantly reduced PMA-induced IL-1beta production as well as CD11b, TLR2 expression, and IRAK1-JNK activation.	Tetradecanoylphorbol Acetate	64-67	interleukin 1 beta	Homo sapiens	76-84
21931204-3	2011	OBJECTIVE: The aim of this study was to evaluate the effect of Ibuprofen on IL-1beta, TNF-alpha and PGE2 levels in periapical exudates and compare the results with a group of placebo control.	Ibuprofen	63-72	interleukin 1 beta	Homo sapiens	76-84
21535449-4	2011	The aim of this study was to investigate the effect of melatonin on IL-1beta-induced human umbilical vein endothelial cells (HUVECs) monolayer permeability and then to test the involvement of small GTPase Rac in the melatonin-induced endothelial barrier-protective effects as well as cell contact reorganization.	Melatonin	55-64	interleukin 1 beta	Homo sapiens	68-76
21535449-4	2011	The aim of this study was to investigate the effect of melatonin on IL-1beta-induced human umbilical vein endothelial cells (HUVECs) monolayer permeability and then to test the involvement of small GTPase Rac in the melatonin-induced endothelial barrier-protective effects as well as cell contact reorganization.	Melatonin	216-225	interleukin 1 beta	Homo sapiens	68-76
21535449-7	2011	Furthermore, melatonin dramatically improved IL-1beta-induced Rac inactivation.	Melatonin	13-22	interleukin 1 beta	Homo sapiens	45-53
22299446-7	2011	However, at the same levels of glucose normal monocytes stimulated with S. aureus produce significantly higher IL-1beta than those stimulated with S. epidermidis.	Glucose	31-38	interleukin 1 beta	Homo sapiens	111-119
21295946-6	2011	Curcumin decreased secretion of IL-6 (P = 0.015) and IL-1 beta (P = 0.016).	Curcumin	0-8	interleukin 1 beta	Homo sapiens	53-62
21669872-6	2011	Herein, we used an in vitro model of human tenocytes to study the mechanism of curcumin action on IL-1beta-mediated inflammatory signaling.	Curcumin	79-87	interleukin 1 beta	Homo sapiens	98-106
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Hydrocortisone	38-46	interleukin 1 beta	Homo sapiens	19-27
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Androstenedione	48-63	interleukin 1 beta	Homo sapiens	19-27
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Dehydroepiandrosterone	65-87	interleukin 1 beta	Homo sapiens	19-27
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Dehydroepiandrosterone Sulfate	92-122	interleukin 1 beta	Homo sapiens	19-27
21854562-8	2011	Supporting these gene expression results, IL-1beta-induced cartilage matrix breakdown, as evidenced by GAG release from cartilage explants, was also significantly blocked (p &lt; 0.05).	Glycosaminoglycans	103-106	interleukin 1 beta	Homo sapiens	42-50
21854562-9	2011	Moreover, in the presence of herbal-Leucine mixture (HLM) up-regulation of ACAN and COL2A1 expression in IL-1beta-stimulated OA chondrocytes was also noted (p &lt; 0.05).	Leucine	36-43	interleukin 1 beta	Homo sapiens	105-113
21868363-6	2011	Tpl2 also promoted Ca(2+) signals and cell migration from sphingosine 1-phosphate-responsive GPCRs, which also couple to Galpha(i); from Wnt5a; and from the interleukin-1beta (IL-1beta) receptor, a member of the Toll-IL-1R (TIR) domain family.	sphingosine 1-phosphate	58-81	interleukin 1 beta	Homo sapiens	157-174
21868363-6	2011	Tpl2 also promoted Ca(2+) signals and cell migration from sphingosine 1-phosphate-responsive GPCRs, which also couple to Galpha(i); from Wnt5a; and from the interleukin-1beta (IL-1beta) receptor, a member of the Toll-IL-1R (TIR) domain family.	sphingosine 1-phosphate	58-81	interleukin 1 beta	Homo sapiens	176-184
21861859-4	2011	In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1beta-induced inflammatory cytokines, TNFalpha, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes.	epigallocatechin gallate	19-45	interleukin 1 beta	Homo sapiens	109-117
21669872-7	2011	Curcumin at concentrations of 5-20 mum inhibited IL-1beta-induced inflammation and apoptosis in cultures of human tenocytes.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	49-57
21861859-4	2011	In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1beta-induced inflammatory cytokines, TNFalpha, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes.	Polyphenols	59-69	interleukin 1 beta	Homo sapiens	109-117
21669872-11	2011	Curcumin suppressed IL-1beta-induced PI-3K p85/Akt activation and its association with IKK.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	20-28
21861859-5	2011	The use of green tea polyphenols may be beneficial as a therapeutic addition to biologics that control IL-1beta activity by increasing effectiveness and/or reducing dosage.	Polyphenols	21-32	interleukin 1 beta	Homo sapiens	103-111
21420486-5	2011	IFN-beta induced IL-27 expression by DC, and neutralisation of IL-27 abrogated the suppressive effects of IFN-beta on zymosan-induced IL-1 and IL-23 production and the generation of Th17 cells in vitro.	Zymosan	118-125	interleukin 1 beta	Homo sapiens	134-138
21628463-5	2011	Drugs blocking ROS production or the antioxidant response prevent the secretion of mature IL-1beta but not the biosynthesis of pro-IL-1beta, indicating that redox remodeling is responsible for IL-1beta processing and release.	Reactive Oxygen Species	15-18	interleukin 1 beta	Homo sapiens	90-98
21628463-8	2011	High doses (5 mM) of H(2)O(2) overcome the high antioxidant capacity of THP-1 cells, restore an efficient redox response, and increase the rate of IL-1beta secretion.	Hydrogen Peroxide	21-29	interleukin 1 beta	Homo sapiens	147-155
21506092-0	2011	Estrogen receptor-related receptor alpha regulation by interleukin-1beta in prostaglandin E(2)- and cAMP-dependent pathways in osteoarthritic chondrocytes.	Dinoprostone	76-94	interleukin 1 beta	Homo sapiens	55-72
21506092-0	2011	Estrogen receptor-related receptor alpha regulation by interleukin-1beta in prostaglandin E(2)- and cAMP-dependent pathways in osteoarthritic chondrocytes.	Cyclic AMP	100-104	interleukin 1 beta	Homo sapiens	55-72
21506092-5	2011	Interleukin-1beta (IL-1beta) markedly up-regulated ERRalpha expression in OA chondrocytes in vitro, and agonist or inhibitor treatment indicated that the up-regulation was dependent on cyclooxygenase 2 (COX-2; NS398), prostaglandin E(2), cAMP (8-bromo-cAMP), and protein kinase A (PKA; KT5720).	Prostaglandins E	218-233	interleukin 1 beta	Homo sapiens	0-17
21506092-5	2011	Interleukin-1beta (IL-1beta) markedly up-regulated ERRalpha expression in OA chondrocytes in vitro, and agonist or inhibitor treatment indicated that the up-regulation was dependent on cyclooxygenase 2 (COX-2; NS398), prostaglandin E(2), cAMP (8-bromo-cAMP), and protein kinase A (PKA; KT5720).	Prostaglandins E	218-233	interleukin 1 beta	Homo sapiens	19-27
21506092-5	2011	Interleukin-1beta (IL-1beta) markedly up-regulated ERRalpha expression in OA chondrocytes in vitro, and agonist or inhibitor treatment indicated that the up-regulation was dependent on cyclooxygenase 2 (COX-2; NS398), prostaglandin E(2), cAMP (8-bromo-cAMP), and protein kinase A (PKA; KT5720).	Cyclic AMP	238-242	interleukin 1 beta	Homo sapiens	0-17
21506092-5	2011	Interleukin-1beta (IL-1beta) markedly up-regulated ERRalpha expression in OA chondrocytes in vitro, and agonist or inhibitor treatment indicated that the up-regulation was dependent on cyclooxygenase 2 (COX-2; NS398), prostaglandin E(2), cAMP (8-bromo-cAMP), and protein kinase A (PKA; KT5720).	Cyclic AMP	238-242	interleukin 1 beta	Homo sapiens	19-27
21506092-5	2011	Interleukin-1beta (IL-1beta) markedly up-regulated ERRalpha expression in OA chondrocytes in vitro, and agonist or inhibitor treatment indicated that the up-regulation was dependent on cyclooxygenase 2 (COX-2; NS398), prostaglandin E(2), cAMP (8-bromo-cAMP), and protein kinase A (PKA; KT5720).	8-Bromo Cyclic Adenosine Monophosphate	244-256	interleukin 1 beta	Homo sapiens	0-17
21506092-5	2011	Interleukin-1beta (IL-1beta) markedly up-regulated ERRalpha expression in OA chondrocytes in vitro, and agonist or inhibitor treatment indicated that the up-regulation was dependent on cyclooxygenase 2 (COX-2; NS398), prostaglandin E(2), cAMP (8-bromo-cAMP), and protein kinase A (PKA; KT5720).	8-Bromo Cyclic Adenosine Monophosphate	244-256	interleukin 1 beta	Homo sapiens	19-27
21506092-6	2011	Treatment with the ERRalpha inverse agonist XCT790 decreased the expression of SOX9 and the up-regulation of ERRalpha by IL-1beta, suggesting autoregulation of ERRalpha in the IL-1beta pathway.	XCT790	44-50	interleukin 1 beta	Homo sapiens	121-129
21506092-6	2011	Treatment with the ERRalpha inverse agonist XCT790 decreased the expression of SOX9 and the up-regulation of ERRalpha by IL-1beta, suggesting autoregulation of ERRalpha in the IL-1beta pathway.	XCT790	44-50	interleukin 1 beta	Homo sapiens	176-184
21506092-8	2011	CONCLUSION: We report the first evidence that ERRalpha expression is regulated by IL-1beta in COX-2-, cAMP-, and PKA-dependent pathways in OA chondrocytes.	Cyclic AMP	102-106	interleukin 1 beta	Homo sapiens	82-90
21567074-10	2011	Prostaglandin (PG) and NO synthesis pathways were both affected by trauma and/or IL-1beta.	Prostaglandins	0-13	interleukin 1 beta	Homo sapiens	81-89
21884514-6	2011	Conversely, IL-23 plus IL-1beta partially opposed the PGE2-mediated repression of early interferon gamma (IFN-gamma) secretion from CD161(+) cells, as well as the PGE2-mediated depletion of IFN-gamma(+) CD161(+) cells.	Dinoprostone	54-58	interleukin 1 beta	Homo sapiens	23-31
21884514-6	2011	Conversely, IL-23 plus IL-1beta partially opposed the PGE2-mediated repression of early interferon gamma (IFN-gamma) secretion from CD161(+) cells, as well as the PGE2-mediated depletion of IFN-gamma(+) CD161(+) cells.	Dinoprostone	163-167	interleukin 1 beta	Homo sapiens	23-31
21932667-1	2011	OBJECTIVE: To observe the effect of lipopolysaccharide(LPS) and interleukin-1beta (IL-1beta) on the expression of inducible nitric oxide synthase (iNOS) gene and nitric oxide (NO) in human periodontal ligament cells (hPDLCs).	Nitric Oxide	124-136	interleukin 1 beta	Homo sapiens	64-81
21932667-1	2011	OBJECTIVE: To observe the effect of lipopolysaccharide(LPS) and interleukin-1beta (IL-1beta) on the expression of inducible nitric oxide synthase (iNOS) gene and nitric oxide (NO) in human periodontal ligament cells (hPDLCs).	Nitric Oxide	124-136	interleukin 1 beta	Homo sapiens	83-91
21439397-1	2011	OBJECTIVE: This study aimed to investigate the effect of betamethasone treatment on the endocervical concentration of IL-1beta, IL-4, IL-6, and TNF-alpha in preterm labor patients.	Betamethasone	57-70	interleukin 1 beta	Homo sapiens	118-126
21439397-5	2011	RESULTS: In the betamethasone group IL-1beta and TNF-alpha significantly decreased (P&lt;0.001), and IL-6 and IL-4 increased (P: NS).	Betamethasone	16-29	interleukin 1 beta	Homo sapiens	36-44
21567074-10	2011	Prostaglandin (PG) and NO synthesis pathways were both affected by trauma and/or IL-1beta.	Prostaglandins	15-17	interleukin 1 beta	Homo sapiens	81-89
21111593-7	2011	Whereas stigmasterol blunted aggregated LDL (agLDL) induced increases in tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta secretion, sitosterol exacerbated these effects.	Stigmasterol	8-20	interleukin 1 beta	Homo sapiens	131-139
21111593-7	2011	Whereas stigmasterol blunted aggregated LDL (agLDL) induced increases in tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta secretion, sitosterol exacerbated these effects.	agldl	45-50	interleukin 1 beta	Homo sapiens	131-139
21463327-10	2011	Only atorvastatin at the highest concentration (5x10(-6)  m) significantly increased the IL-1beta-stimulated RANKL/OPG ratio.	Atorvastatin	5-17	interleukin 1 beta	Homo sapiens	89-97
20599489-2	2011	MATERIALS AND METHODS: Primary human chondrocytes (PHC) were stimulated with IL-1beta or lipopolysaccharide (LPS) to induce the enhanced release of prostaglandin E(2) (PGE(2)), metalloproteinase (MMP-3 and -13), and cyclooxygenase-2 (COX-2) protein expression.	Prostaglandins E	148-163	interleukin 1 beta	Homo sapiens	77-85
21571945-5	2011	IL-1beta production in response to LPS was synergistically higher for both monocytes and macrophages in the presence of the selective alpha(1)-AR agonist (R)-(-)-phenylephrine hydrochloride (PE).	Phenylephrine	154-189	interleukin 1 beta	Homo sapiens	0-8
21571945-5	2011	IL-1beta production in response to LPS was synergistically higher for both monocytes and macrophages in the presence of the selective alpha(1)-AR agonist (R)-(-)-phenylephrine hydrochloride (PE).	Phenylephrine	191-193	interleukin 1 beta	Homo sapiens	0-8
21511336-3	2011	Thalidomide also promoted a slight increase in IL-6, IL-1beta and TNF-alpha expression in the stromal layers.	Thalidomide	0-11	interleukin 1 beta	Homo sapiens	53-61
21659536-0	2011	Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages.	Dipeptides	75-84	interleukin 1 beta	Homo sapiens	46-63
21659536-2	2011	Stimulation of primary monocyte-derived macrophages by muramyl dipeptide (MDP), a component of bacterial peptidoglycan and specific Nod2 ligand, produces cytokines, including IL-1beta.	Acetylmuramyl-Alanyl-Isoglutamine	55-72	interleukin 1 beta	Homo sapiens	175-183
21659536-2	2011	Stimulation of primary monocyte-derived macrophages by muramyl dipeptide (MDP), a component of bacterial peptidoglycan and specific Nod2 ligand, produces cytokines, including IL-1beta.	Acetylmuramyl-Alanyl-Isoglutamine	74-77	interleukin 1 beta	Homo sapiens	175-183
21696706-8	2011	Post-HI ibuprofen treatment significantly attenuated the P3 HI-induced increases in COX-2 protein expression as well as interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) levels in the brain.	Ibuprofen	8-17	interleukin 1 beta	Homo sapiens	120-137
21696706-8	2011	Post-HI ibuprofen treatment significantly attenuated the P3 HI-induced increases in COX-2 protein expression as well as interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) levels in the brain.	Ibuprofen	8-17	interleukin 1 beta	Homo sapiens	139-147
21640152-13	2011	In the in vitro model, IFN-alpha, IL-1beta, IL-6, IL-10, IP-10 and MIP-1alpha levels were significantly higher when measured at 6 and 24 h in cultures stimulated with Fluvax( ) compared with alternative 2010 TIV preparations.	fluvax	167-173	interleukin 1 beta	Homo sapiens	34-42
21646474-3	2011	Optimal doxorubicin treatment outcome also requires both interleukin (IL)-1beta and IL-17 cytokines, as blockade of IL-1beta/IL-1R or IL-17A/IL-17Ralpha signaling abrogated the therapeutic effect.	Doxorubicin	8-19	interleukin 1 beta	Homo sapiens	57-79
21646474-3	2011	Optimal doxorubicin treatment outcome also requires both interleukin (IL)-1beta and IL-17 cytokines, as blockade of IL-1beta/IL-1R or IL-17A/IL-17Ralpha signaling abrogated the therapeutic effect.	Doxorubicin	8-19	interleukin 1 beta	Homo sapiens	116-124
20599489-2	2011	MATERIALS AND METHODS: Primary human chondrocytes (PHC) were stimulated with IL-1beta or lipopolysaccharide (LPS) to induce the enhanced release of prostaglandin E(2) (PGE(2)), metalloproteinase (MMP-3 and -13), and cyclooxygenase-2 (COX-2) protein expression.	Prostaglandins E	168-171	interleukin 1 beta	Homo sapiens	77-85
21752263-11	2011	Following FcgammaR stimulation, PCI-32765 inhibited TNFalpha, IL-1beta and IL-6 production in primary monocytes (IC(50) = 2.6, 0.5, 3.9 nM, respectively).	ibrutinib	32-41	interleukin 1 beta	Homo sapiens	62-70
21536288-9	2011	Moreover, we found that tumor necrosis factor-alpha (TNF-alpha, 30 ng/mL) and interleukin-1beta (IL-1beta, 1 ng/mL) both induced time-dependent increase of MCP-3 production by CASMCs, which was reduced by the anti-MCP-3 antibody (20 ng/mL), suggesting that the mitogenic effect of these stimuli is due, at least in part, to MCP-3.	casmcs	176-182	interleukin 1 beta	Homo sapiens	78-95
21657246-10	2011	Of particular importance is that the genistein-modified blend membranes (PA:PVP/G) showed greater suppression of the concentrations of all three cytokines (TNF-alpha, IL-1beta, and IL-6) in comparison with those of the PA/G membranes, signifying the role of PVP in the enhanced anti-inflammatory properties of these genistein-modified membranes.	Genistein	37-46	interleukin 1 beta	Homo sapiens	167-175
20870897-3	2011	Troglitazone dose-dependently reduced the IL-1beta-induced release of IL-6 and vascular endothelial growth factor, the TNF-alpha-induced release of eotaxin and regulated on activation, normal T expressed and secreted (RANTES), and the IL-4-induced release of eotaxin.	Troglitazone	0-12	interleukin 1 beta	Homo sapiens	42-50
21400477-5	2011	Procatabolic responses to IL-1beta and TNFalpha, such as release of glycosaminoglycan, nitric oxide, and matrix metalloproteinases 3 and 13 were determined by dimethylmethylene blue assay, Griess reaction, and Western blotting, respectively, in cartilage explants and chondrocytes with and without knockdown of AMPKalpha by small interfering RNA.	Glycosaminoglycans	68-85	interleukin 1 beta	Homo sapiens	26-34
21400477-5	2011	Procatabolic responses to IL-1beta and TNFalpha, such as release of glycosaminoglycan, nitric oxide, and matrix metalloproteinases 3 and 13 were determined by dimethylmethylene blue assay, Griess reaction, and Western blotting, respectively, in cartilage explants and chondrocytes with and without knockdown of AMPKalpha by small interfering RNA.	Nitric Oxide	87-99	interleukin 1 beta	Homo sapiens	26-34
21400477-5	2011	Procatabolic responses to IL-1beta and TNFalpha, such as release of glycosaminoglycan, nitric oxide, and matrix metalloproteinases 3 and 13 were determined by dimethylmethylene blue assay, Griess reaction, and Western blotting, respectively, in cartilage explants and chondrocytes with and without knockdown of AMPKalpha by small interfering RNA.	dimethylmethylene blue	159-181	interleukin 1 beta	Homo sapiens	26-34
21726461-0	2011	Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults.	Hydrocortisone	14-22	interleukin 1 beta	Homo sapiens	77-94
21726461-0	2011	Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults.	Dexamethasone	40-43	interleukin 1 beta	Homo sapiens	77-94
21536288-9	2011	Moreover, we found that tumor necrosis factor-alpha (TNF-alpha, 30 ng/mL) and interleukin-1beta (IL-1beta, 1 ng/mL) both induced time-dependent increase of MCP-3 production by CASMCs, which was reduced by the anti-MCP-3 antibody (20 ng/mL), suggesting that the mitogenic effect of these stimuli is due, at least in part, to MCP-3.	casmcs	176-182	interleukin 1 beta	Homo sapiens	97-105
21397936-7	2011	RESULTS: Compared with NM from control subjects, PGE(2) concentrations were significantly lower in IL-1beta-stimulated fibroblasts from patients with NPs who were tolerant to aspirin and even lower in polyps from patients with AIA.	Dinoprostone	49-55	interleukin 1 beta	Homo sapiens	99-107
21424515-7	2011	RESULTS: NAC inhibits the inflammatory cytokines TNFalpha, IL-1beta and IL-6 in LPS-activated macrophages under mild oxidative conditions.	Acetylcysteine	9-12	interleukin 1 beta	Homo sapiens	59-67
21540068-8	2011	Mechanistic studies revealed that IFN-gamma production in response to MbetaCD plus IL-2 was IL-12 independent but depended on endogenous IL-18 and IL-1beta, and CD56(+)CD14(+) dendritic cell-like cells and B cells might mediate the ability of MbetaCD to activate NK cells.	methyl-beta-cyclodextrin	70-77	interleukin 1 beta	Homo sapiens	147-155
21397936-7	2011	RESULTS: Compared with NM from control subjects, PGE(2) concentrations were significantly lower in IL-1beta-stimulated fibroblasts from patients with NPs who were tolerant to aspirin and even lower in polyps from patients with AIA.	Aspirin	175-182	interleukin 1 beta	Homo sapiens	99-107
21397936-8	2011	Similarly, IL-1beta exposure induced the expression of COX-1 and COX-2 in fibroblasts from NM of control subjects, had only moderate effects on fibroblasts from NPs of aspirin-tolerant nonasthmatic patients, and almost no effect on fibroblasts from NPs of patients with AIA.	Aspirin	168-175	interleukin 1 beta	Homo sapiens	11-19
21508145-8	2011	Levothyroxine reduced monocyte release of TNF-alpha, IL-1beta, IL-6, and monocyte chemoattractant protein-1, whereas selenomethionine inhibited lymphocyte release of IL-2, interferon-gamma, and TNF-alpha, which was accompanied by a reduction in plasma CRP levels.	Thyroxine	0-13	interleukin 1 beta	Homo sapiens	53-61
20975573-0	2011	Interleukin 1 beta (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis.	Steroids	135-142	interleukin 1 beta	Homo sapiens	0-18
20975573-0	2011	Interleukin 1 beta (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis.	Steroids	135-142	interleukin 1 beta	Homo sapiens	20-25
20975573-0	2011	Interleukin 1 beta (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis.	Steroids	135-142	interleukin 1 beta	Homo sapiens	20-24
20975573-6	2011	In the subgroup analysis, we found a significant association between the RN6/2 GG (rs315951) and IL-1B-511 CC (rs16944) genotypes and the presence of steroid-dependence in UC patients (pC=00001, OR=15.6 and pC=0.008, OR=4.09, respectively).	Steroids	150-157	interleukin 1 beta	Homo sapiens	97-102
20975573-9	2011	CONCLUSIONS: IL-1 RN and IL-1B polymorphisms were associated with the genetic susceptibility to develop UC and might be associated with the presence of steroid-dependence in UC patients.	Steroids	152-159	interleukin 1 beta	Homo sapiens	25-30
21501605-6	2011	Forsythiaside also significantly decreased the number of ionized calcium-binding adaptor molecule-1-detected activated microglia and glial fibrillary acidic protein-detected astrocytes, both of which were increased after ischemic insults, and decreased interleukin-1beta and tumor necrosis factor-alpha expression levels, which were also increased after the insults (P&lt;0.05).	forsythiaside	0-13	interleukin 1 beta	Homo sapiens	253-302
21430599-1	2011	The shortage of geranylgeranyl-pyrophosphate (GGPP) was associated to an increased IL-1beta release in the autoinflammatory syndrome mevalonate kinase deficiency (MKD), a rare inherited disease that has no specific therapy.	geranylgeranyl pyrophosphate	16-44	interleukin 1 beta	Homo sapiens	83-91
21430599-1	2011	The shortage of geranylgeranyl-pyrophosphate (GGPP) was associated to an increased IL-1beta release in the autoinflammatory syndrome mevalonate kinase deficiency (MKD), a rare inherited disease that has no specific therapy.	geranylgeranyl pyrophosphate	46-50	interleukin 1 beta	Homo sapiens	83-91
22152249-9	2011	Glycogen synthase kinase-3 beta inhibitor SB216763-pretreatment ameliorated the liver damages significantly as compared to the controls (sALT: 2046+/-513 U/L vs 5809+/-1689 U/L, P = 0.0153), and suppressed the gene expressions of IL-12, TNFa, IL-1b and IL-6.	SB 216763	42-50	interleukin 1 beta	Homo sapiens	243-248
21402594-6	2011	Ultimately, anti-cmvIL-10 antibodies blocked the inhibitory effect of cmvIL-10 on lipopolysaccharide-induced tumour necrosis factor alpha and IL-1beta from blood mononuclear cells.	cmvil-10	17-25	interleukin 1 beta	Homo sapiens	142-150
21402594-6	2011	Ultimately, anti-cmvIL-10 antibodies blocked the inhibitory effect of cmvIL-10 on lipopolysaccharide-induced tumour necrosis factor alpha and IL-1beta from blood mononuclear cells.	cmvil-10	70-78	interleukin 1 beta	Homo sapiens	142-150
21447646-4	2011	In primary human macrophages from healthy volunteers, Ado inhibited sFlt-1 expression induced by LPS (-43%, P=0.006), HS, and IL-1beta but not hypoxia.	beta-apocarotenoid-14',13'-dioxygenase	54-57	interleukin 1 beta	Homo sapiens	126-134
21501605-8	2011	These results suggest that forsythiaside exhibits neuroprotective properties, which are, in part, mediated by its anti-inflammatory activities supported by forsythiaside-induced reductions of activated glial cells and expression levels of interleukin-1beta and tumor necrosis factor-alpha.	forsythiaside	27-40	interleukin 1 beta	Homo sapiens	239-288
21501605-8	2011	These results suggest that forsythiaside exhibits neuroprotective properties, which are, in part, mediated by its anti-inflammatory activities supported by forsythiaside-induced reductions of activated glial cells and expression levels of interleukin-1beta and tumor necrosis factor-alpha.	forsythiaside	156-169	interleukin 1 beta	Homo sapiens	239-288
21352397-0	2011	Uric acid induces trophoblast IL-1beta production via the inflammasome: implications for the pathogenesis of preeclampsia.	Uric Acid	0-9	interleukin 1 beta	Homo sapiens	30-38
21621513-6	2011	Furthermore, pretreatment with casuarinin decreased TNF-alpha-induced pro-inflammatory mediators, such as IL-1beta, IL-6, IL-8, and MCP-1.	casuarinin	31-41	interleukin 1 beta	Homo sapiens	106-114
21682898-0	2011	Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes.	epigallocatechin gallate	0-26	interleukin 1 beta	Homo sapiens	49-66
21682898-3	2011	The objective of this study was to evaluate the global effect of EGCG on IL-1beta-induced expression of proteins associated with OA pathogenesis in human chondrocytes.	epigallocatechin gallate	65-69	interleukin 1 beta	Homo sapiens	73-81
21682898-6	2011	Effect of EGCG on IL-1beta-induced expression of 18 selected genes was verified by Real time-PCR and effect on IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha) production was determined using specific ELISAs.	epigallocatechin gallate	10-14	interleukin 1 beta	Homo sapiens	18-26
21682898-7	2011	Western immunoblotting was used to analyze the effect of EGCG on the interleukin-1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF-6) proteins in IL-1beta-stimulated chondrocytes.	epigallocatechin gallate	57-61	interleukin 1 beta	Homo sapiens	179-187
21682898-12	2011	Expression of all 29 proteins up-regulated by IL-1beta was found to be suppressed by EGCG.	epigallocatechin gallate	85-89	interleukin 1 beta	Homo sapiens	46-54
21555117-6	2011	Our results showed that rifampicin inhibited the LPS-stimulated expression of inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, and interleukin-1beta, as well as the production of nitric oxide and prostaglandin E2.	Rifampin	24-34	interleukin 1 beta	Homo sapiens	162-179
21352397-3	2011	Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing.	Uric Acid	0-9	interleukin 1 beta	Homo sapiens	117-125
21352397-3	2011	Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing.	Uric Acid	14-30	interleukin 1 beta	Homo sapiens	117-125
21352397-3	2011	Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing.	Uric Acid	32-35	interleukin 1 beta	Homo sapiens	117-125
21352397-11	2011	CONCLUSION: These findings demonstrate that uric acid activates the inflammasome in the trophoblast, leading to IL-1beta production.	Uric Acid	44-53	interleukin 1 beta	Homo sapiens	112-120
21256955-4	2011	Drugs of abuse such as opioids, psychostimulants, and alcohol induce neuroinflammatory mediators such as pro-inflammatory cytokines (e.g. interleukin (IL)-1beta), which modulate drug reward, dependence, and tolerance as well as analgesic properties.	Alcohols	54-61	interleukin 1 beta	Homo sapiens	138-160
21421269-5	2011	Beta-TCP 1 mum did not induce any cytokine after 6 h but slightly increases TNF-alpha, IL-1beta and IL-8 release after 18 h. Larger particles (32 and 40 mum) consistently caused higher levels of cytokine release by increasing the fraction of cytokine producing monocytes.	beta-tricalcium phosphate	0-8	interleukin 1 beta	Homo sapiens	87-95
20887233-0	2011	Cyclic mechanical stretch downregulates IL-1beta-induced COX-2 expression and PGE(2) production in rheumatoid arthritis fibroblast-like synoviocytes.	Dinoprostone	78-84	interleukin 1 beta	Homo sapiens	40-48
20956097-5	2011	Further we analyzed the effect of sulforaphane on the expression of Bcl-2, COX-2 and IL-1beta by RT-PCR on HeLa cells.	sulforaphane	34-46	interleukin 1 beta	Homo sapiens	85-93
20956097-8	2011	Also, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2 and IL-1beta upon treatment with sulforaphane.	sulforaphane	163-175	interleukin 1 beta	Homo sapiens	134-142
21421749-5	2011	Inhibition of GSK-3 by the selective inhibitor SB216763 or CHIR/CT99021 attenuated the cytokine and growth factor release induced by CSE and/or IL-1beta, without affecting the basal release.	SB 216763	47-55	interleukin 1 beta	Homo sapiens	144-152
21421749-8	2011	However, induction of NF-kappaB-dependent transcriptional activity by IL-1beta and CSE was largely reduced upon GSK-3 inhibition by SB216763.	SB 216763	132-140	interleukin 1 beta	Homo sapiens	70-78
21458436-4	2011	A correlation between AOPP/Thiols and IL-1beta in AMI was found.	aopp/thiols	22-33	interleukin 1 beta	Homo sapiens	38-46
20887233-8	2011	It also downregulated the IL-1beta-induced production of PGE(2).	Prostaglandins E	57-60	interleukin 1 beta	Homo sapiens	26-34
21419123-6	2011	Co-incubation with TNF-alpha+IL-1beta intensified the activation of NO/NOS, JNK1/2, caspase-8, caspase-9 and caspase-3 by UCB.	ucb	122-125	interleukin 1 beta	Homo sapiens	29-37
21369818-0	2011	Fenofibric acid prevents retinal pigment epithelium disruption induced by interleukin-1beta by suppressing AMP-activated protein kinase (AMPK) activation.	fenofibric acid	0-15	interleukin 1 beta	Homo sapiens	74-91
21369818-8	2011	RESULTS: Treatment of ARPE-19 cells with fenofibric acid significantly reduced the increment of permeability and the breakdown of the ARPE-19 cell monolayer induced by D-glucose, 25 mmol/l, and IL-1beta, 10 ng/ml, in a dose-dependent manner.	fenofibric acid	41-56	interleukin 1 beta	Homo sapiens	194-202
21369818-10	2011	Fenofibric acid prevented the activation of AMPK induced by IL-1beta and the hyperpermeability induced by IL-1beta was blocked by silencing AMPK.	fenofibric acid	0-15	interleukin 1 beta	Homo sapiens	60-68
21369818-10	2011	Fenofibric acid prevented the activation of AMPK induced by IL-1beta and the hyperpermeability induced by IL-1beta was blocked by silencing AMPK.	fenofibric acid	0-15	interleukin 1 beta	Homo sapiens	106-114
21369818-11	2011	CONCLUSIONS/INTERPRETATION: Disruption of RPE induced by IL-1beta is prevented by fenofibric acid through its ability to suppress AMPK activation.	fenofibric acid	82-97	interleukin 1 beta	Homo sapiens	57-65
20626232-8	2011	In addition, MW attenuated the PMACI-stimulated expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-6, and IL-8 in human mast cells.	pmaci	31-36	interleukin 1 beta	Homo sapiens	126-143
21560112-7	2011	The proinflammatory cytokines IL1-beta and TNF-alpha significantly increased the expression of CTGF (p&lt;0.05) by 65.1% and 101.3%, respectively, and the expression and secretion of OGP by 62.3-165.8% (p&lt;0.05).	octyl-beta-D-glucoside	183-186	interleukin 1 beta	Homo sapiens	30-38
21560112-8	2011	This interleukin 1-beta mediated increase in CTGF- and OPG expression and secretion was ameliorated by troglitazone.	Troglitazone	103-115	interleukin 1 beta	Homo sapiens	5-23
21069571-9	2011	Dexamethasone attenuated LPS-induced IL-1 beta (IC(50) = 70 nM), IL-6 (IC(50) = 58 nM) and TNF-alpha (IC(50) = 44 nM) release, whereas celecoxib, a specific COX-2 inhibitor showed marked reduction in LPS-induced PGE(2) (IC(50) = 23 nM) production.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	37-46
20626232-8	2011	In addition, MW attenuated the PMACI-stimulated expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-6, and IL-8 in human mast cells.	pmaci	31-36	interleukin 1 beta	Homo sapiens	145-153
21624620-10	2011	Claudin-1 upregulation by IL-1beta or TNF-alpha was suppressed by dexamethasone but not by rapamycin, FK506, or salbutamol.	Dexamethasone	66-79	interleukin 1 beta	Homo sapiens	26-34
21272678-12	2011	In human mononuclear leukocyte, isoforskolin (50, 100, and 200 muM) and dexamethasone (10 muM) pre-incubation lowered lipopolysaccharide (2 mug/mL) induced secretion of the cytokine TNF-alpha, and interleukins (IL)-1beta, IL-6, and IL-8.	Dexamethasone	72-85	interleukin 1 beta	Homo sapiens	197-220
21448594-0	2011	Interleukin-1beta inhibits voltage-gated sodium currents in a time- and dose-dependent manner in cortical neurons.	Sodium	41-47	interleukin 1 beta	Homo sapiens	0-17
21557245-13	2011	In our organ culture model, IL-1beta stimulated PGE2 secretion in a dose-dependent manner.	Dinoprostone	48-52	interleukin 1 beta	Homo sapiens	28-36
21278069-10	2011	We further showed that inhibition of ERM phosphorylation by siRNA-mediated ERM knockdown suppressed TNF-alpha- or IL-1beta-induced BrdU incorporation and PCNA expression in RA FLS.	Bromodeoxyuridine	131-135	interleukin 1 beta	Homo sapiens	114-122
21428299-3	2011	Sesamol significantly attenuated TNF-alpha- and IL-1beta-induced gelatinolysis and expression of MMP-9 in a concentration-dependent manner in SW1353 cells.	sesamol	0-7	interleukin 1 beta	Homo sapiens	48-56
21275990-7	2011	Conditioned medium from UCB-challenged neurons, although down-regulating tumor necrosis factor-alpha and interleukin-1beta promoted the release of interleukin-6 and nitric oxide, the activation of matrix metalloproteinase-9, and cell death, as compared with UCB-direct effects on microglia.	Nitric Oxide	165-177	interleukin 1 beta	Homo sapiens	105-122
21484156-3	2011	In this study, we investigated whether curcumin and resveratrol can synergistically inhibit the catabolic effects of IL-1beta, specifically the inhibition of the MAPK and subsequent apoptosis in human articular chondrocytes.	Curcumin	39-47	interleukin 1 beta	Homo sapiens	117-125
21484156-3	2011	In this study, we investigated whether curcumin and resveratrol can synergistically inhibit the catabolic effects of IL-1beta, specifically the inhibition of the MAPK and subsequent apoptosis in human articular chondrocytes.	Resveratrol	52-63	interleukin 1 beta	Homo sapiens	117-125
21484156-7	2011	Interestingly, U0126 induced apoptosis and blocked the above-mentioned proteins in a similar way to IL-1beta.	U 0126	15-20	interleukin 1 beta	Homo sapiens	100-108
21484156-8	2011	Furthermore, curcumin and resveratrol inhibited IL-1beta- or U0126-induced apoptosis and downregulation of beta1-integrins and Erk1/2 in human articular chondrocytes.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	48-56
21484156-8	2011	Furthermore, curcumin and resveratrol inhibited IL-1beta- or U0126-induced apoptosis and downregulation of beta1-integrins and Erk1/2 in human articular chondrocytes.	Resveratrol	26-37	interleukin 1 beta	Homo sapiens	48-56
21605007-4	2011	RESULTS: At baseline, the purines AMP and hypoxanthine correlated with multiple inflammatory markers including neutrophil counts and the cytokines interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), and IL-1beta (r ranged from 0.41 to 0.66, all P &lt; 0.05).	Hypoxanthine	42-54	interleukin 1 beta	Homo sapiens	218-226
21605009-6	2011	We also observed that cadmium induced elevated expression of epidermal growth factor receptor (EGFR) along with different proinflammatory cytokines like interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Cadmium	22-29	interleukin 1 beta	Homo sapiens	153-171
21605009-6	2011	We also observed that cadmium induced elevated expression of epidermal growth factor receptor (EGFR) along with different proinflammatory cytokines like interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Cadmium	22-29	interleukin 1 beta	Homo sapiens	173-181
21480939-7	2011	IL-1beta and MMP-8 levels decreased significantly from baseline (p&lt;0.04) in the SRP group only.	L-seryl-AMP	83-86	interleukin 1 beta	Homo sapiens	0-8
21540455-5	2011	According to the first model, MLA fails to induce maturation of the proinflammatory cytokine IL-1beta because it fails to activate caspase-1, which is required for the conversion of pro-IL-1beta into its bioactive form.	monophosphoryl lipid A	30-33	interleukin 1 beta	Homo sapiens	182-194
21540455-9	2011	In addition, we elucidated the contributions of MyD88 and TRIF to priming of the NLRP3 inflammasome and demonstrated that TRIF-biased TLR4 activation by MLA was responsible for the defective production of mature IL-1beta.	monophosphoryl lipid A	153-156	interleukin 1 beta	Homo sapiens	212-220
21310944-13	2011	Together, these results indicate that macrophage-mediated induction of COX-2 in breast cancer cells is a consequence of IL-1beta-mediated stimulation of ROS Src MAPK AP-1 signaling.	Reactive Oxygen Species	153-156	interleukin 1 beta	Homo sapiens	120-128
21605007-4	2011	RESULTS: At baseline, the purines AMP and hypoxanthine correlated with multiple inflammatory markers including neutrophil counts and the cytokines interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), and IL-1beta (r ranged from 0.41 to 0.66, all P &lt; 0.05).	Purines	26-33	interleukin 1 beta	Homo sapiens	218-226
21605007-4	2011	RESULTS: At baseline, the purines AMP and hypoxanthine correlated with multiple inflammatory markers including neutrophil counts and the cytokines interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), and IL-1beta (r ranged from 0.41 to 0.66, all P &lt; 0.05).	Adenosine Monophosphate	34-37	interleukin 1 beta	Homo sapiens	218-226
21275990-7	2011	Conditioned medium from UCB-challenged neurons, although down-regulating tumor necrosis factor-alpha and interleukin-1beta promoted the release of interleukin-6 and nitric oxide, the activation of matrix metalloproteinase-9, and cell death, as compared with UCB-direct effects on microglia.	ucb	24-27	interleukin 1 beta	Homo sapiens	105-122
21308147-8	2011	Gene network analysis of the 1,320 genes suggested that IL1B, S100A8, S100A9 and EGFR were important mediators of MIBC progression.	4-METHYL-2-PENTANOL	114-118	interleukin 1 beta	Homo sapiens	56-60
21437951-3	2011	This study aimed to determine the expression of ADAMTS-5 in human herniated intervertebral disc (IVD) tissues and to investigate whether interleukin-1beta (IL-1beta)-induced expression of ADAMTS-5 is mediated by nitric oxide (NO).	Nitric Oxide	212-224	interleukin 1 beta	Homo sapiens	137-154
21437951-3	2011	This study aimed to determine the expression of ADAMTS-5 in human herniated intervertebral disc (IVD) tissues and to investigate whether interleukin-1beta (IL-1beta)-induced expression of ADAMTS-5 is mediated by nitric oxide (NO).	Nitric Oxide	212-224	interleukin 1 beta	Homo sapiens	156-164
21277871-6	2011	IL-1beta induced PGE(2) release and COX-2 and mPGES-1 expression in terms of mRNA and protein, determined by real-time PCR and immunoblotting, respectively.	Prostaglandins E	17-20	interleukin 1 beta	Homo sapiens	0-8
21437951-8	2011	Aminoguanidine significantly reversed the changes in alginate beads induced by IL-1beta treatment.	pimagedine	0-14	interleukin 1 beta	Homo sapiens	79-87
21437951-8	2011	Aminoguanidine significantly reversed the changes in alginate beads induced by IL-1beta treatment.	Alginates	53-61	interleukin 1 beta	Homo sapiens	79-87
21315154-4	2011	Three of the four tested macrolides, azithromycin, clarithromycin and roxithromycin, exhibited pronounced, concentration-related reduction of IL-1beta, IL-6, IL-10, TNF-alpha, CCL3, CCL5, CCL20, CCL22, CXCL1, CXCL5, and G-CSF release.	Azithromycin	37-49	interleukin 1 beta	Homo sapiens	142-150
21478880-2	2011	Interleukin (IL)-1beta plays a role in insulin resistance, yet how IL-1beta is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear.	Fatty Acids	94-105	interleukin 1 beta	Homo sapiens	67-75
21478880-3	2011	We show that the saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1beta and IL-18 production.	saturated fatty acid palmitate	17-47	interleukin 1 beta	Homo sapiens	150-158
21866484-9	2011	In epilepsy patients studies (including ex vivo) show elevated levels of IL-1 beta, IL-2, IL-5, IL-6 or TNF- alpha after carbamazepine, valproic acid and phenytoin.	Carbamazepine	121-134	interleukin 1 beta	Homo sapiens	73-82
21866484-9	2011	In epilepsy patients studies (including ex vivo) show elevated levels of IL-1 beta, IL-2, IL-5, IL-6 or TNF- alpha after carbamazepine, valproic acid and phenytoin.	Valproic Acid	136-149	interleukin 1 beta	Homo sapiens	73-82
21866484-9	2011	In epilepsy patients studies (including ex vivo) show elevated levels of IL-1 beta, IL-2, IL-5, IL-6 or TNF- alpha after carbamazepine, valproic acid and phenytoin.	Phenytoin	154-163	interleukin 1 beta	Homo sapiens	73-82
21315154-7	2011	Qualitatively and quantitatively, macrolides exerted distinctive and, compared to other tested classes of compounds, more pronounced immunomodulatory effects, particularly in terms of chemokine (CCL3, CCL5, CCL20, CCL22, and CXCL5), IL-1beta, G-CSF and PAI-1 release.	Macrolides	34-44	interleukin 1 beta	Homo sapiens	233-241
21291939-5	2011	Proinflammatory cytokine secretion (IL-1beta and IL-6) by the epithelial cells was also regulated by KSL-W in a manner similar to that of antifungal molecule amphotericin B.	KSL-W	101-106	interleukin 1 beta	Homo sapiens	36-44
21315154-4	2011	Three of the four tested macrolides, azithromycin, clarithromycin and roxithromycin, exhibited pronounced, concentration-related reduction of IL-1beta, IL-6, IL-10, TNF-alpha, CCL3, CCL5, CCL20, CCL22, CXCL1, CXCL5, and G-CSF release.	Clarithromycin	51-65	interleukin 1 beta	Homo sapiens	142-150
21315154-4	2011	Three of the four tested macrolides, azithromycin, clarithromycin and roxithromycin, exhibited pronounced, concentration-related reduction of IL-1beta, IL-6, IL-10, TNF-alpha, CCL3, CCL5, CCL20, CCL22, CXCL1, CXCL5, and G-CSF release.	Roxithromycin	70-83	interleukin 1 beta	Homo sapiens	142-150
21486440-0	2011	Inflammatory mediators in breast cancer: coordinated expression of TNFalpha &amp; IL-1beta with CCL2 &amp; CCL5 and effects on epithelial-to-mesenchymal transition.	Adenosine Monophosphate	77-80	interleukin 1 beta	Homo sapiens	82-90
21237205-4	2011	Furthermore, when stimulated with flagellin, ATRA-induced THP-1 cells expressed multiple cytokines, including TNF-alpha, IL-1beta, and IL-12p40, and several co-stimulatory molecules, such as CD40, CD80, CD86, and MHC class I and II.	Tretinoin	45-49	interleukin 1 beta	Homo sapiens	121-129
21516291-6	2011	By the suppression of IL-1 beta production in the activated human monocytes, adenosine can decrease the release of AA causing a diminished phosphorylation of both PKC isoenzymes.	Adenosine	77-86	interleukin 1 beta	Homo sapiens	22-31
21486440-0	2011	Inflammatory mediators in breast cancer: coordinated expression of TNFalpha &amp; IL-1beta with CCL2 &amp; CCL5 and effects on epithelial-to-mesenchymal transition.	Adenosine Monophosphate	102-105	interleukin 1 beta	Homo sapiens	82-90
21486440-6	2011	Significant associations were found between CCL2 &amp; CCL5 and TNFalpha &amp; IL-1beta in the tumor cells in DCIS and IDC-no-relapse patients.	Adenosine Monophosphate	50-53	interleukin 1 beta	Homo sapiens	79-87
21486440-7	2011	In the IDC-with-relapse group, the expression of CCL2 &amp; CCL5 was accompanied by further elevated incidence of TNFalpha &amp; IL-1beta expression.	Adenosine Monophosphate	55-58	interleukin 1 beta	Homo sapiens	129-137
21486440-7	2011	In the IDC-with-relapse group, the expression of CCL2 &amp; CCL5 was accompanied by further elevated incidence of TNFalpha &amp; IL-1beta expression.	Adenosine Monophosphate	124-127	interleukin 1 beta	Homo sapiens	129-137
21435451-6	2011	In response to tumor necrosis factor (TNF-alpha), IL-1beta, and cocultured lymphocytes, however, mPGES-1 and COX-2 protein expression increased in fibroblasts and smooth muscle cells, accompanied by increased PGE(2), whereas mPGES-2 and cPGES were unaffected.	Prostaglandins E	98-101	interleukin 1 beta	Homo sapiens	50-58
21143255-12	2011	CONCLUSIONS: Alcohol interferes with the kinetics of Foxp3, RORgammat, and T-bet gene expression and the production of TNF-alpha and IL-1ss and influences the balance of Treg/Th17 cells following LPS exposure.	Alcohols	13-20	interleukin 1 beta	Homo sapiens	133-137
21276586-5	2011	Simvastatin and fenofibrate decreased monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1 and lymphocyte release of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha, which was accompanied by a decrease in plasma C-reactive protein levels.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	87-104
21276586-5	2011	Simvastatin and fenofibrate decreased monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1 and lymphocyte release of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha, which was accompanied by a decrease in plasma C-reactive protein levels.	Fenofibrate	16-27	interleukin 1 beta	Homo sapiens	87-104
21166654-2	2011	PI3K inhibitor, LY294002 significantly reduced IL-1beta-induced IL-6 production in A549 cells but not in RASF, indicating that IL-1beta-induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	interleukin 1 beta	Homo sapiens	47-55
21166654-2	2011	PI3K inhibitor, LY294002 significantly reduced IL-1beta-induced IL-6 production in A549 cells but not in RASF, indicating that IL-1beta-induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	interleukin 1 beta	Homo sapiens	127-135
21220057-2	2011	The present study showed that sildenafil, a PDE5 inhibitor, significantly suppressed NO, interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) production induced by LPS in microglial cells through decreasing the protein and/or mRNA expressions of inducible NO synthase (iNOS), IL-1beta and TNF-alpha in a concentration-dependent manner.	Sildenafil Citrate	30-40	interleukin 1 beta	Homo sapiens	89-106
21234729-6	2011	Uric acid crystals also have been shown to trigger interleukin-1beta-mediated inflammation via activation of the NOD-like receptor protein (NLRP)3 inflammasome, a multimolecular complex whose activation appears to be central to many pathological inflammatory conditions.	Uric Acid	0-9	interleukin 1 beta	Homo sapiens	51-68
21220057-2	2011	The present study showed that sildenafil, a PDE5 inhibitor, significantly suppressed NO, interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) production induced by LPS in microglial cells through decreasing the protein and/or mRNA expressions of inducible NO synthase (iNOS), IL-1beta and TNF-alpha in a concentration-dependent manner.	Sildenafil Citrate	30-40	interleukin 1 beta	Homo sapiens	108-116
21220057-2	2011	The present study showed that sildenafil, a PDE5 inhibitor, significantly suppressed NO, interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) production induced by LPS in microglial cells through decreasing the protein and/or mRNA expressions of inducible NO synthase (iNOS), IL-1beta and TNF-alpha in a concentration-dependent manner.	Sildenafil Citrate	30-40	interleukin 1 beta	Homo sapiens	296-304
21262970-10	2011	In accordance with the observation that P2X7 controls the cytokine release from LPS-primed macrophages, we found that clemastine augmented the IL-1beta release from LPS-primed human macrophages.	Clemastine	118-128	interleukin 1 beta	Homo sapiens	143-151
21294228-3	2011	Examination of these (R)- and (S)-Bgl 101.10 analogs for their potential to inhibit IL-1beta-induced thymocyte cell proliferation using a novel fluorescence assay revealed that certain analogs exhibited retained and improved potency relative to the parent peptide 101.10.	Ranolazine	21-29	interleukin 1 beta	Homo sapiens	84-92
21296955-3	2011	In human vascular smooth muscle cells (VSMC), hypoxia and interleukin (IL)-1beta synergistically increased prostaglandin (PG)I2 but not PGE2 release, thereby increasing the PGI2/PGE2 ratio.	vsmc	39-43	interleukin 1 beta	Homo sapiens	58-80
21296955-3	2011	In human vascular smooth muscle cells (VSMC), hypoxia and interleukin (IL)-1beta synergistically increased prostaglandin (PG)I2 but not PGE2 release, thereby increasing the PGI2/PGE2 ratio.	Epoprostenol	107-127	interleukin 1 beta	Homo sapiens	58-80
21296955-3	2011	In human vascular smooth muscle cells (VSMC), hypoxia and interleukin (IL)-1beta synergistically increased prostaglandin (PG)I2 but not PGE2 release, thereby increasing the PGI2/PGE2 ratio.	Dinoprostone	136-140	interleukin 1 beta	Homo sapiens	58-80
21296955-3	2011	In human vascular smooth muscle cells (VSMC), hypoxia and interleukin (IL)-1beta synergistically increased prostaglandin (PG)I2 but not PGE2 release, thereby increasing the PGI2/PGE2 ratio.	Epoprostenol	173-177	interleukin 1 beta	Homo sapiens	58-80
21296955-3	2011	In human vascular smooth muscle cells (VSMC), hypoxia and interleukin (IL)-1beta synergistically increased prostaglandin (PG)I2 but not PGE2 release, thereby increasing the PGI2/PGE2 ratio.	Dinoprostone	178-182	interleukin 1 beta	Homo sapiens	58-80
21316309-0	2011	Metformin modulates IL-8, IL-1beta, ICAM and IGFBP-1 expression in human endometrial stromal cells.	Metformin	0-9	interleukin 1 beta	Homo sapiens	26-34
21316309-7	2011	The negative effect of insulin on IL-8 (4.8 fold) and IL-1beta (9.3 fold) gene expression was similarly found in cells incubated with metformin.	Metformin	134-143	interleukin 1 beta	Homo sapiens	54-62
21418620-9	2011	Plasma IL-6 and IL-1 beta were increased in ICM and decreased in NIDCM, vs controls, respectively.IL-9 levels inversely correlated, in ICM patients, with left ventricular ejection fraction (LVEF) while IL-5 plasma levels inversely correlated with disease duration, in NYHA III/IV ICM patients.This is the first time that both an increase of plasma IL-9, and a decrease of plasma IL-5, IL-7 and IFN-gamma have been reported in ICM as well as in NIDCM groups, vs controls.	nidcm	65-70	interleukin 1 beta	Homo sapiens	16-25
21239489-0	2011	Cortisol synthesis in epidermis is induced by IL-1 and tissue injury.	Hydrocortisone	0-8	interleukin 1 beta	Homo sapiens	46-50
21239489-7	2011	Conversely, inhibition of cortisol synthesis during wound healing increases IL-1beta production, suggesting that cortisol synthesis in epidermis may serve as a local negative feedback to proinflammatory cytokines.	Hydrocortisone	26-34	interleukin 1 beta	Homo sapiens	76-84
21239489-7	2011	Conversely, inhibition of cortisol synthesis during wound healing increases IL-1beta production, suggesting that cortisol synthesis in epidermis may serve as a local negative feedback to proinflammatory cytokines.	Hydrocortisone	113-121	interleukin 1 beta	Homo sapiens	76-84
21211511-9	2011	These results provide strong pharmacological and genetic evidence for the implication of H-Ras and NADPH oxidase-generated superoxide production in MMP-13 gene regulation by IL-1beta and TNF-alpha.	Superoxides	123-133	interleukin 1 beta	Homo sapiens	174-182
21245135-3	2011	After TLR4 signaling, SIRT1 rapidly accumulated at the promoters of TNF-alpha and IL-1beta, but not IkappaBalpha; SIRT1 promoter binding was dependent on its co-factor, NAD(+).	NAD	169-175	interleukin 1 beta	Homo sapiens	82-90
21388551-10	2011	Oxysterols can induce the production of inflammatory cytokines such as interleukin-8 and interleukin-1beta.	Oxysterols	0-10	interleukin 1 beta	Homo sapiens	89-106
21211511-3	2011	Manumycin A, an inhibitor of H-Ras farnesylation by farnesyltransferase, suppressed IL-1beta- and TNF-alpha-induced MMP-13 mRNA and protein expression.	manumycin	0-11	interleukin 1 beta	Homo sapiens	84-92
21217200-6	2011	IL-1beta secretion was also observed using calreticulin knock down or necrostatin treated autophagic MCF-7 cells and it required phagocytosis of the dying cells which led to ATP secretion from macrophages.	necrostatin-1	70-81	interleukin 1 beta	Homo sapiens	0-8
21385358-10	2011	Podoplanin was expressed in 50% of cultured primary FLSs, and the expression was increased by interleukin 1beta, tumour necrosis factor alpha and transforming growth factor beta receptor 1.	podoplanin	0-10	interleukin 1 beta	Homo sapiens	94-188
20160043-10	2011	Our findings suggest that CS amplifies the LPS-induced macrophages" secretion of IL-1beta and TNF-alpha through synergizing SP secretion, which activates NF-kappaB via binding with NK1R.	Cesium	26-28	interleukin 1 beta	Homo sapiens	81-89
21217200-6	2011	IL-1beta secretion was also observed using calreticulin knock down or necrostatin treated autophagic MCF-7 cells and it required phagocytosis of the dying cells which led to ATP secretion from macrophages.	Adenosine Triphosphate	174-177	interleukin 1 beta	Homo sapiens	0-8
21217200-8	2011	These data suggest that during phagocytosis of autophagic dying cells ATP, acting through its receptor, initiates K (+) efflux, inflammasome activation and secretion of IL-1beta, which initiates further pro-inflammatory events.	Adenosine Triphosphate	70-73	interleukin 1 beta	Homo sapiens	169-177
20926803-5	2011	We show that incubation of primary human amnion epithelial cells with IL1B results in a rapid, transient up-regulation of OXTR mRNA expression, which peaks in prelabor samples after 6 h. Incubation of prelabor amnion epithelial cells with OXT results in a marked increase of prostaglandin E(2) synthesis, and we demonstrate that OXT activates the extracellular signal-regulated protein kinase signal transduction pathway to stimulate up-regulation of cyclo-oxygenase 2 in human amnion epithelial cells.	Prostaglandins E	275-290	interleukin 1 beta	Homo sapiens	70-74
21040358-6	2011	Pre-treatment of human monocyte-derived and alveolar macrophages with the NOD2 ligand muramyl dipeptide enhanced production of TNF-alpha and IL-1beta in response to M.tb and BCG in a RIP2-dependent fashion.	Dipeptides	94-103	interleukin 1 beta	Homo sapiens	141-149
21216561-5	2011	The results showed that atorvastatin significantly decreased the expression of six cytokines (IL-6, IL-8, IL-1, PAI-1, TGF-beta1, TGF-beta2) and five chemokines (CCL2, CCL7, CCL13, CCL18, CXCL1).	Atorvastatin	24-36	interleukin 1 beta	Homo sapiens	106-110
21372033-7	2011	Saturated fatty acids, which have been linked to obesity-related inflammation, stimulated NF-kappaB activity in macrophages leading to increased levels of TNF-alpha, IL-1beta, and Cox-2, each of which contributed to the induction of aromatase in preadipocytes.	Fatty Acids	0-21	interleukin 1 beta	Homo sapiens	166-174
21289232-5	2011	Pioglitazone therapy in type 2 diabetes was associated with decreased expression of IL-1beta, IL-1Ra, and IL-10 in EAT; decreased IL-10 in SAT; and increased PPARgamma in SAT.	Pioglitazone	0-12	interleukin 1 beta	Homo sapiens	84-92
21130134-6	2011	In vitro, CCN expression is finely regulated by diverse inflammatory mediators including cytokines (TNFalpha, IL1beta, TGF-beta), small factors such as prostaglandins, nitric oxide, histamine and serotonin, and extracellular matrix enzymes.	acetonitrile	10-13	interleukin 1 beta	Homo sapiens	110-117
20851496-7	2011	We observed that monocytes stimulated to differentiate in the presence of NaB displayed colony formation and dendritic cell morphology, lost CD14 and showed decreased secretion of IL-1beta.	nab	74-77	interleukin 1 beta	Homo sapiens	180-188
21147091-4	2011	In this study, LPS treatment led to a marked upregulation of the levels of IL-1beta, IL-18, TNF-alpha, TGF-beta1, CCL2, CCL3, and CCL5 in HRMCs.	hrmcs	138-143	interleukin 1 beta	Homo sapiens	75-83
21147091-7	2011	Moreover, honokiol almost completely reversed IL-1beta, CCL3, and NO expression at 10 mumol/l, and IL-18, TNF-alpha, TGF-beta1, and COX-2 expression at 20 mumol/l.	honokiol	10-18	interleukin 1 beta	Homo sapiens	46-54
20971568-4	2011	The consumption of (-)-epigallocatechin 3-gallate (EGCG) has been studied extensively as a potential treatment for a variety of carcinogenic and degenerative diseases due to its ability to suppress a variety of inflammatory and angiogenic factors such as NF-kappaB, IL-1beta, COX2, VEGF, and matrix metalloproteinases.	epigallocatechin gallate	19-49	interleukin 1 beta	Homo sapiens	266-274
21329621-7	2011	In the third experiment, the effects of benzbromarone on IL1beta-induced CRP expression were determined in HuH7 cells.	Benzbromarone	40-53	interleukin 1 beta	Homo sapiens	57-64
21329621-10	2011	Furthermore, our in vitro findings demonstrated that benzbromarone down-regulated IL1beta-stimulated CRP gene expression.	Benzbromarone	53-66	interleukin 1 beta	Homo sapiens	82-89
21282043-9	2011	Consequently, quercetin suppressed UV irradiation-induced expression of inflammatory cytokines IL-1beta (~60%), IL-6 (~80%), IL-8 (~76%) and TNF-alpha (~69%).	Quercetin	14-23	interleukin 1 beta	Homo sapiens	95-103
21485100-7	2011	ROS stimulates alveolar macrophages and neutrophils to release inflammatory cytokines, such as TNF-alpha, IL-8, IFN-gamma, IL-6 and IL-1beta.	Reactive Oxygen Species	0-3	interleukin 1 beta	Homo sapiens	132-140
21106803-8	2011	Similarly, expression of interleukin-1beta, -6 and -8, which were markedly elevated in infected HBCAs, exhibited a significant reduction in their levels in the presence of NS-398.	Nitrogen	172-174	interleukin 1 beta	Homo sapiens	25-53
21403634-8	2011	A primary signal, LPS, in conjunction with a secondary signal, ATP, is necessary for the activation of the inflammasome, a multiprotein complex that processes pro-IL-1beta to its mature, bioactive form (4, 5, 6, 8, 9, 10).	Adenosine Triphosphate	63-66	interleukin 1 beta	Homo sapiens	159-171
20848209-0	2011	Upregulation of interleukin-1beta production by 1,25-dihydroxyvitamin D(3) in activated human macrophages.	Calcitriol	48-74	interleukin 1 beta	Homo sapiens	16-33
20971568-4	2011	The consumption of (-)-epigallocatechin 3-gallate (EGCG) has been studied extensively as a potential treatment for a variety of carcinogenic and degenerative diseases due to its ability to suppress a variety of inflammatory and angiogenic factors such as NF-kappaB, IL-1beta, COX2, VEGF, and matrix metalloproteinases.	epigallocatechin gallate	51-55	interleukin 1 beta	Homo sapiens	266-274
21349431-5	2011	In vivo, poly(I:C)-induced type I IFN diminished IL-1beta production in response to alum and Candida albicans, thus increasing susceptibility to this fungal pathogen.	Poly I-C	9-18	interleukin 1 beta	Homo sapiens	49-57
21104991-2	2011	We have previously shown that, in certain cancer cell lines that are typically nonresponsive to cytokine-mediated IL6 induction, activation of the AHR with the agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin derepresses the IL6 promoter and allows for synergistic induction following IL1beta treatment.	Polychlorinated Dibenzodioxins	168-203	interleukin 1 beta	Homo sapiens	280-287
21440087-3	2011	The secretion of the pro-inflammatory cytokines IL-1beta and IFNgamma and that of the anti-inflammatory cytokines IL-1ra and IL-10 induced by cancer cells was decreased by simvastatin but not by pravastatin, whereas that of IL-6 was not affected by both drugs.	Simvastatin	172-183	interleukin 1 beta	Homo sapiens	48-56
21239716-0	2011	Basic calcium phosphate crystals induce monocyte/macrophage IL-1beta secretion through the NLRP3 inflammasome in vitro.	basic calcium phosphate	0-23	interleukin 1 beta	Homo sapiens	60-68
21345222-8	2011	OPN301 significantly decreased Pam3CSK4-induced cytokine production of tumour necrosis factor alpha (TNF-alpha), IL-1beta, IL-6, interferon (IFN)-gamma and IL-8 compared to IgG control in RA PBMCs and SFMCs cultures (all P &lt; 0.05).	opn301	0-6	interleukin 1 beta	Homo sapiens	113-121
21173077-2	2011	We have shown that retinoic acid (RA), which is known to play a necessary role in early events in pregnancy, can combine with transcriptional activators of VEGF (e.g. TPA, TGF-beta, IL-1beta) to rapidly induce VEGF secretion from human endometrial stromal cells through a translational mechanism of action.	Tretinoin	19-32	interleukin 1 beta	Homo sapiens	182-190
21173077-2	2011	We have shown that retinoic acid (RA), which is known to play a necessary role in early events in pregnancy, can combine with transcriptional activators of VEGF (e.g. TPA, TGF-beta, IL-1beta) to rapidly induce VEGF secretion from human endometrial stromal cells through a translational mechanism of action.	Tretinoin	34-36	interleukin 1 beta	Homo sapiens	182-190
21219853-21	2011	CONCLUSION: We demonstrate for the first time that GlcN and BAY can prevent cytokine-induced demethylation of a specific CpG site in the IL1beta promoter and this was associated with decreased expression of IL1beta.	Glucosamine	51-55	interleukin 1 beta	Homo sapiens	137-144
21219853-21	2011	CONCLUSION: We demonstrate for the first time that GlcN and BAY can prevent cytokine-induced demethylation of a specific CpG site in the IL1beta promoter and this was associated with decreased expression of IL1beta.	Glucosamine	51-55	interleukin 1 beta	Homo sapiens	207-214
21257314-7	2011	This is the first report of the inhibitory activity of endogenous fatty acid amides and their analogues on the production of nitric oxide, cytokines (IL-1beta, IL-6, and TNF-alpha) and the chemokine MDC.	Fatty Acids	66-76	interleukin 1 beta	Homo sapiens	150-158
21257314-7	2011	This is the first report of the inhibitory activity of endogenous fatty acid amides and their analogues on the production of nitric oxide, cytokines (IL-1beta, IL-6, and TNF-alpha) and the chemokine MDC.	Amides	77-83	interleukin 1 beta	Homo sapiens	150-158
21235202-6	2011	Chlordane was associated with lower levels of the pro-inflammatory IL-1beta [beta: -0.11 (-0.20, -0.02)].	Chlordan	0-9	interleukin 1 beta	Homo sapiens	67-75
21239716-4	2011	THP-1 cells stimulated with BCP crystals produced IL-1beta in a dose-dependent manner.	bcp	28-31	interleukin 1 beta	Homo sapiens	50-58
21239716-8	2011	Collectively, these results demonstrate that BCP crystals induce IL-1beta secretion through activating the NLRP3 inflammasome.	bcp	45-48	interleukin 1 beta	Homo sapiens	65-73
21239716-9	2011	Furthermore, we speculate that IL-1 blockade could be a novel strategy to inhibit BCP-induced inflammation in human disease.	bcp	82-85	interleukin 1 beta	Homo sapiens	31-35
20974246-6	2011	Experiment 1 confirmed that systemic morphine (20 mg/kg) administered one day after a contusion injury significantly increased expression levels of spinal IL-1beta 24 h later.	Morphine	37-45	interleukin 1 beta	Homo sapiens	155-163
21123173-3	2011	Here, we report a previously undescribed serine phosphorylation of STAT6, which is activated by cell stress or by the pro-inflammatory cytokine, interleukin-1beta (IL-1beta).	Serine	41-47	interleukin 1 beta	Homo sapiens	145-162
21123173-3	2011	Here, we report a previously undescribed serine phosphorylation of STAT6, which is activated by cell stress or by the pro-inflammatory cytokine, interleukin-1beta (IL-1beta).	Serine	41-47	interleukin 1 beta	Homo sapiens	164-172
21123173-6	2011	Inactivation of STAT6 by JNK-dependent Ser-707 phosphorylation may be one mechanism of controlling the balance between IL-1beta and IL-4 signals.	Serine	39-42	interleukin 1 beta	Homo sapiens	119-127
21208635-1	2011	2-Benzo[d]thiazolyl- and 2-benzo[d]isothiazolyl-imino-5-benzylidene-4-thiazolidinone derivatives were investigated as potential metalloproteinases (MMPs) inhibitors and evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1beta, using an experimental model that reproduces the mechanisms involved in osteoarthritic (OA) diseases.	2-benzo[d]thiazolyl- and 2-benzo[d]isothiazolyl-imino-5-benzylidene-4-thiazolidinone	0-84	interleukin 1 beta	Homo sapiens	259-267
21270263-10	2011	Glucose-induced activation of TXNIP mediates IL-1beta mRNA expression levels and intracellular pro-IL-1beta accumulation in adipose tissue.	Glucose	0-7	interleukin 1 beta	Homo sapiens	45-53
21270263-5	2011	Additionally, the role of thioredoxin interacting protein (TXNIP) in glucose-induced IL-1beta production was assessed.	Glucose	69-76	interleukin 1 beta	Homo sapiens	85-93
21270263-7	2011	In human adipose tissue, high glucose resulted in a 10-fold upregulation of TXNIP gene expression levels (P &lt; 0.01) and a 10% elevation of caspase-1 activity (P &lt; 0.05), together with induction of IL-1beta transcription (twofold, P &lt; 0.01) and a significant increase in IL-1beta secretion.	Glucose	30-37	interleukin 1 beta	Homo sapiens	203-211
21270263-10	2011	Glucose-induced activation of TXNIP mediates IL-1beta mRNA expression levels and intracellular pro-IL-1beta accumulation in adipose tissue.	Glucose	0-7	interleukin 1 beta	Homo sapiens	95-107
21270263-7	2011	In human adipose tissue, high glucose resulted in a 10-fold upregulation of TXNIP gene expression levels (P &lt; 0.01) and a 10% elevation of caspase-1 activity (P &lt; 0.05), together with induction of IL-1beta transcription (twofold, P &lt; 0.01) and a significant increase in IL-1beta secretion.	Glucose	30-37	interleukin 1 beta	Homo sapiens	279-287
20940111-8	2011	Cord blood cytokines (IL-1beta, IL-8, IFNgamma, TNFalpha) showed a U-shaped association with U-As at GW30.	u-as	93-97	interleukin 1 beta	Homo sapiens	22-30
21125642-5	2011	PK and Ro also produced a small but detectable increase in IL-1beta release.	4'-chlorodiazepam	7-9	interleukin 1 beta	Homo sapiens	59-67
20650986-0	2011	Steroids induce a disequilibrium of secreted interleukin-1 receptor antagonist and interleukin-1beta synthesis by human neutrophils.	Steroids	0-8	interleukin 1 beta	Homo sapiens	83-100
20650986-5	2011	In vitro, TNF-alpha-stimulated neutrophils produced significant amounts of IL-1beta and sIL-1Ra; this production was inhibited by dexamethasone.	Dexamethasone	130-143	interleukin 1 beta	Homo sapiens	75-83
20650986-6	2011	However, synthesis and secretion of sIL-1Ra was inhibited at lower concentrations dexamethasone compared to IL-1beta, which changed the IL-1beta:sIL-1Ra ratio significantly.	Dexamethasone	82-95	interleukin 1 beta	Homo sapiens	136-144
20650986-9	2011	In conclusion, dexamethasone induces a pro-inflammatory shift in the IL-1beta:sIL-1Ra cytokine balance in neutrophils in vitro, which might contribute to a lack of endogenous anti-inflammatory signals to dampen inflammation in vivo.	Dexamethasone	15-28	interleukin 1 beta	Homo sapiens	69-77
21125642-8	2011	Ro, but not PK, enhanced the LPS-induced release of IL-1beta.	4'-chlorodiazepam	0-2	interleukin 1 beta	Homo sapiens	52-60
21365246-7	2011	The activation of FUT1, FUT2 and FUT4 by IL-1beta is through the NF-kappaB pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway, since they are inhibited specifically by panepoxydone and AG490, respectively.	panepoxydone	210-222	interleukin 1 beta	Homo sapiens	41-49
21125642-9	2011	However, Ro decreased the ATP-induced release of IL-1beta and TNF-alpha, and PK decreased the ATP-induced release of TNF-alpha.	4'-chlorodiazepam	9-11	interleukin 1 beta	Homo sapiens	49-57
21125642-9	2011	However, Ro decreased the ATP-induced release of IL-1beta and TNF-alpha, and PK decreased the ATP-induced release of TNF-alpha.	Adenosine Triphosphate	26-29	interleukin 1 beta	Homo sapiens	49-57
21365246-7	2011	The activation of FUT1, FUT2 and FUT4 by IL-1beta is through the NF-kappaB pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway, since they are inhibited specifically by panepoxydone and AG490, respectively.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	227-232	interleukin 1 beta	Homo sapiens	41-49
20629184-6	2011	RESULTS: Curcumin attenuated lipopolysaccharide (LPS)-stimulated expression and secretion of macrophage inflammatory protein (MIP)-2, interleukin (IL)-1beta, keratinocyte chemoattractant (KC), and MIP-1alpha in colonic epithelial cells (CECs) and in macrophages.	Curcumin	9-17	interleukin 1 beta	Homo sapiens	134-156
21199898-5	2011	In this study, we asked whether IL-1beta was overexpressed, and whether clinical corticosteroid responders differentially regulated IL-1beta expression or release in response to dexamethasone, as compared with nonresponders.	Dexamethasone	178-191	interleukin 1 beta	Homo sapiens	132-140
21199898-11	2011	In vitro exposure of PBMC to dexamethasone from clinical corticosteroid responders suppressed IL-1beta release.	Dexamethasone	29-42	interleukin 1 beta	Homo sapiens	94-102
21372495-6	2011	RESULTS: In ex vivo cultures, raloxifene therapy inhibited LPS-stimulated production of IL-1beta, IL-6, IL-12p40, IL-12p70 and TNF-alpha, but not PHA-stimulated production of IL-4 and IFN-gamma.	Raloxifene Hydrochloride	30-40	interleukin 1 beta	Homo sapiens	88-96
21372495-7	2011	In in vitro cultures, raloxifene at a concentration (10(-9) M) inhibited LPS-stimulated production of IL-1beta, IL-6 and IL-12p40 and PHA-stimulated production of IFN-gamma.	Raloxifene Hydrochloride	22-32	interleukin 1 beta	Homo sapiens	102-110
21372495-8	2011	CONCLUSIONS: Raloxifene therapy decreases the production of IL-1beta, IL-6, IL-12 and TNF-alpha but not that of IL-4 and IFN-gamma, suggesting that modulation of cytokines could play a role in the mechanisms of the osteoprotective effect of raloxifene.	Raloxifene Hydrochloride	13-23	interleukin 1 beta	Homo sapiens	60-68
20706991-1	2011	We investigated the effects of hyaluronan (HA) on interleukin-1beta (IL-1beta)-stimulated matrix metalloproteinase (MMP)-13 production in human chondrocytes from patients with osteoarthritis (OA) or rheumatoid arthritis (RA).	Hyaluronic Acid	31-41	interleukin 1 beta	Homo sapiens	50-67
20663020-8	2011	RESULTS: Pretreatment of PBMCs with alendronate promoted lipid A-induced production of IL-1beta and IL-6, but decreased lipid A-induced IL-8 and MCP-1 production.	Alendronate	36-47	interleukin 1 beta	Homo sapiens	87-95
20663020-8	2011	RESULTS: Pretreatment of PBMCs with alendronate promoted lipid A-induced production of IL-1beta and IL-6, but decreased lipid A-induced IL-8 and MCP-1 production.	Lipid A	57-64	interleukin 1 beta	Homo sapiens	87-95
20706991-1	2011	We investigated the effects of hyaluronan (HA) on interleukin-1beta (IL-1beta)-stimulated matrix metalloproteinase (MMP)-13 production in human chondrocytes from patients with osteoarthritis (OA) or rheumatoid arthritis (RA).	Hyaluronic Acid	31-41	interleukin 1 beta	Homo sapiens	69-77
21167894-7	2011	Treatment of astrocyte cultures with TNF-alpha and IL-1beta caused activation of several signaling molecules and transcription factors crucial to RANTES gene expression, including reactive oxygen species, extracellular signal-regulated kinase, NF-kappaB, and NF-IL6, increased RANTES gene promoter activity, and provoked RANTES production.	Reactive Oxygen Species	180-203	interleukin 1 beta	Homo sapiens	51-59
20860588-0	2011	Carbon monoxide releasing molecule-3 inhibits concurrent tumor necrosis factor-alpha- and interleukin-1beta-induced expression of adhesion molecules on human gingival fibroblasts.	Carbon Monoxide	0-15	interleukin 1 beta	Homo sapiens	90-107
21280192-7	2011	TUDCA treatment decreased nuclear factor kappa B activation and the proinflammatory cytokines interleukin-6 and interleukin-1beta.	ursodoxicoltaurine	0-5	interleukin 1 beta	Homo sapiens	112-129
21178005-8	2011	The secretion of inflammatory cytokine IL-1beta was dependent on ATP, K(+) efflux, and reactive oxygen species, all mediators that activate the inflammasome.	Adenosine Triphosphate	65-68	interleukin 1 beta	Homo sapiens	39-47
21178005-8	2011	The secretion of inflammatory cytokine IL-1beta was dependent on ATP, K(+) efflux, and reactive oxygen species, all mediators that activate the inflammasome.	Reactive Oxygen Species	87-110	interleukin 1 beta	Homo sapiens	39-47
20667995-7	2011	RESULTS: We observed, 28 days after pargyline-mediated blockade of MAO (before or after IR), improved renal function as well as a net decrease in renal inflammation associated to lower IL-1beta and TNF-alpha gene expression.	Pargyline	36-45	interleukin 1 beta	Homo sapiens	185-193
21245324-3	2011	In this cohort of subjects with knee osteoarthritis (OA), synovial fluid uric acid was strongly correlated with synovial fluid IL-18 and IL-1beta.	Uric Acid	73-82	interleukin 1 beta	Homo sapiens	137-145
19854035-6	2011	In the high-tHcy group, tHcy level was also positively correlated with IL-1beta, TNF-alpha, oxLDL, and blood pressure; and negatively correlated with LDL particle size.	thcy	12-16	interleukin 1 beta	Homo sapiens	71-79
19854035-6	2011	In the high-tHcy group, tHcy level was also positively correlated with IL-1beta, TNF-alpha, oxLDL, and blood pressure; and negatively correlated with LDL particle size.	thcy	24-28	interleukin 1 beta	Homo sapiens	71-79
21147546-7	2011	Possible regulatory factors of BDNF expression (tumor necrosis factor-alpha and interleukin-1-beta) were detected both in CAFs and EMT-tumor cells.	cafs	122-126	interleukin 1 beta	Homo sapiens	80-98
21147546-8	2011	In CAFs: IL-1beta-, in SCC-25 cells TNF-alpha-gene-expression was significantly increased in co-culture conditions.	cafs	3-7	interleukin 1 beta	Homo sapiens	9-17
21245324-7	2011	The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1beta) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression.	Uric Acid	112-121	interleukin 1 beta	Homo sapiens	78-86
21112970-7	2011	IL-1beta-induced PGD(2) production is significantly lower in MEFs-arr-2(-/-)-arr-3(-/-) than in wild-type MEFs but can be rescued by expressing Arr2 or Arr3.	Prostaglandin D2	17-23	interleukin 1 beta	Homo sapiens	0-8
20661185-7	2011	Sulfide also lowered the blood IL-6, IL-1beta, and nitrite + nitrate concentrations, which coincided with reduced kidney oxidative DNA base damage and iNOS expression, and attenuated glomerular histological injury as assessed by the incidence of glomerular tubularization.	Sulfides	0-7	interleukin 1 beta	Homo sapiens	37-45
21041719-10	2011	In addition, DAPK knockout reduced uric acid crystal-triggered peritonitis, suggesting that DAPK may serve as a target in the treatment of IL-1beta-associated autoinflammatory diseases.	Uric Acid	35-44	interleukin 1 beta	Homo sapiens	139-147
21148032-5	2011	Furthermore, cisplatin increased the interaction between TLR4 and its microbial ligand LPS, thereby upregulating the production of proinflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, via NF-kappaB activation.	Cisplatin	13-22	interleukin 1 beta	Homo sapiens	177-185
20870807-10	2011	In IL-1beta-treated osteoarthritis chondrocytes, butaprost suppressed MMP-13 production, which was further decreased by COX-2 inhibitor.	butaprost	49-58	interleukin 1 beta	Homo sapiens	3-11
20937349-7	2011	When compared to untreated controls, two irritating ingredients, nonoxynol 9 and benzalkonium chloride, reduced tissue viability to &lt;40% and TEER to &lt;60% while increasing NaFl leakage by 11-24% and IL-1alpha and IL-1beta release by &gt;100%.	Nonoxynol	65-74	interleukin 1 beta	Homo sapiens	218-226
20937349-7	2011	When compared to untreated controls, two irritating ingredients, nonoxynol 9 and benzalkonium chloride, reduced tissue viability to &lt;40% and TEER to &lt;60% while increasing NaFl leakage by 11-24% and IL-1alpha and IL-1beta release by &gt;100%.	Benzalkonium Compounds	81-102	interleukin 1 beta	Homo sapiens	218-226
21051542-1	2011	The NALP3 inflammasome is activated by low intracellular potassium concentrations [K(+)](i), leading to the secretion of the proinflammatory cytokine IL-1beta.	Potassium	57-66	interleukin 1 beta	Homo sapiens	150-158
21051542-7	2011	In vitro, the inhibitors of lysosomal acidification (ammonium chloride, chloroquine) and of aquaporins (mercury chloride, phloretin) all significantly decreased the production of IL-1beta.	Ammonium Chloride	53-70	interleukin 1 beta	Homo sapiens	179-187
21051542-7	2011	In vitro, the inhibitors of lysosomal acidification (ammonium chloride, chloroquine) and of aquaporins (mercury chloride, phloretin) all significantly decreased the production of IL-1beta.	Chloroquine	72-83	interleukin 1 beta	Homo sapiens	179-187
21051542-7	2011	In vitro, the inhibitors of lysosomal acidification (ammonium chloride, chloroquine) and of aquaporins (mercury chloride, phloretin) all significantly decreased the production of IL-1beta.	calomel	104-120	interleukin 1 beta	Homo sapiens	179-187
21051542-7	2011	In vitro, the inhibitors of lysosomal acidification (ammonium chloride, chloroquine) and of aquaporins (mercury chloride, phloretin) all significantly decreased the production of IL-1beta.	Phloretin	122-131	interleukin 1 beta	Homo sapiens	179-187
21051542-8	2011	In vivo, only the pharmacological inhibitor of lysosome acidification chloroquine could be used which again significantly reduced the IL-1beta production.	Chloroquine	70-81	interleukin 1 beta	Homo sapiens	134-142
20862685-1	2011	OBJECTIVE: To investigate the role of histone H3 lysine 4 (H3K4) methylation in interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in human osteoarthritic (OA) chondrocytes.	Lysine	49-55	interleukin 1 beta	Homo sapiens	80-97
20862685-1	2011	OBJECTIVE: To investigate the role of histone H3 lysine 4 (H3K4) methylation in interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in human osteoarthritic (OA) chondrocytes.	Lysine	49-55	interleukin 1 beta	Homo sapiens	99-107
21914170-10	2011	In the presence and absence of IL-1beta, the magnitude of stimulation for [3H]-thymidine and 35SO4 incorporation by dynamic compression was dependent on the concentration of CNP and the response was inhibited with the PKGII inhibitor.	3h]-thymidine	75-88	interleukin 1 beta	Homo sapiens	31-39
21468922-4	2011	Among these MAPKs, only p38 MAPK inhibitor (SB203580) blocked MMP-13 induction and AP-1 activation in IL-1beta-treated SW1353 cells.	SB 203580	44-52	interleukin 1 beta	Homo sapiens	102-110
21468922-7	2011	The JAK2 inhibitor (AG490) blocked STAT1/2 activation as well as MMP-13 induction in IL-1beta-treated SW1353 cells.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	20-25	interleukin 1 beta	Homo sapiens	85-93
21914170-0	2011	Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1beta in chondrocyte/agarose constructs.	Sepharose	124-131	interleukin 1 beta	Homo sapiens	100-108
21914170-10	2011	In the presence and absence of IL-1beta, the magnitude of stimulation for [3H]-thymidine and 35SO4 incorporation by dynamic compression was dependent on the concentration of CNP and the response was inhibited with the PKGII inhibitor.	35so4	93-98	interleukin 1 beta	Homo sapiens	31-39
21550026-8	2011	Furthermore, intermittent exposure of FATEII cells to the exogenous oxidants X/XO and H(2)O(2) upregulated the secretion of pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha; this upregulation was correlated with increasing activity of key glutathione-related enzymes, closely involved with maintaining the cyclic GSH/GSSG equilibrium.	Hydrogen Peroxide	86-94	interleukin 1 beta	Homo sapiens	151-159
22040886-3	2011	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha-induced production and mRNA expression of IL-8, IL-6 and IL-1beta from RA patient-derived fibroblast-like synovial cell line MH7A.	Dihydrotestosterone	33-59	interleukin 1 beta	Homo sapiens	142-150
22040886-3	2011	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha-induced production and mRNA expression of IL-8, IL-6 and IL-1beta from RA patient-derived fibroblast-like synovial cell line MH7A.	Dihydrotestosterone	61-64	interleukin 1 beta	Homo sapiens	142-150
21512226-8	2011	camphorata polysaccharides induce macrophage-derived anti-tumor activities in human hepatoma cells via IL-1beta and Akt activation.	camphorata polysaccharides	0-26	interleukin 1 beta	Homo sapiens	103-111
20632067-4	2011	XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta.	Uric Acid	13-22	interleukin 1 beta	Homo sapiens	151-163
20632067-4	2011	XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta.	Uric Acid	13-22	interleukin 1 beta	Homo sapiens	155-163
20632067-4	2011	XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta.	Reactive Oxygen Species	27-50	interleukin 1 beta	Homo sapiens	151-163
20632067-4	2011	XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta.	Reactive Oxygen Species	27-50	interleukin 1 beta	Homo sapiens	155-163
20959532-5	2011	In THP-1 cells, palmitate increased cellular TLR2 and TLR4 expression, generated reactive oxygen species (ROS), and increased NF-kappaB activity, IL-1beta, and MCP-1 release in a dose- and time-dependent manner.	Palmitates	16-25	interleukin 1 beta	Homo sapiens	146-154
21628878-6	2011	IL-1beta production was also inhibited by SA.	saikosaponin D	42-44	interleukin 1 beta	Homo sapiens	0-8
22112657-9	2011	A significant association was also observed between these two polymorphisms and IL-1beta production by peripheral leukocytes in response to ex vivo lipopolysaccharide stimulation.	ex vivo lipopolysaccharide	140-166	interleukin 1 beta	Homo sapiens	80-88
21309738-2	2011	Lipopolysaccharide-induced secretion of IL-1beta by PMNs from 15 hypertensive and 15 normotensive subjects after incubation with losartan, captopril, amlodipine, atenolol, and hydrochlorothiazide were assessed.	Losartan	129-137	interleukin 1 beta	Homo sapiens	40-48
21309738-2	2011	Lipopolysaccharide-induced secretion of IL-1beta by PMNs from 15 hypertensive and 15 normotensive subjects after incubation with losartan, captopril, amlodipine, atenolol, and hydrochlorothiazide were assessed.	Captopril	139-148	interleukin 1 beta	Homo sapiens	40-48
21309738-2	2011	Lipopolysaccharide-induced secretion of IL-1beta by PMNs from 15 hypertensive and 15 normotensive subjects after incubation with losartan, captopril, amlodipine, atenolol, and hydrochlorothiazide were assessed.	Amlodipine	150-160	interleukin 1 beta	Homo sapiens	40-48
21309738-2	2011	Lipopolysaccharide-induced secretion of IL-1beta by PMNs from 15 hypertensive and 15 normotensive subjects after incubation with losartan, captopril, amlodipine, atenolol, and hydrochlorothiazide were assessed.	Atenolol	162-170	interleukin 1 beta	Homo sapiens	40-48
21309738-2	2011	Lipopolysaccharide-induced secretion of IL-1beta by PMNs from 15 hypertensive and 15 normotensive subjects after incubation with losartan, captopril, amlodipine, atenolol, and hydrochlorothiazide were assessed.	Hydrochlorothiazide	176-195	interleukin 1 beta	Homo sapiens	40-48
21309738-4	2011	Losartan, captopril, and amlodipine caused a concentration-dependent attenuation of IL-1beta levels in both groups.	Losartan	0-8	interleukin 1 beta	Homo sapiens	84-92
21309738-4	2011	Losartan, captopril, and amlodipine caused a concentration-dependent attenuation of IL-1beta levels in both groups.	Captopril	10-19	interleukin 1 beta	Homo sapiens	84-92
21309738-4	2011	Losartan, captopril, and amlodipine caused a concentration-dependent attenuation of IL-1beta levels in both groups.	Amlodipine	25-35	interleukin 1 beta	Homo sapiens	84-92
21509198-0	2011	IFNbeta and glatiramer acetate trigger different signaling pathways to regulate the IL-1 system in multiple sclerosis.	Glatiramer Acetate	12-30	interleukin 1 beta	Homo sapiens	84-88
21509198-3	2011	IL-1beta activity is inhibited by the secreted form of IL-1 receptor antagonist (sIL-1Ra) whose production is increased in patients" blood and induced in human monocytes by IFNbeta and glatiramer acetate (GA)-both immunomodulators displaying similar therapeutic efficacy in MS. Because intracellular pathways are currently considered as potential therapeutic targets, identification of specific kinases used by both immunomodulators might lead to more specific therapeutic targeting.	Glatiramer Acetate	185-203	interleukin 1 beta	Homo sapiens	0-8
21509198-3	2011	IL-1beta activity is inhibited by the secreted form of IL-1 receptor antagonist (sIL-1Ra) whose production is increased in patients" blood and induced in human monocytes by IFNbeta and glatiramer acetate (GA)-both immunomodulators displaying similar therapeutic efficacy in MS. Because intracellular pathways are currently considered as potential therapeutic targets, identification of specific kinases used by both immunomodulators might lead to more specific therapeutic targeting.	Glatiramer Acetate	205-207	interleukin 1 beta	Homo sapiens	0-8
21997700-4	2011	Colchicine is efficacious in the IL-1beta- and inflammasome-mediated diseases gout, familial Mediterranean fever and Behcet"s disease, and therefore a potentially effective drug in HS.	Colchicine	0-10	interleukin 1 beta	Homo sapiens	33-41
21244670-9	2011	Finally, urate crystals, which specifically induce the NLPR3 inflammasome activation, induced significant IL-1beta production in healthy controls but not in patients with sepsis.	Uric Acid	9-14	interleukin 1 beta	Homo sapiens	106-114
21525675-15	2011	The negative correlation of clinical markers of inflammation to the IL-1beta levels in the pigmented gingivitis group could possibly be attributed to the protective role of melanins.	Melanins	173-181	interleukin 1 beta	Homo sapiens	68-76
21461372-3	2011	In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF.	Doxycycline	49-60	interleukin 1 beta	Homo sapiens	112-117
21461372-3	2011	In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF.	Tetracycline	65-77	interleukin 1 beta	Homo sapiens	112-117
21084452-6	2011	Similar to dexamethasone (DEX), CpdA profoundly suppressed lipopolysaccharide-induced TNF-alpha (-63%), IL-1beta (-38%), and IL-6 (-36%) (P &lt; 0.05) mRNA levels.	CPDA	32-36	interleukin 1 beta	Homo sapiens	104-112
21131367-10	2011	IL-1beta also increased IL-17A expression; however, IL-1beta, CARD9 and MyD88 signaling pathways activated by known intrinsic inflammatory mediators were hardly required for the enhanced activity induced by lactic acid.	Lactic Acid	207-218	interleukin 1 beta	Homo sapiens	0-8
20557713-7	2011	Results of Live/Dead and pro-inflammatory cytokine expression analyses showed that the exposure of ARPE-19 cultures to the test materials cross-linked with a concentration &gt;=0.1 mmol EDC/mg GM induces significant cytotoxicity and high levels of interleukin-1beta and interleukin-6.	ethylene dichloride	186-189	interleukin 1 beta	Homo sapiens	248-265
20942594-4	2011	The IL1B C-511T and IL1RN VNTR polymorphisms had an impact on copper metabolism parameters.	Copper	62-68	interleukin 1 beta	Homo sapiens	4-8
20943776-10	2011	Ponalrestat, a specific inhibitor developed to block AKR1B1 activity, reduced PGF2alpha production in response to IL-1beta in both cultured endometrial cells and endometrial explants.	ponalrestat	0-11	interleukin 1 beta	Homo sapiens	114-122
21105164-3	2011	Monocytes/macrophages on biaxially-expanded polytetrafluoroethylene with an average intranodal distance of 4.4 mum (4.4-ePTFE) produced higher levels of the inflammatory cytokine interleukin-1 beta (IL-1beta) compared with monocytes/macrophages on nonporous polytetrafluoroethylene (np-PTFE).	Polytetrafluoroethylene	44-67	interleukin 1 beta	Homo sapiens	179-197
21105164-3	2011	Monocytes/macrophages on biaxially-expanded polytetrafluoroethylene with an average intranodal distance of 4.4 mum (4.4-ePTFE) produced higher levels of the inflammatory cytokine interleukin-1 beta (IL-1beta) compared with monocytes/macrophages on nonporous polytetrafluoroethylene (np-PTFE).	Polytetrafluoroethylene	44-67	interleukin 1 beta	Homo sapiens	199-207
21105164-3	2011	Monocytes/macrophages on biaxially-expanded polytetrafluoroethylene with an average intranodal distance of 4.4 mum (4.4-ePTFE) produced higher levels of the inflammatory cytokine interleukin-1 beta (IL-1beta) compared with monocytes/macrophages on nonporous polytetrafluoroethylene (np-PTFE).	Polytetrafluoroethylene	258-281	interleukin 1 beta	Homo sapiens	179-197
21105164-3	2011	Monocytes/macrophages on biaxially-expanded polytetrafluoroethylene with an average intranodal distance of 4.4 mum (4.4-ePTFE) produced higher levels of the inflammatory cytokine interleukin-1 beta (IL-1beta) compared with monocytes/macrophages on nonporous polytetrafluoroethylene (np-PTFE).	np-ptfe	283-290	interleukin 1 beta	Homo sapiens	179-197
21062339-9	2011	Serum and GCF TNF-alpha and IL-1beta were significantly associated with TC/HDL in the HD group.	Technetium	72-74	interleukin 1 beta	Homo sapiens	28-36
20872780-8	2011	In our experimental RA model, the oral administration of TQ 5 mg/kg/day significantly reduced the serum levels of HNE, IL-1beta and TNFalpha as well as bone turnover markers, such as alkaline phosphatase and tartrate-resistant acid phosphatase.	thymoquinone	57-59	interleukin 1 beta	Homo sapiens	119-127
20943776-10	2011	Ponalrestat, a specific inhibitor developed to block AKR1B1 activity, reduced PGF2alpha production in response to IL-1beta in both cultured endometrial cells and endometrial explants.	Dinoprost	78-87	interleukin 1 beta	Homo sapiens	114-122
22186691-10	2011	The correlations of IL-1beta with PD (p = 0.000) and IL-1beta with BOP (p = 0.0004) were highly significant.	bop	67-70	interleukin 1 beta	Homo sapiens	20-28
22186691-10	2011	The correlations of IL-1beta with PD (p = 0.000) and IL-1beta with BOP (p = 0.0004) were highly significant.	bop	67-70	interleukin 1 beta	Homo sapiens	53-61
22096368-2	2011	Recent studies suggest that orchestration of the MSU-induced inflammatory response is dependent on the proinflammatory cytokine IL-1beta, underlined by promising results in early IL-1 inhibitor trials in gout patients.	msu	49-52	interleukin 1 beta	Homo sapiens	128-136
20980503-5	2011	Ad5 cell entry also induces reactive oxygen species (ROS) production, and inhibitors of ROS prevent Ad-induced IL-1beta release.	Reactive Oxygen Species	88-91	interleukin 1 beta	Homo sapiens	111-119
20382011-4	2011	We found that GPE attenuated TNFalpha-induced expression of inflammatory genes including interleukin (IL)-6, IL-1beta, IL-8, monocyte chemoattractant protein (MCP)-1, cyclooxygenase (COX)-2 and Toll-like receptor (TLR)-2.	gpe	14-17	interleukin 1 beta	Homo sapiens	109-117
20661932-0	2011	Beneficial effects of hyperbaric oxygen on human degenerated intervertebral disk cells via suppression of IL-1beta and p38 MAPK signal.	Oxygen	33-39	interleukin 1 beta	Homo sapiens	106-114
21606625-0	2011	Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1beta-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.	Flavonoids	11-21	interleukin 1 beta	Homo sapiens	67-84
21606625-7	2011	Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1beta-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways.	Flavonoids	52-62	interleukin 1 beta	Homo sapiens	114-122
21606625-7	2011	Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1beta-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways.	Flavones	75-83	interleukin 1 beta	Homo sapiens	114-122
21035559-8	2011	The inhibitor of IkappaBalpha-phosphorylation, BAY 11-7082, blocked the induction of Wnt-5A by IL-1beta in a dose-dependent manner.	3-(4-methylphenylsulfonyl)-2-propenenitrile	47-58	interleukin 1 beta	Homo sapiens	95-103
20628263-8	2011	Using a multiple linear regression analysis, serum IL-1beta was significantly associated with free thyroxine, sIL-2R with triiodothyronine and serum thyrotropin receptor antibody (TRAb) and TNF-alpha with TRAb.	Thyroxine	99-108	interleukin 1 beta	Homo sapiens	51-59
20628263-8	2011	Using a multiple linear regression analysis, serum IL-1beta was significantly associated with free thyroxine, sIL-2R with triiodothyronine and serum thyrotropin receptor antibody (TRAb) and TNF-alpha with TRAb.	Triiodothyronine	122-138	interleukin 1 beta	Homo sapiens	51-59
20936497-0	2011	Interleukin-1beta enhances the intracellular accumulation of cholesterol by up-regulating the expression of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase in podocytes.	Cholesterol	61-72	interleukin 1 beta	Homo sapiens	0-17
20936497-1	2011	The aim of this article is to investigate whether interleukin-1beta (IL-1beta) could regulate the intracellular accumulation of cholesterol and the expression of lipid-metabolism-related regulators in podocytes in vitro and the potential mechanisms.	Cholesterol	128-139	interleukin 1 beta	Homo sapiens	50-67
20936497-1	2011	The aim of this article is to investigate whether interleukin-1beta (IL-1beta) could regulate the intracellular accumulation of cholesterol and the expression of lipid-metabolism-related regulators in podocytes in vitro and the potential mechanisms.	Cholesterol	128-139	interleukin 1 beta	Homo sapiens	69-77
20936497-5	2011	Treatment with IL-1beta or LDL alone increased the contents of intracellular cholesterol (P &lt; 0.05 for both) and lipid droplets, and treatment with both IL-1beta and LDL further increased the accumulation of intracellular cholesterol in podocytes (P &lt; 0.05 vs. LDL alone).	Cholesterol	77-88	interleukin 1 beta	Homo sapiens	15-23
20936497-5	2011	Treatment with IL-1beta or LDL alone increased the contents of intracellular cholesterol (P &lt; 0.05 for both) and lipid droplets, and treatment with both IL-1beta and LDL further increased the accumulation of intracellular cholesterol in podocytes (P &lt; 0.05 vs. LDL alone).	Cholesterol	77-88	interleukin 1 beta	Homo sapiens	156-164
20936497-5	2011	Treatment with IL-1beta or LDL alone increased the contents of intracellular cholesterol (P &lt; 0.05 for both) and lipid droplets, and treatment with both IL-1beta and LDL further increased the accumulation of intracellular cholesterol in podocytes (P &lt; 0.05 vs. LDL alone).	Cholesterol	225-236	interleukin 1 beta	Homo sapiens	15-23
20936497-5	2011	Treatment with IL-1beta or LDL alone increased the contents of intracellular cholesterol (P &lt; 0.05 for both) and lipid droplets, and treatment with both IL-1beta and LDL further increased the accumulation of intracellular cholesterol in podocytes (P &lt; 0.05 vs. LDL alone).	Cholesterol	225-236	interleukin 1 beta	Homo sapiens	156-164
21035557-0	2011	Selenomethionine inhibits IL-1beta inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes.	Selenomethionine	0-16	interleukin 1 beta	Homo sapiens	26-34
21035557-8	2011	RESULTS: SeMet inhibited chondrocyte gene expression of IL-1beta induced iNOS (31-54%, P=0.031) and COX2 (50-65%, P=0.031) with corresponding reductions in both NO (19-47%, P=0.031) and PGE2 (24-32%, P=0.031) production.	Dinoprostone	186-190	interleukin 1 beta	Homo sapiens	56-64
22195044-1	2011	BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1beta (IL-1beta).	Uric Acid	134-150	interleukin 1 beta	Homo sapiens	196-213
22164217-8	2011	The results show that Annexin A1 can negatively regulate phosphorylation of p38 and release of IL-1beta, IL-6 and TNF-alpha in THP-1 cells following propofol intervention and lipopolysaccharide (LPS) stimulation.	Propofol	149-157	interleukin 1 beta	Homo sapiens	95-103
22164217-9	2011	Our results clearly indicate that propofol can up-regulate Annexin A1 to inhibit the phosphorylation level of p38 and release of IL-1beta, IL-6 and TNF-alpha, so as to inhibit inflammatory response.	Propofol	34-42	interleukin 1 beta	Homo sapiens	129-137
22194879-8	2011	Furthermore, the inhibitory effects of IGF-1 or/and PDGF-bb on IL-1beta-induced NF-kappaB activation were sensitive to inhibitors of Src (PP1), PI-3K (wortmannin) and Akt (SH-5), suggesting that the pathway consisting of non-receptor tyrosine kinase (Src), phosphatidylinositol 3-kinase and protein kinase B must be involved in IL-1beta signaling.	Wortmannin	151-161	interleukin 1 beta	Homo sapiens	63-71
22195044-1	2011	BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1beta (IL-1beta).	Uric Acid	134-150	interleukin 1 beta	Homo sapiens	215-223
22195044-1	2011	BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1beta (IL-1beta).	Uric Acid	152-155	interleukin 1 beta	Homo sapiens	196-213
22195044-1	2011	BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1beta (IL-1beta).	Uric Acid	152-155	interleukin 1 beta	Homo sapiens	215-223
21779360-4	2011	Our findings showed that pretreatment of HaCaT cells with NaHS (a donor of H(2)S) for 30 min before exposure to CoCl(2) for 24 h significantly attenuated CoCl(2)-induced injuries and inflammatory responses, evidenced by increases in cell viability and GSH level and decreases in ROS generation and secretions of IL-1beta, IL-6 and IL-8.	sodium bisulfide	58-62	interleukin 1 beta	Homo sapiens	312-320
21915284-3	2011	It has recently been shown that an activator of the P2X7/inflammasome pathway, ATP, and the resultant products (IL-1beta/IL-18) are increased in COPD patients.	Adenosine Triphosphate	79-82	interleukin 1 beta	Homo sapiens	112-120
21915284-6	2011	We have demonstrated that CS-induced neutrophilia in a pre-clinical model is temporally associated with markers of inflammasome activation, (increased caspase 1 activity and release of IL-1beta/IL-18) in the lungs.	Cesium	26-28	interleukin 1 beta	Homo sapiens	185-193
22135702-5	2011	ROS generation by the cells and serum levels of TNF-alpha and IL-1-beta are abundant both in the patients and their relatives.	Reactive Oxygen Species	0-3	interleukin 1 beta	Homo sapiens	62-71
22039452-0	2011	Quercetin inhibits IL-1beta-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts from Graves" orbitopathy.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	19-27
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	165-173
22039452-4	2011	Increased hyaluronan production induced by IL-1beta or tumor necrosis factor-alpha was suppressed by quercetin in a dose- and time-dependent manner.	Hyaluronic Acid	10-20	interleukin 1 beta	Homo sapiens	43-82
22039452-4	2011	Increased hyaluronan production induced by IL-1beta or tumor necrosis factor-alpha was suppressed by quercetin in a dose- and time-dependent manner.	Quercetin	101-110	interleukin 1 beta	Homo sapiens	43-82
21931678-6	2011	We found that, even though sirtinol treatment alone affected only long-term cell proliferation, it diminishes HDMEC inflammatory responses to tumor necrosis factor (TNF)alpha and interleukin (IL)-1beta.	sirtinol	27-35	interleukin 1 beta	Homo sapiens	179-201
21931678-7	2011	In fact, sirtinol significantly reduced membrane expression of adhesion molecules in TNFa- or IL-1beta-stimulated cells, as well as the amount of CXCL10 and CCL2 released by HDMEC following TNFalpha treatment.	sirtinol	9-17	interleukin 1 beta	Homo sapiens	94-102
21779360-4	2011	Our findings showed that pretreatment of HaCaT cells with NaHS (a donor of H(2)S) for 30 min before exposure to CoCl(2) for 24 h significantly attenuated CoCl(2)-induced injuries and inflammatory responses, evidenced by increases in cell viability and GSH level and decreases in ROS generation and secretions of IL-1beta, IL-6 and IL-8.	Hydrogen Sulfide	75-80	interleukin 1 beta	Homo sapiens	312-320
21779360-6	2011	Similar to the protective effect of H(2)S, both NS-398 (a selective COX-2 inhibitor) and PDTC (a selective NF-kappaB inhibitor) depressed not only CoCl(2)-induced cytotoxicity, but also the secretions of IL-1beta, IL-6 and IL-8.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	48-54	interleukin 1 beta	Homo sapiens	204-212
20959451-0	2010	Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia.	Nitric Oxide	70-82	interleukin 1 beta	Homo sapiens	29-48
21625475-7	2011	SUA correlated positively with IL-6, TNF-alpha and CRP and negatively with IL-1beta (Spearman r: 0.04, 0.07, 0.20 and 0.05 in men, and 0.09, 0.13, 0.30 and 0.07 in women, respectively, P&lt;0.05).	sua	0-3	interleukin 1 beta	Homo sapiens	75-83
21625475-8	2011	In multivariable analyses, SUA was associated positively with CRP (beta coefficient +- SE = 0.35+-0.02, P&lt;0.001), TNF-alpha (0.08+-0.02, P&lt;0.001) and IL-6 (0.10+-0.03, P&lt;0.001), and negatively with IL-1beta (-0.07+-0.03, P = 0.027).	sua	27-30	interleukin 1 beta	Homo sapiens	207-215
21625475-10	2011	CONCLUSIONS: SUA was associated positively with IL-6, CRP and TNF-alpha and negatively with IL-1beta, particularly in women.	sua	13-16	interleukin 1 beta	Homo sapiens	92-100
21633494-7	2011	We show that STBM can bind to monocytes and B cells and induce cytokine release (TNFalpha, MIP-1alpha, IL-1alpha, IL-1beta, IL-6, IL-8).	stbm	13-17	interleukin 1 beta	Homo sapiens	114-122
20959451-0	2010	Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia.	Nitric Oxide	70-82	interleukin 1 beta	Homo sapiens	50-60
20959451-4	2010	Microglial cells stimulated with LPS and ATP responded with a massive release of IL-1beta, as measured by ELISA.	Adenosine Triphosphate	41-44	interleukin 1 beta	Homo sapiens	81-89
21047091-0	2010	Water in the polar and nonpolar cavities of the protein interleukin-1beta.	Water	0-5	interleukin 1 beta	Homo sapiens	56-73
21417548-9	2011	IL-1beta and TNF strongly increased PGE2 production, with IL-1beta as the most prominent inducer.	Dinoprostone	36-40	interleukin 1 beta	Homo sapiens	0-8
21041296-8	2010	Expression of active CPAF in human cells caused a mild reduction in IkappaBalpha phosphorylation but a strong reduction in NF-kappaB reporter activity in response to interleukin-1beta.	1-O-hexadecyl-2-N-methylcarbamol -sn-glycerol-3-phosphocholine	21-25	interleukin 1 beta	Homo sapiens	166-183
20934436-9	2010	Exposure to high glucose and/or tumor necrosis factor-alpha which is known to be a factor that induces insulin resistance, enhanced the mRNA levels of DUSP1, ANXA1, IL1B, S100A8, IL22RA2, S100A9 and IRF1 in human monocyte-like U937 cells.	Glucose	17-24	interleukin 1 beta	Homo sapiens	165-169
21047091-2	2010	The nonpolar cavity in the protein interleukin-1beta has been reported to be filled by water on the basis of some experiments and simulations and to be empty on the basis of others.	Water	87-92	interleukin 1 beta	Homo sapiens	35-52
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	interleukin 1 beta	Homo sapiens	148-156
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Resveratrol	43-52	interleukin 1 beta	Homo sapiens	148-156
21365847-0	2010	[The effects of oxymatrine on expression of interleukin-6 and interleukin-1beta mRNA of human periodontal ligament cell stimulated by lipopolysaccharides].	oxymatrine	16-26	interleukin 1 beta	Homo sapiens	62-79
20678173-5	2010	All HZ/trophozoite/15-HETE effects on MMP-9 activity and TNF/IL-1beta production were abrogated by quercetin, artemisinin and parthenolide, inhibitors of IkappaBalpha phosphorylation and subsequent degradation, NF-kappaB nuclear translocation, and NF-kappaB-p65 binding to DNA respectively.	Quercetin	99-108	interleukin 1 beta	Homo sapiens	61-69
20678173-5	2010	All HZ/trophozoite/15-HETE effects on MMP-9 activity and TNF/IL-1beta production were abrogated by quercetin, artemisinin and parthenolide, inhibitors of IkappaBalpha phosphorylation and subsequent degradation, NF-kappaB nuclear translocation, and NF-kappaB-p65 binding to DNA respectively.	artemisinin	110-121	interleukin 1 beta	Homo sapiens	61-69
20678173-5	2010	All HZ/trophozoite/15-HETE effects on MMP-9 activity and TNF/IL-1beta production were abrogated by quercetin, artemisinin and parthenolide, inhibitors of IkappaBalpha phosphorylation and subsequent degradation, NF-kappaB nuclear translocation, and NF-kappaB-p65 binding to DNA respectively.	parthenolide	126-138	interleukin 1 beta	Homo sapiens	61-69
21619866-11	2010	These mechanisms seem to be inverted in MS and other chronic neurodegenerative disorders because activated microglia and peripherally derived macrophages are shifted towards a strongly pro-inflammatory phenotype and produce the proinflammatory cytokines TNF-alpha and interleukin (IL)1-beta, as well as potentially neurotoxic substances including nitric oxide, oxygen radicals and proteolytic enzymes.	Nitric Oxide	347-359	interleukin 1 beta	Homo sapiens	268-290
21619866-11	2010	These mechanisms seem to be inverted in MS and other chronic neurodegenerative disorders because activated microglia and peripherally derived macrophages are shifted towards a strongly pro-inflammatory phenotype and produce the proinflammatory cytokines TNF-alpha and interleukin (IL)1-beta, as well as potentially neurotoxic substances including nitric oxide, oxygen radicals and proteolytic enzymes.	Reactive Oxygen Species	361-376	interleukin 1 beta	Homo sapiens	268-290
20582713-5	2010	RESULTS: Treatment with 50 mmol/L glucose markedly increased the level of IL-1beta, IL-18, TNF-alpha, PGE2, NO, TGF-beta1, MCP-1, MIP-1alpha, and RANTES.	Glucose	34-41	interleukin 1 beta	Homo sapiens	74-82
21365847-1	2010	OBJECTIVE: To observe the effects of oxymatrine on the expression of interleukin-6 (IL-6), interleukin-1beta (IL-1beta) mRNA of human periodontal ligament cell (PDLC) stimulated by lipopolysaccharides (LPS), and to discuss oxymatrine"s inhibition mechanism on periodontal inflammation stimulated by LPS.	oxymatrine	37-47	interleukin 1 beta	Homo sapiens	91-108
20582713-6	2010	Honokiol (~20 mumol/L) treatment inhibited the HG-induced expression of inflammatory cytokines such as IL-1beta, IL-18, TNF-alpha, PGE2, NO, and TGF-beta1 in a dose-dependent manner.	honokiol	0-8	interleukin 1 beta	Homo sapiens	103-111
21365847-1	2010	OBJECTIVE: To observe the effects of oxymatrine on the expression of interleukin-6 (IL-6), interleukin-1beta (IL-1beta) mRNA of human periodontal ligament cell (PDLC) stimulated by lipopolysaccharides (LPS), and to discuss oxymatrine"s inhibition mechanism on periodontal inflammation stimulated by LPS.	oxymatrine	37-47	interleukin 1 beta	Homo sapiens	110-118
21365847-5	2010	CONCLUSION: Oxymatrine can restrain the expression of IL-6 and IL-1beta mRNA of human PDLC stimulated by LPS.	oxymatrine	12-22	interleukin 1 beta	Homo sapiens	63-71
20840837-10	2010	Indomethacin was unable to reverse the decrease of iNOS, but it could restore the IL-1beta expression and decrease the IL-10 expression in CORM-2-treated cells.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	82-90
20843944-9	2010	We confirmed significant down-regulation of a number of genes that have been well characterized as progesterone sensitive (IL-1B, IL-6, PTGS2, and GJA1).	Progesterone	99-111	interleukin 1 beta	Homo sapiens	123-128
21181369-0	2010	Effect of lipoxin A4 on IL-1beta production of monocytes and its possible mechanism in severe preeclampsia.	lipoxin A4	10-20	interleukin 1 beta	Homo sapiens	24-32
21181369-1	2010	This study examined in vitro effect of lipoxin A(4) (LXA(4)) on interleukin-1beta (IL-1beta) production of monocytes and its possible mechanism in severe preeclampsia (PE).	lipoxin A4	39-48	interleukin 1 beta	Homo sapiens	64-81
21181369-1	2010	This study examined in vitro effect of lipoxin A(4) (LXA(4)) on interleukin-1beta (IL-1beta) production of monocytes and its possible mechanism in severe preeclampsia (PE).	lipoxin A4	39-48	interleukin 1 beta	Homo sapiens	83-91
21181369-1	2010	This study examined in vitro effect of lipoxin A(4) (LXA(4)) on interleukin-1beta (IL-1beta) production of monocytes and its possible mechanism in severe preeclampsia (PE).	N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide	53-56	interleukin 1 beta	Homo sapiens	64-81
21181369-1	2010	This study examined in vitro effect of lipoxin A(4) (LXA(4)) on interleukin-1beta (IL-1beta) production of monocytes and its possible mechanism in severe preeclampsia (PE).	N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide	53-56	interleukin 1 beta	Homo sapiens	83-91
21181369-8	2010	It was concluded that LXA(4) may inhibit the IL-1beta production of monocytes from severe preeclampsia women by inhibiting extracellular calcium influx.	lipoxin A4	22-28	interleukin 1 beta	Homo sapiens	45-53
21181369-8	2010	It was concluded that LXA(4) may inhibit the IL-1beta production of monocytes from severe preeclampsia women by inhibiting extracellular calcium influx.	Calcium	137-144	interleukin 1 beta	Homo sapiens	45-53
20849904-6	2010	In controls, LL-37 levels inversely correlated with tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta, and IL-22 levels.	Cathelicidin	13-18	interleukin 1 beta	Homo sapiens	93-101
20849904-8	2010	LL-37 enhanced IFN-gamma, IL-4, IL-13, and TNF-alpha secretion from CD3/CD28-stimulated T cells, suppressed TNF-alpha, IL-1beta, IL-6, and IL-10 secretion from lipopolysaccharide-stimulated monocytes, and IL-17, IL-22, IL-1beta, IL-6, and IL-10 secretion from CD3/CD28-stimulated T cells.	Cathelicidin	0-5	interleukin 1 beta	Homo sapiens	119-127
20849904-8	2010	LL-37 enhanced IFN-gamma, IL-4, IL-13, and TNF-alpha secretion from CD3/CD28-stimulated T cells, suppressed TNF-alpha, IL-1beta, IL-6, and IL-10 secretion from lipopolysaccharide-stimulated monocytes, and IL-17, IL-22, IL-1beta, IL-6, and IL-10 secretion from CD3/CD28-stimulated T cells.	Cathelicidin	0-5	interleukin 1 beta	Homo sapiens	219-227
20840837-11	2010	The results suggest that CO induced COX-2 expression and PGE2 production through activating the Akt, PKG, and MAPK pathways, and CO-induced PGE2 may modulate inflammation during macrophage activation by suppressing IL-1beta expression and inducing IL-10 production.	Dinoprostone	140-144	interleukin 1 beta	Homo sapiens	215-223
20933033-10	2010	Moreover, alpha-TQ could decrease the formation of reactive oxygen species (ROS) and NO, and modulate the production of cytokines by decreasing TNF-alpha and IL-1beta and increasing IL-4 formation in microglia.	alpha-tq	10-18	interleukin 1 beta	Homo sapiens	158-166
20667563-7	2010	The expression of interleukin-1beta, tumor necrosis factor-alpha, and S100a4/6/9/10/11/12 genes in peripheral leukocytes, and the serum tumor necrosis factor-alpha protein levels were suppressed by switching to miglitol.	miglitol	211-219	interleukin 1 beta	Homo sapiens	18-64
20807762-4	2010	Interleukin-1beta and tumor necrosis factor-alpha induced a time- and dose-dependent increase in S-SMase secretion and activity, coincident with selective elevations in cellular C(16)-ceramide.	Palmitic Acid	178-183	interleukin 1 beta	Homo sapiens	0-49
20955686-3	2010	For example, a palmitic acid containing sequence pal-Tyr-Val-Ala-Asp-glyoxal was demonstrated to be an extremely effective inhibitor of caspase-1, inhibiting not only the action of the protease against synthetic fluorogenic substrates (K(i)=0.3 nM) but also blocking its processing of pro-interleukin-1beta (pro-IL-1beta).	Palmitic Acid	15-28	interleukin 1 beta	Homo sapiens	285-306
20955686-3	2010	For example, a palmitic acid containing sequence pal-Tyr-Val-Ala-Asp-glyoxal was demonstrated to be an extremely effective inhibitor of caspase-1, inhibiting not only the action of the protease against synthetic fluorogenic substrates (K(i)=0.3 nM) but also blocking its processing of pro-interleukin-1beta (pro-IL-1beta).	Palmitic Acid	15-28	interleukin 1 beta	Homo sapiens	312-320
20955686-3	2010	For example, a palmitic acid containing sequence pal-Tyr-Val-Ala-Asp-glyoxal was demonstrated to be an extremely effective inhibitor of caspase-1, inhibiting not only the action of the protease against synthetic fluorogenic substrates (K(i)=0.3 nM) but also blocking its processing of pro-interleukin-1beta (pro-IL-1beta).	pal-tyr-val-ala-asp-glyoxal	49-76	interleukin 1 beta	Homo sapiens	285-306
20955686-3	2010	For example, a palmitic acid containing sequence pal-Tyr-Val-Ala-Asp-glyoxal was demonstrated to be an extremely effective inhibitor of caspase-1, inhibiting not only the action of the protease against synthetic fluorogenic substrates (K(i)=0.3 nM) but also blocking its processing of pro-interleukin-1beta (pro-IL-1beta).	pal-tyr-val-ala-asp-glyoxal	49-76	interleukin 1 beta	Homo sapiens	312-320
21190604-0	2010	[The effect of Janus kinase 2 inhibitor AG490 on renal tubular epithelial-myofibroblast transdifferentiation induced by interleukin-1beta].	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	40-45	interleukin 1 beta	Homo sapiens	120-137
21190604-1	2010	OBJECTIVE: To investigate the effect of AG490, a Janus kinase 2 inhibitor, on epithelial-myofibroblast transdifferentiation induced by interleukin-1beta (IL-1beta).	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	40-45	interleukin 1 beta	Homo sapiens	135-152
21190604-1	2010	OBJECTIVE: To investigate the effect of AG490, a Janus kinase 2 inhibitor, on epithelial-myofibroblast transdifferentiation induced by interleukin-1beta (IL-1beta).	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	40-45	interleukin 1 beta	Homo sapiens	154-162
21190604-7	2010	The administration of AG490 could restore the expression of CK-18 (24 hours: 1.07+-0.07, 48 hours: 0.93+-0.06, 72 hours: 0.83+-0.06), and inhibit the expression of alpha-SMA induced by IL-1beta (24 hours: 0.33+- 0.01, 48 hours: 0.52+-0.01, 72 hours: 0.61+-0.04).	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	22-27	interleukin 1 beta	Homo sapiens	185-193
20807762-4	2010	Interleukin-1beta and tumor necrosis factor-alpha induced a time- and dose-dependent increase in S-SMase secretion and activity, coincident with selective elevations in cellular C(16)-ceramide.	Ceramides	184-192	interleukin 1 beta	Homo sapiens	0-49
21067602-12	2010	In contrast, CFA injection led to minor microglial morphological changes and an induction of IkappaB-alpha mRNA in the CVO regions; a significant increase in IL-1beta and IL-6 mRNA started only at 48 hours post-injection, when the induced pain-related behavior started to resolve.	3-chloro-4-fluoroaniline	13-16	interleukin 1 beta	Homo sapiens	158-166
21062492-5	2010	The spinal cords of sALS (n = 8), but not control subjects (n = 4), were infiltrated by interleukin-1beta- (IL-1beta-), and tumor necrosis factor-alpha-positive macrophages (co-localizing with neurons), IL-17A-positive CD8 cells, and IL-17A-positive mast cells.	sals	20-24	interleukin 1 beta	Homo sapiens	88-105
20883667-1	2010	The MAPK/ERK pathway is involved in IL-1beta-induced cyclooxygenase (COX-2) expression and prostaglandin E2 (PGE2) production; two factors that play important roles in OA pathogenesis.	Dinoprostone	91-107	interleukin 1 beta	Homo sapiens	36-44
20883667-2	2010	In the present study, we find that IL-1beta induced COX-2 expression and PGE2 production in human chondrocytes via a process that required the activation of the MAPK/ERK pathway.	Dinoprostone	73-77	interleukin 1 beta	Homo sapiens	35-43
20688046-2	2010	Nevertheless, after stimulation of various human cell lines with IL-1beta/TNFalpha and simultaneous treatment with DMC PGE(2) synthesis is inhibited [1].	Prostaglandins E	119-122	interleukin 1 beta	Homo sapiens	65-73
21035753-2	2010	Several factors contribute to the induction of islet-derived IL-1beta, including glucose, free fatty acids, and leptin.	Glucose	81-88	interleukin 1 beta	Homo sapiens	61-69
21035753-2	2010	Several factors contribute to the induction of islet-derived IL-1beta, including glucose, free fatty acids, and leptin.	Fatty Acids, Nonesterified	90-106	interleukin 1 beta	Homo sapiens	61-69
20670615-9	2010	Moreover, ATP-induced YO-PRO-1(2+) uptake and IL-1beta release were abrogated in cells co-incubated with TGF-beta1.	Adenosine Triphosphate	10-13	interleukin 1 beta	Homo sapiens	46-54
20873968-5	2010	Two of the CPs (IG33 and LL33), derivatives from LL37, potentiated S. aureus LTA induced TNFalpha, IL-6 and IL-1beta production in whole blood.	cps	11-14	interleukin 1 beta	Homo sapiens	108-116
20732999-8	2010	Taken together, the present data suggest that apoptosis of HZ-fed monocytes is prevented through a cascade involving 15-HETE-mediated upregulation of IL-1beta transcription, rapidly sustained by chemokine, TNF-alpha, MMP-9, and IL-1RA transcription and upregulation of HSP27 protein expression.	15-hydroxy-5,8,11,13-eicosatetraenoic acid	117-124	interleukin 1 beta	Homo sapiens	150-158
20728939-5	2010	Furthermore, we provide evidence that Poly I:C induced expression of IL-1beta, TNFalpha, IL-12p70 and IFN-beta was blocked by JNK inhibitor SP600125.	Poly I-C	38-46	interleukin 1 beta	Homo sapiens	69-77
20728939-5	2010	Furthermore, we provide evidence that Poly I:C induced expression of IL-1beta, TNFalpha, IL-12p70 and IFN-beta was blocked by JNK inhibitor SP600125.	pyrazolanthrone	140-148	interleukin 1 beta	Homo sapiens	69-77
20659513-7	2010	Delivery of PI(4,5)P(2) into microglia increased the expression of interleukin-1beta and tumor necrosis factor alpha.	pi(4,5)p(2)	12-23	interleukin 1 beta	Homo sapiens	67-116
20691236-6	2010	The treatment with IndOH-NC markedly inhibited the levels of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha levels even 48 h after OGD.	indoh-nc	19-27	interleukin 1 beta	Homo sapiens	92-100
20949640-10	2010	Human islets also responded to beta-GalCer (10 microg/mL) by secreting TNFalpha, IL-1beta and IL-8, whereas sulfatide partly inhibited the effect of LPS.	beta-GalCer	31-42	interleukin 1 beta	Homo sapiens	81-89
20647545-6	2010	Although parthenolide and BMS-345541 had no inhibitory effects on osteoblast function, celastrol prevented IL1beta-induced TAK1 activation and inhibited osteoblast growth, differentiation, and bone nodule formation.	celastrol	87-96	interleukin 1 beta	Homo sapiens	107-114
20929277-6	2010	In conclusion, our study demonstrates significantly high serum levels of IL-1beta in patients with MC + HCV with and without AT compared with healthy controls.	mc + hcv	99-107	interleukin 1 beta	Homo sapiens	73-81
20872576-5	2010	We demonstrated that titanium induces IL-1beta secretion from macrophages.	Titanium	21-29	interleukin 1 beta	Homo sapiens	38-46
20872576-9	2010	Together, these results suggest that titanium particle-induced acute inflammation is due to activation of the NALP3 inflammasome, which leads to increased IL-1beta secretion and IL-1-associated signaling, including neutrophil recruitment.	Titanium	37-45	interleukin 1 beta	Homo sapiens	155-163
20512787-5	2010	Glutamine, leucine and proline all reduced NF-kappaB activity after 3 h of IL-1beta stimulation at 2, 5 and 10 mM (p&lt;0.001).	Glutamine	0-9	interleukin 1 beta	Homo sapiens	75-83
20512787-5	2010	Glutamine, leucine and proline all reduced NF-kappaB activity after 3 h of IL-1beta stimulation at 2, 5 and 10 mM (p&lt;0.001).	Leucine	11-18	interleukin 1 beta	Homo sapiens	75-83
20512787-5	2010	Glutamine, leucine and proline all reduced NF-kappaB activity after 3 h of IL-1beta stimulation at 2, 5 and 10 mM (p&lt;0.001).	Proline	23-30	interleukin 1 beta	Homo sapiens	75-83
20876102-1	2010	Glatiramer acetate (GA), an immunomodulator used in multiple sclerosis (MS) therapy, induces the production of secreted IL-1 receptor antagonist (sIL-1Ra), a natural inhibitor of IL-1beta, in human monocytes, and in turn enhances sIL-1Ra circulating levels in MS patients.	Glatiramer Acetate	0-18	interleukin 1 beta	Homo sapiens	179-187
21078271-9	2010	Also compound of AKBA and ATO inhibited secretions of TNF-alpha and IL-1beta in THP-1 cells and cell coculture system (P&lt;0.01).	Arsenic Trioxide	26-29	interleukin 1 beta	Homo sapiens	68-76
21241575-0	2010	[Effect of silica on expression of interleukin-1beta of lung alveolus macrophages in patients with silicosis].	Silicon Dioxide	11-17	interleukin 1 beta	Homo sapiens	35-52
20419322-7	2010	RESULTS: Preincubation of the mesothelial monolayer with IL-1beta and TNF-alpha resulted in enhanced tumor cell adhesion of SGC-7901 and MKN-45 cells.	mesothelial	30-41	interleukin 1 beta	Homo sapiens	57-65
20727382-1	2010	Previously, we demonstrated that IL-1beta was able to increase iron efflux from glial cells through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis.	Iron	63-67	interleukin 1 beta	Homo sapiens	33-41
20522791-3	2010	OBJECTIVES: The present study determined if fibroblasts from subjects with COPD overproduce PGE2 after stimulation with the inflammatory cytokines IL-1beta and tumor necrosis factor-alpha, and further defined the mechanism for overproduction.	Dinoprostone	92-96	interleukin 1 beta	Homo sapiens	147-187
20876102-1	2010	Glatiramer acetate (GA), an immunomodulator used in multiple sclerosis (MS) therapy, induces the production of secreted IL-1 receptor antagonist (sIL-1Ra), a natural inhibitor of IL-1beta, in human monocytes, and in turn enhances sIL-1Ra circulating levels in MS patients.	Glatiramer Acetate	20-22	interleukin 1 beta	Homo sapiens	179-187
20876102-1	2010	Glatiramer acetate (GA), an immunomodulator used in multiple sclerosis (MS) therapy, induces the production of secreted IL-1 receptor antagonist (sIL-1Ra), a natural inhibitor of IL-1beta, in human monocytes, and in turn enhances sIL-1Ra circulating levels in MS patients.	CHEMBL2402005	150-153	interleukin 1 beta	Homo sapiens	179-187
20615556-1	2010	Treatment of SK-N-SH cells with morphine and interleukin-1beta (IL-1beta) produced dual regulation of the mRNA for the human mu opioid receptor (MOR) protein.	sk-n	13-17	interleukin 1 beta	Homo sapiens	45-62
20615556-1	2010	Treatment of SK-N-SH cells with morphine and interleukin-1beta (IL-1beta) produced dual regulation of the mRNA for the human mu opioid receptor (MOR) protein.	sk-n	13-17	interleukin 1 beta	Homo sapiens	64-72
20615556-4	2010	Morphine-mediated down-regulation of MOR was blocked by naltrexone and IL-1beta-induced up-regulation of MOR was blocked by interleukin-1 receptor type 1 antagonist.	Morphine	0-8	interleukin 1 beta	Homo sapiens	71-79
20529668-10	2010	CONCLUSIONS: The IL-1beta -31T allele was positively associated with a risk of NSCLC, and the carriers of IL-1beta -31T/T or -511C/C would have a higher risk of suffering from NSCLC if they drank alcohol or smoke heavily.	Alcohols	196-203	interleukin 1 beta	Homo sapiens	106-114
20876102-1	2010	Glatiramer acetate (GA), an immunomodulator used in multiple sclerosis (MS) therapy, induces the production of secreted IL-1 receptor antagonist (sIL-1Ra), a natural inhibitor of IL-1beta, in human monocytes, and in turn enhances sIL-1Ra circulating levels in MS patients.	sil-1ra	146-153	interleukin 1 beta	Homo sapiens	179-187
21034601-9	2010	RESULTS: Y316 blocked TNF production and inhibited the upregulation of TNF mRNA levels in response to LPS, and also prevented the production of IL-1 and IL-6.	y316	9-13	interleukin 1 beta	Homo sapiens	144-148
20621084-7	2010	Sappanchalcone is seen to inhibit LPS-stimulated nitric oxide (NO), prostaglandin E(2) (PGE(2)), interlukine-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interlukine-6 (IL-6) and interlukine-12 (IL-12) release in addition to inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in HPDL cells.	sappanchalcone	0-14	interleukin 1 beta	Homo sapiens	116-124
20707612-4	2010	More detailed diagnostic tests at later stages of action of TCDD in HepG2 cells revealed that induction of IL-1beta, BAFF, and iNOS are largely mediated by the protein kinase-dependent non-genomic route.	Polychlorinated Dibenzodioxins	60-64	interleukin 1 beta	Homo sapiens	107-115
20188355-0	2010	Cyclooxygenase-2 in testes of infertile men: evidence for the induction of prostaglandin synthesis by interleukin-1beta.	Prostaglandins	75-88	interleukin 1 beta	Homo sapiens	102-119
20961828-5	2010	RESULTS: Compared with the control group, the IT group had smaller increases in plasma concentrations of tumor necrosis factor alpha, interleukin 1beta (IL-1beta), IL-6, and cTnI, and had a more pronounced increase in IL-10 levels after the initiation of CPB.	Isoleucyl-Threonine	46-48	interleukin 1 beta	Homo sapiens	134-151
20961828-5	2010	RESULTS: Compared with the control group, the IT group had smaller increases in plasma concentrations of tumor necrosis factor alpha, interleukin 1beta (IL-1beta), IL-6, and cTnI, and had a more pronounced increase in IL-10 levels after the initiation of CPB.	Isoleucyl-Threonine	46-48	interleukin 1 beta	Homo sapiens	153-161
20531350-4	2010	DESIGN: The effect of RSV on interleukin 1beta (IL1beta)-induced change of adipokine mRNA gene expression and secretion were measured in human adipose tissue explants.	Resveratrol	22-25	interleukin 1 beta	Homo sapiens	29-46
20531350-4	2010	DESIGN: The effect of RSV on interleukin 1beta (IL1beta)-induced change of adipokine mRNA gene expression and secretion were measured in human adipose tissue explants.	Resveratrol	22-25	interleukin 1 beta	Homo sapiens	48-55
20726535-2	2010	We demonstrate that monoclonal antibodies against interleukin-1beta and tumor necrosis factor-alpha were still active when conjugated to high molecular weight polysaccharides.	Polysaccharides	159-174	interleukin 1 beta	Homo sapiens	50-99
20726535-4	2010	To explore this new class of protein-polysaccharide conjugates, we covalently modified interleukin-1beta and tumor necrosis factor-alpha monoclonal antibodies with high molecular weight hyaluronic acid and carboxymethylcellulose.	Polysaccharides	37-51	interleukin 1 beta	Homo sapiens	87-136
20726535-4	2010	To explore this new class of protein-polysaccharide conjugates, we covalently modified interleukin-1beta and tumor necrosis factor-alpha monoclonal antibodies with high molecular weight hyaluronic acid and carboxymethylcellulose.	Carboxymethylcellulose Sodium	206-228	interleukin 1 beta	Homo sapiens	87-136
20726535-8	2010	While all conjugates had pM-level binding constants, they ranged from 40 pM for the hyaluronic acid-(anti-interleukin-1beta) conjugate to 412 pM for the carboxymethylcellulose-(anti-interleukin-1beta) conjugate.	Hyaluronic Acid	84-99	interleukin 1 beta	Homo sapiens	106-123
20724602-6	2010	In confluent leukocyte-free term DCs, secreted interleukin-6 levels in incubations with estradiol-17beta were increased 2500-fold by IL-1beta (P &lt; 0.05).	Estradiol	88-104	interleukin 1 beta	Homo sapiens	133-141
20727522-9	2010	N-3 supplementation also decreased the lymphocyte, monocyte, TNF-alpha, IL-6 and IL-1beta levels.	Nitrogen	0-1	interleukin 1 beta	Homo sapiens	81-89
20426787-7	2010	Moreover, treatment with a SIRT1 activator, resveratrol, significantly suppressed IL-1beta-mediated induction of MMP-1, which was attenuated by pretreatment with EX-527.	Resveratrol	44-55	interleukin 1 beta	Homo sapiens	82-90
20531350-6	2010	Concomitant incubations with RSV reversed the IL1beta-stimulated secretion (16-36%) and gene expression (25-48%) of these adipokines.	Resveratrol	29-32	interleukin 1 beta	Homo sapiens	46-53
20531350-7	2010	IL1beta reduced adiponectin mRNA expression (40%), a decrement that was reversed by RSV treatment.	Resveratrol	84-87	interleukin 1 beta	Homo sapiens	0-7
20835230-3	2010	One therapy for type 2 diabetes, glyburide, suppressed IAPP-mediated IL-1beta production in vitro.	Glyburide	33-42	interleukin 1 beta	Homo sapiens	69-77
20435591-7	2010	CONCLUSIONS: Poly(I:C) induces the expression of MMP-1 and MMP-3 in human corneal fibroblasts in a manner dependent on activation of the transcription factor NF-kappaB and on IL-1beta secretion.	Poly I-C	13-21	interleukin 1 beta	Homo sapiens	175-183
20170929-0	2010	Plasma interleukin-1beta concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged nonoverweight and overweight Japanese men.	Glucose	82-89	interleukin 1 beta	Homo sapiens	7-24
20170929-6	2010	Plasma IL-1beta and IL-6 levels in nonoverweight subjects were positively and strongly associated with fasting blood glucose and hemoglobin A(1c); in contrast, these cytokines were strongly associated with homeostasis model assessment of insulin resistance and fasting glucose in overweight subjects.	Glucose	117-124	interleukin 1 beta	Homo sapiens	7-15
20170929-6	2010	Plasma IL-1beta and IL-6 levels in nonoverweight subjects were positively and strongly associated with fasting blood glucose and hemoglobin A(1c); in contrast, these cytokines were strongly associated with homeostasis model assessment of insulin resistance and fasting glucose in overweight subjects.	Glucose	269-276	interleukin 1 beta	Homo sapiens	7-15
20170929-7	2010	Significant positive associations between plasma IL-1beta and glucose concentrations were observed within the groups classified according to glucose concentrations, after adjustment for age and body mass index.	Glucose	62-69	interleukin 1 beta	Homo sapiens	49-57
20170929-7	2010	Significant positive associations between plasma IL-1beta and glucose concentrations were observed within the groups classified according to glucose concentrations, after adjustment for age and body mass index.	Glucose	141-148	interleukin 1 beta	Homo sapiens	49-57
20170929-8	2010	The results of our current study show that plasma IL-1beta levels are strongly associated with fasting blood glucose concentrations in healthy and preclinical nonoverweight and overweight Japanese men.	Glucose	109-116	interleukin 1 beta	Homo sapiens	50-58
20835230-4	2010	Processing of IL-1beta initiated by IAPP first required priming, a process that involved glucose metabolism and was facilitated by minimally oxidized low-density lipoprotein.	Glucose	89-96	interleukin 1 beta	Homo sapiens	14-22
20927194-10	2010	RESULTS: The two proinflammatory cytokines, TNF-alpha and IL-1beta, were able to activate the reporter system, translating the activation of the NF-kappaB signaling pathway and NF-kappaB inhibitors, BAY 11-7082, caffeic acid phenethyl ester and MG132 were efficient.	3-(4-methylphenylsulfonyl)-2-propenenitrile	199-210	interleukin 1 beta	Homo sapiens	58-66
20095820-5	2010	Following differentiation, alkaline phosphatase (ALP) and calcium contents of IL-1beta-treated MSC were significantly reduced by high doses of COX-2 inhibitors compared with the low-dose group.	Calcium	58-65	interleukin 1 beta	Homo sapiens	78-86
21174772-7	2010	TSSN treatment significantly attenuated mRNA of inflammatory mediators such as COX-2, IL-1beta, IL-6 while increased PPAR-gamma gene and protein expression.	tssn	0-4	interleukin 1 beta	Homo sapiens	86-94
20927194-10	2010	RESULTS: The two proinflammatory cytokines, TNF-alpha and IL-1beta, were able to activate the reporter system, translating the activation of the NF-kappaB signaling pathway and NF-kappaB inhibitors, BAY 11-7082, caffeic acid phenethyl ester and MG132 were efficient.	caffeic acid phenethyl ester	212-240	interleukin 1 beta	Homo sapiens	58-66
20927194-10	2010	RESULTS: The two proinflammatory cytokines, TNF-alpha and IL-1beta, were able to activate the reporter system, translating the activation of the NF-kappaB signaling pathway and NF-kappaB inhibitors, BAY 11-7082, caffeic acid phenethyl ester and MG132 were efficient.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	245-250	interleukin 1 beta	Homo sapiens	58-66
20720456-7	2010	Interestingly, microRNA-based PIP5K alpha knockdown strongly reduced ganglioside-induced transcription of proinflammatory cytokines IL-1 beta and TNFalpha.	Gangliosides	69-80	interleukin 1 beta	Homo sapiens	132-141
21150487-5	2010	Moreover, treatment with CL-IB-MECA inhibited microglial activation and reduced the expression of proinflammatory cytokines including tumour necrosis factor-alpha and interleukin-1beta.	2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide	25-35	interleukin 1 beta	Homo sapiens	167-184
20696864-4	2010	Surprisingly, however, whereas mRNA expression and cellular release of TNF-alpha, the beta form of pro-IL-1 (IL-1beta), and IL-6 were inhibited by the leptomycin B-induced nuclear IkappaBalpha, IL-8 mRNA expression and cellular release were not significantly affected.	leptomycin B	151-163	interleukin 1 beta	Homo sapiens	109-117
20538801-4	2010	WPBs could also contain tPA, and in IL-1beta-treated cells, IL-8, IL-6, MCP-1, and GRO-alpha, and were the primary source for histamine or ionomycin-stimulated secretion of these molecules.	Ionomycin	139-148	interleukin 1 beta	Homo sapiens	36-44
20851349-6	2010	The activity correlated well with processing of prointerleukin-1beta and prointerleukin-18 in phorbol 12-myristate 13-acetate (PMA)-stimulated cells.	Tetradecanoylphorbol Acetate	94-125	interleukin 1 beta	Homo sapiens	48-68
20851349-6	2010	The activity correlated well with processing of prointerleukin-1beta and prointerleukin-18 in phorbol 12-myristate 13-acetate (PMA)-stimulated cells.	Tetradecanoylphorbol Acetate	127-130	interleukin 1 beta	Homo sapiens	48-68
20822529-4	2010	In this study, we tested the hypothesis that upregulation of HO-1 would inhibit production of the free radical (NO) by interleukin (IL)-1beta-activated human astrocytes.	Free Radicals	98-110	interleukin 1 beta	Homo sapiens	119-141
20605224-4	2010	Antagonism of D(1), but not D(2), receptors within the BLA blocked the suppressive effect of heroin-associated environmental stimuli on iNOS, TNF-alpha and IL-1beta.	Heroin	93-99	interleukin 1 beta	Homo sapiens	156-164
20420825-6	2010	Moreover, the inflammatory cytokine IL-1beta, either exogenously added or produced by CD14(+) monocytes in culture, could trigger expression of high levels of PGE(2) by hUC-MSCs, whereas inclusion of the IL-1 receptor antagonist (IL-1RA) in the culture down-regulated not only PGE(2) expression, but also reversed the promotional effect of CD14(+) monocytes and partially restored CD4(+) and CD8(+) T cell proliferation and IFN-gamma secretion.	Prostaglandins E	159-162	interleukin 1 beta	Homo sapiens	36-44
20420825-6	2010	Moreover, the inflammatory cytokine IL-1beta, either exogenously added or produced by CD14(+) monocytes in culture, could trigger expression of high levels of PGE(2) by hUC-MSCs, whereas inclusion of the IL-1 receptor antagonist (IL-1RA) in the culture down-regulated not only PGE(2) expression, but also reversed the promotional effect of CD14(+) monocytes and partially restored CD4(+) and CD8(+) T cell proliferation and IFN-gamma secretion.	Prostaglandins E	277-280	interleukin 1 beta	Homo sapiens	36-44
20822529-10	2010	Pretreatment with hemin alone substantially induced both HO-1 mRNA and protein expression, and HO-1 mRNA expression was further enhanced when hemin was combined with IL-1beta treatment.	Hemin	18-23	interleukin 1 beta	Homo sapiens	166-174
20822529-12	2010	When pretreated with SnPP, the inhibitory effect of hemin on IL-1beta-induced NO production and iNOS expression was reversed, suggesting the involvement of HO-1.	S-Nitroso-N-propionyl-D,L-penicillamine	21-25	interleukin 1 beta	Homo sapiens	61-69
20626741-5	2010	Enhanced serum concentrations of interleukin (IL)-1alpha and IL-1beta were observed in cITP (P &lt; 10(-3) ) and blood donor (P = 0 04) carriers of the IL1RN*2.	citp	87-91	interleukin 1 beta	Homo sapiens	61-69
20561679-0	2010	The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture.	Silicon Dioxide	48-54	interleukin 1 beta	Homo sapiens	96-104
20561679-1	2010	Although amorphous silica particles (SPs) are widely used in cosmetics, foods and medicinal products, it has gradually become evident that SPs can induce substantial inflammation accompanied by interleukin-1beta (IL-1beta) production.	Silicon Dioxide	19-25	interleukin 1 beta	Homo sapiens	213-221
20561679-1	2010	Although amorphous silica particles (SPs) are widely used in cosmetics, foods and medicinal products, it has gradually become evident that SPs can induce substantial inflammation accompanied by interleukin-1beta (IL-1beta) production.	Silicon Dioxide	139-142	interleukin 1 beta	Homo sapiens	194-211
20561679-1	2010	Although amorphous silica particles (SPs) are widely used in cosmetics, foods and medicinal products, it has gradually become evident that SPs can induce substantial inflammation accompanied by interleukin-1beta (IL-1beta) production.	Silicon Dioxide	139-142	interleukin 1 beta	Homo sapiens	213-221
20561679-3	2010	We compared IL-1beta production levels in THP-1 human macrophage like cells in response to unmodified SP of various diameters (30- to 1000-nm) and demonstrated that unmodified microsized 1000-nm SP (mSP1000) induced higher levels of IL-1beta production than did smaller unmodified SPs.	Silicon Dioxide	102-104	interleukin 1 beta	Homo sapiens	12-20
20561679-3	2010	We compared IL-1beta production levels in THP-1 human macrophage like cells in response to unmodified SP of various diameters (30- to 1000-nm) and demonstrated that unmodified microsized 1000-nm SP (mSP1000) induced higher levels of IL-1beta production than did smaller unmodified SPs.	Silicon Dioxide	195-197	interleukin 1 beta	Homo sapiens	12-20
20561679-4	2010	Furthermore, we found that unmodified mSP1000-induced IL-1beta production was depended on the sequence of reactive oxygen species (ROS) production, endosomal rupture, and subsequent activation of pro-inflammatory complex NLRP3 inflammasome.	Reactive Oxygen Species	106-129	interleukin 1 beta	Homo sapiens	54-62
20561679-4	2010	Furthermore, we found that unmodified mSP1000-induced IL-1beta production was depended on the sequence of reactive oxygen species (ROS) production, endosomal rupture, and subsequent activation of pro-inflammatory complex NLRP3 inflammasome.	Reactive Oxygen Species	131-134	interleukin 1 beta	Homo sapiens	54-62
20471972-12	2010	The present study suggests that baicalin inhibits IL-1beta induction of MMP-1 by altering the mRNA and protein levels.	baicalin	32-40	interleukin 1 beta	Homo sapiens	50-58
20561679-6	2010	Although unmodified and surface-modified mSP1000s were taken up with similar frequencies equally into the THP-1 cells, surface modification of mSP1000 dramatically suppressed IL-1beta production by reducing ROS production.	Reactive Oxygen Species	207-210	interleukin 1 beta	Homo sapiens	175-183
20823594-9	2010	The results of all parameters indicate that microspheres containing atorvastatin calcium were capable of improving functional outcome, attenuating the expression of TNF-alpha, IL-1beta and IL-6; lowering lipid peroxidation levels and maintaining the preservation of the cellular uniformity.	Atorvastatin	68-88	interleukin 1 beta	Homo sapiens	176-184
20884859-3	2010	Stimulation of primary human corneal epithelial cells, keratocytes, and retinal endothelial cells with 1 to 10 ng/mL interleukin 1beta (IL-1beta) resulted in a significant increase in numerous inflammatory cytokines, including IL-6, IL-8, and tumor necrosis factor alpha (TNF-alpha); and dexamethasone was able to significantly inhibit these effects.	Dexamethasone	288-301	interleukin 1 beta	Homo sapiens	117-134
20603779-6	2010	In experiments on adipocytes treated at day 14 post-differentiation, JTE-907, a synthetic cannabinoid, upregulated the expression of key inflammatory markers - IL-6, MCP-1 and IL-1 beta - and angiogenic factors - VEGF and ANGPTL4 - at 10 microM after 20 h of treatment, having also increased the expression of TRPV1 at 10 microM.	Cannabinoids	90-101	interleukin 1 beta	Homo sapiens	176-185
20884859-3	2010	Stimulation of primary human corneal epithelial cells, keratocytes, and retinal endothelial cells with 1 to 10 ng/mL interleukin 1beta (IL-1beta) resulted in a significant increase in numerous inflammatory cytokines, including IL-6, IL-8, and tumor necrosis factor alpha (TNF-alpha); and dexamethasone was able to significantly inhibit these effects.	Dexamethasone	288-301	interleukin 1 beta	Homo sapiens	136-144
20560877-0	2010	Leptin and interleukin-1beta modulate neuronal glutamate release and protect against glucose-oxygen-serum deprivation.	Glutamic Acid	47-56	interleukin 1 beta	Homo sapiens	11-28
20816188-9	2010	After ozone exposure, atopic asthmatic subjects had significantly increased sputum IL-6 and IL-1beta levels and airway macrophage Toll-like receptor 4, Fc(epsilon)RI, and CD23 expression; values in healthy volunteers and atopic nonasthmatic subjects showed no significant change.	Ozone	6-11	interleukin 1 beta	Homo sapiens	92-100
20717945-7	2010	RESULTS: IL-1 beta regulation of COX-2 mRNA and protein levels was dose and time dependent and IL-1 beta altered PGE(2) metabolism, via regulation of both synthetic and degradative enzymes.	Prostaglandins E	113-117	interleukin 1 beta	Homo sapiens	9-18
20717945-7	2010	RESULTS: IL-1 beta regulation of COX-2 mRNA and protein levels was dose and time dependent and IL-1 beta altered PGE(2) metabolism, via regulation of both synthetic and degradative enzymes.	Prostaglandins E	113-117	interleukin 1 beta	Homo sapiens	95-104
20470889-2	2010	According to a widely accepted hypothesis interleukin-1beta induces the synthesis of cyclooxygenase-2 at the blood-brain interface, which produces prostaglandins that diffuse into brain parenchyma to activate neurons.	Prostaglandins	147-161	interleukin 1 beta	Homo sapiens	42-59
20470889-3	2010	We studied the role of brain cyclooxygenase-2 in interleukin-1beta-induced fever, neuroendocrine and behavioral responses and cellular activation by intracerebroventricular infusion of the cyclooxygenase-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	216-222	interleukin 1 beta	Homo sapiens	49-66
20470889-6	2010	These findings moderate the prevailing view and indicate that brain cyclooxygenase-2-dependent prostaglandin production is important to activation of the median preoptic and arcuate hypothalamus, but not necessarily involved in fever, rises in plasma corticosterone and anorexia after peripheral interleukin-1beta administration.	Prostaglandins	95-108	interleukin 1 beta	Homo sapiens	296-313
20633667-9	2010	Inhibition of both p38alpha and p38gamma with BIRB796 resulted in less inhibition of MMP-13 production in response to IL-1beta or FN-f than did inhibition of only p38alpha with SB203580.	doramapimod	46-53	interleukin 1 beta	Homo sapiens	118-126
20936723-2	2010	The inflammasome can activate caspase-1, and later makes the pro-IL-1beta, proIL-18 precursor mature by cleavaging, thereby mediates the innate immunity.	proil	75-80	interleukin 1 beta	Homo sapiens	61-73
20804602-5	2010	RESULTS: TauCl (600 microM) inhibited MMP-13, but not MMP-1, expression in IL-1beta-stimulated RA FLSs.	N-chlorotaurine	9-14	interleukin 1 beta	Homo sapiens	75-83
21151531-0	2010	Interleukin-1beta expression is required for lysophosphatidic Acid-induced lymphangiogenesis in human umbilical vein endothelial cells.	lysophosphatidic acid	45-66	interleukin 1 beta	Homo sapiens	0-17
21151531-2	2010	Interleukin- (IL-) 1beta, a proinflammatory cytokine, is elevated upon LPA treatment in human umbilical vein endothelial cells (HUVECs).	lysophosphatidic acid	71-74	interleukin 1 beta	Homo sapiens	0-24
21151531-4	2010	However, the relationships between LPA-induced VEGF-C and IL-1beta expressions are not clear.	lysophosphatidic acid	35-38	interleukin 1 beta	Homo sapiens	58-66
21151531-7	2010	Our results suggest that LPA-stimulated lymphangiogenesis in HUVECs is mediated through IL-1beta-induced VEGF-C expression.	lysophosphatidic acid	25-28	interleukin 1 beta	Homo sapiens	88-96
20338073-4	2010	Uro-A and Uro-B (10 microm) inhibited PGE2 production (85 and 40 %, respectively) after IL-1beta stimulation, whereas EA did not show any effect.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	0-5	interleukin 1 beta	Homo sapiens	88-96
20338073-4	2010	Uro-A and Uro-B (10 microm) inhibited PGE2 production (85 and 40 %, respectively) after IL-1beta stimulation, whereas EA did not show any effect.	urolithin B	10-15	interleukin 1 beta	Homo sapiens	88-96
20338073-12	2010	Taking into account that Uro did not enter the cells, a competitive binding for IL-1beta membrane receptor cannot be discarded.	3-(1H-imidazol-4-yl)propanoic acid	25-28	interleukin 1 beta	Homo sapiens	80-88
20506157-9	2010	Finally, the bisphosphonate ibandronate, that hindered activation of the MEK/ERK pathway significantly inhibited both basal and IL-1beta dependent RANKL expression by cells.	Diphosphonates	13-27	interleukin 1 beta	Homo sapiens	128-136
20506157-9	2010	Finally, the bisphosphonate ibandronate, that hindered activation of the MEK/ERK pathway significantly inhibited both basal and IL-1beta dependent RANKL expression by cells.	Ibandronic Acid	28-39	interleukin 1 beta	Homo sapiens	128-136
21328888-1	2010	The paper presents the results of studying the effect of 10% perfluorane (PF) emulsion intravenously injected 1-2 days before surgical treatment for rhegmatogenous retinal detachment on the levels of the cytokines IL-1beta, TNF-alpha, IL-6, and IL-4 in the serum and subretinal fluid of patients.	perfluorane	61-72	interleukin 1 beta	Homo sapiens	214-222
21328888-1	2010	The paper presents the results of studying the effect of 10% perfluorane (PF) emulsion intravenously injected 1-2 days before surgical treatment for rhegmatogenous retinal detachment on the levels of the cytokines IL-1beta, TNF-alpha, IL-6, and IL-4 in the serum and subretinal fluid of patients.	pf	74-76	interleukin 1 beta	Homo sapiens	214-222
21328888-2	2010	PF infusion was found to exert an immunomodulatory effect that favored a short-term increase in the serum level of proinflammatory cytokines (IL- 1beta and IL-6) at week 1 and TNF-alpha on day 1) with their gradual normalization.	pf	0-2	interleukin 1 beta	Homo sapiens	142-151
20649564-11	2010	IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	interleukin 1 beta	Homo sapiens	0-8
19937041-0	2010	Chlorogenic acid attenuates adhesion molecules upregulation in IL-1beta-treated endothelial cells.	Chlorogenic Acid	0-16	interleukin 1 beta	Homo sapiens	63-71
19937041-6	2010	Chlorogenic acid dose-dependently suppressed IL-1beta-induced mRNA expression of vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1 and endothelial cell selectin.	Chlorogenic Acid	0-16	interleukin 1 beta	Homo sapiens	45-53
19937041-7	2010	Chlorogenic acid also suppressed the IL-1beta-induced production of ROS.	Chlorogenic Acid	0-16	interleukin 1 beta	Homo sapiens	37-45
19937041-7	2010	Chlorogenic acid also suppressed the IL-1beta-induced production of ROS.	ros	68-71	interleukin 1 beta	Homo sapiens	37-45
19937041-8	2010	We also observed that chlorogenic acid attenuated or blocked IL-1beta-induced nuclear translocation of nuclear factor-kappaB subunits p50 and p65, which in turn attenuated CAM expression at the transcription level.	Chlorogenic Acid	22-38	interleukin 1 beta	Homo sapiens	61-69
19937041-9	2010	Furthermore, chlorogenic acid significantly reduced the adhesion of human monocyte cells (U937) to IL-1beta-treated HUVECs in a dose-response manner.	Chlorogenic Acid	13-29	interleukin 1 beta	Homo sapiens	99-107
20360457-8	2010	Peripheral blood monocytes and erythrocytes from subjects homozygous for gain-of-function P2X(7) haplotypes exhibited increased ATP-induced ethidium(+) uptake and (86)Rb(+) efflux, respectively, and this correlated with increased IL-1beta secretion from LPS-primed monocytes.	Adenosine Triphosphate	128-131	interleukin 1 beta	Homo sapiens	230-238
20398664-9	2010	RESULTS: TcdA and TcdB triggered inflammasome activation and IL-1beta secretion in macrophages and human mucosal biopsy specimens.	tcda	9-13	interleukin 1 beta	Homo sapiens	61-69
20398664-9	2010	RESULTS: TcdA and TcdB triggered inflammasome activation and IL-1beta secretion in macrophages and human mucosal biopsy specimens.	trimethylaminocarboxyldihydroboran	18-22	interleukin 1 beta	Homo sapiens	61-69
20560877-0	2010	Leptin and interleukin-1beta modulate neuronal glutamate release and protect against glucose-oxygen-serum deprivation.	Glucose	85-92	interleukin 1 beta	Homo sapiens	11-28
20560877-0	2010	Leptin and interleukin-1beta modulate neuronal glutamate release and protect against glucose-oxygen-serum deprivation.	Oxygen	93-99	interleukin 1 beta	Homo sapiens	11-28
20560877-8	2010	Pre-treating GOSD neurons with leptin and IL-1beta in combined significantly increased their survival but decreased their releases of glutamate.	Glutamic Acid	134-143	interleukin 1 beta	Homo sapiens	42-50
20560877-9	2010	The results indicate that leptin may act through Akt and ERK signaling pathways to protect neurons from GOSD insult; the protection was in part IL-1beta dependent and through which the glutamate release from GOSD neurons was inhibited.	Glutamic Acid	185-194	interleukin 1 beta	Homo sapiens	144-152
20576636-10	2010	CONCLUSIONS: Our findings revealed that detectable serum levels of IL-1beta on the day of oocyte retrieval in patients undergoing COS and ICSI are predictive of successful implantation and ongoing pregnancy.	carbonyl sulfide	130-133	interleukin 1 beta	Homo sapiens	67-75
20493226-3	2010	However, a diminished induction of apoptosis of CD4(+) T lymphocytes and monocytes was observed in SLE patients with the 1513 AC genotype, and the release of IL-1beta upon stimulation with ATP was significantly decreased in SLE patients.	Adenosine Triphosphate	189-192	interleukin 1 beta	Homo sapiens	158-166
20610647-6	2010	Moreover, KdPT reduced IL-1beta-mediated generation of intracellular reactive oxygen species, which contributed to IL-1beta-mediated cytokine induction.	Reactive Oxygen Species	69-92	interleukin 1 beta	Homo sapiens	23-31
20432452-6	2010	IL-1beta-stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses.	U 0126	51-56	interleukin 1 beta	Homo sapiens	0-8
20432452-6	2010	IL-1beta-stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses.	pyrazolanthrone	60-68	interleukin 1 beta	Homo sapiens	0-8
20432452-7	2010	IL-1beta-stimulated ICAM-1 gene expression was attenuated by pretreatment with U0126, SP600125, tanshinone IIA, or helenalin, revealed by ICAM-1 promoter assay and real-time RT-PCR analysis.	U 0126	79-84	interleukin 1 beta	Homo sapiens	0-8
20364347-10	2010	IL-1beta increased (P = 0.05) 24 h post-exercise in the high compared to the low CHO condition.	cho	81-84	interleukin 1 beta	Homo sapiens	0-8
20432452-3	2010	Here, we demonstrated that IL-1beta induces ICAM-1 gene expression via the de novo protein synthesis through transcription and translation, which is attenuated by pretreatment with actinomycin D and cycloheximide, respectively.	Dactinomycin	181-194	interleukin 1 beta	Homo sapiens	27-35
20432452-3	2010	Here, we demonstrated that IL-1beta induces ICAM-1 gene expression via the de novo protein synthesis through transcription and translation, which is attenuated by pretreatment with actinomycin D and cycloheximide, respectively.	Cycloheximide	199-212	interleukin 1 beta	Homo sapiens	27-35
20432452-5	2010	Moreover, IL-1beta-stimulated NF-kappaB p65 translocation was blocked by helenalin, but not by U0126 or SP600125, revealing that MAPKs and NF-kappaB pathways were independent on these responses.	helenalin	73-82	interleukin 1 beta	Homo sapiens	10-18
20484148-6	2010	Both physiological and supraphysiological concentrations of testosterone reduced the expression and secretion of TNF-alpha and reduced the expression of IL-1 beta, but did not affect the expression of IL6 or CRP.	Testosterone	60-72	interleukin 1 beta	Homo sapiens	153-162
20610647-6	2010	Moreover, KdPT reduced IL-1beta-mediated generation of intracellular reactive oxygen species, which contributed to IL-1beta-mediated cytokine induction.	Reactive Oxygen Species	69-92	interleukin 1 beta	Homo sapiens	115-123
20610647-8	2010	Analysis of the crystal structure of the complex between IL-1beta/IL-1R type I (IL-1RI), followed by computer modeling of KdPT and subsequent modeling of the peptide receptor complex with the crystal structure of IL-1RI via manual docking, further predicted that the tripeptide, through several H-bonds and one hydrophobic bond, interacts with the IL-1RI.	tripeptide K-26	267-277	interleukin 1 beta	Homo sapiens	57-65
20337887-0	2010	Flutamide inhibits nifedipine- and interleukin-1 beta-induced collagen overproduction in gingival fibroblasts.	Flutamide	0-9	interleukin 1 beta	Homo sapiens	35-53
20337887-1	2010	BACKGROUND AND OBJECTIVE: To understand the role of the androgen receptor in gingival overgrowth, the effects of flutamide on interleukin-1 beta- and nifedipine-induced gene expression of connective tissue growth factor (CTGF/CCN2) and collagen production in gingival fibroblasts were examined.	Flutamide	113-122	interleukin 1 beta	Homo sapiens	126-144
20412422-6	2010	Production of PGE(2) by Ca9-22 cells was enhanced by co-incubation with OxLDL and interleukin-1 beta (IL-1 beta).	Prostaglandins E	14-17	interleukin 1 beta	Homo sapiens	82-100
20412422-6	2010	Production of PGE(2) by Ca9-22 cells was enhanced by co-incubation with OxLDL and interleukin-1 beta (IL-1 beta).	Prostaglandins E	14-17	interleukin 1 beta	Homo sapiens	102-111
20337887-8	2010	Flutamide, an androgen receptor antagonist, inhibited stimulation by nifedipine or interleukin-1 beta.	Flutamide	0-9	interleukin 1 beta	Homo sapiens	83-101
20412422-7	2010	Scavenger receptor inhibitors, fucoidan and dextran sulfate, inhibited the OxLDL-induced IL-8 and PGE(2) production in the presence of IL-1 beta.	fucoidan	31-39	interleukin 1 beta	Homo sapiens	135-144
20226872-7	2010	Roflumilast N-oxide also attenuated [methyl-(3)H] thymidine incorporation secondary to bFGF by about 75% with half-maximum inhibition at 0.7 nM when cells were co-incubated with IL-1beta (10 pg ml(-1)).	n-oxide	12-19	interleukin 1 beta	Homo sapiens	178-186
20412422-7	2010	Scavenger receptor inhibitors, fucoidan and dextran sulfate, inhibited the OxLDL-induced IL-8 and PGE(2) production in the presence of IL-1 beta.	Dextran Sulfate	44-59	interleukin 1 beta	Homo sapiens	135-144
20434582-4	2010	Thus, secretion of IL-1beta decreased significantly when cells were depleted of NLRP3 or treated with the anti-inflammatory inhibitors parthenolide or Bay 11-7082, which inhibit inflammasomes and the transcription factor NF-kappaB.	parthenolide	135-147	interleukin 1 beta	Homo sapiens	19-27
20434582-4	2010	Thus, secretion of IL-1beta decreased significantly when cells were depleted of NLRP3 or treated with the anti-inflammatory inhibitors parthenolide or Bay 11-7082, which inhibit inflammasomes and the transcription factor NF-kappaB.	3-(4-methylphenylsulfonyl)-2-propenenitrile	151-162	interleukin 1 beta	Homo sapiens	19-27
20453712-7	2010	In both adult and neonatal neutrophils, MEHP stimulated IL-1beta and VEGF production, whereas IL-8 production was stimulated only in adult cells.	mono-(2-ethylhexyl)phthalate	40-44	interleukin 1 beta	Homo sapiens	56-64
20489206-3	2010	Indeed, LTB(4) potently up-regulated/stabilized interleukin-1beta-induced COX-2 mRNA and protein expression under conditions of COX-2 inhibitor-dependent blockade of PGE(2) release in human synovial fibroblasts (EC(50) = 16.5 + or - 1.7 nm for mRNA; 19 + or - 2.4 nm for protein, n = 4).	Prostaglandins E	166-169	interleukin 1 beta	Homo sapiens	48-65
20421217-9	2010	At similar concentrations, MS-275 and SAHA suppressed LPS-induced NF-kappaB p65 nuclear accumulation and IL-1beta, IL-6, IL-18 and TNF-alpha secretion in THP-1 monocytic cells.	entinostat	27-33	interleukin 1 beta	Homo sapiens	105-113
20421217-9	2010	At similar concentrations, MS-275 and SAHA suppressed LPS-induced NF-kappaB p65 nuclear accumulation and IL-1beta, IL-6, IL-18 and TNF-alpha secretion in THP-1 monocytic cells.	Vorinostat	38-42	interleukin 1 beta	Homo sapiens	105-113
20434477-15	2010	Using dexamethasone as an immunosuppressive drug for anti-inflammatory therapy, we found a significant reduction of GM-CSF, IL-1beta, and IFN-gamma.	Dexamethasone	6-19	interleukin 1 beta	Homo sapiens	124-132
20630114-14	2010	The IL-1beta induced-MMP-13 gene expression was decreased maximally by GlcN-S, while the reduction of induced-MMP-3 gene expression was greatest with GlcN-HCl.	Glucosamine	71-77	interleukin 1 beta	Homo sapiens	4-12
20668705-6	2010	Importantly, cholesterol crystals induced dose-dependent secretion of mature IL-1beta from human monocytes and macrophages.	Cholesterol	13-24	interleukin 1 beta	Homo sapiens	77-85
20668705-7	2010	The cholesterol crystal-induced secretion of IL-1beta was caspase-1-dependent, suggesting the involvement of an inflammasome-mediated pathway.	Cholesterol	4-15	interleukin 1 beta	Homo sapiens	45-53
20668705-8	2010	Silencing of the NLRP3 receptor, the crucial component in NLRP3 inflammasome, completely abolished crystal-induced IL-1beta secretion, thus identifying NLRP3 inflammasome as the cholesterol crystal-responsive element in macrophages.	Cholesterol	178-189	interleukin 1 beta	Homo sapiens	115-123
20668705-9	2010	The crystals were shown to induce leakage of the lysosomal protease cathepsin B into the cytoplasm and inhibition of this enzyme reduced cholesterol crystal-induced IL-1beta secretion, suggesting that NLRP3 inflammasome activation occurred via lysosomal destabilization.	Cholesterol	137-148	interleukin 1 beta	Homo sapiens	165-173
20661477-6	2010	Pharmacological inhibition of IL-1beta release from macrophages by vitamin D(3), a potent chemopreventive agent for colorectal cancer, restored the ability of TRAIL to induce apoptosis of tumor cells cultured with macrophages.	Vitamin D	67-76	interleukin 1 beta	Homo sapiens	30-38
20661477-10	2010	Vitamin D(3) halts this amplifying loop by interfering with the release of IL-1beta from macrophages.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	75-83
20979906-6	2010	RESULT: The change of the plasma levels of IL-6, IL-8, IL-1RA, TNF, IL-1beta in the two groups:in the parecoxib group the plasma levels of TNF and IL-1beta did not decreased significantly as compared with the control group (P &gt; 0.05).	parecoxib	102-111	interleukin 1 beta	Homo sapiens	68-76
20979906-6	2010	RESULT: The change of the plasma levels of IL-6, IL-8, IL-1RA, TNF, IL-1beta in the two groups:in the parecoxib group the plasma levels of TNF and IL-1beta did not decreased significantly as compared with the control group (P &gt; 0.05).	parecoxib	102-111	interleukin 1 beta	Homo sapiens	147-155
20630114-15	2010	Glc and GlcA reversed the effect of IL-1beta on the expression of AGG and SOX9, but other substances had no effect.	Glucose	0-3	interleukin 1 beta	Homo sapiens	36-44
20630114-15	2010	Glc and GlcA reversed the effect of IL-1beta on the expression of AGG and SOX9, but other substances had no effect.	Glucuronic Acid	8-12	interleukin 1 beta	Homo sapiens	36-44
20630114-16	2010	CONCLUSION: This study shows that glucosamine derivatives can alter anabolic and catabolic processes in HACs induced by IL-1beta.	Glucosamine	34-45	interleukin 1 beta	Homo sapiens	120-128
20411335-4	2010	IL-1beta also led to increased phosphorylation of eIF2alpha and all these events could be prevented by pretreatment with the JNK inhibitor, SP600125.	pyrazolanthrone	140-148	interleukin 1 beta	Homo sapiens	0-8
19717812-9	2010	In comparison, human lung fibroblasts treated with the cytokines, IL-1beta plus TNF-alpha, synthesize increased amounts of hyaluronan, but do not retain it or versican in the ECM, which, in turn, does not retain monocytes.	Hyaluronic Acid	123-133	interleukin 1 beta	Homo sapiens	66-74
20303074-5	2010	Moreover, we found that both IL-1beta and TNF-alpha induced a considerable shift from oligomannosidic glycans towards complex-type N-glycans.	oligomannosidic glycans	86-109	interleukin 1 beta	Homo sapiens	29-37
20303074-5	2010	Moreover, we found that both IL-1beta and TNF-alpha induced a considerable shift from oligomannosidic glycans towards complex-type N-glycans.	n-glycans	131-140	interleukin 1 beta	Homo sapiens	29-37
20411335-6	2010	IL-1beta stimulated JNK phosphorylation was observed even in the presence of the ER stress inhibitor, 4-phenyl butyrate and the decrease in cell viability was significantly prevented in the presence of the JNK inhibitor.	4-phenylbutyric acid	102-119	interleukin 1 beta	Homo sapiens	0-8
20369226-7	2010	Interference with IL-1beta signalling abolished palmitate-induced cytokine and chemokine expression but failed to prevent lipotoxic human islet cell death.	Palmitates	48-57	interleukin 1 beta	Homo sapiens	18-26
20590617-4	2010	EXPERIMENTAL APPROACH: Interleukin-1beta (IL-1beta)-stimulated human OA chondrocytes were treated with the p38MAPK inhibitors Birb 796, pamapimod, SB203580 and the new substance CBS-3868.	birb	126-130	interleukin 1 beta	Homo sapiens	23-40
20590617-4	2010	EXPERIMENTAL APPROACH: Interleukin-1beta (IL-1beta)-stimulated human OA chondrocytes were treated with the p38MAPK inhibitors Birb 796, pamapimod, SB203580 and the new substance CBS-3868.	birb	126-130	interleukin 1 beta	Homo sapiens	42-50
20590617-4	2010	EXPERIMENTAL APPROACH: Interleukin-1beta (IL-1beta)-stimulated human OA chondrocytes were treated with the p38MAPK inhibitors Birb 796, pamapimod, SB203580 and the new substance CBS-3868.	pamapimod	136-145	interleukin 1 beta	Homo sapiens	42-50
20590617-4	2010	EXPERIMENTAL APPROACH: Interleukin-1beta (IL-1beta)-stimulated human OA chondrocytes were treated with the p38MAPK inhibitors Birb 796, pamapimod, SB203580 and the new substance CBS-3868.	SB 203580	147-155	interleukin 1 beta	Homo sapiens	42-50
20590617-8	2010	Whereas SB203580 had a broad effect on chondrocytes, Birb 796 counteracted the IL-1beta effect more specifically.	doramapimod	53-61	interleukin 1 beta	Homo sapiens	79-87
20590617-9	2010	All p38MAPK inhibitors significantly inhibited the IL-1beta-induced gene expression of COX-2, mPGES1, iNOS, matrix metalloproteinase 13 (MMP13) and TNFRSF11B, as well as PGE(2) release.	Prostaglandins E	95-98	interleukin 1 beta	Homo sapiens	51-59
20228836-6	2010	At the light dose of 0.25-0.5 J/cm(2), Zn-BC-AM PDT-treated HK-1-EBV cells were found to produce a higher level of IL-1alpha and IL-1beta than the HK-1 cells.	zn-bc	39-44	interleukin 1 beta	Homo sapiens	129-137
20369226-9	2010	CONCLUSIONS/INTERPRETATION: Saturated-fatty-acid-induced NF-kappaB activation and endoplasmic reticulum stress may contribute to IL-1beta production and mild islet inflammation in type 2 diabetes.	Fatty Acids	28-48	interleukin 1 beta	Homo sapiens	129-137
20179743-2	2010	The shortage of mevalonate-derived intermediates, and in particular of geranylgeranyl pyrophosphate (GGPP), has been linked with the activation of caspase-1 and thereby with the production of IL-1beta, but the true concatenation of these two events has not been clarified yet.	Mevalonic Acid	16-26	interleukin 1 beta	Homo sapiens	192-200
20047993-4	2010	Indoxyl sulfate stimulated tumour necrosis factor-alpha, interleukin-6 (IL-6), and IL-1beta mRNA expression in THP-1 cells as quantified by RT-PCR.	Indican	0-15	interleukin 1 beta	Homo sapiens	83-91
20179743-2	2010	The shortage of mevalonate-derived intermediates, and in particular of geranylgeranyl pyrophosphate (GGPP), has been linked with the activation of caspase-1 and thereby with the production of IL-1beta, but the true concatenation of these two events has not been clarified yet.	geranylgeranyl pyrophosphate	71-99	interleukin 1 beta	Homo sapiens	192-200
20376628-13	2010	CONCLUSION: The results suggest that the CYP2C19 genotype contrary to MDR1 and IL-1B genotypes may have an impact on the efficacy of H. pylori eradication in peptic ulcer patients treated with pantoprazole in Polish Caucasian peptic ulcer patients administered pantoprazole, amoxicillin, and metronidazole.	Pantoprazole	193-205	interleukin 1 beta	Homo sapiens	79-84
20179743-2	2010	The shortage of mevalonate-derived intermediates, and in particular of geranylgeranyl pyrophosphate (GGPP), has been linked with the activation of caspase-1 and thereby with the production of IL-1beta, but the true concatenation of these two events has not been clarified yet.	geranylgeranyl pyrophosphate	101-105	interleukin 1 beta	Homo sapiens	192-200
19827118-7	2010	Besides, immortalized human epidermal keratinocyte (RHEK-1) epithelial cells could be enhanced to proliferate by IL-1alpha and IL-1beta determined by water-soluble tetrazolium salt (WST-1) assay.	Water	150-155	interleukin 1 beta	Homo sapiens	127-135
19827118-7	2010	Besides, immortalized human epidermal keratinocyte (RHEK-1) epithelial cells could be enhanced to proliferate by IL-1alpha and IL-1beta determined by water-soluble tetrazolium salt (WST-1) assay.	Tetrazolium Salts	164-180	interleukin 1 beta	Homo sapiens	127-135
20403460-2	2010	The aim of this study is to investigate the effect of myricetin on inflammatory cytokine/matrix metalloproteinase (MMP) production and mitogen-activated protein kinases (MAPKs) in IL-1beta-stimulated SW982 synovial cells.	myricetin	54-63	interleukin 1 beta	Homo sapiens	180-188
20141541-7	2010	Demethylation via 5-aza-2"-deoxycytodine led to the induction of IL-1beta expression in undifferentiated and differentiated cells, which could be increased after LPS stimulation.	5-aza-2"-deoxycytodine	18-40	interleukin 1 beta	Homo sapiens	65-73
20403460-0	2010	Myricetin inhibits IL-1beta-induced inflammatory mediators in SW982 human synovial sarcoma cells.	myricetin	0-9	interleukin 1 beta	Homo sapiens	19-27
20403460-3	2010	Myricetin significantly decreased IL-1beta-induced production of IL-6 and MMP-1 in synovial cells.	myricetin	0-9	interleukin 1 beta	Homo sapiens	34-42
20557833-8	2010	The addition of linezolid significantly reduced mRNA levels of IL-1beta, IL-6, IL-8 and TNF-alpha; (p &lt; 0.05) after 2 and 4 h. LPS stimulation also increased levels of IL-6, IL-8 and TNF-alpha between 100 and 1000-fold.	Linezolid	16-25	interleukin 1 beta	Homo sapiens	63-71
20108347-2	2010	Short-term treatment (2 days) with IL-1beta early in culture resulted in increased nodule number and size as well as calcium content in contrast to long-term treatment (6 days) in cultures assessed at 10-12 days.	Calcium	117-124	interleukin 1 beta	Homo sapiens	35-43
20108347-5	2010	Exogenous PGE(2) with IL-1beta enhanced this effect.	Prostaglandins E	10-13	interleukin 1 beta	Homo sapiens	22-30
20231161-4	2010	In addition, interleukin-1beta and estrone are able to enhance MRP1 gene expression and influence extracellular cAMP concentration.	Cyclic AMP	112-116	interleukin 1 beta	Homo sapiens	13-30
20417291-6	2010	RESULTS: Treatment of osteoarthritic chondrocytes with simvastatin decreased mRNA levels of MMP-13 and MMP-1 whether under basal conditions or during stimulation with IL-1beta.	Simvastatin	55-66	interleukin 1 beta	Homo sapiens	167-175
20306478-0	2010	Dietary phenolic acids attenuate multiple stages of protein glycation and high-glucose-stimulated proinflammatory IL-1beta activation by interfering with chromatin remodeling and transcription in monocytes.	phenolic acid	8-22	interleukin 1 beta	Homo sapiens	114-122
20306478-0	2010	Dietary phenolic acids attenuate multiple stages of protein glycation and high-glucose-stimulated proinflammatory IL-1beta activation by interfering with chromatin remodeling and transcription in monocytes.	Glucose	79-86	interleukin 1 beta	Homo sapiens	114-122
20306478-3	2010	Phenolic acids, especially methoxyphenolic acids, prevented increase in both levels of the interleukin-1beta (IL-1beta) and oxidative stress caused by HG.	phenolic acid	0-14	interleukin 1 beta	Homo sapiens	91-108
20306478-3	2010	Phenolic acids, especially methoxyphenolic acids, prevented increase in both levels of the interleukin-1beta (IL-1beta) and oxidative stress caused by HG.	phenolic acid	0-14	interleukin 1 beta	Homo sapiens	110-118
20306478-3	2010	Phenolic acids, especially methoxyphenolic acids, prevented increase in both levels of the interleukin-1beta (IL-1beta) and oxidative stress caused by HG.	methoxyphenolic acids	27-48	interleukin 1 beta	Homo sapiens	91-108
20306478-3	2010	Phenolic acids, especially methoxyphenolic acids, prevented increase in both levels of the interleukin-1beta (IL-1beta) and oxidative stress caused by HG.	methoxyphenolic acids	27-48	interleukin 1 beta	Homo sapiens	110-118
19777241-0	2010	Effects of (-)-epigallocatechin-3-gallate on cyclooxygenase 2, PGE(2), and IL-8 expression induced by IL-1beta in human synovial fibroblasts.	epigallocatechin gallate	11-41	interleukin 1 beta	Homo sapiens	102-110
19777241-0	2010	Effects of (-)-epigallocatechin-3-gallate on cyclooxygenase 2, PGE(2), and IL-8 expression induced by IL-1beta in human synovial fibroblasts.	Prostaglandins E	63-66	interleukin 1 beta	Homo sapiens	102-110
21055061-10	2010	Corresponding expression of NF-kappaB, IL-1beta, IL-8 and COX-2 decreased after the addition of Wedelolactone (relative values were 0.917 +- 0.188, 0.180 +- 0.008, 0, 0 respectively).	wedelolactone	96-109	interleukin 1 beta	Homo sapiens	39-47
20215705-7	2010	Granulins as conversion products derived from progranilin increased TNF-alpha and IL-1-beta expression and the effects were not suppressed by HDL.	progranilin	46-57	interleukin 1 beta	Homo sapiens	82-91
20979766-6	2010	We evaluated the relationship between serum levels of FFA and IL-1beta, IL-6, TNFalpha, hsCRP as well as the renal function in 130 adult patients with CKD, stratified according to the GFR (based on the National Kidney Foundation/Kidney Dialysis Outcomes Quality Initiatives) and in 58 hemodialytic (HD) patients.	Fatty Acids, Nonesterified	54-57	interleukin 1 beta	Homo sapiens	62-70
20581349-4	2010	The expression of cytokines (notably interleukin 1beta [IL-1beta], IL-6, IL-8, and tumor necrosis factor alpha [TNF-alpha]) by either the fetal or maternal tissues has been demonstrated to upregulate the activity of a number of uterine and cervical factors (eg, prostaglandin hormones and their receptors, matrix metalloproteinases, vascular endothelial growth factor [VEGF]), leading to premature initiation of the parturition process.	Prostaglandins	262-275	interleukin 1 beta	Homo sapiens	37-54
19777241-5	2010	COX-2 upregulation in synovial fibroblasts induced by IL-1beta was significantly suppressed by EGCG in a dose-dependent manner.	epigallocatechin gallate	95-99	interleukin 1 beta	Homo sapiens	54-62
20361957-9	2010	We found that among screened phytoestrogens, bavachin could potently decrease IL-1 beta-induced nuclear factor-kappa B (NF-kappaB) but not activator protein-1 (AP-1) DNA-binding activity.	bavachin	45-53	interleukin 1 beta	Homo sapiens	78-87
20361957-11	2010	Furthermore, bavachin inhibited IL-1 beta-induced chemokine production that resulted in reduced migration of THP-1 monocytic cells.	bavachin	13-21	interleukin 1 beta	Homo sapiens	32-41
20361957-12	2010	Our results suggest that through decreasing IL-1 beta-induced activation of IKK-I kappaB alpha-NF-kappaB signaling pathway, bavachin potentially protects cartilage from inflammation-mediated damage in joints of osteoarthritis patients.	bavachin	124-132	interleukin 1 beta	Homo sapiens	44-53
20441516-3	2010	Albendazole treatment, compared with placebo, was associated with significantly decreased plasma interleukin (IL) 10 levels (P = .01)ot associated with significant changes in levels of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12p70, IL-13, interferon gamma, tumor necrosis factor alpha, or thymic stromal lymphopoietin.	Albendazole	0-11	interleukin 1 beta	Homo sapiens	185-193
19777241-6	2010	PGE(2) and IL-8 secretion was also induced by IL-1beta stimulation and significantly suppressed by EGCG.	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	46-54
19777241-8	2010	EGCG may inhibit the expression of inflammatory mediators, such as COX-2, PGE(2), and IL-8, induced by IL-1beta in human synovial fibroblasts.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	103-111
19777241-8	2010	EGCG may inhibit the expression of inflammatory mediators, such as COX-2, PGE(2), and IL-8, induced by IL-1beta in human synovial fibroblasts.	Prostaglandins E	74-77	interleukin 1 beta	Homo sapiens	103-111
19809821-0	2010	Regulation of TNFalpha and IL1beta in rheumatoid arthritis synovial fibroblasts by leukotriene B4.	Leukotriene B4	83-97	interleukin 1 beta	Homo sapiens	27-34
19809821-6	2010	Furthermore, we examined the effects of leukotrienes synthesis inhibitors, MK886 and bestatin, on mRNA and protein levels of TNFalpha and IL1beta in RASF.	Leukotrienes	40-52	interleukin 1 beta	Homo sapiens	138-145
19809821-6	2010	Furthermore, we examined the effects of leukotrienes synthesis inhibitors, MK886 and bestatin, on mRNA and protein levels of TNFalpha and IL1beta in RASF.	MK-886	75-80	interleukin 1 beta	Homo sapiens	138-145
20338162-9	2010	As results, after Corilagin intervention, the release of TNF-alpha, IL-1beta and NO from HSV-stimulated migroglia cells was significantly inhibited.	corilagin	18-27	interleukin 1 beta	Homo sapiens	68-76
20424162-5	2010	In addition, prolonged exposure to high glucose further increases IL-1beta-triggered CHOP expression.	Glucose	40-47	interleukin 1 beta	Homo sapiens	66-74
19844976-6	2010	Furthermore, cobalt, molybdenum ions, and Co-Cr-Mo alloy particles similarly induce elevated secretion of IL-1beta, TNFalpha, and IL-6.	Cobalt	13-19	interleukin 1 beta	Homo sapiens	106-114
19844976-6	2010	Furthermore, cobalt, molybdenum ions, and Co-Cr-Mo alloy particles similarly induce elevated secretion of IL-1beta, TNFalpha, and IL-6.	Molybdenum	21-31	interleukin 1 beta	Homo sapiens	106-114
19844976-6	2010	Furthermore, cobalt, molybdenum ions, and Co-Cr-Mo alloy particles similarly induce elevated secretion of IL-1beta, TNFalpha, and IL-6.	co-cr-mo	42-50	interleukin 1 beta	Homo sapiens	106-114
20348217-4	2010	Using radioactive assay, we demonstrated that sirolimus inhibited the increase of interleukin-1beta (IL-1beta)-induced cholesterol synthesis in VSMCs.	Sirolimus	46-55	interleukin 1 beta	Homo sapiens	82-99
20651334-5	2010	The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1.	alpha-terpineol	27-36	interleukin 1 beta	Homo sapiens	282-291
20413686-6	2010	We demonstrate for the first time that normal primary skeletal muscle cells are capable of secreting IL-1beta in response to combined treatment with lipopolysaccharide and the P2X7 receptor agonist, benzylated ATP, suggesting that not only immune cells but also muscle cells can actively participate in inflammasome formation.	Adenosine Triphosphate	210-213	interleukin 1 beta	Homo sapiens	101-109
20348217-4	2010	Using radioactive assay, we demonstrated that sirolimus inhibited the increase of interleukin-1beta (IL-1beta)-induced cholesterol synthesis in VSMCs.	Sirolimus	46-55	interleukin 1 beta	Homo sapiens	101-109
20413686-7	2010	In addition, we show that dysferlin-deficient primary muscle cells express toll-like receptors (TLRs; TLR-2 and TLR-4) and can efficiently produce IL-1beta in response to lipopolysaccharide and benzylated ATP.	Adenosine Triphosphate	205-208	interleukin 1 beta	Homo sapiens	147-155
20348217-4	2010	Using radioactive assay, we demonstrated that sirolimus inhibited the increase of interleukin-1beta (IL-1beta)-induced cholesterol synthesis in VSMCs.	Cholesterol	119-130	interleukin 1 beta	Homo sapiens	82-99
20348217-4	2010	Using radioactive assay, we demonstrated that sirolimus inhibited the increase of interleukin-1beta (IL-1beta)-induced cholesterol synthesis in VSMCs.	Cholesterol	119-130	interleukin 1 beta	Homo sapiens	101-109
20348217-4	2010	Using radioactive assay, we demonstrated that sirolimus inhibited the increase of interleukin-1beta (IL-1beta)-induced cholesterol synthesis in VSMCs.	vsmcs	144-149	interleukin 1 beta	Homo sapiens	82-99
20348217-4	2010	Using radioactive assay, we demonstrated that sirolimus inhibited the increase of interleukin-1beta (IL-1beta)-induced cholesterol synthesis in VSMCs.	vsmcs	144-149	interleukin 1 beta	Homo sapiens	101-109
20348217-5	2010	Further studies showed that sirolimus inhibited both the HMGR gene and protein expression in VSMCs treated with or without IL-1beta.	Sirolimus	28-37	interleukin 1 beta	Homo sapiens	123-131
20207200-5	2010	Moreover, the inflammatory cytokines, IFN-gamma and IL-1beta, produced by hPBMCs upon activation notably upregulated the expression of cyclooxygenase-2 (COX-2) and the production of PGE(2) by hUC-MSCs.	Prostaglandins E	182-185	interleukin 1 beta	Homo sapiens	52-60
20221783-1	2010	Activation of peroxisome proliferator-activated receptor (PPAR) delta by GW501516, a specific PPARdelta ligand, significantly inhibited interleukin (IL)-1beta-induced proliferation and migration of vascular smooth muscle cells (VSMCs).	GW 501516	73-81	interleukin 1 beta	Homo sapiens	136-158
20221783-4	2010	Inhibition of cell migration by GW501516 was associated with the down-regulation of matrix metalloproteinase (MMP)-2 and MMP-9 in IL-1beta-treated VSMCs.	GW 501516	32-40	interleukin 1 beta	Homo sapiens	130-138
20221783-5	2010	Inhibition of extracellular signal-regulated kinase significantly reduced the GW501516-mediated inhibition of IL-1beta-stimulated VSMC proliferation.	GW 501516	78-86	interleukin 1 beta	Homo sapiens	110-118
20164440-5	2010	Treatment of HuF cells with the embryonic stimulus cytokine interleukin 1 beta in the presence of steroid hormones (estradiol-17 beta and medroxyprogesterone acetate) for 13 days did not cause any apparent TAZ mRNA changes but resulted in a significant TAZ protein decline (approximately 62%) in total cell lysates.	Steroids	98-114	interleukin 1 beta	Homo sapiens	60-78
20164440-5	2010	Treatment of HuF cells with the embryonic stimulus cytokine interleukin 1 beta in the presence of steroid hormones (estradiol-17 beta and medroxyprogesterone acetate) for 13 days did not cause any apparent TAZ mRNA changes but resulted in a significant TAZ protein decline (approximately 62%) in total cell lysates.	Estradiol	116-133	interleukin 1 beta	Homo sapiens	60-78
20164440-5	2010	Treatment of HuF cells with the embryonic stimulus cytokine interleukin 1 beta in the presence of steroid hormones (estradiol-17 beta and medroxyprogesterone acetate) for 13 days did not cause any apparent TAZ mRNA changes but resulted in a significant TAZ protein decline (approximately 62%) in total cell lysates.	Medroxyprogesterone Acetate	138-165	interleukin 1 beta	Homo sapiens	60-78
20207050-2	2010	Further, pro-inflammatory cytokines such as TNF-alpha and IL-1beta and pro-inflammatory mediator such as Nitric Oxide (NO) besides inducible Nitric Oxide Synthase (iNOS) were inhibited by the copper complexes.	Copper	192-198	interleukin 1 beta	Homo sapiens	58-66
20445007-7	2010	PAM stimulation also induced IL-1beta, IL-6, and IL-8.	pam	0-3	interleukin 1 beta	Homo sapiens	29-37
20445007-10	2010	In contrast, delayed DEX addition significantly suppressed PAM-induced IL-1beta, IL-6, or IL-8 and also suppressed LPS-induced IL-1beta and IL-8.	Dexamethasone	21-24	interleukin 1 beta	Homo sapiens	71-79
20445007-10	2010	In contrast, delayed DEX addition significantly suppressed PAM-induced IL-1beta, IL-6, or IL-8 and also suppressed LPS-induced IL-1beta and IL-8.	Dexamethasone	21-24	interleukin 1 beta	Homo sapiens	127-135
20445007-10	2010	In contrast, delayed DEX addition significantly suppressed PAM-induced IL-1beta, IL-6, or IL-8 and also suppressed LPS-induced IL-1beta and IL-8.	pam	59-62	interleukin 1 beta	Homo sapiens	71-79
20053983-7	2010	Pirfenidone was more effective than dexamethasone in inhibiting IL-1beta-induced increases in TIMP-1, reducing TIMP-1 levels to less than those in untreated controls at a minimal concentration (5 mM).	pirfenidone	0-11	interleukin 1 beta	Homo sapiens	64-72
20304105-1	2010	The inhibition of mevalonate pathway through genetic defects (mevalonate kinase deficiency, MKD) or pharmacologic drugs (aminobisphosphonates) causes a shortage of intermediate compounds and, in particular, of geranylgeranyl-pyrophosphate (GGPP) associated to the activation of caspase-1 and IL-1beta release.	Mevalonic Acid	18-28	interleukin 1 beta	Homo sapiens	292-300
20304105-1	2010	The inhibition of mevalonate pathway through genetic defects (mevalonate kinase deficiency, MKD) or pharmacologic drugs (aminobisphosphonates) causes a shortage of intermediate compounds and, in particular, of geranylgeranyl-pyrophosphate (GGPP) associated to the activation of caspase-1 and IL-1beta release.	aminobisphosphonates	121-141	interleukin 1 beta	Homo sapiens	292-300
20304105-1	2010	The inhibition of mevalonate pathway through genetic defects (mevalonate kinase deficiency, MKD) or pharmacologic drugs (aminobisphosphonates) causes a shortage of intermediate compounds and, in particular, of geranylgeranyl-pyrophosphate (GGPP) associated to the activation of caspase-1 and IL-1beta release.	geranylgeranyl pyrophosphate	210-238	interleukin 1 beta	Homo sapiens	292-300
20053983-7	2010	Pirfenidone was more effective than dexamethasone in inhibiting IL-1beta-induced increases in TIMP-1, reducing TIMP-1 levels to less than those in untreated controls at a minimal concentration (5 mM).	Dexamethasone	36-49	interleukin 1 beta	Homo sapiens	64-72
20512083-9	2010	RESULTS: ET-1 secretion of EGCs could be stimulated by IL-1 beta and TNFalpha in a time and dose-dependent manner, whereas IL-4 and interferon-gamma showed no effect on ET-1 production.	gallocatechol	27-31	interleukin 1 beta	Homo sapiens	55-64
21179939-7	2010	The long nanotubes (NT1) caused increased release of the proinflammatory cytokine IL-1beta, an effect which was diminished by the antioxidant trolox, suggesting a role of oxidative stress in the upregulation of this cytokine.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	142-148	interleukin 1 beta	Homo sapiens	82-90
20421639-4	2010	We show that beta-glucans activate the transcription of the proinflammatory cytokine IL-1beta through a dectin-1-dependent pathway in human macrophages.	beta-Glucans	13-25	interleukin 1 beta	Homo sapiens	85-93
20421639-5	2010	Moreover, dectin-1 receptor associated Syk tyrosine kinase was essential for beta-glucan induced IL-1beta mRNA expression.	beta-Glucans	77-88	interleukin 1 beta	Homo sapiens	97-105
20421639-6	2010	In contrast to LPS, beta-glucans also strongly activated the secretion of IL-1beta.	beta-Glucans	20-32	interleukin 1 beta	Homo sapiens	74-82
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	beta-Glucans	5-16	interleukin 1 beta	Homo sapiens	27-35
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	beta-Glucans	5-16	interleukin 1 beta	Homo sapiens	180-188
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	Cytochalasin D	61-75	interleukin 1 beta	Homo sapiens	27-35
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	Cytochalasin D	61-75	interleukin 1 beta	Homo sapiens	180-188
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	beta-Glucans	151-163	interleukin 1 beta	Homo sapiens	27-35
20421639-7	2010	This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages.	beta-Glucans	151-163	interleukin 1 beta	Homo sapiens	180-188
20421639-8	2010	RNA interference-mediated gene knockdown experiments demonstrated that cytoplasmic NLRP3 inflammasome is essential for beta-glucan-induced IL-1beta secretion.	beta-Glucans	119-130	interleukin 1 beta	Homo sapiens	139-147
19428234-10	2010	Moreover, tryptophan reduced the expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-12p40, IL-1beta and IL-17, as well as IL-8 and intracellular adhesion molecule-1, and resulted in increased expression of apoptosis initiators caspase-8 and Bax.	Tryptophan	10-20	interleukin 1 beta	Homo sapiens	161-169
20631892-3	2010	Treatment of astrocytes with bezafibrate and fenofibrate (0, 5, and 10 microM) reduced the IFNgamma and IL-1beta-induced cell proliferation in a dose-dependent manner.	Bezafibrate	29-40	interleukin 1 beta	Homo sapiens	104-112
20631892-3	2010	Treatment of astrocytes with bezafibrate and fenofibrate (0, 5, and 10 microM) reduced the IFNgamma and IL-1beta-induced cell proliferation in a dose-dependent manner.	Fenofibrate	45-56	interleukin 1 beta	Homo sapiens	104-112
20421639-11	2010	In conclusion, our results show that beta-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1beta gene transcription and IL-1beta secretion in human macrophages, respectively.	beta-Glucans	37-49	interleukin 1 beta	Homo sapiens	145-153
20421639-11	2010	In conclusion, our results show that beta-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1beta gene transcription and IL-1beta secretion in human macrophages, respectively.	beta-Glucans	37-49	interleukin 1 beta	Homo sapiens	177-185
20069635-4	2010	Human knee articular cartilage explants were sorted according to the degree of OA and treated for 10 days with tetracycline derivatives in the presence of interleukin-1 (IL-1beta).	Tetracycline	111-123	interleukin 1 beta	Homo sapiens	170-178
20512083-4	2010	MATERIAL/METHODS: Cultured EGCs were treated with interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNFalpha), IL-4, interferon-gamma, and ET-1.	gallocatechol	27-31	interleukin 1 beta	Homo sapiens	50-68
20512083-4	2010	MATERIAL/METHODS: Cultured EGCs were treated with interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNFalpha), IL-4, interferon-gamma, and ET-1.	gallocatechol	27-31	interleukin 1 beta	Homo sapiens	70-79
20512083-12	2010	Incubation of cells with IL-1 beta, TNFalpha, and ET-1 led to a significant increase of GFAP in EGCs.	gallocatechol	96-100	interleukin 1 beta	Homo sapiens	25-34
20607065-6	2010	The cortisol concentration and serum levels of IL-1beta and IL-6 after Oligonol intake were significantly decreased compared to before treatment (P &lt; 0.01, respectively).	oligonol	71-79	interleukin 1 beta	Homo sapiens	47-55
20092674-7	2010	Furthermore, plasma interleukin-1beta also positively correlated with plasma nitrite/nitrate (p=0.003).	Nitrites	77-84	interleukin 1 beta	Homo sapiens	20-37
20092674-7	2010	Furthermore, plasma interleukin-1beta also positively correlated with plasma nitrite/nitrate (p=0.003).	Nitrates	85-92	interleukin 1 beta	Homo sapiens	20-37
20307255-2	2010	Thalidomide and IMiDs inhibit the cytokines tumour necrosis factor-alpha (TNF-alpha), interleukins (IL) 1-beta, 6, 12, and granulocyte macrophage-colony stimulating factor (GM-CSF).	Thalidomide	0-11	interleukin 1 beta	Homo sapiens	86-110
20527063-11	2010	The reduction of IL-1 beta in the wound exudate supports a mechanism that may involve manipulation of the dynamics of endogenous IL-1 beta in the wound bed by means of a pulsed electromagnetic field effect on nitric oxide signaling, which could impact the speed and quality of wound repair.	Nitric Oxide	209-221	interleukin 1 beta	Homo sapiens	17-26
20527063-11	2010	The reduction of IL-1 beta in the wound exudate supports a mechanism that may involve manipulation of the dynamics of endogenous IL-1 beta in the wound bed by means of a pulsed electromagnetic field effect on nitric oxide signaling, which could impact the speed and quality of wound repair.	Nitric Oxide	209-221	interleukin 1 beta	Homo sapiens	129-138
19697035-7	2010	Hypoxia (2% O(2)) decreased IL-1beta-stimulated production of PGE(2), even though it increased the expression of mRNA and protein of COX-2.	Prostaglandins E	62-65	interleukin 1 beta	Homo sapiens	28-36
19697035-0	2010	Differential effect of IL-1beta and TNFalpha on the production of IL-6, IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages.	Dinoprostone	81-85	interleukin 1 beta	Homo sapiens	23-31
19697035-5	2010	In FLSs, PGE(2) production increased only in response to IL-1beta; and no effect was observed in THP-1 cells and TNF-alpha-stimulated FLSs.	Prostaglandins E	9-13	interleukin 1 beta	Homo sapiens	57-65
19697035-7	2010	Hypoxia (2% O(2)) decreased IL-1beta-stimulated production of PGE(2), even though it increased the expression of mRNA and protein of COX-2.	o(2)	12-16	interleukin 1 beta	Homo sapiens	28-36
20480520-7	2010	Butyrate also up-regulated IL-1beta-induced IL-32alpha mRNA expression.	Butyrates	0-8	interleukin 1 beta	Homo sapiens	27-35
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	tripterygium glycosides	62-85	interleukin 1 beta	Homo sapiens	178-195
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	tripterygium glycosides	62-85	interleukin 1 beta	Homo sapiens	197-205
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	interleukin 1 beta	Homo sapiens	178-195
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	interleukin 1 beta	Homo sapiens	197-205
20153342-6	2010	Our conclusion is based on the measurement of nitric oxide and proinflammatory mediators using purified microglia cultures and microglia cell lines: donepezil attenuated microglial production of nitric oxide and tumor necrosis factor (TNF)-alpha, and suppressed the gene expression of inducible nitric oxide synthase, interleukin-1 beta, and TNF-alpha.	Donepezil	149-158	interleukin 1 beta	Homo sapiens	318-336
20480520-9	2010	Like butyrate, trichostatin A, a histone deacetylase inhibitor, also enhanced IL-1beta-induced IL-32alpha mRNA expression.	Butyrates	5-13	interleukin 1 beta	Homo sapiens	78-86
20480520-9	2010	Like butyrate, trichostatin A, a histone deacetylase inhibitor, also enhanced IL-1beta-induced IL-32alpha mRNA expression.	trichostatin A	15-29	interleukin 1 beta	Homo sapiens	78-86
19769459-4	2010	For the first time, we show that GYY4137 significantly and concentration-dependently inhibits LPS-induced release of proinflammatory mediators such as IL-1beta, IL-6, TNF-alpha, nitric oxide (*NO), and PGE(2) but increased the synthesis of the antiinflammatory chemokine IL-10 through NF-kappaB/ATF-2/HSP-27-dependent pathways.	GYY 4137	33-40	interleukin 1 beta	Homo sapiens	151-159
20482831-9	2010	RESULTS: Pretreatment with DMF decreased synthesis of the proinflammatory mediators iNOS, TNF-alpha, IL-1beta and IL-6 at the RNA level in activated microglia and astrocytes in vitro, associated with a decrease in ERK phosphorylation in microglia.	Dimethyl Fumarate	27-30	interleukin 1 beta	Homo sapiens	101-109
20482831-0	2010	Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation.	Dimethyl Fumarate	0-16	interleukin 1 beta	Homo sapiens	111-119
20309583-8	2010	The expressions of alpha 7 nAChR and IL-1 beta were significantly increased by nicotine administration, whereas alpha-Btx treatment partially suppressed these effects.	Nicotine	79-87	interleukin 1 beta	Homo sapiens	37-46
19769459-5	2010	In contrast, NaHS elicited a biphasic effect on proinflammatory mediators and, at high concentrations, increased the synthesis of IL-1beta, IL-6, NO, PGE(2) and TNF-alpha.	sodium bisulfide	13-17	interleukin 1 beta	Homo sapiens	130-138
20231290-5	2010	PTX increased the expression of IL-1beta and AT1R through NF-kappaB, and a small GTP-binding protein, Rac, mediated PTX-induced NF-kappaB activation through NADPH oxidase-dependent production of reactive oxygen species.	Guanosine Triphosphate	81-84	interleukin 1 beta	Homo sapiens	32-40
20231290-5	2010	PTX increased the expression of IL-1beta and AT1R through NF-kappaB, and a small GTP-binding protein, Rac, mediated PTX-induced NF-kappaB activation through NADPH oxidase-dependent production of reactive oxygen species.	Reactive Oxygen Species	195-218	interleukin 1 beta	Homo sapiens	32-40
20346081-8	2010	Fenofibrate, at 5 microg/ml, decreased the viability of HRECs stimulated by IL-1beta and VEGF without hyalocytes but could not decrease the viability of HRECs cocultured with hyalocytes.	Fenofibrate	0-11	interleukin 1 beta	Homo sapiens	76-84
20346081-9	2010	Dexamethasone, at 50 microg/ml, decreased the viability of HRECs stimulated by IL-1alpha, IL-1beta, IL-6 and VEGF without hyalocytes but could not decrease the viability of HRECs cocultured.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	90-98
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Albuterol	64-74	interleukin 1 beta	Homo sapiens	170-178
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Albuterol	64-74	interleukin 1 beta	Homo sapiens	183-191
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Salmeterol Xinafoate	76-86	interleukin 1 beta	Homo sapiens	170-178
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Salmeterol Xinafoate	76-86	interleukin 1 beta	Homo sapiens	183-191
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Formoterol Fumarate	88-98	interleukin 1 beta	Homo sapiens	170-178
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Formoterol Fumarate	88-98	interleukin 1 beta	Homo sapiens	183-191
20067961-7	2010	CONCLUSIONS: Although both glucose and cream induce NF-kappaB binding and an increase in the expression of SOCS3, TNF-alpha, and IL-1beta in MNCs, only cream caused an increase in LPS concentration and TLR-4 expression.	Glucose	27-34	interleukin 1 beta	Homo sapiens	129-137
20200188-1	2010	The objective of this study was to investigate the effects of glucose-based peritoneal dialysis (PD) fluids and icodextrin-based PD fluids on the expression of Toll-like receptor 2 (TLR2)/TLR4 and subsequent ligand-induced mitogen-activated protein kinase (MAPK) and NF-kappaB signaling and tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expression in human peritoneal mesothelial cells (HPMCs).	Glucose	62-69	interleukin 1 beta	Homo sapiens	335-352
20200188-1	2010	The objective of this study was to investigate the effects of glucose-based peritoneal dialysis (PD) fluids and icodextrin-based PD fluids on the expression of Toll-like receptor 2 (TLR2)/TLR4 and subsequent ligand-induced mitogen-activated protein kinase (MAPK) and NF-kappaB signaling and tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expression in human peritoneal mesothelial cells (HPMCs).	Glucose	62-69	interleukin 1 beta	Homo sapiens	354-362
20200188-1	2010	The objective of this study was to investigate the effects of glucose-based peritoneal dialysis (PD) fluids and icodextrin-based PD fluids on the expression of Toll-like receptor 2 (TLR2)/TLR4 and subsequent ligand-induced mitogen-activated protein kinase (MAPK) and NF-kappaB signaling and tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expression in human peritoneal mesothelial cells (HPMCs).	Icodextrin	112-122	interleukin 1 beta	Homo sapiens	335-352
20200188-1	2010	The objective of this study was to investigate the effects of glucose-based peritoneal dialysis (PD) fluids and icodextrin-based PD fluids on the expression of Toll-like receptor 2 (TLR2)/TLR4 and subsequent ligand-induced mitogen-activated protein kinase (MAPK) and NF-kappaB signaling and tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expression in human peritoneal mesothelial cells (HPMCs).	Icodextrin	112-122	interleukin 1 beta	Homo sapiens	354-362
20188213-0	2010	Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	45-53
20507366-1	2010	AIM: We sought to determine whether triclosan (2,4,4"-trichloro-2"-hydroxydiphenylether), an extensively used anti-plaque agent with broad-spectrum anti-microbial activity, with reported anti-inflammatory effects via inhibition of prostaglandin E2 and interleukin 1 (IL-1)beta, could also more broadly suppress multiple inflammatory gene pathways responsible for the pathogenesis of gingivitis and periodontitis.	Triclosan	47-87	interleukin 1 beta	Homo sapiens	267-276
20082309-5	2010	Higher concentrations of IL-1beta-induced COX-2 mRNA and protein associated with an increase in PGE(2) and cAMP, and all of these parameters were potentiated by bFGF.	Prostaglandins E	96-99	interleukin 1 beta	Homo sapiens	25-33
20082309-5	2010	Higher concentrations of IL-1beta-induced COX-2 mRNA and protein associated with an increase in PGE(2) and cAMP, and all of these parameters were potentiated by bFGF.	Cyclic AMP	107-111	interleukin 1 beta	Homo sapiens	25-33
20082309-9	2010	The antiproliferative effect of IL-1beta is likely attributed to the induction of COX-2, which is further potentiated by bFGF, and the subsequent generation of PGE(2) and cAMP.	Prostaglandins E	160-163	interleukin 1 beta	Homo sapiens	32-40
20082309-9	2010	The antiproliferative effect of IL-1beta is likely attributed to the induction of COX-2, which is further potentiated by bFGF, and the subsequent generation of PGE(2) and cAMP.	Cyclic AMP	171-175	interleukin 1 beta	Homo sapiens	32-40
20507366-1	2010	AIM: We sought to determine whether triclosan (2,4,4"-trichloro-2"-hydroxydiphenylether), an extensively used anti-plaque agent with broad-spectrum anti-microbial activity, with reported anti-inflammatory effects via inhibition of prostaglandin E2 and interleukin 1 (IL-1)beta, could also more broadly suppress multiple inflammatory gene pathways responsible for the pathogenesis of gingivitis and periodontitis.	Triclosan	36-45	interleukin 1 beta	Homo sapiens	267-276
19427777-5	2010	Interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha secretion from EPA, DHA and control cells were differentially limited by LPS concentration.	Eicosapentaenoic Acid	76-79	interleukin 1 beta	Homo sapiens	0-22
20586862-7	2010	In a recent investigation, carriage of the IL-1beta-511 T allele was significantly associated with peptic ulcer among low-dose aspirin users.	Aspirin	127-134	interleukin 1 beta	Homo sapiens	43-51
20386470-7	2010	LPS stimulation of DCs induced IL-10, IL-12p70, TNFalpha and IL-1beta secretion, and taxol pretreatment modified this response by down-regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion.	Paclitaxel	85-90	interleukin 1 beta	Homo sapiens	146-154
19427777-5	2010	Interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha secretion from EPA, DHA and control cells were differentially limited by LPS concentration.	Dihydroalprenolol	81-84	interleukin 1 beta	Homo sapiens	0-22
20370890-8	2010	RESULTS: Our data suggest that DEA-CLA, product of the esterification between the CLA and batyl alcohol, present beneficial effects on adipocytes close to observed and described for CLA (i.e. decrease of IL-1beta) and no adverse effects as observed for batyl alcohol (i.e. decrease of IL-10).	dea-cla	31-38	interleukin 1 beta	Homo sapiens	204-212
20019678-7	2010	Fasting glucose related to VAT expression of TNFalpha, MIP, serum amyloid A (SAA), IL-1alpha, IL-1beta, IL-8, and IL-8 receptor.	Glucose	8-15	interleukin 1 beta	Homo sapiens	94-102
20384487-7	2010	IL-1beta slightly induced cAMP production, but induced HAS mRNA expression of all three isoforms and HA secretion.	Cyclic AMP	26-30	interleukin 1 beta	Homo sapiens	0-8
20110250-11	2010	RESULTS: Induction of HO-1 by CoPP in the presence of IL-1beta decreased the expression of MMP-1 and -3, and MMP activity.	cobaltiprotoporphyrin	30-34	interleukin 1 beta	Homo sapiens	54-62
20386708-5	2010	Interestingly, the elevation of D-glucose levels potentiated ICAM-1 and VCAM-1 expression and leukocyte adhesion induced by a pro-inflammatory stimulus, such as interleukin (IL)-1beta (5 ng/mL).	Glucose	32-41	interleukin 1 beta	Homo sapiens	161-183
20386708-6	2010	In HUVEC, high D-glucose augmented the activation of extracellular signal-regulated kinase 1/2 (ERK 1/2) and nuclear transcription factor-kappaB (NF-kappaB) elicited by IL-1beta, measured by Western blot and electromobility shift assay (EMSA), respectively, but had no effect by itself.	Glucose	15-24	interleukin 1 beta	Homo sapiens	169-177
20386708-9	2010	In accordance with the in vitro data, the acute intraperitoneal injection of D-glucose increased leukocyte rolling flux, adhesion and migration, but only when IL-1beta was co-administered.	Glucose	77-86	interleukin 1 beta	Homo sapiens	159-167
20370890-8	2010	RESULTS: Our data suggest that DEA-CLA, product of the esterification between the CLA and batyl alcohol, present beneficial effects on adipocytes close to observed and described for CLA (i.e. decrease of IL-1beta) and no adverse effects as observed for batyl alcohol (i.e. decrease of IL-10).	Linoleic Acids, Conjugated	35-38	interleukin 1 beta	Homo sapiens	204-212
20069553-1	2010	Cytosolic phospholipase A(2) (cPLA(2)) plays a pivotal role in mediating agonist-induced arachidonic acid (AA) release for prostaglandin (PG) synthesis during inflammation triggered by IL-1beta.	Arachidonic Acid	89-105	interleukin 1 beta	Homo sapiens	185-193
20103743-9	2010	Conversely, in the presence of LPS or IL-1beta, increases in COX-2 were attenuated by cotreatment with DHT.	Dihydrotestosterone	103-106	interleukin 1 beta	Homo sapiens	38-46
19713204-6	2010	Glycomacropeptide (GMP) and G600 milk fat extract both inhibited interleukin-1beta (IL1beta) gene and protein expression in the THP-1 cell assay.	g600	28-32	interleukin 1 beta	Homo sapiens	65-82
19713204-6	2010	Glycomacropeptide (GMP) and G600 milk fat extract both inhibited interleukin-1beta (IL1beta) gene and protein expression in the THP-1 cell assay.	g600	28-32	interleukin 1 beta	Homo sapiens	84-91
19840967-8	2010	SD282 (10(-7) M), with dexamethasone (10( -6) M), caused a greater inhibition of release of IL-1beta, IL-6, macrophage inflammatory protein-1alpha and IL-10, than with dexamethasone alone in AMs from severe and non-severe asthma.	Dexamethasone	23-36	interleukin 1 beta	Homo sapiens	92-100
20138154-4	2010	Hirsutenone, dexamethasone, ERK inhibitor or Bay 11-7085 (an inhibitor of NF-kappaB activation) reduced the lipopolysaccharide-induced production of cytokines IL-1beta and IL-8, and the chemokine CCL17.	hirsutenone	0-11	interleukin 1 beta	Homo sapiens	159-167
20138154-4	2010	Hirsutenone, dexamethasone, ERK inhibitor or Bay 11-7085 (an inhibitor of NF-kappaB activation) reduced the lipopolysaccharide-induced production of cytokines IL-1beta and IL-8, and the chemokine CCL17.	Dexamethasone	13-26	interleukin 1 beta	Homo sapiens	159-167
20138154-4	2010	Hirsutenone, dexamethasone, ERK inhibitor or Bay 11-7085 (an inhibitor of NF-kappaB activation) reduced the lipopolysaccharide-induced production of cytokines IL-1beta and IL-8, and the chemokine CCL17.	BAY 11-7085	45-56	interleukin 1 beta	Homo sapiens	159-167
19569215-4	2010	However, endotoxin-exposed PCU particles induced significantly less TNFalpha and IL-1beta than endotoxin-exposed xUHMWPE particles.	PCU	27-30	interleukin 1 beta	Homo sapiens	81-89
20069553-4	2010	IL-1beta-induced cPLA(2) expression was also inhibited by pretreatment with a NF-kappaB inhibitor, helenalin or transfection with siRNA of NIK, IKKalpha, or IKKbeta.	helenalin	99-108	interleukin 1 beta	Homo sapiens	0-8
20019361-12	2010	IL-1beta and TNFalpha showed a significant correlation with 8-OHdG-stained cell counts.	8-ohdg	60-66	interleukin 1 beta	Homo sapiens	0-8
20069553-8	2010	These results suggest that in HTSMCs, activation of MAPKs, NF-kappaB, and p300 are essential for IL-1beta-induced cPLA(2) expression and PGE(2) secretion.	Prostaglandins E	137-140	interleukin 1 beta	Homo sapiens	97-105
20069553-1	2010	Cytosolic phospholipase A(2) (cPLA(2)) plays a pivotal role in mediating agonist-induced arachidonic acid (AA) release for prostaglandin (PG) synthesis during inflammation triggered by IL-1beta.	Prostaglandins	123-136	interleukin 1 beta	Homo sapiens	185-193
20069553-2	2010	However, the mechanisms underlying IL-1beta-induced cPLA(2) expression and PGE(2) synthesis in human tracheal smooth muscle cells (HTSMCs) remain unknown.	Prostaglandins E	75-78	interleukin 1 beta	Homo sapiens	35-43
20069553-3	2010	IL-1beta-induced cPLA(2) protein and mRNA expression, PGE(2) production, or phosphorylation of p42/p44 MAPK, p38 MAPK, and JNK1/2, which was attenuated by pretreatment with the inhibitors of MEK1/2 (U0126), p38 MAPK (SB202190), and JNK1/2 (SP600125) or transfection with siRNAs of MEK1, p42, p38, and JNK2.	Prostaglandins E	54-57	interleukin 1 beta	Homo sapiens	0-8
20069553-3	2010	IL-1beta-induced cPLA(2) protein and mRNA expression, PGE(2) production, or phosphorylation of p42/p44 MAPK, p38 MAPK, and JNK1/2, which was attenuated by pretreatment with the inhibitors of MEK1/2 (U0126), p38 MAPK (SB202190), and JNK1/2 (SP600125) or transfection with siRNAs of MEK1, p42, p38, and JNK2.	pyrazolanthrone	240-248	interleukin 1 beta	Homo sapiens	0-8
20194723-8	2010	Taken together, our results suggest that BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta, thus contributing to angiogenesis.	reactive	51-59	interleukin 1 beta	Homo sapiens	207-215
20194723-8	2010	Taken together, our results suggest that BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta, thus contributing to angiogenesis.	oxygen species	60-74	interleukin 1 beta	Homo sapiens	207-215
20060906-0	2010	Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1beta.	N-Methylaspartate	33-37	interleukin 1 beta	Homo sapiens	93-110
20026404-6	2010	After stimulation of MC with the cytokines TNF-alpha, IL-1beta and IFN-gamma alone or in combination to simulate a proinflammatory milieu as would occur during immune-mediated inflammatory disease, an upregulation of TLR3 is seen.	Methylcholanthrene	21-23	interleukin 1 beta	Homo sapiens	54-62
20060906-2	2010	IL-1beta inhibits N-methyl-d-aspartate (NMDA)-induced outward currents (I(NMDA-OUT)) through IL-1 type I receptor (IL-1RI) in hippocampal CA1 neurons (Zhang, R., Yamada, J., Hayashi, Y., Wu, Z, Koyama, S., Nakanishi, H., 2008.	N-Methylaspartate	40-44	interleukin 1 beta	Homo sapiens	0-8
20060906-2	2010	IL-1beta inhibits N-methyl-d-aspartate (NMDA)-induced outward currents (I(NMDA-OUT)) through IL-1 type I receptor (IL-1RI) in hippocampal CA1 neurons (Zhang, R., Yamada, J., Hayashi, Y., Wu, Z, Koyama, S., Nakanishi, H., 2008.	N-Methylaspartate	74-78	interleukin 1 beta	Homo sapiens	0-8
20348922-5	2010	The proconvulsant effects of HMGB1, like those of interleukin-1beta (IL-1beta), are partly mediated by ifenprodil-sensitive N-methyl-d-aspartate (NMDA) receptors.	ifenprodil	103-113	interleukin 1 beta	Homo sapiens	50-67
20348922-5	2010	The proconvulsant effects of HMGB1, like those of interleukin-1beta (IL-1beta), are partly mediated by ifenprodil-sensitive N-methyl-d-aspartate (NMDA) receptors.	ifenprodil	103-113	interleukin 1 beta	Homo sapiens	69-77
20060906-2	2010	IL-1beta inhibits N-methyl-d-aspartate (NMDA)-induced outward currents (I(NMDA-OUT)) through IL-1 type I receptor (IL-1RI) in hippocampal CA1 neurons (Zhang, R., Yamada, J., Hayashi, Y., Wu, Z, Koyama, S., Nakanishi, H., 2008.	N-Methylaspartate	18-38	interleukin 1 beta	Homo sapiens	0-8
20060906-3	2010	Inhibition of NMDA-induced outward currents by interleukin-1beta in hippocampal neurons, Biochem.	N-Methylaspartate	14-18	interleukin 1 beta	Homo sapiens	47-64
20060906-8	2010	Although IL-1RI is associated with mitogen-activated protein kinases, their involvement in the effect of IL-1beta on I(NMDA-OUT) remains unclear.	N-Methylaspartate	119-123	interleukin 1 beta	Homo sapiens	105-113
20304332-6	2010	Moreover, interleukin-1beta may activate the turnover of hypothalamic neural histamine.	Histamine	77-86	interleukin 1 beta	Homo sapiens	10-27
20060906-9	2010	In the present study, we demonstrate that IL-1beta caused activation of p38 mitogen-activated protein kinase and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I(NMDA-OUT) in hippocampal CA1 neurons.	SB 203580	136-144	interleukin 1 beta	Homo sapiens	181-189
20060906-9	2010	In the present study, we demonstrate that IL-1beta caused activation of p38 mitogen-activated protein kinase and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I(NMDA-OUT) in hippocampal CA1 neurons.	N-Methylaspartate	195-199	interleukin 1 beta	Homo sapiens	181-189
20060906-13	2010	These results suggest that IL-1beta increases the excitability of hippocampal CA1 neurons in the p38-dependent inhibition of I(NMDA-OUT).	N-Methylaspartate	127-131	interleukin 1 beta	Homo sapiens	27-35
20105457-8	2010	Cd(2+) induced an increased release of IL-6 and MIP-2/CXCL2 from the epithelial cells and MIP-2, IL-1beta and TNF-alpha from alveolar macrophages.	Cadmium ion	0-6	interleukin 1 beta	Homo sapiens	97-105
19945523-0	2010	Methamphetamine cytotoxicity and effect on LPS-stimulated IL-1beta production by human monocytes.	Methamphetamine	0-15	interleukin 1 beta	Homo sapiens	58-66
19945523-9	2010	However, METH generally increased LPS-stimulated IL-1beta levels, reaching statistical significance at 5x10(-5)M METH ( approximately 50% to &gt;100% increase).	Methamphetamine	9-13	interleukin 1 beta	Homo sapiens	49-57
19945523-10	2010	The study suggests that METH potentiation of periodontopathogen LPS stimulation of IL-1beta in monocytes could contribute to periodontitis in METH abusers, consistent with other studies suggesting a role for increased IL-1beta in deleterious effects of METH.	Methamphetamine	24-28	interleukin 1 beta	Homo sapiens	83-91
19945523-10	2010	The study suggests that METH potentiation of periodontopathogen LPS stimulation of IL-1beta in monocytes could contribute to periodontitis in METH abusers, consistent with other studies suggesting a role for increased IL-1beta in deleterious effects of METH.	Methamphetamine	24-28	interleukin 1 beta	Homo sapiens	218-226
19945523-10	2010	The study suggests that METH potentiation of periodontopathogen LPS stimulation of IL-1beta in monocytes could contribute to periodontitis in METH abusers, consistent with other studies suggesting a role for increased IL-1beta in deleterious effects of METH.	Methamphetamine	142-146	interleukin 1 beta	Homo sapiens	83-91
19945523-10	2010	The study suggests that METH potentiation of periodontopathogen LPS stimulation of IL-1beta in monocytes could contribute to periodontitis in METH abusers, consistent with other studies suggesting a role for increased IL-1beta in deleterious effects of METH.	Methamphetamine	142-146	interleukin 1 beta	Homo sapiens	83-91
20067446-9	2010	Data provided prove that, in FLSs, constitutive as well as IL-1beta-induced expression of IL-6 is transiently and partially down-regulated by the short treatment of cells with low concentrations of NaHS.	sodium bisulfide	198-202	interleukin 1 beta	Homo sapiens	59-67
20416175-10	2010	Interestingly, LY294002, not SB203580 and U0126, inhibited the up-regulation of fMLP-R and IL-1beta by IL-27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 1 beta	Homo sapiens	91-99
20368105-0	2010	[Effect of Nivalenol and selenium on IL-1beta and TNF-alpha secretion in cultured chondrocytes].	Selenium	25-33	interleukin 1 beta	Homo sapiens	37-45
20368105-1	2010	AIM: To investigate the effect of Nivalenol(NIV) and Selenium(Se) on the levels of IL-1beta and TNF-alpha in the cultured chondrocytes.	nivalenol	34-43	interleukin 1 beta	Homo sapiens	83-91
20368105-1	2010	AIM: To investigate the effect of Nivalenol(NIV) and Selenium(Se) on the levels of IL-1beta and TNF-alpha in the cultured chondrocytes.	Selenium	53-61	interleukin 1 beta	Homo sapiens	83-91
20368105-1	2010	AIM: To investigate the effect of Nivalenol(NIV) and Selenium(Se) on the levels of IL-1beta and TNF-alpha in the cultured chondrocytes.	Selenium	53-55	interleukin 1 beta	Homo sapiens	83-91
20302643-7	2010	Increased secretion of IL-1beta was dependent upon p38 MAP kinase activity while Abeta1-40 secretion required Src family kinase activity since the specific p38 inhibitor, SB202190, and the Src family kinase inhibitor, PP2, attenuated IL-1beta and Abeta1-40 secretion, respectively.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	171-179	interleukin 1 beta	Homo sapiens	23-31
20206126-4	2010	We show here that endogenous and plant-derived inhibitors of the Na(+)/K(+)-ATPase, i.e. the cardiac glycosides ouabain and digitoxin, inhibit IL-1beta- and IL-6-induced APP expression in human hepatoma cells and primary human hepatocytes (PHH) at nanomolar concentrations.	Digitoxin	124-133	interleukin 1 beta	Homo sapiens	143-151
20302643-7	2010	Increased secretion of IL-1beta was dependent upon p38 MAP kinase activity while Abeta1-40 secretion required Src family kinase activity since the specific p38 inhibitor, SB202190, and the Src family kinase inhibitor, PP2, attenuated IL-1beta and Abeta1-40 secretion, respectively.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	171-179	interleukin 1 beta	Homo sapiens	234-242
20100175-3	2010	IL-1beta induced GM-CSF release into the culture medium by 6 h and in cell lysates (cytosolic) at 2 h. These effects were profoundly inhibited by dexamethasone, yet IL-1beta-induced GM-CSF mRNA and unspliced nRNA (nuclear RNA; a surrogate of transcription rate) were modestly inhibited by dexamethasone at times up to 2 h. Although this indicates an effect on protein synthesis, actinomycin D chase experiments also indicated post-transcriptional repression by dexamethasone.	Dexamethasone	146-159	interleukin 1 beta	Homo sapiens	0-8
20138213-5	2010	There was a significant decrease in IL-1beta (p&lt;0.01), TNF-alpha (p&lt;0.001) and IL-10 (p&lt;0.001) secretion after dexamethasone loaded SLN administration, compared to dexamethasone alone at the highest concentration tested (250 nM) at 24h exposure.	Dexamethasone	120-133	interleukin 1 beta	Homo sapiens	36-44
20100175-3	2010	IL-1beta induced GM-CSF release into the culture medium by 6 h and in cell lysates (cytosolic) at 2 h. These effects were profoundly inhibited by dexamethasone, yet IL-1beta-induced GM-CSF mRNA and unspliced nRNA (nuclear RNA; a surrogate of transcription rate) were modestly inhibited by dexamethasone at times up to 2 h. Although this indicates an effect on protein synthesis, actinomycin D chase experiments also indicated post-transcriptional repression by dexamethasone.	Dactinomycin	379-392	interleukin 1 beta	Homo sapiens	0-8
20100175-3	2010	IL-1beta induced GM-CSF release into the culture medium by 6 h and in cell lysates (cytosolic) at 2 h. These effects were profoundly inhibited by dexamethasone, yet IL-1beta-induced GM-CSF mRNA and unspliced nRNA (nuclear RNA; a surrogate of transcription rate) were modestly inhibited by dexamethasone at times up to 2 h. Although this indicates an effect on protein synthesis, actinomycin D chase experiments also indicated post-transcriptional repression by dexamethasone.	Dexamethasone	289-302	interleukin 1 beta	Homo sapiens	0-8
20100175-3	2010	IL-1beta induced GM-CSF release into the culture medium by 6 h and in cell lysates (cytosolic) at 2 h. These effects were profoundly inhibited by dexamethasone, yet IL-1beta-induced GM-CSF mRNA and unspliced nRNA (nuclear RNA; a surrogate of transcription rate) were modestly inhibited by dexamethasone at times up to 2 h. Although this indicates an effect on protein synthesis, actinomycin D chase experiments also indicated post-transcriptional repression by dexamethasone.	Dactinomycin	379-392	interleukin 1 beta	Homo sapiens	165-173
20100175-3	2010	IL-1beta induced GM-CSF release into the culture medium by 6 h and in cell lysates (cytosolic) at 2 h. These effects were profoundly inhibited by dexamethasone, yet IL-1beta-induced GM-CSF mRNA and unspliced nRNA (nuclear RNA; a surrogate of transcription rate) were modestly inhibited by dexamethasone at times up to 2 h. Although this indicates an effect on protein synthesis, actinomycin D chase experiments also indicated post-transcriptional repression by dexamethasone.	Dexamethasone	289-302	interleukin 1 beta	Homo sapiens	0-8
20100175-3	2010	IL-1beta induced GM-CSF release into the culture medium by 6 h and in cell lysates (cytosolic) at 2 h. These effects were profoundly inhibited by dexamethasone, yet IL-1beta-induced GM-CSF mRNA and unspliced nRNA (nuclear RNA; a surrogate of transcription rate) were modestly inhibited by dexamethasone at times up to 2 h. Although this indicates an effect on protein synthesis, actinomycin D chase experiments also indicated post-transcriptional repression by dexamethasone.	Dexamethasone	289-302	interleukin 1 beta	Homo sapiens	165-173
20100175-3	2010	IL-1beta induced GM-CSF release into the culture medium by 6 h and in cell lysates (cytosolic) at 2 h. These effects were profoundly inhibited by dexamethasone, yet IL-1beta-induced GM-CSF mRNA and unspliced nRNA (nuclear RNA; a surrogate of transcription rate) were modestly inhibited by dexamethasone at times up to 2 h. Although this indicates an effect on protein synthesis, actinomycin D chase experiments also indicated post-transcriptional repression by dexamethasone.	Dexamethasone	289-302	interleukin 1 beta	Homo sapiens	165-173
20065062-3	2010	Daptomycin led to lower CSF concentrations of interleukin 1beta (IL-1beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1alpha) (P &lt; 0.05).	Daptomycin	0-10	interleukin 1 beta	Homo sapiens	46-63
20100175-6	2010	At 2 h, IL-1beta-induced expression of GM-CSF protein, but not mRNA, was sensitive to the MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase] inhibitors PD098059 and U0126.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	198-206	interleukin 1 beta	Homo sapiens	8-16
20100175-6	2010	At 2 h, IL-1beta-induced expression of GM-CSF protein, but not mRNA, was sensitive to the MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase] inhibitors PD098059 and U0126.	U 0126	211-216	interleukin 1 beta	Homo sapiens	8-16
20100175-8	2010	Dexamethasone and RU24858 both reduced IL-1beta-induced ERK phosphorylation and increased MKP-1 (MAPK phosphatase-1) expression.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	39-47
20100175-8	2010	Dexamethasone and RU24858 both reduced IL-1beta-induced ERK phosphorylation and increased MKP-1 (MAPK phosphatase-1) expression.	RU24858	18-25	interleukin 1 beta	Homo sapiens	39-47
20065062-3	2010	Daptomycin led to lower CSF concentrations of interleukin 1beta (IL-1beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1alpha) (P &lt; 0.05).	Daptomycin	0-10	interleukin 1 beta	Homo sapiens	65-73
20118567-6	2010	In contrast, nifedipine and verapamil suppressed the production of IL-1beta, TNF-alpha, and IFN-gamma.	Nifedipine	13-23	interleukin 1 beta	Homo sapiens	67-75
20131233-9	2010	Increased expression of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 induced by lipopolysaccharide was attenuated by cilostazol and CoPP, and this was reversed by ZnPP.	Cilostazol	151-161	interleukin 1 beta	Homo sapiens	64-81
20131233-9	2010	Increased expression of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 induced by lipopolysaccharide was attenuated by cilostazol and CoPP, and this was reversed by ZnPP.	Cilostazol	151-161	interleukin 1 beta	Homo sapiens	83-91
20131233-9	2010	Increased expression of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 induced by lipopolysaccharide was attenuated by cilostazol and CoPP, and this was reversed by ZnPP.	cobaltiprotoporphyrin	166-170	interleukin 1 beta	Homo sapiens	64-81
20131233-9	2010	Increased expression of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 induced by lipopolysaccharide was attenuated by cilostazol and CoPP, and this was reversed by ZnPP.	cobaltiprotoporphyrin	166-170	interleukin 1 beta	Homo sapiens	83-91
20131233-9	2010	Increased expression of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 induced by lipopolysaccharide was attenuated by cilostazol and CoPP, and this was reversed by ZnPP.	zinc protoporphyrin	197-201	interleukin 1 beta	Homo sapiens	83-91
19878610-0	2010	Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	77-85
20118567-6	2010	In contrast, nifedipine and verapamil suppressed the production of IL-1beta, TNF-alpha, and IFN-gamma.	Verapamil	28-37	interleukin 1 beta	Homo sapiens	67-75
20397120-8	2010	RESULTS: CO (2), but not hypoxia, induced a significant reduction in the release of TNF-alpha and IL-8 as well as a significant increase in the release of IL-10 and IL-1 beta within the first 4 h after incubation.	co (2)	9-15	interleukin 1 beta	Homo sapiens	165-174
20026325-0	2010	Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	50-58
20026325-4	2010	It has been reported that elevated osmolarity achieved by adding sodium chloride to the culture medium of corneal epithelial cells increased the production of IL-1beta, a proinflammation cytokine.	Sodium Chloride	65-80	interleukin 1 beta	Homo sapiens	159-167
20026325-11	2010	Pretreatment of curcumin (5muM) completely abolished the increased production of IL-1beta induced by the hyperosmotic medium.	Curcumin	16-24	interleukin 1 beta	Homo sapiens	81-89
20026325-11	2010	Pretreatment of curcumin (5muM) completely abolished the increased production of IL-1beta induced by the hyperosmotic medium.	5mum	26-30	interleukin 1 beta	Homo sapiens	81-89
20026325-13	2010	SB 203580 (p38 inhibitor), but not SP 600125 (JNK inhibitor), completely suppressed hyperosmoticity-induced IL-1beta production, indicating that the inhibition of production of IL-1beta by curcumin may be achieved through the p38 signal pathway.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	108-116
20026325-13	2010	SB 203580 (p38 inhibitor), but not SP 600125 (JNK inhibitor), completely suppressed hyperosmoticity-induced IL-1beta production, indicating that the inhibition of production of IL-1beta by curcumin may be achieved through the p38 signal pathway.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	177-185
20026325-13	2010	SB 203580 (p38 inhibitor), but not SP 600125 (JNK inhibitor), completely suppressed hyperosmoticity-induced IL-1beta production, indicating that the inhibition of production of IL-1beta by curcumin may be achieved through the p38 signal pathway.	Curcumin	189-197	interleukin 1 beta	Homo sapiens	177-185
19702435-0	2010	Interleukin-1beta and surface marker expression changes induced by tetrachloroplatinate in human monocyte-derived dendritic cells.	tetrachloroplatinate	67-87	interleukin 1 beta	Homo sapiens	0-17
19702435-5	2010	Clear up-regulation of IL-1beta mRNA as well as CD54, CD86 and HLA-DR expression in response to NiSO4 (250 microM) was detected after 48 hrs of exposure.	nickel sulfate	96-101	interleukin 1 beta	Homo sapiens	23-31
19702435-7	2010	TCPP (150 microM) similarly to NiSO4 induced up-regulation of IL-1beta mRNA, CD54, CD86, but not HLA-DR expression.	tetracarboxyphenylporphine	0-4	interleukin 1 beta	Homo sapiens	62-70
19702435-7	2010	TCPP (150 microM) similarly to NiSO4 induced up-regulation of IL-1beta mRNA, CD54, CD86, but not HLA-DR expression.	nickel sulfate	31-36	interleukin 1 beta	Homo sapiens	62-70
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	Dexamethasone	47-60	interleukin 1 beta	Homo sapiens	117-125
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	pyrrolidine dithiocarbamic acid	62-89	interleukin 1 beta	Homo sapiens	117-125
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	pyrrolidine dithiocarbamic acid	91-95	interleukin 1 beta	Homo sapiens	117-125
19959635-14	2010	In the presence of IL-1beta, MMC-treated corneal fibroblasts modified HCE cell migration through IL-1beta-induced HGF secretion.	Mitomycin	29-32	interleukin 1 beta	Homo sapiens	19-27
19959635-14	2010	In the presence of IL-1beta, MMC-treated corneal fibroblasts modified HCE cell migration through IL-1beta-induced HGF secretion.	Mitomycin	29-32	interleukin 1 beta	Homo sapiens	97-105
19481766-9	2010	We demonstrated that cAMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB binding due to its blockade of the upstream signal(s) leading to IkappaB phosphorylation and degradation, and is mediated by PKA-independent signaling pathways.	Cyclic AMP	21-25	interleukin 1 beta	Homo sapiens	35-43
19918789-8	2010	Our results showed that PA (1) inhibited anchorage-dependent and -independent A549 growth in a concentration-dependent manner, (2) induced apoptosis and disrupted mitochondrial membrane potential in A549 cells, and at nonlethal levels, (3) decreased IL-1 beta-induced activation of cPLA(2) and COX-2, (4) suppressed IL-1 beta-induced activation of mitogen-activated protein kinases (MAPKs), and (5) inhibited IL-1 beta-stimulated nuclear factor kappa B (NF-kappaB) signaling pathways.	pachymic acid	24-26	interleukin 1 beta	Homo sapiens	250-259
19918789-8	2010	Our results showed that PA (1) inhibited anchorage-dependent and -independent A549 growth in a concentration-dependent manner, (2) induced apoptosis and disrupted mitochondrial membrane potential in A549 cells, and at nonlethal levels, (3) decreased IL-1 beta-induced activation of cPLA(2) and COX-2, (4) suppressed IL-1 beta-induced activation of mitogen-activated protein kinases (MAPKs), and (5) inhibited IL-1 beta-stimulated nuclear factor kappa B (NF-kappaB) signaling pathways.	pachymic acid	24-26	interleukin 1 beta	Homo sapiens	316-325
19918789-8	2010	Our results showed that PA (1) inhibited anchorage-dependent and -independent A549 growth in a concentration-dependent manner, (2) induced apoptosis and disrupted mitochondrial membrane potential in A549 cells, and at nonlethal levels, (3) decreased IL-1 beta-induced activation of cPLA(2) and COX-2, (4) suppressed IL-1 beta-induced activation of mitogen-activated protein kinases (MAPKs), and (5) inhibited IL-1 beta-stimulated nuclear factor kappa B (NF-kappaB) signaling pathways.	pachymic acid	24-26	interleukin 1 beta	Homo sapiens	316-325
22966296-0	2010	Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells.	Glucosamine	57-68	interleukin 1 beta	Homo sapiens	45-53
22966296-0	2010	Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells.	Glucosamine	158-169	interleukin 1 beta	Homo sapiens	45-53
22966296-5	2010	Our data showed that the expression of IL-6, IL-8, TNF-alpha and IL-1beta was decreased by glucosamine treatment in the HaCaT cells.	Glucosamine	91-102	interleukin 1 beta	Homo sapiens	65-73
22966296-7	2010	Notably, curcumin induced an increased expression of IL-8 and IL-1beta in the HaCaT cells, but not that of IL-6 and TNF-alpha.	Curcumin	9-17	interleukin 1 beta	Homo sapiens	62-70
22966296-9	2010	Our data indicated that glucosamine induced the down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta expression in the HaCaT cells.	Glucosamine	24-35	interleukin 1 beta	Homo sapiens	93-101
19895882-11	2010	In comparison with the results for the negative control, both PU and PTFE significantly induced ROS release after 0.5h, while the expressions of TNF-alpha, IL-1beta, and IL-6 were variably increased after 24h.	Polyurethanes	62-64	interleukin 1 beta	Homo sapiens	156-164
20026360-9	2010	In addition, the augmentation of meprin-alpha of the LPS-induced expression of TNF-alpha and IL-1beta was significantly decreased by Bay-117082, an inhibitor of NF-kappaB.	3-(4-methylphenylsulfonyl)-2-propenenitrile	133-143	interleukin 1 beta	Homo sapiens	93-101
20133696-0	2010	Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease.	Reactive Oxygen Species	0-23	interleukin 1 beta	Homo sapiens	54-62
20133696-5	2010	Moreover, activation of CGD monocytes by uric acid crystals induced a 4-fold higher level of IL-1beta secretion compared with that seen in monocytes from unaffected subjects, and this increase was not due to increased synthesis of the IL-1beta precursor.	Uric Acid	41-50	interleukin 1 beta	Homo sapiens	93-101
20133696-7	2010	Examination of the effects exerted by the inhibition of ROS activity by DPI revealed that the decrease in IL-1beta secretion by DPI was actually due to inhibition of IL-1beta gene expression.	Reactive Oxygen Species	56-59	interleukin 1 beta	Homo sapiens	106-114
20133696-7	2010	Examination of the effects exerted by the inhibition of ROS activity by DPI revealed that the decrease in IL-1beta secretion by DPI was actually due to inhibition of IL-1beta gene expression.	diphenyleneiodonium	72-75	interleukin 1 beta	Homo sapiens	106-114
20133696-7	2010	Examination of the effects exerted by the inhibition of ROS activity by DPI revealed that the decrease in IL-1beta secretion by DPI was actually due to inhibition of IL-1beta gene expression.	diphenyleneiodonium	128-131	interleukin 1 beta	Homo sapiens	106-114
20133696-7	2010	Examination of the effects exerted by the inhibition of ROS activity by DPI revealed that the decrease in IL-1beta secretion by DPI was actually due to inhibition of IL-1beta gene expression.	diphenyleneiodonium	128-131	interleukin 1 beta	Homo sapiens	166-174
20018936-5	2010	PD98059, which inhibits mitogen-activated protein kinase kinase/extracellular regulated kinase (MEK/ERK) attenuates IL-1beta-inducible phosphorylation of extracellular signal-regulated kinase 1/2 and mitogen and stress-activated protein kinases 1/2; and reduces levels of phosphorylated and acetylated histone H3.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Homo sapiens	116-124
20018936-7	2010	Conversely, suppression of histone modification with mitogen and stress-activated protein kinase 1/2 short interfering RNA, or the histone H3 acetyltransferase inhibitor Garcinol, inhibits IL-1beta-inducible EGR-1 transcription.	garcinol	170-178	interleukin 1 beta	Homo sapiens	189-197
20018936-9	2010	Acetylated H3 and phosphorylated H3 are enriched at the promoter of EGR-1; and EGR-1 is enriched at the promoters of tissue factor and plasminogen activator inhibitor 1 in response to IL-1beta, and attenuated by PD98059, Garcinol, and mitogen and stress-activated protein kinase 1/2 short interfering RNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	212-219	interleukin 1 beta	Homo sapiens	184-192
20018936-9	2010	Acetylated H3 and phosphorylated H3 are enriched at the promoter of EGR-1; and EGR-1 is enriched at the promoters of tissue factor and plasminogen activator inhibitor 1 in response to IL-1beta, and attenuated by PD98059, Garcinol, and mitogen and stress-activated protein kinase 1/2 short interfering RNA.	garcinol	221-229	interleukin 1 beta	Homo sapiens	184-192
19959635-10	2010	Conditioned medium from MMC-treated fibroblasts exerted a similar concentration-dependent effect on HCE cell migration, enhancing migration most significantly at 0.05 mg/mL MMC in the presence of IL-1beta.	Mitomycin	24-27	interleukin 1 beta	Homo sapiens	196-204
19481766-0	2010	Cyclic AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism.	Cyclic AMP	0-10	interleukin 1 beta	Homo sapiens	20-28
19481766-1	2010	We previously showed that cAMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB binding in primary hepatocytes but the signaling mechanisms responsible for this effect are not understood.	Cyclic AMP	26-30	interleukin 1 beta	Homo sapiens	40-48
19481766-3	2010	Immunofluorescent staining showed that cAMP inhibited IL-1beta plus IFNgamma-induced translocation of NF-kappaB into the nucleus.	Cyclic AMP	39-43	interleukin 1 beta	Homo sapiens	54-62
19481766-4	2010	Western blot analysis showed that the IL-1beta plus IFNgamma- induced phosphorylation and degradation of IkappaBa were markedly inhibited by cAMP.	Cyclic AMP	141-145	interleukin 1 beta	Homo sapiens	38-46
19481766-5	2010	Immunocomplex assay involving GST-IKK revealed that cAMP inhibited IL-1beta plus IFNgamma-induced IKK activity.	Cyclic AMP	52-56	interleukin 1 beta	Homo sapiens	67-75
20116105-3	2010	Results from cytokine antibody arrays demonstrated that half-maximal effective concentrations of the selective beta-AR agonist isoproterenol (Iso) qualitatively increased LPS-mediated expression of the soluble cytokine, interleukin-1beta (IL-1beta).	Isoproterenol	127-140	interleukin 1 beta	Homo sapiens	220-237
20116105-3	2010	Results from cytokine antibody arrays demonstrated that half-maximal effective concentrations of the selective beta-AR agonist isoproterenol (Iso) qualitatively increased LPS-mediated expression of the soluble cytokine, interleukin-1beta (IL-1beta).	Isoproterenol	127-140	interleukin 1 beta	Homo sapiens	239-247
20116105-3	2010	Results from cytokine antibody arrays demonstrated that half-maximal effective concentrations of the selective beta-AR agonist isoproterenol (Iso) qualitatively increased LPS-mediated expression of the soluble cytokine, interleukin-1beta (IL-1beta).	Isoproterenol	142-145	interleukin 1 beta	Homo sapiens	220-237
20116105-3	2010	Results from cytokine antibody arrays demonstrated that half-maximal effective concentrations of the selective beta-AR agonist isoproterenol (Iso) qualitatively increased LPS-mediated expression of the soluble cytokine, interleukin-1beta (IL-1beta).	Isoproterenol	142-145	interleukin 1 beta	Homo sapiens	239-247
20059972-0	2010	Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B.	titanium dioxide	0-16	interleukin 1 beta	Homo sapiens	45-53
19926874-6	2010	In contrast, secondary necrotic VSMCs release both IL-1alpha and caspase-activated IL-1beta, augmenting IL-6 and MCP-1 production.	vsmcs	32-37	interleukin 1 beta	Homo sapiens	83-91
20059972-0	2010	Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B.	Reactive Oxygen Species	148-171	interleukin 1 beta	Homo sapiens	45-53
20059972-1	2010	Although titanium dioxide (TiO2) is widely used, its inhalation can induce inflammatory diseases accompanied by interleukin-1beta (IL-1beta) production.	titanium dioxide	9-25	interleukin 1 beta	Homo sapiens	112-129
20059972-1	2010	Although titanium dioxide (TiO2) is widely used, its inhalation can induce inflammatory diseases accompanied by interleukin-1beta (IL-1beta) production.	titanium dioxide	9-25	interleukin 1 beta	Homo sapiens	131-139
20059972-1	2010	Although titanium dioxide (TiO2) is widely used, its inhalation can induce inflammatory diseases accompanied by interleukin-1beta (IL-1beta) production.	titanium dioxide	27-31	interleukin 1 beta	Homo sapiens	112-129
20059972-1	2010	Although titanium dioxide (TiO2) is widely used, its inhalation can induce inflammatory diseases accompanied by interleukin-1beta (IL-1beta) production.	titanium dioxide	27-31	interleukin 1 beta	Homo sapiens	131-139
20059972-4	2010	Here, we systematically compared the production of IL-1beta in response to various forms of TiO2 by macrophage-like human THP-1 cells using various sizes (nano to micro), crystal structures (anatase or rutile), and shapes (spherical or spicular) of TiO2.	titanium dioxide	92-96	interleukin 1 beta	Homo sapiens	51-59
20059972-4	2010	Here, we systematically compared the production of IL-1beta in response to various forms of TiO2 by macrophage-like human THP-1 cells using various sizes (nano to micro), crystal structures (anatase or rutile), and shapes (spherical or spicular) of TiO2.	titanium dioxide	249-253	interleukin 1 beta	Homo sapiens	51-59
20059972-5	2010	The production of IL-1beta depended dramatically on the characteristics of the TiO2.	titanium dioxide	79-83	interleukin 1 beta	Homo sapiens	18-26
20059972-7	2010	In addition, IL-1beta production depended on active cathepsin B and reactive oxygen species production independent of the characteristics of TiO2.	Reactive Oxygen Species	68-91	interleukin 1 beta	Homo sapiens	13-21
19825412-5	2010	Human IL-1beta overexpression activated glia, elevated murine IL-1beta protein and PGE(2) levels, and increased pro-inflammatory cytokine and chemokine mRNAs specifically within the hippocampus, while having no detectable effect on inflammatory mRNAs in the liver.	Dinoprostone	83-89	interleukin 1 beta	Homo sapiens	6-14
19411613-3	2010	Using bitransgenic (bi-TG) mice in which human (h) IL-1beta is expressed with a doxycycline-inducible system controlled by the Clara cell secretory protein promoter, we have shown that hIL-1beta expression causes a bronchopulmonary dysplasia-like illness in infant mice.	Doxycycline	80-91	interleukin 1 beta	Homo sapiens	185-194
20086177-5	2010	ATP activates purinergic P2RX7 receptors on DC, thus activating the NLRP3/ASC/caspase-1 inflammasome and driving the secretion of interleukin-1beta (IL-1beta).	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	130-147
20219579-0	2010	Mineral trioxide aggregate stimulates macrophages and mast cells to release neutrophil chemotactic factors: role of IL-1beta, MIP-2 and LTB(4).	mineral trioxide	0-16	interleukin 1 beta	Homo sapiens	116-124
20086177-5	2010	ATP activates purinergic P2RX7 receptors on DC, thus activating the NLRP3/ASC/caspase-1 inflammasome and driving the secretion of interleukin-1beta (IL-1beta).	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	149-157
19998410-4	2010	The objective of this study was to investigate direct effects of PGE2 on IL-1beta-induced MMP-1 and MMP-13 expression and the intracellular signaling in articular chondrocytes.	Dinoprostone	65-69	interleukin 1 beta	Homo sapiens	73-81
19926782-7	2010	CONCLUSION: Our findings suggest inflammatory effects on the IL1 system during rosiglitazone therapy in MetSyn.	Rosiglitazone	79-92	interleukin 1 beta	Homo sapiens	61-64
19955102-10	2010	This mechanism may allow IL-1beta, possibly from the developing embryo, to modulate the function of the endometrial epithelium to promote successful implantation, for example by regulating prostaglandin production.	Prostaglandins	189-202	interleukin 1 beta	Homo sapiens	25-33
19998410-5	2010	PGE2 showed inhibitory effects on IL-1beta-induced MMP-1 and MMP-13 expression demonstrated by immunoblotting both in OA and normal chondrocytes, which was further confirmed by enzyme-linked immunosorbent assay and immunohistochemistry of explant cultures of articular cartilages.	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	34-42
19998410-9	2010	These results demonstrate that PGE2 inhibits IL-1beta-induced MMP-1 and MMP-13 productions via EP4 by suppressing MKK4-JNK MAP kinase-c-JUN pathway.	Dinoprostone	31-35	interleukin 1 beta	Homo sapiens	45-53
20005571-7	2010	By contrast, STBM washed from the maternal side of a placental cotyledon and STBM shed by explants cultured in air up-regulated cell surface expression of the adhesion molecule CD54 and induced the production of interleukin (IL)-8, IL-6 and IL-1beta.	stbm	13-17	interleukin 1 beta	Homo sapiens	241-249
19800998-9	2010	Importantly, a considerable shift towards alpha-2,3-linked sialic acids and alpha-2,3-specific SiaT mRNA levels occurred in primary chondrocytes treated with IL-1beta or tumour necrosis factor-alpha (TNF-alpha).	Sialic Acids	59-71	interleukin 1 beta	Homo sapiens	158-166
19836480-6	2010	RESULTS: Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1beta) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of beta1-integrin expression.	Curcumin	36-44	interleukin 1 beta	Homo sapiens	103-121
19836480-6	2010	RESULTS: Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1beta) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of beta1-integrin expression.	Curcumin	36-44	interleukin 1 beta	Homo sapiens	123-131
19836480-7	2010	Curcumin blocks IL-1beta-induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	16-24
20070836-7	2010	SP600125 inhibited the UVA-induced increase in the expression of TNF-alpha mRNA and protein and in the expression of IL-1beta mRNA.	pyrazolanthrone	0-8	interleukin 1 beta	Homo sapiens	117-125
20070836-7	2010	SP600125 inhibited the UVA-induced increase in the expression of TNF-alpha mRNA and protein and in the expression of IL-1beta mRNA.	uva	23-26	interleukin 1 beta	Homo sapiens	117-125
20005571-7	2010	By contrast, STBM washed from the maternal side of a placental cotyledon and STBM shed by explants cultured in air up-regulated cell surface expression of the adhesion molecule CD54 and induced the production of interleukin (IL)-8, IL-6 and IL-1beta.	stbm	77-81	interleukin 1 beta	Homo sapiens	241-249
20919648-1	2010	Evidence has consistently indicated that activation of sphingomyelinases and/or ceramide synthases and the resulting accumulation of ceramide mediate cellular responses to stressors such as lipopolysaccharide, interleukin 1beta, tumor necrosis factor alpha, serum deprivation, irradiation and various antitumor treatments.	Ceramides	80-88	interleukin 1 beta	Homo sapiens	210-256
20026181-8	2010	Application of 10% FBS to serum-free astrocyte cultures quickly evoked a roughly seven-fold increase in NFAT activity that was significantly reduced by co-delivery of neutralizing agents for IL-1 beta, TNFalpha, and/or IFN gamma, suggesting that serum occludes evoked NFAT activation through a cytokine-based mechanism.	occludes	252-260	interleukin 1 beta	Homo sapiens	191-200
19774507-0	2010	Screening of five essential oils for identification of potential inhibitors of IL-1-induced Nf-kappaB activation and NO production in human chondrocytes: characterization of the inhibitory activity of alpha-pinene.	Oils, Volatile	18-32	interleukin 1 beta	Homo sapiens	79-83
19774507-0	2010	Screening of five essential oils for identification of potential inhibitors of IL-1-induced Nf-kappaB activation and NO production in human chondrocytes: characterization of the inhibitory activity of alpha-pinene.	alpha-pinene	201-213	interleukin 1 beta	Homo sapiens	79-83
19774507-1	2010	Nuclear factor-kappaB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1beta (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases.	Nitric Oxide	210-222	interleukin 1 beta	Homo sapiens	115-119
19774507-7	2010	The essential oil from the leaves of J. oxycedrus in a concentration of 0.02 % (v/v) achieved the greatest inhibition (80 +/- 8%) of IL-1-induced NO production.	Oils, Volatile	4-17	interleukin 1 beta	Homo sapiens	133-137
19774507-9	2010	Similarly to the effect of the whole oil, a fraction containing 93% alpha-pinene reduced significantly IL-1-induced I kappaB-alpha degradation.	Oils	37-40	interleukin 1 beta	Homo sapiens	103-107
19774507-9	2010	Similarly to the effect of the whole oil, a fraction containing 93% alpha-pinene reduced significantly IL-1-induced I kappaB-alpha degradation.	alpha-pinene	68-80	interleukin 1 beta	Homo sapiens	103-107
19774507-12	2010	The ability of the alpha-pinene-containing fraction to reduce IL-1-induced NF-kappaB activation and NO production warrants further studies to demonstrate the usefulness of alpha-pinene in the treatment of arthritic diseases and other conditions in which NF-kappaB and NO play pathological roles.	alpha-pinene	19-31	interleukin 1 beta	Homo sapiens	62-66
19774507-12	2010	The ability of the alpha-pinene-containing fraction to reduce IL-1-induced NF-kappaB activation and NO production warrants further studies to demonstrate the usefulness of alpha-pinene in the treatment of arthritic diseases and other conditions in which NF-kappaB and NO play pathological roles.	alpha-pinene	172-184	interleukin 1 beta	Homo sapiens	62-66
19833175-0	2010	Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.	morphine-3-glucuronide	26-48	interleukin 1 beta	Homo sapiens	110-127
21222263-9	2010	KdPT, a derivative of KPV corresponding to IL-1beta(193-195), currently is emerging as another tripeptide with potent anti-inflammatory effects.	tripeptide K-26	95-105	interleukin 1 beta	Homo sapiens	43-51
20955562-13	2010	In addition, we also demonstrate that polyphenol rich PE inhibited the IL-1beta-induced activation of MKK3, p38alpha-MAPK isoform and DNA binding activity of the transcription factor RUNX-2.	Polyphenols	38-48	interleukin 1 beta	Homo sapiens	71-79
19797159-7	2010	Hydrogen peroxide (H(2)O(2)) and SIN1 as well as the cytokine mixture (IFN-gamma, IL-1beta, and tumor necrosis factor-alpha) increased mRNA expression and activity of nNOS in A549 cells in a concentration-dependent manner compared with nontreated cells.	Hydrogen Peroxide	0-17	interleukin 1 beta	Homo sapiens	82-90
20039418-11	2010	Fasudil inhibited IL-1beta-induced activation of NF-kappaB independent of the inhibition of IkappaBalpha degradation and nuclear translocation of NF-kappaB, and inhibited IL-1beta-induced DNA binding of NF-kappaB.	fasudil	0-7	interleukin 1 beta	Homo sapiens	18-26
20039418-11	2010	Fasudil inhibited IL-1beta-induced activation of NF-kappaB independent of the inhibition of IkappaBalpha degradation and nuclear translocation of NF-kappaB, and inhibited IL-1beta-induced DNA binding of NF-kappaB.	fasudil	0-7	interleukin 1 beta	Homo sapiens	171-179
20430256-5	2010	Taurine, a semi-essential amino acid, is an antioxidant, inhibits the production of proinflammatory cytokines such as IL-1 and IL-6 and also inhibits production of TGF-beta, a major fibrogenic cytokine.	Taurine	0-7	interleukin 1 beta	Homo sapiens	118-122
20460758-0	2010	Inhibitory effect of vitamin K(2) on interleukin-1beta-stimulated proliferation of human osteoblasts.	Vitamin K	21-30	interleukin 1 beta	Homo sapiens	37-54
20190401-2	2010	Both CS-SC and CS-PC (from 1 to 100 mug/ml) effectively suppressed the interleukin (IL)-1beta (10 ng/ml)-enhanced gene expression of aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 in articular chondrocytes embedded in alginate beads and synovial fibroblasts.	Chondroitin Sulfates	5-7	interleukin 1 beta	Homo sapiens	71-93
20190401-2	2010	Both CS-SC and CS-PC (from 1 to 100 mug/ml) effectively suppressed the interleukin (IL)-1beta (10 ng/ml)-enhanced gene expression of aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 in articular chondrocytes embedded in alginate beads and synovial fibroblasts.	cs-pc	15-20	interleukin 1 beta	Homo sapiens	71-93
20190401-2	2010	Both CS-SC and CS-PC (from 1 to 100 mug/ml) effectively suppressed the interleukin (IL)-1beta (10 ng/ml)-enhanced gene expression of aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 in articular chondrocytes embedded in alginate beads and synovial fibroblasts.	Alginates	291-299	interleukin 1 beta	Homo sapiens	71-93
20190401-3	2010	In addition, CS-SC and CS-PC overcame the IL-1beta-mediated suppression of the aggrecan core protein mRNA, and suppressed the IL-1beta-enhanced collagenase-3/matrix metalloproteinase (MMP)-13 gene expression in chondrocytes.	cs-sc	13-18	interleukin 1 beta	Homo sapiens	42-50
20190401-3	2010	In addition, CS-SC and CS-PC overcame the IL-1beta-mediated suppression of the aggrecan core protein mRNA, and suppressed the IL-1beta-enhanced collagenase-3/matrix metalloproteinase (MMP)-13 gene expression in chondrocytes.	cs-sc	13-18	interleukin 1 beta	Homo sapiens	126-134
20190401-3	2010	In addition, CS-SC and CS-PC overcame the IL-1beta-mediated suppression of the aggrecan core protein mRNA, and suppressed the IL-1beta-enhanced collagenase-3/matrix metalloproteinase (MMP)-13 gene expression in chondrocytes.	cs-pc	23-28	interleukin 1 beta	Homo sapiens	42-50
20190401-3	2010	In addition, CS-SC and CS-PC overcame the IL-1beta-mediated suppression of the aggrecan core protein mRNA, and suppressed the IL-1beta-enhanced collagenase-3/matrix metalloproteinase (MMP)-13 gene expression in chondrocytes.	cs-pc	23-28	interleukin 1 beta	Homo sapiens	126-134
20190401-4	2010	CS-PC, but not CS-SC effectively recovered the IL-1beta-reduced gene expression of tissue inhibitor of metalloproteinases (TIMP)-3 in chondrocytes, and enhanced the production of TIMP-1 in synovial fibroblasts.	Chondroitin Sulfates	0-2	interleukin 1 beta	Homo sapiens	47-55
20460758-5	2010	The IL-1beta -stimulated proliferation was inhibited by the MAPK kinase (MEK) inhibitor PD98059 but not by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 or the cyclooxygenase-2 specific inhibitor NS-398, suggesting that IL-1beta stimulated proliferation via MEK, without affecting prostaglandin E(2) synthesis.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	88-95	interleukin 1 beta	Homo sapiens	4-12
20460758-5	2010	The IL-1beta -stimulated proliferation was inhibited by the MAPK kinase (MEK) inhibitor PD98059 but not by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 or the cyclooxygenase-2 specific inhibitor NS-398, suggesting that IL-1beta stimulated proliferation via MEK, without affecting prostaglandin E(2) synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	217-223	interleukin 1 beta	Homo sapiens	4-12
20460758-5	2010	The IL-1beta -stimulated proliferation was inhibited by the MAPK kinase (MEK) inhibitor PD98059 but not by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 or the cyclooxygenase-2 specific inhibitor NS-398, suggesting that IL-1beta stimulated proliferation via MEK, without affecting prostaglandin E(2) synthesis.	Dinoprostone	302-320	interleukin 1 beta	Homo sapiens	4-12
20460758-6	2010	IL-1beta stimulated cellular proliferation but inhibited the synthesis of osteocalcin containing gamma-carboxylated glutamic acid (Gla-OSCAL).	gamma-carboxylated glutamic acid	97-129	interleukin 1 beta	Homo sapiens	0-8
20460758-8	2010	Furthermore, the inhibitory effect of VK(2) on IL-1beta -stimulated proliferation was suppressed by warfarin.	Warfarin	100-108	interleukin 1 beta	Homo sapiens	47-55
19914076-1	2010	Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1beta stimulated synovial fibroblasts.	aminopyridinecarboxamide	10-34	interleukin 1 beta	Homo sapiens	119-127
19782393-6	2010	We demonstrated that a poly(ethylene glycol)-containing hydrogel network, formed by native chemical ligation and presenting an inhibitory peptide for islet cell surface IL-1 receptor, was able to maintain the viability of encapsulated islet cells in the presence of a combination of cytokines including IL-1 beta, TNF-alpha, and INF-gamma.	Polyethylene Glycols	23-44	interleukin 1 beta	Homo sapiens	303-312
20930332-5	2010	Moreover, we found recently that FoxO transcription factors could be involved on Diacerhein mode of action, a drug that reduces the IL-1beta deleterious effects on osteoarthritis cartilage through inhibition of the expression of degrading enzymes.	diacerein	81-91	interleukin 1 beta	Homo sapiens	132-140
20378994-2	2010	We demonstrate that agaro-oligosaccharides suppressed the elevated levels of nitric oxide, prostaglandin E(2), and such pro-inflammatory cytokines as tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 in lipopolysaccharide-stimulated monocytes and macrophages.	agaro-oligosaccharides	20-42	interleukin 1 beta	Homo sapiens	179-196
19737897-6	2010	PGA treatment of differentiated THP-1 cells and hMoDCs led to the specific extracellular release of interleukin-1beta (IL-1beta) in a dose-dependent manner.	Folic Acid	0-3	interleukin 1 beta	Homo sapiens	100-117
20622461-5	2010	In addition, treating with the sulfated polysaccharides increased the nitric oxide (NO) and cytokine (IL-1beta and TNF-alpha) release to levels comparable to those detected in the positive control, lipopolysaccharide (LPS), suggesting that the sulfated polysaccharides might have strong immunomodulatory activity.	Polysaccharides	40-55	interleukin 1 beta	Homo sapiens	102-110
19629677-8	2010	IL-1beta, IL-6 and TNF-alpha also significantly reduced the BCRP activity as assessed by mitoxantrone uptake experiments.	Mitoxantrone	89-101	interleukin 1 beta	Homo sapiens	0-8
20538267-0	2010	Effects of hesperetin on the production of inflammatory mediators in IL-1beta treated human synovial cells.	hesperetin	11-21	interleukin 1 beta	Homo sapiens	69-77
20538267-1	2010	This study was conducted to evaluate the efficacy of hesperetin in regulating interleukin-1beta (IL-1beta)-induced production of the matrix metalloproteinase (MMP)-3 and IL-6 in human synovial cell line, SW982.	hesperetin	53-63	interleukin 1 beta	Homo sapiens	78-95
20538267-1	2010	This study was conducted to evaluate the efficacy of hesperetin in regulating interleukin-1beta (IL-1beta)-induced production of the matrix metalloproteinase (MMP)-3 and IL-6 in human synovial cell line, SW982.	hesperetin	53-63	interleukin 1 beta	Homo sapiens	97-105
20538267-2	2010	Treatment with hesperetin at 1 or 10 microM significantly (P&lt;0.05) inhibited IL-1beta-induced MMP-3 and IL-6 production when measured by enzyme-linked immunosorbent assay (ELISA).	hesperetin	15-25	interleukin 1 beta	Homo sapiens	80-88
20538267-4	2010	IL-1beta-induced JNK activation was inhibited by hesperetin.	hesperetin	49-59	interleukin 1 beta	Homo sapiens	0-8
20840057-7	2010	Results demonstrate that the isolated Cyclo-pentano phenanthrenol inhibits TNF-alpha, IL-1beta and IL-6 expression, NO release via iNOS suppression, prostaglandin biosynthesis via PLA2 and COX-2 inhibition and the activation of intracellular targets, MAPK and NF-kappaB.	cyclo-pentano phenanthrenol	38-65	interleukin 1 beta	Homo sapiens	86-94
20594343-5	2010	Curcumin is a phytochemical capable of inhibiting IL-1beta-induced activation of NF-kappaB and expression of apoptotic and pro-inflammatory genes in chondrocytes.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	50-58
20594343-6	2010	Therefore, the aim of the present study was to evaluate the influence of curcumin on IL-1beta-induced NF-kappaB signalling pathway in MSCs during chondrogenic differentiation.	Curcumin	73-81	interleukin 1 beta	Homo sapiens	85-93
20594343-8	2010	RESULTS: We demonstrate that although curcumin alone does not have chondrogenic effects on MSCs, it inhibits IL-1beta-induced activation of NF-kappaB, activation of caspase-3 and cyclooxygenase-2 in MSCs time and concentration dependently, as it does in chondrocytes.	Curcumin	38-46	interleukin 1 beta	Homo sapiens	109-117
20594343-9	2010	In IL-1beta stimulated co-cultures, four-hour pre-treatment with curcumin significantly enhanced the production of collagen type II, cartilage specific proteoglycans (CSPGs), beta1-integrin, as well as activating MAPKinase signaling and suppressing caspase-3 and cyclooxygenase-2.	Curcumin	65-73	interleukin 1 beta	Homo sapiens	3-11
20332635-0	2010	Dehydroxymethylepoxyquinomicin inhibits expression and production of inflammatory mediators in interleukin-1beta-induced human chondrocytes.	dehydroxymethylepoxyquinomicin	0-30	interleukin 1 beta	Homo sapiens	95-112
20332635-1	2010	The present research was carried out to determine the effects of a nuclear factor-kappaB (NF-kappaB) inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), derivative of the antibiotic epoxyquinomicin C, on normal human chondrocytes treated with interleukin-1beta (IL-1beta).	dehydroxymethylepoxyquinomicin	112-142	interleukin 1 beta	Homo sapiens	242-259
20332635-1	2010	The present research was carried out to determine the effects of a nuclear factor-kappaB (NF-kappaB) inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), derivative of the antibiotic epoxyquinomicin C, on normal human chondrocytes treated with interleukin-1beta (IL-1beta).	dehydroxymethylepoxyquinomicin	112-142	interleukin 1 beta	Homo sapiens	261-269
20332635-1	2010	The present research was carried out to determine the effects of a nuclear factor-kappaB (NF-kappaB) inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), derivative of the antibiotic epoxyquinomicin C, on normal human chondrocytes treated with interleukin-1beta (IL-1beta).	dehydroxymethylepoxyquinomicin	144-149	interleukin 1 beta	Homo sapiens	242-259
20332635-1	2010	The present research was carried out to determine the effects of a nuclear factor-kappaB (NF-kappaB) inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), derivative of the antibiotic epoxyquinomicin C, on normal human chondrocytes treated with interleukin-1beta (IL-1beta).	dehydroxymethylepoxyquinomicin	144-149	interleukin 1 beta	Homo sapiens	261-269
20332635-7	2010	DHMEQ helps to decrease the expression and production of pro-inflammatory mediators in IL-1beta-induced chondrocytes.	dehydroxymethylepoxyquinomicin	0-5	interleukin 1 beta	Homo sapiens	87-95
19669392-0	2010	Dynamic compression alters NFkappaB activation and IkappaB-alpha expression in IL-1beta-stimulated chondrocyte/agarose constructs.	Sepharose	111-118	interleukin 1 beta	Homo sapiens	79-87
19669392-1	2010	OBJECTIVE AND DESIGN: Determine the effect of IL-1beta and dynamic compression on NFkappaB activation and IkappaB-alpha gene expression in chondrocyte/agarose constructs.	Sepharose	151-158	interleukin 1 beta	Homo sapiens	46-54
19737897-6	2010	PGA treatment of differentiated THP-1 cells and hMoDCs led to the specific extracellular release of interleukin-1beta (IL-1beta) in a dose-dependent manner.	Folic Acid	0-3	interleukin 1 beta	Homo sapiens	119-127
19818417-8	2010	Both treatments combined caused the greatest suppression of gene expression; -4.47. qPCR also showed that IL-1beta, GM-CSF and IL-6 mRNA levels were significantly reduced by CSE and further suppressed by dexamethasone.	Dexamethasone	204-217	interleukin 1 beta	Homo sapiens	106-114
19737897-7	2010	Evaluation of IL-1beta processing by Western blotting revealed that cleaved IL-1beta increased in THP-1 cells and hMoDCs after PGA treatment.	Folic Acid	127-130	interleukin 1 beta	Homo sapiens	14-22
19737897-7	2010	Evaluation of IL-1beta processing by Western blotting revealed that cleaved IL-1beta increased in THP-1 cells and hMoDCs after PGA treatment.	Folic Acid	127-130	interleukin 1 beta	Homo sapiens	76-84
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	53-56	interleukin 1 beta	Homo sapiens	29-37
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	53-56	interleukin 1 beta	Homo sapiens	165-173
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	130-133	interleukin 1 beta	Homo sapiens	29-37
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	130-133	interleukin 1 beta	Homo sapiens	165-173
19737897-11	2010	anthracis PGA elicits IL-1beta production through activation of ICE in PMA-differentiated THP-1 cells and hMoDCs, suggesting the potential for PGA as a therapeutic target for anthrax.	anthracis pga	0-13	interleukin 1 beta	Homo sapiens	22-30
19737897-11	2010	anthracis PGA elicits IL-1beta production through activation of ICE in PMA-differentiated THP-1 cells and hMoDCs, suggesting the potential for PGA as a therapeutic target for anthrax.	Folic Acid	10-13	interleukin 1 beta	Homo sapiens	22-30
19918044-10	2010	Increased CXCL10 and IL-1beta levels were associated with the presence of active vasculitis in MC+HCV patients.	mc+hcv	95-101	interleukin 1 beta	Homo sapiens	21-29
20051757-6	2010	The temporal associations of this attack with the initiation of ART and the observed immunologic reconstitution make IRIS a clinical possibility.Monosodium urate crystals through their interactions with interleukin 1- beta, and neutrophilic synovitis play a critical role in the pathophysiology of gout.	Uric Acid	145-161	interleukin 1 beta	Homo sapiens	203-222
20051757-8	2010	The introduction of ART results in restoration of neutrophil and macrophage function, declines in levels of the anti-inflammatory cytokine IL-10, and increases in levels of proinflammatory cytokines including IL-1 beta, which may provide the necessary milieu for the precipitation of attacks of severe polyarticular gout in the context of ART initiation.	art	20-23	interleukin 1 beta	Homo sapiens	209-218
20051757-8	2010	The introduction of ART results in restoration of neutrophil and macrophage function, declines in levels of the anti-inflammatory cytokine IL-10, and increases in levels of proinflammatory cytokines including IL-1 beta, which may provide the necessary milieu for the precipitation of attacks of severe polyarticular gout in the context of ART initiation.	art	339-342	interleukin 1 beta	Homo sapiens	209-218
19623662-5	2010	Incubation of osteoarthritic chondrocyte cultures with atorvastatin produced a significant dose-dependent reduction in IL-1beta production.	Atorvastatin	55-67	interleukin 1 beta	Homo sapiens	119-127
20360622-6	2010	In all groups of dyslipidemic patients, micronized fenofibrate reduced monocyte release of interleukin-1beta and MCP-1, and this effect was stronger in prediabetic subjects.	Fenofibrate	51-62	interleukin 1 beta	Homo sapiens	91-108
20731121-1	2010	It was established that in a mononuclear fraction polyoxidonium inhibited the TNF-alpha production and stimulated the IL-1 beta and IL-6 production.	azoximer bromide	50-63	interleukin 1 beta	Homo sapiens	118-127
20731121-4	2010	The addition of polyoxidonium with dexamethasone to the cultures only in monocyte fraction enhanced the IL-1 beta production as compared with the effect of dexamethasone alone.	azoximer bromide	16-29	interleukin 1 beta	Homo sapiens	104-113
20731121-4	2010	The addition of polyoxidonium with dexamethasone to the cultures only in monocyte fraction enhanced the IL-1 beta production as compared with the effect of dexamethasone alone.	Dexamethasone	35-48	interleukin 1 beta	Homo sapiens	104-113
21173747-2	2010	DESIGN: The aim of our study was to determine if there is a difference between metal influenced IL-1beta, IL-4, IL-6, TNF-alpha and IFN-gamma cytokines production in patients with successfully healed implants compared to those, whose implant therapy was unsuccessful.	Metals	79-84	interleukin 1 beta	Homo sapiens	96-104
21173747-5	2010	RESULTS: IL-1beta levels were significantly increased in all patients after stimulation with titanium and in patients with accepted implants compared to patients with failed implants after the stimulation with mercury and titanium.	Mercury	210-217	interleukin 1 beta	Homo sapiens	9-17
21173747-9	2010	CONCLUSIONS: Increased production of IL-1beta a IL-6 cytokines in reaction to titanium and increased production of TNF-alpha and IFN-gamma cytokines in reaction to mercury, which is very often present in the form of amalgam in the oral cavity of persons in need of implant therapy, can play an important role in immune reactions during implant healing process.	Titanium	78-86	interleukin 1 beta	Homo sapiens	37-45
19786147-10	2010	Pre-incubation of stigmasterol to IL-1beta-treated cells significantly decreased these effects described above (significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE(2) protein in human and mouse) Finally, stigmasterol was capable of counteracting the IL-1beta-induced NF-kappaB pathway.	Stigmasterol	18-30	interleukin 1 beta	Homo sapiens	34-42
19786147-10	2010	Pre-incubation of stigmasterol to IL-1beta-treated cells significantly decreased these effects described above (significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE(2) protein in human and mouse) Finally, stigmasterol was capable of counteracting the IL-1beta-induced NF-kappaB pathway.	Prostaglandins E	248-251	interleukin 1 beta	Homo sapiens	34-42
19786147-10	2010	Pre-incubation of stigmasterol to IL-1beta-treated cells significantly decreased these effects described above (significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE(2) protein in human and mouse) Finally, stigmasterol was capable of counteracting the IL-1beta-induced NF-kappaB pathway.	Stigmasterol	292-304	interleukin 1 beta	Homo sapiens	34-42
19854233-9	2010	Bradykinin increased the zymosan-induced expression of TNF-alpha, and interleukin 1beta (IL-1beta) but did not affect the expression of interleukin 6 (IL-6) or interleukin 10 (IL-10).	Zymosan	25-32	interleukin 1 beta	Homo sapiens	70-87
19854233-9	2010	Bradykinin increased the zymosan-induced expression of TNF-alpha, and interleukin 1beta (IL-1beta) but did not affect the expression of interleukin 6 (IL-6) or interleukin 10 (IL-10).	Zymosan	25-32	interleukin 1 beta	Homo sapiens	89-97
19854233-11	2010	In contrast to the result in human glioma cells, bradykinin inhibits the zymosan-induced expression of TNF-alpha and IL-1beta in rat astrocytes, which shows a species-dependent manner.	Zymosan	73-80	interleukin 1 beta	Homo sapiens	117-125
20180403-6	2010	In the specimens with chronic prostatitis, the expressions of IL-1beta, TNF-alpha and NGF were significantly higher in the 16S rDNA positive than in the 16S rDNA negative group (P &lt; 0.01).	Sulfur	123-126	interleukin 1 beta	Homo sapiens	62-70
20533854-8	2010	H2O2) and NO directly correlated with IL-6, IL-10, IL-1beta, TNFalpha and glutathione.	Hydrogen Peroxide	0-4	interleukin 1 beta	Homo sapiens	51-59
19895372-0	2009	Increased expression of glutathione by estradiol, tumor necrosis factor-alpha, and interleukin 1-beta in endometrial stromal cells.	Glutathione	24-35	interleukin 1 beta	Homo sapiens	83-101
20042083-6	2009	RESULTS: Our results show that the concentrations of ACA in the feeding solution, corresponding to those routinely used in the literature, are limiting for the growth of S. cerevisiae BY4741 [PIR4-IL1beta] in fed-batch reactor.	4-amylcinnamoylanthranilic acid	53-56	interleukin 1 beta	Homo sapiens	197-204
20110869-6	2009	Furthermore we have determined the effect of GS and CS alone (100-500 micromol/L each) and in combination on MMP3 mRNA levels and MMP3 secretion in IL-1beta stimulated chondrocytes.	Chondroitin Sulfates	52-54	interleukin 1 beta	Homo sapiens	148-156
19631617-4	2009	Here, by using a sensitive mice model in which the expression of luciferase reporter gene is under the control of human IL-1beta gene promoter, we examined IL-1beta gene expression pattern in vivo after subacute MPTP toxication in old male and female mice and found that MPTP elicited greater dopaminergic toxicity in old male than in female mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	212-216	interleukin 1 beta	Homo sapiens	156-164
19265174-0	2009	Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice.	Bleomycin	56-65	interleukin 1 beta	Homo sapiens	44-52
20018749-4	2009	Exposure to IL-1beta in fasting glucose activated multiple protein kinases that associate with the insulin gene promoter and transiently increased insulin gene transcription in beta cells.	Glucose	32-39	interleukin 1 beta	Homo sapiens	12-20
19895372-3	2009	METHOD OF STUDY: Glutathione levels were measured utilizing high-performance liquid chromatography following in vitro culture and treatment of ESCs with estradiol, tumor necrosis factor-alpha (TNF-alpha) and interleukin 1-beta (IL-1beta).	Glutathione	17-28	interleukin 1 beta	Homo sapiens	208-226
19895372-3	2009	METHOD OF STUDY: Glutathione levels were measured utilizing high-performance liquid chromatography following in vitro culture and treatment of ESCs with estradiol, tumor necrosis factor-alpha (TNF-alpha) and interleukin 1-beta (IL-1beta).	Glutathione	17-28	interleukin 1 beta	Homo sapiens	228-236
19895372-6	2009	Both IL-1beta 10 ng/mL and E(2) (10(-8) m) plus IL-1beta 10 ng/mL for 48 hr increased GSH level significantly (P &lt; 0.05; P &lt; 0.05, respectively) as well.	Glutathione	86-89	interleukin 1 beta	Homo sapiens	5-13
19895372-6	2009	Both IL-1beta 10 ng/mL and E(2) (10(-8) m) plus IL-1beta 10 ng/mL for 48 hr increased GSH level significantly (P &lt; 0.05; P &lt; 0.05, respectively) as well.	Glutathione	86-89	interleukin 1 beta	Homo sapiens	48-56
19667121-9	2009	LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3-K) activity, inhibited culture- and IL-1beta-induced LN-332 expression in islets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Homo sapiens	97-105
19819943-0	2009	Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Islets of patients with type 2 diabetes mellitus (T2DM) display features of an inflammatory process including elevated levels of the cytokine IL-1beta, various chemokines, and macrophages.	Fatty Acids, Nonesterified	0-16	interleukin 1 beta	Homo sapiens	258-266
19819943-7	2009	Antibody inhibition of IL-1beta revealed that FFA stimulated IL-1RI activity via the induction of the receptor ligand.	Fatty Acids, Nonesterified	46-49	interleukin 1 beta	Homo sapiens	23-31
20025583-3	2009	SHS-induced inflammatory stress, namely interleukin 1beta (IL-1beta), impairs thyroid hormonogenesis and iodine uptake; initiates interleukin 6 (IL-6) production from thyroid epithelial cells and stimulates the expression of molecules that exacerbate thyroid autoimmunity.	Iodine	105-111	interleukin 1 beta	Homo sapiens	40-57
19909337-7	2009	The results of experiments with actinomycin D indicate that lower levels of IL-1beta mRNA are due to shortening of the IL-1beta transcript half-life, and are not related to the presence of AU-rich elements in the 3" UTR.	Dactinomycin	32-45	interleukin 1 beta	Homo sapiens	76-84
19579007-5	2009	RESULTS: In alginate beads and cartilage explant models, Cur inhibited the basal and the IL-1beta-stimulated NO, PGE(2), IL-6, IL-8, and MMP-3 production by human chondrocytes in a concentration-dependent manner.	Prostaglandins E	113-116	interleukin 1 beta	Homo sapiens	89-97
20025583-3	2009	SHS-induced inflammatory stress, namely interleukin 1beta (IL-1beta), impairs thyroid hormonogenesis and iodine uptake; initiates interleukin 6 (IL-6) production from thyroid epithelial cells and stimulates the expression of molecules that exacerbate thyroid autoimmunity.	Iodine	105-111	interleukin 1 beta	Homo sapiens	59-67
20948987-9	2009	In microglia, cocaine up-regulated the immunoregulatory and pro-apoptotic genes IL-1beta and BAX.	Cocaine	14-21	interleukin 1 beta	Homo sapiens	80-88
19961381-11	2009	RESULTS: BOP and IL-1beta levels in GCF showed significant increases from the MD to PgD under optimal plaque control.	pgd	84-87	interleukin 1 beta	Homo sapiens	17-25
19756971-7	2009	All the PEtU-PDMS (poly(ether)urethane-polydimethylsiloxane) films and vascular grafts induced a narrow inflammatory response, as demonstrated by slight cytokine secretion levels, in particular samples with the highest PDMS contents (30 and 40%) induced the lowest IL-1b secretion.	poly(ether)urethane-polydimethylsiloxane	19-59	interleukin 1 beta	Homo sapiens	265-270
19643964-8	2009	The induced caspase-4 and caspase-3 activities by tunicamycin and the stimulated IL-8 protein expression by IL-1beta were markedly reduced by caspase-4 inhibitor Z-LEVD-fmk.	Z-LEVD-FMK	162-172	interleukin 1 beta	Homo sapiens	108-116
19470495-5	2009	RESULTS: In human myotubes exposed to IL-1beta+IFN-gamma, overexpression of APP was accompanied by upregulation of alphaB-crystallin.	alphab-crystallin	115-132	interleukin 1 beta	Homo sapiens	38-56
19748993-2	2009	In vitro exposure of monocytes to oxidized E(h)Cys increases expression of the proinflammatory cytokine, interleukin-1beta (IL-1beta), suggesting that E(h)Cys could be a mechanistic link between oxidative stress and chronic inflammation.	e(h)cys	43-50	interleukin 1 beta	Homo sapiens	105-122
19850345-3	2009	Thymulin selectively ameliorated, in a dose-dependent manner, the endotoxin (ET/LPS [lipopolysaccharide])-induced release of IL-1beta, but not IL-6 or TNF-alpha.	Thymic Factor, Circulating	0-8	interleukin 1 beta	Homo sapiens	125-133
19850345-4	2009	Furthermore, Zn(2+), an anti-inflammatory antioxidant, which is required for the biological activity of thymulin, independently reduced the secretion of IL-1beta, TNF-alpha and, to a lesser extent, at a supraphysiologic dose (1 mM), IL-6.	Zinc	13-18	interleukin 1 beta	Homo sapiens	153-161
19850345-8	2009	To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP.	Colforsin	95-104	interleukin 1 beta	Homo sapiens	200-208
19850345-8	2009	To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP.	Bucladesine	276-282	interleukin 1 beta	Homo sapiens	200-208
19885579-2	2009	The H2-receptor antagonist cimetidine inhibits the increase in E-selectin expression on vascular endothelial cells that is induced by interleukin-1beta (IL-1beta) and cimetidine.	Cimetidine	27-37	interleukin 1 beta	Homo sapiens	134-151
19885579-2	2009	The H2-receptor antagonist cimetidine inhibits the increase in E-selectin expression on vascular endothelial cells that is induced by interleukin-1beta (IL-1beta) and cimetidine.	Cimetidine	27-37	interleukin 1 beta	Homo sapiens	153-161
19748993-2	2009	In vitro exposure of monocytes to oxidized E(h)Cys increases expression of the proinflammatory cytokine, interleukin-1beta (IL-1beta), suggesting that E(h)Cys could be a mechanistic link between oxidative stress and chronic inflammation.	e(h)cys	43-50	interleukin 1 beta	Homo sapiens	124-132
19748993-2	2009	In vitro exposure of monocytes to oxidized E(h)Cys increases expression of the proinflammatory cytokine, interleukin-1beta (IL-1beta), suggesting that E(h)Cys could be a mechanistic link between oxidative stress and chronic inflammation.	Cysteine	47-50	interleukin 1 beta	Homo sapiens	105-122
19748993-2	2009	In vitro exposure of monocytes to oxidized E(h)Cys increases expression of the proinflammatory cytokine, interleukin-1beta (IL-1beta), suggesting that E(h)Cys could be a mechanistic link between oxidative stress and chronic inflammation.	Cysteine	47-50	interleukin 1 beta	Homo sapiens	124-132
19748993-5	2009	Pathway analysis results revealed that in addition to IL-1beta-related pathways, components of stress/detoxification and cell death pathways were increased by oxidized E(h)Cys, while components of cell growth and proliferation pathways were increased by a reduced potential.	Cysteine	172-175	interleukin 1 beta	Homo sapiens	54-62
19801678-1	2009	Recent evidence suggests that signaling by the proinflammatory cytokine interleukin-1beta (IL-1beta) is dependent on reactive oxygen species derived from NADPH oxidase.	Reactive Oxygen Species	117-140	interleukin 1 beta	Homo sapiens	72-89
19801678-1	2009	Recent evidence suggests that signaling by the proinflammatory cytokine interleukin-1beta (IL-1beta) is dependent on reactive oxygen species derived from NADPH oxidase.	Reactive Oxygen Species	117-140	interleukin 1 beta	Homo sapiens	91-99
19772942-6	2009	In vitro, CoVaccineHT upregulated the expression of co-stimulatory molecules both on mouse and human dendritic cells and induced the secretion of pro-inflammatory cytokines TNF-alpha, IL-6, IL-1beta and IL-12p70 in mouse- and IL-6 in human dendritic cells.	covaccineht	10-21	interleukin 1 beta	Homo sapiens	190-198
19765584-0	2009	Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in IL-1beta-stimulated human osteoarthritic synoviocytes and chondrocytes.	Acetylcysteine	40-56	interleukin 1 beta	Homo sapiens	101-109
19765584-5	2009	While NAC significantly diminished PGE(2) release and the expression of both COX-2 and MMP-13 protein in IL-1beta-stimulated synoviocytes, it failed to modify their production in stimulated chondrocytes.	Acetylcysteine	6-9	interleukin 1 beta	Homo sapiens	105-113
19765584-6	2009	Likewise, NAC only inhibited IL-1beta-stimulated NF-kappaB activation in synoviocytes.	Acetylcysteine	10-13	interleukin 1 beta	Homo sapiens	29-37
19783654-6	2009	The interaction of apoA-I with ABCA1-expressing macrophages suppressed the ability of lysopolysaccaride to induce the inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha, which was reversed by silencing STAT3 or ABCA1.	lysopolysaccaride	86-103	interleukin 1 beta	Homo sapiens	141-158
19877066-4	2009	Bisulfite modification was used to identify which CpG sites in the IL1B promoter showed differential methylation between IL1B-expressing and IL1B-nonexpressing cells.	hydrogen sulfite	0-9	interleukin 1 beta	Homo sapiens	67-71
19701245-0	2009	Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3.	Cholecalciferol	114-124	interleukin 1 beta	Homo sapiens	19-27
19701245-6	2009	Vitamin D3, an effective chemopreventive agent, interrupted this crosstalk by blocking the constitutive activation of STAT1 and the production of IL-1beta in macrophages, and therefore-in a vitamin D receptor-dependent manner-inhibited the ability of macrophages to activate Wnt signaling in colon carcinoma cells.	Cholecalciferol	0-10	interleukin 1 beta	Homo sapiens	146-154
19877030-0	2009	Tumor necrosis factor alpha and interleukin-1beta modulate calcium and nitric oxide signaling in mechanically stimulated osteocytes.	Calcium	59-66	interleukin 1 beta	Homo sapiens	32-49
19877030-0	2009	Tumor necrosis factor alpha and interleukin-1beta modulate calcium and nitric oxide signaling in mechanically stimulated osteocytes.	Nitric Oxide	71-83	interleukin 1 beta	Homo sapiens	32-49
19762486-3	2009	Stimulation of CD56+ cells containing both DCs and abundant gammadelta T cells with zoledronate and interleukin-2 (IL-2) resulted in the rapid expansion of gammadelta T cells as well as in IFN-gamma, TNF-alpha, and IL-1beta but not in IL-4, IL-10, or IL-17 production.	Zoledronic Acid	84-95	interleukin 1 beta	Homo sapiens	215-223
19877066-4	2009	Bisulfite modification was used to identify which CpG sites in the IL1B promoter showed differential methylation between IL1B-expressing and IL1B-nonexpressing cells.	hydrogen sulfite	0-9	interleukin 1 beta	Homo sapiens	121-125
19877066-4	2009	Bisulfite modification was used to identify which CpG sites in the IL1B promoter showed differential methylation between IL1B-expressing and IL1B-nonexpressing cells.	hydrogen sulfite	0-9	interleukin 1 beta	Homo sapiens	121-125
19877072-5	2009	RESULTS: Both DEX and CpdA efficiently inhibited IL-1beta gene expression in a GR-dependent manner.	Dexamethasone	14-17	interleukin 1 beta	Homo sapiens	49-57
19877072-5	2009	RESULTS: Both DEX and CpdA efficiently inhibited IL-1beta gene expression in a GR-dependent manner.	CPDA	22-26	interleukin 1 beta	Homo sapiens	49-57
19616091-6	2009	In addition, the IL-1 beta-induced c-Jun phosphorylation was reduced by pretreatment with U0126 or SP600125.	U 0126	90-95	interleukin 1 beta	Homo sapiens	17-26
19800793-4	2009	Moreover, the effect of these derivatives was assessed by measuring their effect on IL-1beta release induced by BzATP-induced activation of differentiated THP-1 cells.	BzATP	112-117	interleukin 1 beta	Homo sapiens	84-92
19616091-6	2009	In addition, the IL-1 beta-induced c-Jun phosphorylation was reduced by pretreatment with U0126 or SP600125.	pyrazolanthrone	99-107	interleukin 1 beta	Homo sapiens	17-26
19616091-7	2009	IL-1 beta stimulated the transcriptional activity of wild-type MMP-9 promoter in A549 cells, which was inhibited by U0126, SB203580, SP600125, and helenalin.	U 0126	116-121	interleukin 1 beta	Homo sapiens	0-9
19616091-7	2009	IL-1 beta stimulated the transcriptional activity of wild-type MMP-9 promoter in A549 cells, which was inhibited by U0126, SB203580, SP600125, and helenalin.	SB 203580	123-131	interleukin 1 beta	Homo sapiens	0-9
19616091-7	2009	IL-1 beta stimulated the transcriptional activity of wild-type MMP-9 promoter in A549 cells, which was inhibited by U0126, SB203580, SP600125, and helenalin.	pyrazolanthrone	133-141	interleukin 1 beta	Homo sapiens	0-9
19616091-7	2009	IL-1 beta stimulated the transcriptional activity of wild-type MMP-9 promoter in A549 cells, which was inhibited by U0126, SB203580, SP600125, and helenalin.	helenalin	147-156	interleukin 1 beta	Homo sapiens	0-9
19616091-9	2009	Finally, the IL-1 beta-induced MMP-9 expression led to cell migration which was attenuated by pretreatment with U0126, SB203580, SP600125, helenalin, or MMP-2/9 inhibitor.	U 0126	112-117	interleukin 1 beta	Homo sapiens	13-22
19616091-9	2009	Finally, the IL-1 beta-induced MMP-9 expression led to cell migration which was attenuated by pretreatment with U0126, SB203580, SP600125, helenalin, or MMP-2/9 inhibitor.	SB 203580	119-127	interleukin 1 beta	Homo sapiens	13-22
19616091-9	2009	Finally, the IL-1 beta-induced MMP-9 expression led to cell migration which was attenuated by pretreatment with U0126, SB203580, SP600125, helenalin, or MMP-2/9 inhibitor.	pyrazolanthrone	129-137	interleukin 1 beta	Homo sapiens	13-22
19616091-9	2009	Finally, the IL-1 beta-induced MMP-9 expression led to cell migration which was attenuated by pretreatment with U0126, SB203580, SP600125, helenalin, or MMP-2/9 inhibitor.	helenalin	139-148	interleukin 1 beta	Homo sapiens	13-22
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	65-83	interleukin 1 beta	Homo sapiens	209-213
19729077-6	2009	Apigenin significantly inhibited the nicotine- and LPS-induced production of NO, PGE2, IL-1beta, TNF-alpha, IL-6, and IL-12, and the upregulation of iNOS and COX-2 in hPDL cells.	Nicotine	37-45	interleukin 1 beta	Homo sapiens	87-95
19446037-7	2009	The histone deacetylase inhibitor Trihostatin A abolished the inhibitory actions of hypoxia on IL-1 beta-induced MCP-1 gene expression.	trihostatin a	34-47	interleukin 1 beta	Homo sapiens	95-104
19446037-9	2009	Although stimulation with IL-1 beta and/or hypoxia increased the acetylation of histones H3 and H4 in the presence of Trihostatin A, histone acetylation remained unchanged when the cells were treated without histone deacetylase inhibitor.	trihostatin a	118-131	interleukin 1 beta	Homo sapiens	26-35
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	85-87	interleukin 1 beta	Homo sapiens	209-213
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylcholines	93-112	interleukin 1 beta	Homo sapiens	209-213
19732285-6	2009	Nicotine suppresses IL-1beta and IL-6 expression at least in part by inhibiting NFkappaB activation.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	20-28
19481875-4	2009	Furthermore, the acetylcholine that secreted by vagus nerve stimulation was found to inhibit the production of such inflammatory cytokines as tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta).	Acetylcholine	17-30	interleukin 1 beta	Homo sapiens	183-200
19481875-4	2009	Furthermore, the acetylcholine that secreted by vagus nerve stimulation was found to inhibit the production of such inflammatory cytokines as tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta).	Acetylcholine	17-30	interleukin 1 beta	Homo sapiens	202-210
19845437-5	2009	The serum half-life was estimated as being between 2 and 4 h. Prednisolone exhibits near complete inhibition of the cytokines TNF-alpha, IL-1beta, IL-6 and IL-8 with very similar IC50 estimates from 0.09 to 0.16 microg ml(-1) (from 0.24 to 0.44 microM).	Prednisolone	62-74	interleukin 1 beta	Homo sapiens	137-145
19899776-7	2009	On the other hand, 1 reduced carrageenin-induced IL-1beta production as well as carrageenin-induced decrease of reduced glutathione (GSH) levels.	Carrageenan	29-40	interleukin 1 beta	Homo sapiens	49-57
19801958-0	2009	Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence.	Alcohols	80-87	interleukin 1 beta	Homo sapiens	15-20
19801958-2	2009	To confirm a previous study, we also examined the association between the IL-1B genetic polymorphism and alcohol dependence.	Alcohols	105-112	interleukin 1 beta	Homo sapiens	74-79
19801958-6	2009	CONCLUSION: This study confirms the previous finding that IL-1B polymorphism is associated with altered risk of alcohol dependence.	Alcohols	112-119	interleukin 1 beta	Homo sapiens	58-63
19820020-1	2009	OBJECTIVE: Proinflammatory cytokine IL-1beta is capable of decreasing insulin-induced glucose transport.	Glucose	86-93	interleukin 1 beta	Homo sapiens	36-44
19820020-7	2009	RESULTS: The minor allele of the IL-1beta rs1143634(G--&gt;A) was associated with higher blood glucose than the major allele: 5.37, 5.41, and 5.48 mmol/liter for the GG, AG, and AA genotypes, respectively (multivariate adjusted P for trend &lt;0.0001; Bonferroni corrected P = 0.00096).	Glucose	95-102	interleukin 1 beta	Homo sapiens	33-41
19375465-5	2009	In addition to apocynin, a known NADPH oxidase inhibitor, botanical antioxidants, such as resveratrol and epigallocatechin gallate, also inhibited IL-1beta-induced sPLA2-IIA mRNA expression.	acetovanillone	15-23	interleukin 1 beta	Homo sapiens	147-155
19375465-5	2009	In addition to apocynin, a known NADPH oxidase inhibitor, botanical antioxidants, such as resveratrol and epigallocatechin gallate, also inhibited IL-1beta-induced sPLA2-IIA mRNA expression.	Resveratrol	90-101	interleukin 1 beta	Homo sapiens	147-155
19375465-5	2009	In addition to apocynin, a known NADPH oxidase inhibitor, botanical antioxidants, such as resveratrol and epigallocatechin gallate, also inhibited IL-1beta-induced sPLA2-IIA mRNA expression.	epigallocatechin gallate	106-130	interleukin 1 beta	Homo sapiens	147-155
19561397-3	2009	The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus.	Phosphatidylcholines	22-41	interleukin 1 beta	Homo sapiens	154-162
19561397-3	2009	The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus.	Phosphatidylcholines	43-45	interleukin 1 beta	Homo sapiens	154-162
19561397-3	2009	The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus.	tricyclodecane-9-yl-xanthogenate	80-84	interleukin 1 beta	Homo sapiens	154-162
19807155-0	2009	Acteoside and 6-O-acetylacteoside downregulate cell adhesion molecules induced by IL-1beta through inhibition of ERK and JNK in human vascular endothelial cells.	acteoside	0-9	interleukin 1 beta	Homo sapiens	82-90
19878566-0	2009	Silver nanoparticles inhibit VEGF-and IL-1beta-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells.	Silver	0-6	interleukin 1 beta	Homo sapiens	38-46
19878566-1	2009	The aim of this study is to determine the effects of silver nanoparticles (Ag-NP) on vascular endothelial growth factor (VEGF)-and interleukin-1 beta (IL-1beta)-induced vascular permeability, and to detect the underlying signaling mechanisms involved in endothelial cells.	Silver	53-59	interleukin 1 beta	Homo sapiens	131-149
19878566-1	2009	The aim of this study is to determine the effects of silver nanoparticles (Ag-NP) on vascular endothelial growth factor (VEGF)-and interleukin-1 beta (IL-1beta)-induced vascular permeability, and to detect the underlying signaling mechanisms involved in endothelial cells.	Silver	53-59	interleukin 1 beta	Homo sapiens	151-159
19878566-3	2009	We found that VEGF and IL-1beta increase flux of dextran across a PRECs monolayer, and Ag-NP block solute flux induced by both VEGF and IL-1beta.	Dextrans	49-56	interleukin 1 beta	Homo sapiens	23-31
19807155-3	2009	Here, we found that acteoside, isoacteoside, and 6-O-acetylacteoside inhibited IL-1beta-activated expression of intercellular CAM-1 (ICAM-1) and vascular CAM-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs); the inhibitory potency was as follows: 6-O-acetylacteoside &gt; acteoside &gt; isoacteoside.	acteoside	34-43	interleukin 1 beta	Homo sapiens	79-87
19807155-0	2009	Acteoside and 6-O-acetylacteoside downregulate cell adhesion molecules induced by IL-1beta through inhibition of ERK and JNK in human vascular endothelial cells.	6-O-acetylacteoside	14-33	interleukin 1 beta	Homo sapiens	82-90
19807155-3	2009	Here, we found that acteoside, isoacteoside, and 6-O-acetylacteoside inhibited IL-1beta-activated expression of intercellular CAM-1 (ICAM-1) and vascular CAM-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs); the inhibitory potency was as follows: 6-O-acetylacteoside &gt; acteoside &gt; isoacteoside.	isoacteoside	300-312	interleukin 1 beta	Homo sapiens	79-87
19807155-4	2009	Acteoside and 6-O-acetylacteoside also dose-dependently inhibited VCAM-1 gene promoter activity in IL-1beta-activated HUVECs.	acteoside	0-9	interleukin 1 beta	Homo sapiens	99-107
19807155-4	2009	Acteoside and 6-O-acetylacteoside also dose-dependently inhibited VCAM-1 gene promoter activity in IL-1beta-activated HUVECs.	6-O-acetylacteoside	14-33	interleukin 1 beta	Homo sapiens	99-107
19807155-3	2009	Here, we found that acteoside, isoacteoside, and 6-O-acetylacteoside inhibited IL-1beta-activated expression of intercellular CAM-1 (ICAM-1) and vascular CAM-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs); the inhibitory potency was as follows: 6-O-acetylacteoside &gt; acteoside &gt; isoacteoside.	acteoside	20-29	interleukin 1 beta	Homo sapiens	79-87
19807155-5	2009	The inhibition of acteoside and 6-O-acetylacteoside on IL-1beta-activated expression of CAMs was manifested by decreased phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK).	acteoside	18-27	interleukin 1 beta	Homo sapiens	55-63
19807155-5	2009	The inhibition of acteoside and 6-O-acetylacteoside on IL-1beta-activated expression of CAMs was manifested by decreased phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK).	6-O-acetylacteoside	32-51	interleukin 1 beta	Homo sapiens	55-63
19807155-3	2009	Here, we found that acteoside, isoacteoside, and 6-O-acetylacteoside inhibited IL-1beta-activated expression of intercellular CAM-1 (ICAM-1) and vascular CAM-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs); the inhibitory potency was as follows: 6-O-acetylacteoside &gt; acteoside &gt; isoacteoside.	isoacteoside	31-43	interleukin 1 beta	Homo sapiens	79-87
19807155-3	2009	Here, we found that acteoside, isoacteoside, and 6-O-acetylacteoside inhibited IL-1beta-activated expression of intercellular CAM-1 (ICAM-1) and vascular CAM-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs); the inhibitory potency was as follows: 6-O-acetylacteoside &gt; acteoside &gt; isoacteoside.	6-O-acetylacteoside	49-68	interleukin 1 beta	Homo sapiens	79-87
19807155-3	2009	Here, we found that acteoside, isoacteoside, and 6-O-acetylacteoside inhibited IL-1beta-activated expression of intercellular CAM-1 (ICAM-1) and vascular CAM-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs); the inhibitory potency was as follows: 6-O-acetylacteoside &gt; acteoside &gt; isoacteoside.	6-O-acetylacteoside	260-279	interleukin 1 beta	Homo sapiens	79-87
19805629-10	2009	Therefore, glyburide is the first identified compound to prevent Cryopyrin activation and microbial ligand-, DAMP-, and crystal-induced IL-1beta secretion.	Glyburide	11-20	interleukin 1 beta	Homo sapiens	136-144
19648113-10	2009	IL-1beta facilitates the dissociation of histone deacetylase (HDAC)-1/2 from the PDGF-R alpha promoter, whereas the HDAC inhibitors suberoylanilide hydroxamic acid and trichostatin A potentiate IL-1beta induction of PDGF-R alpha transcription.	Vorinostat	132-163	interleukin 1 beta	Homo sapiens	194-202
19648113-10	2009	IL-1beta facilitates the dissociation of histone deacetylase (HDAC)-1/2 from the PDGF-R alpha promoter, whereas the HDAC inhibitors suberoylanilide hydroxamic acid and trichostatin A potentiate IL-1beta induction of PDGF-R alpha transcription.	trichostatin A	168-182	interleukin 1 beta	Homo sapiens	194-202
19551451-0	2009	Transforming growth factor-beta1 (TGF-beta1) and acetylcholine (ACh) alter nitric oxide (NO) and interleukin-1beta (IL-1beta) secretion in human colon adenocarcinoma cells.	Acetylcholine	49-62	interleukin 1 beta	Homo sapiens	97-114
19446813-4	2009	Digitoxin, employing therapeutical concentrations used in patients (3-30nM), potently inhibited the IL-1beta-induced expression of MCP-1 and VCAM-1 in EC and the capacity of corresponding cell culture supernatants on monocyte migration as well as monocyte adhesion to endothelial monolayers, respectively.	Digitoxin	0-9	interleukin 1 beta	Homo sapiens	100-108
19446813-5	2009	Furthermore, digitoxin prevented the IL-1beta-induced activation of p44/42-MAPK and NF-kappaB without affecting activation of JNK and p38-MAPK.	Digitoxin	13-22	interleukin 1 beta	Homo sapiens	37-45
19577291-6	2009	After 6 and 18 h of incubation HA and beta-TCP caused a quite similar induction of TNF-alpha, IL-1beta and IL-8.	beta-tricalcium phosphate	38-46	interleukin 1 beta	Homo sapiens	94-102
19551451-0	2009	Transforming growth factor-beta1 (TGF-beta1) and acetylcholine (ACh) alter nitric oxide (NO) and interleukin-1beta (IL-1beta) secretion in human colon adenocarcinoma cells.	Acetylcholine	49-62	interleukin 1 beta	Homo sapiens	116-124
19551451-0	2009	Transforming growth factor-beta1 (TGF-beta1) and acetylcholine (ACh) alter nitric oxide (NO) and interleukin-1beta (IL-1beta) secretion in human colon adenocarcinoma cells.	Acetylcholine	64-67	interleukin 1 beta	Homo sapiens	97-114
19551451-0	2009	Transforming growth factor-beta1 (TGF-beta1) and acetylcholine (ACh) alter nitric oxide (NO) and interleukin-1beta (IL-1beta) secretion in human colon adenocarcinoma cells.	Acetylcholine	64-67	interleukin 1 beta	Homo sapiens	116-124
19551451-6	2009	ACh exhibited significant inhibitory effects towards NO, endothelial nitric oxide synthase (eNOS), and IL-1beta secretion especially by tumor cells derived form Duke"s C stage of colon carcinoma.	Acetylcholine	0-3	interleukin 1 beta	Homo sapiens	103-111
19333723-0	2009	Interleukin-1 beta and tumor necrosis factor-alpha increase ABCG2 expression in MCF-7 breast carcinoma cell line and its mitoxantrone-resistant derivative, MCF-7/MX.	Mitoxantrone	121-133	interleukin 1 beta	Homo sapiens	0-50
19626664-0	2009	Glucosamine inhibits IL-1beta-mediated IL-8 production in prostate cancer cells by MAPK attenuation.	Glucosamine	0-11	interleukin 1 beta	Homo sapiens	21-29
19626664-4	2009	Glucosamine is widely regarded as an anti-inflammatory agent and thus we hypothesized that if IL-1beta activated IL-8 production in prostate cancer cells, then glucosamine ought to blunt such an effect.	Glucosamine	0-11	interleukin 1 beta	Homo sapiens	94-102
19626664-7	2009	Glucosamine significantly inhibited IL-1beta-induced IL-8 secretion.	Glucosamine	0-11	interleukin 1 beta	Homo sapiens	36-44
19626664-10	2009	IL-1beta-provoked phosphorylation of all MAPKs was notably suppressed by glucosamine.	Glucosamine	73-84	interleukin 1 beta	Homo sapiens	0-8
19626664-12	2009	In this context, glucosamine appears to inhibit IL-1beta-mediated activation of MAPKs and therefore reduces IL-8 production; this, in turn, attenuates cell proliferation/migration.	Glucosamine	17-28	interleukin 1 beta	Homo sapiens	48-56
19696060-9	2009	Prednisone treatment induced remission of clinical symptoms and normalized IL-1beta secretion and P2X(7) and ASC expression.	Prednisone	0-10	interleukin 1 beta	Homo sapiens	75-83
19745762-10	2009	Gangliosides suppressed infant bowel production of nitric oxide, leukotriene B4, prostaglandin E2, hydrogen peroxide, interleukin-1beta, interleukin-6, and interleukin-8 in response to LPS exposure and hypoxia.	Gangliosides	0-12	interleukin 1 beta	Homo sapiens	118-135
19656660-5	2009	OBJECTIVE: We evaluated whether GS-HCl modulates expression of COX-2 and/or MMPs by IL-1beta or PMA in human skin fibroblasts (HSF) or keratinocytes (HaCaT).	gs-hcl	32-38	interleukin 1 beta	Homo sapiens	84-92
19656660-11	2009	Of interest, treatment with GS-HCl (10mM) led to blockage of p38 MAPK activation, accumulation of 66kDa COX-2 protein variant (without affecting COX-2 mRNA expression), and transcriptional down-regulation of MMP-13 in the IL-1beta- or PMA-treated HSF cells.	gs-hcl	28-34	interleukin 1 beta	Homo sapiens	222-230
19656660-12	2009	Distinctly, pharmacological inhibition of p38 MAPK with SB203580 was associated with transcriptional down-regulation of COX-2 and MMP-13 in the IL-1beta- or PMA-treated HSF cells.	SB 203580	56-64	interleukin 1 beta	Homo sapiens	144-152
19656660-14	2009	CONCLUSIONS: GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively.	gs-hcl	13-19	interleukin 1 beta	Homo sapiens	85-93
19951554-6	2009	Serum contents of TNF-alpha and IL-1beta in L-arginine 400 mg group were close to those of control group (P &gt; 0.05).	Arginine	44-54	interleukin 1 beta	Homo sapiens	32-40
19580863-0	2009	Role of IL-1 beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures.	Silicon Dioxide	30-36	interleukin 1 beta	Homo sapiens	8-17
19580863-1	2009	The pro-inflammatory cytokines IL-1 beta, TNF-alpha and IL-6 are of great importance in the development of silica-induced lung damage and repair.	Silicon Dioxide	107-113	interleukin 1 beta	Homo sapiens	31-40
19580863-2	2009	In this study we investigated the role of IL-1 beta, TNF-alpha and COX2 in silica-induced regulation of IL-6 release and pneumocyte loss in various mono- and co-cultures of monocytes, pneumocytes and endothelial cells.	Silicon Dioxide	75-81	interleukin 1 beta	Homo sapiens	42-51
19580863-8	2009	Silica-induced pneumocyte loss was reduced by IL-1 beta, but this effect was not counteracted by the IL-1 receptor antagonist.	Silicon Dioxide	0-6	interleukin 1 beta	Homo sapiens	46-55
19580863-9	2009	Our findings suggest that silica-induced IL-6 release from pneumocytes is mainly mediated via IL-1 beta release from the monocytes, via both COX2-dependent and -independent pathways.	Silicon Dioxide	26-32	interleukin 1 beta	Homo sapiens	94-103
19616541-0	2009	An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation.	N-chlorotaurine	105-123	interleukin 1 beta	Homo sapiens	182-190
19592498-0	2009	Pro-interleukin (IL)-1beta shares a core region of stability as compared with mature IL-1beta while maintaining a distinctly different configurational landscape: a comparative hydrogen/deuterium exchange mass spectrometry study.	Hydrogen	176-184	interleukin 1 beta	Homo sapiens	0-26
19592498-0	2009	Pro-interleukin (IL)-1beta shares a core region of stability as compared with mature IL-1beta while maintaining a distinctly different configurational landscape: a comparative hydrogen/deuterium exchange mass spectrometry study.	Deuterium	185-194	interleukin 1 beta	Homo sapiens	0-26
19616541-0	2009	An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation.	Taurine	34-41	interleukin 1 beta	Homo sapiens	182-190
19616541-0	2009	An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation.	Mesalamine	53-74	interleukin 1 beta	Homo sapiens	182-190
19616541-0	2009	An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation.	Mesalamine	157-178	interleukin 1 beta	Homo sapiens	182-190
19616541-6	2009	Treatment with either 5-ASA or taurine chloramine (TauCl) inhibited IL-1beta-mediated NFkappaB dependent luciferase expression and IL-6 secretion.	Mesalamine	22-27	interleukin 1 beta	Homo sapiens	68-76
19616541-6	2009	Treatment with either 5-ASA or taurine chloramine (TauCl) inhibited IL-1beta-mediated NFkappaB dependent luciferase expression and IL-6 secretion.	N-chlorotaurine	31-49	interleukin 1 beta	Homo sapiens	68-76
19616541-6	2009	Treatment with either 5-ASA or taurine chloramine (TauCl) inhibited IL-1beta-mediated NFkappaB dependent luciferase expression and IL-6 secretion.	N-chlorotaurine	51-56	interleukin 1 beta	Homo sapiens	68-76
19616541-7	2009	In HCT116 cells, the inhibitory effect by TauCl or 5-ASA was through preventing IL-1beta-induced IkappaB kinase activation and subsequently interfering with IkappaBalpha degradation and p65 nuclear accumulation.	N-chlorotaurine	42-47	interleukin 1 beta	Homo sapiens	80-88
19616541-7	2009	In HCT116 cells, the inhibitory effect by TauCl or 5-ASA was through preventing IL-1beta-induced IkappaB kinase activation and subsequently interfering with IkappaBalpha degradation and p65 nuclear accumulation.	Mesalamine	51-56	interleukin 1 beta	Homo sapiens	80-88
19616541-8	2009	Furthermore, combined TauCl/5-ASA treatment interfered additively with the activation process, leading to additive inhibitory effect on IL-1beta-mediated NFkappaB activation.	N-chlorotaurine	22-27	interleukin 1 beta	Homo sapiens	136-144
19616541-8	2009	Furthermore, combined TauCl/5-ASA treatment interfered additively with the activation process, leading to additive inhibitory effect on IL-1beta-mediated NFkappaB activation.	Mesalamine	28-33	interleukin 1 beta	Homo sapiens	136-144
19467228-4	2009	The release of sEPCR induced by IL-1beta and TNF-alpha correlated with activation of p38 MAPK and c-Jun N-terminal kinase (JNK).	sepcr	15-20	interleukin 1 beta	Homo sapiens	32-40
19751497-0	2009	Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	48-56
19520550-8	2009	In patients taking valproate (VPA, n=9), the levels of IL-1beta were higher as compared to patients not treated with VPA.	Valproic Acid	19-28	interleukin 1 beta	Homo sapiens	55-63
19751497-0	2009	Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells.	Prostaglandins	21-34	interleukin 1 beta	Homo sapiens	48-56
19751497-6	2009	In the present study, we investigated the effects of resveratrol on interleukin (IL)-1beta stimulated SK-N-SH cells.	Resveratrol	53-64	interleukin 1 beta	Homo sapiens	68-90
19520550-8	2009	In patients taking valproate (VPA, n=9), the levels of IL-1beta were higher as compared to patients not treated with VPA.	Valproic Acid	30-33	interleukin 1 beta	Homo sapiens	55-63
19520550-8	2009	In patients taking valproate (VPA, n=9), the levels of IL-1beta were higher as compared to patients not treated with VPA.	Valproic Acid	117-120	interleukin 1 beta	Homo sapiens	55-63
19740320-4	2009	In vitro culturing of muscle cells with the proinflammatory cytokines interferon-gamma, tumour necrosis factor-alpha, and interleukin (IL)-1beta synergistically increased Fas expression, susceptibility to Fas-mediated apoptosis, and the expression of cytoplasmic caspases 8 and 3.	ammonium ferrous sulfate	171-174	interleukin 1 beta	Homo sapiens	122-144
19825518-6	2009	In this review, we discuss recent reports demonstrating that in vitro inhibition of the mevalonate pathway by statins specifically increases the production, by activated monocytes, of cytokines of the IL-1 family, by enhancing caspase-1 activity, the enzyme responsible for IL-1beta and IL-18 maturation.	Mevalonic Acid	88-98	interleukin 1 beta	Homo sapiens	274-282
19825520-7	2009	RESULTS: Pharmacological inhibition of the mevalonate pathway specifically enhanced the release of IL-1alpha, IL-1beta and IL-18 and inhibited IL-1ra production by LPS-activated PBMCs and THP-1 cells.	Mevalonic Acid	43-53	interleukin 1 beta	Homo sapiens	110-118
19825520-8	2009	Simvastatin did not modify pro-IL-1beta expression, but enhanced caspase-1 activity, the enzyme responsible for IL-1beta and IL-18 maturation.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	112-120
19825520-11	2009	CONCLUSION: Pharmacological inhibition of the mevalonate pathway by statins highlighted the specific induction of the proinflammatory cytokines of the IL-1 family whose maturation is either directly (i.e. IL-1beta and IL-18), or indirectly (i.e. IL-1alpha) dependant on caspase-1.	Mevalonic Acid	46-56	interleukin 1 beta	Homo sapiens	205-213
19290479-1	2009	OBJECTIVE: To identify the molecular mechanisms of bucillamine activity, global gene expression analysis and pathway analysis were conducted using IL-1 beta-stimulated human fibroblast-like synovial cells (FLS).	bucillamine	51-62	interleukin 1 beta	Homo sapiens	147-156
19290479-5	2009	At both concentrations, bucillamine suppressed nine signal pathways stimulated by IL-1 beta.	bucillamine	24-35	interleukin 1 beta	Homo sapiens	82-91
19290479-6	2009	CONCLUSIONS: Bucillamine effectively inhibited fibroblast growth factor (FGF) signaling and tight junction signaling activated by IL-1 beta in FLS.	bucillamine	13-24	interleukin 1 beta	Homo sapiens	130-139
19290480-6	2009	A positive association was found between the subpopulation of CD14(+)CD16(+) monocytes and plasma TNF-alpha and IL-1 beta level in AL patients.	Aluminum	131-133	interleukin 1 beta	Homo sapiens	112-121
19740321-7	2009	Additionally, poly(I:C) affected IL-1beta production and the migratory behaviour of Detroit-562.	Poly I-C	14-22	interleukin 1 beta	Homo sapiens	33-41
19740321-9	2009	Poly(I:C) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam(3)CSK(4) increased viability.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	38-46
19723873-9	2009	Phosphorylation of CEBPB at Thr(235) peaked at 16 hours in IL-1beta-stimulated cells.	Threonine	28-31	interleukin 1 beta	Homo sapiens	59-67
19779119-9	2009	Indeed, administration of neoadjuvant TAS appeared to bring about a marked elevation of IL-1beta and IL-6 and a significant reduction in TGFbeta when compared to patients receiving xRT alone.	tas	38-41	interleukin 1 beta	Homo sapiens	88-96
19779119-10	2009	CONCLUSION: The precise mechanisms underlying this TAS-related increase of the proinflammatory cytokines IL-1beta and IL-6 and decrease of the profibrotic cytokine TGFbeta remain unclear.	tas	51-54	interleukin 1 beta	Homo sapiens	105-113
19776509-1	2009	Interleukin-1beta (IL-1beta) stimulates expression of the highly inducible enzyme cyclooxygenase-2 (COX-2) via activation of nuclear factor kappaB (NFkappaB), and consequently provokes prostaglandin E(2) (PGE(2)) synthesis, which induces inflammatory responses.	Dinoprostone	185-203	interleukin 1 beta	Homo sapiens	0-17
19776509-1	2009	Interleukin-1beta (IL-1beta) stimulates expression of the highly inducible enzyme cyclooxygenase-2 (COX-2) via activation of nuclear factor kappaB (NFkappaB), and consequently provokes prostaglandin E(2) (PGE(2)) synthesis, which induces inflammatory responses.	Dinoprostone	185-203	interleukin 1 beta	Homo sapiens	19-27
19776509-1	2009	Interleukin-1beta (IL-1beta) stimulates expression of the highly inducible enzyme cyclooxygenase-2 (COX-2) via activation of nuclear factor kappaB (NFkappaB), and consequently provokes prostaglandin E(2) (PGE(2)) synthesis, which induces inflammatory responses.	Prostaglandins E	205-208	interleukin 1 beta	Homo sapiens	0-17
19776509-1	2009	Interleukin-1beta (IL-1beta) stimulates expression of the highly inducible enzyme cyclooxygenase-2 (COX-2) via activation of nuclear factor kappaB (NFkappaB), and consequently provokes prostaglandin E(2) (PGE(2)) synthesis, which induces inflammatory responses.	Prostaglandins E	205-208	interleukin 1 beta	Homo sapiens	19-27
19776509-2	2009	In this study, the contribution of protein kinase C (PKC) to IL-1beta-induced PGE(2) synthesis in human gingival fibroblasts was investigated.	Dinoprostone	78-84	interleukin 1 beta	Homo sapiens	61-69
19776509-3	2009	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta.	Tetradecanoylphorbol Acetate	18-49	interleukin 1 beta	Homo sapiens	162-170
19776509-3	2009	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta.	Tetradecanoylphorbol Acetate	51-54	interleukin 1 beta	Homo sapiens	162-170
19776509-3	2009	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta.	Dinoprostone	67-73	interleukin 1 beta	Homo sapiens	162-170
19776509-5	2009	In cells in which PMA-dependent PKC was down-regulated, PMA failed to induce the formation of NFkappaB DNA-protein complex and reduced the release of PMA-induced PGE(2), whereas IL-1beta stimulated the formation of COX-2-NFkappaB DNA-protein complex and PGE(2) release.	Tetradecanoylphorbol Acetate	18-21	interleukin 1 beta	Homo sapiens	178-186
19839866-3	2009	RESULTS: Under high glucose conditions, interleukin-1beta significantly increased expression of c-Jun and decreased the expression of glutamine synthetase.	Glucose	20-27	interleukin 1 beta	Homo sapiens	40-57
19776509-6	2009	The atypical PKC (aPKC) inhibitor Go6983 clearly suppressed the formation of COX-2-NFkappaB DNA-protein complex and PGE(2) release stimulated by IL-1beta but not the inhibitor of conventional PKC (cPKC) and the novel PKC (nPKC) inhibitor Go6976.	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	34-40	interleukin 1 beta	Homo sapiens	145-153
19776509-6	2009	The atypical PKC (aPKC) inhibitor Go6983 clearly suppressed the formation of COX-2-NFkappaB DNA-protein complex and PGE(2) release stimulated by IL-1beta but not the inhibitor of conventional PKC (cPKC) and the novel PKC (nPKC) inhibitor Go6976.	Prostaglandins E	116-119	interleukin 1 beta	Homo sapiens	145-153
19776509-6	2009	The atypical PKC (aPKC) inhibitor Go6983 clearly suppressed the formation of COX-2-NFkappaB DNA-protein complex and PGE(2) release stimulated by IL-1beta but not the inhibitor of conventional PKC (cPKC) and the novel PKC (nPKC) inhibitor Go6976.	Go 6976	238-244	interleukin 1 beta	Homo sapiens	145-153
19776509-7	2009	These observations suggest that aPKC is involved in IL-1beta-induced PGE(2) synthesis, which is controlled by transcription of the COX-2 gene via the NFkappaB-dependent pathway in human gingival fibroblasts.	Prostaglandins E	69-72	interleukin 1 beta	Homo sapiens	52-60
19802674-10	2009	IL-1beta strongly increased the translocation of NF-kappaB to the nucleus and the phosphorylation of extracellular-signal-regulated kinase, p38, and c-Jun amino-terminal kinase; but the up-regulation was not inhibited by DEX or COX inhibitors.	Dexamethasone	221-224	interleukin 1 beta	Homo sapiens	0-8
19651324-12	2009	Additionally, SM upregulates many inflammatory mediators including interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and others.	Mustard Gas	14-16	interleukin 1 beta	Homo sapiens	92-100
19724980-10	2009	Both acupuncture and fluoxetine treatments, but not the placebo, reduced IL-1beta concentrations in responders.	Fluoxetine	21-31	interleukin 1 beta	Homo sapiens	73-81
19724980-13	2009	Both EA and fluoxetine had an anti-inflammatory effect by reducing IL-1beta.	Fluoxetine	12-22	interleukin 1 beta	Homo sapiens	67-75
19564644-7	2009	Medroxyprogesterone acetate significantly suppressed LPS-induced production of interleukin 1b (IL-1b), IL-6, and IL-8 in vitro (P &lt; .05).	Medroxyprogesterone Acetate	0-27	interleukin 1 beta	Homo sapiens	79-93
19564644-7	2009	Medroxyprogesterone acetate significantly suppressed LPS-induced production of interleukin 1b (IL-1b), IL-6, and IL-8 in vitro (P &lt; .05).	Medroxyprogesterone Acetate	0-27	interleukin 1 beta	Homo sapiens	95-100
18982426-0	2009	Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	19-28
18982426-5	2009	In this study, the inhibitory effect of quercetin on ICAM-1 expression by interleukin-1 beta (IL-1 beta)-stimulated A549 cells was investigated, and the roles of mitogen-activated protein kinases (MAPK) pathways were explored.	Quercetin	40-49	interleukin 1 beta	Homo sapiens	74-92
18982426-5	2009	In this study, the inhibitory effect of quercetin on ICAM-1 expression by interleukin-1 beta (IL-1 beta)-stimulated A549 cells was investigated, and the roles of mitogen-activated protein kinases (MAPK) pathways were explored.	Quercetin	40-49	interleukin 1 beta	Homo sapiens	94-103
18982426-6	2009	Quercetin attenuated IL-1 beta-induced expression of ICAM-1 mRNA and protein in a dose-dependent manner.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	21-30
19381066-0	2009	Lysophosphatidylglycerol inhibits formyl peptide receptorlike-1-stimulated chemotactic migration and IL-1beta production from human phagocytes.	lysophosphatidylglycerol	0-24	interleukin 1 beta	Homo sapiens	101-109
19660121-10	2009	IL-1beta and the NO donor diethylenetriamine/nitric oxide (DETA/NO) elevated PGE2 release by satellite cells.	Dinoprostone	77-81	interleukin 1 beta	Homo sapiens	0-8
19558546-7	2009	KEY RESULTS: BGMP up-regulated the secretion of TNF, IL-1beta and IL-8 in a concentration-dependent fashion.	bgmp	13-17	interleukin 1 beta	Homo sapiens	53-61
19723085-6	2009	We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells.	Fatty Acids, Omega-3	14-33	interleukin 1 beta	Homo sapiens	155-163
19723085-6	2009	We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells.	Docosahexaenoic Acids	43-63	interleukin 1 beta	Homo sapiens	155-163
19723085-6	2009	We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells.	Docosahexaenoic Acids	65-68	interleukin 1 beta	Homo sapiens	155-163
19723085-6	2009	We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells.	alpha-Linolenic Acid	74-94	interleukin 1 beta	Homo sapiens	155-163
19723085-6	2009	We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells.	alpha-Linolenic Acid	96-99	interleukin 1 beta	Homo sapiens	155-163
19558546-9	2009	The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	68-75	interleukin 1 beta	Homo sapiens	44-52
19558546-9	2009	The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38.	pyrazolanthrone	77-85	interleukin 1 beta	Homo sapiens	44-52
19558546-9	2009	The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38.	SB 203580	87-95	interleukin 1 beta	Homo sapiens	44-52
19406240-7	2009	GR function was assessed by measuring the inhibitory effect of dexamethasone on constitutive and IL-1beta-inducible IL-6 and osteoprotegerin (OPG) production.	Dexamethasone	63-76	interleukin 1 beta	Homo sapiens	97-105
20141611-5	2009	However, among the three compounds tested, only THS-78-5 protected against IL-1beta-mediated loss in beta-cell viability.	Thorium	48-51	interleukin 1 beta	Homo sapiens	75-83
20141611-6	2009	THS-78-5 was also able to attenuate IL-1beta-induced inducible nitric oxide synthase expression and subsequent NO release.	Thorium	0-3	interleukin 1 beta	Homo sapiens	36-44
20141611-7	2009	Our data also indicate that the cytoprotective properties of THS-78-5 against IL-1beta-mediated effects may, in part, be due to inhibition of IL-1beta-induced transactivation of nuclear factor kappaB (NF-kappaB) in these cells.	Thorium	61-64	interleukin 1 beta	Homo sapiens	78-86
20141611-7	2009	Our data also indicate that the cytoprotective properties of THS-78-5 against IL-1beta-mediated effects may, in part, be due to inhibition of IL-1beta-induced transactivation of nuclear factor kappaB (NF-kappaB) in these cells.	Thorium	61-64	interleukin 1 beta	Homo sapiens	142-150
19596994-3	2009	We identify 7-bromoindirubin-3"-oxime, an indirubin oxime derivative that induces necrosis, as a potent inducer of caspase-1 activation and release of mature IL-1beta and IL-18.	7-bromoindirubin-3'-oxime	12-37	interleukin 1 beta	Homo sapiens	158-166
19596994-3	2009	We identify 7-bromoindirubin-3"-oxime, an indirubin oxime derivative that induces necrosis, as a potent inducer of caspase-1 activation and release of mature IL-1beta and IL-18.	indirubin oxime	42-57	interleukin 1 beta	Homo sapiens	158-166
19435930-3	2009	Analysis with IkappaBalphaDeltaN, a dominant version of inhibitor of kappaBalpha (IkappaBalpha), as well as dominant-negative and small-molecule IkappaB kinase (IKK) inhibitors demonstrated that IL-1beta-induced TTP is nuclear factor-kappaB (NF-kappaB)-dependent.	ikappabalphadeltan	14-32	interleukin 1 beta	Homo sapiens	195-203
19435930-6	2009	In the context of IL-1beta, dexamethasone exerted a marginal repressive effect on TTP mRNA expression and more considerably reduced TTP protein.	Dexamethasone	28-41	interleukin 1 beta	Homo sapiens	18-26
19435930-7	2009	Given a requirement for p38 MAPK in the induction of TTP by IL-1beta, this repressive effect may be explained by repression of the p38 MAPK pathway by dexamethasone.	Dexamethasone	151-164	interleukin 1 beta	Homo sapiens	60-68
19406240-8	2009	In PC-3 cells, IL-1beta stimulated IL-6 and OPG release, and dexamethasone dose-dependently inhibited IL-1beta-inducible IL-6 release, and constitutive and IL-1beta-inducible OPG release.	Dexamethasone	61-74	interleukin 1 beta	Homo sapiens	102-110
19406240-8	2009	In PC-3 cells, IL-1beta stimulated IL-6 and OPG release, and dexamethasone dose-dependently inhibited IL-1beta-inducible IL-6 release, and constitutive and IL-1beta-inducible OPG release.	Dexamethasone	61-74	interleukin 1 beta	Homo sapiens	102-110
19406240-10	2009	While dexamethasone was ineffective, cortisol dose-dependently inhibited IL-1beta-inducible OPG release.	Hydrocortisone	37-45	interleukin 1 beta	Homo sapiens	73-81
19233337-12	2009	Interleukin (IL)-1beta significantly altered glutamate release and uptake (about 90% increase and 50% decrease, respectively, in SW1353 cells).	Glutamic Acid	45-54	interleukin 1 beta	Homo sapiens	0-22
19659928-6	2009	In addition, this cell death was induced not only by DENV itself, but also by the apoptotic activities of pro-inflammatory cytokines, such as TNF-alpha, and IL-1beta, that were upregulated in DHF patients.	dhf	192-195	interleukin 1 beta	Homo sapiens	157-165
19557821-3	2009	Our results show that all flavonoids significantly inhibited HG-induced expression of proinflammatory genes and proteins, including TNF-alpha, interleukin-1beta (IL-1beta), and cyclooxygenase (COX)-2, at a concentration of 20 microM.	Flavonoids	26-36	interleukin 1 beta	Homo sapiens	143-160
19557821-3	2009	Our results show that all flavonoids significantly inhibited HG-induced expression of proinflammatory genes and proteins, including TNF-alpha, interleukin-1beta (IL-1beta), and cyclooxygenase (COX)-2, at a concentration of 20 microM.	Flavonoids	26-36	interleukin 1 beta	Homo sapiens	162-170
19332174-11	2009	In IL-1beta-stimulated chondrocytes, GlcN inhibits membrane translocation of GLUT1 and 6, but does not affect the expression of GLUT3.	Glucosamine	37-41	interleukin 1 beta	Homo sapiens	3-11
19561107-3	2009	ROS production and antioxidant response are both required, because either inhibitors of NADPH oxidase and of thioredoxin reductase impair IL-1beta secretion.	Reactive Oxygen Species	0-3	interleukin 1 beta	Homo sapiens	138-146
19557430-7	2009	Our findings show that (1) VSMC of progressive atheromas have the ability of differentiation, (2) that transdifferentiation and dedifferentiation phenomena are topographically diverse localized in the subregions of advanced atherosclerotic lesions, and (3) are influenced by inflammatory cytokines like IL-1beta, IL-6, and TNF-alpha.	vsmc	27-31	interleukin 1 beta	Homo sapiens	303-311
19536133-0	2009	Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates.	Diphosphates	93-107	interleukin 1 beta	Homo sapiens	68-76
19536133-1	2009	In acute inflammation, extracellular ATP activates P2X(7) ion channel receptors (P2X(7)R) on M1 polarized macrophages to release pro-inflammatory IL-1beta through activation of the caspase-1/nucleotide-binding domain and leucine-rich repeat receptor containing pyrin domain 3 (NLRP3) inflammasome.	Adenosine Triphosphate	37-40	interleukin 1 beta	Homo sapiens	146-154
19536133-5	2009	In these intermediate M1/M2 polarized macrophages, extracellular ATP now acts through its pyrophosphate chains, independently of other purine receptors, to inhibit IL-1beta release by other stimuli through two independent mechanisms: inhibition of ROS production and trapping of the inflammasome complex through intracellular clustering of actin filaments.	Adenosine Triphosphate	65-68	interleukin 1 beta	Homo sapiens	164-172
19536133-5	2009	In these intermediate M1/M2 polarized macrophages, extracellular ATP now acts through its pyrophosphate chains, independently of other purine receptors, to inhibit IL-1beta release by other stimuli through two independent mechanisms: inhibition of ROS production and trapping of the inflammasome complex through intracellular clustering of actin filaments.	diphosphoric acid	90-103	interleukin 1 beta	Homo sapiens	164-172
19525014-3	2009	The anti-GM1 Ab-treated SC also showed increased release of pro-inflammation cytokines IL-1beta and TNF-alpha after incubation with lipopolysaccharide (LPS).	G(M1) Ganglioside	9-12	interleukin 1 beta	Homo sapiens	87-95
19953908-6	2009	ROK inhibitor Y27632 reduced the secretion of TNFalpha, IL-1beta and IL-6 in RA SF monocytic cells, but had no effect upon the secretion of IL-10, an anti-inflammatory cytokine.	Y 27632	14-20	interleukin 1 beta	Homo sapiens	56-64
19561107-5	2009	Not only silencing of thioredoxin, but also of the ROS scavenger superoxide dismutase 1 results in inhibition of IL-1beta secretion.	Reactive Oxygen Species	51-54	interleukin 1 beta	Homo sapiens	113-121
19561107-6	2009	Thus, PAMP-induced ROS trigger an antioxidant response involving intracellular redox enzymes and release of cysteine, ultimately required for IL-1beta processing and secretion.	Reactive Oxygen Species	19-22	interleukin 1 beta	Homo sapiens	142-150
19561107-6	2009	Thus, PAMP-induced ROS trigger an antioxidant response involving intracellular redox enzymes and release of cysteine, ultimately required for IL-1beta processing and secretion.	Cysteine	108-116	interleukin 1 beta	Homo sapiens	142-150
19255163-8	2009	In addition, patients with DTS had significantly higher levels of IL-1beta, IL-6, TNF-alpha, and TGF-beta1 mRNA transcripts in their conjunctival epithelia than did the control subjects.	dibenzyl trisulfide	27-30	interleukin 1 beta	Homo sapiens	66-74
19542372-5	2009	In addition to TNF-alpha, IL-1alpha and IL-1beta promoted caspase-1 activation via Nlrp3 in response to ATP.	Adenosine Triphosphate	104-107	interleukin 1 beta	Homo sapiens	40-48
19339710-3	2009	We manipulated actin dynamics with jasplakinolide (100 nM) and latrunculin B (1 microM), both of which significantly inhibited the synthesis of decidualization markers induced by 6 days of treatment with embryo-mimicking stimulus interleukin 1beta (IL1B) and steroid hormones (SHs; 17beta-estradiol and medroxyprogesterone acetate) in the human uterine fibroblast (HuF) in vitro model.	jasplakinolide	35-49	interleukin 1 beta	Homo sapiens	230-247
19339710-3	2009	We manipulated actin dynamics with jasplakinolide (100 nM) and latrunculin B (1 microM), both of which significantly inhibited the synthesis of decidualization markers induced by 6 days of treatment with embryo-mimicking stimulus interleukin 1beta (IL1B) and steroid hormones (SHs; 17beta-estradiol and medroxyprogesterone acetate) in the human uterine fibroblast (HuF) in vitro model.	jasplakinolide	35-49	interleukin 1 beta	Homo sapiens	249-253
19339710-3	2009	We manipulated actin dynamics with jasplakinolide (100 nM) and latrunculin B (1 microM), both of which significantly inhibited the synthesis of decidualization markers induced by 6 days of treatment with embryo-mimicking stimulus interleukin 1beta (IL1B) and steroid hormones (SHs; 17beta-estradiol and medroxyprogesterone acetate) in the human uterine fibroblast (HuF) in vitro model.	latrunculin B	63-76	interleukin 1 beta	Homo sapiens	230-247
19339710-3	2009	We manipulated actin dynamics with jasplakinolide (100 nM) and latrunculin B (1 microM), both of which significantly inhibited the synthesis of decidualization markers induced by 6 days of treatment with embryo-mimicking stimulus interleukin 1beta (IL1B) and steroid hormones (SHs; 17beta-estradiol and medroxyprogesterone acetate) in the human uterine fibroblast (HuF) in vitro model.	latrunculin B	63-76	interleukin 1 beta	Homo sapiens	249-253
19671252-0	2009	[6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells.	gingerol	4-12	interleukin 1 beta	Homo sapiens	24-42
19671252-2	2009	The present study investigated whether [6]-gingerol suppresses interleukin (IL)-1 beta-induced MUC5AC gene expression in human airway epithelial cells and, if so, examined whether the suppression of MUC5AC gene expression is mediated via the mitogen-activated protein kinase (MAPK) signal transduction pathway.	gingerol	39-51	interleukin 1 beta	Homo sapiens	63-86
19671252-6	2009	When the cells were pretreated with 10 microM of [6]-gingerol, expression of IL-1 beta-induced MUC5AC mRNA and protein was significantly suppressed.	gingerol	49-61	interleukin 1 beta	Homo sapiens	77-86
19671252-7	2009	Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways.	gingerol	146-154	interleukin 1 beta	Homo sapiens	15-24
19671252-7	2009	Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways.	gingerol	146-154	interleukin 1 beta	Homo sapiens	179-188
19671252-8	2009	CONCLUSIONS: [6]-Gingerol suppresses IL-1 beta -induced MUC5AC gene expression in human airway epithelial cells via the ERK- and p38 MAPK-dependent pathways; therefore, [6]-gingerol may be considered a possible anti-hypersecretory agent.	gingerol	17-25	interleukin 1 beta	Homo sapiens	37-46
19671252-8	2009	CONCLUSIONS: [6]-Gingerol suppresses IL-1 beta -induced MUC5AC gene expression in human airway epithelial cells via the ERK- and p38 MAPK-dependent pathways; therefore, [6]-gingerol may be considered a possible anti-hypersecretory agent.	gingerol	173-181	interleukin 1 beta	Homo sapiens	37-46
19586571-8	2009	Finally, inhibition was slightly higher for IL-1beta, 93.1 % by 3,4-DHPPA and 97.9 % by 3,4-DHPAA.	3,4-dihydroxyphenylpropionic acid	64-73	interleukin 1 beta	Homo sapiens	44-52
19586571-8	2009	Finally, inhibition was slightly higher for IL-1beta, 93.1 % by 3,4-DHPPA and 97.9 % by 3,4-DHPAA.	3,4-Dihydroxyphenylacetic Acid	88-97	interleukin 1 beta	Homo sapiens	44-52
19105226-4	2009	We hypothesized that metal implant debris can activate the inflammasome pathway in macrophages that causes caspase-1-induced cleavage of intracellular pro-IL-1beta into its mature form, resulting in IL-1beta secretion and induction of a broader proinflammatory response.	Metals	21-26	interleukin 1 beta	Homo sapiens	155-163
19590712-4	2009	In this study we investigated the effects of LANSO on the production of TNF-alpha and IL-1beta induced by lipopolysaccharide (LPS) and Helicobacter pylori water-soluble extract (HpWE) in the human monocytic cell line (THP-1).	Water	155-160	interleukin 1 beta	Homo sapiens	86-94
19590712-5	2009	LANSO (100 microM) significantly reduced mRNA expression and production of TNF-alpha and IL-1beta by THP-1 cells stimulated by LPS and HpWE.	Lansoprazole	0-5	interleukin 1 beta	Homo sapiens	89-97
19590712-7	2009	These findings suggest that LANSO exerts anti-inflammatory effects by suppressing induction of TNF-alpha and IL-1beta via inhibition of nuclear factor (NF)-kappaB and ERK activation.	Lansoprazole	28-33	interleukin 1 beta	Homo sapiens	109-117
19590712-4	2009	In this study we investigated the effects of LANSO on the production of TNF-alpha and IL-1beta induced by lipopolysaccharide (LPS) and Helicobacter pylori water-soluble extract (HpWE) in the human monocytic cell line (THP-1).	Lansoprazole	45-50	interleukin 1 beta	Homo sapiens	86-94
19105226-4	2009	We hypothesized that metal implant debris can activate the inflammasome pathway in macrophages that causes caspase-1-induced cleavage of intracellular pro-IL-1beta into its mature form, resulting in IL-1beta secretion and induction of a broader proinflammatory response.	Metals	21-26	interleukin 1 beta	Homo sapiens	199-207
19105226-6	2009	Our results demonstrate that these agents stimulate IL-1beta secretion in human macrophages that is inflammasome mediated (i.e., NADPH-, caspase-1-, Nalp3-, and ASC-dependent).	NADP	129-134	interleukin 1 beta	Homo sapiens	52-60
19444894-13	2009	Ex vivo analysis indicates IL-1beta is responsible for the activation of the COX-2 / PGE2 pathway.	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	27-35
19386793-7	2009	Treatment of human PA-SMCs with roflumilast N-oxide, the active metabolite of roflumilast, at concentrations up to 10(-6) M, potentiated PA-SMC growth inhibition induced by prostacyclin (10(-6) M) or interleukin-1beta (10 ng x ml(-1)) but was inactive on its own.	n-oxide	44-51	interleukin 1 beta	Homo sapiens	200-217
19386793-7	2009	Treatment of human PA-SMCs with roflumilast N-oxide, the active metabolite of roflumilast, at concentrations up to 10(-6) M, potentiated PA-SMC growth inhibition induced by prostacyclin (10(-6) M) or interleukin-1beta (10 ng x ml(-1)) but was inactive on its own.	Epoprostenol	173-185	interleukin 1 beta	Homo sapiens	200-217
19715986-2	2009	The inhibitor of p38 MAP kinase, FR167653, has been proven to be effective to suppress proinflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta in various animal models.	FR 167653	33-41	interleukin 1 beta	Homo sapiens	151-173
19427585-2	2009	We propose that nitric oxide (NO) may represent down stream signaling molecule of IL-1-induced collagen degradation in chondrocytes.	Nitric Oxide	16-28	interleukin 1 beta	Homo sapiens	82-86
20560295-7	2009	The LPS-stimulated IL-1beta production was also suppressed by 10 mM NAC.	Acetylcysteine	68-71	interleukin 1 beta	Homo sapiens	19-27
19483309-4	2009	In the present study, we investigate the effect of Columbianetin on the production of histamine, interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha and expression of cyclooxygenase-2 (COX-2) by using the human mast cell line (HMC-1).	columbianetin	51-64	interleukin 1 beta	Homo sapiens	97-119
19386602-10	2009	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed the IL-1beta-, IFN-gamma- and TNF-alpha-induced IL-32 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interleukin 1 beta	Homo sapiens	86-94
19428335-3	2009	We have investigated whether HO-1 induction may modify chondrocyte viability and the production of relevant mediators such as oxidative stress and prostaglandin E(2) (PGE(2)) elicited by IL-1beta in OA chondrocytes.	Dinoprostone	147-165	interleukin 1 beta	Homo sapiens	187-195
19428335-3	2009	We have investigated whether HO-1 induction may modify chondrocyte viability and the production of relevant mediators such as oxidative stress and prostaglandin E(2) (PGE(2)) elicited by IL-1beta in OA chondrocytes.	Prostaglandins E	167-170	interleukin 1 beta	Homo sapiens	187-195
19428335-8	2009	PGE(2) is produced in OA chondrocytes stimulated by IL-1beta by the coordinated induction of cyclooxygenase-2 and microsomal PGE synthase 1 (mPGES-1).	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	52-60
19503839-9	2009	Therefore, these data identify a novel mechanism of host defense requiring the induction of IL-1beta in synergy with vitamin D activation, for the TLR-induced antimicrobial pathway against an intracellular pathogen.	Vitamin D	117-126	interleukin 1 beta	Homo sapiens	92-100
19357230-0	2009	Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells.	lipoxin A4	0-10	interleukin 1 beta	Homo sapiens	20-28
19357230-7	2009	As shown by quantitative RT-PCR, LXA(4) (10 nM) significantly inhibited (P &lt; 0.05) the IL-1beta-induced stimulation of IL-8 and ICAM-1 expression in these cells.	N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide	33-36	interleukin 1 beta	Homo sapiens	90-98
19357230-8	2009	Furthermore, LXA(4) (10 nM) decreased the expression of IL-1beta-induced IL-8 protein levels (P &lt; 0.05).	lipoxin A4	13-19	interleukin 1 beta	Homo sapiens	56-64
19439823-7	2009	The results suggested that the expression of TNF-alpha and IL-1beta was elevated by polytetrafluoroethylene (PTFE), polylactic-co-glycolic acid (PLGA) and American NPG alloy (p &lt; 0.001).	Polytetrafluoroethylene	84-107	interleukin 1 beta	Homo sapiens	59-67
19439823-7	2009	The results suggested that the expression of TNF-alpha and IL-1beta was elevated by polytetrafluoroethylene (PTFE), polylactic-co-glycolic acid (PLGA) and American NPG alloy (p &lt; 0.001).	Polytetrafluoroethylene	109-113	interleukin 1 beta	Homo sapiens	59-67
19439823-7	2009	The results suggested that the expression of TNF-alpha and IL-1beta was elevated by polytetrafluoroethylene (PTFE), polylactic-co-glycolic acid (PLGA) and American NPG alloy (p &lt; 0.001).	Polylactic Acid-Polyglycolic Acid Copolymer	116-143	interleukin 1 beta	Homo sapiens	59-67
19379726-0	2009	Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Homo sapiens	84-92
19379726-2	2009	The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients.	pyrrolidine dithiocarbamic acid	84-111	interleukin 1 beta	Homo sapiens	148-156
19379726-2	2009	The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients.	pyrrolidine dithiocarbamic acid	113-117	interleukin 1 beta	Homo sapiens	148-156
19379726-6	2009	In contrast, other NF-kappaB inhibitors, such as fenofibrate, N-acetylcysteine and MG132, decreased MMP expression in IL-1beta-stimulated FLSs.	Fenofibrate	49-60	interleukin 1 beta	Homo sapiens	118-126
19379726-6	2009	In contrast, other NF-kappaB inhibitors, such as fenofibrate, N-acetylcysteine and MG132, decreased MMP expression in IL-1beta-stimulated FLSs.	Acetylcysteine	62-78	interleukin 1 beta	Homo sapiens	118-126
19379726-6	2009	In contrast, other NF-kappaB inhibitors, such as fenofibrate, N-acetylcysteine and MG132, decreased MMP expression in IL-1beta-stimulated FLSs.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	83-88	interleukin 1 beta	Homo sapiens	118-126
19483309-6	2009	PMA plus A23187 significantly increased IL-1beta, IL-6, IL-8, and TNF-alpha production compared with media control (p&lt;0.05).	Calcimycin	9-15	interleukin 1 beta	Homo sapiens	40-48
19317852-5	2009	Furthermore, the P2Y(2)R agonist Uridine-5"-triphosphate (UTP) enhanced the release of sAPPalpha in rPCNs treated with IL-1beta or transfected with P2Y(2)R cDNA.	Uridine Triphosphate	33-56	interleukin 1 beta	Homo sapiens	119-127
19115379-6	2009	Inhibition of rho kinase by fasudil, Y27632, or expressing a dominant negative form of rho kinase inhibited the LPC-induced IL-1beta mRNA expression in both astrocytes and HMO6.	fasudil	28-35	interleukin 1 beta	Homo sapiens	124-132
19513610-0	2009	The effects of PDTC on interleukin-1beta-induced nitric oxide production in chondrocytes.	Nitric Oxide	49-61	interleukin 1 beta	Homo sapiens	23-40
19513610-1	2009	In order to find new drugs to inhibit nitric oxide (NO) production, the effects of pyrrolidine dithiocarbamate (PDTC), a nuclear factor-kappa B (NF-kappaB) inhibitor, on recombinant human interleukin-1beta (rhIL-1beta)-induced NO production in chondrocytes were investigated.	pyrrolidine dithiocarbamic acid	83-110	interleukin 1 beta	Homo sapiens	188-205
19317852-5	2009	Furthermore, the P2Y(2)R agonist Uridine-5"-triphosphate (UTP) enhanced the release of sAPPalpha in rPCNs treated with IL-1beta or transfected with P2Y(2)R cDNA.	Uridine Triphosphate	58-61	interleukin 1 beta	Homo sapiens	119-127
19084239-14	2009	At every time point, circulating tumor necrosis factor alph, IL-1beta, and IL-6 were lower in animals receiving PG.	pg	112-114	interleukin 1 beta	Homo sapiens	61-69
19542681-4	2009	An ERK-MAPK pathway inhibitor (U0126), but not a p38 kinase inhibitor (SB203580) or a JNK inhibitor (SP600125), also selectively inhibited IL-1beta-induced MMP-13 production in HAC.	U 0126	31-36	interleukin 1 beta	Homo sapiens	139-147
19414795-10	2009	In conclusion, our results indicate that human macrophages sense trichothecene mycotoxins as a danger signal, which activates caspase-1, and further enables the secretion of IL-1beta and IL-18 from the LPS-primed cells.	trichothecene mycotoxins	65-89	interleukin 1 beta	Homo sapiens	174-182
19344766-2	2009	TNFalpha and Il-1beta stimulate actin filament reorganization in non-neuronal cells often accompanied by the formation of reactive oxygen species (ROS).	Reactive Oxygen Species	122-145	interleukin 1 beta	Homo sapiens	13-21
19344766-2	2009	TNFalpha and Il-1beta stimulate actin filament reorganization in non-neuronal cells often accompanied by the formation of reactive oxygen species (ROS).	Reactive Oxygen Species	147-150	interleukin 1 beta	Homo sapiens	13-21
19344766-4	2009	We demonstrated that, in neuronal cells, TNFalpha and Il-1beta stimulate a transient, redox-dependent reorganization of the actin cytoskeleton into lamellipodia under the regulation of Rac1 and a neuronal NADPH oxidase as the source of ROS.	Reactive Oxygen Species	236-239	interleukin 1 beta	Homo sapiens	54-62
19439372-4	2009	Aluminum adjuvants activate the nucleotide-binding domain and leucine-rich-repeat-containing gene family pyrin-domain-containing 3 (known as NLRP3 or NALP3) inflammasome to activate caspase-1 and to induce proinflammatory cytokines interleukin (IL)-1beta and IL-18 by innate cells.	Aluminum	0-8	interleukin 1 beta	Homo sapiens	232-254
19339971-5	2009	Here we demonstrate that the tyrosine kinase Syk, operating downstream of several immunoreceptor tyrosine-based activation motif (ITAM)-coupled fungal pattern recognition receptors, controls both pro-IL-1beta synthesis and inflammasome activation after cell stimulation with Candida albicans.	Tyrosine	29-37	interleukin 1 beta	Homo sapiens	200-208
19414795-6	2009	As a result, satratoxin-positive S. chartarum activated inflammasome-associated caspase-1, which is needed for proteolytic processing of IL-1beta and IL-18.	satratoxin	13-23	interleukin 1 beta	Homo sapiens	137-145
19414795-7	2009	Furthermore, purified trichothecene mycotoxins, roridin A, verrucarin A, and T-2 toxin activated caspase-1, and these mycotoxins also strongly enhanced LPS-dependent secretion of IL-1beta and IL-18.	trichothecene mycotoxins	22-46	interleukin 1 beta	Homo sapiens	179-187
19414795-7	2009	Furthermore, purified trichothecene mycotoxins, roridin A, verrucarin A, and T-2 toxin activated caspase-1, and these mycotoxins also strongly enhanced LPS-dependent secretion of IL-1beta and IL-18.	roridin A	48-57	interleukin 1 beta	Homo sapiens	179-187
19414795-7	2009	Furthermore, purified trichothecene mycotoxins, roridin A, verrucarin A, and T-2 toxin activated caspase-1, and these mycotoxins also strongly enhanced LPS-dependent secretion of IL-1beta and IL-18.	muconomycin A	59-71	interleukin 1 beta	Homo sapiens	179-187
19281832-5	2009	Moreover, IL-1beta stimulated NF-kappaB and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways, respectively.	calmidazolium	44-47	interleukin 1 beta	Homo sapiens	10-18
19309436-6	2009	Moreover, IL-1beta regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta-evoked catecholamine release and the cytokine induces tyrosine hydroxylase Ser40 phosphorylation.	Catecholamines	29-42	interleukin 1 beta	Homo sapiens	10-18
19281832-5	2009	Moreover, IL-1beta stimulated NF-kappaB and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways, respectively.	ros	113-116	interleukin 1 beta	Homo sapiens	10-18
19223071-7	2009	The in vitro inflammatory assessment showed that the MAPDL coating inhibited the TNF-alpha and IL-1beta release from monocyte cells, indicative of good anti-inflammation property.	mapdl	53-58	interleukin 1 beta	Homo sapiens	95-103
19286391-3	2009	METHODS: Fifty-percent ethanol tinctures were prepared from roots, stems, leaves, and flowers and tested separately for their ability to influence production of IL-1beta, IL-2, IL-10, and TNF-alpha as well as proliferation by young human adult peripheral blood mononuclear cells (PMBC) in vitro.	Ethanol	23-30	interleukin 1 beta	Homo sapiens	161-169
18710704-8	2009	Curcumin (NF-kappaB inhibitor) significantly inhibited all these IL-1 beta-mediated effects.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	65-74
19220658-11	2009	In addition, we found muscovite inhibited the expression of TNF-alpha, IL-1beta secreted by THP-1 and IL-8 secreted by HT-29 cells in a dose-dependent manner.	muscovite	22-31	interleukin 1 beta	Homo sapiens	71-79
19309436-0	2009	Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1beta: role of neuropeptide Y and nitric oxide.	Catecholamines	14-27	interleukin 1 beta	Homo sapiens	98-115
19309436-0	2009	Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1beta: role of neuropeptide Y and nitric oxide.	chromaffin	78-88	interleukin 1 beta	Homo sapiens	98-115
19309436-2	2009	The aim of our work was to study the role of the cytokine interleukin-1beta (IL-1beta) on catecholamine release and synthesis from primary cell cultures of human adrenal chromaffin cells.	Catecholamines	90-103	interleukin 1 beta	Homo sapiens	58-75
19490803-5	2009	IL-1 beta-induced reactive oxygen species (ROS) formation and GRX-1 expression in the airway epithelial cells was determined by flow cytometry and immunoassay.	Reactive Oxygen Species	18-41	interleukin 1 beta	Homo sapiens	0-9
19490803-5	2009	IL-1 beta-induced reactive oxygen species (ROS) formation and GRX-1 expression in the airway epithelial cells was determined by flow cytometry and immunoassay.	Reactive Oxygen Species	43-46	interleukin 1 beta	Homo sapiens	0-9
19490803-8	2009	IL-1 beta increased the intracellular ROS formation and GRX-1 expression in airway epithelial cells.	Reactive Oxygen Species	38-41	interleukin 1 beta	Homo sapiens	0-9
19490803-9	2009	The inhibition of IL-1 beta-induced ROS production by N-acetyl-cystein, an ROS scavenger, reduced GRX-1 expression.	Reactive Oxygen Species	36-39	interleukin 1 beta	Homo sapiens	18-27
19490803-9	2009	The inhibition of IL-1 beta-induced ROS production by N-acetyl-cystein, an ROS scavenger, reduced GRX-1 expression.	n-acetyl-cystein	54-70	interleukin 1 beta	Homo sapiens	18-27
19490803-9	2009	The inhibition of IL-1 beta-induced ROS production by N-acetyl-cystein, an ROS scavenger, reduced GRX-1 expression.	Reactive Oxygen Species	75-78	interleukin 1 beta	Homo sapiens	18-27
19490803-12	2009	IL-1 beta-induced up-regulation of GRX-1 in airway epithelial cells is probably mediated by ROS.	Reactive Oxygen Species	92-95	interleukin 1 beta	Homo sapiens	0-9
19490803-13	2009	Glucocorticoids can regulate IL-1 beta-induced ROS formation and GRX-1 expression.	Reactive Oxygen Species	47-50	interleukin 1 beta	Homo sapiens	29-38
19426689-4	2009	Garcinol suppressed 5-lipoxygenase product formation also in intact human neutrophils and reduced PGE2 formation in interleukin-1beta-stimulated A549 human lung carcinoma cells as well as in human whole blood stimulated by lipopolysaccharide.	garcinol	0-8	interleukin 1 beta	Homo sapiens	116-133
19426689-4	2009	Garcinol suppressed 5-lipoxygenase product formation also in intact human neutrophils and reduced PGE2 formation in interleukin-1beta-stimulated A549 human lung carcinoma cells as well as in human whole blood stimulated by lipopolysaccharide.	Dinoprostone	98-102	interleukin 1 beta	Homo sapiens	116-133
19309436-2	2009	The aim of our work was to study the role of the cytokine interleukin-1beta (IL-1beta) on catecholamine release and synthesis from primary cell cultures of human adrenal chromaffin cells.	Catecholamines	90-103	interleukin 1 beta	Homo sapiens	77-85
19309436-3	2009	The effect of IL-1beta on neuropeptide Y (NPY) release and the intracellular pathways involved in catecholamine release evoked by IL-1beta and NPY were also investigated.	Catecholamines	98-111	interleukin 1 beta	Homo sapiens	130-138
19309436-4	2009	We observed that IL-1beta increases the release of NPY, norepinephrine (NE), and epinephrine (EP) from human chromaffin cells.	Norepinephrine	56-70	interleukin 1 beta	Homo sapiens	17-25
19309436-6	2009	Moreover, IL-1beta regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta-evoked catecholamine release and the cytokine induces tyrosine hydroxylase Ser40 phosphorylation.	Catecholamines	29-42	interleukin 1 beta	Homo sapiens	105-113
19309436-4	2009	We observed that IL-1beta increases the release of NPY, norepinephrine (NE), and epinephrine (EP) from human chromaffin cells.	Epinephrine	59-70	interleukin 1 beta	Homo sapiens	17-25
19309436-6	2009	Moreover, IL-1beta regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta-evoked catecholamine release and the cytokine induces tyrosine hydroxylase Ser40 phosphorylation.	Catecholamines	121-134	interleukin 1 beta	Homo sapiens	10-18
19309436-5	2009	Moreover, the immunoneutralization of released NPY inhibits catecholamine release evoked by IL-1beta.	Catecholamines	60-73	interleukin 1 beta	Homo sapiens	92-100
19309436-6	2009	Moreover, IL-1beta regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta-evoked catecholamine release and the cytokine induces tyrosine hydroxylase Ser40 phosphorylation.	Catecholamines	121-134	interleukin 1 beta	Homo sapiens	105-113
19309436-7	2009	Moreover, IL-1beta induces catecholamine release by a mitogen-activated protein kinase (MAPK)-dependent mechanism, and by nitric oxide synthase activation.	Catecholamines	27-40	interleukin 1 beta	Homo sapiens	10-18
19309436-9	2009	Using human chromaffin cells, our data suggest that IL-1beta, NPY, and nitric oxide (NO) may contribute to a regulatory loop between the immune and the adrenal systems, and this is relevant in pathological conditions such as infection, trauma, stress, or in hypertension.	chromaffin	12-22	interleukin 1 beta	Homo sapiens	52-60
19405830-11	2009	The alcohol-containing mouthwashes tested in this study do not cause significant cytotoxic damage and may slightly stimulate IL-1beta release.	Alcohols	4-11	interleukin 1 beta	Homo sapiens	125-133
19190237-4	2009	We tested the effects of ACh on fibroblast proliferation and its ability to bind fibroblasts from patients with COPD, control smokers, controls, and HFL-1 stimulated with IL-1beta, TNF-alpha, and CSE.	Acetylcholine	25-28	interleukin 1 beta	Homo sapiens	171-179
19190237-8	2009	The binding of ACh was higher in patients with COPD and in control smokers than in controls and in CSE-treated than in IL-1beta- and TNF-alpha-stimulated HFL-1 cells.	Acetylcholine	15-18	interleukin 1 beta	Homo sapiens	119-127
19272778-0	2009	First asymmetric synthesis of CJ-14877 and its enantiomer and their interleukin-1beta inhibitory activities.	methyl 5-(7,8-dihydroxypropyl)pyridine-2-carboxylate	30-38	interleukin 1 beta	Homo sapiens	68-85
19175556-6	2009	Despite similar pulmonary function and histologic markers of injury in both groups and higher IL-1beta in the donor of ACDD, IL-8 during reperfusion was significantly lower in ACDD (119 +/- 33% of basal) than in HBD (306 +/- 238%, P &lt; 0.05) recipients.	acdd	119-123	interleukin 1 beta	Homo sapiens	94-102
19302812-6	2009	KEY FINDINGS: TNF-alpha (from 0.1 to 10 ng/ml) and IL-1beta (from 0.1 to 1 ng/ml) stimulated TNAP activity and mineralization in MSCs.	1,3,5-trinitro-2-acetylpyrrole	93-97	interleukin 1 beta	Homo sapiens	51-59
19201816-9	2009	Moreover, the protective effect of BPS was associated with a reduction of the expression of proinflammatory cytokines including TNFalpha and IL-1beta and a normalized biological oxidant activity.	beraprost	35-38	interleukin 1 beta	Homo sapiens	141-149
21475837-2	2009	Using GeneChip analysis, we found that interleukin (IL)-1beta induces the gene expression of PTGER4, which encodes the PGE2 receptor subtype EP4 (PGE2EP4).	pge2ep4	146-153	interleukin 1 beta	Homo sapiens	39-61
21475837-4	2009	Immunofluorescence microscopy revealed a corresponding upregulation in the production of PGE2EP4 protein in IL-1beta-pretreated MH7A cells.	pge2ep4	89-96	interleukin 1 beta	Homo sapiens	108-116
19918215-5	2009	Thus, study of PRRs has also revealed how previously mysterious immunomodulators are able to mediate their actions, including the vaccine adjuvant aluminum hydroxide that activates a cytosolic protein complex known as the Nacht domain leucine-rich repeat and pyrin domain-containing protein 3 inflammasome leading to interleukin-1beta production.	Aluminum Hydroxide	147-165	interleukin 1 beta	Homo sapiens	317-334
19342688-5	2009	Because IL-1beta is also known to induce reactive oxygen species (ROS) through Ras-mediated activation of NADPH oxidase, we investigated the implication of Ras in ADAMTS-4 regulation.	Reactive Oxygen Species	41-64	interleukin 1 beta	Homo sapiens	8-16
19342688-5	2009	Because IL-1beta is also known to induce reactive oxygen species (ROS) through Ras-mediated activation of NADPH oxidase, we investigated the implication of Ras in ADAMTS-4 regulation.	Reactive Oxygen Species	66-69	interleukin 1 beta	Homo sapiens	8-16
19342688-6	2009	Ras knockdown, or inhibition of ROS by antioxidants along with the ablation of MyD88, IRAK1, or TRAF6 more potently down-regulated IL-1beta-induced ADAMTS-4.	Reactive Oxygen Species	32-35	interleukin 1 beta	Homo sapiens	131-139
19342688-9	2009	These findings suggest that Ras, ROS along with MyD88, IRAK1, or TRAF6 synergistically mediate ADAMTS-4 regulation by IL1-beta.	Reactive Oxygen Species	33-36	interleukin 1 beta	Homo sapiens	118-126
19109223-2	2009	Although the mechanism of FM weakening leading to rupture is not completely understood, proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 beta (IL1B), have been shown to weaken FMs concomitant with the induction of reactive oxygen species, collagen remodeling, and prostaglandin release.	Reactive Oxygen Species	248-271	interleukin 1 beta	Homo sapiens	157-175
19109223-2	2009	Although the mechanism of FM weakening leading to rupture is not completely understood, proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 beta (IL1B), have been shown to weaken FMs concomitant with the induction of reactive oxygen species, collagen remodeling, and prostaglandin release.	Reactive Oxygen Species	248-271	interleukin 1 beta	Homo sapiens	177-181
19109223-2	2009	Although the mechanism of FM weakening leading to rupture is not completely understood, proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 beta (IL1B), have been shown to weaken FMs concomitant with the induction of reactive oxygen species, collagen remodeling, and prostaglandin release.	Prostaglandins	298-311	interleukin 1 beta	Homo sapiens	157-175
19109223-2	2009	Although the mechanism of FM weakening leading to rupture is not completely understood, proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 beta (IL1B), have been shown to weaken FMs concomitant with the induction of reactive oxygen species, collagen remodeling, and prostaglandin release.	Prostaglandins	298-311	interleukin 1 beta	Homo sapiens	177-181
19109223-11	2009	Lipoic acid pretreatment also inhibited TNF- and IL1B-induced increases in MMP9 protein activity and release in amnion epithelial cells, as well as PGE(2) increases in both amnion epithelial and mesenchymal cells.	Thioctic Acid	0-11	interleukin 1 beta	Homo sapiens	49-53
19109223-11	2009	Lipoic acid pretreatment also inhibited TNF- and IL1B-induced increases in MMP9 protein activity and release in amnion epithelial cells, as well as PGE(2) increases in both amnion epithelial and mesenchymal cells.	Prostaglandins E	148-151	interleukin 1 beta	Homo sapiens	49-53
19019580-9	2009	CSF lactate was correlated with CSF concentrations of IL-1beta, IL-6, GM-CSF, G-CSF, IFN-gamma and MIP-1beta.	Lactic Acid	4-11	interleukin 1 beta	Homo sapiens	54-62
19336930-3	2009	Although (+/-)-3-methoxynordomesticine possesses weak antimicrobial activity, it inhibits the production of nitric oxide (NO), prostaglandin (PG)E(2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 and the expression of inducible nitric oxide synthase (iNOS) and cycloxygenase (COX)-2 in macrophages stimulated with LPS in vitro.	(+/-)-3-methoxynordomesticine	9-38	interleukin 1 beta	Homo sapiens	186-209
19249142-0	2009	Possible protective effect of serum beta-carotene levels on the association between interleukin-1B C-31T polymorphism and hypertension in a Japanese population.	beta Carotene	36-49	interleukin 1 beta	Homo sapiens	84-98
19249142-3	2009	We investigated the effect of serum beta-carotene levels on the association between the interleukin-1beta (IL-1B) C-31T polymorphism and hypertension.	beta Carotene	36-49	interleukin 1 beta	Homo sapiens	88-105
19249142-3	2009	We investigated the effect of serum beta-carotene levels on the association between the interleukin-1beta (IL-1B) C-31T polymorphism and hypertension.	beta Carotene	36-49	interleukin 1 beta	Homo sapiens	107-112
19249142-10	2009	CONCLUSION: This study suggests that the IL-1B C-31T polymorphism is associated with hypertension, and that this association is modulated by serum beta-carotene levels.	beta Carotene	147-160	interleukin 1 beta	Homo sapiens	41-46
19333945-10	2009	The expression of miR-146 was markedly elevated by IL-1beta stimulation in human chondrocytes in vitro.	mir-146	18-25	interleukin 1 beta	Homo sapiens	51-59
19058794-8	2009	However, treatment with the neuroleptic risperidone for 4 weeks significantly decreased serum levels and PBMC mRNA expressions of IL-1beta in schizophrenic patients.	Risperidone	40-51	interleukin 1 beta	Homo sapiens	130-138
19558361-5	2009	The results showed that both TMC-SOD and heparin-SOD could significantly lower the levels of transforming growth factor-beta1 (TGF-beta1) and interleukine-1beta (IL-1beta) expressed by irradiated 3T3 fibroblasts.	tmc	29-32	interleukin 1 beta	Homo sapiens	162-170
19222370-8	2009	N-mannan-linked residues, chitin, and beta-glucan from C. albicans are important for IL-1beta stimulation.	n-mannan	0-8	interleukin 1 beta	Homo sapiens	85-93
19222370-8	2009	N-mannan-linked residues, chitin, and beta-glucan from C. albicans are important for IL-1beta stimulation.	Chitin	26-32	interleukin 1 beta	Homo sapiens	85-93
19222370-8	2009	N-mannan-linked residues, chitin, and beta-glucan from C. albicans are important for IL-1beta stimulation.	beta-Glucans	38-49	interleukin 1 beta	Homo sapiens	85-93
19222370-9	2009	Surprisingly, processing and secretion of IL-1beta in monocytes did not require pathogen-mediated inflammasome activation, because of the constitutive activation of caspase-1 and the capability of monocytes to release endogenous adenosine-5"-triphosphate.	Adenosine Triphosphate	229-254	interleukin 1 beta	Homo sapiens	42-50
19181383-7	2009	In contrast, an inhibitor of both IRAK-1 and IRAK-4 (RO0884) reduced IL-1beta induced p38 MAP kinase, c-Jun N-terminal kinase activation, and IL-6 production in HUVEC.	ro0884	53-59	interleukin 1 beta	Homo sapiens	69-77
19181383-8	2009	RO0884 also antagonized IL-1beta, TNFalpha, and TLR-mediated cytokine production in human fibroblast-like synoviocytes and peripheral blood mononuclear cells.	ro0884	0-6	interleukin 1 beta	Homo sapiens	24-32
18926729-9	2009	Ex vivo release of interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha by synovial tissue was decreased by treatment with celecoxib, whereas in the indomethacin group only IL-1 beta release was decreased.	Celecoxib	134-143	interleukin 1 beta	Homo sapiens	19-37
18926729-9	2009	Ex vivo release of interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha by synovial tissue was decreased by treatment with celecoxib, whereas in the indomethacin group only IL-1 beta release was decreased.	Celecoxib	134-143	interleukin 1 beta	Homo sapiens	39-48
19309495-0	2009	Taurolidine reduces the tumor stimulating cytokine interleukin-1beta in patients with resectable gastrointestinal cancer: a multicentre prospective randomized trial.	taurolidine	0-11	interleukin 1 beta	Homo sapiens	51-68
19097143-6	2009	IL-1 beta stimulated PKC alpha translocation to plasma membrane leading to phosphorylation of JNK1/2, which was attenuated by PKC inhibitors and transfection with shRNAs of JNK1/2, but not by helenalin.	helenalin	192-201	interleukin 1 beta	Homo sapiens	0-9
19345795-3	2009	We found that IL-1beta stimulated PGF(2alpha) production of human dental pulp cells.	Prostaglandins F	34-37	interleukin 1 beta	Homo sapiens	14-22
19345795-5	2009	Aspirin inhibited IL-1beta-induced PGF(2alpha), but not IL-8 production.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	18-26
19345795-5	2009	Aspirin inhibited IL-1beta-induced PGF(2alpha), but not IL-8 production.	Prostaglandins F	35-38	interleukin 1 beta	Homo sapiens	18-26
19019013-0	2009	IL1beta- and LPS-induced serotonin secretion is increased in EC cells derived from Crohn"s disease.	Serotonin	25-34	interleukin 1 beta	Homo sapiens	0-7
19019013-9	2009	Interleukins (IL1beta) and bacterial products (E. coli LPS) stimulated 5HT secretion from Crohn"s EC cells via TIL receptor activation (TLR4 and IL1beta).	Serotonin	71-74	interleukin 1 beta	Homo sapiens	14-21
19019013-9	2009	Interleukins (IL1beta) and bacterial products (E. coli LPS) stimulated 5HT secretion from Crohn"s EC cells via TIL receptor activation (TLR4 and IL1beta).	Serotonin	71-74	interleukin 1 beta	Homo sapiens	145-152
19004647-5	2009	We applied human recombinant IL-1beta intra-nasally 1h before seizures induced by moist warm air.	Hydrogen	52-54	interleukin 1 beta	Homo sapiens	29-37
19493498-0	2009	[Role of interleukin-1 beta in deltamethrin neurotoxicity].	decamethrin	31-43	interleukin 1 beta	Homo sapiens	9-27
19135383-4	2009	We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex.	lpil	14-18	interleukin 1 beta	Homo sapiens	156-164
19255448-0	2009	Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1beta in human monocytes and multiple sclerosis.	Glatiramer Acetate	0-18	interleukin 1 beta	Homo sapiens	83-91
19255448-9	2009	Indeed, in LPS-activated monocytes, IL-1beta and sIL-1Ra production were increased in the presence of GA.	Glatiramer Acetate	102-104	interleukin 1 beta	Homo sapiens	36-44
19255448-10	2009	These results demonstrate that, in chronic inflammatory conditions, GA enhances circulating sIL-1Ra levels and directly affects monocytes by triggering a bias toward a less inflammatory profile, increasing sIL-1Ra while diminishing IL-1beta production.	Glatiramer Acetate	68-70	interleukin 1 beta	Homo sapiens	232-240
19220017-4	2009	We describe herein the synthesis and biological activity of a series of imidazoline-based scaffolds as potent inhibitors of NF-kappaB mediated gene transcription in cell culture as well as inhibitors of TNF-alpha and IL-6 production in interleukin 1 beta (IL-1beta) stimulated human blood.	Imidazolines	72-83	interleukin 1 beta	Homo sapiens	236-254
19220017-4	2009	We describe herein the synthesis and biological activity of a series of imidazoline-based scaffolds as potent inhibitors of NF-kappaB mediated gene transcription in cell culture as well as inhibitors of TNF-alpha and IL-6 production in interleukin 1 beta (IL-1beta) stimulated human blood.	Imidazolines	72-83	interleukin 1 beta	Homo sapiens	256-264
19104081-3	2009	Here we demonstrate that human blood monocytes release processed IL-1beta after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from constitutively activated caspase-1 and release of endogenous adenosine triphosphate.	Adenosine Triphosphate	213-235	interleukin 1 beta	Homo sapiens	65-73
19135383-4	2009	We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex.	lpil	14-18	interleukin 1 beta	Homo sapiens	85-93
19273625-5	2009	Furthermore, PGE2 synergizes with IL-1beta and IL-23 to drive retinoic acid receptor-related orphan receptor (ROR)-gammat, IL-17, IL-17F, CCL20, and CCR6 expression, which is consistent with the reported Th17 phenotype.	Dinoprostone	13-17	interleukin 1 beta	Homo sapiens	34-42
19135383-4	2009	We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex.	Dexamethasone	71-74	interleukin 1 beta	Homo sapiens	85-93
19085934-9	2009	Exogenous L-DOPA inhibited lymphocyte proliferation producing the cell cycle arrest in G1/0 and dramatically inhibited the production of IL-1beta, TNF-alpha, IL-6 and IL-10.	Levodopa	10-16	interleukin 1 beta	Homo sapiens	137-145
19135383-4	2009	We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex.	lpil	205-209	interleukin 1 beta	Homo sapiens	85-93
19135383-4	2009	We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex.	lpil	205-209	interleukin 1 beta	Homo sapiens	156-164
19135383-4	2009	We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex.	Dexamethasone	235-238	interleukin 1 beta	Homo sapiens	85-93
19135383-5	2009	We also found that IL-1beta-induced release of IL-8 from MH7A cells was completely blocked by pretreatment with the (IL-8) inhibitor Bay11-7085, indicating that activation of NF-kappaB signaling plays an important role in the secretion of IL-8.	BAY 11-7085	133-143	interleukin 1 beta	Homo sapiens	19-27
19473564-10	2009	Furthermore, tacrolimus also decreased the IL-1Beta-induced DNA binding activity of p65, a subunit of NF-KappaB, in the presence of 10-9 M of Dex.	Tacrolimus	13-23	interleukin 1 beta	Homo sapiens	43-51
19248106-11	2009	CS enhanced the IL-1beta-induced level of HAS2 mRNA and reduced the level of HAS3 mRNA.	Chondroitin Sulfates	0-2	interleukin 1 beta	Homo sapiens	16-24
19248106-12	2009	IL-1beta-induced activation of p38 and JNK was slightly decreased by CS, whereas that of ERK-1/2 and Akt was enhanced.	Chondroitin Sulfates	69-71	interleukin 1 beta	Homo sapiens	0-8
18785879-4	2009	Human CASMCs (coronary artery smooth muscle cells) in culture exposed to IL (interleukin)-1beta or TNF-alpha (tumour necrosis factor-alpha) had increased superoxide generation and enhanced CD40 expression, detected by EPR (electron paramagnetic resonance) and immunoblotting respectively.	Superoxides	154-164	interleukin 1 beta	Homo sapiens	73-95
19112099-9	2009	The mRNA levels of the proinflammatory cytokines interleukin (IL)-1beta and IL-8 were also lower (P &lt; 0.05) in ethanol-exposed fetuses compared with controls.	Ethanol	114-121	interleukin 1 beta	Homo sapiens	49-71
19473564-10	2009	Furthermore, tacrolimus also decreased the IL-1Beta-induced DNA binding activity of p65, a subunit of NF-KappaB, in the presence of 10-9 M of Dex.	Dexamethasone	142-145	interleukin 1 beta	Homo sapiens	43-51
19142568-2	2009	AIM OF THE STUDY: We investigated the effects of carnosic acid on the adhesion of U937 cells to IL-1beta-treated human umbilical vein endothelial cells (HUVECs), as well as on the expression of adhesion molecules.	salvin	49-62	interleukin 1 beta	Homo sapiens	96-104
19142568-3	2009	RESULTS: Our data showed that pretreatment with 10 and 20 micromol/l carnosic acid significantly reduced the number of U937 cells adhering to IL-1beta-treated HUVECs.	salvin	69-82	interleukin 1 beta	Homo sapiens	142-150
19142568-4	2009	In addition, we found that 20 micromol/l carnosic was more effective than 10 micromol/l carnosic acid at inhibiting expression of cell adhesion molecules (ICAM-1, VCAM-1, and E-selectin), the nuclear translocation of NF-kappaB subunits p65 and p50, and the production of ROS in IL-1beta-stimulated HUVECs.	carnosic	41-49	interleukin 1 beta	Homo sapiens	278-286
19234194-5	2009	By measuring the cytokine secretion (RANTES/CCL5 and IL-1beta) as an exocytotic model, we show that hSCAMP5 can promote the calcium-regulated signal peptide-containing cytokine (CCL5 but not IL-1beta) secretion in human epithelial cancer cells, human monocytes, and mouse macrophages.	Calcium	124-131	interleukin 1 beta	Homo sapiens	53-61
19142568-5	2009	CONCLUSIONS: We conclude that carnosic acid inhibits IL-1beta-induced ICAM-1, VCAM-1 and E-selectin expression in HUVECs through a mechanism that involves NFkappaB.	salvin	30-43	interleukin 1 beta	Homo sapiens	53-61
19234194-5	2009	By measuring the cytokine secretion (RANTES/CCL5 and IL-1beta) as an exocytotic model, we show that hSCAMP5 can promote the calcium-regulated signal peptide-containing cytokine (CCL5 but not IL-1beta) secretion in human epithelial cancer cells, human monocytes, and mouse macrophages.	Calcium	124-131	interleukin 1 beta	Homo sapiens	191-199
19142568-6	2009	We propose that the reduction in binding of human monocytic cell line U937 to IL-1beta-treated HUVECs is due to the anti-inflammatory properties of carnosic acid.	salvin	148-161	interleukin 1 beta	Homo sapiens	78-86
18685861-5	2009	Systolic blood pressure was markedly increased and circulating levels of IL-1beta, IL-1Ra, and IL-8 were significantly reduced during a 2-h interval of PMX.	(+)-xylariamide A	152-155	interleukin 1 beta	Homo sapiens	73-81
19304545-1	2009	OBJECTIVE: To investigate the role of sodium cromoglycate in brain protection and its effects on brain tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) expressions after global cerebral ischemia-reperfusion (IR) injury in gerbils.	Cromolyn Sodium	38-57	interleukin 1 beta	Homo sapiens	147-164
19052845-7	2009	The IL-1 beta inducible ADAMTS9 expression was inhibited by NFAT inhibitors, FK506 and 11Arg (11R)-VIVIT.	Tacrolimus	77-82	interleukin 1 beta	Homo sapiens	4-13
19304545-1	2009	OBJECTIVE: To investigate the role of sodium cromoglycate in brain protection and its effects on brain tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) expressions after global cerebral ischemia-reperfusion (IR) injury in gerbils.	Cromolyn Sodium	38-57	interleukin 1 beta	Homo sapiens	166-174
19304545-8	2009	The brain TNF-alpha and IL-1beta levels in sodium cromoglycate group were significantly decreased as compared with those in the model group (P&lt;0.05).	Cromolyn Sodium	43-62	interleukin 1 beta	Homo sapiens	24-32
19304545-9	2009	CONCLUSION: Sodium cromoglycate can alleviate brain IR injury possibly by lowering the TNF-alpha and IL-1beta levels in the brain tissues.	Cromolyn Sodium	12-31	interleukin 1 beta	Homo sapiens	101-109
19135800-4	2009	The PGI also induced a prominent increase in IL-1beta and TNF-alpha levels in the DRG and of cyclooxygenase-2 (COX-2) expression in neurons and satellite cells.	2cer	4-7	interleukin 1 beta	Homo sapiens	45-53
19135800-6	2009	We also show that IL-1beta induces COX-2 expression and prostaglandin release in DRG neurons in vitro in a MAP kinase-dependent fashion.	Prostaglandins	56-69	interleukin 1 beta	Homo sapiens	18-26
19135800-8	2009	We conclude that periganglionic inflammation increases cytokine levels, including IL-1beta, leading to the transcription of COX-2 and prostaglandin production in the affected DRG, and thereby to the development of a dermatomally distributed pain hypersensitivity.	Prostaglandins	134-147	interleukin 1 beta	Homo sapiens	82-90
18568426-1	2009	ATP, acting on P2X(7) receptors, stimulates changes in intracellular calcium concentrations, maturation, and release of interleukin-1beta (IL-1beta), and following prolonged agonist exposure, cell death.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	120-137
19443940-2	2009	Previous studies have revealed that therapy with leflunomide causes decreased production of mediators such as IL-1beta, IL-6, and TNF-alpha, which are involved in inflammatory process.	Leflunomide	49-60	interleukin 1 beta	Homo sapiens	110-118
19443940-3	2009	The aim of the present study was to examine whether the polymorphisms in genes IL1B, IL6, and TNF may affect treatment outcomes in RA patients treated with leflunomide.	Leflunomide	156-167	interleukin 1 beta	Homo sapiens	79-83
18568426-1	2009	ATP, acting on P2X(7) receptors, stimulates changes in intracellular calcium concentrations, maturation, and release of interleukin-1beta (IL-1beta), and following prolonged agonist exposure, cell death.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	139-147
19278584-13	2009	The IKK-2 inhibitor, SC-514, inhibited IL-1beta induced IKappaBalpha protein activity, blocked p65 nuclear translocation, caused a significant reduction in IL-1beta induced DNA binding activity for p65 and ICAM-1 mRNA expression, and suppressed ICAM-1 expression on A549 cell surface (all P&lt;0.01).	SC 514	21-27	interleukin 1 beta	Homo sapiens	39-47
19304545-0	2009	[Role of sodium cromoglycate in brain protection and its effects on tumor necrosis factor-alpha and interleukin-1beta after global cerebral ischemia-reperfusion injury in gerbils].	Cromolyn Sodium	9-28	interleukin 1 beta	Homo sapiens	100-117
19278584-13	2009	The IKK-2 inhibitor, SC-514, inhibited IL-1beta induced IKappaBalpha protein activity, blocked p65 nuclear translocation, caused a significant reduction in IL-1beta induced DNA binding activity for p65 and ICAM-1 mRNA expression, and suppressed ICAM-1 expression on A549 cell surface (all P&lt;0.01).	SC 514	21-27	interleukin 1 beta	Homo sapiens	156-164
19100307-3	2009	We used microarray analysis to examine MTX-induced gene expression in a human lung epithelial cell line (BEAS-2B) and identified 10 differentially expressed genes related to the p38 mitogen-activated protein kinase (MAPK) pathway, including IL-1beta, MKK6, and MAPKAPK2.	Methotrexate	39-42	interleukin 1 beta	Homo sapiens	241-249
19100307-7	2009	MTX activated IL-1beta expression and induced the phosphorylation of various proteins in the p38 MAPK cascade, including TAK1, MKK3/MKK6, p38 MAPK, MAPKAPK2, and HSP27.	Methotrexate	0-3	interleukin 1 beta	Homo sapiens	14-22
19047340-3	2009	However, ROS also stimulate signal transduction to elaborate inflammatory cytokines, e.g. tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and -6, in the ischaemic region and surrounding myocardium as a host reaction.	Reactive Oxygen Species	9-12	interleukin 1 beta	Homo sapiens	132-161
19162335-0	2009	The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid therapy.	Steroids	162-169	interleukin 1 beta	Homo sapiens	16-25
19110420-2	2009	To assess their structure-activity relationships, these compounds were modified at their R(1) and R(2) groups and assayed for their ability to inhibit the 2"(3")-O-(4-benzoylbenzoyl)-ATP (BzATP)-induced uptake of fluorescent ethidium by HEK-293 cells stably expressing the human P2X(7) receptor, and their ability to inhibit BzATP-induced IL-1beta release by differentiated THP-1 cells.	2"(3")-o-(4-benzoylbenzoyl)-atp	155-186	interleukin 1 beta	Homo sapiens	339-347
18390571-0	2009	Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process.	Uric Acid	12-40	interleukin 1 beta	Homo sapiens	87-105
18390571-8	2009	Urate crystals amplified IL1 beta production stimulated by the TLR4 ligand LPS, while no synergy was apparent for IL6 production.	Uric Acid	0-5	interleukin 1 beta	Homo sapiens	25-33
18390571-10	2009	The synergy between urate crystals and LPS was directed at the level of the NALP3 inflammasome, as it was present only when active IL1 beta was measured, but not at the level of IL1 mRNA or proIL1 beta.	Uric Acid	20-25	interleukin 1 beta	Homo sapiens	131-139
18390571-10	2009	The synergy between urate crystals and LPS was directed at the level of the NALP3 inflammasome, as it was present only when active IL1 beta was measured, but not at the level of IL1 mRNA or proIL1 beta.	Uric Acid	20-25	interleukin 1 beta	Homo sapiens	131-134
18586252-4	2009	Results showed that high glucose and IFN gamma had a synergistic effect on the expression of MMP-1, MMP-9 and IL-1 beta.	Glucose	25-32	interleukin 1 beta	Homo sapiens	110-119
18599066-3	2009	Palmitate induced secretion and mRNA expression of TNF-alpha, IL-8 and IL-1 beta, and enhanced lipopolysaccharide (LPS)-induced IL-1 beta secretion.	Palmitates	0-9	interleukin 1 beta	Homo sapiens	71-80
18599066-3	2009	Palmitate induced secretion and mRNA expression of TNF-alpha, IL-8 and IL-1 beta, and enhanced lipopolysaccharide (LPS)-induced IL-1 beta secretion.	Palmitates	0-9	interleukin 1 beta	Homo sapiens	128-137
18629644-10	2009	Trichostatin A, a histone-deacetylase inhibitor, reduced IL-1 beta-induced MMP-1 and MMP-3 mRNA expression, and suppressed TNF-alpha-induced MMP-3 mRNA expression.	trichostatin A	0-14	interleukin 1 beta	Homo sapiens	57-66
19054597-6	2009	RESULTS: 120 microM pure EPA and EPA-rich media significantly (p&lt;0.05) suppressed TNF-alpha and IL-1beta mRNA expression and the production of LTB(4), PGD(2) and TNF-alpha and IL-1beta in LPS-stimulated primary AMphi cells obtained from asthmatic patients to a much greater extent than 120 microM pure DHA and DHA-rich media respectively.	Eicosapentaenoic Acid	25-28	interleukin 1 beta	Homo sapiens	99-107
19054597-6	2009	RESULTS: 120 microM pure EPA and EPA-rich media significantly (p&lt;0.05) suppressed TNF-alpha and IL-1beta mRNA expression and the production of LTB(4), PGD(2) and TNF-alpha and IL-1beta in LPS-stimulated primary AMphi cells obtained from asthmatic patients to a much greater extent than 120 microM pure DHA and DHA-rich media respectively.	Eicosapentaenoic Acid	25-28	interleukin 1 beta	Homo sapiens	179-187
19054597-6	2009	RESULTS: 120 microM pure EPA and EPA-rich media significantly (p&lt;0.05) suppressed TNF-alpha and IL-1beta mRNA expression and the production of LTB(4), PGD(2) and TNF-alpha and IL-1beta in LPS-stimulated primary AMphi cells obtained from asthmatic patients to a much greater extent than 120 microM pure DHA and DHA-rich media respectively.	Eicosapentaenoic Acid	33-36	interleukin 1 beta	Homo sapiens	99-107
19054597-6	2009	RESULTS: 120 microM pure EPA and EPA-rich media significantly (p&lt;0.05) suppressed TNF-alpha and IL-1beta mRNA expression and the production of LTB(4), PGD(2) and TNF-alpha and IL-1beta in LPS-stimulated primary AMphi cells obtained from asthmatic patients to a much greater extent than 120 microM pure DHA and DHA-rich media respectively.	Eicosapentaenoic Acid	33-36	interleukin 1 beta	Homo sapiens	179-187
18629644-7	2009	Propionate and butyrate significantly attenuated IL-1 beta- and TNF-alpha-induced MMP-1 and MMP-3 secretion.	Butyrates	15-23	interleukin 1 beta	Homo sapiens	49-58
19016700-8	2009	CONCLUSIONS: The IL-1beta- and alpha-MSH-related tripeptide, K(D)PT, displays interesting hair pigmentation-stimulatory activities under proinflammatory conditions.	tripeptide K-26	49-59	interleukin 1 beta	Homo sapiens	17-25
19138532-3	2009	The results revealed that DEX nonspecifically and dose-dependently inhibited the production of 12 cytokines (IL-2, IFN-gamma, TNF-alpha, IL-8, IL-1beta, IL-17, IL-4, IL-5, IL-6, IL-10, IL-13, and G-CSF).	Dexamethasone	26-29	interleukin 1 beta	Homo sapiens	143-151
18629644-7	2009	Propionate and butyrate significantly attenuated IL-1 beta- and TNF-alpha-induced MMP-1 and MMP-3 secretion.	Propionates	0-10	interleukin 1 beta	Homo sapiens	49-58
19046877-6	2009	Both the strong TF activity and antigen constitutively expressed by MDA-MB-231 and the TF induced by LPS, TNF-alpha and IL-1beta in MN cells and HUVEC were significantly reduced by paclitaxel.	Paclitaxel	181-191	interleukin 1 beta	Homo sapiens	120-128
19046877-8	2009	Since paclitaxel has been shown to induce the expression of inflammatory genes in monocytes and tumour cells, we tested whether paclitaxel could influence IL-6 and IL-1beta release from the cells used in this paper.	Paclitaxel	128-138	interleukin 1 beta	Homo sapiens	164-172
18776171-3	2009	RSV blocked 10,12 CLA induction of the inflammatory response by preventing activation of extracellular signal-related kinase and induction of inflammatory gene expression (i.e., IL-6, IL-8, IL-1beta) within 12 h. Similarly, RSV suppressed 10,12 CLA-mediated activation of the inflammatory prostaglandin pathway involving phospholipase A(2), cyclooxygenase-2, and PGF(2alpha).	Resveratrol	0-3	interleukin 1 beta	Homo sapiens	190-198
19130485-5	2009	One of the endogenous mediators of IL-1beta secretion is adenosine triphosphate, acting via the P2X7-receptor and caspase-1 activation in cells primed with an inflammatory stimulus such as LPS.	Adenosine Triphosphate	57-79	interleukin 1 beta	Homo sapiens	35-43
19130485-8	2009	TPEN did however inhibit the activity of pannexin-1, a hemi-channel critical for adenosine triphosphate and nigericin-induced IL-1beta release.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	0-4	interleukin 1 beta	Homo sapiens	126-134
19130485-8	2009	TPEN did however inhibit the activity of pannexin-1, a hemi-channel critical for adenosine triphosphate and nigericin-induced IL-1beta release.	Nigericin	108-117	interleukin 1 beta	Homo sapiens	126-134
19100343-8	2009	KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture.	KHBJ-9B	0-7	interleukin 1 beta	Homo sapiens	79-87
19100343-8	2009	KHBJ-9B and the combination of 3 triterpenoids markedly inhibited the level of IL-1beta and TNF-alpha, and down-regulated the level of aggrecanases, ADAMTS-4, ADAMTS-5, MMP-1 and MMP-13, and up-regulated TIMP-3 in human cartilage explants culture.	triterpenoids	33-46	interleukin 1 beta	Homo sapiens	79-87
18838483-2	2009	Selective inhibitors of either COX-1 (SC560 and FR122047) or COX-2 (SC236) concentration dependently (1-300 nM) reduced basal and interleukin (IL) -1beta-induced prostacyclin production in human umbilical vein endothelial cells by 70% or more; compound selectivity was confirmed using a whole-blood assay (IC(50) COX-1/COX-2: 13 nM/930 nM for SC-560; 9 microM/457 nM for SC-236).	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	68-73	interleukin 1 beta	Homo sapiens	130-153
18838483-2	2009	Selective inhibitors of either COX-1 (SC560 and FR122047) or COX-2 (SC236) concentration dependently (1-300 nM) reduced basal and interleukin (IL) -1beta-induced prostacyclin production in human umbilical vein endothelial cells by 70% or more; compound selectivity was confirmed using a whole-blood assay (IC(50) COX-1/COX-2: 13 nM/930 nM for SC-560; 9 microM/457 nM for SC-236).	Epoprostenol	162-174	interleukin 1 beta	Homo sapiens	130-153
19011889-1	2009	BACKGROUND: The purpose of this study was to investigate the effect of clonidine, an alpha(2)-adrenergic receptor (alpha(2)-ADR) agonist, on vascular endothelial growth factor (VEGF) expression and secretion in the human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin-1beta (IL-1beta).	Clonidine	71-80	interleukin 1 beta	Homo sapiens	284-301
19011889-1	2009	BACKGROUND: The purpose of this study was to investigate the effect of clonidine, an alpha(2)-adrenergic receptor (alpha(2)-ADR) agonist, on vascular endothelial growth factor (VEGF) expression and secretion in the human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin-1beta (IL-1beta).	Clonidine	71-80	interleukin 1 beta	Homo sapiens	303-311
19011889-7	2009	Clonidine, an inhibitor of p38MAPK and MEK1/2, inhibited the expression of VEGF protein and mRNA in the RPE cells stimulated with IL-1beta.	Clonidine	0-9	interleukin 1 beta	Homo sapiens	130-138
19011889-8	2009	The inhibitory effect of clonidine on the secretion of VEGF protein stimulated with IL-1beta was blocked by alpha(2)-ADR antagonists.	Clonidine	25-34	interleukin 1 beta	Homo sapiens	84-92
19011889-9	2009	CONCLUSIONS: The effect of clonidine on the expression of VEGF may be via suppression of the p38MAPK and MEK1/2 signal transduction pathways activated with IL-1beta.	Clonidine	27-36	interleukin 1 beta	Homo sapiens	156-164
19171646-7	2009	RESULTS: IL-1beta induced the disappearance of ZO-1 and occludin from the interfaces of neighboring HCE cells without affecting the localization of E-cadherin or beta-catenin.	hce	100-103	interleukin 1 beta	Homo sapiens	9-17
19171646-11	2009	The NF-kappaB inhibitor curcumin blocked the effects of IL-1beta on both TER and the subcellular localization of ZO-1 and occludin.	Curcumin	24-32	interleukin 1 beta	Homo sapiens	56-64
19015376-5	2009	The rapid and strong release of reactive oxygen species and preformed intragranular mediators (myeloperoxidase and IL-8) is followed by a later TNF-alpha, IL-1beta, and IL-8 synthesis.	Reactive Oxygen Species	32-55	interleukin 1 beta	Homo sapiens	155-163
18973517-8	2009	Interleukin-1beta production was significantly lower in smokers compared with non-smokers after stimulation with either LOS or Pg-SE (P &lt; 0.05).	pg-se	127-132	interleukin 1 beta	Homo sapiens	0-17
19452719-0	2009	[Effect of hypoxia and IL-1beta on COX-2 expression and PGE2 release in human nasal epithelia].	Dinoprostone	56-60	interleukin 1 beta	Homo sapiens	23-31
19452719-6	2009	COX-2 expression and PGE2 release increased in HNE induced by hypoxia and/or IL-1beta in time-dependent manner.	Dinoprostone	21-25	interleukin 1 beta	Homo sapiens	77-85
19452719-7	2009	Stronger expressions of COX-2 and PGE2 induced by hypoxia and/or IL-1beta than control were detected on different time (P &lt; 0.05).	Dinoprostone	34-38	interleukin 1 beta	Homo sapiens	65-73
18950863-4	2009	The results showed that the specific inhibitor geldanamycin (GA) of Hsp90 dramatically inhibited IL-1beta stimulated TAK1-MAPKs and TAK1-nuclear factor-kappaB (NF-kappaB) activation, resulting in the decrease of cyclooxygenase-2 (COX-2) protein expression.	geldanamycin	47-59	interleukin 1 beta	Homo sapiens	97-105
18950863-4	2009	The results showed that the specific inhibitor geldanamycin (GA) of Hsp90 dramatically inhibited IL-1beta stimulated TAK1-MAPKs and TAK1-nuclear factor-kappaB (NF-kappaB) activation, resulting in the decrease of cyclooxygenase-2 (COX-2) protein expression.	geldanamycin	61-63	interleukin 1 beta	Homo sapiens	97-105
19452719-9	2009	The expressions of COX-2 and PGE2 in hypoxia+IL-1beta group were more than the sum of hypoxia group and IL-1beta group on same time.	Dinoprostone	29-33	interleukin 1 beta	Homo sapiens	45-53
19452719-9	2009	The expressions of COX-2 and PGE2 in hypoxia+IL-1beta group were more than the sum of hypoxia group and IL-1beta group on same time.	Dinoprostone	29-33	interleukin 1 beta	Homo sapiens	104-112
19452719-10	2009	CONCLUSION: Hypoxia and/or IL-1beta effectively induce COX-2 expression and PGE2 release in HNE.	Dinoprostone	76-80	interleukin 1 beta	Homo sapiens	27-35
19452719-11	2009	Synergistic effect between hypoxia and IL-1beta has been found in induction of COX-2 and PGE2 in HNE.	Dinoprostone	89-93	interleukin 1 beta	Homo sapiens	39-47
19452719-12	2009	Results indicate that the increased expressions of COX-2 and PGE2 are involved in inflammation of HNE induced by hypoxia and/or IL-1beta in vitro.	Dinoprostone	61-65	interleukin 1 beta	Homo sapiens	128-136
19236776-9	2009	The treatment with tanshinone IIa could significantly decrease the serum levels of IL-1beta, TNF-alpha and platelet number, and the efficacy of tanshinone IIa was same as aspirin.	tanshinone	19-33	interleukin 1 beta	Homo sapiens	83-91
19139407-2	2009	Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) (PLG) and polystyrene microparticles, dramatically enhance secretion of interleukin-1beta (IL-1beta) by dendritic cells (DCs).	Polyglactin 910	66-92	interleukin 1 beta	Homo sapiens	165-182
19027837-5	2009	The expression of interleukin (IL)-1beta was significantly induced by DON (except for 12h) and LPS.	deoxynivalenol	70-73	interleukin 1 beta	Homo sapiens	18-40
19027837-5	2009	The expression of interleukin (IL)-1beta was significantly induced by DON (except for 12h) and LPS.	12-hydroxydodecanoic acid	86-89	interleukin 1 beta	Homo sapiens	18-40
19027837-8	2009	The results of the present investigation suggest a contribution of cytokines, especially TNF-alpha and IL-1beta, induced by DON in porcine macrophages to the effects observed in vivo.	deoxynivalenol	124-127	interleukin 1 beta	Homo sapiens	103-111
19139407-2	2009	Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) (PLG) and polystyrene microparticles, dramatically enhance secretion of interleukin-1beta (IL-1beta) by dendritic cells (DCs).	Polyglactin 910	66-92	interleukin 1 beta	Homo sapiens	184-192
19139407-2	2009	Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) (PLG) and polystyrene microparticles, dramatically enhance secretion of interleukin-1beta (IL-1beta) by dendritic cells (DCs).	Polystyrenes	103-114	interleukin 1 beta	Homo sapiens	165-182
19139407-2	2009	Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) (PLG) and polystyrene microparticles, dramatically enhance secretion of interleukin-1beta (IL-1beta) by dendritic cells (DCs).	Polystyrenes	103-114	interleukin 1 beta	Homo sapiens	184-192
19124762-3	2009	Priming of the cells with ER stress inducers (tunicamycin, thapsigargin, A23187, and AB5 subtilase cytotoxin) caused blunted induction of MCP-1 in response to TNF-alpha, IL-1beta, macrophage-derived factors, or bystander macrophages.	Tunicamycin	46-57	interleukin 1 beta	Homo sapiens	170-178
19124762-3	2009	Priming of the cells with ER stress inducers (tunicamycin, thapsigargin, A23187, and AB5 subtilase cytotoxin) caused blunted induction of MCP-1 in response to TNF-alpha, IL-1beta, macrophage-derived factors, or bystander macrophages.	Thapsigargin	59-71	interleukin 1 beta	Homo sapiens	170-178
19124762-3	2009	Priming of the cells with ER stress inducers (tunicamycin, thapsigargin, A23187, and AB5 subtilase cytotoxin) caused blunted induction of MCP-1 in response to TNF-alpha, IL-1beta, macrophage-derived factors, or bystander macrophages.	Calcimycin	73-79	interleukin 1 beta	Homo sapiens	170-178
19081643-2	2009	Administration of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) or the nitric oxide (NO) donor diethylamino-diazenolate-2-oxide (DEA) caused fast transient rises in intracellular calcium concentrations ([Ca(2+)]i) in distinct populations of cells investigated in a primary microculture of the rat AP.	Calcium	203-210	interleukin 1 beta	Homo sapiens	59-76
19081643-2	2009	Administration of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) or the nitric oxide (NO) donor diethylamino-diazenolate-2-oxide (DEA) caused fast transient rises in intracellular calcium concentrations ([Ca(2+)]i) in distinct populations of cells investigated in a primary microculture of the rat AP.	Calcium	203-210	interleukin 1 beta	Homo sapiens	78-86
19302047-3	2009	Thus, fundamental inflammatory responses such as the induction of cyclooxygenase type 2, increased expression of adhesion molecules, or synthesis of nitric oxide are indistinguishable responses of both IL-1 and TLR ligands.	Nitric Oxide	149-161	interleukin 1 beta	Homo sapiens	202-206
19753331-9	2009	On the other hand, a strong enhancement of the expression of both receptors by interleukin 1beta, especially in the phorbol ester-differentiated cells, indicates the involvement of kinin receptors in the propagation of the inflammatory processes.	Phorbol Esters	116-129	interleukin 1 beta	Homo sapiens	79-96
19296842-7	2009	13(S)-hydroxy octadecadienoic and 15(S)-hydroxyeicosatetraenoic acids dose dependently decreased IL-1beta-induced MMP-1 and MMP-13 protein and mRNA expression as well as type II collagen cleavage.	13(s)-hydroxy octadecadienoic	0-29	interleukin 1 beta	Homo sapiens	97-105
19296842-7	2009	13(S)-hydroxy octadecadienoic and 15(S)-hydroxyeicosatetraenoic acids dose dependently decreased IL-1beta-induced MMP-1 and MMP-13 protein and mRNA expression as well as type II collagen cleavage.	15-hydroxy-5,8,11,13-eicosatetraenoic acid	34-69	interleukin 1 beta	Homo sapiens	97-105
19490621-8	2009	RESULTS: Basal and IL-1beta-induced 2-DG uptake, including the affinity (1.066 +/- 0.284 and 1.49 +/- 0.59 mM) and maximal velocity (0.27 +/- 0.08 and 0.33 +/- 0.08 nmol/microg protein/hour), and GLUT-1 content were identical in normal and OA chondrocytes.	Deoxyglucose	36-40	interleukin 1 beta	Homo sapiens	19-27
19435506-1	2009	INTRODUCTION: The aim of this study was to compare the effects of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1beta) on protease and catabolic cytokine and receptor gene expression in normal and degenerate human nucleus pulposus cells in alginate culture.	Alginates	262-270	interleukin 1 beta	Homo sapiens	111-129
19296842-11	2009	Their respective metabolites, namely 13(S)-hydroxy octadecadienoic and 15(S)-hydroxyeicosatetraenoic acids, suppressed IL-1beta-induced MMP-1 and MMP-13 expression in a PPARgamma-dependent pathway.	13(s)-hydroxy octadecadienoic	37-66	interleukin 1 beta	Homo sapiens	119-127
19435506-1	2009	INTRODUCTION: The aim of this study was to compare the effects of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1beta) on protease and catabolic cytokine and receptor gene expression in normal and degenerate human nucleus pulposus cells in alginate culture.	Alginates	262-270	interleukin 1 beta	Homo sapiens	131-139
19296842-11	2009	Their respective metabolites, namely 13(S)-hydroxy octadecadienoic and 15(S)-hydroxyeicosatetraenoic acids, suppressed IL-1beta-induced MMP-1 and MMP-13 expression in a PPARgamma-dependent pathway.	15-hydroxy-5,8,11,13-eicosatetraenoic acid	71-106	interleukin 1 beta	Homo sapiens	119-127
19327174-0	2009	Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models.	piperine	47-55	interleukin 1 beta	Homo sapiens	65-82
19327174-2	2009	METHODS: The in vitro anti-inflammatory activity of piperine was tested on interleukin 1beta (IL1beta)-stimulated fibroblast-like synoviocytes derived form patients with rheumatoid arthritis.	piperine	52-60	interleukin 1 beta	Homo sapiens	75-92
19327174-2	2009	METHODS: The in vitro anti-inflammatory activity of piperine was tested on interleukin 1beta (IL1beta)-stimulated fibroblast-like synoviocytes derived form patients with rheumatoid arthritis.	piperine	52-60	interleukin 1 beta	Homo sapiens	94-101
19889203-9	2009	IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.	Curcumin	78-86	interleukin 1 beta	Homo sapiens	0-8
19889203-0	2009	Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis.	Curcumin	41-49	interleukin 1 beta	Homo sapiens	113-121
18495130-7	2009	Pretreatment of human monocytes with candesartan significantly decreased Pam3CSK4 or LPS induced TLR2 and TLR4 expression of both mRNA and protein levels (P&lt;0.05 vs. control) along with decrease in the activity of NF-kappaB and the expression of IL-1beta, IL-6, TNF-alpha, and MCP-1.	candesartan	37-48	interleukin 1 beta	Homo sapiens	249-257
19889203-0	2009	Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis.	Resveratrol	54-65	interleukin 1 beta	Homo sapiens	113-121
19889203-7	2009	The aim of this study was to investigate the potential synergistic effects of curcumin and resveratrol on IL-1beta-stimulated human chondrocytes in vitro using immunoblotting and electron microscopy.	Curcumin	78-86	interleukin 1 beta	Homo sapiens	106-114
19889203-7	2009	The aim of this study was to investigate the potential synergistic effects of curcumin and resveratrol on IL-1beta-stimulated human chondrocytes in vitro using immunoblotting and electron microscopy.	Resveratrol	91-102	interleukin 1 beta	Homo sapiens	106-114
19889203-9	2009	IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.	Resveratrol	91-102	interleukin 1 beta	Homo sapiens	0-8
19889203-10	2009	The modulatory effects of curcumin and resveratrol on IL-1beta-induced expression of cartilage specific matrix and proinflammatory enzymes were mediated in part by the cartilage-specific transcription factor Sox-9.	Curcumin	26-34	interleukin 1 beta	Homo sapiens	54-62
19889203-10	2009	The modulatory effects of curcumin and resveratrol on IL-1beta-induced expression of cartilage specific matrix and proinflammatory enzymes were mediated in part by the cartilage-specific transcription factor Sox-9.	Resveratrol	39-50	interleukin 1 beta	Homo sapiens	54-62
19068102-10	2009	Poor responders to topical budesonide exhibit higher levels of IL-1beta, ICAM-1 and nuclear factor (NF)-kappaB at diagnosis and higher expression of both IL-1beta and GR-beta after treatment.	Budesonide	27-37	interleukin 1 beta	Homo sapiens	63-71
19068102-10	2009	Poor responders to topical budesonide exhibit higher levels of IL-1beta, ICAM-1 and nuclear factor (NF)-kappaB at diagnosis and higher expression of both IL-1beta and GR-beta after treatment.	Budesonide	27-37	interleukin 1 beta	Homo sapiens	154-162
19068102-2	2009	OBJECTIVES: The objectives of this study were to observe the effect of budesonide on the expression of IL-1beta, TNF-alpha, granulocyte macrophage-colony stimulating factor, intercellular adhesion molecule (ICAM)-1, basic fibroblast growth factor, eotaxin-2, glucocorticoid receptor (GR)-alpha, GR-beta, c-Fos and p65 in nasal polyps and to correlate their expression to clinical response.	Budesonide	71-81	interleukin 1 beta	Homo sapiens	103-111
19673687-0	2009	Modulation of the ATP-lnduced release and processing of IL-1beta in microglial cells.	Adenosine Triphosphate	18-21	interleukin 1 beta	Homo sapiens	56-64
18990525-6	2009	After stimulation by the heat-killed isolate, concentrations of TNF-alpha were decreased by serum drawn from all patients; IL-1beta was increased after addition of serum of groups I, II, and V. It is concluded that CSF and serum of patients administered moxifloxacin may effectively modulate the production of pro- and anti-inflammatory cytokines by human monocytes.	Moxifloxacin	254-266	interleukin 1 beta	Homo sapiens	123-131
19551959-4	2009	The treatment with biltricid allow to decrease the TNF alpha, IL-1beta, IL-8 levels and to increase IL-4 level, especially in patients with combination of chronic opisthorhosis and Helicobacter pylori associated gastritis.	biltricid	19-28	interleukin 1 beta	Homo sapiens	62-70
19327235-6	2009	RESULTS: Bortezomib proved to be a rapid (&lt;24 hour) and potent inhibitor of the release of several NFkappaB-inducible cytokines (including TNF-alpha, IL-1Beta, IL-6 and IL-10) by activated T-cells from healthy volunteers and RA patients, regardless of their clinical responsiveness to methotrexate.	Bortezomib	9-19	interleukin 1 beta	Homo sapiens	153-161
19444759-0	2009	IL-1beta stimulates the expression of prostaglandin receptor EP4 in human chondrocytes by increasing production of prostaglandin E2.	Dinoprostone	115-131	interleukin 1 beta	Homo sapiens	0-8
19444759-6	2009	IL-1beta treatment caused a marked dose- and time-dependent increase in the levels of PGE(2), COX-2, and EP4 as compared with the untreated control.	Prostaglandins E	86-89	interleukin 1 beta	Homo sapiens	0-8
19444759-10	2009	IL-1beta increases the production of PGE(2), COX-2, and the PG receptor EP4 in cultured human chondrocytes.	Prostaglandins E	37-40	interleukin 1 beta	Homo sapiens	0-8
19276636-6	2009	The concentrations of TNF-alpha and IL-1beta secreted by THP-1 cells were detected when incubated with different doses of muscovite.	muscovite	122-131	interleukin 1 beta	Homo sapiens	36-44
19241361-7	2009	RESULTS: During CPFA, the fall in serum TNF-alpha and rise in serum IL-1Ra coincided with the rise in ratios of sTNFR2/TNF-alpha and IL-1Ra/IL-1beta (p&lt;0.05), which were different from those seen within HVHF (p&lt;0.05).	cpfa	16-20	interleukin 1 beta	Homo sapiens	140-148
19301089-14	2009	In conclusion risedronate could improve osteoporosis by increasing osteoprotegerin and reducing RANKL and IL-1beta.	Risedronic Acid	14-25	interleukin 1 beta	Homo sapiens	106-114
18686109-4	2009	While pure phenolics at the concentration of 20 mM did not significantly affect PBMC cytokine secretion, BTE and Polyphenon 60 suppressed interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6.	polyphenon	113-123	interleukin 1 beta	Homo sapiens	138-185
19301089-11	2009	In group 1 (risedronate plus calcium/vitamin D-treated patients), serum levels of RANKL and IL-1beta significantly decreased and the level of osteoprotegerin significantly increased after three and 6 months, but no significant difference was found in TNF-alpha level.	Risedronic Acid	12-23	interleukin 1 beta	Homo sapiens	92-100
19494504-11	2009	Eotaxin-induced production of IL-1beta, IL-6, and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	107-114	interleukin 1 beta	Homo sapiens	30-38
19494504-11	2009	Eotaxin-induced production of IL-1beta, IL-6, and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002.	SB 203580	135-143	interleukin 1 beta	Homo sapiens	30-38
19494504-11	2009	Eotaxin-induced production of IL-1beta, IL-6, and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	interleukin 1 beta	Homo sapiens	30-38
19494504-12	2009	In contrast, the GSK-3 inhibitor SB216763 blocked only IL-1beta production from the eosinophils.	SB 216763	33-41	interleukin 1 beta	Homo sapiens	55-63
18840637-7	2009	The induction of 11beta-HSD1 by IL-1beta was further increased by cortisol, whereas the induction of cyclooxygenase 2 by IL-1beta was inhibited by cortisol.	Hydrocortisone	66-74	interleukin 1 beta	Homo sapiens	32-40
19301089-11	2009	In group 1 (risedronate plus calcium/vitamin D-treated patients), serum levels of RANKL and IL-1beta significantly decreased and the level of osteoprotegerin significantly increased after three and 6 months, but no significant difference was found in TNF-alpha level.	Calcium	29-36	interleukin 1 beta	Homo sapiens	92-100
20107610-4	2009	Significant inhibition of IL-1beta responses was achieved with BTE and RSV, with the largest decrease of IL-6 and TF seen in HCAEC.	Resveratrol	71-74	interleukin 1 beta	Homo sapiens	26-34
20160900-3	2009	Bromoenol lactone (BEL), an inhibitor that was originally used to support a role for iPLA2 in the secretion of IL-1 beta, prevented caspase-1 activation induced by LPS and ATP as described, and also activation triggered by Salmonella infection and cytosolic flagellin, which rely on the Nlrc4 inflammasome.	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	0-17	interleukin 1 beta	Homo sapiens	111-120
20160900-3	2009	Bromoenol lactone (BEL), an inhibitor that was originally used to support a role for iPLA2 in the secretion of IL-1 beta, prevented caspase-1 activation induced by LPS and ATP as described, and also activation triggered by Salmonella infection and cytosolic flagellin, which rely on the Nlrc4 inflammasome.	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	19-22	interleukin 1 beta	Homo sapiens	111-120
20160900-3	2009	Bromoenol lactone (BEL), an inhibitor that was originally used to support a role for iPLA2 in the secretion of IL-1 beta, prevented caspase-1 activation induced by LPS and ATP as described, and also activation triggered by Salmonella infection and cytosolic flagellin, which rely on the Nlrc4 inflammasome.	Adenosine Triphosphate	172-175	interleukin 1 beta	Homo sapiens	111-120
19343193-3	2009	In this study, we found that ketamine (100 and 250 microM) concentration-dependently inhibited lipopolysaccharide (LPS)-induced NO and IL-1beta release in primary cultured microglia.	Ketamine	29-37	interleukin 1 beta	Homo sapiens	135-143
18562219-10	2009	Transfection of OA chondrocytes with MK2 siRNA antisense significantly reduced both basal and IL-1beta induced PGE2 release.	Dinoprostone	111-115	interleukin 1 beta	Homo sapiens	94-102
18602931-5	2009	A-804598 also potently blocked agonist stimulated release of IL-1beta and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.	2-cyano-1-((1S)-1-phenylethyl)-3-quinolin-5-ylguanidine	0-8	interleukin 1 beta	Homo sapiens	61-69
19365148-6	2009	GC sensitivity was assessed in vitro as the ability of DEX to inhibit lipopolysaccharide-stimulated production of the cytokines interleukin 1-beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in a whole-blood assay.	Dexamethasone	55-58	interleukin 1 beta	Homo sapiens	128-146
19365148-6	2009	GC sensitivity was assessed in vitro as the ability of DEX to inhibit lipopolysaccharide-stimulated production of the cytokines interleukin 1-beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in a whole-blood assay.	Dexamethasone	55-58	interleukin 1 beta	Homo sapiens	148-156
19365148-8	2009	Also, after DEX in vivo, low-cortisol men showed lower inhibition of IL-1beta and IL-6, both compared to the high-cortisol group and their own baseline levels.	Dexamethasone	12-15	interleukin 1 beta	Homo sapiens	69-77
20221418-9	2009	Pre-injection of AP-5 (10 pmol) and MK-801 (20 pmol), two NMDA receptor antagonists, significantly attenuated IL-1beta-induced hyperalgesia (p&lt;0.05).	2-amino-5-phosphopentanoic acid	17-21	interleukin 1 beta	Homo sapiens	110-118
20221418-9	2009	Pre-injection of AP-5 (10 pmol) and MK-801 (20 pmol), two NMDA receptor antagonists, significantly attenuated IL-1beta-induced hyperalgesia (p&lt;0.05).	Dizocilpine Maleate	36-42	interleukin 1 beta	Homo sapiens	110-118
20221418-11	2009	Excitotoxic lesions of the rostral ventromedial medulla with ibotenic acid (2 mug) abolished IL-1beta-induced contralateral hyperalgesia, suggesting a contribution of descending facilitatory drive.	Ibotenic Acid	61-74	interleukin 1 beta	Homo sapiens	93-101
19081189-3	2009	Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.	Carrageenan	136-147	interleukin 1 beta	Homo sapiens	385-394
19081189-3	2009	Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.	Carrageenan	195-206	interleukin 1 beta	Homo sapiens	365-383
19081189-3	2009	Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.	Carrageenan	195-206	interleukin 1 beta	Homo sapiens	385-394
19081189-3	2009	Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.	Carrageenan	136-147	interleukin 1 beta	Homo sapiens	365-383
19081189-3	2009	Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.	Carrageenan	195-206	interleukin 1 beta	Homo sapiens	365-383
19081189-3	2009	Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.	Carrageenan	195-206	interleukin 1 beta	Homo sapiens	385-394
19370157-6	2009	Interestingly, below this threshold, DCS inhibits the interleukin-1beta (IL-1beta)-induced pro-inflammatory gene expression, with the degree of suppression depending on the magnitude of DCS.	Cycloserine	37-40	interleukin 1 beta	Homo sapiens	54-71
19325908-6	2009	Analysis of E(h) Cys/CySS and IL-1beta in human plasma revealed a significant positive association between oxidized E(h) Cys/CySS and IL-1beta after controlling for age, gender, and BMI (P&lt;0.001).	cyss	21-25	interleukin 1 beta	Homo sapiens	134-142
19325908-6	2009	Analysis of E(h) Cys/CySS and IL-1beta in human plasma revealed a significant positive association between oxidized E(h) Cys/CySS and IL-1beta after controlling for age, gender, and BMI (P&lt;0.001).	Cysteine	121-124	interleukin 1 beta	Homo sapiens	134-142
19325908-6	2009	Analysis of E(h) Cys/CySS and IL-1beta in human plasma revealed a significant positive association between oxidized E(h) Cys/CySS and IL-1beta after controlling for age, gender, and BMI (P&lt;0.001).	cyss	125-129	interleukin 1 beta	Homo sapiens	134-142
19370157-6	2009	Interestingly, below this threshold, DCS inhibits the interleukin-1beta (IL-1beta)-induced pro-inflammatory gene expression, with the degree of suppression depending on the magnitude of DCS.	Cycloserine	37-40	interleukin 1 beta	Homo sapiens	73-81
19370157-6	2009	Interestingly, below this threshold, DCS inhibits the interleukin-1beta (IL-1beta)-induced pro-inflammatory gene expression, with the degree of suppression depending on the magnitude of DCS.	Cycloserine	186-189	interleukin 1 beta	Homo sapiens	54-71
19370157-6	2009	Interestingly, below this threshold, DCS inhibits the interleukin-1beta (IL-1beta)-induced pro-inflammatory gene expression, with the degree of suppression depending on the magnitude of DCS.	Cycloserine	186-189	interleukin 1 beta	Homo sapiens	73-81
19370157-7	2009	This suppression of NOS2 by DCS correlates with the attenuation of the NF-kappaB signaling pathway as measured by IL-1beta-induced phosphorylation of the inhibitor of kappa B (IkappaB)-alpha, degradation of IkappaB-alpha and IkappaB-beta, and subsequent nuclear translocation of NF-kappaB p65.	Cycloserine	28-31	interleukin 1 beta	Homo sapiens	114-122
19370157-8	2009	A mathematical model developed to understand the complex dynamics of the system predicts two thresholds in the magnitudes of DCS, one for the inhibition of IL-1beta-induced expression of NOS2 by DCS at low magnitudes, and second for the DCS-induced expression of NOS2 at higher magnitudes.	Cycloserine	125-128	interleukin 1 beta	Homo sapiens	156-164
19370157-8	2009	A mathematical model developed to understand the complex dynamics of the system predicts two thresholds in the magnitudes of DCS, one for the inhibition of IL-1beta-induced expression of NOS2 by DCS at low magnitudes, and second for the DCS-induced expression of NOS2 at higher magnitudes.	Cycloserine	195-198	interleukin 1 beta	Homo sapiens	156-164
19370157-8	2009	A mathematical model developed to understand the complex dynamics of the system predicts two thresholds in the magnitudes of DCS, one for the inhibition of IL-1beta-induced expression of NOS2 by DCS at low magnitudes, and second for the DCS-induced expression of NOS2 at higher magnitudes.	Cycloserine	195-198	interleukin 1 beta	Homo sapiens	156-164
19056796-0	2009	Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts.	cordycepin	0-10	interleukin 1 beta	Homo sapiens	20-28
19056796-3	2009	In this study, we aimed at the inhibitory effect of cordycepin on IL-1beta-induced MMP-1 and MMP-3 expression as well as the molecular basis using RA synovial fibroblasts (RASFs).	cordycepin	52-62	interleukin 1 beta	Homo sapiens	66-74
19056796-9	2009	RESULTS: Cordycepin inhibited IL-1beta-induced MMP-1 and MMP-3 expressions in RASFs in a dose-dependent manner.	cordycepin	9-19	interleukin 1 beta	Homo sapiens	30-38
19056796-11	2009	Moreover, cordycepin significantly inhibited IL-1beta-induced p38/JNK and AP-1 activation, but not extracellular signal-regulated kinase (ERK) and NF-kappaB activation.	cordycepin	10-20	interleukin 1 beta	Homo sapiens	45-53
19056796-12	2009	CONCLUSIONS: Cordycepin is a potent inhibitor of IL-1beta-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs.	cordycepin	13-23	interleukin 1 beta	Homo sapiens	49-57
18834941-1	2009	AIMS: To determine how sirolimus (SRL), in comparison to calcineurin inhibitors (CNI), influences gene expression of cytokines: interleukin 1beta, tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), and interleukin 10 (IL-10) in peripheral blood mononuclear cells (PBMC) of transplant recipients.	Sirolimus	23-32	interleukin 1 beta	Homo sapiens	128-145
19670527-13	2009	The former predicts, that Il-1 influences the tissue, stimulating them to the synthesis, via the cyclooxygenases (COX) activation, and release molecules such as prostaglandines (especially PGE2), which have the ability to penetrate the brain barrier.	Prostaglandins E	161-176	interleukin 1 beta	Homo sapiens	26-30
19670527-13	2009	The former predicts, that Il-1 influences the tissue, stimulating them to the synthesis, via the cyclooxygenases (COX) activation, and release molecules such as prostaglandines (especially PGE2), which have the ability to penetrate the brain barrier.	Dinoprostone	189-193	interleukin 1 beta	Homo sapiens	26-30
19921973-9	2009	A concave quadratic equation described the associations between plasma venlafaxine concentrations and IL1beta (P=0.03), TNFalpha (P=0.09), and MCP-1 (P=0.02), suggesting that these biomarkers may have become selectively lowered in the serotonergic dose range of venlafaxine.	Venlafaxine Hydrochloride	71-82	interleukin 1 beta	Homo sapiens	102-109
19074288-3	2008	Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol &gt; gamma-tocopherol &gt;&gt; alpha- or beta-tocopherol.	Vitamin E	18-27	interleukin 1 beta	Homo sapiens	95-103
19671357-8	2009	Moreover, IL-1beta also significantly increased NO production in supernatant (P&lt;0.01) and these effects could be significantly blocked by cotreatment with L-NMMA (10(-3) mol/L, all P&lt;0.01).	omega-N-Methylarginine	158-164	interleukin 1 beta	Homo sapiens	10-18
19074288-3	2008	Here we find that vitamin E forms differentially inhibit COX-2-catalyzed prostaglandin E(2) in IL-1beta-stimulated A549 cells without affecting COX-2 expression, showing the relative potency of gamma-tocotrienol approximately delta-tocopherol &gt; gamma-tocopherol &gt;&gt; alpha- or beta-tocopherol.	Dinoprostone	73-91	interleukin 1 beta	Homo sapiens	95-103
18929641-2	2008	Interleukin-1beta, flagellin, interferon-gamma, and tumor necrosis factor alpha (TNF-alpha) similarly induced Nox1 in a colon cancer cell line (T84), whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide-producing activity by ninefold.	Superoxides	209-219	interleukin 1 beta	Homo sapiens	0-17
19109489-4	2008	IL-1beta acts in a p38 mitogen-activated protein kinase (p38 MAP kinase)-dependent manner, to increase the excitability of nociceptors by relieving resting slow inactivation of tetrodotoxin-resistant voltage-gated sodium channels and also enhances persistent TTX-resistant current near threshold.	Tetrodotoxin	177-189	interleukin 1 beta	Homo sapiens	0-8
19109489-4	2008	IL-1beta acts in a p38 mitogen-activated protein kinase (p38 MAP kinase)-dependent manner, to increase the excitability of nociceptors by relieving resting slow inactivation of tetrodotoxin-resistant voltage-gated sodium channels and also enhances persistent TTX-resistant current near threshold.	Tetrodotoxin	259-262	interleukin 1 beta	Homo sapiens	0-8
18926575-3	2008	Quercetin reduced, in a dose-dependent manner, the proliferation of PBMC and modulated the level of IL-1beta and TNF-alpha released by PBMC in the culture supernatants.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	100-108
18606398-7	2008	Since these gene products are regulated by the transcription factor NF-kappaB, we investigated the effects of resveratrol on IL-1beta-induced NF-kappaB signaling pathway.	Resveratrol	110-121	interleukin 1 beta	Homo sapiens	125-133
18849440-5	2008	Concurrent treatment with IL-1beta (&lt;or=10 ng/ml) significantly accelerated migration in primary differentiated cells and in the 16HBE14o(-) cell line but did not accelerate migration in primary differentiated AEC collected from asthmatic donors.	16hbe14o	132-140	interleukin 1 beta	Homo sapiens	26-34
19448967-2	2009	This study aimed to examine effects of corpus atrophy and the genotypes of genes related to peptic ulcer, including IL-1beta, on risk of aspirin ulcer.	Aspirin	137-144	interleukin 1 beta	Homo sapiens	116-124
19090996-6	2008	Activation of microglial NADPH oxidase causes neurotoxicity through two mechanisms: 1) extracellular ROS produced by microglia are directly toxic to neurons; 2) intracellular ROS function as a signaling mechanism in microglia to amplify the production of several pro-inflammatory and neurotoxic cytokines (for example, tumor necrosis factor-alpha, prostaglandin E2, and interleukin-1beta).	Reactive Oxygen Species	175-178	interleukin 1 beta	Homo sapiens	370-387
18606398-0	2008	Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	23-40
18606398-6	2008	In this study we provide experimental evidence that resveratrol inhibits the expression of VEGF, MMP-3, MMP-9 and COX-2 in human articular chondrocytes stimulated with the pro-inflammatory cytokine IL-1beta.	Resveratrol	52-63	interleukin 1 beta	Homo sapiens	198-206
18606398-8	2008	Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	61-69
18606398-8	2008	Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.	acetylleucyl-leucyl-norleucinal	18-42	interleukin 1 beta	Homo sapiens	61-69
18606398-9	2008	Furthermore, we observed that resveratrol as well as ALLN inhibited IL-1beta-induced apoptosis, caspase-3 activation and PARP cleavage in human articular chondrocytes.	Resveratrol	30-41	interleukin 1 beta	Homo sapiens	68-76
18952671-5	2008	C2-ceramide, a cell permeable analog of ceramide, mimicked IL-1beta action suggesting that ceramide may be the second messenger of the proconvulsive effect of IL-1beta.	N-acetylsphingosine	0-11	interleukin 1 beta	Homo sapiens	59-67
18952671-5	2008	C2-ceramide, a cell permeable analog of ceramide, mimicked IL-1beta action suggesting that ceramide may be the second messenger of the proconvulsive effect of IL-1beta.	N-acetylsphingosine	0-11	interleukin 1 beta	Homo sapiens	159-167
18952671-5	2008	C2-ceramide, a cell permeable analog of ceramide, mimicked IL-1beta action suggesting that ceramide may be the second messenger of the proconvulsive effect of IL-1beta.	Ceramides	3-11	interleukin 1 beta	Homo sapiens	59-67
18952671-5	2008	C2-ceramide, a cell permeable analog of ceramide, mimicked IL-1beta action suggesting that ceramide may be the second messenger of the proconvulsive effect of IL-1beta.	Ceramides	3-11	interleukin 1 beta	Homo sapiens	159-167
18952671-5	2008	C2-ceramide, a cell permeable analog of ceramide, mimicked IL-1beta action suggesting that ceramide may be the second messenger of the proconvulsive effect of IL-1beta.	Ceramides	40-48	interleukin 1 beta	Homo sapiens	59-67
18952671-5	2008	C2-ceramide, a cell permeable analog of ceramide, mimicked IL-1beta action suggesting that ceramide may be the second messenger of the proconvulsive effect of IL-1beta.	Ceramides	40-48	interleukin 1 beta	Homo sapiens	159-167
18952671-7	2008	The proconvulsive IL-1beta effect was associated with increased Tyr(418) phosphorylation of Src-family of kinases indicative of its activation, and Tyr(1472) phosphorylation of one of its substrate, the NR2B subunit of the N-methyl-d-aspartate receptor, which were prevented by 3-O-MS and CGP76030.	Tyrosine	64-67	interleukin 1 beta	Homo sapiens	18-26
18952671-7	2008	The proconvulsive IL-1beta effect was associated with increased Tyr(418) phosphorylation of Src-family of kinases indicative of its activation, and Tyr(1472) phosphorylation of one of its substrate, the NR2B subunit of the N-methyl-d-aspartate receptor, which were prevented by 3-O-MS and CGP76030.	Tyrosine	148-151	interleukin 1 beta	Homo sapiens	18-26
18952671-8	2008	Finally, the proconvulsive effect of IL-1beta was blocked by ifenprodil, a selective NR2B receptor antagonist.	ifenprodil	61-71	interleukin 1 beta	Homo sapiens	37-45
19180878-1	2008	OBJECTIVE: To elucidate the effect of interleukin-1 beta (IL-1 beta) on human growth hormone (hGH) gene expression in a rat somatotropic pituitary cell line MtT/S.	monooxyethylene trimethylolpropane tristearate	157-160	interleukin 1 beta	Homo sapiens	38-56
19180878-1	2008	OBJECTIVE: To elucidate the effect of interleukin-1 beta (IL-1 beta) on human growth hormone (hGH) gene expression in a rat somatotropic pituitary cell line MtT/S.	monooxyethylene trimethylolpropane tristearate	157-160	interleukin 1 beta	Homo sapiens	58-67
19180880-0	2008	Effects of rapamycin on intracellular cholesterol homeostasis of glomerular mesangial cell in the presence of interleukin-1 beta.	Sirolimus	11-20	interleukin 1 beta	Homo sapiens	110-128
19180880-0	2008	Effects of rapamycin on intracellular cholesterol homeostasis of glomerular mesangial cell in the presence of interleukin-1 beta.	Cholesterol	38-49	interleukin 1 beta	Homo sapiens	110-128
19180880-3	2008	The effects of rapamycin on interleukin-1 beta (IL-1 beta)-induced mRNA and protein changes of low-density lipoprotein receptor (LDLR) and ATP-binding cassette transporter A1 (ABCA1) were assayed by quantitative real-time PCR and Western blot.	Sirolimus	15-24	interleukin 1 beta	Homo sapiens	28-46
19180880-3	2008	The effects of rapamycin on interleukin-1 beta (IL-1 beta)-induced mRNA and protein changes of low-density lipoprotein receptor (LDLR) and ATP-binding cassette transporter A1 (ABCA1) were assayed by quantitative real-time PCR and Western blot.	Sirolimus	15-24	interleukin 1 beta	Homo sapiens	48-57
19180880-5	2008	RESULTS: Rapamycin had no significant influence on intracellular cholesterol concentration under normal condition, but it significantly decreased the intracellular cholesterol concentration in the presence of IL-1 beta.	Sirolimus	9-18	interleukin 1 beta	Homo sapiens	209-218
19180880-5	2008	RESULTS: Rapamycin had no significant influence on intracellular cholesterol concentration under normal condition, but it significantly decreased the intracellular cholesterol concentration in the presence of IL-1 beta.	Cholesterol	164-175	interleukin 1 beta	Homo sapiens	209-218
19180880-6	2008	Rapamycin dose-dependently suppressed the increased expression of LDLR induced by IL-1 beta and up-regulated the suppressed expression of ABCA1 caused by IL-1 beta.	Sirolimus	0-9	interleukin 1 beta	Homo sapiens	82-91
19180880-6	2008	Rapamycin dose-dependently suppressed the increased expression of LDLR induced by IL-1 beta and up-regulated the suppressed expression of ABCA1 caused by IL-1 beta.	Sirolimus	0-9	interleukin 1 beta	Homo sapiens	154-163
18990074-5	2008	RESULTS/CONCLUSIONS: To produce IL-1 beta, macrophages need a double stimulation with Toll like receptor (TLR) ligands that induce gene transcription, and NLR agonists (such as ATP or muramyl dipeptide (MDP)) that activate the inflammasome.	Adenosine Triphosphate	177-180	interleukin 1 beta	Homo sapiens	32-41
18990074-5	2008	RESULTS/CONCLUSIONS: To produce IL-1 beta, macrophages need a double stimulation with Toll like receptor (TLR) ligands that induce gene transcription, and NLR agonists (such as ATP or muramyl dipeptide (MDP)) that activate the inflammasome.	Acetylmuramyl-Alanyl-Isoglutamine	184-201	interleukin 1 beta	Homo sapiens	32-41
18990074-5	2008	RESULTS/CONCLUSIONS: To produce IL-1 beta, macrophages need a double stimulation with Toll like receptor (TLR) ligands that induce gene transcription, and NLR agonists (such as ATP or muramyl dipeptide (MDP)) that activate the inflammasome.	Acetylmuramyl-Alanyl-Isoglutamine	203-206	interleukin 1 beta	Homo sapiens	32-41
19022976-7	2008	Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P &lt; 0.01).	Arginine	0-3	interleukin 1 beta	Homo sapiens	58-66
18791174-4	2008	Effects of tunicamycin and thapsigargin on IL-1beta- and TNF-alpha-stimulated MCP-1 mRNA expression and protein production were further examined by RT-PCR and ELISA, respectively.	Tunicamycin	11-22	interleukin 1 beta	Homo sapiens	43-51
18791174-4	2008	Effects of tunicamycin and thapsigargin on IL-1beta- and TNF-alpha-stimulated MCP-1 mRNA expression and protein production were further examined by RT-PCR and ELISA, respectively.	Thapsigargin	27-39	interleukin 1 beta	Homo sapiens	43-51
19022976-7	2008	Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P &lt; 0.01).	Glutamine	10-13	interleukin 1 beta	Homo sapiens	58-66
19053923-8	2008	RESULTS: In the univariate analysis, allele 2 of IL-1B+3954 and IL-1B-511 was associated with ABL (P = 0.040 and P = 0.039, respectively), whereas no association was found with allele 2 of IL-1A+4845 or IL-1RN variable number tandem repeat (VNTR) (P = 0.445 and P = 0.375, respectively).	lauric acid	94-97	interleukin 1 beta	Homo sapiens	49-54
19053923-8	2008	RESULTS: In the univariate analysis, allele 2 of IL-1B+3954 and IL-1B-511 was associated with ABL (P = 0.040 and P = 0.039, respectively), whereas no association was found with allele 2 of IL-1A+4845 or IL-1RN variable number tandem repeat (VNTR) (P = 0.445 and P = 0.375, respectively).	lauric acid	94-97	interleukin 1 beta	Homo sapiens	64-69
18838388-9	2008	CONCLUSIONS: There may be a protective effect in RA from the IL-1B (-1464 C/G) G variant.	Radium	49-51	interleukin 1 beta	Homo sapiens	61-66
19053923-9	2008	A lower ABL was associated with the occurrence of allele 2 of IL-1B-511.	lauric acid	8-11	interleukin 1 beta	Homo sapiens	62-67
19053923-10	2008	The multiple logistic regression analysis also showed a significant association of allele 1 of IL-1B-511 with high ABL (P = 0.049) and of allele 2 of IL-1A+4845 with high ABL among individuals with CHD (P = 0.050).	lauric acid	115-118	interleukin 1 beta	Homo sapiens	95-100
18547825-8	2008	In cultured chondrocytes, both NSAID decreased COX-2 and mPGES-1 synthesis and prostaglandin E2 (PGE2) release induced by IL-1beta, while no effect was observed on nitric oxide or iNOS synthesis.	Dinoprostone	79-95	interleukin 1 beta	Homo sapiens	122-130
18547825-8	2008	In cultured chondrocytes, both NSAID decreased COX-2 and mPGES-1 synthesis and prostaglandin E2 (PGE2) release induced by IL-1beta, while no effect was observed on nitric oxide or iNOS synthesis.	Dinoprostone	97-101	interleukin 1 beta	Homo sapiens	122-130
18776065-8	2008	Pamapimod also inhibited lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) alpha production by monocytes, interleukin (IL)-1beta production in human whole blood, and spontaneous TNFalpha production by synovial explants from RA patients.	pamapimod	0-9	interleukin 1 beta	Homo sapiens	120-142
18547825-9	2008	In OA patients, only CBX decreased tumor necrosis factor alpha and IL-1beta expression in the cartilage, while both NSAID diminished IL-1beta induced cytokine synthesis in cultured OA chondrocytes.	Carboxin	21-24	interleukin 1 beta	Homo sapiens	67-75
18838388-6	2008	RESULTS: The IL-1B (-1464 C/G) G allele was found to be less common in the RA group [P = 0.01; odds ratio (OR) 1.24; 95% CI 1.04, 1.48].	Radium	75-77	interleukin 1 beta	Homo sapiens	13-18
18838388-11	2008	Further meta-analysis revealed IL-1B (-511 A/G) to be associated with increased susceptibility to RA.	Radium	98-100	interleukin 1 beta	Homo sapiens	31-36
19055699-7	2008	CBA confirmed upregulation of IL-8 and show upregulation of IL-1beta in the tumours (P &lt; 0.05).	cba	0-3	interleukin 1 beta	Homo sapiens	60-68
18603357-6	2008	IL-1B -31T/C polymorphism may modify HCC risk in relation to alcohol intake or smoking.	Alcohols	61-68	interleukin 1 beta	Homo sapiens	0-5
18809379-7	2008	NS-398 inhibited proliferation of IL-1beta-stimulated VSMC in a HbO(2)-sensitive manner.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	34-42
18809379-8	2008	In conclusion, NS-398 inhibits proliferation of IL-1beta-stimulated VSMC by HO-1-derived CO.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	15-21	interleukin 1 beta	Homo sapiens	48-56
19032770-2	2008	A variety of effects have been described for different cell types; hepatocyte lipid turnover pathways are inhibited during inflammation, whereas interleukin-1beta (IL-1beta) reduces intracellular cholesterol levels in fibroblasts.	Cholesterol	196-207	interleukin 1 beta	Homo sapiens	145-162
19032770-2	2008	A variety of effects have been described for different cell types; hepatocyte lipid turnover pathways are inhibited during inflammation, whereas interleukin-1beta (IL-1beta) reduces intracellular cholesterol levels in fibroblasts.	Cholesterol	196-207	interleukin 1 beta	Homo sapiens	164-172
19032770-8	2008	Addition of exogenous IL-1beta resulted in a dose-dependent retention of intracellular cholesterol and triglycerides.	Cholesterol	87-98	interleukin 1 beta	Homo sapiens	22-30
19032770-8	2008	Addition of exogenous IL-1beta resulted in a dose-dependent retention of intracellular cholesterol and triglycerides.	Triglycerides	103-116	interleukin 1 beta	Homo sapiens	22-30
19115937-6	2008	The results demonstrate that cmvIL-10 does inhibit NF-kappaB activation, as evidenced by reduced degradation of the NF-kappaB inhibitor IkappaB-alpha, and decreased transcription of the NF-kappaB-responsive genes tumor necrosis factor-alpha (TNF-alpha) and IL-1beta.	cmvil-10	29-37	interleukin 1 beta	Homo sapiens	257-265
18809379-0	2008	NS-398, a selective COX-2 inhibitor, inhibits proliferation of IL-1beta-stimulated vascular smooth muscle cells by induction of HO-1.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	63-71
18809379-1	2008	We investigated whether NS-398, a selective inhibitor of COX-2, induces HO-1 in IL-1beta-stimulated vascular smooth muscle cells (VSMC).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	24-30	interleukin 1 beta	Homo sapiens	80-88
18841975-9	2008	These results suggest that the suppressions of the expressions of iNOS, COX-2, TNF-alpha, and IL-1beta via NF-kappaB inactivation are responsible for the anti-inflammatory effects of sinapic acid.	sinapinic acid	183-195	interleukin 1 beta	Homo sapiens	94-102
18954530-0	2008	Resveratrol protects bone marrow mesenchymal stem cell derived chondrocytes cultured on chitosan-gelatin scaffolds from the inhibitory effect of interleukin-1beta.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	145-162
18841975-2	2008	Sinapic acid inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E 2 (PGE 2), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta production in a dose-dependent manner.	sinapinic acid	0-12	interleukin 1 beta	Homo sapiens	141-163
18841975-3	2008	Consistent with these findings, sinapic acid inhibited LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygase (COX)-2 at the protein levels, and iNOS, COX-2, TNF-alpha, and IL-1beta mRNA expression in RAW 264.7 macrophages, as determined by Western blotting and reverse-transcribed polymerase chain reaction, respectively.	sinapinic acid	32-44	interleukin 1 beta	Homo sapiens	201-209
18841975-4	2008	Sinapic acid suppressed the LPS-induced activation of nuclear factor-kappaB (NF-kappaB), a transcription factor pivotal necessary for pro-inflammatory mediators, such as iNOS, COX-2, TNF-alpha, and IL-1beta.	sinapinic acid	0-12	interleukin 1 beta	Homo sapiens	198-206
19014534-0	2008	IL-1beta differently involved in IL-8 and FGF-2 release in crystalline silica-treated lung cell co-cultures.	Silicon Dioxide	71-77	interleukin 1 beta	Homo sapiens	0-8
19014534-9	2008	However, exogenous IL-1beta reduced the FGF-2 levels, strongly elevated the FGF-2-binding protein PTX3, and prevented the reduction in the number of pneumocytes induced by silica.	Silicon Dioxide	172-178	interleukin 1 beta	Homo sapiens	19-27
19014534-10	2008	CONCLUSION: IL-1beta seems to be differently involved in the silica-induced release of IL-8 and FGF-2 in different lung cell cultures.	Silicon Dioxide	61-67	interleukin 1 beta	Homo sapiens	12-20
19014534-11	2008	Whereas the silica-induced IL-8 release is regulated via an IL-1-receptor-mediated mechanism, IL-1beta is suggested only indirectly to affect the silica-induced FGF-2 release by counteracting pneumocyte loss.	Silicon Dioxide	146-152	interleukin 1 beta	Homo sapiens	94-102
18954530-0	2008	Resveratrol protects bone marrow mesenchymal stem cell derived chondrocytes cultured on chitosan-gelatin scaffolds from the inhibitory effect of interleukin-1beta.	Chitosan	88-96	interleukin 1 beta	Homo sapiens	145-162
18954530-1	2008	AIM: To investigate the effects of resveratrol on interleukin-1beta (IL-1beta) induced catabolism in bone marrow mesenchymal stem cell (MSC) derived chondrocytes cultured on chitosan-gelatin scaffolds (CGS).	Resveratrol	35-46	interleukin 1 beta	Homo sapiens	50-67
18954530-1	2008	AIM: To investigate the effects of resveratrol on interleukin-1beta (IL-1beta) induced catabolism in bone marrow mesenchymal stem cell (MSC) derived chondrocytes cultured on chitosan-gelatin scaffolds (CGS).	Resveratrol	35-46	interleukin 1 beta	Homo sapiens	69-77
18954530-10	2008	A specific beta1-integrin blocking antibody abrogated the effects of resveratrol on IL-1beta stimulated MSC-derived chondrocytes.	Resveratrol	69-80	interleukin 1 beta	Homo sapiens	84-92
18954530-11	2008	CONCLUSION: These results indicated that resveratrol acts as a NF-kappaB inhibitor to protect MSC-derived chondrocytes on the CGS from the IL-1beta catabolism and these effects are mediated by beta1-integrin.	Resveratrol	41-52	interleukin 1 beta	Homo sapiens	139-147
18975308-1	2008	OBJECTIVE: To investigate the effects of prostaglandin D2 (PGD2) on interleukin-1beta (IL-1beta)-induced matrix metalloproteinase 1 (MMP-1) and MMP-13 expression in human chondrocytes and the signaling pathways involved in these effects.	Prostaglandin D2	59-63	interleukin 1 beta	Homo sapiens	68-85
18975348-9	2008	In vitro, treatment with fasudil or Y27632 decreased production of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 by synovial membrane cells, peripheral blood mononuclear cells, and fibroblast-like synoviocytes from patients with active RA.	fasudil	25-32	interleukin 1 beta	Homo sapiens	107-124
18975348-9	2008	In vitro, treatment with fasudil or Y27632 decreased production of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 by synovial membrane cells, peripheral blood mononuclear cells, and fibroblast-like synoviocytes from patients with active RA.	fasudil	25-32	interleukin 1 beta	Homo sapiens	126-134
18975348-9	2008	In vitro, treatment with fasudil or Y27632 decreased production of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 by synovial membrane cells, peripheral blood mononuclear cells, and fibroblast-like synoviocytes from patients with active RA.	Y 27632	36-42	interleukin 1 beta	Homo sapiens	107-124
18975348-9	2008	In vitro, treatment with fasudil or Y27632 decreased production of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-6 by synovial membrane cells, peripheral blood mononuclear cells, and fibroblast-like synoviocytes from patients with active RA.	Y 27632	36-42	interleukin 1 beta	Homo sapiens	126-134
18684863-3	2008	Here we show that inhibition of HMG-CoA reductase by simvastatin treatment, mimicking MKD, results in increased IL-1beta secretion in a Rac1/PI3K-dependent manner.	Simvastatin	53-64	interleukin 1 beta	Homo sapiens	112-120
18684863-4	2008	Simvastatin treatment was found to activate protein kinase B (PKB)/c-akt, a primary effector of PI3K, and ectopic expression of constitutively active PKB was sufficient to induce IL-1beta release.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	179-187
18684863-5	2008	The small GTPase Rac1 was activated by simvastatin, and this was required for both PKB activation and IL-1beta secretion.	Simvastatin	39-50	interleukin 1 beta	Homo sapiens	102-110
18684863-7	2008	These data suggest that, in MKD, dysregulated isoprenoid biosynthesis activates Rac1/PI3K/PKB, resulting in caspase-1 activation with increased IL-1beta release.	Terpenes	46-56	interleukin 1 beta	Homo sapiens	144-152
18996285-7	2008	RESULTS: NF-kappaB p65 antisense oligonucleotides resulted in downregulation of NF-kappaB p65 expression, blocked the expression of IL-1beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1beta and IL-8.	Oligonucleotides	33-49	interleukin 1 beta	Homo sapiens	132-140
18996285-7	2008	RESULTS: NF-kappaB p65 antisense oligonucleotides resulted in downregulation of NF-kappaB p65 expression, blocked the expression of IL-1beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1beta and IL-8.	Oligonucleotides	33-49	interleukin 1 beta	Homo sapiens	202-210
18587424-9	2008	PMX464 inhibited IL-1beta-induced NF-kappaB DNA binding, nuclear translocation of NF-kappaB p65 subunit and factors involved in NF-kappaB activation; specifically, IkappaBalpha degradation, IkappaB phosphorylation and IkappaB kinase (IKK) activity in A549.	PMX 464	0-6	interleukin 1 beta	Homo sapiens	17-25
18617366-3	2008	Predictors of fatigue included presence of at least one cytosine at IL1B -511 (95%CI=0.91-16.6, p=.007) and homozygosity for either variant of the IL6 -174 genotype (G/G or C/C; 95%CI=1.12-17.9, p=.027).	Cytosine	56-64	interleukin 1 beta	Homo sapiens	68-72
18757527-2	2008	Various single-nucleotide polymorphisms (SNPs) in apoptotic genes have been associated with increased risks in lung cancer, particularly FAS -1377 G&gt;A (rs2234767), FASLG -844 C&gt;T (rs763110), IL1B +3954 C&gt;T Phe105Phe (rs1143634) and BAT3 Ser625Pro (rs1052486).	ammonium ferrous sulfate	137-140	interleukin 1 beta	Homo sapiens	197-201
18764842-2	2008	OBJECTIVES: The aim of this study was to evaluate whether 3 months of monotherapy with chloroquine influences the mRNA skin expression of interleukin (IL)-1beta, IL-6 and tumour necrosis factor-alpha (TNF-alpha) in nonirradiated and locally ultraviolet B (UVB) irradiated nondiseased skin of patients with systemic lupus erythematosus (SLE).	Chloroquine	87-98	interleukin 1 beta	Homo sapiens	138-160
18975308-1	2008	OBJECTIVE: To investigate the effects of prostaglandin D2 (PGD2) on interleukin-1beta (IL-1beta)-induced matrix metalloproteinase 1 (MMP-1) and MMP-13 expression in human chondrocytes and the signaling pathways involved in these effects.	Prostaglandin D2	59-63	interleukin 1 beta	Homo sapiens	87-95
18764842-7	2008	Significantly lower expression of IL-1beta, IL-6 and TNF-alpha mRNAs was noted in irradiated skin samples after 3 months of chloroquine treatment.	Chloroquine	124-135	interleukin 1 beta	Homo sapiens	34-42
18823978-5	2008	Our results show that MMP-12 expression (mRNA and protein) is down regulated in IL-1beta-treated macrophages only in the presence of a specific PPARalpha agonist, GW647, in a dose-dependent manner.	gw647	163-168	interleukin 1 beta	Homo sapiens	80-88
19085374-7	2008	Besifloxacin significantly inhibited IL-1beta-induced cytokine release in a dose-dependent manner, with a comparable (IL-8) or better (G-CSF, GM-CSF, IL-6, MCP-1, MIP-1beta, TGF-alpha, and TNF-alpha) efficacy compared to moxifloxacin.	Moxifloxacin	221-233	interleukin 1 beta	Homo sapiens	37-45
19085374-2	2008	METHODS: Cytokine expression in primary HCEpiC was stimulated by interleukin-1beta (IL-1beta), and Luminex technology was used to determine the effect of besifloxacin on IL-1beta-induced cytokine release.	besifloxacin	154-166	interleukin 1 beta	Homo sapiens	170-178
19085374-7	2008	Besifloxacin significantly inhibited IL-1beta-induced cytokine release in a dose-dependent manner, with a comparable (IL-8) or better (G-CSF, GM-CSF, IL-6, MCP-1, MIP-1beta, TGF-alpha, and TNF-alpha) efficacy compared to moxifloxacin.	besifloxacin	0-12	interleukin 1 beta	Homo sapiens	37-45
18764914-7	2008	For EBC (test group), the postoperative values of IL-1-beta were significantly higher compared with day -1 (P = 0.005).	NSC638702	4-7	interleukin 1 beta	Homo sapiens	50-59
18618634-8	2008	In all groups, nicotine reduced LPS- and PHA (0.5 microg/mL)-stimulated production of IL1beta, IL10, TGFbeta, and TNFalpha (P &lt; 0.001).	Nicotine	15-23	interleukin 1 beta	Homo sapiens	86-93
18622761-3	2008	Croton oil, an inflammation inducer, induced transgenic GM-CSF and TNF-alpha promoter activities in skin epidermis 6-fold and 3.4-fold, respectively; however, it produced a less than 1.5-fold and 1.7-fold change in IL-1beta and IL-18 promoter activity, respectively.	Croton Oil	0-10	interleukin 1 beta	Homo sapiens	215-223
19084961-6	2008	With the treatment of Pg-LPS or E-LPS, the TNF-alpha and IL-1beta levels secreted by HGF-1 cells were remarkably increased with a single perk (P&lt;0.01) while a continuous enhancement of secretion by THP-1 cells was observed (P&lt;0.01).	pg-lps	22-28	interleukin 1 beta	Homo sapiens	57-65
19084961-6	2008	With the treatment of Pg-LPS or E-LPS, the TNF-alpha and IL-1beta levels secreted by HGF-1 cells were remarkably increased with a single perk (P&lt;0.01) while a continuous enhancement of secretion by THP-1 cells was observed (P&lt;0.01).	e-lps	32-37	interleukin 1 beta	Homo sapiens	57-65
18789903-13	2008	The reduction in IL-1beta-induced c-jun expression and subsequent binding of the c-jun/CREB1 complex to AP-1/CRE site mainly contributed to the inhibitory action of HE-145 on IL-1beta-induced MIP-1beta production.	Helium	165-167	interleukin 1 beta	Homo sapiens	17-25
18656550-7	2008	We have investigated the effect of the lung carcinogens cigarette-smoke condensate (CSC) and benzo[a]pyrene (B[a]P) on the promoters of the IL1B gene varying only at the site of the -31T/C polymorphism.	Benzo(a)pyrene	93-107	interleukin 1 beta	Homo sapiens	140-144
18789903-13	2008	The reduction in IL-1beta-induced c-jun expression and subsequent binding of the c-jun/CREB1 complex to AP-1/CRE site mainly contributed to the inhibitory action of HE-145 on IL-1beta-induced MIP-1beta production.	Helium	165-167	interleukin 1 beta	Homo sapiens	175-183
18789903-0	2008	Helioxanthin inhibits interleukin-1 beta-induced MIP-1 beta production by reduction of c-jun expression and binding of the c-jun/CREB1 complex to the AP-1/CRE site of the MIP-1 beta promoter in Huh7 cells.	helioxanthin	0-12	interleukin 1 beta	Homo sapiens	22-40
18720486-4	2008	Human endothelial cells and human monocyte-based activity screening showed that NI-NODs inhibit IL-1beta production, modulate PGE(2) production, and protect against apoptosis.	ni-nods	80-87	interleukin 1 beta	Homo sapiens	96-104
18789903-4	2008	Here, we demonstrated that HE-145 inhibited IL-1beta-induced MIP-1beta expression in a dose-dependent manner in Huh7 cells.	he-145	27-33	interleukin 1 beta	Homo sapiens	44-52
18789903-5	2008	To understand the mode of action of HE-145, we first examined how IL-1beta induced MIP-1beta expression at the molecular level.	Helium	36-38	interleukin 1 beta	Homo sapiens	66-74
18789903-10	2008	The inhibitory effect of HE-145 on IL-1beta-induced MIP-1beta promoter activity was completely reversed by overexpressing c-jun.	he-145	25-31	interleukin 1 beta	Homo sapiens	35-43
18772336-2	2008	Here we demonstrate that 4-HNE inhibits TNF and interleukin-1beta production in human monocytes in response to lipopolysaccharide.	4-hydroxy-2-nonenal	25-30	interleukin 1 beta	Homo sapiens	48-65
18658272-6	2008	Flagellin-, IL-1beta-, ATP-, and forskolin-stimulated I(Cl) were inhibited by cystic fibrosis transmembrane conductance regulator (CFTR) blockers GlyH101, CFTRinh172, and glibenclamide.	N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide	146-153	interleukin 1 beta	Homo sapiens	12-20
18658272-6	2008	Flagellin-, IL-1beta-, ATP-, and forskolin-stimulated I(Cl) were inhibited by cystic fibrosis transmembrane conductance regulator (CFTR) blockers GlyH101, CFTRinh172, and glibenclamide.	3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone	155-165	interleukin 1 beta	Homo sapiens	12-20
18658272-6	2008	Flagellin-, IL-1beta-, ATP-, and forskolin-stimulated I(Cl) were inhibited by cystic fibrosis transmembrane conductance regulator (CFTR) blockers GlyH101, CFTRinh172, and glibenclamide.	Glyburide	171-184	interleukin 1 beta	Homo sapiens	12-20
18827361-3	2008	Macrophages stimulated with OL or lipid A sonically dissolved in saline released both interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	ol	28-30	interleukin 1 beta	Homo sapiens	86-103
18827361-3	2008	Macrophages stimulated with OL or lipid A sonically dissolved in saline released both interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	ol	28-30	interleukin 1 beta	Homo sapiens	105-113
18827361-3	2008	Macrophages stimulated with OL or lipid A sonically dissolved in saline released both interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	Sodium Chloride	65-71	interleukin 1 beta	Homo sapiens	86-103
18827361-3	2008	Macrophages stimulated with OL or lipid A sonically dissolved in saline released both interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	Sodium Chloride	65-71	interleukin 1 beta	Homo sapiens	105-113
18827361-4	2008	In contrast, macrophages stimulated with OL or lipid A sonically dissolved in ethanol or dimethyl sulfoxide (DMSO) secreted much TNF-alpha, but very little IL-1beta.	ol	41-43	interleukin 1 beta	Homo sapiens	156-164
18827361-4	2008	In contrast, macrophages stimulated with OL or lipid A sonically dissolved in ethanol or dimethyl sulfoxide (DMSO) secreted much TNF-alpha, but very little IL-1beta.	Lipid A	47-54	interleukin 1 beta	Homo sapiens	156-164
19138976-9	2008	A disruptor of the interaction between CREB-binding protein and transcription factors such as CREB and NF-kappaB, 2-naphthol-AS-E-phosphate (KG-501), inhibited IL-1beta-induced CXC chemokine gene expression and angiogenic activity in NSCLC.	2-naphthol-as-e-phosphate	114-139	interleukin 1 beta	Homo sapiens	160-168
18829596-7	2008	An increase in IL-1beta was seen on Day 14 in women with symptoms of depression (CES-D &gt; or = 11) on Day 28 compared to levels in women without depressive symptoms (F = 4.50, p = .045).	Cerium	81-84	interleukin 1 beta	Homo sapiens	15-23
18829596-7	2008	An increase in IL-1beta was seen on Day 14 in women with symptoms of depression (CES-D &gt; or = 11) on Day 28 compared to levels in women without depressive symptoms (F = 4.50, p = .045).	Deuterium	85-88	interleukin 1 beta	Homo sapiens	15-23
18769122-9	2008	Combination treatment of cells with both SAHA and cRA induced several transcripts with known anti-cancer/immunomodulatory effects, including dhrs9, gata3, il1beta, phlda1, txk and vhl.	Vorinostat	41-45	interleukin 1 beta	Homo sapiens	155-162
18769122-9	2008	Combination treatment of cells with both SAHA and cRA induced several transcripts with known anti-cancer/immunomodulatory effects, including dhrs9, gata3, il1beta, phlda1, txk and vhl.	Isotretinoin	50-53	interleukin 1 beta	Homo sapiens	155-162
18586117-3	2008	Increased levels of circulating pro-inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-12p70, and IL-6 have been observed in most of patients with CIU, together with an enhancement of IL-2 secretion following T-cell stimulation.	n-cyclohexyl-n'-(4-iodophenyl)urea	152-155	interleukin 1 beta	Homo sapiens	79-87
18556347-6	2008	IL-1beta- and IL-1beta plus leptin-induced hBD-2 production both were suppressed by antisense oligonucleotides against nuclear factor-kappaB (NF-kappaB) p50 and p65; the latter was also suppressed by antisense signal transducer and activator of transcription (STAT)1 and STAT3.	Oligonucleotides	94-110	interleukin 1 beta	Homo sapiens	0-8
18556347-6	2008	IL-1beta- and IL-1beta plus leptin-induced hBD-2 production both were suppressed by antisense oligonucleotides against nuclear factor-kappaB (NF-kappaB) p50 and p65; the latter was also suppressed by antisense signal transducer and activator of transcription (STAT)1 and STAT3.	Oligonucleotides	94-110	interleukin 1 beta	Homo sapiens	14-22
18556347-8	2008	The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin-induced hBD-2 production, IL-1beta-induced NF-kappaB activity, and leptin-induced STAT1 and STAT3 activity; contrastingly, the Janus kinase (JAK) 2 inhibitor AG490 suppressed IL-1beta plus leptin-induced hBD-2 production and leptin-induced STAT1 and STAT3 activity.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	23-31	interleukin 1 beta	Homo sapiens	43-52
18556347-8	2008	The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin-induced hBD-2 production, IL-1beta-induced NF-kappaB activity, and leptin-induced STAT1 and STAT3 activity; contrastingly, the Janus kinase (JAK) 2 inhibitor AG490 suppressed IL-1beta plus leptin-induced hBD-2 production and leptin-induced STAT1 and STAT3 activity.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	23-31	interleukin 1 beta	Homo sapiens	43-51
18556347-8	2008	The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin-induced hBD-2 production, IL-1beta-induced NF-kappaB activity, and leptin-induced STAT1 and STAT3 activity; contrastingly, the Janus kinase (JAK) 2 inhibitor AG490 suppressed IL-1beta plus leptin-induced hBD-2 production and leptin-induced STAT1 and STAT3 activity.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	23-31	interleukin 1 beta	Homo sapiens	57-65
18556347-8	2008	The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin-induced hBD-2 production, IL-1beta-induced NF-kappaB activity, and leptin-induced STAT1 and STAT3 activity; contrastingly, the Janus kinase (JAK) 2 inhibitor AG490 suppressed IL-1beta plus leptin-induced hBD-2 production and leptin-induced STAT1 and STAT3 activity.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	23-31	interleukin 1 beta	Homo sapiens	57-65
18556347-9	2008	IL-1beta induced serine phosphorylation of inhibitory kappaBalpha, STAT1, and STAT3.	Serine	17-23	interleukin 1 beta	Homo sapiens	0-8
18556347-11	2008	IL-1beta or leptin individually induced threonine/tyrosine phosphorylation of p38 MAPK, whereas only leptin induced tyrosine phosphorylation of JAK2, suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB, which is activated by IL-1beta.	Threonine	40-49	interleukin 1 beta	Homo sapiens	0-8
18556347-11	2008	IL-1beta or leptin individually induced threonine/tyrosine phosphorylation of p38 MAPK, whereas only leptin induced tyrosine phosphorylation of JAK2, suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB, which is activated by IL-1beta.	Tyrosine	50-58	interleukin 1 beta	Homo sapiens	0-8
18556347-11	2008	IL-1beta or leptin individually induced threonine/tyrosine phosphorylation of p38 MAPK, whereas only leptin induced tyrosine phosphorylation of JAK2, suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB, which is activated by IL-1beta.	Tyrosine	116-124	interleukin 1 beta	Homo sapiens	0-8
18677577-2	2008	In addition, ghrelin has anti-inflammatory effects, and it has been reported that ghrelin down-regulates pro-inflammatory cytokines, including interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	Ghrelin	82-89	interleukin 1 beta	Homo sapiens	143-165
18802115-5	2008	In fact, LPA alone significantly induced COX-2 expression and enhanced IL-1alpha- or IL-1beta-induced enzyme expression in a manner sensitive to pertussis toxin and Ki16425.	lysophosphatidic acid	9-12	interleukin 1 beta	Homo sapiens	85-93
18802048-6	2008	Our results suggest that gliadin and beta-glucan stimulate IL-23 secretion through induction of the IL-1 signaling pathway and reveal for the first time that the IL-1 system regulates IL-23 production.	beta-Glucans	37-48	interleukin 1 beta	Homo sapiens	100-104
18664535-0	2008	Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.	Glucose	168-175	interleukin 1 beta	Homo sapiens	10-32
18664535-0	2008	Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.	Glucose	168-175	interleukin 1 beta	Homo sapiens	140-148
18664535-2	2008	OBJECTIVE: The objective was to investigate IL-1beta mRNA expression in near-pure beta-cells of patients with type 2 diabetes (T2DM) and study the regulation of IL-1beta by glucose in isolated human islets.	Glucose	173-180	interleukin 1 beta	Homo sapiens	161-169
18664535-4	2008	Cultured human islets and fluorescence-activated cell sorter-purified human beta-cells were used to study the regulation of IL-1beta expression by glucose and IL-1beta.	Glucose	147-154	interleukin 1 beta	Homo sapiens	124-132
18664535-7	2008	In cultured human islets, IL-1beta mRNA and protein expression was induced by high glucose and IL-1beta autostimulation and decreased by the IL-1 receptor antagonist IL-1Ra.	Glucose	83-90	interleukin 1 beta	Homo sapiens	26-34
18664535-8	2008	The glucose response was negatively correlated with basal IL-1beta expression levels.	Glucose	4-11	interleukin 1 beta	Homo sapiens	58-66
18664535-10	2008	Glucose-induced IL-1beta was biologically active and stimulated IL-8 release.	Glucose	0-7	interleukin 1 beta	Homo sapiens	16-24
18664535-12	2008	CONCLUSION: Evidence that IL-1beta mRNA expression is up-regulated in beta-cells of patients with T2DM is presented, and glucose-promoted IL-1beta autostimulation may be a possible contributor.	Glucose	121-128	interleukin 1 beta	Homo sapiens	138-146
18802115-5	2008	In fact, LPA alone significantly induced COX-2 expression and enhanced IL-1alpha- or IL-1beta-induced enzyme expression in a manner sensitive to pertussis toxin and Ki16425.	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	165-172	interleukin 1 beta	Homo sapiens	85-93
18639562-6	2008	Clomipramine and imipramine also attenuated the expression of inducible nitric oxide synthase and proinflammatory cytokines such as interleukin-1beta and TNF-alpha at mRNA levels.	Clomipramine	0-12	interleukin 1 beta	Homo sapiens	132-149
18647218-7	2008	A significant correlation (r = 0.05) between IL-1 beta and PGE(2) concentrations in saliva from each group was determined.	Prostaglandins E	59-62	interleukin 1 beta	Homo sapiens	45-54
18647218-8	2008	Our findings demonstrated an association between high concentrations of salivary IL-1 beta and PGE(2) and advanced stages of the disease.	Prostaglandins E	95-98	interleukin 1 beta	Homo sapiens	81-90
18639562-6	2008	Clomipramine and imipramine also attenuated the expression of inducible nitric oxide synthase and proinflammatory cytokines such as interleukin-1beta and TNF-alpha at mRNA levels.	Imipramine	17-27	interleukin 1 beta	Homo sapiens	132-149
18769620-10	2008	In HUVECs, atorvastatin dose-dependently decreased IL-1beta-stimulated ENA-78 concentrations (p&lt;0.0001).	Atorvastatin	11-23	interleukin 1 beta	Homo sapiens	51-59
18417374-0	2008	Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.	Nitric Oxide	66-78	interleukin 1 beta	Homo sapiens	40-57
18417374-0	2008	Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.	Dinoprostone	83-99	interleukin 1 beta	Homo sapiens	40-57
18417374-8	2008	RESULTS: HDAC inhibition with TSA or BA resulted in a dose-dependent inhibition of IL-1-induced NO and PGE(2) production.	trichostatin A	30-33	interleukin 1 beta	Homo sapiens	83-87
18417374-8	2008	RESULTS: HDAC inhibition with TSA or BA resulted in a dose-dependent inhibition of IL-1-induced NO and PGE(2) production.	Butyric Acid	37-39	interleukin 1 beta	Homo sapiens	83-87
18417374-8	2008	RESULTS: HDAC inhibition with TSA or BA resulted in a dose-dependent inhibition of IL-1-induced NO and PGE(2) production.	Prostaglandins E	103-106	interleukin 1 beta	Homo sapiens	83-87
18417374-11	2008	TSA and BA also prevented IL-1-induced proteoglycan release from cartilage explants.	trichostatin A	0-3	interleukin 1 beta	Homo sapiens	26-30
18417374-11	2008	TSA and BA also prevented IL-1-induced proteoglycan release from cartilage explants.	Butyric Acid	8-10	interleukin 1 beta	Homo sapiens	26-30
18417374-13	2008	CONCLUSIONS: These data indicate that HDAC inhibitors suppressed IL-1-induced NO and PGE(2) synthesis, iNOS and COX-2 expression, as well as proteoglycan degradation.	Dinoprostone	85-91	interleukin 1 beta	Homo sapiens	65-69
18515365-5	2008	IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not.	Serine	101-104	interleukin 1 beta	Homo sapiens	0-4
18515365-5	2008	IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not.	Serine	110-113	interleukin 1 beta	Homo sapiens	0-4
18515365-5	2008	IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not.	Threonine	130-133	interleukin 1 beta	Homo sapiens	0-4
18515365-5	2008	IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	interleukin 1 beta	Homo sapiens	0-4
18515365-5	2008	IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not.	Wortmannin	222-232	interleukin 1 beta	Homo sapiens	0-4
18515365-5	2008	IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not.	Serine	110-113	interleukin 1 beta	Homo sapiens	0-4
18515365-5	2008	IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not.	Serine	110-113	interleukin 1 beta	Homo sapiens	0-4
18638472-4	2008	Levels of the pro-inflammatory cytokine IL-1beta were reduced by 84% after treatment with SB239063 whereas the cytokines IL-6 and TNF-alpha were not affected.	SB 239063	90-98	interleukin 1 beta	Homo sapiens	40-48
18396374-6	2008	The second experiment examined whether anti-hyperalgesic effects of the COX-inhibitor ibuprofen were associated with decreased tissue levels of the pro-inflammatory cytokines IL-1 beta and IL-6.	Ibuprofen	86-95	interleukin 1 beta	Homo sapiens	175-184
18675261-0	2008	Regulation of interleukin-1beta by the interleukin-1 receptor antagonist in the glutamate-injured spinal cord: endogenous neuroprotection.	Glutamic Acid	80-89	interleukin 1 beta	Homo sapiens	14-31
18675261-1	2008	Elevation of extracellular glutamate contributes to cell death and functional impairments generated by spinal cord injury (SCI), in part through the activation of the neurotoxic cytokine interleukin-1beta (IL-1beta).	Glutamic Acid	27-36	interleukin 1 beta	Homo sapiens	187-204
18675261-1	2008	Elevation of extracellular glutamate contributes to cell death and functional impairments generated by spinal cord injury (SCI), in part through the activation of the neurotoxic cytokine interleukin-1beta (IL-1beta).	Glutamic Acid	27-36	interleukin 1 beta	Homo sapiens	206-214
18675261-2	2008	This study examines the participation of IL-1beta and its regulation by the endogenous interleukin-1 receptor antagonist (IL-1ra) in glutamate toxicity following SCI.	Glutamic Acid	133-142	interleukin 1 beta	Homo sapiens	41-49
18675261-3	2008	Glutamate, glutamatergic agonists and SCI had similar effects on levels of IL-1beta and IL-1ra.	Glutamic Acid	0-9	interleukin 1 beta	Homo sapiens	75-83
18675261-4	2008	Following spinal cord contusion or exposure to elevated glutamate, concentrations of IL-1beta first increased as IL-1ra decreased, and both then changed in the opposite directions.	Glutamic Acid	56-65	interleukin 1 beta	Homo sapiens	85-93
18675261-5	2008	Applying the glutamate agonists NMDA and S-AMPA to the spinal cord caused changes in IL-1beta and IL-1ra levels very similar to those produced by contusion and glutamate.	Glutamic Acid	13-22	interleukin 1 beta	Homo sapiens	85-93
18675261-5	2008	Applying the glutamate agonists NMDA and S-AMPA to the spinal cord caused changes in IL-1beta and IL-1ra levels very similar to those produced by contusion and glutamate.	N-Methylaspartate	32-36	interleukin 1 beta	Homo sapiens	85-93
18675261-6	2008	The glutamate antagonists MK801 and NBQX blocked the glutamate-induced changes in IL-1beta and IL-1ra levels.	Glutamic Acid	4-13	interleukin 1 beta	Homo sapiens	82-90
18675261-6	2008	The glutamate antagonists MK801 and NBQX blocked the glutamate-induced changes in IL-1beta and IL-1ra levels.	Dizocilpine Maleate	26-31	interleukin 1 beta	Homo sapiens	82-90
18675261-6	2008	The glutamate antagonists MK801 and NBQX blocked the glutamate-induced changes in IL-1beta and IL-1ra levels.	2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	36-40	interleukin 1 beta	Homo sapiens	82-90
18675261-6	2008	The glutamate antagonists MK801 and NBQX blocked the glutamate-induced changes in IL-1beta and IL-1ra levels.	Glutamic Acid	53-62	interleukin 1 beta	Homo sapiens	82-90
18675261-10	2008	Our results demonstrate that IL-1beta contributes to glutamate damage following SCI; blocking IL-1beta may usefully counteract glutamate toxicity.	Glutamic Acid	53-62	interleukin 1 beta	Homo sapiens	29-37
18675261-10	2008	Our results demonstrate that IL-1beta contributes to glutamate damage following SCI; blocking IL-1beta may usefully counteract glutamate toxicity.	Glutamic Acid	127-136	interleukin 1 beta	Homo sapiens	94-102
18759268-5	2008	RESULTS: Resveratrol inhibited both spontaneous and IL-1beta-induced PGE(2) production by &gt;20% (P &lt; 0.05) and by 80% (P &lt; 0.001), respectively; similarly, LTB(4) production was reduced by &gt;50% (P &lt; 0.05).	Resveratrol	9-20	interleukin 1 beta	Homo sapiens	52-60
18926057-6	2008	Our data showed that cetirizine (5 and 10 microM) and levocetirizine (2.5, 5, and 10 microM) significantly suppressed GM-CSF secretion from A549 cells stimulated with IL-1beta (p&lt;0.05).	Cetirizine	21-31	interleukin 1 beta	Homo sapiens	167-175
18926057-6	2008	Our data showed that cetirizine (5 and 10 microM) and levocetirizine (2.5, 5, and 10 microM) significantly suppressed GM-CSF secretion from A549 cells stimulated with IL-1beta (p&lt;0.05).	levocetirizine	54-68	interleukin 1 beta	Homo sapiens	167-175
18926057-10	2008	Our results suggest that cetirizine and levocetirizine at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1beta.	Cetirizine	25-35	interleukin 1 beta	Homo sapiens	154-162
18926057-10	2008	Our results suggest that cetirizine and levocetirizine at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1beta.	levocetirizine	40-54	interleukin 1 beta	Homo sapiens	154-162
18586957-2	2008	In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells.	Prostaglandins E	22-25	interleukin 1 beta	Homo sapiens	214-222
18586957-2	2008	In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells.	Colforsin	30-39	interleukin 1 beta	Homo sapiens	214-222
18586957-2	2008	In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells.	Albuterol	59-69	interleukin 1 beta	Homo sapiens	214-222
18586957-2	2008	In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells.	Salmeterol Xinafoate	88-98	interleukin 1 beta	Homo sapiens	214-222
18586957-2	2008	In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells.	Formoterol Fumarate	103-113	interleukin 1 beta	Homo sapiens	214-222
18586957-3	2008	IL-1beta-induced IL-8 release was also repressed by PGE(2) and forskolin, whereas the beta(2)-adrenoceptor agonists were ineffective.	Prostaglandins E	52-55	interleukin 1 beta	Homo sapiens	0-8
18586957-3	2008	IL-1beta-induced IL-8 release was also repressed by PGE(2) and forskolin, whereas the beta(2)-adrenoceptor agonists were ineffective.	Colforsin	63-72	interleukin 1 beta	Homo sapiens	0-8
18586957-8	2008	This finding is consistent with the observation that IL-1beta-induced expression of IL-6, a known NF-kappaB-dependent gene in ASM, was also unaffected by beta(2)-adrenoceptor agonists, forskolin, PGE(2), 8-bromo-cAMP, or rolipram.	8-Bromo Cyclic Adenosine Monophosphate	204-216	interleukin 1 beta	Homo sapiens	53-61
18586957-8	2008	This finding is consistent with the observation that IL-1beta-induced expression of IL-6, a known NF-kappaB-dependent gene in ASM, was also unaffected by beta(2)-adrenoceptor agonists, forskolin, PGE(2), 8-bromo-cAMP, or rolipram.	Rolipram	221-229	interleukin 1 beta	Homo sapiens	53-61
18586957-9	2008	Collectively, these results indicate that repression of IL-1beta-induced ICAM-1 expression and GM-CSF release by cAMP-elevating agents, including beta(2)-adrenoceptor agonists, may not occur through a generic effect on NF-kappaB.	Cyclic AMP	113-117	interleukin 1 beta	Homo sapiens	56-64
18781015-5	2008	The 11-FUT modified FET sensor with an AC voltage at 1 MHz superimposed onto the reference electrode detected the AChE-catalyzed product corresponding to a serum concentration of interleukin 1beta from 10 to 5000 pg/mL.	11-fut	4-10	interleukin 1 beta	Homo sapiens	179-196
18390475-3	2008	Because TNF-alpha and IL-1beta induce Hyals in other cells, we tested their effects on Hyals expression and activity.	hyals	38-43	interleukin 1 beta	Homo sapiens	22-30
18756431-9	2008	In patients at risk of preterm labor, high-dose 17P simultaneously inhibits both cervical proinflammatory IL-1beta secretion and the progressive shortening of the cervix.	17 alpha-Hydroxyprogesterone Caproate	48-51	interleukin 1 beta	Homo sapiens	106-114
18759268-5	2008	RESULTS: Resveratrol inhibited both spontaneous and IL-1beta-induced PGE(2) production by &gt;20% (P &lt; 0.05) and by 80% (P &lt; 0.001), respectively; similarly, LTB(4) production was reduced by &gt;50% (P &lt; 0.05).	Prostaglandins E	69-72	interleukin 1 beta	Homo sapiens	52-60
18759268-8	2008	Pretreatment of OA chondrocytes with resveratrol blocked mitochondrial membrane depolarization, loss of mitochondrial biomass, and IL-1beta-induced ATP depletion.	Resveratrol	37-48	interleukin 1 beta	Homo sapiens	131-139
18759268-8	2008	Pretreatment of OA chondrocytes with resveratrol blocked mitochondrial membrane depolarization, loss of mitochondrial biomass, and IL-1beta-induced ATP depletion.	Adenosine Triphosphate	148-151	interleukin 1 beta	Homo sapiens	131-139
18759268-9	2008	Similarly, IL-1beta-mediated induction of the apoptotic markers cytochrome c and annexin V was also inhibited by resveratrol.	Resveratrol	113-124	interleukin 1 beta	Homo sapiens	11-19
18759268-11	2008	CONCLUSION: Resveratrol protects against IL-1beta-induced catabolic effects and prevents chondrocyte apoptosis via its inhibition of mitochondrial membrane depolarization and ATP depletion.	Resveratrol	12-23	interleukin 1 beta	Homo sapiens	41-49
18377686-8	2008	Ellagic acid, genistein and epigallocatechin gallate reduced (4- to 8-fold) IL-1beta-induced IL-8 secretion, while resveratrol promoted (1.7-fold) the secretion.	Ellagic Acid	0-12	interleukin 1 beta	Homo sapiens	76-84
18377686-8	2008	Ellagic acid, genistein and epigallocatechin gallate reduced (4- to 8-fold) IL-1beta-induced IL-8 secretion, while resveratrol promoted (1.7-fold) the secretion.	Genistein	14-23	interleukin 1 beta	Homo sapiens	76-84
18377686-8	2008	Ellagic acid, genistein and epigallocatechin gallate reduced (4- to 8-fold) IL-1beta-induced IL-8 secretion, while resveratrol promoted (1.7-fold) the secretion.	epigallocatechin gallate	28-52	interleukin 1 beta	Homo sapiens	76-84
18780953-4	2008	Secretion of IL-1beta and TNF-alpha in the presence of lipopolysaccaharide was evaluated in supernatants of monocyte culture.DBAs significantly caused reduction of cytokine production by human monocytes after 36 and 72 hours.	lipopolysaccaharide	55-74	interleukin 1 beta	Homo sapiens	13-21
18550688-6	2008	In intact interleukin-1beta-treated A549 cells, licofelone potently (IC(50) &lt; 1 microM) blocked formation of PGE(2) in response to calcimycin (A23187) plus exogenous arachidonic acid, but the concomitant generation of 6-keto PGF(1alpha), used as a biomarker for COX-2 activity, was not inhibited.	licofelone	48-58	interleukin 1 beta	Homo sapiens	10-27
18613793-8	2008	In addition, compared with the CP group, in the CTU group the balance between proinflammatory mediators (such as tumor necrosis factor-alpha, interleukin [IL]-1beta, IL-6, and IL-8) and anti-inflammatory cytokines (including IL-4 and IL-10) was better modulated, and the cumulative survival rate of the CTU group exceeded that of the CP group by 17.8% at day 28, 25.9% at day 60, and 27.4% at day 90.	3,9-Bis(2-cyanoethyl)-2,4,8,10-tetraoxaspiro[5.5]undecane	48-51	interleukin 1 beta	Homo sapiens	155-164
18771379-7	2008	RESULTS: The secretion of IL-1beta and -8 and TNF-alpha by macrophages decreased significantly (P &lt;0.05) when they were pretreated with 2 microM doxycycline, whereas a concentration of 10 microM was required to significantly reduce IL-6 secretion.	Doxycycline	148-159	interleukin 1 beta	Homo sapiens	26-41
18053089-3	2008	Inhibition of transcription factors binding (decoy oligonucleotides or mithramycin) abolished IL-1beta effect.	decoy oligonucleotides	45-67	interleukin 1 beta	Homo sapiens	94-102
18053089-3	2008	Inhibition of transcription factors binding (decoy oligonucleotides or mithramycin) abolished IL-1beta effect.	Plicamycin	71-82	interleukin 1 beta	Homo sapiens	94-102
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	polyinosinic	28-40	interleukin 1 beta	Homo sapiens	130-142
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly C	41-59	interleukin 1 beta	Homo sapiens	130-142
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly I-C	61-69	interleukin 1 beta	Homo sapiens	130-142
18725521-6	2008	Surprisingly, poly(I:C)- and LPS-induced pro-IL-1beta processing still occurred in caspase-1-deficient cells.	Poly I-C	14-23	interleukin 1 beta	Homo sapiens	41-53
18550688-6	2008	In intact interleukin-1beta-treated A549 cells, licofelone potently (IC(50) &lt; 1 microM) blocked formation of PGE(2) in response to calcimycin (A23187) plus exogenous arachidonic acid, but the concomitant generation of 6-keto PGF(1alpha), used as a biomarker for COX-2 activity, was not inhibited.	Calcimycin	134-144	interleukin 1 beta	Homo sapiens	10-27
18790761-6	2008	FuEP2/Ex2 neutralized PGE2-induced cyclic AMP production, cyclic AMP-responsive element binding protein phosphorylation, and subsequent induction of cyclooxygenase-2, interleukin (IL)-1beta, and IL-6 mRNAs.	Dinoprostone	22-26	interleukin 1 beta	Homo sapiens	167-189
18699740-5	2008	Both reporters were binding p50 protein, which protected oligonucleotide duplex from degradation in the presence of exonuclease.The incubation of 800CW-Cy reporter in the presence of control or IL-1beta treated human endothelial cells showed the uptake of the reporter in the cytoplasm and the nucleus.	Oligonucleotides	57-72	interleukin 1 beta	Homo sapiens	194-202
17467122-7	2008	Indeed, IL-1 beta suppressed the activation of the respective scaffolding proteins IRS-1 and Shc; this effect might involve ceramide generation.	Ceramides	124-132	interleukin 1 beta	Homo sapiens	8-17
17467122-9	2008	These results suggest that IL-1 beta places neurons at risk by interfering with BDNF signaling involving a ceramide-associated mechanism.	Ceramides	107-115	interleukin 1 beta	Homo sapiens	27-36
18699740-5	2008	Both reporters were binding p50 protein, which protected oligonucleotide duplex from degradation in the presence of exonuclease.The incubation of 800CW-Cy reporter in the presence of control or IL-1beta treated human endothelial cells showed the uptake of the reporter in the cytoplasm and the nucleus.	800cw-cy	146-154	interleukin 1 beta	Homo sapiens	194-202
18768046-11	2008	Lung tissue homogenate in the methylprednisolone group had lower levels of TNF-alpha (P &lt; 0.05), IL-1beta (P &lt; 0.05), and IL-8 (P &lt; 0.05) in both the collapsed and the ventilated lungs.	Methylprednisolone	30-48	interleukin 1 beta	Homo sapiens	100-108
18710562-11	2008	15-HETE (15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid) a potent lipoperoxidation derivative generated by HZ from arachidonic acid via haem-catalysis was identified as one mediator possibly responsible for increase of both IL-1beta production and MMP-9 activity.	Arachidonic Acid	116-132	interleukin 1 beta	Homo sapiens	225-233
18779659-3	2008	The stimulation of lymphoid cells with TNF-alpha, IL-1beta, and LPS resulted in significant ROS production and NF-kappaB activation.	Reactive Oxygen Species	92-95	interleukin 1 beta	Homo sapiens	50-58
18541144-3	2008	Nobiletin (16-64muM) interfered with the interleukin (IL)-1beta-mediated ADAMTS-4 and -5 mRNA expression in cultured human synovial fibroblasts.	nobiletin	0-9	interleukin 1 beta	Homo sapiens	41-63
18710562-11	2008	15-HETE (15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid) a potent lipoperoxidation derivative generated by HZ from arachidonic acid via haem-catalysis was identified as one mediator possibly responsible for increase of both IL-1beta production and MMP-9 activity.	15-Hete	0-7	interleukin 1 beta	Homo sapiens	225-233
18617548-9	2008	TCDD up-regulated the expression of IL-1beta, IL-6 and IL-8 through binding to AhR, and this effect was transmitted via the NF-kappaB and ERK signalling cascades.	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Homo sapiens	36-44
18710562-11	2008	15-HETE (15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid) a potent lipoperoxidation derivative generated by HZ from arachidonic acid via haem-catalysis was identified as one mediator possibly responsible for increase of both IL-1beta production and MMP-9 activity.	Heme	137-141	interleukin 1 beta	Homo sapiens	225-233
18710562-12	2008	CONCLUSION: Results indicate that specific lipoperoxide derivatives generated by HZ may play a role in modulating production of IL-1beta and MMP-9 expression and activity in HZ/trophozoite-fed human monocytes.	Lipid Peroxides	43-55	interleukin 1 beta	Homo sapiens	128-136
18710562-11	2008	15-HETE (15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid) a potent lipoperoxidation derivative generated by HZ from arachidonic acid via haem-catalysis was identified as one mediator possibly responsible for increase of both IL-1beta production and MMP-9 activity.	(s,r)-hydroxy-6,8,11,13-eicosatetraenoic acid	11-56	interleukin 1 beta	Homo sapiens	225-233
18541537-4	2008	Adenovirus-mediated delivery of the NFAT inhibitor, VIVIT, suppressed the IL-1beta-dependent induction of several inflammatory mediators and/or markers of astrocyte activation, including tumor necrosis factor alpha, granulocyte/macrophage colony-stimulating factor, and vimentin.	NFAT Inhibitor	52-57	interleukin 1 beta	Homo sapiens	74-82
18519030-0	2008	Inhibition of NMDA-induced outward currents by interleukin-1beta in hippocampal neurons.	N-Methylaspartate	14-18	interleukin 1 beta	Homo sapiens	47-64
18519030-2	2008	The present study attempted to elucidate the effect of IL-1beta on the NMDA-induced outward currents in mechanically dissociated hippocampal neurons using a perforated patch recording technique.	N-Methylaspartate	71-75	interleukin 1 beta	Homo sapiens	55-63
18519030-3	2008	IL-1beta (30-100 ng/ml) inhibited the mean amplitude of the NMDA-induced outward currents that were mediated by charybdotoxin (ChTX)-sensitive Ca(2+)-activated K(+) (K(Ca)) channels.	N-Methylaspartate	60-64	interleukin 1 beta	Homo sapiens	0-8
18519030-3	2008	IL-1beta (30-100 ng/ml) inhibited the mean amplitude of the NMDA-induced outward currents that were mediated by charybdotoxin (ChTX)-sensitive Ca(2+)-activated K(+) (K(Ca)) channels.	Charybdotoxin	112-125	interleukin 1 beta	Homo sapiens	0-8
18519030-3	2008	IL-1beta (30-100 ng/ml) inhibited the mean amplitude of the NMDA-induced outward currents that were mediated by charybdotoxin (ChTX)-sensitive Ca(2+)-activated K(+) (K(Ca)) channels.	Charybdotoxin	127-131	interleukin 1 beta	Homo sapiens	0-8
18519030-4	2008	IL-1beta (100 ng/ml) also significantly increased the mean ratio of the NMDA-induced inward current amplitudes measured at the end to the beginning of a 20-s application of NMDA.	N-Methylaspartate	72-76	interleukin 1 beta	Homo sapiens	0-8
18519030-4	2008	IL-1beta (100 ng/ml) also significantly increased the mean ratio of the NMDA-induced inward current amplitudes measured at the end to the beginning of a 20-s application of NMDA.	N-Methylaspartate	173-177	interleukin 1 beta	Homo sapiens	0-8
18541537-7	2008	In the presence of astrocytes and neurons, 48-h delivery of IL-1beta was associated with several excitotoxic effects, including NMDA receptor-dependent neuronal death, elevated extracellular glutamate, and hyperexcitable synaptic activity.	Glutamic Acid	191-200	interleukin 1 beta	Homo sapiens	60-68
18573490-0	2008	Novel iminobenzoxathiolone compound inhibits nuclear factor-kappaB activation targeting inhibitory kappaB kinase beta and down-regulating interleukin-1beta expression in lipopolysaccharide-activated macrophages.	iminobenzoxathiolone	6-26	interleukin 1 beta	Homo sapiens	138-155
18624356-0	2008	The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity.	Aluminum Hydroxide	39-58	interleukin 1 beta	Homo sapiens	68-76
18641357-6	2008	We also showed that extracellular ATP induced Ca(2+) transients and increased IL-1beta secretion via P2X receptors.	Adenosine Triphosphate	34-37	interleukin 1 beta	Homo sapiens	78-86
18612139-9	2008	KdPT, a derivative of KPV corresponding to amino acids 193-195 of IL-1beta, is also emerging as a tripeptide with antiinflammatory effects.	tripeptide K-26	98-108	interleukin 1 beta	Homo sapiens	66-74
18458045-5	2008	Coincubation with 13-cis-RA and interleukin-1beta resulted in a synergic increase in the release of PGI(2).	Prostaglandins I	100-103	interleukin 1 beta	Homo sapiens	32-49
18729741-4	2008	Cycloheximide treatment indicated that the augmenting effect of CSC on IL-1alpha, IL-1beta and IL-8, but not IL-6 and CYP1A1, mRNA expression requires de novo protein synthesis.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	82-90
18624356-8	2008	These results indicate that alum induces IL-1beta via the Nlrp3 inflammasome but this activity is dispensable for alum-mediated adjuvant activity.	Aluminum Hydroxide	28-32	interleukin 1 beta	Homo sapiens	41-49
18155512-0	2008	Epigallocatechin-3-gallate inhibits interleukin-1beta-induced MUC5AC gene expression and MUC5AC secretion in normal human nasal epithelial cells.	epigallocatechin gallate	0-26	interleukin 1 beta	Homo sapiens	36-53
18155512-3	2008	In this study, we examined the effect of (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on IL-1beta-induced MUC5AC gene expression and secretion in NHNE cells.	epigallocatechin gallate	41-71	interleukin 1 beta	Homo sapiens	107-115
18155512-3	2008	In this study, we examined the effect of (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on IL-1beta-induced MUC5AC gene expression and secretion in NHNE cells.	epigallocatechin gallate	73-77	interleukin 1 beta	Homo sapiens	107-115
18155512-3	2008	In this study, we examined the effect of (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on IL-1beta-induced MUC5AC gene expression and secretion in NHNE cells.	Polyphenols	92-102	interleukin 1 beta	Homo sapiens	107-115
18155512-7	2008	EGCG markedly suppressed IL-1beta-induced MUC5AC gene expression and MUC5AC secretion via suppression of the phosphorylation of ERK MAP kinase, MSK1, and transcription factor, cAMP response element-binding protein.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	25-33
18155512-7	2008	EGCG markedly suppressed IL-1beta-induced MUC5AC gene expression and MUC5AC secretion via suppression of the phosphorylation of ERK MAP kinase, MSK1, and transcription factor, cAMP response element-binding protein.	Cyclic AMP	176-180	interleukin 1 beta	Homo sapiens	25-33
18155512-9	2008	Our data suggest that EGCG may be an effective inhibitor of IL-1beta-induced mucus hypersecretion.	epigallocatechin gallate	22-26	interleukin 1 beta	Homo sapiens	60-68
18622277-9	2008	Tumor necrosis factor-alpha, interleukin-1beta, monocyte chemotactic protein-1, and macrophage inflammatory protein-1beta production from the impure sirolimus group significantly decreased (P&lt;0.05).	Sirolimus	149-158	interleukin 1 beta	Homo sapiens	29-46
18340449-6	2008	Among MAPK pathways involved in the transcriptional regulation of AP-1, phosphorylation of JNK and ERK was found to increase with the presence of GLN under IL-1beta treatment, while that for p38 decreased.	Glucosamine	146-149	interleukin 1 beta	Homo sapiens	156-164
18340449-7	2008	It was also found that GLN alone, but also synergistically with IL-1beta, was able to activate the Akt pathway.	Glucosamine	23-26	interleukin 1 beta	Homo sapiens	64-72
18435907-5	2008	Interestingly, the effects of tranilast on LPS-induced PGE(2), NO, TNF-alpha, and IL-1beta production were partially reversed by the HO-1 inhibitor tin protoporphyrin, suggesting that tranilast-induced HO-1 expression is at least partly responsible for the resulting anti-inflammatory effects of the drug.	protoporphyrin IX	152-166	interleukin 1 beta	Homo sapiens	82-90
18498042-4	2008	We found that TET decreased the release of NO, TNF-alpha, IL-6 and IL-1beta in LPS-activated astrocytes.	tet	14-17	interleukin 1 beta	Homo sapiens	67-75
18340449-1	2008	The purpose of the present study was to elucidate the possible signal transduction pathway involved in the underlying mechanism of glucosamine (GLN)"s influence on the gene expression of matrix metalloproteinases (MMPs) in chondrocytes stimulated with IL-1beta.	Glucosamine	131-142	interleukin 1 beta	Homo sapiens	252-260
18340449-1	2008	The purpose of the present study was to elucidate the possible signal transduction pathway involved in the underlying mechanism of glucosamine (GLN)"s influence on the gene expression of matrix metalloproteinases (MMPs) in chondrocytes stimulated with IL-1beta.	Glucosamine	144-147	interleukin 1 beta	Homo sapiens	252-260
18340449-3	2008	GLN inhibited the expression and the synthesis of MMP-3 induced by IL-1beta, and that inhibition was mediated at the level of transcription involving both the NF-kappaB and AP-1 transcription factors.	Glucosamine	0-3	interleukin 1 beta	Homo sapiens	67-75
18340449-5	2008	A slightly synergistic effect on the activation of AP-1 induced by IL-1beta was shown in the presence of GLN.	Glucosamine	105-108	interleukin 1 beta	Homo sapiens	67-75
18606639-7	2008	DXS also inhibits the functional maturation of DC as demonstrated by reduced T cell proliferation, and strongly impairs secretion of the proinflammatory mediators IL-1beta, IL-6, IL-12p70, and TNF-alpha.	Dextran Sulfate	0-3	interleukin 1 beta	Homo sapiens	163-171
18456659-8	2008	TAB4 mutated at Phe-Pro dominantly interfered with IL-1beta activation of NF-kappaB involving IKK-dependent but not p38 MAPK-dependent signaling.	Phenylalanine	16-19	interleukin 1 beta	Homo sapiens	51-59
18474597-7	2008	Here we examined the effects of H(2)O(2) on NF-kappaB dynamics and pro-inflammatory activation in cultured cells co-stimulated with TNFalpha or IL-1beta.	Hydrogen Peroxide	32-40	interleukin 1 beta	Homo sapiens	144-152
18467203-14	2008	The enhanced kinin receptor expression induced by the pro-inflammatory cytokines IL-1beta and TNF-alpha might be one important mechanism involved in the synergistic enhancement of prostaglandin formation caused by co-treatment with kinins and one of the two cytokines.	Prostaglandins	180-193	interleukin 1 beta	Homo sapiens	81-89
18576346-8	2008	IL-4 expressed in the presence of IL-1beta and TNFalpha down-regulated a series of inflammation mediators, prostaglandins, and matrix metalloproteinases.	Prostaglandins	107-121	interleukin 1 beta	Homo sapiens	34-42
18420487-7	2008	In marked contrast, exposure of HRECs to proinflammatory cytokines IL-1beta or TNF-alpha increased glucose consumption, mitochondrial superoxide production, ERK and JNK phosphorylation, tyrosine phosphorylation, NF-kappaB activation, and caspase activation.	Tyrosine	186-194	interleukin 1 beta	Homo sapiens	67-75
18420487-7	2008	In marked contrast, exposure of HRECs to proinflammatory cytokines IL-1beta or TNF-alpha increased glucose consumption, mitochondrial superoxide production, ERK and JNK phosphorylation, tyrosine phosphorylation, NF-kappaB activation, and caspase activation.	Glucose	99-106	interleukin 1 beta	Homo sapiens	67-75
18420487-7	2008	In marked contrast, exposure of HRECs to proinflammatory cytokines IL-1beta or TNF-alpha increased glucose consumption, mitochondrial superoxide production, ERK and JNK phosphorylation, tyrosine phosphorylation, NF-kappaB activation, and caspase activation.	Superoxides	134-144	interleukin 1 beta	Homo sapiens	67-75
18535404-7	2008	In most instances, peaks in serum levels occurred following initial histological changes, Although following MTX administration, serum IL-1beta peaked before histological changes and following 5-FU administration, serum NFkappaB, TNF, IL-1beta and IL-6 all peaked before histological evidence of tissue damage.	Fluorouracil	193-197	interleukin 1 beta	Homo sapiens	135-143
18506884-6	2008	The mutually antagonistic relationship between IFN-gamma and PGE(2) extends to downstream cytokine and chemokine release; PGE(2) counters the effects of IFN-gamma, on the release of IP-10, IL-8, TNF-alpha and IL-1beta.	Prostaglandins E	122-125	interleukin 1 beta	Homo sapiens	209-217
18638431-3	2008	At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3) inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils.	Uric Acid	44-60	interleukin 1 beta	Homo sapiens	162-170
18492658-6	2008	Transfection with AxIkappaBalphaM or addition of a p38 inhibitor (SB203580) significantly decreased the dsRNA-mediated production of TNF-alpha, IL-1beta and MIP-1alpha, but not of IFN-beta, IL-15, MIP-1beta, RANTES or LARC.	axikappabalpham	18-33	interleukin 1 beta	Homo sapiens	144-152
18492658-6	2008	Transfection with AxIkappaBalphaM or addition of a p38 inhibitor (SB203580) significantly decreased the dsRNA-mediated production of TNF-alpha, IL-1beta and MIP-1alpha, but not of IFN-beta, IL-15, MIP-1beta, RANTES or LARC.	SB 203580	66-74	interleukin 1 beta	Homo sapiens	144-152
18384650-6	2008	Potentiation of AMPA toxicity was prevented when IL-1beta production or its receptor signaling were blocked by an inhibitor of interleukin-converting-enzyme or IL-1 receptor antagonist during application of LPS + ATP.	Adenosine Triphosphate	213-216	interleukin 1 beta	Homo sapiens	49-57
18830893-5	2008	PAH induced significant secretion of IL-1beta, IL-8, and IL-12 after 24 or 48 hr of treatment, an effect reinforced by LPS stimulation; no effect on IL-10 secretion was noted.	Polycyclic Aromatic Hydrocarbons	0-3	interleukin 1 beta	Homo sapiens	37-45
18830893-9	2008	For example, PAH coating on ufCB amplified the inhibitory effect of ufCB against IL-1beta secretion but did not modify IL-8 formation.	Polycyclic Aromatic Hydrocarbons	13-16	interleukin 1 beta	Homo sapiens	81-89
18419766-4	2008	Here we show that stimulation of astrocytes with IL-1beta, lipopolysaccharide or ethanol (10 and 50 mM), triggers the translocation of IL-1RI and/or TLR4 into lipid rafts caveolae-enriched fractions, promoting the recruitment of signalling molecules (phospho-IL-1R-associated kinase and phospho-extracellular regulated-kinase) into these microdomains.	Ethanol	81-88	interleukin 1 beta	Homo sapiens	49-57
18515093-6	2008	LCA pretreatment inhibited the IL-1beta-induced IkappaBalpha degradation and decreased the NF-kappaB p65 phosphorylation.	Lithocholic Acid	0-3	interleukin 1 beta	Homo sapiens	31-39
18515093-8	2008	LCA significantly decreased IL-8 secretion induced by IL-1beta.	Lithocholic Acid	0-3	interleukin 1 beta	Homo sapiens	54-62
18515093-10	2008	Thus, LCA recapitulated the effects of 1,25(OH)(2)D(3) on IL-1beta stimulated cells.	Lithocholic Acid	6-9	interleukin 1 beta	Homo sapiens	58-66
19079193-7	2008	Estradiol also reversed the stimulatory effects of IL-1beta on mRNA expression of TNF-alpha, IL-8, and NF-kB by 85, 95, and 70%, respectively.	Estradiol	0-9	interleukin 1 beta	Homo sapiens	51-59
18471882-4	2008	Here we show that in contrast with PI3Kalpha, beta and gamma, PI3Kdelta accounts for most of the PI3K-dependent signaling ruling the production of IL-1beta, IL-6, TNF and sIL-1Ra in monocytes activated by cellular contact with stimulated T cells (mimicked by CHAPS-solubilized membranes of stimulated T cells, CE sHUT) and lipopolysaccharides (LPS); the latter stimuli being relevant to chronic/sterile and acute/infectious inflammation, respectively.	3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate	259-264	interleukin 1 beta	Homo sapiens	147-155
18767394-1	2008	The beta-endorphin 10(-7-)-10(-11) M in LPS (lypopolisaccharide) presence and in spontaneous cultures promoted the IL-1beta production in mixed leukocyte fraction.	lypopolisaccharide	45-63	interleukin 1 beta	Homo sapiens	115-123
18360309-4	2008	IL-1beta, IL-6 mRNA were closely correlated to PDGF-B mRNA and myeloperoxidase, but inversely to IGF-I mRNA, Pao2/FiO2 and dynamic lung compliance at 6 h. These results indicate that the association of lower PEEP and iNO may be more protective than surfactant on preventing lung injury and facilitating reparation by affecting the expression of proinflammatory cytokines and GFs.	fio2	114-118	interleukin 1 beta	Homo sapiens	0-8
18762411-2	2008	We therefore investigated the anti-inflammatory effects of eicosapentaenoic acid (EPA) on interleukin (IL)-1beta-stimulated C6 glioma cells.	Eicosapentaenoic Acid	82-85	interleukin 1 beta	Homo sapiens	90-112
18762411-3	2008	In the present study, EPA inhibited pro-inflammatory cytokine IL-6 production, a characteristic of certain neurodegenerative disorders, in IL-1beta-stimulated C6 glioma cells in dose-dependent fashion.	Eicosapentaenoic Acid	22-25	interleukin 1 beta	Homo sapiens	139-147
18762411-5	2008	In addition, peroxisome proliferator-activated receptor (PPAR) gamma antagonists abolished the inhibitory effect of EPA on IL-1beta-induced IL-6 production, whereas PPARalpha antagonist did not block the inhibitory effect of EPA.	Eicosapentaenoic Acid	116-119	interleukin 1 beta	Homo sapiens	123-131
18571585-11	2008	U937-conditioned medium and interleukin-1beta stimulated expression of cyclooxygenase-2 and prostaglandin E(2) production in pancreatic cancer cells, which was mediated by activation of the ERK1/2 pathway.	Dinoprostone	92-110	interleukin 1 beta	Homo sapiens	28-45
18571585-13	2008	CONCLUSIONS: Mononuclear cells protect pancreatic cancer cells from drug-induced apoptosis in vitro by interleukin-1beta-mediated expression of cyclooxygenase-2 and production of prostaglandins.	Prostaglandins	179-193	interleukin 1 beta	Homo sapiens	103-120
18375789-5	2008	ERB-041 [7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-1,3-benzoxazol-5-ol], an ERbeta agonist, was profiled on cytokine release from interleukin-1beta-stimulated human airway smooth muscle (HASM) cells and in the rodent asthma model.	ERB 041	9-67	interleukin 1 beta	Homo sapiens	127-144
18762411-0	2008	Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma.	Eicosapentaenoic Acid	0-21	interleukin 1 beta	Homo sapiens	59-76
18762411-2	2008	We therefore investigated the anti-inflammatory effects of eicosapentaenoic acid (EPA) on interleukin (IL)-1beta-stimulated C6 glioma cells.	Eicosapentaenoic Acid	59-80	interleukin 1 beta	Homo sapiens	90-112
18767394-2	2008	LPS-induced IL-8 production in leukocyte fraction was inhibited by beta-endorphin 10(-7), 10(-11) M. The enchasing effect of beta-endorphin on IL-1beta production was not blocked by naloxone and naltrindole.	lps	0-3	interleukin 1 beta	Homo sapiens	143-151
18587266-0	2008	Effect of sildenafil citrate on interleukin-1beta-induced nitric oxide synthesis and iNOS expression in SW982 cells.	Sildenafil Citrate	10-28	interleukin 1 beta	Homo sapiens	32-49
18935911-3	2008	In this study, we found that menthone can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as nuclear factor kappaB (NF-kappaB) activity induced by LPS and other inflammatory agents, including 12-O-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid, and ceramide.	menthone	29-37	interleukin 1 beta	Homo sapiens	115-132
18935911-3	2008	In this study, we found that menthone can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as nuclear factor kappaB (NF-kappaB) activity induced by LPS and other inflammatory agents, including 12-O-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid, and ceramide.	menthone	29-37	interleukin 1 beta	Homo sapiens	134-142
18587266-0	2008	Effect of sildenafil citrate on interleukin-1beta-induced nitric oxide synthesis and iNOS expression in SW982 cells.	Nitric Oxide	58-70	interleukin 1 beta	Homo sapiens	32-49
18587266-1	2008	The purpose of this study was to identify the effect of sildenafil citrate on IL-1beta-induced nitric oxide (NO) synthesis and iNOS expression in human synovial sarcoma SW982 cells.	Sildenafil Citrate	56-74	interleukin 1 beta	Homo sapiens	78-86
18587266-1	2008	The purpose of this study was to identify the effect of sildenafil citrate on IL-1beta-induced nitric oxide (NO) synthesis and iNOS expression in human synovial sarcoma SW982 cells.	Nitric Oxide	95-107	interleukin 1 beta	Homo sapiens	78-86
18587266-4	2008	The IL-1beta-induced NO synthesis was inhibited by guanylate cyclase (GC) inhibitor, LY83583.	6-anilino-5,8-quinolinedione	85-92	interleukin 1 beta	Homo sapiens	4-12
18587266-7	2008	When SW982 cells were pretreated with sildenafil citrate (Viagra), a PDE5 specific inhibitor, sildenafil citrate significantly inhibited IL-1beta-induced NO synthesis and iNOS expressions.	Sildenafil Citrate	38-56	interleukin 1 beta	Homo sapiens	137-145
18587266-7	2008	When SW982 cells were pretreated with sildenafil citrate (Viagra), a PDE5 specific inhibitor, sildenafil citrate significantly inhibited IL-1beta-induced NO synthesis and iNOS expressions.	Sildenafil Citrate	58-64	interleukin 1 beta	Homo sapiens	137-145
18587266-7	2008	When SW982 cells were pretreated with sildenafil citrate (Viagra), a PDE5 specific inhibitor, sildenafil citrate significantly inhibited IL-1beta-induced NO synthesis and iNOS expressions.	Sildenafil Citrate	94-112	interleukin 1 beta	Homo sapiens	137-145
18587266-8	2008	From this result, we noticed that PDE5 activity is required for IL-1?-induced NO synthesis and iNOS expressions in human synovial sarcoma cells, and sildenafil citrate may be able to suppress an inflammatory reaction of synovium through inhibition of NO synthesis and iNOS expression by cytokines.	Sildenafil Citrate	149-167	interleukin 1 beta	Homo sapiens	64-68
18523012-5	2008	Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid are all competent to induce maturation and secretion of IL-1beta and IL-18 through a process that involves as a first event the extracellular release of endogenous ATP.	Adenosine Triphosphate	323-326	interleukin 1 beta	Homo sapiens	215-223
18549505-13	2008	Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM).	Curcumin	0-8	interleukin 1 beta	Homo sapiens	108-116
18549505-13	2008	Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM).	Resveratrol	13-24	interleukin 1 beta	Homo sapiens	108-116
18523309-4	2008	In this study we demonstrate that ATP-induced cellular oxidation is critical for caspase-1 activation and subsequent IL-1beta processing.	Adenosine Triphosphate	34-37	interleukin 1 beta	Homo sapiens	117-125
18523309-6	2008	IL-1beta cleavage is blocked under conditions where superoxide anion formation is blocked or monocytes are treated with antioxidants or a peroxynitrite scavenger.	Superoxides	52-68	interleukin 1 beta	Homo sapiens	0-8
18523309-6	2008	IL-1beta cleavage is blocked under conditions where superoxide anion formation is blocked or monocytes are treated with antioxidants or a peroxynitrite scavenger.	Peroxynitrous Acid	138-151	interleukin 1 beta	Homo sapiens	0-8
18523309-7	2008	Nigericin, a K(+)/H(+) antiporter, also increases NADPH oxidase activity, leading to IL-1beta and caspase-1 processing that is blocked by a peroxynitrite scavenger or inhibition of NADPH oxidase.	Nigericin	0-9	interleukin 1 beta	Homo sapiens	85-93
18523309-7	2008	Nigericin, a K(+)/H(+) antiporter, also increases NADPH oxidase activity, leading to IL-1beta and caspase-1 processing that is blocked by a peroxynitrite scavenger or inhibition of NADPH oxidase.	Peroxynitrous Acid	140-153	interleukin 1 beta	Homo sapiens	85-93
18448096-5	2008	Aurothiomalate inhibited IL-1beta-induced COX-2 protein expression and PGE(2) production in chondrocytes in a dose-dependent manner.	Gold Sodium Thiomalate	0-14	interleukin 1 beta	Homo sapiens	25-33
18448096-5	2008	Aurothiomalate inhibited IL-1beta-induced COX-2 protein expression and PGE(2) production in chondrocytes in a dose-dependent manner.	Dinoprostone	71-77	interleukin 1 beta	Homo sapiens	25-33
18523012-0	2008	ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	91-99
18523012-5	2008	Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid are all competent to induce maturation and secretion of IL-1beta and IL-18 through a process that involves as a first event the extracellular release of endogenous ATP.	Uric Acid	149-158	interleukin 1 beta	Homo sapiens	215-223
18523012-11	2008	Thus, stimuli acting on different pathogen-sensing receptors converge on a common pathway where ATP externalization is the first step in the cascade of events leading to inflammasome activation and IL-1beta and IL-18 secretion.	Adenosine Triphosphate	96-99	interleukin 1 beta	Homo sapiens	198-206
18276934-3	2008	Excess decidual cell-expressed matrix metalloproteinases (MMPs) 2 and 9, in response to preeclampsia-related interleukin 1 beta (IL1B) and tumor necrosis factor alpha (TNF), may inappropriately degrade these basement membrane proteins and impede EVT invasion.	EVT	246-249	interleukin 1 beta	Homo sapiens	109-127
18495175-0	2008	Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes.	pregna-4,17-diene-3,16-dione	0-13	interleukin 1 beta	Homo sapiens	21-29
18495175-3	2008	Therefore, in this study, the effect of guggulsterone on interleukin (IL)-1beta-induced inflammatory responses in the FLS of rheumatic patients was investigated.	pregna-4,17-diene-3,16-dione	40-53	interleukin 1 beta	Homo sapiens	57-79
18495175-6	2008	However, pre-incubation with guggulsterone completely inhibited the ability of IL-1beta to induce the production of chemokines and to activate MMPs.	pregna-4,17-diene-3,16-dione	29-42	interleukin 1 beta	Homo sapiens	79-87
18495175-7	2008	Although the NF-kappaB binding activity and nuclear p50 and p65 subunit levels, as well as IkappaBalpha degradation in the cytoplasm was greater in cells stimulated with IL-1beta than in unstimulated cells, treatment with guggulsterone abolished all of these increases.	pregna-4,17-diene-3,16-dione	222-235	interleukin 1 beta	Homo sapiens	170-178
18192036-0	2008	Imidaprilat inhibits matrix metalloproteinase-2 activity in human cardiac fibroblasts induced by interleukin-1beta via NO-dependent pathway.	imidaprilat	0-11	interleukin 1 beta	Homo sapiens	97-114
18192036-2	2008	The purpose of this study was to determine the ability and possible signal pathway involved of imidaprilat, an ACE inhibitor, to modulate MMP-2 and TIMP-2 in human cardiac fibroblasts in the presence of interleukin (IL)-1beta.	imidaprilat	95-106	interleukin 1 beta	Homo sapiens	203-225
18192036-3	2008	METHODS AND RESULTS: Using gelatin zymography and RT-PCR and Griess analysis,we found that IL-1beta increased the MMP-2 activity and transcription and nitric oxide(NO) production from supernatant of culture medium.	Nitric Oxide	151-163	interleukin 1 beta	Homo sapiens	91-99
18192036-4	2008	These effects of IL-1beta were inhibited by imidaprilat or the NO synthase inhibitor, L-NMMA.	imidaprilat	44-55	interleukin 1 beta	Homo sapiens	17-25
18192036-4	2008	These effects of IL-1beta were inhibited by imidaprilat or the NO synthase inhibitor, L-NMMA.	omega-N-Methylarginine	86-92	interleukin 1 beta	Homo sapiens	17-25
18192036-8	2008	CONCLUSIONS: The current study demonstrates imidaprilat inhibits MMP-2 activity and expression in human cardiac fibroblasts induced by IL-1beta via NO-dependent pathway.	imidaprilat	44-55	interleukin 1 beta	Homo sapiens	135-143
18276934-3	2008	Excess decidual cell-expressed matrix metalloproteinases (MMPs) 2 and 9, in response to preeclampsia-related interleukin 1 beta (IL1B) and tumor necrosis factor alpha (TNF), may inappropriately degrade these basement membrane proteins and impede EVT invasion.	EVT	246-249	interleukin 1 beta	Homo sapiens	129-133
18081851-3	2008	In this study, we demonstrate that in cultured normal human keratinocytes Mnk1 and its downstream target eukaryotic initiation factor 4E (eIF4E) are phosphorylated in a time-dependent manner in response to stimulation with anisomycin or interleukin (IL)-1beta.	Anisomycin	223-233	interleukin 1 beta	Homo sapiens	237-259
18598258-0	2008	Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta.	Dinoprostone	78-94	interleukin 1 beta	Homo sapiens	121-129
18598258-6	2008	In this study we report that IL-1beta did not modulate NTS synaptic transmission per se, whereas prostaglandin E(2) (PGE(2)), which is produced downstream of IL-1beta, produced opposite effects on spontaneous and evoked release.	Dinoprostone	97-115	interleukin 1 beta	Homo sapiens	158-166
18081851-5	2008	Furthermore, we show that the Mnk inhibitor CGP57380 is capable of inhibiting the phosphorylation of eIF4E in keratinocytes, and that the abolishment of eIF4E phosphorylation dramatically decreases the anisomycin-induced protein release of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), IL-1beta and IL-6 as well as the IL-1beta-induced protein release of TNF-alpha.	CGP 57380	44-52	interleukin 1 beta	Homo sapiens	312-320
18598258-6	2008	In this study we report that IL-1beta did not modulate NTS synaptic transmission per se, whereas prostaglandin E(2) (PGE(2)), which is produced downstream of IL-1beta, produced opposite effects on spontaneous and evoked release.	Prostaglandins E	117-120	interleukin 1 beta	Homo sapiens	158-166
18598258-9	2008	Our data show that IL-1beta-induced PGE(2) can modulate evoked and spontaneous release in the NTS differentially through different mechanisms.	Prostaglandins E	36-39	interleukin 1 beta	Homo sapiens	19-27
18081851-5	2008	Furthermore, we show that the Mnk inhibitor CGP57380 is capable of inhibiting the phosphorylation of eIF4E in keratinocytes, and that the abolishment of eIF4E phosphorylation dramatically decreases the anisomycin-induced protein release of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), IL-1beta and IL-6 as well as the IL-1beta-induced protein release of TNF-alpha.	CGP 57380	44-52	interleukin 1 beta	Homo sapiens	345-353
18457971-9	2008	Treatment with the COX-2 inhibitor (NS-398) or COX-2 antisense oligonucleotides also diminished IL-1beta and IL-6 release.	Oligonucleotides	63-79	interleukin 1 beta	Homo sapiens	96-104
18433786-0	2008	Differential calcium independent regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by interleukin-1beta and transforming growth factor-beta in Peyronie"s plaque fibroblasts.	Calcium	13-20	interleukin 1 beta	Homo sapiens	127-144
18378695-1	2008	The compartmentalized production of superoxide (*O(2)(-)) by endosomal NADPH oxidase is important in the redox-dependent activation of NF-kappaB following interleukin 1beta (IL-1beta) stimulation.	Superoxides	36-46	interleukin 1 beta	Homo sapiens	155-172
18378695-1	2008	The compartmentalized production of superoxide (*O(2)(-)) by endosomal NADPH oxidase is important in the redox-dependent activation of NF-kappaB following interleukin 1beta (IL-1beta) stimulation.	Superoxides	36-46	interleukin 1 beta	Homo sapiens	174-182
18583261-5	2008	RESULTS: In group A, rosiglitazone treatment resulted in significantly reduced serum hs-CRP, IL-1beta, IL-6, TNF-alpha, FPG and insulin resistance index (P&lt;0.01).	Rosiglitazone	21-34	interleukin 1 beta	Homo sapiens	93-101
18054255-14	2008	Pre-incubation for 2h with caspase inhibitors for caspase-3, -7, -8 and pan-caspase significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro; however, apoptosis induced by TNF-alpha+Ro was not modified by indomethacin.	Deuterium	19-21	interleukin 1 beta	Homo sapiens	230-238
18054255-14	2008	Pre-incubation for 2h with caspase inhibitors for caspase-3, -7, -8 and pan-caspase significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro; however, apoptosis induced by TNF-alpha+Ro was not modified by indomethacin.	Indomethacin	181-193	interleukin 1 beta	Homo sapiens	230-238
18054255-16	2008	Indomethacin potentiates the effect of IL-1 on cell death and this may explain the reported effect of indomethacin on the progression of joint destruction.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	39-43
18054255-16	2008	Indomethacin potentiates the effect of IL-1 on cell death and this may explain the reported effect of indomethacin on the progression of joint destruction.	Indomethacin	102-114	interleukin 1 beta	Homo sapiens	39-43
18412147-4	2008	However, pretreatment with Daesiho significantly inhibited the secretion of pro-inflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6, in stimulated PBMCs and THP-1/M cells.	daesiho	27-34	interleukin 1 beta	Homo sapiens	125-133
18263705-2	2008	Chronic high glucose concentrations and leptin induce interleukin-1beta (IL-1beta) secretion from pancreatic islets, an event that is possibly causal in promoting beta-cell dysfunction and death.	Glucose	13-20	interleukin 1 beta	Homo sapiens	54-71
18263705-2	2008	Chronic high glucose concentrations and leptin induce interleukin-1beta (IL-1beta) secretion from pancreatic islets, an event that is possibly causal in promoting beta-cell dysfunction and death.	Glucose	13-20	interleukin 1 beta	Homo sapiens	73-81
18313411-0	2008	Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes.	Carbon Monoxide	0-15	interleukin 1 beta	Homo sapiens	72-80
18313411-3	2008	CO (250ppm) exposure resulted in a significant decrease in iNOS protein, nitrite production, level of active iNOS dimer and cytosolic iNOS activity in cells stimulated with cytokines (IL-1beta) or transfected with the human iNOS gene.	co (250ppm	0-10	interleukin 1 beta	Homo sapiens	184-192
18313411-8	2008	CO was found to increase p38 phosphorylation and p38 inhibition using SB203580 increased iNOS protein levels in response to IL-1beta.	SB 203580	70-78	interleukin 1 beta	Homo sapiens	124-132
18457971-5	2008	p38 MAPK inhibitor SB203580 suppressed interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) release, as well as the activation of cPLA(2).	SB 203580	19-27	interleukin 1 beta	Homo sapiens	39-56
18457971-5	2008	p38 MAPK inhibitor SB203580 suppressed interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) release, as well as the activation of cPLA(2).	SB 203580	19-27	interleukin 1 beta	Homo sapiens	58-66
18457971-6	2008	Transfection of cPLA(2) antisense oligonucleotides or pre-treatment with cPLA(2) inhibitor AACOCF3 abolished IL-1beta and IL-6 release in a dose-dependent manner.	Oligonucleotides	34-50	interleukin 1 beta	Homo sapiens	109-117
18457971-8	2008	As a downstream enzyme of cPLA(2), cyclooxygenase-2 (COX-2) was down-regulated by SB203580 and/or AACOCF(3), which precisely matched the levels of IL-1beta and IL-6.	SB 203580	82-90	interleukin 1 beta	Homo sapiens	147-155
18457971-9	2008	Treatment with the COX-2 inhibitor (NS-398) or COX-2 antisense oligonucleotides also diminished IL-1beta and IL-6 release.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	36-42	interleukin 1 beta	Homo sapiens	96-104
18569862-7	2008	Finally, hypoxia, a common feature of the healing tissue, potentiated the effects exerted by PG on the release of IL-1beta by PBMC.	pg	93-95	interleukin 1 beta	Homo sapiens	114-122
18080123-4	2008	The inhibitors of NF-kappaB, JNK and p38, but not ERK, decreased IL-1beta-enhanced MMP-1, MMP-3 and NO production, respectively, and 100 nM celecoxib down-regulated the phosphorylation of NF-kappaB and JNK but has no effect on either p38 or ERK.	Celecoxib	140-149	interleukin 1 beta	Homo sapiens	65-73
18080123-2	2008	Celecoxib at 100 nM reduced the IL-1beta-induced productions of MMP-1, MMP-3, iNOS, and NO, whereas indomethacin at 100 nM showed no effect.	Celecoxib	0-9	interleukin 1 beta	Homo sapiens	32-40
18462808-0	2008	Interleukin-1beta affects calcium signaling and in vitro cell migration of astrocyte progenitors.	Calcium	26-33	interleukin 1 beta	Homo sapiens	0-17
18080123-2	2008	Celecoxib at 100 nM reduced the IL-1beta-induced productions of MMP-1, MMP-3, iNOS, and NO, whereas indomethacin at 100 nM showed no effect.	Indomethacin	100-112	interleukin 1 beta	Homo sapiens	32-40
18549615-1	2008	This study was purposed to explore the significance of tissue factor (TF), tissue factor pathway inhibitor (IFPI) and interleukin-1beta (IL-1beta) in the evaluation of development, curative effect and prognosis of AL patients.	Aluminum	214-216	interleukin 1 beta	Homo sapiens	137-145
18549615-4	2008	The results showed that as compared with normal control, levels of TF, TFPI and IL-1beta in plasma of AL patients during pre-chemotherapy phase were higher (p &lt; 0.01); as compared with pre-chemotherapy phase, levels of TF, IL-1beta were elevated at 72 hours after -chemotherapy (p &lt; 0.05).	Aluminum	102-104	interleukin 1 beta	Homo sapiens	80-88
18549615-4	2008	The results showed that as compared with normal control, levels of TF, TFPI and IL-1beta in plasma of AL patients during pre-chemotherapy phase were higher (p &lt; 0.01); as compared with pre-chemotherapy phase, levels of TF, IL-1beta were elevated at 72 hours after -chemotherapy (p &lt; 0.05).	Aluminum	102-104	interleukin 1 beta	Homo sapiens	226-234
18462808-3	2008	Here we provide evidence that conditioned medium from activated microglia and interleukin-1beta, but not tumor necrosis factor-alpha, decrease the frequency of calcium oscillations and reduce the rate of in vitro migration of astrocyte progenitors.	Calcium	160-167	interleukin 1 beta	Homo sapiens	78-95
18462808-5	2008	These results indicate that interleukin-1beta plays an important role during early stages of CNS development, modulating calcium signaling and cell migration.	Calcium	121-128	interleukin 1 beta	Homo sapiens	28-45
18433103-2	2008	It was previously demonstrated that stevioside attenuates NF-kappaB-dependent TNF-alpha and IL-1beta synthesis in LPS-stimulated monocytes.	stevioside	36-46	interleukin 1 beta	Homo sapiens	92-100
18480275-7	2008	Consistently, TNFalpha and IL-1beta enhanced AMPA- or NMDA-induced currents, and IL-1beta and IL-6 suppressed GABA- and glycine-induced currents.	Glycine	120-127	interleukin 1 beta	Homo sapiens	81-89
18480275-7	2008	Consistently, TNFalpha and IL-1beta enhanced AMPA- or NMDA-induced currents, and IL-1beta and IL-6 suppressed GABA- and glycine-induced currents.	N-Methylaspartate	54-58	interleukin 1 beta	Homo sapiens	27-35
18291094-0	2008	Interleukin-1beta mediates LPS-induced inhibition of apoptosis in retinoic acid-differentiated HL-60 cells.	Tretinoin	66-79	interleukin 1 beta	Homo sapiens	0-17
18480275-7	2008	Consistently, TNFalpha and IL-1beta enhanced AMPA- or NMDA-induced currents, and IL-1beta and IL-6 suppressed GABA- and glycine-induced currents.	gamma-Aminobutyric Acid	110-114	interleukin 1 beta	Homo sapiens	81-89
18438860-8	2008	Visfatin, like IL-1beta, triggered excessive release of PGE2, due to increased mPGES-1 synthesis and decreased 15-PGDH synthesis.	Dinoprostone	56-60	interleukin 1 beta	Homo sapiens	15-23
18438814-10	2008	An overall low level of IL-1beta secretion upon exposure to exogenous ATP was observed, unrelated to treatment responsiveness or disease activity.	Adenosine Triphosphate	70-73	interleukin 1 beta	Homo sapiens	24-32
18438860-9	2008	Visfatin knockout with siRNA reduced IL-1beta-induced PGE2 overrelease.	Dinoprostone	54-58	interleukin 1 beta	Homo sapiens	37-45
18387520-7	2008	While overnight incubation of HCMC with IgE significantly increased the expression of NOS2 and NOS3, only NOS2 expression was up-regulated after overnight incubation with a mixture of TNF-alpha, IFN-gamma and IL-1beta.	hcmc	30-34	interleukin 1 beta	Homo sapiens	209-217
18438844-4	2008	Induction of miR-146 following stimulation with tumor necrosis factor alpha (TNFalpha) and interleukin-1beta (IL-1beta) of cultures of human rheumatoid arthritis synovial fibroblasts (RASFs) was examined by quantitative PCR and RT-PCR.	mir-146	13-20	interleukin 1 beta	Homo sapiens	91-108
18438844-4	2008	Induction of miR-146 following stimulation with tumor necrosis factor alpha (TNFalpha) and interleukin-1beta (IL-1beta) of cultures of human rheumatoid arthritis synovial fibroblasts (RASFs) was examined by quantitative PCR and RT-PCR.	mir-146	13-20	interleukin 1 beta	Homo sapiens	110-118
18715885-0	2008	IL-1beta as a determinant in silica-induced cytokine responses in monocyte-endothelial cell co-cultures.	Silicon Dioxide	29-35	interleukin 1 beta	Homo sapiens	0-8
18715885-3	2008	The time courses for silica-induced release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-8 both from co-cultures and monocyte mono-cultures showed an early peak at 5-10 h, almost no response at 20 h, and a strong increase at 43 h. At 43 h, co-cultures also showed strongly increased IL-6 levels.	Silicon Dioxide	21-27	interleukin 1 beta	Homo sapiens	82-104
18715885-4	2008	Steady-state levels of mRNA roughly exhibited the same pattern of early up-regulation and reduced levels at 20 h. Compared with monocyte mono-cultures, silica induced a strong release of IL-1beta, IL-6, and IL-8, but not of TNF-alpha, after 43 h in co-cultures, whereas at 5 and 10 h a significant difference was only observed for the silica-induced IL-8 response.	Silicon Dioxide	152-158	interleukin 1 beta	Homo sapiens	187-195
18715885-6	2008	Thus, IL-1beta is suggested to be an important triggering factor that determines the silica-induced release of several of the other cytokines in this co-culture system.	Silicon Dioxide	85-91	interleukin 1 beta	Homo sapiens	6-14
18313744-9	2008	Experiments employing neutralising antibodies indicate that exposure of co-cultured macrophages to both Ti-based particles induces the release of M-CSF, GM-CSF, IL-6 and PGE2 through up-regulation of IL-1beta and TNF-alpha.	Dinoprostone	170-174	interleukin 1 beta	Homo sapiens	200-208
18080321-0	2008	Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts.	Glucosamine hydrochloride	29-44	interleukin 1 beta	Homo sapiens	116-133
18436837-0	2008	Dexamethasone inhibits high glucose-, TNF-alpha-, and IL-1beta-induced secretion of inflammatory and angiogenic mediators from retinal microvascular pericytes.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	54-62
18038269-0	2008	Lysophosphatidic acid-induced interleukin-1 beta expression is mediated through Gi/Rho and the generation of reactive oxygen species in macrophages.	lysophosphatidic acid	0-21	interleukin 1 beta	Homo sapiens	30-48
18038269-0	2008	Lysophosphatidic acid-induced interleukin-1 beta expression is mediated through Gi/Rho and the generation of reactive oxygen species in macrophages.	Reactive Oxygen Species	109-132	interleukin 1 beta	Homo sapiens	30-48
18359139-8	2008	Also exposure to TEGDMA-based composite resin significantly increased the amount of IL-1beta released from the oral mucosal model.	triethylene glycol dimethacrylate	17-23	interleukin 1 beta	Homo sapiens	84-92
18038269-3	2008	By using pharmacological inhibitors, it was suggested that G(i)/Rho activation and subsequent reactive oxygen species (ROS) production were involved in IL-1 beta induction.	Reactive Oxygen Species	94-117	interleukin 1 beta	Homo sapiens	152-161
18038269-3	2008	By using pharmacological inhibitors, it was suggested that G(i)/Rho activation and subsequent reactive oxygen species (ROS) production were involved in IL-1 beta induction.	Reactive Oxygen Species	119-122	interleukin 1 beta	Homo sapiens	152-161
18038269-4	2008	In addition, IL-1 beta induction by LPA was also observed in human primary macrophages.	lysophosphatidic acid	36-39	interleukin 1 beta	Homo sapiens	13-22
18454664-9	2008	In GCF, cystatin C levels were higher in PHC (P &gt;0.05), whereas TNF-alpha and IL-1beta levels were higher in CG (P &gt;0.05).	cg	112-114	interleukin 1 beta	Homo sapiens	81-89
18454664-10	2008	In the CG group, there were positive correlations between the GCF cystatin C level and the PI of the sampled site (r = 0.488; P &lt;0.05); also, GCF IL-1beta (r = 0.603; P &lt;0.05) and TNF-alpha (r = 0.456; P &lt;0.05) levels were positively correlated with PD and CAL.	cg	7-9	interleukin 1 beta	Homo sapiens	149-157
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	15-deoxy-delta12,14-prostaglandin-j	0-35	interleukin 1 beta	Homo sapiens	117-134
29539199-9	2008	In GCF, cystatin C levels were higher in PHC (P &gt;0.05), whereas TNF-alpha and IL-1beta levels were higher in CG (P &gt;0.05).	cg	112-114	interleukin 1 beta	Homo sapiens	81-89
29539199-10	2008	In the CG group, there were positive correlations between the GCF cystatin C level and the PI of the sampled site (r = 0.488; P &lt;0.05); also, GCF IL-1beta (r = 0.603; P &lt;0.05) and TNF-alpha (r = 0.456; P &lt;0.05) levels were positively correlated with PD and CAL.	cg	7-9	interleukin 1 beta	Homo sapiens	149-157
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	15-deoxy-delta12,14-prostaglandin-j	0-35	interleukin 1 beta	Homo sapiens	136-144
18456507-10	2008	Furthermore, preincubation with 15d-PGJ(2) inhibited IL-1beta-induced PGE(2) production although IL-1beta-induced COX-2 expression remained unaffected by the treatment with 15d-PGJ(2).	15d-pgj	32-39	interleukin 1 beta	Homo sapiens	53-61
18456507-10	2008	Furthermore, preincubation with 15d-PGJ(2) inhibited IL-1beta-induced PGE(2) production although IL-1beta-induced COX-2 expression remained unaffected by the treatment with 15d-PGJ(2).	Prostaglandins E	70-73	interleukin 1 beta	Homo sapiens	53-61
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	-pgj	43-47	interleukin 1 beta	Homo sapiens	117-134
18456507-11	2008	On the contrary, PGA(2) elicited an increase in PGE(2) production and it acted synergistically with IL-1beta to enhance PGE(2) production.	prostaglandin A2	17-23	interleukin 1 beta	Homo sapiens	100-108
18456507-11	2008	On the contrary, PGA(2) elicited an increase in PGE(2) production and it acted synergistically with IL-1beta to enhance PGE(2) production.	Prostaglandins E	120-123	interleukin 1 beta	Homo sapiens	100-108
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	-pgj	43-47	interleukin 1 beta	Homo sapiens	136-144
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	Prostaglandins E	197-212	interleukin 1 beta	Homo sapiens	117-134
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	Prostaglandins E	197-212	interleukin 1 beta	Homo sapiens	136-144
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	Prostaglandins E	217-220	interleukin 1 beta	Homo sapiens	117-134
18456507-1	2008	15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types.	Prostaglandins E	217-220	interleukin 1 beta	Homo sapiens	136-144
18040764-2	2008	A stimulus such as ATP is necessary to cause the release of mature IL-1beta, via activation of the P2X(7) receptor on monocytes.	Adenosine Triphosphate	19-22	interleukin 1 beta	Homo sapiens	67-75
18375401-4	2008	RESULTS: Diacerein and NSAIDs inhibited IL-1beta-stimulated NF-kappaB activation in synoviocytes and chondrocytes except indomethacin in synoviocytes.	diacerein	9-18	interleukin 1 beta	Homo sapiens	40-48
18375401-5	2008	Diacerein further increased COX-2 protein expression and PGE2 synthesis in synoviocytes stimulated with IL-1beta, while no effect was observed on stimulated chondrocytes.	diacerein	0-9	interleukin 1 beta	Homo sapiens	104-112
18446054-4	2008	Multiple regression analysis showed significant association of the IL-1B-511CC and ACE DD polymorphisms with ERI (P=0.038 and P=0.004 in the recessive model, respectively).	3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose	109-112	interleukin 1 beta	Homo sapiens	67-72
18306389-9	2008	Treatment of OVCAR-3 cells with LMB revealed a significant reduction of cell proliferation and increased apoptosis as well as suppressed interleukin-1beta-induced COX-2 expression.	leptomycin B	32-35	interleukin 1 beta	Homo sapiens	137-154
18237545-5	2008	These antibodies also decreased the basal PA-activity of HT-29 cells and neutralized their cytokines (Interleukin-1beta+Interleukin-6)-enhanced PA-activity.	Protactinium	144-146	interleukin 1 beta	Homo sapiens	102-119
18212111-1	2008	The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes.	Roxithromycin	187-200	interleukin 1 beta	Homo sapiens	114-131
18212111-1	2008	The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes.	Erythromycin	202-214	interleukin 1 beta	Homo sapiens	114-131
18212111-1	2008	The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes.	Clarithromycin	220-234	interleukin 1 beta	Homo sapiens	114-131
18383392-7	2008	Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis (OA), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta, lipopolysaccharide, poly(I-C), and bacterial lipoprotein.	Poly I-C	230-238	interleukin 1 beta	Homo sapiens	191-208
18353001-8	2008	The most consistent result was a peak of cytokine levels at 24 h. Associations existed between prostaglandin E(2) (PGE(2)) and interleukin-1beta (IL-1beta) and pain, velocity of tooth movement, and treatment mechanics.	Dinoprostone	95-113	interleukin 1 beta	Homo sapiens	127-144
18353001-8	2008	The most consistent result was a peak of cytokine levels at 24 h. Associations existed between prostaglandin E(2) (PGE(2)) and interleukin-1beta (IL-1beta) and pain, velocity of tooth movement, and treatment mechanics.	Dinoprostone	95-113	interleukin 1 beta	Homo sapiens	146-154
18353001-8	2008	The most consistent result was a peak of cytokine levels at 24 h. Associations existed between prostaglandin E(2) (PGE(2)) and interleukin-1beta (IL-1beta) and pain, velocity of tooth movement, and treatment mechanics.	Prostaglandins E	115-118	interleukin 1 beta	Homo sapiens	127-144
18353001-8	2008	The most consistent result was a peak of cytokine levels at 24 h. Associations existed between prostaglandin E(2) (PGE(2)) and interleukin-1beta (IL-1beta) and pain, velocity of tooth movement, and treatment mechanics.	Prostaglandins E	115-118	interleukin 1 beta	Homo sapiens	146-154
18353001-9	2008	Interleukin-1beta and PGE(2) showed different patterns of up-regulation, with IL-1beta being more responsive to mechanical stress and PGE(2) more responsive to synergistic regulation of IL-1beta and mechanical force.	Prostaglandins E	22-25	interleukin 1 beta	Homo sapiens	78-86
18353001-9	2008	Interleukin-1beta and PGE(2) showed different patterns of up-regulation, with IL-1beta being more responsive to mechanical stress and PGE(2) more responsive to synergistic regulation of IL-1beta and mechanical force.	Prostaglandins E	22-25	interleukin 1 beta	Homo sapiens	186-194
18353001-9	2008	Interleukin-1beta and PGE(2) showed different patterns of up-regulation, with IL-1beta being more responsive to mechanical stress and PGE(2) more responsive to synergistic regulation of IL-1beta and mechanical force.	Prostaglandins E	134-137	interleukin 1 beta	Homo sapiens	0-17
18353001-9	2008	Interleukin-1beta and PGE(2) showed different patterns of up-regulation, with IL-1beta being more responsive to mechanical stress and PGE(2) more responsive to synergistic regulation of IL-1beta and mechanical force.	Prostaglandins E	134-137	interleukin 1 beta	Homo sapiens	186-194
18353310-5	2008	The topical application of a low dose (10 pg, 1 ng, or 100 ng/wound area) of asiaticoside increased monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and interleukin (IL)-1beta levels in burn wound exudates.	asiaticoside	77-89	interleukin 1 beta	Homo sapiens	191-213
18353310-7	2008	Furthermore, asiaticoside (10 pg to 100 ng/ml) increased the IL-1beta production in THP-1 macrophages with MCP-1, but it had no effect on IL-1beta production without MCP-1 or with lipopolysaccharide (LPS).	asiaticoside	13-25	interleukin 1 beta	Homo sapiens	61-69
18353310-8	2008	These findings suggest that the enhancement of burn wound healing by asiaticoside might be due to the promotion of angiogenesis during skin wound repair as a result of the stimulation of VEGF production caused by the increase in MCP-1 expression in keratinocytes and the increase in IL-1beta expression in macrophages induced cooperatively by asiaticoside plus MCP-1.	asiaticoside	69-81	interleukin 1 beta	Homo sapiens	283-291
18164123-3	2008	1-BP dose-dependently induced the production of NO and proinflammatory cytokines, such as IL-1beta, IL-6, and TNF-alpha, and expression levels of these genes also increased in a dose-dependent manner.	1-bromopropane	0-4	interleukin 1 beta	Homo sapiens	90-98
18297103-0	2008	A nitric oxide/Ca(2+)/calmodulin/ERK1/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1beta in human astrocytoma cells.	Nitric Oxide	2-14	interleukin 1 beta	Homo sapiens	120-128
18297103-5	2008	Pretreatment with the nonspecific NOS inhibitor, N-omega-nitro-l-arginine methyl ester (L-NAME) or the selective iNOS inhibitor, N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride (1400W), antagonized ERK activation and cell proliferation induced by IL-1beta.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	129-193	interleukin 1 beta	Homo sapiens	264-272
18040764-3	2008	In this study, the production of IL-1beta in whole blood after ATP stimulation and expression of P2X(7) receptors in RA and healthy subjects were examined.	Adenosine Triphosphate	63-66	interleukin 1 beta	Homo sapiens	33-41
18040764-7	2008	ATP induced significantly higher levels of IL-1beta in LPS-activated RA blood samples compared to controls.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	43-51
18187519-4	2008	DNP treatment of the human THP-1 macrophage cell line resulted in reduced ATP synthesis, and, although hyporesponsive to LPS, the metabolically stressed macrophages produced IL-1beta, IL-6, and TNF-alpha.	Dinitrophenols	0-3	interleukin 1 beta	Homo sapiens	174-182
18021297-7	2008	LPS-induced nuclear factor kappa B activation was inhibited by DHA, hence, LPS-induced proinflammatory cytokine synthesis of interleukin-1beta and tumor necrosis factor alpha was strongly attenuated.	Docosahexaenoic Acids	63-66	interleukin 1 beta	Homo sapiens	125-174
18195133-0	2008	The carbon monoxide-releasing molecule tricarbonyldichlororuthenium(II) dimer protects human osteoarthritic chondrocytes and cartilage from the catabolic actions of interleukin-1beta.	Carbon Monoxide	4-19	interleukin 1 beta	Homo sapiens	165-182
18195133-0	2008	The carbon monoxide-releasing molecule tricarbonyldichlororuthenium(II) dimer protects human osteoarthritic chondrocytes and cartilage from the catabolic actions of interleukin-1beta.	tricarbonyldichlororuthenium(ii)	39-71	interleukin 1 beta	Homo sapiens	165-182
18195133-1	2008	We have investigated the effects of a carbon monoxide-releasing molecule, tricarbonyldichlororuthenium(II) dimer (CORM-2), on catabolic processes in human osteoarthritis (OA) cartilage and chondrocytes activated with interleukin-1beta.	tricarbonyldichlororuthenium	74-102	interleukin 1 beta	Homo sapiens	217-234
18242710-6	2008	Our study revealed that LPS-stimulated THP-1 cells treated with simvastatin had an increased caspase-1 mediated processing of proIL-1beta.	Simvastatin	64-75	interleukin 1 beta	Homo sapiens	126-137
18242710-10	2008	Taken together, these results demonstrate that simvastatin augments LPS-induced IL-1beta release post-translationally, by inducing caspase-1 activity.	Simvastatin	47-58	interleukin 1 beta	Homo sapiens	80-88
18156442-0	2008	IL-1beta, BK, and TGF-beta1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA.	Epoprostenol	38-42	interleukin 1 beta	Homo sapiens	0-8
18156442-0	2008	IL-1beta, BK, and TGF-beta1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA.	Cyclic AMP	52-56	interleukin 1 beta	Homo sapiens	0-8
18156442-1	2008	We have previously shown that interleukin (IL)-1beta, transforming growth factor (TGF)-beta1, or bradykinin (BK) impair cAMP generation in response to prostacyclin analogs in human pulmonary artery smooth muscle (PASM), suggesting that inflammation can impair the effects of prostacyclin analogs on PASM in pulmonary hypertension.	Cyclic AMP	120-124	interleukin 1 beta	Homo sapiens	30-52
18156442-1	2008	We have previously shown that interleukin (IL)-1beta, transforming growth factor (TGF)-beta1, or bradykinin (BK) impair cAMP generation in response to prostacyclin analogs in human pulmonary artery smooth muscle (PASM), suggesting that inflammation can impair the effects of prostacyclin analogs on PASM in pulmonary hypertension.	Epoprostenol	151-163	interleukin 1 beta	Homo sapiens	30-52
18156442-1	2008	We have previously shown that interleukin (IL)-1beta, transforming growth factor (TGF)-beta1, or bradykinin (BK) impair cAMP generation in response to prostacyclin analogs in human pulmonary artery smooth muscle (PASM), suggesting that inflammation can impair the effects of prostacyclin analogs on PASM in pulmonary hypertension.	Epoprostenol	275-287	interleukin 1 beta	Homo sapiens	30-52
18156442-6	2008	Fluorescent kemptide assay and Western blotting confirmed that PKA and p38 MAP kinase were activated by IL-1beta, BK, and TGF-beta1.	kemptide	12-20	interleukin 1 beta	Homo sapiens	104-112
18156442-7	2008	These studies suggest that IL-1beta, BK, and TGF-beta1 impair IP receptor-mediated cAMP accumulation by multiple effects on different components of the signaling pathway and that these effects are PKA and p38 MAP kinase dependent.	Cyclic AMP	83-87	interleukin 1 beta	Homo sapiens	27-35
18308354-7	2008	We found that deoxynivalenol, ochratoxin A and patulin all potentiated the effect of IL-1beta on IL-8 secretion (ranging from 35% to 138% increase) and increased the transepithelial passage of commensal bacteria (ranging from 12- to 1544-fold increase).	deoxynivalenol	14-28	interleukin 1 beta	Homo sapiens	85-93
18308354-7	2008	We found that deoxynivalenol, ochratoxin A and patulin all potentiated the effect of IL-1beta on IL-8 secretion (ranging from 35% to 138% increase) and increased the transepithelial passage of commensal bacteria (ranging from 12- to 1544-fold increase).	ochratoxin A	30-42	interleukin 1 beta	Homo sapiens	85-93
18664200-3	2008	The modulation of cetirizine on the production of interferon (IFN)-gamma, interleukin (IL)-1beta, IL-6 and IL-8 in HaCaT cells and fibroblasts was measured by ELISA.	Cetirizine	18-28	interleukin 1 beta	Homo sapiens	74-96
18664200-6	2008	Cetirizine 1-100 micromol x L(-1) inhibited SP-induced IL-1beta and IL-8 production in HaCaT cells and fibroblasts, while had no effect on the production of IFN-gamma in both cells.	cetirizine 1	0-12	interleukin 1 beta	Homo sapiens	55-63
18664200-8	2008	These findings suggest that cetirizine may be involved in the treatment of SP-induced skin inflammation by inhibiting the expression of substance P receptor and regulation the production of IL-1beta and IL-8 in epidermal keratinocyte and dermal fibroblasts.	Cetirizine	28-38	interleukin 1 beta	Homo sapiens	190-198
18239058-7	2008	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed IL-1beta-, IFN-gamma-, and TNF-alpha-induced IL-32alpha mRNA expression, although MAPK inhibitors had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interleukin 1 beta	Homo sapiens	82-90
18239058-9	2008	Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha-induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma-induced activated protein-1 (AP-1) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interleukin 1 beta	Homo sapiens	38-46
18239058-9	2008	Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha-induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma-induced activated protein-1 (AP-1) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interleukin 1 beta	Homo sapiens	95-103
18565252-16	2008	The resorption activity of the L OA cells was significantly inhibited by all treatments except IL-1Beta, with maximum effect observed with vitamin D(3) and PGE(2).	Vitamin D	139-148	interleukin 1 beta	Homo sapiens	95-103
18565252-16	2008	The resorption activity of the L OA cells was significantly inhibited by all treatments except IL-1Beta, with maximum effect observed with vitamin D(3) and PGE(2).	Prostaglandins E	156-159	interleukin 1 beta	Homo sapiens	95-103
18028863-1	2008	Glutathione transferase omega 1-1 (GSTO1-1) catalyzes the biotransformation of arsenic and is implicated as a factor influencing the age-at-onset of Alzheimer"s disease and the posttranslational activation of interleukin 1beta (IL-1beta).	Arsenic	79-86	interleukin 1 beta	Homo sapiens	209-226
18028863-1	2008	Glutathione transferase omega 1-1 (GSTO1-1) catalyzes the biotransformation of arsenic and is implicated as a factor influencing the age-at-onset of Alzheimer"s disease and the posttranslational activation of interleukin 1beta (IL-1beta).	Arsenic	79-86	interleukin 1 beta	Homo sapiens	228-236
17763959-11	2008	Ghrelin caused a decrease in TNFalpha-induced COX-2 and IL-1beta expression in OE-19 cells.	Ghrelin	0-7	interleukin 1 beta	Homo sapiens	56-64
18177344-5	2008	SAPK/JNK-specific inhibitor SP600125 slightly suppressed IL-6 production although no evident effects were obtained for TNF-alpha and IL-1beta; ERK1/2 inhibitor PD98059 blocked both TNF-alpha and IL-1beta, but not IL-6 production.	pyrazolanthrone	28-36	interleukin 1 beta	Homo sapiens	195-203
18177344-5	2008	SAPK/JNK-specific inhibitor SP600125 slightly suppressed IL-6 production although no evident effects were obtained for TNF-alpha and IL-1beta; ERK1/2 inhibitor PD98059 blocked both TNF-alpha and IL-1beta, but not IL-6 production.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	160-167	interleukin 1 beta	Homo sapiens	195-203
18266269-4	2008	PPG 1200 was the most potent inhibitor tested, shown for TNF, IL-1beta, IL-6, IL-8, IL-10 and TGF-beta induction, and displayed no cytotoxic effects.	ppg 1200	0-8	interleukin 1 beta	Homo sapiens	62-70
18344608-2	2008	GL, as well as dexamethasone (DEX) inhibited both tumor necrosis factor (TNF)-alpha- and IL-1beta-induced IL-8 production, mRNA expression, and promoter activity in A549 cells.	Dexamethasone	30-33	interleukin 1 beta	Homo sapiens	89-97
18344712-10	2008	CONCLUSIONS: Genotyping of the (+3954C/T) polymorphism of IL-1beta could be useful in patients starting highly active antiretroviral therapy, especially in potential users of stavudine, to predict their risk of developing lipodystrophic syndrome.	Stavudine	175-184	interleukin 1 beta	Homo sapiens	58-66
18247123-3	2008	We hypothesized that morphine may alter regulation of the C3 gene by IL-1beta in astrocytes.	Morphine	21-29	interleukin 1 beta	Homo sapiens	69-77
18247123-8	2008	Taken together, this study illustrates that morphine modulates IL-1beta-mediated C3 expression in astrocytic cells.	Morphine	44-52	interleukin 1 beta	Homo sapiens	63-71
18177344-6	2008	However, p38 inhibitor SB203580 abrogated TNF-alpha, IL-1beta and IL-6 production.	SB 203580	23-31	interleukin 1 beta	Homo sapiens	53-61
18300858-4	2008	However, the high concentration of D-glucose did increase iNOS expression in response to low concentrations of IL-1beta (2.5 and 5 ng/ml), as well as the IL-1beta-induced activation of both ERK 1/2 and NF-kappaB.	Glucose	35-44	interleukin 1 beta	Homo sapiens	111-119
18300858-4	2008	However, the high concentration of D-glucose did increase iNOS expression in response to low concentrations of IL-1beta (2.5 and 5 ng/ml), as well as the IL-1beta-induced activation of both ERK 1/2 and NF-kappaB.	Glucose	35-44	interleukin 1 beta	Homo sapiens	154-162
18300858-5	2008	D-glucose also enhanced, concentration-dependently, the expression and activity of iNOS induced by co-incubation with IL-1beta (10 ng/ml).	Glucose	0-9	interleukin 1 beta	Homo sapiens	118-126
18300858-6	2008	Pretreatment with IL-1beta sensitized the cells to the subsequent effects of high D-glucose.	Glucose	82-91	interleukin 1 beta	Homo sapiens	18-26
18300858-7	2008	CONCLUSIONS: The results indicate that high concentrations of D-glucose exacerbate the pro-inflammatory effects of IL-1beta.	Glucose	62-71	interleukin 1 beta	Homo sapiens	115-123
18200630-5	2008	Up-regulation of HO-1 by cobalt protoporphyrin IX significantly reduced glycosaminoglycan degradation elicited by IL-1beta in OA cartilage explants but increased glycosaminoglycan synthesis and the expression of collagen II in OA chondrocytes in primary culture, as determined by radiometric procedures, immunoblotting and immunocytochemistry.	cobaltiprotoporphyrin	25-49	interleukin 1 beta	Homo sapiens	114-122
18200630-5	2008	Up-regulation of HO-1 by cobalt protoporphyrin IX significantly reduced glycosaminoglycan degradation elicited by IL-1beta in OA cartilage explants but increased glycosaminoglycan synthesis and the expression of collagen II in OA chondrocytes in primary culture, as determined by radiometric procedures, immunoblotting and immunocytochemistry.	Glycosaminoglycans	72-89	interleukin 1 beta	Homo sapiens	114-122
18344608-2	2008	GL, as well as dexamethasone (DEX) inhibited both tumor necrosis factor (TNF)-alpha- and IL-1beta-induced IL-8 production, mRNA expression, and promoter activity in A549 cells.	Glycyrrhizic Acid	0-2	interleukin 1 beta	Homo sapiens	89-97
18344608-2	2008	GL, as well as dexamethasone (DEX) inhibited both tumor necrosis factor (TNF)-alpha- and IL-1beta-induced IL-8 production, mRNA expression, and promoter activity in A549 cells.	Dexamethasone	15-28	interleukin 1 beta	Homo sapiens	89-97
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	176-180	interleukin 1 beta	Homo sapiens	124-132
18082228-6	2008	To examine the role of the melanocortins in mediating IL-1beta- induced metabolic changes, animals were pretreated centrally with a melanocortin receptor antagonist, HS014.	HS014	166-171	interleukin 1 beta	Homo sapiens	54-62
18082228-7	2008	Pretreatment with HS014 blocked the effect of IL-1beta on food intake and RER at later time points (beyond 8 h post injection), as well as the hypoactivity and increased metabolic rate.	HS014	18-23	interleukin 1 beta	Homo sapiens	46-54
18224250-7	2008	Inhibition of p38 mitogen-activated protein kinase (MAPK) by SB203580 counteracted the influence of IL-1beta on Fhl2 and Tubb expression, indicating partial involvement of this signaling pathway.	SB 203580	61-69	interleukin 1 beta	Homo sapiens	100-108
18089838-7	2008	TCDD-mediated inductions of various AhR targets, such as the drug metabolizing CYP1B1, the cytokine interleukin-1beta, the chemokines interleukin-8 and CCL1, the adhesion molecule beta7 integrin, and the AhR repressor, were also prevented by KN-93 in human macrophages.	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Homo sapiens	100-117
18326322-4	2008	However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system.	Iron	246-250	interleukin 1 beta	Homo sapiens	124-132
17951278-9	2008	Lung lavage fluid from patients treated with salbutamol enhanced wound repair responses compared with placebo treated patients in vitro by an interleukin 1beta dependent mechanism.	Albuterol	45-55	interleukin 1 beta	Homo sapiens	142-159
17707661-8	2008	The degradation of I-kappa B alpha is prevented in the presence of ASU as shown by the persistent expression of I-kappa B alpha protein in the cytosol when chondrocytes are stimulated by IL1beta or MS. Nuclear translocation of the NF-kappaB complex is shown by the decrease of the p65 protein from the cytosol, whereas p65 appears in the nucleus under IL1beta stimulation.	asu	67-70	interleukin 1 beta	Homo sapiens	187-194
17707661-8	2008	The degradation of I-kappa B alpha is prevented in the presence of ASU as shown by the persistent expression of I-kappa B alpha protein in the cytosol when chondrocytes are stimulated by IL1beta or MS. Nuclear translocation of the NF-kappaB complex is shown by the decrease of the p65 protein from the cytosol, whereas p65 appears in the nucleus under IL1beta stimulation.	asu	67-70	interleukin 1 beta	Homo sapiens	352-359
17707661-10	2008	Moreover, bandshift experiments show an inhibition of the IL1beta-induced binding of p50/p65 complexes to NF-kappaB responsive elements in response to ASU.	asu	151-154	interleukin 1 beta	Homo sapiens	58-65
17707661-11	2008	Finally, among the different mitogen-activated protein kinases known to be induced by IL1beta, ERK1/2 was the sole kinase inhibited by ASU.	asu	135-138	interleukin 1 beta	Homo sapiens	86-93
18572770-2	2008	The addition of azoximer injections to basic treatment of chronic prostatitis improves or normalizes the majority of abnormal parameters of immune and cytokine status except neutrophil phagocyte activity, IL-1beta concentration in the blood serum, IL-6 and IL-1beta concentration in prostatic gland secretion.	azoximer	16-24	interleukin 1 beta	Homo sapiens	205-213
18327406-8	2008	Under serum-free conditions, heparin demonstrated dose-dependent anti-inflammatory effects, significantly reducing secretion of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8, and TNF-alpha) in response to LPS-stimulation of THP-1 cells and primary monocytes.	Heparin	29-36	interleukin 1 beta	Homo sapiens	156-164
18572770-2	2008	The addition of azoximer injections to basic treatment of chronic prostatitis improves or normalizes the majority of abnormal parameters of immune and cytokine status except neutrophil phagocyte activity, IL-1beta concentration in the blood serum, IL-6 and IL-1beta concentration in prostatic gland secretion.	azoximer	16-24	interleukin 1 beta	Homo sapiens	257-265
18382052-0	2008	[Effect of IGF-1 on NO and PGE2 in rabbit articular chondrocytes induced by IL-1].	Dinoprostone	27-31	interleukin 1 beta	Homo sapiens	76-80
18382052-9	2008	CONCLUSION: IL-1 can significantly increase the concentration of NO and PGE(2), and IGF-1 can dose-dependently decrease the concentration of NO and PGE(2) in the chondrocytes supernatant in vitro.	Prostaglandins E	72-75	interleukin 1 beta	Homo sapiens	12-16
18642783-10	2008	The levels of TNF-alpha, IL-6, and IL-8 of the high concentration Gln 2 h groups were all significantly higher then those of the concentration Gln 0.5 h groups (all P &lt;0.01), however, there was not significant difference in the level of IL-1beta between the high concentration 0.5 h and 2 h Gln groups.	Glutamine	66-69	interleukin 1 beta	Homo sapiens	240-248
18382052-1	2008	OBJECTIVE: To explore the effect of insulin-like growth factor (IGF-1) on the concentration of NO and PGE(2) in the supernatant of rabbit articular chondrocytes induced by IL-1, and to explore the mechanism of IGF-1 in the development of osteoarthritis (OA).	Dinoprostone	102-108	interleukin 1 beta	Homo sapiens	172-176
17959154-8	2008	Additionally, resveratrol reversed the IL-1beta-induced up-regulation of reactive oxygen species (ROS) in chondrocytes.	Reactive Oxygen Species	73-96	interleukin 1 beta	Homo sapiens	39-47
18278132-5	2008	RESULTS: The concentrations of IL-1beta in AgP patients were significantly higher than those in healthy controls (7.23 ng/L vs 3.52 ng/L, P=0.003), which were positively correlated with BI, PD, AL and the percentage of severe sites (r=0.170, P=0.038; r=0.175, P=0.033; r=0.168, P=0.040; r=0.236, P=0.004).	Bismuth	186-188	interleukin 1 beta	Homo sapiens	31-39
18278132-5	2008	RESULTS: The concentrations of IL-1beta in AgP patients were significantly higher than those in healthy controls (7.23 ng/L vs 3.52 ng/L, P=0.003), which were positively correlated with BI, PD, AL and the percentage of severe sites (r=0.170, P=0.038; r=0.175, P=0.033; r=0.168, P=0.040; r=0.236, P=0.004).	Aluminum	194-196	interleukin 1 beta	Homo sapiens	31-39
17981262-4	2008	We show that 5-ASA down-regulates both constitutive and TNF-alpha or IL-1beta-induced COX-2 in HT-115 and HT-29 cells.	Mesalamine	13-18	interleukin 1 beta	Homo sapiens	69-77
18065658-10	2008	An anti-IL-1beta antibody partially (&gt;50%) inhibited the BALF-induced HGF and PGE(2) secretion, whereas NS-398, a specific cyclooxygenase-2 (COX-2) inhibitor, completely inhibited it.	Prostaglandins E	81-84	interleukin 1 beta	Homo sapiens	8-16
18065658-12	2008	Therefore, IL-1beta is a main BALF mediator involved in HGF secretion, which is mediated through a PGE(2)/COX-2-dependent mechanism.	Prostaglandins E	99-102	interleukin 1 beta	Homo sapiens	11-19
17959154-4	2008	We first examined the effects of resveratrol on the proliferation and production of IL-1beta in primary human articular chondrocytes treated with IL-1betain vitro.	Resveratrol	33-44	interleukin 1 beta	Homo sapiens	84-92
17959154-8	2008	Additionally, resveratrol reversed the IL-1beta-induced up-regulation of reactive oxygen species (ROS) in chondrocytes.	Reactive Oxygen Species	98-101	interleukin 1 beta	Homo sapiens	39-47
17959154-5	2008	Resveratrol reversed significantly IL-1beta-reduced cell proliferation and blocked IL-1beta-stimulated cell membrane bound- and mature IL-1beta synthesis in chondrocytes.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	35-43
17959154-5	2008	Resveratrol reversed significantly IL-1beta-reduced cell proliferation and blocked IL-1beta-stimulated cell membrane bound- and mature IL-1beta synthesis in chondrocytes.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	83-91
17959154-10	2008	Our results indicate that resveratrol seems to be an effective in vitro anti-inflammatory agent and has a chondroprotective capacity through suppression of (1) IL-1beta- (2) ROS- and (3) tumor suppressor protein p53-production.	Resveratrol	26-37	interleukin 1 beta	Homo sapiens	160-168
17959154-5	2008	Resveratrol reversed significantly IL-1beta-reduced cell proliferation and blocked IL-1beta-stimulated cell membrane bound- and mature IL-1beta synthesis in chondrocytes.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	83-91
17959154-6	2008	Furthermore, resveratrol was able to inhibit the IL-1beta-induced degradation of mitochondria and apoptosis in chondrocytes in a time-dependent manner.	Resveratrol	13-24	interleukin 1 beta	Homo sapiens	49-57
17959154-7	2008	Because caspase inhibitor Z-DEVD-FMK abolished the IL-1beta-induced apoptosis in chondrocytes, we examined the effect of resveratrol on the caspase pathway and found that resveratrol blocked the cysteine protease caspase-3 and subsequent cleavage of the DNA repair enzyme PARP.	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	26-36	interleukin 1 beta	Homo sapiens	51-59
17993511-2	2008	The inflammatory cytokines interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha) have been shown previously to inhibit mitogen-stimulated smooth muscle growth through a mechanism presumed to be dependent on the induction of cyclooxygenase-2, prostaglandins, and activation of the cAMP-dependent protein kinase (PKA).	Prostaglandins	255-269	interleukin 1 beta	Homo sapiens	27-49
17959154-7	2008	Because caspase inhibitor Z-DEVD-FMK abolished the IL-1beta-induced apoptosis in chondrocytes, we examined the effect of resveratrol on the caspase pathway and found that resveratrol blocked the cysteine protease caspase-3 and subsequent cleavage of the DNA repair enzyme PARP.	Resveratrol	171-182	interleukin 1 beta	Homo sapiens	51-59
17959154-8	2008	Additionally, resveratrol reversed the IL-1beta-induced up-regulation of reactive oxygen species (ROS) in chondrocytes.	Resveratrol	14-25	interleukin 1 beta	Homo sapiens	39-47
18048764-8	2008	Thus, the cytokines IL-1beta and interferon-gamma, putative mediators of beta-cell loss in type 1 diabetes, induce severe ER stress through, respectively, NO-mediated depletion of ER calcium and inhibition of ER chaperones, thus hampering beta-cell defenses and amplifying the proapoptotic pathways.	Calcium	183-190	interleukin 1 beta	Homo sapiens	20-28
18230110-0	2008	Irsogladine maleate counters the interleukin-1 beta-induced suppression in gap-junctional intercellular communication but does not affect the interleukin-1 beta-induced zonula occludens protein-1 levels in human gingival epithelial cells.	irsogladine	0-19	interleukin 1 beta	Homo sapiens	33-51
18230110-4	2008	Furthermore, irsogladine maleate may affect the actions of interleukin-1 beta.	irsogladine	13-32	interleukin 1 beta	Homo sapiens	59-77
18230110-5	2008	In this study, we examined how interleukin-1 beta affected gap junctional intercellular communication, connexin 43 and zonula occludens protein-1, and how irsogladine maleate modulated the interleukin-1 beta-induced changes in the intercellular junctional complexes in human gingival epithelial cells.	irsogladine	155-174	interleukin 1 beta	Homo sapiens	189-207
18230110-11	2008	Irsogladine maleate countered the interleukin-1 beta-induced reduction in gap junctional intercellular communication and connexin 43 levels.	irsogladine	0-19	interleukin 1 beta	Homo sapiens	34-52
17991769-4	2008	Exposure to 1 ng/ml IL-1beta was first shown to markedly repress mRNA expression of sodium-taurocholate cotransporting polypeptide (NTCP), a major sinusoidal transporter handling bile acids, in both human hepatocytes and HepaRG cells.	Bile Acids and Salts	179-189	interleukin 1 beta	Homo sapiens	20-28
17920124-6	2008	The grouper IL-1beta was constitutively expressed in almost all tissues examined, and was augmented in PBL after the addition of LPS or Poly I:C in vitro.	Poly I-C	136-144	interleukin 1 beta	Homo sapiens	12-20
17920124-8	2008	Moreover, the rIL-1beta-induced IL-1beta and COX-2 expression were reduced by p38 MAPK inhibitor (SB203580) and JNK inhibitor (SP600125), respectively.	SB 203580	98-106	interleukin 1 beta	Homo sapiens	15-23
17920124-8	2008	Moreover, the rIL-1beta-induced IL-1beta and COX-2 expression were reduced by p38 MAPK inhibitor (SB203580) and JNK inhibitor (SP600125), respectively.	pyrazolanthrone	127-135	interleukin 1 beta	Homo sapiens	15-23
18205904-8	2008	Addition of IL-1beta (5 ng/ml) to a COGA-13 culture raised IL-6 production approximately thousandfold via a prostaglandin-independent mechanism.	Prostaglandins	108-121	interleukin 1 beta	Homo sapiens	12-20
17936042-6	2008	Pretreatment of cells with pitavastatin resulted in up-regulation of iNOS induction by IL-1beta, followed by increased NO production.	pitavastatin	27-39	interleukin 1 beta	Homo sapiens	87-95
18728809-1	2008	This study investigated the possible association of the interleukin-1 beta (IL-1beta) C-511T promoter polymorphism and the interleukin-1 receptor antagonist (IL-1Ra) (86bp)(n) variable number of tandem repeats (VNTR) polymorphism with antidepressant response to paroxetine and mirtazapine treatment.	Paroxetine	262-272	interleukin 1 beta	Homo sapiens	76-84
18728809-1	2008	This study investigated the possible association of the interleukin-1 beta (IL-1beta) C-511T promoter polymorphism and the interleukin-1 receptor antagonist (IL-1Ra) (86bp)(n) variable number of tandem repeats (VNTR) polymorphism with antidepressant response to paroxetine and mirtazapine treatment.	Mirtazapine	277-288	interleukin 1 beta	Homo sapiens	76-84
18728809-3	2008	Patients homozygous for the IL-1beta-511T allele had a significantly faster and more pronounced response to paroxetine treatment than IL-1beta-511C allele carriers.	Paroxetine	108-118	interleukin 1 beta	Homo sapiens	28-36
18728809-3	2008	Patients homozygous for the IL-1beta-511T allele had a significantly faster and more pronounced response to paroxetine treatment than IL-1beta-511C allele carriers.	Paroxetine	108-118	interleukin 1 beta	Homo sapiens	134-142
18728809-6	2008	Our results provide further suggestive evidence that time course of response and antidepressant efficacy of paroxetine, but not of mirtazapine, is influenced in a clinically relevant manner by the IL-1beta C-511T gene variant.	Paroxetine	108-118	interleukin 1 beta	Homo sapiens	197-205
18089587-1	2008	The purinergic receptor P2X(7) is activated by extracellular adenosine 5"-triphosphate (ATP) and promotes the efficient release of interleukin-1 beta.	Adenosine Triphosphate	61-86	interleukin 1 beta	Homo sapiens	131-149
18089587-4	2008	Costimulation of CBMCs in vitro with bacterial endotoxin and ATP resulted in significantly (P &lt; .05) enhanced interleukin-1 beta release in laboring (54.17 +/- 24.78 pg/mL(-1); n = 8) compared with nonlaboring (13.60 +/- 3.20 pg/mL(-1); n = 7) deliveries.	cbmcs	17-22	interleukin 1 beta	Homo sapiens	113-131
18089587-4	2008	Costimulation of CBMCs in vitro with bacterial endotoxin and ATP resulted in significantly (P &lt; .05) enhanced interleukin-1 beta release in laboring (54.17 +/- 24.78 pg/mL(-1); n = 8) compared with nonlaboring (13.60 +/- 3.20 pg/mL(-1); n = 7) deliveries.	Adenosine Triphosphate	61-64	interleukin 1 beta	Homo sapiens	113-131
18089587-5	2008	Release of interleukin-1 beta in both groups was blocked by preincubation with oxidized ATP, a P2X(7) receptor antagonist.	Adenosine Triphosphate	88-91	interleukin 1 beta	Homo sapiens	11-29
18296320-4	2008	Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory.	Fatty Acids, Omega-3	0-19	interleukin 1 beta	Homo sapiens	68-86
17485421-9	2008	When prostaglandin-E2 was added, in addition to IL-1beta+TNFalpha, proteoglycan release increased further, but proteoglycan synthesis was not influenced further.	Dinoprostone	5-21	interleukin 1 beta	Homo sapiens	48-56
17485421-10	2008	Addition of a selective COX-2 inhibitor to the IL-1beta+TNFalpha treated cartilage inhibited the enhanced prostaglandin-E2 production and almost completely normalised proteoglycan release, whereas synthesis remained unaffected.	Dinoprostone	106-122	interleukin 1 beta	Homo sapiens	47-55
17485421-14	2008	IL-1beta+TNFalpha induced NO seems to be involved in inhibition of proteoglycan synthesis, independent of prostaglandin-E2, and thus seems insensitive to regulation by (selective) COX-2 inhibitors.	Dinoprostone	106-122	interleukin 1 beta	Homo sapiens	0-8
18032781-7	2008	Furthermore, U46619 enhanced IL-1beta-induced THP-1 monocyte binding to VSMCs, which was inhibited by SQ29548 or SP600125.	SQ 29548	102-109	interleukin 1 beta	Homo sapiens	29-37
18032781-7	2008	Furthermore, U46619 enhanced IL-1beta-induced THP-1 monocyte binding to VSMCs, which was inhibited by SQ29548 or SP600125.	pyrazolanthrone	113-121	interleukin 1 beta	Homo sapiens	29-37
18163503-4	2008	METHODS: Human articular chondrocytes were treated with IL-1beta in the presence of TGFbeta1, pyrrolidine dithiocarbamate (a repressor of the NF-kappaB pathway), or cycloheximide.	pyrrolidine dithiocarbamic acid	94-121	interleukin 1 beta	Homo sapiens	56-64
18078749-1	2008	Analogues of the P2X(7) receptor antagonist KN-62, modified at the piperazine and arylsulfonyl groups, were synthesized and assayed at the human P2X(7) receptor for inhibition of BzATP-induced effects, that is, uptake of a fluorescent dye (ethidium bromide) in stably transfected HEK293 cells and IL-1beta release in differentiated THP-1 cells.	KN 62	44-49	interleukin 1 beta	Homo sapiens	297-305
18348730-0	2008	Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.	Sepharose	129-136	interleukin 1 beta	Homo sapiens	32-40
18348730-10	2008	RESULTS: IL-1beta activated the phosphorylation of p38 MAPK and this effect was abolished by SB203580.	SB 203580	93-101	interleukin 1 beta	Homo sapiens	9-17
18348730-11	2008	IL-1beta induced a transient increase in iNOS expression and stimulated the production of nitrite release.	Nitrites	90-97	interleukin 1 beta	Homo sapiens	0-8
18296320-4	2008	Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory.	Fatty Acids, Omega-3	0-19	interleukin 1 beta	Homo sapiens	88-97
18348730-12	2008	Stimulation by either dynamic compression or SB203580 in isolation reduced the IL-1beta induced iNOS expression and nitrite production.	SB 203580	45-53	interleukin 1 beta	Homo sapiens	79-87
18348730-12	2008	Stimulation by either dynamic compression or SB203580 in isolation reduced the IL-1beta induced iNOS expression and nitrite production.	Nitrites	116-123	interleukin 1 beta	Homo sapiens	79-87
19046432-8	2008	RESULTS: Rosiglitazone inhibited MMP-1 and MMP-13 expression in IL-1-beta-treated SW-1353 cells at the mRNA and heterogeneous nuclear RNA levels and blunted IL-1-beta-induced collagen destruction in vitro.	Rosiglitazone	9-22	interleukin 1 beta	Homo sapiens	157-166
18348730-14	2008	IL-1beta induced a transient increase in COX-2 expression and stimulated the cumulative production of PGE2 release.	Dinoprostone	102-106	interleukin 1 beta	Homo sapiens	0-8
19046432-1	2008	INTRODUCTION: We recently described the ability of retinoid X receptor (RXR) ligand LG100268 (LG268) to inhibit interleukin-1-beta (IL-1-beta)-driven matrix metalloproteinase-1 (MMP-1) and MMP-13 gene expression in SW-1353 chondrosarcoma cells.	LG 100268	84-92	interleukin 1 beta	Homo sapiens	112-130
19046432-1	2008	INTRODUCTION: We recently described the ability of retinoid X receptor (RXR) ligand LG100268 (LG268) to inhibit interleukin-1-beta (IL-1-beta)-driven matrix metalloproteinase-1 (MMP-1) and MMP-13 gene expression in SW-1353 chondrosarcoma cells.	LG 100268	84-92	interleukin 1 beta	Homo sapiens	132-141
19046432-4	2008	METHODS: We used real-time reverse transcription-polymerase chain reaction to measure LG268- and rosiglitazone-mediated inhibition of MMP gene transcription in IL-1-beta-treated SW-1353 chondrosarcoma cells.	LG 100268	86-91	interleukin 1 beta	Homo sapiens	160-169
17928629-10	2008	In cells transiently transfected with a luciferase reporter bearing a portion (-597/+33) of the human PTGES gene promoter, interleukin-1beta (IL1B) produced a moderate increase in luciferase activity; this effect was abrogated in the presence of an indirect NFkappaB inhibitor (MG-132).	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	278-284	interleukin 1 beta	Homo sapiens	123-140
19046432-4	2008	METHODS: We used real-time reverse transcription-polymerase chain reaction to measure LG268- and rosiglitazone-mediated inhibition of MMP gene transcription in IL-1-beta-treated SW-1353 chondrosarcoma cells.	Rosiglitazone	97-110	interleukin 1 beta	Homo sapiens	160-169
19046432-8	2008	RESULTS: Rosiglitazone inhibited MMP-1 and MMP-13 expression in IL-1-beta-treated SW-1353 cells at the mRNA and heterogeneous nuclear RNA levels and blunted IL-1-beta-induced collagen destruction in vitro.	Rosiglitazone	9-22	interleukin 1 beta	Homo sapiens	64-73
19094210-9	2008	Treatment of chondrocytes with IL-1beta upregulated L-PGDS mRNA and protein expressions as well as PGD2 production in a dose- and time-dependent manner.	Prostaglandin D2	99-103	interleukin 1 beta	Homo sapiens	31-39
19094210-10	2008	The upregulation of L-PGDS by IL-1beta was blocked by the translational inhibitor cycloheximide, indicating that this effect is indirect, requiring de novo protein synthesis.	Cycloheximide	82-95	interleukin 1 beta	Homo sapiens	30-38
19094210-13	2008	We also found that PGD2 prevented IL-1beta-induced upregulation of L-PGDS expression.	Prostaglandin D2	19-23	interleukin 1 beta	Homo sapiens	34-42
17928629-10	2008	In cells transiently transfected with a luciferase reporter bearing a portion (-597/+33) of the human PTGES gene promoter, interleukin-1beta (IL1B) produced a moderate increase in luciferase activity; this effect was abrogated in the presence of an indirect NFkappaB inhibitor (MG-132).	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	278-284	interleukin 1 beta	Homo sapiens	142-146
19478423-5	2008	Using data from a vitamin E intervention in elderly nursing home residents, we examined if the effect of vitamin E on ex vivo cytokine production of IL-1 beta, IL-6, TNF-alpha, and IFN-gamma depended on baseline cytokine production.	Vitamin E	105-114	interleukin 1 beta	Homo sapiens	149-158
18334727-4	2008	Diacerhein, in contrast to an NSAID, is a potent inhibitor of IL-1beta induced NO production by chondrocytes and cartilage.	diacerein	0-10	interleukin 1 beta	Homo sapiens	62-70
19075717-4	2008	We propose that ATP, released during neurotransmission, acting via purine P2 receptors on glia releases IL1 and TNF.	Adenosine Triphosphate	16-19	interleukin 1 beta	Homo sapiens	104-107
18836243-0	2008	In vitro inhibition of IL-1beta catabolic effects on cartilage: a mechanism involved on diacerein anti-OA properties.	diacerein	88-97	interleukin 1 beta	Homo sapiens	23-31
18281860-6	2008	Monosodium urate crystals stimulate IL-1beta secretion via cryopyrin, which led to the addition of gout to the spectrum of autoinflammatory diseases.	Uric Acid	0-16	interleukin 1 beta	Homo sapiens	36-44
18991693-3	2008	Following red wine (Negroamaro) pretreatment of lymphomonocytes, results will show a production of regulatory [Interleukin(IL)-12], proinflammatory (IL-1 beta and IL-6), and anti-inflammatory (IL-10) cytokines, as well as of IgA and IgG.	red wine	10-18	interleukin 1 beta	Homo sapiens	149-158
18472047-7	2008	Results showed that ATP decreased the rise in concentrations of TNF-alpha, interferon-gamma (IFN-gamma) and IL-1beta, but increased concentrations of IL-8 and IL-10.	Adenosine Triphosphate	20-23	interleukin 1 beta	Homo sapiens	108-116
19127062-6	2008	Furthermore, X-ALD lymphoblasts produced higher levels of nitric oxide (NO) and cytokines (tumor necrosis factor-alpha and interleukin 1 beta), and treatment with NaPA or lovastatin decreased the synthesis of NO.	Acecainide	163-167	interleukin 1 beta	Homo sapiens	123-141
19127062-6	2008	Furthermore, X-ALD lymphoblasts produced higher levels of nitric oxide (NO) and cytokines (tumor necrosis factor-alpha and interleukin 1 beta), and treatment with NaPA or lovastatin decreased the synthesis of NO.	Lovastatin	171-181	interleukin 1 beta	Homo sapiens	123-141
18063379-9	2008	CONCLUSIONS: IL-1beta and TNF-alpha upregulate mucin secretion from HMEEC in a dose- and time-dependant manner and these effects can be inhibited by cytokine blockade.	hmeec	68-73	interleukin 1 beta	Homo sapiens	13-21
17868967-4	2008	Furthermore, Cinnamaldehyde also inhibited the production of prointerleukin-1beta within LPS or LTA stimulated human THP-1 monocytes.	cinnamaldehyde	13-27	interleukin 1 beta	Homo sapiens	61-81
18389438-6	2008	Lycopene induced a dose-dependent increase in IL1beta, and TNFalpha production and a decrease in IL-2, IL-10 and IFNgamma secretion, whereas that of IL-6 and IL-1ra was not affected.	Lycopene	0-8	interleukin 1 beta	Homo sapiens	46-53
18444445-7	2008	RESULTS: The pattern of postoperative secretion of the proinflammatory cytokines IL-1beta and IL-6 and that of the anti-inflammatory cytokine IL-10 differed significantly between patients receiving SDFA and those receiving IDFA and LDFA, but was similar between the last two groups.	sdfa	198-202	interleukin 1 beta	Homo sapiens	81-89
18668392-0	2008	Thalidomide suppressed IL-1beta while enhancing TNF-alpha and IL-10, when cells in whole blood were stimulated with lipopolysaccharide.	Thalidomide	0-11	interleukin 1 beta	Homo sapiens	23-31
18668392-7	2008	Thalidomide suppressed interleukin 1 beta (IL-1beta) (p = 0.007), and it enhanced TNF-alpha (p = 0.007) and interleukin 10 (IL-10) (p = 0.031).	Thalidomide	0-11	interleukin 1 beta	Homo sapiens	23-41
18668392-7	2008	Thalidomide suppressed interleukin 1 beta (IL-1beta) (p = 0.007), and it enhanced TNF-alpha (p = 0.007) and interleukin 10 (IL-10) (p = 0.031).	Thalidomide	0-11	interleukin 1 beta	Homo sapiens	43-51
18668392-8	2008	Dexamethasone enhanced IL-10 (p = 0.013) and suppressed IL-1beta, TNF-alpha, interleukin 6 (IL-6), and interleukin 8 (IL-8) (p = 0.013).	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	56-64
17940116-10	2008	SB203580 suppressed TNF-alpha- and IL-1beta-induced MMP-1 and MMP-3 secretion by severalfold.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	35-43
18097066-0	2008	Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	26-34
18097066-3	2008	In this study, we examine the role of IL-1beta-mediated induction of cyclooxygenase-2 and PGE2, and evaluate the significance of individual E prostanoid (EP) receptors in mediating the fibroproliferative effects of IL-1beta in ALI.	Dinoprostone	90-94	interleukin 1 beta	Homo sapiens	38-46
18097066-4	2008	Blocking studies on human lung fibroblasts indicate that IL-1beta is the major cyclooxygenase-2 mRNA and PGE2-inducing factor in pulmonary edema fluid and accounts for the differential PGE2 induction noted in samples from ALI patients.	Dinoprostone	105-109	interleukin 1 beta	Homo sapiens	57-65
18097066-4	2008	Blocking studies on human lung fibroblasts indicate that IL-1beta is the major cyclooxygenase-2 mRNA and PGE2-inducing factor in pulmonary edema fluid and accounts for the differential PGE2 induction noted in samples from ALI patients.	Dinoprostone	185-189	interleukin 1 beta	Homo sapiens	57-65
18097066-5	2008	Surprisingly, we found that PGE2 produced by IL-1beta-stimulated fibroblasts enhances fibroblast proliferation.	Dinoprostone	28-32	interleukin 1 beta	Homo sapiens	45-53
17311056-1	2008	OBJECTIVE: To test whether breastfeeding"s protection against anorectic responses to infection is mediated by n-3 fatty acids" attenuation of interleukin (IL)-1beta and tumor necrosis factor (TNF)alpha.	Fatty Acids, Omega-3	110-125	interleukin 1 beta	Homo sapiens	142-164
17965029-6	2008	A significant inhibitory effect of besifloxacin was observed at 0.1 mg/L for IL-1alpha, at 1 mg/L for G-CSF, IL-1ra and IL-6 and at 30 mg/L for GM-CSF, IL-12p40, IL-1beta, IL-8, IP-10, MCP-1 and MIP-1alpha.	besifloxacin	35-47	interleukin 1 beta	Homo sapiens	162-170
17541958-5	2008	Results showed that CS initially delayed the production of "innate" cytokines (e.g., IL-1beta and IL-6) and reduced glutathione levels.	Cesium	20-22	interleukin 1 beta	Homo sapiens	85-93
17976731-8	2008	Expression of mRNAs for IL-1 beta, IFN-gamma, and IL-10 decreased at day 2-7 of doxycycline treatment.	Doxycycline	80-91	interleukin 1 beta	Homo sapiens	24-33
17934698-1	2008	Culturing hepatocytes with a combination of LPS, TNF-alpha, IL-1beta and IFN-gamma resulted in an inhibition of glucose output from glycogen and prevented the repletion of glycogen in freshly cultured cells.	Glucose	112-119	interleukin 1 beta	Homo sapiens	60-68
18824875-0	2008	Nitric oxide involvement in TNF-alpha and IL-1 beta-mediated changes in human mesangial cell MMP-9 and TIMP-1.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	42-51
18824875-3	2008	Therefore we examined the potential role of nitric oxide (NO) in the regulation of MMP-9 and TIMP-1 by tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) using the human mesangial cell line (HMCL).	Nitric Oxide	44-56	interleukin 1 beta	Homo sapiens	168-177
18427719-0	2008	Hyaluronan inhibits IL-1beta-stimulated collagenase production via down-regulation of phosphorylated p38 in SW-1353 human chondrosarcoma cells.	Hyaluronic Acid	0-10	interleukin 1 beta	Homo sapiens	20-28
18427719-1	2008	We investigated the intracellular mechanism for the inhibitory effects of hyaluronan (HA) on interleukin-1beta (IL-1beta)-stimulated collagenase-1 and -3 (matrix metalloproteinases (MMPs)-1 and -13) production in a human chondrosarcoma cell line, SW-1353.	Hyaluronic Acid	74-84	interleukin 1 beta	Homo sapiens	93-110
18427719-1	2008	We investigated the intracellular mechanism for the inhibitory effects of hyaluronan (HA) on interleukin-1beta (IL-1beta)-stimulated collagenase-1 and -3 (matrix metalloproteinases (MMPs)-1 and -13) production in a human chondrosarcoma cell line, SW-1353.	Hyaluronic Acid	74-84	interleukin 1 beta	Homo sapiens	112-120
18427719-5	2008	SB203580, a p38 MAPK inhibitor, partially blocked the MMP-1 and -13 production stimulated by IL-1beta.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	93-101
17934698-1	2008	Culturing hepatocytes with a combination of LPS, TNF-alpha, IL-1beta and IFN-gamma resulted in an inhibition of glucose output from glycogen and prevented the repletion of glycogen in freshly cultured cells.	Glycogen	132-140	interleukin 1 beta	Homo sapiens	60-68
17934698-1	2008	Culturing hepatocytes with a combination of LPS, TNF-alpha, IL-1beta and IFN-gamma resulted in an inhibition of glucose output from glycogen and prevented the repletion of glycogen in freshly cultured cells.	Glycogen	172-180	interleukin 1 beta	Homo sapiens	60-68
18846238-3	2008	The mechanism by which this occurs is not fully understood, but normal IL-1beta mediated activation of the production of these cytokines occurs via H2O2 dependent signaling.	Hydrogen Peroxide	148-152	interleukin 1 beta	Homo sapiens	71-79
17889545-1	2007	5-Arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones (7,8) were synthesized and evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1beta.	5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones	0-58	interleukin 1 beta	Homo sapiens	176-184
18946510-6	2008	Applying a whole blood assay, IC(50) values of pro-inflammatory cytokine release (TNF-alpha, IL-6, IL-8, IL-1beta) were found to be positively correlated with the K(i)-values of the aforementioned polyphenols.	Polyphenols	197-208	interleukin 1 beta	Homo sapiens	105-113
17913526-11	2008	iNOS promoter activity induced by IL-1beta was inhibited by dexamethasone and the inhibitory effect was reversed by HDAC inhibitor trichostatin A.	Dexamethasone	60-73	interleukin 1 beta	Homo sapiens	34-42
17913526-11	2008	iNOS promoter activity induced by IL-1beta was inhibited by dexamethasone and the inhibitory effect was reversed by HDAC inhibitor trichostatin A.	trichostatin A	131-145	interleukin 1 beta	Homo sapiens	34-42
17963696-5	2007	3-Methylcholanthrene (a potent AhR agonist) increased the expression (mRNA) of the major inflammatory targets IL-1beta and MMP9.	Methylcholanthrene	0-20	interleukin 1 beta	Homo sapiens	110-118
18540202-1	2008	The aim of the present study was to estimate the absorption of 125I-labeled proinflammatory cytokines--interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) from inflamed porcine uterus into the uterine venous blood.	Iodine-125	63-67	interleukin 1 beta	Homo sapiens	122-130
18295521-5	2008	Activation of the monocyte ETB subtype by ET (1 ng/ml) concentration-dependently stimulated TNF-alpha (744%) &gt;PGE2 (570%) &gt; IL-1 beta (112%) and had no effect on 5-lipoxygenase metabolism.	Dinoprostone	113-117	interleukin 1 beta	Homo sapiens	130-139
18295521-6	2008	Compared with ET a different profile of IL-1 beta &gt;TNF-alpha &gt;PGE2 was induced by LPS.	Dinoprostone	68-72	interleukin 1 beta	Homo sapiens	40-49
18167199-11	2007	However, interleukin 1 beta (IL-1 beta) further increased intracellular cholesterol level in the presence of LDL by increasing both LDL receptor mRNA and protein expression in HepG2.	Cholesterol	72-83	interleukin 1 beta	Homo sapiens	9-27
18167199-11	2007	However, interleukin 1 beta (IL-1 beta) further increased intracellular cholesterol level in the presence of LDL by increasing both LDL receptor mRNA and protein expression in HepG2.	Cholesterol	72-83	interleukin 1 beta	Homo sapiens	29-38
18167199-14	2007	CONCLUSIONS: IL-1 beta disrupts cholesterol-mediated LDL receptor feedback regulation by enhancing SCAP-SREBP complex translocation from the ER to the Golgi, thereby increasing SREBP-2 mediated LDL receptor expression even in the presence of high concentration of LDL.	Cholesterol	32-43	interleukin 1 beta	Homo sapiens	13-22
17889545-4	2007	Several thiazolidinones 7 and 8 exhibited the ability to block the production or action of the degenerative factors induced by IL-1beta.	THIAZOLIDINONES	8-23	interleukin 1 beta	Homo sapiens	127-135
17988083-1	2007	The target for the anti-inflammatory natural products like amentoflavone ( 2), which act by interfering with the proinflammatory cytokine pathway (e.g., TNF-alpha, IL-1beta, and NO synthase), is not yet well-defined.	amentoflavone	59-72	interleukin 1 beta	Homo sapiens	164-172
18032608-7	2007	We found that pretreatment with muramyl dipeptide (MDP), a ligand for Nod2, significantly decreased production of the proinflammatory cytokines TNF-alpha, IL-8, and IL-1beta upon Nod2, TLR4, and TLR2 restimulation in primary human monocyte-derived macrophages from a large cohort of individuals.	Acetylmuramyl-Alanyl-Isoglutamine	32-49	interleukin 1 beta	Homo sapiens	165-173
17920534-0	2007	Bucillamine mechanism inhibiting IL-1beta-induced VEGF production from fibroblast-like synoviocytes.	bucillamine	0-11	interleukin 1 beta	Homo sapiens	33-41
17920534-1	2007	We investigated the bucillamine (Buc) mechanism inhibiting interleukin (IL)-1beta-induced vascular endothelial growth factor (VEGF) production from human fibroblast-like synoviocytes (HFLS) which derived from the inflamed synovium of an RA patient using SA981, its active metabolite.	bucillamine	20-31	interleukin 1 beta	Homo sapiens	59-81
17920534-1	2007	We investigated the bucillamine (Buc) mechanism inhibiting interleukin (IL)-1beta-induced vascular endothelial growth factor (VEGF) production from human fibroblast-like synoviocytes (HFLS) which derived from the inflamed synovium of an RA patient using SA981, its active metabolite.	bucillamine	33-36	interleukin 1 beta	Homo sapiens	59-81
17920534-3	2007	While SA981 partially inhibited IL-1beta-induced VEGF production at concentrations of 10 to 100 microM (10.1% and 14.2% inhibition of total VEGF production under IL-1beta coexistence condition, respectively), it failed to inhibit IL-1beta-induced IL-6 production at the same concentrations.	bucillamine disulfide	6-11	interleukin 1 beta	Homo sapiens	32-40
17920534-3	2007	While SA981 partially inhibited IL-1beta-induced VEGF production at concentrations of 10 to 100 microM (10.1% and 14.2% inhibition of total VEGF production under IL-1beta coexistence condition, respectively), it failed to inhibit IL-1beta-induced IL-6 production at the same concentrations.	bucillamine disulfide	6-11	interleukin 1 beta	Homo sapiens	162-170
17920534-3	2007	While SA981 partially inhibited IL-1beta-induced VEGF production at concentrations of 10 to 100 microM (10.1% and 14.2% inhibition of total VEGF production under IL-1beta coexistence condition, respectively), it failed to inhibit IL-1beta-induced IL-6 production at the same concentrations.	bucillamine disulfide	6-11	interleukin 1 beta	Homo sapiens	162-170
17920534-5	2007	SA981 at a concentration of 100 microM partially inhibited IL-1beta-induced phosphorylation of p38MAPK and Akt (12.0% and 36.1% inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition, respectively).	bucillamine disulfide	0-5	interleukin 1 beta	Homo sapiens	59-67
17920534-5	2007	SA981 at a concentration of 100 microM partially inhibited IL-1beta-induced phosphorylation of p38MAPK and Akt (12.0% and 36.1% inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition, respectively).	bucillamine disulfide	0-5	interleukin 1 beta	Homo sapiens	184-192
17920534-9	2007	These results suggest that SA981 partially inhibits VEGF production via modifications on IL-1beta signaling.	bucillamine disulfide	27-32	interleukin 1 beta	Homo sapiens	89-97
18202522-8	2007	The IL-1beta-stimulated uPA mRNA expression and PA activities in the cell lysate and medium were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrolidinedithiocarbamate, and were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate.	herbimycin	139-151	interleukin 1 beta	Homo sapiens	4-12
18202522-8	2007	The IL-1beta-stimulated uPA mRNA expression and PA activities in the cell lysate and medium were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrolidinedithiocarbamate, and were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate.	Genistein	156-165	interleukin 1 beta	Homo sapiens	4-12
18202522-8	2007	The IL-1beta-stimulated uPA mRNA expression and PA activities in the cell lysate and medium were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrolidinedithiocarbamate, and were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate.	pyrolidinedithiocarbamate	197-222	interleukin 1 beta	Homo sapiens	4-12
18202522-8	2007	The IL-1beta-stimulated uPA mRNA expression and PA activities in the cell lysate and medium were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrolidinedithiocarbamate, and were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate.	Sodium orthovanadate	281-301	interleukin 1 beta	Homo sapiens	4-12
18202522-9	2007	These observations suggest that IL-1beta stimulates uPA production via activation of NFkappaB and tyrosine phosphorylation, and also secretion of the enzyme, and that the uPA/plasmin system appears to be involved in inflammation in human dental pulp.	Tyrosine	98-106	interleukin 1 beta	Homo sapiens	32-40
17714972-11	2007	Urate monosodium crystals are specifically detected via the NALP3 inflammasome, which results in marked IL-1beta overproduction and initiation of an inflammatory response.	Uric Acid	0-5	interleukin 1 beta	Homo sapiens	104-112
18186699-0	2007	Association of interleukin-1beta gene and receptor antagonist polymorphisms with calcium oxalate urolithiasis.	Calcium Oxalate	81-96	interleukin 1 beta	Homo sapiens	15-32
18090474-0	2007	Hyaluronan suppresses IL-1beta-induced metalloproteinase activity from synovial tissue.	Hyaluronic Acid	0-10	interleukin 1 beta	Homo sapiens	22-30
18090474-3	2007	We tested the hypothesis that hyaluronan inhibited interleukin-1beta-induced matrix metalloproteinase activity secreted by explants of synovial tissue from patients with osteoarthritis and investigated the mechanism of the effect.	Hyaluronic Acid	30-40	interleukin 1 beta	Homo sapiens	51-68
18090474-8	2007	Hyaluronan inhibited interleukin-1beta-induced metalloproteinase production from osteoarthritic synovial tissue by a process that was not solely dependent on hyaluronan molecular mass but that was partly mediated by hyaluronan binding to CD44.	Hyaluronic Acid	0-10	interleukin 1 beta	Homo sapiens	21-38
18090474-8	2007	Hyaluronan inhibited interleukin-1beta-induced metalloproteinase production from osteoarthritic synovial tissue by a process that was not solely dependent on hyaluronan molecular mass but that was partly mediated by hyaluronan binding to CD44.	Hyaluronic Acid	158-168	interleukin 1 beta	Homo sapiens	21-38
18090474-8	2007	Hyaluronan inhibited interleukin-1beta-induced metalloproteinase production from osteoarthritic synovial tissue by a process that was not solely dependent on hyaluronan molecular mass but that was partly mediated by hyaluronan binding to CD44.	Hyaluronic Acid	216-226	interleukin 1 beta	Homo sapiens	21-38
18184040-2	2007	Here, we demonstrate that nontoxic concentrations of zinc (15 muM), employed as zinc chloride (ZnCl(2)), that are about 2-fold of the readily accessible pool of albumin-bound zinc in the plasma, strongly enhance the potential of interleukin-1beta (IL-1beta) to act as an IFN-gamma-inducing factor on PBMCs.	zinc chloride	80-93	interleukin 1 beta	Homo sapiens	229-246
18184040-2	2007	Here, we demonstrate that nontoxic concentrations of zinc (15 muM), employed as zinc chloride (ZnCl(2)), that are about 2-fold of the readily accessible pool of albumin-bound zinc in the plasma, strongly enhance the potential of interleukin-1beta (IL-1beta) to act as an IFN-gamma-inducing factor on PBMCs.	zinc chloride	80-93	interleukin 1 beta	Homo sapiens	248-256
18184040-2	2007	Here, we demonstrate that nontoxic concentrations of zinc (15 muM), employed as zinc chloride (ZnCl(2)), that are about 2-fold of the readily accessible pool of albumin-bound zinc in the plasma, strongly enhance the potential of interleukin-1beta (IL-1beta) to act as an IFN-gamma-inducing factor on PBMCs.	zncl	95-99	interleukin 1 beta	Homo sapiens	229-246
18184040-2	2007	Here, we demonstrate that nontoxic concentrations of zinc (15 muM), employed as zinc chloride (ZnCl(2)), that are about 2-fold of the readily accessible pool of albumin-bound zinc in the plasma, strongly enhance the potential of interleukin-1beta (IL-1beta) to act as an IFN-gamma-inducing factor on PBMCs.	zncl	95-99	interleukin 1 beta	Homo sapiens	248-256
17714972-11	2007	Urate monosodium crystals are specifically detected via the NALP3 inflammasome, which results in marked IL-1beta overproduction and initiation of an inflammatory response.	Sodium	6-16	interleukin 1 beta	Homo sapiens	104-112
17604656-4	2007	The aim of this study was to determine whether the modulation of the response of articular chondrocytes to TGF-beta by IL-1beta or TNF-alpha signaling pathways occurs through regulation of activity and availability of mothers against DPP (Drosophila) human homologue (Smad) proteins.	dipalmitoylphosphatidylserine	234-237	interleukin 1 beta	Homo sapiens	119-127
17963373-0	2007	Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.	Adamantane	34-44	interleukin 1 beta	Homo sapiens	94-111
18240548-4	2007	The onset of premature labor in the context of infection is mediated by pro-inflammatory cytokines, such as interleukin (IL)-1beta and tumor necrosis factor alpha (TNF-alpha), as these cytokines are produced by intrauterine tissues in response to microbial products, can stimulate prostaglandin production, and induce labor in animals.	Prostaglandins	281-294	interleukin 1 beta	Homo sapiens	108-130
17561367-5	2007	SR was more potent than syringin and isofraxidin at inhibiting the expression of IL-1beta, IL-6, cyclooxygenase (COX)-2 and matrix metalloproteinases (MMP)-1 mRNA, but was less potent than syringin at inhibiting the expression of MMP-2.	Strontium	0-2	interleukin 1 beta	Homo sapiens	81-89
17561367-5	2007	SR was more potent than syringin and isofraxidin at inhibiting the expression of IL-1beta, IL-6, cyclooxygenase (COX)-2 and matrix metalloproteinases (MMP)-1 mRNA, but was less potent than syringin at inhibiting the expression of MMP-2.	isofraxidin	37-48	interleukin 1 beta	Homo sapiens	81-89
17720209-11	2007	Preincubation with intracellular calcium chelator (BAPTA-AM) attenuated IL-1beta and IL-8 production, but not GM-CSF and LIF production.	Calcium	33-40	interleukin 1 beta	Homo sapiens	72-80
17720209-11	2007	Preincubation with intracellular calcium chelator (BAPTA-AM) attenuated IL-1beta and IL-8 production, but not GM-CSF and LIF production.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	51-59	interleukin 1 beta	Homo sapiens	72-80
17720209-13	2007	Our results also suggest that PM(10) induces the production of pro-inflammatory mediators via either intracellular calcium-dependent (IL-1beta, IL-8) or -independent (GM-CSF, LIF) pathways.	Calcium	115-122	interleukin 1 beta	Homo sapiens	134-142
18039391-0	2007	Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway.	baicalein	0-9	interleukin 1 beta	Homo sapiens	19-27
17982107-3	2007	In this study, we report that the induction of PGHS-2 by IL-1beta is dramatically enhanced and prolonged when Jak2 signaling is abrogated, either with the specific inhibitor AG490 or by transiently transfecting fibroblasts with a dominant negative mutant Jak2.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	174-179	interleukin 1 beta	Homo sapiens	57-65
17982107-5	2007	Surprisingly, interrupting Jak2 function also blocked the expected increase in PGE(2) synthesis usually provoked by IL-1beta.	Dinoprostone	79-85	interleukin 1 beta	Homo sapiens	116-124
17923111-4	2007	By knock down of LPA1 and LPA3 in HUVECs, LPA-enhanced IL-1beta mRNA expression was significantly attenuated.	lysophosphatidic acid	17-20	interleukin 1 beta	Homo sapiens	55-63
17982107-6	2007	This resulted from the rapid loss of IL-1beta-dependent arachidonate release and by attenuation of group IIA secreted PLA(2) (sPLA(2)) gene induction.	Arachidonic Acid	56-68	interleukin 1 beta	Homo sapiens	37-45
17923111-5	2007	Moreover, LPA1 and LPA3 siRNA also inhibited LPA-enhanced IL-1-dependent long-term IL-8 and MCP-1 mRNA expression, and subsequent THP-1 cell chemotaxis toward LPA-treated HUVEC-conditioned media.	lysophosphatidic acid	10-13	interleukin 1 beta	Homo sapiens	58-62
17923111-5	2007	Moreover, LPA1 and LPA3 siRNA also inhibited LPA-enhanced IL-1-dependent long-term IL-8 and MCP-1 mRNA expression, and subsequent THP-1 cell chemotaxis toward LPA-treated HUVEC-conditioned media.	lysophosphatidic acid	19-22	interleukin 1 beta	Homo sapiens	58-62
17982107-9	2007	sPLA(2) expression following transfection resulted in increased IL-1beta-dependent PGHS-2 and microsomal PGE(2) synthase levels.	Prostaglandins E	105-108	interleukin 1 beta	Homo sapiens	64-72
17982107-12	2007	Moreover, it is required for IL-1beta-dependent signaling to sPLA(2), the expression and activity of which are necessary for up-regulating PGE(2) synthesis in orbital fibroblasts.	Prostaglandins E	139-142	interleukin 1 beta	Homo sapiens	29-37
17868064-9	2007	Diannexin treatment decreased TNF-alpha, IL-1beta, IP-10 expression, diminished expression of P-selectin, endothelial ICAM-1, and attenuated OLT infiltration by macrophages, CD4 cells and PMNs.	diannexin	0-9	interleukin 1 beta	Homo sapiens	41-49
17934097-8	2007	K(D)PT, a derivative of KPV corresponding to the amino acid 193-195 of IL-1beta, is currently emerging as another tripeptide with potent anti-inflammatory effects.	Platinum	4-6	interleukin 1 beta	Homo sapiens	71-79
17934097-8	2007	K(D)PT, a derivative of KPV corresponding to the amino acid 193-195 of IL-1beta, is currently emerging as another tripeptide with potent anti-inflammatory effects.	tripeptide K-26	114-124	interleukin 1 beta	Homo sapiens	71-79
17949278-3	2007	MCP-1 secretion and mRNA expression and transcription activity stimulated by TNF-alpha or IL-1beta were significantly inhibited by 1% DMSO in alveolar type II epithelial cells (A549).	Dimethyl Sulfoxide	134-138	interleukin 1 beta	Homo sapiens	90-98
17988365-4	2007	RESULTS: Monocytes stimulated by LPS from non-lithium-treated bipolar patients were characterized by an abnormal IL-1beta/IL-6 production ratio, i.e., low IL-1beta and high IL-6 production.	Lithium	46-53	interleukin 1 beta	Homo sapiens	113-121
17988365-5	2007	Lithium treatment increased IL-1beta and decreased IL-6 production and thus restored the aberrant ratio.	Lithium	0-7	interleukin 1 beta	Homo sapiens	28-36
17988365-0	2007	An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment.	Lithium	101-108	interleukin 1 beta	Homo sapiens	34-42
17988365-6	2007	In vitro exposure of monocytes to LiCl did not have the same effects as lithium treatment: the procedure decreased IL-1beta production and had minimal effects on IL-6 production.	Lithium Chloride	34-38	interleukin 1 beta	Homo sapiens	115-123
17947694-3	2007	Recently, we demonstrated the ability of EPs to favor a Th1 cytokine (IL-2, IFN-gamma) cell response in lymphocytes and to regulate IL-1beta expression in melanoma cells.	eps	41-44	interleukin 1 beta	Homo sapiens	132-140
17916353-7	2007	Furthermore, levels of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), were significantly decreased with rolipram treatment.	Rolipram	163-171	interleukin 1 beta	Homo sapiens	55-72
17916353-7	2007	Furthermore, levels of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), were significantly decreased with rolipram treatment.	Rolipram	163-171	interleukin 1 beta	Homo sapiens	74-82
17636564-7	2007	LPS-induced IL-1beta production was inhibited by certolizumab pegol, infliximab, and adalimumab, but only partially inhibited by etanercept.	Certolizumab Pegol	49-67	interleukin 1 beta	Homo sapiens	12-20
17636564-9	2007	As certolizumab pegol, infliximab, and adalimumab, but not etanercept, almost completely inhibited LPS-induced IL-1beta release from monocytes, inhibition of cytokine production may be important for efficacy of anti-TNFalpha agents in CD.	Certolizumab Pegol	3-15	interleukin 1 beta	Homo sapiens	111-119
17296257-0	2007	Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells.	trichostatin A	52-66	interleukin 1 beta	Homo sapiens	15-23
17296257-0	2007	Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells.	trichostatin A	68-71	interleukin 1 beta	Homo sapiens	15-23
17296257-7	2007	CONCLUSIONS: TSA suppresses IL-1beta-induced COX-2 gene and protein expression in endometrial stromal cells.	trichostatin A	13-16	interleukin 1 beta	Homo sapiens	28-36
17959904-1	2007	The purpose of this study was to clarify the main contributory factor of nifedipine-induced gingival overgrowth either by Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) or interleukin-1beta (IL-1beta).	Nifedipine	73-83	interleukin 1 beta	Homo sapiens	197-205
17959904-4	2007	Among the three stimulants--IL-1beta, Pg-LPS, and Ec-LPS--androgen receptor and IL-6 gene expressions in both the healthy and nifedipine-induced gingival overgrowth groups were strongly up-regulated by the presence of IL-1beta only.	Nifedipine	126-136	interleukin 1 beta	Homo sapiens	28-36
17959904-4	2007	Among the three stimulants--IL-1beta, Pg-LPS, and Ec-LPS--androgen receptor and IL-6 gene expressions in both the healthy and nifedipine-induced gingival overgrowth groups were strongly up-regulated by the presence of IL-1beta only.	Nifedipine	126-136	interleukin 1 beta	Homo sapiens	218-226
17959904-5	2007	Furthermore, the responses to IL-1beta in the nifedipine-induced gingival overgrowth group were stronger than those of the healthy group.	Nifedipine	46-56	interleukin 1 beta	Homo sapiens	30-38
17959904-6	2007	It can be concluded that IL-1beta is an important mediator responsible for the higher IL-6 and androgen receptor expression of nifedipine-induced gingival overgrowth cells.	Nifedipine	127-137	interleukin 1 beta	Homo sapiens	25-33
17947694-6	2007	We evidenced that EPs down-regulated both at the mRNA and protein levels the proinflammatory TNF-alpha, IL-1beta, and IL-6 expression in LPS-activated monocytes.	eps	18-21	interleukin 1 beta	Homo sapiens	104-112
17707523-4	2007	The cytokines TNFalpha and IL-1beta increased protein expression and activity of mPGES-1, accompanied by increased COX-2 expression and PGE2 production.	Dinoprostone	136-140	interleukin 1 beta	Homo sapiens	27-35
17989609-5	2007	RESULTS: Sirolimus inhibited low-density lipoprotein (LDL) receptor (LDLr)-mediated cholesterol ester accumulation induced by interleukin-1beta in HepG2 cells.	Sirolimus	9-18	interleukin 1 beta	Homo sapiens	126-143
17989609-5	2007	RESULTS: Sirolimus inhibited low-density lipoprotein (LDL) receptor (LDLr)-mediated cholesterol ester accumulation induced by interleukin-1beta in HepG2 cells.	Cholesterol Esters	84-101	interleukin 1 beta	Homo sapiens	126-143
17590158-5	2007	RESULTS: Activation of PRPs with calcium and thrombin triggered an immediate release of VEGF, PDGF-BB and TGF-beta and a delayed release of IL-1beta in PRP supernatants.	Calcium	33-40	interleukin 1 beta	Homo sapiens	140-148
17681970-3	2007	We have assessed the effect of preoperative administration of a sub-anaesthetic dose of ketamine on the mitogen response and production of interleukin (IL)-1beta, IL-2, IL-6, and tumour necrosis factor (TNF)-alpha by peripheral blood mononuclear cells (PBMCs), as well as natural killer cell cytotoxicity (NKCC) in patients undergoing abdominal surgery.	Ketamine	88-96	interleukin 1 beta	Homo sapiens	139-161
17631285-4	2007	METHODS AND RESULTS: Using Northern- and Western-blot analyses, we documented that interleukin-1beta (IL-1beta) induced Id2 gene expression in VSMC in a time- and dose-dependent manner.	vsmc	143-147	interleukin 1 beta	Homo sapiens	83-100
17631285-4	2007	METHODS AND RESULTS: Using Northern- and Western-blot analyses, we documented that interleukin-1beta (IL-1beta) induced Id2 gene expression in VSMC in a time- and dose-dependent manner.	vsmc	143-147	interleukin 1 beta	Homo sapiens	102-110
17645739-0	2007	Dexamethasone suppresses interleukin-1beta-induced human beta-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-kappaB transcriptional factor in A549 cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	25-42
17394066-4	2007	Preincubation of the mesothelial monolayer with IL-1beta or TNF-alpha resulted in enhanced tumor cell adhesion of Caco2 and HT29 colon carcinoma cells.	mesothelial	21-32	interleukin 1 beta	Homo sapiens	48-56
17640998-2	2007	Our previous studies have demonstrated that normal primary thyroid epithelial cells are resistant to Fas-mediated apoptosis, but the resistance can be overcome by pretreatment with a combination of interferon-gamma (IFN-gamma) and IL-1beta.	ammonium ferrous sulfate	101-104	interleukin 1 beta	Homo sapiens	231-239
17640998-6	2007	Furthermore, the sensitization of primary thyroid epithelial cells to Fas-mediated apoptosis by IFN-gamma/IL-1beta was significantly blocked by a general caspase inhibitor, z-VAD, or by the combination of two specific individual caspase inhibitors.	ammonium ferrous sulfate	70-73	interleukin 1 beta	Homo sapiens	106-114
17640998-6	2007	Furthermore, the sensitization of primary thyroid epithelial cells to Fas-mediated apoptosis by IFN-gamma/IL-1beta was significantly blocked by a general caspase inhibitor, z-VAD, or by the combination of two specific individual caspase inhibitors.	z-vad	173-178	interleukin 1 beta	Homo sapiens	106-114
17640998-7	2007	In addition, our results showed that IFN-gamma/IL-1beta enhance p38 MAPK phosphorylation and that SB 203580, a p38 MAPK inhibitor, can inhibit IFN-gamma/IL-1beta-induced p38 MAPK phosphorylation.	SB 203580	98-107	interleukin 1 beta	Homo sapiens	153-161
17640998-8	2007	SB 203580 also significantly prevented cytokine-induced iNOS expression and caspase activation and thus blocked Fas-mediated apoptosis of thyroid cells sensitized by IFN-gamma/IL-1beta.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	176-184
17640998-9	2007	In conclusion, our data suggest that both p38 MAPK and iNOS are involved in IFN-gamma/IL-1beta-induced sensitization of the thyroid cells to Fas-mediated apoptosis via the activation of caspases 3, 7, and 10 and that this pathway may be further activated by BID.	ammonium ferrous sulfate	141-144	interleukin 1 beta	Homo sapiens	86-94
17765224-3	2007	We investigated if pro-inflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma), induce ROS in human retinal pigment epithelial (RPE) cells.	Reactive Oxygen Species	155-158	interleukin 1 beta	Homo sapiens	82-100
17645739-4	2007	In this study, we further investigated whether dexamethasone (Dex) controls IL-1beta-induced HBD-2 mRNA expression in A549 cells and the molecular mechanism associated with it.	Dexamethasone	47-60	interleukin 1 beta	Homo sapiens	76-84
17645739-4	2007	In this study, we further investigated whether dexamethasone (Dex) controls IL-1beta-induced HBD-2 mRNA expression in A549 cells and the molecular mechanism associated with it.	Dexamethasone	62-65	interleukin 1 beta	Homo sapiens	76-84
17765224-3	2007	We investigated if pro-inflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma), induce ROS in human retinal pigment epithelial (RPE) cells.	Reactive Oxygen Species	155-158	interleukin 1 beta	Homo sapiens	102-111
17765224-4	2007	TNF-alpha, IL-1 beta and IFN-gamma increased both intracellular and extracellular ROS production in a time- and dose-dependent manner.	Reactive Oxygen Species	82-85	interleukin 1 beta	Homo sapiens	11-20
17645739-5	2007	Dex suppressed IL-1beta-induced HBD-2 mRNA expression, which is mediated by a glucocorticoid receptor, at the transcriptional level.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	15-23
17645739-6	2007	Interestingly, Dex attenuated IL-1beta-mediated activation of p38 MAPK and JNK, but not of AKT.	Dexamethasone	15-18	interleukin 1 beta	Homo sapiens	30-38
17765224-6	2007	NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines.	diphenylene iodinium	25-45	interleukin 1 beta	Homo sapiens	87-96
17765224-6	2007	NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines.	hexose monophosphate	188-208	interleukin 1 beta	Homo sapiens	87-96
17765224-6	2007	NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines.	Reactive Oxygen Species	61-64	interleukin 1 beta	Homo sapiens	87-96
17765224-6	2007	NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines.	Reactive Oxygen Species	256-259	interleukin 1 beta	Homo sapiens	87-96
17645739-7	2007	Dex increased the expression of MAPK phosphatase (MKP)-1, which dephosphorylated p38 MAPK, but not JNK, by IL-1beta.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	107-115
17645739-9	2007	These results suggest that Dex acts to inhibit IL-1beta-induced HBD-2 mRNA expression through blockage of the nuclear transcriptional activation of p65 NF-kappaB as well as through inactivation of p38 MAPK and JNK.	Dexamethasone	27-30	interleukin 1 beta	Homo sapiens	47-55
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P&lt;0.05).	Reactive Oxygen Species	0-3	interleukin 1 beta	Homo sapiens	127-136
17645739-10	2007	Specifically, Dex-induced MKP-1 expression is responsible for the inactivation of p38 MAPK, but not JNK, in response to IL-1beta in A549 cells.	Dexamethasone	14-17	interleukin 1 beta	Homo sapiens	120-128
17892496-1	2007	We previously demonstrated that the expression of the argininosuccinate synthetase (ASS) gene, a key step in nitric oxide production, is stimulated either by interleukin-1beta[Brasse-Lagnel et al.	Nitric Oxide	109-121	interleukin 1 beta	Homo sapiens	158-175
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P&lt;0.05).	pyrrolidine dithiocarbamic acid	16-42	interleukin 1 beta	Homo sapiens	127-136
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P&lt;0.05).	pyrrolidine dithiocarbamic acid	44-48	interleukin 1 beta	Homo sapiens	127-136
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P&lt;0.05).	Acetylcysteine	54-71	interleukin 1 beta	Homo sapiens	127-136
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P&lt;0.05).	Acetylcysteine	73-76	interleukin 1 beta	Homo sapiens	127-136
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P&lt;0.05).	Reactive Oxygen Species	101-104	interleukin 1 beta	Homo sapiens	127-136
17765224-8	2007	Collectively, these results demonstrate that TNF-alpha, IL-1 beta and IFN-gamma increase mitochondrial- and NADPH oxidase-generated ROS in human RPE cells.	Reactive Oxygen Species	132-135	interleukin 1 beta	Homo sapiens	56-65
18026701-0	2007	Evaluation of the suppressive actions of glucosamine on the interleukin-1beta-mediated activation of synoviocytes.	Glucosamine	41-52	interleukin 1 beta	Homo sapiens	60-77
18026701-3	2007	MATERIALS AND METHODS: Synoviocytes isolated from human synovial tissues were stimulated with interleukin (IL)-1beta in the presence of 0.01-1 mM glucosamine.	Glucosamine	146-157	interleukin 1 beta	Homo sapiens	94-116
18026701-7	2007	RESULTS: Glucosamine significantly suppressed the IL-1beta-induced IL-8 production as well as its mRNA expression (p &lt; 0.05) at 1 mM.	Glucosamine	9-20	interleukin 1 beta	Homo sapiens	50-58
18026701-8	2007	Furthermore, glucosamine (1 mM) inhibited the IL-1beta-induced nitric oxide and PGE(2) production (p &lt; 0.05).	Glucosamine	13-24	interleukin 1 beta	Homo sapiens	46-54
18026701-8	2007	Furthermore, glucosamine (1 mM) inhibited the IL-1beta-induced nitric oxide and PGE(2) production (p &lt; 0.05).	Nitric Oxide	63-75	interleukin 1 beta	Homo sapiens	46-54
18026701-8	2007	Furthermore, glucosamine (1 mM) inhibited the IL-1beta-induced nitric oxide and PGE(2) production (p &lt; 0.05).	Prostaglandins E	80-83	interleukin 1 beta	Homo sapiens	46-54
18026701-9	2007	Moreover, glucosamine suppressed the IL-1beta-induced phosphorylation of p38 MAPK (p &lt; 0.05 at &gt;0.1 mM) and the IL-1beta-binding to its receptors (p &lt; 0.05 at 1 mM).	Glucosamine	10-21	interleukin 1 beta	Homo sapiens	37-45
18026701-9	2007	Moreover, glucosamine suppressed the IL-1beta-induced phosphorylation of p38 MAPK (p &lt; 0.05 at &gt;0.1 mM) and the IL-1beta-binding to its receptors (p &lt; 0.05 at 1 mM).	Glucosamine	10-21	interleukin 1 beta	Homo sapiens	118-126
18026701-10	2007	CONCLUSIONS: These observations suggest that glucosamine can suppress the IL-1beta-mediated activation of synoviocytes (such as IL-8-, nitric oxide- and PGE(2)-production, and phosphorylation of p38 MAPK), thereby possibly exhibiting antiinflammatory actions in arthritis.	Glucosamine	45-56	interleukin 1 beta	Homo sapiens	74-82
18026701-10	2007	CONCLUSIONS: These observations suggest that glucosamine can suppress the IL-1beta-mediated activation of synoviocytes (such as IL-8-, nitric oxide- and PGE(2)-production, and phosphorylation of p38 MAPK), thereby possibly exhibiting antiinflammatory actions in arthritis.	Nitric Oxide	135-147	interleukin 1 beta	Homo sapiens	74-82
17920466-4	2007	Phagocytosis of the polyethylene particles or retrieved polyethylene particles by differentiated U937 cells stimulated the release of cytokines including interleukin 1beta, interleukin 6, interleukin 8, and vascular endothelial growth factor.	Polyethylene	20-32	interleukin 1 beta	Homo sapiens	154-171
17700564-6	2007	IL-33 or IL-1beta also induced IL-8 and IL-13 production in naive HUCBMCs, and enhanced production of these cytokines in IgE/anti-IgE-stimulated HUCBMCs, without enhancing secretion of either PGD(2) or histamine.	Histamine	202-211	interleukin 1 beta	Homo sapiens	9-17
17920466-4	2007	Phagocytosis of the polyethylene particles or retrieved polyethylene particles by differentiated U937 cells stimulated the release of cytokines including interleukin 1beta, interleukin 6, interleukin 8, and vascular endothelial growth factor.	Polyethylene	56-68	interleukin 1 beta	Homo sapiens	154-171
17574271-15	2007	In vitro, Ro26-2198 inhibited IL-1beta-induced ERK activation and COX-2 induction and decreased HCA-7 cell proliferation.	1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3	10-19	interleukin 1 beta	Homo sapiens	30-38
17673675-6	2007	Tumor necrosis factor-alpha and interleukin (IL)-1beta stimulation of SMCs resulted in diphenylene iodonium-sensitive ROS production within intracellular vesicles.	diphenyleneiodonium	87-107	interleukin 1 beta	Homo sapiens	32-54
17675290-3	2007	We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by approximately 90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologic agonists tumor necrosis factor (TNF)-alpha, interleukin-1beta, lipopolysaccharide, and HOSCN without affecting expression of the NF-kappaB-regulated adhesion molecules ICAM-1 and E-selectin.	trichostatin A	13-16	interleukin 1 beta	Homo sapiens	282-299
17675290-3	2007	We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by approximately 90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologic agonists tumor necrosis factor (TNF)-alpha, interleukin-1beta, lipopolysaccharide, and HOSCN without affecting expression of the NF-kappaB-regulated adhesion molecules ICAM-1 and E-selectin.	entinostat	49-55	interleukin 1 beta	Homo sapiens	282-299
17675290-3	2007	We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by approximately 90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologic agonists tumor necrosis factor (TNF)-alpha, interleukin-1beta, lipopolysaccharide, and HOSCN without affecting expression of the NF-kappaB-regulated adhesion molecules ICAM-1 and E-selectin.	Butyric Acid	57-72	interleukin 1 beta	Homo sapiens	282-299
17673675-6	2007	Tumor necrosis factor-alpha and interleukin (IL)-1beta stimulation of SMCs resulted in diphenylene iodonium-sensitive ROS production within intracellular vesicles.	Reactive Oxygen Species	118-121	interleukin 1 beta	Homo sapiens	32-54
17673675-8	2007	ClC-3, an anion transporter that is primarily found in intracellular vesicles, also colocalized with Nox1 in early endosomes and was necessary for tumor necrosis factor-alpha and interleukin-1beta generation of ROS.	Reactive Oxygen Species	211-214	interleukin 1 beta	Homo sapiens	179-196
17673675-10	2007	We conclude that in response to tumor necrosis factor-alpha and interleukin-1beta, NADPH oxidase generates ROS within early endosomes and that Nox1 cannot produce sufficient ROS for cell signaling in the absence of ClC-3.	Reactive Oxygen Species	107-110	interleukin 1 beta	Homo sapiens	64-81
17675290-3	2007	We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by approximately 90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologic agonists tumor necrosis factor (TNF)-alpha, interleukin-1beta, lipopolysaccharide, and HOSCN without affecting expression of the NF-kappaB-regulated adhesion molecules ICAM-1 and E-selectin.	Valproic Acid	78-91	interleukin 1 beta	Homo sapiens	282-299
17681632-6	2007	It is reported that lipophilic statins enhance nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by interleukin-1beta (IL-1beta)-stimulated cardiomyocytes.	Nitric Oxide	47-59	interleukin 1 beta	Homo sapiens	152-160
17635918-5	2007	GS-HCl (but not GS sulfate, N-acetyl GS, or galactosamine HCl) resulted in a shift in the molecular mass of COX-2 from 72-74 to 66-70 kDa and concomitant inhibition of prostaglandin E(2) production in a concentration-dependent manner in interleukin (IL)-1beta-treated A549 human lung epithelial cells.	gs-hcl	0-6	interleukin 1 beta	Homo sapiens	237-259
17681632-8	2007	Treatment with GlcNAc-Ls-containing pravastatin specifically enhanced NO production and iNOS expression by IL-1beta-stimulated cardiomyocytes.	Acetylglucosamine	15-21	interleukin 1 beta	Homo sapiens	107-115
17681632-8	2007	Treatment with GlcNAc-Ls-containing pravastatin specifically enhanced NO production and iNOS expression by IL-1beta-stimulated cardiomyocytes.	Pravastatin	36-47	interleukin 1 beta	Homo sapiens	107-115
17635918-9	2007	Notably, GS-HCl (5 mM) also facilitated degradation of the higher molecular species of COX-2 in IL-1beta-treated A549 cells that was retarded by MG132.	gs-hcl	9-15	interleukin 1 beta	Homo sapiens	96-104
17635918-9	2007	Notably, GS-HCl (5 mM) also facilitated degradation of the higher molecular species of COX-2 in IL-1beta-treated A549 cells that was retarded by MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	145-150	interleukin 1 beta	Homo sapiens	96-104
17635918-10	2007	GS-HCl (5 mM) was also able to decrease the molecular mass of endogenous and IL-1beta- or tumor necrosis factor-alpha-driven COX-2 in different human cell lines, including Hep2 (bronchial) and H292 (laryngeal).	gs-hcl	0-6	interleukin 1 beta	Homo sapiens	77-85
18034979-8	2007	Of the 40 cytokines studied, levocetirizine (1 microM) was found to enhance the release of tissue inhibitor of metalloproteinases 1 and 4, matrix metalloproteinase 9, and heparin-binding epidermal growth factor and to attenuate the production of interleukins (IL)-1 beta and IL-7 and stem cell factor in lipopolysaccharide-stimulated human eosinophils.	levocetirizine	29-43	interleukin 1 beta	Homo sapiens	246-270
17869312-3	2007	Superoxide production was quantified in synovial cells obtained from six patients with rheumatoid arthritis (RA) and six with osteoarthritis (OA), stimulated with (i) AA, and (ii) PLA(2) inhibitors prior to IL-1beta or TNF-alpha treatment.	Superoxides	0-10	interleukin 1 beta	Homo sapiens	207-215
17495961-6	2007	Furthermore, incubation with DMF before stimulation with IL-1beta resulted in a significant decrease in NF-kappaB binding to the IL-8 kappaB and the IL-20 kappaB-binding sites as well as a subsequent decrease in IL-8 and IL-20 mRNA expression.	Dimethyl Fumarate	29-32	interleukin 1 beta	Homo sapiens	57-65
17690185-0	2007	Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	23-40
17690185-2	2007	However, dexamethasone"s impact on interleukin (IL)-1beta-dependent inflammatory angiogenesis is unknown.	Dexamethasone	9-22	interleukin 1 beta	Homo sapiens	35-57
17690185-6	2007	Dexamethasone significantly inhibited IkappaB-alpha phosphorylation 2 and 4 days after IL-1beta implantation.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	87-95
17690185-7	2007	Furthermore, dexamethasone inhibited IL-1beta-induced expression of vascular endothelial growth factor-A, KC, and prostaglandin E(2), and signaling of nuclear factor (NF)-kappaB in corneal fibroblasts in vitro.	Dexamethasone	13-26	interleukin 1 beta	Homo sapiens	37-45
17690185-7	2007	Furthermore, dexamethasone inhibited IL-1beta-induced expression of vascular endothelial growth factor-A, KC, and prostaglandin E(2), and signaling of nuclear factor (NF)-kappaB in corneal fibroblasts in vitro.	Prostaglandins E	114-129	interleukin 1 beta	Homo sapiens	37-45
17690185-9	2007	These findings suggest that NF-kappaB activation in the corneal stromal cells is an important early event during IL-1beta-induced corneal angiogenesis and that dexamethasone inhibits IL-1beta-induced angiogenesis partially via blocking NF-kappaB signaling.	Dexamethasone	160-173	interleukin 1 beta	Homo sapiens	183-191
17763411-0	2007	Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations.	Adenosine Triphosphate	77-80	interleukin 1 beta	Homo sapiens	11-28
17763411-7	2007	CONCLUSION: Our results showed that the requirements of ATP stimulation for IL-1beta release observed in healthy individuals are bypassed in patients bearing CIAS1 mutations.	Adenosine Triphosphate	56-59	interleukin 1 beta	Homo sapiens	76-84
17516123-2	2007	In this study, we demonstrate that cisplatin increased the early immediate release and de novo synthesis of proinflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6, through the activation of ERK and NF-kappaB in HEI-OC1 cells, which are conditionally immortalized cochlear cells that express hair cell markers.	Cisplatin	35-44	interleukin 1 beta	Homo sapiens	156-164
17845274-9	2007	The BDm sub-group, on the other hand, showed an increase in TNF-alpha and IL-4 values, with a low concentration of IL-1 and IL-2.	diacetylmonoxime	4-7	interleukin 1 beta	Homo sapiens	115-119
18078614-1	2007	OBJECTIVE: To study interleukin (IL)-1beta levels in recent onset RA patients treated either with combination DMARD therapy (sulfasalazine, methotrexate, hydroxychloroquine) or a single DMARD therapy.	Sulfasalazine	125-138	interleukin 1 beta	Homo sapiens	20-42
18078614-1	2007	OBJECTIVE: To study interleukin (IL)-1beta levels in recent onset RA patients treated either with combination DMARD therapy (sulfasalazine, methotrexate, hydroxychloroquine) or a single DMARD therapy.	Methotrexate	140-152	interleukin 1 beta	Homo sapiens	20-42
18078614-1	2007	OBJECTIVE: To study interleukin (IL)-1beta levels in recent onset RA patients treated either with combination DMARD therapy (sulfasalazine, methotrexate, hydroxychloroquine) or a single DMARD therapy.	Hydroxychloroquine	154-172	interleukin 1 beta	Homo sapiens	20-42
18078616-0	2007	Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	77-94
18078616-7	2007	Simvastatin significantly inhibited (about 20%) IL-6 and IL-8 production from IL-1-stimulated FLS.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	78-82
18078616-9	2007	Moreover, simvastatin produced a clear-cut inhibition of IL-1-induced NF-kB activation.	Simvastatin	10-21	interleukin 1 beta	Homo sapiens	57-61
18078616-10	2007	CONCLUSION: Simvastatin significantly inhibits the production of IL-6 and IL-8 also in IL-1-stimulated FLS, even though to a lesser extent than in unstimulated cells, via a HMG-CoA-reductase block with an interference in prenylation process and NF-kB activation.	Simvastatin	12-23	interleukin 1 beta	Homo sapiens	87-91
17825578-4	2007	In the present study, both TNF-alpha and IL-1beta not only revealed an immediate negative inotropic effect but also increased specific oxygen demand in human right-atrial myocardium.	Oxygen	135-141	interleukin 1 beta	Homo sapiens	41-49
17630199-8	2007	All flavonoids demonstrated an inhibitory effect on MAPK activation, interleukin, 1beta, and cyclooxygenase-2 (COX-2) expression, IL-1beta and prostaglandin E2 (PGE2) synthesis.	Flavonoids	4-14	interleukin 1 beta	Homo sapiens	69-87
17630199-8	2007	All flavonoids demonstrated an inhibitory effect on MAPK activation, interleukin, 1beta, and cyclooxygenase-2 (COX-2) expression, IL-1beta and prostaglandin E2 (PGE2) synthesis.	Flavonoids	4-14	interleukin 1 beta	Homo sapiens	130-138
17592175-0	2007	Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.	sphingosine phosphorylcholine	0-27	interleukin 1 beta	Homo sapiens	101-118
17592175-0	2007	Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.	Dinoprostone	127-143	interleukin 1 beta	Homo sapiens	101-118
17592175-4	2007	Interleukin-1beta-stimulated prostaglandin E(2) formation is dose-dependently suppressed by SPC, which is paralleled by reduced secretory phospholipase A(2) (sPLA(2)) protein expression and activity.	Dinoprostone	29-47	interleukin 1 beta	Homo sapiens	0-17
17681786-0	2007	Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells.	Berberine	0-9	interleukin 1 beta	Homo sapiens	49-66
17716606-11	2007	In conclusion, this study shows clearly that TNF-alpha and IL-1beta are harmful to early EPC and that the HMG-CoA reductase inhibitor simvastatin protects EPC from TNF-alpha- and eventually from IL-1beta-mediated apoptosis.	Simvastatin	134-145	interleukin 1 beta	Homo sapiens	195-203
17683829-6	2007	We further tested whether the intraperitoneal injection of IL-1beta, known to aggravate the ibotenate-induced lesions, could modify the expression pattern of VIP-related genes.	Ibotenic Acid	92-101	interleukin 1 beta	Homo sapiens	59-67
17683829-7	2007	Finally, we concluded using histological analysis that VIP[ala(11,22,28)], a synthetic VPAC(1) agonist completely reversed the aggravating effects of IL-1beta on ibotenate-induced lesions of the periventricular white matter.	Alanine	59-62	interleukin 1 beta	Homo sapiens	150-158
17683829-7	2007	Finally, we concluded using histological analysis that VIP[ala(11,22,28)], a synthetic VPAC(1) agonist completely reversed the aggravating effects of IL-1beta on ibotenate-induced lesions of the periventricular white matter.	Ibotenic Acid	162-171	interleukin 1 beta	Homo sapiens	150-158
17446059-5	2007	In this study, we investigated the effects of EGCG in attenuating the inflammatory response induced by interleukin (IL)-1beta+beta-amyloid (25-35) fragment (Abeta) in human astrocytoma, U373MG cells.	epigallocatechin gallate	46-50	interleukin 1 beta	Homo sapiens	103-125
17562851-3	2007	Moreover, the analysis of inflamed tissues showed that dihydrocucurbitacin B reduced the presence of the most relevant cytokines implicated in these processes, including interleukin-1 beta, interleukin-4, and tumor necrosis factor-alpha.	dihydrocucurbitacin B	55-76	interleukin 1 beta	Homo sapiens	170-188
17681786-3	2007	In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937).	Tetradecanoylphorbol Acetate	95-131	interleukin 1 beta	Homo sapiens	199-207
17681786-3	2007	In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937).	Hydrogen Peroxide	133-150	interleukin 1 beta	Homo sapiens	199-207
17681786-3	2007	In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937).	Okadaic Acid	152-164	interleukin 1 beta	Homo sapiens	199-207
17681786-3	2007	In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937).	Ceramides	169-177	interleukin 1 beta	Homo sapiens	199-207
17697350-11	2007	Progrado was exceptionally effective in reducing both basal and IL-1beta induced glycosaminoglycan release from human cartilage explants at concentrations that also directly blocked the gelatinolytic activity of MMP-2 and MMP-9.	Glycosaminoglycans	81-98	interleukin 1 beta	Homo sapiens	64-72
17692395-3	2007	Extracellular ATP stimulates a family of receptors, named P2, one of which, P2X(7), is a potent mediator of interleukin (IL)-1beta and IL-18 processing and release.	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	108-130
17428554-8	2007	IL-1beta also decreased IP(3) production and AA release, but significantly enhanced OT mediated PGE(2) production.	Inositol 1,4,5-Trisphosphate	24-29	interleukin 1 beta	Homo sapiens	0-8
17428554-8	2007	IL-1beta also decreased IP(3) production and AA release, but significantly enhanced OT mediated PGE(2) production.	Prostaglandins E	96-99	interleukin 1 beta	Homo sapiens	0-8
17428554-10	2007	CONCLUSION: Our data suggest, that IL-1beta indirectly increases OT secretion in primary cultures of human decidua in a time dependent fashion through the production of prostaglandins through COX-2 and that this increase in OT peptide may secondarily down-regulate the OTR and its signalling cascade.	Prostaglandins	169-183	interleukin 1 beta	Homo sapiens	35-43
17428554-3	2007	The present study evaluates the time-dependent effect [0-24 h] of the inflammatory cytokine Interleukin-1beta (IL-1beta) treatment on OT signalling and OT stimulated prostaglandin release in primary cultures of human decidua.	Prostaglandins	166-179	interleukin 1 beta	Homo sapiens	111-119
17666808-0	2007	IL-1beta genotype-related effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells under acute inflammation.	Prednisolone	36-48	interleukin 1 beta	Homo sapiens	0-8
17513456-7	2007	Furthermore, combination of IL-1beta and TNF-alpha has an additive effect on TSLP release by HASMC.	hasmc	93-98	interleukin 1 beta	Homo sapiens	28-36
17513456-8	2007	Primary HASMC pretreated with inhibitors of p38 or p42/p44 ERK MAPK, but not phosphatidylinositol 3-kinase, showed a significant decrease in TSLP release on IL-1beta and TNF-alpha treatment.	hasmc	8-13	interleukin 1 beta	Homo sapiens	157-165
17583797-5	2007	RESULTS: IL-1beta and MEKK1 specifically inhibited basal and membrane depolarisation and cAMP-induced INS transcription in the beta cell line.	Cyclic AMP	89-93	interleukin 1 beta	Homo sapiens	9-17
17513456-10	2007	Taken together, our data provide the first evidence of IL-1beta- and TNF-alpha-induced TSLP expression in HASMC via (p38, p42/p44) MAPK signaling pathways.	hasmc	106-111	interleukin 1 beta	Homo sapiens	55-63
17666808-0	2007	IL-1beta genotype-related effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells under acute inflammation.	Prednisolone	36-48	interleukin 1 beta	Homo sapiens	52-60
17666808-4	2007	In the present study, it was examined whether these IL-1beta genotypes were associated with the suppressive effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells (PBMC) stimulated by lipopolysaccharide (LPS).	Prednisolone	118-130	interleukin 1 beta	Homo sapiens	52-60
17666808-4	2007	In the present study, it was examined whether these IL-1beta genotypes were associated with the suppressive effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells (PBMC) stimulated by lipopolysaccharide (LPS).	Prednisolone	118-130	interleukin 1 beta	Homo sapiens	134-142
17666808-5	2007	A midrange concentration (10(-6) M) of prednisolone suppressed the LPS-induced increase in IL-1beta mRNA expression and protein release, while higher concentrations (10(-5) M, 10(-4) M) exhibited less suppression or had a synergistic stimulative effect on IL-1beta production in certain subjects.	Prednisolone	39-51	interleukin 1 beta	Homo sapiens	91-99
17666808-5	2007	A midrange concentration (10(-6) M) of prednisolone suppressed the LPS-induced increase in IL-1beta mRNA expression and protein release, while higher concentrations (10(-5) M, 10(-4) M) exhibited less suppression or had a synergistic stimulative effect on IL-1beta production in certain subjects.	Prednisolone	39-51	interleukin 1 beta	Homo sapiens	256-264
17563879-11	2007	The messenger RNA expression of IL-1-beta in lung tissue was significantly lower in the HFOV-treated animals (p &lt; 0.01).	hfov	88-92	interleukin 1 beta	Homo sapiens	32-41
17504902-5	2007	RESULTS: Metformin dose-dependently suppressed IL-1beta-induced IL-8 production, cAMP-induced mRNA expression and aromatase activity, and 5-bromo-2"-deoxyuridine incorporation in ESCs.	Metformin	9-18	interleukin 1 beta	Homo sapiens	47-55
17641275-8	2007	Using the NFkappaB inhibitor sulfasalazine and the AP-1 inhibitor SP600125, it became clear that the IL-1beta-induced decrease in TRalpha mRNA expression in HepG2 cells can only be abolished by simultaneous inhibition of NFkappaB and AP-1.	Sulfasalazine	29-42	interleukin 1 beta	Homo sapiens	101-109
17641275-9	2007	The IL-1beta-induced TRalpha1 and TRalpha2 mRNA decrease in HepG2 cells is the result of decreased TRalpha gene promoter activity, as evident from actinomycin D experiments.	Dactinomycin	147-160	interleukin 1 beta	Homo sapiens	4-12
17641275-8	2007	Using the NFkappaB inhibitor sulfasalazine and the AP-1 inhibitor SP600125, it became clear that the IL-1beta-induced decrease in TRalpha mRNA expression in HepG2 cells can only be abolished by simultaneous inhibition of NFkappaB and AP-1.	pyrazolanthrone	66-74	interleukin 1 beta	Homo sapiens	101-109
17442054-3	2007	Pre-treatment of immortalized HBMEC with atorvastatin (50 nmol/L to 1 micromol/L) dose-dependently prevented an inflammatory up-regulation of monocyte chemoattractant protein-1/CCL2 but not of interleukin-8/CXCL8 and intercellular adhesion molecule-1 expression by tumor necrosis factor-alpha or interleukin-1beta.	Atorvastatin	41-53	interleukin 1 beta	Homo sapiens	296-313
17429439-6	2007	We show here that key components of the inflammasome are present in human keratinocytes and that CS like trinitro-chlorobenzene induce caspase-1/ASC dependent IL-1beta and IL-18 processing and secretion.	Cesium	97-99	interleukin 1 beta	Homo sapiens	159-167
17429439-6	2007	We show here that key components of the inflammasome are present in human keratinocytes and that CS like trinitro-chlorobenzene induce caspase-1/ASC dependent IL-1beta and IL-18 processing and secretion.	Picryl Chloride	105-127	interleukin 1 beta	Homo sapiens	159-167
17559635-1	2007	BACKGROUND AND OBJECTIVE: Interleukin-1beta-stimulated receptor activator of nuclear factor-kappaB ligand (RANKL) expression in human periodontal ligament cells is partially mediated by endogenous prostaglandin E2, whereas mitogen-activated protein kinases (MAPKs) are implicated in regulating various interleukin-1-responsive genes.	Dinoprostone	197-213	interleukin 1 beta	Homo sapiens	26-43
17559635-9	2007	CONCLUSION: In human periodontal ligament cells, three types of MAPK inhibitor may abrogate RANKL expression and activity induced by interleukin-1beta, directly or indirectly through partial suppression of prostaglandin E2 synthesis.	Dinoprostone	206-222	interleukin 1 beta	Homo sapiens	133-150
17660728-10	2007	Furthermore, the plasmatic concentrations of IL-1beta, but not of CRP, negatively correlated with CHOL, LDLc, or TG levels and positively with those of CRP in T1D patients.	Thioguanine	113-115	interleukin 1 beta	Homo sapiens	45-53
17433832-11	2007	SP600125 significantly repressed LPS-stimulated release of IL-1beta and TNF-alpha at all concentrations, whereas LPS-stimulated IL-6, PGE(2) and PGF(2alpha) release were inhibited at 25 and 50 microM.	pyrazolanthrone	0-8	interleukin 1 beta	Homo sapiens	59-67
17666255-7	2007	CONCLUSION: Nasal fibroblasts stimulated with IL-1beta may take on the role of osteoblasts in osteoclastogenesis, which may be inhibited by macrolide antibiotics.	macrolide antibiotics	140-161	interleukin 1 beta	Homo sapiens	46-54
17340198-0	2007	Structural differences between the putative carbohydrate-recognition domains of human IL-1 alpha, IL-1 beta and IL-1 receptor antagonist obtained by in silico modeling.	Carbohydrates	44-56	interleukin 1 beta	Homo sapiens	98-107
17529908-4	2007	In contrast, interleukin 6 and tumor necrosis factor production were not affected and interleukin-1beta levels were actually increased with DMSO treatment.	Dimethyl Sulfoxide	140-144	interleukin 1 beta	Homo sapiens	86-103
17412815-6	2007	Destabilization of the cytoskeleton by inhibitors of MLCK (ML-7) or myosin II ATPase (blebbistatin) accelerates decidualization induced by cAMP (with E and P) but inhibits decidualization induced by IL-1beta (with E and P).	blebbistatin	86-98	interleukin 1 beta	Homo sapiens	199-207
17608808-4	2007	The release of interleukin-1beta and interleukin-6, nuclear translocation of NF-kappaB and its DNA binding activity in the SEC1-stimulated PBMC were time-dependent and were completely eliminated by pyrrolidine dithiocarbamate or SN-50 (NF-kappaB inhibitors).	pyrrolidine dithiocarbamic acid	198-225	interleukin 1 beta	Homo sapiens	15-32
17634253-0	2007	Interleukin1beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndrome.	Fatty Acids, Unsaturated	53-80	interleukin 1 beta	Homo sapiens	0-16
17562385-3	2007	Compared to the control group, intracerebroventricular pretreatment of kainic acid significantly attenuated nocifensive behaviors induced by intraplantar formalin (only in the 2nd phase), intrathecal glutamate, TNF-alpha or IL-1beta.	Kainic Acid	71-82	interleukin 1 beta	Homo sapiens	224-232
17426109-0	2007	High glucose induces IL-1beta expression in human monocytes: mechanistic insights.	Glucose	5-12	interleukin 1 beta	Homo sapiens	21-29
17426109-2	2007	In this study, we aimed to delineate the mechanism of IL-1beta induction under high-glucose (HG) conditions in human monocytes.	Glucose	84-91	interleukin 1 beta	Homo sapiens	54-62
17605605-6	2007	RESULTS: IL-1-GLN-CS and GLN-CS treatments decreased nitrite release, compared with IL-1 treatment; IL-1-GLN-CS treatment decreased IL-1-induced PGE(2) release.	gln-cs	14-20	interleukin 1 beta	Homo sapiens	9-13
17605605-6	2007	RESULTS: IL-1-GLN-CS and GLN-CS treatments decreased nitrite release, compared with IL-1 treatment; IL-1-GLN-CS treatment decreased IL-1-induced PGE(2) release.	Nitrites	53-60	interleukin 1 beta	Homo sapiens	9-13
17605605-6	2007	RESULTS: IL-1-GLN-CS and GLN-CS treatments decreased nitrite release, compared with IL-1 treatment; IL-1-GLN-CS treatment decreased IL-1-induced PGE(2) release.	Prostaglandins E	145-148	interleukin 1 beta	Homo sapiens	9-13
17605605-8	2007	Interleukin-1-induced mRNA expressions of proteolytic enzymes were diminished by IL-1-GLN-CS treatment.	gln-cs	86-92	interleukin 1 beta	Homo sapiens	81-85
17605605-10	2007	Transcripts of TIMP-3 were increased by IL-1-GLN-CS treatment, compared with IL-1 treatment.	Glucosamine	45-48	interleukin 1 beta	Homo sapiens	40-44
17605605-10	2007	Transcripts of TIMP-3 were increased by IL-1-GLN-CS treatment, compared with IL-1 treatment.	Chondroitin Sulfates	49-51	interleukin 1 beta	Homo sapiens	40-44
17510469-8	2007	In addition, inhibitors of adenylyl cyclase and protein kinase A (PKA) restored IL-1beta signaling in apoE-treated VSMCs, whereas apoE stimulated PKA activity.	vsmcs	115-120	interleukin 1 beta	Homo sapiens	80-88
17340198-2	2007	J Biol Chem 276 (2001) 5685-5691), it was established that biologically active recombinant human IL-1alpha and IL-1beta had different carbohydrate-binding properties.	Carbohydrates	134-146	interleukin 1 beta	Homo sapiens	111-119
17340198-3	2007	IL-1alpha recognized a di-antennary N-glycan with two alpha2-3-linked sialic acid residues, whereas IL-1beta recognized the GM(4), a alpha2-3-linked sialylated glycosphingolipid.	gm	124-126	interleukin 1 beta	Homo sapiens	100-108
17340198-3	2007	IL-1alpha recognized a di-antennary N-glycan with two alpha2-3-linked sialic acid residues, whereas IL-1beta recognized the GM(4), a alpha2-3-linked sialylated glycosphingolipid.	Glycosphingolipids	160-177	interleukin 1 beta	Homo sapiens	100-108
17499191-6	2007	At an in vitro dose of 20 mug/ml of PL and 5 mug/ml of piperinic acid, there was a significant inhibition of mitogen induced human PBMC proliferation, mRNA transcripts of IL-2 (ConA) and TNFalpha, IL-1beta and iNOS (LPS) respectively under stimulated conditions in time dependent (6 h, 12 h and 24 h respectively) expression studies.	piperinic acid	55-69	interleukin 1 beta	Homo sapiens	197-205
17502394-6	2007	In contrast, vaccination with JBCG resulted in significantly greater expression of cytokines characteristic of a proinflammatory immune response (IL-1alpha, IL-1beta, IL-6, and IL-24) in PBMC activated with CFP compared to PBMC from children vaccinated with BBCG or DBCG.	jbcg	30-34	interleukin 1 beta	Homo sapiens	157-165
17221363-10	2007	Moreover, plasma IL-1 beta, TNF-alpha and MCP-1 levels were positively correlated with clinical and well-establish biochemical parameters of pregnancy toxaemia, serum uric acid and proteinuria (p&lt;0.01).	Uric Acid	167-176	interleukin 1 beta	Homo sapiens	17-26
17463301-5	2007	After IH for 8 wk, hypoxia- and exercise-promoted EPA, IL-1beta, or malondialdehyde levels were suppressed in both MIH and SIH groups, and plasma IL-6 and IL-10 levels in the SIH group were increased.	Procarbazine	115-118	interleukin 1 beta	Homo sapiens	55-63
17463301-7	2007	Therefore, both MIH and SIH regimens ameliorate eosinophil- and platelet-related thrombosis, proinflammatory IL-1beta secretion, and lipid peroxidation enhanced by strenuous exercise.	Procarbazine	16-19	interleukin 1 beta	Homo sapiens	109-117
17348037-7	2007	These observations show that stretch, IL-1beta and anisomycin activate the same components of the MAPK cascade, but differentially activate LAP and liver inhibitory protein (LIP) perhaps accounting for the increase in OTR by stretch and anisomycin but not IL-1beta observed in this study.	Anisomycin	51-61	interleukin 1 beta	Homo sapiens	256-264
17348037-7	2007	These observations show that stretch, IL-1beta and anisomycin activate the same components of the MAPK cascade, but differentially activate LAP and liver inhibitory protein (LIP) perhaps accounting for the increase in OTR by stretch and anisomycin but not IL-1beta observed in this study.	Anisomycin	237-247	interleukin 1 beta	Homo sapiens	38-46
17348037-7	2007	These observations show that stretch, IL-1beta and anisomycin activate the same components of the MAPK cascade, but differentially activate LAP and liver inhibitory protein (LIP) perhaps accounting for the increase in OTR by stretch and anisomycin but not IL-1beta observed in this study.	Anisomycin	237-247	interleukin 1 beta	Homo sapiens	256-264
17403097-11	2007	Results from COX-1 and COX-2 silencing and selective inhibition showed that both COX-1 and COX-2 were involved in the biosynthesis of PGE(2) and their relative contribution depended on the time of incubation with IL-1beta.	Prostaglandins E	134-137	interleukin 1 beta	Homo sapiens	213-221
17386941-2	2007	We report here that non-tyrosine phosphorylated (NTP)-Stat1 is involved in a cooperative interaction with Spi-1/PU.1 and IRF8 to form a pre-associated, poised complex for IL1B gene induction.	Tyrosine	24-32	interleukin 1 beta	Homo sapiens	171-175
17525067-5	2007	METHODS AND RESULTS: Co-stimulation with LIF and IL-1beta induced higher amounts of PGE2 production and further migration of HTR-8/SVneo cells compared with that by stimulation with LIF or IL-1beta alone.	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	49-57
17485153-7	2007	Aluminum-containing adjuvants stimulated the release of IL-1beta and IL-18 from DCs via caspase-1 activation.	Aluminum	0-8	interleukin 1 beta	Homo sapiens	56-64
17499637-0	2007	Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection.	Flavonoids	86-96	interleukin 1 beta	Homo sapiens	14-31
17499637-3	2007	Flavonoids significantly decreased the release of reactive oxygen species (ROS) from astrocytes stimulated with IL-1beta.	Flavonoids	0-10	interleukin 1 beta	Homo sapiens	112-120
17499637-3	2007	Flavonoids significantly decreased the release of reactive oxygen species (ROS) from astrocytes stimulated with IL-1beta.	Reactive Oxygen Species	50-73	interleukin 1 beta	Homo sapiens	112-120
17499637-3	2007	Flavonoids significantly decreased the release of reactive oxygen species (ROS) from astrocytes stimulated with IL-1beta.	Reactive Oxygen Species	75-78	interleukin 1 beta	Homo sapiens	112-120
17499637-6	2007	Significant decrease in neuronal apoptosis was observed in neurons cultured in conditioned medium obtained from astrocytes treated with a combination of IL-1beta and flavonoids as compared to that treated with IL-1beta alone.	Flavonoids	166-176	interleukin 1 beta	Homo sapiens	210-218
17573191-2	2007	Endogenous agents such as TNF-alpha, INF-gamma, IL-1beta and others stress signals activate the sphingomyelin pathway increasing ceramide levels.	Sphingomyelins	96-109	interleukin 1 beta	Homo sapiens	48-56
17573191-2	2007	Endogenous agents such as TNF-alpha, INF-gamma, IL-1beta and others stress signals activate the sphingomyelin pathway increasing ceramide levels.	Ceramides	129-137	interleukin 1 beta	Homo sapiens	48-56
17512458-6	2007	Treatment of placenta and fetal membranes with 15-A(2)-IsoP caused a dose-dependent decrease in LPS-stimulated release of the cytokines IL-1beta, IL-6, IL-8, and TNF-alpha and the prostaglandins PGE(2) and PGF(2)alpha.	15-a(2)-isop	47-59	interleukin 1 beta	Homo sapiens	136-144
17445771-4	2007	Under IL-1beta signaling, treatment of NF-kappaB nuclear translocation inhibitor SN-50 reduced Lef1 expression.	SN-50	81-86	interleukin 1 beta	Homo sapiens	6-14
17485153-12	2007	These results indicate that aluminum-containing adjuvants activate DCs and influence their ability to direct T(H)1 and T(H)2 responses through the secretion of IL-1beta and IL-18.	Aluminum	28-36	interleukin 1 beta	Homo sapiens	160-168
17277048-9	2007	IL-1beta and EGF sensitization of adenylyl cyclase activity was also sensitive to raf-1 kinase inhibition by GW5074.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	109-115	interleukin 1 beta	Homo sapiens	0-8
17179173-13	2007	Knockdown of the STAT1 gene by specific siRNA or its inhibition with fludarabine partially restored the IL1beta induction of MMP13 expression and promoter activity.	fludarabine	69-80	interleukin 1 beta	Homo sapiens	104-111
17322416-2	2007	The present study was undertaken to investigate the effect of sirolimus on intracellular cholesterol homeostasis in human vascular smooth muscle cells (VSMCs) in the presence of inflammatory cytokine IL-1 beta.	Sirolimus	62-71	interleukin 1 beta	Homo sapiens	200-209
17322416-3	2007	We explored the effect of sirolimus on the lipid accumulation of VSMCs in the presence of IL-1 beta, using Oil Red O staining and quantitative measurement of intracellular cholesterol.	Sirolimus	26-35	interleukin 1 beta	Homo sapiens	90-99
17322416-7	2007	Sirolimus reduced intracellular lipid accumulation in VSMCs mediated by IL-1 beta possibly due to the reduction of expression of low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) receptors.	Sirolimus	0-9	interleukin 1 beta	Homo sapiens	72-81
17322416-8	2007	Sirolimus increased cholesterol efflux from VSMCs and overrode the suppression of cholesterol efflux induced by IL-1 beta.	Sirolimus	0-9	interleukin 1 beta	Homo sapiens	112-121
17322416-8	2007	Sirolimus increased cholesterol efflux from VSMCs and overrode the suppression of cholesterol efflux induced by IL-1 beta.	Cholesterol	82-93	interleukin 1 beta	Homo sapiens	112-121
17322416-9	2007	Sirolimus also increased ABCA1 and ABCG1 genes expression, even in the presence of IL-1 beta.	Sirolimus	0-9	interleukin 1 beta	Homo sapiens	83-92
17348859-3	2007	Thus pharmacological inhibition of RIP2 kinase with either SB 203580 [a p38 MAPK (mitogen-activated protein kinase) inhibitor] or the Src family kinase inhibitor PP2 induces a rapid and drastic decrease in the level of the RIP2 protein, which may explain why these RIP2 inhibitors block MDP-stimulated downstream signalling and the production of IL-1beta (interleukin-1beta) and TNFalpha (tumour necrosis factor-alpha).	SB 203580	59-68	interleukin 1 beta	Homo sapiens	346-354
17348859-3	2007	Thus pharmacological inhibition of RIP2 kinase with either SB 203580 [a p38 MAPK (mitogen-activated protein kinase) inhibitor] or the Src family kinase inhibitor PP2 induces a rapid and drastic decrease in the level of the RIP2 protein, which may explain why these RIP2 inhibitors block MDP-stimulated downstream signalling and the production of IL-1beta (interleukin-1beta) and TNFalpha (tumour necrosis factor-alpha).	SB 203580	59-68	interleukin 1 beta	Homo sapiens	356-373
17516992-0	2007	Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin.	Tamoxifen	159-168	interleukin 1 beta	Homo sapiens	25-80
17509446-8	2007	When PBMC were cultured with a2NTD, there was a 2.5-fold increase in IL1A and IL1B gene expression and no induction of TNF gene expression.	a2ntd	29-34	interleukin 1 beta	Homo sapiens	78-82
17570156-6	2007	Using human myometrial cells in culture, we demonstrated that PDE4B2 can be induced by its own substrate, under the control of one of the major utero-contractile agonists, PGE2, itself upregulated by the proinflammatory cytokine IL-1beta.	Dinoprostone	172-176	interleukin 1 beta	Homo sapiens	229-237
17509446-10	2007	Finally, there was a 204-fold increase in intracellular expression of IL-1beta in monocytes incubated with a2NTD.	a2ntd	107-112	interleukin 1 beta	Homo sapiens	70-78
17211836-8	2007	In addition, IL-1beta treatments stimulated bumetanide-sensitive fluid transport across the NHMEE cell monolayers.	Bumetanide	44-54	interleukin 1 beta	Homo sapiens	13-21
17504508-9	2007	Monocytes of patients with CARD15 polymorphisms showed an early reduced cytokine response (IL-1beta, IL-6 and IL-10) to infection with AIEC, which was restored after 20 h. A gene-dose effect was seen, comparing wild-types, heterozygotes and homozygotes.	aiec	135-139	interleukin 1 beta	Homo sapiens	91-99
17299794-10	2007	Up-regulation of ICAM-1 enhanced the adhesion of neutrophils onto A549 cell monolayer exposed to IL-1beta, which was inhibited by PP1, AG1296, LY294002, wortmannin, and helenalin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	interleukin 1 beta	Homo sapiens	97-105
17299794-4	2007	We initially observed that IL-1beta-induced ICAM-1 promoter activity was attenuated by the inhibitors of Src (PP1), PDGFR (AG1296), PI3-K (LY294002 and wortmannin), and Akt (SH-5), revealed by reporter gene assay, Western blotting, and RT-PCR analyses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	interleukin 1 beta	Homo sapiens	27-35
17226775-8	2007	In addition, IL-1beta increased the synthesis of the population of proteoglycans that separated at the SDS-PAGE gel interface.	Sodium Dodecyl Sulfate	103-106	interleukin 1 beta	Homo sapiens	13-21
17226775-10	2007	These data demonstrate that IL-1beta selectively downregulates versican synthesis by ASMC, while positively regulating the synthesis of other proteoglycans.	asmc	85-89	interleukin 1 beta	Homo sapiens	28-36
17299794-4	2007	We initially observed that IL-1beta-induced ICAM-1 promoter activity was attenuated by the inhibitors of Src (PP1), PDGFR (AG1296), PI3-K (LY294002 and wortmannin), and Akt (SH-5), revealed by reporter gene assay, Western blotting, and RT-PCR analyses.	Wortmannin	152-162	interleukin 1 beta	Homo sapiens	27-35
17299794-10	2007	Up-regulation of ICAM-1 enhanced the adhesion of neutrophils onto A549 cell monolayer exposed to IL-1beta, which was inhibited by PP1, AG1296, LY294002, wortmannin, and helenalin.	Wortmannin	153-163	interleukin 1 beta	Homo sapiens	97-105
17299794-6	2007	Src, PDGFR, and PI3K/Akt mediated the effects of IL-1beta because pretreatment with PP1, AG1296, and wortmannin also abrogated IL-1beta-stimulated Src, PDGFR, and Akt phosphorylation, respectively.	6,7-dimethoxy-3-phenylquinoxaline	89-95	interleukin 1 beta	Homo sapiens	49-57
17311279-5	2007	IL-1beta induced production of MMP-9 protein and mRNA in a time- and concentration-dependent manner determined by zymographic, Western blotting, and RT-PCR analyses, which was attenuated by inhibitors of MEK1/2 (U0126), p38 MAPK (SB202190), JNK (SP600125), and NF-kappaB (helenalin), and transfection with dominant negative mutants of MEK1/2, p38 and JNK, respectively.	pyrazolanthrone	246-254	interleukin 1 beta	Homo sapiens	0-8
17299794-6	2007	Src, PDGFR, and PI3K/Akt mediated the effects of IL-1beta because pretreatment with PP1, AG1296, and wortmannin also abrogated IL-1beta-stimulated Src, PDGFR, and Akt phosphorylation, respectively.	6,7-dimethoxy-3-phenylquinoxaline	89-95	interleukin 1 beta	Homo sapiens	127-135
17299794-6	2007	Src, PDGFR, and PI3K/Akt mediated the effects of IL-1beta because pretreatment with PP1, AG1296, and wortmannin also abrogated IL-1beta-stimulated Src, PDGFR, and Akt phosphorylation, respectively.	Wortmannin	101-111	interleukin 1 beta	Homo sapiens	49-57
17299794-6	2007	Src, PDGFR, and PI3K/Akt mediated the effects of IL-1beta because pretreatment with PP1, AG1296, and wortmannin also abrogated IL-1beta-stimulated Src, PDGFR, and Akt phosphorylation, respectively.	Wortmannin	101-111	interleukin 1 beta	Homo sapiens	127-135
17311279-6	2007	IL-1beta-stimulated phosphorylation of p42/p44 MAPK, p38 MAPK, and JNK was attenuated by pretreatment with U0126, SB202190, SP600125, or transfection with these dominant negative mutants of MEK, ERK, p38 and JNK, respectively.	U 0126	107-112	interleukin 1 beta	Homo sapiens	0-8
17311279-6	2007	IL-1beta-stimulated phosphorylation of p42/p44 MAPK, p38 MAPK, and JNK was attenuated by pretreatment with U0126, SB202190, SP600125, or transfection with these dominant negative mutants of MEK, ERK, p38 and JNK, respectively.	pyrazolanthrone	124-132	interleukin 1 beta	Homo sapiens	0-8
17311279-7	2007	Furthermore, IL-1beta-stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha was blocked by helenalin.	helenalin	125-134	interleukin 1 beta	Homo sapiens	13-21
17509409-4	2007	Eugenol was shown to block the release of the bone resorbing mediators, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 from LPS-stimulated macrophages.	Eugenol	0-7	interleukin 1 beta	Homo sapiens	82-99
17509409-4	2007	Eugenol was shown to block the release of the bone resorbing mediators, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 from LPS-stimulated macrophages.	Eugenol	0-7	interleukin 1 beta	Homo sapiens	101-109
17311279-9	2007	MMP-9 promoter activity was enhanced by IL-1beta in HTSMCs transfected with MMP-9-Luc, which was inhibited by helenalin, U0126, SB202190, and SP600125.	helenalin	110-119	interleukin 1 beta	Homo sapiens	40-48
17509409-6	2007	Consistent with downregulation of bone-resorbing mediators, eugenol suppressed the messenger RNA expression of LPS-induced IL-1beta, TNF-alpha, and cyclooxygenase-2 in macrophages.	Eugenol	60-67	interleukin 1 beta	Homo sapiens	123-131
17311279-9	2007	MMP-9 promoter activity was enhanced by IL-1beta in HTSMCs transfected with MMP-9-Luc, which was inhibited by helenalin, U0126, SB202190, and SP600125.	U 0126	121-126	interleukin 1 beta	Homo sapiens	40-48
17311279-9	2007	MMP-9 promoter activity was enhanced by IL-1beta in HTSMCs transfected with MMP-9-Luc, which was inhibited by helenalin, U0126, SB202190, and SP600125.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	128-136	interleukin 1 beta	Homo sapiens	40-48
17311279-9	2007	MMP-9 promoter activity was enhanced by IL-1beta in HTSMCs transfected with MMP-9-Luc, which was inhibited by helenalin, U0126, SB202190, and SP600125.	pyrazolanthrone	142-150	interleukin 1 beta	Homo sapiens	40-48
17572009-4	2007	In the present study, using a substrate-specific enzymatic assay, we show that treatment of caspase-1 (interleukin-1beta [IL-1beta] converting enzyme [ICE]) with AS101 inhibits its enzymatic activity in a dose-dependent manner.	ammonium trichloro(dioxoethylene-O,O'-)tellurate	162-167	interleukin 1 beta	Homo sapiens	103-120
17513787-2	2007	We determined the effects of dexamethasone on GRO-alpha induced by IL-1beta or TNF-alpha with respect to the role of MAPK pathways and of MAPK phosphatase-1 (MKP-1).	Dexamethasone	29-42	interleukin 1 beta	Homo sapiens	67-75
17572009-4	2007	In the present study, using a substrate-specific enzymatic assay, we show that treatment of caspase-1 (interleukin-1beta [IL-1beta] converting enzyme [ICE]) with AS101 inhibits its enzymatic activity in a dose-dependent manner.	ammonium trichloro(dioxoethylene-O,O'-)tellurate	162-167	interleukin 1 beta	Homo sapiens	122-130
17513787-4	2007	Dexamethasone (10(-8)-10(-5) M) partially inhibited GRO-alpha expression and release induced by IL-1beta and TNF-alpha; this was associated with an inhibition of JNK, but not of p38 or ERK phosphorylation.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	96-104
17513787-5	2007	Together with IL-1beta or TNF-alpha, dexamethasone rapidly induced mRNA and protein expression of MKP-1, which dephosphorylates MAPKs.	Dexamethasone	37-50	interleukin 1 beta	Homo sapiens	14-22
17572009-5	2007	Moreover, the results show that AS101 treatment causes a significant reduction in the active form of IL-18 and IL-1beta in peripheral blood mononuclear cells (PBMC) and in human HaCat keratinocytes.	ammonium trichloro(dioxoethylene-O,O'-)tellurate	32-37	interleukin 1 beta	Homo sapiens	111-119
17136479-5	2007	N-tosyl phenylalanyl chloromethyl ketone (TPCK), wortmannin and Ly294002 inhibited IL-1beta-induced NF-kappaB activation in both systems indicating involvement of the PI3K axis in this response.	n-tosyl phenylalanyl chloromethyl ketone	0-40	interleukin 1 beta	Homo sapiens	83-91
17513787-9	2007	Nuclear translocation of the glucocorticoid receptor was increased in ASMC exposed to dexamethasone and IL-1beta.	asmc	70-74	interleukin 1 beta	Homo sapiens	104-112
17388968-3	2007	OBJECTIVES: In the present study, we evaluated the effect of various wine polyphenolic compounds and several active synthetic derivatives of resveratrol on the inflammatory cytokines (IL-1beta + IL-6)-induced CRP expression in Hep3B cells.	Resveratrol	141-152	interleukin 1 beta	Homo sapiens	184-192
17620201-8	2007	Cotreatment with an inhibitor of IL-1beta and TNF-alpha synthesis, pentoxifylline, decreased stilbene estrogen-induced levels of myeloperoxidase (MPO), 8-hydroxydeoxyguanosine formation, and gene mutations, and prevented stilbene estrogen-induced lesions.	Pentoxifylline	67-81	interleukin 1 beta	Homo sapiens	33-41
17275031-10	2007	The IL-1beta-induced ICAM-1 was also inhibited by a potent inhibitor of NF-kappaB, MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	83-88	interleukin 1 beta	Homo sapiens	4-12
17620201-8	2007	Cotreatment with an inhibitor of IL-1beta and TNF-alpha synthesis, pentoxifylline, decreased stilbene estrogen-induced levels of myeloperoxidase (MPO), 8-hydroxydeoxyguanosine formation, and gene mutations, and prevented stilbene estrogen-induced lesions.	Stilbenes	93-101	interleukin 1 beta	Homo sapiens	33-41
17620201-8	2007	Cotreatment with an inhibitor of IL-1beta and TNF-alpha synthesis, pentoxifylline, decreased stilbene estrogen-induced levels of myeloperoxidase (MPO), 8-hydroxydeoxyguanosine formation, and gene mutations, and prevented stilbene estrogen-induced lesions.	8-ohdg	152-175	interleukin 1 beta	Homo sapiens	33-41
17620201-8	2007	Cotreatment with an inhibitor of IL-1beta and TNF-alpha synthesis, pentoxifylline, decreased stilbene estrogen-induced levels of myeloperoxidase (MPO), 8-hydroxydeoxyguanosine formation, and gene mutations, and prevented stilbene estrogen-induced lesions.	Stilbenes	221-229	interleukin 1 beta	Homo sapiens	33-41
17136479-5	2007	N-tosyl phenylalanyl chloromethyl ketone (TPCK), wortmannin and Ly294002 inhibited IL-1beta-induced NF-kappaB activation in both systems indicating involvement of the PI3K axis in this response.	Wortmannin	49-59	interleukin 1 beta	Homo sapiens	83-91
17136479-5	2007	N-tosyl phenylalanyl chloromethyl ketone (TPCK), wortmannin and Ly294002 inhibited IL-1beta-induced NF-kappaB activation in both systems indicating involvement of the PI3K axis in this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	interleukin 1 beta	Homo sapiens	83-91
17380484-1	2007	Molecular dynamics simulations reveal that the hydrophobic cavity in human cytokine Interleukin-1beta is hydrated and can dynamically accommodate between one and four water molecules.	Water	167-172	interleukin 1 beta	Homo sapiens	84-101
17337215-9	2007	GlcN treatment partially blocked IL-1beta mediated downregulation of collagen II and aggrecan expression and inhibited expression of the matrix degrading enzyme, matrix metalloproteinase 13 (MMP-13), in both chondrocytes and hMSCs undergoing chondrogenesis.	Glucosamine	0-4	interleukin 1 beta	Homo sapiens	33-41
17481780-4	2007	In investigating whether JNK was involved in IL-1beta-induced CGRP secretion, the JNK II inhibitor SP600125 was used and it significantly attenuated IL-1beta-induced CGRP secretion and c-Jun activity, which was elevated after IL-1beta stimulation from mRNA to protein level.	pyrazolanthrone	99-107	interleukin 1 beta	Homo sapiens	45-53
17481780-4	2007	In investigating whether JNK was involved in IL-1beta-induced CGRP secretion, the JNK II inhibitor SP600125 was used and it significantly attenuated IL-1beta-induced CGRP secretion and c-Jun activity, which was elevated after IL-1beta stimulation from mRNA to protein level.	pyrazolanthrone	99-107	interleukin 1 beta	Homo sapiens	149-157
17481780-4	2007	In investigating whether JNK was involved in IL-1beta-induced CGRP secretion, the JNK II inhibitor SP600125 was used and it significantly attenuated IL-1beta-induced CGRP secretion and c-Jun activity, which was elevated after IL-1beta stimulation from mRNA to protein level.	pyrazolanthrone	99-107	interleukin 1 beta	Homo sapiens	149-157
17380484-16	2007	(J Mol Biol 2005; 353:1187-1198) that hydrogen bond networks couple motions across long distances in interleukin-1beta, lead us to hypothesize that the hydration of the cavity (conserved across mammals) can thermodynamically enhance hydrogen bond networks to enable coupling across long distances by acting as a plug and this in turn enables a kinetic control of the rate of transmission of signals.	Hydrogen	38-46	interleukin 1 beta	Homo sapiens	101-118
17380484-16	2007	(J Mol Biol 2005; 353:1187-1198) that hydrogen bond networks couple motions across long distances in interleukin-1beta, lead us to hypothesize that the hydration of the cavity (conserved across mammals) can thermodynamically enhance hydrogen bond networks to enable coupling across long distances by acting as a plug and this in turn enables a kinetic control of the rate of transmission of signals.	Hydrogen	233-241	interleukin 1 beta	Homo sapiens	101-118
17407761-5	2007	Here, we report for the first time on the use of lentiviral vector-based shRNA delivery to efficiently suppress the IL-1beta-mediated induction of iNOS expression, the accumulation of nitrite and provide significant protection against the cytotoxic effects of IL-1beta exposure.	Nitrites	184-191	interleukin 1 beta	Homo sapiens	116-124
17314215-2	2007	In this study, we explored the effect of artesunate, an artemisinin derivative, on tumour necrosis factor (TNF)-alpha-induced production of interleukins, IL-1beta, IL-6 and IL-8, in human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), and further investigated the signal mechanism by which this compound modulates those cytokines" production.	Artesunate	41-51	interleukin 1 beta	Homo sapiens	154-162
17314215-6	2007	RESULTS: Artesunate decreased the secretion of IL-1beta, IL-6 and IL-8 from TNF-alpha-stimulated RA FLS in a dose-dependent manner.	Artesunate	9-19	interleukin 1 beta	Homo sapiens	47-55
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	80-107	interleukin 1 beta	Homo sapiens	18-26
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	109-113	interleukin 1 beta	Homo sapiens	18-26
17314215-9	2007	These observations suggest that artesunate inhibits production of IL-1beta, IL-6 and IL-8 through inhibition of NF-kappaB signalling pathway.	Artesunate	32-42	interleukin 1 beta	Homo sapiens	66-74
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	interleukin 1 beta	Homo sapiens	32-40
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	interleukin 1 beta	Homo sapiens	206-214
17395587-4	2007	Salmeterol and salbutamol enhanced rhinovirus- and IL-1beta-induced IL-6 production; however, fluticasone treatment caused a reduction of IL-6 protein and mRNA.	Salmeterol Xinafoate	0-10	interleukin 1 beta	Homo sapiens	51-59
17395587-4	2007	Salmeterol and salbutamol enhanced rhinovirus- and IL-1beta-induced IL-6 production; however, fluticasone treatment caused a reduction of IL-6 protein and mRNA.	Albuterol	15-25	interleukin 1 beta	Homo sapiens	51-59
17291458-3	2007	The purpose of this study was to examine the effects of curcumin (diferuloylmethane), a pharmacologically safe phytochemical agent with potent anti-inflammatory properties on IL-1beta and TNF-alpha signalling pathways in human articular chondrocytes maintained in vitro.	Curcumin	56-64	interleukin 1 beta	Homo sapiens	175-183
17524151-8	2007	Also, roxithromycin inhibited the SM-stimulated overproduction of the proinflammatory cytokines IL-1beta, IL-6, IL-8 and TNF at both the protein level and the mRNA level, as measured by either enzyme-linked immunosorbent assay (ELISA) or real-time RT-PCR.	Roxithromycin	6-19	interleukin 1 beta	Homo sapiens	96-104
17524151-8	2007	Also, roxithromycin inhibited the SM-stimulated overproduction of the proinflammatory cytokines IL-1beta, IL-6, IL-8 and TNF at both the protein level and the mRNA level, as measured by either enzyme-linked immunosorbent assay (ELISA) or real-time RT-PCR.	Mustard Gas	34-36	interleukin 1 beta	Homo sapiens	96-104
17386065-5	2007	Conversely, patients with ALC and at least 1 year of alcohol withdrawal (ALCAW group) showed a decreased number of total circulating DC, whereas ALC patients with active EtOH intake (ALCET group) had an abnormally low production of IL1beta and TNFalpha by PB DC.	alcet	183-188	interleukin 1 beta	Homo sapiens	232-239
17291458-3	2007	The purpose of this study was to examine the effects of curcumin (diferuloylmethane), a pharmacologically safe phytochemical agent with potent anti-inflammatory properties on IL-1beta and TNF-alpha signalling pathways in human articular chondrocytes maintained in vitro.	Curcumin	66-83	interleukin 1 beta	Homo sapiens	175-183
17291458-7	2007	Treatment of chondrocytes with curcumin suppressed IL-1beta-induced NF-kappaB activation via inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation and p65 nuclear translocation.	Curcumin	31-39	interleukin 1 beta	Homo sapiens	51-59
17291458-8	2007	Curcumin inhibited the IL-1beta-induced stimulation of up-stream protein kinase B Akt.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	23-31
17291458-11	2007	Curcumin also reversed the IL-1beta-induced down-regulation of collagen type II and beta1-integrin receptor expression.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	27-35
17291458-12	2007	These results indicate that curcumin has nutritional potential as a naturally occurring anti-inflammatory agent for treating OA through suppression of NF-kappaB mediated IL-1beta/TNF-alpha catabolic signalling pathways in chondrocytes.	Curcumin	28-36	interleukin 1 beta	Homo sapiens	170-178
17533579-0	2007	Inverse relationship between serum levels of interleukin-1beta and testosterone in men with stable coronary artery disease.	Testosterone	67-79	interleukin 1 beta	Homo sapiens	45-62
17192399-8	2007	Activation of the P2X(7)R by extracellular ATP causes IL-1beta release from the vesicle lumen.	Adenosine Triphosphate	43-46	interleukin 1 beta	Homo sapiens	54-62
17224841-4	2007	Polymethylmethacrylate elicited a six- to 12-fold increase in gene expression of tumor necrosis factor alpha, interleukin 1alpha, interleukin 1beta, interleukin 6, and interleukin 8 in purified monocytes and unfractionated peripheral blood mononuclear cells.	Polymethyl Methacrylate	0-22	interleukin 1 beta	Homo sapiens	130-147
17470620-6	2007	However, histamine increased IL-1beta-induced GM-CSF release and markedly reduced TNF-alpha-induced RANTES release by both asthmatic and nonasthmatic cells to a similar extent, but did not modulate PGE(2) release.	Histamine	9-18	interleukin 1 beta	Homo sapiens	29-37
17533579-8	2007	CONCLUSION: Consequently this data implicates IL-1beta and IL-10 in the pathogenesis of CAD and suggests that testosterone may regulate IL-1beta activity in men with CAD.	Testosterone	110-122	interleukin 1 beta	Homo sapiens	46-54
17533579-8	2007	CONCLUSION: Consequently this data implicates IL-1beta and IL-10 in the pathogenesis of CAD and suggests that testosterone may regulate IL-1beta activity in men with CAD.	Testosterone	110-122	interleukin 1 beta	Homo sapiens	136-144
17369187-6	2007	NKR-P2 cross-linking with 1A6 also induced the secretion of inflammatory cytokines, IL-1beta, tumor necrosis factor-alpha, IFN-gamma and IL-12 by DCs.	3-{[(3-Methyl-1,2-Oxazol-5-Yl)methyl]sulfanyl}[1,2,4]triazolo[4,3-A]pyridine	26-29	interleukin 1 beta	Homo sapiens	84-121
17588137-5	2007	RESULTS: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells.	Quercetin	9-18	interleukin 1 beta	Homo sapiens	102-124
17306250-7	2007	The aim of this study was to determine the role of sensory nerves through the effect of the tachykinin NK3 receptor antagonist SR142801 in the interleukin-1beta effects and/or the NGF-induced airway hyperresponsiveness.	SR 142801	127-135	interleukin 1 beta	Homo sapiens	143-160
17390080-0	2007	Triptolide suppresses interleukin-1beta-induced human beta-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells.	triptolide	0-10	interleukin 1 beta	Homo sapiens	22-39
17390080-5	2007	In this study, we investigated effects of triptolide on IL-1beta-induced HBD-2 mRNA expression in A549 cells.	triptolide	42-52	interleukin 1 beta	Homo sapiens	56-64
17390080-6	2007	Triptolide inhibited IL-1beta-induced HBD-2 mRNA expression in a dose-dependent manner.	triptolide	0-10	interleukin 1 beta	Homo sapiens	21-29
17390080-8	2007	Triptolide inhibited IL-1beta-induced MAPK phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK, explaining the little effect of triptolide on IL-1beta-induced phosphorylation of these kinases.	triptolide	0-10	interleukin 1 beta	Homo sapiens	21-29
17390080-8	2007	Triptolide inhibited IL-1beta-induced MAPK phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK, explaining the little effect of triptolide on IL-1beta-induced phosphorylation of these kinases.	triptolide	0-10	interleukin 1 beta	Homo sapiens	205-213
17390080-9	2007	Although triptolide partially suppressed IL-1beta-mediated degradation of IkappaB-alpha and nuclear translocation of p65 NF-kappaB, triptolide potently inhibited NF-kappaB promoter-driven luciferase activity in A549 cells.	triptolide	9-19	interleukin 1 beta	Homo sapiens	41-49
17390080-10	2007	These results collectively suggest that the inhibitory effect of triptolide on IL-1beta-induced HBD-2 mRNA expression in A549 cells seems to be at least in part mediated through nuclear inhibition of NF-kappaB transcriptional activity, but not inhibition of p38 MAPK, JNK, or PI3K.	triptolide	65-75	interleukin 1 beta	Homo sapiens	79-87
17402996-11	2007	Rectal nitric oxide levels parallel down-regulation of inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin-1beta and interferon-gamma and may serve as a quantitative biomarker of intestinal inflammation.	Nitric Oxide	7-19	interleukin 1 beta	Homo sapiens	117-134
17404311-0	2007	Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release.	Aluminum Hydroxide	0-18	interleukin 1 beta	Homo sapiens	59-67
17853696-4	2007	Indometacin inhibited the effects induced by the bacterial endotoxin and interleukin-1beta.	Indomethacin	0-11	interleukin 1 beta	Homo sapiens	73-90
17289797-4	2007	We found that treatment with the H2S donor, sodium hydrosulfide, led to significant increases in the mRNA expression and protein production of TNF-alpha, IL-1beta, and IL-6 in U937 cells.	Hydrogen Sulfide	33-36	interleukin 1 beta	Homo sapiens	154-162
17289797-4	2007	We found that treatment with the H2S donor, sodium hydrosulfide, led to significant increases in the mRNA expression and protein production of TNF-alpha, IL-1beta, and IL-6 in U937 cells.	sodium bisulfide	44-63	interleukin 1 beta	Homo sapiens	154-162
17289797-7	2007	Furthermore, pretreatment of cells with Bay 11-7082 substantially inhibited the secretion of TNF-alpha, IL-1beta, and IL-6 induced by H2S.	3-(4-methylphenylsulfonyl)-2-propenenitrile	40-51	interleukin 1 beta	Homo sapiens	104-112
17289797-7	2007	Furthermore, pretreatment of cells with Bay 11-7082 substantially inhibited the secretion of TNF-alpha, IL-1beta, and IL-6 induced by H2S.	Hydrogen Sulfide	134-137	interleukin 1 beta	Homo sapiens	104-112
17322026-8	2007	Likewise, PS-1145 and ML120B profoundly reduced NF-kappaB-dependent transcription induced by IL-1beta and TNFalpha in primary HBE cells.	PS1145	10-17	interleukin 1 beta	Homo sapiens	93-101
17086212-2	2007	We recently reported that induction of a chemoresistant phenotype in the PDAC cell line PT45-P1 by long-term chemotherapy involves an increased interleukin 1 beta (IL1beta)-dependent secretion of nitric oxide (NO) accounting for efficient caspase inhibition.	Nitric Oxide	196-208	interleukin 1 beta	Homo sapiens	144-162
17086212-2	2007	We recently reported that induction of a chemoresistant phenotype in the PDAC cell line PT45-P1 by long-term chemotherapy involves an increased interleukin 1 beta (IL1beta)-dependent secretion of nitric oxide (NO) accounting for efficient caspase inhibition.	Nitric Oxide	196-208	interleukin 1 beta	Homo sapiens	164-171
17400256-8	2007	In vitro, HES suppressed the expression of IL-8 on A549 cells and THP-1 cells, the expression of TNF-alpha, IL-1 beta, and IL-6 on THP-1 cells, the expression of ICAM-1 and VCAM-1 on A549 cells which effect cell adhesion function.	Hesperidin	10-13	interleukin 1 beta	Homo sapiens	108-117
17400256-10	2007	HES inhibits those pathways, thereby suppressing the expression of IL-8, TNFalpha, IL-1 beta, IL-6, IL-12, ICAM-1 and VCAM-1.	Hesperidin	0-3	interleukin 1 beta	Homo sapiens	83-92
17429083-1	2007	BACKGROUND: The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, leading to impaired insulin secretion, decreased cell proliferation, and apoptosis.	Glucose	148-155	interleukin 1 beta	Homo sapiens	196-213
17306250-8	2007	SR142801 (0.1 microM) abolished the interleukin-1beta (10 ng/ml, 21 degrees C, 15 h)-induced increased NGF release from isolated human bronchi in vitro (P&lt;0.05).	SR 142801	0-8	interleukin 1 beta	Homo sapiens	36-53
17306250-9	2007	In organ bath studies, SR142801 also abolished the interleukin-1beta-induced airway hyperresponsiveness to [Sar(9),Met(O(2))(11)]SP (0.1 microM) (P&lt;0.05).	SR 142801	23-31	interleukin 1 beta	Homo sapiens	51-68
17306250-9	2007	In organ bath studies, SR142801 also abolished the interleukin-1beta-induced airway hyperresponsiveness to [Sar(9),Met(O(2))(11)]SP (0.1 microM) (P&lt;0.05).	TFF2 protein, human	129-131	interleukin 1 beta	Homo sapiens	51-68
17222322-6	2007	Serum beta-CTx correlated negatively with serum PIIINP and proinflammatory cytokines (IL-2, IL-6, IL-8, TNF-alpha), and positively with anti-inflammatory cytokines (IL-1, TGF-beta), whereas serum PIIINP correlated positively with these proinflammatory cytokines and negatively with the anti-inflammatory cytokines.	beta-ctx	6-14	interleukin 1 beta	Homo sapiens	165-169
17135302-0	2007	ROS and NF-kappaB but not LXR mediate IL-1beta signaling for the downregulation of ATP-binding cassette transporter A1.	Reactive Oxygen Species	0-3	interleukin 1 beta	Homo sapiens	38-46
17135302-6	2007	In contrast, NF-kappaB inhibition by pyrrolidine dithiocarbamate and MG132 prevented the suppression of ABCA1 by IL-1beta.	pyrrolidine dithiocarbamic acid	37-64	interleukin 1 beta	Homo sapiens	113-121
17135302-6	2007	In contrast, NF-kappaB inhibition by pyrrolidine dithiocarbamate and MG132 prevented the suppression of ABCA1 by IL-1beta.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	69-74	interleukin 1 beta	Homo sapiens	113-121
17135302-9	2007	In addition, IL-1beta could induce the production of reactive oxygen species (ROS), and N-acetyl-L-cysteine, a scavenger of ROS, reversed the decreased level of ABCA1 induced by IL-1beta.	Reactive Oxygen Species	53-76	interleukin 1 beta	Homo sapiens	13-21
17135302-9	2007	In addition, IL-1beta could induce the production of reactive oxygen species (ROS), and N-acetyl-L-cysteine, a scavenger of ROS, reversed the decreased level of ABCA1 induced by IL-1beta.	Reactive Oxygen Species	78-81	interleukin 1 beta	Homo sapiens	13-21
17135302-9	2007	In addition, IL-1beta could induce the production of reactive oxygen species (ROS), and N-acetyl-L-cysteine, a scavenger of ROS, reversed the decreased level of ABCA1 induced by IL-1beta.	Acetylcysteine	88-107	interleukin 1 beta	Homo sapiens	178-186
17135302-9	2007	In addition, IL-1beta could induce the production of reactive oxygen species (ROS), and N-acetyl-L-cysteine, a scavenger of ROS, reversed the decreased level of ABCA1 induced by IL-1beta.	Reactive Oxygen Species	124-127	interleukin 1 beta	Homo sapiens	178-186
17135302-11	2007	Thus our data provide strong evidence that ROS and NF-kappaB, but not LXR, mediate the IL-1beta-induced downregulation of ABCA1 via a novel transcriptional mechanism, which might play an important role of proinflammation in the alteration of lipid metabolism.	Reactive Oxygen Species	43-46	interleukin 1 beta	Homo sapiens	87-95
17349082-0	2007	Ellagic acid inhibits IL-1beta-induced cell adhesion molecule expression in human umbilical vein endothelial cells.	Ellagic Acid	0-12	interleukin 1 beta	Homo sapiens	22-30
16984938-8	2007	A trend towards reduction was seen in IL1beta and TNFalpha mRNA expression in the prednisolone group, although CIs included the value for no effect.	Prednisolone	82-94	interleukin 1 beta	Homo sapiens	38-45
17234728-9	2007	The same result was obtained in VSMCs in which endogenous NO was produced by iNOS induced by interleukin (IL)-1beta.	vsmcs	32-37	interleukin 1 beta	Homo sapiens	93-115
17325654-6	2007	KEY RESULTS: Stimulation of cells for 24 h with interleukin-1beta (IL-1beta) is known to trigger increased PGE(2) formation which coincides with an induction of the mRNA for group-IIA-sPLA(2) and protein expression.	Prostaglandins E	107-110	interleukin 1 beta	Homo sapiens	48-65
17349082-6	2007	The production of reactive oxygen species by IL-1beta was dose-dependently suppressed by EA.	Reactive Oxygen Species	18-41	interleukin 1 beta	Homo sapiens	45-53
17325654-6	2007	KEY RESULTS: Stimulation of cells for 24 h with interleukin-1beta (IL-1beta) is known to trigger increased PGE(2) formation which coincides with an induction of the mRNA for group-IIA-sPLA(2) and protein expression.	Prostaglandins E	107-110	interleukin 1 beta	Homo sapiens	67-75
17359338-7	2007	Cadexomer and cadexomer iodine significantly increased the expression of IL-1 beta, IL-8, TNF-alpha and VEGF mRNA, while they did not affect that of IL-6, IL-10, IL-12 p 40 or bFGF mRNA.	Iodine	24-30	interleukin 1 beta	Homo sapiens	73-82
17378884-2	2007	The purposes of this molecular cross-sectional epidemiological study were to investigate relationships in a community sample between mean concentrations of IL-1beta and PGE(2) in gingival crevicular fluid (GCF) and (1) clinical periodontal signs and (2) risk factors of host inflammatory response and/or periodontal disease.	Prostaglandins E	169-172	interleukin 1 beta	Homo sapiens	156-164
16781858-4	2007	Pretreatment with 100 microM EPA and DHA significantly decreased lipopolysaccharide (LPS)-stimulated THP-1 macrophage tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta and IL-6 production (P&lt;.02), compared to control cells.	Eicosapentaenoic Acid	29-32	interleukin 1 beta	Homo sapiens	153-175
16781858-5	2007	Both EPA and DHA reduced TNF-alpha, IL-1beta and IL-6 mRNA expression.	Eicosapentaenoic Acid	5-8	interleukin 1 beta	Homo sapiens	36-44
17372023-8	2007	NF-kappaB inhibitors, pyrrolidine dithiocarbamate and curcumin, prevented the IL-1beta-induced increase in Caco-2 TJ permeability.	pyrrolidine dithiocarbamic acid	22-49	interleukin 1 beta	Homo sapiens	78-86
17372023-8	2007	NF-kappaB inhibitors, pyrrolidine dithiocarbamate and curcumin, prevented the IL-1beta-induced increase in Caco-2 TJ permeability.	Curcumin	54-62	interleukin 1 beta	Homo sapiens	78-86
16781858-4	2007	Pretreatment with 100 microM EPA and DHA significantly decreased lipopolysaccharide (LPS)-stimulated THP-1 macrophage tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta and IL-6 production (P&lt;.02), compared to control cells.	Docosahexaenoic Acids	37-40	interleukin 1 beta	Homo sapiens	153-175
16781858-5	2007	Both EPA and DHA reduced TNF-alpha, IL-1beta and IL-6 mRNA expression.	Docosahexaenoic Acids	13-16	interleukin 1 beta	Homo sapiens	36-44
16781858-7	2007	Furthermore, a low dose (25 microM) of DHA had a greater inhibitory effect than that of EPA on macrophage IL-1beta (P&lt;.01 and P&lt;.04, respectively) and IL-6 (P&lt;.003 and P&lt;.003, respectively) production following 0.01 and 0.1 microg/ml LPS stimulation.	Docosahexaenoic Acids	39-42	interleukin 1 beta	Homo sapiens	106-114
17391300-2	2007	Gene expression profile of synovial fibroblasts stimulated with IL-1beta was studied by oligonucleotide microarray analysis to elucidate candidate genes associated with intracapsular pathologic conditions of TMJ.	Oligonucleotides	88-103	interleukin 1 beta	Homo sapiens	64-72
16781858-7	2007	Furthermore, a low dose (25 microM) of DHA had a greater inhibitory effect than that of EPA on macrophage IL-1beta (P&lt;.01 and P&lt;.04, respectively) and IL-6 (P&lt;.003 and P&lt;.003, respectively) production following 0.01 and 0.1 microg/ml LPS stimulation.	Eicosapentaenoic Acid	88-91	interleukin 1 beta	Homo sapiens	106-114
17196670-0	2007	Does the vagus nerve mediate the effects of polyunsaturated fatty acid treatment on behavioral, neuroendocrine and cytokine changes elicited by exogenous interleukin-1beta challenge?	Fatty Acids, Unsaturated	44-70	interleukin 1 beta	Homo sapiens	154-171
17283078-6	2007	We demonstrate that PGE(2) represses interleukin-1beta-induced matrix metalloproteinase (MMP)-1 and that transient overexpression of NURR1 is sufficient to antagonize expression of this gene.	Dinoprostone	20-26	interleukin 1 beta	Homo sapiens	37-54
16920192-0	2007	Retinoic acid-induced CD38 antigen promotes leukemia cells attachment and interferon-gamma/interleukin-1beta-dependent apoptosis of endothelial cells: implications in the etiology of retinoic acid syndrome.	Tretinoin	0-13	interleukin 1 beta	Homo sapiens	91-108
16920192-4	2007	In the present study, we found that RA treatment induces the expression of interferon-gamma (IFN-gamma) and interleukin-1beta (IL-1beta) in peripheral blast cells from APL patients.	Tretinoin	36-38	interleukin 1 beta	Homo sapiens	108-125
16920192-4	2007	In the present study, we found that RA treatment induces the expression of interferon-gamma (IFN-gamma) and interleukin-1beta (IL-1beta) in peripheral blast cells from APL patients.	Tretinoin	36-38	interleukin 1 beta	Homo sapiens	127-135
17118622-4	2007	At the same time, we have also reported that augmented expression of HLA and CD80, and production of IL-1beta were up-regulated in THP-1 cells when treated with an allergen, 2,4-dinitrochlorobenzene (DNCB).	Dinitrochlorobenzene	174-198	interleukin 1 beta	Homo sapiens	101-109
17321592-5	2007	This is associated with a modulation of the expression of trophoblastic genes described to be directly involved in the control of EVCT invasiveness, such as GH-V (-20%), TGFbeta2 (-30%), PAPP-A (-60%) and IL1beta (+300%.).	evct	130-134	interleukin 1 beta	Homo sapiens	205-212
17118622-4	2007	At the same time, we have also reported that augmented expression of HLA and CD80, and production of IL-1beta were up-regulated in THP-1 cells when treated with an allergen, 2,4-dinitrochlorobenzene (DNCB).	Dinitrochlorobenzene	200-204	interleukin 1 beta	Homo sapiens	101-109
17328062-2	2007	METHODS: SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on interleukin-1beta (IL-1beta)-stimulated MMP production and collagen degradation.	LG 100268	78-83	interleukin 1 beta	Homo sapiens	87-104
17293063-6	2007	Genes up-regulated by selenium supplementation included TNF, IL1B, IL8, SOD2, CXCL2 and several other immunological and oxidative stress-related genes.	Selenium	22-30	interleukin 1 beta	Homo sapiens	61-65
17178797-7	2007	The release of interleukin 1beta (IL-1beta) and IL-12 was significantly increased from monocytes stimulated either by HF alone (P &lt; 0.05) or in the presence of VRC (P &lt; 0.01 and P &lt; 0.05, respectively).	Voriconazole	163-166	interleukin 1 beta	Homo sapiens	15-32
17178797-7	2007	The release of interleukin 1beta (IL-1beta) and IL-12 was significantly increased from monocytes stimulated either by HF alone (P &lt; 0.05) or in the presence of VRC (P &lt; 0.01 and P &lt; 0.05, respectively).	Voriconazole	163-166	interleukin 1 beta	Homo sapiens	34-42
16765356-7	2007	Furthermore, lysophosphatidylcholine (lysoPC), a product of Lp-PLA2 activity, induced an increase in several inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in a concentration-dependent manner.	Lysophosphatidylcholines	13-36	interleukin 1 beta	Homo sapiens	133-141
16765356-7	2007	Furthermore, lysophosphatidylcholine (lysoPC), a product of Lp-PLA2 activity, induced an increase in several inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in a concentration-dependent manner.	Lysophosphatidylcholines	38-44	interleukin 1 beta	Homo sapiens	133-141
17208222-2	2007	We found that thalidomide inhibited the interleukin-1beta (IL-1beta)-mediated induction of COX-2 protein and mRNA in Caco-2 cells.	Thalidomide	14-25	interleukin 1 beta	Homo sapiens	40-57
17208222-2	2007	We found that thalidomide inhibited the interleukin-1beta (IL-1beta)-mediated induction of COX-2 protein and mRNA in Caco-2 cells.	Thalidomide	14-25	interleukin 1 beta	Homo sapiens	59-67
17328062-2	2007	METHODS: SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on interleukin-1beta (IL-1beta)-stimulated MMP production and collagen degradation.	LG 100268	78-83	interleukin 1 beta	Homo sapiens	106-114
17328062-6	2007	RESULTS: LG268 treatment specifically antagonized the IL-1beta-mediated induction of MMP-1 and MMP-13 heterogeneous nuclear RNA, messenger RNA, and protein.	LG 100268	9-14	interleukin 1 beta	Homo sapiens	54-62
17328062-8	2007	LG268 treatment also prevented the in vitro degradation of a type I collagen matrix by IL-1beta-treated SW-1353 cells.	LG 100268	0-5	interleukin 1 beta	Homo sapiens	87-95
17328065-5	2007	RESULTS: PGE(2) formation and cyclooxygenase 2 (COX-2) protein expression were induced by IL-1beta and potentiated by kinins with affinity for the B1 or B2 receptors, resulting in PGE(2)-dependent enhancement of RANKL.	Prostaglandins E	9-12	interleukin 1 beta	Homo sapiens	90-98
17328065-5	2007	RESULTS: PGE(2) formation and cyclooxygenase 2 (COX-2) protein expression were induced by IL-1beta and potentiated by kinins with affinity for the B1 or B2 receptors, resulting in PGE(2)-dependent enhancement of RANKL.	Dinoprostone	9-15	interleukin 1 beta	Homo sapiens	90-98
17064252-6	2007	CRP was strongly correlated, and TNF-alpha, IL-1beta and IL-6 were moderately correlated, with UBMA scores.	ubma	95-99	interleukin 1 beta	Homo sapiens	44-52
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Calcium	149-156	interleukin 1 beta	Homo sapiens	84-92
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Calcimycin	167-173	interleukin 1 beta	Homo sapiens	84-92
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	106-137	interleukin 1 beta	Homo sapiens	84-92
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	139-142	interleukin 1 beta	Homo sapiens	84-92
17286808-8	2007	In addition, secretion of proinflammatory mediators such as the cytokines interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF alpha), IL-6 and IL-8 were inhibited in the presence of physiological doses of OMZ.	Oxymetazoline	216-219	interleukin 1 beta	Homo sapiens	74-91
17417942-0	2007	Dual effect of butyrate on IL-1beta--mediated intestinal epithelial cell inflammatory response.	Butyrates	15-23	interleukin 1 beta	Homo sapiens	27-35
17417942-4	2007	While NaBu significantly increased the IL-1beta -induction of genes like SAA2, C3, and IL-1alpha , other inflammatory genes like CXCL5, CXCL11, and IL-1beta were decreased.	sethoxydim	6-10	interleukin 1 beta	Homo sapiens	39-47
17417942-7	2007	In addition, transient treatment with IL-1beta was sufficient for subsequent induction of NaBu-upregulated and NaBu-unaffected classes of genes, while a continuous presence of IL-1beta was required for NaBu-downregulated gene expression.	sethoxydim	90-94	interleukin 1 beta	Homo sapiens	38-46
17417942-7	2007	In addition, transient treatment with IL-1beta was sufficient for subsequent induction of NaBu-upregulated and NaBu-unaffected classes of genes, while a continuous presence of IL-1beta was required for NaBu-downregulated gene expression.	sethoxydim	111-115	interleukin 1 beta	Homo sapiens	38-46
17417942-7	2007	In addition, transient treatment with IL-1beta was sufficient for subsequent induction of NaBu-upregulated and NaBu-unaffected classes of genes, while a continuous presence of IL-1beta was required for NaBu-downregulated gene expression.	sethoxydim	111-115	interleukin 1 beta	Homo sapiens	38-46
17188268-7	2007	However, protection by minocycline is associated with a selective anti-inflammatory response, in that microglial activation and interleukin-1beta expression are reduced, while neutrophil infiltration and expression of multiple cytokines are not affected.	Minocycline	23-34	interleukin 1 beta	Homo sapiens	128-145
17286808-8	2007	In addition, secretion of proinflammatory mediators such as the cytokines interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF alpha), IL-6 and IL-8 were inhibited in the presence of physiological doses of OMZ.	Oxymetazoline	216-219	interleukin 1 beta	Homo sapiens	93-101
17454250-4	2007	MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell viability decreased significantly (p &lt; .05) from 0.00005 to 0.05 mg/ml after 24 h. The proinflammatory mediators of inflammation cytokines interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, IL-10, and IL-1beta were also assessed.	monooxyethylene trimethylolpropane tristearate	0-3	interleukin 1 beta	Homo sapiens	286-294
17273796-0	2007	Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	38-46
17273796-4	2007	However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha-induced IL-1beta, IL-6, IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells.	Curcumin	32-40	interleukin 1 beta	Homo sapiens	140-148
17273796-6	2007	We found that curcumin inhibited the expression of TNF-alpha-induced IL-1beta, IL-6, and TNF-alpha, but not IL-8, in TNF-alpha-treated HaCaT cells as well as the TNF-alpha-induced cyclin E expression.	Curcumin	14-22	interleukin 1 beta	Homo sapiens	69-77
17454250-4	2007	MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell viability decreased significantly (p &lt; .05) from 0.00005 to 0.05 mg/ml after 24 h. The proinflammatory mediators of inflammation cytokines interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, IL-10, and IL-1beta were also assessed.	thiazolyl blue	5-65	interleukin 1 beta	Homo sapiens	286-294
17284521-9	2007	We propose that, in macrophages, ATP-induced interleukin-1beta processing occurs in the cytosol by a mechanism that resembles pyroptosis.	Adenosine Triphosphate	33-36	interleukin 1 beta	Homo sapiens	45-62
17133356-3	2007	The PKC inhibitor GF109203X (10 microM) inhibited IL-1beta-induced Cox-2 protein and RNA expression, which were also reduced by MAPK and nuclear factor kappaB (NF-kappaB) inhibitors.	bisindolylmaleimide I	18-27	interleukin 1 beta	Homo sapiens	50-58
17133451-7	2007	However, silica-ceramic suppressed the synthesis of cytokines involved in inflammation, in particular, the expression of IL-1beta and IL-6 was reduced at the transcriptional and translational levels.	Silicon Dioxide	9-15	interleukin 1 beta	Homo sapiens	121-129
17393271-10	2007	IL-1beta-positive cases in the LSCS group showed higher VAS scores for leg pain and higher RDQ scores.	lscs	31-35	interleukin 1 beta	Homo sapiens	0-8
17348820-5	2007	Beta-estradiol levels in women with primary infections showed significant negative correlations with cervical concentrations of IL-10, IL-1beta, and IL-6.	Estradiol	0-14	interleukin 1 beta	Homo sapiens	135-143
17341845-6	2007	The results showed that hemin can significantly decrease pro-inflammatory cytokines interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha levels, while enhancing IL-10 production in a dose-dependent manner in U937 foam cells.	Hemin	24-29	interleukin 1 beta	Homo sapiens	84-106
17335379-1	2007	BACKGROUND: In previous work, the cyclooxygenase-2 inhibitor NS-398 inhibited interleukin (IL)-1beta-stimulated prostaglandin E(2) (PGE(2)) production almost completely while partially inhibiting IL-6 production in aggressive periodontitis (AgP) human gingival fibroblasts.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	61-67	interleukin 1 beta	Homo sapiens	78-100
17335379-1	2007	BACKGROUND: In previous work, the cyclooxygenase-2 inhibitor NS-398 inhibited interleukin (IL)-1beta-stimulated prostaglandin E(2) (PGE(2)) production almost completely while partially inhibiting IL-6 production in aggressive periodontitis (AgP) human gingival fibroblasts.	Dinoprostone	112-130	interleukin 1 beta	Homo sapiens	78-100
17335379-1	2007	BACKGROUND: In previous work, the cyclooxygenase-2 inhibitor NS-398 inhibited interleukin (IL)-1beta-stimulated prostaglandin E(2) (PGE(2)) production almost completely while partially inhibiting IL-6 production in aggressive periodontitis (AgP) human gingival fibroblasts.	Prostaglandins E	132-135	interleukin 1 beta	Homo sapiens	78-100
17194798-8	2007	The level of NF-kappaB inhibition by irisolidone correlated with the level of iNOS, TNF-alpha, and interleukin (IL)-1beta suppression in LPS-stimulated microglia, whereas the level of ERK inhibition correlated with the level of TNF-alpha and IL-1beta repression.	irisolidone	37-48	interleukin 1 beta	Homo sapiens	99-121
17194798-8	2007	The level of NF-kappaB inhibition by irisolidone correlated with the level of iNOS, TNF-alpha, and interleukin (IL)-1beta suppression in LPS-stimulated microglia, whereas the level of ERK inhibition correlated with the level of TNF-alpha and IL-1beta repression.	irisolidone	37-48	interleukin 1 beta	Homo sapiens	242-250
17208929-4	2007	The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. Tissues obtained after labour (or after the activation of inflammatory processes leading to labour) were not inhibited by the low levels of oxygen, indicating that only before the onset of labour does oxygen regulate fetal membrane biology.	Dinoprostone	14-32	interleukin 1 beta	Homo sapiens	83-91
17414346-12	2007	Analysis of the cytokine expression profile in 20 patients in each group revealed that propranolol significantly decreased serum tumor necrosis factor and interleukin-1beta compared with controls (p &lt; 0.05).	Propranolol	87-98	interleukin 1 beta	Homo sapiens	155-172
17208929-4	2007	The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. Tissues obtained after labour (or after the activation of inflammatory processes leading to labour) were not inhibited by the low levels of oxygen, indicating that only before the onset of labour does oxygen regulate fetal membrane biology.	Oxygen	400-406	interleukin 1 beta	Homo sapiens	83-91
17335379-2	2007	PGE(2) and the transcription factor nuclear factor-kappa B (NF-kappaB) regulate IL-1beta-stimulated IL-6 production.	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	80-88
17335379-8	2007	Enzyme-linked immunosorbent assays were used to measure PGE(2) and IL-6 production by 2.5 x 10(4) cells after exposure to IL-1beta with or without NS-398 in serum-free medium.	Prostaglandins E	56-59	interleukin 1 beta	Homo sapiens	122-130
17335379-9	2007	RESULTS: Consistent with previous results, NS-398 reduced IL-1beta-stimulated PGE(2) by approximately 98% (P &lt;0.001) and IL-6 by approximately 65% (P &lt;0.001).	Prostaglandins E	78-81	interleukin 1 beta	Homo sapiens	58-66
17178924-6	2007	IL-1beta-, FBS-, or PMA-induced stabilization of B1 receptor mRNA was inhibited by the addition of the protein kinase C inhibitor 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride (GF-109203x), which also diminished the Bmax under FBS or PMA treatment.	Tetradecanoylphorbol Acetate	20-23	interleukin 1 beta	Homo sapiens	0-8
17178924-6	2007	IL-1beta-, FBS-, or PMA-induced stabilization of B1 receptor mRNA was inhibited by the addition of the protein kinase C inhibitor 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride (GF-109203x), which also diminished the Bmax under FBS or PMA treatment.	bisindolylmaleimide I	234-244	interleukin 1 beta	Homo sapiens	0-8
17208929-4	2007	The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. Tissues obtained after labour (or after the activation of inflammatory processes leading to labour) were not inhibited by the low levels of oxygen, indicating that only before the onset of labour does oxygen regulate fetal membrane biology.	Oxygen	461-467	interleukin 1 beta	Homo sapiens	83-91
16794572-0	2007	Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion.	Dopamine	82-90	interleukin 1 beta	Homo sapiens	54-62
17227815-6	2007	In contrast, IL-1beta-induced IL-8 production was significantly blocked by BAY11-7082, but not by C3 transferase exoenzyme or Y-27632.	3-(4-methylphenylsulfonyl)-2-propenenitrile	75-85	interleukin 1 beta	Homo sapiens	13-21
16794572-0	2007	Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion.	Corticosterone	178-192	interleukin 1 beta	Homo sapiens	54-62
16794572-0	2007	Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion.	Fatty Acids, Omega-3	0-18	interleukin 1 beta	Homo sapiens	54-62
16794572-0	2007	Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion.	eicosapentaenoic acid ethyl ester	19-42	interleukin 1 beta	Homo sapiens	54-62
16794572-2	2007	We have also demonstrated that n-3 fatty acid ethyl-eicosapentaenoate (EPA) can significantly reduce stress and anxiety-like behaviors, corticosterone concentrations [corrected] and peripheral inflammatory response induced by IL-1 administration.	n-3 fatty acid ethyl-eicosapentaenoate	31-69	interleukin 1 beta	Homo sapiens	226-230
16794572-2	2007	We have also demonstrated that n-3 fatty acid ethyl-eicosapentaenoate (EPA) can significantly reduce stress and anxiety-like behaviors, corticosterone concentrations [corrected] and peripheral inflammatory response induced by IL-1 administration.	eicosapentaenoic acid ethyl ester	71-74	interleukin 1 beta	Homo sapiens	226-230
16794572-6	2007	Using an in vivo microdialysis method, the present study showed that IL-1 administration significantly increased extracellular levels of DA, and its metabolites 3,4-dihydroxyphenylacetic acid, [corrected] and homovanillic acid [corrected] in the shell of the NAc.	Dopamine	137-139	interleukin 1 beta	Homo sapiens	69-73
16794572-6	2007	Using an in vivo microdialysis method, the present study showed that IL-1 administration significantly increased extracellular levels of DA, and its metabolites 3,4-dihydroxyphenylacetic acid, [corrected] and homovanillic acid [corrected] in the shell of the NAc.	3,4-Dihydroxyphenylacetic Acid	161-191	interleukin 1 beta	Homo sapiens	69-73
16794572-6	2007	Using an in vivo microdialysis method, the present study showed that IL-1 administration significantly increased extracellular levels of DA, and its metabolites 3,4-dihydroxyphenylacetic acid, [corrected] and homovanillic acid [corrected] in the shell of the NAc.	Homovanillic Acid	209-226	interleukin 1 beta	Homo sapiens	69-73
16794572-7	2007	IL-1 also increased blood concentration of corticosterone and PGE2, and increased the activities of cytosolic and secretory [corrected] PLA2.	Corticosterone	43-57	interleukin 1 beta	Homo sapiens	0-4
16794572-7	2007	IL-1 also increased blood concentration of corticosterone and PGE2, and increased the activities of cytosolic and secretory [corrected] PLA2.	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	0-4
16794572-8	2007	IL-1-induced changes were significantly attenuated by EPA treatment.	eicosapentaenoic acid ethyl ester	54-57	interleukin 1 beta	Homo sapiens	0-4
16794572-9	2007	Furthermore, glucocorticoid [corrected] receptor antagonist mifepristone (RU486) pretreatment significantly blocked IL-1-induced changes in DA and metabolites.	Mifepristone	60-72	interleukin 1 beta	Homo sapiens	116-120
16794572-9	2007	Furthermore, glucocorticoid [corrected] receptor antagonist mifepristone (RU486) pretreatment significantly blocked IL-1-induced changes in DA and metabolites.	Mifepristone	74-79	interleukin 1 beta	Homo sapiens	116-120
16794572-10	2007	Quinacrine, [corrected] a PLA2 antagonist significantly blocked IL-1-induced [corrected] increase in PGE2 and corticosterone concentrations.	Quinacrine	0-10	interleukin 1 beta	Homo sapiens	64-68
16794572-10	2007	Quinacrine, [corrected] a PLA2 antagonist significantly blocked IL-1-induced [corrected] increase in PGE2 and corticosterone concentrations.	Dinoprostone	101-105	interleukin 1 beta	Homo sapiens	64-68
16794572-10	2007	Quinacrine, [corrected] a PLA2 antagonist significantly blocked IL-1-induced [corrected] increase in PGE2 and corticosterone concentrations.	Corticosterone	110-124	interleukin 1 beta	Homo sapiens	64-68
16794572-11	2007	These results demonstrated the hypotheses that IL-1 effects may be via PLA2-PGE2-corticosterone pathway and EPA attenuated IL-1 effects may be through the suppression of PLA2 expression, which then reduced PGE2 synthesis and corticosterone secretion.	Dinoprostone	76-80	interleukin 1 beta	Homo sapiens	47-51
16794572-11	2007	These results demonstrated the hypotheses that IL-1 effects may be via PLA2-PGE2-corticosterone pathway and EPA attenuated IL-1 effects may be through the suppression of PLA2 expression, which then reduced PGE2 synthesis and corticosterone secretion.	Corticosterone	81-95	interleukin 1 beta	Homo sapiens	47-51
16794572-11	2007	These results demonstrated the hypotheses that IL-1 effects may be via PLA2-PGE2-corticosterone pathway and EPA attenuated IL-1 effects may be through the suppression of PLA2 expression, which then reduced PGE2 synthesis and corticosterone secretion.	eicosapentaenoic acid ethyl ester	108-111	interleukin 1 beta	Homo sapiens	123-127
17184753-4	2007	We show that a similar unilateral microinjection of IL1beta (10 ng) into layer VI or onto the surface of the primary somatosensory cortex induced increases in the neuronal activity marker, Fos, relative to the contralateral side that received saline or heat-inactivated IL1beta.	Sodium Chloride	243-249	interleukin 1 beta	Homo sapiens	52-59
17239863-5	2007	ICAM-1 and VCAM-1 expression stimulated by IL-1beta was reduced by the treatment with aspirin, whereas the expression of E-selectin was unaffected.	Aspirin	86-93	interleukin 1 beta	Homo sapiens	43-51
17239863-6	2007	Nuclear factor kappaB (NF-kappaB) activity was enhanced by IL-1beta and reduced by aspirin, indicating that decreased ICAM-1 and VCAM-1 expression was due to reduced NF-kappaB activity.Thus, aspirin inhibits the adhesion of Jurkat T cells to IL-1beta-activated AoSMC by reducing NF-kappaB activity and decreasing expression of ICAM-1 and VCAM-1, and may prevent the development of atherosclerosis.	Aspirin	191-198	interleukin 1 beta	Homo sapiens	59-67
17239863-6	2007	Nuclear factor kappaB (NF-kappaB) activity was enhanced by IL-1beta and reduced by aspirin, indicating that decreased ICAM-1 and VCAM-1 expression was due to reduced NF-kappaB activity.Thus, aspirin inhibits the adhesion of Jurkat T cells to IL-1beta-activated AoSMC by reducing NF-kappaB activity and decreasing expression of ICAM-1 and VCAM-1, and may prevent the development of atherosclerosis.	Aspirin	191-198	interleukin 1 beta	Homo sapiens	242-250
17239863-3	2007	Aspirin inhibited T-cell adhesion to AoSMC activated by interleukin 1beta (IL-1beta) in a dose-dependent manner.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	56-73
17239863-3	2007	Aspirin inhibited T-cell adhesion to AoSMC activated by interleukin 1beta (IL-1beta) in a dose-dependent manner.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	75-83
17132626-7	2007	In parallel, ATP-mediated ROS-dependent PI3K is required for activation of caspase-1 and secretion of IL-1beta and IL-18.	Adenosine Triphosphate	13-16	interleukin 1 beta	Homo sapiens	102-110
17132626-7	2007	In parallel, ATP-mediated ROS-dependent PI3K is required for activation of caspase-1 and secretion of IL-1beta and IL-18.	Reactive Oxygen Species	26-29	interleukin 1 beta	Homo sapiens	102-110
17464345-3	2007	Here we report a novel derivative of isoquinoline-1,3,4-trione that is highly potent in inhibiting caspase-1 activity in an irreversible and slow-binding manner, thus inhibiting cellular caspase-1 activity and the maturation of interleukin 1beta in U-937 cells.	isoquinoline-1,3,4-trione	37-62	interleukin 1 beta	Homo sapiens	228-245
17284733-7	2007	RESULTS: IL-6, IL-1beta, and TNF-alpha production by PBMCs and serum TNF-alpha concentrations were lower (P &lt; 0.05 and P &lt; 0.08, respectively) with the ALA diet than with the LA diet or AAD.	alpha-Linolenic Acid	158-161	interleukin 1 beta	Homo sapiens	15-23
17284733-10	2007	CONCLUSIONS: Increased intakes of dietary ALA elicit antiinflammatory effects by inhibiting IL-6, IL-1beta, and TNF-alpha production in cultured PBMCs.	alpha-Linolenic Acid	42-45	interleukin 1 beta	Homo sapiens	98-106
17115938-5	2007	In contrast, epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), dibutyryl cyclic AMP (db cAMP) and interleukin-1beta (IL-1beta) induced the conversion to reactive astrocytes with diminished sensitivity to NaHS.	sodium bisulfide	231-235	interleukin 1 beta	Homo sapiens	125-142
17115938-5	2007	In contrast, epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), dibutyryl cyclic AMP (db cAMP) and interleukin-1beta (IL-1beta) induced the conversion to reactive astrocytes with diminished sensitivity to NaHS.	sodium bisulfide	231-235	interleukin 1 beta	Homo sapiens	144-152
16958052-4	2007	In this study, we show that the in vitro pyrogen test (IPT), which measures the release of the inflammatory cytokine IL-1beta in fresh or cryopreserved human whole blood, can be used to assess the pyrogenic contamination of implantable medical devices.	isoprothiolane	55-58	interleukin 1 beta	Homo sapiens	117-125
17178391-8	2007	Selective inhibitors of p38(mapk) (SB203580) or of MEK1/2, the direct upstream activator of ERK1/2 (PD98059), reduced the synthesis of IL-1beta, TNFalpha, IL-6 and IL-8 induced by either the chaperonins or LPS.	SB 203580	35-43	interleukin 1 beta	Homo sapiens	135-143
17178391-8	2007	Selective inhibitors of p38(mapk) (SB203580) or of MEK1/2, the direct upstream activator of ERK1/2 (PD98059), reduced the synthesis of IL-1beta, TNFalpha, IL-6 and IL-8 induced by either the chaperonins or LPS.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	100-107	interleukin 1 beta	Homo sapiens	135-143
17158965-7	2007	IL-1beta activity is dependent on p38 mitogen-activated protein (MAPK) kinase, which was found to be phosphorylated in tissue specimens from patients with CNS-TB.	Terbium	159-161	interleukin 1 beta	Homo sapiens	0-8
17202418-1	2007	The effects of the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK506) on the IL-1beta-induced matrix metalloproteinase-9 (MMP-9) were investigated.	Cyclosporine	53-56	interleukin 1 beta	Homo sapiens	88-96
17202418-1	2007	The effects of the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK506) on the IL-1beta-induced matrix metalloproteinase-9 (MMP-9) were investigated.	Tacrolimus	62-72	interleukin 1 beta	Homo sapiens	88-96
17202418-1	2007	The effects of the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK506) on the IL-1beta-induced matrix metalloproteinase-9 (MMP-9) were investigated.	Tacrolimus	74-79	interleukin 1 beta	Homo sapiens	88-96
17202418-3	2007	It is demonstrated that CsA, in contrast to FK506, reduced the IL-1beta-induced MMP-9 content in conditioned media of mesangial cells, which coincides with a reduction in the cytokine-induced MMP-9 mRNA level.	Cyclosporine	24-27	interleukin 1 beta	Homo sapiens	63-71
17202418-5	2007	Moreover, CsA caused a dose-dependent inhibition on the IL-1beta-induced luciferase activity of a 1.3-kb MMP-9 promoter fragment.	Cyclosporine	10-13	interleukin 1 beta	Homo sapiens	56-64
17085450-0	2007	The anti-rheumatic gold salt aurothiomalate suppresses interleukin-1beta-induced hyaluronan accumulation by blocking HAS1 transcription and by acting as a COX-2 transcriptional repressor.	Hyaluronic Acid	81-91	interleukin 1 beta	Homo sapiens	55-72
17373542-1	2007	Benzylsulfanyl imidazole derivatives (Figure 1) have shown their ability to inhibit the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) from peripheral blood mononuclear cells or human whole blood.	benzylsulfanyl imidazole	0-24	interleukin 1 beta	Homo sapiens	143-160
17373542-1	2007	Benzylsulfanyl imidazole derivatives (Figure 1) have shown their ability to inhibit the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) from peripheral blood mononuclear cells or human whole blood.	benzylsulfanyl imidazole	0-24	interleukin 1 beta	Homo sapiens	162-170
17373542-7	2007	The optimal activities seem to be manifested by compounds in which 4-R, 5-R and 6-R are substituted respectively by OH (or SOCH3 and SO2CH3), Cl and OH for inhibition of TNF-alpha, whereas by SOCH3 (or SO2CH3 and OH), H and OH for inhibition of IL-1beta.	4-r	67-70	interleukin 1 beta	Homo sapiens	245-253
17373542-7	2007	The optimal activities seem to be manifested by compounds in which 4-R, 5-R and 6-R are substituted respectively by OH (or SOCH3 and SO2CH3), Cl and OH for inhibition of TNF-alpha, whereas by SOCH3 (or SO2CH3 and OH), H and OH for inhibition of IL-1beta.	5-r	72-75	interleukin 1 beta	Homo sapiens	245-253
17373542-7	2007	The optimal activities seem to be manifested by compounds in which 4-R, 5-R and 6-R are substituted respectively by OH (or SOCH3 and SO2CH3), Cl and OH for inhibition of TNF-alpha, whereas by SOCH3 (or SO2CH3 and OH), H and OH for inhibition of IL-1beta.	6-r	80-83	interleukin 1 beta	Homo sapiens	245-253
17373542-7	2007	The optimal activities seem to be manifested by compounds in which 4-R, 5-R and 6-R are substituted respectively by OH (or SOCH3 and SO2CH3), Cl and OH for inhibition of TNF-alpha, whereas by SOCH3 (or SO2CH3 and OH), H and OH for inhibition of IL-1beta.	so2ch3	133-139	interleukin 1 beta	Homo sapiens	245-253
17286914-7	2007	The combination of TBP and TRBP was able to obviously inhibit both respiratory burst of monocytes induced by TNF-alpha and IFN-gamma and transcription level of IL-1beta and IL-8 mRNA induced by TNF-alpha.	trbp	27-31	interleukin 1 beta	Homo sapiens	160-168
16837047-1	2007	Mammalian interleukin-1beta (IL-1beta) is produced as a biologically inactive precursor molecule, which is proteolytically cleaved to an active form by IL-1beta-converting enzyme (ICE) after the activation of P2X(7) receptor by extracellular ATP.	Adenosine Triphosphate	242-245	interleukin 1 beta	Homo sapiens	10-27
16837047-1	2007	Mammalian interleukin-1beta (IL-1beta) is produced as a biologically inactive precursor molecule, which is proteolytically cleaved to an active form by IL-1beta-converting enzyme (ICE) after the activation of P2X(7) receptor by extracellular ATP.	Adenosine Triphosphate	242-245	interleukin 1 beta	Homo sapiens	29-37
16942919-0	2007	Simvastatin stimulates macrophage interleukin-1beta secretion through an isoprenylation-dependent mechanism.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	34-51
16942919-3	2007	Simvastatin treatment did not inhibit AgLDL-induced macrophage lipid accumulation, but significantly increased the secretion of IL-1beta and IL-8 from macrophages, whilst inhibiting the secretion of tumor necrosis factor-alpha (TNF-alpha) and having no significant effect on IL-6 secretion.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	128-136
16942919-5	2007	Simvastatin-stimulated IL-1beta secretion from macrophages was inhibited by isoprenoids.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	23-31
16942919-5	2007	Simvastatin-stimulated IL-1beta secretion from macrophages was inhibited by isoprenoids.	Terpenes	76-87	interleukin 1 beta	Homo sapiens	23-31
16942919-6	2007	We therefore hypothesized that simvastatin stimulated IL-1beta secretion by affecting isoprenylation-dependent signaling pathways.	Simvastatin	31-42	interleukin 1 beta	Homo sapiens	54-62
17085450-12	2007	AuTM blocks the release of PGE2 and prevents the activation of NFkappaB, therefore blocking IL-1beta-induced hyaluronan accumulation and likely a series of other pro-inflammatory NFkappaB-dependent genes.	Dinoprostone	27-31	interleukin 1 beta	Homo sapiens	92-100
17085450-12	2007	AuTM blocks the release of PGE2 and prevents the activation of NFkappaB, therefore blocking IL-1beta-induced hyaluronan accumulation and likely a series of other pro-inflammatory NFkappaB-dependent genes.	Hyaluronic Acid	109-119	interleukin 1 beta	Homo sapiens	92-100
17114179-5	2007	Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta, and epidermal growth factor.	plastochromanol 8	13-30	interleukin 1 beta	Homo sapiens	156-173
17067555-0	2007	Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells.	tangeretin	0-10	interleukin 1 beta	Homo sapiens	22-30
17046175-5	2007	We found that IL-1beta increased the expression levels of cPLA(2) and COX-2, and also increased the secretion of PGE(2).	Prostaglandins E	113-116	interleukin 1 beta	Homo sapiens	14-22
17046175-10	2007	These results suggest that IL-1beta-induced catabolic action on tendon fibroblasts occurs via the upregulation of two key inflammatory mediators, cPLA(2) and COX-2, which are responsible for the synthesis of PGE(2).	Prostaglandins E	208-211	interleukin 1 beta	Homo sapiens	27-35
17067555-5	2007	Tangeretin exerts a much better inhibitory activity than nobiletin against IL-1beta-induced production of COX-2 in A549 cells, and it effectively represses the constitutively expressed COX-2 in H1299.	tangeretin	0-10	interleukin 1 beta	Homo sapiens	75-83
17067555-9	2007	COX-2 expression in response to IL-1beta was attenuated by pretreatment with SB203580, SP600125, and LY294002, but not with PD98059, suggesting the involvement of p38 MAPK, JNK, and PI3K in this response.	SB 203580	77-85	interleukin 1 beta	Homo sapiens	32-40
17067555-9	2007	COX-2 expression in response to IL-1beta was attenuated by pretreatment with SB203580, SP600125, and LY294002, but not with PD98059, suggesting the involvement of p38 MAPK, JNK, and PI3K in this response.	pyrazolanthrone	87-95	interleukin 1 beta	Homo sapiens	32-40
17067555-9	2007	COX-2 expression in response to IL-1beta was attenuated by pretreatment with SB203580, SP600125, and LY294002, but not with PD98059, suggesting the involvement of p38 MAPK, JNK, and PI3K in this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	interleukin 1 beta	Homo sapiens	32-40
17067555-10	2007	Pretreatment of cells with tangeretin inhibited IL-1beta-induced p38 MAPK, JNK, and AKT phosphorylation and the downstream activation of NF-kappaB.	tangeretin	27-37	interleukin 1 beta	Homo sapiens	48-56
17067555-11	2007	These results may reveal that the tangeretin inhibition of IL-1beta-induced COX-2 expression in A549 cells is, at least in part, mediated through suppression of NF-kappaB transcription factor as well as through suppression of the signaling proteins of p38 MAPK, JNK, and PI3K, but not of ERK.	tangeretin	34-44	interleukin 1 beta	Homo sapiens	59-67
16837651-6	2007	NS-398 also inhibited the enhancement of alpha-SMA expression by TGF-beta1, IL-1beta, and IL-6 in activated PSCs.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	76-84
17184586-0	2007	Triptolide suppresses IL-1beta-induced chemokine and stromelysin-1 gene expression in human colonic subepithelial myofibroblasts.	triptolide	0-10	interleukin 1 beta	Homo sapiens	22-30
17184586-7	2007	Triptolide inhibited these effects of IL-1beta in a dose-dependent manner.	triptolide	0-10	interleukin 1 beta	Homo sapiens	38-46
17184586-8	2007	Mechanistic studies revealed that triptolide markedly decreased IL-1beta -induced NF-kappa B DNA binding capacity and cytosolic amount of p-I kappa B-alpha.	triptolide	34-44	interleukin 1 beta	Homo sapiens	64-72
17184586-9	2007	These results showed that triptolide inhibited IL-1beta -induced chemokine and MMP-3 expression in SEMF through the NF-kappa B pathway.	triptolide	26-36	interleukin 1 beta	Homo sapiens	47-55
17184586-10	2007	CONCLUSION: Triptolide inhibited IL-1beta -induced chemokine and MMP-3 expression in SEMF by preventing the phosphorylation of I kappa B-alpha.	triptolide	12-22	interleukin 1 beta	Homo sapiens	33-41
17569223-6	2007	Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	89-97
17713007-6	2007	In addition, diGMPP treatment of macrophages resulted in enhanced synthesis of IL-12, TNF-alpha, and IL-1beta.	digmpp	13-19	interleukin 1 beta	Homo sapiens	101-109
17597500-6	2007	It showed that DHSMT inhibited the production of TNF-alpha, IL-1beta, and IL-6 induced by LPS in a dose-dependent manner (p &lt; 0.05).	dhsmt	15-20	interleukin 1 beta	Homo sapiens	60-68
17597500-7	2007	The maximal inhibition rates for TNF-alpha, IL-1beta, and IL-6 production by DHSMT were about 50.18%, 32.13%, and 38.03%, respectively.	dhsmt	77-82	interleukin 1 beta	Homo sapiens	44-52
17352828-1	2007	Monosodium urate crystals stimulate monocytes and macrophages to release IL-1beta through the NALP3 component of the inflammasome.	Uric Acid	0-16	interleukin 1 beta	Homo sapiens	73-81
17404069-0	2007	Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	21-30
17404069-4	2007	In this article we investigated whether resveratrol is able to block the effects of IL-1beta, specifically the activation of caspase-3 and subsequent cleavage of poly (ADP-ribose) polymerase (PARP) in human articular chondrocytes.	Resveratrol	40-51	interleukin 1 beta	Homo sapiens	84-92
17404069-6	2007	Resveratrol significantly reduced the IL-1beta-induced inhibition of expression of cartilage-specific collagen type II and signal transduction receptor beta1-integrin in a time-dependent manner.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	38-46
17404069-9	2007	Furthermore, co-treatment of IL-1beta-stimulated cells with the caspase inhibitor Z-DEVD-FMK blocked activation of caspase-3 and PARP cleavage, suggesting that this process is a caspase-dependent pathway.	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	82-92	interleukin 1 beta	Homo sapiens	29-37
17386086-11	2007	Similarly, inhibitors of NF-kappaB signaling (pyrrolidine dithiocarbamate, MG-132, and SN-50) abolished the suppressive effect of IL-1.	pyrrolidine dithiocarbamic acid	46-73	interleukin 1 beta	Homo sapiens	130-134
17386086-11	2007	Similarly, inhibitors of NF-kappaB signaling (pyrrolidine dithiocarbamate, MG-132, and SN-50) abolished the suppressive effect of IL-1.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	75-81	interleukin 1 beta	Homo sapiens	130-134
17386086-11	2007	Similarly, inhibitors of NF-kappaB signaling (pyrrolidine dithiocarbamate, MG-132, and SN-50) abolished the suppressive effect of IL-1.	SN-50	87-92	interleukin 1 beta	Homo sapiens	130-134
16905640-10	2007	Similarly, whereas diesel extract stimulated production of IL-8, granulocyte-macrophage colony-stimulating factor, and IL-1beta from primary human bronchial epithelial cells, sulforaphane pretreatment inhibited diesel-induced production of all of these cytokines.	sulforaphane	175-187	interleukin 1 beta	Homo sapiens	119-127
17012372-14	2007	In conclusion, TNF-alpha and IL-1beta induce an exaggerated inflammatory response in CF airway cells, inhibited by MXF more than by CIP or AZM.	Azithromycin	139-142	interleukin 1 beta	Homo sapiens	29-37
17668557-10	2007	Lopinavir, nelfinavir, zidovudine and stavudine markedly increased ROS production and release of IL-1 beta and tumour necrosis factor-alpha.	Lopinavir	0-9	interleukin 1 beta	Homo sapiens	97-139
17668557-10	2007	Lopinavir, nelfinavir, zidovudine and stavudine markedly increased ROS production and release of IL-1 beta and tumour necrosis factor-alpha.	Nelfinavir	11-21	interleukin 1 beta	Homo sapiens	97-139
17668557-10	2007	Lopinavir, nelfinavir, zidovudine and stavudine markedly increased ROS production and release of IL-1 beta and tumour necrosis factor-alpha.	Zidovudine	23-33	interleukin 1 beta	Homo sapiens	97-139
17668557-10	2007	Lopinavir, nelfinavir, zidovudine and stavudine markedly increased ROS production and release of IL-1 beta and tumour necrosis factor-alpha.	Stavudine	38-47	interleukin 1 beta	Homo sapiens	97-139
17683641-11	2007	Real-time PCR analysis of articular cartilage from five patients with OA revealed that PGE2 at 10 pg/ml suppressed the expression of matrix metalloproteinase (MMP)-13 and to a smaller extent MMP-1, as well as the proinflammatory cytokines IL-1beta and TNF-alpha and type X collagen (COL10A1), the last of these being a marker of chondrocyte hypertrophy.	Dinoprostone	87-91	interleukin 1 beta	Homo sapiens	239-247
17697361-0	2007	Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1beta stimulated fibroblast-like synoviocytes.	N-chlorotaurine	0-18	interleukin 1 beta	Homo sapiens	90-107
17697361-4	2007	The effects of TauCl on MMP expression in IL-1beta stimulated fibroblast-like synoviocytes (FLSs) were studied using the following techniques.	N-chlorotaurine	15-20	interleukin 1 beta	Homo sapiens	42-50
17160716-0	2007	Phytic acid modulates in vitro IL-8 and IL-6 release from colonic epithelial cells stimulated with LPS and IL-1beta.	Phytic Acid	0-11	interleukin 1 beta	Homo sapiens	107-115
16934544-0	2007	Different effects of raloxifene and estrogen on interleukin-1beta and interleukin-1 receptor antagonist production using in vitro and ex vivo studies.	Raloxifene Hydrochloride	21-31	interleukin 1 beta	Homo sapiens	48-65
17131461-0	2007	Benzo[d]isothiazol-3-yl-benzamidines: a class of protective agents on culture of human cartilage and chondrocytes stimulated by IL-1beta.	benzo[d]isothiazol-3-yl-benzamidines	0-36	interleukin 1 beta	Homo sapiens	128-136
17925024-11	2007	These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta-stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation.	Glucosamine	53-64	interleukin 1 beta	Homo sapiens	74-82
16904269-7	2007	Similarly, sodium salicylate (NaSal) also suppressed IL-1beta induced HAS1 activation.	Sodium Salicylate	11-28	interleukin 1 beta	Homo sapiens	53-61
16904269-10	2007	Such data indicate that the effect of IL-1beta on HAS1 is mediated by prostaglandins.	Prostaglandins	70-84	interleukin 1 beta	Homo sapiens	38-46
17160716-2	2007	The aim of this study was to examine the role of PA in immunologic function of intestinal epithelial cells by analyzing its effect on interleukin (IL)-8 and IL-6 secretion by colonocytes and its role in the response of these cells to bacterial lipopolysaccharides (LPS) and IL-1beta.	Phytic Acid	49-51	interleukin 1 beta	Homo sapiens	274-282
17160716-5	2007	PA had a suppressive effect on IL-8 basal release and it dose dependently reduced IL-8 secretion by colonocytes stimulated with LPS and IL-1beta.	Phytic Acid	0-2	interleukin 1 beta	Homo sapiens	136-144
17958722-9	2007	Serum NE activities and serum concentrations of IL-1beta, IL-6, and HMGB1 were significantly suppressed in the Sivelestat-treated group.	sivelestat	111-121	interleukin 1 beta	Homo sapiens	48-56
17160716-7	2007	PA was also an efficient down-regulator of IL-6 secretion stimulated by binary actions of LPS and IL-1beta.	Phytic Acid	0-2	interleukin 1 beta	Homo sapiens	98-106
16888805-4	2007	Here, we show that IL-1beta and TPA stimulated TNFalpha gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element.	Tetradecanoylphorbol Acetate	117-120	interleukin 1 beta	Homo sapiens	19-27
17448722-5	2007	In parallel, a short-term (2h) cell exposure to AAT/LPS significantly enhances LPS-induced NF kappaB (p50 and p65) activation in conjunction with increased TNFalpha, IL-1 beta and IL-8 release.	Deuterium	27-29	interleukin 1 beta	Homo sapiens	166-175
17623553-5	2007	Interleukin-1 beta (IL-1beta) protein levels of cells on modified TCPS decreased over time.	tcps	66-70	interleukin 1 beta	Homo sapiens	0-18
17623553-5	2007	Interleukin-1 beta (IL-1beta) protein levels of cells on modified TCPS decreased over time.	tcps	66-70	interleukin 1 beta	Homo sapiens	20-28
17623553-6	2007	IL-1beta expression of monocytes in the presence of IPNs peaked at 24 h and then decreased through 168 h. Ligand identity did not affect IL-1beta expression in either TCPS or IPN samples.	ipn	52-55	interleukin 1 beta	Homo sapiens	0-8
17623553-7	2007	Pretreatment with anti-integrin beta1 or beta3 antibody reduced IL-1beta levels from both TCPS and IPN samples in a ligand-independent manner, particularly at 24 h. Monocytic IL-1beta mRNA expression in IPN samples without antibody pretreatment was highest at 2 h and decreased over time.	tcps	90-94	interleukin 1 beta	Homo sapiens	64-72
17623553-7	2007	Pretreatment with anti-integrin beta1 or beta3 antibody reduced IL-1beta levels from both TCPS and IPN samples in a ligand-independent manner, particularly at 24 h. Monocytic IL-1beta mRNA expression in IPN samples without antibody pretreatment was highest at 2 h and decreased over time.	tcps	90-94	interleukin 1 beta	Homo sapiens	175-183
17623553-7	2007	Pretreatment with anti-integrin beta1 or beta3 antibody reduced IL-1beta levels from both TCPS and IPN samples in a ligand-independent manner, particularly at 24 h. Monocytic IL-1beta mRNA expression in IPN samples without antibody pretreatment was highest at 2 h and decreased over time.	ipn	99-102	interleukin 1 beta	Homo sapiens	64-72
17623553-7	2007	Pretreatment with anti-integrin beta1 or beta3 antibody reduced IL-1beta levels from both TCPS and IPN samples in a ligand-independent manner, particularly at 24 h. Monocytic IL-1beta mRNA expression in IPN samples without antibody pretreatment was highest at 2 h and decreased over time.	ipn	99-102	interleukin 1 beta	Homo sapiens	175-183
17623553-7	2007	Pretreatment with anti-integrin beta1 or beta3 antibody reduced IL-1beta levels from both TCPS and IPN samples in a ligand-independent manner, particularly at 24 h. Monocytic IL-1beta mRNA expression in IPN samples without antibody pretreatment was highest at 2 h and decreased over time.	ipn	203-206	interleukin 1 beta	Homo sapiens	64-72
17623553-7	2007	Pretreatment with anti-integrin beta1 or beta3 antibody reduced IL-1beta levels from both TCPS and IPN samples in a ligand-independent manner, particularly at 24 h. Monocytic IL-1beta mRNA expression in IPN samples without antibody pretreatment was highest at 2 h and decreased over time.	ipn	203-206	interleukin 1 beta	Homo sapiens	175-183
17038556-5	2007	We demonstrated that IL-1beta slightly increased Glut 1 translocation and basal glucose uptake in 3T3-L1 adipocytes.	Glucose	80-87	interleukin 1 beta	Homo sapiens	21-29
17038556-6	2007	Importantly, we found that prolonged IL-1beta treatment reduced the insulin-induced glucose uptake, whereas an acute treatment had no effect.	Glucose	84-91	interleukin 1 beta	Homo sapiens	37-45
16888805-4	2007	Here, we show that IL-1beta and TPA stimulated TNFalpha gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element.	Cyclic AMP	140-144	interleukin 1 beta	Homo sapiens	19-27
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	153-156	interleukin 1 beta	Homo sapiens	233-241
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	interleukin 1 beta	Homo sapiens	141-149
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	interleukin 1 beta	Homo sapiens	233-241
17295145-1	2007	PURPOSE: To examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on the disruption of the barrier function in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin-1beta (IL-1beta).	Berberine	35-44	interleukin 1 beta	Homo sapiens	210-227
16902417-7	2007	Only carboxylic acid-coated QDs significantly increased release of IL-1beta, IL-6, and IL-8.	Carboxylic Acids	5-20	interleukin 1 beta	Homo sapiens	67-75
17295145-5	2007	RESULTS: Berberine dose-dependently inhibited decreased TER and increased the permeability to HRP and SF in the cells stimulated with IL-1beta.	Berberine	9-18	interleukin 1 beta	Homo sapiens	134-142
17191021-5	2007	RESULTS: Resveratrol (1-100 microM) dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion, with approximately 45% inhibition at 50 microM resveratrol.	Resveratrol	9-20	interleukin 1 beta	Homo sapiens	63-71
17295145-6	2007	CONCLUSIONS: Berberine dose-dependently inhibited the disruption of the barrier function in the ARPE-19 cell line induced by IL-1beta.	Berberine	13-22	interleukin 1 beta	Homo sapiens	125-133
17191021-5	2007	RESULTS: Resveratrol (1-100 microM) dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion, with approximately 45% inhibition at 50 microM resveratrol.	Resveratrol	147-158	interleukin 1 beta	Homo sapiens	63-71
18260853-10	2007	At the background of therapy with simvastatin we noted significant lowering of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6, IL-8) in blood serum irrespective of level of low density lipoprotein cholesterol, betterment of functional state of the left ventricle, positive clinical dynamics of CHF.	Simvastatin	34-45	interleukin 1 beta	Homo sapiens	116-124
17191021-8	2007	While resveratrol had no effect on MCP-1 mRNA degradation, it inhibited MCP-1 promoter activity and reduced nuclear factor kappaB and activator protein-1 binding activity induced by IL-1beta.	Resveratrol	6-17	interleukin 1 beta	Homo sapiens	182-190
16868182-1	2007	We have demonstrated that lipopolysaccharide (LPS)-mediated reactive oxygen species (ROS) and signal transduction are involved in the regulation of interleukin-1 (IL-1) beta gene expression within macrophages.	Reactive Oxygen Species	60-83	interleukin 1 beta	Homo sapiens	163-173
17030099-7	2007	Furthermore, ghrelin inhibits pro-inflammatory cytokines such as IL-1alpha, IL-1beta, TNF-alpha which may cause oral mucositis and aneroxia, which are the results of weight loss.	Ghrelin	13-20	interleukin 1 beta	Homo sapiens	76-84
17336462-6	2007	Previous studies showed that ghrelin has potent anti-inflammatory effect; inhibiting proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Ghrelin	29-36	interleukin 1 beta	Homo sapiens	160-177
17336462-6	2007	Previous studies showed that ghrelin has potent anti-inflammatory effect; inhibiting proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Ghrelin	29-36	interleukin 1 beta	Homo sapiens	179-187
17027041-3	2007	Human umbilical vein-derived ECs exhibited the increased activity in neutrophil activation, PAF synthesis, and GM-CSF production when stimulated by proinflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha).	Platelet Activating Factor	92-95	interleukin 1 beta	Homo sapiens	182-200
17027041-3	2007	Human umbilical vein-derived ECs exhibited the increased activity in neutrophil activation, PAF synthesis, and GM-CSF production when stimulated by proinflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha).	Platelet Activating Factor	92-95	interleukin 1 beta	Homo sapiens	202-211
16868182-1	2007	We have demonstrated that lipopolysaccharide (LPS)-mediated reactive oxygen species (ROS) and signal transduction are involved in the regulation of interleukin-1 (IL-1) beta gene expression within macrophages.	Reactive Oxygen Species	85-88	interleukin 1 beta	Homo sapiens	163-173
17377406-4	2007	The aim of the study was to compare the in vitro effect of vitamin A on the production of pro-inflammatory (IL-1beta and IL-6) and anti-inflammatory (IL-1 receptor antagonist (ra) and IL-10) cytokines, as well as IL-2 and IFNgamma by cord blood mononuclear cells (CBMC) of preterm newborns to that of peripheral blood mononuclear cells (PBMC) from adults.	Vitamin A	59-68	interleukin 1 beta	Homo sapiens	108-116
17105783-6	2007	IL-1beta stimulated release of PGE(2) by HMSM cells and increased COX-2 and mPGES-1 mRNA and protein expression.	Prostaglandins E	31-34	interleukin 1 beta	Homo sapiens	0-8
17377406-7	2007	RESULTS: Vitamin A exerted an in vitro inhibitory effect on the production of the anti-inflammatory cytokine IL-1ra by MC of preterm newborns and adults, but did not affect the secretion of the pro-inflammatory cytokines IL-1beta, IL-6 and IFNgamma.	Vitamin A	9-18	interleukin 1 beta	Homo sapiens	221-229
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	fisetin	0-7	interleukin 1 beta	Homo sapiens	174-196
17027275-8	2007	Since IL-1ra decreased the number of dopaminergic neurons in H2O2-treated cultures, we propose that IL-1 has a neuroprotective role in this system involving GDNF up-regulation.	Hydrogen Peroxide	61-65	interleukin 1 beta	Homo sapiens	6-10
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	interleukin 1 beta	Homo sapiens	174-196
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Calcimycin	73-79	interleukin 1 beta	Homo sapiens	174-196
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	pmaci	81-86	interleukin 1 beta	Homo sapiens	174-196
17207362-4	2007	RESULTS: SB203580 obviously down-regulated the activities of p38 and cPLA(2), as well as the release of IL-1 beta and IL-6.	SB 203580	9-17	interleukin 1 beta	Homo sapiens	104-113
17244328-4	2007	This study focused on: (1) the effects of PGE2 on keloid fibroblast migration, contraction, and collagen synthesis and (2) endogenous PGE2 synthesis in response interleukin-1beta.	Dinoprostone	134-138	interleukin 1 beta	Homo sapiens	161-178
17427275-9	2007	Pre-treatment with epinephrine or dopamine inhibited LPS-stimulated IL-1beta production significantly in the PBMCs from the healthy volunteers.	Epinephrine	19-30	interleukin 1 beta	Homo sapiens	68-76
17427275-9	2007	Pre-treatment with epinephrine or dopamine inhibited LPS-stimulated IL-1beta production significantly in the PBMCs from the healthy volunteers.	Dopamine	34-42	interleukin 1 beta	Homo sapiens	68-76
17172977-7	2007	The addition of NaCl lowered the production of IL-8, TNF-alpha, and IL-1 receptor antagonist by neutrophils, and IL-8 and IL-1beta by mononuclear cells stimulated with LPS.	Sodium Chloride	16-20	interleukin 1 beta	Homo sapiens	122-130
17518591-0	2007	Monocytic U937 adhesion, tumor necrosis factor-alpha and interleukin-1 beta expression in response to gelatin-based networks grafted with arginine-glycine-aspartic acid and proline-histidine-serine-arginine-asparagine oligopeptides.	arginine-glycine	138-154	interleukin 1 beta	Homo sapiens	57-75
17518591-0	2007	Monocytic U937 adhesion, tumor necrosis factor-alpha and interleukin-1 beta expression in response to gelatin-based networks grafted with arginine-glycine-aspartic acid and proline-histidine-serine-arginine-asparagine oligopeptides.	Aspartic Acid	155-168	interleukin 1 beta	Homo sapiens	57-75
17518591-0	2007	Monocytic U937 adhesion, tumor necrosis factor-alpha and interleukin-1 beta expression in response to gelatin-based networks grafted with arginine-glycine-aspartic acid and proline-histidine-serine-arginine-asparagine oligopeptides.	Proline	173-180	interleukin 1 beta	Homo sapiens	57-75
17518591-0	2007	Monocytic U937 adhesion, tumor necrosis factor-alpha and interleukin-1 beta expression in response to gelatin-based networks grafted with arginine-glycine-aspartic acid and proline-histidine-serine-arginine-asparagine oligopeptides.	Histidine	181-190	interleukin 1 beta	Homo sapiens	57-75
17142754-0	2006	Lysophosphatidylcholine stimulates IL-1beta release from microglia via a P2X7 receptor-independent mechanism.	Lysophosphatidylcholines	0-23	interleukin 1 beta	Homo sapiens	35-43
17179045-2	2006	In the case of interleukin-1beta (IL-1beta), four independent structures solved by x-ray crystallography indicate that water is not present in the central apolar cavity.	Water	119-124	interleukin 1 beta	Homo sapiens	15-32
17179045-2	2006	In the case of interleukin-1beta (IL-1beta), four independent structures solved by x-ray crystallography indicate that water is not present in the central apolar cavity.	Water	119-124	interleukin 1 beta	Homo sapiens	34-42
17067573-3	2006	Human monocytes were prepared from peripheral blood mononuclear cells obtained from healthy volunteers and pretreated with azelnidipine (1 microM) for 48 h, after which their adhesion to interleukin-1beta (IL-1beta)-activated human umbilical vein endothelial cells (HUVECs) was analyzed using an in vitro flow apparatus with a shear stress of 1 dyn/cm(2).	azelnidipine	123-135	interleukin 1 beta	Homo sapiens	187-204
17067573-3	2006	Human monocytes were prepared from peripheral blood mononuclear cells obtained from healthy volunteers and pretreated with azelnidipine (1 microM) for 48 h, after which their adhesion to interleukin-1beta (IL-1beta)-activated human umbilical vein endothelial cells (HUVECs) was analyzed using an in vitro flow apparatus with a shear stress of 1 dyn/cm(2).	azelnidipine	123-135	interleukin 1 beta	Homo sapiens	206-214
17142754-3	2006	Stimulation of LPS-preactivated microglia with lysophosphatidylcholine (LPC) caused rapid processing and secretion of mature 17-kDa IL-1beta.	Lysophosphatidylcholines	47-70	interleukin 1 beta	Homo sapiens	132-140
17142754-3	2006	Stimulation of LPS-preactivated microglia with lysophosphatidylcholine (LPC) caused rapid processing and secretion of mature 17-kDa IL-1beta.	Lysophosphatidylcholines	72-75	interleukin 1 beta	Homo sapiens	132-140
17142754-5	2006	Microglial LPC-induced IL-1beta release was suppressed in Ca(2+)-free medium or during inhibition of nonselective cation channels with Gd(3+) or La(3+).	Gadolinium	135-137	interleukin 1 beta	Homo sapiens	23-31
16896836-0	2006	Effect of meloxicam on gingival crevicular fluid IL-1beta and IL1 receptor antagonist levels in subjects with chronic periodontitis, and its effects on clinical parameters.	Meloxicam	10-19	interleukin 1 beta	Homo sapiens	49-57
17014957-0	2006	Alpha-MSH and gamma-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1beta differently.	Dinoprostone	63-67	interleukin 1 beta	Homo sapiens	86-94
17014957-1	2006	Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO).	Prostaglandins	135-149	interleukin 1 beta	Homo sapiens	0-17
17014957-1	2006	Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO).	Prostaglandins	135-149	interleukin 1 beta	Homo sapiens	19-27
17014957-1	2006	Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO).	Dinoprostone	151-155	interleukin 1 beta	Homo sapiens	0-17
17014957-1	2006	Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO).	Dinoprostone	151-155	interleukin 1 beta	Homo sapiens	19-27
17014957-1	2006	Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO).	Nitric Oxide	161-173	interleukin 1 beta	Homo sapiens	0-17
17014957-1	2006	Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO).	Nitric Oxide	161-173	interleukin 1 beta	Homo sapiens	19-27
17014957-3	2006	Our study investigated whether alpha-melanocyte stimulating hormone (alpha-MSH) and gamma-MSH could inhibit IL-1beta-induced PGE2 and NO release in hypothalamus in the rapid activation of the HPA axis.	Dinoprostone	125-129	interleukin 1 beta	Homo sapiens	108-116
17014957-5	2006	injection of 12.5 ng/microl of IL-1beta significantly increased the release of PGE2 and NOS activity in the hypothalamus.	Dinoprostone	79-83	interleukin 1 beta	Homo sapiens	31-39
17014957-6	2006	Treatment with alpha-MSH (0.1 microg/microl) inhibited the effect of IL-1beta on PGE2 release.	Dinoprostone	81-85	interleukin 1 beta	Homo sapiens	69-77
16792994-0	2006	Omega-3 fatty acids and decidual cell prostaglandin production in response to the inflammatory cytokine IL-1beta.	Fatty Acids, Omega-3	0-19	interleukin 1 beta	Homo sapiens	104-112
16792994-0	2006	Omega-3 fatty acids and decidual cell prostaglandin production in response to the inflammatory cytokine IL-1beta.	Prostaglandins	38-51	interleukin 1 beta	Homo sapiens	104-112
16792994-1	2006	OBJECTIVE: The objective of this study was to determine the effect of omega-3 fatty acids (eicosapentaenoic acid [EPA]; docosahexaenoic acid [DHA]) on prostaglandin production and prostanoid enzyme expression in cultured decidual cells exposed to interleukin-1beta (IL-1beta), a cytokine that plays a major role in inflammation.	Fatty Acids, Omega-3	70-89	interleukin 1 beta	Homo sapiens	247-264
16792994-1	2006	OBJECTIVE: The objective of this study was to determine the effect of omega-3 fatty acids (eicosapentaenoic acid [EPA]; docosahexaenoic acid [DHA]) on prostaglandin production and prostanoid enzyme expression in cultured decidual cells exposed to interleukin-1beta (IL-1beta), a cytokine that plays a major role in inflammation.	Fatty Acids, Omega-3	70-89	interleukin 1 beta	Homo sapiens	266-274
16792994-1	2006	OBJECTIVE: The objective of this study was to determine the effect of omega-3 fatty acids (eicosapentaenoic acid [EPA]; docosahexaenoic acid [DHA]) on prostaglandin production and prostanoid enzyme expression in cultured decidual cells exposed to interleukin-1beta (IL-1beta), a cytokine that plays a major role in inflammation.	Eicosapentaenoic Acid	91-112	interleukin 1 beta	Homo sapiens	247-264
16792994-1	2006	OBJECTIVE: The objective of this study was to determine the effect of omega-3 fatty acids (eicosapentaenoic acid [EPA]; docosahexaenoic acid [DHA]) on prostaglandin production and prostanoid enzyme expression in cultured decidual cells exposed to interleukin-1beta (IL-1beta), a cytokine that plays a major role in inflammation.	Eicosapentaenoic Acid	91-112	interleukin 1 beta	Homo sapiens	266-274
17052671-1	2006	We reported previously that a high molecular weight polysaccharide fraction (Immulina) from Spirulina was a potent activator of NF-kappa B and induced both IL-1 beta and TNF-alpha mRNAs in THP-1 human monocytes.	Polysaccharides	52-66	interleukin 1 beta	Homo sapiens	156-165
17031385-8	2006	ATP-evoked IL-1beta release from lipopolysaccharide-activated THP-1 cells was inhibited by AZ11645373, IC(50) = 90 nM.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	11-19
17031385-8	2006	ATP-evoked IL-1beta release from lipopolysaccharide-activated THP-1 cells was inhibited by AZ11645373, IC(50) = 90 nM.	AZ 11645373	91-101	interleukin 1 beta	Homo sapiens	11-19
16896836-1	2006	The aim of the present study was to determine the effects of meloxicam after initial periodontal treatment on interleukin-1beta (IL-1beta) and IL-1 receptor antagonist (IL-1ra) in gingival crevicular fluid (GCF) and clinical parameters in the chronic periodontitis patients.	Meloxicam	61-70	interleukin 1 beta	Homo sapiens	110-127
16896836-1	2006	The aim of the present study was to determine the effects of meloxicam after initial periodontal treatment on interleukin-1beta (IL-1beta) and IL-1 receptor antagonist (IL-1ra) in gingival crevicular fluid (GCF) and clinical parameters in the chronic periodontitis patients.	Meloxicam	61-70	interleukin 1 beta	Homo sapiens	129-137
16959838-9	2006	Treatment of hGL cells with IL-1beta increased the concentrations of both PGE2 and PGF2alpha, accompanied by a 70+/-25% increase in net cortisol oxidation.	Dinoprostone	74-78	interleukin 1 beta	Homo sapiens	28-36
17130210-7	2006	IL-1beta and -Ra levels correlated inversely (P &lt; 0.05) with rates of whole-body glucose uptake and IL-1beta positively with visceral fat mass (P &lt; 0.05) in normoglycemic offspring.	Glucose	84-91	interleukin 1 beta	Homo sapiens	0-8
16959838-9	2006	Treatment of hGL cells with IL-1beta increased the concentrations of both PGE2 and PGF2alpha, accompanied by a 70+/-25% increase in net cortisol oxidation.	Dinoprost	83-92	interleukin 1 beta	Homo sapiens	28-36
17008311-6	2006	Finally, cryopyrin was required for IL-1beta production in response to poly(I:C) in vivo.	Poly I-C	71-79	interleukin 1 beta	Homo sapiens	36-44
17050345-7	2006	Significant inductions of IL-1beta, TNF-alpha, and Cox-1 and Cox-2 mRNA were observed following exposure to &gt; or =50 ppm acetaldehyde for 4 h. IL-6 and MCP-1 were also induced following a 4-h exposure to 500 ppm acetaldehyde.	Acetaldehyde	124-136	interleukin 1 beta	Homo sapiens	26-34
17050345-7	2006	Significant inductions of IL-1beta, TNF-alpha, and Cox-1 and Cox-2 mRNA were observed following exposure to &gt; or =50 ppm acetaldehyde for 4 h. IL-6 and MCP-1 were also induced following a 4-h exposure to 500 ppm acetaldehyde.	Acetaldehyde	215-227	interleukin 1 beta	Homo sapiens	26-34
17233117-6	2006	Transient transfections with a reporter plasmid carrying the human IAP promoter showed significant inhibition of NaBu-induced IAP gene activation by the cytokines (100 and 60% inhibition with IL-1beta and TNF-alpha, respectively).	sethoxydim	113-117	interleukin 1 beta	Homo sapiens	192-200
17233117-9	2006	We conclude that IL-1beta and TNF-alpha inhibit NaBu-induced IAP gene expression, likely by blocking the histone acetylation within its promoter.	sethoxydim	48-52	interleukin 1 beta	Homo sapiens	17-25
17030574-1	2006	Gamma interferon (IFN-gamma)-induced indoleamine dioxygenase (IDO), which inhibits chlamydial replication by reducing the availability of tryptophan, is up-regulated by interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha).	Tryptophan	138-148	interleukin 1 beta	Homo sapiens	169-186
17030574-1	2006	Gamma interferon (IFN-gamma)-induced indoleamine dioxygenase (IDO), which inhibits chlamydial replication by reducing the availability of tryptophan, is up-regulated by interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha).	Tryptophan	138-148	interleukin 1 beta	Homo sapiens	188-196
16843534-6	2006	In contrast, secretion of the proinflammatory cytokine Il-1beta by U937 cells was decreased after phagocytosis of apoptotic trophoblasts and the changes in both IL-10 and IL-1beta secretion were blocked by co-incubation with the phagocytosis inhibitor cytochalasin B.	Cytochalasin B	252-266	interleukin 1 beta	Homo sapiens	55-63
17133340-9	2006	In the inflammation model, IL1beta/CIITApIV could drive hepatic luciferase expression increasedly rapidly after LPS challenge and in a LPS dose-dependent manner.	ciitapiv	35-43	interleukin 1 beta	Homo sapiens	27-34
17238806-7	2006	Glucosamine sulfate effectively downregulated the production of ICAM-1 induced by TNF-alpha, IFN-gamma, IL-1beta, TNF-alpha plus IFN-gamma, or TNF-alpha plus IL-1beta.	Glucosamine	0-19	interleukin 1 beta	Homo sapiens	104-112
17238806-7	2006	Glucosamine sulfate effectively downregulated the production of ICAM-1 induced by TNF-alpha, IFN-gamma, IL-1beta, TNF-alpha plus IFN-gamma, or TNF-alpha plus IL-1beta.	Glucosamine	0-19	interleukin 1 beta	Homo sapiens	158-166
17130267-10	2006	In addition to the hypolipidemic effect, atorvastatin treatment significantly reduced inflammatory parameters: CRP (median 4.1 to 2.9; P = 0.015), TNF-alpha (6.0 +/- 2.7 to 4.7 +/- 2.4; P = 0.046), and IL-1 beta levels (1.9 +/- 0.7 to 1.2 +/- 0.7; P = 0.001).	Atorvastatin	41-53	interleukin 1 beta	Homo sapiens	202-211
16934876-0	2006	Effects of acute or chronic omega-3 and omega-6 polyunsaturated fatty acid treatment on behavioral, neuroendocrine and cytokine changes elicited by exogenous interleukin-1beta challenge.	omega-3	28-35	interleukin 1 beta	Homo sapiens	158-175
16934876-0	2006	Effects of acute or chronic omega-3 and omega-6 polyunsaturated fatty acid treatment on behavioral, neuroendocrine and cytokine changes elicited by exogenous interleukin-1beta challenge.	omega-6 polyunsaturated fatty acid	40-74	interleukin 1 beta	Homo sapiens	158-175
16934876-1	2006	Chronic omega-3 or omega-6 polyunsaturated fatty acid (n-3; n-6 respectively) treatment attenuated human interleukin-1beta (hIL-1beta; 5.0 microg/kg)-elicited rise of circulating ACTH levels and attenuated the sickness behavior and locomotor suppression elicited by the cytokine.	omega-3	8-15	interleukin 1 beta	Homo sapiens	105-122
16934876-1	2006	Chronic omega-3 or omega-6 polyunsaturated fatty acid (n-3; n-6 respectively) treatment attenuated human interleukin-1beta (hIL-1beta; 5.0 microg/kg)-elicited rise of circulating ACTH levels and attenuated the sickness behavior and locomotor suppression elicited by the cytokine.	omega-3	8-15	interleukin 1 beta	Homo sapiens	124-133
16934876-1	2006	Chronic omega-3 or omega-6 polyunsaturated fatty acid (n-3; n-6 respectively) treatment attenuated human interleukin-1beta (hIL-1beta; 5.0 microg/kg)-elicited rise of circulating ACTH levels and attenuated the sickness behavior and locomotor suppression elicited by the cytokine.	omega-6 polyunsaturated fatty acid	19-53	interleukin 1 beta	Homo sapiens	105-122
16934876-1	2006	Chronic omega-3 or omega-6 polyunsaturated fatty acid (n-3; n-6 respectively) treatment attenuated human interleukin-1beta (hIL-1beta; 5.0 microg/kg)-elicited rise of circulating ACTH levels and attenuated the sickness behavior and locomotor suppression elicited by the cytokine.	omega-6 polyunsaturated fatty acid	19-53	interleukin 1 beta	Homo sapiens	124-133
16934876-4	2006	These results demonstrate that long-term administration of either n-3 or n-6 confers protection against several neuroendocrinological, immunological and behavioral actions of hIL-1beta challenge, although in general the effects of n-3 were more pronounced.	n-6	73-76	interleukin 1 beta	Homo sapiens	175-184
16940328-4	2006	The TREM-1/NLR synergism was observed for the production of TNF-alpha, IL-1beta, and IL-6, leading to an increase in cytokine production up to tenfold greater than the additive value of TREM-1 or muropeptide stimulation alone.	muropeptide	196-207	interleukin 1 beta	Homo sapiens	71-79
17238806-9	2006	Glucosamine sulfate further inhibited the nuclear translocation of p65 protein in TNF-alpha- and IL-1beta-stimulated Chang conjunctival cells and phosphorylated STAT1 in IFN-gamma-stimulated Chang conjunctival cells.	Glucosamine	0-19	interleukin 1 beta	Homo sapiens	97-105
17238806-10	2006	Glucosamine sulfate also significantly reduced the number of neutrophils adhering to a conjunctival monolayer in response to TNF-alpha, IFN-gamma, or IL-1beta.	Glucosamine	0-19	interleukin 1 beta	Homo sapiens	150-158
17085321-2	2006	Interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and lipopolysaccharide (LPS) all induced PGE(2) synthesis (p&lt;0.001) and transient (5-15 min) phosphorylation of extracellular signal-regulated kinase (ERK).	Prostaglandins E	99-102	interleukin 1 beta	Homo sapiens	0-22
17229988-0	2006	Production of prostacyclin and prostaglandin E2 in resting and IL-1beta-stimulated A549, HUVEC and hybrid EA.HY 926 cells.	Epoprostenol	14-26	interleukin 1 beta	Homo sapiens	63-71
17229988-0	2006	Production of prostacyclin and prostaglandin E2 in resting and IL-1beta-stimulated A549, HUVEC and hybrid EA.HY 926 cells.	Dinoprostone	31-47	interleukin 1 beta	Homo sapiens	63-71
17229988-3	2006	The aim of this study was to examine the production of prostacyclin and PGE2 in resting and IL-1beta-stimulated EA.ha 926 cells, in comparison with its progenitor cells.	Epoprostenol	55-67	interleukin 1 beta	Homo sapiens	92-100
17229988-3	2006	The aim of this study was to examine the production of prostacyclin and PGE2 in resting and IL-1beta-stimulated EA.ha 926 cells, in comparison with its progenitor cells.	Dinoprostone	72-76	interleukin 1 beta	Homo sapiens	92-100
17035941-5	2006	IL-1beta induced a time-dependent formation of VEGF (analyzed by enzyme-linked immunosorbent assay) and PGE2 (analyzed by enzyme immunoassay).	Dinoprostone	104-108	interleukin 1 beta	Homo sapiens	0-8
17146391-0	2006	Interleukin-1beta up-regulates inducible nitric oxide by way of phosphoinositide 3-kinase-dependent in a cochlear cell model.	Nitric Oxide	41-53	interleukin 1 beta	Homo sapiens	0-17
17146391-1	2006	OBJECTIVE: To investigate the effect of interleukin (IL)-1beta on inducible nitric oxide (iNOS) expression in cochlea and the molecular and signaling mechanisms involved.	Nitric Oxide	76-88	interleukin 1 beta	Homo sapiens	40-62
17146391-9	2006	Interestingly, pharmacologic inhibition of the PI3 K signaling pathway by LY294002 resulted in strong down-regulation of the IL-1beta-induced expressions of iNOS protein and mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	interleukin 1 beta	Homo sapiens	125-133
16988013-2	2006	In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 (Mol Endocrinol 11:1245-1255, 1997) repress interleukin (IL)-1beta-induced expression of cyclooxygenase (COX)-2 and IL-8.	Dexamethasone	25-38	interleukin 1 beta	Homo sapiens	131-153
16988013-2	2006	In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 (Mol Endocrinol 11:1245-1255, 1997) repress interleukin (IL)-1beta-induced expression of cyclooxygenase (COX)-2 and IL-8.	RU24858	79-86	interleukin 1 beta	Homo sapiens	131-153
16988013-6	2006	Analysis of IL-1beta-induced steady-state mRNA levels for IL-8 and COX-2 show that dexamethasone- and RU24858-dependent repression of these genes is attenuated by inhibitors of transcription and protein synthesis.	Dexamethasone	83-96	interleukin 1 beta	Homo sapiens	12-20
17097765-0	2006	Interleukin-1 beta-induced anorexia is reversed by ghrelin.	Ghrelin	51-58	interleukin 1 beta	Homo sapiens	0-18
17097765-3	2006	In the present study, we investigated if ghrelin could reverse IL-1beta-induced anorexia.	Ghrelin	41-48	interleukin 1 beta	Homo sapiens	63-71
17097765-9	2006	Central administration of ghrelin reduced the anorexic effect of IL-1beta (15 ng/microl).	Ghrelin	26-33	interleukin 1 beta	Homo sapiens	65-73
17097765-11	2006	This study provides evidence that ghrelin is an orexigenic peptide capable of antagonizing IL-1beta-induced anorexia.	Ghrelin	34-41	interleukin 1 beta	Homo sapiens	91-99
17054948-4	2006	Furthermore, expression of 2,3-sialylated N-acetyllactosamine increased gradually up to 48 h after IL-1 beta stimulation; this preceded the increase in sLeX expression.	N-acetyllactosamine	42-61	interleukin 1 beta	Homo sapiens	99-108
16723122-6	2006	Finally, we critically review the recent data highlighting the role of ROS in NF-kappaB activation by proinflammatory cytokines (TNF-alpha and IL-1beta) and lipopolysaccharide (LPS), two major components of innate immunity.	Reactive Oxygen Species	71-74	interleukin 1 beta	Homo sapiens	143-151
16884695-6	2006	Thus, activation of histamine H(1)-receptor-protein kinase C-mitogen-activated protein kinase signalling pathway plays a crucial role not only in the direct stimulation of NGF secretion by histamine, but also in the indirect stimulation via different types of interactions between histamine, interleukin-1beta, and interleukin-6, which may have important therapeutic implications in modulation of NGF production.	Histamine	20-29	interleukin 1 beta	Homo sapiens	292-309
17026971-0	2006	Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells.	Acetylcholine	49-62	interleukin 1 beta	Homo sapiens	15-32
16836488-8	2006	The role of GSTA1-1 in JNK suppression was more specifically revealed in Tet-Off-inducible MEF3T3-GSTA1-1 cells in which GSTA1 overexpression significantly reduced phosphorylation of c-Jun following exposure to IL-1beta, H2O2 and UV irradiation.	tetramethylenedisulfotetramine	73-76	interleukin 1 beta	Homo sapiens	211-219
17082635-5	2006	IL-1beta and TNF-alpha rapidly activated p50 and p65, but not C-Rel, RelB, or p52, and both IL-1beta- and TNF-alpha-stimulated A2AR expression was inhibited by the IkappaB kinase 2 inhibitor AS602868 in a concentration-dependent manner.	AS602868	191-199	interleukin 1 beta	Homo sapiens	0-8
17082635-5	2006	IL-1beta and TNF-alpha rapidly activated p50 and p65, but not C-Rel, RelB, or p52, and both IL-1beta- and TNF-alpha-stimulated A2AR expression was inhibited by the IkappaB kinase 2 inhibitor AS602868 in a concentration-dependent manner.	AS602868	191-199	interleukin 1 beta	Homo sapiens	92-100
17075828-3	2006	The goal of our study was to determine whether a temporary shortage of certain isoprenoid end products and/or the accumulation of mevalonic acid is the cause of interleukin-1beta (IL-1beta) secretion in MKD.	Terpenes	79-89	interleukin 1 beta	Homo sapiens	161-178
16760261-3	2006	In this study, LPA production and response were characterized in a human corneal epithelial cell line, 2.040 pRSV-T. LPA levels in cells and medium are increased by exogenous 18:1 LPA (oleoyl-LPA), LPS, IL-1beta, and TNF-alpha.	lysophosphatidic acid	15-18	interleukin 1 beta	Homo sapiens	203-211
16760261-3	2006	In this study, LPA production and response were characterized in a human corneal epithelial cell line, 2.040 pRSV-T. LPA levels in cells and medium are increased by exogenous 18:1 LPA (oleoyl-LPA), LPS, IL-1beta, and TNF-alpha.	lysophosphatidic acid	117-120	interleukin 1 beta	Homo sapiens	203-211
16760261-3	2006	In this study, LPA production and response were characterized in a human corneal epithelial cell line, 2.040 pRSV-T. LPA levels in cells and medium are increased by exogenous 18:1 LPA (oleoyl-LPA), LPS, IL-1beta, and TNF-alpha.	lysophosphatidic acid	117-120	interleukin 1 beta	Homo sapiens	203-211
17075828-3	2006	The goal of our study was to determine whether a temporary shortage of certain isoprenoid end products and/or the accumulation of mevalonic acid is the cause of interleukin-1beta (IL-1beta) secretion in MKD.	Terpenes	79-89	interleukin 1 beta	Homo sapiens	180-188
17075828-3	2006	The goal of our study was to determine whether a temporary shortage of certain isoprenoid end products and/or the accumulation of mevalonic acid is the cause of interleukin-1beta (IL-1beta) secretion in MKD.	Mevalonic Acid	130-144	interleukin 1 beta	Homo sapiens	161-178
17075828-3	2006	The goal of our study was to determine whether a temporary shortage of certain isoprenoid end products and/or the accumulation of mevalonic acid is the cause of interleukin-1beta (IL-1beta) secretion in MKD.	Mevalonic Acid	130-144	interleukin 1 beta	Homo sapiens	180-188
17075828-4	2006	METHODS: We studied the effect of the addition of intermediate metabolites and inhibitors of the isoprenoid biosynthesis pathway on IL-1beta secretion by peripheral blood mononuclear cells (PBMCs) of patients with MKD and healthy controls.	Terpenes	97-107	interleukin 1 beta	Homo sapiens	132-140
17075828-5	2006	RESULTS: Inhibition of enzymes involved in geranylgeranyl pyrophosphate (GGPP) synthesis or geranylgeranylation of proteins led to a marked increase of lipopolysaccharide-stimulated IL-1beta secretion in PBMCs of control subjects.	geranylgeranyl pyrophosphate	43-71	interleukin 1 beta	Homo sapiens	182-190
17075828-5	2006	RESULTS: Inhibition of enzymes involved in geranylgeranyl pyrophosphate (GGPP) synthesis or geranylgeranylation of proteins led to a marked increase of lipopolysaccharide-stimulated IL-1beta secretion in PBMCs of control subjects.	geranylgeranyl pyrophosphate	73-77	interleukin 1 beta	Homo sapiens	182-190
17075828-6	2006	Furthermore, the increased IL-1beta secretion by PBMCs of patients with MKD was reversed by supplementation with GGPP as well as with mevalonic acid.	geranylgeranyl pyrophosphate	113-117	interleukin 1 beta	Homo sapiens	27-35
17045449-5	2006	Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not.	Fatty Acids, Omega-3	0-19	interleukin 1 beta	Homo sapiens	61-78
17075828-6	2006	Furthermore, the increased IL-1beta secretion by PBMCs of patients with MKD was reversed by supplementation with GGPP as well as with mevalonic acid.	Mevalonic Acid	134-148	interleukin 1 beta	Homo sapiens	27-35
17045449-5	2006	Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not.	Fatty Acids, Omega-3	0-19	interleukin 1 beta	Homo sapiens	80-88
17075828-7	2006	IL-1beta secretion was increased only when control PBMCs were incubated with excessive amounts of mevalonic acid.	Mevalonic Acid	98-112	interleukin 1 beta	Homo sapiens	0-8
17075828-8	2006	Finally, a reduction in IL-1beta secretion by MKD PBMCs was also observed when sterol biosynthesis was inhibited, favoring nonsterol isoprenoid biosynthesis.	Sterols	79-85	interleukin 1 beta	Homo sapiens	24-32
17075828-8	2006	Finally, a reduction in IL-1beta secretion by MKD PBMCs was also observed when sterol biosynthesis was inhibited, favoring nonsterol isoprenoid biosynthesis.	Terpenes	133-143	interleukin 1 beta	Homo sapiens	24-32
17075836-8	2006	SMV prevented the increase in NF-kappaB activation and rise in IL-1beta and IL-6 levels induced by TNFalpha, whereas mevalonate and geranylgeranyl pyrophosphate reversed the inhibitory effects of SMV on activation of NF-kappaB and RhoA.	Simvastatin	0-3	interleukin 1 beta	Homo sapiens	63-71
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	82-113	interleukin 1 beta	Homo sapiens	0-22
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	115-118	interleukin 1 beta	Homo sapiens	0-22
16887914-0	2006	Interleukin-1beta signals through a c-Jun N-terminal kinase-dependent inducible nitric oxide synthase and nitric oxide production pathway in Sertoli epithelial cells.	Nitric Oxide	80-92	interleukin 1 beta	Homo sapiens	0-17
17002607-8	2006	After 50 mg or 100 mg HE2000, but not after placebo, there were significant sustained decreases in IL-1beta, TNF-alpha, IL-6 and Cox-2 transcripts (p &lt; 0.05).	16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one	22-28	interleukin 1 beta	Homo sapiens	99-107
16887914-3	2006	This study was designed to evaluate whether IL-1beta mediates high-output inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production in these specialized epithelial cells and characterize gonadotropin and cytokine-regulation of NO.	Nitric Oxide	84-96	interleukin 1 beta	Homo sapiens	44-52
16822504-8	2006	GS also inhibited the nuclear translocation of NF-kappaB subunit p65 and partially prevented the degradation of cytoplasmic IkappaB in IL-1beta-stimulated ARPE-19 cells.	Glucosamine	0-2	interleukin 1 beta	Homo sapiens	135-143
16822504-2	2006	We investigated whether glucosamine sulfate (GS) modulates the proinflammatory cytokine interleukin (IL)-1beta-induced expression and production of intercellular adhesion molecule (ICAM)-1, the mechanism responsible for this effect, and whether GS inhibits leukocyte adhesion to the monolayer of retinal pigment epithelial (RPE) cells stimulated with various cytokines.	Glucosamine	24-43	interleukin 1 beta	Homo sapiens	88-110
16822504-2	2006	We investigated whether glucosamine sulfate (GS) modulates the proinflammatory cytokine interleukin (IL)-1beta-induced expression and production of intercellular adhesion molecule (ICAM)-1, the mechanism responsible for this effect, and whether GS inhibits leukocyte adhesion to the monolayer of retinal pigment epithelial (RPE) cells stimulated with various cytokines.	Glucosamine	45-47	interleukin 1 beta	Homo sapiens	88-110
16822504-10	2006	GS inhibits the expression of the ICAM-1 gene in ARPE-19 cells stimulated with IL-1beta by blocking NF-kappaB subunit p65 translocation and by partially preventing IkappaB degradation.	Glucosamine	0-2	interleukin 1 beta	Homo sapiens	79-87
16822504-3	2006	We used flow cytometry and an ARPE-19 cell model to determine the effect of GS on the production of ICAM-1 in response to IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha plus IL-1beta, TNF-alpha plus IL-6, and TNF-alpha plus interferon (IFN)-gamma.	Glucosamine	76-78	interleukin 1 beta	Homo sapiens	122-130
17122964-0	2006	The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha.	Leflunomide	25-36	interleukin 1 beta	Homo sapiens	117-125
17122966-0	2006	Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha.	Superoxides	0-10	interleukin 1 beta	Homo sapiens	101-118
17122966-1	2006	OBJECTIVES: to evaluate the rheumatoid synovial cell capacity to produce superoxide anion in response to interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha), and to study the NADPH oxidase involvement in this production.	Superoxides	73-89	interleukin 1 beta	Homo sapiens	105-122
17122966-1	2006	OBJECTIVES: to evaluate the rheumatoid synovial cell capacity to produce superoxide anion in response to interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha), and to study the NADPH oxidase involvement in this production.	Superoxides	73-89	interleukin 1 beta	Homo sapiens	124-132
16772530-7	2006	Using chromatin immunoprecipitation, we observed that IL-1beta stimulated recruitment of NF-kappaB p65 to both proximal and distal NF-kappaB elements of the COX-2 promoter; these effects were diminished by coincubation with progesterone.	Progesterone	224-236	interleukin 1 beta	Homo sapiens	54-62
16965524-8	2006	IL-1alpha, IL-1beta and IL-8, but not IL-6, were detected in GCF of CsA-treated patients, but none of them was significantly associated with gingival overgrowth.	Cyclosporine	68-71	interleukin 1 beta	Homo sapiens	11-19
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	interleukin 1 beta	Homo sapiens	210-232
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	tert-butyldimethylsilyl chloride	55-59	interleukin 1 beta	Homo sapiens	210-232
17036048-0	2006	Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.	Adenosine Triphosphate	78-81	interleukin 1 beta	Homo sapiens	45-62
17036048-3	2006	Here, we identify pannexin-1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, as this dye-uptake pathway and show that signalling through pannexin-1 is required for processing of caspase-1 and release of mature IL-1beta induced by P2X(7) receptor activation.	hemichannel	89-100	interleukin 1 beta	Homo sapiens	262-270
16786194-0	2006	TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.	ferrous sulfate	150-155	interleukin 1 beta	Homo sapiens	26-34
16894392-5	2006	The increased production of proinflammatory cytokines such as IL-1beta, TNF-alpha or IL-18 resulting from stroke may lead to an amplification of the inflammatory process, particularly in limbic areas, and widespread activation of indoleamine 2,3-dioxygenase (IDO) and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex, polar temporal cortex and basal ganglia.	Serotonin	297-306	interleukin 1 beta	Homo sapiens	62-70
16786194-0	2006	TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.	Ascorbic Acid	161-170	interleukin 1 beta	Homo sapiens	26-34
16434095-5	2006	Treatment of placenta, amnion and choriodecidua with both 15d-PGJ(2) and troglitazone decreased basal and LPS-stimulated IL-1beta, IL-6, IL-10 and TNF-alpha release.	15d-pgj	58-65	interleukin 1 beta	Homo sapiens	121-129
17081047-2	2006	Polyvinyl alcohol addition to print buffers produced the most regular spot morphologies, homogeneous intra-spot antibody distribution, uniform fluorescence intensity, and improved analyte capture activity, maintained up to 1 month at 4 degrees C for capturing model analytes, anti-human IL-1beta, IL-4, and TNFalpha, on these microarraying slides.	Polyvinyl Alcohol	0-17	interleukin 1 beta	Homo sapiens	287-295
16434095-5	2006	Treatment of placenta, amnion and choriodecidua with both 15d-PGJ(2) and troglitazone decreased basal and LPS-stimulated IL-1beta, IL-6, IL-10 and TNF-alpha release.	Troglitazone	73-85	interleukin 1 beta	Homo sapiens	121-129
17068631-0	2006	[Quantification of expression of leukotriene B4 inducing tumor necrosis factor-alpha and interleukin-1beta at mRNA level in synovial membrane cells of rheumatoid arthritis by real-time quantitative PCR].	Leukotrienes	33-44	interleukin 1 beta	Homo sapiens	89-106
16973154-8	2006	Examination of the actin cytoskeleton on IL-1beta-activated endothelial cells showed that both 4 and 24 h of incubation with simvastatin produced a complete disappearance of F-actin, being completely restored by MVA and partially by GGPP and FPP after 24 h of coincubation.	Simvastatin	125-136	interleukin 1 beta	Homo sapiens	41-49
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	68-85
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	87-95
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	Mevalonic Acid	213-216	interleukin 1 beta	Homo sapiens	68-85
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	Mevalonic Acid	213-216	interleukin 1 beta	Homo sapiens	87-95
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	geranylgeranyl pyrophosphate	221-225	interleukin 1 beta	Homo sapiens	68-85
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	geranylgeranyl pyrophosphate	221-225	interleukin 1 beta	Homo sapiens	87-95
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	farnesyl pyrophosphate	246-249	interleukin 1 beta	Homo sapiens	68-85
16973154-6	2006	Simvastatin also significantly reduced the adhesion of monocytes to interleukin-1beta (IL-1beta)-activated endothelium to 80% after preincubation for 24 h. This effect was completely reversed by coincubation with MVA and GGPP, and partially with FPP.	farnesyl pyrophosphate	246-249	interleukin 1 beta	Homo sapiens	87-95
17068631-6	2006	LIT-treated synoviocytes with addition of MK-886 (5-LOX exciting protein FLAP inhibitor) (1-10 micromol/L) were inhibited to secrete LTB4 dose-dependently, following the markedly down-regulated expressions of TNF-alpha (15%-66%) and IL-1beta (41%-71%) at mRNA level .	MK-886	42-48	interleukin 1 beta	Homo sapiens	233-241
17068631-7	2006	Bestatin(100 mg/L) could also remarkably diminish LTB4-induced mRNA expressions of TNF-alpha(86%) and IL-1beta (79%).	ubenimex	0-8	interleukin 1 beta	Homo sapiens	102-110
17007741-9	2006	Further investigation showed that CGRP attenuated IL-1beta-aroused ROS formation, which is an early indication of pro-inflammatory factor signaling.	Reactive Oxygen Species	67-70	interleukin 1 beta	Homo sapiens	50-58
16887807-0	2006	Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors.	Tyrosine	65-73	interleukin 1 beta	Homo sapiens	0-18
16887807-11	2006	Altogether, our data show that gp120 releasing interleukin-1beta from glia increases tyrosine phosphorylation of NMDAR.	Tyrosine	85-93	interleukin 1 beta	Homo sapiens	47-64
17003335-3	2006	Fas, a death receptor regulated by IL-1beta, is involved in glucose-induced beta-cell apoptosis.	Glucose	60-67	interleukin 1 beta	Homo sapiens	35-43
17069099-6	2006	RESULTS: Nasopharyngeal concentrations of TNF-alpha, IL-1beta, and IL-10 were significantly and persistently lower in children treated with clarithromycin compared with placebo.	Clarithromycin	140-154	interleukin 1 beta	Homo sapiens	53-61
17069099-9	2006	CONCLUSION: Clarithromycin therapy reduces mucosal TNF-alpha, IL-1beta, and IL-10 concentrations in children with an acute exacerbation of recurrent wheezing.	Clarithromycin	12-26	interleukin 1 beta	Homo sapiens	62-70
16678783-5	2006	The stimulatory effect of EGF on IL-1beta-induced IL-8 production was completely abolished by the broad range tyrosine kinase inhibitor Herbimycin A, and considerably reduced by the receptor tyrosine kinase specific inhibitor PD 153035.	herbimycin	136-148	interleukin 1 beta	Homo sapiens	33-41
16678783-6	2006	Herbimycin A abolished IL-8 production induced by IL-1beta, whereas PD 153035 had no effect on the cytokine-induced IL-8 production.	herbimycin	0-12	interleukin 1 beta	Homo sapiens	50-58
16678783-7	2006	Furthermore, the p38 mitogen-activated protein (MAP) kinase inhibitor SB 203580 reduced IL-8 production induced by IL-1beta as well as by the combination of EGF and IL-1beta but had no effect on EGF-induced IL-8 production.	SB 203580	70-79	interleukin 1 beta	Homo sapiens	115-123
16678783-7	2006	Furthermore, the p38 mitogen-activated protein (MAP) kinase inhibitor SB 203580 reduced IL-8 production induced by IL-1beta as well as by the combination of EGF and IL-1beta but had no effect on EGF-induced IL-8 production.	SB 203580	70-79	interleukin 1 beta	Homo sapiens	165-173
16793131-9	2006	Finally, we observed that primary macrophages released higher amounts of TNF-alpha, IL-6 and IL-1beta after incubation with titanium particles than with rutile.	Titanium	124-132	interleukin 1 beta	Homo sapiens	93-101
16793192-7	2006	Promutoxin is also able to stimulate the release of IL-12, TNFalpha, IL-6 and IL-1beta from human monocytes, and induce IL-2, TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning.	promutoxin	0-10	interleukin 1 beta	Homo sapiens	78-86
16948668-7	2006	RESULTS: Interleukin-1beta and TNF-alpha stimulate PGE(2) production of human dental pulp cells (P &lt; 0.05).	Prostaglandins E	51-54	interleukin 1 beta	Homo sapiens	9-26
16948668-11	2006	CONCLUSIONS: Interleukin-1beta and TNF-alpha may stimulate PGE(2) production in dental pulp cells.	Dinoprostone	59-65	interleukin 1 beta	Homo sapiens	13-30
16954166-3	2006	We found that p-cresol significantly inhibited monocyte THP-1 cell line and PBMCs transmigration across IL-1beta-stimulated human umbilical vein endothelial cell (HUVEC) in a static two-compartment model.	4-cresol	14-22	interleukin 1 beta	Homo sapiens	104-112
16954166-6	2006	We found that p-cresol decreased mRNA expression of the chemokine fractalkine in IL-1beta-stimulated HUVEC, without modifying mRNA expression of MCP-1 and IL-8.	4-cresol	14-22	interleukin 1 beta	Homo sapiens	81-89
16954166-7	2006	In addition, p-cresol decreased IL-1beta-induced expression of membrane-bound and soluble forms of fractalkine and impaired the membrane expression of JAM-A.	cresol	15-21	interleukin 1 beta	Homo sapiens	32-40
17009243-11	2006	In OSM/IL-1beta- stimulated cocultures, cartilage sections demonstrated significant proteoglycan depletion that was paralleled by a significant increase in GAG release in supernatants.	Glycosaminoglycans	156-159	interleukin 1 beta	Homo sapiens	7-15
17450675-10	2006	Interestingly, overexpression of this enzyme completely counteracted the GAG depletion produced by the proinflammatory cytokine interleukin 1-beta.	Glycosaminoglycans	73-76	interleukin 1 beta	Homo sapiens	128-146
17291401-0	2006	Role of tumour necrosis factor alpha and interleukin 1 beta in promoter effect induced by mercury in human keratinocytes.	Mercury	90-97	interleukin 1 beta	Homo sapiens	41-59
17291401-10	2006	Although highly speculative, a review of the current literature would suggest that the GJIC inhibition induced by mercury might be the beginning of the promoter effect, but the role induced by cytokines on initiated cells to stimulate its proliferation remains to be determined We think that the reduction of TNF-alpha, and in part IL-1beta, induced by mercury might favour the cancer.	Mercury	114-121	interleukin 1 beta	Homo sapiens	332-340
16889628-11	2006	IL-1beta, albumin and AST were independently associated with cotinine level.	Cotinine	61-69	interleukin 1 beta	Homo sapiens	0-8
16955275-6	2006	Exposure to hyperthermia reduces IL-1beta-induced prostaglandin E2 release, suppresses activation of the adhesion molecules VCAM-1, ICAM-1, the cytokines TNFalpha, IL-1alpha, IL-1beta, IL-8 as well as COX-2 protein synthesis.	Dinoprostone	50-66	interleukin 1 beta	Homo sapiens	33-41
17003335-5	2006	Here, we show that IL-1beta at low concentrations may participate in the mitogenic actions of glucose through the Fas-FLIP pathway.	Glucose	94-101	interleukin 1 beta	Homo sapiens	19-27
16935997-7	2006	The presence of associations between the levels of PGE(2) enzyme mRNA expression and the effects of IL-1beta suggest that their expression is co-ordinated and that IL-1beta is the responsible factor.	Prostaglandins E	51-54	interleukin 1 beta	Homo sapiens	100-108
16807360-9	2006	HCl increased PAF and interleukin (IL)-1beta (but not IL-6, prostaglandin E(2), or H(2)O(2)) in mucosa, and only PAF was released into the supernatant, presumably to affect circular muscle.	Hydrochloric Acid	0-3	interleukin 1 beta	Homo sapiens	22-44
16807360-10	2006	In circular muscle, exogenous PAF induced sequential formation of IL-6, H(2)O(2), IL-1beta, and PAF.	Platelet Activating Factor	30-33	interleukin 1 beta	Homo sapiens	82-90
16935997-7	2006	The presence of associations between the levels of PGE(2) enzyme mRNA expression and the effects of IL-1beta suggest that their expression is co-ordinated and that IL-1beta is the responsible factor.	Prostaglandins E	51-54	interleukin 1 beta	Homo sapiens	164-172
16679036-8	2006	RESULTS: Compared to basal cells, stimulation with TNFalpha (10 ng/ml) and IL-1beta (5 ng/ml) for 48 h significantly decreased the activity of complex I (TNFalpha=35% and IL-1beta=35%) and the production of ATP (TNFalpha=18% and IL-1beta=19%).	Adenosine Triphosphate	207-210	interleukin 1 beta	Homo sapiens	75-83
17366783-6	2006	RESULTS: Conditioned medium with HPMC contained both TNF-alpha and IL-1beta.	hydroxypropylmethylcellulose-lactose matrix	33-37	interleukin 1 beta	Homo sapiens	67-75
16842752-7	2006	Moreover, we found that SM-7409 strongly inhibits the LPS-induced other pro-inflammatory cytokines, such as interleukin (IL)-1beta and IL-8 in PBMCs.	SM 7409	24-31	interleukin 1 beta	Homo sapiens	108-130
16597919-8	2006	Moreover, CGRP attenuated IL-1beta-induced reactive oxygen species (ROS) formation, the early event in proinflammatory factor signaling.	Reactive Oxygen Species	43-66	interleukin 1 beta	Homo sapiens	26-34
16597919-8	2006	Moreover, CGRP attenuated IL-1beta-induced reactive oxygen species (ROS) formation, the early event in proinflammatory factor signaling.	Reactive Oxygen Species	68-71	interleukin 1 beta	Homo sapiens	26-34
16597919-9	2006	We previously showed that the CGRP inhibitory effect was mediated by elevated intracellular cAMP and show here that analogs of cAMP, 8-bromoadenosine 3",5"-cyclic monophosphothioate and the Sp isomer of adenosine 3",5"-cyclic monophosphothioate, mimicked the CGRP suppressive effect on IL-1beta-induced ROS formation, NF-kappaB activation, and MCP-1 secretion.	8-bromoadenosine 3",5"-cyclic monophosphothioate	133-181	interleukin 1 beta	Homo sapiens	286-294
16597919-9	2006	We previously showed that the CGRP inhibitory effect was mediated by elevated intracellular cAMP and show here that analogs of cAMP, 8-bromoadenosine 3",5"-cyclic monophosphothioate and the Sp isomer of adenosine 3",5"-cyclic monophosphothioate, mimicked the CGRP suppressive effect on IL-1beta-induced ROS formation, NF-kappaB activation, and MCP-1 secretion.	TFF2 protein, human	190-192	interleukin 1 beta	Homo sapiens	286-294
16987005-3	2006	To determine the molecular source of ROS production in the human IL-1beta (hIL-1beta)-sensitive chondrocyte immortalized cell line C-20/A4, transfected cells were constructed that overexpress NAD(P)H oxidases.	nad(p)h	192-199	interleukin 1 beta	Homo sapiens	65-73
16987005-3	2006	To determine the molecular source of ROS production in the human IL-1beta (hIL-1beta)-sensitive chondrocyte immortalized cell line C-20/A4, transfected cells were constructed that overexpress NAD(P)H oxidases.	nad(p)h	192-199	interleukin 1 beta	Homo sapiens	75-84
16987005-7	2006	In C- 20/A4 cells that overexpress Nox4, hIL-1beta stimulated ROS production three times more than the normal production of C-20/A4 cells.	Reactive Oxygen Species	62-65	interleukin 1 beta	Homo sapiens	41-50
16987005-10	2006	These data suggest that under hIL-1beta stimulation, C-20/A4 chondrocytes produce MMP-1 through a Nox4-mediated, ROS-dependent pathway.	Reactive Oxygen Species	113-116	interleukin 1 beta	Homo sapiens	30-39
16782700-3	2006	IL-1beta increased endothelial cell endothelial nitric oxide (NO) synthase (eNOS) expression but did not enhance eNOS activity as evidenced by release of NO(x) into conditioned medium in response to acetylcholine or shear stress.	Nitric Oxide	48-60	interleukin 1 beta	Homo sapiens	0-8
16741924-0	2006	PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8.	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	30-38
16684958-7	2006	At nanomolar concentrations, ITF2357 reduces the secretion of IL-1beta following ATP activation of the P2X7 receptor.	givinostat hydrochloride	29-36	interleukin 1 beta	Homo sapiens	62-70
16684958-7	2006	At nanomolar concentrations, ITF2357 reduces the secretion of IL-1beta following ATP activation of the P2X7 receptor.	Adenosine Triphosphate	81-84	interleukin 1 beta	Homo sapiens	62-70
16741924-6	2006	As indicated by pharmacological studies, the full PGE2-dependent potentiation of IL-1beta induced PLA2 secretion is associated with a change of regulation exerted by the subtypes 3 G(i)-coupled PGE2 receptors toward adenylyl cyclase(s) activated by the subtype 4 G(s)-linked PGE2 receptor.	Dinoprostone	50-54	interleukin 1 beta	Homo sapiens	81-89
16952593-8	2006	Taurine level in group GT was higher than in group G. Arginine and citrulline levels in groups G and GT were lower than in group C. Taurine level in the small intestine was greater in group GT than in group G. Citrulline concentration was lower in group G than in groups GT and C. Endotoxin level in portal blood and cytokine (tumor necrosis factor alpha, interleukin-1beta, and interleukin-6) levels in blood tended to be lower for group GT than for group G, but no significant differences were noted.	Taurine	132-139	interleukin 1 beta	Homo sapiens	356-373
16952593-8	2006	Taurine level in group GT was higher than in group G. Arginine and citrulline levels in groups G and GT were lower than in group C. Taurine level in the small intestine was greater in group GT than in group G. Citrulline concentration was lower in group G than in groups GT and C. Endotoxin level in portal blood and cytokine (tumor necrosis factor alpha, interleukin-1beta, and interleukin-6) levels in blood tended to be lower for group GT than for group G, but no significant differences were noted.	Citrulline	210-220	interleukin 1 beta	Homo sapiens	356-373
16907851-12	2006	Finally, in vitro experiments suggested that the effect of ethanol on LDLR expression was indirectly mediated by both tumour necrosis factor-alpha and interleukin-1beta.	Ethanol	59-66	interleukin 1 beta	Homo sapiens	151-168
17072061-4	2006	In this study we evaluated the influence of N-acetylcysteine (NAC) (0.01 mM-30 mM) on the cytokine-induced (TNF-alpha/IL-1 beta) expression of the ICAM-1 adhesion molecule and on IL-8 release in endothelial (ECV-304) and bronchial epithelial (H292) cell lines.	Acetylcysteine	44-60	interleukin 1 beta	Homo sapiens	118-127
17072061-4	2006	In this study we evaluated the influence of N-acetylcysteine (NAC) (0.01 mM-30 mM) on the cytokine-induced (TNF-alpha/IL-1 beta) expression of the ICAM-1 adhesion molecule and on IL-8 release in endothelial (ECV-304) and bronchial epithelial (H292) cell lines.	Acetylcysteine	62-65	interleukin 1 beta	Homo sapiens	118-127
17072061-6	2006	NAC inhibited the TNF-alpha/IL-1 beta-stimulated ICAM-1 expression and IL-8 release from both cell lines in a concentration dependent manner.	Acetylcysteine	0-3	interleukin 1 beta	Homo sapiens	28-37
17072061-8	2006	We conclude that NAC is an effective inhibitor of TNF-alpha/IL-1 beta- stimulated ICAM-1 and IL-8 release in endothelial and epithelial cells.	Acetylcysteine	17-20	interleukin 1 beta	Homo sapiens	60-69
16448811-6	2006	However, pyocyanin upregulated the stimulatory effect of IL-1beta or PDBu on the release of IL-8 in a dose-dependent manner.	Pyocyanine	9-18	interleukin 1 beta	Homo sapiens	57-65
16887357-6	2006	Treatment with an IL-1beta receptor antagonist abrogates the effects of Fcmu on glial proliferation and prevents the upregulation of lipocalin in response to Fcmu, but does not prevent Fcmu-mediated upregulation of IL-1beta, suggesting that IL-1beta mediates at least some of the downstream effects of Fcmu in mixed glial cultures.	fcmu	72-76	interleukin 1 beta	Homo sapiens	18-26
16887357-6	2006	Treatment with an IL-1beta receptor antagonist abrogates the effects of Fcmu on glial proliferation and prevents the upregulation of lipocalin in response to Fcmu, but does not prevent Fcmu-mediated upregulation of IL-1beta, suggesting that IL-1beta mediates at least some of the downstream effects of Fcmu in mixed glial cultures.	fcmu	158-162	interleukin 1 beta	Homo sapiens	18-26
16887357-6	2006	Treatment with an IL-1beta receptor antagonist abrogates the effects of Fcmu on glial proliferation and prevents the upregulation of lipocalin in response to Fcmu, but does not prevent Fcmu-mediated upregulation of IL-1beta, suggesting that IL-1beta mediates at least some of the downstream effects of Fcmu in mixed glial cultures.	fcmu	158-162	interleukin 1 beta	Homo sapiens	18-26
16887357-6	2006	Treatment with an IL-1beta receptor antagonist abrogates the effects of Fcmu on glial proliferation and prevents the upregulation of lipocalin in response to Fcmu, but does not prevent Fcmu-mediated upregulation of IL-1beta, suggesting that IL-1beta mediates at least some of the downstream effects of Fcmu in mixed glial cultures.	fcmu	158-162	interleukin 1 beta	Homo sapiens	18-26
16887357-7	2006	We hypothesize that Fcmu-stimulated IL-1beta-induced upregulation of immediate early and late response genes in oligodendrocytes may promote CNS repair.	fcmu	20-24	interleukin 1 beta	Homo sapiens	36-44
16504556-3	2006	The induction of vascular cell adhesion molecule (VCAM), intercellular adhesion molecule (ICAM) and E-selectin by the cytokines TNFalpha and IL-1beta, and by bacterial lipopolysaccharide (LPS) was reduced by SNAP/Cys preincubation (30 min, 1mM) to less than 10% of controls.	snap	208-212	interleukin 1 beta	Homo sapiens	141-149
16504556-3	2006	The induction of vascular cell adhesion molecule (VCAM), intercellular adhesion molecule (ICAM) and E-selectin by the cytokines TNFalpha and IL-1beta, and by bacterial lipopolysaccharide (LPS) was reduced by SNAP/Cys preincubation (30 min, 1mM) to less than 10% of controls.	Cysteine	213-216	interleukin 1 beta	Homo sapiens	141-149
16532349-5	2006	SB203580, a specific p38 MAP kinase inhibitor, inhibited the production of IL-1beta-induced cytokines and MMPs, while the levels of the tissue inhibitor of metalloproteinase (TIMPs) were unchanged by treatment with SB203580.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	75-83
16532349-5	2006	SB203580, a specific p38 MAP kinase inhibitor, inhibited the production of IL-1beta-induced cytokines and MMPs, while the levels of the tissue inhibitor of metalloproteinase (TIMPs) were unchanged by treatment with SB203580.	SB 203580	215-223	interleukin 1 beta	Homo sapiens	75-83
16448811-7	2006	The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.	Pyocyanine	26-35	interleukin 1 beta	Homo sapiens	43-51
16448811-7	2006	The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.	Dexamethasone	116-129	interleukin 1 beta	Homo sapiens	43-51
16448811-7	2006	The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.	Budesonide	131-141	interleukin 1 beta	Homo sapiens	43-51
16448811-7	2006	The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.	Fluticasone	147-158	interleukin 1 beta	Homo sapiens	43-51
16448811-9	2006	The protein kinase C (PKC) inhibitor, Go6976, also significantly reduced the stimulatory effect of pyocyanin on IL-1beta, and PDBu increased IL-8 release.	Go 6976	38-44	interleukin 1 beta	Homo sapiens	112-120
16448811-9	2006	The protein kinase C (PKC) inhibitor, Go6976, also significantly reduced the stimulatory effect of pyocyanin on IL-1beta, and PDBu increased IL-8 release.	Pyocyanine	99-108	interleukin 1 beta	Homo sapiens	112-120
16448811-10	2006	In conclusion, this study shows that PKC signal pathway seems to be involved in the pyocyanin-mediated upregulation of the IL-1beta and PDBu-induced IL-8 release in BEAS-2B cells.	Pyocyanine	84-93	interleukin 1 beta	Homo sapiens	123-131
16869002-0	2006	Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts.	epigallocatechin gallate	106-132	interleukin 1 beta	Homo sapiens	14-31
16777324-3	2006	The present study examined the hypothesis that polymorphism of IL-1beta and IL-1Ra genes is involved in pain sensitivity and morphine consumption in the immediate postoperative period.	Morphine	125-133	interleukin 1 beta	Homo sapiens	63-71
16777324-5	2006	The genotype of IL-1Ra was determined using PCR amplification of the variable number of tandem repeats (VNTR) of 86 base pair (bp) in intron 2, while for IL-1beta the cytosine to thymine transition at codon -511 of the promoter was determined by PCR.	Cytosine	167-175	interleukin 1 beta	Homo sapiens	154-162
16777324-10	2006	Since IL-1Ra polymorphism is known to affect the levels of both IL-1Ra and IL-1, cytokines associated with modulation of pain sensitivity and morphine analgesia, it is suggested that IL-1Ra genetic polymorphism may contribute to the variation in postoperative morphine consumption.	Morphine	142-150	interleukin 1 beta	Homo sapiens	6-10
16777324-10	2006	Since IL-1Ra polymorphism is known to affect the levels of both IL-1Ra and IL-1, cytokines associated with modulation of pain sensitivity and morphine analgesia, it is suggested that IL-1Ra genetic polymorphism may contribute to the variation in postoperative morphine consumption.	Morphine	260-268	interleukin 1 beta	Homo sapiens	6-10
16476713-9	2006	However, synovial macrophage infiltration (CD68 antigen staining) and expression of proinflammatory mediators, such as interleukin 1beta and tumour necrosis factor alpha, were decreased only by CBX treatment.	Carboxin	194-197	interleukin 1 beta	Homo sapiens	119-169
16869002-8	2006	Treatment with EGCG at 10 microM or 20 microM significantly inhibited IL-1beta-induced ENA-78, RANTES, and GROalpha, but not MCP-1 production in a concentration-dependent manner.	epigallocatechin gallate	15-19	interleukin 1 beta	Homo sapiens	70-78
16869002-9	2006	EGCG at 50 microM caused a complete block of IL-1beta-induced production of RANTES, ENA-78, and GROalpha, and reduced production of MCP-1 by 48% (P &lt; 0.05).	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	45-53
16869002-10	2006	Zymography showed that EGCG blocked constitutive, IL-1beta-induced, and chemokine-mediated MMP-2 activity.	epigallocatechin gallate	23-27	interleukin 1 beta	Homo sapiens	50-58
16869002-11	2006	Evaluation of signaling events revealed that EGCG preferentially blocked the phosphorylation of PKCdelta and inhibited the activation and nuclear translocation of NF-kappaB in IL-1beta-treated RA synovial fibroblasts.	epigallocatechin gallate	45-49	interleukin 1 beta	Homo sapiens	176-184
16326073-3	2006	Treatment of these cells with IL-1beta increased the levels of COX-2 mRNA and protein and hence the production of PGE2.	Dinoprostone	114-118	interleukin 1 beta	Homo sapiens	30-38
16326073-8	2006	Interestingly, inhibition of p38 MAPK by SB203580 severely decreased induction of COX-2 expression by IL-1beta.	SB 203580	41-49	interleukin 1 beta	Homo sapiens	102-110
16807371-0	2006	Activation of sPLA2-IIA and PGE2 production by high mobility group protein B1 in vascular smooth muscle cells sensitized by IL-1beta.	Dinoprostone	28-32	interleukin 1 beta	Homo sapiens	124-132
16911361-7	2006	RESULTS: Real-time PCR revealed that poly I : C significantly increased the expression of mRNAs for chemokines IP-10, RANTES, LARC, MIP-1alpha, IL-8, GRO-alpha and ENA-78 and cytokines IL-1beta, GM-CSF, IL-6 and the cell adhesion molecule ICAM-1 in both cell types.	Poly I	37-43	interleukin 1 beta	Homo sapiens	185-193
16675961-8	2006	Concomitantly, we demonstrated that EFs stimulation induced NF-kappaB nuclear translocation and DNA binding on IL-1beta promoter region whereas inhibition of NF-kappaB with the specific chemical inhibitor SN-50 or by overexpression of IkappaB, the endogenous inhibitor of NF-kappaB pathway, totally abolished EFs-mediated IL-1beta mRNA overexpression.	SN-50	205-210	interleukin 1 beta	Homo sapiens	111-119
16820944-11	2006	Moreover, elevated hepatic levels of TNF-alpha and IL-1beta post-CLP were decreased by curcumin pre-treatment.	Curcumin	87-95	interleukin 1 beta	Homo sapiens	51-59
16861295-4	2006	In this study, we hypothesized that clodronate prevents the mechanical stress-induced production of prostaglandin E(2) (PGE(2)), interleukin-1beta (IL-1beta), and nitric oxide (NO) in human PDL cells.	Clodronic Acid	36-46	interleukin 1 beta	Homo sapiens	129-146
16861295-4	2006	In this study, we hypothesized that clodronate prevents the mechanical stress-induced production of prostaglandin E(2) (PGE(2)), interleukin-1beta (IL-1beta), and nitric oxide (NO) in human PDL cells.	Clodronic Acid	36-46	interleukin 1 beta	Homo sapiens	148-156
16809572-7	2006	Proinflammatory cytokines (interleukin-1beta and interferon-gamma) upregulate Fn14 expression in hASMCs.	hasmcs	97-103	interleukin 1 beta	Homo sapiens	27-44
16769766-7	2006	Effects on endothelial CAM of other proinflammatory cytokines, such as interleukin-1beta and interferon-gamma, were also inhibited significantly by tripterine.	celastrol	148-158	interleukin 1 beta	Homo sapiens	71-88
16797033-7	2006	Berberrubine dose-dependently inhibited IL-8 and MCP-1 protein levels in the media and mRNA expression of the cells stimulated with IL-1beta or TNF-alpha.	berberrubine	0-12	interleukin 1 beta	Homo sapiens	132-140
16797033-9	2006	Fluorescein was dense (215+/-42 or 170+/-24 arbitrary units, respectively) 30 min after stimulation with IL-1beta or TNF-alpha and was decreased to 62+/-18 or 47+/-16 arbitrary units, respectively, by berberrubine.	Fluorescein	0-11	interleukin 1 beta	Homo sapiens	105-113
16797033-10	2006	Berberrubine dose-dependently inhibited IL-8 and MCP-1 expression and protein secretion induced by IL-1beta or TNF-alpha.	berberrubine	0-12	interleukin 1 beta	Homo sapiens	99-107
16698013-4	2006	The production of IL-6, IL-8, and prostaglandin (PG)E2 was significantly increased by IL-1beta plus A beta (1-42) in a time-dependent manner (P &lt; 0.05).	Dinoprostone	34-54	interleukin 1 beta	Homo sapiens	86-94
16698013-5	2006	JST significantly inhibited the IL-1beta plus A beta (1-42)-induced IL-6, IL-8, and PGE2 production at 24 h (P &lt; 0.05).	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	32-40
16566946-0	2006	Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma.	sinomenine	10-20	interleukin 1 beta	Homo sapiens	47-56
16687389-5	2006	LPS priming also potentiated IL-1beta mRNA induction by DON in human whole-blood cultures, suggesting the relevance of the murine findings.	deoxynivalenol	56-59	interleukin 1 beta	Homo sapiens	29-37
16614347-6	2006	LPS-induced release of 10 cytokines was less suppressed by dexamethasone (10(-6) M) in patients with severe asthma compared with patients with nonsevere asthma, with statistical significance achieved for IL-1beta (p &lt; 0.03), IL-8 (p &lt; 0.03), and MIP-1alpha (p &lt; 0.003), and borderline significance for IL-6 (p = 0.054).	Dexamethasone	59-72	interleukin 1 beta	Homo sapiens	204-212
16566946-6	2006	Sinomenine could significantly inhibit proliferation of IL-1 beta-activated Hs701.T cells and suppress expression of 17 genes including IL-6, PlGF, Daxx, and HSP27.	sinomenine	0-10	interleukin 1 beta	Homo sapiens	56-65
16566946-2	2006	This study aimed to investigate the effect of sinomenine on gene expression of human synovial sarcoma cells (Hs701.T) activated by IL-1 beta.	sinomenine	46-56	interleukin 1 beta	Homo sapiens	131-140
16617094-10	2006	AS-602868 but not PD-98059 or SP-600125 inhibited p65 DNA-binding induced by IL-1beta and TNF-alpha.	AS602868	0-9	interleukin 1 beta	Homo sapiens	77-85
16617094-3	2006	ASMC were cultured from human airways, grown to confluence, and exposed to cytokines IL-1beta and TNF-alpha after growth arrest.	asmc	0-4	interleukin 1 beta	Homo sapiens	85-93
16617094-11	2006	By chromatin immunoprecipitation assay, IL-1beta and TNF-alpha enhanced p65 binding to the GRO-alpha promoter, which was inhibited by AS-602868.	AS602868	134-143	interleukin 1 beta	Homo sapiens	40-48
16617094-7	2006	Supernatants from IL-1beta-stimulated ASMC were chemotactic for neutrophils; this effect was inhibited by anti-GRO-alpha blocking antibody.	asmc	38-42	interleukin 1 beta	Homo sapiens	18-26
16617094-12	2006	IL-1beta- and TNF-alpha-stimulated expression of GRO-alpha from ASMC is regulated by independent pathways involving NF-kappaB activation and ERK and JNK pathways.	asmc	64-68	interleukin 1 beta	Homo sapiens	0-8
16829183-3	2006	Both TNF-alpha and IL-1beta induced HUVEC platelet-activating factor (PAF) production and PAF was required for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists (BN-52021 or CV-6209) and a PAF synthesis inhibitor (sanguinarine).	sanguinarine	260-272	interleukin 1 beta	Homo sapiens	19-27
16802349-9	2006	RESULTS: IL-1beta-induced JNK phosphorylation was dependent on MKK-7 but not on MKK-4; however, anisomycin-activated JNK required both kinases.	Anisomycin	96-106	interleukin 1 beta	Homo sapiens	9-17
16819191-0	2006	Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	126-134
16702992-7	2006	Both chol-but SLN and sodium butyrate displayed antiadhesive effects on FMLP- and IL-1beta-stimulated cells in a concentration-response curve (10(-8)-10(-5) M), but chol-but SLN were in all cases more active.	chol	5-9	interleukin 1 beta	Homo sapiens	82-90
16819191-5	2006	Curcumin significantly inhibited the binding of Stx and the production of Gb3 synthase (GalT6) mRNA in HT29 IECs stimulated with TNF-alpha and IL-1beta.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	143-151
16702992-7	2006	Both chol-but SLN and sodium butyrate displayed antiadhesive effects on FMLP- and IL-1beta-stimulated cells in a concentration-response curve (10(-8)-10(-5) M), but chol-but SLN were in all cases more active.	Butyric Acid	22-37	interleukin 1 beta	Homo sapiens	82-90
16956425-8	2006	Vitamin D stimulated the expression of cox-2 mRNA which was further enhanced by TNF-alpha/IL-1beta.	Vitamin D	0-9	interleukin 1 beta	Homo sapiens	90-98
16633892-14	2006	When added in the presence of lipopolysaccharide, CGP42112 reduced the lipopolysaccharide-stimulated secretion of the pro-inflammatory cytokines TNF-alpha, IL-1, IL-1 beta, and IL-6, and increased protein kinase A.	CGP 42112A	50-58	interleukin 1 beta	Homo sapiens	156-160
16633892-14	2006	When added in the presence of lipopolysaccharide, CGP42112 reduced the lipopolysaccharide-stimulated secretion of the pro-inflammatory cytokines TNF-alpha, IL-1, IL-1 beta, and IL-6, and increased protein kinase A.	CGP 42112A	50-58	interleukin 1 beta	Homo sapiens	162-171
16815316-10	2006	CONCLUSIONS: IL1B -511 polymorphism, but not IL1RN, TNFA, or IL10 polymorphism, is one of the determinants of triple therapy for clarithromycin-sensitive strains of H pylori in CYP2C19 homozygous EMs.	Clarithromycin	129-143	interleukin 1 beta	Homo sapiens	13-17
16474845-6	2006	The increased IL-1beta secretion was accompanied by an elevated formation of nitric oxide (NO) and a NO-dependent inhibition of the etoposide-induced caspase-3/-7/-8/-9 activity.	Nitric Oxide	77-89	interleukin 1 beta	Homo sapiens	14-22
17077666-7	2006	In contrast, Dex treatment inhibited the IL-1beta-induced production of GM-CSF, IL-6, IL-8, MCP-3, and RANTES, but not MCP-1.	Dexamethasone	13-16	interleukin 1 beta	Homo sapiens	41-49
16804397-8	2006	RESULTS: The assay was highly sensitive and specific for detection of profound defects in muramyl dipeptide sensing caused by double NOD2 mutations (IL-8 P = 0.0002; IL-1beta P = 0.0002).	Dipeptides	98-107	interleukin 1 beta	Homo sapiens	166-174
16805677-14	2006	These findings support the hypothesis that ASU could exert a preventive action on the deleterious effects exerted by IL-1beta in periodontal diseases.	asu	43-46	interleukin 1 beta	Homo sapiens	117-125
16492401-15	2006	Inhibition of PGE2 synthesis by indomethacin increased the cell death induced by IL-1beta/Act-D (59%).	Dinoprostone	14-18	interleukin 1 beta	Homo sapiens	81-89
16492401-15	2006	Inhibition of PGE2 synthesis by indomethacin increased the cell death induced by IL-1beta/Act-D (59%).	Indomethacin	32-44	interleukin 1 beta	Homo sapiens	81-89
16449361-0	2006	Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kappaB and p38.	Hyaluronic Acid	69-79	interleukin 1 beta	Homo sapiens	83-100
16449361-2	2006	We have previously shown that hyaluronan (HA) inhibits IL-1beta actions in RSF via CD44, the principal HA receptor.	Hyaluronic Acid	30-40	interleukin 1 beta	Homo sapiens	55-63
16449361-2	2006	We have previously shown that hyaluronan (HA) inhibits IL-1beta actions in RSF via CD44, the principal HA receptor.	Hyaluronic Acid	42-44	interleukin 1 beta	Homo sapiens	55-63
16449361-10	2006	RESULTS: Production of MMP-1 and MMP-3 by RSF was stimulated by IL-1beta.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	42-45	interleukin 1 beta	Homo sapiens	64-72
16714221-0	2006	Fraxetin inhibits the induction of anti-Fas IgM, tumor necrosis factor-alpha and interleukin-1beta-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63.	fraxetin	0-8	interleukin 1 beta	Homo sapiens	81-98
16714221-6	2006	Treatment of MG-63 cells with fraxetin not only inhibited anti-Fas IgM-induced apoptosis, but also blocked the synergetic effect of anti-Fas IgM with TNF-alpha or IL-1beta on cell death.	fraxetin	30-38	interleukin 1 beta	Homo sapiens	163-171
16714221-7	2006	The apoptotic inhibition of fraxetin is associated with inhibition of TNF-alpha and IL-1beta-mediated Fas expression and enhancement of FLIP expression, resulting in a decrease of caspase-8 and caspase-3 activation.	fraxetin	28-36	interleukin 1 beta	Homo sapiens	84-92
16641320-10	2006	ROFA also inhibited the increase of IL-1beta-induced human beta-defensin-2, a homologue of TAP, in A549 cells.	rofa	0-4	interleukin 1 beta	Homo sapiens	36-44
16580800-5	2006	Also, in the group treated only with IL-1beta (11.9+/-0.3 microg), the amount of released GAG increased significantly compared to the control (7.9+/-0.1 microg) and the SFEA-treated group (7.8+/-0.4 microg).	Glycosaminoglycans	90-93	interleukin 1 beta	Homo sapiens	37-45
16580800-5	2006	Also, in the group treated only with IL-1beta (11.9+/-0.3 microg), the amount of released GAG increased significantly compared to the control (7.9+/-0.1 microg) and the SFEA-treated group (7.8+/-0.4 microg).	sfea	169-173	interleukin 1 beta	Homo sapiens	37-45
16481008-5	2006	Cell proliferation and inhibition of interleukin 1beta (IL-1beta) induced prostaglandin (PG) production were examined.	Prostaglandins	74-92	interleukin 1 beta	Homo sapiens	37-54
16474845-6	2006	The increased IL-1beta secretion was accompanied by an elevated formation of nitric oxide (NO) and a NO-dependent inhibition of the etoposide-induced caspase-3/-7/-8/-9 activity.	Etoposide	132-141	interleukin 1 beta	Homo sapiens	14-22
16481008-5	2006	Cell proliferation and inhibition of interleukin 1beta (IL-1beta) induced prostaglandin (PG) production were examined.	Prostaglandins	74-92	interleukin 1 beta	Homo sapiens	56-64
16474845-8	2006	Conversely, IL-1beta or the NO-donor SNAP decreased caspase activation and apoptosis in etoposide-treated PT45-P1 cells.	Etoposide	88-97	interleukin 1 beta	Homo sapiens	12-20
16800873-5	2006	RESULTS: Formation of triglyceride-loaded foam cells resulted in a four-fold increase in basal IL-1beta secretion, whereas cholesterol loading lacked significant effect on IL-1beta secretion.	Triglycerides	22-34	interleukin 1 beta	Homo sapiens	95-103
16499933-7	2006	Moreover, we found that normal human PBMC pulsed with PCBs, p,p"-DDE and their combination showed a significant down-regulation of NK cell cytotoxic activity and IL-1beta and IL-12 production.	Polychlorinated Biphenyls	54-58	interleukin 1 beta	Homo sapiens	162-170
16499933-7	2006	Moreover, we found that normal human PBMC pulsed with PCBs, p,p"-DDE and their combination showed a significant down-regulation of NK cell cytotoxic activity and IL-1beta and IL-12 production.	Dichlorodiphenyl Dichloroethylene	60-68	interleukin 1 beta	Homo sapiens	162-170
16800873-9	2006	The exception was IL-1beta, where triglyceride, but not cholesterol, lipid loading resulted in a stimulation of basal secretion of the cytokine.	Triglycerides	34-46	interleukin 1 beta	Homo sapiens	18-26
16364386-5	2006	Significantly increased IL-6 and IL-1beta intracellular protein and mRNA expression was also observed in PBMC treated with DON (500 ng/ml) which were also partially p38-dependent.	deoxynivalenol	123-126	interleukin 1 beta	Homo sapiens	33-41
16497336-6	2006	PMF supplementation also reduced TG contents in the liver and heart and was able to regulate adipocytokines by significantly suppressing TNF-alpha, INF-gamma, IL-1beta and IL-6 expression and increasing adiponectin in IR hamsters.	Phenylmethylsulfonyl Fluoride	0-3	interleukin 1 beta	Homo sapiens	159-167
16514055-6	2006	ATP-induced MMP-9 release was inhibited by the P2X(7) receptor antagonists periodate oxidized ATP and KN-62, or by calcium chelators, as well as by a loss-of-function polymorphism in the P2X(7) receptor, but not by brefeldin A, monensin, or cycloheximide, or by anti-tumor necrosis factor-alpha (TNF-alpha) or anti-interleukin-1beta (IL-1beta) monoclonal antibodies.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	334-342
16620783-8	2006	IL-1beta-pretreated NT2-N induced the chemotaxis of PBMC, which was significantly reduced by anti-IL-8, but not by anti-MIP-1beta neutralizing antibody.	nt2-n	20-25	interleukin 1 beta	Homo sapiens	0-8
16551633-6	2006	Pretreatment with the proteasome inhibitor MG132 blocks IL-1beta-mediated reductions in nuclear RXRalpha levels while increasing accumulation in the cytoplasm.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	43-48	interleukin 1 beta	Homo sapiens	56-64
16551633-7	2006	Mutational studies identify one residue, serine 260, a JNK phosphoacceptor site whose phosphorylation status had an unknown role in RXRalpha function, as critical for IL-1beta-mediated nuclear export of transfected human RXRalpha-green fluorescent fusion constructs.	Serine	41-47	interleukin 1 beta	Homo sapiens	167-175
16380201-2	2006	The expression of the argininosuccinate synthetase gene (ASS), the limiting enzyme of arginine synthesis, was previously shown to be rapidly induced by a short-term (4 h) exposure to IL-1beta in Caco-2 cells [Biochimie, 2005, 403-409].	Arginine	86-94	interleukin 1 beta	Homo sapiens	183-191
16357062-11	2006	IL-1beta-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous PGE(2) restored this inhibitory effect, suggesting the activation of an IL-1beta-COX-2-PGE(2) pathway that culminates in the release of HRG from fibroblasts.	Celecoxib	70-79	interleukin 1 beta	Homo sapiens	0-8
16357062-11	2006	IL-1beta-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous PGE(2) restored this inhibitory effect, suggesting the activation of an IL-1beta-COX-2-PGE(2) pathway that culminates in the release of HRG from fibroblasts.	Celecoxib	70-79	interleukin 1 beta	Homo sapiens	167-175
16357062-11	2006	IL-1beta-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous PGE(2) restored this inhibitory effect, suggesting the activation of an IL-1beta-COX-2-PGE(2) pathway that culminates in the release of HRG from fibroblasts.	Prostaglandins E	95-98	interleukin 1 beta	Homo sapiens	0-8
16357062-11	2006	IL-1beta-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous PGE(2) restored this inhibitory effect, suggesting the activation of an IL-1beta-COX-2-PGE(2) pathway that culminates in the release of HRG from fibroblasts.	Prostaglandins E	95-98	interleukin 1 beta	Homo sapiens	167-175
16357062-11	2006	IL-1beta-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous PGE(2) restored this inhibitory effect, suggesting the activation of an IL-1beta-COX-2-PGE(2) pathway that culminates in the release of HRG from fibroblasts.	Prostaglandins E	182-185	interleukin 1 beta	Homo sapiens	0-8
16357062-11	2006	IL-1beta-stimulated HRG expression and release were also inhibited by celecoxib, and exogenous PGE(2) restored this inhibitory effect, suggesting the activation of an IL-1beta-COX-2-PGE(2) pathway that culminates in the release of HRG from fibroblasts.	Prostaglandins E	182-185	interleukin 1 beta	Homo sapiens	167-175
16269423-3	2006	RESULTS: The most significant intracellular decrease in cytokines was observed by ICC in SM treated with the combination of Lef-M (1, 10, 30 micromol/l) and MTX (50 ng/ml) versus untreated SM (TNFalpha 29%, 37%, 49%, IL1beta 56%, 43%, 50%, and IL6 59%, 62%, 71%, respectively).	Methotrexate	157-160	interleukin 1 beta	Homo sapiens	217-224
16269423-4	2006	Furthermore, a significant decrease was confirmed concerning cytokine levels evaluated by ELISA in the medium of SM treated with the combination Lef-M+MTX (TNFalpha 40%, 41%, 44%; IL1beta 10%, 20%, 60%; IL6 37%, 41%, 49%, respectively).	Methotrexate	151-154	interleukin 1 beta	Homo sapiens	180-187
16380201-4	2006	Concerning the mechanism involved, we demonstrate that the inhibiting effect is linked to the production of nitric oxide (NO) induced by IL-1beta.	Nitric Oxide	108-120	interleukin 1 beta	Homo sapiens	137-145
16380201-5	2006	Indeed, the inhibiting effect of IL-1beta was totally blocked in the presence of l-NMMA, an inhibitor of the inducible nitric oxide synthase, or by culturing the cells in an arginine-deprived medium.	omega-N-Methylarginine	81-87	interleukin 1 beta	Homo sapiens	33-41
16736518-6	2006	RESULTS: ICs containing anti-CII from arthritis patients induced the production of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-8.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	29-32	interleukin 1 beta	Homo sapiens	123-140
16380201-5	2006	Indeed, the inhibiting effect of IL-1beta was totally blocked in the presence of l-NMMA, an inhibitor of the inducible nitric oxide synthase, or by culturing the cells in an arginine-deprived medium.	Arginine	174-182	interleukin 1 beta	Homo sapiens	33-41
16736518-6	2006	RESULTS: ICs containing anti-CII from arthritis patients induced the production of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-8.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	29-32	interleukin 1 beta	Homo sapiens	142-150
16736518-9	2006	Anti-CII-containing IC-induced cytokine production was almost totally abolished (&gt;99%) after monocyte depletion, and receptor blocking studies showed significant decreases in the production of TNFalpha, IL-1beta, and IL-8 after blocking Fc gammaRIIa, but not after blocking Fc gammaRIII.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	5-8	interleukin 1 beta	Homo sapiens	206-214
16723203-0	2006	The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1.	pyrrolidine dithiocarbamic acid	24-51	interleukin 1 beta	Homo sapiens	59-67
16544161-1	2006	Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms.	Nitric Oxide	79-91	interleukin 1 beta	Homo sapiens	23-41
16544161-1	2006	Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms.	Nitric Oxide	79-91	interleukin 1 beta	Homo sapiens	43-52
16544161-1	2006	Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms.	Dinoprostone	102-118	interleukin 1 beta	Homo sapiens	23-41
16544161-1	2006	Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms.	Dinoprostone	102-118	interleukin 1 beta	Homo sapiens	43-52
16544161-1	2006	Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms.	Dinoprostone	120-124	interleukin 1 beta	Homo sapiens	23-41
16544161-1	2006	Mechanical loading and interleukin-1 beta (IL-1 beta) influence the release of nitric oxide (*NO) and prostaglandin E2 (PGE2) from articular chondrocytes via distinct signalling mechanisms.	Dinoprostone	120-124	interleukin 1 beta	Homo sapiens	43-52
16776680-12	2006	Moreover, alginic acid significantly inhibited the production of PMA+A23187-induced inflammatory cytokines, IL-1beta and TNF-alpha, but not that of IL-6 or IL-8.	Alginic Acid	10-22	interleukin 1 beta	Homo sapiens	108-116
16776680-12	2006	Moreover, alginic acid significantly inhibited the production of PMA+A23187-induced inflammatory cytokines, IL-1beta and TNF-alpha, but not that of IL-6 or IL-8.	Calcimycin	69-75	interleukin 1 beta	Homo sapiens	108-116
16723203-6	2006	Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely.	pyrrolidine dithiocarbamic acid	29-33	interleukin 1 beta	Homo sapiens	42-50
16723203-6	2006	Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Homo sapiens	42-50
16636195-7	2006	A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside (AICAR), dose-dependently inhibited TNF-alpha- and interleukin-1beta-induced NF-kappaB reporter gene expression.	5-amino-4-imidazole carboxamide riboside	37-77	interleukin 1 beta	Homo sapiens	129-146
16691186-3	2006	High glucose concentrations induce IL-1beta production in human beta-cells, Fas expression and concomitant apoptosis owing to a constitutive expression of FasL.	Glucose	5-12	interleukin 1 beta	Homo sapiens	35-43
16636195-7	2006	A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside (AICAR), dose-dependently inhibited TNF-alpha- and interleukin-1beta-induced NF-kappaB reporter gene expression.	acadesine	79-84	interleukin 1 beta	Homo sapiens	129-146
16453302-8	2006	Here we show that IL-1beta stimulation of chondrocytes induced phosphorylation of C/EBP-beta on threonine 235, and that the ERK pathway inhibitor PD98059 reduced this phosphorylation.	Threonine	96-105	interleukin 1 beta	Homo sapiens	18-26
16644475-2	2006	We show here that a commonly used generic antidepressant bupropion, in wide use worldwide to treat depression in humans for a decade now, profoundly lowers levels of TNF, interferon-gamma, and interleukin-1 beta in vivo, in a mouse lipopolysaccharide (LPS) induced inflammation model.	Bupropion	57-66	interleukin 1 beta	Homo sapiens	193-211
16751012-1	2006	BACKGROUND: Levels of COX-2 and downstream products, such as prostaglandin (PG) E2, are increased in inflammatory settings after stimulation by IL-1beta, LPS, and other innate factors.	Dinoprostone	61-82	interleukin 1 beta	Homo sapiens	144-152
16453302-8	2006	Here we show that IL-1beta stimulation of chondrocytes induced phosphorylation of C/EBP-beta on threonine 235, and that the ERK pathway inhibitor PD98059 reduced this phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	146-153	interleukin 1 beta	Homo sapiens	18-26
16525037-10	2006	ML120B also blocked IL-1beta-induced prostaglandin E2 production.	Dinoprostone	37-53	interleukin 1 beta	Homo sapiens	20-28
16453302-9	2006	We further show that PD98059 reduces IL-1beta-induced MMP-1 mRNA expression in chondrocytes.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	21-28	interleukin 1 beta	Homo sapiens	37-45
16626814-5	2006	We found that IL-1beta, but not IL-10 or tumour necrosis factor (TNF)-alpha, down-regulated the surface expression and Ser831 phosphorylation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluR1.	SCHEMBL8160703	173-205	interleukin 1 beta	Homo sapiens	14-22
16626814-8	2006	The inhibition of NMDA receptor activity or depletion of extracellular calcium blocked IL-1beta effects on GluR1 phosphorylation and surface expression.	Calcium	71-78	interleukin 1 beta	Homo sapiens	87-95
16626814-9	2006	NMDA-mediated calcium influx was also regulated by IL-1beta.	N-Methylaspartate	0-4	interleukin 1 beta	Homo sapiens	51-59
16626814-9	2006	NMDA-mediated calcium influx was also regulated by IL-1beta.	Calcium	14-21	interleukin 1 beta	Homo sapiens	51-59
16626814-10	2006	These findings suggest that IL-1beta selectively regulates AMPA receptor phosphorylation and surface expression through extracellular calcium and an unknown mechanism involving NMDA receptor activity.	Calcium	134-141	interleukin 1 beta	Homo sapiens	28-36
16731790-4	2006	Our results show for the first time that testosterone-replacement therapy is associated with a reduction or complete abrogation of spontaneous ex vivo production of IL-1beta, IL-6 and TNFalpha by APCs.	Testosterone	41-53	interleukin 1 beta	Homo sapiens	165-173
16709823-4	2006	High doses of estradiol enhance LPS-induced IL-1beta expression in an estrogen receptor-dependent manner.	Estradiol	14-23	interleukin 1 beta	Homo sapiens	44-52
16739069-10	2006	The IL-1beta-mediated increase of IL-8 secretion was significantly inhibited by GTE in a dose-dependent manner.	epigallocatechin gallate	80-83	interleukin 1 beta	Homo sapiens	4-12
16159661-4	2006	Moreover we found that: (i) this cell line releases prostaglandin E2 and the output is enhanced by interleukin-1beta; (ii) the prostanoid consistently inhibits serum- or epidermal growth factor-induced cell proliferation and also migration.	Prostaglandins	127-137	interleukin 1 beta	Homo sapiens	99-116
16183115-10	2006	We conclude that mPGES-1 is not involved in the inducible COX-2 mediated pathway for PGE2 biosynthesis at the transcriptional level, however, the treatment with IL-1beta results in a higher degree of co-ordination of the mPGES-1 and COX-2 protein immunolocalization, eliciting PGE2 synthesis.	Dinoprostone	277-281	interleukin 1 beta	Homo sapiens	161-169
16764700-5	2006	Pentoxyfilline resulted in decreased expression of mRNA of liver IL-1beta, TNF-alpha and IFN-gamma: 144.2 versus 83.5 molecules of IL-1beta (P &lt; 0.05), TNF-alpha 194.3 versus 17.6 molecules (P = 0.03) and IFN-gamma 26.1 versus 0.5 molecules (P = 0.04).	Pentoxifylline	0-14	interleukin 1 beta	Homo sapiens	65-73
16418198-0	2006	Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes.	Chloroquine	0-11	interleukin 1 beta	Homo sapiens	46-54
16418198-2	2006	The anti-rheumatic drug chloroquine has been shown to inhibit TNF-alpha, IL-1 and IL-6 production from mononuclear phagocytes.	Chloroquine	24-35	interleukin 1 beta	Homo sapiens	73-77
16418198-9	2006	In contrast, chloroquine-induced inhibition of IL-1beta and IL-6 release was accompanied by a decrease in their steady-state mRNA levels.	Chloroquine	13-24	interleukin 1 beta	Homo sapiens	47-55
16418198-10	2006	The transcription rates of the IL-1beta and IL-6 genes were not changed by chloroquine, whereas the stability of IL-1beta and IL-6 mRNA was decreased by chloroquine.	Chloroquine	153-164	interleukin 1 beta	Homo sapiens	113-121
16418198-11	2006	Weak-base amines such as methylamine and ammonium chloride had no effect on the production of TNF-alpha, whereas they partially blocked the production of IL-1beta and IL-6.	weak-base amines	0-16	interleukin 1 beta	Homo sapiens	154-162
16418198-12	2006	CONCLUSIONS: Our results indicate that chloroquine-mediated inhibition of TNF-alpha, IL-1beta and IL-6 synthesis occurs through different modes in lipopolysaccharide-stimulated human monocytes/macrophages: it blocks the conversion of cell-associated TNF-alpha precursor to mature soluble protein, whereas it reduces the levels of IL-1beta and IL-6 mRNA, at least in part, by decreasing their stability and by a pH-dependent mechanism.	Chloroquine	39-50	interleukin 1 beta	Homo sapiens	85-93
16764700-5	2006	Pentoxyfilline resulted in decreased expression of mRNA of liver IL-1beta, TNF-alpha and IFN-gamma: 144.2 versus 83.5 molecules of IL-1beta (P &lt; 0.05), TNF-alpha 194.3 versus 17.6 molecules (P = 0.03) and IFN-gamma 26.1 versus 0.5 molecules (P = 0.04).	Pentoxifylline	0-14	interleukin 1 beta	Homo sapiens	131-139
16418198-12	2006	CONCLUSIONS: Our results indicate that chloroquine-mediated inhibition of TNF-alpha, IL-1beta and IL-6 synthesis occurs through different modes in lipopolysaccharide-stimulated human monocytes/macrophages: it blocks the conversion of cell-associated TNF-alpha precursor to mature soluble protein, whereas it reduces the levels of IL-1beta and IL-6 mRNA, at least in part, by decreasing their stability and by a pH-dependent mechanism.	Chloroquine	39-50	interleukin 1 beta	Homo sapiens	330-338
16567807-5	2006	Confocal images in both cell types revealed that IL-1beta increases recruitment of GABA(A)Rs to the cell surface.	gamma-Aminobutyric Acid	83-87	interleukin 1 beta	Homo sapiens	49-57
16567019-3	2006	Within cartilage and synovium, pro-inflammatory cytokines, particularly IL-1b and TNF-a, auto-catalytically stimulate their own production and induce chondrocytes to produce additional catabolic mediators, including proteases, chemokines, nitric oxide, and prostaglandins.	Nitric Oxide	239-251	interleukin 1 beta	Homo sapiens	72-77
16567807-6	2006	Moreover, brief applications of IL-1beta to voltage-clamped oocytes yielded a delayed potentiation of the GABA-elicited chloride currents (I(GABA)); this effect was suppressed by IL-1ra, the natural IL-1 receptor (IL-1RI) antagonist.	gamma-Aminobutyric Acid	106-110	interleukin 1 beta	Homo sapiens	32-40
16567807-6	2006	Moreover, brief applications of IL-1beta to voltage-clamped oocytes yielded a delayed potentiation of the GABA-elicited chloride currents (I(GABA)); this effect was suppressed by IL-1ra, the natural IL-1 receptor (IL-1RI) antagonist.	Chlorides	120-128	interleukin 1 beta	Homo sapiens	32-40
16567807-6	2006	Moreover, brief applications of IL-1beta to voltage-clamped oocytes yielded a delayed potentiation of the GABA-elicited chloride currents (I(GABA)); this effect was suppressed by IL-1ra, the natural IL-1 receptor (IL-1RI) antagonist.	gamma-Aminobutyric Acid	141-145	interleukin 1 beta	Homo sapiens	32-40
16567807-7	2006	Western blot analysis combined with I(GABA) recording and confocal images of GABA(A) Rs in oocytes showed that IL-1beta stimulates the IL-1RI-dependent phosphatidylinositol 3-kinase activation and the consequent facilitation of phospho-Akt-mediated insertion of GABA(A)Rs into the cell surface.	gamma-Aminobutyric Acid	38-42	interleukin 1 beta	Homo sapiens	111-119
16567807-7	2006	Western blot analysis combined with I(GABA) recording and confocal images of GABA(A) Rs in oocytes showed that IL-1beta stimulates the IL-1RI-dependent phosphatidylinositol 3-kinase activation and the consequent facilitation of phospho-Akt-mediated insertion of GABA(A)Rs into the cell surface.	gamma-Aminobutyric Acid	77-81	interleukin 1 beta	Homo sapiens	111-119
16567807-7	2006	Western blot analysis combined with I(GABA) recording and confocal images of GABA(A) Rs in oocytes showed that IL-1beta stimulates the IL-1RI-dependent phosphatidylinositol 3-kinase activation and the consequent facilitation of phospho-Akt-mediated insertion of GABA(A)Rs into the cell surface.	gamma-Aminobutyric Acid	77-81	interleukin 1 beta	Homo sapiens	111-119
16567019-3	2006	Within cartilage and synovium, pro-inflammatory cytokines, particularly IL-1b and TNF-a, auto-catalytically stimulate their own production and induce chondrocytes to produce additional catabolic mediators, including proteases, chemokines, nitric oxide, and prostaglandins.	Prostaglandins	257-271	interleukin 1 beta	Homo sapiens	72-77
16547349-11	2006	A1, A2, anandamide, the CB2 antagonist SR144528 (Ki &lt;10 nM), and also the non-CB2-binding alkylamide undeca-2E-ene,8,10-diynoic acid isobutylamide all significantly inhibited lipopolysaccharide-induced tumor necrosis factor alpha, IL-1beta, and IL-12p70 expression (5-500 nM) in a CB2-independent manner.	8,10-diynoic acid isobutylamide	118-149	interleukin 1 beta	Homo sapiens	234-242
16361361-7	2006	ATP, adenosine, and UTP significantly stimulated MMP-2 release in the presence of IL-1beta (300 nM ATP: 181 +/- 22%, P = 0.003; 30 microm adenosine: 244 +/- 150%, P = 0.001; and 200 microm UTP: 153 +/- 40%, P = 0.015; vs. 100% constitutive).	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	82-90
16555295-7	2006	DNA fragmentation ELISA and MTT assay showed that prolonged IL-1beta activation of astrocytes induced significant astrocyte death.	monooxyethylene trimethylolpropane tristearate	28-31	interleukin 1 beta	Homo sapiens	60-68
16361361-7	2006	ATP, adenosine, and UTP significantly stimulated MMP-2 release in the presence of IL-1beta (300 nM ATP: 181 +/- 22%, P = 0.003; 30 microm adenosine: 244 +/- 150%, P = 0.001; and 200 microm UTP: 153 +/- 40%, P = 0.015; vs. 100% constitutive).	Adenosine	5-14	interleukin 1 beta	Homo sapiens	82-90
16361361-7	2006	ATP, adenosine, and UTP significantly stimulated MMP-2 release in the presence of IL-1beta (300 nM ATP: 181 +/- 22%, P = 0.003; 30 microm adenosine: 244 +/- 150%, P = 0.001; and 200 microm UTP: 153 +/- 40%, P = 0.015; vs. 100% constitutive).	Uridine Triphosphate	20-23	interleukin 1 beta	Homo sapiens	82-90
16361361-7	2006	ATP, adenosine, and UTP significantly stimulated MMP-2 release in the presence of IL-1beta (300 nM ATP: 181 +/- 22%, P = 0.003; 30 microm adenosine: 244 +/- 150%, P = 0.001; and 200 microm UTP: 153 +/- 40%, P = 0.015; vs. 100% constitutive).	Adenosine Triphosphate	99-102	interleukin 1 beta	Homo sapiens	82-90
16361361-7	2006	ATP, adenosine, and UTP significantly stimulated MMP-2 release in the presence of IL-1beta (300 nM ATP: 181 +/- 22%, P = 0.003; 30 microm adenosine: 244 +/- 150%, P = 0.001; and 200 microm UTP: 153 +/- 40%, P = 0.015; vs. 100% constitutive).	Adenosine	138-147	interleukin 1 beta	Homo sapiens	82-90
16361361-7	2006	ATP, adenosine, and UTP significantly stimulated MMP-2 release in the presence of IL-1beta (300 nM ATP: 181 +/- 22%, P = 0.003; 30 microm adenosine: 244 +/- 150%, P = 0.001; and 200 microm UTP: 153 +/- 40%, P = 0.015; vs. 100% constitutive).	Uridine Triphosphate	189-192	interleukin 1 beta	Homo sapiens	82-90
16543490-3	2006	METHODS AND RESULTS: IL-1beta enhanced transformation of vascular smooth muscle cells into foam cells by increasing uptake of unmodified LDL via LDL receptors and by enhancing cholesterol esterification as demonstrated by Oil Red O staining and direct assay of intracellular cholesterol concentrations.	Cholesterol	176-187	interleukin 1 beta	Homo sapiens	21-29
16424382-5	2006	We investigated modulation of rhinovirus- and IL-1beta-induced bronchial epithelial cell chemokine production by salmeterol and fluticasone propionate, used at therapeutic concentrations, alone and in combination.	Salmeterol Xinafoate	113-123	interleukin 1 beta	Homo sapiens	46-54
16424382-5	2006	We investigated modulation of rhinovirus- and IL-1beta-induced bronchial epithelial cell chemokine production by salmeterol and fluticasone propionate, used at therapeutic concentrations, alone and in combination.	Fluticasone	128-150	interleukin 1 beta	Homo sapiens	46-54
16424382-6	2006	After 1 h pretreatment, combined treatment significantly inhibited rhinovirus 16, 1B, and IL-1beta-induced CCL5 and CXCL8 protein and mRNA production in BEAS-2B cells compared with fluticasone alone.	Fluticasone	181-192	interleukin 1 beta	Homo sapiens	90-98
16497991-7	2006	BPS attenuated the IL-1beta-mediated decrease in eNOS promoter activity and the expression of eNOS gene through PKA pathway.	beraprost	0-3	interleukin 1 beta	Homo sapiens	19-27
16497991-2	2006	We examined the effects of Beraprost sodium (BPS), a stable analogue of prostacyclin, on the eNOS gene expression in the presence of inflammatory cytokine interleukin (IL)-1beta in cultured endothelial cells.	beraprost	27-43	interleukin 1 beta	Homo sapiens	155-177
16497991-2	2006	We examined the effects of Beraprost sodium (BPS), a stable analogue of prostacyclin, on the eNOS gene expression in the presence of inflammatory cytokine interleukin (IL)-1beta in cultured endothelial cells.	beraprost	45-48	interleukin 1 beta	Homo sapiens	155-177
16543490-3	2006	METHODS AND RESULTS: IL-1beta enhanced transformation of vascular smooth muscle cells into foam cells by increasing uptake of unmodified LDL via LDL receptors and by enhancing cholesterol esterification as demonstrated by Oil Red O staining and direct assay of intracellular cholesterol concentrations.	oil red O	222-231	interleukin 1 beta	Homo sapiens	21-29
16543490-3	2006	METHODS AND RESULTS: IL-1beta enhanced transformation of vascular smooth muscle cells into foam cells by increasing uptake of unmodified LDL via LDL receptors and by enhancing cholesterol esterification as demonstrated by Oil Red O staining and direct assay of intracellular cholesterol concentrations.	Cholesterol	275-286	interleukin 1 beta	Homo sapiens	21-29
16543490-7	2006	CONCLUSIONS: These observations demonstrate that IL-1beta disrupts cholesterol-mediated LDL receptor feedback regulation, permitting intracellular accumulation of unmodified LDL and causing foam cell formation.	Cholesterol	67-78	interleukin 1 beta	Homo sapiens	49-57
16520738-3	2006	Buddlejasaponin IV (2.5-10 microM) reduced lipopolysaccaride (LPS (1 microg ml(-1)))-induced levels of iNOS and COX-2 at the protein levels, and iNOS, COX-2, TNF-alpha, interleukin (IL)-1beta and IL-6 mRNA expression in RAW 264.7 macrophages in a concentration-dependent manner, as determined by Western blotting and RT-PCR, respectively.	lipopolysaccaride	43-60	interleukin 1 beta	Homo sapiens	169-191
16520738-4	2006	Buddlejasaponin IV inhibited the LPS-induced activation of nuclear factor-kappaB (NF-kappaB), a transcription factor necessary for proinflammatory mediators, iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 expression.	buddlejasaponin	0-15	interleukin 1 beta	Homo sapiens	182-190
16487663-7	2006	IL-1beta-induced PGE2 production and effects of PGE2 on the synthesis of procollagen by culture-derived fibroblasts were determined by using enzyme-linked immunosorbant assay (ELISA) kits.	Dinoprostone	17-21	interleukin 1 beta	Homo sapiens	0-8
16487663-11	2006	IL-1beta (1 ng/ml and 10 ng/ml) stimulated statistically significant production (p&lt;0.01) of PGE2 by both normal and keloid-derived fibroblasts.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	0-8
16670534-7	2006	Cultured EGCs were treated with interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, and lipopolysaccharides.	gallocatechol	9-13	interleukin 1 beta	Homo sapiens	32-49
16084692-5	2006	Pretreatment of IB3-1 cells with the ER Ca(2+) pump inhibitor thapsigargin inhibited the IL-1beta-induced [Ca(2+)](i) response.	Thapsigargin	62-74	interleukin 1 beta	Homo sapiens	89-97
16084692-6	2006	Treatment with either the calcium chelator BAPTA or an inhibitor of I(kappa)Balpha phosphorylation (digitoxin) led to a drastic [Ca(2+)](i) decrease accompanied by an inhibition of NF-(kappa)B activation of IL-1beta-stimulated IB3-1 cells in comparison to untreated cells.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	43-48	interleukin 1 beta	Homo sapiens	207-215
16084692-6	2006	Treatment with either the calcium chelator BAPTA or an inhibitor of I(kappa)Balpha phosphorylation (digitoxin) led to a drastic [Ca(2+)](i) decrease accompanied by an inhibition of NF-(kappa)B activation of IL-1beta-stimulated IB3-1 cells in comparison to untreated cells.	Digitoxin	100-109	interleukin 1 beta	Homo sapiens	207-215
16670522-10	2006	The addition of chloroquine abolished the inhibitory effects of ISS-ODNs on colonic TNF-alpha and IL-1beta generation.	Chloroquine	16-27	interleukin 1 beta	Homo sapiens	98-106
16670534-7	2006	Cultured EGCs were treated with interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, and lipopolysaccharides.	gallocatechol	9-13	interleukin 1 beta	Homo sapiens	51-59
16504308-4	2006	Inhibition of HIF-1alpha degradation by proteasome inhibitor, MG-132, potentiated hypoxia-induced IL-1beta release from human astrocytes, and this response was blocked in the presence of CdCl2.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	62-68	interleukin 1 beta	Homo sapiens	98-106
16621994-9	2006	We showed that simvastatin stimulates the secretion of IL-18 and IL-1beta in monocytes.	Simvastatin	15-26	interleukin 1 beta	Homo sapiens	65-73
16621994-10	2006	Active caspase-1, which is required for the processing and secretion of IL-18 and IL-1beta, was activated in simvastatin-treated monocytes.	Simvastatin	109-120	interleukin 1 beta	Homo sapiens	82-90
16556676-6	2006	By contrast, with the existing known human endometrial cell lines Ishikawa and KLE, HIESC and HIEEC increase their production of PGF2alpha and PGE2 and cyclooxygenase (COX)-2 protein expression in response to IL-1beta.	Dinoprost	129-138	interleukin 1 beta	Homo sapiens	209-217
16556676-8	2006	The selective COX-2 inhibitor NS-398 completely inhibits the increased production of PGs induced by IL-1beta in both cell types, whereas dexamethasone (DEX) exerts a stronger inhibition in HIESC than in HIEEC.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	30-36	interleukin 1 beta	Homo sapiens	100-108
16556676-8	2006	The selective COX-2 inhibitor NS-398 completely inhibits the increased production of PGs induced by IL-1beta in both cell types, whereas dexamethasone (DEX) exerts a stronger inhibition in HIESC than in HIEEC.	Prostaglandins	85-88	interleukin 1 beta	Homo sapiens	100-108
15993984-4	2006	This analysis confirms the upregulation caused by both sAbeta(1-42) and fAbeta(1-42) of pro-inflammatory molecules such as TNF-alpha, interleukin-1beta and macrophage inflammatory protein-1alpha.	sabeta	55-61	interleukin 1 beta	Homo sapiens	134-151
15993984-4	2006	This analysis confirms the upregulation caused by both sAbeta(1-42) and fAbeta(1-42) of pro-inflammatory molecules such as TNF-alpha, interleukin-1beta and macrophage inflammatory protein-1alpha.	fabeta	72-78	interleukin 1 beta	Homo sapiens	134-151
16421162-16	2006	CONCLUSIONS: Diltiazem suppressed collagen synthesis of human PMCs and inhibited IL-1beta-induced TGF-beta1 production on human PMCs.	Diltiazem	13-22	interleukin 1 beta	Homo sapiens	81-89
16469798-0	2006	Enhancement of cortisol-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by interleukin 1beta in cultured human chorionic trophoblast cells.	Hydrocortisone	15-23	interleukin 1 beta	Homo sapiens	89-106
16469798-10	2006	We conclude that cortisol up-regulates 11beta-HSD1 expression through induction of promoter activity, and the effect was enhanced by IL-1beta, suggesting that more biologically active glucocorticoids could be generated in the fetal membranes in the presence of infection, which may consequently feed forward in up-regulation of prostaglandin synthesis.	Prostaglandins	328-341	interleukin 1 beta	Homo sapiens	133-141
16529823-3	2006	In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH.	Ascorbic Acid	35-48	interleukin 1 beta	Homo sapiens	76-93
16529823-3	2006	In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH.	Ascorbic Acid	35-48	interleukin 1 beta	Homo sapiens	95-103
16529823-3	2006	In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH.	Dinoprostone	114-118	interleukin 1 beta	Homo sapiens	76-93
16529823-3	2006	In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH.	Dinoprostone	114-118	interleukin 1 beta	Homo sapiens	95-103
16529823-6	2006	The inhibition of IL-1beta-mediated PGE2 synthesis by ascorbic acid was not due to the inhibition of the expression of COX-2 or microsomal prostaglandin E synthase (mPGES-1).	Dinoprostone	36-40	interleukin 1 beta	Homo sapiens	18-26
16529823-6	2006	The inhibition of IL-1beta-mediated PGE2 synthesis by ascorbic acid was not due to the inhibition of the expression of COX-2 or microsomal prostaglandin E synthase (mPGES-1).	Ascorbic Acid	54-67	interleukin 1 beta	Homo sapiens	18-26
16529823-7	2006	Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress.	Ascorbic Acid	8-21	interleukin 1 beta	Homo sapiens	92-100
16529823-7	2006	Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress.	8-epi-prostaglandin F2alpha	124-151	interleukin 1 beta	Homo sapiens	92-100
16529823-7	2006	Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress.	Dinoprost	159-168	interleukin 1 beta	Homo sapiens	92-100
16529823-7	2006	Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress.	Free Radicals	195-207	interleukin 1 beta	Homo sapiens	92-100
16529823-7	2006	Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress.	Ascorbic Acid	250-263	interleukin 1 beta	Homo sapiens	92-100
16529823-7	2006	Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress.	Dinoprostone	282-286	interleukin 1 beta	Homo sapiens	92-100
16421162-0	2006	Diltiazem suppresses collagen synthesis and IL-1beta-induced TGF-beta1 production on human peritoneal mesothelial cells.	Diltiazem	0-9	interleukin 1 beta	Homo sapiens	44-52
16421162-4	2006	The objectives of this study were to examine the effects of diltiazem on collagen- and IL-1beta-induced TGF-beta1 production on human PMCs and the signalling pathway of diltiazem in this induction.	Diltiazem	60-69	interleukin 1 beta	Homo sapiens	87-95
16421162-4	2006	The objectives of this study were to examine the effects of diltiazem on collagen- and IL-1beta-induced TGF-beta1 production on human PMCs and the signalling pathway of diltiazem in this induction.	Diltiazem	169-178	interleukin 1 beta	Homo sapiens	87-95
16421162-12	2006	Diltiazem (0.2 mM) suppressed IL-1beta- (5 ng/ml) induced TGF-beta1 production on human PMCs at both the protein and mRNA levels.	Diltiazem	0-9	interleukin 1 beta	Homo sapiens	30-38
16421162-13	2006	Diltiazem (0.2 mM) also inhibited IL-1beta- (5 ng/ml) induced collagen I and III mRNA expression.	Diltiazem	0-9	interleukin 1 beta	Homo sapiens	34-42
16421162-15	2006	The IL-1beta-treated human PMCs increased phospho-JNK (stress-activated c-Jun N-terminal kinase) and phospho-p38 MAPK expression, while diltiazem could suppress this phenomenon.	Diltiazem	136-145	interleukin 1 beta	Homo sapiens	4-12
16504308-4	2006	Inhibition of HIF-1alpha degradation by proteasome inhibitor, MG-132, potentiated hypoxia-induced IL-1beta release from human astrocytes, and this response was blocked in the presence of CdCl2.	Cadmium Chloride	187-192	interleukin 1 beta	Homo sapiens	98-106
16670622-9	2006	RESULTS: Preincubation of the mesothelial monolayer with IL-1beta or TNF-alpha resulted in enhanced tumor cell adhesion of the MiaPaCa-2 and BxPC-3 cells.	mesothelial	30-41	interleukin 1 beta	Homo sapiens	57-65
16529714-8	2006	SbS also inhibited IL-8 production, prevented IkappaB alpha degradation, and reduced both NF-kappaB-DNA binding and NF-kappaB reporter gene up-regulation in IL-1beta or LPS-stimulated THP-1 cells.	sbs	0-3	interleukin 1 beta	Homo sapiens	157-165
16510232-7	2006	In the case of mAb-activation, secretion of interleukin (IL)-1 beta, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma was greatly inhibited at low Cd doses compared to production of IL-4 and IL-10.	Cadmium	160-162	interleukin 1 beta	Homo sapiens	44-67
16603065-10	2006	However, in the presence of IL-1beta both RNI 249 and vincaria protected IGF-1 production in an additive manner (P &lt; 0.01) with the combination restoring chondrocyte IGF-1 production to normal levels.	rni	42-45	interleukin 1 beta	Homo sapiens	28-36
16572457-6	2006	RESULTS: CloF counteracted IL-1beta-induced 35S-proteoglycan degradation, gelatinolytic activity, and MMP-1, -3, and -13 mRNA expression.	Clofibrate	9-13	interleukin 1 beta	Homo sapiens	27-35
16572457-6	2006	RESULTS: CloF counteracted IL-1beta-induced 35S-proteoglycan degradation, gelatinolytic activity, and MMP-1, -3, and -13 mRNA expression.	Sulfur-35	44-47	interleukin 1 beta	Homo sapiens	27-35
16572457-7	2006	CloF also maximized IL-1beta-induced endogenous production of soluble IL-1Ra (sIL-1Ra).	Clofibrate	0-4	interleukin 1 beta	Homo sapiens	20-28
16257277-0	2006	-511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone.	Diphosphonates	63-78	interleukin 1 beta	Homo sapiens	9-13
16257277-8	2006	However, the -511 CC genotype of the IL1B gene was associated with a higher percentage of resistance to BSP (49% vs. 20%; P = 0.00 for all BSP, 60% vs. 39%, P = 0.17 for etidronate, 50% vs. 37% P = 0.53 for clodronate, 48 vs. 34% P = 0.05 for tiludronate and 50% vs. 4% P = 0.01 for risedronate).	Etidronic Acid	170-180	interleukin 1 beta	Homo sapiens	37-41
16257277-8	2006	However, the -511 CC genotype of the IL1B gene was associated with a higher percentage of resistance to BSP (49% vs. 20%; P = 0.00 for all BSP, 60% vs. 39%, P = 0.17 for etidronate, 50% vs. 37% P = 0.53 for clodronate, 48 vs. 34% P = 0.05 for tiludronate and 50% vs. 4% P = 0.01 for risedronate).	Clodronic Acid	207-217	interleukin 1 beta	Homo sapiens	37-41
16257277-8	2006	However, the -511 CC genotype of the IL1B gene was associated with a higher percentage of resistance to BSP (49% vs. 20%; P = 0.00 for all BSP, 60% vs. 39%, P = 0.17 for etidronate, 50% vs. 37% P = 0.53 for clodronate, 48 vs. 34% P = 0.05 for tiludronate and 50% vs. 4% P = 0.01 for risedronate).	tiludronic acid	243-254	interleukin 1 beta	Homo sapiens	37-41
16257277-8	2006	However, the -511 CC genotype of the IL1B gene was associated with a higher percentage of resistance to BSP (49% vs. 20%; P = 0.00 for all BSP, 60% vs. 39%, P = 0.17 for etidronate, 50% vs. 37% P = 0.53 for clodronate, 48 vs. 34% P = 0.05 for tiludronate and 50% vs. 4% P = 0.01 for risedronate).	Risedronic Acid	283-294	interleukin 1 beta	Homo sapiens	37-41
16257277-9	2006	CONCLUSIONS: Our results suggest that the -511 CC genotype of the IL1B gene could be related to resistance to bisphosphonates in patients with PDB.	Diphosphonates	110-125	interleukin 1 beta	Homo sapiens	66-70
16600024-8	2006	Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 beta	Homo sapiens	73-81
16600024-8	2006	Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone.	Prednisolone	185-197	interleukin 1 beta	Homo sapiens	73-81
16603065-13	2006	IL-1beta - induced degradation of cartilage matrix was quantified as glycosaminoglycan release.	Glycosaminoglycans	69-86	interleukin 1 beta	Homo sapiens	0-8
16723255-4	2006	TNFalpha and IL-1beta increased the production of H2O2 to similar levels in cells, suggesting that increased production of reactive oxygen species might not be the premier factor involved.	Hydrogen Peroxide	50-54	interleukin 1 beta	Homo sapiens	13-21
16723255-4	2006	TNFalpha and IL-1beta increased the production of H2O2 to similar levels in cells, suggesting that increased production of reactive oxygen species might not be the premier factor involved.	Reactive Oxygen Species	123-146	interleukin 1 beta	Homo sapiens	13-21
16423868-11	2006	Together, the data indicate an autocrine-amplifying loop involving IL-1beta-regulated Sertoli function mediated by COX-2-induced PGE(2) and PGF(2alpha) production.	Prostaglandins E	129-132	interleukin 1 beta	Homo sapiens	67-75
16423868-11	2006	Together, the data indicate an autocrine-amplifying loop involving IL-1beta-regulated Sertoli function mediated by COX-2-induced PGE(2) and PGF(2alpha) production.	Prostaglandins F	140-143	interleukin 1 beta	Homo sapiens	67-75
16423868-1	2006	In Sertoli epithelial cells, the IL-1beta induces prostaglandins (PG) PGE(2), PGF(2alpha) and PGI(2) (7-, 11-, and 2-fold, respectively), but not PGD(2), production.	Prostaglandins E	50-73	interleukin 1 beta	Homo sapiens	33-41
16423868-1	2006	In Sertoli epithelial cells, the IL-1beta induces prostaglandins (PG) PGE(2), PGF(2alpha) and PGI(2) (7-, 11-, and 2-fold, respectively), but not PGD(2), production.	Prostaglandins F	78-81	interleukin 1 beta	Homo sapiens	33-41
16456536-6	2006	Pretreatment of the ic-IL-1ra-transfected cells with antisense oligonucleotide directed against the mRNA of icIL-1ra restored MMP-1 expression induced by stimulation with IL-1beta.	Oligonucleotides	63-78	interleukin 1 beta	Homo sapiens	171-179
16423868-1	2006	In Sertoli epithelial cells, the IL-1beta induces prostaglandins (PG) PGE(2), PGF(2alpha) and PGI(2) (7-, 11-, and 2-fold, respectively), but not PGD(2), production.	Prostaglandins I	94-97	interleukin 1 beta	Homo sapiens	33-41
16423868-1	2006	In Sertoli epithelial cells, the IL-1beta induces prostaglandins (PG) PGE(2), PGF(2alpha) and PGI(2) (7-, 11-, and 2-fold, respectively), but not PGD(2), production.	Prostaglandins D	146-149	interleukin 1 beta	Homo sapiens	33-41
16423868-2	2006	Cyclohexamide pretreatment inhibiting protein synthesis prevents IL-1beta increases in PG levels, indicating that induction requires de novo protein synthesis.	4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione	0-13	interleukin 1 beta	Homo sapiens	65-73
16423868-2	2006	Cyclohexamide pretreatment inhibiting protein synthesis prevents IL-1beta increases in PG levels, indicating that induction requires de novo protein synthesis.	Prostaglandins	87-89	interleukin 1 beta	Homo sapiens	65-73
16423868-3	2006	IL-1beta-regulated PGE(2) and PGF(2alpha) production and cytokine expression require activation of cyclooxygenase-2 (COX-2) and c-Jun NH(2)-terminal kinase, as shown using specific enzyme inhibition.	Prostaglandins E	19-22	interleukin 1 beta	Homo sapiens	0-8
16423868-3	2006	IL-1beta-regulated PGE(2) and PGF(2alpha) production and cytokine expression require activation of cyclooxygenase-2 (COX-2) and c-Jun NH(2)-terminal kinase, as shown using specific enzyme inhibition.	Prostaglandins F	30-33	interleukin 1 beta	Homo sapiens	0-8
16423868-5	2006	PGE(2) and PGF(2alpha) reverse COX-2-mediated inhibition of IL-1beta induction of cytokine expression and PG production.	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	60-68
16423868-5	2006	PGE(2) and PGF(2alpha) reverse COX-2-mediated inhibition of IL-1beta induction of cytokine expression and PG production.	Prostaglandins F	11-14	interleukin 1 beta	Homo sapiens	60-68
16423868-5	2006	PGE(2) and PGF(2alpha) reverse COX-2-mediated inhibition of IL-1beta induction of cytokine expression and PG production.	Prostaglandins	0-2	interleukin 1 beta	Homo sapiens	60-68
16423868-10	2006	Consistent with EP(2)-cAMP signaling, protein kinase A inhibition blocks both IL-1beta- and PGE(2)-induced cytokines.	Cyclic AMP	22-26	interleukin 1 beta	Homo sapiens	78-86
16202406-11	2006	SB202190, PD98059 and doxycycline markedly suppressed the levels of p-JNK-1/p-JNK-2 and/or p-ERK1/p-ERK2, as well as IL-1beta, TNF-alpha and IL-8 mRNAs and proteins stimulated by hyperosmolar media.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	0-8	interleukin 1 beta	Homo sapiens	117-125
16202406-11	2006	SB202190, PD98059 and doxycycline markedly suppressed the levels of p-JNK-1/p-JNK-2 and/or p-ERK1/p-ERK2, as well as IL-1beta, TNF-alpha and IL-8 mRNAs and proteins stimulated by hyperosmolar media.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	10-17	interleukin 1 beta	Homo sapiens	117-125
16202406-11	2006	SB202190, PD98059 and doxycycline markedly suppressed the levels of p-JNK-1/p-JNK-2 and/or p-ERK1/p-ERK2, as well as IL-1beta, TNF-alpha and IL-8 mRNAs and proteins stimulated by hyperosmolar media.	Doxycycline	22-33	interleukin 1 beta	Homo sapiens	117-125
16250012-9	2006	IL-1beta-induced tyrosine phosphorylation of SHP-2 on residue Y542 promoted focal adhesion maturation.	Tyrosine	17-25	interleukin 1 beta	Homo sapiens	0-8
16250012-11	2006	We conclude that IL-1beta mediated maturation of focal adhesions is dependent on tyrosine phosphorylation of SHP-2 at Y542, leading to recruitment of Gab1, a process that may influence the downstream activation of ERK.	Tyrosine	81-89	interleukin 1 beta	Homo sapiens	17-25
16352705-5	2006	In primary human peripheral blood mononuclear cells, dose-dependent inhibition of LPS-induced tumor necrosis factor (TNF)-alpha, IL-6, MCP-1, and IL-1beta by tipifarnib was observed with no evidence of cytotoxicity.	tipifarnib	158-168	interleukin 1 beta	Homo sapiens	146-154
16539678-3	2006	We herein report that sulfated polymannuroguluronate (SPMG), a novel anti-acquired immunodeficiency syndrome drug candidate now in a phase II clinical trial, significantly reversed Tat-induced release of pro-inflammatory cytokines [tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta) and IL-6] and dose dependently decreased the accumulation of reactive oxygen species and nitric oxide in THP-1 cells.	polymannuroguluronate	31-52	interleukin 1 beta	Homo sapiens	268-290
16539678-3	2006	We herein report that sulfated polymannuroguluronate (SPMG), a novel anti-acquired immunodeficiency syndrome drug candidate now in a phase II clinical trial, significantly reversed Tat-induced release of pro-inflammatory cytokines [tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta) and IL-6] and dose dependently decreased the accumulation of reactive oxygen species and nitric oxide in THP-1 cells.	sulfated polymannuroguluronate	54-58	interleukin 1 beta	Homo sapiens	268-290
16380374-5	2006	Surprisingly, this brief exposure to FC-AMs triggered a modest proinflammatory response in the phagocytes: tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta were induced, whereas the levels of transforming growth factor-beta and IL-10 were not increased.	fc-ams	37-43	interleukin 1 beta	Homo sapiens	151-173
16553947-0	2006	Beta-(1--&gt;3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio.	beta-(1--&gt;3)-d-glucan	0-24	interleukin 1 beta	Homo sapiens	131-139
16307851-8	2006	PGE(2) is synergistic with IL-1beta and TNF-alpha in the induction of functional and phenotypic maturation of DC and induce IL12 p40 production.	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	27-35
16531984-1	2006	Reactive oxygen species formation and release of pro-inflammatory/pro-atherogenic cytokines, that is, interleukin 1-beta and tumor necrosis factor-alpha, need the activation of the arachidonic acid cascade via the enzyme 5-lipoxygenase (5-Lox).	Reactive Oxygen Species	0-23	interleukin 1 beta	Homo sapiens	102-152
16531984-1	2006	Reactive oxygen species formation and release of pro-inflammatory/pro-atherogenic cytokines, that is, interleukin 1-beta and tumor necrosis factor-alpha, need the activation of the arachidonic acid cascade via the enzyme 5-lipoxygenase (5-Lox).	Arachidonic Acid	181-197	interleukin 1 beta	Homo sapiens	102-152
16553947-8	2006	Further, glucan phosphate modulated the TSST-1-induced inflammatory response via reduction of IL-1beta and IL-6.	glucan phosphate	9-25	interleukin 1 beta	Homo sapiens	94-102
16553947-9	2006	As a consequence, glucan phosphate shifted the TSST-1-induced IL-1beta/IL-1RA ratio towards an anti-inflammatory phenotype.	glucan phosphate	18-34	interleukin 1 beta	Homo sapiens	62-70
16553947-10	2006	Subsequently, glucan phosphate decreased the TSST-1-induced, IL-1-dependent production of IL-2.	glucan phosphate	14-30	interleukin 1 beta	Homo sapiens	61-65
16551868-3	2006	Using human leukemia cell lines and patient samples, we show that CDDO-Me potently inhibits both constitutive and inducible NF-kappaB activated by tumor necrosis factor (TNF), interleukin (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, and cigarette smoke.	bardoxolone methyl	66-73	interleukin 1 beta	Homo sapiens	176-198
16517732-3	2006	Our data show that in X-linked agammaglobulinemia PBMCs, stimulation with TLR4 (LPS) or TLR2 (N-palmitoyl-S-[2, 3-bis(palmitoyloxy)-(2R)-propyl]-(R)-cysteine) ligands produces significantly less TNF and IL-1beta than in normal controls.	n-palmitoyl-s-[2, 3-bis(palmitoyloxy)-(2r)-propyl]-(r)-cysteine	94-157	interleukin 1 beta	Homo sapiens	203-211
16380374-7	2006	TNF-alpha and IL-1beta induction required one or more proteins on the FC-AM surface and was dependent on signaling through extracellular signal-regulated kinase-1/2 mitogen-activated protein kinase and nuclear factor-kappaB in the phagocytes.	fc-am	70-75	interleukin 1 beta	Homo sapiens	14-22
16377638-5	2006	Because several of these genes are regulated by NF-kappaB, we postulated that SAHA mediates its effects by modulating NF-kappaB and found that SAHA suppressed NF-kappaB activation induced by TNF, IL-1beta, okadaic acid, doxorubicin, lipopolysaccharide, H(2)O(2), phorbol myristate acetate, and cigarette smoke; the suppression was not cell type-specific because both inducible and constitutive NF-kappaB activation was inhibited.	Vorinostat	78-82	interleukin 1 beta	Homo sapiens	196-204
16564702-12	2006	However, in endothelial cells stimulated with ATP, the released fraction was effective in attenuating IL-1beta activation of the IL-8 reporter.	Adenosine Triphosphate	46-49	interleukin 1 beta	Homo sapiens	102-110
16564702-13	2006	These results suggest that icIL-1ra1 does not act at an intracellular level to alter IL-1 mediated signalling, and is effective in inhibiting IL-1 responses only when released in an ATP-dependent and cell type specific manner.	Adenosine Triphosphate	182-185	interleukin 1 beta	Homo sapiens	29-33
16377638-5	2006	Because several of these genes are regulated by NF-kappaB, we postulated that SAHA mediates its effects by modulating NF-kappaB and found that SAHA suppressed NF-kappaB activation induced by TNF, IL-1beta, okadaic acid, doxorubicin, lipopolysaccharide, H(2)O(2), phorbol myristate acetate, and cigarette smoke; the suppression was not cell type-specific because both inducible and constitutive NF-kappaB activation was inhibited.	Vorinostat	143-147	interleukin 1 beta	Homo sapiens	196-204
16385087-4	2006	METHODS AND RESULTS: Metformin dose-dependently inhibited IL-1beta-induced release of the pro-inflammatory cytokines IL-6 and IL-8 in ECs, SMCs, and Mphis.	Metformin	21-30	interleukin 1 beta	Homo sapiens	58-66
16299051-0	2006	Regulatory features of interleukin-1beta-mediated prostaglandin E2 synthesis in airway smooth muscle.	Dinoprostone	50-66	interleukin 1 beta	Homo sapiens	23-40
16299051-1	2006	Exposure of airway smooth muscle (ASM) cells to the cytokine IL-1beta results in an induction of PGE2 synthesis that affects numerous cell functions.	Dinoprostone	97-101	interleukin 1 beta	Homo sapiens	61-69
16299051-3	2006	To explore other putative regulatory features we examined the role of phospholipase A2 (PLA2) and PGE synthase (PGES) enzymes in IL-1beta-induced PGE2 production.	Dinoprostone	146-150	interleukin 1 beta	Homo sapiens	129-137
16299051-7	2006	SB-202474, an SB-203580 analog lacking the ability to inhibit p38 but capable of inhibiting IL-1beta-induced PGE2 production, was effective in inhibiting mPGES but not COX-2 or cPLA2 induction.	SB202494	0-9	interleukin 1 beta	Homo sapiens	92-100
16299051-7	2006	SB-202474, an SB-203580 analog lacking the ability to inhibit p38 but capable of inhibiting IL-1beta-induced PGE2 production, was effective in inhibiting mPGES but not COX-2 or cPLA2 induction.	Dinoprostone	109-113	interleukin 1 beta	Homo sapiens	92-100
16299051-9	2006	mPGES induction and, possibly, cPLA2 induction appear to cooperate with COX-2 to determine IL-1beta-mediated PGE2 production in human ASM cells.	Dinoprostone	109-113	interleukin 1 beta	Homo sapiens	91-99
16508938-5	2006	We investigated the effects of S1P on proliferation by WST-1 assay, and its effects on tumor necrosis factor alpha (TNFalpha)- or interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production in RA synoviocytes and MH7A cells by Western blotting and enzyme-linked immunosorbent assay, respectively.	Dinoprostone	207-223	interleukin 1 beta	Homo sapiens	130-147
16234266-3	2006	We demonstrate that the molecular inhibition of histone deacetylation, using trichostatin A (TSA), in human choriodecidual explants leads to a massive increase in lipopolysaccharide (LPS)-stimulated IL-1beta.	trichostatin A	77-91	interleukin 1 beta	Homo sapiens	199-207
16234266-3	2006	We demonstrate that the molecular inhibition of histone deacetylation, using trichostatin A (TSA), in human choriodecidual explants leads to a massive increase in lipopolysaccharide (LPS)-stimulated IL-1beta.	trichostatin A	93-96	interleukin 1 beta	Homo sapiens	199-207
15993884-8	2006	OxLDLsup could induce both interleukin (IL)-1beta and IL-12 secretion in naive macrophages.	oxldlsup	0-8	interleukin 1 beta	Homo sapiens	27-49
16385087-5	2006	Investigation of potential signaling pathways demonstrated that metformin diminished IL-1beta-induced activation and nuclear translocation of nuclear factor-kappa B (NF-kappaB) in SMCs.	Metformin	64-73	interleukin 1 beta	Homo sapiens	85-93
16508938-5	2006	We investigated the effects of S1P on proliferation by WST-1 assay, and its effects on tumor necrosis factor alpha (TNFalpha)- or interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production in RA synoviocytes and MH7A cells by Western blotting and enzyme-linked immunosorbent assay, respectively.	Dinoprostone	207-223	interleukin 1 beta	Homo sapiens	149-157
16508938-5	2006	We investigated the effects of S1P on proliferation by WST-1 assay, and its effects on tumor necrosis factor alpha (TNFalpha)- or interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production in RA synoviocytes and MH7A cells by Western blotting and enzyme-linked immunosorbent assay, respectively.	Dinoprostone	225-229	interleukin 1 beta	Homo sapiens	130-147
16508938-5	2006	We investigated the effects of S1P on proliferation by WST-1 assay, and its effects on tumor necrosis factor alpha (TNFalpha)- or interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production in RA synoviocytes and MH7A cells by Western blotting and enzyme-linked immunosorbent assay, respectively.	Dinoprostone	225-229	interleukin 1 beta	Homo sapiens	149-157
16508938-11	2006	Moreover, S1P enhanced expression of COX-2 and production of PGE2 induced by stimulation with TNFalpha or IL-1beta in RA synoviocytes and MH7A cells.	Dinoprostone	61-65	interleukin 1 beta	Homo sapiens	106-114
16385087-6	2006	Furthermore, metformin suppressed IL-1beta-induced activation of the pro-inflammatory phosphokinases Akt, p38, and Erk, but did not affect PI3 kinase (PI3K) activity.	Metformin	13-22	interleukin 1 beta	Homo sapiens	34-42
16491333-4	2006	As an example, released inflammatory cytokines (e.g., interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)), activated in up-stream macrophages, flow through a microfluidic mixing system, generating linear concentration gradients in down-stream wells and inducing down-stream osteoblasts to release prostaglandin E2 (PGE2), a well-known bone resorption marker.	Dinoprostone	339-343	interleukin 1 beta	Homo sapiens	54-72
16491333-4	2006	As an example, released inflammatory cytokines (e.g., interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)), activated in up-stream macrophages, flow through a microfluidic mixing system, generating linear concentration gradients in down-stream wells and inducing down-stream osteoblasts to release prostaglandin E2 (PGE2), a well-known bone resorption marker.	Dinoprostone	321-337	interleukin 1 beta	Homo sapiens	54-72
16491333-4	2006	As an example, released inflammatory cytokines (e.g., interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)), activated in up-stream macrophages, flow through a microfluidic mixing system, generating linear concentration gradients in down-stream wells and inducing down-stream osteoblasts to release prostaglandin E2 (PGE2), a well-known bone resorption marker.	Dinoprostone	339-343	interleukin 1 beta	Homo sapiens	74-83
16491333-4	2006	As an example, released inflammatory cytokines (e.g., interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)), activated in up-stream macrophages, flow through a microfluidic mixing system, generating linear concentration gradients in down-stream wells and inducing down-stream osteoblasts to release prostaglandin E2 (PGE2), a well-known bone resorption marker.	Dinoprostone	321-337	interleukin 1 beta	Homo sapiens	74-83
16354768-0	2006	Janus kinase-signal transducer and activator of transcription mediates phosphatidic acid-induced interleukin (IL)-1beta and IL-6 production.	Phosphatidic Acids	71-88	interleukin 1 beta	Homo sapiens	97-119
16428068-12	2006	Moreover, NS-398 suppressed the anti-apoptotic activity of IL-8 and IL-1beta, but did not induce COX-2; therefore, the pro-apoptotic mechanism of the selective COX-2 inhibitor may be unrelated to COX-2 activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	10-16	interleukin 1 beta	Homo sapiens	68-76
16222709-6	2006	Using patch clamp, we observe that IL-1beta treatment (10 ng/ml, 24 h) suppresses LCC currents by approximately 38%, which made up half of the whole-cell Ca2+ current determined by nifedipine.	[(1R,3R,4R,7S)-7-HYDROXY-3-(5-METHYLCYTOSIN-1-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL DIHYDROGEN PHOSPHATE	82-85	interleukin 1 beta	Homo sapiens	35-43
16222709-6	2006	Using patch clamp, we observe that IL-1beta treatment (10 ng/ml, 24 h) suppresses LCC currents by approximately 38%, which made up half of the whole-cell Ca2+ current determined by nifedipine.	Nifedipine	181-191	interleukin 1 beta	Homo sapiens	35-43
16319216-0	2006	Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons.	Sodium	57-63	interleukin 1 beta	Homo sapiens	8-16
16319216-2	2006	To better understand such molecular and cellular mechanisms, we investigated how IL-1beta modulates the total voltage-dependent sodium currents (INa) and its tetrodotoxin-resistant (TTX-R) component in capsaicin-sensitive trigeminal nociceptive neurons, both after a brief (5-min) and after a chronic exposure (24-h) of 20 ng/ml IL-1beta.	Sodium	128-134	interleukin 1 beta	Homo sapiens	81-89
16319216-2	2006	To better understand such molecular and cellular mechanisms, we investigated how IL-1beta modulates the total voltage-dependent sodium currents (INa) and its tetrodotoxin-resistant (TTX-R) component in capsaicin-sensitive trigeminal nociceptive neurons, both after a brief (5-min) and after a chronic exposure (24-h) of 20 ng/ml IL-1beta.	Tetrodotoxin	158-170	interleukin 1 beta	Homo sapiens	81-89
16319216-2	2006	To better understand such molecular and cellular mechanisms, we investigated how IL-1beta modulates the total voltage-dependent sodium currents (INa) and its tetrodotoxin-resistant (TTX-R) component in capsaicin-sensitive trigeminal nociceptive neurons, both after a brief (5-min) and after a chronic exposure (24-h) of 20 ng/ml IL-1beta.	Capsaicin	202-211	interleukin 1 beta	Homo sapiens	81-89
16054696-5	2006	Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells.	Pravastatin	19-30	interleukin 1 beta	Homo sapiens	163-171
16054696-5	2006	Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells.	Pravastatin	19-30	interleukin 1 beta	Homo sapiens	302-310
16054696-5	2006	Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells.	Simvastatin	35-46	interleukin 1 beta	Homo sapiens	163-171
16054696-5	2006	Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells.	Simvastatin	35-46	interleukin 1 beta	Homo sapiens	302-310
16054696-5	2006	Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells.	Nitric Oxide	176-188	interleukin 1 beta	Homo sapiens	163-171
16054696-5	2006	Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells.	Nitroprusside	201-221	interleukin 1 beta	Homo sapiens	163-171
16095699-3	2006	Within the enhancer, three transcription factor binding sites, previously demonstrated by us to be important for the induction of IL1B by lipopolysaccharide, are now shown to be directly inhibited by the synthetic glucocorticoid, dexamethasone.	Dexamethasone	230-243	interleukin 1 beta	Homo sapiens	130-134
16462527-4	2006	Basic calcium phosphate crystals have also been found to upregulate IL-1beta in fibroblasts and chondrocytes.	basic calcium phosphate	0-23	interleukin 1 beta	Homo sapiens	68-76
16462527-9	2006	SUMMARY: Recent findings have emphasized the potential for basic calcium phosphate crystals to stimulate the production of a variety of inflammatory mediators such as prostaglandin E(2), nitric oxide, IL-1beta and matrix metalloproteinases, and have helped to elucidate the mechanisms of these effects.	basic calcium phosphate	59-82	interleukin 1 beta	Homo sapiens	201-209
16736416-11	2006	The urinary FE of IL-1 was 1.2 +/- 0.6% in NRF, and 1.0 +/- 0.4% in NOARF (ns), the FE of IL-6 was 1.4 +/- 0.8% in NRF and 1.3 +/- 0.3% in NOARF (ns).	Iron	12-14	interleukin 1 beta	Homo sapiens	18-22
16736416-13	2006	Urinary excretion of IL-6 was significantly related with urinary IL-1 beta, both expressed as pg/ml/mg of urinary creatinine (r=0.85, p&lt;0.0001).	Creatinine	114-124	interleukin 1 beta	Homo sapiens	65-74
16317111-5	2006	In addition, fluvastatin increased IL-1beta-induced p65 nuclear translocation and nuclear factor kappaB (NF-kappaB) activity, although it inhibited those induced by LPS.	Fluvastatin	13-24	interleukin 1 beta	Homo sapiens	35-43
16317111-7	2006	We found that Y-27632 potentiated IL-1beta-induced iNOS expression, p65 nuclear translocation, IkappaB kinase (IKK), and NF-kappaB activation, whereas it had minimal effects on LPS-induced responses.	Y 27632	14-21	interleukin 1 beta	Homo sapiens	34-42
16354768-7	2006	The knockdown of JAK2 in macrophages by small interfering RNA significantly attenuated PA-induced IL-1beta and IL-6 production.	Phosphatidic Acids	87-89	interleukin 1 beta	Homo sapiens	98-106
16354768-9	2006	Together, our data demonstrate that PA-activated macrophages produce IL-1beta and IL-6 and that these processes require the activation of the JAK2-STAT1/3 or JAK2-Akt-STAT signaling pathways.	Phosphatidic Acids	36-38	interleukin 1 beta	Homo sapiens	69-77
16354768-2	2006	In the present study, we provide evidence of the PA-mediated activation of the Janus tyrosine kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, which results in the production of interleukin (IL)-1beta and IL-6.	Phosphatidic Acids	49-51	interleukin 1 beta	Homo sapiens	217-239
16354768-5	2006	Of the inflammatory cytokines, IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha were detected in media from macrophages stimulated with PA.	Phosphatidic Acids	141-143	interleukin 1 beta	Homo sapiens	31-39
16354768-6	2006	Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	29-74	interleukin 1 beta	Homo sapiens	105-113
16354768-6	2006	Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	29-74	interleukin 1 beta	Homo sapiens	202-210
16354768-6	2006	Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	76-82	interleukin 1 beta	Homo sapiens	105-113
16354768-6	2006	Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	76-82	interleukin 1 beta	Homo sapiens	202-210
16354768-6	2006	Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region.	Phosphatidic Acids	94-96	interleukin 1 beta	Homo sapiens	105-113
16354768-6	2006	Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region.	Phosphatidic Acids	94-96	interleukin 1 beta	Homo sapiens	202-210
16397875-5	2006	The mean values of IL-1beta, IL-8, and IL-10 at T4 were lower in the HFOV group than in the PSV + VG group.	hfov	69-73	interleukin 1 beta	Homo sapiens	19-27
16499573-10	2006	We also observed that throughout C. trachomatis persistence induced by doxycycline (Dox) treatment, IL-1beta, IL-6, IL-8 and TNF-alpha expression was reduced, whereas the synthesis of IL-10 and IL-12p70 remained unchanged but not sustained.	Doxycycline	71-82	interleukin 1 beta	Homo sapiens	100-108
16499573-10	2006	We also observed that throughout C. trachomatis persistence induced by doxycycline (Dox) treatment, IL-1beta, IL-6, IL-8 and TNF-alpha expression was reduced, whereas the synthesis of IL-10 and IL-12p70 remained unchanged but not sustained.	Doxycycline	84-87	interleukin 1 beta	Homo sapiens	100-108
16477012-6	2006	The effects of PDGF/IL-1beta costimulation on contractile marker expression and Akt and p70S6K phosphorylation were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 and by adenovirus expressing a dominant-negative Akt, and they were mimicked by constitutively active Akt.	Wortmannin	172-182	interleukin 1 beta	Homo sapiens	20-28
16477012-6	2006	The effects of PDGF/IL-1beta costimulation on contractile marker expression and Akt and p70S6K phosphorylation were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 and by adenovirus expressing a dominant-negative Akt, and they were mimicked by constitutively active Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	interleukin 1 beta	Homo sapiens	20-28
16477014-0	2006	Ceramide mediates the rapid phase of febrile response to IL-1beta.	Ceramides	0-8	interleukin 1 beta	Homo sapiens	57-65
16477014-2	2006	It acts by inducing synthesis of prostaglandin E2, which mediates the late phase of IL-1beta-induced fever.	Dinoprostone	33-49	interleukin 1 beta	Homo sapiens	84-92
16630108-6	2006	In addition, interleukin-1beta and interferon-gamma exerted a proliferative effect on HPMC.	hydroxypropylmethylcellulose-lactose matrix	86-90	interleukin 1 beta	Homo sapiens	13-30
16630108-8	2006	Our data indicate that the response of HPMC to inflammatory injury is regulated by interleukin-1beta and TNF-alpha reflecting their putative role in peritoneal wound healing and adhesion formation.	hydroxypropylmethylcellulose-lactose matrix	39-43	interleukin 1 beta	Homo sapiens	83-100
16477014-3	2006	Here we show by radiotelemetry that the early phase of the fever response to IL-1beta is mediated by ceramide.	Ceramides	101-109	interleukin 1 beta	Homo sapiens	77-85
16477014-4	2006	Hypothalamic application of the cell-penetrating C2-ceramide mimics the rapid phase of the IL-1beta-induced fever.	N-acetylsphingosine	49-60	interleukin 1 beta	Homo sapiens	91-99
16477014-6	2006	Electrophysiological experiments on preoptic area/anterior hypothalamic neurons show that C2-ceramide, but not dihydroceramide, mimics the rapid hyperpolarizing effects of IL-1beta on the activity of warm-sensitive hypothalamic neurons.	N-acetylsphingosine	90-101	interleukin 1 beta	Homo sapiens	172-180
16477014-7	2006	IL-1beta-mediated hyperpolarization is blocked by PP2, the selective inhibitor of the protein tyrosine kinase Src, which is known to be activated by ceramide.	Ceramides	149-157	interleukin 1 beta	Homo sapiens	0-8
16448183-3	2006	Stevioside at 1 mM significantly suppressed lipopolysaccharide (LPS)-induced release of TNF-alpha and IL-1beta and slightly suppressed nitric oxide release in THP-1 cells without exerting any direct toxic effect, whereas steviol at 100 microM did not.	stevioside	0-10	interleukin 1 beta	Homo sapiens	102-110
16448183-5	2006	Furthermore, only stevioside induced TNF-alpha, IL-1beta, and nitric oxide release in unstimulated THP-1 cells.	stevioside	18-28	interleukin 1 beta	Homo sapiens	48-56
16452198-10	2006	LY294002 also significantly inhibited the arachidonic acid-induced gene expression of COX-2, IL-1beta, GM-CSF, and ICAM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Homo sapiens	93-101
16436856-8	2006	Perineural clonidine, but not saline, partially reversed the hypersensitivity, accompanied by reduced concentrations of interleukin 6 and interleukin 1beta in the sciatic nerve.	Clonidine	11-20	interleukin 1 beta	Homo sapiens	138-155
16452236-11	2006	Taken together, the data suggest that CDK2 activity may play an important event in the IL-1beta-induced COX-2 expression and prostaglandin E(2) synthesis and might represent a novel target for BMS-387032.	Dinoprostone	125-143	interleukin 1 beta	Homo sapiens	87-95
16452198-10	2006	LY294002 also significantly inhibited the arachidonic acid-induced gene expression of COX-2, IL-1beta, GM-CSF, and ICAM1.	Arachidonic Acid	42-58	interleukin 1 beta	Homo sapiens	93-101
16390820-3	2006	We aimed to investigate whether edaravone suppressed in vitro proliferation and migration of synovial cells (SC) induced by IL-1beta.	Edaravone	32-41	interleukin 1 beta	Homo sapiens	124-132
16390820-4	2006	SC proliferation and migration induced by IL-1beta were dose-dependently suppressed by edaravone at the clinically available concentration.	Edaravone	87-96	interleukin 1 beta	Homo sapiens	42-50
16106402-0	2006	Ursodeoxycholic acid inhibits interleukin 1 beta [corrected] and deoxycholic acid-induced activation of NF-kappaB and AP-1 in human colon cancer cells.	Ursodeoxycholic Acid	0-20	interleukin 1 beta	Homo sapiens	30-48
16106402-0	2006	Ursodeoxycholic acid inhibits interleukin 1 beta [corrected] and deoxycholic acid-induced activation of NF-kappaB and AP-1 in human colon cancer cells.	Deoxycholic Acid	4-20	interleukin 1 beta	Homo sapiens	30-48
16399619-2	2006	In human primary chondrocytes, the production of matrix metalloproteinase-13 and -1 (MMP-13 and -1) and prostaglandin E2 (PGE2) was induced by interleukin-1beta.	Dinoprostone	104-120	interleukin 1 beta	Homo sapiens	143-160
16269458-9	2006	MG-132, a proteasome inhibitor that blocked degradation of the intrinsic NFkappaB inhibitor, IkappaB, and thereby prevented NFkappaB activation, was a potent inhibitor of both TNFalpha- and IL-1beta-stimulated PAPP-A mRNA and protein expression and IGF binding protein-4 protease activity.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-6	interleukin 1 beta	Homo sapiens	190-198
16269458-8	2006	However, SP600125 effectively inhibited IL-1beta-induced PAPP-A protein expression.	pyrazolanthrone	9-17	interleukin 1 beta	Homo sapiens	40-48
16399619-2	2006	In human primary chondrocytes, the production of matrix metalloproteinase-13 and -1 (MMP-13 and -1) and prostaglandin E2 (PGE2) was induced by interleukin-1beta.	Dinoprostone	122-126	interleukin 1 beta	Homo sapiens	143-160
16269458-11	2006	BAY11-7082, another inhibitor of NFkappaB activation, also inhibited TNFalpha- and IL-1beta-stimulated PAPP-A expression and IGF binding protein-4 protease activity.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-10	interleukin 1 beta	Homo sapiens	83-91
16451750-5	2006	The 1,3,5-triazines tested inhibited the adhesion evoked by pro-inflammatory stimuli, such as platelet activating factor (PAF), FMLP, phorbol myristate acetate (PMA), tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta(IL-1beta) in a dose-response manner over the concentration range 10(-9) to 10(-4)M, compounds 5 and 6 being the most active.	1,3,5-triazines	4-19	interleukin 1 beta	Homo sapiens	212-229
16399631-6	2006	Further studies revealed that oridonin induced IkappaBalpha degradation, which was prevented by Ras inhibitor manumycin A, ERK inhibitor PD98059, but not prevented by c-Jun N-terminal kinase (JNK) MAPK inhibitor SP600125, and up-regulated expression of IL-1beta precursor.	oridonin	30-38	interleukin 1 beta	Homo sapiens	253-261
16399631-7	2006	These results demonstrate that Ras/Raf1/ERK signaling pathway-dependent IkappaBalpha degradation, resulting in NF-kappaB activation, participates in regulation of oridonin-enhanced phagocytosis, and one of its effector functions is to induce synthesis of IL-1beta, which partially contribute to phagocytic activity of oridonin.	oridonin	163-171	interleukin 1 beta	Homo sapiens	255-263
16405508-8	2006	Our data suggest that PGE2 signaling in the brain may be altered after IL-1beta release due to up-regulation of EP3 receptors.	Dinoprostone	22-26	interleukin 1 beta	Homo sapiens	71-79
16405508-9	2006	This might play an important role in acute and chronic conditions such as cerebral ischemia, traumatic brain injury, HIV-encephalitis, Alzheimer"s disease and prion diseases in which a marked up-regulation of IL-1beta is followed by a prolonged increase of PGE2 levels in the brain.	Dinoprostone	257-261	interleukin 1 beta	Homo sapiens	209-217
16399631-2	2006	We have reported that oridonin isolated from Rabdosia rubescens enhanced phagocytosis of apoptotic U937 cells by macrophage-like U937 cells through TNFalpha and IL-1beta release.	oridonin	22-30	interleukin 1 beta	Homo sapiens	161-169
16451750-5	2006	The 1,3,5-triazines tested inhibited the adhesion evoked by pro-inflammatory stimuli, such as platelet activating factor (PAF), FMLP, phorbol myristate acetate (PMA), tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta(IL-1beta) in a dose-response manner over the concentration range 10(-9) to 10(-4)M, compounds 5 and 6 being the most active.	1,3,5-triazines	4-19	interleukin 1 beta	Homo sapiens	230-238
16338461-1	2006	OBJECTIVE: To investigate the interaction of dexamethasone and interleukin-1beta (IL-1beta) on the expression of cytosolic phospholipase A(2) (cPLA(2)), the enzyme catalyzing the first reaction in the formation of prostaglandins, in cultured primary human amnion fibroblasts.	Prostaglandins	214-228	interleukin 1 beta	Homo sapiens	63-80
16338461-8	2006	The interaction between dexamethasone and IL-1beta on prostaglandin synthesis and cPLA(2) expression is neither synergistic nor conventionally antagonistic.	Prostaglandins	54-67	interleukin 1 beta	Homo sapiens	42-50
16338461-1	2006	OBJECTIVE: To investigate the interaction of dexamethasone and interleukin-1beta (IL-1beta) on the expression of cytosolic phospholipase A(2) (cPLA(2)), the enzyme catalyzing the first reaction in the formation of prostaglandins, in cultured primary human amnion fibroblasts.	Prostaglandins	214-228	interleukin 1 beta	Homo sapiens	82-90
16338461-4	2006	RESULTS: Both dexamethasone and IL-1beta caused a significant increase in prostaglandin E(2) output, cPLA(2) mRNA and protein expression in cultured human amnion fibroblasts.	Dinoprostone	74-92	interleukin 1 beta	Homo sapiens	32-40
16584593-4	2006	The results indicated that after treatment with PS-341 the expressions of IL-6, IL-1beta and SCF of MSCs decreased markedly, especially that of IL-1beta, compared with control (P &lt; 0.05, P &lt; 0.01, P &lt; 0.05, respectively).	Bortezomib	48-54	interleukin 1 beta	Homo sapiens	80-88
16584593-4	2006	The results indicated that after treatment with PS-341 the expressions of IL-6, IL-1beta and SCF of MSCs decreased markedly, especially that of IL-1beta, compared with control (P &lt; 0.05, P &lt; 0.01, P &lt; 0.05, respectively).	Bortezomib	48-54	interleukin 1 beta	Homo sapiens	144-152
16584593-5	2006	There were obviously differences of IL-1beta expression between refractory/relapsed group and complete remission (CR) group and IL-1beta expression was inhibited more seriously in CR group, whereas there were no significant differences of IL-6 and SCF expression between two groups; IL-1beta expression of patients treated with PS-341 was not detected; there were not effects of IL-1beta expression on expressions of IL-6 and SCF.	Chromium	114-116	interleukin 1 beta	Homo sapiens	36-44
16584593-5	2006	There were obviously differences of IL-1beta expression between refractory/relapsed group and complete remission (CR) group and IL-1beta expression was inhibited more seriously in CR group, whereas there were no significant differences of IL-6 and SCF expression between two groups; IL-1beta expression of patients treated with PS-341 was not detected; there were not effects of IL-1beta expression on expressions of IL-6 and SCF.	Chromium	114-116	interleukin 1 beta	Homo sapiens	128-136
16584593-5	2006	There were obviously differences of IL-1beta expression between refractory/relapsed group and complete remission (CR) group and IL-1beta expression was inhibited more seriously in CR group, whereas there were no significant differences of IL-6 and SCF expression between two groups; IL-1beta expression of patients treated with PS-341 was not detected; there were not effects of IL-1beta expression on expressions of IL-6 and SCF.	Chromium	114-116	interleukin 1 beta	Homo sapiens	128-136
16584593-5	2006	There were obviously differences of IL-1beta expression between refractory/relapsed group and complete remission (CR) group and IL-1beta expression was inhibited more seriously in CR group, whereas there were no significant differences of IL-6 and SCF expression between two groups; IL-1beta expression of patients treated with PS-341 was not detected; there were not effects of IL-1beta expression on expressions of IL-6 and SCF.	Chromium	114-116	interleukin 1 beta	Homo sapiens	128-136
16584593-6	2006	It is concluded that proteasome inhibitor PS-341 downregulated the expressions of IL-6, IL-1beta and SCF of MSCs in patients with MM.	Bortezomib	42-48	interleukin 1 beta	Homo sapiens	88-96
16286467-0	2006	Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.	Hydrogen Peroxide	66-70	interleukin 1 beta	Homo sapiens	0-17
16441896-8	2006	COX-inhibitors (indomethacin and NS-398) markedly decreased IL-1beta-stimulated secretion of BDNF, but not IL-1beta-stimulated NGF secretion.	Indomethacin	16-28	interleukin 1 beta	Homo sapiens	60-68
16441896-8	2006	COX-inhibitors (indomethacin and NS-398) markedly decreased IL-1beta-stimulated secretion of BDNF, but not IL-1beta-stimulated NGF secretion.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	33-39	interleukin 1 beta	Homo sapiens	60-68
16286467-8	2006	Recruitment of NIK to TRAF6 following IL-1beta stimulation was inhibited by H2O2 clearance and Rac1 siRNA, suggesting that Rac-dependent NADPH oxidase may be a source of ROS required for NIK activation.	Hydrogen Peroxide	76-80	interleukin 1 beta	Homo sapiens	38-46
16286467-3	2006	In the present report, we describe a mechanism whereby interleukin-1beta (IL-1beta) stimulation of NFkappaB is partially regulated by H2O2-mediated activation of NIK and subsequent NIK-mediated phosphorylation of IKKalpha.	Hydrogen Peroxide	134-138	interleukin 1 beta	Homo sapiens	55-72
16286467-8	2006	Recruitment of NIK to TRAF6 following IL-1beta stimulation was inhibited by H2O2 clearance and Rac1 siRNA, suggesting that Rac-dependent NADPH oxidase may be a source of ROS required for NIK activation.	Reactive Oxygen Species	170-173	interleukin 1 beta	Homo sapiens	38-46
16286467-3	2006	In the present report, we describe a mechanism whereby interleukin-1beta (IL-1beta) stimulation of NFkappaB is partially regulated by H2O2-mediated activation of NIK and subsequent NIK-mediated phosphorylation of IKKalpha.	Hydrogen Peroxide	134-138	interleukin 1 beta	Homo sapiens	74-82
16286467-9	2006	In summary, our studies have demonstrated that redox regulation of NIK by H2O2 is mechanistically important in IL-1beta induction of NFkappaB activation.	Hydrogen Peroxide	74-78	interleukin 1 beta	Homo sapiens	111-119
16286467-4	2006	IL-1beta induced H2O2 production in MCF-7 cells and clearance of this ROS through the expression of GPx-1 reduced NFkappaB transcriptional activation by inhibiting NIK-mediated phosphorylation of IKKalpha.	Hydrogen Peroxide	17-21	interleukin 1 beta	Homo sapiens	0-8
16286467-4	2006	IL-1beta induced H2O2 production in MCF-7 cells and clearance of this ROS through the expression of GPx-1 reduced NFkappaB transcriptional activation by inhibiting NIK-mediated phosphorylation of IKKalpha.	Reactive Oxygen Species	70-73	interleukin 1 beta	Homo sapiens	0-8
16297873-1	2006	Mechanical loading can counteract inflammatory pathways induced by IL-1beta by inhibiting *NO and PGE2, catabolic mediators known to be involved in cartilage degradation.	Dinoprostone	98-102	interleukin 1 beta	Homo sapiens	67-75
16002276-1	2006	Sputtered silicon nitride optical waveguide surfaces were silanized and modified with a hetero-bifunctional crosslinker to facilitate thiol-reactive immobilization of contact-printed DNA probe oligonucleotides, streptavidin and murine anti-human interleukin-1 beta capture agents in microarray formats.	silicon nitride	10-25	interleukin 1 beta	Homo sapiens	246-264
16002276-1	2006	Sputtered silicon nitride optical waveguide surfaces were silanized and modified with a hetero-bifunctional crosslinker to facilitate thiol-reactive immobilization of contact-printed DNA probe oligonucleotides, streptavidin and murine anti-human interleukin-1 beta capture agents in microarray formats.	Sulfhydryl Compounds	134-139	interleukin 1 beta	Homo sapiens	246-264
16002276-5	2006	Non-thiolated anti-human interleukin-1 beta printed on modified silicon nitride surfaces reactive to thiol chemistry exhibited comparable performance for capturing human interleukin-1 beta analyte to commercial amine-reactive microarraying polymer surfaces in sandwich immunoassays, indicating substantial non-specific antibody-surface capture responsible for analyte capture signal.	silicon nitride	64-79	interleukin 1 beta	Homo sapiens	25-43
16002276-5	2006	Non-thiolated anti-human interleukin-1 beta printed on modified silicon nitride surfaces reactive to thiol chemistry exhibited comparable performance for capturing human interleukin-1 beta analyte to commercial amine-reactive microarraying polymer surfaces in sandwich immunoassays, indicating substantial non-specific antibody-surface capture responsible for analyte capture signal.	Sulfhydryl Compounds	4-9	interleukin 1 beta	Homo sapiens	25-43
16002276-5	2006	Non-thiolated anti-human interleukin-1 beta printed on modified silicon nitride surfaces reactive to thiol chemistry exhibited comparable performance for capturing human interleukin-1 beta analyte to commercial amine-reactive microarraying polymer surfaces in sandwich immunoassays, indicating substantial non-specific antibody-surface capture responsible for analyte capture signal.	Sulfhydryl Compounds	4-9	interleukin 1 beta	Homo sapiens	170-188
16002276-5	2006	Non-thiolated anti-human interleukin-1 beta printed on modified silicon nitride surfaces reactive to thiol chemistry exhibited comparable performance for capturing human interleukin-1 beta analyte to commercial amine-reactive microarraying polymer surfaces in sandwich immunoassays, indicating substantial non-specific antibody-surface capture responsible for analyte capture signal.	Amines	211-216	interleukin 1 beta	Homo sapiens	25-43
16002276-5	2006	Non-thiolated anti-human interleukin-1 beta printed on modified silicon nitride surfaces reactive to thiol chemistry exhibited comparable performance for capturing human interleukin-1 beta analyte to commercial amine-reactive microarraying polymer surfaces in sandwich immunoassays, indicating substantial non-specific antibody-surface capture responsible for analyte capture signal.	Polymers	240-247	interleukin 1 beta	Homo sapiens	25-43
16297873-4	2006	When provided in combination, IL-4 and dynamic compression could further abrogate the IL-1beta induced nitrite and PGE2 release.	Dinoprostone	115-119	interleukin 1 beta	Homo sapiens	86-94
16297873-5	2006	IL-1beta inhibited [3H]thymidine incorporation and this effect could be reversed by IL-4 or dynamic strain alone or both in combination.	Tritium	20-22	interleukin 1 beta	Homo sapiens	0-8
16297873-5	2006	IL-1beta inhibited [3H]thymidine incorporation and this effect could be reversed by IL-4 or dynamic strain alone or both in combination.	Thymidine	23-32	interleukin 1 beta	Homo sapiens	0-8
16297873-3	2006	The data presented demonstrate that IL-4 alone can inhibit nitrite release in the presence and absence of IL-1beta and partially reverse the IL-1beta induced PGE2 release.	Dinoprostone	158-162	interleukin 1 beta	Homo sapiens	141-149
16297873-4	2006	When provided in combination, IL-4 and dynamic compression could further abrogate the IL-1beta induced nitrite and PGE2 release.	Nitrites	103-110	interleukin 1 beta	Homo sapiens	86-94
16399681-5	2006	Intracerebral infusion with the nitric oxide donor sodium nitroprusside (SNP) caused neurodegeneration and demyelination that were markedly increased in the brain of TNF-alpha- and IL-1beta/TNF-alpha-deficient mice compared with IL-1beta-deficient and wild-type mice.	Nitric Oxide	32-44	interleukin 1 beta	Homo sapiens	181-189
16399681-5	2006	Intracerebral infusion with the nitric oxide donor sodium nitroprusside (SNP) caused neurodegeneration and demyelination that were markedly increased in the brain of TNF-alpha- and IL-1beta/TNF-alpha-deficient mice compared with IL-1beta-deficient and wild-type mice.	Nitroprusside	51-71	interleukin 1 beta	Homo sapiens	181-189
16373510-6	2006	Cytochalasin D blocked the Francisella internalization and the Francisella-induced monocyte IL-1beta processing and release but not that induced by the exogenous stimulus E. coli LPS.	Cytochalasin D	0-14	interleukin 1 beta	Homo sapiens	92-100
16433741-8	2006	RESULTS: Eighteen hours after moderate alcohol consumption, we found a significant reduction in monocyte production of inflammatory mediators, TNF-alpha and IL-1beta, in response to LPS or staphylococcal enterotoxin B stimulation.	Alcohols	39-46	interleukin 1 beta	Homo sapiens	157-165
16433741-9	2006	Acute alcohol consumption inhibited LPS-induced DNA binding of the p65/p50 NF-kappaB in monocytes that regulates the expression of both the TNF-alpha and the IL-1beta genes.	Alcohols	6-13	interleukin 1 beta	Homo sapiens	158-166
16912431-6	2006	The present study was designed to evaluate in vitro effects of diacerein on IL-1beta expression in LPS or IL-1alpha stimulated chondrocytes.	diacerein	63-72	interleukin 1 beta	Homo sapiens	76-84
16338976-7	2006	Interestingly, pretreatment of hCASMC with resveratrol, a polyphenol found in the skin of grapes and in red wine purported to underlie the "French paradox," inhibited TNF-alpha- and IL-1beta-induced PAPP-A expression and, hence, its IGFBP-4 proteolytic activity.	Resveratrol	43-54	interleukin 1 beta	Homo sapiens	182-190
16912414-0	2006	Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs.	Sepharose	107-114	interleukin 1 beta	Homo sapiens	32-40
16859503-7	2006	Adhered monocytes, after 3-day preincubation with IL-10 and M-CSF, could produce more IL-1beta and IL-6 in response to TNF-alpha in the presence of dibutyryl cAMP, as compared with the cells preincubated with or without IL-10 or M-CSF alone.	Cyclic AMP	158-162	interleukin 1 beta	Homo sapiens	86-94
16912414-4	2006	The current data demonstrate that IL-1beta induced nitrite and PGE2 release and inhibited [3H]-thymidine and 35SO4 incorporation.	Nitrites	51-58	interleukin 1 beta	Homo sapiens	34-42
16912414-4	2006	The current data demonstrate that IL-1beta induced nitrite and PGE2 release and inhibited [3H]-thymidine and 35SO4 incorporation.	Dinoprostone	63-67	interleukin 1 beta	Homo sapiens	34-42
16912414-2	2006	Both mechanical loading and IL-1beta will influence the release of *NO and PGE2.	Dinoprostone	75-79	interleukin 1 beta	Homo sapiens	28-36
16912414-4	2006	The current data demonstrate that IL-1beta induced nitrite and PGE2 release and inhibited [3H]-thymidine and 35SO4 incorporation.	Thymidine	90-104	interleukin 1 beta	Homo sapiens	34-42
16912431-7	2006	Intracellular IL-1beta production was analysed in articular chondrocytes cultured in monolayer or in alginate 3D-biosystems in the presence of lipopolysaccharide (LPS) or IL-1alpha, with or without diacerein.	Alginates	101-109	interleukin 1 beta	Homo sapiens	14-22
16912414-4	2006	The current data demonstrate that IL-1beta induced nitrite and PGE2 release and inhibited [3H]-thymidine and 35SO4 incorporation.	35so4	109-114	interleukin 1 beta	Homo sapiens	34-42
16912431-8	2006	The results show that LPS and IL-1alpha increase intracellular IL-1beta and Diacerein inhibited LPS-induced and IL-1alpha induced IL-1beta production by articular chondrocytes.	diacerein	76-85	interleukin 1 beta	Homo sapiens	130-138
16912414-5	2006	Inhibitor experiments indicate that 1400W and NS-398 either partially reversed or abolished IL-1beta induced nitrite and PGE2 release.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	36-41	interleukin 1 beta	Homo sapiens	92-100
16210363-0	2006	T helper type 1 and type 2 cytokines exert divergent influence on the induction of prostaglandin E2 and hyaluronan synthesis by interleukin-1beta in orbital fibroblasts: implications for the pathogenesis of thyroid-associated ophthalmopathy.	Dinoprostone	83-99	interleukin 1 beta	Homo sapiens	128-145
16912414-5	2006	Inhibitor experiments indicate that 1400W and NS-398 either partially reversed or abolished IL-1beta induced nitrite and PGE2 release.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	46-52	interleukin 1 beta	Homo sapiens	92-100
16912414-5	2006	Inhibitor experiments indicate that 1400W and NS-398 either partially reversed or abolished IL-1beta induced nitrite and PGE2 release.	Nitrites	109-116	interleukin 1 beta	Homo sapiens	92-100
16912414-5	2006	Inhibitor experiments indicate that 1400W and NS-398 either partially reversed or abolished IL-1beta induced nitrite and PGE2 release.	Dinoprostone	121-125	interleukin 1 beta	Homo sapiens	92-100
16912414-6	2006	IL-1beta induced inhibition of cell proliferation and proteoglycan synthesis was partially reversed with 1400W but was not influenced by NS-398.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	105-110	interleukin 1 beta	Homo sapiens	0-8
16912414-7	2006	For the dynamic loading experiments, 1400W and NS-398 either reduced or abolished the compression-induced inhibition of *NO and PGE2 release in the presence of IL-1beta.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	37-42	interleukin 1 beta	Homo sapiens	160-168
16912414-7	2006	For the dynamic loading experiments, 1400W and NS-398 either reduced or abolished the compression-induced inhibition of *NO and PGE2 release in the presence of IL-1beta.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	47-53	interleukin 1 beta	Homo sapiens	160-168
16912414-8	2006	The IL-1beta induced inhibition of cell proliferation was not influenced by 1400W or NS-398 whereas strain-induced stimulation of proteoglycan synthesis in the presence of IL-1beta was enhanced by 1400W.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	197-202	interleukin 1 beta	Homo sapiens	172-180
16912414-9	2006	The data obtained using human chondrocytes demonstrate that IL-1beta induced *NO and PGE2 release via an iNOS-driven-COX-2 inter-dependent pathway.	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	60-68
16210363-0	2006	T helper type 1 and type 2 cytokines exert divergent influence on the induction of prostaglandin E2 and hyaluronan synthesis by interleukin-1beta in orbital fibroblasts: implications for the pathogenesis of thyroid-associated ophthalmopathy.	Hyaluronic Acid	104-114	interleukin 1 beta	Homo sapiens	128-145
16210363-2	2006	At the heart of orbital susceptibility to Graves" disease appears to be the peculiar phenotype of orbital fibroblasts that, when activated by IL-1beta and other proinflammatory cytokines, produce excess prostaglandin E2 (PGE2) and hyaluronan.	Dinoprostone	203-219	interleukin 1 beta	Homo sapiens	142-150
16210363-5	2006	We report here that interferon-gamma and IL-4, representative of these respective classes of cytokines, attenuate IL-1beta-provoked PGE2 production.	Dinoprostone	132-136	interleukin 1 beta	Homo sapiens	114-122
16210363-10	2006	In contrast, the up-regulation of hyaluronan synthesis by IL-1beta is enhanced by either IL-4 or interferon-gamma.	Hyaluronic Acid	34-44	interleukin 1 beta	Homo sapiens	58-66
16146780-4	2006	Cotreatment with an inhibitor of IL-1 beta and TNF-alpha synthesis prevented stilbene estrogen-induced lesions.	Stilbenes	77-85	interleukin 1 beta	Homo sapiens	33-42
16146780-5	2006	In addition to direct effect of 17 beta-estradiol (E2) on mitochondria and redox cycling of catechol estrogens, E2-induced overexpression of IL-1 beta can produce an increase in the level of ROS.	Estradiol	32-49	interleukin 1 beta	Homo sapiens	141-150
16146780-5	2006	In addition to direct effect of 17 beta-estradiol (E2) on mitochondria and redox cycling of catechol estrogens, E2-induced overexpression of IL-1 beta can produce an increase in the level of ROS.	catechol	92-100	interleukin 1 beta	Homo sapiens	141-150
16146780-5	2006	In addition to direct effect of 17 beta-estradiol (E2) on mitochondria and redox cycling of catechol estrogens, E2-induced overexpression of IL-1 beta can produce an increase in the level of ROS.	ros	191-194	interleukin 1 beta	Homo sapiens	141-150
16146780-8	2006	These studies support that in addition to ovarian estrogens, mitogenic signals may also come from TNF-alpha and IL-1 beta-generated O2*- and hydrogen peroxide.	o2*-	132-136	interleukin 1 beta	Homo sapiens	112-121
16146780-8	2006	These studies support that in addition to ovarian estrogens, mitogenic signals may also come from TNF-alpha and IL-1 beta-generated O2*- and hydrogen peroxide.	Hydrogen Peroxide	141-158	interleukin 1 beta	Homo sapiens	112-121
16424787-6	2006	In cultured monocytic cells, atorvastatin (10 micromol/L) reduced EP-1/-3/-4 expression, along with COX-2, mPGES-1, MMP-9, and PGE2 levels elicited by IL-1beta and TNF-alpha.	Atorvastatin	29-41	interleukin 1 beta	Homo sapiens	151-159
16365456-4	2006	IL-1beta-induced TGF-beta1 protein secretion and mRNA expression were prevented by actinomycin D and were attenuated by the inhibitor of kappaB kinase 2 inhibitor AS602868 and the JNK inhibitor SP600125, suggesting a degree of transcriptional regulation mediated by the NF-kappaB and AP-1 pathways.	Dactinomycin	83-96	interleukin 1 beta	Homo sapiens	0-8
16244114-14	2006	IL-1beta and tumor necrosis factor alpha were also found to potentiate PGE-2 action.	Dinoprostone	71-76	interleukin 1 beta	Homo sapiens	0-8
16365456-4	2006	IL-1beta-induced TGF-beta1 protein secretion and mRNA expression were prevented by actinomycin D and were attenuated by the inhibitor of kappaB kinase 2 inhibitor AS602868 and the JNK inhibitor SP600125, suggesting a degree of transcriptional regulation mediated by the NF-kappaB and AP-1 pathways.	AS602868	163-171	interleukin 1 beta	Homo sapiens	0-8
16365456-4	2006	IL-1beta-induced TGF-beta1 protein secretion and mRNA expression were prevented by actinomycin D and were attenuated by the inhibitor of kappaB kinase 2 inhibitor AS602868 and the JNK inhibitor SP600125, suggesting a degree of transcriptional regulation mediated by the NF-kappaB and AP-1 pathways.	pyrazolanthrone	194-202	interleukin 1 beta	Homo sapiens	0-8
16761500-3	2006	The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-alpha serum levels in SLE patients.	chloroquine diphosphate	62-83	interleukin 1 beta	Homo sapiens	92-100
16408116-0	2006	Increased mesangial cell hyaluronan expression in lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta.	Hyaluronic Acid	25-35	interleukin 1 beta	Homo sapiens	107-115
16804330-3	2006	In all-trans-retinoic acid (atRA)-treated human aortic smooth muscle cells (AOSMC), significant increases in IL-1beta levels were observed, compared with untreated cells.	Tretinoin	3-26	interleukin 1 beta	Homo sapiens	109-117
16804330-3	2006	In all-trans-retinoic acid (atRA)-treated human aortic smooth muscle cells (AOSMC), significant increases in IL-1beta levels were observed, compared with untreated cells.	Tretinoin	28-32	interleukin 1 beta	Homo sapiens	109-117
16804330-5	2006	The results show that atRA-treated AOSMC express both the precursor (33 kDa) and the active form (17 kDa) of the IL-1beta protein.	Tretinoin	22-26	interleukin 1 beta	Homo sapiens	113-121
16804330-6	2006	atRA-treated carotid lesions showed significantly elevated IL-1beta mRNA levels (2.9 +/- 2.33) compared with untreated lesions (2.0 +/- 1.77; p &lt; 0.05).	Tretinoin	0-4	interleukin 1 beta	Homo sapiens	59-67
16354686-4	2006	Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated IL-1beta-dependent IKK and NF-kappaB activation.	Superoxides	18-28	interleukin 1 beta	Homo sapiens	100-108
16354686-4	2006	Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated IL-1beta-dependent IKK and NF-kappaB activation.	Hydrogen Peroxide	33-37	interleukin 1 beta	Homo sapiens	100-108
16354686-6	2006	Small interfering RNAs to either MyD88 or Rac1 inhibited IL-1beta induction of endosomal superoxide and NF-kappaB activation.	Superoxides	89-99	interleukin 1 beta	Homo sapiens	57-65
16636588-8	2006	Intracellular calcium was increased by TNF-alpha and IL-1beta.	Calcium	14-21	interleukin 1 beta	Homo sapiens	53-61
16636588-10	2006	Silymarin dose-dependently inhibited the TNF-alpha- or IL-1beta-induced NF-kappaB activation and MCP-1 expression.	Silymarin	0-9	interleukin 1 beta	Homo sapiens	55-63
16636588-12	2006	CONCLUSIONS: Induction of NF-kappaB within 30 min by TNF-alpha- and IL-1beta was mediated through intracellular calcium but not ROS.	Calcium	112-119	interleukin 1 beta	Homo sapiens	68-76
16391493-1	2006	PURPOSE: The aims of this study were to examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin 1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha).	Berberine	63-72	interleukin 1 beta	Homo sapiens	274-291
16775385-8	2006	Most importantly, administration of the COX-2 inhibitor NS-398 attenuated Tat-mediated upregulation of mRNA and protein expression of inflammatory mediators, such as monocyte chemoattractant protein-1, interleukin-1beta, tumor necrosis factor-alpha, and inducible nitric oxide synthase.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	56-62	interleukin 1 beta	Homo sapiens	202-248
16343789-6	2006	Lipoteichoic acid-activated glial cells produced nitric oxide and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta) that contributed to lipoteichoic acid-induced blood-brain barrier disruption, since the direct treatment of the endothelial monolayer with tumor necrosis factor-alpha or interleukin-1beta increased blood-brain barrier permeability, whereas the pre-treatment of lipoteichoic acid-activated glial cells with antibodies against these two cytokines blocked lipoteichoic acid effects.	lipoteichoic acid	0-17	interleukin 1 beta	Homo sapiens	126-143
16343789-6	2006	Lipoteichoic acid-activated glial cells produced nitric oxide and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta) that contributed to lipoteichoic acid-induced blood-brain barrier disruption, since the direct treatment of the endothelial monolayer with tumor necrosis factor-alpha or interleukin-1beta increased blood-brain barrier permeability, whereas the pre-treatment of lipoteichoic acid-activated glial cells with antibodies against these two cytokines blocked lipoteichoic acid effects.	lipoteichoic acid	0-17	interleukin 1 beta	Homo sapiens	315-332
16343789-6	2006	Lipoteichoic acid-activated glial cells produced nitric oxide and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta) that contributed to lipoteichoic acid-induced blood-brain barrier disruption, since the direct treatment of the endothelial monolayer with tumor necrosis factor-alpha or interleukin-1beta increased blood-brain barrier permeability, whereas the pre-treatment of lipoteichoic acid-activated glial cells with antibodies against these two cytokines blocked lipoteichoic acid effects.	Nitric Oxide	49-61	interleukin 1 beta	Homo sapiens	315-332
16343789-6	2006	Lipoteichoic acid-activated glial cells produced nitric oxide and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta) that contributed to lipoteichoic acid-induced blood-brain barrier disruption, since the direct treatment of the endothelial monolayer with tumor necrosis factor-alpha or interleukin-1beta increased blood-brain barrier permeability, whereas the pre-treatment of lipoteichoic acid-activated glial cells with antibodies against these two cytokines blocked lipoteichoic acid effects.	lipoteichoic acid	165-182	interleukin 1 beta	Homo sapiens	126-143
16343789-6	2006	Lipoteichoic acid-activated glial cells produced nitric oxide and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta) that contributed to lipoteichoic acid-induced blood-brain barrier disruption, since the direct treatment of the endothelial monolayer with tumor necrosis factor-alpha or interleukin-1beta increased blood-brain barrier permeability, whereas the pre-treatment of lipoteichoic acid-activated glial cells with antibodies against these two cytokines blocked lipoteichoic acid effects.	lipoteichoic acid	165-182	interleukin 1 beta	Homo sapiens	315-332
16391493-1	2006	PURPOSE: The aims of this study were to examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin 1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha).	Berberine	63-72	interleukin 1 beta	Homo sapiens	293-301
16391493-7	2006	CONCLUSION: These findings indicate that berberine dose-dependently inhibited the expression of IL-8 and MCP-1 induced by IL-1beta or TNF-alpha.	Berberine	41-50	interleukin 1 beta	Homo sapiens	122-130
16497254-8	2006	CONCLUSIONS: Our results suggest that DHA administered in the acute phase of infection could modulate IL-1 and TNF production, and secondarily, decrease the effect of infection on appetite.	Docosahexaenoic Acids	38-41	interleukin 1 beta	Homo sapiens	102-114
16423197-5	2006	SB203580 and H-7, but not PD098059, inhibited IL-1beta-induced expression of COX-2 protein.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	46-54
16613100-5	2006	RESULTS: At early stages and height of CAP exacerbation, concentrations of IL-1beta, IL-6, IL-8, TNF-gamma and TNFalpha were elevated (951.1 +/- 104.2 pg/ml; 172.8 +/- 24.3 pg/ml; 432.6 +/- 68.5 pg/ml; 823.3 +/- 97.5 pg/ml; 158.7 +/- 19.6 pg/ml, respectively).	cap	39-42	interleukin 1 beta	Homo sapiens	75-83
16005497-5	2006	RESULTS: We found that IL-1beta and IL-6 levels were significantly increased in the coronary sinus of patients receiving either bare, paclitaxel- or sirolimus-eluting stents 20 min after stent implantation as compared with basal concentrations.	Paclitaxel	134-144	interleukin 1 beta	Homo sapiens	23-31
16005497-5	2006	RESULTS: We found that IL-1beta and IL-6 levels were significantly increased in the coronary sinus of patients receiving either bare, paclitaxel- or sirolimus-eluting stents 20 min after stent implantation as compared with basal concentrations.	Sirolimus	149-158	interleukin 1 beta	Homo sapiens	23-31
16626550-0	2006	[Upregulated Rho-kinase and increased phosphorylation of myosin-binding subunit of myosin phosphates are key players in a porcine coronary artery spasm model with interleukin-1beta].	myosin phosphates	83-100	interleukin 1 beta	Homo sapiens	163-180
16626550-7	2006	RESULTS: Intracoronary serotonin or histamine repeatedly induced coronary artery spasm and coronary arterial stenosis was evidenced at IL-1beta-treated site.	Serotonin	23-32	interleukin 1 beta	Homo sapiens	135-143
16626550-7	2006	RESULTS: Intracoronary serotonin or histamine repeatedly induced coronary artery spasm and coronary arterial stenosis was evidenced at IL-1beta-treated site.	Histamine	36-45	interleukin 1 beta	Homo sapiens	135-143
16377203-8	2005	Additionally, continuous supplement of IL-1beta in the CB-MSCs culture will facilitate adipogenic maturation of CB-MSCs as evidenced by the presence of oil drops in the CB-MSCs and secretion of leptin, a molecule marker of adipocytes.	Oils	152-155	interleukin 1 beta	Homo sapiens	39-47
16325157-4	2005	In microglia stimulated with LPS and IFN-gamma, nicergoline suppressed the production of superoxide anions, interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in a dose-dependent manner.	Nicergoline	48-59	interleukin 1 beta	Homo sapiens	108-130
16226404-0	2005	Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts.	Dinoprostone	89-93	interleukin 1 beta	Homo sapiens	43-51
16207716-7	2005	Finally, H2O2-oxidized rhTrx-1 reduced IL-1beta mRNA synthesis in lipopolysaccharide-activated HMDM.	Hydrogen Peroxide	9-13	interleukin 1 beta	Homo sapiens	39-47
16226404-7	2005	In the absence of stretching, it was found that 10 pM of IL-1beta markedly induced higher levels of COX-2, MMP-1 gene expression, and PGE2 production than non-treated cells.	Dinoprostone	134-138	interleukin 1 beta	Homo sapiens	57-65
16226404-8	2005	Furthermore, cells with 4% stretching decreased the COX-2 and MMP-1 gene expression and PGE2 production that were stimulated by IL-1beta, whereas cells with 8% stretching further increased these gene products and/or expression levels in addition to the effects of IL-1beta stimulation.	Dinoprostone	88-92	interleukin 1 beta	Homo sapiens	128-136
16359550-13	2005	IL-1beta-induced MMP-12 activity and gene expression was down-regulated by the corticosteroid dexamethasone but up-regulated by the inflammatory cytokine tumour necrosis factor (TNF)-alpha through enhancing activator protein-1 activation by IL-1beta.	Dexamethasone	94-107	interleukin 1 beta	Homo sapiens	0-8
15953673-0	2005	Interleukin-1beta (IL-1beta) induces a crosstalk between cAMP and ceramide signaling pathways in thyroid epithelial cells.	Cyclic AMP	57-61	interleukin 1 beta	Homo sapiens	0-17
15953673-0	2005	Interleukin-1beta (IL-1beta) induces a crosstalk between cAMP and ceramide signaling pathways in thyroid epithelial cells.	Cyclic AMP	57-61	interleukin 1 beta	Homo sapiens	19-27
15953673-0	2005	Interleukin-1beta (IL-1beta) induces a crosstalk between cAMP and ceramide signaling pathways in thyroid epithelial cells.	Ceramides	66-74	interleukin 1 beta	Homo sapiens	0-17
15953673-0	2005	Interleukin-1beta (IL-1beta) induces a crosstalk between cAMP and ceramide signaling pathways in thyroid epithelial cells.	Ceramides	66-74	interleukin 1 beta	Homo sapiens	19-27
15953673-4	2005	Moreover, IL-1beta and ceramides are demonstrated to inhibit the TSH-induced cAMP production via the implication of alphaGi subunit of the adenylyl cyclase system.	Thyrotropin	65-68	interleukin 1 beta	Homo sapiens	10-18
15953673-4	2005	Moreover, IL-1beta and ceramides are demonstrated to inhibit the TSH-induced cAMP production via the implication of alphaGi subunit of the adenylyl cyclase system.	Cyclic AMP	77-81	interleukin 1 beta	Homo sapiens	10-18
17305518-6	2005	Reactive oxygen species can increase gene expression of many inflammatory mediators, such as IL-1 and TNFalpha from macrophages, alveolar and bronchial epithelial cells.	Reactive Oxygen Species	0-23	interleukin 1 beta	Homo sapiens	93-97
16159934-7	2005	EMSAs showed that sulindac dramatically decreased NF-kappaB activation and diminished TNFalpha and IL-1beta-induced NF-kappaB DNA binding activity.	Sulindac	18-26	interleukin 1 beta	Homo sapiens	99-107
16306769-8	2005	Moreover, tumor necrosis factor-alpha- or interleukin-1beta-induced CCL20 secretion was greatly diminished by 5-aminosalicylic acid and/or glucocorticoid treatment of human intestinal epithelial HT-29 cells.	Mesalamine	110-131	interleukin 1 beta	Homo sapiens	42-59
16123165-1	2005	In testicular Sertoli cells, IL-1beta regulates steroid, lactate, and transferrin secretion; although each influences germ cell development and spermatogenesis, little is known about the signaling mechanisms involved.	Steroids	48-55	interleukin 1 beta	Homo sapiens	29-37
16123165-1	2005	In testicular Sertoli cells, IL-1beta regulates steroid, lactate, and transferrin secretion; although each influences germ cell development and spermatogenesis, little is known about the signaling mechanisms involved.	Lactic Acid	57-64	interleukin 1 beta	Homo sapiens	29-37
16123165-2	2005	In other cell types, IL-1beta potently induces reactive oxygen species and/or cyclooxygenase-2 (COX-2).	Reactive Oxygen Species	47-70	interleukin 1 beta	Homo sapiens	21-29
16274887-3	2005	When macrophages were incubated in sulfur amino acid-deprived medium, lipopolysaccharide induction of iNOS, TNFalpha, IL-1beta, and IL-6 was significantly decreased compared to control.	Amino Acids, Sulfur	35-52	interleukin 1 beta	Homo sapiens	118-126
16299325-7	2005	These findings are consistent with in vitro results showing that production of IL-1beta and IL-6 mRNA and IL-6 protein by human macrophages exposed to mannose-bearing Klebsiella O serotypes is significantly increased by SP-D.	Mannose	151-158	interleukin 1 beta	Homo sapiens	79-87
17086498-4	2005	Thus, we investigated the effect of oxysterols, including 25-hydroxycholesterol and 7beta-hydroxycholesterol, on IL-1beta-induced IL-8 production in Caco-2 cells (a human colon carcinoma cell line).	Oxysterols	36-46	interleukin 1 beta	Homo sapiens	113-121
17086498-4	2005	Thus, we investigated the effect of oxysterols, including 25-hydroxycholesterol and 7beta-hydroxycholesterol, on IL-1beta-induced IL-8 production in Caco-2 cells (a human colon carcinoma cell line).	25-hydroxycholesterol	58-79	interleukin 1 beta	Homo sapiens	113-121
17086498-4	2005	Thus, we investigated the effect of oxysterols, including 25-hydroxycholesterol and 7beta-hydroxycholesterol, on IL-1beta-induced IL-8 production in Caco-2 cells (a human colon carcinoma cell line).	cholest-5-en-3 beta,7 alpha-diol	84-108	interleukin 1 beta	Homo sapiens	113-121
17086498-5	2005	Pre-treatment of Caco-2 cells with 25-hydroxycholesterol significantly enhanced IL-1beta-induced IL-8 expression at both mRNA and protein levels.	25-hydroxycholesterol	35-56	interleukin 1 beta	Homo sapiens	80-88
17086498-7	2005	Furthermore, pre-treatment with 25-hydroxycholesterol, followed by IL-1beta stimulation, enhanced IL-8 promoter activity beyond that observed with IL-1beta alone.	25-hydroxycholesterol	32-53	interleukin 1 beta	Homo sapiens	147-155
17086498-8	2005	These results suggest that 25-hydroxycholesterol enhances IL-1beta-induced IL-8 production, possibly by enhancing promoter activity.	25-hydroxycholesterol	27-48	interleukin 1 beta	Homo sapiens	58-66
16159934-9	2005	The addition of sulindac to IL-1beta- and TNFalpha-treated endometriotic stromal cells also resulted in a 4-fold inhibition of RANTES protein secretion (P &lt; 0.05).	Sulindac	16-24	interleukin 1 beta	Homo sapiens	28-36
16272305-0	2005	IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cells.	Estradiol	61-70	interleukin 1 beta	Homo sapiens	0-8
16354411-5	2005	Furthermore, licochalcone A and NS-398 suppressed PGF(2alpha) production by IL-1beta.	Prostaglandins F	50-53	interleukin 1 beta	Homo sapiens	76-84
16354411-10	2005	Furthermore, it appears that the inhibitory effect of licochalcone A on PGE2 production in response to IL-1beta is quite different from that of the steroid.	licochalcone A	54-68	interleukin 1 beta	Homo sapiens	103-111
16354411-10	2005	Furthermore, it appears that the inhibitory effect of licochalcone A on PGE2 production in response to IL-1beta is quite different from that of the steroid.	Dinoprostone	72-76	interleukin 1 beta	Homo sapiens	103-111
16494031-4	2005	RESULT: Compared with the control group, the levels of EGF, TGF-alpha, IL-1beta, IL-6 and IL-8 were significantly increased by treatment with Aloe coarse polysaccharide (P &lt; 0.05, P &lt; 0.01) and in a dose dependent manner, and the levels of TGF-beta1 and TNF were also increased but no statistical significance.	Polysaccharides	154-168	interleukin 1 beta	Homo sapiens	71-79
16494031-5	2005	CONCLUSION: Aloe coarse polysaccharide may promote keratinocytes to secrete EGF, TGF-alpha, IL-1beta, IL-6 and IL-8.	Polysaccharides	24-38	interleukin 1 beta	Homo sapiens	92-100
16272352-6	2005	PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK.	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	18-26
16354411-0	2005	Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts.	licochalcone A	14-28	interleukin 1 beta	Homo sapiens	81-89
16354411-0	2005	Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts.	Flavonoids	38-47	interleukin 1 beta	Homo sapiens	81-89
16354411-0	2005	Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts.	Dinoprostone	98-102	interleukin 1 beta	Homo sapiens	81-89
16354411-2	2005	In this study, we examined the effect of licochalcone A on the production of chemical mediators such as prostaglandin (PG)E2 and cytokines by interleukin (IL)-1beta in human skin fibroblasts.	licochalcone A	41-55	interleukin 1 beta	Homo sapiens	142-164
16354411-2	2005	In this study, we examined the effect of licochalcone A on the production of chemical mediators such as prostaglandin (PG)E2 and cytokines by interleukin (IL)-1beta in human skin fibroblasts.	Dinoprostone	104-124	interleukin 1 beta	Homo sapiens	142-164
16354411-3	2005	Licochalcone A (IC50 15.0 nM) inhibited PGE2 production, but not IL-6 and IL-8 production, in response to IL-1beta.	licochalcone A	0-14	interleukin 1 beta	Homo sapiens	106-114
16354411-3	2005	Licochalcone A (IC50 15.0 nM) inhibited PGE2 production, but not IL-6 and IL-8 production, in response to IL-1beta.	Dinoprostone	40-44	interleukin 1 beta	Homo sapiens	106-114
16354411-5	2005	Furthermore, licochalcone A and NS-398 suppressed PGF(2alpha) production by IL-1beta.	licochalcone A	13-27	interleukin 1 beta	Homo sapiens	76-84
16354411-5	2005	Furthermore, licochalcone A and NS-398 suppressed PGF(2alpha) production by IL-1beta.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	32-38	interleukin 1 beta	Homo sapiens	76-84
16148020-2	2005	We reported previously that the fluoroquinolone ciprofloxacin potentiated interleukin (IL)-1beta-stimulated expression of matrix metalloproteinases (MMP)-3 and MMP-1 in human tendon-derived cells.	Fluoroquinolones	32-47	interleukin 1 beta	Homo sapiens	74-96
16148020-2	2005	We reported previously that the fluoroquinolone ciprofloxacin potentiated interleukin (IL)-1beta-stimulated expression of matrix metalloproteinases (MMP)-3 and MMP-1 in human tendon-derived cells.	Ciprofloxacin	48-61	interleukin 1 beta	Homo sapiens	74-96
16148020-9	2005	In contrast, ciprofloxacin and norfloxacin increased basal and IL-1beta-stimulated MMP-1 mRNA expression.	Ciprofloxacin	13-26	interleukin 1 beta	Homo sapiens	63-71
16148020-9	2005	In contrast, ciprofloxacin and norfloxacin increased basal and IL-1beta-stimulated MMP-1 mRNA expression.	Norfloxacin	31-42	interleukin 1 beta	Homo sapiens	63-71
16148020-10	2005	Both the inhibition of MMP-13 and the potentiation of MMP-1 expression by fluoroquinolones were accompanied by corresponding changes in IL-1beta-stimulated MMP output.	Fluoroquinolones	74-90	interleukin 1 beta	Homo sapiens	136-144
16154157-1	2005	We examined the role of prostaglandin D(2) (PGD(2)) in the expression of vascular cell adhesion molecule-1 (VCAM)-1 following interleukin-1beta (IL-1) stimulation in human umbilical vein endothelial cells (HUVEC) transfected with lipocaline-type PGD(2) synthase (L-PGDS) genes.	Prostaglandins D	24-39	interleukin 1 beta	Homo sapiens	126-143
16154157-1	2005	We examined the role of prostaglandin D(2) (PGD(2)) in the expression of vascular cell adhesion molecule-1 (VCAM)-1 following interleukin-1beta (IL-1) stimulation in human umbilical vein endothelial cells (HUVEC) transfected with lipocaline-type PGD(2) synthase (L-PGDS) genes.	Prostaglandins D	24-39	interleukin 1 beta	Homo sapiens	145-149
16212939-5	2005	In contrast, the mutant containing an additional N-glycosylation site on the N-terminal 24 amino acids of hIL-1beta (Gln15Asn) secreted twice as much rhG-CSF into culture media as wild type hIL-1beta.	Nitrogen	49-50	interleukin 1 beta	Homo sapiens	106-115
16272305-3	2005	Estradiol inhibited the IL-1beta-mediated mRNA expression and secretion of human beta-defensin-2 and CXCL8 by uterine epithelial cells while progesterone had no effect.	Estradiol	0-9	interleukin 1 beta	Homo sapiens	24-32
16272305-3	2005	Estradiol inhibited the IL-1beta-mediated mRNA expression and secretion of human beta-defensin-2 and CXCL8 by uterine epithelial cells while progesterone had no effect.	Progesterone	141-153	interleukin 1 beta	Homo sapiens	24-32
16272305-4	2005	Inhibition of the IL-1beta-mediated response by estradiol was dose dependent, with maximal inhibition observed using 10(-7) to 10(-10) M, and was shown to be mediated through the estrogen receptor because addition of a pure estrogen receptor antagonist abrogated this effect.	Estradiol	48-57	interleukin 1 beta	Homo sapiens	18-26
16272305-5	2005	The mechanism by which estradiol inhibits IL-1beta-mediated responses by uterine epithelial cells appears to be the down-modulation of the IL-1R type I, thereby reducing the uterine epithelial cell"s ability to respond to IL-1beta.	Estradiol	23-32	interleukin 1 beta	Homo sapiens	42-50
16272305-5	2005	The mechanism by which estradiol inhibits IL-1beta-mediated responses by uterine epithelial cells appears to be the down-modulation of the IL-1R type I, thereby reducing the uterine epithelial cell"s ability to respond to IL-1beta.	Estradiol	23-32	interleukin 1 beta	Homo sapiens	222-230
16272305-6	2005	These results suggest that the inhibitory effect of estradiol on IL-1beta-mediated inflammatory responses by uterine epithelial cells indicates a link between the endocrine and immune systems and may be crucial for dampening proinflammatory responses during the time of ovulation or pregnancy.	Estradiol	52-61	interleukin 1 beta	Homo sapiens	65-73
16225487-11	2005	These data indicate the need for a large investigation to extend the present findings, and suggest that butyrate may exert its action through downregulation of NF-kappaB and IL-1beta.	Butyrates	104-112	interleukin 1 beta	Homo sapiens	174-182
16260731-3	2005	IL-32 synergized with the NOD1- and NOD2-specific muropeptides of peptidoglycans for the release of IL-1beta and IL-6 (a 3- to 10-fold increase).	muropeptides	50-62	interleukin 1 beta	Homo sapiens	100-108
16216268-1	2005	The human cytokine interleukin-1beta (IL-1beta) interacts with the interleukin type I receptor using two large docking surfaces designated A and B. Crystallographic studies reveal that a single histidine residue (His30) in IL-1beta makes critical electrostatic interactions at the receptor/ligand interface.	Histidine	194-203	interleukin 1 beta	Homo sapiens	19-36
16216268-1	2005	The human cytokine interleukin-1beta (IL-1beta) interacts with the interleukin type I receptor using two large docking surfaces designated A and B. Crystallographic studies reveal that a single histidine residue (His30) in IL-1beta makes critical electrostatic interactions at the receptor/ligand interface.	Histidine	194-203	interleukin 1 beta	Homo sapiens	38-46
16216268-1	2005	The human cytokine interleukin-1beta (IL-1beta) interacts with the interleukin type I receptor using two large docking surfaces designated A and B. Crystallographic studies reveal that a single histidine residue (His30) in IL-1beta makes critical electrostatic interactions at the receptor/ligand interface.	Histidine	194-203	interleukin 1 beta	Homo sapiens	223-231
16216268-6	2005	A comparison of native solvent exchange in wild-type and mutated IL-1beta shows transmission of local destabilization along the hydrogen bond network of the beta-sheet.	Hydrogen	128-136	interleukin 1 beta	Homo sapiens	65-73
16037543-9	2005	Exposure of the mucosa to HCl caused IL-1beta to increase only in the mucosa and not in the supernatant.	Hydrochloric Acid	26-29	interleukin 1 beta	Homo sapiens	37-45
16037543-10	2005	These data suggest that HCl-induced damage occurs first in the mucosa, leading to the production of IL-1beta and IL-6 but not H2O2.	Hydrochloric Acid	24-27	interleukin 1 beta	Homo sapiens	100-108
16212625-7	2005	IL1-beta stimulated IL-8 production was significantly increased in rapidly growing hTBEC cultures (n = 8) treated with cyclosporin (p = 0.049).	Cyclosporine	119-130	interleukin 1 beta	Homo sapiens	0-8
16320828-4	2005	To test the hypothesis that curcumin also protects chondrocytes from morphological alterations induced by IL-1beta, we investigated its in vitro effects on apoptotic signalling proteins and key cartilage-specific matrix components in IL-1beta-stimulated chondrocytes.	Curcumin	28-36	interleukin 1 beta	Homo sapiens	106-114
16320828-8	2005	Transmission electron microscopy of chondrocytes stimulated with IL-1beta revealed early degenerative changes which were relieved by curcumin co-treatment.	Curcumin	133-141	interleukin 1 beta	Homo sapiens	65-73
16320828-9	2005	The suppression of collagen type II and beta1-integrin synthesis by IL-1beta was inhibited by curcumin.	Curcumin	94-102	interleukin 1 beta	Homo sapiens	68-76
16320828-10	2005	Additionally, curcumin antagonized IL-1beta-induced caspase-3 activation in a time-dependent manner.	Curcumin	14-22	interleukin 1 beta	Homo sapiens	35-43
16320828-11	2005	This study clearly demonstrates that curcumin exerts anti-apoptotic and anti-catabolic effects on IL-1beta-stimulated articular chondrocytes.	Curcumin	37-45	interleukin 1 beta	Homo sapiens	98-106
16249517-9	2005	Moreover, DHA(22:6n3) diminished IL-1beta induced phosphorylation of the inhibitor of nuclear factor (NF)-kappaB (I-kappaBalpha), thus preventing its degradation.	dehydroacetic acid	10-13	interleukin 1 beta	Homo sapiens	33-41
16249450-2	2005	It has been recently suggested that high glucose-induced beta-cell apoptosis in type 2 diabetes shares a final common pathway with type 1 diabetes, involving interleukin-1beta (IL-1beta) production by beta-cells, nuclear factor-kappaB (NF-kappaB) activation, and death via Fas-FasL.	Glucose	41-48	interleukin 1 beta	Homo sapiens	158-175
16249450-2	2005	It has been recently suggested that high glucose-induced beta-cell apoptosis in type 2 diabetes shares a final common pathway with type 1 diabetes, involving interleukin-1beta (IL-1beta) production by beta-cells, nuclear factor-kappaB (NF-kappaB) activation, and death via Fas-FasL.	Glucose	41-48	interleukin 1 beta	Homo sapiens	177-185
16249450-3	2005	The aim of this study was to test whether human islet exposure to high glucose in vitro, or to the type 2 diabetes environment in vivo, induces IL-1beta expression and consequent activation of NF-kappaB-dependent genes.	Glucose	71-78	interleukin 1 beta	Homo sapiens	144-152
16081677-0	2005	Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	20-37
16081677-3	2005	In this study and other reports, curcumin suppresses interleukin-1beta-induced formation of prostaglandin E(2) in a concentration-dependent manner.	Curcumin	33-41	interleukin 1 beta	Homo sapiens	53-70
16081677-3	2005	In this study and other reports, curcumin suppresses interleukin-1beta-induced formation of prostaglandin E(2) in a concentration-dependent manner.	Dinoprostone	92-110	interleukin 1 beta	Homo sapiens	53-70
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	114-122	interleukin 1 beta	Homo sapiens	0-17
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	248-256	interleukin 1 beta	Homo sapiens	0-17
16081677-12	2005	These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2.	Curcumin	28-36	interleukin 1 beta	Homo sapiens	46-54
16081677-12	2005	These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2.	Prostaglandins E	63-66	interleukin 1 beta	Homo sapiens	46-54
16051245-7	2005	The glycoprotein, plerocercoid-immunosuppressive factor, from crude ES products could suppress the gene expression of TNF-alpha, IL-1beta and NO synthesis in LPS-stimulated RAW264.7 macrophages.	Einsteinium	68-70	interleukin 1 beta	Homo sapiens	129-137
16106045-0	2005	Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes.	Ceramides	0-8	interleukin 1 beta	Homo sapiens	92-109
16106045-3	2005	Activation of sphingomyelinase (SMase) and the subsequent generation of ceramide are early steps in the IL-1beta signaling cascade.	Ceramides	72-80	interleukin 1 beta	Homo sapiens	104-112
16106045-4	2005	In this study, we investigate the role of ceramide in the IL-1beta regulation of C/EBP in primary hepatocytes.	Ceramides	42-50	interleukin 1 beta	Homo sapiens	58-66
16106045-11	2005	These results suggest that ceramide and ERK mediate a pathway in the IL-1beta signaling cascade, which results in rapid posttranslational activation of C/EBPbeta.	Ceramides	27-35	interleukin 1 beta	Homo sapiens	69-77
16393772-3	2005	RESULTS: Aurothiomalate, hydroxychloroquine, methotrexate and leflunomide inhibited IL-1beta-induced inducible NO synthase (iNOS) expression and NO production in immortalized H4 chondrocytes, while penicillamine and sulfasalazine had no effect.	Gold Sodium Thiomalate	9-23	interleukin 1 beta	Homo sapiens	84-92
16061772-5	2005	Furthermore, we show for the first time that cigarette smoke synergizes with proinflammatory cytokines IL-1beta and tumor necrosis factor-alpha, and it is this interaction that confers steroid resistance to smoke-induced CXCL8 release.	Steroids	185-192	interleukin 1 beta	Homo sapiens	103-143
16264101-10	2005	Novel functions regulated by IL-1beta in endometrium, including genes involved in free radical protection, and fatty acid metabolism were also identified.	Fatty Acids	111-121	interleukin 1 beta	Homo sapiens	29-37
16393772-3	2005	RESULTS: Aurothiomalate, hydroxychloroquine, methotrexate and leflunomide inhibited IL-1beta-induced inducible NO synthase (iNOS) expression and NO production in immortalized H4 chondrocytes, while penicillamine and sulfasalazine had no effect.	Hydroxychloroquine	25-43	interleukin 1 beta	Homo sapiens	84-92
16393772-3	2005	RESULTS: Aurothiomalate, hydroxychloroquine, methotrexate and leflunomide inhibited IL-1beta-induced inducible NO synthase (iNOS) expression and NO production in immortalized H4 chondrocytes, while penicillamine and sulfasalazine had no effect.	Methotrexate	45-57	interleukin 1 beta	Homo sapiens	84-92
16393772-3	2005	RESULTS: Aurothiomalate, hydroxychloroquine, methotrexate and leflunomide inhibited IL-1beta-induced inducible NO synthase (iNOS) expression and NO production in immortalized H4 chondrocytes, while penicillamine and sulfasalazine had no effect.	Leflunomide	62-73	interleukin 1 beta	Homo sapiens	84-92
16393772-3	2005	RESULTS: Aurothiomalate, hydroxychloroquine, methotrexate and leflunomide inhibited IL-1beta-induced inducible NO synthase (iNOS) expression and NO production in immortalized H4 chondrocytes, while penicillamine and sulfasalazine had no effect.	Penicillamine	198-211	interleukin 1 beta	Homo sapiens	84-92
16393772-3	2005	RESULTS: Aurothiomalate, hydroxychloroquine, methotrexate and leflunomide inhibited IL-1beta-induced inducible NO synthase (iNOS) expression and NO production in immortalized H4 chondrocytes, while penicillamine and sulfasalazine had no effect.	Sulfasalazine	216-229	interleukin 1 beta	Homo sapiens	84-92
16393772-5	2005	Aurothiomalate and hydroxychloroquine also inhibited IL-1beta-induced NO production in OA cartilage whereas methotrexate and leflunomide had no effect.	Gold Sodium Thiomalate	0-14	interleukin 1 beta	Homo sapiens	53-61
16393772-5	2005	Aurothiomalate and hydroxychloroquine also inhibited IL-1beta-induced NO production in OA cartilage whereas methotrexate and leflunomide had no effect.	Hydroxychloroquine	19-37	interleukin 1 beta	Homo sapiens	53-61
16393772-6	2005	CONCLUSION: Aurothiomalate and hydroxychloroquine suppressed IL-1beta-induced NO production in chondrocyte cultures and in OA cartilage.	Hydroxychloroquine	31-49	interleukin 1 beta	Homo sapiens	61-69
15982670-0	2005	Myricetin inhibits the induction of anti-Fas IgM-, tumor necrosis factor-alpha- and interleukin-1beta-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63.	myricetin	0-9	interleukin 1 beta	Homo sapiens	84-101
16363279-7	2005	Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6.	Iloprost	13-21	interleukin 1 beta	Homo sapiens	46-54
16251433-8	2005	In addition, the frequency of mEPSCs was enhanced in neurons pretreated with interleukin-1beta or lipopolysaccharide, which elevated expression of COX-2 and mPGES-1 and produced PGE2, and this enhancement was inhibited by a COX-2 inhibitor that inhibited production of PGE2.	Dinoprostone	178-182	interleukin 1 beta	Homo sapiens	77-94
16251433-8	2005	In addition, the frequency of mEPSCs was enhanced in neurons pretreated with interleukin-1beta or lipopolysaccharide, which elevated expression of COX-2 and mPGES-1 and produced PGE2, and this enhancement was inhibited by a COX-2 inhibitor that inhibited production of PGE2.	Dinoprostone	269-273	interleukin 1 beta	Homo sapiens	77-94
16243232-8	2005	When they were pre-incubated with IL-1beta, IL-6 or OSM, N osteoblasts inhibited AGG synthesis and increased MMP-3 and -13 gene expression by chondrocytes in alginate beads in a same order of magnitude as SC osteoblasts.	Alginates	158-166	interleukin 1 beta	Homo sapiens	34-42
16169525-4	2005	In addition, LA, ALA, and DHA decreased IL-6, IL-1beta, and TNFalpha gene expression (P &lt; 0.05 for all) and nuclear factor (NF)-kappaB DNA-binding activity, whereas peroxisome proliferator-activated receptor-gamma (PPARgamma) DNA-binding activity was increased.	alpha-Linolenic Acid	17-20	interleukin 1 beta	Homo sapiens	46-54
16169525-4	2005	In addition, LA, ALA, and DHA decreased IL-6, IL-1beta, and TNFalpha gene expression (P &lt; 0.05 for all) and nuclear factor (NF)-kappaB DNA-binding activity, whereas peroxisome proliferator-activated receptor-gamma (PPARgamma) DNA-binding activity was increased.	Docosahexaenoic Acids	26-29	interleukin 1 beta	Homo sapiens	46-54
15982670-6	2005	Treatment of MG-63 cells with myricetin not only inhibited anti-Fas IgM-induced apoptosis, but also blocked the synergetic effect of anti-Fas IgM with TNF-alpha or IL-1beta on cell death.	myricetin	30-39	interleukin 1 beta	Homo sapiens	164-172
15982670-7	2005	The apoptotic inhibition of myricetin is associated with inhibition of TNF-alpha and IL-1beta-mediated Fas expression and enhancement of FLIP expression, resulting in a decrease of caspase-8 and caspase-3 activation.	myricetin	28-37	interleukin 1 beta	Homo sapiens	85-93
16079150-6	2005	Peroxynitrite also inhibited NF-kappaB in two human endothelial cell lines activated with tumor necrosis factor-alpha or interleukin-1beta.	Peroxynitrous Acid	0-13	interleukin 1 beta	Homo sapiens	121-138
15888346-10	2005	R-130823 did not affect the production of PGE(2) in spheroid culture, while the addition of R-130823 suppressed IL-1beta-induced PGE(2) synthesis in monolayer culture of SW 982 cells.	Prostaglandins E	129-132	interleukin 1 beta	Homo sapiens	112-120
15908470-5	2005	In addition, EtOH significantly reduced NF-kappaB and AP-1 binding activity induced by IL-1beta and inhibited MCP-1 gene transcription.	Ethanol	13-17	interleukin 1 beta	Homo sapiens	87-95
15908470-0	2005	Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1{beta}-activated human endothelial cells.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	62-80
16273626-4	2005	Inflammatory control group and ciglitazone group were treated with 5 microg/L of human interleukin-1beta (hIL-1beta) to make inflammatory model of HGBECs.	ciglitazone	31-42	interleukin 1 beta	Homo sapiens	87-104
16273626-4	2005	Inflammatory control group and ciglitazone group were treated with 5 microg/L of human interleukin-1beta (hIL-1beta) to make inflammatory model of HGBECs.	ciglitazone	31-42	interleukin 1 beta	Homo sapiens	106-115
16046125-0	2005	Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis.	diazocan	47-55	interleukin 1 beta	Homo sapiens	89-106
15941782-4	2005	In the present study, we demonstrated that preexposure of U937 macrophage-like cells to sodium lactate increased LPS-stimulated matrix metalloproteinase (MMP)-1, IL-1beta, and IL-6 secretion.	Sodium Lactate	88-102	interleukin 1 beta	Homo sapiens	162-170
15941782-8	2005	Results showed that blocking of either NF-kappaB or MAPK pathways led to the inhibition of MMP-1, IL-1beta, and IL-6 expression stimulated by sodium lactate, LPS, or both.	Sodium Lactate	142-156	interleukin 1 beta	Homo sapiens	98-106
16123330-1	2005	OBJECTIVE: The purpose of this study was to investigate the receptor requirements for enhanced IL-1beta-induced secretion of nitric oxide (NO) by endothelial cells (ECs) in the presence of fibrinogen.	Nitric Oxide	125-137	interleukin 1 beta	Homo sapiens	95-103
15908470-2	2005	IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells.	Ethanol	146-150	interleukin 1 beta	Homo sapiens	0-8
15908470-2	2005	IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells.	Ethanol	146-150	interleukin 1 beta	Homo sapiens	178-186
15908470-2	2005	IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells.	Ethanol	307-311	interleukin 1 beta	Homo sapiens	0-8
15908470-2	2005	IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells.	Ethanol	307-311	interleukin 1 beta	Homo sapiens	178-186
15908470-3	2005	Similarly, EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 mRNA expression.	Ethanol	11-15	interleukin 1 beta	Homo sapiens	43-51
16046125-2	2005	This versatile 8-membered ring containing scaffold possesses an N-5 ring nitrogen that was used to explore structure-activity relationships in a cell-based assay measuring inhibition of interleukin-1beta.	Nitrogen	73-81	interleukin 1 beta	Homo sapiens	186-203
16210060-2	2005	Increased IL-1 immunostaining in the submucosa of patients with toluene diisocyanate (TDI)-induced asthma has also been observed, suggesting that this cytokine might also be important in asthma associated with low-molecular-weight chemicals.	Toluene 2,4-Diisocyanate	64-84	interleukin 1 beta	Homo sapiens	10-14
16051523-1	2005	The in vitro effect of the hydrophilic statin - pravastatin - and three hydrophobic statins - atorvastatin, lovastatin and simvastatin - on the production of IL-1beta, IL-1ra, IL-2, IL-6 and IFN-gamma by human peripheral blood mononuclear cells (PBMC) and their response to mitogens was examined.	Atorvastatin	94-106	interleukin 1 beta	Homo sapiens	158-166
16051523-1	2005	The in vitro effect of the hydrophilic statin - pravastatin - and three hydrophobic statins - atorvastatin, lovastatin and simvastatin - on the production of IL-1beta, IL-1ra, IL-2, IL-6 and IFN-gamma by human peripheral blood mononuclear cells (PBMC) and their response to mitogens was examined.	Simvastatin	123-134	interleukin 1 beta	Homo sapiens	158-166
16051523-2	2005	Lovastatin and simvastatin increased the production of IL-1beta in a dose dependent manner and reduced secretion of IL-1ra at high concentration.	Lovastatin	0-10	interleukin 1 beta	Homo sapiens	55-63
16051523-2	2005	Lovastatin and simvastatin increased the production of IL-1beta in a dose dependent manner and reduced secretion of IL-1ra at high concentration.	Simvastatin	15-26	interleukin 1 beta	Homo sapiens	55-63
16283110-2	2005	IL-1 and TNFalpha enhance nitric oxide (NO) production in OA cartilage through the inducible nitric oxide synthase (iNOS) pathway and NO mediates many of the destructive effects of these cytokines.	Nitric Oxide	26-38	interleukin 1 beta	Homo sapiens	0-4
16283110-4	2005	RESULTS: IL-1 induced NO production in chondrocytes through nuclear factor kappa B (NF-kappaB) sensitive and dexamethasone insensitive expression of iNOS.	Dexamethasone	109-122	interleukin 1 beta	Homo sapiens	9-13
16210060-2	2005	Increased IL-1 immunostaining in the submucosa of patients with toluene diisocyanate (TDI)-induced asthma has also been observed, suggesting that this cytokine might also be important in asthma associated with low-molecular-weight chemicals.	Toluene 2,4-Diisocyanate	86-89	interleukin 1 beta	Homo sapiens	10-14
16177117-0	2005	Zinc-mediated inhibition of cyclic nucleotide phosphodiesterase activity and expression suppresses TNF-alpha and IL-1 beta production in monocytes by elevation of guanosine 3",5"-cyclic monophosphate.	Cyclic GMP	163-199	interleukin 1 beta	Homo sapiens	113-122
16000389-7	2005	Freshly isolated monocytes responded to the PAR-2 AP ASKH 95 (2-furoyl-LIGKV-OH) with the generation of a calcium flux and production of interleukin (IL)-1beta, IL-6, and IL-8.	2-furoyl-leucyl-isoleucyl-glycyl-lysyl-valine	62-79	interleukin 1 beta	Homo sapiens	137-159
16177117-2	2005	We investigated the role of cyclic nucleotide signaling in zinc inhibition of LPS-induced TNF-alpha and IL-1beta release from primary human monocytes and the monocytic cell line Mono Mac1.	Nucleotides, Cyclic	28-45	interleukin 1 beta	Homo sapiens	104-112
16177117-9	2005	In conclusion, inhibition of PDE by zinc abrogates the LPS-induced release of TNF-alpha and IL-1beta by increasing intracellular cGMP levels.	Cyclic GMP	129-133	interleukin 1 beta	Homo sapiens	92-100
16206353-6	2005	RESULTS: Pretreatment with 0.5 microM Se-met prevented IL-1beta-induced MMP-1 and aggrecanase-1 expression, and reduced the cytokine inhibitory effect on type II collagen, aggrecan core protein, and TGF-beta receptor II (TGF-betaRII) mRNA levels.	Selenomethionine	38-44	interleukin 1 beta	Homo sapiens	55-63
16150112-1	2005	We evaluated the presence of the melatonin metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), in cerebrospinal fluid (CSF) of patients with viral meningitis (n = 20) and control samples (n = 8) and correlate AFMK levels with inflammatory markers such as cellularity, protein, tumor necrosis factor (TNF)-alpha, interleukin (IL)-8 and IL-1beta levels.	Melatonin	33-42	interleukin 1 beta	Homo sapiens	342-350
16253096-5	2005	RESULTS: PGE2 biosynthesis was dose dependently inhibited by both triclosan and triclosan and CPC when challenged by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta.	Dinoprostone	9-13	interleukin 1 beta	Homo sapiens	154-176
16253096-5	2005	RESULTS: PGE2 biosynthesis was dose dependently inhibited by both triclosan and triclosan and CPC when challenged by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta.	Triclosan	66-75	interleukin 1 beta	Homo sapiens	154-176
16253096-5	2005	RESULTS: PGE2 biosynthesis was dose dependently inhibited by both triclosan and triclosan and CPC when challenged by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta.	Triclosan	80-89	interleukin 1 beta	Homo sapiens	154-176
16253096-6	2005	At pharmacologically relevant concentrations, triclosan and CPC inhibited IL-1beta-induced PGE2 production to a greater extent than triclosan alone (P = 0.02).	Triclosan	46-55	interleukin 1 beta	Homo sapiens	74-82
16253096-6	2005	At pharmacologically relevant concentrations, triclosan and CPC inhibited IL-1beta-induced PGE2 production to a greater extent than triclosan alone (P = 0.02).	Cetylpyridinium	60-63	interleukin 1 beta	Homo sapiens	74-82
16253096-6	2005	At pharmacologically relevant concentrations, triclosan and CPC inhibited IL-1beta-induced PGE2 production to a greater extent than triclosan alone (P = 0.02).	Dinoprostone	91-95	interleukin 1 beta	Homo sapiens	74-82
16253096-7	2005	Moreover, enhanced COX-2 mRNA repression was observed with triclosan and CPC in comparison to triclosan alone in IL-1beta and TNF-alpha stimulated cells.	Triclosan	59-68	interleukin 1 beta	Homo sapiens	113-121
16132116-0	2005	Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells.	Acetaldehyde	0-12	interleukin 1 beta	Homo sapiens	21-38
16132116-0	2005	Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells.	Berberine	98-107	interleukin 1 beta	Homo sapiens	21-38
16132116-3	2005	However, the direct effect of alcohol in the induction of IL-1beta and TNF-alpha has not been clarified.	Alcohols	30-37	interleukin 1 beta	Homo sapiens	58-66
16132116-4	2005	In this study, we demonstrated that acetaldehyde, the metabolic product of ethanol, was able to induce IL-1beta and TNF-alpha production in HepG2 cells.	Acetaldehyde	36-48	interleukin 1 beta	Homo sapiens	103-111
16132116-4	2005	In this study, we demonstrated that acetaldehyde, the metabolic product of ethanol, was able to induce IL-1beta and TNF-alpha production in HepG2 cells.	Ethanol	75-82	interleukin 1 beta	Homo sapiens	103-111
16132116-7	2005	Therefore, these data suggested that acetaldehyde stimulated IL-1beta and TNF-alpha production via the regulation of NF-kappaB signaling pathway.	Acetaldehyde	37-49	interleukin 1 beta	Homo sapiens	61-69
16202926-7	2005	Treatment with IL-1beta also inhibited the uptake of arginine, and glutamate but had no significant effect on the uptake of leucine, tryptophan, and ascorbate.	Arginine	53-61	interleukin 1 beta	Homo sapiens	15-23
16202926-7	2005	Treatment with IL-1beta also inhibited the uptake of arginine, and glutamate but had no significant effect on the uptake of leucine, tryptophan, and ascorbate.	Glutamic Acid	67-76	interleukin 1 beta	Homo sapiens	15-23
16157236-6	2005	In addition, DL-homocysteine at the pathophysiologic dose of 25 microg/mL (185 microM) induced mRNA and protein expressions of inflammatory cytokines tumor necrosis factor-alpha, IL-1beta, interleukin-6, interleukin-8, and interleukin-12.	DL-Homocysteine	13-28	interleukin 1 beta	Homo sapiens	179-187
16206353-7	2005	EGCg was more efficient in modulating the effects of IL-1beta on the genes studied.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	53-61
16206353-8	2005	Whereas EGCg inhibited the IL-1beta-activated MAPK, NF-kappaB, and AP-1, Se-met stimulated that signaling pathway.	epigallocatechin gallate	8-12	interleukin 1 beta	Homo sapiens	27-35
21794254-5	2005	OBJECTIVES: To analyze the effect of CS and HA (500-730 kDa) on MMP-3 and MMP-1 synthesis induced by interleukin-1beta (IL-1beta) in OA chondrocytes.	Chondroitin Sulfates	37-39	interleukin 1 beta	Homo sapiens	101-118
15990992-6	2005	By contrast, GLS mRNA levels in IL-1beta-stimulated FLSs were reduced by treatment with aurothioglucose (AuTG) and dexamethasone (DEX).	Aurothioglucose	88-103	interleukin 1 beta	Homo sapiens	32-40
15990992-6	2005	By contrast, GLS mRNA levels in IL-1beta-stimulated FLSs were reduced by treatment with aurothioglucose (AuTG) and dexamethasone (DEX).	Dexamethasone	115-128	interleukin 1 beta	Homo sapiens	32-40
15990992-6	2005	By contrast, GLS mRNA levels in IL-1beta-stimulated FLSs were reduced by treatment with aurothioglucose (AuTG) and dexamethasone (DEX).	Dexamethasone	130-133	interleukin 1 beta	Homo sapiens	32-40
16140223-10	2005	Inhaled steroids resulted in reduced levels of IL-1 beta, IL-6, IL-8, IL-10, and IL-12 (all: P&lt;0.01) in stable COPD (all: ex-smokers) with dose dependency for IL-8, IL-1 beta and IL-12.	Steroids	8-16	interleukin 1 beta	Homo sapiens	47-56
16140223-10	2005	Inhaled steroids resulted in reduced levels of IL-1 beta, IL-6, IL-8, IL-10, and IL-12 (all: P&lt;0.01) in stable COPD (all: ex-smokers) with dose dependency for IL-8, IL-1 beta and IL-12.	Steroids	8-16	interleukin 1 beta	Homo sapiens	168-177
21794254-5	2005	OBJECTIVES: To analyze the effect of CS and HA (500-730 kDa) on MMP-3 and MMP-1 synthesis induced by interleukin-1beta (IL-1beta) in OA chondrocytes.	Chondroitin Sulfates	37-39	interleukin 1 beta	Homo sapiens	120-128
21794254-8	2005	RESULTS: CS and HA inhibited IL-1beta-induced MMP-3 synthesis, without significantly modifying MMP-1.	Chondroitin Sulfates	9-11	interleukin 1 beta	Homo sapiens	29-37
16109311-6	2005	Furthermore, both IL-1beta and TNF-alpha induced the production of H(2)O(2).	Hydrogen Peroxide	67-75	interleukin 1 beta	Homo sapiens	18-26
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	Acetylcysteine	166-182	interleukin 1 beta	Homo sapiens	20-28
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	Acetylcysteine	184-187	interleukin 1 beta	Homo sapiens	20-28
16014734-9	2005	Since increased cell proliferation and the release of TNF-alpha and IL-1beta are believed to be involved in tumor promotion, our results suggest that tt-DDE may play a role in cancer promotion.	tt-dde	150-156	interleukin 1 beta	Homo sapiens	68-76
15890711-5	2005	Normal muscle incubated (2 h) in IL-1beta and IL-6 had increases in H2O2, PGE2, and PAF levels.	Hydrogen Peroxide	68-72	interleukin 1 beta	Homo sapiens	33-41
15677552-4	2005	Treatment with IL-1beta induced an approximate 30-fold increase in the levels of hyaluronan in the medium of human jejunum-derived mesenchymal cells.	Hyaluronic Acid	81-91	interleukin 1 beta	Homo sapiens	15-23
15677552-8	2005	IL-1beta induction of hyaluronan expression was inhibited in cells transfected with short interfering RNA corresponding to HAS2 transcripts.	Hyaluronic Acid	22-32	interleukin 1 beta	Homo sapiens	0-8
15677552-9	2005	Inhibitors of the p38 and ERK1/2 mitogen-activated pathways but not JNK/SAPK blocked the IL-1beta-mediated induction of hyaluronan expression and the increase in HAS2 transcript expression.	Hyaluronic Acid	120-130	interleukin 1 beta	Homo sapiens	89-97
15677552-10	2005	These results suggest that IL-1beta induction of HAS2 expression involves multiple signaling pathways that act in concert, thus leading to an increase in expression of hyaluronan by jejunum-derived mesenchymal cells.	Hyaluronic Acid	168-178	interleukin 1 beta	Homo sapiens	27-35
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	193-220	interleukin 1 beta	Homo sapiens	20-28
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	222-226	interleukin 1 beta	Homo sapiens	20-28
15879491-9	2005	In vitro study showed that both olmesartan and its active metabolite RNH-6270 suppressed IL-1beta production in U-937 cells and cultured myocytes.	olmesartan	32-42	interleukin 1 beta	Homo sapiens	89-97
15879491-9	2005	In vitro study showed that both olmesartan and its active metabolite RNH-6270 suppressed IL-1beta production in U-937 cells and cultured myocytes.	N-heptylpantothenamide	69-72	interleukin 1 beta	Homo sapiens	89-97
15890711-5	2005	Normal muscle incubated (2 h) in IL-1beta and IL-6 had increases in H2O2, PGE2, and PAF levels.	Dinoprostone	74-78	interleukin 1 beta	Homo sapiens	33-41
15890711-9	2005	Finally, in normal muscle strips treated with IL-1beta electrical field stimulation (EFS)-induced contraction was partially restored by indomethacin or by the PAF antagonist CV3988 and was completely restored by the combination of CV3988 and indomethacin, whereas in strips treated with IL-6, EFS-induced contraction was partially restored by the PAF antagonist CV3988 and not affected by indomethacin.	Indomethacin	136-148	interleukin 1 beta	Homo sapiens	46-54
15890711-9	2005	Finally, in normal muscle strips treated with IL-1beta electrical field stimulation (EFS)-induced contraction was partially restored by indomethacin or by the PAF antagonist CV3988 and was completely restored by the combination of CV3988 and indomethacin, whereas in strips treated with IL-6, EFS-induced contraction was partially restored by the PAF antagonist CV3988 and not affected by indomethacin.	CV 3988	174-180	interleukin 1 beta	Homo sapiens	46-54
15890711-9	2005	Finally, in normal muscle strips treated with IL-1beta electrical field stimulation (EFS)-induced contraction was partially restored by indomethacin or by the PAF antagonist CV3988 and was completely restored by the combination of CV3988 and indomethacin, whereas in strips treated with IL-6, EFS-induced contraction was partially restored by the PAF antagonist CV3988 and not affected by indomethacin.	CV 3988	231-237	interleukin 1 beta	Homo sapiens	46-54
15890711-9	2005	Finally, in normal muscle strips treated with IL-1beta electrical field stimulation (EFS)-induced contraction was partially restored by indomethacin or by the PAF antagonist CV3988 and was completely restored by the combination of CV3988 and indomethacin, whereas in strips treated with IL-6, EFS-induced contraction was partially restored by the PAF antagonist CV3988 and not affected by indomethacin.	Indomethacin	242-254	interleukin 1 beta	Homo sapiens	46-54
15890711-9	2005	Finally, in normal muscle strips treated with IL-1beta electrical field stimulation (EFS)-induced contraction was partially restored by indomethacin or by the PAF antagonist CV3988 and was completely restored by the combination of CV3988 and indomethacin, whereas in strips treated with IL-6, EFS-induced contraction was partially restored by the PAF antagonist CV3988 and not affected by indomethacin.	CV 3988	231-237	interleukin 1 beta	Homo sapiens	46-54
15890711-9	2005	Finally, in normal muscle strips treated with IL-1beta electrical field stimulation (EFS)-induced contraction was partially restored by indomethacin or by the PAF antagonist CV3988 and was completely restored by the combination of CV3988 and indomethacin, whereas in strips treated with IL-6, EFS-induced contraction was partially restored by the PAF antagonist CV3988 and not affected by indomethacin.	Indomethacin	242-254	interleukin 1 beta	Homo sapiens	46-54
15890711-10	2005	We conclude that IL-1beta-induced production of H2O2 causes formation of PGE2 and PAF that inhibit ACh release from esophageal cholinergic neurons without affecting ACh-induced contraction of esophageal circular muscle.	Hydrogen Peroxide	48-52	interleukin 1 beta	Homo sapiens	17-25
15890711-10	2005	We conclude that IL-1beta-induced production of H2O2 causes formation of PGE2 and PAF that inhibit ACh release from esophageal cholinergic neurons without affecting ACh-induced contraction of esophageal circular muscle.	Dinoprostone	73-77	interleukin 1 beta	Homo sapiens	17-25
15890711-10	2005	We conclude that IL-1beta-induced production of H2O2 causes formation of PGE2 and PAF that inhibit ACh release from esophageal cholinergic neurons without affecting ACh-induced contraction of esophageal circular muscle.	Acetylcholine	99-102	interleukin 1 beta	Homo sapiens	17-25
15890711-10	2005	We conclude that IL-1beta-induced production of H2O2 causes formation of PGE2 and PAF that inhibit ACh release from esophageal cholinergic neurons without affecting ACh-induced contraction of esophageal circular muscle.	Acetylcholine	165-168	interleukin 1 beta	Homo sapiens	17-25
15901641-6	2005	Curcumin (10(-8) M), which is known for inhibiting NFkappaB activation, inhibited IL1B-induced MIF secretion as well as NFkappaB nuclear translocation and DNA binding.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	82-86
15963685-6	2005	A whole blood method was used to determine lipopolysaccharide-(LPS) and peptidoglycan-(PGN) stimulated IL-6, IL-1beta, and TNF-alpha production with supernatants analyzed using ELISA.	pgn	87-90	interleukin 1 beta	Homo sapiens	109-117
16141532-7	2005	Interestingly, A23187 synergized with the activities of CKBM-treated THP-1 cells in terms of IL-1beta and IFNgamma production, while the IL-10 production showed no synergistic relationship between CKBM and A23187.	Calcimycin	15-21	interleukin 1 beta	Homo sapiens	93-101
16141532-7	2005	Interestingly, A23187 synergized with the activities of CKBM-treated THP-1 cells in terms of IL-1beta and IFNgamma production, while the IL-10 production showed no synergistic relationship between CKBM and A23187.	ckbm	56-60	interleukin 1 beta	Homo sapiens	93-101
16141576-0	2005	Synthesis and inhibitory effect of novel glycyrrhetinic acid derivatives on IL-1 beta-induced prostaglandin E(2) production in normal human dermal fibroblasts.	Glycyrrhetinic Acid	41-60	interleukin 1 beta	Homo sapiens	76-85
16140971-7	2005	To delineate the signaling mechanism from 16-kDa PRL, we examined the effect of 16-kDa PRL on interleukin IL-1beta-inducible iNOS expression, which is regulated by two parallel pathways, one involving IFN regulatory factor 1 (IRF-1) and the other nuclear factor-kappaB (NF-kappaB).	16-kda	42-48	interleukin 1 beta	Homo sapiens	106-114
16140971-7	2005	To delineate the signaling mechanism from 16-kDa PRL, we examined the effect of 16-kDa PRL on interleukin IL-1beta-inducible iNOS expression, which is regulated by two parallel pathways, one involving IFN regulatory factor 1 (IRF-1) and the other nuclear factor-kappaB (NF-kappaB).	16-kda	80-86	interleukin 1 beta	Homo sapiens	106-114
16140971-9	2005	We found that IL-1beta regulated IRF-1 gene expression through stimulation of p38 mitogen-activated protein kinase (MAPK), which mediated signal transducer and activator of transcription 1 (Stat1) serine phosphorylation and Stat1 nuclear translocation to activate the IRF-1 promoter.	Serine	197-203	interleukin 1 beta	Homo sapiens	14-22
16140971-10	2005	16-kDa PRL effectively inhibited IL-1beta-inducible p38 MAPK phosphorylation, resulting in blocking Stat1 serine phosphorylation, its subsequent nuclear translocation and activation of the Stat1 target gene IRF-1.	16-kda	0-6	interleukin 1 beta	Homo sapiens	33-41
16140971-10	2005	16-kDa PRL effectively inhibited IL-1beta-inducible p38 MAPK phosphorylation, resulting in blocking Stat1 serine phosphorylation, its subsequent nuclear translocation and activation of the Stat1 target gene IRF-1.	Serine	106-112	interleukin 1 beta	Homo sapiens	33-41
16141576-0	2005	Synthesis and inhibitory effect of novel glycyrrhetinic acid derivatives on IL-1 beta-induced prostaglandin E(2) production in normal human dermal fibroblasts.	Dinoprostone	94-112	interleukin 1 beta	Homo sapiens	76-85
16141576-3	2005	These were screened for their inhibitory activity against interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production in normal human dermal fibroblasts (NHDF).	Dinoprostone	97-115	interleukin 1 beta	Homo sapiens	58-76
16141576-3	2005	These were screened for their inhibitory activity against interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production in normal human dermal fibroblasts (NHDF).	Dinoprostone	97-115	interleukin 1 beta	Homo sapiens	78-87
16141576-3	2005	These were screened for their inhibitory activity against interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production in normal human dermal fibroblasts (NHDF).	Prostaglandins E	117-120	interleukin 1 beta	Homo sapiens	58-76
16141576-3	2005	These were screened for their inhibitory activity against interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production in normal human dermal fibroblasts (NHDF).	Prostaglandins E	117-120	interleukin 1 beta	Homo sapiens	78-87
16123345-0	2005	Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+.	Nitric Oxide	69-81	interleukin 1 beta	Homo sapiens	43-60
16123345-2	2005	In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1beta-induced nitric oxide (NO) release in the isolated beta-cell.	Cholesterol	87-98	interleukin 1 beta	Homo sapiens	210-218
16123345-3	2005	Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1beta-induced gene expression of inducible NO synthase (iNOS) and NO release from beta-cells.	Cyclodextrins	38-50	interleukin 1 beta	Homo sapiens	69-77
16123345-4	2005	Immunologic and confocal microscopic evidence also suggested a transient but significant stimulation of tyrosine phosphorylation of Cav-1 in beta-cells briefly (for 15 min) exposed to IL-1beta that was markedly attenuated by three structurally distinct inhibitors of protein tyrosine phosphorylation.	Tyrosine	104-112	interleukin 1 beta	Homo sapiens	184-192
16123345-4	2005	Immunologic and confocal microscopic evidence also suggested a transient but significant stimulation of tyrosine phosphorylation of Cav-1 in beta-cells briefly (for 15 min) exposed to IL-1beta that was markedly attenuated by three structurally distinct inhibitors of protein tyrosine phosphorylation.	Tyrosine	275-283	interleukin 1 beta	Homo sapiens	184-192
16123345-5	2005	Overexpression of an inactive mutant of Cav-1 lacking the tyrosine phosphorylation site (Y14F) or an siRNA-mediated Cav-1 knock down also resulted in marked attenuation of IL-1beta-induced iNOS gene expression and NO release from these cells, thus further implicating Cav-1 in this signaling cascade.	Tyrosine	58-66	interleukin 1 beta	Homo sapiens	172-180
16123345-7	2005	Here we provide the first evidence to suggest that tyrosine phosphorylation of Cav-1 and subsequent interaction among members of the Ras signaling pathway within the membrane lipid microdomains represent early signaling mechanisms of IL-1beta in beta-cells.	Tyrosine	51-59	interleukin 1 beta	Homo sapiens	234-242
16099623-2	2005	We determined the effect of penicillin treatment of Streptococcus pneumoniae on the induction of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) genes by human macrophages and the influence of antibiotic concentration and bacterial growth phase upon this induction.	Penicillins	28-38	interleukin 1 beta	Homo sapiens	161-169
16024094-1	2005	We have examined the impact of the inflammatory cytokines interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) on assembly of nAChRs from subunit mixtures of nAChRalpha4, beta2 and beta4 transiently transfected into 293 cells.	nachrs	146-152	interleukin 1 beta	Homo sapiens	58-76
15961160-4	2005	The seven genes found to be significantly up-regulated by aluminum encode pro-inflammatory or pro-apoptotic signaling elements, including NF-kappaB subunits, interleukin-1beta precursor, cytosolic phospholipase A2, cyclooxygenase-2, beta-amyloid precursor protein and DAXX, a regulatory protein known to induce apoptosis and repress transcription.	Aluminum	58-66	interleukin 1 beta	Homo sapiens	158-175
16140882-10	2005	PFE inhibited the IL-1beta-induced proteoglycan breakdown in cartilage explants in vitro.	Coconut Oil	0-3	interleukin 1 beta	Homo sapiens	18-26
16273336-3	2005	OBJECTIVE: To determine if the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1) from brain endothelium corresponds to the incidence of amphotericin fever.	Amphotericin B	167-179	interleukin 1 beta	Homo sapiens	86-104
16273336-3	2005	OBJECTIVE: To determine if the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1) from brain endothelium corresponds to the incidence of amphotericin fever.	Amphotericin B	167-179	interleukin 1 beta	Homo sapiens	106-110
16273336-4	2005	RESULTS: Release of TNF-alpha and IL-1beta after L-Amph treatment was similar to negative controls while after d-Amph treatment release was similar to lipopolysaccharide.	l-amph	49-55	interleukin 1 beta	Homo sapiens	34-42
16052481-9	2005	Garcinol also significantly inhibited the expression of MMP-7 in IL-1beta-induced HT-29 cells.	garcinol	0-8	interleukin 1 beta	Homo sapiens	65-73
16140882-11	2005	At the cellular level, PFE (6.25-25 mg/L) inhibited the IL-1beta-induced expression of MMP-1, -3, and -13 protein in the medium (P &lt; 0.05) and this was associated with the inhibition of mRNA expression.	Coconut Oil	23-26	interleukin 1 beta	Homo sapiens	56-64
16024094-1	2005	We have examined the impact of the inflammatory cytokines interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) on assembly of nAChRs from subunit mixtures of nAChRalpha4, beta2 and beta4 transiently transfected into 293 cells.	nachrs	146-152	interleukin 1 beta	Homo sapiens	78-86
16140882-12	2005	IL-1beta-induced phosphorylation of p38-MAPK, but not that of c-Jun-N-terminal kinase or extracellular regulated kinase, was most susceptible to inhibition by low doses of PFE, and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay.	Coconut Oil	172-175	interleukin 1 beta	Homo sapiens	0-8
16140882-12	2005	IL-1beta-induced phosphorylation of p38-MAPK, but not that of c-Jun-N-terminal kinase or extracellular regulated kinase, was most susceptible to inhibition by low doses of PFE, and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay.	Coconut Oil	197-200	interleukin 1 beta	Homo sapiens	0-8
16155407-7	2005	Interestingly, unlike other proinflammatory cytokines, such as TNF-alpha and IL-1beta, a time-dependent experiment revealed that DFO slowly induces CCL20, suggesting a novel mechanism of action.	Deferoxamine	129-132	interleukin 1 beta	Homo sapiens	77-85
16140882-13	2005	PFE also inhibited the IL-1beta-induced phosphorylation of IkappaBalpha and the DNA binding activity of the transcription factor NF-kappaB in OA chondrocytes.	Coconut Oil	0-3	interleukin 1 beta	Homo sapiens	23-31
15993849-4	2005	Ethanol also inhibited by 49% the IL-1beta stimulated translocation of the p65 subunit of NFkappaB from the cytoplasm into the nucleus.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	34-42
16191354-1	2005	OBJECTIVE: To evaluate the effects of doxycycline on the regulation of intercellular adhesion molecule-1 (ICAM-1, CD54), interleukin-1beta (IL-1beta), human leukocyte antigen DR (HLA-DR) and apoptosis in human conjunctival epithelial cells.	Doxycycline	38-49	interleukin 1 beta	Homo sapiens	121-138
16191354-8	2005	Doxycycline and dexamethasone inhibited the IFN-gamma induced increase of express of CD54 and IL-1beta of cultured conjunctival epithelial cells, and the inhibiting effect was dependent on the concentration of doxycycline (P &lt; 0.01).	Doxycycline	0-11	interleukin 1 beta	Homo sapiens	94-102
15967798-3	2005	Here we show that iron and interleukin-1beta (IL-1beta) act synergistically to increase H- and L-ferritin expression in hepatoma cells.	Iron	18-22	interleukin 1 beta	Homo sapiens	46-54
16026998-0	2005	Adenosine inhibits the release of interleukin-1beta in activated human peripheral mononuclear cells.	Adenosine	0-9	interleukin 1 beta	Homo sapiens	34-51
16026998-1	2005	The effects of adenosine and subtype-specific activators of adenosine receptors (A1, A2A, A2B and A3) were studied on the release of interleukin-1beta (IL-1beta) from peripheral mononuclear cells, monocytes and lymphocytes.	Adenosine	15-24	interleukin 1 beta	Homo sapiens	133-150
16026998-1	2005	The effects of adenosine and subtype-specific activators of adenosine receptors (A1, A2A, A2B and A3) were studied on the release of interleukin-1beta (IL-1beta) from peripheral mononuclear cells, monocytes and lymphocytes.	Adenosine	15-24	interleukin 1 beta	Homo sapiens	152-160
16026998-2	2005	In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release.	Phorbol Esters	56-69	interleukin 1 beta	Homo sapiens	284-292
16026998-2	2005	In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release.	Tetradecanoylphorbol Acetate	71-102	interleukin 1 beta	Homo sapiens	284-292
16026998-2	2005	In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release.	Calcimycin	126-132	interleukin 1 beta	Homo sapiens	284-292
16026998-2	2005	In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release.	Adenosine	139-148	interleukin 1 beta	Homo sapiens	284-292
16191354-8	2005	Doxycycline and dexamethasone inhibited the IFN-gamma induced increase of express of CD54 and IL-1beta of cultured conjunctival epithelial cells, and the inhibiting effect was dependent on the concentration of doxycycline (P &lt; 0.01).	Dexamethasone	16-29	interleukin 1 beta	Homo sapiens	94-102
16191354-8	2005	Doxycycline and dexamethasone inhibited the IFN-gamma induced increase of express of CD54 and IL-1beta of cultured conjunctival epithelial cells, and the inhibiting effect was dependent on the concentration of doxycycline (P &lt; 0.01).	Doxycycline	210-221	interleukin 1 beta	Homo sapiens	94-102
16191354-10	2005	CONCLUSION: Doxycycline can suppress the expression of inflammatory cytokine such as CD54 and IL-1beta, which suggests that doxycycline may be a potent drug for the treatment of ocular surface inflammatory disease.	Doxycycline	12-23	interleukin 1 beta	Homo sapiens	94-102
16191354-10	2005	CONCLUSION: Doxycycline can suppress the expression of inflammatory cytokine such as CD54 and IL-1beta, which suggests that doxycycline may be a potent drug for the treatment of ocular surface inflammatory disease.	Doxycycline	124-135	interleukin 1 beta	Homo sapiens	94-102
16026998-3	2005	The rank order of potency in the inhibition of IL-1beta release was CPA=CGS 21680&gt;IB-MECA&gt;adenosine&gt;NECA (in the presence of A1, A2A and A3 receptor inhibitors).	N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine	85-92	interleukin 1 beta	Homo sapiens	47-55
16026998-3	2005	The rank order of potency in the inhibition of IL-1beta release was CPA=CGS 21680&gt;IB-MECA&gt;adenosine&gt;NECA (in the presence of A1, A2A and A3 receptor inhibitors).	Adenosine	96-105	interleukin 1 beta	Homo sapiens	47-55
16026998-3	2005	The rank order of potency in the inhibition of IL-1beta release was CPA=CGS 21680&gt;IB-MECA&gt;adenosine&gt;NECA (in the presence of A1, A2A and A3 receptor inhibitors).	Adenosine-5'-(N-ethylcarboxamide)	109-113	interleukin 1 beta	Homo sapiens	47-55
16026998-5	2005	It can be concluded that adenosine inhibits the release of IL-1beta from the activated human peripheral mononuclear cells.	Adenosine	25-34	interleukin 1 beta	Homo sapiens	59-67
15993849-3	2005	Exposure of A549 to ethanol (0.1-1%) dose-dependently inhibited (by 15-49%) the release of G-CSF and IL-8, but not of M-CSF, triggered by IL1beta or TNFalpha.	Ethanol	20-27	interleukin 1 beta	Homo sapiens	138-145
15993849-5	2005	Using a kappaB binding and luciferase coupled construct, transfected into A549 cells, we found that 1% ethanol specifically reduced IL-1beta and TNFalpha induced luciferase activity with 34 and 40%, respectively.	Ethanol	103-110	interleukin 1 beta	Homo sapiens	132-140
15996190-0	2005	Actinobacillus actinomycetemcomitans Y4 capsular polysaccharide induces IL-1beta mRNA expression through the JNK pathway in differentiated THP-1 cells.	y4 capsular polysaccharide	37-63	interleukin 1 beta	Homo sapiens	72-80
15979578-5	2005	The opioid-induced increase in IL-1 beta was blocked by naltrexone in the group tested.	Naltrexone	56-66	interleukin 1 beta	Homo sapiens	31-40
16048981-0	2005	Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism.	Nystatin	0-8	interleukin 1 beta	Homo sapiens	30-52
16048981-2	2005	Herein, we demonstrate that nystatin induces interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha secretion through its activation of toll-like receptor 1 (TLR1) and TLR2.	Nystatin	28-36	interleukin 1 beta	Homo sapiens	45-67
16100443-2	2005	To investigate the mechanism of IL-1beta-induced cell death in human malignant melanoma A375-S2 cells, MTT assay, photomicroscopical observation, DNA agarose gel electrophoresis, radioimmunoassay and Western blot analysis were carried out.	monooxyethylene trimethylolpropane tristearate	103-106	interleukin 1 beta	Homo sapiens	32-40
16096456-12	2005	Addition of DHEA to the culture medium, however, significantly improved the release of interleukin-1beta and tumor necrosis factor-alpha and stimulated the interleukin-6 release capacity of PBMC.	Dehydroepiandrosterone	12-16	interleukin 1 beta	Homo sapiens	87-136
16021603-4	2005	NOD1 activation by low nanomolar concentrations of the specific muropeptide ligand M-TriDAP induced minimal human peripheral blood mononuclear cell TNF-alpha, IL-1beta or IL-10 secretion, but synergistically increased Toll-like receptor (TLR)-induced responses.	L-Ala-gamma-D-Glu-meso-diaminopimelic acid	85-91	interleukin 1 beta	Homo sapiens	159-167
16100443-2	2005	To investigate the mechanism of IL-1beta-induced cell death in human malignant melanoma A375-S2 cells, MTT assay, photomicroscopical observation, DNA agarose gel electrophoresis, radioimmunoassay and Western blot analysis were carried out.	Sepharose	150-157	interleukin 1 beta	Homo sapiens	32-40
15948176-1	2005	Interleukin-1 beta (IL-1beta) is one of the main cytokines involved in the inflammatory response; it has multiple effects that can contribute to cell damage, one of which is the upregulation of the inducible form of nitric oxide (NO) synthase (NOS2) in certain cell types.	Nitric Oxide	216-228	interleukin 1 beta	Homo sapiens	0-18
16079470-7	2005	Furthermore, pretreatment of U937 cells with anti-TNFalpha and anti-IL-1beta antibodies blocked oridonin-induced phagocytic stimulation as well as phosphorylation of ERK, but did not block the activation of PKC, indicating that these signaling events are triggered by oridonin, whereas secreted TNFalpha or IL-1beta only activate the ERK-dependent pathway.	oridonin	96-104	interleukin 1 beta	Homo sapiens	68-76
15948176-1	2005	Interleukin-1 beta (IL-1beta) is one of the main cytokines involved in the inflammatory response; it has multiple effects that can contribute to cell damage, one of which is the upregulation of the inducible form of nitric oxide (NO) synthase (NOS2) in certain cell types.	Nitric Oxide	216-228	interleukin 1 beta	Homo sapiens	20-28
16079470-7	2005	Furthermore, pretreatment of U937 cells with anti-TNFalpha and anti-IL-1beta antibodies blocked oridonin-induced phagocytic stimulation as well as phosphorylation of ERK, but did not block the activation of PKC, indicating that these signaling events are triggered by oridonin, whereas secreted TNFalpha or IL-1beta only activate the ERK-dependent pathway.	oridonin	268-276	interleukin 1 beta	Homo sapiens	68-76
15923130-1	2005	OBJECTIVE: This study investigated the in vitro effects of hyaluronic acid (HA) of molecular weight (MW) 500-730 kDa on human articular chondrocytes cultivated for 48 h in the presence of interleukin-1beta (IL-1beta) with and without hydrostatic cyclical pressure.	Hyaluronic Acid	59-74	interleukin 1 beta	Homo sapiens	188-205
15900018-1	2005	The ability of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) to induce the major inflammatory mediator prostaglandin (PG) E(2) depends on the activation of two rate-limiting enzymes, phospholipase A(2) (PLA(2)) and cyclooxygenase 2 (COX-2).	Prostaglandins E	121-141	interleukin 1 beta	Homo sapiens	50-67
15900018-1	2005	The ability of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) to induce the major inflammatory mediator prostaglandin (PG) E(2) depends on the activation of two rate-limiting enzymes, phospholipase A(2) (PLA(2)) and cyclooxygenase 2 (COX-2).	Prostaglandins E	121-141	interleukin 1 beta	Homo sapiens	69-77
15811958-3	2005	We demonstrated that indole-3-carbinol suppressed constitutive NF-kappaB activation and activation induced by tumor necrosis factor (TNF), interleukin-1beta (IL-1beta), phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide (LPS), and cigarette smoke; the suppression was not cell type specific, because activation was inhibited in myeloid, leukemia, and epithelial cells.	indole-3-carbinol	21-38	interleukin 1 beta	Homo sapiens	139-156
15811958-3	2005	We demonstrated that indole-3-carbinol suppressed constitutive NF-kappaB activation and activation induced by tumor necrosis factor (TNF), interleukin-1beta (IL-1beta), phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide (LPS), and cigarette smoke; the suppression was not cell type specific, because activation was inhibited in myeloid, leukemia, and epithelial cells.	indole-3-carbinol	21-38	interleukin 1 beta	Homo sapiens	158-166
15954968-6	2005	Interleukin 1beta was similarly greater with desflurane than sevoflurane before (39.3 +/- 4.0 pg ml(-1) vs. 17.4 +/- 3.0 pg ml(-1); P &lt; 0.01) and after surgery (46.0 +/- 3.4 pg ml(-1) vs. 23.3 +/- 3.2 pg ml(-1), P &lt; 0.001).	Desflurane	45-55	interleukin 1 beta	Homo sapiens	0-17
16002736-7	2005	Dexamethasone completely blocked the effect of IL-1beta on IL-6 expression.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	47-55
15954968-9	2005	Alveolar cell TNFalpha concentrations after surgery were also greater with desflurane than sevoflurane (96.3 +/- 12.4 pg ml(-1) vs. 64.8 +/- 10.1 pg ml(-1), P &lt; 0.001), as were interleukin 1beta (75.4 +/- 6.2 pg ml(-1) vs. 32.0 +/- 8.3 pg ml(-1), P &lt; 0.001) and interleukin 6 concentrations (540.1 +/- 65.3 pg ml(-1) vs. 363.6 +/- 29.2 pg ml(-1), P &lt; 0.001).	Desflurane	75-85	interleukin 1 beta	Homo sapiens	180-197
15769938-10	2005	Sirolimus overrode the suppression of cholesterol efflux and ABCA1 gene expression induced by the inflammatory cytokine IL-1beta.	Sirolimus	0-9	interleukin 1 beta	Homo sapiens	120-128
15769938-10	2005	Sirolimus overrode the suppression of cholesterol efflux and ABCA1 gene expression induced by the inflammatory cytokine IL-1beta.	Cholesterol	38-49	interleukin 1 beta	Homo sapiens	120-128
15990776-6	2005	METHODS: Cultured HASMCs were stimulated with IL-1beta, TNF-alpha, and IFN-gamma and treated with (R)-enantiomers and (S)-enantiomers of albuterol and formoterol, with and without propranolol and ICI-118,551, and in combination with dexamethasone.	hasmcs	18-24	interleukin 1 beta	Homo sapiens	46-54
15974887-6	2005	Preincubated IL-1beta elevated the intracellular cAMP response to exogenous administered AM.	Cyclic AMP	49-53	interleukin 1 beta	Homo sapiens	13-21
15974887-8	2005	IL-1beta significantly increased (3)H-proline incorporation and AM antisense oligodeoxynucleotide treatment further increased (3)H-proline incorporation.	h-proline	36-45	interleukin 1 beta	Homo sapiens	0-8
15994384-4	2005	IL-1beta (10 ng x mL(-1); 21 degrees C; 15 h) increased the release of NGF from human isolated bronchi in vitro, and, in organ bath studies, the response of human bronchi to [Sar9,Met(O2)11]-substance P (0.1 microm).	Oxygen	184-186	interleukin 1 beta	Homo sapiens	0-8
16029022-2	2005	The IL-1beta(163-171) fragment known to reproduce the immunostimulatory and adjuvant effects of the whole IL-1beta without possessing any of the pro-inflammatory properties of IL-1beta was covalently anchored to the N-terminus of the Sequential Oligopeptide Carrier, SOC(n), formed by the repeating tripeptide unit Lys-Aib-Gly.	tripeptide K-26	299-309	interleukin 1 beta	Homo sapiens	4-12
15966973-2	2005	Ah-2743 caused significantly higher serum levels of tumour necrosis factor-alpha, interleukin (IL)-1beta or IL-6 in human whole blood, and higher serum IL-1beta and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922.	ah-2743	0-7	interleukin 1 beta	Homo sapiens	82-104
15966973-2	2005	Ah-2743 caused significantly higher serum levels of tumour necrosis factor-alpha, interleukin (IL)-1beta or IL-6 in human whole blood, and higher serum IL-1beta and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922.	ah-2743	0-7	interleukin 1 beta	Homo sapiens	152-160
15914333-7	2005	Anti-IL-1beta neutralizing antibody, but not anti-TNFalpha neutralizing antibody, completely inhibited PGE(2) induction by PBMC supernatant.	Prostaglandins E	103-106	interleukin 1 beta	Homo sapiens	5-13
15914333-8	2005	These results suggest that FK506 suppresses inflammation by inhibiting PGE(2) production from synovial cells through suppression of IL-1beta production from leukocytes.	Tacrolimus	27-32	interleukin 1 beta	Homo sapiens	132-140
15980221-6	2005	RESULTS: Both triptolide and dexamethasone inhibited in a dose-dependent manner the expression of IL-8 and MCP-1 in corneal fibroblasts induced by the proinflammatory cytokines IL-1beta or tumor necrosis factor (TNF)-alpha.	triptolide	14-24	interleukin 1 beta	Homo sapiens	177-185
15980221-6	2005	RESULTS: Both triptolide and dexamethasone inhibited in a dose-dependent manner the expression of IL-8 and MCP-1 in corneal fibroblasts induced by the proinflammatory cytokines IL-1beta or tumor necrosis factor (TNF)-alpha.	Dexamethasone	29-42	interleukin 1 beta	Homo sapiens	177-185
15980221-9	2005	The activation of NF-kappaB by IL-1beta was markedly inhibited by both triptolide and dexamethasone, whereas the activity of AP-1 was not affected by either agent.	triptolide	71-81	interleukin 1 beta	Homo sapiens	31-39
15980221-9	2005	The activation of NF-kappaB by IL-1beta was markedly inhibited by both triptolide and dexamethasone, whereas the activity of AP-1 was not affected by either agent.	Dexamethasone	86-99	interleukin 1 beta	Homo sapiens	31-39
15840748-6	2005	IL-1beta and TNFalpha caused concentration-dependent increases in 9alpha,11beta-PGF(2) production in human amnion and choriodecidual explants.	Triamcinolone Acetonide	66-72	interleukin 1 beta	Homo sapiens	0-8
15840748-6	2005	IL-1beta and TNFalpha caused concentration-dependent increases in 9alpha,11beta-PGF(2) production in human amnion and choriodecidual explants.	11beta-pgf	73-83	interleukin 1 beta	Homo sapiens	0-8
15821150-7	2005	At higher concentrations (1-10 microM), 15d-PGJ(2) inhibited IL-1beta-stimulated PGE(2) and cytokine production and COX-2 expression, and this effect was not blocked by GW9662.	15d-pgj	40-47	interleukin 1 beta	Homo sapiens	61-69
15955209-9	2005	Therapeutic administration of sulfasalazine effectively downregulated the activation of NF-kappaB and the expression of IL-1beta mRNA and IL-8 mRNA while IkappaBalpha levels were stable.	Sulfasalazine	30-43	interleukin 1 beta	Homo sapiens	120-128
15975131-9	2005	The highest amounts of IL-1beta (10-fold) levels were determined in cell cultures exposed to copper.	Copper	93-99	interleukin 1 beta	Homo sapiens	23-31
15975131-10	2005	Indium, molybdenum and iron induced twofold IL-1beta levels compared with untreated control cultures.	Indium	0-6	interleukin 1 beta	Homo sapiens	44-52
15975131-10	2005	Indium, molybdenum and iron induced twofold IL-1beta levels compared with untreated control cultures.	Molybdenum	8-18	interleukin 1 beta	Homo sapiens	44-52
15975131-10	2005	Indium, molybdenum and iron induced twofold IL-1beta levels compared with untreated control cultures.	Iron	23-27	interleukin 1 beta	Homo sapiens	44-52
15821150-5	2005	At low concentrations (&lt;0.1 microM), 15d-PGJ(2) inhibited IL-1beta-stimulated prostaglandin E(2) (PGE(2)) but not cytokine (IL-6/IL-8) production or cyclooxygenase-2 (COX-2) expression.	15d-pgj	40-47	interleukin 1 beta	Homo sapiens	61-69
15821150-5	2005	At low concentrations (&lt;0.1 microM), 15d-PGJ(2) inhibited IL-1beta-stimulated prostaglandin E(2) (PGE(2)) but not cytokine (IL-6/IL-8) production or cyclooxygenase-2 (COX-2) expression.	Prostaglandins E	81-96	interleukin 1 beta	Homo sapiens	61-69
15821150-7	2005	At higher concentrations (1-10 microM), 15d-PGJ(2) inhibited IL-1beta-stimulated PGE(2) and cytokine production and COX-2 expression, and this effect was not blocked by GW9662.	Prostaglandins E	81-84	interleukin 1 beta	Homo sapiens	61-69
15821150-5	2005	At low concentrations (&lt;0.1 microM), 15d-PGJ(2) inhibited IL-1beta-stimulated prostaglandin E(2) (PGE(2)) but not cytokine (IL-6/IL-8) production or cyclooxygenase-2 (COX-2) expression.	Prostaglandins E	101-104	interleukin 1 beta	Homo sapiens	61-69
15821150-9	2005	The PPAR-delta ligand GW501516 also inhibited IL-1beta-stimulated PGE(2) production but only at high concentrations (1 microM).	GW 501516	22-30	interleukin 1 beta	Homo sapiens	46-54
15821150-9	2005	The PPAR-delta ligand GW501516 also inhibited IL-1beta-stimulated PGE(2) production but only at high concentrations (1 microM).	Prostaglandins E	66-69	interleukin 1 beta	Homo sapiens	46-54
15821150-10	2005	IL-1beta-induced nuclear factor-kappaB (NF-kappaB) DNA binding activity was significantly inhibited by 15d-PGJ(2) (10 microM) and GW501516 (1 microM) but increased with 10 microM rosiglitazone.	15d-pgj	103-110	interleukin 1 beta	Homo sapiens	0-8
15821150-10	2005	IL-1beta-induced nuclear factor-kappaB (NF-kappaB) DNA binding activity was significantly inhibited by 15d-PGJ(2) (10 microM) and GW501516 (1 microM) but increased with 10 microM rosiglitazone.	GW 501516	130-138	interleukin 1 beta	Homo sapiens	0-8
15821150-10	2005	IL-1beta-induced nuclear factor-kappaB (NF-kappaB) DNA binding activity was significantly inhibited by 15d-PGJ(2) (10 microM) and GW501516 (1 microM) but increased with 10 microM rosiglitazone.	Rosiglitazone	179-192	interleukin 1 beta	Homo sapiens	0-8
15989786-6	2005	CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines.	Radium	12-14	interleukin 1 beta	Homo sapiens	97-105
15904993-11	2005	Thus, minocycline might exert its antiinflammatory effect on microglia by inhibiting the expression and release of TNF-alpha, IL-1beta, and NO.	Minocycline	6-17	interleukin 1 beta	Homo sapiens	126-134
16018763-0	2005	Interleukin-1beta-induced prostaglandin E2 production by human gingival fibroblasts is upregulated by glycine.	Dinoprostone	26-42	interleukin 1 beta	Homo sapiens	0-17
16018763-0	2005	Interleukin-1beta-induced prostaglandin E2 production by human gingival fibroblasts is upregulated by glycine.	Glycine	102-109	interleukin 1 beta	Homo sapiens	0-17
16018763-5	2005	RESULTS: The PGE(2) production by IL-1beta-stimulated GFB was significantly upregulated by glycine.	Dinoprostone	13-19	interleukin 1 beta	Homo sapiens	34-42
16018763-5	2005	RESULTS: The PGE(2) production by IL-1beta-stimulated GFB was significantly upregulated by glycine.	Glycine	91-98	interleukin 1 beta	Homo sapiens	34-42
16018763-6	2005	The effect of glycine on IL- 1beta-induced cell proliferation and PGE(2) production was concentration- dependent, reached a peak at 3 mM, and declined slowly at higher doses.	Glycine	14-21	interleukin 1 beta	Homo sapiens	25-34
16018763-9	2005	The IL-1beta-driven PGE(2) synthesis was blocked by indomethacin, a COX-1/COX-2 inhibitor, and by COX-2 inhibitor NS-398.	Dinoprostone	20-26	interleukin 1 beta	Homo sapiens	4-12
16018763-9	2005	The IL-1beta-driven PGE(2) synthesis was blocked by indomethacin, a COX-1/COX-2 inhibitor, and by COX-2 inhibitor NS-398.	Indomethacin	52-64	interleukin 1 beta	Homo sapiens	4-12
16018763-9	2005	The IL-1beta-driven PGE(2) synthesis was blocked by indomethacin, a COX-1/COX-2 inhibitor, and by COX-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	114-120	interleukin 1 beta	Homo sapiens	4-12
15833737-0	2005	Interleukin-1beta differentially regulates beta2 adrenoreceptor and prostaglandin E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells.	Dinoprostone	68-84	interleukin 1 beta	Homo sapiens	0-17
15833737-0	2005	Interleukin-1beta differentially regulates beta2 adrenoreceptor and prostaglandin E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells.	Cyclic AMP	94-98	interleukin 1 beta	Homo sapiens	0-17
15833737-8	2005	Collectively, these results provide mechanistic insight into how interleukin-1beta can differentially regulate cAMP generation and chloride efflux in response to different adenylyl cyclase-coupled ligands in the same cell.	Cyclic AMP	111-115	interleukin 1 beta	Homo sapiens	65-82
15833737-0	2005	Interleukin-1beta differentially regulates beta2 adrenoreceptor and prostaglandin E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells.	Chlorides	116-124	interleukin 1 beta	Homo sapiens	0-17
15833737-8	2005	Collectively, these results provide mechanistic insight into how interleukin-1beta can differentially regulate cAMP generation and chloride efflux in response to different adenylyl cyclase-coupled ligands in the same cell.	Chlorides	131-139	interleukin 1 beta	Homo sapiens	65-82
15833737-2	2005	Here we tested the effect of interleukin-1beta, a pro-inflammatory cytokine, on cAMP accumulation and chloride efflux in Calu-3 airway epithelial cells in response to ligands binding to adenylyl cyclase-coupled receptors such as the beta2 adrenoreceptor and EP prostanoid receptors.	Cyclic AMP	80-84	interleukin 1 beta	Homo sapiens	29-46
15833737-3	2005	Interleukin-1beta significantly increased isoprenaline-induced cAMP accumulation by increasing beta2 adrenoreceptor numbers via a protein kinase A-dependent mechanism.	Isoproterenol	42-54	interleukin 1 beta	Homo sapiens	0-17
15833737-3	2005	Interleukin-1beta significantly increased isoprenaline-induced cAMP accumulation by increasing beta2 adrenoreceptor numbers via a protein kinase A-dependent mechanism.	Cyclic AMP	63-67	interleukin 1 beta	Homo sapiens	0-17
15833737-4	2005	In contrast, interleukin-1beta significantly impaired prostaglandin E2-induced cAMP accumulation by induction of cyclo-oxygenase-2, prostaglandin E2 production, and a resulting down-regulation of adenylyl cyclase.	Dinoprostone	54-70	interleukin 1 beta	Homo sapiens	13-30
15896293-2	2005	Studies suggest that P2X7 has a potentially pivotal role in inflammatory responses largely stemming from its role in mediating the release of IL-1beta in response to ATP.	Adenosine Triphosphate	166-169	interleukin 1 beta	Homo sapiens	142-150
15833737-4	2005	In contrast, interleukin-1beta significantly impaired prostaglandin E2-induced cAMP accumulation by induction of cyclo-oxygenase-2, prostaglandin E2 production, and a resulting down-regulation of adenylyl cyclase.	Cyclic AMP	79-83	interleukin 1 beta	Homo sapiens	13-30
15833737-4	2005	In contrast, interleukin-1beta significantly impaired prostaglandin E2-induced cAMP accumulation by induction of cyclo-oxygenase-2, prostaglandin E2 production, and a resulting down-regulation of adenylyl cyclase.	Dinoprostone	132-148	interleukin 1 beta	Homo sapiens	13-30
15833737-5	2005	The cAMP changes were all mirrored by alterations in chloride efflux assessed using the fluorescent chloride probe N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide with interleukin-1beta increasing chloride efflux in response to isoprenaline and reducing the response to prostaglandin E2.	Cyclic AMP	4-8	interleukin 1 beta	Homo sapiens	174-191
15833737-5	2005	The cAMP changes were all mirrored by alterations in chloride efflux assessed using the fluorescent chloride probe N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide with interleukin-1beta increasing chloride efflux in response to isoprenaline and reducing the response to prostaglandin E2.	Chlorides	53-61	interleukin 1 beta	Homo sapiens	174-191
15833737-5	2005	The cAMP changes were all mirrored by alterations in chloride efflux assessed using the fluorescent chloride probe N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide with interleukin-1beta increasing chloride efflux in response to isoprenaline and reducing the response to prostaglandin E2.	MQAE	115-168	interleukin 1 beta	Homo sapiens	174-191
15833737-5	2005	The cAMP changes were all mirrored by alterations in chloride efflux assessed using the fluorescent chloride probe N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide with interleukin-1beta increasing chloride efflux in response to isoprenaline and reducing the response to prostaglandin E2.	Chlorides	100-108	interleukin 1 beta	Homo sapiens	174-191
15833737-5	2005	The cAMP changes were all mirrored by alterations in chloride efflux assessed using the fluorescent chloride probe N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide with interleukin-1beta increasing chloride efflux in response to isoprenaline and reducing the response to prostaglandin E2.	Isoproterenol	234-246	interleukin 1 beta	Homo sapiens	174-191
15833737-5	2005	The cAMP changes were all mirrored by alterations in chloride efflux assessed using the fluorescent chloride probe N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide with interleukin-1beta increasing chloride efflux in response to isoprenaline and reducing the response to prostaglandin E2.	Dinoprostone	276-292	interleukin 1 beta	Homo sapiens	174-191
15950779-5	2005	We report that IL-1beta induced cPLA2 and COX-2 mRNA and protein expression and subsequent prostaglandin E2 (PGE2) release in a time-dependent manner in H4 neuroglioma cells.	Dinoprostone	91-107	interleukin 1 beta	Homo sapiens	15-23
21190613-0	2005	[Experimental study of effects of retinoic acid on IL-1beta and IFN-gamma induced C3 and factor B secretion in lung cancer cell line].	Tretinoin	34-47	interleukin 1 beta	Homo sapiens	51-59
21190613-2	2005	The aim of this study is to investigate the regulated effects of retinoic acid (RA) on IL-1beta and IFN-gamma induced C3 and factor B secretion in human lung cancer cell line A549.	Tretinoin	65-78	interleukin 1 beta	Homo sapiens	87-95
21190613-2	2005	The aim of this study is to investigate the regulated effects of retinoic acid (RA) on IL-1beta and IFN-gamma induced C3 and factor B secretion in human lung cancer cell line A549.	Tretinoin	80-82	interleukin 1 beta	Homo sapiens	87-95
21190613-6	2005	CONCLUSIONS: RA can up-regulate C3 and factor B secretion induced by IL-1beta and IFN-gamma in human lung cancer cell A549.	Tretinoin	13-15	interleukin 1 beta	Homo sapiens	69-77
15950779-7	2005	Similarly, in SKNSH neuroblastoma cells, both SB203580 and PD98059 reduced IL-1beta-induced PGE2 release, with no detectable COX-2 and cPLA2 protein expression in these cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	59-66	interleukin 1 beta	Homo sapiens	75-83
15950779-7	2005	Similarly, in SKNSH neuroblastoma cells, both SB203580 and PD98059 reduced IL-1beta-induced PGE2 release, with no detectable COX-2 and cPLA2 protein expression in these cells.	Dinoprostone	92-96	interleukin 1 beta	Homo sapiens	75-83
15950779-8	2005	Our results indicate that the signaling mechanisms of p38 and p42/44 MAPKs play a role in IL-1beta-mediated PGE2 release in both of these cell lines, with differences upstream at the level of cPLA(2)/COX-2 expression.	Dinoprostone	108-112	interleukin 1 beta	Homo sapiens	90-98
15950779-5	2005	We report that IL-1beta induced cPLA2 and COX-2 mRNA and protein expression and subsequent prostaglandin E2 (PGE2) release in a time-dependent manner in H4 neuroglioma cells.	Dinoprostone	109-113	interleukin 1 beta	Homo sapiens	15-23
15950779-6	2005	Both SB203580 and PD98059 [p38 and p42/44 mitogen-activated protein kinase (MAPKs) inhibitors, respectively] reduced IL-1beta-induced PGE2 production, while only SB203580 reduced both cPLA2 and COX-2 expression.	SB 203580	5-13	interleukin 1 beta	Homo sapiens	117-125
15950779-6	2005	Both SB203580 and PD98059 [p38 and p42/44 mitogen-activated protein kinase (MAPKs) inhibitors, respectively] reduced IL-1beta-induced PGE2 production, while only SB203580 reduced both cPLA2 and COX-2 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	interleukin 1 beta	Homo sapiens	117-125
15950779-6	2005	Both SB203580 and PD98059 [p38 and p42/44 mitogen-activated protein kinase (MAPKs) inhibitors, respectively] reduced IL-1beta-induced PGE2 production, while only SB203580 reduced both cPLA2 and COX-2 expression.	Dinoprostone	134-138	interleukin 1 beta	Homo sapiens	117-125
15950779-7	2005	Similarly, in SKNSH neuroblastoma cells, both SB203580 and PD98059 reduced IL-1beta-induced PGE2 release, with no detectable COX-2 and cPLA2 protein expression in these cells.	SB 203580	46-54	interleukin 1 beta	Homo sapiens	75-83
15665043-6	2005	The STAT3 inhibitor piceatannol decreased both OSM-induced VEGF release and synergy between OSM and IL-1beta, without affecting responses to IL-1beta alone.	3,3',4,5'-tetrahydroxystilbene	20-31	interleukin 1 beta	Homo sapiens	100-108
15498796-8	2005	RESULTS: Licofelone dose dependently inhibited the IL1beta stimulated production and expression of MMP-13.	licofelone	9-19	interleukin 1 beta	Homo sapiens	51-58
15905573-0	2005	Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia.	Adenosine Triphosphate	18-21	interleukin 1 beta	Homo sapiens	51-60
15943987-5	2005	Treatment of HPMC with 1 ng/ml IL-1beta (567 +/- 213 pg/10(5) cells) or TNF-alpha (89 +/- 1 pg/10(5) cells) resulted in a 13-fold (P &lt; 0.01) or 2-fold (P &lt; 0.05) elevation of the VEGF secretion.	hydroxypropylmethylcellulose-lactose matrix	13-17	interleukin 1 beta	Homo sapiens	31-39
15943987-7	2005	VEGF secretion in OVCA cells was also increased by IL-1beta (514 +/- 105 pg/10(5) cells; P &lt; 0.01) or TNF-alpha (458 +/- 168 pg/10(5) cells; P &lt; 0.01) reaching similar levels as in IL-1beta-activated HPMC.	hydroxypropylmethylcellulose-lactose matrix	206-210	interleukin 1 beta	Homo sapiens	51-59
15755849-2	2005	The expression of the prostaglandin synthetic enzyme cyclooxygenase (COX)-2 and cytokines IL-1beta and IL-8 increases within the uterus at the time of labor, and each is regulated by the transcription factor nuclear factor-kappaB (NF-kappaB).	Prostaglandins	22-35	interleukin 1 beta	Homo sapiens	90-98
15905573-8	2005	IL-1beta efflux from shed vesicles was enhanced by ATP stimulation and inhibited by pretreatment with the P2X(7) antagonist oxidized ATP, thus indicating a crucial involvement of the pore-forming P2X(7)R in the release of the cytokine.	Adenosine Triphosphate	51-54	interleukin 1 beta	Homo sapiens	0-8
15905573-8	2005	IL-1beta efflux from shed vesicles was enhanced by ATP stimulation and inhibited by pretreatment with the P2X(7) antagonist oxidized ATP, thus indicating a crucial involvement of the pore-forming P2X(7)R in the release of the cytokine.	Adenosine Triphosphate	133-136	interleukin 1 beta	Homo sapiens	0-8
15905573-9	2005	Our data identify astrocyte-derived ATP as the endogenous factor responsible for microvesicle shedding in microglia and reveal the mechanisms by which astrocyte-derived ATP triggers IL-1beta release from these cells.	Adenosine Triphosphate	169-172	interleukin 1 beta	Homo sapiens	182-190
15880353-5	2005	Moreover, to determine whether an intracellular signaling pathway mediates the IL-1beta-induced increase in sAPP(alpha) secretion, we used various specific signaling inhibitors and found that sAPP(alpha) release is significantly blocked by the mitogen-activated protein kinase (MEK1/2) inhibitor PD98059 and the c-Jun N-terminal kinase inhibitor SP600125.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	296-303	interleukin 1 beta	Homo sapiens	79-87
15905585-10	2005	More importantly, two tyrosine kinase inhibitors mimicked the effect of leflunomide in that both blocked IL-1beta-induced HAS1 activation without affecting HAS2 or HAS3.	Leflunomide	72-83	interleukin 1 beta	Homo sapiens	105-113
15880353-5	2005	Moreover, to determine whether an intracellular signaling pathway mediates the IL-1beta-induced increase in sAPP(alpha) secretion, we used various specific signaling inhibitors and found that sAPP(alpha) release is significantly blocked by the mitogen-activated protein kinase (MEK1/2) inhibitor PD98059 and the c-Jun N-terminal kinase inhibitor SP600125.	pyrazolanthrone	346-354	interleukin 1 beta	Homo sapiens	79-87
15905585-12	2005	These findings also support the concept that IL-1beta-induced HAS1 activation depends on the activation of tyrosine kinases, and indicate that leflunomide blocks HA release by suppressing tyrosine kinases rather than through inhibition of NF-kappaB translocation.	Leflunomide	143-154	interleukin 1 beta	Homo sapiens	45-53
15860218-0	2005	FK506 suppresses the stimulation of matrix metalloproteinase 13 synthesis by interleukin-1beta in rheumatoid synovial fibroblasts.	Tacrolimus	0-5	interleukin 1 beta	Homo sapiens	77-94
15934951-0	2005	Lactate induces tumour necrosis factor-alpha, interleukin-6 and interleukin-1beta release in microglial- and astroglial-enriched primary cultures.	Lactic Acid	0-7	interleukin 1 beta	Homo sapiens	64-81
15942912-5	2005	Gammalinolenic acid suppresses inflammation by acting as a competitive inhibitor of prostaglandin E2 and leukotrienes (LTs) and by reducing the auto-induction of interleukin1alpha (IL-1alpha)-induced pro-IL-1beta gene expression.	gamma-Linolenic Acid	0-19	interleukin 1 beta	Homo sapiens	200-212
15854773-0	2005	Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells.	Budesonide	0-10	interleukin 1 beta	Homo sapiens	110-118
15854773-0	2005	Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells.	BN 50730	21-29	interleukin 1 beta	Homo sapiens	110-118
15854773-0	2005	Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells.	phenyl-N-tert-butylnitrone	34-54	interleukin 1 beta	Homo sapiens	110-118
15854773-3	2005	In this study we provide data illustrating the combined effect of three independent classes of compounds: the glucocorticoid budesonide epimer R, the platelet-activating factor antagonist LAU-8080, and the free radical scavenger phenyl butyl nitrone, upon COX-2 gene activation and prostaglandin E2 (PGE2) levels in [IL-1beta+Abeta42]-stressed HN cells.	phenyl-N-tert-butylnitrone	229-249	interleukin 1 beta	Homo sapiens	317-325
15930438-7	2005	In summary, quercetin, a natural flavonol widely distributed in the human diet, inhibits NO production in IL-1beta-stimulated hepatocytes through the inhibition of iNOS expression.	Quercetin	12-21	interleukin 1 beta	Homo sapiens	106-114
15930438-7	2005	In summary, quercetin, a natural flavonol widely distributed in the human diet, inhibits NO production in IL-1beta-stimulated hepatocytes through the inhibition of iNOS expression.	3-hydroxyflavone	33-41	interleukin 1 beta	Homo sapiens	106-114
15894614-6	2005	Conjugated bile salts and the inflammatory cytokines TNF-alpha and IL-1beta were all found to increase CDX1 mRNA expression in vitro.	Bile Acids and Salts	11-21	interleukin 1 beta	Homo sapiens	67-75
15860218-4	2005	In addition, synovial fibroblasts pretreated with FK506 were stimulated with IL-1beta for 10 min and cellular lysates were subjected to anti-phospho-specific mitogen-activated protein kinase (MAPK).	Tacrolimus	50-55	interleukin 1 beta	Homo sapiens	77-85
15860218-8	2005	FK506, however, significantly suppressed MMP-13 production from IL-1beta-stimulated synovial fibroblasts.	Tacrolimus	0-5	interleukin 1 beta	Homo sapiens	64-72
15860218-9	2005	FK506 also prevented IL-1beta-stimulated JNK activation and transcriptional activation of AP-1 in these cells.	Tacrolimus	0-5	interleukin 1 beta	Homo sapiens	21-29
15796906-9	2005	From the Taqman analysis, UDP stimulation significantly upregulates the mRNA levels of IL-8, IP-10, and IL-1beta, but not TNF-alpha.	Uridine Diphosphate	26-29	interleukin 1 beta	Homo sapiens	104-112
15879116-5	2005	DMSO also elevated IL-1beta secretion by PBMC in response to exogenous superoxide anions.	Dimethyl Sulfoxide	0-4	interleukin 1 beta	Homo sapiens	19-27
15879116-5	2005	DMSO also elevated IL-1beta secretion by PBMC in response to exogenous superoxide anions.	Superoxides	71-88	interleukin 1 beta	Homo sapiens	19-27
15879116-8	2005	Cycloheximide studies demonstrated that the DMSO augmentation of IL-1beta mRNA did not require de novo protein synthesis, and studies with actinomycin D showed that DMSO did not alter the half-life of IL-1beta mRNA, suggesting that DMSO did not change the stability of IL-1beta mRNA.	Dimethyl Sulfoxide	44-48	interleukin 1 beta	Homo sapiens	65-73
15879116-9	2005	Experiments using a reporter vector containing the 5"-flanking region of the human IL-1beta gene revealed that DMSO augmented LPS-induced IL-1beta reporter activity.	Dimethyl Sulfoxide	111-115	interleukin 1 beta	Homo sapiens	83-91
15879116-9	2005	Experiments using a reporter vector containing the 5"-flanking region of the human IL-1beta gene revealed that DMSO augmented LPS-induced IL-1beta reporter activity.	Dimethyl Sulfoxide	111-115	interleukin 1 beta	Homo sapiens	138-146
15879116-11	2005	These data indicate that DMSO directly increases LPS-stimulated IL-1beta protein production through the mechanisms of augmenting promoter activity and increasing mRNA levels.	Dimethyl Sulfoxide	25-29	interleukin 1 beta	Homo sapiens	64-72
15755725-4	2005	In this study, we hypothesized that IL-1beta would decrease vectorial ion and water transport across the distal lung epithelium.	Water	78-83	interleukin 1 beta	Homo sapiens	36-44
15862289-2	2005	IL-1beta and TGFbeta induced cyclo-oxygenase (COX)-2 protein and increased prostaglandin E(2) (PGE(2)).	Dinoprostone	75-93	interleukin 1 beta	Homo sapiens	0-8
15862289-2	2005	IL-1beta and TGFbeta induced cyclo-oxygenase (COX)-2 protein and increased prostaglandin E(2) (PGE(2)).	Prostaglandins E	95-98	interleukin 1 beta	Homo sapiens	0-8
15862289-3	2005	Both IL-1beta and TGFbeta increased VEGF-A(165) mRNA and VEGF promoter luciferase construct activity, in addition VEGF-A protein was inhibited by actinomycin D suggesting transcriptional regulation.	Dactinomycin	146-159	interleukin 1 beta	Homo sapiens	5-13
15862289-4	2005	The COX inhibitors indomethacin and NS398 inhibited IL-1beta but not TGFbeta mediated VEGF-A production.	Indomethacin	19-31	interleukin 1 beta	Homo sapiens	52-60
15879116-0	2005	Mechanisms of dimethyl sulfoxide augmentation of IL-1 beta production.	Dimethyl Sulfoxide	14-32	interleukin 1 beta	Homo sapiens	49-58
15879116-3	2005	In this study, we investigated the regulatory role of the antioxidant DMSO on LPS-stimulated IL-1beta gene expression in human PBMC and in vivo.	Dimethyl Sulfoxide	70-74	interleukin 1 beta	Homo sapiens	93-101
15879116-4	2005	This study demonstrated that 1% DMSO increased LPS-stimulated (50 ng/ml) IL-1beta secretion in a dose- and time-dependent manner without altering TNF or IL-6.	Dimethyl Sulfoxide	32-36	interleukin 1 beta	Homo sapiens	73-81
15755725-7	2005	Moreover, IL-1beta decreased basal and dexamethasone-induced epithelial sodium channel alpha-subunit (alpha ENaC) mRNA levels and total and cell-surface protein expression.	Dexamethasone	39-52	interleukin 1 beta	Homo sapiens	10-18
15755725-9	2005	These results indicate that IL-1beta may contribute to alveolar edema in ALI by reducing distal lung epithelial sodium absorption.	Sodium	112-118	interleukin 1 beta	Homo sapiens	28-36
15862289-4	2005	The COX inhibitors indomethacin and NS398 inhibited IL-1beta but not TGFbeta mediated VEGF-A production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	36-41	interleukin 1 beta	Homo sapiens	52-60
15862289-6	2005	In conclusion, IL-1beta increases VEGF-A secretion by COX-2 derived PGE(2) production whereas TGFbeta uses COX-independent pathways.	Dinoprostone	68-74	interleukin 1 beta	Homo sapiens	15-23
15741158-8	2005	In addition to a marked reduction in neutrophil influx, 1 reversed increases in inflammatory mediators interleukin-1alpha, interleukin-1beta, tissue necrosis factor-alpha, and monocyte chemotactic protein-1 in the glycogen model and reversed increases in airway nitric oxide levels in the lipopolysaccharide model.	Glycogen	214-222	interleukin 1 beta	Homo sapiens	123-140
15965071-5	2005	This study was designed to evaluate the anti-inflammatory and antioxidative effects of propofol on the biosyntheses of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), IL-6, and NO in lipopolysaccharide (LPS)- activated macrophages.	Propofol	87-95	interleukin 1 beta	Homo sapiens	160-177
15677771-6	2005	SP600125, a specific c-Jun N-terminal kinase (JNK) inhibitor, inhibited the effect of IL-1beta.	pyrazolanthrone	0-8	interleukin 1 beta	Homo sapiens	86-94
15965071-7	2005	ELISA revealed that LPS increased macrophage TNF-alpha, IL-1beta, and IL-6 protein levels in a time-dependent manner, whereas propofol significantly reduced the levels of LPS-enhanced TNF-alpha, IL-1beta, and IL-6 proteins.	Propofol	126-134	interleukin 1 beta	Homo sapiens	195-203
15965071-11	2005	The present study shows that propofol, at a therapeutic concentration, has anti-inflammatory and antioxidative effects on the biosyntheses of TNF-alpha, IL-1beta, IL-6, and NO in LPS-activated macro-phages and that the suppressive effects are exerted at the pretranslational level.	Propofol	29-37	interleukin 1 beta	Homo sapiens	153-161
15838249-5	2005	A potential role for prostaglandin E2 in downregulating interleukin-1beta-induced inflammatory responses has also been described.	Dinoprostone	21-37	interleukin 1 beta	Homo sapiens	56-73
15494434-6	2005	sPLA2 alone and in cooperation with TNF-alpha and interleukin 1 beta (IL-1beta) induced fatty acid release from DC membranes, which was accompanied by upregulation of surface markers and by an increase in the migratory and immunostimulatory capacity of the DCs.	Fatty Acids	88-98	interleukin 1 beta	Homo sapiens	50-68
15494434-6	2005	sPLA2 alone and in cooperation with TNF-alpha and interleukin 1 beta (IL-1beta) induced fatty acid release from DC membranes, which was accompanied by upregulation of surface markers and by an increase in the migratory and immunostimulatory capacity of the DCs.	Fatty Acids	88-98	interleukin 1 beta	Homo sapiens	70-78
15820487-0	2005	Valsartan reduces interleukin-1beta secretion by peripheral blood mononuclear cells in patients with essential hypertension.	Valsartan	0-9	interleukin 1 beta	Homo sapiens	18-35
15820487-4	2005	In this study, we investigated whether treatment with valsartan, an angiotensin receptor blocker, lowered IL-1beta secretion by PBMCs in patients with essential hypertension.	Valsartan	54-63	interleukin 1 beta	Homo sapiens	106-114
15820487-8	2005	RESULTS: Compared with routine therapy group, patients treated with valsartan had decreased secretion of IL-1beta in PBMCs after stimulated by lipopolysaccharide (2857+/-643 vs. 2146+/-508 pg/ml, P&lt;0.05).	Valsartan	68-77	interleukin 1 beta	Homo sapiens	105-113
15985720-3	2005	The aim of our study was to assess the effect of fenofibrate, a commonly used hypolipidemic drug, on the release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1) by monocytes from patients with combined hyperlipidemia.	Fenofibrate	49-60	interleukin 1 beta	Homo sapiens	116-133
15840779-2	2005	In this study, we have determined the effects of calcium and thrombin on the release of EGF, TGF-alpha, IGF-1, Ang-2 and IL-1beta from PRPs, and assessed the mitogenic potential of PRP supernatants on osteoblast and endothelial cell division.	Calcium	49-56	interleukin 1 beta	Homo sapiens	121-129
15701708-7	2005	In addition, AGIX-4207 inhibited cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-alpha, IL-1beta, and IL-6 from human peripheral blood mononuclear cells.	camobucol	13-22	interleukin 1 beta	Homo sapiens	247-255
15868626-12	2005	Peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-delta(12,14)-prostaglandin J2 and troglitazone, inhibited IL-1beta-induced mPGES-1 protein expression, an effect that was reversed by exogenous PGE2.	15-deoxy-delta(12,14)-prostaglandin J2	58-96	interleukin 1 beta	Homo sapiens	125-133
15868626-12	2005	Peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-delta(12,14)-prostaglandin J2 and troglitazone, inhibited IL-1beta-induced mPGES-1 protein expression, an effect that was reversed by exogenous PGE2.	Troglitazone	101-113	interleukin 1 beta	Homo sapiens	125-133
15868626-12	2005	Peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-delta(12,14)-prostaglandin J2 and troglitazone, inhibited IL-1beta-induced mPGES-1 protein expression, an effect that was reversed by exogenous PGE2.	Dinoprostone	211-215	interleukin 1 beta	Homo sapiens	125-133
15985724-0	2005	Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages.	Apigenin	10-18	interleukin 1 beta	Homo sapiens	68-85
15985724-0	2005	Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages.	kaempferol	20-30	interleukin 1 beta	Homo sapiens	68-85
15985724-0	2005	Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages.	Resveratrol	35-46	interleukin 1 beta	Homo sapiens	68-85
15985720-3	2005	The aim of our study was to assess the effect of fenofibrate, a commonly used hypolipidemic drug, on the release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1) by monocytes from patients with combined hyperlipidemia.	Fenofibrate	49-60	interleukin 1 beta	Homo sapiens	135-143
15985724-2	2005	Apigenin, kaempferol and resveratrol present in fruits, vegetables and grain were investigated for their effect on the synthesis of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) at transcriptional level in lipopolysaccharide (LPS)-stimulated J774.2 macrophages.	kaempferol	10-20	interleukin 1 beta	Homo sapiens	151-159
15985720-10	2005	Thirty-day fenofibrate treatment decreased the release of IL-1beta by 43% (143.9 +/- 6.5 vs. 86.2 +/- 5.9 pg/ml), of IL-6 by 22% (8212 +/- 285 vs. 6330 +/- 234 pg/ml), and of MCP-1 by 29% (19.6 +/- 0.9 vs. 14.0 +/- 0.8 ng/ml).	Fenofibrate	11-22	interleukin 1 beta	Homo sapiens	58-66
15985724-2	2005	Apigenin, kaempferol and resveratrol present in fruits, vegetables and grain were investigated for their effect on the synthesis of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) at transcriptional level in lipopolysaccharide (LPS)-stimulated J774.2 macrophages.	Resveratrol	25-36	interleukin 1 beta	Homo sapiens	132-149
15985724-2	2005	Apigenin, kaempferol and resveratrol present in fruits, vegetables and grain were investigated for their effect on the synthesis of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) at transcriptional level in lipopolysaccharide (LPS)-stimulated J774.2 macrophages.	Resveratrol	25-36	interleukin 1 beta	Homo sapiens	151-159
15705740-7	2005	Here, we have used an in vitro model of cyclo-oxygenase-2 activity (A549 cells stimulated with IL-1beta) to show that acetaminophen is an effective inhibitor of cyclo-oxygenase activity in intact cells.	Acetaminophen	118-131	interleukin 1 beta	Homo sapiens	95-103
15985724-4	2005	Apigenin and kaempferol caused inhibition of IL-1beta gene expression in J774.2 macrophages, but resveratrol was ineffective.	kaempferol	13-23	interleukin 1 beta	Homo sapiens	45-53
15877961-6	2005	CONCLUSION: Aloe polysaccharide could promote keratinocytes to secrete TGF-alpha, TGF-beta1, IL-1beta, IL-6, IL-8 and TNF, and inhibit the release of NO.	aloe polysaccharide	12-31	interleukin 1 beta	Homo sapiens	93-101
15811372-7	2005	The native ensemble of IL-1beta was characterized using a variety of experimental probes under native (0 M NaCl, guanidine hydrochloride (Gdn-HCl)), moderately destabilized (0 M NaCl, 0.8 M Gdn-HCl), and in moderate salt concentration (0.8 M NaCl, 0 M Gdn-HCl).	Sodium Chloride	107-111	interleukin 1 beta	Homo sapiens	23-31
15811372-7	2005	The native ensemble of IL-1beta was characterized using a variety of experimental probes under native (0 M NaCl, guanidine hydrochloride (Gdn-HCl)), moderately destabilized (0 M NaCl, 0.8 M Gdn-HCl), and in moderate salt concentration (0.8 M NaCl, 0 M Gdn-HCl).	Guanidine	113-136	interleukin 1 beta	Homo sapiens	23-31
15811372-7	2005	The native ensemble of IL-1beta was characterized using a variety of experimental probes under native (0 M NaCl, guanidine hydrochloride (Gdn-HCl)), moderately destabilized (0 M NaCl, 0.8 M Gdn-HCl), and in moderate salt concentration (0.8 M NaCl, 0 M Gdn-HCl).	Guanidine	138-145	interleukin 1 beta	Homo sapiens	23-31
15811372-7	2005	The native ensemble of IL-1beta was characterized using a variety of experimental probes under native (0 M NaCl, guanidine hydrochloride (Gdn-HCl)), moderately destabilized (0 M NaCl, 0.8 M Gdn-HCl), and in moderate salt concentration (0.8 M NaCl, 0 M Gdn-HCl).	Guanidine	190-197	interleukin 1 beta	Homo sapiens	23-31
15811372-7	2005	The native ensemble of IL-1beta was characterized using a variety of experimental probes under native (0 M NaCl, guanidine hydrochloride (Gdn-HCl)), moderately destabilized (0 M NaCl, 0.8 M Gdn-HCl), and in moderate salt concentration (0.8 M NaCl, 0 M Gdn-HCl).	Guanidine	190-197	interleukin 1 beta	Homo sapiens	23-31
15833866-12	2005	Validation is confirmed for several specific genes that may influence radiosensitization by erlotinib including Egr-1, CXCL1, and IL-1beta.	Erlotinib Hydrochloride	92-101	interleukin 1 beta	Homo sapiens	130-138
15550558-15	2005	The data suggest that, in esophagitis, IL-1beta causes production of H(2)O(2).	Hydrogen Peroxide	69-77	interleukin 1 beta	Homo sapiens	39-47
15550563-8	2005	Mutagenesis analyses mapped an IL-1beta response element to a previously identified bile acid response element, which contains an HNF4alpha binding site.	Bile Acids and Salts	84-93	interleukin 1 beta	Homo sapiens	31-39
16011257-10	2005	Ginkgolide B at concentration of 1 x 10(-5) to 1 x 10(-8) mol x L(-1) could also reduce both the IL-1beta and TNF-alpha contents in the supernatants of U937 cell culture stimulated by PMA, but the scopes of changes were much different.	ginkgolide B	0-12	interleukin 1 beta	Homo sapiens	97-105
15812237-4	2005	NaBu was sufficient to induce SAA2 expression after transient treatment with IL-1beta and, conversely, IL-1beta induced SAA2 after transient treatment with NaBu.	sethoxydim	0-4	interleukin 1 beta	Homo sapiens	77-85
15812237-4	2005	NaBu was sufficient to induce SAA2 expression after transient treatment with IL-1beta and, conversely, IL-1beta induced SAA2 after transient treatment with NaBu.	sethoxydim	156-160	interleukin 1 beta	Homo sapiens	103-111
15812750-8	2005	Both treatments induced a significant decrease in the levels of cytokines (for all P &lt; .01), but the decrease in TNF-alpha and IL-1beta was more consistent in the carvedilol group ( P &lt; .01).	Carvedilol	166-176	interleukin 1 beta	Homo sapiens	130-138
15801029-9	2005	Under these conditions, naproxen treatment induced a higher level of IL-1beta production.	Naproxen	24-32	interleukin 1 beta	Homo sapiens	69-77
15801029-0	2005	Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.	Leukotrienes	0-11	interleukin 1 beta	Homo sapiens	110-127
15801029-0	2005	Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.	Prostaglandins	16-29	interleukin 1 beta	Homo sapiens	110-127
15755670-9	2005	The excessive production of cytokines, such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, was significantly abolished by triptolide administration.	triptolide	140-150	interleukin 1 beta	Homo sapiens	85-107
16011257-12	2005	Furthermore, ginkgolide B at concentrations of 1 x 10(-5) to 1 x 10(-7) mol x L(-1) was shown to significantly inhibit TNF-alpha mRNA expression of U937 cells; and at concentrations of 1 x 10(-5) and 1 x 10(-6) mol x L(-1) could inhibit IL-1beta mRNA expression.	ginkgolide B	13-25	interleukin 1 beta	Homo sapiens	237-245
16146335-4	2005	Thalidomide and IMiDs inhibit the cytokines tumor necrosis factor-alpha (TNF-alpha), interleukins (IL) 1beta, 6, 12, and granulocyte macrophage-colony stimulating factor (GM-CSF).	Thalidomide	0-11	interleukin 1 beta	Homo sapiens	85-108
15664665-4	2005	The stimulatory effect of BK on the IL-1beta- or TNFalpha-stimulated IL-8 production was reduced in the presence of BK B2 receptor antagonist HOE 140, whereas the B1 receptor antagonist Lys-(des-arg9, Leu8)-BK had no effect.	Lysine	186-190	interleukin 1 beta	Homo sapiens	36-44
15664665-4	2005	The stimulatory effect of BK on the IL-1beta- or TNFalpha-stimulated IL-8 production was reduced in the presence of BK B2 receptor antagonist HOE 140, whereas the B1 receptor antagonist Lys-(des-arg9, Leu8)-BK had no effect.	des-arg9	191-199	interleukin 1 beta	Homo sapiens	36-44
15664665-5	2005	Similar to BK, the calcium ionophore A23187 also upregulated the stimulatory effect of IL-1beta and TNFalpha on IL-8 production.	Calcium	19-26	interleukin 1 beta	Homo sapiens	87-95
15664665-5	2005	Similar to BK, the calcium ionophore A23187 also upregulated the stimulatory effect of IL-1beta and TNFalpha on IL-8 production.	Calcimycin	37-43	interleukin 1 beta	Homo sapiens	87-95
16146335-4	2005	Thalidomide and IMiDs inhibit the cytokines tumor necrosis factor-alpha (TNF-alpha), interleukins (IL) 1beta, 6, 12, and granulocyte macrophage-colony stimulating factor (GM-CSF).	imids	16-21	interleukin 1 beta	Homo sapiens	85-108
15664665-6	2005	The protein kinase C (PKC) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone.	bisindolylmaleimide	37-56	interleukin 1 beta	Homo sapiens	117-125
15664665-6	2005	The protein kinase C (PKC) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone.	Bismuth	58-61	interleukin 1 beta	Homo sapiens	117-125
15664665-7	2005	The specific p38 mitogen-activated protein kinase (MAPK) inhibitor SB 203580 reduced IL-8 production stimulated by the combination of BK and IL-1beta as well as the IL-1beta-stimulated IL-8 production.	SB 203580	67-76	interleukin 1 beta	Homo sapiens	141-149
15792794-1	2005	Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta.	Polycyclic Aromatic Hydrocarbons	0-32	interleukin 1 beta	Homo sapiens	171-179
15792794-1	2005	Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta.	Polycyclic Aromatic Hydrocarbons	34-38	interleukin 1 beta	Homo sapiens	171-179
15792794-1	2005	Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta.	Benzo(a)pyrene	48-62	interleukin 1 beta	Homo sapiens	171-179
15792794-1	2005	Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta.	Benzo(a)pyrene	64-66	interleukin 1 beta	Homo sapiens	171-179
15707402-5	2005	Our present study has demonstrated that inhibition of the p38 pathway by a chemical p38 inhibitor, SB203580, suppresses IL-1beta and TNF-alpha production in human islets exposed to lipopolysaccharide (LPS) and/or inflammatory cytokines.	SB 203580	99-107	interleukin 1 beta	Homo sapiens	120-128
15669081-3	2005	The mRNA expression of tumor necrosis factor-alpha and interleukin-1beta was significantly higher when macrophages were coincubated with beads made with nonpurified compared with purified alginate (p&lt;0.01, p&lt;0.05, respectively) and negative control (p&lt;0.001) or with APA microcapsules compared with non-PLL-coated alginate beads and negative control (p&lt;0.001).	Alginates	188-196	interleukin 1 beta	Homo sapiens	55-72
15669081-3	2005	The mRNA expression of tumor necrosis factor-alpha and interleukin-1beta was significantly higher when macrophages were coincubated with beads made with nonpurified compared with purified alginate (p&lt;0.01, p&lt;0.05, respectively) and negative control (p&lt;0.001) or with APA microcapsules compared with non-PLL-coated alginate beads and negative control (p&lt;0.001).	apa	276-279	interleukin 1 beta	Homo sapiens	55-72
15669081-3	2005	The mRNA expression of tumor necrosis factor-alpha and interleukin-1beta was significantly higher when macrophages were coincubated with beads made with nonpurified compared with purified alginate (p&lt;0.01, p&lt;0.05, respectively) and negative control (p&lt;0.001) or with APA microcapsules compared with non-PLL-coated alginate beads and negative control (p&lt;0.001).	Alginates	323-331	interleukin 1 beta	Homo sapiens	55-72
15744069-5	2005	The oridonin-augmented phagocytosis was attenuated by anti-human TNFalpha and IL-1beta antisera, suggesting that TNFalpha and IL-1beta participate in the phagocytosis by oridonin-treated U937 cell-derived macrophages.	oridonin	4-12	interleukin 1 beta	Homo sapiens	78-86
15744069-5	2005	The oridonin-augmented phagocytosis was attenuated by anti-human TNFalpha and IL-1beta antisera, suggesting that TNFalpha and IL-1beta participate in the phagocytosis by oridonin-treated U937 cell-derived macrophages.	oridonin	4-12	interleukin 1 beta	Homo sapiens	126-134
15744069-5	2005	The oridonin-augmented phagocytosis was attenuated by anti-human TNFalpha and IL-1beta antisera, suggesting that TNFalpha and IL-1beta participate in the phagocytosis by oridonin-treated U937 cell-derived macrophages.	oridonin	170-178	interleukin 1 beta	Homo sapiens	126-134
15744069-7	2005	Taken together, oridonin facilitates the phagocytic activity against apoptotic cells through TNFalpha and IL-1beta release, which may be contribute to its antitumor activities.	oridonin	16-24	interleukin 1 beta	Homo sapiens	106-114
15514971-3	2005	SB 203580 and rapamycin reversed the RNA stabilization effect of IL-1beta in a dose-dependent manner, suggesting involvement of the p38/MAP kinase and mTOR pathways.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	65-73
15816458-1	2005	BACKGROUND/AIMS: The possibility that interleukin-1 beta (IL-1beta) is a neuromodulator of the non-adrenergic non-cholinergic (NANC) inhibitory nerves which may be mediated by nitric oxide (NO) was recently reported from animal experiments.	Nitric Oxide	176-188	interleukin 1 beta	Homo sapiens	38-56
15816458-1	2005	BACKGROUND/AIMS: The possibility that interleukin-1 beta (IL-1beta) is a neuromodulator of the non-adrenergic non-cholinergic (NANC) inhibitory nerves which may be mediated by nitric oxide (NO) was recently reported from animal experiments.	Nitric Oxide	176-188	interleukin 1 beta	Homo sapiens	58-66
15816458-8	2005	Both tetrodotoxin and L-NNA inhibited the relaxation reaction in response to IL-1beta in the human colon.	Tetrodotoxin	5-17	interleukin 1 beta	Homo sapiens	77-85
15816458-8	2005	Both tetrodotoxin and L-NNA inhibited the relaxation reaction in response to IL-1beta in the human colon.	Nitroarginine	22-27	interleukin 1 beta	Homo sapiens	77-85
15699791-5	2005	The generation of oxidants by silica particles and by silica-activated cells results in cell and lung damage; increased expression of inflammatory cytokines, including TNF-alpha, IL 1 beta, and TGF-beta; activation of cell signaling pathways, including the MAP kinase pathways; and phosphorylation and activation of specific transcription factors (e.g., NFkB).	Silicon Dioxide	30-36	interleukin 1 beta	Homo sapiens	179-188
15699791-5	2005	The generation of oxidants by silica particles and by silica-activated cells results in cell and lung damage; increased expression of inflammatory cytokines, including TNF-alpha, IL 1 beta, and TGF-beta; activation of cell signaling pathways, including the MAP kinase pathways; and phosphorylation and activation of specific transcription factors (e.g., NFkB).	Silicon Dioxide	54-60	interleukin 1 beta	Homo sapiens	179-188
15578659-11	2005	Being associated together with chloride conductance, P2X7 receptors and ABC1 transporters delineate a subtle and complex regulation of IL-1beta production in mammalian Schwann cells.	Chlorides	31-39	interleukin 1 beta	Homo sapiens	135-143
15514971-3	2005	SB 203580 and rapamycin reversed the RNA stabilization effect of IL-1beta in a dose-dependent manner, suggesting involvement of the p38/MAP kinase and mTOR pathways.	Sirolimus	14-23	interleukin 1 beta	Homo sapiens	65-73
15659543-4	2005	RESULTS: Stimulation with the cytokines interleukin-1beta(IL-1beta)/interferon-gamma (IFN-gamma) increased NO up to 3.3-fold and moxifloxacin inhibited this up to 68% (P &lt; 0.05).	Moxifloxacin	129-141	interleukin 1 beta	Homo sapiens	40-57
15659543-4	2005	RESULTS: Stimulation with the cytokines interleukin-1beta(IL-1beta)/interferon-gamma (IFN-gamma) increased NO up to 3.3-fold and moxifloxacin inhibited this up to 68% (P &lt; 0.05).	Moxifloxacin	129-141	interleukin 1 beta	Homo sapiens	58-66
15710472-5	2005	In addition, stimulation of phosphoinositide hydrolysis by the selective group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG) was reduced after exposure to interleukin 1beta.	Phosphatidylinositols	28-44	interleukin 1 beta	Homo sapiens	157-174
15725942-4	2005	Cultured human aortic vascular smooth muscle cells (HASMC) were stimulated for 18 hours with 10 ng/mL interleukin-1beta (IL-1beta), resulting in a marked increase of iNOS levels and NO production, as determined by Western blotting and nitrite measurement, respectively.	Nitrites	235-242	interleukin 1 beta	Homo sapiens	102-119
15725942-4	2005	Cultured human aortic vascular smooth muscle cells (HASMC) were stimulated for 18 hours with 10 ng/mL interleukin-1beta (IL-1beta), resulting in a marked increase of iNOS levels and NO production, as determined by Western blotting and nitrite measurement, respectively.	Nitrites	235-242	interleukin 1 beta	Homo sapiens	121-129
15725942-8	2005	In conclusion, sodium azide from the commercial CRP solution, but not CRP itself, mainly accounts for the inhibitory effect on IL-1beta-evoked iNOS induction and NO release.	Sodium Azide	15-27	interleukin 1 beta	Homo sapiens	127-135
15728522-6	2005	IL-1beta activates the ERK 1/2 pathway in these fibroblasts and interrupting this signaling either with PD98059, a chemical inhibitor of MEK, or by transfecting cells with a dominant negative ERK 1 plasmid results in the attenuation of TIMP-1 induction.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	104-111	interleukin 1 beta	Homo sapiens	0-8
15710472-5	2005	In addition, stimulation of phosphoinositide hydrolysis by the selective group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG) was reduced after exposure to interleukin 1beta.	3,5-dihydroxyphenylglycine	89-119	interleukin 1 beta	Homo sapiens	157-174
15710472-5	2005	In addition, stimulation of phosphoinositide hydrolysis by the selective group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG) was reduced after exposure to interleukin 1beta.	3,5-dihydroxyphenylglycine	121-125	interleukin 1 beta	Homo sapiens	157-174
25048558-0	2005	Topical ALA-PDT modifies neutrophils" chemiluminescence, lymphocytes" interleukin-1beta secretion and serum level of transforming growth factor beta1 in patients with nonmelanoma skin malignancies A clinical study.	Aminolevulinic Acid	8-11	interleukin 1 beta	Homo sapiens	70-87
15652647-0	2005	Radioprotection by N-palmitoylated nonapeptide of human interleukin-1beta.	Nitrogen	19-20	interleukin 1 beta	Homo sapiens	56-73
15563545-9	2005	Interferon-gamma/IL-1beta pretreatment sensitizes human thyroid cells to Fas-mediated apoptosis in a complex manner that overcomes this blockade through increased expression of cell surface Fas receptor, increases in proapoptotic molecules that result in mitochondrial activation, and late caspase cleavage.	ammonium ferrous sulfate	73-76	interleukin 1 beta	Homo sapiens	17-25
15652448-5	2005	Further, IL-1beta stimulated HGF to produce IL-6, IL-8, PGE(2) and MMP-1 via activation of the 3 MAPKs and NF-kappaB, as inhibitors of each MAPK and NF-kappaB significantly suppressed the production of IL-1beta-stimulated factors, though these pathways might also play distinct roles in IL-1beta activities.	Prostaglandins E	56-59	interleukin 1 beta	Homo sapiens	9-17
15733769-9	2005	TNF-alpha, IL-1beta, and reactive oxygen species (ROS) tended to be lower in the NAC-group (NS).	Acetylcysteine	81-84	interleukin 1 beta	Homo sapiens	11-19
15710762-9	2005	Hippocampal neurons after global ischemia were more preserved, and the terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick end labeling-positive cells were diminished by the IL-10 gene transfer with attenuated IL-1beta and augmented tissue necrosis factor-alpha.	dutp-biotin	118-129	interleukin 1 beta	Homo sapiens	230-238
15652448-6	2005	Our results strongly suggest that the MAPKs/AP-1 and IKK/IkappaB/NF-kappaB cascades cooperatively mediate the IL-1beta-stimulated synthesis of IL-6, IL-8, PGE(2) and MMP-1 in HGF.	Prostaglandins E	155-158	interleukin 1 beta	Homo sapiens	110-118
15629451-10	2005	IL-1beta plus IFN-gamma-induced synergistic production of HGF was potently inhibited by treatment of cells with the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059 and the p38 inhibitor SB203580 but not by the c-Jun N-terminal kinase (JNK) inhibitor SP600125.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	177-184	interleukin 1 beta	Homo sapiens	0-8
15733557-3	2005	Lansoprazole reduced supernatant titers and RNA of rhinovirus, the susceptibility to rhinovirus infection, the ICAM-1 mRNA production, the number and fluorescence intensity of acidic endosomes in the cells, and supernatants sICAM-1 and cytokine concentrations including interleukin-1beta.	Lansoprazole	0-12	interleukin 1 beta	Homo sapiens	270-287
15733557-5	2005	These results suggest that lansoprazole inhibits rhinovirus infection by reducing ICAM-1 via partly endogenous production of interleukin-1beta, and by blocking the rhinovirus RNA entry into the endosomes.	Lansoprazole	27-39	interleukin 1 beta	Homo sapiens	125-142
15613280-4	2005	These changes are blocked by the MEK1/2 specific inhibitor U0126, indicating that MEK1/2 is essential for IL-1beta signaling in TT cells.	U 0126	59-64	interleukin 1 beta	Homo sapiens	106-114
15629451-10	2005	IL-1beta plus IFN-gamma-induced synergistic production of HGF was potently inhibited by treatment of cells with the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059 and the p38 inhibitor SB203580 but not by the c-Jun N-terminal kinase (JNK) inhibitor SP600125.	SB 203580	207-215	interleukin 1 beta	Homo sapiens	0-8
15629451-10	2005	IL-1beta plus IFN-gamma-induced synergistic production of HGF was potently inhibited by treatment of cells with the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059 and the p38 inhibitor SB203580 but not by the c-Jun N-terminal kinase (JNK) inhibitor SP600125.	pyrazolanthrone	271-279	interleukin 1 beta	Homo sapiens	0-8
15685372-5	2005	IL-1beta stimulated the formation of NO and PGE2 by pancreatic beta-cells.	Dinoprostone	44-48	interleukin 1 beta	Homo sapiens	0-8
15685372-6	2005	L-NMMA completely inhibited IL-1beta-induced NO formation and attenuated PGE2 production.	omega-N-Methylarginine	0-6	interleukin 1 beta	Homo sapiens	28-36
15458923-3	2005	Thus we examined IL-1beta-stimulated mPGES-1 and cPGES mRNA and protein expression in gastric fibroblasts by quantitative PCR and Western blot analysis, respectively, and studied both their relationship to COX-1 and -2 and their roles in PGE2 and VEGF production in vitro.	Dinoprostone	238-242	interleukin 1 beta	Homo sapiens	17-25
15685372-8	2005	L-NMMA inhibited IL-1beta-induced promoter activity, gene transcription and protein expression of COX-2 in pancreatic beta-cells.	omega-N-Methylarginine	0-6	interleukin 1 beta	Homo sapiens	17-25
15454397-7	2005	At further variance with insulin, GABA release from living beta-cells depends little on its cellular content but increases with IL-1beta-induced alterations in beta-cell phenotype.	gamma-Aminobutyric Acid	34-38	interleukin 1 beta	Homo sapiens	128-136
15715567-4	2005	RESULTS: The most significant changes were detected in the levels of MMP-3 mRNA in control cells (2.4-fold increase), of TIMP-1 and -2 mRNA in cells treated with Il-1beta (2.6-fold increase) and of MMP-3 mRNA in cells treated with Dex (3.5-fold increase) exposed to 50 mmHg pressure.	Dexamethasone	231-234	interleukin 1 beta	Homo sapiens	162-170
15458923-10	2005	These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway.	mapeg	297-302	interleukin 1 beta	Homo sapiens	156-164
15458923-7	2005	However, MK-886 did inhibit IL-1beta-stimulated PGES activity in vitro by 86.8%.	MK-886	9-15	interleukin 1 beta	Homo sapiens	28-36
15458923-10	2005	These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway.	Dinoprostone	391-395	interleukin 1 beta	Homo sapiens	27-35
15458923-10	2005	These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway.	Dinoprostone	391-395	interleukin 1 beta	Homo sapiens	156-164
15458923-10	2005	These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway.	Dinoprostone	131-135	interleukin 1 beta	Homo sapiens	27-35
15458923-10	2005	These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway.	Eicosanoids	258-268	interleukin 1 beta	Homo sapiens	27-35
15458923-10	2005	These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway.	Eicosanoids	258-268	interleukin 1 beta	Homo sapiens	156-164
15458923-10	2005	These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway.	Glutathione	273-284	interleukin 1 beta	Homo sapiens	27-35
15458923-10	2005	These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway.	Glutathione	273-284	interleukin 1 beta	Homo sapiens	156-164
15458923-10	2005	These results suggest that IL-1beta-induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that IL-1beta-stimulated VEGF production was totally dependent on membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway.	mapeg	297-302	interleukin 1 beta	Homo sapiens	27-35
15489374-4	2005	Consistently, IL-1beta-stimulated phosphorylation of p42/p44 MAPK, p38, and JNK was attenuated by pretreatment with U0126, SB-202190, or SP-600125, respectively.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	123-132	interleukin 1 beta	Homo sapiens	14-22
15489374-4	2005	Consistently, IL-1beta-stimulated phosphorylation of p42/p44 MAPK, p38, and JNK was attenuated by pretreatment with U0126, SB-202190, or SP-600125, respectively.	pyrazolanthrone	137-146	interleukin 1 beta	Homo sapiens	14-22
15489374-3	2005	IL-1beta induced expression of VCAM-1 protein and mRNA in a time-dependent manner, which was significantly inhibited by inhibitors of MEK1/2 (U0126 and PD-98059), p38 (SB-202190), and c-Jun NH(2)-terminal kinase (JNK; SP-600125).	U 0126	142-147	interleukin 1 beta	Homo sapiens	0-8
15489374-3	2005	IL-1beta induced expression of VCAM-1 protein and mRNA in a time-dependent manner, which was significantly inhibited by inhibitors of MEK1/2 (U0126 and PD-98059), p38 (SB-202190), and c-Jun NH(2)-terminal kinase (JNK; SP-600125).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	152-160	interleukin 1 beta	Homo sapiens	0-8
15489374-3	2005	IL-1beta induced expression of VCAM-1 protein and mRNA in a time-dependent manner, which was significantly inhibited by inhibitors of MEK1/2 (U0126 and PD-98059), p38 (SB-202190), and c-Jun NH(2)-terminal kinase (JNK; SP-600125).	pyrazolanthrone	218-227	interleukin 1 beta	Homo sapiens	0-8
15489374-5	2005	IL-1beta-induced VCAM-1 expression was significantly blocked by the specific NF-kappaB inhibitors helenalin and pyrrolidine dithiocarbamate.	helenalin	98-107	interleukin 1 beta	Homo sapiens	0-8
15640521-4	2005	IL-1beta promoted the elaboration of G-CSF, which was augmented by PGE(2).	Prostaglandins E	67-70	interleukin 1 beta	Homo sapiens	0-8
15489374-5	2005	IL-1beta-induced VCAM-1 expression was significantly blocked by the specific NF-kappaB inhibitors helenalin and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	112-139	interleukin 1 beta	Homo sapiens	0-8
15489374-6	2005	As expected, IL-1beta-stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha were blocked by helenalin but not by U0126, SB-202190, or SP-600125.	helenalin	126-135	interleukin 1 beta	Homo sapiens	13-21
15489374-7	2005	Moreover, the resultant enhancement of VCAM-1 expression increased the adhesion of polymorphonuclear cells to a monolayer of HTSMC, which was blocked by pretreatment with helenalin, U0126, SB-202190, or SP-600125 before IL-1beta exposure or by anti-VCAM-1 antibody.	helenalin	171-180	interleukin 1 beta	Homo sapiens	220-228
15673867-0	2005	Activated endothelial interleukin-1beta, -6, and -8 concentrations and intercellular adhesion molecule-1 expression are attenuated by lidocaine.	Lidocaine	134-143	interleukin 1 beta	Homo sapiens	22-51
15489374-4	2005	Consistently, IL-1beta-stimulated phosphorylation of p42/p44 MAPK, p38, and JNK was attenuated by pretreatment with U0126, SB-202190, or SP-600125, respectively.	U 0126	116-121	interleukin 1 beta	Homo sapiens	14-22
15673867-6	2005	Lidocaine (0.5 mg/mL) decreased IL-1beta (1.89 +/- 0.11 versus 4.16 +/- 1.27 pg/mL; P = 0.009), IL-6 (65.5 +/- 5.14 versus 162 +/- 11.5 pg/mL; P &lt; 0.001), and IL-8 (3869 +/- 785 versus 14,961 +/- 406 pg/mL; P &lt; 0.001) concentrations compared with the control.	Lidocaine	0-9	interleukin 1 beta	Homo sapiens	32-40
15673867-9	2005	Activated endothelial IL-1beta, IL-6, and IL-8 concentrations and ICAM-1 expression are attenuated only by lidocaine at concentrations larger than clinically relevant concentrations.	Lidocaine	107-116	interleukin 1 beta	Homo sapiens	22-30
15677503-2	2005	Under in vitro conditions, interleukin-1beta (IL-1beta) + gamma-interferon (IFN-gamma) induce nitric oxide (NO) production and apoptosis in rodent and human pancreatic beta-cells.	Nitric Oxide	94-106	interleukin 1 beta	Homo sapiens	27-44
15677503-2	2005	Under in vitro conditions, interleukin-1beta (IL-1beta) + gamma-interferon (IFN-gamma) induce nitric oxide (NO) production and apoptosis in rodent and human pancreatic beta-cells.	Nitric Oxide	94-106	interleukin 1 beta	Homo sapiens	46-54
15389584-5	2005	The IL-1beta induction of ICAM-1 mRNA and protein were partially inhibited by U0126 and PD98059 (specific inhibitors of MEK1/2) and SP600125 [a specific inhibitor of c-Jun-N-terminal kinase (JNK)].	U 0126	78-83	interleukin 1 beta	Homo sapiens	4-12
15389584-5	2005	The IL-1beta induction of ICAM-1 mRNA and protein were partially inhibited by U0126 and PD98059 (specific inhibitors of MEK1/2) and SP600125 [a specific inhibitor of c-Jun-N-terminal kinase (JNK)].	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	88-95	interleukin 1 beta	Homo sapiens	4-12
15389584-5	2005	The IL-1beta induction of ICAM-1 mRNA and protein were partially inhibited by U0126 and PD98059 (specific inhibitors of MEK1/2) and SP600125 [a specific inhibitor of c-Jun-N-terminal kinase (JNK)].	pyrazolanthrone	132-140	interleukin 1 beta	Homo sapiens	4-12
15389584-6	2005	U0126 was more potent than other inhibitors to attenuate IL-1beta-induced ICAM-1 expression.	U 0126	0-5	interleukin 1 beta	Homo sapiens	57-65
15389584-7	2005	Consistently, IL-1beta stimulated phosphorylation of p42/p44 MAPK and JNK which was attenuated by pretreatment with U0126 or SP600125, respectively.	U 0126	116-121	interleukin 1 beta	Homo sapiens	14-22
15389584-7	2005	Consistently, IL-1beta stimulated phosphorylation of p42/p44 MAPK and JNK which was attenuated by pretreatment with U0126 or SP600125, respectively.	pyrazolanthrone	125-133	interleukin 1 beta	Homo sapiens	14-22
15654265-10	2005	We have observed significant reduction of IL-1beta mRNA expression after 30-day treatment with the examined drugs (atorvastatin, 2.10 +/- 0.50 versus 1.05 +/- 0.15; P &lt; 0.001, fenofibrate; 2.27 +/- 0.48 versus 1.23 +/- 0.27; P &lt; 0.01).	Atorvastatin	115-127	interleukin 1 beta	Homo sapiens	42-50
15389584-9	2005	The combination of PD98059 and SP600125 displayed an additive effect on IL-1beta-induced ICAM-1 gene expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	19-26	interleukin 1 beta	Homo sapiens	72-80
15654265-10	2005	We have observed significant reduction of IL-1beta mRNA expression after 30-day treatment with the examined drugs (atorvastatin, 2.10 +/- 0.50 versus 1.05 +/- 0.15; P &lt; 0.001, fenofibrate; 2.27 +/- 0.48 versus 1.23 +/- 0.27; P &lt; 0.01).	Fenofibrate	179-190	interleukin 1 beta	Homo sapiens	42-50
15389584-9	2005	The combination of PD98059 and SP600125 displayed an additive effect on IL-1beta-induced ICAM-1 gene expression.	pyrazolanthrone	31-39	interleukin 1 beta	Homo sapiens	72-80
15389584-10	2005	IL-1beta-induced ICAM-1 expression was almost completely blocked by a specific NF-kappaB inhibitor helenalin.	helenalin	99-108	interleukin 1 beta	Homo sapiens	0-8
15389584-11	2005	Consistently, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha which was blocked by helenalin, U0126, or SP600125.	helenalin	132-141	interleukin 1 beta	Homo sapiens	14-22
15389584-11	2005	Consistently, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha which was blocked by helenalin, U0126, or SP600125.	U 0126	143-148	interleukin 1 beta	Homo sapiens	14-22
15389584-11	2005	Consistently, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha which was blocked by helenalin, U0126, or SP600125.	pyrazolanthrone	153-161	interleukin 1 beta	Homo sapiens	14-22
15705185-4	2005	RESULTS: Interleukin-1beta-treated PTC exhibited time-dependent increases in fibronectin secretion (ELISA), cell injury (LDH release) and reactive nitrogen species (RNS) release (Griess assay).	Reactive Nitrogen Species	138-163	interleukin 1 beta	Homo sapiens	9-26
15671209-5	2005	To the same extent as for TNF-alpha, phloretin also inhibited IL-1beta-induced upregulation in expression of all 3 adhesion molecules.	Phloretin	37-46	interleukin 1 beta	Homo sapiens	62-70
15652404-2	2005	Abeta(1-42) (5 microM) applied for 8 h induced the expression and increased the production of the pro-inflammatory cytokines IL-6, IL-1beta, TNF-alpha, the inducible enzyme COX-2 and chemokine IL-8.	UNII-042A8N37WH	0-5	interleukin 1 beta	Homo sapiens	131-139
15613075-14	2005	CONCLUSIONS: In this 18-week clinical trial, the results suggested that scaling/root planing with adjunctive subgingival administration of minocycline ointment has a significantly better and prolonged effect compared to scaling/root planing alone on the reduction of probing depth, clinical attachment loss, gingival index, and interleukin-1beta content, but not on bleeding on probing.	Minocycline	139-150	interleukin 1 beta	Homo sapiens	328-345
15528403-3	2005	Here, we report the effect of a variety of E- and Falpha-ring 8-isoprostanes on the release of granulocyte/macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) from human airway smooth muscle (HASM) cells stimulated with interleukin-1beta (IL-1beta).	e- and falpha-ring 8-isoprostanes	43-76	interleukin 1 beta	Homo sapiens	264-281
15528403-3	2005	Here, we report the effect of a variety of E- and Falpha-ring 8-isoprostanes on the release of granulocyte/macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) from human airway smooth muscle (HASM) cells stimulated with interleukin-1beta (IL-1beta).	e- and falpha-ring 8-isoprostanes	43-76	interleukin 1 beta	Homo sapiens	283-291
15528403-4	2005	The elaboration of GM-CSF and G-CSF by IL-1beta was inhibited and augmented, respectively, in a concentration-dependent manner by 8-iso-prostaglandin (PG) E(1) and 8-iso-PGE(2), but not by 8-iso-PGF(1alpha), 8-iso-PGF(2alpha), and 8-iso-PGF(3)alpha.	8-iso-prostaglandin	130-149	interleukin 1 beta	Homo sapiens	39-47
15528403-4	2005	The elaboration of GM-CSF and G-CSF by IL-1beta was inhibited and augmented, respectively, in a concentration-dependent manner by 8-iso-prostaglandin (PG) E(1) and 8-iso-PGE(2), but not by 8-iso-PGF(1alpha), 8-iso-PGF(2alpha), and 8-iso-PGF(3)alpha.	8-iso-pge	164-173	interleukin 1 beta	Homo sapiens	39-47
15528403-4	2005	The elaboration of GM-CSF and G-CSF by IL-1beta was inhibited and augmented, respectively, in a concentration-dependent manner by 8-iso-prostaglandin (PG) E(1) and 8-iso-PGE(2), but not by 8-iso-PGF(1alpha), 8-iso-PGF(2alpha), and 8-iso-PGF(3)alpha.	8-iso-pgf	189-198	interleukin 1 beta	Homo sapiens	39-47
15528403-4	2005	The elaboration of GM-CSF and G-CSF by IL-1beta was inhibited and augmented, respectively, in a concentration-dependent manner by 8-iso-prostaglandin (PG) E(1) and 8-iso-PGE(2), but not by 8-iso-PGF(1alpha), 8-iso-PGF(2alpha), and 8-iso-PGF(3)alpha.	8-iso-pgf	208-217	interleukin 1 beta	Homo sapiens	39-47
15528403-4	2005	The elaboration of GM-CSF and G-CSF by IL-1beta was inhibited and augmented, respectively, in a concentration-dependent manner by 8-iso-prostaglandin (PG) E(1) and 8-iso-PGE(2), but not by 8-iso-PGF(1alpha), 8-iso-PGF(2alpha), and 8-iso-PGF(3)alpha.	8-iso-pgf	208-217	interleukin 1 beta	Homo sapiens	39-47
15612946-5	2005	The effect of cycloheximide, a protein synthesis inhibitor, on the IL-1beta-induced expression of RIG-I was examined.	Cycloheximide	14-27	interleukin 1 beta	Homo sapiens	67-75
15705185-4	2005	RESULTS: Interleukin-1beta-treated PTC exhibited time-dependent increases in fibronectin secretion (ELISA), cell injury (LDH release) and reactive nitrogen species (RNS) release (Griess assay).	Reactive Nitrogen Species	165-168	interleukin 1 beta	Homo sapiens	9-26
15705185-6	2005	The effects of IL-1beta, which were reproduced by incubation of PTC with PMA (6.25-100 nmol/L), were blocked by H7 but not by BIM-1.	Tetradecanoylphorbol Acetate	73-76	interleukin 1 beta	Homo sapiens	15-23
15390091-0	2005	Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes.	Cannabinoids	10-21	interleukin 1 beta	Homo sapiens	83-91
15390091-6	2005	In this study, we investigated the effects of the synthetic cannabinoid WIN55,212-2 on the production of several key inflammatory mediators by human fetal astrocytes activated by IL-1beta.	Cannabinoids	60-71	interleukin 1 beta	Homo sapiens	179-187
15390091-6	2005	In this study, we investigated the effects of the synthetic cannabinoid WIN55,212-2 on the production of several key inflammatory mediators by human fetal astrocytes activated by IL-1beta.	win55	72-77	interleukin 1 beta	Homo sapiens	179-187
15516334-5	2005	The treatment of epidermal cells with the PPAR gamma-specific agonist ciglitazone or azPC augmented cyclooxygenase-2 expression and enzyme activity induced by phorbol 12-myristate-13-acetate or interleukin-1 beta.	ciglitazone	70-81	interleukin 1 beta	Homo sapiens	194-212
15516334-5	2005	The treatment of epidermal cells with the PPAR gamma-specific agonist ciglitazone or azPC augmented cyclooxygenase-2 expression and enzyme activity induced by phorbol 12-myristate-13-acetate or interleukin-1 beta.	azpc	85-89	interleukin 1 beta	Homo sapiens	194-212
15622543-3	2005	We hypothesized that two caspase-1-processed cytokines, interleukin (IL)-1beta and IL-18, are involved in oxygen-induced neuronal cell death.	Oxygen	106-112	interleukin 1 beta	Homo sapiens	56-78
15472991-5	2005	We now show that, following treatment with the proinflammatory cytokine IL-1beta, BzATP induces a robust rise in [Ca2+]i with agonist and antagonist profiles indicative of the P2X7R.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	82-87	interleukin 1 beta	Homo sapiens	72-80
15472991-6	2005	IL-1beta also induced the formation of membrane pores as evidenced by the uptake of YO-PRO-1 (375 Da).	YO-PRO 1	84-92	interleukin 1 beta	Homo sapiens	0-8
16132613-9	2005	As the leukocytes-endothelial adhesive interactions also play an important role in inflammation, we found that sinomenine reduced the transmigration of granulocytic differentiated HL60 cells across IL-1beta activated HUVEC monolayer.	sinomenine	111-121	interleukin 1 beta	Homo sapiens	198-206
15675987-9	2005	Patients in the physostigmine group also exhibited reduced ex-vivo production of the proinflammatory cytokine, IL-1beta.	Physostigmine	16-29	interleukin 1 beta	Homo sapiens	111-119
15675987-11	2005	CONCLUSIONS: Physostigmine combined with morphine in the postoperative period reduced morphine consumption, enhanced analgesia, and attenuated production of the proinflammatory cytokine, IL-1beta.	Physostigmine	13-26	interleukin 1 beta	Homo sapiens	187-195
15675987-11	2005	CONCLUSIONS: Physostigmine combined with morphine in the postoperative period reduced morphine consumption, enhanced analgesia, and attenuated production of the proinflammatory cytokine, IL-1beta.	Morphine	41-49	interleukin 1 beta	Homo sapiens	187-195
15652830-8	2005	RESULTS: IL-1beta tear concentrations increased significantly in both groups, compared with baseline values, during preserved timolol therapy.	Timolol	126-133	interleukin 1 beta	Homo sapiens	9-17
15652830-11	2005	CONCLUSION: The use of preservatives in timolol 0.5% eyedrops leads to tear film instability and ocular surface inflammatory changes documented by a reduction of breakup time and an increase of IL-1beta tear concentrations.	Timolol	40-47	interleukin 1 beta	Homo sapiens	194-202
16277680-4	2005	Recently, we reported that tumour necrosis factor (TNF)-alpha, IL-1alpha, IL-1beta and IL-17 enhance Cyp7b mRNA expression and induce a concomitant increase in the formation of 7alpha-OH-DHEA by fibroblast-like synoviocytes (FLS) from rheumatoid arthritis patients.	7-hydroxydehydroepiandrosterone	177-191	interleukin 1 beta	Homo sapiens	74-82
16207333-6	2005	Using pharmacological and cytokine inhibitors, we observed that OCP crystals induced NO production and inducible NOS mRNA activation were regulated at both the transcriptional and the translational levels; were independent from IL-1beta gene activation; and involved p38 and c-Jun amino-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathways, as further confirmed by OCP crystal-induced p38 and JNK MAPK phosphorylation.	octacalcium phosphate	64-67	interleukin 1 beta	Homo sapiens	228-236
15987479-3	2005	MMP-3 and MMP-13 gene expression induced by IL-1beta, TNF-alpha and IL-17 was downregulated by mithramycin in human chondrosarcoma SW1353 cells and in primary human and bovine femoral head chondrocytes.	Plicamycin	95-106	interleukin 1 beta	Homo sapiens	44-52
16129959-5	2005	As extracellular levels of ATP rise, the P2X7 receptor undergoes a change in permeability, which leads to the onset of apoptotic events and the release of IL-1beta.	Adenosine Triphosphate	27-30	interleukin 1 beta	Homo sapiens	155-163
15641079-9	2005	IL-1beta-induced histone H3 acetylation was selectively blocked by 15d-PGJ(2).	15d-pgj	67-74	interleukin 1 beta	Homo sapiens	0-8
15641079-12	2005	Furthermore, 15d-PGJ(2) blocked IL-1beta-induced recruitment of p300 to the COX-2 promoter, which may be the mechanism for decreased histone H3 acetylation and COX-2 expression.	15d-pgj	13-20	interleukin 1 beta	Homo sapiens	32-40
15641079-14	2005	CONCLUSION: These data suggest that 15d-PGJ(2) can inhibit IL-1beta-induced COX-2 expression by an HDAC-independent mechanism, probably by interfering with HAT p300.	15d-pgj	36-43	interleukin 1 beta	Homo sapiens	59-67
15627743-12	2005	Compared to basal levels, quantitation of TNF-alpha and IL-1beta mRNA revealed a 15- and 9-fold increase, respectively, in samples exposed to Hemophan for 180 min.	Hemophan	142-150	interleukin 1 beta	Homo sapiens	56-64
15641079-0	2005	Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism.	14-prostaglandin j2	118-137	interleukin 1 beta	Homo sapiens	14-31
15641079-3	2005	We undertook this study to investigate the effects of 15d-PGJ(2) on interleukin-1beta (IL-1beta)-induced COX-2 expression in human synovial fibroblasts (HSFs).	15d-pgj	54-61	interleukin 1 beta	Homo sapiens	68-85
15641079-3	2005	We undertook this study to investigate the effects of 15d-PGJ(2) on interleukin-1beta (IL-1beta)-induced COX-2 expression in human synovial fibroblasts (HSFs).	15d-pgj	54-61	interleukin 1 beta	Homo sapiens	87-95
15459112-7	2005	Treatment of human islets with a combination of IL-1beta and IFN-gamma (IL-1beta+IFN-gamma), for 48 h and 5 d, resulted in an increase of NO production and the impairment of glucose-stimulated insulin secretion, respectively.	Glucose	174-181	interleukin 1 beta	Homo sapiens	48-56
15929608-6	2005	Thus, the aim of the present study was to analyze the effect of CS and HA (500-730 kDa) on MMP-3 synthesis induced by interleukin-1beta (IL-1beta) in chondrocytes from patients with hip OA.	Chondroitin Sulfates	64-66	interleukin 1 beta	Homo sapiens	118-135
15929608-6	2005	Thus, the aim of the present study was to analyze the effect of CS and HA (500-730 kDa) on MMP-3 synthesis induced by interleukin-1beta (IL-1beta) in chondrocytes from patients with hip OA.	Chondroitin Sulfates	64-66	interleukin 1 beta	Homo sapiens	137-145
15929608-8	2005	The results revealed that both CS and HA (500-730 kDa) inhibited MMP-3 synthesis induced by IL-1beta in human OA chondrocytes.	Chondroitin Sulfates	31-33	interleukin 1 beta	Homo sapiens	92-100
15619239-5	2005	Moreover, the production of prostaglandin E2 was partially controlled by interleukin-1beta and tumor necrosis factor alpha.	Dinoprostone	28-44	interleukin 1 beta	Homo sapiens	73-122
14963719-5	2005	In both NS and betamethasone patients, the levels of IL-1beta and IL-8 had significantly decreased by the 3rd and 2nd weeks after therapy, respectively.	Betamethasone	15-28	interleukin 1 beta	Homo sapiens	53-61
15597323-5	2005	Similarly, sialic acid (CD33 ligand) removal from the monocyte surface by neuraminidase resulted in IL-1 beta up-regulation, while the addition of red blood cells or sialyllactosamine (but not lactosamine) reversed the effect of neuraminidase treatment, thus demonstrating the importance of ligand recognition by CD33 for repression of monocyte activation.	N-Acetylneuraminic Acid	11-22	interleukin 1 beta	Homo sapiens	100-109
15589507-7	2005	Among studied inflammatory genes, induction of IL-1beta and MCP-1 was potentiated in animals injected with EtOH plus Tat.	Ethanol	107-111	interleukin 1 beta	Homo sapiens	47-55
16435581-2	2005	When added to HGFs, IL-1beta had a stimulatory effect on the production of IL-6, and this effect was significantly reduced by SB203580, a specific p38 MAPK inhibitor.	SB 203580	126-134	interleukin 1 beta	Homo sapiens	20-28
15723199-2	2005	In this study, oligonucleotide microarrays were used to identify novel transcriptional events mediated by TNF alpha and IL-1 beta.	Oligonucleotides	15-30	interleukin 1 beta	Homo sapiens	120-129
16435585-5	2005	The amount of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 in PBMC culture supernatant was significantly increased in the lipopolysaccaride (LPS)- or desferrioxamine (DFX)-treated cells compared with unstimulated cells.	lipopolysaccaride	162-179	interleukin 1 beta	Homo sapiens	74-82
15665553-5	2005	Both SP600125, a specific inhibitor of JNK, and SB203580, a specific inhibitor of p38 MAPK, suppressed the IL-1beta-induced expression of alpha-SMA and cell migration, but these effects were not observed with PD98059, a specific inhibitor of ERK.	SB 203580	48-56	interleukin 1 beta	Homo sapiens	107-115
15830921-1	2005	UNLABELLED: All-trans-retinoic acid (tRA) modulates in human mesangial cells (MC) antioxidant defenses, the expression of interleukin-1beta-induced vascular cell-adhesion molecule-1 (VCAM-1), cyclooxygenase-2 (COX-2), and the retinoic acid-receptor-beta (RAR-beta).	Tretinoin	12-35	interleukin 1 beta	Homo sapiens	122-139
15830921-1	2005	UNLABELLED: All-trans-retinoic acid (tRA) modulates in human mesangial cells (MC) antioxidant defenses, the expression of interleukin-1beta-induced vascular cell-adhesion molecule-1 (VCAM-1), cyclooxygenase-2 (COX-2), and the retinoic acid-receptor-beta (RAR-beta).	Tretinoin	37-40	interleukin 1 beta	Homo sapiens	122-139
15483103-6	2005	Induction of COX-2 promoter activity by IL-1beta is mediated via MAPK-dependent phosphorylation of cAMP-responding element binding protein.	Cyclic AMP	99-103	interleukin 1 beta	Homo sapiens	40-48
15483103-7	2005	Promoter activity and EMSAs demonstrate that a cAMP response element site located at -571/-564 of COX-2 promoter is critical for IL-1beta-induced COX-2 gene expression.	Cyclic AMP	47-51	interleukin 1 beta	Homo sapiens	129-137
15615881-7	2005	Consistently, dexamethasone and the MC supernatant inhibited the production of IL-1beta, TNF-alpha, and MIP-2 by macrophages.	Dexamethasone	14-27	interleukin 1 beta	Homo sapiens	79-87
14628144-6	2005	TNF-alpha and IL-1beta mRNA expression is decreased by PD-098059 after stimulation with LPS but not with porins in differentiated U937 cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	55-64	interleukin 1 beta	Homo sapiens	14-22
15665553-5	2005	Both SP600125, a specific inhibitor of JNK, and SB203580, a specific inhibitor of p38 MAPK, suppressed the IL-1beta-induced expression of alpha-SMA and cell migration, but these effects were not observed with PD98059, a specific inhibitor of ERK.	pyrazolanthrone	5-13	interleukin 1 beta	Homo sapiens	107-115
16122880-3	2005	Gallium III can inhibit the production of inflammatory cytokines, such as IL-1beta, produced by macrophage-like cells in vitro.	gallium iii	0-11	interleukin 1 beta	Homo sapiens	74-82
16122880-4	2005	A dose-dependent inhibition of IL-1beta and TPA stimulated MMP activity by gallium nitrate at increasing concentrations occurs, demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis.	gallium nitrate	75-90	interleukin 1 beta	Homo sapiens	31-39
16122880-4	2005	A dose-dependent inhibition of IL-1beta and TPA stimulated MMP activity by gallium nitrate at increasing concentrations occurs, demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis.	gallium nitrate	147-162	interleukin 1 beta	Homo sapiens	31-39
16137184-0	2005	Use of duplex PCR-CTPP methods for CYP2E1RsaI/IL-2 T-330G and IL-1B C-31T/TNF-A T-1031C polymorphisms.	ctpp	18-22	interleukin 1 beta	Homo sapiens	62-67
16137184-1	2005	BACKGROUND: Two duplex polymerase chain reaction (PCR) with confronting two-pair primer (PCR-CTPP) methods were designed for cytochrome P450 (CYP) 2E1 RsaI and interleukin (IL-2) T-330G, and for IL-1B C-31T and tumor necrosis factor-alpha (TNF-A) T-1031C.	ctpp	93-97	interleukin 1 beta	Homo sapiens	195-200
15665553-5	2005	Both SP600125, a specific inhibitor of JNK, and SB203580, a specific inhibitor of p38 MAPK, suppressed the IL-1beta-induced expression of alpha-SMA and cell migration, but these effects were not observed with PD98059, a specific inhibitor of ERK.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	209-216	interleukin 1 beta	Homo sapiens	107-115
15621371-8	2005	IL-1beta and TNFalpha treatment for 24 h enhanced prostaglandin E2 (PGE2) production 2-4-fold, which was blocked by pretreatment with the COX-2 inhibitor, NS-398.	Dinoprostone	50-66	interleukin 1 beta	Homo sapiens	0-8
17822279-4	2005	DHMEQ inhibited TNF-alpha-, IL-1beta-, and LPS-induced NF-kappaB activation in HUVEC.	dehydroxymethylepoxyquinomicin	0-5	interleukin 1 beta	Homo sapiens	28-36
15621371-8	2005	IL-1beta and TNFalpha treatment for 24 h enhanced prostaglandin E2 (PGE2) production 2-4-fold, which was blocked by pretreatment with the COX-2 inhibitor, NS-398.	Dinoprostone	68-72	interleukin 1 beta	Homo sapiens	0-8
15621371-8	2005	IL-1beta and TNFalpha treatment for 24 h enhanced prostaglandin E2 (PGE2) production 2-4-fold, which was blocked by pretreatment with the COX-2 inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	155-161	interleukin 1 beta	Homo sapiens	0-8
15621371-10	2005	These results indicate that TNFalpha and IL-1beta induce the functional expression of COX-2 but not EP receptors in DRG cells in culture and suggest that cytokine-induced sensitization of sensory neurons is secondary to prostaglandin production and not alterations in EP receptors.	Prostaglandins	220-233	interleukin 1 beta	Homo sapiens	41-49
17405308-6	2005	For both groups of investigated subjects, the levels of TNF-alpha and IL-1beta in the supernatants of whole blood culture stimulated with CS were significantly higher than in unstimulated cultures, although lower than in LPS-stimulated samples.	cantastim	138-140	interleukin 1 beta	Homo sapiens	70-78
15939312-7	2005	Fluticasone propionate was able to suppress IL-1beta induced IL-8 protein and promoter activation, using both a -1481 bp fragment and a -133 bp fragment, indicating that the glucocorticoid response element found at -330 bp was not required for fluticasone mediated suppression of IL-8 promoter activation.	Fluticasone	0-22	interleukin 1 beta	Homo sapiens	44-52
15939312-7	2005	Fluticasone propionate was able to suppress IL-1beta induced IL-8 protein and promoter activation, using both a -1481 bp fragment and a -133 bp fragment, indicating that the glucocorticoid response element found at -330 bp was not required for fluticasone mediated suppression of IL-8 promoter activation.	Fluticasone	244-255	interleukin 1 beta	Homo sapiens	44-52
16107015-3	2005	The sphingomyelin pathway of IL-1beta signal transduction is one of the principle signal mechanisms providing realization of most, if not all, biological effects of cytokine.	Sphingomyelins	4-17	interleukin 1 beta	Homo sapiens	29-37
16107015-5	2005	It has been established that IL-1beta operation in the CNS involves mechanisms mediated by IL-1 type beta1 receptor and the shingomyeline pathway of cytokine signal transduction into the cell.	shingomyeline	124-137	interleukin 1 beta	Homo sapiens	29-37
15485876-5	2004	IL-1 beta up-regulated GCLC expression (10 ng/ml IL-1 beta, 3.76 +/- 0.86; 100 ng/ml IL-1 beta, 4.22 +/- 0.68-fold control) via the p38 form of mitogen-activated protein kinase and NF kappa B and also increased reactive oxygen species levels (10 ng/ml IL-1 beta, 5.41 +/- 1.8-fold control).	Reactive Oxygen Species	211-234	interleukin 1 beta	Homo sapiens	0-9
15485876-8	2004	IL-1 beta significantly decreased glucose-stimulated insulin secretion (control, 123.8 +/- 17.7; IL-1 beta, 40.2 +/- 3.9 microunits/ml insulin/islet).	Glucose	34-41	interleukin 1 beta	Homo sapiens	0-9
15485876-8	2004	IL-1 beta significantly decreased glucose-stimulated insulin secretion (control, 123.8 +/- 17.7; IL-1 beta, 40.2 +/- 3.9 microunits/ml insulin/islet).	Glucose	34-41	interleukin 1 beta	Homo sapiens	97-106
15485876-9	2004	GCLC overexpression increased intraislet GSH levels and partially prevented the decrease in glucose-stimulated insulin secretion caused by IL-1 beta.	Glucose	92-99	interleukin 1 beta	Homo sapiens	139-148
15541342-7	2004	Pretreatment of cells with IL-1beta suppressed the phosphorylation of cAMP-responsive element-binding protein induced by cholera toxin but not that induced by 8-bromo-cAMP.	Cyclic AMP	70-74	interleukin 1 beta	Homo sapiens	27-35
15541342-4	2004	IL-1alpha, IL-1beta, and TNF-alpha alone had minimal stimulating effects on HGF production in human dermal fibroblasts, but they strongly inhibited production of HGF induced by cholera toxin, 8-bromo-cAMP, EGF, and phorbol 12-myristate 13-acetate (PMA).	8-Bromo Cyclic Adenosine Monophosphate	192-204	interleukin 1 beta	Homo sapiens	11-19
15471850-4	2004	In this study, we have shown that treatment of rat islets with IL-1beta or human islets with a cytokine mixture containing IL-1beta + IFN-gamma +/- TNF-alpha stimulates COX-2 expression and PGE(2) formation in a time-dependent manner.	Prostaglandins E	190-193	interleukin 1 beta	Homo sapiens	123-131
15753145-8	2004	alpha-Tocopherol therapy, especially at high doses, has been shown to decrease release of pro-inflammatory cytokines (such as interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha) and the chemokine interleukin-8, and to decrease adhesion of monocytes to endothelium.	alpha-Tocopherol	0-16	interleukin 1 beta	Homo sapiens	126-143
15454119-0	2004	Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-alpha, IL-1beta.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	120-128
15454119-7	2004	The results showed TNF-alpha, IL-1beta could reach the peak with 0.06mM nicotine treated for 24 and 12 h on Ana-1, respectively, but IL-8 and IFN-gamma had no significant alter.	Nicotine	72-80	interleukin 1 beta	Homo sapiens	30-38
15454119-11	2004	In conclusion, our findings suggest that nicotine could augment macrophages releasing TNF-alpha and IL-1beta, furthermore TNF-alpha and IL-1beta could up-regulate the expression of adhesion molecule and increase adhesion of monocytes to HUVECs.	Nicotine	41-49	interleukin 1 beta	Homo sapiens	100-108
15271650-6	2004	IL-1beta and IL-6 reduced contraction in response to EFS (2-10 Hz, 0.2 ms) but did not affect ACh-induced contraction, suggesting that these cytokines inhibit ACh release without affecting myogenic contractile mechanisms.	Acetylcholine	159-162	interleukin 1 beta	Homo sapiens	0-8
15271650-7	2004	EFS-induced ACh release was significantly reduced in normal esophageal strips by incubation in IL-1beta or IL-6, suggesting that they may contribute to the contractility changes.	Acetylcholine	12-15	interleukin 1 beta	Homo sapiens	95-103
15271650-10	2004	The data suggest that the proinflammatory cytokines IL-1beta and IL-6 contribute to reduced esophageal contraction by inhibiting release of ACh from myenteric neurons.	Acetylcholine	140-143	interleukin 1 beta	Homo sapiens	52-60
15659840-0	2004	Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.	Curcumin	11-19	interleukin 1 beta	Homo sapiens	78-95
15659840-0	2004	Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.	Curcumin	21-38	interleukin 1 beta	Homo sapiens	78-95
15659840-3	2004	Therefore, the aim of this study was to determine whether curcumin modifies the catabolic response of chondrocytes to IL-1beta.	Curcumin	58-66	interleukin 1 beta	Homo sapiens	118-126
15659840-8	2004	In addition, IL-1beta-induced a decrease in type II collagen, which was relieved by curcumin treatment.	Curcumin	84-92	interleukin 1 beta	Homo sapiens	13-21
15659840-9	2004	In response to IL-1beta, NF-kappaB translocated to the nucleus, but translocation was inhibited by curcumin, as revealed by immunofluorescence microscopy.	Curcumin	99-107	interleukin 1 beta	Homo sapiens	15-23
15659840-11	2004	Curcumin protected chondrocytes from the catabolic effects of IL-1beta, such as MMP-3 upregulation, and interestingly also relieved cytokine-induced suppression of matrix protein synthesis.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	62-70
15328158-3	2004	We previously demonstrated the ability of K-7174 (a GATA-specific inhibitor), when injected intraperitoneally, to improve Epo production that had been inhibited by IL-1beta or TNF-alpha treatment.	K 7174	42-48	interleukin 1 beta	Homo sapiens	164-172
15328158-5	2004	Oral administration of K-11706 reversed the decreases in hemoglobin and serum Epo concentrations, reticulocyte counts, and numbers of erythroid colony-forming units (CFU-Es) induced by IL-1beta or TNF-alpha.	k-11706	23-30	interleukin 1 beta	Homo sapiens	185-193
15507306-6	2004	Administration of pINA, however, did correlate with decreased IL1B secretion by cultured, unstimulated PBMC but had no effect on their ability to release IFNG.	pina	18-22	interleukin 1 beta	Homo sapiens	62-66
15566301-2	2004	Systematic optimization of the imidazole N-1 substituent resulted in compound 9b that potently inhibited the mitogen-activated protein kinase p38 (p38 IC(50) = 0.218 microM) as well as the release of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) from human whole blood after stimulation with LPS.	imidazole	31-40	interleukin 1 beta	Homo sapiens	230-248
15566301-2	2004	Systematic optimization of the imidazole N-1 substituent resulted in compound 9b that potently inhibited the mitogen-activated protein kinase p38 (p38 IC(50) = 0.218 microM) as well as the release of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) from human whole blood after stimulation with LPS.	imidazole	31-40	interleukin 1 beta	Homo sapiens	250-259
15321787-3	2004	We investigated FKN expression by human ASMC in response to the proinflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma, the T helper 2-type cytokines IL-4, IL-10, and IL-13, and the fibrogenic cytokine transforming growth factor (TGF)-beta.	asmc	40-44	interleukin 1 beta	Homo sapiens	90-98
15659840-12	2004	Therefore, curcumin antagonizes crucial catabolic effects of IL-1beta signaling that are known to contribute to the pathogenesis of osteoarthritis.	Curcumin	11-19	interleukin 1 beta	Homo sapiens	61-69
15329330-3	2004	It was previously demonstrated that EGF could potentiate IL-1beta-driven PGE(2) production in amnion and amnion-derived (WISH) cells.	Prostaglandins E	73-76	interleukin 1 beta	Homo sapiens	57-65
15329330-8	2004	The 26 S proteasome inhibitor, MG-132, selectively abrogated IL-1beta-driven NFkappaB activation and COX-2 mRNA expression.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	31-37	interleukin 1 beta	Homo sapiens	61-69
15526270-9	2004	In contrast, all river-water samples triggered secretion of proinflammatory cytokines, as shown for TNF-alpha, IL-1beta, and IL-6.	Water	23-28	interleukin 1 beta	Homo sapiens	111-119
15504750-3	2004	Moreover, ritonavir can suppress activation of the transcription factor nuclear factor-kappaB and is an inhibitor of interleukin-1beta and tumor necrosis factor-alpha production in peripheral blood mononuclear cells.	Ritonavir	10-19	interleukin 1 beta	Homo sapiens	117-166
15579413-3	2004	AMs isolated after intratracheal instillation of silica up-regulated mRNA levels of four additional genes [granulocyte/macrophage-colony stimulating factor (GM-CSF), IL-1beta, IL-10, and inducible nitric oxide synthase].	Silicon Dioxide	49-55	interleukin 1 beta	Homo sapiens	166-174
15591036-7	2004	Stimulation of cytokines (interleukin-1 beta, tumour necrosis factor-alpha, interferon-gamma) induced iNOS promoter activity in all conditions and this was accompanied by an increase in nitric oxide (NO) production.	Nitric Oxide	186-198	interleukin 1 beta	Homo sapiens	26-74
15719860-11	2004	Endothelial supernatant IL-1beta concentrations in lidocaine-treated HUVECs were similar to controls.	Lidocaine	51-60	interleukin 1 beta	Homo sapiens	24-32
15530883-8	2004	Furthermore, NO donors and 8-Br-cGMP could also reverse the increased permeability of the monolayers induced by IL-1beta, IFN-gamma, and LPS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	27-36	interleukin 1 beta	Homo sapiens	112-120
15813471-11	2004	CONCLUSIONS: Choriodecidual plasma from blood stimulated with GBS is enriched with biochemical signals that enhance the MMP-9, IL-1beta and TNF-alpha production by amniochorion.	gbs	62-65	interleukin 1 beta	Homo sapiens	127-135
15732864-8	2004	The frequency of IL-1B -511 A1/A2 heterozygote was significantly increased in male GAgP group compared to male controls (adjusted OR 3.16, 95% CI: 1.01 to 9.89, P = 0.048).	gagp	83-87	interleukin 1 beta	Homo sapiens	17-22
15569263-6	2004	Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	76-84
15596224-13	2004	Crystal violet staining and Matrigel invasion revealed a higher invasion index following IL-1beta challenge and a low invasion index following TGF-beta1 challenge.	Gentian Violet	0-14	interleukin 1 beta	Homo sapiens	89-97
15496611-6	2004	IL-1 beta, IL-6, IL-8 and TNF-alpha were significantly associated with lactate/choline in the DGN (p = 0.03, 0.02, 0.03, and 0.01 respectively), but not in the WS (all p &gt; 0.1).	Lactic Acid	71-78	interleukin 1 beta	Homo sapiens	0-9
15571984-3	2004	Furthermore, we found that interleukin-1 (IL-1)beta, glutamate, hydrogen peroxide (H2O2), and sodium nitroprusside (SNP) induced the expression of mRNA for occludin and GULT1 under normoxic condition.	Hydrogen Peroxide	64-81	interleukin 1 beta	Homo sapiens	42-51
15571984-3	2004	Furthermore, we found that interleukin-1 (IL-1)beta, glutamate, hydrogen peroxide (H2O2), and sodium nitroprusside (SNP) induced the expression of mRNA for occludin and GULT1 under normoxic condition.	Hydrogen Peroxide	83-87	interleukin 1 beta	Homo sapiens	42-51
15569326-8	2004	After lipopolysaccaride stimulation, monocyte production of IL-1beta, TNF-alpha, and IL-6 in ARF patients was reduced by 41%, 84%, and 45%, respectively, compared to healthy subjects (P &lt; 0.01 in each case), and similarly reduced compared to CKD and ESRD patients, and were similar to CRIT ILL patients.	lipopolysaccaride	6-23	interleukin 1 beta	Homo sapiens	60-68
15663638-10	2004	Significant positive correlations were found between malondialdehyde and interleukin-1beta, interleukin-6, leptin and lipoprotein (a) (P &lt;0.05).	Malondialdehyde	53-68	interleukin 1 beta	Homo sapiens	73-90
15496611-6	2004	IL-1 beta, IL-6, IL-8 and TNF-alpha were significantly associated with lactate/choline in the DGN (p = 0.03, 0.02, 0.03, and 0.01 respectively), but not in the WS (all p &gt; 0.1).	Choline	79-86	interleukin 1 beta	Homo sapiens	0-9
15491790-5	2004	injection of 12.5 ng of IL-1beta caused significant changes in plasma corticosterone, as compared to basal levels.	Corticosterone	70-84	interleukin 1 beta	Homo sapiens	24-32
15390113-8	2004	Caffeic acid phenethyl ester (CAPE), a specific inhibitor of NF-kappaB activation, not only abrogated IL-1beta-induced NF-kappaB promoter activation, but also blocked IL-1beta-mediated induction of NK-1R gene expression.	caffeic acid phenethyl ester	0-28	interleukin 1 beta	Homo sapiens	102-110
15390113-8	2004	Caffeic acid phenethyl ester (CAPE), a specific inhibitor of NF-kappaB activation, not only abrogated IL-1beta-induced NF-kappaB promoter activation, but also blocked IL-1beta-mediated induction of NK-1R gene expression.	caffeic acid phenethyl ester	0-28	interleukin 1 beta	Homo sapiens	167-175
15390113-8	2004	Caffeic acid phenethyl ester (CAPE), a specific inhibitor of NF-kappaB activation, not only abrogated IL-1beta-induced NF-kappaB promoter activation, but also blocked IL-1beta-mediated induction of NK-1R gene expression.	caffeic acid phenethyl ester	30-34	interleukin 1 beta	Homo sapiens	102-110
15390113-8	2004	Caffeic acid phenethyl ester (CAPE), a specific inhibitor of NF-kappaB activation, not only abrogated IL-1beta-induced NF-kappaB promoter activation, but also blocked IL-1beta-mediated induction of NK-1R gene expression.	caffeic acid phenethyl ester	30-34	interleukin 1 beta	Homo sapiens	167-175
15491790-6	2004	The treatment with gamma-MSH (1 microg), an MC3 receptor agonist, resulted in significant reduction of the IL-1beta-induced plasma corticosterone levels.	Corticosterone	131-145	interleukin 1 beta	Homo sapiens	107-115
15491790-9	2004	When alpha-MSH was given at a lower dose (0.1 microg), it did not modify corticosterone levels but caused an inhibitory effect on the corticosterone release induced by IL-1beta.	Corticosterone	134-148	interleukin 1 beta	Homo sapiens	168-176
15530708-6	2004	Signalling factors involved in labour at term or in infection-induced preterm labour, such as PGE2 or IL-1beta, are also able to induce PDE4B2 expression by way of a cAMP-dependent pathway.	Cyclic AMP	166-170	interleukin 1 beta	Homo sapiens	102-110
15527968-4	2004	The activation of both genes by interleukin 1beta was abrogated by the proteasomal inhibitor, lactacystin which blocks activation of NF-kappaB by preventing IkappaB degradation.	lactacystin	94-105	interleukin 1 beta	Homo sapiens	32-49
15550066-5	2004	Effects of PD98059, SB202190 and SP600125 (inhibitors of ERK, p38 and JNK, respectively) on IL-1beta-induced secretion of IL-6 and IL-8, and on IL-1beta-induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	11-18	interleukin 1 beta	Homo sapiens	92-100
15550066-5	2004	Effects of PD98059, SB202190 and SP600125 (inhibitors of ERK, p38 and JNK, respectively) on IL-1beta-induced secretion of IL-6 and IL-8, and on IL-1beta-induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	20-28	interleukin 1 beta	Homo sapiens	92-100
15550066-5	2004	Effects of PD98059, SB202190 and SP600125 (inhibitors of ERK, p38 and JNK, respectively) on IL-1beta-induced secretion of IL-6 and IL-8, and on IL-1beta-induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied.	pyrazolanthrone	33-41	interleukin 1 beta	Homo sapiens	92-100
15550066-8	2004	Both SB202190 and SP600125 suppressed IL-1beta-induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta-induced secretion of IL-8.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	5-13	interleukin 1 beta	Homo sapiens	38-46
15550066-8	2004	Both SB202190 and SP600125 suppressed IL-1beta-induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta-induced secretion of IL-8.	pyrazolanthrone	18-26	interleukin 1 beta	Homo sapiens	38-46
15550066-8	2004	Both SB202190 and SP600125 suppressed IL-1beta-induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta-induced secretion of IL-8.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	87-94	interleukin 1 beta	Homo sapiens	106-114
15550066-9	2004	Both SB202190 and PD98059 suppressed IL-1beta-induced expression of COX-2 in endometriotic cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	interleukin 1 beta	Homo sapiens	37-45
15458513-5	2004	RESULTS: Increased interleukin 1beta (IL1beta) and IL8 release by in vitro cultured normal PBMC was observed after stimulation with LTA at concentrations &gt; or =5 microg/mL; these levels were lower than for lipopolysaccharide (LPS)-stimulated cells and LTA antagonized LPS-induced cytokine release by normal PBMC.	lipoteichoic acid	132-135	interleukin 1 beta	Homo sapiens	19-36
15502050-3	2004	We investigated the hypothesis that preincisional IV pentoxifylline (PTX) treatment could attenuate the release of proinflammatory (tumor necrosis factor, interleukin (IL)-1beta, IL-6, and IL-8) and antiinflammatory (IL-1 receptor antagonist) cytokines in patients who underwent elective colorectal cancer surgery.	Pentoxifylline	53-67	interleukin 1 beta	Homo sapiens	155-177
15502050-3	2004	We investigated the hypothesis that preincisional IV pentoxifylline (PTX) treatment could attenuate the release of proinflammatory (tumor necrosis factor, interleukin (IL)-1beta, IL-6, and IL-8) and antiinflammatory (IL-1 receptor antagonist) cytokines in patients who underwent elective colorectal cancer surgery.	Pentoxifylline	69-72	interleukin 1 beta	Homo sapiens	155-177
15638042-6	2004	RESULTS: Production of the secretedforms of IL-1beta and IL-6 was inhibited by TauCl with IC50 approximately equal to 250 microM and 300-400 microM respectively, in all investigated groups.	taucl	79-84	interleukin 1 beta	Homo sapiens	44-52
15458513-5	2004	RESULTS: Increased interleukin 1beta (IL1beta) and IL8 release by in vitro cultured normal PBMC was observed after stimulation with LTA at concentrations &gt; or =5 microg/mL; these levels were lower than for lipopolysaccharide (LPS)-stimulated cells and LTA antagonized LPS-induced cytokine release by normal PBMC.	lipoteichoic acid	132-135	interleukin 1 beta	Homo sapiens	38-45
15591777-5	2004	Exposure of cells to CO or a CO donor, the tricarbonyldichlororuthenium(II) dimer, also markedly inhibited IL-1beta-induced iNOS expression.	tricarbonyldichlororuthenium(ii)	43-75	interleukin 1 beta	Homo sapiens	107-115
15298980-0	2004	Independent regulation of prostaglandins and monocyte chemoattractant protein-1 by interleukin-1beta and hCG in human endometrial cells.	Prostaglandins	26-40	interleukin 1 beta	Homo sapiens	83-100
15298980-10	2004	hCG inhibits IL-1beta-induced PG level.	Prostaglandins	30-32	interleukin 1 beta	Homo sapiens	13-21
15465624-3	2004	Peripheral administration of the aminopyridazine MW01-070C, beginning 3 weeks after the start of intracerebroventricular infusion of human Abeta1-42, decreased the number of activated astrocytes and microglia and the levels of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha and S100B in the hippocampus.	aminopyridazine	33-48	interleukin 1 beta	Homo sapiens	253-270
15304498-9	2004	These results indicate that ASBT undergoes ubiquitin-proteasome degradation under basal conditions and that ASBT proteasome disposal is increased by IL-1beta due to JNK-regulated serine/threonine phosphorylation of ASBT protein at both Ser-335 and Thr-339.	Serine	179-185	interleukin 1 beta	Homo sapiens	149-157
15304498-9	2004	These results indicate that ASBT undergoes ubiquitin-proteasome degradation under basal conditions and that ASBT proteasome disposal is increased by IL-1beta due to JNK-regulated serine/threonine phosphorylation of ASBT protein at both Ser-335 and Thr-339.	Threonine	186-195	interleukin 1 beta	Homo sapiens	149-157
15304498-9	2004	These results indicate that ASBT undergoes ubiquitin-proteasome degradation under basal conditions and that ASBT proteasome disposal is increased by IL-1beta due to JNK-regulated serine/threonine phosphorylation of ASBT protein at both Ser-335 and Thr-339.	Serine	236-239	interleukin 1 beta	Homo sapiens	149-157
15304498-9	2004	These results indicate that ASBT undergoes ubiquitin-proteasome degradation under basal conditions and that ASBT proteasome disposal is increased by IL-1beta due to JNK-regulated serine/threonine phosphorylation of ASBT protein at both Ser-335 and Thr-339.	Threonine	248-251	interleukin 1 beta	Homo sapiens	149-157
15308667-7	2004	This activity of IL-1beta does not depend on IL-1beta-dependent STAT1-serine phosphorylation but on NF-kappaB-dependent gene induction.	Serine	70-76	interleukin 1 beta	Homo sapiens	17-25
15380193-0	2004	Novel epicatechin derivatives with antioxidant activity modulate interleukin-1beta release in lipopolysaccharide-stimulated human blood.	Catechin	6-17	interleukin 1 beta	Homo sapiens	65-82
15381182-0	2004	Mannose binding lectin enhances IL-1beta and IL-10 induction by non-lipopolysaccharide (LPS) components of Neisseria meningitidis.	Mannose	0-7	interleukin 1 beta	Homo sapiens	32-40
15380193-5	2004	At concentrations up to 20 microM, epicatechin and its derivatives inhibited the production of IL-1beta in whole blood incubated in the presence of E. coli lipopolysaccharide (LPS), in a concentration-dependent manner.	Catechin	35-46	interleukin 1 beta	Homo sapiens	95-103
15369775-7	2004	Spontaneous caspase activation in human islets and cytotoxicity caused by IL-1beta were significantly reduced in the presence of TAT-Bcl-XL and TAT-BH4.	sapropterin	147-151	interleukin 1 beta	Homo sapiens	74-82
15494044-8	2004	CONCLUSIONS: The increased percentage of IL-12- and IL-1beta-producing monocytes in males compared with females in vivo may be induced by testosterone, as the in vitro percentage of IL-12- and IL-1beta-producing monocytes is increased after incubation with physiological concentrations of testosterone.	Testosterone	138-150	interleukin 1 beta	Homo sapiens	193-201
15488155-11	2004	Thus, Gl A+ and AG-EB+ ENC produce IL-1beta, IL-2, IL-4, IL-6, IFN-gamma, TGF-beta1 and TNF-alpha.	gamma-Linolenic Acid	6-10	interleukin 1 beta	Homo sapiens	35-43
15494044-6	2004	RESULTS: A significant increased percentage of IL-12- and IL-1beta-producing monocytes was found after incubation with physiological concentrations of testosterone.	Testosterone	151-163	interleukin 1 beta	Homo sapiens	58-66
15377563-4	2004	RESULTS: High glucose increased IL-1beta expression by 60% compared with cells incubated in 5 mM glucose (p&lt;0.05).	Glucose	14-21	interleukin 1 beta	Homo sapiens	32-40
15494044-8	2004	CONCLUSIONS: The increased percentage of IL-12- and IL-1beta-producing monocytes in males compared with females in vivo may be induced by testosterone, as the in vitro percentage of IL-12- and IL-1beta-producing monocytes is increased after incubation with physiological concentrations of testosterone.	Testosterone	138-150	interleukin 1 beta	Homo sapiens	52-60
15271788-9	2004	The PPARgamma activator, 15d-PGJ(2), however, inhibited IL-1beta-induced upregulation of LOX-1.	15d-pgj	25-32	interleukin 1 beta	Homo sapiens	56-64
15201199-1	2004	The present study evaluated the secretions of interleukin (IL)-1beta and tumor necrosis factor (TNF) alpha by fetal membranes stimulated with group B streptococci (GBS) and lipopolysaccharide (LPS).	gbs	164-167	interleukin 1 beta	Homo sapiens	46-68
15201199-7	2004	The TNFalpha was secreted by amnion and choriodecidua in the presence of LPS or GBS, and stimulation with GBS induced a greater synthesis of IL-1beta than did stimulation with LPS.	gbs	106-109	interleukin 1 beta	Homo sapiens	141-149
15361371-7	2004	RESULTS: PGE(2) significantly inhibited IL1beta induced MCP-1 expression in SF in a dose dependent manner.	Prostaglandins E	9-12	interleukin 1 beta	Homo sapiens	40-47
15361371-12	2004	Inhibition of endogenous PGE(2) synthesis by NSAIDs further enhanced MCP-1 mRNA expression in IL1beta stimulated SF, an effect prevented by addition of exogenous PGE(2).	Prostaglandins E	25-28	interleukin 1 beta	Homo sapiens	94-101
15361371-12	2004	Inhibition of endogenous PGE(2) synthesis by NSAIDs further enhanced MCP-1 mRNA expression in IL1beta stimulated SF, an effect prevented by addition of exogenous PGE(2).	Prostaglandins E	162-165	interleukin 1 beta	Homo sapiens	94-101
15377563-7	2004	Supplementation of IL-1beta in 20 mM glucose medium further increased nitric oxide and NF-kappaB, and accelerated apoptosis, and addition of IL-1ra significantly decreased glucose induced abnormalities and apoptosis.	Glucose	37-44	interleukin 1 beta	Homo sapiens	19-27
15377563-7	2004	Supplementation of IL-1beta in 20 mM glucose medium further increased nitric oxide and NF-kappaB, and accelerated apoptosis, and addition of IL-1ra significantly decreased glucose induced abnormalities and apoptosis.	Nitric Oxide	70-82	interleukin 1 beta	Homo sapiens	19-27
15377563-8	2004	CONCLUSIONS: IL-1beta accelerates apoptosis of retinal capillary cells via activation of NF-kappaB, and the process is exacerbated in high glucose conditions.	Glucose	139-146	interleukin 1 beta	Homo sapiens	13-21
15380914-6	2004	RESULTS: Allicin markedly inhibited the spontaneous and TNF-alpha -induced secretion of IL-1beta, IL-8, IP-10 and MIG from the two different cell lines in a dose-dependent manner and suppressed the expression of IL-8 and IL-1beta mRNA levels.	allicin	9-16	interleukin 1 beta	Homo sapiens	88-96
15380914-6	2004	RESULTS: Allicin markedly inhibited the spontaneous and TNF-alpha -induced secretion of IL-1beta, IL-8, IP-10 and MIG from the two different cell lines in a dose-dependent manner and suppressed the expression of IL-8 and IL-1beta mRNA levels.	allicin	9-16	interleukin 1 beta	Homo sapiens	221-229
15479233-1	2004	In A549 pulmonary cells, the dexamethasone- and budesonide-dependent repression of interleukin-1beta-induced prostaglandin E2 release was mimicked by the steroid antagonist, RU486.	Dexamethasone	29-42	interleukin 1 beta	Homo sapiens	83-100
15256490-3	2004	Here we extend these results by showing that ceramide, a second messenger in both TNFalpha and IL-1beta receptor signaling pathways, is a key downstream sphingosine-based lipid that leads to IGF-I resistance.	Ceramides	45-53	interleukin 1 beta	Homo sapiens	95-103
15256490-3	2004	Here we extend these results by showing that ceramide, a second messenger in both TNFalpha and IL-1beta receptor signaling pathways, is a key downstream sphingosine-based lipid that leads to IGF-I resistance.	sphingosine-based lipid	153-176	interleukin 1 beta	Homo sapiens	95-103
15479233-1	2004	In A549 pulmonary cells, the dexamethasone- and budesonide-dependent repression of interleukin-1beta-induced prostaglandin E2 release was mimicked by the steroid antagonist, RU486.	Budesonide	48-58	interleukin 1 beta	Homo sapiens	83-100
15479233-1	2004	In A549 pulmonary cells, the dexamethasone- and budesonide-dependent repression of interleukin-1beta-induced prostaglandin E2 release was mimicked by the steroid antagonist, RU486.	Dinoprostone	109-125	interleukin 1 beta	Homo sapiens	83-100
15479233-1	2004	In A549 pulmonary cells, the dexamethasone- and budesonide-dependent repression of interleukin-1beta-induced prostaglandin E2 release was mimicked by the steroid antagonist, RU486.	Steroids	154-161	interleukin 1 beta	Homo sapiens	83-100
15479233-1	2004	In A549 pulmonary cells, the dexamethasone- and budesonide-dependent repression of interleukin-1beta-induced prostaglandin E2 release was mimicked by the steroid antagonist, RU486.	Mifepristone	174-179	interleukin 1 beta	Homo sapiens	83-100
15479233-2	2004	Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (&lt;1 microm) was a poor inhibitor, but was able to efficiently antagonize the effects of dexamethasone and budesonide.	Dexamethasone	20-33	interleukin 1 beta	Homo sapiens	85-102
15479233-2	2004	Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (&lt;1 microm) was a poor inhibitor, but was able to efficiently antagonize the effects of dexamethasone and budesonide.	Budesonide	38-48	interleukin 1 beta	Homo sapiens	85-102
15476200-10	2004	In addition, dexamethasone augmented IL-1beta-induced up-regulation of MKP-1, and this was associated with inhibition of ERK, JNK, and p38 MAPK phosphorylation and IL-6 expression.	Dexamethasone	13-26	interleukin 1 beta	Homo sapiens	37-45
15479233-2	2004	Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (&lt;1 microm) was a poor inhibitor, but was able to efficiently antagonize the effects of dexamethasone and budesonide.	Mifepristone	195-200	interleukin 1 beta	Homo sapiens	85-102
15479233-2	2004	Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (&lt;1 microm) was a poor inhibitor, but was able to efficiently antagonize the effects of dexamethasone and budesonide.	Dexamethasone	292-305	interleukin 1 beta	Homo sapiens	85-102
15476228-15	2004	Methotrexate reduced synovial IL-1alpha, IL-1beta, IL-8, IL-10, IL-15, IFNgamma, and TNFalpha mRNA expression, but the effect was significant only for IL-8.	Methotrexate	0-12	interleukin 1 beta	Homo sapiens	41-49
15479233-2	2004	Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (&lt;1 microm) was a poor inhibitor, but was able to efficiently antagonize the effects of dexamethasone and budesonide.	Budesonide	310-320	interleukin 1 beta	Homo sapiens	85-102
15382119-0	2004	Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.	Bilirubin	88-97	interleukin 1 beta	Homo sapiens	0-17
15479432-4	2004	ASMC were induced to synthesize GM-CSF by stimulation with IL-1beta and TNF-alpha followed by 10% human serum.	asmc	0-4	interleukin 1 beta	Homo sapiens	59-67
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Phenobarbital	61-74	interleukin 1 beta	Homo sapiens	13-21
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Bilirubin	79-88	interleukin 1 beta	Homo sapiens	13-21
15319424-8	2004	The present observations indicate that IL-1beta, but not IFN-gamma, has a preferential inhibitory effect on the first phase of glucose-induced insulin release, mostly via an action on previously docked granules.	Glucose	127-134	interleukin 1 beta	Homo sapiens	39-47
15627643-9	2004	SiO(2) nanoparticles strongly biased naive macrophages towards inflammation (M1 polarisation), by selectively inducing production of inflammatory cytokines IL-1beta and TNF-alpha.	Silicon Dioxide	0-6	interleukin 1 beta	Homo sapiens	156-164
15472206-0	2004	Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta.	Pioglitazone	0-12	interleukin 1 beta	Homo sapiens	123-140
15319424-6	2004	TIRF images of single insulin granule motion during a 15-min stimulation by 22 mm glucose in IL-1beta-treated beta-cells showed a marked reduction in the fusion events from previously docked granules during the first phase insulin release.	Glucose	82-89	interleukin 1 beta	Homo sapiens	93-101
15472172-4	2004	LPS- and IL-1beta-mediated SRIF-mRNA induction was blocked by pretreatment with dexamethasone.	Dexamethasone	80-93	interleukin 1 beta	Homo sapiens	9-17
15472206-0	2004	Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta.	Sodium Salicylate	17-34	interleukin 1 beta	Homo sapiens	123-140
15472206-6	2004	IL-1beta secretion from islets was increased by 4-d culture at 600 mg/dl, and this was blocked by pioglitazone.	Pioglitazone	98-110	interleukin 1 beta	Homo sapiens	0-8
15472206-8	2004	Pioglitazone and sodium salicylate thus protect human islets against the detrimental effects of IL-1beta and high glucose by blocking NFkappaB activation and may therefore be useful in retarding the manifestation and progression of diabetes.	Pioglitazone	0-12	interleukin 1 beta	Homo sapiens	96-104
15472206-8	2004	Pioglitazone and sodium salicylate thus protect human islets against the detrimental effects of IL-1beta and high glucose by blocking NFkappaB activation and may therefore be useful in retarding the manifestation and progression of diabetes.	Sodium Salicylate	17-34	interleukin 1 beta	Homo sapiens	96-104
15472206-1	2004	Decreased functional beta-cell mass in type 1 and type 2 diabetes is due to beta-cell apoptosis and impaired secretory function suggested to be mediated, in part, by immune- and/or high-glucose-induced production of IL-1beta acting through the nuclear factor kappaB (NFkappaB)/Fas pathway.	Glucose	186-193	interleukin 1 beta	Homo sapiens	216-224
15472206-2	2004	The aim of this study was to determine whether two drugs believed to block NFkappaB activation, the thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate, can protect human beta-cells against the toxic effects of IL-1beta and high glucose in vitro.	2,4-thiazolidinedione	100-117	interleukin 1 beta	Homo sapiens	263-271
15472206-2	2004	The aim of this study was to determine whether two drugs believed to block NFkappaB activation, the thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate, can protect human beta-cells against the toxic effects of IL-1beta and high glucose in vitro.	Thiazolidinediones	119-128	interleukin 1 beta	Homo sapiens	263-271
15472206-2	2004	The aim of this study was to determine whether two drugs believed to block NFkappaB activation, the thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate, can protect human beta-cells against the toxic effects of IL-1beta and high glucose in vitro.	Pioglitazone	130-142	interleukin 1 beta	Homo sapiens	263-271
15472206-2	2004	The aim of this study was to determine whether two drugs believed to block NFkappaB activation, the thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate, can protect human beta-cells against the toxic effects of IL-1beta and high glucose in vitro.	Sodium Salicylate	186-203	interleukin 1 beta	Homo sapiens	263-271
15472206-4	2004	IL-1beta and 600 mg/dl glucose increased beta-cell apoptosis and abolished short-term glucose-stimulated insulin secretion.	Glucose	86-93	interleukin 1 beta	Homo sapiens	0-8
15324348-4	2004	OBJECTIVES: The objective of this study was to investigate glutathione peroxidase, lactoferrin and myeloperoxidase, which play an essential role in free radical production and defenses, and the proinflammatory cytokine interleukin-1beta (IL-1beta), which is important in the regulation of immunological and inflammatory reactions in human periodontal diseases.	Free Radicals	148-160	interleukin 1 beta	Homo sapiens	219-236
16163465-1	2004	We compared the effects of fosfomycin, an antibiotic reported to possess immunomodulatory activities, and prednisolone on the production of interleukin-1 receptor antagonist (IL-1ra) and IL-1beta by bronchoalveolar lavage fluid (BALF) macrophages obtained from sarcoidosis patients.	Fosfomycin	27-37	interleukin 1 beta	Homo sapiens	187-195
16163465-1	2004	We compared the effects of fosfomycin, an antibiotic reported to possess immunomodulatory activities, and prednisolone on the production of interleukin-1 receptor antagonist (IL-1ra) and IL-1beta by bronchoalveolar lavage fluid (BALF) macrophages obtained from sarcoidosis patients.	Prednisolone	106-118	interleukin 1 beta	Homo sapiens	187-195
16163465-2	2004	The molar IL-1ra/IL-1beta ratio in the culture supernatants of BALF macrophages obtained from sarcoidosis patients, which was lower in sarcoidosis patients than in healthy nonsmokers, was significantly increased in the presence of fosfomycin, but decreased by prednisolone.	Fosfomycin	231-241	interleukin 1 beta	Homo sapiens	17-25
16163465-2	2004	The molar IL-1ra/IL-1beta ratio in the culture supernatants of BALF macrophages obtained from sarcoidosis patients, which was lower in sarcoidosis patients than in healthy nonsmokers, was significantly increased in the presence of fosfomycin, but decreased by prednisolone.	Prednisolone	260-272	interleukin 1 beta	Homo sapiens	17-25
16163465-3	2004	Further, the molar IL-1ra/IL-1beta ratios in the culture supernatants of peripheral blood mononuclear cells isolated from four of five patients after fosfomycin administration for 14 days were higher than the ratios measured before fosfomycin administration.	Fosfomycin	150-160	interleukin 1 beta	Homo sapiens	26-34
15205451-0	2004	Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis.	Hydrogen Peroxide	40-44	interleukin 1 beta	Homo sapiens	0-17
15205451-7	2004	IL-1beta-induced reduction in caffeine-induced peak Ca(2+) increase and contraction was reversed by catalase, suggesting a role of H(2)O(2).	Caffeine	30-38	interleukin 1 beta	Homo sapiens	0-8
15324348-4	2004	OBJECTIVES: The objective of this study was to investigate glutathione peroxidase, lactoferrin and myeloperoxidase, which play an essential role in free radical production and defenses, and the proinflammatory cytokine interleukin-1beta (IL-1beta), which is important in the regulation of immunological and inflammatory reactions in human periodontal diseases.	Free Radicals	148-160	interleukin 1 beta	Homo sapiens	238-246
15205451-7	2004	IL-1beta-induced reduction in caffeine-induced peak Ca(2+) increase and contraction was reversed by catalase, suggesting a role of H(2)O(2).	Water	131-136	interleukin 1 beta	Homo sapiens	0-8
15324348-10	2004	CONCLUSION: The imbalance between the levels of myeloperoxidase/IL-1beta and glutathione peroxidase/lactoferrin could result in tissue damage of reactive oxygen species (ROS) in periodontitis which is initiated and perpetuated by the chronic insults of periodontopathogens.	Reactive Oxygen Species	145-168	interleukin 1 beta	Homo sapiens	64-72
15205451-9	2004	IL-1beta significantly increased the phosphorylation of extracellular signal-regulated kinase 1 (ERK1)/ERK2 MAPKs and cPLA(2) and IL-1beta-induced cPLA(2) phosphorylation was blocked by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	186-193	interleukin 1 beta	Homo sapiens	0-8
15205451-9	2004	IL-1beta significantly increased the phosphorylation of extracellular signal-regulated kinase 1 (ERK1)/ERK2 MAPKs and cPLA(2) and IL-1beta-induced cPLA(2) phosphorylation was blocked by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	186-193	interleukin 1 beta	Homo sapiens	130-138
15324348-10	2004	CONCLUSION: The imbalance between the levels of myeloperoxidase/IL-1beta and glutathione peroxidase/lactoferrin could result in tissue damage of reactive oxygen species (ROS) in periodontitis which is initiated and perpetuated by the chronic insults of periodontopathogens.	Reactive Oxygen Species	170-173	interleukin 1 beta	Homo sapiens	64-72
15205451-11	2004	IL-1beta reproduces these changes, possibly by production of H(2)O(2) via sequential activation of MAPKs (ERK1/ERK2) and cPLA(2).	Hydrogen Peroxide	61-69	interleukin 1 beta	Homo sapiens	0-8
15450530-8	2004	IL-1beta highly stimulated *NO, IL-8, IL-6, MIP-1beta and PGE(2) synthesis but decreased AGG and TGF-beta1 production.	Prostaglandins E	58-61	interleukin 1 beta	Homo sapiens	0-8
15571210-6	2004	The adenosine receptor agonist 5"N-ethylcarboxamido-adenosine (NECA) used to modify cytokine release in cultures of whole blood taken from the patients, depressed the release of tumour necrosis factor-alpha (TNFalpha), but failed to depress the release of interleukin-1b (IL-1b) or interleukin-6 (IL-6), a difference from earlier studies of healthy control subjects and, thus, a difference which may contribute to the disease activity.	Adenosine-5'-(N-ethylcarboxamide)	31-61	interleukin 1 beta	Homo sapiens	256-270
15571210-6	2004	The adenosine receptor agonist 5"N-ethylcarboxamido-adenosine (NECA) used to modify cytokine release in cultures of whole blood taken from the patients, depressed the release of tumour necrosis factor-alpha (TNFalpha), but failed to depress the release of interleukin-1b (IL-1b) or interleukin-6 (IL-6), a difference from earlier studies of healthy control subjects and, thus, a difference which may contribute to the disease activity.	Adenosine-5'-(N-ethylcarboxamide)	31-61	interleukin 1 beta	Homo sapiens	272-277
15571210-6	2004	The adenosine receptor agonist 5"N-ethylcarboxamido-adenosine (NECA) used to modify cytokine release in cultures of whole blood taken from the patients, depressed the release of tumour necrosis factor-alpha (TNFalpha), but failed to depress the release of interleukin-1b (IL-1b) or interleukin-6 (IL-6), a difference from earlier studies of healthy control subjects and, thus, a difference which may contribute to the disease activity.	Adenosine-5'-(N-ethylcarboxamide)	63-67	interleukin 1 beta	Homo sapiens	256-270
15571210-6	2004	The adenosine receptor agonist 5"N-ethylcarboxamido-adenosine (NECA) used to modify cytokine release in cultures of whole blood taken from the patients, depressed the release of tumour necrosis factor-alpha (TNFalpha), but failed to depress the release of interleukin-1b (IL-1b) or interleukin-6 (IL-6), a difference from earlier studies of healthy control subjects and, thus, a difference which may contribute to the disease activity.	Adenosine-5'-(N-ethylcarboxamide)	63-67	interleukin 1 beta	Homo sapiens	272-277
15229295-4	2004	We report the novel finding that inhibition of PARG by gallotannin triggered nuclear accumulation of PAR and concomitant PAR-dependent expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), but not of interleukin-1beta and tumor necrosis factor-alpha, in cultured RAW 264.7 macrophages.	Hydrolyzable Tannins	55-66	interleukin 1 beta	Homo sapiens	219-268
15532546-7	2004	In contrast, only lovastatin significantly increased levels of IL-1beta and of TNFalpha in a dose-dependent manner.	Lovastatin	18-28	interleukin 1 beta	Homo sapiens	63-71
15450530-11	2004	At 1-10ng/ml, OSM significantly decreased IL-1beta-stimulated IL-8, MIP-1beta, PGE(2) and *NO production but amplified IL-1beta stimulating effect on IL-6 production.	Prostaglandins E	79-82	interleukin 1 beta	Homo sapiens	42-50
15238642-9	2004	Production/release of IL-1beta was inhibited by MTX, whereas its effects on target cells were not.	Methotrexate	48-51	interleukin 1 beta	Homo sapiens	22-30
15219635-6	2004	In analyses adjusting for age, body mass index (BMI), fasting cholesterol, alcohol use, race and 17beta-estradiol (E(2)), higher Ho scores were associated with greater LPS-stimulated expression of IL-1alpha (beta = 0.033, p = 0.02), IL-8 (beta = 0.046, p = 0.01) and IL-1beta (beta = 0.024, p = 0.06).	Estradiol	97-113	interleukin 1 beta	Homo sapiens	267-275
15251176-9	2004	When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated.	Samarium	33-35	interleukin 1 beta	Homo sapiens	137-145
15251176-9	2004	When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated.	SB 203580	83-91	interleukin 1 beta	Homo sapiens	137-145
15383690-0	2004	Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells.	hyaluronate	0-11	interleukin 1 beta	Homo sapiens	25-42
15251176-2	2004	Previous work has revealed that SM induces the production of inflammatory cytokines, including IL-8, IL-6, TNF-alpha, and IL-1beta, in keratinocytes.	Samarium	32-34	interleukin 1 beta	Homo sapiens	122-130
15117678-6	2004	Expression of IL-1beta, IL-6, IL-8, and COX-2 mRNA was reduced by 30 microM PP1, an Src family tyrosine kinase inhibitor, and by 25 microM SB-203580, a p38 MAPK inhibitor.	SB 203580	139-148	interleukin 1 beta	Homo sapiens	14-22
15383152-7	2004	However, IL-6, IL-8, and IL-13 production induced by IL-1 beta were significantly enhanced by addition of epinephrine.	Epinephrine	106-117	interleukin 1 beta	Homo sapiens	53-62
15363968-6	2004	We conclude that brief ischemia of remote preconditioning such as heart or liver protects gastric mucosa against severe ischemia-reperfusion-induced gastric lesions as effectively as local preconditioning of the stomach itself via the mechanism involving prostaglandin derived from cyclooxygenase-1 and cyclooxygenase-2 and the activation of sensory nerves releasing calcitonin gene-related peptide (CGRP) combined with the suppression of interleukin-1beta and TNF-alpha expression and release.	Prostaglandins	255-268	interleukin 1 beta	Homo sapiens	439-456
15373762-11	2004	Adding IL-1beta increased beta-hCG production in a dose-dependent manner, and the addition of TPCK neutralized the effect of IL-1beta.	beta-hcg	26-34	interleukin 1 beta	Homo sapiens	7-15
15191916-6	2004	Accordingly, Bay-11 7082, an inhibitor of NF-kappaB activation, inhibited IL-1beta-induced IL-13 and MCP-1 expression.	3-(4-methylphenylsulfonyl)-2-propenenitrile	13-24	interleukin 1 beta	Homo sapiens	74-82
15191916-8	2004	Dexamethasone, a glucocorticoid, inhibited IL-1beta-induced nuclear translocation of NF-kappaB and also the secretion of IL-13 from mast cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	43-51
15457451-7	2004	Incubation with IL-1beta markedly increased mPGES-1 mRNA and protein in a dose-dependent and time-dependent manner, in parallel with an increase in PGE(2) levels.	Prostaglandins E	45-48	interleukin 1 beta	Homo sapiens	16-24
15457451-8	2004	Both PD98059, an ERK pathway inhibitor, and SB203580, a p38alpha/beta MAPK inhibitor, abolished the increases in mPGES-1 mRNA and protein in response to IL-1beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	5-12	interleukin 1 beta	Homo sapiens	153-161
15457451-8	2004	Both PD98059, an ERK pathway inhibitor, and SB203580, a p38alpha/beta MAPK inhibitor, abolished the increases in mPGES-1 mRNA and protein in response to IL-1beta.	SB 203580	44-52	interleukin 1 beta	Homo sapiens	153-161
15457451-9	2004	The specific p38alpha MAPK inhibitor SC906 suppressed IL-1beta-induced COX-2 expression but not IL-1beta-induced mPGES-1 expression, suggesting preferential involvement of p38beta MAPK in IL-1beta-induced mPGES-1 expression.	sc906	37-42	interleukin 1 beta	Homo sapiens	54-62
15342370-2	2004	We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with the "classical" type-1-polarizing cytokine cocktail [tumor necrosis factor alpha (TNFalpha)/IL-1beta/IFNgamma], allowing for serum-free generation of fully mature type-1-polarized DCs (DC1).	Poly C	40-58	interleukin 1 beta	Homo sapiens	174-182
15312171-5	2004	15d-PGJ2 was a potent inhibitor of proinflammatory cytokine (IL-1beta, TNF-alpha, IL-12 p40) and CC chemokine (MIP-1beta, MCP-1) production in primary microglia, but had no effect upon the expression of select CXC chemokines (MIP-2, KC).	15-deoxy-delta(12,14)-prostaglandin J2	0-8	interleukin 1 beta	Homo sapiens	61-69
15480896-11	2004	IL1beta-mediated NFkappaB was completely inhibited in the presence of lactacystin, a potent inhibitor of NFkappaB.	lactacystin	70-81	interleukin 1 beta	Homo sapiens	0-7
15358691-8	2004	cAMP increased constitutive and TNF-alpha-stimulated IL-1beta release but reduced that of sIL-1RII.	Cyclic AMP	0-4	interleukin 1 beta	Homo sapiens	53-61
15358691-11	2004	Tumour necrosis factor-alpha, cyclic adenosine monophosphate and cyclic guanosine monophosphate may potentiate mucosal inflammation by increasing interleukin-1beta levels relative to those of its inhibitors in the airway mucosa.	Cyclic AMP	30-60	interleukin 1 beta	Homo sapiens	146-163
15358691-11	2004	Tumour necrosis factor-alpha, cyclic adenosine monophosphate and cyclic guanosine monophosphate may potentiate mucosal inflammation by increasing interleukin-1beta levels relative to those of its inhibitors in the airway mucosa.	Cyclic GMP	65-95	interleukin 1 beta	Homo sapiens	146-163
15322215-3	2004	15d-PGJ(2) potently inhibited the expression of microglial cytokines (IL-1, TNF-alpha, and IL-6).	15d-pgj	0-7	interleukin 1 beta	Homo sapiens	70-74
15320915-0	2004	Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1beta stimulated rheumatoid synovial fibroblasts.	Leflunomide	22-33	interleukin 1 beta	Homo sapiens	91-99
15320915-3	2004	We investigated the effects of A77 1726, leflunomide"s active metabolite, on mitogen-activated protein kinase (MAPK) activation in IL-1beta-stimulated rheumatoid synovial fibroblasts.	Leflunomide	41-52	interleukin 1 beta	Homo sapiens	131-139
15295712-0	2004	Modification of prostanoid secretion in endothelial cells by amphotericin B acting synergistically with interleukin-1beta: possible explanation of proinflammatory effects.	Prostaglandins	16-26	interleukin 1 beta	Homo sapiens	104-121
15295712-3	2004	Measurement of the resulting prostanoids indicated that amphotericin B and IL-1 beta acted synergistically to increase the ability of endothelial cells to synthesize prostanoids from endogenous and exogenous substrate and to increase expression of cyclooxygenase-2.	Prostaglandins	29-40	interleukin 1 beta	Homo sapiens	75-84
15295712-3	2004	Measurement of the resulting prostanoids indicated that amphotericin B and IL-1 beta acted synergistically to increase the ability of endothelial cells to synthesize prostanoids from endogenous and exogenous substrate and to increase expression of cyclooxygenase-2.	Prostaglandins	166-177	interleukin 1 beta	Homo sapiens	75-84
15295712-6	2004	The synergistic effect with IL-1 beta was observed with free-form amphotericin B and, to a lesser extent, with lipid-complexed amphotericin B (Abelcet).	Amphotericin B	66-80	interleukin 1 beta	Homo sapiens	28-37
15295712-6	2004	The synergistic effect with IL-1 beta was observed with free-form amphotericin B and, to a lesser extent, with lipid-complexed amphotericin B (Abelcet).	Amphotericin B	127-141	interleukin 1 beta	Homo sapiens	28-37
15515334-12	2004	RESULTS: Clinical periodontal measures (PD, AL, BOP) and measures of glycemic control (HbA1c, random glucose) were significantly correlated with GCF IL-1beta.	Glucose	101-108	interleukin 1 beta	Homo sapiens	149-157
15515334-14	2004	In a multivariate model adjusting for age, gender, PD, AL, BOP, and PI, HbA1c and random glucose were independent predictors of high GCF IL-1beta.	bop	59-62	interleukin 1 beta	Homo sapiens	137-145
15515334-14	2004	In a multivariate model adjusting for age, gender, PD, AL, BOP, and PI, HbA1c and random glucose were independent predictors of high GCF IL-1beta.	Glucose	89-96	interleukin 1 beta	Homo sapiens	137-145
15320881-3	2004	16-phe-LXA4, LPS and LTB4, but not LXA4, induced gene expression of IL-1beta in MO.	Phenylalanine	2-6	interleukin 1 beta	Homo sapiens	68-76
15362934-0	2004	Influence of eicosapentaenoic acid, an omega-3 fatty acid, on ultraviolet-B generation of prostaglandin-E2 and proinflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 in human skin in vivo.	Eicosapentaenoic Acid	13-34	interleukin 1 beta	Homo sapiens	137-155
15526907-6	2004	Importantly, PPARgamma agonists troglitazone, rosiglitazone, and 15-deoxy-delta(12, 14)-prosglandin J2 significantly decreased the up expression of TNF-alpha and IL-6 in HMCL supernatants stimulated by IL-1beta.	Troglitazone	32-44	interleukin 1 beta	Homo sapiens	202-210
15526907-6	2004	Importantly, PPARgamma agonists troglitazone, rosiglitazone, and 15-deoxy-delta(12, 14)-prosglandin J2 significantly decreased the up expression of TNF-alpha and IL-6 in HMCL supernatants stimulated by IL-1beta.	Rosiglitazone	46-59	interleukin 1 beta	Homo sapiens	202-210
15320881-8	2004	Prior exposure of MO to 16-phe-LXA4, but not LXA4, reduced LTB4 induced synthesis of IL-1beta with 66%, IL-6 with 20% and IL-1Ra with 29%.	16-phe-lxa4	24-35	interleukin 1 beta	Homo sapiens	85-93
15526907-7	2004	Furthermore, troglitazone downregulated TNF-alpha and IL-6 mRNA expression from IL-1beta challenge HMCLs.	Troglitazone	13-25	interleukin 1 beta	Homo sapiens	80-88
15526907-7	2004	Furthermore, troglitazone downregulated TNF-alpha and IL-6 mRNA expression from IL-1beta challenge HMCLs.	hmcls	99-104	interleukin 1 beta	Homo sapiens	80-88
15208668-0	2004	Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells.	Reactive Oxygen Species	68-71	interleukin 1 beta	Homo sapiens	0-17
15294346-0	2004	Production of macrophage IL-1beta was inhibited both at the levels of transcription and maturation by caspase-1 following inhalation exposure to isobutyl nitrite.	isobutyl nitrite	145-161	interleukin 1 beta	Homo sapiens	25-33
15294346-4	2004	IL-1beta mRNA transcription was reduced by 35% following nitrite inhalant exposure, consistent with inhibition of activation-induced phosphorylation of macrophage mitogen-activated protein kinase p38.	Nitrites	57-64	interleukin 1 beta	Homo sapiens	0-8
15294346-7	2004	Nitrite inhalant exposure blocked activation-induced increases in caspase-1 activity, consistent with a 50% reduction in 17 kDa IL-1beta shown in Western blots.	Nitrites	0-7	interleukin 1 beta	Homo sapiens	128-136
15294346-8	2004	Thus, exposure to nitrite inhalants reduced macrophage production of IL-1beta by reducing transcription, as well as post-translational processing mediated by caspase-1.	Nitrites	18-25	interleukin 1 beta	Homo sapiens	69-77
15208668-7	2004	IL-1beta also induced the production of reactive oxygen species (ROS).	Reactive Oxygen Species	40-63	interleukin 1 beta	Homo sapiens	0-8
15208668-7	2004	IL-1beta also induced the production of reactive oxygen species (ROS).	Reactive Oxygen Species	65-68	interleukin 1 beta	Homo sapiens	0-8
15208668-8	2004	N-acetyl cysteine (NAC) prevented the IL-1beta-induced ROS production and IL-8 expression.	Acetylcysteine	0-17	interleukin 1 beta	Homo sapiens	38-46
15287722-2	2004	Potent p38 inhibitors, such as the slow tight-binding inhibitor BIRB 796, have recently been reported to block the production of TNFalpha and IL-1beta.	doramapimod	64-72	interleukin 1 beta	Homo sapiens	142-150
15208668-8	2004	N-acetyl cysteine (NAC) prevented the IL-1beta-induced ROS production and IL-8 expression.	Acetylcysteine	19-22	interleukin 1 beta	Homo sapiens	38-46
15208668-8	2004	N-acetyl cysteine (NAC) prevented the IL-1beta-induced ROS production and IL-8 expression.	Reactive Oxygen Species	55-58	interleukin 1 beta	Homo sapiens	38-46
15208668-14	2004	The above results suggest that MAPK-AP-1 and ROS-NF-kappaB signaling pathways are involved in the IL-1beta-induced IL-8 expression and that these paracrine signaling pathways induce endothelial cell proliferation.	Reactive Oxygen Species	45-48	interleukin 1 beta	Homo sapiens	98-106
15317861-9	2004	Taken together, these results suggest that IL-1 and fractalkine are endogenous regulators of morphine analgesia and are involved in the increases in pain sensitivity that occur after chronic opiates.	Morphine	93-101	interleukin 1 beta	Homo sapiens	43-47
15673165-0	2004	Protective effects of benzisothiazolylamidines on IL-1 beta induced alterations in human articular chondrocyte metabolism.	benzisothiazolylamidines	22-46	interleukin 1 beta	Homo sapiens	50-59
15302608-4	2004	Stepwise regression analysis showed that there were significantly positive correlations between IL-1beta and IL-6, IL-1beta and nitric oxide, IL-4 and tumor-necrosis factor (TNF)-alpha, IL-4 and leptin, IL-8 and IL-2, and interferon (IFN)-gamma and IL-6, as well as significantly inversed correlations between IL-6 and IL-2, IL-8 and interferon-gamma, and leptin and TNF-alpha in siblings, not in the children with diabetes.	Nitric Oxide	128-140	interleukin 1 beta	Homo sapiens	96-104
15302608-4	2004	Stepwise regression analysis showed that there were significantly positive correlations between IL-1beta and IL-6, IL-1beta and nitric oxide, IL-4 and tumor-necrosis factor (TNF)-alpha, IL-4 and leptin, IL-8 and IL-2, and interferon (IFN)-gamma and IL-6, as well as significantly inversed correlations between IL-6 and IL-2, IL-8 and interferon-gamma, and leptin and TNF-alpha in siblings, not in the children with diabetes.	Nitric Oxide	128-140	interleukin 1 beta	Homo sapiens	115-123
15332399-7	2004	In the CF patients, sputum iron was positively and strongly related to IL-1beta, TNF-alpha, ferritin and microalbumin levels, but negatively related to forced expiratory volume in one second % predicted.	Iron	27-31	interleukin 1 beta	Homo sapiens	71-79
15275879-11	2004	Pretreatment of fibroblasts with the Jun N-terminal kinase inhibitor dimethylaminopurine abolished TNF-alpha- and IL-1beta-stimulated ICAM-1 expression.	N(6),N(6)-dimethyladenine	69-88	interleukin 1 beta	Homo sapiens	114-122
15271731-2	2004	We investigated the hypothesis that epidural clonidine premedication and postoperative patient-controlled epidural analgesia (PCEA) including clonidine would decrease the release of proinflammatory (interleukin (IL)-6, IL-1beta, IL-8, and tumor necrosis factor (TNF)-alpha) and antiinflammatory (IL-1 receptor antagonist (RA)) cytokines in patients who underwent elective colorectal surgery and that they would provide better postoperative analgesia.	Clonidine	45-54	interleukin 1 beta	Homo sapiens	219-227
15271731-2	2004	We investigated the hypothesis that epidural clonidine premedication and postoperative patient-controlled epidural analgesia (PCEA) including clonidine would decrease the release of proinflammatory (interleukin (IL)-6, IL-1beta, IL-8, and tumor necrosis factor (TNF)-alpha) and antiinflammatory (IL-1 receptor antagonist (RA)) cytokines in patients who underwent elective colorectal surgery and that they would provide better postoperative analgesia.	Clonidine	142-151	interleukin 1 beta	Homo sapiens	219-227
15598423-4	2004	Our results show that thalidomide and IMiDs inhibited the expression of COX-2 but not the COX-1 protein in LPS-TNF-alpha and IL-1beta stimulated PBMC and shortened the half-life of COX-2 mRNA in a dose-dependent manner.	Thalidomide	22-33	interleukin 1 beta	Homo sapiens	125-133
15180965-8	2004	Although PGE2 also induces IL-1beta and IL-6 expression in non-stimulated DCs, the stimulatory effect of PGE2 on IL-23 production is not mediated through IL-1beta or IL-6.	Dinoprostone	9-13	interleukin 1 beta	Homo sapiens	27-35
15673165-3	2004	Human chondrocytes were treated with IL-1beta in the presence of a series of N-benzo[d]isothiazol-3-yl-amidines at a concentration of 100 microg/mL.	n-benzo[d]isothiazol-3-yl-amidines	77-111	interleukin 1 beta	Homo sapiens	37-45
15673165-5	2004	Nitrite production induced by inflammatory IL-1beta on cultured chondrocytes was inhibited by the N-benzo[d]isothiazol-3-yl-amidines tested, in particular by N-benzo[d]isothiazol-3-yl-benzamidine, which was the most active.	Nitrites	0-7	interleukin 1 beta	Homo sapiens	43-51
15673165-5	2004	Nitrite production induced by inflammatory IL-1beta on cultured chondrocytes was inhibited by the N-benzo[d]isothiazol-3-yl-amidines tested, in particular by N-benzo[d]isothiazol-3-yl-benzamidine, which was the most active.	n-benzo[d]isothiazol-3-yl-amidines	98-132	interleukin 1 beta	Homo sapiens	43-51
15673165-5	2004	Nitrite production induced by inflammatory IL-1beta on cultured chondrocytes was inhibited by the N-benzo[d]isothiazol-3-yl-amidines tested, in particular by N-benzo[d]isothiazol-3-yl-benzamidine, which was the most active.	Benzenecarboximidamide, N-1,2-benzisothiazol-3-yl-	158-195	interleukin 1 beta	Homo sapiens	43-51
15673165-6	2004	Concerning the effects on GAGs, all the tested benzisothiazolylamidines, and in particular N-benzo[d]isothiazol-3-yl-acetamidine, prevented the depletion of proteoglycan induced by IL-1beta.	benzisothiazolylamidines	47-71	interleukin 1 beta	Homo sapiens	181-189
15673165-6	2004	Concerning the effects on GAGs, all the tested benzisothiazolylamidines, and in particular N-benzo[d]isothiazol-3-yl-acetamidine, prevented the depletion of proteoglycan induced by IL-1beta.	Ethanimidamide, N-1,2-benzisothiazol-3-yl-	91-128	interleukin 1 beta	Homo sapiens	181-189
15265936-4	2004	We found that celecoxib suppressed NF-kappa B activation induced by various carcinogens, including TNF, phorbol ester, okadaic acid, LPS, and IL-1 beta.	Celecoxib	14-23	interleukin 1 beta	Homo sapiens	142-151
15304040-5	2004	ATRA treatment was associated with a significant decrease in TF gene expression in bone marrow cells during the first 30 days of treatment, whereas IL-1 beta gene expression, which decreased in the cells of six patients treated with either chemotherapy or ATRA, actually increased in the remaining six patients treated with either chemotherapy or ATRA.	Tretinoin	256-260	interleukin 1 beta	Homo sapiens	148-157
15304040-5	2004	ATRA treatment was associated with a significant decrease in TF gene expression in bone marrow cells during the first 30 days of treatment, whereas IL-1 beta gene expression, which decreased in the cells of six patients treated with either chemotherapy or ATRA, actually increased in the remaining six patients treated with either chemotherapy or ATRA.	Tretinoin	256-260	interleukin 1 beta	Homo sapiens	148-157
15266025-3	2004	We found that IL-1beta increased cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin (PG) E(2) production and that the COX-2 inhibitor celecoxib suppressed IL-1beta-induced MUC5AC production.	Dinoprostone	78-101	interleukin 1 beta	Homo sapiens	14-22
15266025-3	2004	We found that IL-1beta increased cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin (PG) E(2) production and that the COX-2 inhibitor celecoxib suppressed IL-1beta-induced MUC5AC production.	Celecoxib	142-151	interleukin 1 beta	Homo sapiens	14-22
15266025-9	2004	We conclude that the induction of MUC5AC by IL-1beta, TNF-alpha, PAF, and LPS involves COX-2- generated PGE(2), activation of EP2 and/or EP4 receptor(s), and cAMP-PKA-mediated signaling.	Prostaglandins E	104-107	interleukin 1 beta	Homo sapiens	44-52
15266025-3	2004	We found that IL-1beta increased cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin (PG) E(2) production and that the COX-2 inhibitor celecoxib suppressed IL-1beta-induced MUC5AC production.	Celecoxib	142-151	interleukin 1 beta	Homo sapiens	163-171
15266025-9	2004	We conclude that the induction of MUC5AC by IL-1beta, TNF-alpha, PAF, and LPS involves COX-2- generated PGE(2), activation of EP2 and/or EP4 receptor(s), and cAMP-PKA-mediated signaling.	Cyclic AMP	158-162	interleukin 1 beta	Homo sapiens	44-52
15258595-3	2004	Dendrimer glucosamine inhibited Toll-like receptor 4-mediated lipopolysaccharide induced synthesis of pro-inflammatory chemokines (MIP-1 alpha, MIP-1 beta, IL-8) and cytokines (TNF-alpha, IL-1 beta, IL-6) from human dendritic cells and macrophages but allowed upregulation of the costimulatory molecules CD25, CD80, CD83 and CD86.	Glucosamine	10-21	interleukin 1 beta	Homo sapiens	188-197
15173165-9	2004	IL-1 beta activated phosphatidylinositol (PI) 3-kinase, the enzyme activity of which was greatly stimulated after a 5-min exposure to IL-1 beta.	Phosphatidylinositols	20-40	interleukin 1 beta	Homo sapiens	0-9
15296730-1	2004	Caspase-1, a mediator of the posttranslational processing of IL-1beta and IL-18, requires an aspartic acid in the P1 position of its substrates.	Aspartic Acid	93-106	interleukin 1 beta	Homo sapiens	61-69
15173165-9	2004	IL-1 beta activated phosphatidylinositol (PI) 3-kinase, the enzyme activity of which was greatly stimulated after a 5-min exposure to IL-1 beta.	Phosphatidylinositols	20-40	interleukin 1 beta	Homo sapiens	134-143
15173165-6	2004	Biological activities of IL-1 beta were further determined; IL-1 beta altered the shape of CECs from polygonal to fibroblastic morphologies in a time- and dose-dependent manner, whereas neutralizing IL-1 beta antibody, neutralizing antibody to FGF-2, and LY294002 blocked the action of IL-1 beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	interleukin 1 beta	Homo sapiens	25-34
15173165-10	2004	This early and rapid activation of PI 3-kinase greatly enhanced FGF-2 production in CECs; pretreatment with LY294002 hampered the induction activity of IL-1 beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	interleukin 1 beta	Homo sapiens	152-161
15184060-4	2004	NAA also decreased the levels of COX-2 protein and activated NF-kappaB in IL-1beta-stimulated STTG cells but had little effect on unstimulated cells.	N-acetylaspartate	0-3	interleukin 1 beta	Homo sapiens	74-82
15039285-6	2004	Binding of (125)I-IL-1beta to Sepharose-immobilized fibrinogen also demonstrated a single binding site with an apparent K(d) of 3.5 nM.	Sepharose	30-39	interleukin 1 beta	Homo sapiens	18-26
15039285-9	2004	Compared with free form, fibrinogen-bound IL-1beta stimulated increased activation of endothelial cell nuclear factor kappaB (NF-kappaB), monocyte chemoattractant protein-1 (MCP-1) secretion, and nitric oxide (NO) synthesis.	Nitric Oxide	196-208	interleukin 1 beta	Homo sapiens	42-50
15240151-7	2004	Importantly, IL-1beta-induced HBD-2 mRNA expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors, including pyrrolidine dithiocarbamate and MG132.	pyrrolidine dithiocarbamic acid	140-167	interleukin 1 beta	Homo sapiens	13-21
15240151-7	2004	Importantly, IL-1beta-induced HBD-2 mRNA expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors, including pyrrolidine dithiocarbamate and MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	172-177	interleukin 1 beta	Homo sapiens	13-21
15240151-8	2004	Specifically, IL-1beta-induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K-dependent nuclear translocation of NF-kappaB in response to IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	interleukin 1 beta	Homo sapiens	14-22
15240151-8	2004	Specifically, IL-1beta-induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K-dependent nuclear translocation of NF-kappaB in response to IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	interleukin 1 beta	Homo sapiens	224-232
15240151-8	2004	Specifically, IL-1beta-induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K-dependent nuclear translocation of NF-kappaB in response to IL-1beta.	bisindolylmaleimide I	113-122	interleukin 1 beta	Homo sapiens	14-22
15090544-3	2004	We used the PPAR agonist rosiglitazone (Rtz) to investigate PPAR-gamma isotype on IL-1beta-target genes.	Rosiglitazone	25-38	interleukin 1 beta	Homo sapiens	82-90
15090544-3	2004	We used the PPAR agonist rosiglitazone (Rtz) to investigate PPAR-gamma isotype on IL-1beta-target genes.	Rosiglitazone	40-43	interleukin 1 beta	Homo sapiens	82-90
14764429-10	2004	Further, fluticasone attenuated IL-1beta and TNF-alpha stimulated hyaluronan synthase-2 messenger RNA (mRNA), and the addition of salmeterol cooperatively enhanced this inhibition.	Fluticasone	9-20	interleukin 1 beta	Homo sapiens	32-40
14764429-8	2004	Fluticasone inhibited IL-1beta and TNF-alpha induced HA synthesis (44.5%) whereas salmeterol had no effect.	Fluticasone	0-11	interleukin 1 beta	Homo sapiens	22-30
15016613-5	2004	Application of 5 x 10(6) PMNs to the serosal surface of ischemia-injured mucosa significantly enhanced recovery of TER (P &lt; 0.05), an effect that was inhibited by the selective COX-2 inhibitor NS-398 (5 microM) and by an IL-1beta receptor antagonist (0.1 mg/ml).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	196-202	interleukin 1 beta	Homo sapiens	224-232
14967525-0	2004	Preparation of novel mesoporous carbons for the adsorption of an inflammatory cytokine (IL-1 beta).	Carbon	32-39	interleukin 1 beta	Homo sapiens	88-97
15194586-0	2004	Simvastatin reduces MMP-3 level in interleukin 1beta stimulated human chondrocyte culture.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	35-52
15194586-8	2004	Incubation with simvastatin was associated with a dose dependent reduction in MMP-3 increase, both in the presence (-15%, -17%, and -26% with 5, 10, and 50 micromol/l, respectively) and in the absence (-32% with 50 micromol/l) of IL1beta.	Simvastatin	16-27	interleukin 1 beta	Homo sapiens	230-237
15194586-10	2004	CONCLUSIONS: Our data show that simvastatin, by blocking HMGCoA-reductase and interfering in the prenylation processes, is able to inhibit MMP-3 production from cultured human chondrocytes that have been either unstimulated or stimulated with IL1beta, thus suggesting a possible additional mechanism for statins in counteracting chronic joint disease related cartilage damage.	Simvastatin	32-43	interleukin 1 beta	Homo sapiens	243-250
15248214-11	2004	Specific inhibitors of MAPK/ERK-1/2 kinases and p38 MAPK significantly reduced the production of TNFalpha and IL-1beta by rsCD154 plus IFNgamma-stimulated CD14+ synovial cells, and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients.	rscd154	122-129	interleukin 1 beta	Homo sapiens	110-118
15016613-6	2004	Addition of 10 ng/ml IL-1beta to the serosal surface of injured tissues caused a significant increase in TER (P &lt; 0.05) that was inhibited by pretreatment with NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	163-169	interleukin 1 beta	Homo sapiens	21-29
14967525-4	2004	The highest adsorption value of IL-1 beta was 150 ng g(-1) for a mesoporous carbon with surface area around 900 m(2)g(-1) and pore volume around 1.3 cm(3)g(-1).	Carbon	76-82	interleukin 1 beta	Homo sapiens	32-41
15194470-11	2004	In addition, 17beta-estradiol selectively inhibited the Tat-induced expression of IL-1beta.	Estradiol	13-29	interleukin 1 beta	Homo sapiens	82-90
15115662-1	2004	cAMP significantly inhibits IL-1beta+IFNgamma-induced iNOS gene expression in hepatocytes, but the signaling pathways responsible for the effect are not known.	Cyclic AMP	0-4	interleukin 1 beta	Homo sapiens	28-36
15115662-0	2004	JNK signaling involved in the effects of cyclic AMP on IL-1beta plus IFNgamma-induced inducible nitric oxide synthase expression in hepatocytes.	Cyclic AMP	41-51	interleukin 1 beta	Homo sapiens	55-63
15301855-0	2004	Regeneration and tolerance factor modulates the effect of adenosine triphosphate-induced interleukin 1 beta secretion in human macrophages.	Adenosine Triphosphate	58-80	interleukin 1 beta	Homo sapiens	89-107
15115662-6	2004	Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation.	Nitrites	75-82	interleukin 1 beta	Homo sapiens	49-57
15115662-6	2004	Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation.	Cyclic AMP	198-202	interleukin 1 beta	Homo sapiens	49-57
15115662-6	2004	Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation.	Nitrites	206-213	interleukin 1 beta	Homo sapiens	49-57
15115662-7	2004	We conclude that JNK signaling plays an important role in the inhibitory effects of cAMP on IL-1beta+IFNgamma-induced iNOS gene expression in cultured hepatocytes.	Cyclic AMP	84-88	interleukin 1 beta	Homo sapiens	92-100
15220194-8	2004	Similarly, 1 micromol/l of the mitogen-activated protein kinase/ERK kinase 1/2 inhibitor PD098059 or 1 micromol/l of the l-type Ca(2+) channel blocker nimodipine prevented glucose- and IL-1beta-induced ERK activation, beta-cell apoptosis, and impaired function.	Nimodipine	151-161	interleukin 1 beta	Homo sapiens	185-193
15220194-8	2004	Similarly, 1 micromol/l of the mitogen-activated protein kinase/ERK kinase 1/2 inhibitor PD098059 or 1 micromol/l of the l-type Ca(2+) channel blocker nimodipine prevented glucose- and IL-1beta-induced ERK activation, beta-cell apoptosis, and impaired function.	Glucose	172-179	interleukin 1 beta	Homo sapiens	185-193
15220194-9	2004	Finally, islet release of IL-1beta in response to high glucose could be abrogated by nimodipine, NN414, or PD098059.	Glucose	55-62	interleukin 1 beta	Homo sapiens	26-34
15220194-9	2004	Finally, islet release of IL-1beta in response to high glucose could be abrogated by nimodipine, NN414, or PD098059.	Nimodipine	85-95	interleukin 1 beta	Homo sapiens	26-34
15220194-9	2004	Finally, islet release of IL-1beta in response to high glucose could be abrogated by nimodipine, NN414, or PD098059.	NN 414	97-102	interleukin 1 beta	Homo sapiens	26-34
15220194-10	2004	Thus, in human islets, glucose- and IL-1beta-induced beta-cell secretory dysfunction and apoptosis are Ca(2+) influx and ERK dependent and can be prevented by the beta-cell selective potassium channel opener NN414.	NN 414	208-213	interleukin 1 beta	Homo sapiens	36-44
15301855-2	2004	Recently, it has been demonstrated that the interaction of adenosine triphosphate (ATP) with the P2X7 purinoceptor induces the secretion of IL-1 beta and initiates the inflammatory response.	Adenosine Triphosphate	83-86	interleukin 1 beta	Homo sapiens	140-149
15301855-3	2004	In these experiments, that the addition of ATP to macrophages was found to induce P2X7 activation and secretion of IL-1 beta.	Adenosine Triphosphate	43-46	interleukin 1 beta	Homo sapiens	115-124
15301855-2	2004	Recently, it has been demonstrated that the interaction of adenosine triphosphate (ATP) with the P2X7 purinoceptor induces the secretion of IL-1 beta and initiates the inflammatory response.	Adenosine Triphosphate	59-81	interleukin 1 beta	Homo sapiens	140-149
15202003-0	2004	Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite.	erionite	121-129	interleukin 1 beta	Homo sapiens	0-17
15202003-5	2004	Both IL-1beta and TNF-alpha were demonstrated to enhance erionite-induced transformation of the immortalised, non-tumorigenic human mesothelial cell line (MeT-5A) in vitro.	erionite	57-65	interleukin 1 beta	Homo sapiens	5-13
15220194-2	2004	The underlying causes, beta-cell apoptosis and impaired secretory function, seem to be partly mediated by macrophage production of interleukin (IL)-1beta and/or high-glucose-induced beta-cell production of IL-1beta.	Glucose	166-173	interleukin 1 beta	Homo sapiens	206-214
15532722-8	2004	Both the fever and the increased levels of IL-1beta, IL-6, and TNF-alpha in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with either PDTC, Pyri, NAC, or Cur.	pyrrolidine dithiocarbamic acid	183-187	interleukin 1 beta	Homo sapiens	43-51
15220194-4	2004	Therefore, we studied the effect of diazoxide and of the novel potassium channel opener NN414, selective for the beta-cell potassium channel SUR1/Kir6.2, on glucose- and IL-1beta-induced apoptosis and impaired function in human beta-cells.	NN 414	88-93	interleukin 1 beta	Homo sapiens	170-178
15220194-6	2004	The deleterious effects of glucose and IL-1beta were blocked by 200 micromol/l diazoxide as well as by 3 and 30 micromol/l NN414.	Diazoxide	79-88	interleukin 1 beta	Homo sapiens	39-47
15220194-6	2004	The deleterious effects of glucose and IL-1beta were blocked by 200 micromol/l diazoxide as well as by 3 and 30 micromol/l NN414.	NN 414	123-128	interleukin 1 beta	Homo sapiens	39-47
15220194-7	2004	By Western blotting with phosphospecific antibodies, glucose and IL-1beta were shown to activate the extracellular signal-regulated kinase (ERK) 1/2, an effect that was abrogated by 3 micromol/l NN414.	NN 414	195-200	interleukin 1 beta	Homo sapiens	65-73
15220194-8	2004	Similarly, 1 micromol/l of the mitogen-activated protein kinase/ERK kinase 1/2 inhibitor PD098059 or 1 micromol/l of the l-type Ca(2+) channel blocker nimodipine prevented glucose- and IL-1beta-induced ERK activation, beta-cell apoptosis, and impaired function.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	89-97	interleukin 1 beta	Homo sapiens	185-193
15240608-1	2004	Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNFalpha, IL-1beta, and IL-6 and potentiate the expression of the antiinflammatory cytokine IL-10.	Testosterone	91-103	interleukin 1 beta	Homo sapiens	175-183
15240608-3	2004	Compared with placebo, testosterone induced reductions in TNFalpha (-3.1 +/- 8.3 vs. 1.3 +/- 5.2 pg/ml; P = 0.01) and IL-1beta (-0.14 +/- 0.32 vs. 0.18 +/- 0.55 pg/ml; P = 0.08) and an increase in IL-10 (0.33 +/- 1.8 vs. -1.1 +/- 3.0 pg/ml; P = 0.01); the reductions of TNFalpha and IL-1beta were positively correlated (r(S) = 0.588; P = 0.003).	Testosterone	23-35	interleukin 1 beta	Homo sapiens	118-126
15240608-3	2004	Compared with placebo, testosterone induced reductions in TNFalpha (-3.1 +/- 8.3 vs. 1.3 +/- 5.2 pg/ml; P = 0.01) and IL-1beta (-0.14 +/- 0.32 vs. 0.18 +/- 0.55 pg/ml; P = 0.08) and an increase in IL-10 (0.33 +/- 1.8 vs. -1.1 +/- 3.0 pg/ml; P = 0.01); the reductions of TNFalpha and IL-1beta were positively correlated (r(S) = 0.588; P = 0.003).	Testosterone	23-35	interleukin 1 beta	Homo sapiens	283-291
15532722-8	2004	Both the fever and the increased levels of IL-1beta, IL-6, and TNF-alpha in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with either PDTC, Pyri, NAC, or Cur.	pyrithione	189-193	interleukin 1 beta	Homo sapiens	43-51
12898179-4	2004	Celecoxib suppressed proinflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta) induced augmentation of the gelatinolytic activity on zymography.	Celecoxib	0-9	interleukin 1 beta	Homo sapiens	80-97
15324573-4	2004	This study aimed to investigate the effects of colchicine on the synthesis and excretion of cytokines transforming growth factor-beta1 (TGF-beta1), interleukin-1beta (IL-1beta) and extracellular matrix (collagen III, collagen IV) in human renal fibroblast.	Colchicine	47-57	interleukin 1 beta	Homo sapiens	148-165
15324573-4	2004	This study aimed to investigate the effects of colchicine on the synthesis and excretion of cytokines transforming growth factor-beta1 (TGF-beta1), interleukin-1beta (IL-1beta) and extracellular matrix (collagen III, collagen IV) in human renal fibroblast.	Colchicine	47-57	interleukin 1 beta	Homo sapiens	167-175
15272234-0	2004	Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes.	Dinoprostone	73-89	interleukin 1 beta	Homo sapiens	0-17
15272234-4	2004	IL-1beta-related MMP-2 expression was found to be dependent on prostaglandin E2 (PGE2) production.	Dinoprostone	63-79	interleukin 1 beta	Homo sapiens	0-8
15324573-11	2004	IL-1beta mRNA and protein were both up-regulated by colchicine.	Colchicine	52-62	interleukin 1 beta	Homo sapiens	0-8
15272234-4	2004	IL-1beta-related MMP-2 expression was found to be dependent on prostaglandin E2 (PGE2) production.	Dinoprostone	81-85	interleukin 1 beta	Homo sapiens	0-8
15324573-13	2004	CONCLUSION: (1) The expression of TGF-beta1 mRNA and the excretion of TGF-beta1 protein in the fibroblasts was significantly suppressed by colchicine, while the expression of IL-1beta mRNA and the excretion of IL-1beta protein were enhanced.	Colchicine	139-149	interleukin 1 beta	Homo sapiens	210-218
15272234-7	2004	Taken together, these results demonstrated that IL-1beta induces MMP-2 expression through the PGE2-dependent mechanism in human chondrocytes.	Dinoprostone	94-98	interleukin 1 beta	Homo sapiens	48-56
15192144-6	2004	Externalization of mature IL-1 beta and caspase-1 together with lysosomal proteins is then facilitated by extracellular ATP.	Adenosine Triphosphate	120-123	interleukin 1 beta	Homo sapiens	26-35
15187156-4	2004	The adenosine analog 5"-N-ethylcarboxamidoadenosine (NECA) (10 microM) increased mRNA expression of IL-1beta, IL-3, IL-4, IL-8, and IL-13, but not IL-2 and IFN-gamma.	Adenosine	4-13	interleukin 1 beta	Homo sapiens	100-108
15187156-4	2004	The adenosine analog 5"-N-ethylcarboxamidoadenosine (NECA) (10 microM) increased mRNA expression of IL-1beta, IL-3, IL-4, IL-8, and IL-13, but not IL-2 and IFN-gamma.	Adenosine-5'-(N-ethylcarboxamide)	21-51	interleukin 1 beta	Homo sapiens	100-108
15187156-4	2004	The adenosine analog 5"-N-ethylcarboxamidoadenosine (NECA) (10 microM) increased mRNA expression of IL-1beta, IL-3, IL-4, IL-8, and IL-13, but not IL-2 and IFN-gamma.	Adenosine-5'-(N-ethylcarboxamide)	53-57	interleukin 1 beta	Homo sapiens	100-108
15007070-1	2004	Stable expression of human groups IIA and X secreted phospholipases A(2) (hGIIA and hGX) in CHO-K1 and HEK293 cells leads to serum- and interleukin-1beta-promoted arachidonate release.	Arachidonic Acid	163-175	interleukin 1 beta	Homo sapiens	136-153
15188490-3	2004	HHcy unleashes mediators of inflammation such as NFkappaB, IL-1beta, IL-6, and IL-8, increases production of intracellular superoxide anion causing oxidative stress and reducing intracellular level of nitric oxide (NO), and induces endoplasmic reticulum (ER) stress which can explain many processes of Hcy-promoted cell injury such as apoptosis, fat accumulation, and inflammation.	Homocysteine	1-4	interleukin 1 beta	Homo sapiens	59-67
15007070-7	2004	Additional results show that the interleukin-1beta-dependent release of arachidonate is promoted by secreted phospholipase A(2) expression and is completely dependent on cytosolic (group IVA) phospholipase A(2).	Arachidonic Acid	72-84	interleukin 1 beta	Homo sapiens	33-50
14749204-8	2004	In contrast, IL-1beta-stimulated glucose transport is accompanied by increased expression and membrane incorporation of GLUT1 and -6 and depends upon activation of PKC and p38 MAP kinase.	Glucose	33-40	interleukin 1 beta	Homo sapiens	13-21
15155187-3	2004	In the present study we investigated the effects of MXF on the production of proinflammatory cytokines (i.e., IL-8, TNF-alpha, and IL-1beta) by activated human peripheral blood monocytes and THP-1 cells and analyzed the effects of the drug on the major signal transduction pathways associated with inflammation: NF-kappaB and the mitogen-activated protein kinases ERK and c-Jun N-terminal kinase (JNK).	Moxifloxacin	52-55	interleukin 1 beta	Homo sapiens	131-139
14749204-4	2004	The objective of the present study was to determine differences in molecular mechanisms regulating glucose transport in chondrocytes stimulated with the anabolic transforming growth factor-beta1 (TGF-beta1) vs. the catabolic and proinflammatory cytokine IL-1beta.	Glucose	99-106	interleukin 1 beta	Homo sapiens	254-262
14749204-5	2004	Both TGF-beta1 and IL-1beta accelerate glucose transport in chondrocytes.	Glucose	39-46	interleukin 1 beta	Homo sapiens	19-27
14749204-6	2004	Although both IL-1beta and TGF-beta1 enhance glucose transport in chondrocytes to a similar magnitude, IL-1beta induces significantly higher levels of lactate.	Glucose	45-52	interleukin 1 beta	Homo sapiens	14-22
14749204-6	2004	Although both IL-1beta and TGF-beta1 enhance glucose transport in chondrocytes to a similar magnitude, IL-1beta induces significantly higher levels of lactate.	Lactic Acid	151-158	interleukin 1 beta	Homo sapiens	103-111
15183150-4	2004	Human recombinant IL-1beta stimulated PGE(2) production and shifted the cilomilast concentration-dependence curve to the left in both assay systems, indicating increased sensitivity to cilomilast.	Dinoprostone	38-44	interleukin 1 beta	Homo sapiens	18-26
14960485-7	2004	Moreover, treatment of cells with PD98059, an inhibitor of ERK1/2 signaling, inhibited the stimulation of HIF-1 alpha protein expression and VEGF secretion by IL-1 beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	34-41	interleukin 1 beta	Homo sapiens	159-168
15149889-0	2004	Simvastatin reduces interleukin-1beta secretion by peripheral blood mononuclear cells in patients with essential hypertension.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	20-37
15149889-3	2004	We studied whether individuals with essential hypertension have increased interleukin-1beta (IL-1beta) secretion in peripheral blood mononuclear cells (PBMCs) and whether treatment with simvastatin lowered IL-1beta secretion by PBMCs.	Simvastatin	186-197	interleukin 1 beta	Homo sapiens	206-214
15149889-9	2004	Simvastatin treatment had a significant effect of decreasing IL-1beta [668+/-98 vs. 923+/-67 pg/ml; P&lt;0.05] secretion in PBMCs.	Simvastatin	0-11	interleukin 1 beta	Homo sapiens	61-69
15188375-1	2004	OBJECTIVE: Significant variation in interleukin-1 beta (IL-1 beta) protein secretion between subjects has been observed when using a lipopolysaccharide (LPS)/ATP-mediated ex vivo blood stimulation assay.	Adenosine Triphosphate	158-161	interleukin 1 beta	Homo sapiens	36-54
15188375-1	2004	OBJECTIVE: Significant variation in interleukin-1 beta (IL-1 beta) protein secretion between subjects has been observed when using a lipopolysaccharide (LPS)/ATP-mediated ex vivo blood stimulation assay.	Adenosine Triphosphate	158-161	interleukin 1 beta	Homo sapiens	56-65
15156569-0	2004	Platelet-derived growth factor-induced arachidonic acid release for enhancement of prostaglandin E(2) synthesis in human gingival fibroblasts pretreated with interleukin-1beta.	Arachidonic Acid	39-55	interleukin 1 beta	Homo sapiens	158-175
14717657-7	2004	Although addition of LPS (lipopolysaccharide) and glucose showed no significant enhancing effect, addition of IL-1beta or TNF-alpha (tumour necrosis factor-alpha) with MTX to bronchial epithelial cells showed a significant augmenting effect.	Methotrexate	168-171	interleukin 1 beta	Homo sapiens	110-118
15135313-2	2004	In this study, we demonstrate that resveratrol enhanced TNF-alpha, IL-12 and IL-1beta production from LPS activated phorbol myristate acetate (PMA) differentiated THP-1 human macrophages.	Resveratrol	35-46	interleukin 1 beta	Homo sapiens	77-85
15135313-2	2004	In this study, we demonstrate that resveratrol enhanced TNF-alpha, IL-12 and IL-1beta production from LPS activated phorbol myristate acetate (PMA) differentiated THP-1 human macrophages.	Tetradecanoylphorbol Acetate	116-141	interleukin 1 beta	Homo sapiens	77-85
15135313-4	2004	When macrophages were primed with IFN-gamma, resveratrol suppressed the expression of HLA-ABC, HLA-DR, CD80, CD86 and inhibited production of TNF-alpha, IL-12, IL-6 and IL-1beta induced by LPS.	Resveratrol	45-56	interleukin 1 beta	Homo sapiens	169-177
15156569-0	2004	Platelet-derived growth factor-induced arachidonic acid release for enhancement of prostaglandin E(2) synthesis in human gingival fibroblasts pretreated with interleukin-1beta.	Dinoprostone	83-101	interleukin 1 beta	Homo sapiens	158-175
15156569-6	2004	On the other hand, in the HGF pre-stimulated with interleukin-1beta (IL-1beta), PDGF clearly increased PGE(2) release.	Prostaglandins E	103-106	interleukin 1 beta	Homo sapiens	50-67
15156569-6	2004	On the other hand, in the HGF pre-stimulated with interleukin-1beta (IL-1beta), PDGF clearly increased PGE(2) release.	Prostaglandins E	103-106	interleukin 1 beta	Homo sapiens	69-77
15156569-8	2004	In the HGF pretreated with IL-1beta, arachidonic acid strongly enhanced PGE(2) release and COX-2 mRNA expression.	Arachidonic Acid	37-53	interleukin 1 beta	Homo sapiens	27-35
15156569-8	2004	In the HGF pretreated with IL-1beta, arachidonic acid strongly enhanced PGE(2) release and COX-2 mRNA expression.	Prostaglandins E	72-75	interleukin 1 beta	Homo sapiens	27-35
15156569-9	2004	These results suggest that PDGF stimulates arachidonic acid release by the increase in [Ca(2+)](i) via tyrosine kinase activation, and which contributes to PGE(2) production via COX-2 expression in HGF primed with IL-1beta.	Arachidonic Acid	43-59	interleukin 1 beta	Homo sapiens	214-222
15020655-1	2004	We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-1beta] secretion by T cells, macrophages, or intestinal epithelial cells.	Disaccharides	28-41	interleukin 1 beta	Homo sapiens	254-262
15020655-1	2004	We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-1beta] secretion by T cells, macrophages, or intestinal epithelial cells.	Disaccharides	43-45	interleukin 1 beta	Homo sapiens	254-262
14872092-1	2004	Prostaglandin (PG) E(2) induces dendritic cell maturation in cooperation with proinflammatory cytokines [such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta].	Dinoprostone	0-23	interleukin 1 beta	Homo sapiens	151-173
14762100-3	2004	Here, we demonstrate that exposure of neutrophil (PMN)/human umbilical vein endothelial cell (HUVEC) cocultures to aspirin and NCX-4016 triggers ATL formation and inhibits cell-to-cell adhesion induced by endotoxin (LPS) and interleukin (IL)-1beta by 70 to 90%.	Aspirin	115-122	interleukin 1 beta	Homo sapiens	225-247
15158019-6	2004	Interestingly, chemotaxis of U937 cells, in response to astroglial-exposed media, is reduced when astroglia are chronically (9 days) exposed to 50 mM ethanol before stimulation with LPS + IL-1beta.	Ethanol	150-157	interleukin 1 beta	Homo sapiens	188-196
15196696-6	2004	By the addition of an NO donor together with IL-1beta, PGE(2) formation could be stimulated from iNOS -/- islets.	Prostaglandins E	55-58	interleukin 1 beta	Homo sapiens	45-53
15296944-6	2004	EGCG reduced the stimulation of p54 JNK/SAPK phosphorylation by IL-1beta but did not affect p38 MAPK phosphorylation, the degradation of IkappaB or the activating phosphorylation of NFkappaB.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	64-72
15158019-7	2004	Furthermore, we observed that LPS + IL-1beta-stimulated CXCL10 production is inhibited in human A172 astroglia exposed to chronic 50 mM ethanol.	Ethanol	136-143	interleukin 1 beta	Homo sapiens	36-44
15023995-5	2004	15d-PGJ(2) and TRO suppressed IL-1beta-induced activation of the mPGES-1 promoter.	15d-pgj	0-7	interleukin 1 beta	Homo sapiens	30-38
15141093-1	2004	High concentrations of glucose induce beta cell production of IL-1beta, leading to impaired beta cell function and apoptosis in human pancreatic islets.	Glucose	23-30	interleukin 1 beta	Homo sapiens	62-70
15141093-9	2004	These findings demonstrate expression of IL-1Ra in the human beta cell, providing localized protection against leptin- and glucose-induced islet IL-1beta.	Glucose	123-130	interleukin 1 beta	Homo sapiens	145-153
15023995-0	2004	Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.	Dinoprostone	118-134	interleukin 1 beta	Homo sapiens	72-89
15033544-10	2004	TNF-alpha and IL-1beta presented a maximum response after 1h treatment, while IL-6 and IL-8 maximum response was after 3h treatment.	Hydrogen	58-60	interleukin 1 beta	Homo sapiens	14-22
15033544-16	2004	These data indicate that, Cd-induced TNF-alpha and IL-1beta, that probably, activate AP-1 transcription factor and IL-6 and IL-8 were induced.	Cadmium	26-28	interleukin 1 beta	Homo sapiens	51-59
15100360-8	2004	Characterization of HA synthesis by addition of [(3)H]-glucosamine to cells at the time of stimulation demonstrated that increased HA in response to IL-1 was most apparent in the culture medium, while BMP-7 led to an increase in cell associated HA.	[(3)h]-glucosamine	48-66	interleukin 1 beta	Homo sapiens	149-153
15051519-0	2004	Methylglyoxal induces oxidative stress-dependent cell injury and up-regulation of interleukin-1beta and nerve growth factor in cultured hippocampal neuronal cells.	Pyruvaldehyde	0-13	interleukin 1 beta	Homo sapiens	82-99
15171815-1	2004	Lipoxin A4 (LXA4) is a potent eicosanoid that inhibits IL-1beta-induced activation of human fibroblast like synoviocytes (FLS) via the ALX4 receptor.	lipoxin A4	0-10	interleukin 1 beta	Homo sapiens	55-63
15171815-1	2004	Lipoxin A4 (LXA4) is a potent eicosanoid that inhibits IL-1beta-induced activation of human fibroblast like synoviocytes (FLS) via the ALX4 receptor.	lipoxin A4	12-16	interleukin 1 beta	Homo sapiens	55-63
15171815-1	2004	Lipoxin A4 (LXA4) is a potent eicosanoid that inhibits IL-1beta-induced activation of human fibroblast like synoviocytes (FLS) via the ALX4 receptor.	Eicosanoids	30-40	interleukin 1 beta	Homo sapiens	55-63
15146435-10	2004	In addition, BCP crystals were found to up-regulate the proinflammatory cytokine IL-1beta (maximal at 8 hours).	bcp	13-16	interleukin 1 beta	Homo sapiens	81-89
15146435-11	2004	The induction of both COX-2 and IL-1beta by BCP crystals was attenuated when the cells were treated with phosphocitrate.	bcp	44-47	interleukin 1 beta	Homo sapiens	32-40
15146435-11	2004	The induction of both COX-2 and IL-1beta by BCP crystals was attenuated when the cells were treated with phosphocitrate.	phosphocitrate	105-119	interleukin 1 beta	Homo sapiens	32-40
15146435-12	2004	CONCLUSION: These findings indicate that BCP crystals may be an important amplifier of PGE(2) production through induction of the COX enzymes and the proinflammatory cytokine IL-1beta.	bcp	41-44	interleukin 1 beta	Homo sapiens	175-183
15146435-12	2004	CONCLUSION: These findings indicate that BCP crystals may be an important amplifier of PGE(2) production through induction of the COX enzymes and the proinflammatory cytokine IL-1beta.	Dinoprostone	87-93	interleukin 1 beta	Homo sapiens	175-183
15209355-1	2004	Interleukin-1beta (IL-1beta), a cytokine involved in homeostatic processes such as the immune system and inflammatory reactions, is a potent inducer of nitric oxide.	Nitric Oxide	152-164	interleukin 1 beta	Homo sapiens	0-17
15209355-1	2004	Interleukin-1beta (IL-1beta), a cytokine involved in homeostatic processes such as the immune system and inflammatory reactions, is a potent inducer of nitric oxide.	Nitric Oxide	152-164	interleukin 1 beta	Homo sapiens	19-27
15124023-4	2004	Prevention of PBEF translation with an antisense oligonucleotide completely abrogates the inhibitory effects of LPS, IL-1, GM-CSF, IL-8, and TNF-alpha on neutrophil apoptosis.	Oligonucleotides	49-64	interleukin 1 beta	Homo sapiens	117-121
15067222-1	2004	Interleukin-1beta (IL-1beta) has been recognized as a potent stimulus for the synthesis of prostaglandin (PG), which has been implicated in inflammatory responses of the airways.	Prostaglandins	91-104	interleukin 1 beta	Homo sapiens	0-17
15067222-1	2004	Interleukin-1beta (IL-1beta) has been recognized as a potent stimulus for the synthesis of prostaglandin (PG), which has been implicated in inflammatory responses of the airways.	Prostaglandins	91-104	interleukin 1 beta	Homo sapiens	19-27
15067222-1	2004	Interleukin-1beta (IL-1beta) has been recognized as a potent stimulus for the synthesis of prostaglandin (PG), which has been implicated in inflammatory responses of the airways.	Prostaglandins	106-108	interleukin 1 beta	Homo sapiens	0-17
15067222-1	2004	Interleukin-1beta (IL-1beta) has been recognized as a potent stimulus for the synthesis of prostaglandin (PG), which has been implicated in inflammatory responses of the airways.	Prostaglandins	106-108	interleukin 1 beta	Homo sapiens	19-27
15067222-2	2004	However, the mechanisms underlying IL-1beta-induced cyclooxygenase (COX) expression and PGE(2) synthesis via activation of p42/p44 and p38 mitogen-activated protein kinases (MAPKs) in human tracheal smooth muscle cells (HTSMCs) are not completely understood.	Dinoprostone	88-94	interleukin 1 beta	Homo sapiens	35-43
15067222-3	2004	We found that IL-1beta increased COX-2 expression and PGE(2) synthesis in time- and concentration-dependent manners.	Dinoprostone	54-60	interleukin 1 beta	Homo sapiens	14-22
15067222-4	2004	Both specific phosphatidylcholine-phospholipase C inhibitor (D609) and protein kinase C inhibitor (GF109203X) attenuated IL-1beta-induced responses in HTSMCs.	tricyclodecane-9-yl-xanthogenate	61-65	interleukin 1 beta	Homo sapiens	121-129
15067222-4	2004	Both specific phosphatidylcholine-phospholipase C inhibitor (D609) and protein kinase C inhibitor (GF109203X) attenuated IL-1beta-induced responses in HTSMCs.	bisindolylmaleimide I	99-108	interleukin 1 beta	Homo sapiens	121-129
15067222-5	2004	IL-1beta-induced COX-2 expression and PGE(2) synthesis were also inhibited by an inhibitor of MEK1/2 (PD98059) and inhibitors of p38 MAPK (SB203580 and SB202190), respectively, suggesting the involvement of p42/p44 and p38 MAPKs in these responses.	Prostaglandins E	38-41	interleukin 1 beta	Homo sapiens	0-8
15067222-5	2004	IL-1beta-induced COX-2 expression and PGE(2) synthesis were also inhibited by an inhibitor of MEK1/2 (PD98059) and inhibitors of p38 MAPK (SB203580 and SB202190), respectively, suggesting the involvement of p42/p44 and p38 MAPKs in these responses.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	102-109	interleukin 1 beta	Homo sapiens	0-8
15067222-8	2004	IL-1beta-induced COX-2 expression and PGE(2) synthesis were inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate.	Prostaglandins E	38-42	interleukin 1 beta	Homo sapiens	0-8
15067222-8	2004	IL-1beta-induced COX-2 expression and PGE(2) synthesis were inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	97-123	interleukin 1 beta	Homo sapiens	0-8
15067222-9	2004	These findings suggest that the expression of COX-2 is correlated with the release of PGE(2) from IL-1beta-challenged HTSMCs, which is mediated, at least in part, through p42/p44 and p38 MAPKs and NF-kappaB signaling pathways in HTSMCs.	Prostaglandins E	86-89	interleukin 1 beta	Homo sapiens	98-106
14747610-5	2004	All cAMP-elevating drugs tested promoted the phosphorylation of cAMP response element-binding protein (CREB), activated a cAMP response element (CRE)-driven luciferase reporter gene, and suppressed both granulocyte/macrophage colony-stimulating factor (GM-CSF) generation and [(3)H]arachidonic acid (AA) release in response to interleukin-1beta and monocyte chemotactic protein (MCP)-1, respectively.	Cyclic AMP	4-8	interleukin 1 beta	Homo sapiens	327-344
15113942-0	2004	Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells.	epigallocatechin gallate	0-26	interleukin 1 beta	Homo sapiens	69-78
15113942-0	2004	Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells.	Polyphenols	48-58	interleukin 1 beta	Homo sapiens	69-78
15113942-4	2004	We therefore hypothesized that EGCG inhibits IL-1 beta-mediated activation of the NF-kappa B pathway.	epigallocatechin gallate	31-35	interleukin 1 beta	Homo sapiens	45-54
15113942-6	2004	The EGCG markedly inhibited IL-1 beta-mediated IL-1 beta receptor-associated kinase (IRAK) degradation and the signaling events downstream from IRAK degradation: IKK activation, I kappa B alpha degradation, and NF-kappa B activation.	epigallocatechin gallate	4-8	interleukin 1 beta	Homo sapiens	28-37
15113942-9	2004	Therefore, the green tea polyphenol EGCG is a potent inhibitor of IL-1 beta signal transduction in vitro.	Polyphenols	25-35	interleukin 1 beta	Homo sapiens	66-75
15113942-9	2004	Therefore, the green tea polyphenol EGCG is a potent inhibitor of IL-1 beta signal transduction in vitro.	epigallocatechin gallate	36-40	interleukin 1 beta	Homo sapiens	66-75
15140579-8	2004	We also showed that pretreatment with wortmannin augmented LPS-induced endogenous IL-1beta gene expression in monocytic THP-1 cells.	Wortmannin	38-48	interleukin 1 beta	Homo sapiens	82-90
15051633-7	2004	(1) Although mRNA levels of IL-1alpha and IL-1beta were markedly reduced in PBMCs from CAD patients after 6 months of simvastatin (20 mg/d, n=15) and atorvastatin (80 mg/d, n=15) therapy, the reduction in IL-1 receptor antagonist (IL-1Ra) was more modest.	Simvastatin	118-129	interleukin 1 beta	Homo sapiens	42-50
14998552-7	2004	SB203580 and PD98059 decreased LPS-induced gene expression of IL-1beta and IL-6.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	62-70
14998552-7	2004	SB203580 and PD98059 decreased LPS-induced gene expression of IL-1beta and IL-6.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	interleukin 1 beta	Homo sapiens	62-70
14976356-9	2004	However, the type 1-associated parameters (CD8(+) cells, macrophages, IFN-gamma, TNF-alpha, and IL-1 beta) that are induced in the PLN by streptozotocin were less pronounced in the ALN.	Streptozocin	138-152	interleukin 1 beta	Homo sapiens	96-105
15063774-2	2004	In this work, we demonstrated that oligochitosan had an in vitro stimulatory effect on the release of tumor necrosis factor-alpha and interleukin-1 beta in macrophages.	oligochitosan	35-48	interleukin 1 beta	Homo sapiens	134-152
15015204-10	2004	In the case of Ni(II), potentiation of TNFalpha, IL1beta, and IL6 ranged from 200% for TNFalpha to over 1200% for IL6.	Nickel(2+)	15-21	interleukin 1 beta	Homo sapiens	49-56
15051633-7	2004	(1) Although mRNA levels of IL-1alpha and IL-1beta were markedly reduced in PBMCs from CAD patients after 6 months of simvastatin (20 mg/d, n=15) and atorvastatin (80 mg/d, n=15) therapy, the reduction in IL-1 receptor antagonist (IL-1Ra) was more modest.	Atorvastatin	150-162	interleukin 1 beta	Homo sapiens	42-50
15003325-8	2004	Furthermore, a significant increase in IL-1beta and TNF-alpha generation was observed in the NO2-exposed cells.	Nitrogen Dioxide	93-96	interleukin 1 beta	Homo sapiens	39-47
15067080-2	2004	Although ATP as a second stimulus potently promotes IL-1 beta maturation and release via P2X(7) receptor activation, millimolar ATP concentrations are needed.	Adenosine Triphosphate	9-12	interleukin 1 beta	Homo sapiens	52-61
15067080-6	2004	IL-1 beta release and cell permeability are suppressed by pretreatment with the P2X(7) inhibitors oxidized ATP, KN04, and KN62.	Adenosine Triphosphate	107-110	interleukin 1 beta	Homo sapiens	0-9
15067080-6	2004	IL-1 beta release and cell permeability are suppressed by pretreatment with the P2X(7) inhibitors oxidized ATP, KN04, and KN62.	KN 04	112-116	interleukin 1 beta	Homo sapiens	0-9
15023863-4	2004	IL-1 beta evoked the release of GM-CSF from HASM cells, which was suppressed by PGE(2), 16,16-dimethyl PGE(2) (nonselective), misoprostol (EP(2)/EP(3)-selective), ONO-AE1-259 and butaprost (both EP(2)-selective) with pIC(50) values of 8.61, 7.13, 5.64, 8.79 and 5.43, respectively.	Prostaglandins E	80-83	interleukin 1 beta	Homo sapiens	0-9
15033450-5	2004	EGCG also inhibited the IL-1beta-induced induction of VCAM-1 expression.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	24-32
15019843-2	2004	We have previously shown that TCDD-stimulated AhR-dependent IL-1beta expression in human keratinocytes is due to posttranscriptional regulation involving mRNA stabilization.	Polychlorinated Dibenzodioxins	30-34	interleukin 1 beta	Homo sapiens	60-68
15019843-3	2004	Since TCDD activates a variety of cellular signaling pathways such as PKC, JNK, and ERK, we investigated these pathways to determine their roles in TCDD-stimulated IL-1beta expression in the human keratinocyte cell line SCC-12F.	Polychlorinated Dibenzodioxins	6-10	interleukin 1 beta	Homo sapiens	164-172
15019843-3	2004	Since TCDD activates a variety of cellular signaling pathways such as PKC, JNK, and ERK, we investigated these pathways to determine their roles in TCDD-stimulated IL-1beta expression in the human keratinocyte cell line SCC-12F.	Polychlorinated Dibenzodioxins	148-152	interleukin 1 beta	Homo sapiens	164-172
15019843-6	2004	Thus, both the ERK and JNK MAPK pathways are necessary for IL-1beta expression in TCDD-stimulated human keratinocytes, however, they act at different levels to modulate IL-1beta expression.	Polychlorinated Dibenzodioxins	82-86	interleukin 1 beta	Homo sapiens	59-67
15077295-3	2004	CRH- and interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production from 10 fresh rheumatoid arthritis (RA) synovial tissue (ST) explants was quantified using a competitive enzyme-linked immunosorbent assay.	Dinoprostone	48-66	interleukin 1 beta	Homo sapiens	9-27
15077295-3	2004	CRH- and interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production from 10 fresh rheumatoid arthritis (RA) synovial tissue (ST) explants was quantified using a competitive enzyme-linked immunosorbent assay.	Dinoprostone	48-66	interleukin 1 beta	Homo sapiens	29-38
15077295-3	2004	CRH- and interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production from 10 fresh rheumatoid arthritis (RA) synovial tissue (ST) explants was quantified using a competitive enzyme-linked immunosorbent assay.	Dinoprostone	68-74	interleukin 1 beta	Homo sapiens	9-27
15077295-3	2004	CRH- and interleukin-1 beta (IL-1 beta)-induced prostaglandin E(2) (PGE(2)) production from 10 fresh rheumatoid arthritis (RA) synovial tissue (ST) explants was quantified using a competitive enzyme-linked immunosorbent assay.	Dinoprostone	68-74	interleukin 1 beta	Homo sapiens	29-38
15077295-8	2004	Costimulation of RA ST with CRH and IL-1 beta significantly augmented (P = 0.036) the effects on PGE(2) production additively over 24 hours.	Dinoprostone	97-103	interleukin 1 beta	Homo sapiens	36-45
15077295-9	2004	We demonstrated that selective COX-2 inhibitors prevent the induction of PGE(2) by both CRH and IL-1 beta.	Prostaglandins E	73-76	interleukin 1 beta	Homo sapiens	96-105
15282113-3	2004	Results from a previous study in our laboratory, in the human A172 astroglial cell line, revealed that induction of iNOS activity by tumor necrosis factor-alpha + interferon-gamma + interleukin-1 beta was inhibited by 24-h exposure to a high ethanol concentration (200 mM), but enhanced by 50 mM ethanol.	Ethanol	242-249	interleukin 1 beta	Homo sapiens	182-200
15282113-3	2004	Results from a previous study in our laboratory, in the human A172 astroglial cell line, revealed that induction of iNOS activity by tumor necrosis factor-alpha + interferon-gamma + interleukin-1 beta was inhibited by 24-h exposure to a high ethanol concentration (200 mM), but enhanced by 50 mM ethanol.	Ethanol	296-303	interleukin 1 beta	Homo sapiens	182-200
15023863-4	2004	IL-1 beta evoked the release of GM-CSF from HASM cells, which was suppressed by PGE(2), 16,16-dimethyl PGE(2) (nonselective), misoprostol (EP(2)/EP(3)-selective), ONO-AE1-259 and butaprost (both EP(2)-selective) with pIC(50) values of 8.61, 7.13, 5.64, 8.79 and 5.43, respectively.	dimethyl pge	94-106	interleukin 1 beta	Homo sapiens	0-9
15023863-4	2004	IL-1 beta evoked the release of GM-CSF from HASM cells, which was suppressed by PGE(2), 16,16-dimethyl PGE(2) (nonselective), misoprostol (EP(2)/EP(3)-selective), ONO-AE1-259 and butaprost (both EP(2)-selective) with pIC(50) values of 8.61, 7.13, 5.64, 8.79 and 5.43, respectively.	Misoprostol	126-137	interleukin 1 beta	Homo sapiens	0-9
15023863-4	2004	IL-1 beta evoked the release of GM-CSF from HASM cells, which was suppressed by PGE(2), 16,16-dimethyl PGE(2) (nonselective), misoprostol (EP(2)/EP(3)-selective), ONO-AE1-259 and butaprost (both EP(2)-selective) with pIC(50) values of 8.61, 7.13, 5.64, 8.79 and 5.43, respectively.	ono-ae1	163-170	interleukin 1 beta	Homo sapiens	0-9
15023863-4	2004	IL-1 beta evoked the release of GM-CSF from HASM cells, which was suppressed by PGE(2), 16,16-dimethyl PGE(2) (nonselective), misoprostol (EP(2)/EP(3)-selective), ONO-AE1-259 and butaprost (both EP(2)-selective) with pIC(50) values of 8.61, 7.13, 5.64, 8.79 and 5.43, respectively.	butaprost	179-188	interleukin 1 beta	Homo sapiens	0-9
14684600-8	2004	PVN catecholamine turnover significantly increased after icv injection of IL-1beta, but not EtOH.	Catecholamines	4-17	interleukin 1 beta	Homo sapiens	74-82
14684600-9	2004	Brain catecholamine depletion due to the neurotoxin 6-hydroxydopamine did not alter the ability of hCG to induce T release, but significantly reversed the inhibitory effect of icv EtOH or IL-1beta on this response.	Oxidopamine	52-69	interleukin 1 beta	Homo sapiens	188-196
14684600-9	2004	Brain catecholamine depletion due to the neurotoxin 6-hydroxydopamine did not alter the ability of hCG to induce T release, but significantly reversed the inhibitory effect of icv EtOH or IL-1beta on this response.	Catecholamines	6-19	interleukin 1 beta	Homo sapiens	188-196
14684600-10	2004	Collectively, these results indicate that icv-injected IL-1beta or EtOH blunts hCG-induced T secretion through a catecholamine-mediated mechanism that does not depend on either peripherally mediated effects or pituitary LH, and that the PVN plays a role in these effects.	Catecholamines	113-126	interleukin 1 beta	Homo sapiens	55-63
15379214-2	2004	Previously we have reported that the inflammatory mediators interleukin-1beta, (IL-1beta) and tumor necrosis factor alpha (TNFalpha) stimulate PGE2 synthesis by inducing mRNA expression of cyclooxygenase-2 (COX-2) in human gingival fibroblasts.	Dinoprostone	143-147	interleukin 1 beta	Homo sapiens	60-78
14973543-7	2004	An intra-articular injection of zymosan, 3 days after Ad5.IL-1/IL-6-Luc, increased Luc.	Zymosan	32-39	interleukin 1 beta	Homo sapiens	58-62
14990538-7	2004	The levels of IL-1beta correlated significantly in a negative manner with FSH, LH, FT and TT in all patients with acute toxoplasmosis (n = 40).	Luteinizing Hormone	79-81	interleukin 1 beta	Homo sapiens	14-22
14990538-7	2004	The levels of IL-1beta correlated significantly in a negative manner with FSH, LH, FT and TT in all patients with acute toxoplasmosis (n = 40).	ft	83-85	interleukin 1 beta	Homo sapiens	14-22
14990538-7	2004	The levels of IL-1beta correlated significantly in a negative manner with FSH, LH, FT and TT in all patients with acute toxoplasmosis (n = 40).	Testosterone	90-92	interleukin 1 beta	Homo sapiens	14-22
15379214-4	2004	The results showed that IL-1beta as well as TNFalpha induced mPGES-1 mRNA and protein expression accompanied by enhanced PGE2 production in gingival fibroblasts.	Dinoprostone	121-125	interleukin 1 beta	Homo sapiens	24-32
15056378-9	2004	The trapping of chemokines by heparinoids reduced the chemotactic activity of islets supernatant from 3.05 +/- 0.27 to 1.2 +/- 0.1 with heparin or pentosan and to 1.72 +/- 0.22 with C8S, and also decreased the TNF-alpha release by human macrophages from 1205 +/- 35 to 1000 +/- 26 (C8S), 250 +/- 21 (heparin) and 320 +/- 19 (pentosan) pg/ml, and IL-1beta from 234 +/- 13 to 151 +/- 5 (C8S), 50 +/- 3 (heparin) and 57 +/- 4 (pentosan) pg/ml.	Heparinoids	30-41	interleukin 1 beta	Homo sapiens	346-354
15056378-9	2004	The trapping of chemokines by heparinoids reduced the chemotactic activity of islets supernatant from 3.05 +/- 0.27 to 1.2 +/- 0.1 with heparin or pentosan and to 1.72 +/- 0.22 with C8S, and also decreased the TNF-alpha release by human macrophages from 1205 +/- 35 to 1000 +/- 26 (C8S), 250 +/- 21 (heparin) and 320 +/- 19 (pentosan) pg/ml, and IL-1beta from 234 +/- 13 to 151 +/- 5 (C8S), 50 +/- 3 (heparin) and 57 +/- 4 (pentosan) pg/ml.	Heparin	30-37	interleukin 1 beta	Homo sapiens	346-354
15379214-5	2004	The anti-inflammatory steroid dexamethasone (DEX) inhibited mPGES-1 mRNA and protein expression as well as PGE2 production induced by IL-1beta or TNFalpha.	Steroids	22-29	interleukin 1 beta	Homo sapiens	134-142
15379214-2	2004	Previously we have reported that the inflammatory mediators interleukin-1beta, (IL-1beta) and tumor necrosis factor alpha (TNFalpha) stimulate PGE2 synthesis by inducing mRNA expression of cyclooxygenase-2 (COX-2) in human gingival fibroblasts.	Dinoprostone	143-147	interleukin 1 beta	Homo sapiens	80-88
15379214-5	2004	The anti-inflammatory steroid dexamethasone (DEX) inhibited mPGES-1 mRNA and protein expression as well as PGE2 production induced by IL-1beta or TNFalpha.	Dexamethasone	30-43	interleukin 1 beta	Homo sapiens	134-142
15146996-8	2004	It was shown that Ticovac and the new Encepur Kinder can induce relatively high amounts of TNF-alpha and lower amounts of IL-1beta.	ticovac	18-25	interleukin 1 beta	Homo sapiens	122-130
15379214-5	2004	The anti-inflammatory steroid dexamethasone (DEX) inhibited mPGES-1 mRNA and protein expression as well as PGE2 production induced by IL-1beta or TNFalpha.	Dexamethasone	45-48	interleukin 1 beta	Homo sapiens	134-142
15379214-5	2004	The anti-inflammatory steroid dexamethasone (DEX) inhibited mPGES-1 mRNA and protein expression as well as PGE2 production induced by IL-1beta or TNFalpha.	Dinoprostone	107-111	interleukin 1 beta	Homo sapiens	134-142
15379214-6	2004	The COX-2 specific inhibitor, celecoxib, in contrast to the nonspecific COX inhibitor, indomethacin, markedly reduced mPGES-1 expression induced by IL-1beta.	Celecoxib	30-39	interleukin 1 beta	Homo sapiens	148-156
15379214-6	2004	The COX-2 specific inhibitor, celecoxib, in contrast to the nonspecific COX inhibitor, indomethacin, markedly reduced mPGES-1 expression induced by IL-1beta.	Indomethacin	87-99	interleukin 1 beta	Homo sapiens	148-156
15379214-7	2004	The results demonstrate that mPGES-1 regulates PGE2 production in gingival fibroblasts stimulated by inflammatory mediators IL-1beta and TNFa.	Dinoprostone	47-51	interleukin 1 beta	Homo sapiens	124-132
14999749-5	2004	Addition of titanium particles increased release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta).	Titanium	12-20	interleukin 1 beta	Homo sapiens	119-137
14999749-5	2004	Addition of titanium particles increased release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta).	Titanium	12-20	interleukin 1 beta	Homo sapiens	139-148
14676210-1	2004	Recently, we demonstrated that ceramide kinase, and its product, ceramide 1-phosphate (Cer-1-P), were mediators of arachidonic acid released in cells in response to interleukin-1beta and calcium ionophore (Pettus, B. J., Bielawska, A., Spiegel, S., Roddy, P., Hannun, Y.	ceramide 1-phosphate	65-85	interleukin 1 beta	Homo sapiens	165-182
15034930-6	2004	Treatment of Caco-2 cells with cycloheximide (10 microg/ml) increased IL-6 mRNA and protein levels in IL-1beta-treated cells and this was associated with increased mRNA stabilization.	Cycloheximide	31-44	interleukin 1 beta	Homo sapiens	102-110
14676210-1	2004	Recently, we demonstrated that ceramide kinase, and its product, ceramide 1-phosphate (Cer-1-P), were mediators of arachidonic acid released in cells in response to interleukin-1beta and calcium ionophore (Pettus, B. J., Bielawska, A., Spiegel, S., Roddy, P., Hannun, Y.	Arachidonic Acid	115-131	interleukin 1 beta	Homo sapiens	165-182
15004138-1	2004	Priming of monocytes with LPS produces large quantities of intracellular, biologically inactive IL-1beta that can be processed and released by subsequent activation of the P2X7 receptor by extracellular ATP.	Adenosine Triphosphate	203-206	interleukin 1 beta	Homo sapiens	96-104
15061967-10	2004	POF and DEX also inhibited the LPS-stimulated production of all cytokines except of IL-1beta and sTNFR1 (P &lt; 0.001 or P &lt; 0.01 or P &lt; 0.05).	Dexamethasone	8-11	interleukin 1 beta	Homo sapiens	84-92
15004138-4	2004	The level of ATP-induced IL-1beta released in 2 h from LPS-activated whole blood from homozygous subjects was 50% of that from wild-type samples.	Adenosine Triphosphate	13-16	interleukin 1 beta	Homo sapiens	25-33
15004138-5	2004	A more marked defect in IL-1beta release was observed from LPS-activated monocytes of homozygous subjects which was only 22% of that released from wild-type monocytes after a 30-min incubation with ATP.	Adenosine Triphosphate	198-201	interleukin 1 beta	Homo sapiens	24-32
15004138-6	2004	However, after a 60-min incubation with ATP, the amount of IL-1beta released from homozygous monocytes was 70% of that released from wild-type monocytes.	Adenosine Triphosphate	40-43	interleukin 1 beta	Homo sapiens	59-67
15004138-7	2004	Incubation of monocytes of either genotype with nigericin resulted in a similar release of IL-1beta.	Nigericin	48-57	interleukin 1 beta	Homo sapiens	91-99
15004138-8	2004	Western blotting demonstrated that ATP induced the release of mature 17-kDa IL-1beta from monocytes, and confirmed that this process was impaired in homozygous monocytes.	Adenosine Triphosphate	35-38	interleukin 1 beta	Homo sapiens	76-84
15004138-10	2004	The results indicate that ATP-induced release of IL-1beta is slower in monocytes from subjects homozygous for the Glu496Ala polymorphism in the P2X7 receptor and that this reduced rate of IL-1beta release is associated with a lower ATP-induced K+ efflux.	Adenosine Triphosphate	26-29	interleukin 1 beta	Homo sapiens	49-57
15004138-10	2004	The results indicate that ATP-induced release of IL-1beta is slower in monocytes from subjects homozygous for the Glu496Ala polymorphism in the P2X7 receptor and that this reduced rate of IL-1beta release is associated with a lower ATP-induced K+ efflux.	Adenosine Triphosphate	26-29	interleukin 1 beta	Homo sapiens	188-196
15004138-10	2004	The results indicate that ATP-induced release of IL-1beta is slower in monocytes from subjects homozygous for the Glu496Ala polymorphism in the P2X7 receptor and that this reduced rate of IL-1beta release is associated with a lower ATP-induced K+ efflux.	Adenosine Triphosphate	232-235	interleukin 1 beta	Homo sapiens	49-57
14967193-8	2004	Dex, but not Rad, inhibited IL-1beta expression.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	28-36
15036249-0	2004	Aspirin inhibits TNFalpha- and IL-1-induced NF-kappaB activation and sensitizes HeLa cells to apoptosis.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	31-35
15036249-5	2004	Our studies reveal that acetylsalicylic acid (aspirin) prevents TNFalpha- and IL-1-induced NF-kappaB activation in a dose-dependent manner through inhibition of phosphorylation and degradation of IkappaBalpha and IkappaBbeta.	Aspirin	24-44	interleukin 1 beta	Homo sapiens	78-82
15036249-5	2004	Our studies reveal that acetylsalicylic acid (aspirin) prevents TNFalpha- and IL-1-induced NF-kappaB activation in a dose-dependent manner through inhibition of phosphorylation and degradation of IkappaBalpha and IkappaBbeta.	Aspirin	46-53	interleukin 1 beta	Homo sapiens	78-82
14967193-10	2004	These results suggest that Hsp90 inhibitor itself inhibits the activation of NF-kappaB and AP-1, however, impedes Dex-induced inhibition of IL-1beta induction by attenuating Dex-mediated activation of GR and inhibition of the proinflammatory transcription factors.	Dexamethasone	114-117	interleukin 1 beta	Homo sapiens	140-148
14967193-10	2004	These results suggest that Hsp90 inhibitor itself inhibits the activation of NF-kappaB and AP-1, however, impedes Dex-induced inhibition of IL-1beta induction by attenuating Dex-mediated activation of GR and inhibition of the proinflammatory transcription factors.	Dexamethasone	174-177	interleukin 1 beta	Homo sapiens	140-148
14993105-10	2004	Diosmectite post-treatment resulted in amelioration of the morphological signs (intestinal weight, macroscopic damage, necrosed area, histology) and biochemical markers (myeloperoxidase activity, glutathione levels, MUC2 expression, inducible nitric oxide synthase and interleukin-1beta (IL-1beta) and leukotriene B(4) synthesis), as well as in the reduction of the severity of diarrhoea.	Smectite	0-11	interleukin 1 beta	Homo sapiens	288-296
15209387-11	2004	Inhibition of local production of IL-1beta could be one of the mechanisms used by MgSO4 to reduce the vasoconstrictory effect of Ag II and TX in human placental cotyledone.	Magnesium Sulfate	82-87	interleukin 1 beta	Homo sapiens	34-42
14967724-5	2004	Cilostazol (1 to 100 micromol/L) significantly suppressed not only NAD(P)H oxidase-dependent superoxide production but also TNF-alpha and interleukin-1beta release and restored viability.	Cilostazol	0-10	interleukin 1 beta	Homo sapiens	138-155
14993811-0	2004	Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor.	Polycyclic Aromatic Hydrocarbons	0-31	interleukin 1 beta	Homo sapiens	57-75
14993811-3	2004	When human fibroblast-like synoviocytes line, MH7A, was treated with 3-methylcholanthrene (3-MC), a polycyclic aromatic hydrocarbon (PAH), mRNA of IL-1beta was up-regulated.	Methylcholanthrene	69-89	interleukin 1 beta	Homo sapiens	147-155
14993811-3	2004	When human fibroblast-like synoviocytes line, MH7A, was treated with 3-methylcholanthrene (3-MC), a polycyclic aromatic hydrocarbon (PAH), mRNA of IL-1beta was up-regulated.	Methylcholanthrene	91-95	interleukin 1 beta	Homo sapiens	147-155
14993811-3	2004	When human fibroblast-like synoviocytes line, MH7A, was treated with 3-methylcholanthrene (3-MC), a polycyclic aromatic hydrocarbon (PAH), mRNA of IL-1beta was up-regulated.	Polycyclic Aromatic Hydrocarbons	100-131	interleukin 1 beta	Homo sapiens	147-155
14993105-10	2004	Diosmectite post-treatment resulted in amelioration of the morphological signs (intestinal weight, macroscopic damage, necrosed area, histology) and biochemical markers (myeloperoxidase activity, glutathione levels, MUC2 expression, inducible nitric oxide synthase and interleukin-1beta (IL-1beta) and leukotriene B(4) synthesis), as well as in the reduction of the severity of diarrhoea.	Smectite	0-11	interleukin 1 beta	Homo sapiens	269-286
14993105-15	2004	Diosmectite had a dose-dependent inhibitory effect on IL-1beta production by LPS-stimulated THP-1 cells.	Smectite	0-11	interleukin 1 beta	Homo sapiens	54-62
15086545-2	2004	When COME cells were treated with IL-1beta or EGF, early and marked increases and subsequent rapid decreases were observed for all HAS genes and, moreover, actual changes in hyaluronan synthesis subsequently occurred.	Hyaluronic Acid	174-184	interleukin 1 beta	Homo sapiens	34-42
14743348-0	2004	How adhesion, migration, and cytoplasmic calcium transients influence interleukin-1beta mRNA stabilization in human monocytes.	Calcium	41-48	interleukin 1 beta	Homo sapiens	70-87
15014040-7	2004	A NF-kappaB inhibitor, pyrrolidine dithiocarbamate, suppressed both MMP-9 expression and invasiveness of IL-1beta-treated GCTM-1 cells.	pyrrolidine dithiocarbamic acid	23-50	interleukin 1 beta	Homo sapiens	105-113
14981131-3	2004	In HGF from healthy gingiva, PGE2 down-regulated IL-1beta-induced MMP-3 production, whereas in HGF from periodontitis patients, PGE2 enhanced it.	Dinoprostone	29-33	interleukin 1 beta	Homo sapiens	49-57
14981131-4	2004	Butaprost (an EP2 agonist) and ONO-AE1-329 (an EP4 agonist) suppressed IL-1beta-induced MMP-3 production, and 17-phenyl-omega-trinor PGE2 (an EP1 agonist) mimicked the PGE(2) effect in HGF from healthy and periodontally diseased tissues, respectively.	butaprost	0-9	interleukin 1 beta	Homo sapiens	71-79
14981131-4	2004	Butaprost (an EP2 agonist) and ONO-AE1-329 (an EP4 agonist) suppressed IL-1beta-induced MMP-3 production, and 17-phenyl-omega-trinor PGE2 (an EP1 agonist) mimicked the PGE(2) effect in HGF from healthy and periodontally diseased tissues, respectively.	ONO-AE1-329	31-42	interleukin 1 beta	Homo sapiens	71-79
14981131-5	2004	Analysis of these data suggests that, in HGF from healthy tissue, IL-1beta-induced MMP-3 production is down-regulated by PGE2 via EP2 and EP4 receptors, whereas in cells from periodontally diseased tissue, IL-1beta-induced MMP-3 production is up-regulated via EP1 receptors.	Dinoprostone	121-125	interleukin 1 beta	Homo sapiens	66-74
14981131-6	2004	Different regulation of IL-1beta-induced MMP-3 production by PGE2 between healthy and periodontally diseased tissues may be involved in the pathogenesis of periodontal disease.	Dinoprostone	61-65	interleukin 1 beta	Homo sapiens	24-32
15008941-5	2004	In addition, RNA from THP-1 cells was used in Northern blots to determine whether inhibition of secretion of IL-1 beta and TNF-alpha by gemifloxacin occurred at the transcription or translation level.	Gemifloxacin	136-148	interleukin 1 beta	Homo sapiens	109-118
14657012-4	2004	However, treatment with the proinflammatory cytokines, TNFalpha and IL-1 beta, resulted in time- and dose-dependent increases in PAPP-A mRNA and protein expression (3- to 4-fold maximal effects), which were prevented by actinomycin D.	Dactinomycin	220-233	interleukin 1 beta	Homo sapiens	68-77
15086545-4	2004	When two different types of fibroblasts were treated with IL-1beta or EGF, increased expression with different degrees and rates of three different HAS genes and subsequent increased synthesis of hyaluronan were also observed.	Hyaluronic Acid	196-206	interleukin 1 beta	Homo sapiens	58-66
14634045-4	2004	KN-62 and PPADS also blocked BzATP-induced IL-1beta release (EC(50) = 617 microM) with IC(50) values of 75 and 3500 nM, respectively.	BzATP	29-34	interleukin 1 beta	Homo sapiens	43-51
14617690-7	2004	Furthermore, AGI-1067 inhibited the inducible expression of the redox-sensitive genes, vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1, in endothelial cells as well as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 production in peripheral blood mononuclear cells, whereas probucol had no effect.	succinobucol	13-21	interleukin 1 beta	Homo sapiens	243-265
14634045-7	2004	Two caspase inhibitors, YVAD (caspase 1) and DEVD (caspase 3), attenuated both BzATP-induced pore formation and IL-1beta release in a concentration-dependent fashion.	YVAD	24-28	interleukin 1 beta	Homo sapiens	112-120
14634045-7	2004	Two caspase inhibitors, YVAD (caspase 1) and DEVD (caspase 3), attenuated both BzATP-induced pore formation and IL-1beta release in a concentration-dependent fashion.	DEVD	45-49	interleukin 1 beta	Homo sapiens	112-120
14975696-5	2004	In a dose-dependent manner, ibudilast suppressed the production of nitric oxide (NO), reactive oxygen species, interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha and enhanced the production of the inhibitory cytokine, IL-10, and additional neurotrophic factors, including nerve growth factor (NGF), glia-derived neurotrophic factor (GDNF), and neurotrophin (NT)-4 in activated microglia.	ibudilast	28-37	interleukin 1 beta	Homo sapiens	111-133
15162835-4	2004	Madimadi dose-dependently inhibited TNF-alpha, IL-1beta, and IL-8 production from activated human mast cells (HMC-1).	madimadi	0-8	interleukin 1 beta	Homo sapiens	47-55
14996278-0	2004	Interleukin-1beta induces matrix metalloproteinase-1 expression in cultured human gingival fibroblasts: role of cyclooxygenase-2 and prostaglandin E2.	Dinoprostone	133-149	interleukin 1 beta	Homo sapiens	0-17
14996278-4	2004	The effect of indomethacin, dexamethasone, or cycloheximide (CHX) on the IL-1beta-induced expression of MMP-1 was examined.	Indomethacin	14-26	interleukin 1 beta	Homo sapiens	73-81
14996278-4	2004	The effect of indomethacin, dexamethasone, or cycloheximide (CHX) on the IL-1beta-induced expression of MMP-1 was examined.	Cycloheximide	46-59	interleukin 1 beta	Homo sapiens	73-81
14996278-4	2004	The effect of indomethacin, dexamethasone, or cycloheximide (CHX) on the IL-1beta-induced expression of MMP-1 was examined.	Cycloheximide	61-64	interleukin 1 beta	Homo sapiens	73-81
14996278-7	2004	Pretreatment of the cells with indomethacin or dexamethasone inhibited the IL-1beta-induced MMP-1 expression.	Indomethacin	31-43	interleukin 1 beta	Homo sapiens	75-83
14996278-7	2004	Pretreatment of the cells with indomethacin or dexamethasone inhibited the IL-1beta-induced MMP-1 expression.	Dexamethasone	47-60	interleukin 1 beta	Homo sapiens	75-83
14996278-10	2004	CONCLUSION: The IL-1beta-induced MMP-1 expression in gingival fibroblasts may be mediated, at least in part, by COX-2 and its product PGE2.	Dinoprostone	134-138	interleukin 1 beta	Homo sapiens	16-24
14670842-0	2004	Interleukin-1beta, transforming growth factor-beta1, and bradykinin attenuate cyclic AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin E2 by cyclooxygenase-2 induction and downregulation of adenylyl cyclase isoforms 1, 2, and 4.	Cyclic AMP	78-88	interleukin 1 beta	Homo sapiens	0-17
14670842-0	2004	Interleukin-1beta, transforming growth factor-beta1, and bradykinin attenuate cyclic AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin E2 by cyclooxygenase-2 induction and downregulation of adenylyl cyclase isoforms 1, 2, and 4.	Epoprostenol	161-173	interleukin 1 beta	Homo sapiens	0-17
14670842-0	2004	Interleukin-1beta, transforming growth factor-beta1, and bradykinin attenuate cyclic AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin E2 by cyclooxygenase-2 induction and downregulation of adenylyl cyclase isoforms 1, 2, and 4.	Dinoprostone	188-204	interleukin 1 beta	Homo sapiens	0-17
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Cyclic AMP	167-171	interleukin 1 beta	Homo sapiens	71-88
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Cyclic AMP	167-171	interleukin 1 beta	Homo sapiens	90-98
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Dinoprostone	273-289	interleukin 1 beta	Homo sapiens	71-88
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Dinoprostone	273-289	interleukin 1 beta	Homo sapiens	90-98
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Dinoprostone	291-295	interleukin 1 beta	Homo sapiens	71-88
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Dinoprostone	291-295	interleukin 1 beta	Homo sapiens	90-98
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Epoprostenol	305-309	interleukin 1 beta	Homo sapiens	71-88
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Epoprostenol	305-309	interleukin 1 beta	Homo sapiens	90-98
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Iloprost	320-328	interleukin 1 beta	Homo sapiens	71-88
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	Iloprost	320-328	interleukin 1 beta	Homo sapiens	90-98
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	carboprostacyclin	333-350	interleukin 1 beta	Homo sapiens	71-88
14670842-3	2004	In this study, we show that prolonged incubation with bradykinin (BK), interleukin-1beta (IL-1beta), and transforming growth factor-beta1 (TGF-beta1) markedly impairs cAMP accumulation in human pulmonary artery smooth muscle cells in response to short-term incubation with prostaglandin E2 (PGE2) and the PGI2 analogues iloprost and carbaprostacyclin.	carboprostacyclin	333-350	interleukin 1 beta	Homo sapiens	90-98
14670842-6	2004	The effect of IL-1beta, BK, and TGF-beta1 on cAMP levels was abrogated by the selective COX-2 inhibitor NS398.	Cyclic AMP	45-49	interleukin 1 beta	Homo sapiens	14-22
14670842-6	2004	The effect of IL-1beta, BK, and TGF-beta1 on cAMP levels was abrogated by the selective COX-2 inhibitor NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	104-109	interleukin 1 beta	Homo sapiens	14-22
14670842-8	2004	Consistent with this, IL-1beta, BK, and TGF-beta1 all induced COX-2 and PGE2 release.	Dinoprostone	72-76	interleukin 1 beta	Homo sapiens	22-30
14670842-9	2004	These results show that BK, IL-1beta, and TGF-beta1 downregulate adenylyl cyclase in human pulmonary artery smooth muscle cells via COX-2 induction and prostanoid release.	Prostaglandins	152-162	interleukin 1 beta	Homo sapiens	28-36
14973050-6	2004	This stimulated IL-1beta secretion could be attributed to nitric oxide (NO) released by the fibroblasts as an IL-1beta-inducing factor.	Nitric Oxide	58-70	interleukin 1 beta	Homo sapiens	16-24
14973050-6	2004	This stimulated IL-1beta secretion could be attributed to nitric oxide (NO) released by the fibroblasts as an IL-1beta-inducing factor.	Nitric Oxide	58-70	interleukin 1 beta	Homo sapiens	110-118
14973050-8	2004	Incubation of T3M4 and PT45-P1 cells with the NO donor S-Nitroso-N-acetyl-D,L-penicillamine up-regulated IL-1beta secretion and conferred resistance toward etoposide-induced apoptosis.	snap	55-91	interleukin 1 beta	Homo sapiens	105-113
15162835-6	2004	In addition, we confirmed potent inhibition of TNF-alpha and IL-1beta production by Madimadi using purified human blood PBMC from an active RA group, but not from healthy or disease control groups.	madimadi	84-92	interleukin 1 beta	Homo sapiens	61-69
14757123-3	2004	Recombinant human interleukin-1 beta increased prostaglandin E(2) synthesis in fibroblasts about sixfold.	Dinoprostone	47-65	interleukin 1 beta	Homo sapiens	18-36
14960322-2	2004	Complete inhibition of interleukin (IL)-1beta-induced Akt phosphorylation occurred at 50 microM LY29 or 100 nM WM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-100	interleukin 1 beta	Homo sapiens	23-45
14757123-8	2004	The effects of vasopressin on basal and interleukin-1 beta-induced prostaglandin E(2) synthesis were antagonized by selective vasopressin receptor antagonists.	Dinoprostone	67-85	interleukin 1 beta	Homo sapiens	40-58
14757123-4	2004	The prostaglandin E(2) response to interleukin-1 beta was attenuated by lower concentrations of vasopressin (10(-10)-10(-9) M).	Dinoprostone	4-22	interleukin 1 beta	Homo sapiens	35-53
14757123-5	2004	By contrast, higher concentrations (10(-8)-10(-7) M) of vasopressin effected significant enhancement of the interleukin-1 beta-induced prostaglandin E(2) synthesis.	Dinoprostone	135-153	interleukin 1 beta	Homo sapiens	108-126
14974940-6	2004	Sodium salicylate administration reduced IL-1beta and IFN-gamma mRNA in both small-for-size and whole allografts, but it could decrease IL-2 and IL-10 mRNA levels only in small-for-size allografts.	Sodium Salicylate	0-17	interleukin 1 beta	Homo sapiens	41-49
14974940-7	2004	In vitro study revealed that CD80, CD86 and CD11b expression on macrophages was augmented after IL-1beta stimulation, whereas the up-regulation could be blocked by sodium salicylate.	Sodium Salicylate	164-181	interleukin 1 beta	Homo sapiens	96-104
14872494-0	2004	Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage.	Hyaluronic Acid	86-96	interleukin 1 beta	Homo sapiens	14-31
14989392-10	2004	Pentoxifylline and dexamethasone also inhibited the LPS-stimulated production of all cytokines except IL-1beta and sTNFR1.	Pentoxifylline	0-14	interleukin 1 beta	Homo sapiens	102-110
14989392-10	2004	Pentoxifylline and dexamethasone also inhibited the LPS-stimulated production of all cytokines except IL-1beta and sTNFR1.	Dexamethasone	19-32	interleukin 1 beta	Homo sapiens	102-110
14725856-1	2004	TCDD stimulated IL-1beta gene expression in differentiating human keratinocyte cell lines in a time- and dose-dependent manner.	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Homo sapiens	16-24
14725856-2	2004	Increases in prointerleukin-1beta (pIL-1beta) protein and IL-1beta steady state mRNA levels were observed in both SCC-12F and HaCaT cells following TCDD treatment.	Polychlorinated Dibenzodioxins	148-152	interleukin 1 beta	Homo sapiens	13-33
14872494-1	2004	OBJECTIVE: To investigate the mechanism of the inhibitory action of hyaluronan (HA) on interleukin-1beta (IL-1beta)-stimulated production of matrix metalloproteinases (MMPs) in human articular cartilage.	Hyaluronic Acid	68-78	interleukin 1 beta	Homo sapiens	87-104
14725856-2	2004	Increases in prointerleukin-1beta (pIL-1beta) protein and IL-1beta steady state mRNA levels were observed in both SCC-12F and HaCaT cells following TCDD treatment.	Polychlorinated Dibenzodioxins	148-152	interleukin 1 beta	Homo sapiens	36-44
14872494-1	2004	OBJECTIVE: To investigate the mechanism of the inhibitory action of hyaluronan (HA) on interleukin-1beta (IL-1beta)-stimulated production of matrix metalloproteinases (MMPs) in human articular cartilage.	Hyaluronic Acid	68-78	interleukin 1 beta	Homo sapiens	106-114
14725856-3	2004	When pretreated with alpha-naphthoflavone, an AhR antagonist, TCDD-mediated increases in IL-1beta gene expression were attenuated, demonstrating for the first time that the environmental toxin, TCDD, can stimulate cytokine (IL-1beta) gene expression in an AhR-dependent manner.	alpha-naphthoflavone	21-41	interleukin 1 beta	Homo sapiens	89-97
15016032-2	2004	MATERIAL AND METHODS: Human embryo palatal mesenchyme (HEPM) cells were used for testing the inhibition of IL-1beta-stimulated PGE2-production in vitro by different concentrations of oxybenzone.	Dinoprostone	127-131	interleukin 1 beta	Homo sapiens	107-115
14725856-3	2004	When pretreated with alpha-naphthoflavone, an AhR antagonist, TCDD-mediated increases in IL-1beta gene expression were attenuated, demonstrating for the first time that the environmental toxin, TCDD, can stimulate cytokine (IL-1beta) gene expression in an AhR-dependent manner.	alpha-naphthoflavone	21-41	interleukin 1 beta	Homo sapiens	224-232
14725856-3	2004	When pretreated with alpha-naphthoflavone, an AhR antagonist, TCDD-mediated increases in IL-1beta gene expression were attenuated, demonstrating for the first time that the environmental toxin, TCDD, can stimulate cytokine (IL-1beta) gene expression in an AhR-dependent manner.	Polychlorinated Dibenzodioxins	62-66	interleukin 1 beta	Homo sapiens	89-97
14725856-3	2004	When pretreated with alpha-naphthoflavone, an AhR antagonist, TCDD-mediated increases in IL-1beta gene expression were attenuated, demonstrating for the first time that the environmental toxin, TCDD, can stimulate cytokine (IL-1beta) gene expression in an AhR-dependent manner.	Polychlorinated Dibenzodioxins	62-66	interleukin 1 beta	Homo sapiens	224-232
14725856-3	2004	When pretreated with alpha-naphthoflavone, an AhR antagonist, TCDD-mediated increases in IL-1beta gene expression were attenuated, demonstrating for the first time that the environmental toxin, TCDD, can stimulate cytokine (IL-1beta) gene expression in an AhR-dependent manner.	Polychlorinated Dibenzodioxins	194-198	interleukin 1 beta	Homo sapiens	89-97
14725856-3	2004	When pretreated with alpha-naphthoflavone, an AhR antagonist, TCDD-mediated increases in IL-1beta gene expression were attenuated, demonstrating for the first time that the environmental toxin, TCDD, can stimulate cytokine (IL-1beta) gene expression in an AhR-dependent manner.	Polychlorinated Dibenzodioxins	194-198	interleukin 1 beta	Homo sapiens	224-232
14725856-5	2004	Results showed high constitutive levels of IL-1beta transcriptional activity, however, TCDD treatment, which stimulated IL-1beta steady state mRNA levels, failed to potentiate IL-1beta transcription.	Polychlorinated Dibenzodioxins	87-91	interleukin 1 beta	Homo sapiens	120-128
14725856-5	2004	Results showed high constitutive levels of IL-1beta transcriptional activity, however, TCDD treatment, which stimulated IL-1beta steady state mRNA levels, failed to potentiate IL-1beta transcription.	Polychlorinated Dibenzodioxins	87-91	interleukin 1 beta	Homo sapiens	120-128
14734742-9	2004	Furthermore, MEKK2 immunoprecipitates activated c-Jun in an IL-1 dependent manner and this activity was inhibited by the selective JNK inhibitor SP600125.	pyrazolanthrone	145-153	interleukin 1 beta	Homo sapiens	60-64
14748720-8	2004	IL-1beta inhibited [(3)H]cholesterol efflux from HMCs by inhibition of the peroxisome-proliferator-activated receptor/LXR (liver X receptor)/ABCA1 pathway.	Cholesterol	25-36	interleukin 1 beta	Homo sapiens	0-8
14749287-7	2004	Given that hyperglycemia has been reported to increase human beta-cell production of interleukin-1beta and that this cytokine can induce COX-2 expression, our observations of glucose-induced induction of COX-2 in human islets suggest that this is one route through which hyperglycemia may contribute to beta-cell dysfunction.	Glucose	175-182	interleukin 1 beta	Homo sapiens	85-102
15016032-2	2004	MATERIAL AND METHODS: Human embryo palatal mesenchyme (HEPM) cells were used for testing the inhibition of IL-1beta-stimulated PGE2-production in vitro by different concentrations of oxybenzone.	oxybenzone	183-193	interleukin 1 beta	Homo sapiens	107-115
14741428-2	2004	Thirty minutes of exposure to the selective P2X7 agonist 2"-3"-O-(4-benzoylbenzoyl)adenosine 5"-triphosphate (BzATP) resulted in the secretion of IL-1beta after either Abeta(1-42) or LPS stimulation of human macrophages that was dependent on the concentration of the stimulus used to pre-activate the cells.	2"-3"-o-(4-benzoylbenzoyl)adenosine 5"-triphosphate	57-108	interleukin 1 beta	Homo sapiens	146-154
14634065-3	2004	Although these are detectable even without stimulation, immunoglobulin (Ig)E receptor cross-linking is able to enhance only TNF-alpha production, but phorbol 12-myristate 13-acetate additionally promotes IL-1beta and IL-8.	Tetradecanoylphorbol Acetate	150-181	interleukin 1 beta	Homo sapiens	204-212
14741428-2	2004	Thirty minutes of exposure to the selective P2X7 agonist 2"-3"-O-(4-benzoylbenzoyl)adenosine 5"-triphosphate (BzATP) resulted in the secretion of IL-1beta after either Abeta(1-42) or LPS stimulation of human macrophages that was dependent on the concentration of the stimulus used to pre-activate the cells.	BzATP	110-115	interleukin 1 beta	Homo sapiens	146-154
14741428-3	2004	Further tests on human microglia treated with BzATP (300 microM) resulted in a 1.5- and 3.5-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 10 microM Abeta(1-42) and a 1.6- and 3.9-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 1 microg/ml LPS.	BzATP	46-51	interleukin 1 beta	Homo sapiens	126-134
14741428-3	2004	Further tests on human microglia treated with BzATP (300 microM) resulted in a 1.5- and 3.5-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 10 microM Abeta(1-42) and a 1.6- and 3.9-fold enhancement of IL-1alpha and IL-1beta secretion, respectively, from cells pre-activated by 1 microg/ml LPS.	BzATP	46-51	interleukin 1 beta	Homo sapiens	263-271
14741428-4	2004	BzATP induction of IL-1alpha and IL-1beta secretion from microglia was completely reversed by pre-incubation of the cells with the P2X7 antagonist, adenosine 5"-triphosphate 2",3"-acyclic dialcohol (oxidized ATP).	BzATP	0-5	interleukin 1 beta	Homo sapiens	33-41
14966463-7	2004	The response to IL-1beta was consistent in the total cell and nuclear extracts and was significantly reduced by pretreatment with actinomycin D or cycloheximide.	Dactinomycin	130-143	interleukin 1 beta	Homo sapiens	16-24
14966463-7	2004	The response to IL-1beta was consistent in the total cell and nuclear extracts and was significantly reduced by pretreatment with actinomycin D or cycloheximide.	Cycloheximide	147-160	interleukin 1 beta	Homo sapiens	16-24
14741428-4	2004	BzATP induction of IL-1alpha and IL-1beta secretion from microglia was completely reversed by pre-incubation of the cells with the P2X7 antagonist, adenosine 5"-triphosphate 2",3"-acyclic dialcohol (oxidized ATP).	adenosine 5"-triphosphate 2",3"-acyclic dialcohol	148-197	interleukin 1 beta	Homo sapiens	33-41
14741428-4	2004	BzATP induction of IL-1alpha and IL-1beta secretion from microglia was completely reversed by pre-incubation of the cells with the P2X7 antagonist, adenosine 5"-triphosphate 2",3"-acyclic dialcohol (oxidized ATP).	Adenosine Triphosphate	2-5	interleukin 1 beta	Homo sapiens	33-41
14998300-0	2004	15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells.	15-deoxy-delta(12,14)-prostaglandin J2	0-38	interleukin 1 beta	Homo sapiens	52-60
14600251-0	2004	Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes.	polyphenol epigallocatechin-3-gallate	10-47	interleukin 1 beta	Homo sapiens	79-97
14600251-0	2004	Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes.	epigallocatechin gallate	49-53	interleukin 1 beta	Homo sapiens	79-97
14600251-3	2004	Here we show that EGCG at micromolar concentrations was highly effective in inhibiting the IL-1beta-induced glycosaminoglycan (GAG) release from human cartilage explants in vitro.	epigallocatechin gallate	18-22	interleukin 1 beta	Homo sapiens	91-99
14600251-4	2004	EGCG also inhibited the IL-1beta-induced mRNA and protein expression of MMP-1 and MMP-13 in human chondrocytes.	epigallocatechin gallate	0-4	interleukin 1 beta	Homo sapiens	24-32
14600251-8	2004	These results also suggest that EGCG or compounds derived from it may be therapeutically effective inhibitors of IL-1beta-induced production of matrix-degrading enzymes in arthritis.	epigallocatechin gallate	32-36	interleukin 1 beta	Homo sapiens	113-121
15068113-8	2004	Endogenous PGE2 partially mediated the IL-1beta-induced RANKL mRNA expression.	Dinoprostone	11-15	interleukin 1 beta	Homo sapiens	39-47
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Aspirin	101-108	interleukin 1 beta	Homo sapiens	178-182
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Sodium Salicylate	119-136	interleukin 1 beta	Homo sapiens	90-94
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Sodium Salicylate	119-136	interleukin 1 beta	Homo sapiens	178-182
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Mesalamine	222-243	interleukin 1 beta	Homo sapiens	90-94
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Mesalamine	245-250	interleukin 1 beta	Homo sapiens	90-94
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Mesalamine	245-250	interleukin 1 beta	Homo sapiens	178-182
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Indomethacin	255-267	interleukin 1 beta	Homo sapiens	90-94
14742690-3	2004	This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise enhanced IL-1-mediated COX-2 gene expression whereas 5-aminosalicylic acid (5-ASA) or indomethacin had no effect.	Indomethacin	255-267	interleukin 1 beta	Homo sapiens	178-182
14742690-6	2004	The COX-2 mRNA half-life in IL-1 treated cells was 1 h and was increased in excess of 5 h in IL-1 + aspirin-treated cells.	Aspirin	100-107	interleukin 1 beta	Homo sapiens	28-32
14742690-6	2004	The COX-2 mRNA half-life in IL-1 treated cells was 1 h and was increased in excess of 5 h in IL-1 + aspirin-treated cells.	Aspirin	100-107	interleukin 1 beta	Homo sapiens	93-97
14742690-11	2004	Aspirin also enhanced steady-state mRNA levels of other IL-1 modulated genes (IL-1beta, IL-6, groalpha, and TNFalpha) that are likewise regulated at the level of message stability via p38 activation.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	56-60
14742690-11	2004	Aspirin also enhanced steady-state mRNA levels of other IL-1 modulated genes (IL-1beta, IL-6, groalpha, and TNFalpha) that are likewise regulated at the level of message stability via p38 activation.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	78-86
14998300-6	2004	When the cells were pretreated with 15d-PGJ2 for 1 hour, the IL-1beta-induced GM-CSF expression was inhibited in a concentration-dependent manner (2-50 microM).	15-deoxy-delta(12,14)-prostaglandin J2	36-44	interleukin 1 beta	Homo sapiens	61-69
14693163-4	2004	Glucan induced the highest level of IL-1beta mRNA and protein release after 3 h. IL-8 was induced at 3 h after glucan, but not after LPS, induction, which indicates different induction pathways.	Glucans	0-6	interleukin 1 beta	Homo sapiens	36-44
15225371-12	2004	In comparison with 6-keto-PGF1alpha and thromboxane B2, the production of PGE2 was greater after chondrocytes were stimulated by IL-1beta or TNF-alpha.	Dinoprostone	74-78	interleukin 1 beta	Homo sapiens	129-137
14729123-2	2004	Preincubation with nitroparacetamol or nitroflurbiprofen (but not paracetamol or flurbiprofen) caused dose-related inhibition of the formation of interleukin 1 beta (IC(50)s, 44.5 and 362 microM, n=12) and tumour necrosis factor-alpha (IC(50)s, 9.0 and 0.0009 microM, n=12).	4-(nitroxy)butanoic acid 4-acetylaminophenyl ester	19-35	interleukin 1 beta	Homo sapiens	146-164
14729123-2	2004	Preincubation with nitroparacetamol or nitroflurbiprofen (but not paracetamol or flurbiprofen) caused dose-related inhibition of the formation of interleukin 1 beta (IC(50)s, 44.5 and 362 microM, n=12) and tumour necrosis factor-alpha (IC(50)s, 9.0 and 0.0009 microM, n=12).	nitroflurbiprofen	39-56	interleukin 1 beta	Homo sapiens	146-164
14729123-2	2004	Preincubation with nitroparacetamol or nitroflurbiprofen (but not paracetamol or flurbiprofen) caused dose-related inhibition of the formation of interleukin 1 beta (IC(50)s, 44.5 and 362 microM, n=12) and tumour necrosis factor-alpha (IC(50)s, 9.0 and 0.0009 microM, n=12).	Acetaminophen	24-35	interleukin 1 beta	Homo sapiens	146-164
14729123-2	2004	Preincubation with nitroparacetamol or nitroflurbiprofen (but not paracetamol or flurbiprofen) caused dose-related inhibition of the formation of interleukin 1 beta (IC(50)s, 44.5 and 362 microM, n=12) and tumour necrosis factor-alpha (IC(50)s, 9.0 and 0.0009 microM, n=12).	Flurbiprofen	44-56	interleukin 1 beta	Homo sapiens	146-164
15225371-13	2004	Conversion of PGH2 to PGE2 (PGES activity) was significantly increased in the lysate from IL-1beta-stimulated chondrocytes and it was inhibited by MK-886, which has an inhibitory effect on mPGES-1 activity.	Prostaglandin H2	14-18	interleukin 1 beta	Homo sapiens	90-98
15225371-13	2004	Conversion of PGH2 to PGE2 (PGES activity) was significantly increased in the lysate from IL-1beta-stimulated chondrocytes and it was inhibited by MK-886, which has an inhibitory effect on mPGES-1 activity.	Dinoprostone	22-26	interleukin 1 beta	Homo sapiens	90-98
14684360-8	2004	The in vitro study showed that carvedilol and R(+)-carvedilol suppressed IL-1beta production in LPS-stimulated U937 cells and that carvedilol and R(+)-carvedilol, but not metoprolol or propranolol, suppressed thiobarbituric acid-reactive substance products in myocardial membrane challenged by oxidative stress.	Carvedilol	31-41	interleukin 1 beta	Homo sapiens	73-81
14684360-8	2004	The in vitro study showed that carvedilol and R(+)-carvedilol suppressed IL-1beta production in LPS-stimulated U937 cells and that carvedilol and R(+)-carvedilol, but not metoprolol or propranolol, suppressed thiobarbituric acid-reactive substance products in myocardial membrane challenged by oxidative stress.	Carvedilol	46-61	interleukin 1 beta	Homo sapiens	73-81
14684360-8	2004	The in vitro study showed that carvedilol and R(+)-carvedilol suppressed IL-1beta production in LPS-stimulated U937 cells and that carvedilol and R(+)-carvedilol, but not metoprolol or propranolol, suppressed thiobarbituric acid-reactive substance products in myocardial membrane challenged by oxidative stress.	Carvedilol	51-61	interleukin 1 beta	Homo sapiens	73-81
15142263-11	2004	Indomethacin increased IL-1beta-induced IL-1Ra secretion in synovial fibroblasts and de-differentiated chondrocytes, suggesting that inhibition of COX-2 may indeed enhance IL-1beta-induced IL-1Ra production.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	23-31
15142263-11	2004	Indomethacin increased IL-1beta-induced IL-1Ra secretion in synovial fibroblasts and de-differentiated chondrocytes, suggesting that inhibition of COX-2 may indeed enhance IL-1beta-induced IL-1Ra production.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	172-180
15225371-13	2004	Conversion of PGH2 to PGE2 (PGES activity) was significantly increased in the lysate from IL-1beta-stimulated chondrocytes and it was inhibited by MK-886, which has an inhibitory effect on mPGES-1 activity.	MK-886	147-153	interleukin 1 beta	Homo sapiens	90-98
15225373-2	2004	Celecoxib, a selective COX-2 inhibitor, provoked a large decrease in diosgenin-induced apoptosis even in the presence of exogenous prostaglandin E2, whereas interleukin-1beta, a COX-2 inducer, strongly increased diosgenin-induced apoptosis of these synoviocytes.	Diosgenin	212-221	interleukin 1 beta	Homo sapiens	157-174
14678201-6	2004	Over-expression of the IkappaBalpha-serine mutant also inhibited reporter gene expression in response to IL-4, TNF-alpha, IL-1beta, and in some cases IFN-gamma using constructs with sequences from the pIgR promoter.	Serine	36-42	interleukin 1 beta	Homo sapiens	122-130
15470276-7	2004	Mononuclear cell adhesion to HAART-exposed HAECs was significantly enhanced following acute (24-h) exposure to the inflammatory cytokines, tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta and was suppressed by the antioxidants N-ace-tylcysteine and glutathione.	Acetylcysteine	238-255	interleukin 1 beta	Homo sapiens	176-198
15470276-7	2004	Mononuclear cell adhesion to HAART-exposed HAECs was significantly enhanced following acute (24-h) exposure to the inflammatory cytokines, tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta and was suppressed by the antioxidants N-ace-tylcysteine and glutathione.	Glutathione	260-271	interleukin 1 beta	Homo sapiens	176-198
15531779-4	2004	Through screening expression patterns of typical genes involved in atherosclerosis and foam cell generation, we could demonstrate that mRNA levels of cyclooxygenase-2, interleukin 1beta, and tumor necrosis factor-alpha were increased in a time- and dose-dependent manner in U937 macrophages treated with TCDD, like oxLDL, and that these changes accompanied significantly elevated levels of matrix-degrading metalloproteinases (MMP)-1, MMP-3, MMP-12, and MMP-13.	Polychlorinated Dibenzodioxins	304-308	interleukin 1 beta	Homo sapiens	168-185
15005008-4	2004	The aim of the present study was to evaluate the single and combined effects of physiological concentrations of cortisol, 17 beta-estradiol and IL-11 upon basal and IL-1 beta-inducible production of IL-8 in two human osteoblast-like cell lines, Saos-2 and MG-63.	Hydrocortisone	112-120	interleukin 1 beta	Homo sapiens	165-174
15005008-4	2004	The aim of the present study was to evaluate the single and combined effects of physiological concentrations of cortisol, 17 beta-estradiol and IL-11 upon basal and IL-1 beta-inducible production of IL-8 in two human osteoblast-like cell lines, Saos-2 and MG-63.	Estradiol	122-139	interleukin 1 beta	Homo sapiens	165-174
15539803-6	2004	Human beta-cells produce interleukin (IL)-1beta in response to high glucose concentrations, independently of an immune-mediated process.	Glucose	68-75	interleukin 1 beta	Homo sapiens	25-47
15096659-6	2004	Pioglitazone inhibited the expression of VCAM-1 protein and mRNA on activated human umbilical vein endothelial cells (HUVEC) after IL-1beta stimulation, as detected by ELISA and real-time PCR.	Pioglitazone	0-12	interleukin 1 beta	Homo sapiens	131-139
15630177-3	2004	Surprisingly, zerumbone markedly induced the expression of interleukin (IL)-1alpha, IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in each cell line in concentration- and time-dependent manners.	zerumbone	14-23	interleukin 1 beta	Homo sapiens	84-92
15133965-5	2004	Commercial polymer-coated Optarray slides exhibited better performance over Codelink slides in terms of activity of anti-human TNF alpha and IL-1 beta.	Polymers	11-18	interleukin 1 beta	Homo sapiens	141-150
14662725-9	2004	Budesonide potentiated the IL-1beta-enhanced expression of SCF mRNA (+103%) and protein (+98%) very shortly after treatment (at 30 min and 1 h, respectively).	Budesonide	0-10	interleukin 1 beta	Homo sapiens	27-35
15005008-8	2004	With regard to IL-1 beta-inducible production, cortisol dose-dependently inhibited IL-8 release in both cell lines (P &lt; 0.01); 17 beta-estradiol resulted in only a non-significant decrease in Saos-2, but not in MG-63 cells.	Hydrocortisone	47-55	interleukin 1 beta	Homo sapiens	15-24
15017629-3	2004	The aim of this study was to investigate whether IL-1beta polymorphism is associated with eradication rates of H. pylori by triple therapy with a proton pump inhibitor (PPI), amoxicillin, and clarithromycin.	Amoxicillin	175-186	interleukin 1 beta	Homo sapiens	49-57
15017629-3	2004	The aim of this study was to investigate whether IL-1beta polymorphism is associated with eradication rates of H. pylori by triple therapy with a proton pump inhibitor (PPI), amoxicillin, and clarithromycin.	Clarithromycin	192-206	interleukin 1 beta	Homo sapiens	49-57
15017629-8	2004	CONCLUSIONS: IL-1beta-511 polymorphism is one of the determinants of successful eradication of H. pylori using triple therapy with a PPI, amoxicillin, and clarithromycin, together with CYP2C19 genotype and bacterial resistance to clarithromycin.	Amoxicillin	138-149	interleukin 1 beta	Homo sapiens	13-21
15017629-8	2004	CONCLUSIONS: IL-1beta-511 polymorphism is one of the determinants of successful eradication of H. pylori using triple therapy with a PPI, amoxicillin, and clarithromycin, together with CYP2C19 genotype and bacterial resistance to clarithromycin.	Clarithromycin	155-169	interleukin 1 beta	Homo sapiens	13-21
15017629-8	2004	CONCLUSIONS: IL-1beta-511 polymorphism is one of the determinants of successful eradication of H. pylori using triple therapy with a PPI, amoxicillin, and clarithromycin, together with CYP2C19 genotype and bacterial resistance to clarithromycin.	Clarithromycin	230-244	interleukin 1 beta	Homo sapiens	13-21
15175940-8	2004	RESULTS: When cases were divided according to the histologic type of the tumor, a significant difference in genotype frequencies for IL-1B-1473 was observed only between intestinal-type cases and controls (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.0-3.5 and OR 2.1 and 95% CI, 1.1-4.2 in the CG and GG genotypes, respectively).	cysteinylglycine	304-306	interleukin 1 beta	Homo sapiens	133-138
15490268-0	2004	Alendronate reduces serum TNFalpha and IL-1beta, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis.	Alendronate	0-11	interleukin 1 beta	Homo sapiens	39-47
15490268-9	2004	All these findings indicate that alendronate is effective in treating CIN-associated osteopenia/osteoporosis, and that the beneficial effect of the compound may lie, at least in part, in its property to inhibit the production of TNFalpha and IL-1beta by cells of the monocyte/macrophage system, in which osteoclasts are included.	Alendronate	33-44	interleukin 1 beta	Homo sapiens	242-250
14657615-2	2004	Interleukin-1beta (IL-1beta) is known to induce NO generation, however it is not well established if IL-1beta or NO regulate production of ROS, such as superoxide anion.	Reactive Oxygen Species	139-142	interleukin 1 beta	Homo sapiens	0-17
14964492-0	2004	Effect of the carbon dioxide laser on the clinical parameters and crevicular IL-1beta when used as an adjunct to gingival flap surgery.	Carbon Dioxide	14-28	interleukin 1 beta	Homo sapiens	77-85
14964492-1	2004	OBJECTIVE: This study evaluated the effect of a carbon dioxide (CO2) laser treatment on the clinical parameters and crevicular Interleukin-1 (IL-1beta) levels when used in combination with gingival flap surgery.	Carbon Dioxide	48-62	interleukin 1 beta	Homo sapiens	142-150
14964492-9	2004	CONCLUSION: The additional use of a carbon dioxide laser on the root surface during gingival flap surgery may enhance the clinical attachment and reduce the crevicular IL-1beta concentration.	Carbon Dioxide	36-50	interleukin 1 beta	Homo sapiens	168-176
15485092-5	2004	Thus, available steroid prehormones are rapidly converted to proinflammatory estrogens in the synovial tissue in the presence of inflammatory cytokines (i.e., TNFalpha, IL-1, IL-6).	Steroids	16-23	interleukin 1 beta	Homo sapiens	169-173
14657615-2	2004	Interleukin-1beta (IL-1beta) is known to induce NO generation, however it is not well established if IL-1beta or NO regulate production of ROS, such as superoxide anion.	Reactive Oxygen Species	139-142	interleukin 1 beta	Homo sapiens	101-109
14657615-3	2004	Therefore, the main objective of this study was to evaluate the effect of IL-1beta or NO on enzyme activity of NADPH oxidase (NOX), a superoxide-generating system recently documented to participate in a variety of vascular functions.	Superoxides	134-144	interleukin 1 beta	Homo sapiens	74-82
14657615-5	2004	Nitrites accumulated in supernatants of SMC cultures were measured as an index of NO released following treatment with IL-1beta.	Nitrites	0-8	interleukin 1 beta	Homo sapiens	119-127
14664905-3	2003	Western blot analysis of IkappaBalpha protein in the cytoplasm of IL-1beta-stimulated T98G cells and electrophoretic mobility shift assay (EMSA) on corresponding nuclear extracts indicate that acetaminophen (10-1000 microM) dose-dependently inhibits both IkappaBalpha degradation and NF-kappaB nuclear translocation.	Acetaminophen	193-206	interleukin 1 beta	Homo sapiens	66-74
14603263-6	2004	Isoproterenol produced no significant change in PTX3 expression; DEX produced a significant increase at 4 and 24 h; IL-1beta induced an increase in both the groups that peaked at 4 h, declining to near basal levels at 24 h. There were no differences between melancholics or controls in mean change or maximum response with either DEX or IL-1beta.	Dexamethasone	330-333	interleukin 1 beta	Homo sapiens	116-124
15477123-4	2004	RESULTS: Therapeutic concentrations of 1,8-cineol (1.5 microg/ml=10(-5)M) inhibited significantly (n=13-19, p=0.0001) cytokine production in lymphocytes of TNF-alpha &gt; IL-1beta&gt; IL-4&gt; IL-5 by 92, 84, 70, and 65%, respectively.	Eucalyptol	39-49	interleukin 1 beta	Homo sapiens	171-179
15477123-6	2004	In the presence of 1,8-cineol (0.15 microg/ml=10(-6)M) production of TNF-alpha&gt;IL-1beta by monocytes and of IL-1beta&gt; TNF-alpha by lymph-ocytes was significantly inhibited by 77, 61 and by 36, 16%, respectively.	Eucalyptol	19-29	interleukin 1 beta	Homo sapiens	82-90
15477123-6	2004	In the presence of 1,8-cineol (0.15 microg/ml=10(-6)M) production of TNF-alpha&gt;IL-1beta by monocytes and of IL-1beta&gt; TNF-alpha by lymph-ocytes was significantly inhibited by 77, 61 and by 36, 16%, respectively.	Eucalyptol	19-29	interleukin 1 beta	Homo sapiens	111-119
15477123-7	2004	1,8-cineol (10(-6)M) had a larger impact on TNF-alpha and IL-1beta-production in monocytes compared to lymphocytes (p&lt;0.03) and similar effects (p&gt;0.59) at therapeutically relevant concentrations of 1,8-Cineol (10(-5)M).	Eucalyptol	0-10	interleukin 1 beta	Homo sapiens	58-66
15477123-8	2004	CONCLUSION: These results characterize 1,8-cineol as strong inhibitor of TNF-alpha and IL-1beta and suggest smaller effects on chemotactic cytokines.	Eucalyptol	39-49	interleukin 1 beta	Homo sapiens	87-95
14989826-0	2004	[Hydrogen peroxide upregulates interleukin-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells].	Hydrogen Peroxide	1-18	interleukin 1 beta	Homo sapiens	31-48
14989826-1	2004	OBJECTIVE: To investigate the effect of hydrogen peroxide (H(2)O(2)) on interleukin-1beta (IL-1beta)-induced cyclooxygenase-2 (COX-2) expression in human pulmonary epithelial cells (HPEC).	Hydrogen Peroxide	40-57	interleukin 1 beta	Homo sapiens	72-89
14989826-1	2004	OBJECTIVE: To investigate the effect of hydrogen peroxide (H(2)O(2)) on interleukin-1beta (IL-1beta)-induced cyclooxygenase-2 (COX-2) expression in human pulmonary epithelial cells (HPEC).	Hydrogen Peroxide	40-57	interleukin 1 beta	Homo sapiens	91-99
14989826-5	2004	(2) The concentration of PGE(2) released by HPEC treated with 5 and 10 mg/L of IL-1beta [(20.86 +/- 5.23) x 10(-6) g/L, (31.16 +/- 2.64) x 10(-6) g/L, respectively] was significantly higher than that in the control group (10.49 +/- 0.36) x 10(-6) g/L (P &lt; 0.05, respectively).	Prostaglandins E	25-28	interleukin 1 beta	Homo sapiens	79-87
14989826-7	2004	(4) The concentration of PGE(2) released by HPEC treated with 0.10, 0.25 and 0.50 mmol/L of H(2)O(2) in the presence of IL-1beta [(27.01 +/- 5.16) x 10(-6) g/L, (32.79 +/- 3.01) x 10(-6) g/L, (41.13 +/- 3.41) x 10(-6) g/L, respectively] was significantly higher than that in the control group (10.49 +/- 0.36) x 10(-6) g/L (P &lt; 0.05, respectively).	Prostaglandins E	25-28	interleukin 1 beta	Homo sapiens	120-128
14989826-7	2004	(4) The concentration of PGE(2) released by HPEC treated with 0.10, 0.25 and 0.50 mmol/L of H(2)O(2) in the presence of IL-1beta [(27.01 +/- 5.16) x 10(-6) g/L, (32.79 +/- 3.01) x 10(-6) g/L, (41.13 +/- 3.41) x 10(-6) g/L, respectively] was significantly higher than that in the control group (10.49 +/- 0.36) x 10(-6) g/L (P &lt; 0.05, respectively).	Water	92-98	interleukin 1 beta	Homo sapiens	120-128
14989826-8	2004	The concentration of PGE(2) released by cells treated with 0.25 or 0.50 mmol/L of H(2)O(2) in the presence of IL-1beta was significantly higher than that in the cells treated with IL-1beta alone (20.86 +/- 5.23) x 10(-6) g/L (P &lt; 0.05, respectively).	Prostaglandins E	21-24	interleukin 1 beta	Homo sapiens	110-118
14989826-8	2004	The concentration of PGE(2) released by cells treated with 0.25 or 0.50 mmol/L of H(2)O(2) in the presence of IL-1beta was significantly higher than that in the cells treated with IL-1beta alone (20.86 +/- 5.23) x 10(-6) g/L (P &lt; 0.05, respectively).	Prostaglandins E	21-24	interleukin 1 beta	Homo sapiens	180-188
14989826-9	2004	CONCLUSION: Hydrogen peroxide upregulates IL-1beta-induced COX-2 expression in HPEC at transcriptional level.	Hydrogen Peroxide	12-29	interleukin 1 beta	Homo sapiens	42-50
14667219-4	2003	One of the most potent compounds, among others, was (4-[(2-aminophenyl)amino]-2-chlorophenyl)(2-methylphenyl)methanone (45) with IC(50) values of 14 and 6 nM for the inhibition of IL-1beta and TNF-alpha, respectively.	4-(((2-aminophenyl)amino)-2-chlorophenyl)(2-methylphenyl)methanone	52-118	interleukin 1 beta	Homo sapiens	180-188
14643170-5	2004	Pre-treatment with beclomethasone, budesonide or fluticasone reduced TNFalpha- and IL-1beta-stimulated IL-8 and RANTES release from HASMC in a dose dependent manner.	Beclomethasone	19-33	interleukin 1 beta	Homo sapiens	83-91
14643170-5	2004	Pre-treatment with beclomethasone, budesonide or fluticasone reduced TNFalpha- and IL-1beta-stimulated IL-8 and RANTES release from HASMC in a dose dependent manner.	Budesonide	35-45	interleukin 1 beta	Homo sapiens	83-91
14643170-5	2004	Pre-treatment with beclomethasone, budesonide or fluticasone reduced TNFalpha- and IL-1beta-stimulated IL-8 and RANTES release from HASMC in a dose dependent manner.	Fluticasone	49-60	interleukin 1 beta	Homo sapiens	83-91
14643170-5	2004	Pre-treatment with beclomethasone, budesonide or fluticasone reduced TNFalpha- and IL-1beta-stimulated IL-8 and RANTES release from HASMC in a dose dependent manner.	hasmc	132-137	interleukin 1 beta	Homo sapiens	83-91
14643170-7	2004	TNFalpha- and IL-1beta-induced RANTES and IL-8 expression was reduced on the transcriptional level by pre-treatment with fluticasone and budesonide.	Fluticasone	121-132	interleukin 1 beta	Homo sapiens	14-22
14643170-7	2004	TNFalpha- and IL-1beta-induced RANTES and IL-8 expression was reduced on the transcriptional level by pre-treatment with fluticasone and budesonide.	Budesonide	137-147	interleukin 1 beta	Homo sapiens	14-22
14664905-0	2003	Acetaminophen down-regulates interleukin-1beta-induced nuclear factor-kappaB nuclear translocation in a human astrocytic cell line.	Acetaminophen	0-13	interleukin 1 beta	Homo sapiens	29-46
14664905-1	2003	In previous studies performed to elucidate acetaminophen mechanism of action, we demonstrated that acetaminophen inhibits prostaglandin E2 production by interleukin (IL)-1beta-stimulated T98G human astrocytic cells, without affecting cyclooxygenase-2 enzymatic activity.	Acetaminophen	99-112	interleukin 1 beta	Homo sapiens	153-175
14664905-1	2003	In previous studies performed to elucidate acetaminophen mechanism of action, we demonstrated that acetaminophen inhibits prostaglandin E2 production by interleukin (IL)-1beta-stimulated T98G human astrocytic cells, without affecting cyclooxygenase-2 enzymatic activity.	Dinoprostone	122-138	interleukin 1 beta	Homo sapiens	153-175
14664905-5	2003	These data indicate that therapeutic concentrations of acetaminophen induce an inhibition of IL-1beta-dependent NF-kappaB nuclear translocation.	Acetaminophen	55-68	interleukin 1 beta	Homo sapiens	93-101
14667219-3	2003	Our initial lead, (4-[(2-aminophenyl)amino]phenyl)(phenyl)methanone (3), was systematically optimized and resulted in compounds that potently inhibited the release of the proinflammatory cytokines IL-1beta and TNF-alpha in human peripheral blood mononuclear cells stimulated by LPS.	(4-[(2-aminophenyl)amino]phenyl)(phenyl)methanone	18-67	interleukin 1 beta	Homo sapiens	197-205
14676104-10	2003	Moreover, both plasma and bronchoalveolar lavage fluid obtained from treated subjects significantly reduced the production of PGE2 that resulted when a lung cancer cell line, A549, was stimulated with IL-1beta or A23187.	Dinoprostone	126-130	interleukin 1 beta	Homo sapiens	201-209
14592852-4	2003	Two weeks after the operation, phorbol ester caused coronary spasm in vivo and coronary hypercontractions in vitro at the IL-1beta-treated segment; both were significantly inhibited by hydroxyfasudil, a specific Rho-kinase inhibitor.	Phorbol Esters	31-44	interleukin 1 beta	Homo sapiens	122-130
14592852-4	2003	Two weeks after the operation, phorbol ester caused coronary spasm in vivo and coronary hypercontractions in vitro at the IL-1beta-treated segment; both were significantly inhibited by hydroxyfasudil, a specific Rho-kinase inhibitor.	hydroxyfasudil	185-199	interleukin 1 beta	Homo sapiens	122-130
14673370-5	2003	Human nucleus pulposus has been shown to synthesize increased amounts of interleukin (IL)-6, prostaglandin E2 (PGE2), and nitric oxide in response to stimulation with IL-1beta.	Dinoprostone	93-109	interleukin 1 beta	Homo sapiens	167-175
14673370-5	2003	Human nucleus pulposus has been shown to synthesize increased amounts of interleukin (IL)-6, prostaglandin E2 (PGE2), and nitric oxide in response to stimulation with IL-1beta.	Dinoprostone	111-115	interleukin 1 beta	Homo sapiens	167-175
14673370-5	2003	Human nucleus pulposus has been shown to synthesize increased amounts of interleukin (IL)-6, prostaglandin E2 (PGE2), and nitric oxide in response to stimulation with IL-1beta.	Nitric Oxide	122-134	interleukin 1 beta	Homo sapiens	167-175
14595770-5	2003	Unilateral ibotenic acid lesions encompassing the ventral BNST significantly reduced both IL-1beta-induced increases in Fos immunoreactivity in corticotropin-releasing factor (CRF) cells of the hypothalamic paraventricular nucleus (PVN) and corresponding increases in adrenocorticotropic hormone (ACTH) secretion.	Ibotenic Acid	11-24	interleukin 1 beta	Homo sapiens	90-98
14723336-0	2003	Inhibition of IL-1beta and IL-6 in osteoblast-like cell by isoflavones extracted from Sophorae fructus.	Isoflavones	59-70	interleukin 1 beta	Homo sapiens	14-22
14723336-4	2003	Interestingly, IL-1beta and IL-6 mRNA were significantly suppressed in osteoblast-like cells treated with 17beta-estradiol (E2) and PIII when compared to positive control (SDB), and this suppression was more effective at 10(-8)% than at the highest concentration of 10(-4)%.	Estradiol	106-122	interleukin 1 beta	Homo sapiens	15-23
14630249-6	2003	Our results show that mainly (S)-(+)-flurbiprofen decreases, at therapeutically concentrations, the IL-1beta induced cartilage destruction.	Flurbiprofen	29-49	interleukin 1 beta	Homo sapiens	100-108
14563684-7	2003	Co-treatment with IL-1beta and budesonide potentiated the promoter activity at 30 min, an effect blocked by PD98059 and SB203580, PDTC, or deletion of the kappaB or GRE-like element.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	108-115	interleukin 1 beta	Homo sapiens	18-26
14714609-8	2003	The increased uPAR mRNA expression caused by IL-1beta was reduced to the basal level by treatment with 50 microM indomethacin.	Indomethacin	113-125	interleukin 1 beta	Homo sapiens	45-53
14563684-4	2003	Chromatin immunoprecipitation showed that co-treatment with IL-1beta and the glucocorticoid budesonide increased the SCF promoter occupancy by NF-kappaB and GR, as compared with IL-1beta and budesonide alone.	Budesonide	92-102	interleukin 1 beta	Homo sapiens	178-186
14563684-7	2003	Co-treatment with IL-1beta and budesonide potentiated the promoter activity at 30 min, an effect blocked by PD98059 and SB203580, PDTC, or deletion of the kappaB or GRE-like element.	SB 203580	120-128	interleukin 1 beta	Homo sapiens	18-26
15015724-0	2003	EI-2346, a novel interleukin-1beta converting enzyme inhibitor produced by Streptomyces sp.	EI-2346	0-7	interleukin 1 beta	Homo sapiens	17-34
15015724-3	2003	EI-2346, a novel interleukin-1beta converting enzyme (ICE) inhibitor, was isolated from the culture broths of Streptomyces sp.	EI-2346	0-7	interleukin 1 beta	Homo sapiens	17-34
14563684-4	2003	Chromatin immunoprecipitation showed that co-treatment with IL-1beta and the glucocorticoid budesonide increased the SCF promoter occupancy by NF-kappaB and GR, as compared with IL-1beta and budesonide alone.	Budesonide	191-201	interleukin 1 beta	Homo sapiens	60-68
14563684-5	2003	In reporter gene assays, IL-1beta time-dependently increased the promoter activity, which was abolished by either pre-treatment with the MAP kinase inhibitors PD98059 (MEK) and SB203580 (p38), pre-treatment with the NF-kappaB inhibitor PDTC, or deletion of the kappaB site.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	159-166	interleukin 1 beta	Homo sapiens	25-33
14563684-5	2003	In reporter gene assays, IL-1beta time-dependently increased the promoter activity, which was abolished by either pre-treatment with the MAP kinase inhibitors PD98059 (MEK) and SB203580 (p38), pre-treatment with the NF-kappaB inhibitor PDTC, or deletion of the kappaB site.	SB 203580	177-185	interleukin 1 beta	Homo sapiens	25-33
14613235-10	2003	Finally, LPS-induced IL1 beta secretion was measured from palladium-treated and control cells.	Palladium	58-67	interleukin 1 beta	Homo sapiens	21-29
14566967-4	2003	The protective effect of IL-1beta was abrogated by the nitric oxide (NO) synthesis inhibitor N-monomethyl-l-arginine (L-NMMA) while apoptosis stimulation was not affected.	Nitric Oxide	55-67	interleukin 1 beta	Homo sapiens	25-33
14566967-4	2003	The protective effect of IL-1beta was abrogated by the nitric oxide (NO) synthesis inhibitor N-monomethyl-l-arginine (L-NMMA) while apoptosis stimulation was not affected.	omega-N-Methylarginine	93-116	interleukin 1 beta	Homo sapiens	25-33
14566967-4	2003	The protective effect of IL-1beta was abrogated by the nitric oxide (NO) synthesis inhibitor N-monomethyl-l-arginine (L-NMMA) while apoptosis stimulation was not affected.	omega-N-Methylarginine	118-124	interleukin 1 beta	Homo sapiens	25-33
14566967-6	2003	Pyrrolidine dithiocarbamate (PDTC), a scavenger of reactive oxygen species (ROS) blocked apoptosis induction by CH-11/PSI as well as the enhancement by IL-1beta.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Homo sapiens	152-160
14566967-6	2003	Pyrrolidine dithiocarbamate (PDTC), a scavenger of reactive oxygen species (ROS) blocked apoptosis induction by CH-11/PSI as well as the enhancement by IL-1beta.	pyrrolidine dithiocarbamic acid	29-33	interleukin 1 beta	Homo sapiens	152-160
14566967-6	2003	Pyrrolidine dithiocarbamate (PDTC), a scavenger of reactive oxygen species (ROS) blocked apoptosis induction by CH-11/PSI as well as the enhancement by IL-1beta.	Reactive Oxygen Species	51-74	interleukin 1 beta	Homo sapiens	152-160
14566967-6	2003	Pyrrolidine dithiocarbamate (PDTC), a scavenger of reactive oxygen species (ROS) blocked apoptosis induction by CH-11/PSI as well as the enhancement by IL-1beta.	Reactive Oxygen Species	76-79	interleukin 1 beta	Homo sapiens	152-160
14566967-8	2003	In conclusion, IL-1beta augments CH-11/PSI induced apoptosis in the majority of chondrocyte samples.	4-dimethylamino-3',4'-dimethoxychalcone	33-38	interleukin 1 beta	Homo sapiens	15-23
14733715-0	2003	Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells.	Nitric Oxide	87-99	interleukin 1 beta	Homo sapiens	60-77
14733715-4	2003	We have previously shown that the proinflammatory cytokine, interleukin-1beta (IL-1beta), can stimulate the production of nitric oxide (NO) in cultured lacrimal gland acinar cells.	Nitric Oxide	122-134	interleukin 1 beta	Homo sapiens	60-77
14974816-5	2003	Little is known about IL-1beta-stimulated AgP fibroblast IL-6 and PGE2 production and their regulation by COX inhibitors.	Dinoprostone	66-70	interleukin 1 beta	Homo sapiens	22-30
14733715-4	2003	We have previously shown that the proinflammatory cytokine, interleukin-1beta (IL-1beta), can stimulate the production of nitric oxide (NO) in cultured lacrimal gland acinar cells.	Nitric Oxide	122-134	interleukin 1 beta	Homo sapiens	79-87
29539078-5	2003	Little is known about IL-1beta-stimulated AgP fibroblast IL-6 and PGE2 production and their regulation by COX inhibitors.	Dinoprostone	66-70	interleukin 1 beta	Homo sapiens	22-30
29539078-6	2003	The objective of this study was to determine the effects of COX-2 inhibitors on amounts of PGE2 and IL-6 made by IL-1beta-stimulated gingival fibroblasts.	Dinoprostone	91-95	interleukin 1 beta	Homo sapiens	113-121
29539078-10	2003	When exogenous PGE2 was added concurrently with COX-2 inhibitors before addition of IL-1beta, IL-6 production returned to levels at or approaching that produced by cells exposed only to IL-1beta (P &lt;=0.04).	Dinoprostone	15-19	interleukin 1 beta	Homo sapiens	186-194
14651596-3	2003	Exposure of innervated longitudinal colonic muscle strips to IL-1beta for 8 h increased SP synthesis in, and greater SP release from excitatory motor neurones in response to KCl or electrical field stimulation (EFS), and enhanced longitudinal muscle contraction in response to EFS.	Potassium Chloride	174-177	interleukin 1 beta	Homo sapiens	61-69
14690293-2	2003	N-acetylcysteine and diclofenac were most effective in suppressing TNF-alpha and IL-1beta expression by the monocyte-macrophages.	Acetylcysteine	0-16	interleukin 1 beta	Homo sapiens	81-89
14690293-2	2003	N-acetylcysteine and diclofenac were most effective in suppressing TNF-alpha and IL-1beta expression by the monocyte-macrophages.	Diclofenac	21-31	interleukin 1 beta	Homo sapiens	81-89
14645533-3	2003	By transfection with various COX-2 promoter reporter constructs, we found that the bp -327-to-+59 promoter region was essential for COX-2 gene transcription by bradykinin and IL-1beta and that the cyclic AMP response element (CRE) was critical in bradykinin-induced transcription, whereas nuclear factor IL-6 and CRE and, to a lesser extent, nuclear factor-kappaB (NF-kappaB) were involved in IL-1beta-induced transcription.	Cyclic AMP	197-207	interleukin 1 beta	Homo sapiens	393-401
14645533-6	2003	We also revealed that endogenous prostaglandin E(2) was critical in bradykinin-induced COX-2 transcription initiation and involved in IL-1beta-induced COX-2 transcription at a latter stage.	Dinoprostone	33-51	interleukin 1 beta	Homo sapiens	134-142
14974816-6	2003	The objective of this study was to determine the effects of COX-2 inhibitors on amounts of PGE2 and IL-6 made by IL-1beta-stimulated gingival fibroblasts.	Dinoprostone	91-95	interleukin 1 beta	Homo sapiens	113-121
14974816-10	2003	When exogenous PGE2 was added concurrently with COX-2 inhibitors before addition of IL-1beta, IL-6 production returned to levels at or approaching that produced by cells exposed only to IL-1beta (P &lt; or = 0.04).	Dinoprostone	15-19	interleukin 1 beta	Homo sapiens	186-194
14712517-3	2003	RESULT: (1) Pretreatment with IL-1 beta and LPS markedly suppressed CCNU cytotoxicity in BT-325 cells with a significant increase in NO production (P&lt;0.05).	sulfaperine	89-95	interleukin 1 beta	Homo sapiens	30-39
14644623-6	2003	Our results revealed that low concentrations (1-10 microg/ml) of gallium promoted cells to enter the S phase of cell cycle and enhanced cellular release of tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma, both in vitro and in vivo.	Gallium	65-72	interleukin 1 beta	Homo sapiens	185-202
14530076-12	2003	At the cellular level, there was an even higher correlation between the quantity of metal particles and the production of IL-1beta and IL-6 (r=-0.99), while TNF-alpha did not demonstrate any correlation, remaining at very low levels.	Metals	84-89	interleukin 1 beta	Homo sapiens	122-130
14647459-4	2003	OVCAR-3 cells showed a constitutive expression of COX-1 and an induction of high levels of COX-2 and PGE(2) after stimulation with interleukin-1beta.	Prostaglandins E	101-104	interleukin 1 beta	Homo sapiens	131-148
14692429-9	2003	CONCLUSIONS: Amphotericin B induces the production of TNF-alpha, interferon-gamma, and IL-1beta, which may potentiate its toxic effects.	Amphotericin B	13-27	interleukin 1 beta	Homo sapiens	87-95
14551150-7	2003	As a result, IL-1beta contributed significantly to the amount of BH4 produced (+40%) but concomitantly reduced the accumulation of the GTPCH intermediate, 7,8-dihydroneopterin triphosphate (-50%).	sapropterin	65-68	interleukin 1 beta	Homo sapiens	13-21
14613276-9	2003	Furthermore, culture media from cells treated with interleukin-1beta (to generate NO and NO(2) (-)) offered significantly more protection against HOCl-mediated cytotoxicity than culture media from untreated cells.	Hypochlorous Acid	146-150	interleukin 1 beta	Homo sapiens	51-68
14551150-7	2003	As a result, IL-1beta contributed significantly to the amount of BH4 produced (+40%) but concomitantly reduced the accumulation of the GTPCH intermediate, 7,8-dihydroneopterin triphosphate (-50%).	dihydroneopterin triphosphate	155-188	interleukin 1 beta	Homo sapiens	13-21
14746807-7	2003	In addition, caffeic acid phenethyl ester (CAPE), a specific inhibitor of the activation of NF-kappaB, not only abolished IL-1beta-mediated NF-kappaB promoter activation, but also blocked IL-1beta-induced MIP-1beta expression.	caffeic acid phenethyl ester	13-41	interleukin 1 beta	Homo sapiens	122-130
14746807-7	2003	In addition, caffeic acid phenethyl ester (CAPE), a specific inhibitor of the activation of NF-kappaB, not only abolished IL-1beta-mediated NF-kappaB promoter activation, but also blocked IL-1beta-induced MIP-1beta expression.	caffeic acid phenethyl ester	13-41	interleukin 1 beta	Homo sapiens	188-196
14642127-6	2003	RESULTS: After 96 hours exposure to arsenic trioxide, 10 - 6 mol/L in vitro or 10 mg/d in vivo, APL cells showed a significant increase of IL-1(beta) (P &lt; 0.05) and G-CSF (P &lt; 0.05) production, and a significant decrease of IL-6 (P &lt; 0.05) and IL-8 (P &lt; 0.05).	Arsenic Trioxide	36-52	interleukin 1 beta	Homo sapiens	139-149
14642127-10	2003	CONCLUSION: IL-1(beta) and G-CSF secretion may play an important role in the proliferation of APL cells after exposure to arsenic trioxide.	Arsenic Trioxide	122-138	interleukin 1 beta	Homo sapiens	12-22
14746807-7	2003	In addition, caffeic acid phenethyl ester (CAPE), a specific inhibitor of the activation of NF-kappaB, not only abolished IL-1beta-mediated NF-kappaB promoter activation, but also blocked IL-1beta-induced MIP-1beta expression.	caffeic acid phenethyl ester	43-47	interleukin 1 beta	Homo sapiens	122-130
14746807-7	2003	In addition, caffeic acid phenethyl ester (CAPE), a specific inhibitor of the activation of NF-kappaB, not only abolished IL-1beta-mediated NF-kappaB promoter activation, but also blocked IL-1beta-induced MIP-1beta expression.	caffeic acid phenethyl ester	43-47	interleukin 1 beta	Homo sapiens	188-196
12959973-1	2003	Systemic or intratesticular release of TNF alpha and IL1 beta have been implicated in the reduced testosterone biosynthesis and impaired production of competent spermatozoa found in human patients suffering from sepsis or chronic inflammation.	Testosterone	98-110	interleukin 1 beta	Homo sapiens	53-61
14568957-11	2003	SB203580 also inhibited LPS-induced production of IL-1beta, IL-10, and TNF-alpha; enhanced IL-12 production; and recovered the activity of ERK and NF-kappaB.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	50-58
14671485-9	2003	Both doses of UR-12746S decreased IL-1beta production, while only the highest dose assayed inhibited TNFalpha production.	dersalazine	14-23	interleukin 1 beta	Homo sapiens	34-42
15031635-3	2003	GST and CQ were equally effective in reducing lipopolysaccharide (LPS)-induced IL-1 beta release while CQ was a more effective inhibitor of TNF-alpha production than GST.	Chloroquine	8-10	interleukin 1 beta	Homo sapiens	79-88
15031635-8	2003	These data demonstrate that CQ inhibits IL-1 beta release from monocytes by interfering with pretranscriptional signaling and TNF-alpha release by posttranslational events whereas GST downregulates IL-1 beta secretion by interfering with posttranslational IL-1 beta processing.	Chloroquine	28-30	interleukin 1 beta	Homo sapiens	40-49
14671485-11	2003	This inhibitory effect was enhanced when both compounds were administered simultaneously at 10(-4) M. In addition, UR-12715 inhibited IL-1beta or TNFalpha production in THP-1 or U937 cells, respectively, when these cells were stimulated by PMA and LPS; whereas 5-ASA only showed a weak effect in inhibiting IL-1beta production.	1-((1-(3-(4-aminophenyl)-3-phenylpropenoyl)-4-piperidyl)methyl)-1H-2-methylimidazo(4,5-c)pyridine	115-123	interleukin 1 beta	Homo sapiens	134-142
14671485-11	2003	This inhibitory effect was enhanced when both compounds were administered simultaneously at 10(-4) M. In addition, UR-12715 inhibited IL-1beta or TNFalpha production in THP-1 or U937 cells, respectively, when these cells were stimulated by PMA and LPS; whereas 5-ASA only showed a weak effect in inhibiting IL-1beta production.	1-((1-(3-(4-aminophenyl)-3-phenylpropenoyl)-4-piperidyl)methyl)-1H-2-methylimidazo(4,5-c)pyridine	115-123	interleukin 1 beta	Homo sapiens	307-315
12975482-1	2003	In the course of other experiments, we serendipitously observed that extracellular nicotinamide adenine dinucleotide (NAD+) ameliorated the development of epithelial hyperpermeability when monolayers of Caco-2 enterocyte-like cells were incubated with cytomix, a mixture containing interferon-gamma, interleukin-1beta, and tumor necrosis factor-alpha.	NAD	83-116	interleukin 1 beta	Homo sapiens	300-317
14603501-4	2003	Significant reductions in the MDR1-mediated efflux of Rhodamine 123 and MDR1 mRNA levels were observed in HuH 7 cells treated with IL-6, TNF-alpha, or IL-1beta and in TNF-alpha-treated HepG2 cells.	Rhodamine 123	54-67	interleukin 1 beta	Homo sapiens	151-159
12975482-1	2003	In the course of other experiments, we serendipitously observed that extracellular nicotinamide adenine dinucleotide (NAD+) ameliorated the development of epithelial hyperpermeability when monolayers of Caco-2 enterocyte-like cells were incubated with cytomix, a mixture containing interferon-gamma, interleukin-1beta, and tumor necrosis factor-alpha.	NAD	118-122	interleukin 1 beta	Homo sapiens	300-317
14586044-10	2003	Resveratrol reduced IL-1beta stimulated IL-8 and GM-CSF release in both smokers and COPD patients to below basal levels.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	20-28
14595579-5	2003	Treatment of amnion cells with IL-1beta (0.01-10 ng/mL) resulted in a significant increase in PGE(2) release.	Prostaglandins E	94-97	interleukin 1 beta	Homo sapiens	31-39
14595579-6	2003	Incubation of the cells with the extract for 24 h significantly inhibited IL-1beta-induced PGE(2) production.	Prostaglandins E	91-94	interleukin 1 beta	Homo sapiens	74-82
14580366-0	2003	Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells.	15-deoxy-delta12	10-26	interleukin 1 beta	Homo sapiens	50-58
14580366-0	2003	Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells.	14-prostaglandin j2	27-46	interleukin 1 beta	Homo sapiens	50-58
14580366-5	2003	We examined the effect of 15d-PGJ(2) on the expression of ENA-78 in cultured endothelial cells stimulated with IL-1beta.	15d-pgj	26-33	interleukin 1 beta	Homo sapiens	111-119
14580366-6	2003	15d-PGJ(2) inhibited the IL-1beta-induced expression of ENA-78, but not the expression of IL-8 or GRO-alpha in response to IL-1.	15d-pgj	0-7	interleukin 1 beta	Homo sapiens	25-33
14580366-6	2003	15d-PGJ(2) inhibited the IL-1beta-induced expression of ENA-78, but not the expression of IL-8 or GRO-alpha in response to IL-1.	15d-pgj	0-7	interleukin 1 beta	Homo sapiens	25-29
14728887-13	2003	CONCLUSION: Curcumin could inhibit the human mesangial cell proliferation and alter the extracellular matrix turnover, meanwhile it could down-regulate the IL-1 beta and MCP-1 mRNA expression induced by LPS, which may be valuable in decreasing the progression of glomerulosclerosis.	Curcumin	12-20	interleukin 1 beta	Homo sapiens	156-165
12898248-3	2003	Treatment of HPMC with IL-1beta and TNF-alpha resulted in a time- and dose-dependent alteration of the normal cobblestone morphology of the mesothelium with loss of polarization, cellular retraction and exposure of the submesothelial matrix.	cobblestone	110-121	interleukin 1 beta	Homo sapiens	23-31
14646600-4	2003	Effect of the ATRA treatment was demonstrated by the concomitant induction of cd14 and il1beta genes in four patients.	Tretinoin	14-18	interleukin 1 beta	Homo sapiens	87-94
14523996-0	2003	Sodium arsenite downregulates transcriptional activity of AP-1 and CRE binding proteins in IL-1beta-treated Caco-2 cells by increasing the expression of the transcriptional repressor CREMalpha.	sodium arsenite	0-15	interleukin 1 beta	Homo sapiens	91-99
12810931-0	2003	Ciprofloxacin reduces the stimulation of prostaglandin E(2) output by interleukin-1beta in human tendon-derived cells.	Ciprofloxacin	0-13	interleukin 1 beta	Homo sapiens	70-87
12810931-0	2003	Ciprofloxacin reduces the stimulation of prostaglandin E(2) output by interleukin-1beta in human tendon-derived cells.	Dinoprostone	41-59	interleukin 1 beta	Homo sapiens	70-87
12810931-5	2003	RESULTS: IL-1beta stimulated a substantial and prolonged increase in the output of PGE2.	Dinoprostone	83-87	interleukin 1 beta	Homo sapiens	9-17
12810931-6	2003	Preincubation with ciprofloxacin reduced IL-1beta-induced PGE2 output at all times tested; the reduction at 48 h was 69% (99% confidence interval 59-79%; 15 experiments).	Ciprofloxacin	19-32	interleukin 1 beta	Homo sapiens	41-49
12810931-6	2003	Preincubation with ciprofloxacin reduced IL-1beta-induced PGE2 output at all times tested; the reduction at 48 h was 69% (99% confidence interval 59-79%; 15 experiments).	Dinoprostone	58-62	interleukin 1 beta	Homo sapiens	41-49
12810931-8	2003	However, ciprofloxacin did not affect the induction of COX-2 by IL-1beta, measured at 4 or 48 h. CONCLUSIONS: Ciprofloxacin reduces IL-1beta-induced PGE2 output in tendon-derived cells.	Ciprofloxacin	110-123	interleukin 1 beta	Homo sapiens	132-140
12810931-8	2003	However, ciprofloxacin did not affect the induction of COX-2 by IL-1beta, measured at 4 or 48 h. CONCLUSIONS: Ciprofloxacin reduces IL-1beta-induced PGE2 output in tendon-derived cells.	Dinoprostone	149-153	interleukin 1 beta	Homo sapiens	132-140
12810931-9	2003	The reduction in PGE2 output could modulate various cellular activities of IL-1beta, and may be implicated in fluoroquinolone-induced tendinopathy.	Dinoprostone	17-21	interleukin 1 beta	Homo sapiens	75-83
14523996-3	2003	We tested the effect of SA on the activity of CCAAT/enhancer binding protein (C/EBP), activating protein-1 (AP-1), and CRE binding proteins in IL-1beta-treated Caco-2 cells.	sodium arsenite	24-26	interleukin 1 beta	Homo sapiens	143-151
12888570-4	2003	Specificity of IL-1 beta effects on COL2A1 promoter activity was demonstrated in experiments in which transfection of a wild type -50/+1 sequence of COL2A1 promoter as a decoy oligonucleotide abolished the IL-1 beta inhibition of a -63/+47 COL2A1-mediated transcription.	Oligonucleotides	176-191	interleukin 1 beta	Homo sapiens	15-24
12832416-8	2003	Only a small group of genes, namely pent(r)axin-3, CXCL10, ICAM-1, and IL-1 beta, was inhibited by both the c-JUN peptide and the JNK inhibitor SP600125.	pyrazolanthrone	144-152	interleukin 1 beta	Homo sapiens	71-80
12888570-4	2003	Specificity of IL-1 beta effects on COL2A1 promoter activity was demonstrated in experiments in which transfection of a wild type -50/+1 sequence of COL2A1 promoter as a decoy oligonucleotide abolished the IL-1 beta inhibition of a -63/+47 COL2A1-mediated transcription.	Oligonucleotides	176-191	interleukin 1 beta	Homo sapiens	206-215
12855693-3	2003	This study also demonstrates that two well established activators of AA release and prostanoid synthesis, the cytokine, interleukin-1beta (IL-1beta), and the calcium ionophore, A23187, induce an increase in C-1-P levels within the relevant time-frame of AA release.	Prostaglandins	84-94	interleukin 1 beta	Homo sapiens	120-137
14504184-8	2003	The change in IL-1beta levels correlated with the change in sP-selectin in patients randomized to either simvastatin (Rho, 0.42; P&lt;0.05) or aspirin (Rho, 0.42; P&lt;0.05).	Simvastatin	105-116	interleukin 1 beta	Homo sapiens	14-22
14504184-8	2003	The change in IL-1beta levels correlated with the change in sP-selectin in patients randomized to either simvastatin (Rho, 0.42; P&lt;0.05) or aspirin (Rho, 0.42; P&lt;0.05).	Aspirin	143-150	interleukin 1 beta	Homo sapiens	14-22
12855693-3	2003	This study also demonstrates that two well established activators of AA release and prostanoid synthesis, the cytokine, interleukin-1beta (IL-1beta), and the calcium ionophore, A23187, induce an increase in C-1-P levels within the relevant time-frame of AA release.	Prostaglandins	84-94	interleukin 1 beta	Homo sapiens	139-147
12855693-3	2003	This study also demonstrates that two well established activators of AA release and prostanoid synthesis, the cytokine, interleukin-1beta (IL-1beta), and the calcium ionophore, A23187, induce an increase in C-1-P levels within the relevant time-frame of AA release.	Calcimycin	177-183	interleukin 1 beta	Homo sapiens	139-147
12855693-3	2003	This study also demonstrates that two well established activators of AA release and prostanoid synthesis, the cytokine, interleukin-1beta (IL-1beta), and the calcium ionophore, A23187, induce an increase in C-1-P levels within the relevant time-frame of AA release.	ceramide 1-phosphate	207-212	interleukin 1 beta	Homo sapiens	120-137
12855693-3	2003	This study also demonstrates that two well established activators of AA release and prostanoid synthesis, the cytokine, interleukin-1beta (IL-1beta), and the calcium ionophore, A23187, induce an increase in C-1-P levels within the relevant time-frame of AA release.	ceramide 1-phosphate	207-212	interleukin 1 beta	Homo sapiens	139-147
12855693-4	2003	Furthermore, the enzyme responsible for the production of C-1-P in mammalian cells, ceramide kinase, was activated in response to IL-1beta and A23187.	ceramide 1-phosphate	58-63	interleukin 1 beta	Homo sapiens	130-138
14558087-8	2003	RESULTS: The enhanced expression of mPGES mRNA and protein in IL-1beta-stimulated RASFs was attenuated by the addition of indomethacin, NS-398, rofecoxib, or meloxicam.	Indomethacin	122-134	interleukin 1 beta	Homo sapiens	62-70
12967678-3	2003	Both untreated and IL-1beta-treated HUVEC were exposed to various NOS inhibitors and NO donors in short-term (1 or 3 hours) experiments, and the effects on prostanoid production were evaluated through the measurement of prostaglandins (PG) I2, E2 and F2alpha released in the incubation medium.	Prostaglandins	156-166	interleukin 1 beta	Homo sapiens	19-27
12967678-4	2003	We found that the inhibition of inducible NOS but not endothelial NOS antagonizes the IL-1beta-induced increase in PGI2 release.	Epoprostenol	115-119	interleukin 1 beta	Homo sapiens	86-94
12967678-6	2003	Pharmacological levels of NO, obtained with various NO donors, inhibit basal and IL-1beta-stimulated PG release.	Prostaglandins	101-103	interleukin 1 beta	Homo sapiens	81-89
14558087-0	2003	Prostaglandin E2 is an enhancer of interleukin-1beta-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	35-52
14558087-8	2003	RESULTS: The enhanced expression of mPGES mRNA and protein in IL-1beta-stimulated RASFs was attenuated by the addition of indomethacin, NS-398, rofecoxib, or meloxicam.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	136-142	interleukin 1 beta	Homo sapiens	62-70
14558087-8	2003	RESULTS: The enhanced expression of mPGES mRNA and protein in IL-1beta-stimulated RASFs was attenuated by the addition of indomethacin, NS-398, rofecoxib, or meloxicam.	rofecoxib	144-153	interleukin 1 beta	Homo sapiens	62-70
14558087-8	2003	RESULTS: The enhanced expression of mPGES mRNA and protein in IL-1beta-stimulated RASFs was attenuated by the addition of indomethacin, NS-398, rofecoxib, or meloxicam.	Meloxicam	158-167	interleukin 1 beta	Homo sapiens	62-70
14558087-10	2003	IL-1beta-induced PGES activity, measured by conversion of PGH(2) to PGE(2), was decreased by rofecoxib.	Prostaglandin H2	58-64	interleukin 1 beta	Homo sapiens	0-8
14558087-10	2003	IL-1beta-induced PGES activity, measured by conversion of PGH(2) to PGE(2), was decreased by rofecoxib.	Prostaglandins E	17-20	interleukin 1 beta	Homo sapiens	0-8
14558087-10	2003	IL-1beta-induced PGES activity, measured by conversion of PGH(2) to PGE(2), was decreased by rofecoxib.	rofecoxib	93-102	interleukin 1 beta	Homo sapiens	0-8
14558087-14	2003	Intracellular cAMP was increased by IL-1beta and was inhibited by rofecoxib.	Cyclic AMP	14-18	interleukin 1 beta	Homo sapiens	36-44
14612199-10	2003	Cell proliferation was increased by IL-1 beta as determined by bromodesoxyuridine incorporation.	bromodesoxyuridine	63-81	interleukin 1 beta	Homo sapiens	36-45
14510824-3	2003	Previous evidence in a Japanese population shows that the homozygotes for allele 2 at position -511 of the interleukin (IL)-1 beta gene promoter region (IL-1 beta-511*2/2) confers susceptibility to the development of HS.	Hydrogen	217-219	interleukin 1 beta	Homo sapiens	107-130
14612213-5	2003	Both fenofibrate and simvastatin markedly reduced plasma levels of high-sensitivity CRP, IL-1 beta, and sCD40L, and improved endothelium-dependent FMD without mutual differences.	Fenofibrate	5-16	interleukin 1 beta	Homo sapiens	89-98
14612213-5	2003	Both fenofibrate and simvastatin markedly reduced plasma levels of high-sensitivity CRP, IL-1 beta, and sCD40L, and improved endothelium-dependent FMD without mutual differences.	Simvastatin	21-32	interleukin 1 beta	Homo sapiens	89-98
14555589-7	2003	DEX inhibited the spontaneous release of TNF-alpha (p &lt; 0.001), sTNFR2 (p &lt; 0.05), IL-1 beta (p &lt; 0.05), and IL-10 (p &lt; 0.01).	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	89-98
14504184-9	2003	In contrast, the simvastatin-induced change in IL-1beta did not correlate with the change in CRP levels.	Simvastatin	17-28	interleukin 1 beta	Homo sapiens	47-55
14522842-4	2003	oATP decreased by 40-70% the secretion of interleukin (IL)-8 stimulated by tumor necrosis factor-alpha (TNF-alpha) in all three cell types, by IL-1beta in HUVEC and 1321N1 cells, and by endotoxin in HUVEC.	2',3'-dialdehyde ATP	0-4	interleukin 1 beta	Homo sapiens	143-151
14510824-3	2003	Previous evidence in a Japanese population shows that the homozygotes for allele 2 at position -511 of the interleukin (IL)-1 beta gene promoter region (IL-1 beta-511*2/2) confers susceptibility to the development of HS.	Hydrogen	217-219	interleukin 1 beta	Homo sapiens	153-162
14568676-4	2003	In particular, we demonstrate that exogenous NO inhibits PGE2 release evoked by IL-1beta whereas high levels of the prostanoid, in the presence of proinflammatory agents, exert a negative feed-back control on iNOS mRNA expression, possibly through a cAMP-dependent mechanism.	Dinoprostone	57-61	interleukin 1 beta	Homo sapiens	80-88
12760902-11	2003	IL-1beta and TGF-beta1 induced an activation of ERK p42/44 and p38 MAP kinases, and the MAP kinase inhibitors (SB-202190, PD-98059, and U-0216) significantly reduced the IL-1beta- and TGF-beta1-induced IL-11 secretion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	122-130	interleukin 1 beta	Homo sapiens	0-8
14515062-0	2003	Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men.	Pravastatin	111-122	interleukin 1 beta	Homo sapiens	0-14
14515062-2	2003	We used positron emission tomography (PET) to study whether coronary reactivity or its response to pravastatin is related to this IL-1B polymorphism.	Pravastatin	99-110	interleukin 1 beta	Homo sapiens	130-135
14515062-9	2003	In the pravastatin group, the ASMF increased by 18.0% in subjects with IL-1B A2- (n=7), but decreased by 2% in subjects with IL-1B A2+ (n=7).	Pravastatin	7-18	interleukin 1 beta	Homo sapiens	71-76
14515062-9	2003	In the pravastatin group, the ASMF increased by 18.0% in subjects with IL-1B A2- (n=7), but decreased by 2% in subjects with IL-1B A2+ (n=7).	Pravastatin	7-18	interleukin 1 beta	Homo sapiens	125-130
14515062-9	2003	In the pravastatin group, the ASMF increased by 18.0% in subjects with IL-1B A2- (n=7), but decreased by 2% in subjects with IL-1B A2+ (n=7).	asmf	30-34	interleukin 1 beta	Homo sapiens	71-76
14515062-12	2003	In conclusion, coronary function improves after 6 months of pravastatin therapy in subjects with the IL-1B A2- allele but not in those with the IL-1B A2+ allele.	Pravastatin	60-71	interleukin 1 beta	Homo sapiens	101-106
12763754-1	2003	Previously we found that interleukin-1beta (IL-1beta)-activated inducible nitric oxide (NO) synthase (iNOS) expression and that NO production can trigger cardiac fibroblast (CFb) apoptosis.	nitric	74-80	interleukin 1 beta	Homo sapiens	25-42
12763754-1	2003	Previously we found that interleukin-1beta (IL-1beta)-activated inducible nitric oxide (NO) synthase (iNOS) expression and that NO production can trigger cardiac fibroblast (CFb) apoptosis.	nitric	74-80	interleukin 1 beta	Homo sapiens	44-52
12763754-6	2003	These data demonstrate that ANG II protection of CFbs from IL-1beta-induced apoptosis is associated with downregulation of iNOS expression and requires an intact phosphatidylinositol 3-kinase-Akt survival signal pathway.	Clofibrate	49-53	interleukin 1 beta	Homo sapiens	59-67
12760902-11	2003	IL-1beta and TGF-beta1 induced an activation of ERK p42/44 and p38 MAP kinases, and the MAP kinase inhibitors (SB-202190, PD-98059, and U-0216) significantly reduced the IL-1beta- and TGF-beta1-induced IL-11 secretion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	122-130	interleukin 1 beta	Homo sapiens	170-178
12958195-0	2003	A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA.	K 7174	27-33	interleukin 1 beta	Homo sapiens	61-69
14586711-4	2003	Following renal injury with phenol, the abundance of IL-1Beta and neuronal isoform of nitric oxide synthase (nNOS) in the brain decreased, and this may mediate the rise in SNS activity.	Phenol	28-34	interleukin 1 beta	Homo sapiens	53-61
12934070-1	2003	The potassium ionophore nigericin induces cell death and promotes the maturation and release of IL-1beta in lipopolysaccharide (LPS)-primed monocytes and macrophages, the latter depending on caspase-1 activation by an unknown mechanism.	Potassium	4-13	interleukin 1 beta	Homo sapiens	96-104
12934070-1	2003	The potassium ionophore nigericin induces cell death and promotes the maturation and release of IL-1beta in lipopolysaccharide (LPS)-primed monocytes and macrophages, the latter depending on caspase-1 activation by an unknown mechanism.	Nigericin	24-33	interleukin 1 beta	Homo sapiens	96-104
12958195-3	2003	In this study, we examined the ability of K-7174 (a GATA-specific inhibitor) to improve Epo production when inhibited by treatment with IL-1beta, TNF-alpha, or L-NMMA.	K 7174	42-48	interleukin 1 beta	Homo sapiens	136-144
12958195-6	2003	Addition of 10 microM K-7174 rescued these inhibitions of Epo protein production and promoter activity induced by IL-1beta, TNF-alpha, or L-NMMA, respectively.	K 7174	22-28	interleukin 1 beta	Homo sapiens	114-122
13679195-5	2003	We measured in vitro the amount of glycosaminoglycans (GAGs) and the production of nitric oxide (NO) released into the culture medium of human articular cartilage treated with interleukin-1beta (IL-1beta), which promotes the cartilage destruction during articular disease.	Glycosaminoglycans	35-53	interleukin 1 beta	Homo sapiens	176-193
14620928-6	2003	An HMG-CoA reductase inhibitor (mevastatin, 10 micromol/l) attenuated the PAI-1 production induced by IL-1beta and IL-6.	mevastatin	32-42	interleukin 1 beta	Homo sapiens	102-110
13679195-5	2003	We measured in vitro the amount of glycosaminoglycans (GAGs) and the production of nitric oxide (NO) released into the culture medium of human articular cartilage treated with interleukin-1beta (IL-1beta), which promotes the cartilage destruction during articular disease.	Nitric Oxide	83-95	interleukin 1 beta	Homo sapiens	176-193
13679195-5	2003	We measured in vitro the amount of glycosaminoglycans (GAGs) and the production of nitric oxide (NO) released into the culture medium of human articular cartilage treated with interleukin-1beta (IL-1beta), which promotes the cartilage destruction during articular disease.	Nitric Oxide	83-95	interleukin 1 beta	Homo sapiens	195-203
13679195-6	2003	Leflunomide, in the presence of IL-1beta decreased NO production and GAGs release respect IL-1beta alone treated samples, in dose-related manner.	Leflunomide	0-11	interleukin 1 beta	Homo sapiens	32-40
13679195-6	2003	Leflunomide, in the presence of IL-1beta decreased NO production and GAGs release respect IL-1beta alone treated samples, in dose-related manner.	Leflunomide	0-11	interleukin 1 beta	Homo sapiens	90-98
13679195-7	2003	Our results suggest that leflunomide is able to protect cartilage matrix from degradative factors induced by IL-1beta with respect to methotrexate and leflunomide-methotrexate combination.	Leflunomide	25-36	interleukin 1 beta	Homo sapiens	109-117
15038780-5	2003	Dexamethasone significantly reduced IL-1 beta, IL-6, COX-2, and MMP-1 expression at high cell density.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	36-45
12939333-8	2003	A significantly greater increase of sodium fluorescein, horseradish peroxidase, and inulin permeability occurred in IL-1beta-supplemented medium than in standard medium.	Fluorescein	36-54	interleukin 1 beta	Homo sapiens	116-124
12958195-7	2003	Electrophoretic mobility shift assays revealed that addition of K-7174 decreased GATA binding activity, which was increased with the addition of IL-1beta, TNF-alpha, or L-NMMA.	K 7174	64-70	interleukin 1 beta	Homo sapiens	145-153
12954240-5	2003	RESULTS: The current data reveal that IL-1 beta significantly enhanced *NO and PGE(2)release for superficial chondrocytes, an effect reversed with L-NIO.	Dinoprostone	79-85	interleukin 1 beta	Homo sapiens	38-47
12915944-0	2003	IL1-beta and TNF-alpha induce changes in the nuclear polyphosphoinositide signalling system in osteoblasts similar to that occurring in patients with rheumatoid arthritis: an immunochemical and immunocytochemical study.	Phosphatidylinositol Phosphates	53-73	interleukin 1 beta	Homo sapiens	0-8
14694976-6	2003	Preterm neonates positive for IL-1beta in their initial sample were on prolonged assisted ventilation (38 vs. 16 days, p = 0.013) and oxygen supplementation (62 vs. 40.5 days, p = 0.0462) and required prolonged hospitalization (69 vs. 46 days, p = 0.0165).	Oxygen	134-140	interleukin 1 beta	Homo sapiens	30-38
12954240-0	2003	Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.	Nitric Oxide	61-73	interleukin 1 beta	Homo sapiens	32-41
12954240-0	2003	Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.	Dinoprostone	78-82	interleukin 1 beta	Homo sapiens	32-41
12954240-5	2003	RESULTS: The current data reveal that IL-1 beta significantly enhanced *NO and PGE(2)release for superficial chondrocytes, an effect reversed with L-NIO.	N(G)-iminoethylornithine	147-152	interleukin 1 beta	Homo sapiens	38-47
12954240-0	2003	Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.	Sepharose	128-135	interleukin 1 beta	Homo sapiens	32-41
12954240-1	2003	OBJECTIVE: To examine the effect of IL-1 beta-induced *NO and PGE(2)release by stimulated superficial and deep chondrocyte/agarose constructs subjected to mechanical compression.	Dinoprostone	62-68	interleukin 1 beta	Homo sapiens	36-45
12954240-11	2003	The dynamic compression-induced stimulation of 35SO(4)incorporation was enhanced with L-NIO for IL-1 beta-stimulated deep cells, indicating an *NO-dependent pathway.	35so(4)	47-54	interleukin 1 beta	Homo sapiens	96-105
12954240-1	2003	OBJECTIVE: To examine the effect of IL-1 beta-induced *NO and PGE(2)release by stimulated superficial and deep chondrocyte/agarose constructs subjected to mechanical compression.	Sepharose	123-130	interleukin 1 beta	Homo sapiens	36-45
12954240-11	2003	The dynamic compression-induced stimulation of 35SO(4)incorporation was enhanced with L-NIO for IL-1 beta-stimulated deep cells, indicating an *NO-dependent pathway.	N(G)-iminoethylornithine	86-91	interleukin 1 beta	Homo sapiens	96-105
12954240-12	2003	CONCLUSION: The present findings suggest that dynamic compression inhibits *NO and PGE(2)release in IL-1 beta-stimulated superficial cells via distinct pathways, a significant finding that may contribute to the development of intervention strategies for the treatment of inflammatory joint disorders.	Dinoprostone	83-89	interleukin 1 beta	Homo sapiens	100-109
12691958-6	2003	The stimulatory effect of UTP, but not ATP, in A549 cells is attenuated by preincubation with interleukin-1beta and interleukin-6, but not tumor necrosis factor-alpha.	Uridine Triphosphate	26-29	interleukin 1 beta	Homo sapiens	94-111
12813046-6	2003	SC-514 inhibits transcription of NF-kappa B-dependent genes in IL-1 beta-induced rheumatoid arthritis-derived synovial fibroblasts in a dose-dependent manner.	SC 514	0-6	interleukin 1 beta	Homo sapiens	63-72
14582585-0	2003	Effect of a triclosan-containing dental gel on the levels of prostaglandin I2 and interleukin-1beta in gingival crevicular fluid from adolescents with fixed orthodontic appliances.	Triclosan	12-21	interleukin 1 beta	Homo sapiens	82-99
12660148-2	2003	Efficient externalization of IL-1beta in macrophages and monocytes can occur via stimulation of P2X7 nucleotide receptors with extracellular ATP.	Adenosine Triphosphate	141-144	interleukin 1 beta	Homo sapiens	29-37
12819195-4	2003	Here, we show that acute exposure of THP-1 monocytic leukemia cells to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate mimics several features of monocyte adherence, including rapid induction and stabilization of ARE-containing mRNAs encoding interleukin-1 beta and tumor necrosis factor alpha.	phorbol ester 12-o-tetradecanoylphorbol-13-acetate	75-125	interleukin 1 beta	Homo sapiens	250-300
12660148-9	2003	We clarify an essential role for Ca2+ in ATP-induced IL-1beta secretion and indicate an additional role of P2X7 receptors as enhancers of the secretory apparatus by which IL-1beta is released.	Adenosine Triphosphate	41-44	interleukin 1 beta	Homo sapiens	53-61
14686613-0	2003	Hydrogen peroxide mediates interleukin-1beta-induced AP-1 activation in articular chondrocytes: implications for the regulation of iNOS expression.	Hydrogen Peroxide	0-17	interleukin 1 beta	Homo sapiens	27-44
12626343-1	2003	Peroxynitrite, formed by nitric oxide and superoxide, has been shown to nitrate and reduce the function of proinflammatory proteins such as interleukin (IL)-8, monocyte chemoattractant protein-1, and eotaxin, but in contrast, to enhance the function of the anti-inflammatory cytokine IL-10 in reducing IL-1 release from blood monocytes.	Peroxynitrous Acid	0-13	interleukin 1 beta	Homo sapiens	284-288
12878503-10	2003	Pretreatment of human monocytes with thalidomide prevented the secretion of TNF-alpha and IL-1beta but not that of IL-6.	Thalidomide	37-48	interleukin 1 beta	Homo sapiens	90-98
12880609-0	2003	Modulating effect of glutamine on IL-1beta-induced cytokine production by human gut.	Glutamine	21-30	interleukin 1 beta	Homo sapiens	34-42
12689943-0	2003	Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	19-36
12689943-5	2003	Resveratrol significantly reduced production of IL-1beta in OCIM2 cells.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	48-56
14686613-8	2003	These results indicate that H2O2 is a major mediator of IL-1-induced AP-1 activation in articular chondrocytes and that inhibition of ROS production is an effective strategy to block this IL-1-induced response.	Hydrogen Peroxide	28-32	interleukin 1 beta	Homo sapiens	56-60
14686613-8	2003	These results indicate that H2O2 is a major mediator of IL-1-induced AP-1 activation in articular chondrocytes and that inhibition of ROS production is an effective strategy to block this IL-1-induced response.	Hydrogen Peroxide	28-32	interleukin 1 beta	Homo sapiens	188-192
14686613-8	2003	These results indicate that H2O2 is a major mediator of IL-1-induced AP-1 activation in articular chondrocytes and that inhibition of ROS production is an effective strategy to block this IL-1-induced response.	Reactive Oxygen Species	134-137	interleukin 1 beta	Homo sapiens	188-192
12880609-3	2003	The aim of this work was to evaluate the effects of glutamine on IL-1beta-induced cytokine production by human gut.	Glutamine	52-61	interleukin 1 beta	Homo sapiens	65-73
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Reactive Oxygen Species	97-120	interleukin 1 beta	Homo sapiens	30-47
12880609-4	2003	METHODS: Duodenal biopsies from healthy volunteers were stimulated in vitro by IL-1beta in the presence of increasing glutamine concentrations.	Glutamine	118-127	interleukin 1 beta	Homo sapiens	79-87
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Reactive Oxygen Species	97-120	interleukin 1 beta	Homo sapiens	49-53
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Reactive Oxygen Species	97-120	interleukin 1 beta	Homo sapiens	183-187
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Reactive Oxygen Species	122-125	interleukin 1 beta	Homo sapiens	30-47
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Reactive Oxygen Species	122-125	interleukin 1 beta	Homo sapiens	49-53
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Reactive Oxygen Species	122-125	interleukin 1 beta	Homo sapiens	183-187
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Hydrogen Peroxide	138-155	interleukin 1 beta	Homo sapiens	30-47
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Hydrogen Peroxide	138-155	interleukin 1 beta	Homo sapiens	49-53
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Hydrogen Peroxide	138-155	interleukin 1 beta	Homo sapiens	183-187
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Hydrogen Peroxide	157-161	interleukin 1 beta	Homo sapiens	30-47
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Hydrogen Peroxide	157-161	interleukin 1 beta	Homo sapiens	49-53
14686613-1	2003	The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses.	Hydrogen Peroxide	157-161	interleukin 1 beta	Homo sapiens	183-187
14686613-2	2003	This study aimed at elucidating the role of ROS, particularly H2O2, in mediating IL-1-induced activation of the transcription factor activator protein-1 (AP-1) in primary cultures of articular chondrocytes.	Reactive Oxygen Species	44-47	interleukin 1 beta	Homo sapiens	81-85
14686613-2	2003	This study aimed at elucidating the role of ROS, particularly H2O2, in mediating IL-1-induced activation of the transcription factor activator protein-1 (AP-1) in primary cultures of articular chondrocytes.	Hydrogen Peroxide	62-66	interleukin 1 beta	Homo sapiens	81-85
14686613-5	2003	The results of electrophoretic mobility shift assays showed that both IL-1 and H2O2 activated AP-1 and that inhibition of IL-1-induced ROS production abrogated AP-1 activation.	Reactive Oxygen Species	135-138	interleukin 1 beta	Homo sapiens	122-126
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Calcium	82-89	interleukin 1 beta	Homo sapiens	153-175
12952251-0	2003	Modulation by cAMP of IL-1beta-induced eotaxin and MCP-1 expression and release in human airway smooth muscle cells.	Cyclic AMP	14-18	interleukin 1 beta	Homo sapiens	22-30
12952251-5	2003	Forskolin, a direct stimulator of adenylyl cyclase, decreased the interleukin (IL)-1beta-induced eotaxin and MCP-1 release by 73+/-8 and 65+/-6%, respectively.	Colforsin	0-9	interleukin 1 beta	Homo sapiens	66-88
12952251-7	2003	Prostaglandin E2, known as an activator of the prostanoid receptors EP2 and EP4, which are positively coupled to adenylyl cyclase, also decreased the IL-1beta-induced eotaxin and MCP-1 production by 57+/-17 and 53+/-4%, respectively.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	150-158
12952251-10	2003	This study shows that an increase in intracellular cyclic adenosine monophosphate concentration may decrease the interleukin-1beta-induced eotaxin and monocyte chemotactic protein-1 expression and production.	Cyclic AMP	51-81	interleukin 1 beta	Homo sapiens	113-130
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Calcimycin	100-106	interleukin 1 beta	Homo sapiens	153-175
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	bamboo salt	0-18	interleukin 1 beta	Homo sapiens	153-175
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Tetradecanoylphorbol Acetate	39-70	interleukin 1 beta	Homo sapiens	153-175
12880581-10	2003	The expression of TIMP-1 was significantly increased by DHEA at concentrations exceeding 10 micro M. The effects of DHEA on the gene expressions of MMP-1 and -3 were more prominent in the presence of IL-1beta, in which DHEA suppressed not only MMP-1, but also MMP-3 at the lower concentrations, 10 and 50 micro M, respectively.	Dehydroepiandrosterone	56-60	interleukin 1 beta	Homo sapiens	200-208
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Tetradecanoylphorbol Acetate	72-75	interleukin 1 beta	Homo sapiens	153-175
12880581-10	2003	The expression of TIMP-1 was significantly increased by DHEA at concentrations exceeding 10 micro M. The effects of DHEA on the gene expressions of MMP-1 and -3 were more prominent in the presence of IL-1beta, in which DHEA suppressed not only MMP-1, but also MMP-3 at the lower concentrations, 10 and 50 micro M, respectively.	Dehydroepiandrosterone	116-120	interleukin 1 beta	Homo sapiens	200-208
12880581-10	2003	The expression of TIMP-1 was significantly increased by DHEA at concentrations exceeding 10 micro M. The effects of DHEA on the gene expressions of MMP-1 and -3 were more prominent in the presence of IL-1beta, in which DHEA suppressed not only MMP-1, but also MMP-3 at the lower concentrations, 10 and 50 micro M, respectively.	Dehydroepiandrosterone	116-120	interleukin 1 beta	Homo sapiens	200-208
12871602-10	2003	Stimulation with LPS revealed that mevastatin-treated monocytes retained the high IL-1beta output characteristic of undifferentiated cells; conversely, IL-1Ra release was inhibited.	mevastatin	35-45	interleukin 1 beta	Homo sapiens	82-90
12738769-7	2003	We present evidence suggesting that interleukin (IL)-1beta plays a significant role in mediating the effects of Abeta(1-40) because Abeta(1-40) increased hippocampal IL-1beta and because several effects of Abeta(1-40) were inhibited by the caspase-1 inhibitor Ac-YVAD-CMK.	ac-yvad	260-267	interleukin 1 beta	Homo sapiens	36-58
12738769-8	2003	On the basis of our findings, we propose that Abeta-induced changes in hippocampal plasticity are likely to be dependent upon IL-1beta-triggered activation of JNK.	UNII-042A8N37WH	46-51	interleukin 1 beta	Homo sapiens	126-134
14669830-2	2003	In addition, intravenous or oral pulse calcitriol treatment suppresses interleukin 6 (IL6) and interleukin1beta (IL1beta) in hemodialysis patients.	Calcitriol	39-49	interleukin 1 beta	Homo sapiens	95-111
14669830-2	2003	In addition, intravenous or oral pulse calcitriol treatment suppresses interleukin 6 (IL6) and interleukin1beta (IL1beta) in hemodialysis patients.	Calcitriol	39-49	interleukin 1 beta	Homo sapiens	113-120
12871602-11	2003	Concurrent treatment with mevalonolactone prevented the induction of apoptosis and suppressed both IL-1beta and IL-1Ra release in response to LPS, suggesting a rate-limiting role for HMG-CoA reductase in monocyte differentiation.	mevalonolactone	26-41	interleukin 1 beta	Homo sapiens	99-107
12860389-1	2003	Prostaglandin (PG) E2 release is induced in pulmonary A549 cells by the NF-kappaB-activating stimuli interleukin-1beta (IL-1beta) and phorbol 12-myristate 13-acetate (PMA).	Dinoprostone	0-21	interleukin 1 beta	Homo sapiens	120-128
12672669-5	2003	In LSF cells, IL-1beta significantly increased IL-8 and PGE2 synthesis and COX-2 and IL-8 mRNA expression, but progesterone significantly attenuated these effects.	Dinoprostone	56-60	interleukin 1 beta	Homo sapiens	14-22
12860389-3	2003	IkappaBalphaDeltaN repressed IL-1beta-induced, but not PMA-induced, cycloxygenase-2 (COX-2) and microsomal prostaglandin E synthase (mPGES) expression.	ikappabalphadeltan	0-18	interleukin 1 beta	Homo sapiens	29-37
12860389-4	2003	These data conclusively demonstrate a substantial role for NF-kappaB in the co-ordinate induction of COX-2, mPGES and in the corresponding release of PGE2 by IL-1beta.	Dinoprostone	150-154	interleukin 1 beta	Homo sapiens	158-166
12719420-3	2003	Employing this approach, biglycan expression turned out to be down-regulated time- and dose-dependently either by interleukin-1beta-stimulated endogenous nitric oxide production or by direct application of the exogenous nitric oxide donor, diethylenetriamine nitric oxide.	Nitric Oxide	154-166	interleukin 1 beta	Homo sapiens	114-131
12818355-4	2003	We observed that this natural compound and its active principle, caffeic acid phenethyl ester (CAPE), were able to contrast the harmful effects of IL-1beta.	caffeic acid phenethyl ester	65-93	interleukin 1 beta	Homo sapiens	147-155
12818355-4	2003	We observed that this natural compound and its active principle, caffeic acid phenethyl ester (CAPE), were able to contrast the harmful effects of IL-1beta.	caffeic acid phenethyl ester	95-99	interleukin 1 beta	Homo sapiens	147-155
12818365-8	2003	While the ARE-specific inducer tBHQ did not modulate the basal expression of MGST1-L1, it was found to act as an antagonist of interleukin-1 beta-stimulated MGST1-L1 overexpression.	2-tert-butylhydroquinone	31-35	interleukin 1 beta	Homo sapiens	127-145
12860389-0	2003	IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	0-8
12860389-1	2003	Prostaglandin (PG) E2 release is induced in pulmonary A549 cells by the NF-kappaB-activating stimuli interleukin-1beta (IL-1beta) and phorbol 12-myristate 13-acetate (PMA).	Dinoprostone	0-21	interleukin 1 beta	Homo sapiens	101-118
12921636-13	2003	The expression of alpha-SMA was down-regulated by 40% in the SB203580 group in comparison with that in the control (P &lt; 0.01) and by 50% in comparison with that in the IL-1beta group (P &lt; 0.001).	alpha-sma	18-27	interleukin 1 beta	Homo sapiens	171-179
12921636-19	2003	SB203580 uppercased the IL-1beta-induced expression of alpha-SMA and the enhancement of cell migration ability were suppressed by 51% (P &lt; 0.05).	SB 203580	0-8	interleukin 1 beta	Homo sapiens	24-32
12672669-7	2003	In postlabor amnion cells, IL-1beta increased IL-8 and PGE2 synthesis and COX-2 expression, but progesterone did not attenuate the effect of IL-1beta upon IL-8 synthesis.	Dinoprostone	55-59	interleukin 1 beta	Homo sapiens	27-35
12672669-6	2003	In prelabor amnion cells, IL-1beta also increased IL-8 and PGE2 synthesis and both COX-2 and IL-8 mRNA and promoter expression; however, progesterone significantly attenuated these effects on IL-8 and PGE2 synthesis and COX-2 expression.	Dinoprostone	59-63	interleukin 1 beta	Homo sapiens	26-34
12672669-6	2003	In prelabor amnion cells, IL-1beta also increased IL-8 and PGE2 synthesis and both COX-2 and IL-8 mRNA and promoter expression; however, progesterone significantly attenuated these effects on IL-8 and PGE2 synthesis and COX-2 expression.	Dinoprostone	201-205	interleukin 1 beta	Homo sapiens	26-34
12871843-5	2003	We examined the role of the mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK) in TNFalpha- and IL-1beta-induced GM-CSF, RANTES and IL-8 production in HASMC by using a novel specific inhibitor for JNK (SP600125).	pyrazolanthrone	221-229	interleukin 1 beta	Homo sapiens	115-123
12871843-12	2003	Maximum TNFalpha- or IL-1beta-induced phosphorylation of JNK in HASMC occurred after 15 min and returned to baseline levels after 4 h. SP600125 inhibited TNFalpha- and IL-1beta-induced JNK activity in HASMC as shown by the reduced phosphorylation of its substrate c-jun.	pyrazolanthrone	135-143	interleukin 1 beta	Homo sapiens	21-29
12871843-13	2003	Furthermore, GM-CSF, RANTES and to a lesser extent IL-8 release from HASMC treated with TNFalpha and IL-1beta was inhibited dosedependently by SP600125.	pyrazolanthrone	143-151	interleukin 1 beta	Homo sapiens	101-109
12871843-12	2003	Maximum TNFalpha- or IL-1beta-induced phosphorylation of JNK in HASMC occurred after 15 min and returned to baseline levels after 4 h. SP600125 inhibited TNFalpha- and IL-1beta-induced JNK activity in HASMC as shown by the reduced phosphorylation of its substrate c-jun.	pyrazolanthrone	135-143	interleukin 1 beta	Homo sapiens	168-176
12871843-13	2003	Furthermore, GM-CSF, RANTES and to a lesser extent IL-8 release from HASMC treated with TNFalpha and IL-1beta was inhibited dosedependently by SP600125.	hasmc	69-74	interleukin 1 beta	Homo sapiens	101-109
12839952-7	2003	In contrast, Wortmannin, a phosphoinositide 3-kinase inhibitor upstream of protein kinase B/Akt, led to a slight increase in COX-2 mRNA expression after IL-1 beta treatment.	Wortmannin	13-23	interleukin 1 beta	Homo sapiens	153-162
12885386-7	2003	Treatment with alendronate increased LPS-induced secretion of IL-1beta, IL-6 and TNF-alpha from RAW 264 macrophages 2.4-, 1.4- and 1.8-fold, respectively.	Alendronate	15-26	interleukin 1 beta	Homo sapiens	62-70
12901854-6	2003	Serum IL-1beta concentrations (pg/mL) were significantly higher in the USAP group (21.8 +/- 3.4) compared to the SAP group (5.0 +/- 0.1) and the PMI group (5.4 +/- 1.6).	pmi	145-148	interleukin 1 beta	Homo sapiens	6-14
14656685-0	2003	Ex vivo lipopolysaccharide (LPS)-induced TNF-alpha, IL-1beta, IL-6 and PGE2 secretion in whole blood from Type 1 diabetes mellitus patients with or without aggressive periodontitis.	ex vivo lipopolysaccharide	0-26	interleukin 1 beta	Homo sapiens	52-60
12882449-2	2003	Therefore the current study investigated whether N-acetylcysteine (NAC), an antioxidative agent, inhibits the interleukin (IL)-1beta-induced expression and production of eotaxin and monocyte chemotactic protein (MCP)-1 in human airway smooth muscle cells (HASMC).	Acetylcysteine	49-65	interleukin 1 beta	Homo sapiens	110-132
12882449-2	2003	Therefore the current study investigated whether N-acetylcysteine (NAC), an antioxidative agent, inhibits the interleukin (IL)-1beta-induced expression and production of eotaxin and monocyte chemotactic protein (MCP)-1 in human airway smooth muscle cells (HASMC).	Acetylcysteine	67-70	interleukin 1 beta	Homo sapiens	110-132
12882449-4	2003	NAC (1 mM) also decreased the IL-1beta-induced activation of p38 MAPK.	Acetylcysteine	0-3	interleukin 1 beta	Homo sapiens	30-38
12882449-5	2003	Compared with unstimulated cells, a four-fold increase in 8-isoprostane production in IL-1beta-stimulated HASMC was observed, which could be inhibited by NAC in a concentration-dependent way, with a maximum inhibition of 39 +/- 12%, with 1 mM NAC.	8-epi-prostaglandin F2alpha	58-71	interleukin 1 beta	Homo sapiens	86-94
12882449-5	2003	Compared with unstimulated cells, a four-fold increase in 8-isoprostane production in IL-1beta-stimulated HASMC was observed, which could be inhibited by NAC in a concentration-dependent way, with a maximum inhibition of 39 +/- 12%, with 1 mM NAC.	hasmc	106-111	interleukin 1 beta	Homo sapiens	86-94
12882449-5	2003	Compared with unstimulated cells, a four-fold increase in 8-isoprostane production in IL-1beta-stimulated HASMC was observed, which could be inhibited by NAC in a concentration-dependent way, with a maximum inhibition of 39 +/- 12%, with 1 mM NAC.	Acetylcysteine	154-157	interleukin 1 beta	Homo sapiens	86-94
12882449-5	2003	Compared with unstimulated cells, a four-fold increase in 8-isoprostane production in IL-1beta-stimulated HASMC was observed, which could be inhibited by NAC in a concentration-dependent way, with a maximum inhibition of 39 +/- 12%, with 1 mM NAC.	Acetylcysteine	243-246	interleukin 1 beta	Homo sapiens	86-94
12882449-6	2003	The present study demonstrated that N-acetylcysteine inhibits the interleukin-1beta-induced eotaxin and monocyte chemotactic protein 1 expression and production due to a decreased activation of p38 mitogen-activated protein kinase.	Acetylcysteine	36-52	interleukin 1 beta	Homo sapiens	66-83
12882449-7	2003	This study has also shown that N-acetylcysteine decreases the interleukin-1beta-induced production of reactive oxygen species, as suggested by a reduction in the 8-isoprostane production.	Acetylcysteine	31-47	interleukin 1 beta	Homo sapiens	62-79
12882449-7	2003	This study has also shown that N-acetylcysteine decreases the interleukin-1beta-induced production of reactive oxygen species, as suggested by a reduction in the 8-isoprostane production.	Reactive Oxygen Species	102-125	interleukin 1 beta	Homo sapiens	62-79
12882449-7	2003	This study has also shown that N-acetylcysteine decreases the interleukin-1beta-induced production of reactive oxygen species, as suggested by a reduction in the 8-isoprostane production.	8-epi-prostaglandin F2alpha	162-175	interleukin 1 beta	Homo sapiens	62-79
12824233-1	2003	PURPOSE: This study investigated the regulated expression of collagenases (MMP-1, -8, and -13) and stromelysins (MMP-3, -10, and -11) by human corneal epithelial cells treated with IL-1 beta, TNF-alpha, and doxycycline, a medication used to treat ocular surface diseases.	Doxycycline	207-218	interleukin 1 beta	Homo sapiens	181-190
12774247-5	2003	In contrast, ASA aggravated significantly WRS-induced lesions, and this was accompanied by a fall in the GBF, suppression of prostaglandin E(2) generation, and significant rise in ROS chemiluminescence and in plasma TNFalpha and IL-1beta levels.	Aspirin	13-16	interleukin 1 beta	Homo sapiens	229-237
12921647-7	2003	DEX 0.1 mmol/L inhibited the spontaneous release of TNF-alpha, sTNFR-2, IL-1beta and IL-10 (P &lt; 0.001 or &lt; 0.05 or &lt;0.01).	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	72-80
12854631-4	2003	Using Western blot, we observed an activation of p38 MAPK, JNK kinase and p42/p44 ERK when HASMC were stimulated with IL-1beta.	hasmc	91-96	interleukin 1 beta	Homo sapiens	118-126
12860295-5	2003	We also demonstrated that the adhesion of tumor cells to IL-1beta-treated HUVEC was inhibited by gold compounds such as aurothioglucose and aurothiomalate.	Aurothioglucose	120-135	interleukin 1 beta	Homo sapiens	57-65
12921647-9	2003	Similar to POF, DEX (0.1 mmol/L) inhibited the production of these LPS-stimulated cytokines (P &lt; 0.05 or &lt; 0.001), but not of sTNFR-1 and IL-1beta.	Dexamethasone	16-19	interleukin 1 beta	Homo sapiens	144-152
12890453-8	2003	Our data could lend support to the hypothesis that IL-1beta is mainly involved in the functional alterations of cardiomyocytes under conditions marked by mononuclear cell infiltration and by downregulation of calcium.	Calcium	209-216	interleukin 1 beta	Homo sapiens	51-59
12637577-2	2003	Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha (SBR-p38alpha) that fails to bind to SB 203580.	SB 203580	205-214	interleukin 1 beta	Homo sapiens	50-72
12637577-2	2003	Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha (SBR-p38alpha) that fails to bind to SB 203580.	Antimony	205-207	interleukin 1 beta	Homo sapiens	50-72
12637577-2	2003	Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha (SBR-p38alpha) that fails to bind to SB 203580.	Antimony	249-251	interleukin 1 beta	Homo sapiens	50-72
12623793-5	2003	Treatment of HLMVEC with 5 ng/ml interleukin-1beta and 200 U/ml interferon-gamma for 16 h upregulated B(1) receptors as shown by an approximately fourfold increase in prolonged (&gt;20 min) output of NO in response to des-Arg(10)-kallidin, which was blocked by the B(1) antagonist des-Arg(10)-Leu(9)-kallidin.	des-arg	218-225	interleukin 1 beta	Homo sapiens	33-50
12623793-5	2003	Treatment of HLMVEC with 5 ng/ml interleukin-1beta and 200 U/ml interferon-gamma for 16 h upregulated B(1) receptors as shown by an approximately fourfold increase in prolonged (&gt;20 min) output of NO in response to des-Arg(10)-kallidin, which was blocked by the B(1) antagonist des-Arg(10)-Leu(9)-kallidin.	des-arg	281-288	interleukin 1 beta	Homo sapiens	33-50
12623793-5	2003	Treatment of HLMVEC with 5 ng/ml interleukin-1beta and 200 U/ml interferon-gamma for 16 h upregulated B(1) receptors as shown by an approximately fourfold increase in prolonged (&gt;20 min) output of NO in response to des-Arg(10)-kallidin, which was blocked by the B(1) antagonist des-Arg(10)-Leu(9)-kallidin.	Leucine	293-296	interleukin 1 beta	Homo sapiens	33-50
12794822-7	2003	Upon stimulation with IL-1beta, elevation of COX-2, but not COX-1, mRNA and protein preceded the enhancement of PGE(2) synthesis.	Dinoprostone	112-118	interleukin 1 beta	Homo sapiens	22-30
12773708-2	2003	Treatment of human peripheral blood mononuclear cells (PBMCs) with PG101 increased levels of TNF-alpha, IL-1beta, IL-10, and IL-12 by 100- to 1000-fold, whereas GM-CSF and IL-18 were activated by an order of magnitude.	pg101	67-72	interleukin 1 beta	Homo sapiens	104-112
12794822-8	2003	In the presence of 300-400 microM Tau-Cl, significant inhibition of IL-1beta-triggered COX-2 mRNA and protein, and a related decrease in PGE(2) production, was observed.	N-chlorotaurine	34-40	interleukin 1 beta	Homo sapiens	68-76
12794822-10	2003	CONCLUSION: Tau-Cl inhibits IL-1beta-triggered elevation of COX-2 and generation of PGE(2) by RA FLS.	N-chlorotaurine	12-18	interleukin 1 beta	Homo sapiens	28-36
12794822-10	2003	CONCLUSION: Tau-Cl inhibits IL-1beta-triggered elevation of COX-2 and generation of PGE(2) by RA FLS.	Prostaglandins E	84-87	interleukin 1 beta	Homo sapiens	28-36
12813001-11	2003	4 Cannabinoids inhibited secretion of IL-1beta and tumor necrosis factor-alpha (TNF-alpha) by stimulated THP-1 cells, but these effects could not be directly correlated with their antineurotoxic activity.	Cannabinoids	2-14	interleukin 1 beta	Homo sapiens	38-46
12797482-10	2003	Endothelial cell pretreatment with IL-4 or IL-1beta further increased leukotriene C4 release (1,789.1 and 2,895.1 pg x mL(-1), respectively), whereas pretreatment with IFN-gamma decreased it (293.7 pg x mL(-1)).	Leukotriene C4	70-84	interleukin 1 beta	Homo sapiens	43-51
12773708-5	2003	From the human PBMCs treated with PG101, TNF-alpha was a first cytokine to be activated, detectable at 2 hr post-treatment followed by IL-1beta at 6 hr post-treatment.	pg101	34-39	interleukin 1 beta	Homo sapiens	135-143
12782016-5	2003	When RA synovial fibroblasts were pretreated with rofecoxib for 16 h and then stimulated with interleukin (IL)-1beta, their CM induced significantly less HMVEC tube formation when compared with CM from vehicle-treated RA synovial fibroblasts.	rofecoxib	50-59	interleukin 1 beta	Homo sapiens	94-116
12730964-10	2003	This mechanism of PGE(2) amplification may be active in brain pathologies where both OSM and IL-1beta are present, such as glioblastomas and multiple sclerosis.	Prostaglandins E	18-21	interleukin 1 beta	Homo sapiens	93-101
12730964-4	2003	More importantly, in combination with the inflammatory mediators IL-1beta, tumor necrosis factor-alpha, and lipopolysaccharide, OSM exhibits a striking synergy, resulting in up to 50-fold higher PGE(2) production by astrocytes, astroglioma, and neuroblastoma cell lines.	Dinoprostone	195-201	interleukin 1 beta	Homo sapiens	65-102
12761889-0	2003	ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	29-37
12730964-5	2003	Enhanced PGE(2) production by OSM and IL-1beta treatment is explained by their effect on cyclooxygenase-2 (COX-2), an enzyme that catalyzes the committed step in PGE(2) synthesis.	Prostaglandins E	9-12	interleukin 1 beta	Homo sapiens	38-46
12730964-5	2003	Enhanced PGE(2) production by OSM and IL-1beta treatment is explained by their effect on cyclooxygenase-2 (COX-2), an enzyme that catalyzes the committed step in PGE(2) synthesis.	Prostaglandins E	162-165	interleukin 1 beta	Homo sapiens	38-46
12730964-6	2003	Of the enzymes involved in PGE(2) biosynthesis, only COX-2 mRNA and protein levels are synergistically amplified by OSM and IL-1beta.	Dinoprostone	27-33	interleukin 1 beta	Homo sapiens	124-132
12730964-9	2003	SB202190 and U0126, inhibitors of p38 MAPK and ERK1/2 activation, respectively, inhibit IL-1beta and OSM upregulation of COX-2 and PGE(2), indicating that these MAPK cascades are utilized by both stimuli.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	0-8	interleukin 1 beta	Homo sapiens	88-96
12730964-9	2003	SB202190 and U0126, inhibitors of p38 MAPK and ERK1/2 activation, respectively, inhibit IL-1beta and OSM upregulation of COX-2 and PGE(2), indicating that these MAPK cascades are utilized by both stimuli.	U 0126	13-18	interleukin 1 beta	Homo sapiens	88-96
12730964-9	2003	SB202190 and U0126, inhibitors of p38 MAPK and ERK1/2 activation, respectively, inhibit IL-1beta and OSM upregulation of COX-2 and PGE(2), indicating that these MAPK cascades are utilized by both stimuli.	Prostaglandins E	131-134	interleukin 1 beta	Homo sapiens	88-96
12769672-8	2003	This technique was used to monitor the transcription patterns of mRNA encoding TNF-alpha, IL-1beta, and Interferon-gamma in human cell lines or primary PBMC treated with inducers such as PMA, ionomycin, and endotoxin.	Tetradecanoylphorbol Acetate	187-190	interleukin 1 beta	Homo sapiens	90-98
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	Oligonucleotides	49-65	interleukin 1 beta	Homo sapiens	150-159
12788874-0	2003	Interleukin-1 beta stimulates progesterone production by in vitro human luteal cells: evidence of a mediatory role of prostaglandins.	Progesterone	30-42	interleukin 1 beta	Homo sapiens	0-18
12788874-0	2003	Interleukin-1 beta stimulates progesterone production by in vitro human luteal cells: evidence of a mediatory role of prostaglandins.	Prostaglandins	118-132	interleukin 1 beta	Homo sapiens	0-18
12788874-1	2003	We have investigated whether IL-1 beta, a cytokine with an important role in ovarian physiology, is also involved in progesterone (P) synthesis in human luteal cells, and whether this effect is mediated via the cyclooxygenase (COX) pathway.	Progesterone	117-129	interleukin 1 beta	Homo sapiens	29-38
12788874-3	2003	We observed a significant increase in prostaglandin (PG)release after IL-1 beta treatment; the cytokine was more effective on PGE(2) than PGF(2 alpha) release.	Prostaglandins	38-51	interleukin 1 beta	Homo sapiens	70-79
12788874-3	2003	We observed a significant increase in prostaglandin (PG)release after IL-1 beta treatment; the cytokine was more effective on PGE(2) than PGF(2 alpha) release.	Prostaglandins	53-55	interleukin 1 beta	Homo sapiens	70-79
12788874-3	2003	We observed a significant increase in prostaglandin (PG)release after IL-1 beta treatment; the cytokine was more effective on PGE(2) than PGF(2 alpha) release.	Prostaglandins E	126-129	interleukin 1 beta	Homo sapiens	70-79
12626640-8	2003	Together, our results for the first time demonstrate that PBN suppresses the IL-1 beta-stimulated expression of MMP-13 in OA chondrocytes and that this was achieved by inhibiting the activation of JNK and AP-1.	phenyl-N-tert-butylnitrone	58-61	interleukin 1 beta	Homo sapiens	77-86
12730540-10	2003	CONCLUSIONS: Based on these results we hypothesize that IL-1beta produced by activated monocytes/macrophages increases the production of hydrogen peroxide by chondrocytes.	Hydrogen Peroxide	137-154	interleukin 1 beta	Homo sapiens	56-64
12788874-3	2003	We observed a significant increase in prostaglandin (PG)release after IL-1 beta treatment; the cytokine was more effective on PGE(2) than PGF(2 alpha) release.	Prostaglandins F	138-141	interleukin 1 beta	Homo sapiens	70-79
12788874-5	2003	Treatment with the human IL-1 receptor antagonist was associated with a decrease in both basal and IL-1 beta-stimulated PG production.	Prostaglandins	120-122	interleukin 1 beta	Homo sapiens	99-108
12788874-6	2003	Moreover, IL-1 beta induced a concentration-dependent increase in P production and release, an effect counteracted by the COX inhibitor indomethacin.	Indomethacin	136-148	interleukin 1 beta	Homo sapiens	10-19
12626640-3	2003	Phenyl N-tert-butylnitrone (PBN), a spin trap agent, inhibited the IL-1 beta-induced expression of MMP-13 in human osteoarthritis (OA) chondrocytes.	phenyl-N-tert-butylnitrone	0-26	interleukin 1 beta	Homo sapiens	67-76
12626640-3	2003	Phenyl N-tert-butylnitrone (PBN), a spin trap agent, inhibited the IL-1 beta-induced expression of MMP-13 in human osteoarthritis (OA) chondrocytes.	phenyl-N-tert-butylnitrone	28-31	interleukin 1 beta	Homo sapiens	67-76
12700687-5	2003	However, MDD patients who were homozygous for the -511T allele of the IL-1beta gene had a trend of less severity of depressive symptoms and more favorable fluoxetine therapeutic response than -511C carriers.	Fluoxetine	155-165	interleukin 1 beta	Homo sapiens	70-78
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	Dexamethasone	286-299	interleukin 1 beta	Homo sapiens	150-159
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	Dexamethasone	286-299	interleukin 1 beta	Homo sapiens	221-230
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	lpmc	312-316	interleukin 1 beta	Homo sapiens	150-159
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	lpmc	312-316	interleukin 1 beta	Homo sapiens	221-230
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	Oligonucleotides	49-65	interleukin 1 beta	Homo sapiens	221-230
12624100-6	2003	Moreover, labeling of this polypeptide correlated with irreversible inhibition of ATP-induced IL-1beta posttranslational processing.	Adenosine Triphosphate	82-85	interleukin 1 beta	Homo sapiens	94-102
12782181-3	2003	Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression.	Nitrites	150-157	interleukin 1 beta	Homo sapiens	77-95
12802209-0	2003	Triptolide inhibits TNF-alpha, IL-1 beta and NO production in primary microglial cultures.	triptolide	0-10	interleukin 1 beta	Homo sapiens	31-40
12802209-4	2003	Pretreatment with triptolide was able to dose-dependently reduce the lipopolysaccharide (LPS)-induced nitrite accumulation and tumor necrosis factor-alpha and interleukin-1beta release from LPS-activated microglia as revealed by Griess reaction and ELISA, respectively.	triptolide	18-28	interleukin 1 beta	Homo sapiens	159-176
12732207-6	2003	The IL-1beta-induced upregulation of nephrin expression occurs independently of nitric oxide (NO) generation, since the NO-synthase inhibitor N(G)-monomethyl-L-arginine does not block the IL-1beta effect.	Nitric Oxide	80-92	interleukin 1 beta	Homo sapiens	4-12
12732207-6	2003	The IL-1beta-induced upregulation of nephrin expression occurs independently of nitric oxide (NO) generation, since the NO-synthase inhibitor N(G)-monomethyl-L-arginine does not block the IL-1beta effect.	omega-N-Methylarginine	142-168	interleukin 1 beta	Homo sapiens	4-12
12732207-9	2003	The only inhibitor that was able to block IL-1beta- and TNFalpha-induced nephrin upregulation was rottlerin, which has been suggested to act as a selective PKCdelta inhibitor.	rottlerin	98-107	interleukin 1 beta	Homo sapiens	42-50
12618429-10	2003	IL-1beta rapidly increased tyrosine phosphorylation of IL-1 type I receptor-associated proteins, suggesting that oxidants may operate through inactivation of local protein-tyrosine phosphatases in the proximal IL-1beta signaling pathway leading to RelA activation.	Tyrosine	27-35	interleukin 1 beta	Homo sapiens	0-8
12726991-9	2003	Moreover, IL-1beta stimulates PA, pro-PA activated by trypsin, and plasmin activity in medium, whereas in cell extract it stimulates pro-PA activated by trypsin and plasmin activity.	pro-pa	34-40	interleukin 1 beta	Homo sapiens	10-18
12726991-9	2003	Moreover, IL-1beta stimulates PA, pro-PA activated by trypsin, and plasmin activity in medium, whereas in cell extract it stimulates pro-PA activated by trypsin and plasmin activity.	pro-pa	133-139	interleukin 1 beta	Homo sapiens	10-18
12730992-0	2003	Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity.	Glutamic Acid	57-66	interleukin 1 beta	Homo sapiens	0-17
12730992-2	2003	Because there is microglia activation in all stages of multiple sclerosis, we determined whether a microglia product, interleukin-1beta, could provide the mechanism for glutamate excitotoxicity.	Glutamic Acid	169-178	interleukin 1 beta	Homo sapiens	118-135
12695157-0	2003	Active leflunomide metabolite inhibits interleukin 1beta, tumour necrosis factor alpha, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures.	Leflunomide	7-18	interleukin 1 beta	Homo sapiens	39-86
12695157-4	2003	OBJECTIVES: Evaluation of the leflunomide active metabolite A771726 (LEF) effect on interleukin 1beta (IL1beta), tumour necrosis factor (TNFalpha), nitric oxide (NO), and stromelysin (metalloproteinase-3 (MMP-3)) production by activated human synovial tissue in culture.	Leflunomide	30-41	interleukin 1 beta	Homo sapiens	84-101
12695157-4	2003	OBJECTIVES: Evaluation of the leflunomide active metabolite A771726 (LEF) effect on interleukin 1beta (IL1beta), tumour necrosis factor (TNFalpha), nitric oxide (NO), and stromelysin (metalloproteinase-3 (MMP-3)) production by activated human synovial tissue in culture.	Leflunomide	30-41	interleukin 1 beta	Homo sapiens	103-110
12695157-12	2003	CONCLUSION: Leflunomide may modulate the rheumatoid articular process by inhibition of local production of IL1beta, TNFalpha, NO, and MMP-3.	Leflunomide	12-23	interleukin 1 beta	Homo sapiens	107-114
12730992-4	2003	This requirement for a mixed glia environment suggests that interleukin-1beta impairs the well-described glutamate-buffering capacity of astrocytes.	Glutamic Acid	105-114	interleukin 1 beta	Homo sapiens	60-77
12730992-5	2003	In support, antagonists at AMPA/kainate glutamate receptors, NBQX and CNQX, blocked the interleukin-1beta toxicity to oligodendrocytes.	6-Cyano-7-nitroquinoxaline-2,3-dione	70-74	interleukin 1 beta	Homo sapiens	88-105
12606352-0	2003	Interleukin-1beta induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle.	Calcium	26-33	interleukin 1 beta	Homo sapiens	0-17
12606352-0	2003	Interleukin-1beta induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle.	Calcium	83-90	interleukin 1 beta	Homo sapiens	0-17
12606352-2	2003	Proinflammatory cytokines have been implicated in the cascade of events leading to preterm and term labor, and we hypothesize that interleukin (IL)-1beta may induce changes in key calcium homeostatic mechanisms and, in turn, augment myometrial contractility before labor.	Calcium	180-187	interleukin 1 beta	Homo sapiens	131-153
12606352-9	2003	HMSM cell excitability was enhanced, as evidenced by increased basal calcium entry and the initiation of spontaneous calcium transients in 37% of IL-1beta-treated cells.	Calcium	117-124	interleukin 1 beta	Homo sapiens	146-154
12606352-10	2003	IL-1beta modulation of calcium mobilization may be an important mechanism in the cascade of events preparing the pregnant uterus for labor.	Calcium	23-30	interleukin 1 beta	Homo sapiens	0-8
12730857-9	2003	Y-27632 inhibited production of tumor necrosis factor-alpha and interleukin-1 beta by lamina propria and peripheral blood mononuclear cells.	Y 27632	0-7	interleukin 1 beta	Homo sapiens	64-82
12825860-0	2003	Phosphocitrate inhibits calcium hydroxyapatite induced mitogenesis and upregulation of matrix metalloproteinase-1, interleukin-1beta and cyclooxygenase-2 mRNA in human breast cancer cell lines.	phosphocitrate	0-14	interleukin 1 beta	Homo sapiens	115-132
12825860-0	2003	Phosphocitrate inhibits calcium hydroxyapatite induced mitogenesis and upregulation of matrix metalloproteinase-1, interleukin-1beta and cyclooxygenase-2 mRNA in human breast cancer cell lines.	Durapatite	24-46	interleukin 1 beta	Homo sapiens	115-132
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	phosphocitrate	173-187	interleukin 1 beta	Homo sapiens	38-55
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	phosphocitrate	173-187	interleukin 1 beta	Homo sapiens	57-65
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	phosphocitrate	173-187	interleukin 1 beta	Homo sapiens	413-421
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	phosphocitrate	189-191	interleukin 1 beta	Homo sapiens	38-55
12765431-9	2003	DEX treatment did not influence PIIINP levels, but reduced IL-1beta levels and inflammatory cell numbers in BAL fluid.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	59-67
12752101-2	2003	Cytosine to thymine transitions at codons -889 and -511 in the IL-1-alpha and IL-1-beta genes, respectively, and an 86-base pair repeat in the IL-1Ra are believed to influence gene transcription.	Cytosine	0-8	interleukin 1 beta	Homo sapiens	78-87
12752101-2	2003	Cytosine to thymine transitions at codons -889 and -511 in the IL-1-alpha and IL-1-beta genes, respectively, and an 86-base pair repeat in the IL-1Ra are believed to influence gene transcription.	Thymine	12-19	interleukin 1 beta	Homo sapiens	78-87
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	phosphocitrate	189-191	interleukin 1 beta	Homo sapiens	57-65
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	calcium phosphate	229-246	interleukin 1 beta	Homo sapiens	38-55
12825860-10	2003	Furthermore, a HA-induced increase in interleukin-1beta (IL-1beta), a potent inducer of MMP-1 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with phosphocitrate (PC) (a naturally occurring inhibitor of calcium phosphate crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, COX-2, MMP-1 and IL-1beta induction, at the transcriptional level.	calcium phosphate	229-246	interleukin 1 beta	Homo sapiens	57-65
12699415-1	2003	In the present study, we aimed to investigate the effects of testosterone deficiency and gonadotropin therapy on the in vitro production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) by peripheral blood mononuclear cells (PBMCs) from patients with idiopathic hypogonadotropic hypogonadism (IHH) in order to elucidate the modulatory role of androgen in cytokine production.	Testosterone	61-73	interleukin 1 beta	Homo sapiens	185-202
12699415-1	2003	In the present study, we aimed to investigate the effects of testosterone deficiency and gonadotropin therapy on the in vitro production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) by peripheral blood mononuclear cells (PBMCs) from patients with idiopathic hypogonadotropic hypogonadism (IHH) in order to elucidate the modulatory role of androgen in cytokine production.	Testosterone	61-73	interleukin 1 beta	Homo sapiens	204-212
12714616-14	2003	The NFkappaB inhibitors pyrrolidinedithiocarbamate (PDTC; 100 microM), caffeic acid phenethyl ester (CAPE; 90 microM), and MG-132 (25 microM), blocked IL-1beta-stimulated expression of hBD-2.	pyrrolidine dithiocarbamic acid	24-50	interleukin 1 beta	Homo sapiens	151-159
12714616-14	2003	The NFkappaB inhibitors pyrrolidinedithiocarbamate (PDTC; 100 microM), caffeic acid phenethyl ester (CAPE; 90 microM), and MG-132 (25 microM), blocked IL-1beta-stimulated expression of hBD-2.	caffeic acid phenethyl ester	71-99	interleukin 1 beta	Homo sapiens	151-159
12714616-15	2003	The p38 mitogen-activated protein (MAP) kinase inhibitor SB203580 (5 microM) and the c-Jun NH2-terminal kinase (JNK) inhibitor SP600125 (25 microM) partially blocked (by 47% and 59%, respectively) the effect of IL-1beta.	pyrazolanthrone	127-135	interleukin 1 beta	Homo sapiens	211-219
12714616-14	2003	The NFkappaB inhibitors pyrrolidinedithiocarbamate (PDTC; 100 microM), caffeic acid phenethyl ester (CAPE; 90 microM), and MG-132 (25 microM), blocked IL-1beta-stimulated expression of hBD-2.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	123-129	interleukin 1 beta	Homo sapiens	151-159
12714616-17	2003	Genistein (50 microM) and dexamethasone (1 microM) also partially blocked (by 26% and 28%, respectively) the effect of IL-1beta.	Genistein	0-9	interleukin 1 beta	Homo sapiens	119-127
12714616-17	2003	Genistein (50 microM) and dexamethasone (1 microM) also partially blocked (by 26% and 28%, respectively) the effect of IL-1beta.	Dexamethasone	26-39	interleukin 1 beta	Homo sapiens	119-127
12727980-7	2003	Treatment with SB202190, a p38 MAPK inhibitor, also reduced the stimulatory effects of IL-1 beta in nondecidualized ESC.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	15-23	interleukin 1 beta	Homo sapiens	87-96
12727980-9	2003	Treatment with 8-bromo-cAMP reduced IL-1 beta-induced phosphorylation of p38 MAPK in nondecidualized ESC.	8-Bromo Cyclic Adenosine Monophosphate	15-27	interleukin 1 beta	Homo sapiens	36-45
12727980-10	2003	In contrast, treatment with H89, a protein kinase A inhibitor, reversed a reduction in IL-1 beta-induced p38 MAPK phosphorylation in the decidualized cells.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	28-31	interleukin 1 beta	Homo sapiens	87-96
12741430-6	2003	MEASUREMENTS AND MAIN RESULTS: Toxicity of the amphotericin B formulations were assessed by measuring interleukin (IL)-1beta expression in an in vitro model.	Amphotericin B	47-61	interleukin 1 beta	Homo sapiens	102-124
12741430-9	2003	Expression of IL-1beta from Sigma, Pharmacia, and Pharma-Tek formulations was increased approximately 250%, 50%, and 25%, respectively, compared with amphotericin A.	amphotericin A	150-164	interleukin 1 beta	Homo sapiens	14-22
12803505-6	2003	RESULTS: IL-1beta levels increased from 16.6 +/- 2.2 to 64.8 +/- 25.1 pg/mL on CU and 21.5 +/- 3.7 to 103.5 +/- 30.7 pg/mL on PS membrane over the 4-h dialysis session.	cuprammonium cellulose	79-81	interleukin 1 beta	Homo sapiens	9-17
12738360-4	2003	We first demonstrated that this method is adequate to measure the induction of interleukin (IL)-1beta and IL-1 receptor antagonist (IL-1 RA) mRNA upon the addition of bacterial lipopolysaccharide (LPS) to whole blood.	bacterial lipopolysaccharide	167-195	interleukin 1 beta	Homo sapiens	79-101
12803505-6	2003	RESULTS: IL-1beta levels increased from 16.6 +/- 2.2 to 64.8 +/- 25.1 pg/mL on CU and 21.5 +/- 3.7 to 103.5 +/- 30.7 pg/mL on PS membrane over the 4-h dialysis session.	polysulfone P 1700	126-128	interleukin 1 beta	Homo sapiens	9-17
12803505-8	2003	IL-1beta levels increased significantly with PS membrane while TNFalpha rise was significant with both the membranes.	polysulfone P 1700	45-47	interleukin 1 beta	Homo sapiens	0-8
12682256-6	2003	In addition, a mutation of the NF-kappaB site at -200 (pkappaB1 site) completely abolished this IL-1beta- and TNF-alpha-induced hBD-2 promoter activation, whereas NF-kappaB inhibitors (MG-132 and helenalin) strongly suppressed it.	helenalin	196-205	interleukin 1 beta	Homo sapiens	96-104
12676369-5	2003	Pretreatment with dexamethasone dose dependently inhibited leptin-induced IL-1beta expression in the hypothalamus.	Dexamethasone	18-31	interleukin 1 beta	Homo sapiens	74-82
12676369-6	2003	Moreover, dexamethasone inhibited leptin-induced IL-1beta expression in the primary cultured glial cells.	Dexamethasone	10-23	interleukin 1 beta	Homo sapiens	49-57
12706459-2	2003	In the present study, we determined that Caco-2 cells express the kappa-opioid receptor and its activation by trans-(+/-)-3,4-dichloro-N-methyl-N[2-(1-pyrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate (U-50488) leads to decreased interleukin-8 secretion in the presence of interleukin-1beta.	trans-(+/-)-3,4-dichloro-n-methyl-n[2-(1-pyrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate	110-207	interleukin 1 beta	Homo sapiens	280-297
12466152-3	2003	In interleukin-1beta (IL-1beta)-stimulated hepatocytes exposed to superoxide, we demonstrate that hepatocyte nuclear factor-4alpha (HNF-4alpha) acts as an activator of redox-associated hepatocyte iNOS expression at the level of protein, mRNA, and promoter activation.	Superoxides	66-76	interleukin 1 beta	Homo sapiens	3-20
12676356-9	2003	An average 8-fold stimulation of 6-ketoPGF(1alpha) formation was obtained with quiescent IL1-beta-exposed HUVECs pretreated for 18 h with 25 microM 9(Z), 11(Z)-CLA, whereas cells preincubated with the 10(E), 12(Z) isomer enhanced this eicosanoid 3-fold.	Eicosanoids	235-245	interleukin 1 beta	Homo sapiens	89-97
12672232-11	2003	We then tested the activity of the four most potent KN-62 derivatives on ATP-stimulated secretion of IL-1beta from monocyte-derived human macrophages, a key cell type in inflammation and innate immunity.	KN 62	52-57	interleukin 1 beta	Homo sapiens	101-109
12672232-11	2003	We then tested the activity of the four most potent KN-62 derivatives on ATP-stimulated secretion of IL-1beta from monocyte-derived human macrophages, a key cell type in inflammation and innate immunity.	Adenosine Triphosphate	73-76	interleukin 1 beta	Homo sapiens	101-109
12466152-3	2003	In interleukin-1beta (IL-1beta)-stimulated hepatocytes exposed to superoxide, we demonstrate that hepatocyte nuclear factor-4alpha (HNF-4alpha) acts as an activator of redox-associated hepatocyte iNOS expression at the level of protein, mRNA, and promoter activation.	Superoxides	66-76	interleukin 1 beta	Homo sapiens	22-30
12527286-3	2003	The production of interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha were enhanced by all metal ions tested as determined by enzyme-linked immunosorbent assay.	Metals	104-109	interleukin 1 beta	Homo sapiens	18-35
12634239-5	2003	RESULTS: The number of TNFalpha and IL1beta secreting cells was significantly higher in patients with pSS than in controls.	pss	102-105	interleukin 1 beta	Homo sapiens	36-43
12634239-10	2003	CONCLUSION: The increased systemic secretion of IL1beta and TNFalpha in patients with pSS points to a pathogenic impact of these cytokines in this autoimmune disease.	pss	86-89	interleukin 1 beta	Homo sapiens	48-55
12676571-1	2003	Like stressors, interleukin-1beta and tumor necrosis factor-alpha (TNF-alpha) increase hypothalamic-pituitary-adrenal (HPA) activity and monoamine turnover at hypothalamic and extrahypothalamic sites.	monoamine	137-146	interleukin 1 beta	Homo sapiens	16-33
12946102-10	2003	Although constitutive IL-1beta expression was inhibited by a physiological dose of cortisol, cortisol synergistically enhanced LPS-induced IL-1beta expression in carp.	Hydrocortisone	83-91	interleukin 1 beta	Homo sapiens	22-30
12946102-10	2003	Although constitutive IL-1beta expression was inhibited by a physiological dose of cortisol, cortisol synergistically enhanced LPS-induced IL-1beta expression in carp.	Hydrocortisone	93-101	interleukin 1 beta	Homo sapiens	139-147
12957788-5	2003	The effect of IL-1beta on the pump disappeared in the presence of indomethacin, a COX inhibitor.	Indomethacin	66-78	interleukin 1 beta	Homo sapiens	14-22
12957788-7	2003	Curcumin, a JNK/AP-1 inhibitor, partially abolished the effect of IL-1beta on ATPase expression but did not interfere with the effect of PGE2.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	66-74
12957788-8	2003	These results indicate that IL-1beta reduces the expression of ATPase independently of NFkB but, through a major pathway involving p38 and COX-2/PGE2, and another pathway involving JNK/AP1.	Dinoprostone	145-149	interleukin 1 beta	Homo sapiens	28-36
12631663-9	2003	IL-1beta mRNA expression of INF-IBS patients at three months post gastroenteritis was significantly greater than NOR-CON whereas that of INF-CON patients was not significantly different from NOR-CON.	nor-con	113-120	interleukin 1 beta	Homo sapiens	0-8
12697042-7	2003	Similar to IL-6, both constitutive and IL-1beta-inducible IL-11 release were dose-dependently inhibited by cortisol (P&lt;0.01); at variance with IL-6, exogenous IL-11 dose-dependently decreased GR numbers in MG-63 cells (P&lt;0.05), while anti-IL-11 antibody significantly increased GR numbers in both cell lines (P&lt;0.05).	Hydrocortisone	107-115	interleukin 1 beta	Homo sapiens	39-47
12639911-12	2003	EP(1) receptor subtype-selective antagonist, SC-51322, blocked IL-1beta-induced and [IL-1beta + INDO + 17-phenyl trinor PGE(2)]-induced increases in IL-1beta mRNAs.	Indomethacin	96-100	interleukin 1 beta	Homo sapiens	85-93
12639911-13	2003	Taken together, our data demonstrate that FP and EP(1) receptors mediate PGF(2alpha) and PGE(2) induction of progenitor IL-1beta expression.	Prostaglandins E	89-92	interleukin 1 beta	Homo sapiens	120-128
12639911-0	2003	Prostaglandin (PG) FP and EP1 receptors mediate PGF2alpha and PGE2 regulation of interleukin-1beta expression in Leydig cell progenitors.	prostaglandin (pg) fp	0-21	interleukin 1 beta	Homo sapiens	81-98
12639911-0	2003	Prostaglandin (PG) FP and EP1 receptors mediate PGF2alpha and PGE2 regulation of interleukin-1beta expression in Leydig cell progenitors.	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	81-98
12639911-1	2003	Prostaglandins (PG) mediate IL-1beta regulation of several interleukin mRNAs in progenitor Leydig cells.	Prostaglandins	0-14	interleukin 1 beta	Homo sapiens	28-36
12639911-2	2003	PGE(2) and PGF(2alpha) potently reverse indomethacin (INDO; a cyclooxygenase inhibitor) inhibition of IL-1beta autoinduction.	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	102-110
12639911-2	2003	PGE(2) and PGF(2alpha) potently reverse indomethacin (INDO; a cyclooxygenase inhibitor) inhibition of IL-1beta autoinduction.	Prostaglandins F	11-14	interleukin 1 beta	Homo sapiens	102-110
12639911-2	2003	PGE(2) and PGF(2alpha) potently reverse indomethacin (INDO; a cyclooxygenase inhibitor) inhibition of IL-1beta autoinduction.	Indomethacin	40-52	interleukin 1 beta	Homo sapiens	102-110
12639911-2	2003	PGE(2) and PGF(2alpha) potently reverse indomethacin (INDO; a cyclooxygenase inhibitor) inhibition of IL-1beta autoinduction.	Indomethacin	54-58	interleukin 1 beta	Homo sapiens	102-110
12639911-3	2003	IL-1beta increases PGE(2) and PGF(2alpha) production.	Prostaglandins E	19-22	interleukin 1 beta	Homo sapiens	0-8
12639911-3	2003	IL-1beta increases PGE(2) and PGF(2alpha) production.	Prostaglandins F	30-33	interleukin 1 beta	Homo sapiens	0-8
12639911-5	2003	Pharmacological characterization of receptors involved in PGE(2) and PGF(2alpha) regulation of IL-1beta mRNA levels was ascertained using real-time PCR analyses.	Prostaglandins E	58-61	interleukin 1 beta	Homo sapiens	95-103
12639911-5	2003	Pharmacological characterization of receptors involved in PGE(2) and PGF(2alpha) regulation of IL-1beta mRNA levels was ascertained using real-time PCR analyses.	Prostaglandins F	69-72	interleukin 1 beta	Homo sapiens	95-103
12639911-9	2003	A selective FP agonist, cloprostenol (0.1 micro M), and PGF(2alpha) (10 micro M) had similar effects on IL-1beta mRNA levels in progenitors treated with IL-1beta + INDO.	Cloprostenol	24-36	interleukin 1 beta	Homo sapiens	104-112
12639911-11	2003	In contrast, EP(1)/EP(3) agonists (17-phenyl trinor PGE(2) and sulprostone) increased IL-1beta mRNAs in a dose-dependent manner.	17-phenyl trinor pge	35-55	interleukin 1 beta	Homo sapiens	86-94
12639911-11	2003	In contrast, EP(1)/EP(3) agonists (17-phenyl trinor PGE(2) and sulprostone) increased IL-1beta mRNAs in a dose-dependent manner.	sulprostone	63-74	interleukin 1 beta	Homo sapiens	86-94
12639911-12	2003	EP(1) receptor subtype-selective antagonist, SC-51322, blocked IL-1beta-induced and [IL-1beta + INDO + 17-phenyl trinor PGE(2)]-induced increases in IL-1beta mRNAs.	SC-51322	45-53	interleukin 1 beta	Homo sapiens	63-71
12639911-12	2003	EP(1) receptor subtype-selective antagonist, SC-51322, blocked IL-1beta-induced and [IL-1beta + INDO + 17-phenyl trinor PGE(2)]-induced increases in IL-1beta mRNAs.	SC-51322	45-53	interleukin 1 beta	Homo sapiens	85-93
12639911-12	2003	EP(1) receptor subtype-selective antagonist, SC-51322, blocked IL-1beta-induced and [IL-1beta + INDO + 17-phenyl trinor PGE(2)]-induced increases in IL-1beta mRNAs.	SC-51322	45-53	interleukin 1 beta	Homo sapiens	85-93
12639911-12	2003	EP(1) receptor subtype-selective antagonist, SC-51322, blocked IL-1beta-induced and [IL-1beta + INDO + 17-phenyl trinor PGE(2)]-induced increases in IL-1beta mRNAs.	Indomethacin	96-100	interleukin 1 beta	Homo sapiens	85-93
12850133-1	2003	Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are produced by hepatic nonparenchymal cells after systemic injury and have been reported to inhibit ATP synthesis in hepatocytes, which may contribute to hepatic dysfunction in inflammatory states.	Adenosine Triphosphate	155-158	interleukin 1 beta	Homo sapiens	0-17
12667652-2	2003	Onset of the behavioral syndrome was associated with the onset of brain infiltration, as well as mRNA expression of interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) and elevated production of interleukin 1 beta protein and prostaglandin E(2) (PGE(2)).	Prostaglandins E	269-272	interleukin 1 beta	Homo sapiens	218-236
12850133-1	2003	Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are produced by hepatic nonparenchymal cells after systemic injury and have been reported to inhibit ATP synthesis in hepatocytes, which may contribute to hepatic dysfunction in inflammatory states.	Adenosine Triphosphate	155-158	interleukin 1 beta	Homo sapiens	19-27
12850133-3	2003	IL-1beta reduced mitochondrial OUR coupled to ATP synthesis via inhibition of phosphorylation reactions which dissipate the MMP, including ATP synthesis and consumption.	Adenosine Triphosphate	46-49	interleukin 1 beta	Homo sapiens	0-8
12850133-3	2003	IL-1beta reduced mitochondrial OUR coupled to ATP synthesis via inhibition of phosphorylation reactions which dissipate the MMP, including ATP synthesis and consumption.	Adenosine Triphosphate	139-142	interleukin 1 beta	Homo sapiens	0-8
12850133-4	2003	Furthermore, the ATP synthesis rate in cytokine-free and IL-1beta-treated hepatocytes was controlled primarily by phosphorylation reactions, which corresponds to a state where the ATP synthesis rate closely follows the cellular energy demand.	Adenosine Triphosphate	17-20	interleukin 1 beta	Homo sapiens	57-65
12850133-4	2003	Furthermore, the ATP synthesis rate in cytokine-free and IL-1beta-treated hepatocytes was controlled primarily by phosphorylation reactions, which corresponds to a state where the ATP synthesis rate closely follows the cellular energy demand.	Adenosine Triphosphate	180-183	interleukin 1 beta	Homo sapiens	57-65
12720152-2	2003	Although its molecular mechanisms of action have not yet been elucidated, thalidomide and the IMiDs affect a variety of cytokines and inflammatory mediators including tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-1beta, interferon gamma (IFNgamma), IL-6, IL-10, IL-12, and COX-2 and angiogenesis factors such as vascular endothelial growth factor (VEGF) and its receptor.	Thalidomide	74-85	interleukin 1 beta	Homo sapiens	207-229
12727445-4	2003	Using whole-cell and outside-out patch-clamp techniques, we observed that IL-1 beta decreased both inward sodium current amplitudes and outward potassium current amplitudes.	Sodium	106-112	interleukin 1 beta	Homo sapiens	74-83
12727445-4	2003	Using whole-cell and outside-out patch-clamp techniques, we observed that IL-1 beta decreased both inward sodium current amplitudes and outward potassium current amplitudes.	Potassium	144-153	interleukin 1 beta	Homo sapiens	74-83
12681956-0	2003	Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes.	Glucosamine	0-11	interleukin 1 beta	Homo sapiens	21-29
12681956-8	2003	GS also inhibited the release of PGE2 to conditioned media of HOC stimulated with IL-1beta.	Dinoprostone	33-37	interleukin 1 beta	Homo sapiens	82-90
12755375-1	2003	OBJECTIVES: To determine the regulatory effects of reactive oxygen species (ROS) on the expression by human osteoarthritic chondrocytes of interleukin (IL)-1beta, -6 and -8, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene in response to interleukin (IL)-1beta or lipopolysaccharide (LPS).	Reactive Oxygen Species	51-74	interleukin 1 beta	Homo sapiens	139-161
12650676-10	2003	Furthermore, with treatment of DNCB, naive THP-1 cells showed augmented expression of HLA, CD80 and secretion of IL-1 beta.	Dinitrochlorobenzene	31-35	interleukin 1 beta	Homo sapiens	113-122
12663496-6	2003	However, stimulation of COX-2 activity by IL-1 beta resulted in a decrease in cell proliferation and an induction of cytotoxicity by AA as well as by EPA.	Eicosapentaenoic Acid	150-153	interleukin 1 beta	Homo sapiens	42-51
12595494-0	2003	PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway.	Cholesterol	126-137	interleukin 1 beta	Homo sapiens	43-60
12595494-3	2003	IL-1beta was shown to inhibit (3)H-cholesterol efflux from HMC and increase total intracellular cholesterol concentration, probably as a result of reduced expression of the adenosine triphosphate (ATP) binding cassette A1 (ABCA1), a transporter protein involved in apolipoprotein-A1 (apo-A1)-mediated lipid efflux.	Cholesterol	35-46	interleukin 1 beta	Homo sapiens	0-8
12595494-3	2003	IL-1beta was shown to inhibit (3)H-cholesterol efflux from HMC and increase total intracellular cholesterol concentration, probably as a result of reduced expression of the adenosine triphosphate (ATP) binding cassette A1 (ABCA1), a transporter protein involved in apolipoprotein-A1 (apo-A1)-mediated lipid efflux.	Cholesterol	96-107	interleukin 1 beta	Homo sapiens	0-8
12595494-3	2003	IL-1beta was shown to inhibit (3)H-cholesterol efflux from HMC and increase total intracellular cholesterol concentration, probably as a result of reduced expression of the adenosine triphosphate (ATP) binding cassette A1 (ABCA1), a transporter protein involved in apolipoprotein-A1 (apo-A1)-mediated lipid efflux.	Adenosine Triphosphate	173-195	interleukin 1 beta	Homo sapiens	0-8
12595494-3	2003	IL-1beta was shown to inhibit (3)H-cholesterol efflux from HMC and increase total intracellular cholesterol concentration, probably as a result of reduced expression of the adenosine triphosphate (ATP) binding cassette A1 (ABCA1), a transporter protein involved in apolipoprotein-A1 (apo-A1)-mediated lipid efflux.	Adenosine Triphosphate	197-200	interleukin 1 beta	Homo sapiens	0-8
12595494-6	2003	Activation of PPARgamma with the agonist prostaglandin J2 (10 micro M) and of PPARalpha with either bezafibrate (100 micro M) or Wy14643 (100 micro M) both increased LXRalpha and ABCA1 gene expression also and enhanced apoA1-mediated cholesterol efflux from lipid-loaded cells, even in the presence of IL-1beta.	Bezafibrate	100-111	interleukin 1 beta	Homo sapiens	302-310
12595494-6	2003	Activation of PPARgamma with the agonist prostaglandin J2 (10 micro M) and of PPARalpha with either bezafibrate (100 micro M) or Wy14643 (100 micro M) both increased LXRalpha and ABCA1 gene expression also and enhanced apoA1-mediated cholesterol efflux from lipid-loaded cells, even in the presence of IL-1beta.	pirinixic acid	129-136	interleukin 1 beta	Homo sapiens	302-310
12577317-0	2003	Expression of interleukin-1 beta and interleukin-1 receptor antagonist in oxLDL-treated human aortic smooth muscle cells and in the neointima of cholesterol-fed endothelia-denuded rabbits.	Cholesterol	145-156	interleukin 1 beta	Homo sapiens	14-32
12579554-1	2003	The expression of interleukin-1beta (IL-1beta) messenger RNA (mRNA) in macrophage-like cells cultured on phospholipid polymers was evaluated to determine the extent of the inflammatory response.	phospholipid polymers	105-126	interleukin 1 beta	Homo sapiens	18-35
12579554-1	2003	The expression of interleukin-1beta (IL-1beta) messenger RNA (mRNA) in macrophage-like cells cultured on phospholipid polymers was evaluated to determine the extent of the inflammatory response.	phospholipid polymers	105-126	interleukin 1 beta	Homo sapiens	37-45
12579554-7	2003	When HL-60 cells were cultured on PMBs, the expression of IL-1beta mRNA in the cells was much less than that on the reference polymers.	(4-sulfophenyl)mercury	34-38	interleukin 1 beta	Homo sapiens	58-66
12579554-8	2003	In particular, the expression of IL-1beta mRNA in HL-60 cells cultured on the PMBs containing more than 10 mol % MPC units was not detected.	(4-sulfophenyl)mercury	78-82	interleukin 1 beta	Homo sapiens	33-41
12576215-6	2003	When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	166-197	interleukin 1 beta	Homo sapiens	82-104
12603824-7	2003	Caffeic acid phenethyl ester, a potent and specific inhibitor of activation of NF-kappaB, not only blocked IL-1beta-induced activation of the NF-kappaB promoter but also decreased IL-1beta-induced MIP-1alpha and -1beta expression in NT2-N cells.	caffeic acid phenethyl ester	0-28	interleukin 1 beta	Homo sapiens	107-115
12603824-7	2003	Caffeic acid phenethyl ester, a potent and specific inhibitor of activation of NF-kappaB, not only blocked IL-1beta-induced activation of the NF-kappaB promoter but also decreased IL-1beta-induced MIP-1alpha and -1beta expression in NT2-N cells.	caffeic acid phenethyl ester	0-28	interleukin 1 beta	Homo sapiens	180-188
12603855-5	2003	17beta-estradiol inhibited tumor necrosis factor-alpha or interleukin-1beta-induced RANTES secretion, mRNA expression, and promoter activity in keratinocytes, and these effects of 17beta-estradiol were counteracted by estrogen receptor antagonist ICI 182 780.	Estradiol	0-16	interleukin 1 beta	Homo sapiens	58-75
12603855-5	2003	17beta-estradiol inhibited tumor necrosis factor-alpha or interleukin-1beta-induced RANTES secretion, mRNA expression, and promoter activity in keratinocytes, and these effects of 17beta-estradiol were counteracted by estrogen receptor antagonist ICI 182 780.	Estradiol	180-196	interleukin 1 beta	Homo sapiens	58-75
12603855-6	2003	Two nuclear factor kappaB elements on RANTES promoter were required for tumor necrosis factor-alpha or interleukin-1beta-induced transcription and involved in the inhibition by 17beta-estradiol.	Estradiol	177-193	interleukin 1 beta	Homo sapiens	103-120
12755375-10	2003	When chondrocytes were incubated with IL-1beta, SIN-1 and ONOO dramatically decreased all gene expressions while SNAP was inefficient.	onoo	58-62	interleukin 1 beta	Homo sapiens	38-46
12755375-11	2003	H2O2 treatment inhibited both LPS and IL-1beta induced gene expressions.	Hydrogen Peroxide	0-4	interleukin 1 beta	Homo sapiens	38-46
12755375-1	2003	OBJECTIVES: To determine the regulatory effects of reactive oxygen species (ROS) on the expression by human osteoarthritic chondrocytes of interleukin (IL)-1beta, -6 and -8, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene in response to interleukin (IL)-1beta or lipopolysaccharide (LPS).	Reactive Oxygen Species	76-79	interleukin 1 beta	Homo sapiens	139-161
12755375-1	2003	OBJECTIVES: To determine the regulatory effects of reactive oxygen species (ROS) on the expression by human osteoarthritic chondrocytes of interleukin (IL)-1beta, -6 and -8, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene in response to interleukin (IL)-1beta or lipopolysaccharide (LPS).	Reactive Oxygen Species	76-79	interleukin 1 beta	Homo sapiens	262-284
12568957-10	2003	The IL-1 beta-treated tendon cells released prostaglandin E(2) (PGE(2)) in the medium, suggesting that the inducible COX2 catalyzed this synthesis.	Dinoprostone	44-62	interleukin 1 beta	Homo sapiens	4-13
12568957-10	2003	The IL-1 beta-treated tendon cells released prostaglandin E(2) (PGE(2)) in the medium, suggesting that the inducible COX2 catalyzed this synthesis.	Dinoprostone	64-70	interleukin 1 beta	Homo sapiens	4-13
12568957-11	2003	Induction of PGE(2) was detectable at 10 pM IL-1 beta.	Prostaglandins E	13-16	interleukin 1 beta	Homo sapiens	44-53
12612142-0	2003	Biotin supplementation increases expression of genes encoding interferon-gamma, interleukin-1beta, and 3-methylcrotonyl-CoA carboxylase, and decreases expression of the gene encoding interleukin-4 in human peripheral blood mononuclear cells.	Biotin	0-6	interleukin 1 beta	Homo sapiens	80-97
12612142-6	2003	The abundance of mRNA encoding interferon-gamma, interleukin-1beta, and 3-methylcrotonyl-CoA carboxylase was 4.3, 5.6 and 8.9 times greater, respectively, after supplementation with biotin compared with before supplementation.	Biotin	182-188	interleukin 1 beta	Homo sapiens	49-66
12631070-10	2003	One year after PTX, IL-1beta decreased from 23.6 +/- 7.5% to 9.9 +/- 3.1%, TNF-alpha from 4.5 +/- 1.5% to 0.7 +/- 0.8%, TGF-beta from 49.6 +/- 9.8% to 15.2 +/- 4.6%, and bFGF from 50.9 +/- 12.7% to 12.9 +/- 7.9% (P &lt; 0.001).	ptx	15-18	interleukin 1 beta	Homo sapiens	20-28
12710746-10	2003	CONCLUSIONS: Production by GF of numerous MMPs in response to IL-1beta was significantly reduced by progesterone.	Progesterone	100-112	interleukin 1 beta	Homo sapiens	62-70
12393527-8	2003	FADD-like interleukin 1 beta (IL-1beta)-converting enzyme (FLICE)-inhibitory protein (FLIP) has been reported to interact with FADD and/or caspase-8 at the death-inducing signaling complex (DISC) level following Fas stimulation and acts as a dominant-negative caspase-8.	ammonium ferrous sulfate	212-215	interleukin 1 beta	Homo sapiens	10-28
12573452-6	2003	Moreover, cyclooxygenase metabolites of EPA (PGs D3, E3 and I3) markedly potentiate IL-1beta-induced PGHS-2 expression, probably by increasing intracellular cAMP levels.	Eicosapentaenoic Acid	40-43	interleukin 1 beta	Homo sapiens	84-92
12573452-6	2003	Moreover, cyclooxygenase metabolites of EPA (PGs D3, E3 and I3) markedly potentiate IL-1beta-induced PGHS-2 expression, probably by increasing intracellular cAMP levels.	Cyclic AMP	157-161	interleukin 1 beta	Homo sapiens	84-92
12573452-0	2003	Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway.	Eicosapentaenoic Acid	14-35	interleukin 1 beta	Homo sapiens	39-47
12573452-2	2003	We established that among fish oil polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), but not docosahexaenoic acid (DHA), greatly decreased interleukin-1beta (IL-1beta)-induced PGHS-2 expression in human pulmonary microvascular endothelial cells (HPMECs).	Fatty Acids, Unsaturated	35-62	interleukin 1 beta	Homo sapiens	174-182
12573452-2	2003	We established that among fish oil polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), but not docosahexaenoic acid (DHA), greatly decreased interleukin-1beta (IL-1beta)-induced PGHS-2 expression in human pulmonary microvascular endothelial cells (HPMECs).	Eicosapentaenoic Acid	72-93	interleukin 1 beta	Homo sapiens	174-182
12573452-2	2003	We established that among fish oil polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), but not docosahexaenoic acid (DHA), greatly decreased interleukin-1beta (IL-1beta)-induced PGHS-2 expression in human pulmonary microvascular endothelial cells (HPMECs).	Eicosapentaenoic Acid	95-98	interleukin 1 beta	Homo sapiens	174-182
12574151-4	2003	IL-1beta (1 to 100 U/mL) dose-dependently stimulated not only iNOS but also DDAH expression and enzyme activity, accompanied by an increase in NO metabolite and by a decrease in ADMA content in culture media.	N,N-dimethylarginine	178-182	interleukin 1 beta	Homo sapiens	0-8
12566094-0	2003	Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid.	lenabasum	62-75	interleukin 1 beta	Homo sapiens	30-47
12566094-0	2003	Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid.	Cannabinoids	95-106	interleukin 1 beta	Homo sapiens	30-47
12566094-5	2003	Addition of AjA to PBM and SFM in vitro reduced both steady-state levels of IL-1beta mRNA and secretion of IL-1beta in a concentration-dependent manner.	lenabasum	12-15	interleukin 1 beta	Homo sapiens	76-84
12566094-5	2003	Addition of AjA to PBM and SFM in vitro reduced both steady-state levels of IL-1beta mRNA and secretion of IL-1beta in a concentration-dependent manner.	lenabasum	12-15	interleukin 1 beta	Homo sapiens	107-115
12566094-5	2003	Addition of AjA to PBM and SFM in vitro reduced both steady-state levels of IL-1beta mRNA and secretion of IL-1beta in a concentration-dependent manner.	phytobacteriomycin	19-22	interleukin 1 beta	Homo sapiens	76-84
12566094-5	2003	Addition of AjA to PBM and SFM in vitro reduced both steady-state levels of IL-1beta mRNA and secretion of IL-1beta in a concentration-dependent manner.	phytobacteriomycin	19-22	interleukin 1 beta	Homo sapiens	107-115
12566094-8	2003	Reduction of IL-1beta by AjA may help explain the therapeutic effects of AjA in the animal model of arthritis.	lenabasum	25-28	interleukin 1 beta	Homo sapiens	13-21
12566094-8	2003	Reduction of IL-1beta by AjA may help explain the therapeutic effects of AjA in the animal model of arthritis.	lenabasum	73-76	interleukin 1 beta	Homo sapiens	13-21
12574335-6	2003	Analysis of supernatants revealed that rNef treatment induced the release of macrophage inflammatory proteins 1alpha and 1beta, IL-1beta, IL-6, and TNF-alpha.	rnef	39-43	interleukin 1 beta	Homo sapiens	128-136
12574151-5	2003	A DDAH inhibitor (4124W, 5 mmol/L) augmented ADMA production (P&lt;0.01) and decreased NO synthesis (P&lt;0.01) in IL-1beta-stimulated SMCs.	N|O-Methyl L-Norarginine	18-23	interleukin 1 beta	Homo sapiens	115-123
12571865-7	2003	RESULTS: Our data revealed that GD potently inhibits the production of TNFalpha, interleukin-6 (IL-6), and IL-1beta in activated macrophages.	geldanamycin	32-34	interleukin 1 beta	Homo sapiens	107-115
12554939-1	2003	The crystal structure at 1.54 A resolution of a double mutant of interleukin-1beta (F42W/W120F), a cytokine secreted by macrophages, was determined by multiple-wavelength anomalous dispersion (MAD) using data from highly twinned selenomethionine-modified crystals.	Selenomethionine	229-245	interleukin 1 beta	Homo sapiens	65-82
12527330-7	2003	IL-1beta increased IL-6, IL-8, MIP-1beta, NO, PGE(2) and MMP-3 productions, but inhibited AGG and TIMP-1 synthesis.	Prostaglandins E	46-49	interleukin 1 beta	Homo sapiens	0-8
12527330-8	2003	Rhein partially reversed the effect of IL-1beta on TIMP-1 and NO production, had no effect on AGG, IL-6 and MIP-1beta production, but up-regulated the IL-1beta stimulated PGE(2) production.	Prostaglandins E	171-174	interleukin 1 beta	Homo sapiens	151-159
12562387-0	2003	Benzylpenicillin differentially conjugates to IFN-gamma, TNF-alpha, IL-1beta, IL-4 and IL-13 but selectively reduces IFN-gamma activity.	Penicillin G	0-16	interleukin 1 beta	Homo sapiens	68-76
12569071-0	2003	Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide.	Adenosine Triphosphate	27-30	interleukin 1 beta	Homo sapiens	0-17
12569071-0	2003	Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide.	Nitric Oxide	140-152	interleukin 1 beta	Homo sapiens	0-17
12569071-0	2003	Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide.	Ceramides	157-165	interleukin 1 beta	Homo sapiens	0-17
12569071-2	2003	In this study we report that the pro-inflammatory cytokine interleukin-1beta (IL-1beta) inhibits ATP-induced PKB activation.	Adenosine Triphosphate	97-100	interleukin 1 beta	Homo sapiens	59-76
12569071-2	2003	In this study we report that the pro-inflammatory cytokine interleukin-1beta (IL-1beta) inhibits ATP-induced PKB activation.	Adenosine Triphosphate	97-100	interleukin 1 beta	Homo sapiens	78-86
12569071-3	2003	2 Pretreatment of mesangial cells with IL-1beta leads to a time-dependent decrease of ATP-induced PKB phosphorylation.	Adenosine Triphosphate	86-89	interleukin 1 beta	Homo sapiens	39-47
12569071-5	2003	Incubating cells with IL-1beta in the presence of the NO synthase inhibitor, N-monomethyl-L-arginine (L-NMMA), reversed the IL-1beta inhibition of PKB activity.	omega-N-Methylarginine	77-100	interleukin 1 beta	Homo sapiens	22-30
12569071-5	2003	Incubating cells with IL-1beta in the presence of the NO synthase inhibitor, N-monomethyl-L-arginine (L-NMMA), reversed the IL-1beta inhibition of PKB activity.	omega-N-Methylarginine	77-100	interleukin 1 beta	Homo sapiens	124-132
12569071-5	2003	Incubating cells with IL-1beta in the presence of the NO synthase inhibitor, N-monomethyl-L-arginine (L-NMMA), reversed the IL-1beta inhibition of PKB activity.	omega-N-Methylarginine	102-108	interleukin 1 beta	Homo sapiens	22-30
12569071-5	2003	Incubating cells with IL-1beta in the presence of the NO synthase inhibitor, N-monomethyl-L-arginine (L-NMMA), reversed the IL-1beta inhibition of PKB activity.	omega-N-Methylarginine	102-108	interleukin 1 beta	Homo sapiens	124-132
12569071-7	2003	3 The NO- and IL-1beta-mediated delayed inhibition of PKB activity is completely reversed by the phosphatase inhibitor calyculin A, but not by ocadaic acid, suggesting that NO upregulates a protein phosphatase activity, which most probably belongs to the group of protein phosphatases type 1.	calyculin A	119-130	interleukin 1 beta	Homo sapiens	14-22
12569071-8	2003	4 In addition, IL-1beta also triggers a short-term and transient inhibitory effect on ATP-induced PKB activation which is maximal after 2-5 min of pre-incubation with IL-1beta.	Adenosine Triphosphate	86-89	interleukin 1 beta	Homo sapiens	15-23
12569071-8	2003	4 In addition, IL-1beta also triggers a short-term and transient inhibitory effect on ATP-induced PKB activation which is maximal after 2-5 min of pre-incubation with IL-1beta.	Adenosine Triphosphate	86-89	interleukin 1 beta	Homo sapiens	167-175
12569071-10	2003	Rather an involvement of the sphingolipid ceramide is likely, since IL-1beta triggers rapid ceramide formation and incubation of cells with the cell-permeable C6-ceramide blocked ATP-induced PKB phosphorylation.	N-caproylsphingosine	159-170	interleukin 1 beta	Homo sapiens	68-76
12569071-10	2003	Rather an involvement of the sphingolipid ceramide is likely, since IL-1beta triggers rapid ceramide formation and incubation of cells with the cell-permeable C6-ceramide blocked ATP-induced PKB phosphorylation.	Adenosine Triphosphate	179-182	interleukin 1 beta	Homo sapiens	68-76
12569071-11	2003	5 In summary, our data show that IL-1beta exerts both short-term and long-term inhibitory effects on ATP-stimulated PKB activation, the short-term effect probably involves ceramide formation, whereas the long-term effect is due to inducible NO synthase induction and subsequent NO formation.	Adenosine Triphosphate	101-104	interleukin 1 beta	Homo sapiens	33-41
12569071-11	2003	5 In summary, our data show that IL-1beta exerts both short-term and long-term inhibitory effects on ATP-stimulated PKB activation, the short-term effect probably involves ceramide formation, whereas the long-term effect is due to inducible NO synthase induction and subsequent NO formation.	Ceramides	172-180	interleukin 1 beta	Homo sapiens	33-41
12562387-6	2003	We demonstrate by Western blotting that BP also conjugates to IL-1beta, IL-2, IL-5, IL-13 and TNF-alpha but not to IL-10.	Penicillin G	40-42	interleukin 1 beta	Homo sapiens	62-70
12568852-5	2003	INTERVENTION(S): Confluent stromal cell cultures treated with steroid hormones were stimulated with IL-1beta and attenuated by anti-IL-1beta antibody or IL-1 receptor antagonist.	Steroids	62-78	interleukin 1 beta	Homo sapiens	100-108
12568852-5	2003	INTERVENTION(S): Confluent stromal cell cultures treated with steroid hormones were stimulated with IL-1beta and attenuated by anti-IL-1beta antibody or IL-1 receptor antagonist.	Steroids	62-78	interleukin 1 beta	Homo sapiens	132-140
12592549-0	2003	Induction of matrix metalloproteinase-2 and -3 activity in ovine nucleus pulposus cells grown in three-dimensional agarose gel culture by interleukin-1beta: a potential pathway of disc degeneration.	Sepharose	115-122	interleukin 1 beta	Homo sapiens	138-155
12627879-1	2003	In cultured vascular smooth muscle cells (VSMCs), interleukin-1beta (IL-1beta) stimulates inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production.	Nitric Oxide	100-112	interleukin 1 beta	Homo sapiens	50-67
12627879-1	2003	In cultured vascular smooth muscle cells (VSMCs), interleukin-1beta (IL-1beta) stimulates inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production.	Nitric Oxide	100-112	interleukin 1 beta	Homo sapiens	69-77
12675200-5	2003	OCE significantly inhibited the production of TNF-alpha, IL-1beta and interferon-gamma (INF-gamma), compared to absence of OCE.	oce	0-3	interleukin 1 beta	Homo sapiens	57-65
12627879-4	2003	Pretreatment with ONO-RS-082, the secretory PLA2 (sPLA2) inhibitor, at 1 to 10 micromol/l reduced IL-1beta-stimulated nitrite production and iNOS expression.	2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid	18-28	interleukin 1 beta	Homo sapiens	98-106
12627879-4	2003	Pretreatment with ONO-RS-082, the secretory PLA2 (sPLA2) inhibitor, at 1 to 10 micromol/l reduced IL-1beta-stimulated nitrite production and iNOS expression.	Nitrites	118-125	interleukin 1 beta	Homo sapiens	98-106
12627879-5	2003	Nordihydroguaiaretic acid (NDGA, 1 to 10 micromol/l), the LOX inhibitor, also reduced IL-1beta (10 ng/ml)-stimulated nitrite production and iNOS expression in a dose-dependent manner.	Masoprocol	0-25	interleukin 1 beta	Homo sapiens	86-94
12772775-7	2003	Notably, the hydrolysis products of the benzopyranyl ester, AL-5692 and (S)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid, were devoid of pharmacological activity when assessed for inhibition of monocyte adhesion or IL-1beta synthesis.	benzopyranyl ester	40-58	interleukin 1 beta	Homo sapiens	218-226
12627879-5	2003	Nordihydroguaiaretic acid (NDGA, 1 to 10 micromol/l), the LOX inhibitor, also reduced IL-1beta (10 ng/ml)-stimulated nitrite production and iNOS expression in a dose-dependent manner.	Masoprocol	27-31	interleukin 1 beta	Homo sapiens	86-94
12772775-7	2003	Notably, the hydrolysis products of the benzopyranyl ester, AL-5692 and (S)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid, were devoid of pharmacological activity when assessed for inhibition of monocyte adhesion or IL-1beta synthesis.	Aluminum	60-62	interleukin 1 beta	Homo sapiens	218-226
12627879-5	2003	Nordihydroguaiaretic acid (NDGA, 1 to 10 micromol/l), the LOX inhibitor, also reduced IL-1beta (10 ng/ml)-stimulated nitrite production and iNOS expression in a dose-dependent manner.	Nitrites	117-124	interleukin 1 beta	Homo sapiens	86-94
12627879-6	2003	Exogenous 12(S)-hydroxyeicosatetraenoic acids (HETE) enhanced the IL-1beta-stimulated nitrite production and iNOS expression.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	10-45	interleukin 1 beta	Homo sapiens	66-74
12627879-6	2003	Exogenous 12(S)-hydroxyeicosatetraenoic acids (HETE) enhanced the IL-1beta-stimulated nitrite production and iNOS expression.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	47-51	interleukin 1 beta	Homo sapiens	66-74
12627879-6	2003	Exogenous 12(S)-hydroxyeicosatetraenoic acids (HETE) enhanced the IL-1beta-stimulated nitrite production and iNOS expression.	Nitrites	86-93	interleukin 1 beta	Homo sapiens	66-74
12745547-0	2003	Dexamethasone prevents interleukin-1beta-induced nuclear factor-kappaB activation by upregulating IkappaB-alpha synthesis, in lymphoblastic cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	23-40
12569180-9	2003	Semi-quantitative RT-PCR and Southern blot analysis showed that IL-1beta also increased P-LAP mRNA, which was abrogated by prior exposure to cycloheximide.	Cycloheximide	141-154	interleukin 1 beta	Homo sapiens	64-72
12586608-4	2003	CS and CT strongly inhibited the production of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, IL-8, and TNF-alpha) from LPS-stimulated human monocytes.	Cesium	0-2	interleukin 1 beta	Homo sapiens	85-93
12586608-4	2003	CS and CT strongly inhibited the production of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, IL-8, and TNF-alpha) from LPS-stimulated human monocytes.	ct	7-9	interleukin 1 beta	Homo sapiens	85-93
12745547-4	2003	We also evaluated the ability of Dex to prevent the activation of NF-kappaB in response to the potent proinflammatory cytokine, interleukin (IL)-1beta.	Dexamethasone	33-36	interleukin 1 beta	Homo sapiens	128-150
12745547-8	2003	Finally, when the cells were exposed to Dex (1 microM) prior to stimulation with IL-1beta (20 ng/ml), Dex was efficient in preventing IL-1beta-induced NF-kappaB activation.	Dexamethasone	40-43	interleukin 1 beta	Homo sapiens	134-142
12745547-8	2003	Finally, when the cells were exposed to Dex (1 microM) prior to stimulation with IL-1beta (20 ng/ml), Dex was efficient in preventing IL-1beta-induced NF-kappaB activation.	Dexamethasone	102-105	interleukin 1 beta	Homo sapiens	81-89
12745547-8	2003	Finally, when the cells were exposed to Dex (1 microM) prior to stimulation with IL-1beta (20 ng/ml), Dex was efficient in preventing IL-1beta-induced NF-kappaB activation.	Dexamethasone	102-105	interleukin 1 beta	Homo sapiens	134-142
12745547-10	2003	CONCLUSION: Our results indicate that, in CCRF-CEM cells, Dex prevents NF-kappaB activation, induced by IL-1beta, by a mechanism that involves the upregulation of IkappaB-alpha synthesis, and that depends on the early and transient activation of NF-kappaB.	Dexamethasone	58-61	interleukin 1 beta	Homo sapiens	104-112
12517972-10	2003	Indo, NS-398, Flur, and 15d-PGJ(2), but not WY-14643, induced transcriptional activity of a COX-2 reporter construct containing the peroxisome proliferator response element (PPRE) on their own and enhanced the effect of IL-1beta, but had no effect on a COX-2 reporter construct lacking the PPRE.	Indomethacin	0-4	interleukin 1 beta	Homo sapiens	220-228
12666705-10	2003	The amount of IL-1beta increased in the CO2 group from baseline to 1 week (P &lt; 0.05).	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	40-43	interleukin 1 beta	Homo sapiens	14-22
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Indomethacin	27-39	interleukin 1 beta	Homo sapiens	157-165
12619182-6	2003	In the alendronate treated group, statistically significant changes occurred in the levels of serum IL-1alpha and IL-6 after three months, and in IL-1beta, IL-6, IL-6r and TNF-alpha after six months (p &lt; 0.05).	Alendronate	7-18	interleukin 1 beta	Homo sapiens	146-154
12568735-6	2003	After adjustment for potential confounding factors such as age, height, weight, years since menopause, and daily calcium intake, subjects with genotype E1/E2 (n=8) in IL-1beta exon 5 had lower BMD values and a significantly greater risk for osteoporosis (OR 10.6, 95% CI 1.3-83.8) at the lumbar spine when compared with subjects with genotype E1/E1 (n=164) in IL-1beta exon 5.	Calcium	113-120	interleukin 1 beta	Homo sapiens	167-175
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Indomethacin	41-45	interleukin 1 beta	Homo sapiens	157-165
12517972-10	2003	Indo, NS-398, Flur, and 15d-PGJ(2), but not WY-14643, induced transcriptional activity of a COX-2 reporter construct containing the peroxisome proliferator response element (PPRE) on their own and enhanced the effect of IL-1beta, but had no effect on a COX-2 reporter construct lacking the PPRE.	Nitrogen	6-8	interleukin 1 beta	Homo sapiens	220-228
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Flurbiprofen	48-60	interleukin 1 beta	Homo sapiens	157-165
12517972-10	2003	Indo, NS-398, Flur, and 15d-PGJ(2), but not WY-14643, induced transcriptional activity of a COX-2 reporter construct containing the peroxisome proliferator response element (PPRE) on their own and enhanced the effect of IL-1beta, but had no effect on a COX-2 reporter construct lacking the PPRE.	-pgj	27-31	interleukin 1 beta	Homo sapiens	220-228
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	Flurbiprofen	62-66	interleukin 1 beta	Homo sapiens	157-165
12517972-2	2003	We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	103-109	interleukin 1 beta	Homo sapiens	157-165
12543811-4	2003	In group I strains, mean basal and peak PGE2 levels after 24 h of interleukin (IL)-1beta stimulation were 5.4 +/- 1.1 and 32.8 +/- 4.9 ng/mg protein, respectively.	Dinoprostone	40-44	interleukin 1 beta	Homo sapiens	66-88
12543811-6	2003	IL-1beta-mediated stimulation of PGE2 was fully blocked in the presence of a nonselective COX inhibitor (indomethacin) or a selective COX-2 inhibitor (NS-398).	Dinoprostone	33-37	interleukin 1 beta	Homo sapiens	0-8
12517972-4	2003	Indeed, PGE(2) also induced and enhanced IL-1beta-induced COX-2 expression.	Prostaglandins E	8-11	interleukin 1 beta	Homo sapiens	41-49
12505195-4	2003	In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29.	pyrrolidine dithiocarbamic acid	96-122	interleukin 1 beta	Homo sapiens	133-141
12517972-8	2003	Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination.	Dexamethasone	18-31	interleukin 1 beta	Homo sapiens	118-126
12543811-6	2003	IL-1beta-mediated stimulation of PGE2 was fully blocked in the presence of a nonselective COX inhibitor (indomethacin) or a selective COX-2 inhibitor (NS-398).	Indomethacin	105-117	interleukin 1 beta	Homo sapiens	0-8
12543811-6	2003	IL-1beta-mediated stimulation of PGE2 was fully blocked in the presence of a nonselective COX inhibitor (indomethacin) or a selective COX-2 inhibitor (NS-398).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	151-157	interleukin 1 beta	Homo sapiens	0-8
12543811-9	2003	However, incubation of fibroblasts with PGE2 after IL-1beta stimulation prolonged COX-2 mRNA half-life from approximately 1 to 9 h. Our results strengthen the evidence that fibroblasts and other mesenchymal cells are the source of COX-2 expression in normal and premalignant colorectal tissue.	Dinoprostone	40-44	interleukin 1 beta	Homo sapiens	51-59
12505195-4	2003	In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29.	pyrrolidine dithiocarbamic acid	124-128	interleukin 1 beta	Homo sapiens	133-141
12406856-6	2003	In contrast, basal and IL-1beta-stimulated GM-CSF release, but not CSM-stimulated release, was inhibited by dexamethasone.	Dexamethasone	108-121	interleukin 1 beta	Homo sapiens	23-31
12388337-0	2003	Regulation of IL-1beta -induced GM-CSF production in human airway smooth muscle cells by carbon monoxide.	Carbon Monoxide	89-104	interleukin 1 beta	Homo sapiens	14-22
12388337-6	2003	Exposure of HASMC to CO at low concentration (250 ppm) markedly inhibited IL-1beta-induced GM-CSF synthesis (&gt;90%) compared with air-treated controls.	hasmc	12-17	interleukin 1 beta	Homo sapiens	74-82
12388337-6	2003	Exposure of HASMC to CO at low concentration (250 ppm) markedly inhibited IL-1beta-induced GM-CSF synthesis (&gt;90%) compared with air-treated controls.	Carbon Monoxide	21-23	interleukin 1 beta	Homo sapiens	74-82
12932294-3	2003	In this study, using prostaglandin E2 production as a measure of stimulation, we quantitatively compared the ability of anakinra, as well as that of IL-1Ra delivered by gene transfer, to inhibit the biologic actions of IL-1beta.	Dinoprostone	21-37	interleukin 1 beta	Homo sapiens	219-227
12507912-4	2003	Compared to non-CF cells, CF bronchial epithelial cells were characterized by a higher susceptibility to produce elevated IL-8 and RANTES production in an hypertonic NaCl milieu in response to IL-1beta activation.	Sodium Chloride	166-170	interleukin 1 beta	Homo sapiens	193-201
12502991-10	2003	In patients of the PA + PCEA group in the postoperative period, production of IL-1beta, IL-6, IL-1ra, and IL-10 was significantly less elevated, while IL-2 production was significantly less suppressed.	Protactinium	19-21	interleukin 1 beta	Homo sapiens	78-86
12502991-10	2003	In patients of the PA + PCEA group in the postoperative period, production of IL-1beta, IL-6, IL-1ra, and IL-10 was significantly less elevated, while IL-2 production was significantly less suppressed.	pcea	24-28	interleukin 1 beta	Homo sapiens	78-86
12492578-5	2003	Expression of CD80, CD83, CD86, and major histocompatibility complex class I and class II antigens were reduced on lipopolysaccharide (LPS)-matured leukaemic DC but were enhanced by a mixture of interleukin 1beta (IL-1beta), IL-6, tumour necrosis factor-alpha (TNF-alpha) and prostaglandin E2 (PGE2).	Dinoprostone	276-292	interleukin 1 beta	Homo sapiens	195-212
14979058-4	2003	TNF alpha and IL1 beta are major components of the inflammatory process: TNF alpha is an important stimulus of cells producing inflammatory mediators (cytokines, metalloproteinases, NO, PGE2,...) and IL1 beta mediates cartilage and bone destruction (via secretion of metalloproteinases, decrease synthesis of glycosaminoglycans...).	Glycosaminoglycans	309-327	interleukin 1 beta	Homo sapiens	14-22
12492578-5	2003	Expression of CD80, CD83, CD86, and major histocompatibility complex class I and class II antigens were reduced on lipopolysaccharide (LPS)-matured leukaemic DC but were enhanced by a mixture of interleukin 1beta (IL-1beta), IL-6, tumour necrosis factor-alpha (TNF-alpha) and prostaglandin E2 (PGE2).	Dinoprostone	294-298	interleukin 1 beta	Homo sapiens	195-212
14979058-4	2003	TNF alpha and IL1 beta are major components of the inflammatory process: TNF alpha is an important stimulus of cells producing inflammatory mediators (cytokines, metalloproteinases, NO, PGE2,...) and IL1 beta mediates cartilage and bone destruction (via secretion of metalloproteinases, decrease synthesis of glycosaminoglycans...).	Glycosaminoglycans	309-327	interleukin 1 beta	Homo sapiens	200-208
12519386-9	2003	Pharmacological inhibition of protein tyrosine phosphatases or treatment with mesalamine or sulphasalazine diminished IL-1 beta-stimulated IL-8 secretion by butyrate-exposed HT-29 cells substantially.	Butyrates	157-165	interleukin 1 beta	Homo sapiens	118-127
12519386-7	2003	Pointing to the potentially underlying mechanism of increased IL-1 beta-stimulated IL-8 secretion in HT-29 cells, butyrate up-regulated IL-1RI mRNA but not IL-1RII.	Butyrates	114-122	interleukin 1 beta	Homo sapiens	62-71
12519386-11	2003	Pharmacological inhibition of enhanced IL-1 beta-mediated IL-8 secretion in a subpopulation of IEC may improve the clinical efficacy of butyrate.	Butyrates	136-144	interleukin 1 beta	Homo sapiens	39-48
12519386-8	2003	Butyrate pretreatment of IEC lines stimulated by IL-1 beta modulated neutrophil migration significantly: reduction towards Caco-2 and enhancement towards HT-29/p cells.	Butyrates	0-8	interleukin 1 beta	Homo sapiens	49-58
12519386-9	2003	Pharmacological inhibition of protein tyrosine phosphatases or treatment with mesalamine or sulphasalazine diminished IL-1 beta-stimulated IL-8 secretion by butyrate-exposed HT-29 cells substantially.	Mesalamine	78-88	interleukin 1 beta	Homo sapiens	118-127
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	Tetracycline	23-49	interleukin 1 beta	Homo sapiens	183-192
12519386-9	2003	Pharmacological inhibition of protein tyrosine phosphatases or treatment with mesalamine or sulphasalazine diminished IL-1 beta-stimulated IL-8 secretion by butyrate-exposed HT-29 cells substantially.	Sulfasalazine	92-106	interleukin 1 beta	Homo sapiens	118-127
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	Tetracycline	23-35	interleukin 1 beta	Homo sapiens	183-192
12640327-31	2003	It has been shown that a dietary increase of polyunsaturated omega 3 fatty acids reduced strongly the production of IL-1 beta, IL-2, IL-6 and TNF-alpha (tumor necrosis factor-alpha).	polyunsaturated omega 3 fatty acids	45-80	interleukin 1 beta	Homo sapiens	116-125
12669266-5	2003	Metformin (0.1 - 10 mM) dose-dependently decreased PAI-1 production (and PAI-1 mRNA) under both basal (43 % inhibition at 10 mM, p &lt; 0.05) and interleukin-1beta (IL-1beta)-stimulated conditions where the levels were inhibited by 47.8 % at 1 mM metformin (p &lt; 0.05) and by 100 % at 10 mM (p &lt; 0.01).	Metformin	0-9	interleukin 1 beta	Homo sapiens	146-163
12669266-5	2003	Metformin (0.1 - 10 mM) dose-dependently decreased PAI-1 production (and PAI-1 mRNA) under both basal (43 % inhibition at 10 mM, p &lt; 0.05) and interleukin-1beta (IL-1beta)-stimulated conditions where the levels were inhibited by 47.8 % at 1 mM metformin (p &lt; 0.05) and by 100 % at 10 mM (p &lt; 0.01).	Metformin	0-9	interleukin 1 beta	Homo sapiens	165-173
12529415-7	2003	In conclusion, these findings indicate that IL-1beta not only induced GAG synthesis by increasing COX-2 protein expression and the subsequent PGE(2) production but also enhanced the responsiveness of cervical fibroblasts to PGE(2) by selectively up-regulating EP(4) receptor mRNA expression.	Prostaglandins E	224-227	interleukin 1 beta	Homo sapiens	44-52
12519881-11	2003	IL-1 beta also up-regulated 11 beta-HSD-1 activity maximally at 0.6 x 10(-9) M (160 +/- 33%; P &lt; 0.001) and caused an increase in glycerol levels (159 +/- 11% of control; P &lt; 0.001).	Glycerol	133-141	interleukin 1 beta	Homo sapiens	0-9
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	Curcumin	47-55	interleukin 1 beta	Homo sapiens	77-85
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	U 0126	188-193	interleukin 1 beta	Homo sapiens	77-85
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	195-203	interleukin 1 beta	Homo sapiens	77-85
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	SB 203580	209-217	interleukin 1 beta	Homo sapiens	77-85
12507586-3	2003	In this study we evaluated the role of epigallocatechin-3-gallate (EGCG), a green tea polyphenol which mimics its anti-inflammatory effects, in modulating the IL-1beta-induced activation of MAPK"s in human chondrocytes.	epigallocatechin gallate	39-65	interleukin 1 beta	Homo sapiens	159-167
12507586-3	2003	In this study we evaluated the role of epigallocatechin-3-gallate (EGCG), a green tea polyphenol which mimics its anti-inflammatory effects, in modulating the IL-1beta-induced activation of MAPK"s in human chondrocytes.	epigallocatechin gallate	67-71	interleukin 1 beta	Homo sapiens	159-167
12507586-3	2003	In this study we evaluated the role of epigallocatechin-3-gallate (EGCG), a green tea polyphenol which mimics its anti-inflammatory effects, in modulating the IL-1beta-induced activation of MAPK"s in human chondrocytes.	Polyphenols	86-96	interleukin 1 beta	Homo sapiens	159-167
12507586-4	2003	We discovered that EGCG inhibited the IL-1beta-induced phosphorylation of c-Jun N-terminal kinase (JNK) isoforms, accumulation of phospho-c-Jun and DNA binding activity of AP-1 in osteoarthritis (OA) chondrocytes.	epigallocatechin gallate	19-23	interleukin 1 beta	Homo sapiens	38-46
12507586-9	2003	These are novel findings and indicate that EGCG may be of potential benefit in inhibiting IL-1beta-induced catabolic effects in OA chondrocytes that are dependent on JNK activity.	epigallocatechin gallate	43-47	interleukin 1 beta	Homo sapiens	90-98
12849755-8	2003	In the third experiment, pretreatment with a selective 5-HT2 receptor antagonist, LY-53857, blocked the facilitating effects of interleukin-1beta upon defensive rage.	LY 53857	82-90	interleukin 1 beta	Homo sapiens	128-145
12691617-3	2003	LPS-TLR4-adapted human THP-1 promonocytic cells cross-adapt to lipoteichoic acid (LTA)-TLR2-induced IL-1beta/TNF-alpha production, suggesting disruption of a common intracellular signaling event(s).	lipoteichoic acid	63-80	interleukin 1 beta	Homo sapiens	100-108
12691617-3	2003	LPS-TLR4-adapted human THP-1 promonocytic cells cross-adapt to lipoteichoic acid (LTA)-TLR2-induced IL-1beta/TNF-alpha production, suggesting disruption of a common intracellular signaling event(s).	lipoteichoic acid	82-85	interleukin 1 beta	Homo sapiens	100-108
12496396-7	2003	Immunoneutralization studies indicated that TNF-alpha was a primary regulator of IL-1beta, IL-10, and PGE2 production, while IL-1beta stimulated only PGE2 production.	Dinoprostone	150-154	interleukin 1 beta	Homo sapiens	125-133
12436477-5	2003	The effect of ribavirin on IFN-gamma and IL-1beta release in the supernatant of unstimulated and phytohemagglutinin (PHA) stimulated PBMCs was investigated by enzyme linked immunosorbent assay (ELISA).	Ribavirin	14-23	interleukin 1 beta	Homo sapiens	41-49
12436477-7	2003	Ribavirin led to a dose-dependent decrease of the IFN-gamma but an increase of IL-1beta release into the supernatant of PHA-stimulated PBMCs.	Ribavirin	0-9	interleukin 1 beta	Homo sapiens	79-87
12508386-6	2003	RESULTS: Good (ACR 50-70) or excellent (ACR &gt; 70) responses to MTX treatment were seen in groups of patients with a higher proportion of males (25 and 43%) associated with a significantly lower ratio of IL-1ra/IL-1beta (p &lt; 0.00001) constitutively produced by PBMC (ratio &lt; 100) compared with nonresponding (ACR &lt; 20) patients (males 7.7%; ratio &gt; 100).	Methotrexate	66-69	interleukin 1 beta	Homo sapiens	213-221
12508386-11	2003	CONCLUSION: Determination of cellularly produced IL-1beta and even more of the IL-1ra/IL-1beta synthesis in PBMC may be useful to predict the outcome of RA patients undergoing treatment with MTX and may characterize a subset of RA that is more responsive to IL-1 directed therapeutic interventions.	Methotrexate	191-194	interleukin 1 beta	Homo sapiens	49-57
12508386-11	2003	CONCLUSION: Determination of cellularly produced IL-1beta and even more of the IL-1ra/IL-1beta synthesis in PBMC may be useful to predict the outcome of RA patients undergoing treatment with MTX and may characterize a subset of RA that is more responsive to IL-1 directed therapeutic interventions.	Methotrexate	191-194	interleukin 1 beta	Homo sapiens	86-94
12529415-0	2003	Interleukin-1beta induces glycosaminoglycan synthesis via the prostaglandin E2 pathway in cultured human cervical fibroblasts.	Glycosaminoglycans	26-43	interleukin 1 beta	Homo sapiens	0-17
12529415-0	2003	Interleukin-1beta induces glycosaminoglycan synthesis via the prostaglandin E2 pathway in cultured human cervical fibroblasts.	Dinoprostone	62-78	interleukin 1 beta	Homo sapiens	0-17
12529415-1	2003	The aim of this study was to identify, in cultured human cervical fibroblasts, the mechanisms by which interleukin (IL)-1beta induces the synthesis of glycosaminoglycans (GAG) and to explore the putative role of prostaglandin E(2) (PGE(2)) in this process.	Glycosaminoglycans	151-169	interleukin 1 beta	Homo sapiens	103-125
12529415-1	2003	The aim of this study was to identify, in cultured human cervical fibroblasts, the mechanisms by which interleukin (IL)-1beta induces the synthesis of glycosaminoglycans (GAG) and to explore the putative role of prostaglandin E(2) (PGE(2)) in this process.	Glycosaminoglycans	171-174	interleukin 1 beta	Homo sapiens	103-125
12529415-1	2003	The aim of this study was to identify, in cultured human cervical fibroblasts, the mechanisms by which interleukin (IL)-1beta induces the synthesis of glycosaminoglycans (GAG) and to explore the putative role of prostaglandin E(2) (PGE(2)) in this process.	Dinoprostone	232-238	interleukin 1 beta	Homo sapiens	103-125
12676149-5	2003	We found that ibotenic acid lesions of the PVN significantly reduced numbers of Fos-positive non-catecholamine, noradrenergic and adrenergic cells observable in the VLM and NTS after interleukin-1beta administration.	Ibotenic Acid	14-27	interleukin 1 beta	Homo sapiens	183-200
14526152-10	2003	The effects of IL-1beta and TNF-alpha were significantly inhibited by PD98059 MEK/ERK inhibitor).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	70-77	interleukin 1 beta	Homo sapiens	15-23
12529415-2	2003	Exposure of the cells for 24 h to IL-1beta induced a significant (P &lt; 0.05) dose-dependent increase in GAG synthesis.	Glycosaminoglycans	106-109	interleukin 1 beta	Homo sapiens	34-42
12529415-3	2003	IL-1beta (1 ng/ml) induced the expression of cyclooxygenase-2 (COX-2) protein 6 h after treatment, accompanied by a 7.5-fold increase in PGE(2) production.	Prostaglandins E	137-140	interleukin 1 beta	Homo sapiens	0-8
12529415-4	2003	We confirmed that NS398, a selective COX-2 inhibitor, dose-dependently blocked PGE(2) augmentation following IL-1beta treatment.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	18-23	interleukin 1 beta	Homo sapiens	109-117
12529415-4	2003	We confirmed that NS398, a selective COX-2 inhibitor, dose-dependently blocked PGE(2) augmentation following IL-1beta treatment.	Prostaglandins E	79-82	interleukin 1 beta	Homo sapiens	109-117
12529415-5	2003	AH23848, the selective EP(4) receptor antagonist, completely abolished IL-1beta-induced GAG synthesis, whereas AH6809, an EP(2) receptor antagonist, had no effect on the stimulatory effects of IL-1beta.	AH 23848	0-7	interleukin 1 beta	Homo sapiens	71-79
12529415-5	2003	AH23848, the selective EP(4) receptor antagonist, completely abolished IL-1beta-induced GAG synthesis, whereas AH6809, an EP(2) receptor antagonist, had no effect on the stimulatory effects of IL-1beta.	Glycosaminoglycans	88-91	interleukin 1 beta	Homo sapiens	71-79
12529415-7	2003	In conclusion, these findings indicate that IL-1beta not only induced GAG synthesis by increasing COX-2 protein expression and the subsequent PGE(2) production but also enhanced the responsiveness of cervical fibroblasts to PGE(2) by selectively up-regulating EP(4) receptor mRNA expression.	Glycosaminoglycans	70-73	interleukin 1 beta	Homo sapiens	44-52
12529415-7	2003	In conclusion, these findings indicate that IL-1beta not only induced GAG synthesis by increasing COX-2 protein expression and the subsequent PGE(2) production but also enhanced the responsiveness of cervical fibroblasts to PGE(2) by selectively up-regulating EP(4) receptor mRNA expression.	Prostaglandins E	142-145	interleukin 1 beta	Homo sapiens	44-52
12388341-9	2002	Indomethacin, the MEK and p38 inhibitors U-0126 and SB-203580, the protein kinase A inhibitor H-89, and dexamethasone each completely abolished the ability of IL-1beta to induce CRE-driven gene expression but only slightly increased the ability of ISO to induce CRE-driven gene expression in IL-1beta-treated cells.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	94-98	interleukin 1 beta	Homo sapiens	159-167
12444300-6	2003	Moreover, TAC-101 inhibited the IL-1beta-induced PGE(2) production by MG-63 cells, human osteoblast-like cells, through the suppression of cyclooxygenase II mRNA expression.	Prostaglandins E	49-52	interleukin 1 beta	Homo sapiens	32-40
12388341-1	2002	IL-1beta inhibits isoproterenol (ISO)-induced relaxation of cultured human airway smooth muscle (HASM) cells.	Isoproterenol	18-31	interleukin 1 beta	Homo sapiens	0-8
12388341-1	2002	IL-1beta inhibits isoproterenol (ISO)-induced relaxation of cultured human airway smooth muscle (HASM) cells.	Isoproterenol	33-36	interleukin 1 beta	Homo sapiens	0-8
12388341-2	2002	The purpose of this study was to determine whether IL-1beta can also suppress ISO-induced cAMP response element (CRE)-dependent gene expression.	Cyclic AMP	90-94	interleukin 1 beta	Homo sapiens	51-59
12422373-2	2003	Here we report that at Schaffer collateral-CA1 synapses, bath application of IL-1beta induces a long-lasting decrease in synaptic strength in intact slices, but not in disinhibited slices in the presence of bicuculline, a gamma-aminobutyric acid receptor antagonist.	Bicuculline	207-218	interleukin 1 beta	Homo sapiens	77-85
12460645-0	2002	Aerosolized adrenomedullin suppresses pulmonary transforming growth factor-beta1 and interleukin-1 beta gene expression in vivo.	Adrenomedullin	12-26	interleukin 1 beta	Homo sapiens	85-103
12550106-8	2002	Likewise, interleukin (IL)-1beta concentration was decreased to 60%, 30% and 40% by 10(-6)M PGE(1), PGE(2) and PGE(3), respectively.	Prostaglandins E	92-95	interleukin 1 beta	Homo sapiens	10-32
12550106-8	2002	Likewise, interleukin (IL)-1beta concentration was decreased to 60%, 30% and 40% by 10(-6)M PGE(1), PGE(2) and PGE(3), respectively.	Prostaglandins E	100-103	interleukin 1 beta	Homo sapiens	10-32
12550106-8	2002	Likewise, interleukin (IL)-1beta concentration was decreased to 60%, 30% and 40% by 10(-6)M PGE(1), PGE(2) and PGE(3), respectively.	Prostaglandins E	100-103	interleukin 1 beta	Homo sapiens	10-32
12550106-11	2002	CONCLUSIONS: PGE inhibit lipopolysaccharide-stimulated TNF-alpha and IL-1beta production in human whole blood cultures.	Prostaglandins E	13-16	interleukin 1 beta	Homo sapiens	69-77
12388341-9	2002	Indomethacin, the MEK and p38 inhibitors U-0126 and SB-203580, the protein kinase A inhibitor H-89, and dexamethasone each completely abolished the ability of IL-1beta to induce CRE-driven gene expression but only slightly increased the ability of ISO to induce CRE-driven gene expression in IL-1beta-treated cells.	Dexamethasone	104-117	interleukin 1 beta	Homo sapiens	159-167
12444029-6	2002	Human bronchial smooth muscle cells and fibroblasts do not constitutively express ESE-3; however, after stimulation with interleukin-1beta or tumor necrosis factor-alpha, levels of ESE-3 mRNA and protein increase dramatically by 24 h. This cytokine induction is dose-dependent and abrogated by specific inhibitors of the MEK1/2 (U0126) and p38 (SB03580) signal transduction pathways.	U 0126	329-334	interleukin 1 beta	Homo sapiens	121-169
12388341-9	2002	Indomethacin, the MEK and p38 inhibitors U-0126 and SB-203580, the protein kinase A inhibitor H-89, and dexamethasone each completely abolished the ability of IL-1beta to induce CRE-driven gene expression but only slightly increased the ability of ISO to induce CRE-driven gene expression in IL-1beta-treated cells.	Dexamethasone	104-117	interleukin 1 beta	Homo sapiens	292-300
12388341-10	2002	IL-1beta also attenuated dibutyryl cAMP-induced CRE-driven gene expression, but not dibutyryl cAMP-induced CREB phosphorylation.	dibutyryl	25-34	interleukin 1 beta	Homo sapiens	0-8
12444029-6	2002	Human bronchial smooth muscle cells and fibroblasts do not constitutively express ESE-3; however, after stimulation with interleukin-1beta or tumor necrosis factor-alpha, levels of ESE-3 mRNA and protein increase dramatically by 24 h. This cytokine induction is dose-dependent and abrogated by specific inhibitors of the MEK1/2 (U0126) and p38 (SB03580) signal transduction pathways.	sb03580	345-352	interleukin 1 beta	Homo sapiens	121-169
12388341-4	2002	This effect of IL-1beta was abolished by the cyclooxygenase (COX) inhibitor indomethacin.	Indomethacin	76-88	interleukin 1 beta	Homo sapiens	15-23
12388341-9	2002	Indomethacin, the MEK and p38 inhibitors U-0126 and SB-203580, the protein kinase A inhibitor H-89, and dexamethasone each completely abolished the ability of IL-1beta to induce CRE-driven gene expression but only slightly increased the ability of ISO to induce CRE-driven gene expression in IL-1beta-treated cells.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	159-167
12388341-10	2002	IL-1beta also attenuated dibutyryl cAMP-induced CRE-driven gene expression, but not dibutyryl cAMP-induced CREB phosphorylation.	Cyclic AMP	35-39	interleukin 1 beta	Homo sapiens	0-8
12388341-9	2002	Indomethacin, the MEK and p38 inhibitors U-0126 and SB-203580, the protein kinase A inhibitor H-89, and dexamethasone each completely abolished the ability of IL-1beta to induce CRE-driven gene expression but only slightly increased the ability of ISO to induce CRE-driven gene expression in IL-1beta-treated cells.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	292-300
12493070-2	2002	A similar change in the rate of oxygen consumption is observed when Caco-2 human enterocyte-like cells are incubated in vitro with cytomix, a cocktail of cytokines containing tumor necrosis factor, IL-1beta, and IFN-gamma.	Oxygen	32-38	interleukin 1 beta	Homo sapiens	198-206
12388341-9	2002	Indomethacin, the MEK and p38 inhibitors U-0126 and SB-203580, the protein kinase A inhibitor H-89, and dexamethasone each completely abolished the ability of IL-1beta to induce CRE-driven gene expression but only slightly increased the ability of ISO to induce CRE-driven gene expression in IL-1beta-treated cells.	U 0126	41-47	interleukin 1 beta	Homo sapiens	159-167
12388341-9	2002	Indomethacin, the MEK and p38 inhibitors U-0126 and SB-203580, the protein kinase A inhibitor H-89, and dexamethasone each completely abolished the ability of IL-1beta to induce CRE-driven gene expression but only slightly increased the ability of ISO to induce CRE-driven gene expression in IL-1beta-treated cells.	SB 203580	52-61	interleukin 1 beta	Homo sapiens	159-167
12483719-10	2002	Interleukin-1beta had a weak enhancing effect on celecoxib-induced apoptosis in RASFs.	Celecoxib	49-58	interleukin 1 beta	Homo sapiens	0-17
12446609-4	2002	This study investigated the influence of a nonselective COX-inhibitor ketorolac on IL-1beta- and TNFalpha-induced expression of proinflammatory genes in the brain.	Ketorolac	70-79	interleukin 1 beta	Homo sapiens	83-91
12446609-9	2002	In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium.	Corticosterone	23-37	interleukin 1 beta	Homo sapiens	76-84
12446609-9	2002	In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium.	Ketorolac	63-72	interleukin 1 beta	Homo sapiens	76-84
12406386-6	2002	15-Deoxy-D12,14 prostaglandinJ2 also inhibited the adhesion of blood mononuclear cellsto endothelial monolayers treated with IFN-gamma or IL-1beta.	15-deoxy-d12	0-12	interleukin 1 beta	Homo sapiens	138-146
12406386-6	2002	15-Deoxy-D12,14 prostaglandinJ2 also inhibited the adhesion of blood mononuclear cellsto endothelial monolayers treated with IFN-gamma or IL-1beta.	14 prostaglandinj2	13-31	interleukin 1 beta	Homo sapiens	138-146
12469908-8	2002	In vitro, the Smads were also expressed and partly up-regulated by Il-1beta in alginate bead culture.	Alginates	79-87	interleukin 1 beta	Homo sapiens	67-75
12466348-2	2002	They trigger an increase in proinflammatory cytokines, in particular IL-1beta, that induces a cascade of events resulting in the production of potent effectors of myometrial contractility, such as the prostaglandin E(2) (PGE(2)).	Dinoprostone	201-219	interleukin 1 beta	Homo sapiens	69-77
12466348-2	2002	They trigger an increase in proinflammatory cytokines, in particular IL-1beta, that induces a cascade of events resulting in the production of potent effectors of myometrial contractility, such as the prostaglandin E(2) (PGE(2)).	Prostaglandins E	221-224	interleukin 1 beta	Homo sapiens	69-77
12466348-5	2002	The IL-1beta-induced PDE4 activity occurs after an increase in PGE(2) production and subsequent cAMP augmentation.	Dinoprostone	63-69	interleukin 1 beta	Homo sapiens	4-12
12466348-5	2002	The IL-1beta-induced PDE4 activity occurs after an increase in PGE(2) production and subsequent cAMP augmentation.	Cyclic AMP	96-100	interleukin 1 beta	Homo sapiens	4-12
12466348-6	2002	Pretreatment with indomethacin or NS 398 completely blocked this long-term effect of IL-1beta, revealing a PGE(2)-dependent pathway.	Indomethacin	18-30	interleukin 1 beta	Homo sapiens	85-93
12466348-6	2002	Pretreatment with indomethacin or NS 398 completely blocked this long-term effect of IL-1beta, revealing a PGE(2)-dependent pathway.	Dinoprostone	107-113	interleukin 1 beta	Homo sapiens	85-93
12444153-5	2002	Pretreatment of airway epithelial cells with BK or IL-1beta enhanced SDF-1alpha induced phospho-extracellular signal-regulated kinase and calcium mobilization, in addition to increasing the level of CXCR4 protein.	Calcium	138-145	interleukin 1 beta	Homo sapiens	51-59
12438339-2	2002	We found that Ec-LPS induced tolerance in THP-1 cells to subsequent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) induction by Pg-LPS, though the reverse was not true, and looked for explanatory differential effects on the signal transduction pathway.	ec-lps	14-20	interleukin 1 beta	Homo sapiens	112-130
12438339-2	2002	We found that Ec-LPS induced tolerance in THP-1 cells to subsequent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) induction by Pg-LPS, though the reverse was not true, and looked for explanatory differential effects on the signal transduction pathway.	ec-lps	14-20	interleukin 1 beta	Homo sapiens	132-140
12438339-2	2002	We found that Ec-LPS induced tolerance in THP-1 cells to subsequent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) induction by Pg-LPS, though the reverse was not true, and looked for explanatory differential effects on the signal transduction pathway.	pg-lps	155-161	interleukin 1 beta	Homo sapiens	112-130
12438339-2	2002	We found that Ec-LPS induced tolerance in THP-1 cells to subsequent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) induction by Pg-LPS, though the reverse was not true, and looked for explanatory differential effects on the signal transduction pathway.	pg-lps	155-161	interleukin 1 beta	Homo sapiens	132-140
12464933-6	2002	IL-1beta and TNF-alpha also inhibit the ability of beta-agonists to drive airway smooth muscle gene expression through pathways dependent on cyclic AMP response elements.	Cyclic AMP	141-151	interleukin 1 beta	Homo sapiens	0-8
12466036-10	2002	Pro-inflammatory cytokines such as IL-1beta, IFN-alpha, IFN-gamma and TNF-alpha affect the 5-HT metabolism directly and/or indirectly by stimulating the enzyme indoleamine 2,3-dioxygenase which leads to a peripheral depletion of tryptophan.	Tryptophan	229-239	interleukin 1 beta	Homo sapiens	35-43
12492908-8	2002	When subjects rinsed with 0.12% chlorhexidine during the 3-day no-brushing period, the increases in plaque index, GCF flow rates and IL-1b release rates did not occur.	Chlorhexidine	32-45	interleukin 1 beta	Homo sapiens	133-138
12512699-7	2002	Actinomycin D, a classical transcription inhibitor, was used to prove that indeed IL-1beta induced the functional PGE-S enzyme.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	82-90
12438537-5	2002	Inhibition of p38 mitogen-activated protein kinase (MAPK) with SB203580 substantially inhibited Con A- or IL-1beta-induced DNA binding activity of NF-kappaB, whereas ZnTMPyP inhibited the activation of p38 MAPK.	SB 203580	63-71	interleukin 1 beta	Homo sapiens	106-114
12482999-5	2002	PD98059 (MEK/ERK inhibitor) suppressed IL-1beta-mediated MUC2 gene expression and mucin secretion, while SB203580 (p38 inhibitor) did not.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Homo sapiens	39-47
12482999-6	2002	Ro31-8220 (PKC inhibitor) inhibited IL-1beta-mediated MUC2 gene expression and mucin secretion.	Ro 31-8220	0-9	interleukin 1 beta	Homo sapiens	36-44
12438537-3	2002	The results indicate that ZnTMPyP inhibited thymocyte proliferation stimulated with various mitogenic factors, such as concanavalin A (Con A), interleukin (IL)-1beta, and lipopolysaccharide-exposed macrophage supernatant, in a concentration-dependent manner.	zntmpyp	26-33	interleukin 1 beta	Homo sapiens	143-165
12438537-4	2002	ZnTMPyP was also effective in preventing DNA binding activity of nuclear factor kappaB (NF-kappaB) and IL-2 production by thymocytes in response to Con A or IL-1beta.	zntmpyp	0-7	interleukin 1 beta	Homo sapiens	157-165
12512699-11	2002	It means that IL-1beta-triggered-PGE2 biosynthesis in endothelial cells is probably regulated by induction of both COX-2 and PGE-S.	Dinoprostone	33-37	interleukin 1 beta	Homo sapiens	14-22
12635880-1	2002	Our objective was to evaluate the effect of intravenous magnesium sulphate administration to patients with preterm labour on maternal serum and amniotic fluid IL-1beta, IL-6, IL-10 and TNFalpha concentrations.	Magnesium Sulfate	56-74	interleukin 1 beta	Homo sapiens	159-167
12417342-6	2002	Inflammatory cytokines tumour necrosis factor alpha and interleukin 1 beta contribute to this up-regulation by increasing intracellular ROS production.	Reactive Oxygen Species	136-139	interleukin 1 beta	Homo sapiens	56-74
12464556-9	2002	Corticoid Dexamethasone inhibits IL-1beta and TNFalpha synthesis at IC(50) of 38 nM and 25 nM, respectively.	Dexamethasone	10-23	interleukin 1 beta	Homo sapiens	33-41
12464556-10	2002	ERK1/ERK2 inhibitor U0126 effects cytokine synthesis at IC(50) of 0.34 microM for IL-1beta production and 0.26 microM for TNFalpha synthesis.p38-MAP kinase inhibitor SB 203580 inhibits IL-1beta- and TNF-alpha-synthesis (IC(50)sof 0.052 microM and 0.46 microM) in the same degree as p38-MAP kinase activity (IC(50): 0.34 microM).	U 0126	20-25	interleukin 1 beta	Homo sapiens	82-90
12464556-10	2002	ERK1/ERK2 inhibitor U0126 effects cytokine synthesis at IC(50) of 0.34 microM for IL-1beta production and 0.26 microM for TNFalpha synthesis.p38-MAP kinase inhibitor SB 203580 inhibits IL-1beta- and TNF-alpha-synthesis (IC(50)sof 0.052 microM and 0.46 microM) in the same degree as p38-MAP kinase activity (IC(50): 0.34 microM).	U 0126	20-25	interleukin 1 beta	Homo sapiens	185-193
12464556-10	2002	ERK1/ERK2 inhibitor U0126 effects cytokine synthesis at IC(50) of 0.34 microM for IL-1beta production and 0.26 microM for TNFalpha synthesis.p38-MAP kinase inhibitor SB 203580 inhibits IL-1beta- and TNF-alpha-synthesis (IC(50)sof 0.052 microM and 0.46 microM) in the same degree as p38-MAP kinase activity (IC(50): 0.34 microM).	SB 203580	166-175	interleukin 1 beta	Homo sapiens	185-193
12464556-11	2002	Same results could be shown for SB 210313, which had same efficacy on IL-1beta and TNFalpha biosynthesis (IC(50)"s: 1.88 microM and 1.01 microM) and on p38-MAP kinase (IC(50): 6.85 microM).	1-(3-(4-morpholinyl)propyl)-4-(4-fluorophenyl)-5-(4-pyridyl)imidazole	32-41	interleukin 1 beta	Homo sapiens	70-78
12417253-0	2002	Effects of sphondin, isolated from Heracleum laciniatum, on IL-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells.	sphondin	11-19	interleukin 1 beta	Homo sapiens	60-68
12417253-1	2002	Recently, under large-scale screening experiments, we found that sphondin, a furanocoumarin derivative isolated from Heracleum laciniatum, possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.	sphondin	65-73	interleukin 1 beta	Homo sapiens	173-181
12417253-1	2002	Recently, under large-scale screening experiments, we found that sphondin, a furanocoumarin derivative isolated from Heracleum laciniatum, possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.	Furocoumarins	77-91	interleukin 1 beta	Homo sapiens	173-181
12417253-1	2002	Recently, under large-scale screening experiments, we found that sphondin, a furanocoumarin derivative isolated from Heracleum laciniatum, possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.	Dinoprostone	233-239	interleukin 1 beta	Homo sapiens	173-181
12417253-2	2002	Accordingly, we examined in the present study the action mechanism of sphondin on the inhibition of IL-1beta-induced COX-2 protein expression and PGE(2) release in a human pulmonary epithelial cell line (A549).	sphondin	70-78	interleukin 1 beta	Homo sapiens	100-108
12417253-3	2002	Pretreatment of cells with sphondin (10-50 microM) concentration-dependently attenuated IL-1beta-induced COX-2 protein expression and PGE(2) release.	sphondin	27-35	interleukin 1 beta	Homo sapiens	88-96
12417253-3	2002	Pretreatment of cells with sphondin (10-50 microM) concentration-dependently attenuated IL-1beta-induced COX-2 protein expression and PGE(2) release.	Prostaglandins E	134-137	interleukin 1 beta	Homo sapiens	88-96
12417253-4	2002	The IL-1beta-induced increase in COX-2 mRNA expression was also attenuated by sphondin (50 microM).	sphondin	78-86	interleukin 1 beta	Homo sapiens	4-12
12417253-7	2002	Treatment of cells with sphondin (50 microM) or the NF-kappaB inhibitor, PDTC (50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol and translocation of p65 NF-kappaB from the cytosol to the nucleus.	sphondin	24-32	interleukin 1 beta	Homo sapiens	110-118
12417253-8	2002	Furthermore, IL-1beta-induced NF-kappaB-specific DNA-protein complex formation in the nucleus was partially inhibited by sphondin (50 microM) or PDTC (50 microM).	sphondin	121-129	interleukin 1 beta	Homo sapiens	13-21
12417253-9	2002	Taken together, we demonstrate that sphondin inhibits IL-1beta-induced PGE(2) release in A549 cells; this inhibition is mediated by suppressing of COX-2 expression, rather than by inhibiting COX-2 enzyme activity.	sphondin	36-44	interleukin 1 beta	Homo sapiens	54-62
12417253-9	2002	Taken together, we demonstrate that sphondin inhibits IL-1beta-induced PGE(2) release in A549 cells; this inhibition is mediated by suppressing of COX-2 expression, rather than by inhibiting COX-2 enzyme activity.	Dinoprostone	71-77	interleukin 1 beta	Homo sapiens	54-62
12417253-10	2002	The inhibitory mechanism of sphondin on IL-1beta-induced COX-2 expression may be, at least in part, through suppression of NF-kappaB activity.	sphondin	28-36	interleukin 1 beta	Homo sapiens	40-48
12399621-0	2002	Exogenous nitric oxide inhibits tumor necrosis factor-alpha- or interleukin-1-beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells.	Nitric Oxide	10-22	interleukin 1 beta	Homo sapiens	64-82
12215436-5	2002	PGE(2) also inhibited the tumor necrosis factor-alpha-, interferon-gamma-, and interleukin-1beta-mediated expression of these chemokines.	Dinoprostone	0-5	interleukin 1 beta	Homo sapiens	79-96
12384474-4	2002	Apoptosis in response to IL-1beta was attenuated by the caspase-3 inhibitor [Z-Asp-Glu-Val-Asp-fluoromethyl ketone (Z-DVED-FMK)] but not by inhibition of guanylyl cyclase with 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ).	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	77-114	interleukin 1 beta	Homo sapiens	25-33
12436048-9	2002	RESULTS: Our results indicate that acute alcohol inhibits IL-1beta- and TNFalpha-induced NF-kappaB activation.	Alcohols	41-48	interleukin 1 beta	Homo sapiens	58-66
12384474-4	2002	Apoptosis in response to IL-1beta was attenuated by the caspase-3 inhibitor [Z-Asp-Glu-Val-Asp-fluoromethyl ketone (Z-DVED-FMK)] but not by inhibition of guanylyl cyclase with 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ).	z-dved-fmk	116-126	interleukin 1 beta	Homo sapiens	25-33
12384474-4	2002	Apoptosis in response to IL-1beta was attenuated by the caspase-3 inhibitor [Z-Asp-Glu-Val-Asp-fluoromethyl ketone (Z-DVED-FMK)] but not by inhibition of guanylyl cyclase with 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ).	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	176-219	interleukin 1 beta	Homo sapiens	25-33
12384474-4	2002	Apoptosis in response to IL-1beta was attenuated by the caspase-3 inhibitor [Z-Asp-Glu-Val-Asp-fluoromethyl ketone (Z-DVED-FMK)] but not by inhibition of guanylyl cyclase with 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ).	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	221-224	interleukin 1 beta	Homo sapiens	25-33
12384353-3	2002	Azithromycin decreased the tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 production from Stx-treated human peripheral mononuclear cells or monocytes to a greater extent than did clarithromycin.	Azithromycin	0-12	interleukin 1 beta	Homo sapiens	68-85
12384353-3	2002	Azithromycin decreased the tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 production from Stx-treated human peripheral mononuclear cells or monocytes to a greater extent than did clarithromycin.	Azithromycin	0-12	interleukin 1 beta	Homo sapiens	87-95
12428247-0	2002	Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells.	Ciprofloxacin	0-13	interleukin 1 beta	Homo sapiens	83-100
12428247-9	2002	Preincubation with ciprofloxacin potentiated IL-1beta-stimulated MMP-3 output, reflecting a similar effect on MMP-3 mRNA expression.	Ciprofloxacin	19-32	interleukin 1 beta	Homo sapiens	45-53
12428247-10	2002	Ciprofloxacin also potentiated IL-1beta-stimulated MMP-1 mRNA expression, but did not potentiate the output of MMP-1, and had no significant effects on MMP-2 mRNA expression or output.	Ciprofloxacin	0-13	interleukin 1 beta	Homo sapiens	31-39
12510792-7	2002	In addition, Dodutang potently inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells.	Calcimycin	180-186	interleukin 1 beta	Homo sapiens	99-121
12404229-7	2002	Lipopolysaccharide and titanium dioxide had no additional effect, but calcium, and more so the conjugate, induced interleukin-1beta release in proportion to the degree of inflammation.	Calcium	70-77	interleukin 1 beta	Homo sapiens	114-131
12404229-10	2002	In peripheral blood mononuclear cells, inhibition of caspase 1 reduced interleukin-1beta secretion, whereas blockade of phagocytosis inhibited calcium-induced apoptosis and interleukin-1beta release.	Calcium	143-150	interleukin 1 beta	Homo sapiens	173-190
12510792-7	2002	In addition, Dodutang potently inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells.	dodutang	13-21	interleukin 1 beta	Homo sapiens	99-121
12485902-0	2002	Thalidomide suppresses the interleukin 1beta-induced NFkappaB signaling pathway in colon cancer cells.	Thalidomide	0-11	interleukin 1 beta	Homo sapiens	27-44
12485902-4	2002	Thalidomide inhibited interleukin (IL) 1beta-induced NFkappaB transcriptional activation and IL-8 production in Caco-2 colon cancer cells.	Thalidomide	0-11	interleukin 1 beta	Homo sapiens	22-44
12399442-5	2002	We had recently reported that the intracerebroventricular injection of IL-1beta, corticotropin-releasing factor, or beta-adrenergic agonists significantly interfered with the T response to human chorionic gonadotropin through mechanisms that did not involve LH.	Luteinizing Hormone	258-260	interleukin 1 beta	Homo sapiens	71-79
12510792-7	2002	In addition, Dodutang potently inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	125-156	interleukin 1 beta	Homo sapiens	99-121
12434136-5	2002	We found that IL-1beta significantly stimulated DNA synthesis (356.7% +/- 39% of control, P &lt;.003), fibronectin secretion (261.8 +/- 11% of control, P &lt;.005), collagen type 1 production, (release of procollagen type 1 C-terminal-peptide, 152.4% +/- 26% of control, P &lt;.005), transforming growth factor-beta (TGF-beta) secretion (211% +/- 37% of control, P &lt;.01), and nitric oxide (NO) production (342.8% +/- 69% of control, P &lt;.002).	Nitric Oxide	379-391	interleukin 1 beta	Homo sapiens	14-22
12510792-7	2002	In addition, Dodutang potently inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells.	Calcium	162-169	interleukin 1 beta	Homo sapiens	99-121
12413717-5	2002	GS-Tang (1 mg/ml) significantly inhibited the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), compared to absence of GS-Tang (by 42.0+/-6.6% inhibition for TNF-alpha and 95.9+/-5.7% for IL-1 beta, P&lt;0.05).	gs-tang	0-7	interleukin 1 beta	Homo sapiens	131-149
12413717-5	2002	GS-Tang (1 mg/ml) significantly inhibited the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), compared to absence of GS-Tang (by 42.0+/-6.6% inhibition for TNF-alpha and 95.9+/-5.7% for IL-1 beta, P&lt;0.05).	gs-tang	0-7	interleukin 1 beta	Homo sapiens	151-160
12413717-5	2002	GS-Tang (1 mg/ml) significantly inhibited the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), compared to absence of GS-Tang (by 42.0+/-6.6% inhibition for TNF-alpha and 95.9+/-5.7% for IL-1 beta, P&lt;0.05).	gs-tang	0-7	interleukin 1 beta	Homo sapiens	255-264
12391274-5	2002	These results suggest a role for PGE(2) in IL-1beta-induced mucin synthesis in NCI-H292 cells.	Prostaglandins E	33-36	interleukin 1 beta	Homo sapiens	43-51
12495545-17	2002	Accordingly, PGE(2) at sufficiently high plasma concentrations enhances cellular survival by inhibiting pro-inflammatory cytokines such as TNF-alpha and IL-1beta.	Prostaglandins E	13-16	interleukin 1 beta	Homo sapiens	153-161
12391274-7	2002	Cells activated by IL-1beta showed increased extracellular signal-regulated kinase (ERK)1/2 and p38 phosphorylation, and IL-1beta-induced MUC2 and MUC5AC production was blocked by the ERK pathway inhibitor PD98059 or the p38 inhibitor SB203580.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	206-213	interleukin 1 beta	Homo sapiens	19-27
12391274-7	2002	Cells activated by IL-1beta showed increased extracellular signal-regulated kinase (ERK)1/2 and p38 phosphorylation, and IL-1beta-induced MUC2 and MUC5AC production was blocked by the ERK pathway inhibitor PD98059 or the p38 inhibitor SB203580.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	206-213	interleukin 1 beta	Homo sapiens	121-129
12391274-7	2002	Cells activated by IL-1beta showed increased extracellular signal-regulated kinase (ERK)1/2 and p38 phosphorylation, and IL-1beta-induced MUC2 and MUC5AC production was blocked by the ERK pathway inhibitor PD98059 or the p38 inhibitor SB203580.	SB 203580	235-243	interleukin 1 beta	Homo sapiens	19-27
12391274-7	2002	Cells activated by IL-1beta showed increased extracellular signal-regulated kinase (ERK)1/2 and p38 phosphorylation, and IL-1beta-induced MUC2 and MUC5AC production was blocked by the ERK pathway inhibitor PD98059 or the p38 inhibitor SB203580.	SB 203580	235-243	interleukin 1 beta	Homo sapiens	121-129
12391274-8	2002	The inhibition of both MAPKs reduced IL-1beta-induced COX-2 expression and PGE(2) synthesis.	Dinoprostone	75-81	interleukin 1 beta	Homo sapiens	37-45
12391274-9	2002	Furthermore, the addition of PGE(2) to cells overcame the inhibitory effects of both MAPK inhibitors in IL-1beta-induced mucin production.	Prostaglandins E	29-32	interleukin 1 beta	Homo sapiens	104-112
12370394-6	2002	Human IL-10 was nitrated by incubation with peroxynitrite or by incubation with 3-morpholinosydnonimine, a peroxynitrite generator, for 2 h and then incubated with LPS-stimulated PBMC for 6 h, and IL-1 was measured in the culture supernatant fluids.	Peroxynitrous Acid	44-57	interleukin 1 beta	Homo sapiens	6-10
12435328-3	2002	The addition of 15d-PGJ(2) completely blocked (by 93%) the IL-1beta-induced PGE(2) synthesis, whereas COX-2 level was only partially reduced (by 72%).	15d-pgj	16-23	interleukin 1 beta	Homo sapiens	59-67
12435328-3	2002	The addition of 15d-PGJ(2) completely blocked (by 93%) the IL-1beta-induced PGE(2) synthesis, whereas COX-2 level was only partially reduced (by 72%).	Prostaglandins E	76-79	interleukin 1 beta	Homo sapiens	59-67
12370394-6	2002	Human IL-10 was nitrated by incubation with peroxynitrite or by incubation with 3-morpholinosydnonimine, a peroxynitrite generator, for 2 h and then incubated with LPS-stimulated PBMC for 6 h, and IL-1 was measured in the culture supernatant fluids.	Peroxynitrous Acid	107-120	interleukin 1 beta	Homo sapiens	6-10
12385002-0	2002	Retinoic acid induces expression of the interleukin-1beta gene in cultured normal human mammary epithelial cells and in human breast carcinoma lines.	Tretinoin	0-13	interleukin 1 beta	Homo sapiens	40-57
12385002-5	2002	Results from the treatment of HMEC with cycloheximide and actinomycin D indicated that the regulation of the IL-1beta gene by RA occurred at the transcriptional level and that the IL-1beta gene is a direct, downstream target gene of RA.	Cycloheximide	40-53	interleukin 1 beta	Homo sapiens	109-117
12385002-5	2002	Results from the treatment of HMEC with cycloheximide and actinomycin D indicated that the regulation of the IL-1beta gene by RA occurred at the transcriptional level and that the IL-1beta gene is a direct, downstream target gene of RA.	Cycloheximide	40-53	interleukin 1 beta	Homo sapiens	180-188
12385002-5	2002	Results from the treatment of HMEC with cycloheximide and actinomycin D indicated that the regulation of the IL-1beta gene by RA occurred at the transcriptional level and that the IL-1beta gene is a direct, downstream target gene of RA.	Dactinomycin	58-71	interleukin 1 beta	Homo sapiens	109-117
12374621-0	2002	Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes.	polyphenol epigallocatechin-3-gallate	10-47	interleukin 1 beta	Homo sapiens	61-70
12374621-2	2002	In the present study, we report the pharmacological effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), on interleukin-1 beta (IL-1 beta)-induced expression and activity of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in human chondrocytes derived from osteoarthritis (OA) cartilage.	polyphenol epigallocatechin-3-gallate	73-110	interleukin 1 beta	Homo sapiens	122-140
12370394-7	2002	Human IL-1 production was significantly lower in the peroxynitrite- or 3-morpholinosydnonimine-nitrated IL-10 group than in the IL-10 controls (p &lt; 0.05, all comparisons).	Peroxynitrous Acid	53-66	interleukin 1 beta	Homo sapiens	6-10
12370394-6	2002	Human IL-10 was nitrated by incubation with peroxynitrite or by incubation with 3-morpholinosydnonimine, a peroxynitrite generator, for 2 h and then incubated with LPS-stimulated PBMC for 6 h, and IL-1 was measured in the culture supernatant fluids.	linsidomine	80-103	interleukin 1 beta	Homo sapiens	6-10
12370394-7	2002	Human IL-1 production was significantly lower in the peroxynitrite- or 3-morpholinosydnonimine-nitrated IL-10 group than in the IL-10 controls (p &lt; 0.05, all comparisons).	linsidomine	71-94	interleukin 1 beta	Homo sapiens	6-10
12374621-2	2002	In the present study, we report the pharmacological effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), on interleukin-1 beta (IL-1 beta)-induced expression and activity of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in human chondrocytes derived from osteoarthritis (OA) cartilage.	polyphenol epigallocatechin-3-gallate	73-110	interleukin 1 beta	Homo sapiens	142-151
12374621-2	2002	In the present study, we report the pharmacological effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), on interleukin-1 beta (IL-1 beta)-induced expression and activity of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in human chondrocytes derived from osteoarthritis (OA) cartilage.	epigallocatechin gallate	112-116	interleukin 1 beta	Homo sapiens	122-140
12225948-3	2002	Bradykinin, transforming growth factor-beta1 (TGF-beta1), and interleukin-1beta (IL-1beta) increased inducible COX-2 expression and prostaglandin E(2) (PGE(2)) release.	Prostaglandins E	132-147	interleukin 1 beta	Homo sapiens	62-79
12374621-2	2002	In the present study, we report the pharmacological effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), on interleukin-1 beta (IL-1 beta)-induced expression and activity of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in human chondrocytes derived from osteoarthritis (OA) cartilage.	epigallocatechin gallate	112-116	interleukin 1 beta	Homo sapiens	142-151
12374621-3	2002	Stimulation of human chondrocytes with IL-1 beta (5 ng/ml) for 24 h resulted in significantly enhanced production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) when compared to untreated controls (p &lt;.001).	Nitric Oxide	117-129	interleukin 1 beta	Homo sapiens	39-48
12374621-3	2002	Stimulation of human chondrocytes with IL-1 beta (5 ng/ml) for 24 h resulted in significantly enhanced production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) when compared to untreated controls (p &lt;.001).	Dinoprostone	139-157	interleukin 1 beta	Homo sapiens	39-48
12374621-3	2002	Stimulation of human chondrocytes with IL-1 beta (5 ng/ml) for 24 h resulted in significantly enhanced production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) when compared to untreated controls (p &lt;.001).	Prostaglandins E	159-162	interleukin 1 beta	Homo sapiens	39-48
12374621-5	2002	In addition, IL-1 beta-induced expression of iNOS and COX-2 was also markedly inhibited in human chondrocytes pretreated with EGCG (p &lt;.001).	epigallocatechin gallate	126-130	interleukin 1 beta	Homo sapiens	13-22
12374621-6	2002	Parallel to these findings, EGCG also inhibited the IL-1 beta-induced LDH release in chondrocytes cultures.	epigallocatechin gallate	28-32	interleukin 1 beta	Homo sapiens	52-61
12374621-7	2002	Overall, the study suggests that EGCG affords protection against IL-1 beta-induced production of catabolic mediators NO and PGE(2) in human chondrocytes by regulating the expression and catalytic activity of their respective enzymes.	epigallocatechin gallate	33-37	interleukin 1 beta	Homo sapiens	65-74
12374621-7	2002	Overall, the study suggests that EGCG affords protection against IL-1 beta-induced production of catabolic mediators NO and PGE(2) in human chondrocytes by regulating the expression and catalytic activity of their respective enzymes.	Dinoprostone	124-130	interleukin 1 beta	Homo sapiens	65-74
12509942-5	2002	RESULTS: The levels of IL-6 and TNF-gamma in HMCL supernatants were dramatically increased when cultured HMCL were stimulated by IL-1beta (10 ng/ml).	hmcl	45-49	interleukin 1 beta	Homo sapiens	129-137
12509942-7	2002	However, PPARgamma agonist troglitazone down-regulated mRNA and protein expression of PPARgamma from IL-1beta challenge HMCLs.	Troglitazone	27-39	interleukin 1 beta	Homo sapiens	101-109
12509942-7	2002	However, PPARgamma agonist troglitazone down-regulated mRNA and protein expression of PPARgamma from IL-1beta challenge HMCLs.	hmcls	120-125	interleukin 1 beta	Homo sapiens	101-109
12509942-8	2002	PPARgamma agonists troglitazone, rosiglitazone, and 15-deoxy-Delta(12, 14)-prosglandin J(2) significantly decreased the upexpression of TNF-alpha and IL-6 in HMCL supernatants stimulated by IL-1beta.	Troglitazone	19-31	interleukin 1 beta	Homo sapiens	190-198
12509942-8	2002	PPARgamma agonists troglitazone, rosiglitazone, and 15-deoxy-Delta(12, 14)-prosglandin J(2) significantly decreased the upexpression of TNF-alpha and IL-6 in HMCL supernatants stimulated by IL-1beta.	Rosiglitazone	33-46	interleukin 1 beta	Homo sapiens	190-198
12440501-0	2002	Effects of dexamethasone on proteoglycan content and gene expression of IL-1beta-stimulated osteoarthrotic chondrocytes in vitro.	Dexamethasone	11-24	interleukin 1 beta	Homo sapiens	72-80
12440501-3	2002	Dexamethasone was added in three concentrations (10(-5), 10(-6), 10(-7) M) to IL-1beta (100 pg/nL)-stimulated chondrocytes.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	78-86
12440501-9	2002	The addition of dexamethasone to IL-1beta-stimulated chondrocytes further reduced the PG concentration by 19% at 10(-5) M and by 17% at 10(-7) M. The MMP-3 expression was inhibited between 27-53% and the AGG expression between 30-46% by dexamethasone.	Dexamethasone	16-29	interleukin 1 beta	Homo sapiens	33-41
12440501-9	2002	The addition of dexamethasone to IL-1beta-stimulated chondrocytes further reduced the PG concentration by 19% at 10(-5) M and by 17% at 10(-7) M. The MMP-3 expression was inhibited between 27-53% and the AGG expression between 30-46% by dexamethasone.	Dexamethasone	237-250	interleukin 1 beta	Homo sapiens	33-41
12225948-3	2002	Bradykinin, transforming growth factor-beta1 (TGF-beta1), and interleukin-1beta (IL-1beta) increased inducible COX-2 expression and prostaglandin E(2) (PGE(2)) release.	Prostaglandins E	132-147	interleukin 1 beta	Homo sapiens	81-89
12225948-3	2002	Bradykinin, transforming growth factor-beta1 (TGF-beta1), and interleukin-1beta (IL-1beta) increased inducible COX-2 expression and prostaglandin E(2) (PGE(2)) release.	Prostaglandins E	152-155	interleukin 1 beta	Homo sapiens	62-79
12225948-3	2002	Bradykinin, transforming growth factor-beta1 (TGF-beta1), and interleukin-1beta (IL-1beta) increased inducible COX-2 expression and prostaglandin E(2) (PGE(2)) release.	Prostaglandins E	152-155	interleukin 1 beta	Homo sapiens	81-89
12234873-1	2002	The antibiotic telithromycin was examined for its effect on secretion of interleukin-1alpha (IL-1alpha), IL-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide (LPS)-stimulated monocytes of eight human donors.	telithromycin	15-28	interleukin 1 beta	Homo sapiens	105-113
12371761-11	2002	CONCLUSIONS AND CLINICAL RELEVANCE: Human recombinant IL-1beta resulted in loss of cell viability, alterations in extracellular matrix components, and production of PG and MMP Carprofen and dexamethasone had little effect on cell and matrix variables but did decrease PGE2 concentrations and primarily affected the inflammatory pathway of osteoarthritis.	pg	165-167	interleukin 1 beta	Homo sapiens	54-62
12371761-11	2002	CONCLUSIONS AND CLINICAL RELEVANCE: Human recombinant IL-1beta resulted in loss of cell viability, alterations in extracellular matrix components, and production of PG and MMP Carprofen and dexamethasone had little effect on cell and matrix variables but did decrease PGE2 concentrations and primarily affected the inflammatory pathway of osteoarthritis.	carprofen	176-185	interleukin 1 beta	Homo sapiens	54-62
12371761-11	2002	CONCLUSIONS AND CLINICAL RELEVANCE: Human recombinant IL-1beta resulted in loss of cell viability, alterations in extracellular matrix components, and production of PG and MMP Carprofen and dexamethasone had little effect on cell and matrix variables but did decrease PGE2 concentrations and primarily affected the inflammatory pathway of osteoarthritis.	Dexamethasone	190-203	interleukin 1 beta	Homo sapiens	54-62
12371761-11	2002	CONCLUSIONS AND CLINICAL RELEVANCE: Human recombinant IL-1beta resulted in loss of cell viability, alterations in extracellular matrix components, and production of PG and MMP Carprofen and dexamethasone had little effect on cell and matrix variables but did decrease PGE2 concentrations and primarily affected the inflammatory pathway of osteoarthritis.	Dinoprostone	268-272	interleukin 1 beta	Homo sapiens	54-62
12241537-7	2002	These effects of IL-1beta were inhibited by treatment of the cells with sodium arsenite in a dose- and time-dependent fashion.	sodium arsenite	72-87	interleukin 1 beta	Homo sapiens	17-25
12384940-0	2002	Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome.	Terpenes	8-18	interleukin 1 beta	Homo sapiens	43-60
12384940-6	2002	RESULTS: Lovastatin induced a 15-fold rise in IL-1beta secretion by normal anti-CD2 + CD28-stimulated cells (P &lt; 0.001).	Lovastatin	9-19	interleukin 1 beta	Homo sapiens	46-54
12384940-10	2002	The effect of lovastatin on IL-1beta secretion was reduced by mevalonate, FOH, and GGOH.	Lovastatin	14-24	interleukin 1 beta	Homo sapiens	28-36
12384940-10	2002	The effect of lovastatin on IL-1beta secretion was reduced by mevalonate, FOH, and GGOH.	Mevalonic Acid	62-72	interleukin 1 beta	Homo sapiens	28-36
12384940-10	2002	The effect of lovastatin on IL-1beta secretion was reduced by mevalonate, FOH, and GGOH.	foh	74-77	interleukin 1 beta	Homo sapiens	28-36
12384940-10	2002	The effect of lovastatin on IL-1beta secretion was reduced by mevalonate, FOH, and GGOH.	ggoh	83-87	interleukin 1 beta	Homo sapiens	28-36
12384940-12	2002	Bypassing this defect with FOH, in the absence of lovastatin, led to a 62% reduction (P &lt; 0.02) in IL-1beta secretion by these cells.	foh	27-30	interleukin 1 beta	Homo sapiens	102-110
12384940-13	2002	CONCLUSION: In this model, shortage of isoprenoid end products contributes to increased IL-1beta secretion by MK-deficient PBMCs, whereas excess mevalonate does not.	Terpenes	39-49	interleukin 1 beta	Homo sapiens	88-96
12231511-5	2002	However, in keeping with their respective role of early and late inflammatory factors, IL-1beta and HMGB1 respond at different times to different stimuli: IL-1beta secretion is induced earlier by ATP, autocrinally released by monocytes soon after activation; HMGB1 secretion is triggered by lysophosphatidylcholine, generated later in the inflammation site.	Adenosine Triphosphate	196-199	interleukin 1 beta	Homo sapiens	87-95
12377625-6	2002	A positive correlation was observed between the sera concentrations of IL-1beta and estradiol on the day when human chorionic gonadotrophin (hCG) was injected (r=0.92, P&lt;0.001), while on the same day the concentration of IL-1beta was shown to be inversely correlated with progesterone levels (r=-0.34, P&lt;0.05).	Progesterone	275-287	interleukin 1 beta	Homo sapiens	71-79
12231511-5	2002	However, in keeping with their respective role of early and late inflammatory factors, IL-1beta and HMGB1 respond at different times to different stimuli: IL-1beta secretion is induced earlier by ATP, autocrinally released by monocytes soon after activation; HMGB1 secretion is triggered by lysophosphatidylcholine, generated later in the inflammation site.	Adenosine Triphosphate	196-199	interleukin 1 beta	Homo sapiens	155-163
12231511-5	2002	However, in keeping with their respective role of early and late inflammatory factors, IL-1beta and HMGB1 respond at different times to different stimuli: IL-1beta secretion is induced earlier by ATP, autocrinally released by monocytes soon after activation; HMGB1 secretion is triggered by lysophosphatidylcholine, generated later in the inflammation site.	Lysophosphatidylcholines	291-314	interleukin 1 beta	Homo sapiens	87-95
12231511-5	2002	However, in keeping with their respective role of early and late inflammatory factors, IL-1beta and HMGB1 respond at different times to different stimuli: IL-1beta secretion is induced earlier by ATP, autocrinally released by monocytes soon after activation; HMGB1 secretion is triggered by lysophosphatidylcholine, generated later in the inflammation site.	Lysophosphatidylcholines	291-314	interleukin 1 beta	Homo sapiens	155-163
12239595-6	2002	IL-1beta production of PBMC stimulated by ET or ET+MDP in patients on hemodialysis using a polysulfon (PS) membrane was significantly lower than those using a cuprammonium-rayon (CU) membrane, ethylenevinylalcohol (EVAL) membrane, polymethylmetacrylate (PMMA) membrane, respectively.	PBMC	23-27	interleukin 1 beta	Homo sapiens	0-8
12231210-2	2002	The aim of this study was to investigate the effects of sulfasalazine (SASP) and its metabolites, sulfapyridine (SP), and 5-aminosalicylic acid (5ASA) on chemokine production by RA synovial tissue explants and interleukin (IL)-1beta-stimulated RA synovial tissue fibroblasts using enzyme-linked immunosorbent assays and flow cytometry.	Sulfasalazine	56-69	interleukin 1 beta	Homo sapiens	210-232
12231210-6	2002	In IL-1beta-stimulated RA synovial tissue fibroblasts, SASP significantly increased chemokine secretion, while SP significantly decreased IL-8 (24%) and GROalpha (21%) secretion (P &lt; 0.05).	Sulfapyridine	57-59	interleukin 1 beta	Homo sapiens	3-11
12239595-6	2002	IL-1beta production of PBMC stimulated by ET or ET+MDP in patients on hemodialysis using a polysulfon (PS) membrane was significantly lower than those using a cuprammonium-rayon (CU) membrane, ethylenevinylalcohol (EVAL) membrane, polymethylmetacrylate (PMMA) membrane, respectively.	et+mdp	48-54	interleukin 1 beta	Homo sapiens	0-8
12239595-6	2002	IL-1beta production of PBMC stimulated by ET or ET+MDP in patients on hemodialysis using a polysulfon (PS) membrane was significantly lower than those using a cuprammonium-rayon (CU) membrane, ethylenevinylalcohol (EVAL) membrane, polymethylmetacrylate (PMMA) membrane, respectively.	polysulfon	91-101	interleukin 1 beta	Homo sapiens	0-8
12239595-6	2002	IL-1beta production of PBMC stimulated by ET or ET+MDP in patients on hemodialysis using a polysulfon (PS) membrane was significantly lower than those using a cuprammonium-rayon (CU) membrane, ethylenevinylalcohol (EVAL) membrane, polymethylmetacrylate (PMMA) membrane, respectively.	ps	103-105	interleukin 1 beta	Homo sapiens	0-8
12433058-2	2002	Inhibition of glutathione-oxidized disulfide reductase, which recycles GSSG --&gt; 2GSH, by the action of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) augmented LPS-dependent secretion of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha.	Glutathione	14-25	interleukin 1 beta	Homo sapiens	188-210
12433058-2	2002	Inhibition of glutathione-oxidized disulfide reductase, which recycles GSSG --&gt; 2GSH, by the action of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) augmented LPS-dependent secretion of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha.	Glutathione Disulfide	71-78	interleukin 1 beta	Homo sapiens	188-210
12239595-6	2002	IL-1beta production of PBMC stimulated by ET or ET+MDP in patients on hemodialysis using a polysulfon (PS) membrane was significantly lower than those using a cuprammonium-rayon (CU) membrane, ethylenevinylalcohol (EVAL) membrane, polymethylmetacrylate (PMMA) membrane, respectively.	eval	215-219	interleukin 1 beta	Homo sapiens	0-8
12433058-2	2002	Inhibition of glutathione-oxidized disulfide reductase, which recycles GSSG --&gt; 2GSH, by the action of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) augmented LPS-dependent secretion of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha.	Carmustine	106-143	interleukin 1 beta	Homo sapiens	188-210
12433058-4	2002	Inhibition of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the biosynthesis of GSH, by the action of L-buthionine-(S,R)-sulfoximine (BSO), potentiated LPS-induced IL-1beta, IL-6 and TNF-alpha production.	l-buthionine sulfoximine	119-149	interleukin 1 beta	Homo sapiens	181-189
12433058-4	2002	Inhibition of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the biosynthesis of GSH, by the action of L-buthionine-(S,R)-sulfoximine (BSO), potentiated LPS-induced IL-1beta, IL-6 and TNF-alpha production.	Buthionine Sulfoximine	151-154	interleukin 1 beta	Homo sapiens	181-189
12239595-6	2002	IL-1beta production of PBMC stimulated by ET or ET+MDP in patients on hemodialysis using a polysulfon (PS) membrane was significantly lower than those using a cuprammonium-rayon (CU) membrane, ethylenevinylalcohol (EVAL) membrane, polymethylmetacrylate (PMMA) membrane, respectively.	Polymethyl Methacrylate	231-252	interleukin 1 beta	Homo sapiens	0-8
12239595-6	2002	IL-1beta production of PBMC stimulated by ET or ET+MDP in patients on hemodialysis using a polysulfon (PS) membrane was significantly lower than those using a cuprammonium-rayon (CU) membrane, ethylenevinylalcohol (EVAL) membrane, polymethylmetacrylate (PMMA) membrane, respectively.	Polymethyl Methacrylate	254-258	interleukin 1 beta	Homo sapiens	0-8
12674935-10	2002	The effect of the two recombinant cytokines (IL-1 beta, IFN-gamma) on the character of free radical production and intracellular killing of Staphylococci by neutrophils isolated from the blood of patients and healthy donors has been studied.	Free Radicals	87-99	interleukin 1 beta	Homo sapiens	45-54
12379770-3	2002	This study aimed to investigate whether cerulein induced ROS generation, lipid peroxide and hydrogen peroxide production, NF-kappaB activation, and expression of cytokines (IL-1beta, IL-6) in pancreatic acinar cells.	Ceruletide	40-48	interleukin 1 beta	Homo sapiens	173-181
12384172-0	2002	Nitric oxide synergistically potentiates interleukin-1 beta-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	41-59
12384172-0	2002	Nitric oxide synergistically potentiates interleukin-1 beta-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms.	Cyclic GMP	209-213	interleukin 1 beta	Homo sapiens	41-59
12384172-5	2002	Similarly, while SNAP did not elicit the expression of COX-2 mRNA, it potentiated the expression induced by IL-1 beta in cultured DRG cells, and this potentiation was significantly suppressed by the NO scavenger, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (carboxy-PTIO).	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	213-278	interleukin 1 beta	Homo sapiens	108-117
12384172-7	2002	The stimulatory effect of SNAP on the IL-1 beta-induced release of SP was completely inhibited on co-incubation with a selective COX-2 inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	146-152	interleukin 1 beta	Homo sapiens	38-47
12384172-9	2002	These results suggest that in cultured DRG cells, NO potentiates the IL-1 beta-induced increase in COX-2 expression via a soluble guanylate cyclase-cGMP-independent pathway, resulting in facilitation of SP release.	Cyclic GMP	148-152	interleukin 1 beta	Homo sapiens	69-78
12210475-5	2002	RESULTS: In LNCaP treated with testosterone before IL-1 beta stimulation induced promatrilysin expression was completely abrogated.	Testosterone	31-43	interleukin 1 beta	Homo sapiens	51-60
12210475-9	2002	CONCLUSION: From these data, we conclude that testosterone blocks IL-1 beta-induced promatrilysin expression by inhibition of NF kappa B transactivation activity, which in turn, blocks IL-6 expression.	Testosterone	46-58	interleukin 1 beta	Homo sapiens	66-75
12107182-1	2002	The binding of extracellular ATP to the P2X(7) receptor opens an integral cation-permeable channel; it also leads to membrane blebbing and, in certain immune cells, interleukin-1beta secretion and eventual death.	Adenosine Triphosphate	29-32	interleukin 1 beta	Homo sapiens	165-182
12353854-5	2002	IL-1beta was higher in the small intestine of the short-chain fatty acid group (P &lt; 0.05).	Fatty Acids, Volatile	50-72	interleukin 1 beta	Homo sapiens	0-8
12215492-6	2002	On the other hand, PPAR-gamma ligands troglitazone, pioglitazone, and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited IL-1beta-induced IL-6 expression at a transcriptional revel in VSMCs.	Troglitazone	38-50	interleukin 1 beta	Homo sapiens	121-129
12215492-6	2002	On the other hand, PPAR-gamma ligands troglitazone, pioglitazone, and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited IL-1beta-induced IL-6 expression at a transcriptional revel in VSMCs.	Pioglitazone	52-64	interleukin 1 beta	Homo sapiens	121-129
12215492-6	2002	On the other hand, PPAR-gamma ligands troglitazone, pioglitazone, and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited IL-1beta-induced IL-6 expression at a transcriptional revel in VSMCs.	delta	79-84	interleukin 1 beta	Homo sapiens	121-129
12215492-6	2002	On the other hand, PPAR-gamma ligands troglitazone, pioglitazone, and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibited IL-1beta-induced IL-6 expression at a transcriptional revel in VSMCs.	prostaglandin j	92-107	interleukin 1 beta	Homo sapiens	121-129
12381952-6	2002	In 2 of 10 experiments pro-IL-1beta was detected in monocytes interacting with Cu, PS and AN69S membrane.	cuprammonium cellulose	79-81	interleukin 1 beta	Homo sapiens	27-35
12230110-3	2002	In this report, the effects of polychlorinated biphenyl (PCB) on the expression of cyclooxygenase-2 and pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor (TNF)-alpha in the human leukemic mast cell line were investigated.	Polychlorinated Biphenyls	31-55	interleukin 1 beta	Homo sapiens	139-156
12230110-3	2002	In this report, the effects of polychlorinated biphenyl (PCB) on the expression of cyclooxygenase-2 and pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor (TNF)-alpha in the human leukemic mast cell line were investigated.	Polychlorinated Biphenyls	31-55	interleukin 1 beta	Homo sapiens	158-166
12230110-3	2002	In this report, the effects of polychlorinated biphenyl (PCB) on the expression of cyclooxygenase-2 and pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor (TNF)-alpha in the human leukemic mast cell line were investigated.	Polychlorinated Biphenyls	57-60	interleukin 1 beta	Homo sapiens	139-156
12230110-3	2002	In this report, the effects of polychlorinated biphenyl (PCB) on the expression of cyclooxygenase-2 and pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor (TNF)-alpha in the human leukemic mast cell line were investigated.	Polychlorinated Biphenyls	57-60	interleukin 1 beta	Homo sapiens	158-166
12230110-4	2002	TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB.	Polychlorinated Biphenyls	169-172	interleukin 1 beta	Homo sapiens	14-22
12230110-4	2002	TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB.	Polychlorinated Biphenyls	169-172	interleukin 1 beta	Homo sapiens	324-332
12230110-4	2002	TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB.	Polychlorinated Biphenyls	169-172	interleukin 1 beta	Homo sapiens	14-22
12230110-4	2002	TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB.	Polychlorinated Biphenyls	169-172	interleukin 1 beta	Homo sapiens	324-332
12412198-8	2002	RESULTS: IL-1 beta decreased the accumulation of aggrecan, hyaluronan and type II collagen in the CAM and increased intracellular MMP-1, -3 and -13 at a concentration of 100 pg/ml.	Hyaluronic Acid	59-69	interleukin 1 beta	Homo sapiens	9-18
12412198-9	2002	Xylosan polysulphate and chrondroitin polysulphate restored the expression of these CAM molecules in these IL-1 beta-treated cultures.	xylosan polysulphate	0-20	interleukin 1 beta	Homo sapiens	107-116
12412198-9	2002	Xylosan polysulphate and chrondroitin polysulphate restored the expression of these CAM molecules in these IL-1 beta-treated cultures.	chrondroitin polysulphate	25-50	interleukin 1 beta	Homo sapiens	107-116
12412198-10	2002	Hydrocortisone stimulated the accumulation of CAM aggrecan and hyaluronan whether or not under the exposure to IL-1 beta.	Hydrocortisone	0-14	interleukin 1 beta	Homo sapiens	111-120
12412198-11	2002	Intracellular MMP-1, -3, -13 and TIMP-1 and -3 of IL-1 beta-treated cells was downregulated after treatment with hydrocortisone.	Hydrocortisone	113-127	interleukin 1 beta	Homo sapiens	50-59
12412198-12	2002	CONCLUSION: Both hydrocortisone and the two polysulphated polysaccharides could stimulate the accumulation of CAM macromolecules of IL-1 beta-treated chondrocytes.	Hydrocortisone	17-31	interleukin 1 beta	Homo sapiens	132-141
12412198-12	2002	CONCLUSION: Both hydrocortisone and the two polysulphated polysaccharides could stimulate the accumulation of CAM macromolecules of IL-1 beta-treated chondrocytes.	Polysaccharides	58-73	interleukin 1 beta	Homo sapiens	132-141
12412198-12	2002	CONCLUSION: Both hydrocortisone and the two polysulphated polysaccharides could stimulate the accumulation of CAM macromolecules of IL-1 beta-treated chondrocytes.	cafestol palmitate	110-113	interleukin 1 beta	Homo sapiens	132-141
12351936-11	2002	Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4.	Nitrites	13-20	interleukin 1 beta	Homo sapiens	91-99
12381952-6	2002	In 2 of 10 experiments pro-IL-1beta was detected in monocytes interacting with Cu, PS and AN69S membrane.	polysulfone P 1700	83-85	interleukin 1 beta	Homo sapiens	27-35
12381952-9	2002	More specifically, synthetic membranes (both polyacrylonitrile and PS) were found to be as active as Cu in inducing IL-1beta and TNF-alpha mRNA expression, but less effective in promoting the extracellular release of proinflammatory cytokine products.	polyacrylonitrile	45-62	interleukin 1 beta	Homo sapiens	116-124
12381952-9	2002	More specifically, synthetic membranes (both polyacrylonitrile and PS) were found to be as active as Cu in inducing IL-1beta and TNF-alpha mRNA expression, but less effective in promoting the extracellular release of proinflammatory cytokine products.	polysulfone P 1700	67-69	interleukin 1 beta	Homo sapiens	116-124
12355482-8	2002	All sections that were highly positive for IL-1beta also showed staining for nitrotyrosine.	3-nitrotyrosine	77-90	interleukin 1 beta	Homo sapiens	43-51
12353854-8	2002	These results indicate short-chain fatty acids beneficially increase small intestinal abundance of IL-1beta and IL-6 during total parenteral nutrition administration, while not affecting systemic production of these cytokines or intestinal inflammation.	Fatty Acids, Volatile	23-46	interleukin 1 beta	Homo sapiens	99-107
12171950-11	2002	Pulsatile exposure of BE to acid and bile, as well as juxtaposition of BE to squamous epithelial cells in culture, increased expression of IL-1 beta.	Beryllium	22-24	interleukin 1 beta	Homo sapiens	139-148
12370131-3	2002	In this study, we investigated the influence of various steroid hormones on the IL-1beta (50 U/mL)/TNF-alpha (50 U/mL) stimulated human dermal microvascular endothelial cell line (HMEC-1) and human umbilical vein endothelial cells (HUVEC).	Steroids	56-63	interleukin 1 beta	Homo sapiens	80-88
12233875-9	2002	Conversion of PGH2 to PGE2 increased by IL-1beta and was correlated with mPGES expression.	Prostaglandin H2	14-18	interleukin 1 beta	Homo sapiens	40-48
12356282-1	2002	We examined the inhibitory mechanism of byakangelicol, isolated from Angelica dahurica, on interleukin-1beta (IL-1beta)-induced cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) release in human pulmonary epithelial cell line (A549).	Dinoprostone	186-190	interleukin 1 beta	Homo sapiens	110-118
12356282-2	2002	Byakangelicol (10-50 microM) concentration-dependently attenuated IL-1beta-induced COX-2 expression and PGE2 release.	byakangelicol	0-13	interleukin 1 beta	Homo sapiens	66-74
12403398-10	2002	Steam sterilization of SMC induced a lower spontaneous IL-1beta release, but this effect was not statistically significant due to the large inter-individual variation.	S-Methyl-L-cysteine	23-26	interleukin 1 beta	Homo sapiens	55-63
12235117-0	2002	Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.	Glucose	0-7	interleukin 1 beta	Homo sapiens	40-48
12235117-5	2002	The aim of the present study was to test the hypothesis that IL-1beta may mediate the deleterious effects of high glucose on human beta cells.	Glucose	114-121	interleukin 1 beta	Homo sapiens	61-69
12235117-6	2002	In vitro exposure of islets from nondiabetic organ donors to high glucose levels resulted in increased production and release of IL-1beta, followed by NF-kappaB activation, Fas upregulation, DNA fragmentation, and impaired beta cell function.	Glucose	66-73	interleukin 1 beta	Homo sapiens	129-137
12235117-8	2002	beta cells themselves were identified as the islet cellular source of glucose-induced IL-1beta.	Glucose	70-77	interleukin 1 beta	Homo sapiens	86-94
12235117-11	2002	Treatment of the animals with phlorizin normalized plasma glucose and prevented beta cell expression of IL-1beta.	Phlorhizin	30-39	interleukin 1 beta	Homo sapiens	104-112
12356282-2	2002	Byakangelicol (10-50 microM) concentration-dependently attenuated IL-1beta-induced COX-2 expression and PGE2 release.	Dinoprostone	104-108	interleukin 1 beta	Homo sapiens	66-74
12356282-5	2002	IL-1beta-induced p44/42 mitogen-activated protein kinase (MAPK) activation was inhibited by the MAPK/extracellular signal-regulated protein kinase (MEK) inhibitor, PD 98059 (30 microM), while byakangelicol (50 microM) had no effect.	byakangelicol	192-205	interleukin 1 beta	Homo sapiens	0-8
12233875-9	2002	Conversion of PGH2 to PGE2 increased by IL-1beta and was correlated with mPGES expression.	Dinoprostone	22-26	interleukin 1 beta	Homo sapiens	40-48
12356282-6	2002	Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation.	byakangelicol	24-37	interleukin 1 beta	Homo sapiens	119-127
12233875-12	2002	Dexamethasone inhibited mRNA and protein expression for mPGES and increased conversion of arachidonic acid to PGE2, but inhibition of mPGES was weaker compared with that of COX-2 in IL-1beta stimulated cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	182-190
12356282-6	2002	Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation.	pyrrolidine dithiocarbamic acid	53-80	interleukin 1 beta	Homo sapiens	119-127
12356282-6	2002	Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation.	pyrrolidine dithiocarbamic acid	82-86	interleukin 1 beta	Homo sapiens	119-127
12233876-2	2002	METHODS: Using molecular analyses of AR in combination with the multiprobe ribonuclease protection assay and ELISA, we investigated the presence of AR and the effect of DHT on interleukin 1beta (IL-1beta) induced expression of the IL-6 superfamily of cytokines in synoviocytes.	Dihydrotestosterone	169-172	interleukin 1 beta	Homo sapiens	176-193
12356282-7	2002	Taken together, we have demonstrated that byakangelicol inhibits IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expression and the activity of COX-2 enzyme.	byakangelicol	42-55	interleukin 1 beta	Homo sapiens	65-73
12356282-7	2002	Taken together, we have demonstrated that byakangelicol inhibits IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expression and the activity of COX-2 enzyme.	Dinoprostone	82-86	interleukin 1 beta	Homo sapiens	65-73
12233876-2	2002	METHODS: Using molecular analyses of AR in combination with the multiprobe ribonuclease protection assay and ELISA, we investigated the presence of AR and the effect of DHT on interleukin 1beta (IL-1beta) induced expression of the IL-6 superfamily of cytokines in synoviocytes.	Dihydrotestosterone	169-172	interleukin 1 beta	Homo sapiens	195-203
12233876-4	2002	DHT exerts a suppressive effect on IL-1beta induced IL-6, macrophage-colony stimulating factor (CSF), and granulocyte-CSF production by synoviocytes.	Dihydrotestosterone	0-3	interleukin 1 beta	Homo sapiens	35-43
12193665-0	2002	COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells.	Prostaglandins	64-74	interleukin 1 beta	Homo sapiens	43-52
12181421-3	2002	We studied the effect of an inosine-5"-monophosphate dehydrogenase (IMPDH) inhibitor, mycophenolic acid (MPA), on constitutive and IL-1beta-induced expression of ICAM-1 in human umbilical vein endothelial cells (HUVECs).	Mycophenolic Acid	86-103	interleukin 1 beta	Homo sapiens	131-139
12181421-3	2002	We studied the effect of an inosine-5"-monophosphate dehydrogenase (IMPDH) inhibitor, mycophenolic acid (MPA), on constitutive and IL-1beta-induced expression of ICAM-1 in human umbilical vein endothelial cells (HUVECs).	Mycophenolic Acid	105-108	interleukin 1 beta	Homo sapiens	131-139
12181421-7	2002	The up-regulation of ICAM-1 by MPA was prevented by high doses (100 microM) of guanine or guanosine but not by physiological doses (0.1 microM), indicating that guanylates are involved in endothelial responses to IL-1beta.	Guanine	79-86	interleukin 1 beta	Homo sapiens	213-221
12193665-5	2002	Basal and IL-1 beta-stimulated COX activities were inhibited by NS-398, indicating substantial COX-2 contribution to endothelial prostanoid synthesis in neonatal human brain cortex and cerebellum at rest and when mimicking the inflammatory conditions.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	64-70	interleukin 1 beta	Homo sapiens	10-19
12193665-5	2002	Basal and IL-1 beta-stimulated COX activities were inhibited by NS-398, indicating substantial COX-2 contribution to endothelial prostanoid synthesis in neonatal human brain cortex and cerebellum at rest and when mimicking the inflammatory conditions.	Prostaglandins	129-139	interleukin 1 beta	Homo sapiens	10-19
12193665-7	2002	In IL-1 beta-treated hCMVEC, a shift toward PGE(2) as the major vasodilator product of the COX pathway was observed.	Prostaglandins E	44-47	interleukin 1 beta	Homo sapiens	3-12
12193665-8	2002	Acute treatment with the protein tyrosine kinase inhibitor, tyrphostin 25, inhibited basal and IL-1 beta-induced COX activities, suggesting the importance of posttranslational modifications in endothelial COX-2 activation in human brain.	Tyrphostins	60-70	interleukin 1 beta	Homo sapiens	95-104
12193665-9	2002	Altogether, these data indicate that both COX-1 and COX-2 contribute to endothelial prostanoid synthesis in the neonatal human brain under basal conditions and in response to proinflammatory cytokine IL-1 beta.	Prostaglandins	84-94	interleukin 1 beta	Homo sapiens	200-209
12221458-11	2002	Concentrations of interleukin 1 beta and thromboxane B(2) in the perfusate were significantly higher in NHB group, but they were completely suppressed in the KE group.	nhb	104-107	interleukin 1 beta	Homo sapiens	18-36
12183434-9	2002	TNF-alpha and IL-1beta act by inhibiting the IGF-I receptor from tyrosine phosphorylating insulin receptor substrate-1 without affecting tyrosine kinase activity of the IGF-IR itself.	Tyrosine	65-73	interleukin 1 beta	Homo sapiens	14-22
12105223-7	2002	Curcumin, but not PD98059 or SB203580, inhibited IL-1 beta-mediated suppression of nuclear RXR:RAR binding activity, which correlated with inhibition of JNK phosphorylation and phospho-JNK-mediated phosphorylation of RXR.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	49-58
12050157-6	2002	These findings indicate a novel [IL-1beta+Abeta42]-mediated, hypoxia-enhanced, free radical-triggered gene program that drives inflammatory gene signaling and suggest a mechanism by which hypoxia during aging contributes episodically to amyloidogenesis, inflammation, and AD pathophysiology.	Free Radicals	79-91	interleukin 1 beta	Homo sapiens	33-41
12167775-2	2002	We report that 17beta-estradiol (E(2)), but not the alpha-enantiomer, inhibited the basal and interleukin-1beta (IL-1beta)-mediated expression of the intercellular adhesion molecule type 1 (ICAM1) and NFkappaB activation, in cultured brain endothelial cells.	Estradiol	15-31	interleukin 1 beta	Homo sapiens	94-111
12177784-8	2002	An inhibitor of extracellular signal-related kinase pathway signalling (U0126) blocked induction of matrix metalloproteinase-1 production induced by keratinocyte-conditioned medium (as well as by epidermal growth factor or interleukin-1beta), and also inhibited proliferation.	U 0126	72-77	interleukin 1 beta	Homo sapiens	223-240
12177784-9	2002	A p38 signalling inhibitor (SB203580) blocked matrix metalloproteinase-1 elaboration induced by keratinocyte-conditioned medium or interleukin-1beta, but did not inhibit matrix metalloproteinase-1 elaboration or cell growth induced by epidermal growth factor.	SB 203580	28-36	interleukin 1 beta	Homo sapiens	131-148
12147222-6	2002	The above effect of PDMP, KB-R8301, and C2-ceramide in HUVECs was commonly found in unstimulated, TNF-alpha-stimulated, and IL-1beta-stimulated HUVECs.	RV 538	20-24	interleukin 1 beta	Homo sapiens	124-132
12147222-6	2002	The above effect of PDMP, KB-R8301, and C2-ceramide in HUVECs was commonly found in unstimulated, TNF-alpha-stimulated, and IL-1beta-stimulated HUVECs.	KB R8301	26-34	interleukin 1 beta	Homo sapiens	124-132
12167775-2	2002	We report that 17beta-estradiol (E(2)), but not the alpha-enantiomer, inhibited the basal and interleukin-1beta (IL-1beta)-mediated expression of the intercellular adhesion molecule type 1 (ICAM1) and NFkappaB activation, in cultured brain endothelial cells.	Estradiol	15-31	interleukin 1 beta	Homo sapiens	113-121
12147222-6	2002	The above effect of PDMP, KB-R8301, and C2-ceramide in HUVECs was commonly found in unstimulated, TNF-alpha-stimulated, and IL-1beta-stimulated HUVECs.	N-acetylsphingosine	40-51	interleukin 1 beta	Homo sapiens	124-132
12107048-7	2002	NHE inhibition decreased also the IL-1beta-induced HUVEC inflammatory response, because amiloride suppressed IL-1beta-induced E-selectin expression on HUVECs.	Amiloride	88-97	interleukin 1 beta	Homo sapiens	109-117
12209512-0	2002	Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB.	epigallocatechin gallate	0-26	interleukin 1 beta	Homo sapiens	36-53
12209512-0	2002	Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB.	Nitric Oxide	76-88	interleukin 1 beta	Homo sapiens	36-53
12209512-1	2002	OBJECTIVE: The proinflammatory cytokine interleukin-1beta (IL-1beta) induces the production of high levels of nitric oxide (NO) in human chondrocytes.	Nitric Oxide	110-122	interleukin 1 beta	Homo sapiens	40-57
12209512-1	2002	OBJECTIVE: The proinflammatory cytokine interleukin-1beta (IL-1beta) induces the production of high levels of nitric oxide (NO) in human chondrocytes.	Nitric Oxide	110-122	interleukin 1 beta	Homo sapiens	59-67
12209512-3	2002	In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on IL-1beta-induced production of NO in primary human osteoarthritis (OA) chondrocytes.	epigallocatechin gallate	48-74	interleukin 1 beta	Homo sapiens	110-118
12209512-3	2002	In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on IL-1beta-induced production of NO in primary human osteoarthritis (OA) chondrocytes.	epigallocatechin gallate	76-80	interleukin 1 beta	Homo sapiens	110-118
12209512-3	2002	In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on IL-1beta-induced production of NO in primary human osteoarthritis (OA) chondrocytes.	Polyphenols	95-105	interleukin 1 beta	Homo sapiens	110-118
12145100-9	2002	However, SB 203580, a p38 MAPK inhibitor, suppressed PGHS-2 induction by IL-1beta alone or combined with TNF-alpha, demonstrating that p38 MAPK but not p42/44 MAPK or JNK cascades are required for PGHS-2 up-regulation.	SB 203580	9-18	interleukin 1 beta	Homo sapiens	73-81
12209512-11	2002	CONCLUSION: Our results indicate that EGCG inhibits the IL-1beta-induced production of NO in human chondrocytes by interfering with the activation of NF-kappaB through a novel mechanism.	epigallocatechin gallate	38-42	interleukin 1 beta	Homo sapiens	56-64
12209512-12	2002	Our data further suggest that EGCG may be a therapeutically effective inhibitor of IL-1beta-induced inflammatory effects that are dependent on NF-kappaB activation in human OA chondrocytes.	epigallocatechin gallate	30-34	interleukin 1 beta	Homo sapiens	83-91
12165097-6	2002	Electrophoretic mobility shift assay (EMSA) showed a significant reduction in the DNA binding activity of NF-kappaB in troglitazone-treated FLS in response to TNF-alpha or IL-1beta.	Troglitazone	119-131	interleukin 1 beta	Homo sapiens	172-180
12361727-7	2002	After 6 days of preincubation, all three stimuli increased progesterone production, and this preincubation period was used in the remainder of the study.LH and IL-1beta increased the intracellular levels of 5,6-epoxyeicosatrienoic acid (5,6-EpETrE) maximally after 10 min, whereas db.	Progesterone	59-71	interleukin 1 beta	Homo sapiens	160-168
12228766-0	2002	Captopril-impaired production of tumor necrosis factor-alpha-induced interleukin-1beta in human monocytes is associated with altered intracellular distribution of nuclear factor-kappaB.	Captopril	0-9	interleukin 1 beta	Homo sapiens	69-86
12228766-1	2002	We evaluated the effects of the angiotensin-converting enzyme (ACE) inhibitor captopril on pathways for monocyte production of interleukin (IL)-1beta in vitro.	Captopril	78-87	interleukin 1 beta	Homo sapiens	127-149
12228766-3	2002	Captopril caused a dose-dependent reduction of TNF-alpha induced IL-1beta.	Captopril	0-9	interleukin 1 beta	Homo sapiens	65-73
12228766-5	2002	Pro-IL-1beta concentrations followed the same pattern as that for mature IL-1beta when monocytes were preincubated with captopril.	Captopril	120-129	interleukin 1 beta	Homo sapiens	0-12
12228766-6	2002	Also, IL-1beta mRNA concentrations were reduced by captopril pretreatment in parallel with IL-1beta.	Captopril	51-60	interleukin 1 beta	Homo sapiens	6-14
12165085-11	2002	These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease.	t-hpmc	29-35	interleukin 1 beta	Homo sapiens	183-192
12165085-11	2002	These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease.	hydroxypropylmethylcellulose-lactose matrix	31-35	interleukin 1 beta	Homo sapiens	183-192
12165085-11	2002	These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease.	t-hpmc	116-122	interleukin 1 beta	Homo sapiens	183-192
12206592-5	2002	The upregulation of MMPs, induced by IL-1beta or TNFalpha, was reduced by the cyxlooxygenase-2 (COX-2) inhibitor NS-398, the p38 MAP-kinase inhibitor SB 203580, and the tyrosine kinase inhibitor herbimycin A.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	113-119	interleukin 1 beta	Homo sapiens	37-45
12206592-5	2002	The upregulation of MMPs, induced by IL-1beta or TNFalpha, was reduced by the cyxlooxygenase-2 (COX-2) inhibitor NS-398, the p38 MAP-kinase inhibitor SB 203580, and the tyrosine kinase inhibitor herbimycin A.	SB 203580	150-159	interleukin 1 beta	Homo sapiens	37-45
12206592-5	2002	The upregulation of MMPs, induced by IL-1beta or TNFalpha, was reduced by the cyxlooxygenase-2 (COX-2) inhibitor NS-398, the p38 MAP-kinase inhibitor SB 203580, and the tyrosine kinase inhibitor herbimycin A.	herbimycin	195-207	interleukin 1 beta	Homo sapiens	37-45
12206592-6	2002	In addition, MMP-1 and MMP-3 production, induced by IL-1beta, TNFalpha or EGF, was strongly reduced by the presence of the glucocorticoid dexamethasone.	Dexamethasone	138-151	interleukin 1 beta	Homo sapiens	52-60
12117969-4	2002	Vascular endothelial growth factor (VEGF), a direct inducer of angiogenesis, and interleukin-1beta (IL-1beta), a potentiator of VEGF, were detected within 12 and 6 h, respectively, in supernatants from phorbol 12-myristate 13-acetate-differentiated human THP-1 macrophages exposed to live B. henselae.	Tetradecanoylphorbol Acetate	202-233	interleukin 1 beta	Homo sapiens	81-98
12117969-4	2002	Vascular endothelial growth factor (VEGF), a direct inducer of angiogenesis, and interleukin-1beta (IL-1beta), a potentiator of VEGF, were detected within 12 and 6 h, respectively, in supernatants from phorbol 12-myristate 13-acetate-differentiated human THP-1 macrophages exposed to live B. henselae.	Tetradecanoylphorbol Acetate	202-233	interleukin 1 beta	Homo sapiens	100-108
12214898-4	2002	In this study, we examined the effect of two cytokines, IL-1beta and TNF-alpha, on the expression of guanine nucleotide binding regulatory proteins (G-proteins), Gs alpha and Gi alpha-3, by Western blotting in the CD4+ cells of nonatopic nonasthmatic (NANA), atopic nonasthmatic (ANA), and atopic asthmatic (AA) subjects.	Guanine Nucleotides	101-119	interleukin 1 beta	Homo sapiens	56-64
12228766-9	2002	Thus captopril reduced TNF-alpha-induced IL-1beta and IL-1betamRNA synthesis in monocytes, in vitro, probably through interference with NF-kappaB activation of the IL-1beta gene.	Captopril	5-14	interleukin 1 beta	Homo sapiens	41-49
12228766-9	2002	Thus captopril reduced TNF-alpha-induced IL-1beta and IL-1betamRNA synthesis in monocytes, in vitro, probably through interference with NF-kappaB activation of the IL-1beta gene.	Captopril	5-14	interleukin 1 beta	Homo sapiens	41-45
12228766-9	2002	Thus captopril reduced TNF-alpha-induced IL-1beta and IL-1betamRNA synthesis in monocytes, in vitro, probably through interference with NF-kappaB activation of the IL-1beta gene.	Captopril	5-14	interleukin 1 beta	Homo sapiens	54-62
12211491-4	2002	The aim of this study was to evaluate the effect of periodontal treatment in the form of scaling and root planing (SRP) and locally administered minocycline microspheres on the GCF levels of ICTP and IL-1.	Minocycline	145-156	interleukin 1 beta	Homo sapiens	200-204
12211491-14	2002	Furthermore, local administration of minocycline microspheres led to a potent short-term reduction in GCF IL-1 levels.	Minocycline	37-48	interleukin 1 beta	Homo sapiens	106-110
12211491-15	2002	Additional studies are needed to address whether repeated administration of scaling and root planing along with minocycline microspheres will achieve long-term reductions in GCF ICTP and IL-1 levels.	Minocycline	112-123	interleukin 1 beta	Homo sapiens	187-191
12361727-7	2002	After 6 days of preincubation, all three stimuli increased progesterone production, and this preincubation period was used in the remainder of the study.LH and IL-1beta increased the intracellular levels of 5,6-epoxyeicosatrienoic acid (5,6-EpETrE) maximally after 10 min, whereas db.	5,6-epoxy-8,11,14-eicosatrienoic acid	207-235	interleukin 1 beta	Homo sapiens	160-168
12361727-7	2002	After 6 days of preincubation, all three stimuli increased progesterone production, and this preincubation period was used in the remainder of the study.LH and IL-1beta increased the intracellular levels of 5,6-epoxyeicosatrienoic acid (5,6-EpETrE) maximally after 10 min, whereas db.	5,6-epoxy-8,11,14-eicosatrienoic acid	237-247	interleukin 1 beta	Homo sapiens	160-168
12141945-1	2002	Initial experiments in the present study investigated the effects of epidermal growth factor (EGF), interleukin 1beta (IL-1beta) and sodium nitroprusside (a nitric oxide donor) on the output of prostaglandins from guinea-pig uterus on day 7 of the oestrous cycle.	Prostaglandins	194-208	interleukin 1 beta	Homo sapiens	100-117
12130681-9	2002	Both (-)-Syn and (-)-Anti enantiomers of A276575 were potent inhibitors of IL-1beta-stimulated PGE2 production in A549 lung epithelial cells; unexpectedly, however, only the (-)-Anti enantiomer inhibited regulated on T-cell activation, normal T-cell expressed and secreted (RANTES) production in A549 cells.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	75-83
12154205-1	2002	OBJECTIVE: To compare the time- and concentration-dependent effects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) on the induction of nitric oxide synthase (NOS), the production of nitric oxide (NO) and the expression of aggrecan and hyaluronan (HA) in chondrocytes.	Nitric Oxide	165-177	interleukin 1 beta	Homo sapiens	116-133
12154205-1	2002	OBJECTIVE: To compare the time- and concentration-dependent effects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) on the induction of nitric oxide synthase (NOS), the production of nitric oxide (NO) and the expression of aggrecan and hyaluronan (HA) in chondrocytes.	Nitric Oxide	165-177	interleukin 1 beta	Homo sapiens	135-143
12141945-1	2002	Initial experiments in the present study investigated the effects of epidermal growth factor (EGF), interleukin 1beta (IL-1beta) and sodium nitroprusside (a nitric oxide donor) on the output of prostaglandins from guinea-pig uterus on day 7 of the oestrous cycle.	Prostaglandins	194-208	interleukin 1 beta	Homo sapiens	119-127
12195700-4	2002	Similarly, release of interleukin (IL)-1 alpha, IL-1 beta and tumor necrosis factor (TNF)-alpha from plasmin-stimulated PM was concentration-dependently inhibited by ciglitazone, but not by clofibric acid, while the LPS-induced TNF-alpha release remained unaffected by any of both PPAR agonists.	ciglitazone	166-177	interleukin 1 beta	Homo sapiens	48-57
11976320-6	2002	However, IL-1beta-induced NF-kappaB activity is attenuated by increased intracellular calcium in response to ionomycin, UTP, or thapsigargin or by overexpression of CaMKKc and/or Akt.	Calcium	86-93	interleukin 1 beta	Homo sapiens	9-17
12411029-2	2002	METHODS: In the present study, the effect of IL-1beta and IL-1ra on aromatase (Arom) activity and mRNA expression in human osteoblast-like cells was investigated by [(3)H] water released upon the conversion of [1beta-(3)H] androstenedione to estrone and the reverse-transcription polymerase cain reaction (RT-PCR) method.	Water	172-177	interleukin 1 beta	Homo sapiens	45-53
12140176-5	2002	Using specific neutralizing antibodies, LC migration induced following skin sensitization with oxazolone (Ox) was found to be dependent upon IL-1beta and independent of a requirement for IL-1alpha.	Oxazolone	95-104	interleukin 1 beta	Homo sapiens	141-149
12411029-2	2002	METHODS: In the present study, the effect of IL-1beta and IL-1ra on aromatase (Arom) activity and mRNA expression in human osteoblast-like cells was investigated by [(3)H] water released upon the conversion of [1beta-(3)H] androstenedione to estrone and the reverse-transcription polymerase cain reaction (RT-PCR) method.	h] androstenedione	220-238	interleukin 1 beta	Homo sapiens	45-53
12411029-2	2002	METHODS: In the present study, the effect of IL-1beta and IL-1ra on aromatase (Arom) activity and mRNA expression in human osteoblast-like cells was investigated by [(3)H] water released upon the conversion of [1beta-(3)H] androstenedione to estrone and the reverse-transcription polymerase cain reaction (RT-PCR) method.	Estrone	242-249	interleukin 1 beta	Homo sapiens	45-53
12126971-4	2002	Acetylsalicylic acid, indomethacin, nimesulide and rofecoxib were all effective in eliminating the increase in endothelin ET(B) receptor-mediated contraction induced by interleukin-1 beta, but only indomethacin and rofecoxib significantly reduced the spontaneous development of this reaction in cultured arteries.	Aspirin	0-20	interleukin 1 beta	Homo sapiens	169-187
12126971-4	2002	Acetylsalicylic acid, indomethacin, nimesulide and rofecoxib were all effective in eliminating the increase in endothelin ET(B) receptor-mediated contraction induced by interleukin-1 beta, but only indomethacin and rofecoxib significantly reduced the spontaneous development of this reaction in cultured arteries.	Indomethacin	22-34	interleukin 1 beta	Homo sapiens	169-187
12126971-4	2002	Acetylsalicylic acid, indomethacin, nimesulide and rofecoxib were all effective in eliminating the increase in endothelin ET(B) receptor-mediated contraction induced by interleukin-1 beta, but only indomethacin and rofecoxib significantly reduced the spontaneous development of this reaction in cultured arteries.	nimesulide	36-46	interleukin 1 beta	Homo sapiens	169-187
12126971-4	2002	Acetylsalicylic acid, indomethacin, nimesulide and rofecoxib were all effective in eliminating the increase in endothelin ET(B) receptor-mediated contraction induced by interleukin-1 beta, but only indomethacin and rofecoxib significantly reduced the spontaneous development of this reaction in cultured arteries.	rofecoxib	51-60	interleukin 1 beta	Homo sapiens	169-187
12151017-5	2002	Recent studies on immune cells demonstrate that extracellular ATP can act as a potent stimulus for the maturation and release of interleukin-1beta, via activation of P2X7 receptors.	Adenosine Triphosphate	62-65	interleukin 1 beta	Homo sapiens	129-146
11976320-6	2002	However, IL-1beta-induced NF-kappaB activity is attenuated by increased intracellular calcium in response to ionomycin, UTP, or thapsigargin or by overexpression of CaMKKc and/or Akt.	Ionomycin	109-118	interleukin 1 beta	Homo sapiens	9-17
11976320-6	2002	However, IL-1beta-induced NF-kappaB activity is attenuated by increased intracellular calcium in response to ionomycin, UTP, or thapsigargin or by overexpression of CaMKKc and/or Akt.	Uridine Triphosphate	120-123	interleukin 1 beta	Homo sapiens	9-17
11976320-6	2002	However, IL-1beta-induced NF-kappaB activity is attenuated by increased intracellular calcium in response to ionomycin, UTP, or thapsigargin or by overexpression of CaMKKc and/or Akt.	Thapsigargin	128-140	interleukin 1 beta	Homo sapiens	9-17
11976320-9	2002	Furthermore, a dominant negative mutant of Akt abolishes IKKbeta inhibition by CaMKKc and ionomycin, suggesting that Akt acts as a mediator of CaMKK signaling to inhibit IL-1beta-induced IKK activity at an upstream target site.	Ionomycin	90-99	interleukin 1 beta	Homo sapiens	170-178
12124863-6	2002	RESULTS: IL-1 beta induced robust expression of COX-2 and PGE(2) in OA meniscus, synovial membrane, and osteophytic fibrocartilage explants, whereas low levels were produced in OA articular cartilage.	Prostaglandins E	58-61	interleukin 1 beta	Homo sapiens	9-18
12126020-0	2002	Exposure to 200 ppm of methanol increases the concentrations of interleukin-1beta and interleukin-8 in nasal secretions of healthy volunteers.	Methanol	23-31	interleukin 1 beta	Homo sapiens	64-81
12126020-7	2002	The median concentrations of IL-8 and IL-1beta were significantly elevated after exposure to 200 ppm of methanol as compared to exposure to 20 ppm (IL-1beta, 21.4 versus 8.3 pg/mL, p = .001; IL-8, 424 versus 356 pg/mL, p = .02).	Methanol	104-112	interleukin 1 beta	Homo sapiens	38-46
12126020-9	2002	Both IL-8 and IL-1beta proved to be sensitive indicators for subclinical irritating effects of methanol in vivo.	Methanol	95-103	interleukin 1 beta	Homo sapiens	14-22
12124863-9	2002	Dexamethasone, neutralizing IL-1 beta antibody, or the selective COX-2 inhibitor, SC-236, attenuated both the IL-1 beta-induced PGE(2) production and cartilage proteoglycan degradation in these cocultures.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	110-119
12124863-9	2002	Dexamethasone, neutralizing IL-1 beta antibody, or the selective COX-2 inhibitor, SC-236, attenuated both the IL-1 beta-induced PGE(2) production and cartilage proteoglycan degradation in these cocultures.	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	82-88	interleukin 1 beta	Homo sapiens	110-119
12124863-9	2002	Dexamethasone, neutralizing IL-1 beta antibody, or the selective COX-2 inhibitor, SC-236, attenuated both the IL-1 beta-induced PGE(2) production and cartilage proteoglycan degradation in these cocultures.	Prostaglandins E	128-131	interleukin 1 beta	Homo sapiens	110-119
12124863-11	2002	CONCLUSION: IL-1 beta-induced production of COX-2 protein and PGE(2) was low in OA articular cartilage compared with that in the other OA tissues examined.	Prostaglandins E	62-65	interleukin 1 beta	Homo sapiens	12-21
12124863-12	2002	IL-1 beta-mediated degradation of cartilage proteoglycans in OA synovial membrane-cartilage cocultures was blocked by the selective COX-2 inhibitor, SC-236, and the effect of SC-236 was reversed by the addition of exogenous PGE(2).	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	149-155	interleukin 1 beta	Homo sapiens	0-9
12124863-12	2002	IL-1 beta-mediated degradation of cartilage proteoglycans in OA synovial membrane-cartilage cocultures was blocked by the selective COX-2 inhibitor, SC-236, and the effect of SC-236 was reversed by the addition of exogenous PGE(2).	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	175-181	interleukin 1 beta	Homo sapiens	0-9
12124863-12	2002	IL-1 beta-mediated degradation of cartilage proteoglycans in OA synovial membrane-cartilage cocultures was blocked by the selective COX-2 inhibitor, SC-236, and the effect of SC-236 was reversed by the addition of exogenous PGE(2).	Prostaglandins E	224-227	interleukin 1 beta	Homo sapiens	0-9
12124863-13	2002	Our data suggest that induction of synovial COX-2-produced PGE(2) is one mechanism by which IL-1 beta modulates cartilage proteoglycan degradation in OA.	Prostaglandins E	59-62	interleukin 1 beta	Homo sapiens	92-101
12085250-12	2002	More specifically, docetaxel demonstrated a more pronounced effect on enhancing MLR, NK, LAK activity and IFN-gamma, IL-2, IL-6, and GM-CSF levels, as well as caused more potent reduction in IL-1 and TNF-alpha levels when compared to paclitaxel.	Docetaxel	19-28	interleukin 1 beta	Homo sapiens	191-195
12085250-13	2002	The present study indicates that patients responded to treatment of advanced breast cancer with single-agent paclitaxel or docetaxel leads to an increase in serum IFN-gamma, IL-2, IL-6, GM-CSF cytokine levels and enhancement of PBMC NK and LAK cell activity, while they both lead to a decrease of acute phase serum cytokine levels of IL-1 and TNF-alpha.	Paclitaxel	109-119	interleukin 1 beta	Homo sapiens	334-338
12085250-13	2002	The present study indicates that patients responded to treatment of advanced breast cancer with single-agent paclitaxel or docetaxel leads to an increase in serum IFN-gamma, IL-2, IL-6, GM-CSF cytokine levels and enhancement of PBMC NK and LAK cell activity, while they both lead to a decrease of acute phase serum cytokine levels of IL-1 and TNF-alpha.	Docetaxel	123-132	interleukin 1 beta	Homo sapiens	334-338
12065499-3	2002	In addition, the level of expression of mRNAs for tumor necrosis factor alpha and interleukin-1 beta, -6, and -8 was also upregulated by the lipopeptides and/or extracellular ATP, but that of interleukin-10 was not.	Adenosine Triphosphate	175-178	interleukin 1 beta	Homo sapiens	82-112
12115600-3	2002	Indeed, addition of hyperosmotic, pathophysiologically relevant concentrations of NaCl effectively inhibited IL-1beta or TNF-alpha induction of VCAM-1, but not E-selectin, at the level of mRNA and cell surface protein.	Sodium Chloride	82-86	interleukin 1 beta	Homo sapiens	109-117
12060565-4	2002	1) Bleomycin-treated THP-1 cells increased tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, and IL-1beta production in dose- and time-dependent patterns, as we have observed with SP-A.	Bleomycin	3-12	interleukin 1 beta	Homo sapiens	102-110
12115742-6	2002	In response to IL-1beta (0.1 ng/ml), NO and PGE(2) release was maximal on Day 2 or 3 and then declined to near basal level by Day 14.	Dinoprostone	44-50	interleukin 1 beta	Homo sapiens	15-23
12115737-5	2002	When Caco-2 cells were treated with IL-1beta in the presence of the MAPK inhibitor, PD-98059, IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	84-92	interleukin 1 beta	Homo sapiens	36-44
12107235-1	2002	We investigated the regulation of PG production in human endometrial stromal cells (ESC) by IL-1beta.	pg	34-36	interleukin 1 beta	Homo sapiens	92-100
12115742-10	2002	IL-1beta increased glucose consumption and lactate production throughout the treatment.	Glucose	19-26	interleukin 1 beta	Homo sapiens	0-8
12107235-2	2002	We found that cyclooxygenase-2 (COX-2) mRNA and protein levels and PGE(2) production in ESC were significantly increased by IL-1beta.	Dinoprostone	67-73	interleukin 1 beta	Homo sapiens	124-132
12115737-5	2002	When Caco-2 cells were treated with IL-1beta in the presence of the MAPK inhibitor, PD-98059, IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	166-174	interleukin 1 beta	Homo sapiens	36-44
12115742-10	2002	IL-1beta increased glucose consumption and lactate production throughout the treatment.	Lactic Acid	43-50	interleukin 1 beta	Homo sapiens	0-8
12107235-3	2002	COX-2 mRNA, protein, and PGE(2) levels in IL-1beta-treated ESC were decreased by a PKA inhibitor, a nuclear factor (NF-kappaB) inhibitor, and an ERK1/2 inhibitor, but not by a p38 MAPK inhibitor or a PKC inhibitor, suggesting the possible involvement of PKA, NF-kappaB, and/or the ERK1/2 signaling pathway(s) in IL-1beta-mediated COX-2 gene induction in ESC.	Prostaglandins E	25-28	interleukin 1 beta	Homo sapiens	42-50
12115742-13	2002	Like the OA, IL-1beta-induced NO and PGE(2) release decreased over time.	Dinoprostone	37-43	interleukin 1 beta	Homo sapiens	13-21
12115742-14	2002	In conclusion, with prolonged exposure to IL-1beta, human chondrocytes develop selective tolerance involving NO and PGE(2) release but not MMP-13 production, metabolic activity, or matrix metabolism.	Dinoprostone	116-122	interleukin 1 beta	Homo sapiens	42-50
12099714-5	2002	Such an induction of EPAS1 by IL-1beta was efficiently inhibited by the pretreatment of the cells with Src kinase inhibitors, such as herbimycin A and PP1.	herbimycin	134-146	interleukin 1 beta	Homo sapiens	30-38
12097485-11	2002	Treatment of the cocultures with IL-1beta or tumor necrosis factor-alpha (TNF-alpha) results in production of PGE(2) and OSM.	Prostaglandins E	110-113	interleukin 1 beta	Homo sapiens	33-41
12097485-12	2002	PGE(2) produced in the cocultures is responsible for OSM induction, because pretreatment with indomethacin, an inhibitor of prostaglandin synthesis, as well as depletion of PGE(2), abrogate OSM expression induced by IL-1beta or TNF-alpha.	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	216-224
12097485-12	2002	PGE(2) produced in the cocultures is responsible for OSM induction, because pretreatment with indomethacin, an inhibitor of prostaglandin synthesis, as well as depletion of PGE(2), abrogate OSM expression induced by IL-1beta or TNF-alpha.	Indomethacin	94-106	interleukin 1 beta	Homo sapiens	216-224
12101284-2	2002	However, because extracellular ATP has been shown to affect monocytes with respect to IL-1beta release, we hypothesized that the P2X(7) receptor is also present and functional in a subpopulation of blood monocytes.	Adenosine Triphosphate	31-34	interleukin 1 beta	Homo sapiens	86-94
12113880-8	2002	CONCLUSION: Interferon gamma acts as a partial antagonist of IL-1 signaling in this cell model at a site upstream from the activation of the NF-kappaB pathway, causing a partial inhibition of COX-2 expression and PGE(2) production.	Prostaglandins E	213-216	interleukin 1 beta	Homo sapiens	61-65
12113880-0	2002	Interferon gamma antagonizes interleukin-1beta-induced cyclooxygenase-2 expression and prostaglandin E(2) production in human myometrial cells.	Dinoprostone	87-105	interleukin 1 beta	Homo sapiens	29-46
12127835-16	2002	CONCLUSIONS: The stimulation of IL-1beta, NO and PGE(2) production by LPS is differentially controlled by reactive oxygen species (ROS).	Reactive Oxygen Species	106-129	interleukin 1 beta	Homo sapiens	32-40
12127835-0	2002	Regulation by reactive oxygen species of interleukin-1beta, nitric oxide and prostaglandin E(2) production by human chondrocytes.	Reactive Oxygen Species	14-37	interleukin 1 beta	Homo sapiens	41-58
12136890-8	2002	IL-15 production stimulated by interferon-gamma (IFN-gamma), IL-1beta, or lipopolysaccharide were also strongly inhibited by PGE2.	Dinoprostone	125-129	interleukin 1 beta	Homo sapiens	61-69
12137744-3	2002	IL-1beta secretion after vaginal delivery (VD) was (mean +/- SEM fmol/mg wet weight/3h) 0.193 +/- 0.005 (basal) and 0.549 +/- 0.18 (+1n M TNFalpha) and was more sensitive to TNFalpha dose after elective Caesarean section in the absence of clinical labour (CS) than VD.	Tritium	84-86	interleukin 1 beta	Homo sapiens	0-8
12137744-5	2002	The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha-stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50.	SB 203580	15-23	interleukin 1 beta	Homo sapiens	147-155
12137744-5	2002	The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha-stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	25-32	interleukin 1 beta	Homo sapiens	147-155
12137744-5	2002	The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha-stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50.	SN50	34-38	interleukin 1 beta	Homo sapiens	147-155
12137744-5	2002	The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha-stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50.	Cycloheximide	40-53	interleukin 1 beta	Homo sapiens	147-155
12137744-5	2002	The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha-stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50.	D-ribofuranosylbenzimidazole	58-86	interleukin 1 beta	Homo sapiens	147-155
12127835-1	2002	OBJECTIVES: To determine the effects of two drugs, N-monomethyl-L-arginine (L-NMMA) and N-acetylcysteine (NAC), on interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production by human chondrocytes.	omega-N-Methylarginine	76-82	interleukin 1 beta	Homo sapiens	115-132
12127835-16	2002	CONCLUSIONS: The stimulation of IL-1beta, NO and PGE(2) production by LPS is differentially controlled by reactive oxygen species (ROS).	Reactive Oxygen Species	131-134	interleukin 1 beta	Homo sapiens	32-40
12061876-1	2002	On the basis of model imidazole inhibitors of cytokine release, a series of novel pyridinyl pyrimidine derivatives was prepared and tested on their ability to inhibit the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) from peripheral blood mononuclear cells (PBMC) and human whole blood.	pyridinyl pyrimidine	82-102	interleukin 1 beta	Homo sapiens	226-243
12061876-1	2002	On the basis of model imidazole inhibitors of cytokine release, a series of novel pyridinyl pyrimidine derivatives was prepared and tested on their ability to inhibit the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) from peripheral blood mononuclear cells (PBMC) and human whole blood.	pyridinyl pyrimidine	82-102	interleukin 1 beta	Homo sapiens	245-253
12061876-3	2002	Modification of the substituent at the 2 position of the pyrimidine led to the most active compound 14 which inhibited release of TNF-alpha (IC(50) = 3.2 microM) and IL-1beta (IC(50) = 2.3 microM) from PBMC as effectively as the model imidazole inhibitor ML 3163 (TNF-alpha, IC(50) = 3.7 microM; IL-1beta, IC(50) = 0.9 microM).	pyrimidine	57-67	interleukin 1 beta	Homo sapiens	166-174
12061876-3	2002	Modification of the substituent at the 2 position of the pyrimidine led to the most active compound 14 which inhibited release of TNF-alpha (IC(50) = 3.2 microM) and IL-1beta (IC(50) = 2.3 microM) from PBMC as effectively as the model imidazole inhibitor ML 3163 (TNF-alpha, IC(50) = 3.7 microM; IL-1beta, IC(50) = 0.9 microM).	pyrimidine	57-67	interleukin 1 beta	Homo sapiens	296-304
12084593-11	2002	In vitro, atorvastatin decreased both the basal and the interleukin-1beta-induced VEGF release in HCASMC.	Atorvastatin	10-22	interleukin 1 beta	Homo sapiens	56-73
12051728-4	2002	With regard to IFN-alpha signaling, IL-1beta enhanced both tyrosine and serine phosphorylation of STAT1 through p38 mitogen-activated protein kinase activation.	Tyrosine	59-67	interleukin 1 beta	Homo sapiens	36-44
12051728-4	2002	With regard to IFN-alpha signaling, IL-1beta enhanced both tyrosine and serine phosphorylation of STAT1 through p38 mitogen-activated protein kinase activation.	Serine	72-78	interleukin 1 beta	Homo sapiens	36-44
11997668-1	2002	AIMS/HYPOTHESIS: It is well established that long-term exposure of isolated beta cells to cytokines [e.g., IL-1beta] results in increased expression of inducible nitric oxide synthase and subsequent release of nitric oxide, which in turn, has been shown to mediate a wide array of effects, including alterations in cellular high-energy metabolism.	Nitric Oxide	162-174	interleukin 1 beta	Homo sapiens	107-115
11997668-2	2002	In this context, several extant studies have demonstrated significant reduction in adenine and guanine nucleotide triphosphate levels in beta cells exposed to IL-1beta.	Adenine	83-90	interleukin 1 beta	Homo sapiens	159-167
11997668-2	2002	In this context, several extant studies have demonstrated significant reduction in adenine and guanine nucleotide triphosphate levels in beta cells exposed to IL-1beta.	guanine nucleotide triphosphate	95-126	interleukin 1 beta	Homo sapiens	159-167
11996950-5	2002	Incubation of cell cultures with interleukin-1beta (IL-1beta) for 24 h caused a significant increase in nitrite accumulation.	Nitrites	104-111	interleukin 1 beta	Homo sapiens	33-50
11996950-5	2002	Incubation of cell cultures with interleukin-1beta (IL-1beta) for 24 h caused a significant increase in nitrite accumulation.	Nitrites	104-111	interleukin 1 beta	Homo sapiens	52-60
11996950-9	2002	Use of specific tyrosine kinase inhibitor herbimycin A, genistein, or PP2 (Src family kinase inhibitor) indicated that tyrosine kinases are required for IL-1beta-stimulated and beta-VLDL-enhanced nitrite accumulation, while specific inhibition of ERK1/2 or p38-MAP kinase had no effects.	Genistein	56-65	interleukin 1 beta	Homo sapiens	153-161
11996950-6	2002	Although beta-VLDL alone did not increase nitrite accumulation in unstimulated VSMC, beta-VLDL significantly enhanced nitrite accumulation in IL-1beta-stimulated VSMC in a time- and dose-dependent manner.	Nitrites	118-125	interleukin 1 beta	Homo sapiens	142-150
11996950-9	2002	Use of specific tyrosine kinase inhibitor herbimycin A, genistein, or PP2 (Src family kinase inhibitor) indicated that tyrosine kinases are required for IL-1beta-stimulated and beta-VLDL-enhanced nitrite accumulation, while specific inhibition of ERK1/2 or p38-MAP kinase had no effects.	Nitrites	196-203	interleukin 1 beta	Homo sapiens	153-161
11996950-7	2002	beta-VLDL-induced nitrite accumulation in IL-1beta-stimulated VSMC was accompanied by an increase in iNOS protein and mRNA expression.	Nitrites	18-25	interleukin 1 beta	Homo sapiens	42-50
11996950-10	2002	Our results suggest that beta-VLDL enhances iNOS expression and nitrite accumulation in IL-1beta-stimulated VSMC through tyrosine kinase(s)-dependent mechanisms.	Nitrites	64-71	interleukin 1 beta	Homo sapiens	88-96
11996950-9	2002	Use of specific tyrosine kinase inhibitor herbimycin A, genistein, or PP2 (Src family kinase inhibitor) indicated that tyrosine kinases are required for IL-1beta-stimulated and beta-VLDL-enhanced nitrite accumulation, while specific inhibition of ERK1/2 or p38-MAP kinase had no effects.	herbimycin	42-54	interleukin 1 beta	Homo sapiens	153-161
12021045-1	2002	Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis.	Prostaglandins	91-93	interleukin 1 beta	Homo sapiens	19-27
12021045-1	2002	Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis.	Prostaglandins	189-191	interleukin 1 beta	Homo sapiens	0-17
12021045-1	2002	Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis.	Prostaglandins	76-89	interleukin 1 beta	Homo sapiens	0-17
12021045-1	2002	Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis.	Prostaglandins	76-89	interleukin 1 beta	Homo sapiens	19-27
12021045-1	2002	Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis.	Prostaglandins	91-93	interleukin 1 beta	Homo sapiens	0-17
12021045-1	2002	Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis.	Prostaglandins	189-191	interleukin 1 beta	Homo sapiens	19-27
11997239-4	2002	IL-1beta produced a dose-dependent increase in MMP activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min.	18alpha-glycyrrhetinic acid	120-147	interleukin 1 beta	Homo sapiens	0-8
11997239-4	2002	IL-1beta produced a dose-dependent increase in MMP activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min.	Octanols	152-159	interleukin 1 beta	Homo sapiens	0-8
12003710-6	2002	We have also shown that central SNS activity is modulated by local expression of nitric oxide, which, in turn, is regulated by interleukin-1b.	Nitric Oxide	81-93	interleukin 1 beta	Homo sapiens	127-141
12031711-1	2002	OBJECTIVE: We investigated the effects of the statins, cerivastatin and fluvastatin, on the induction of nitric oxide (NO) production in vascular smooth muscle cells (VSMC) stimulated by interleukin-1beta (IL-1) or in combination with interferon-gamma (IFN).	cerivastatin	55-67	interleukin 1 beta	Homo sapiens	187-204
12031711-1	2002	OBJECTIVE: We investigated the effects of the statins, cerivastatin and fluvastatin, on the induction of nitric oxide (NO) production in vascular smooth muscle cells (VSMC) stimulated by interleukin-1beta (IL-1) or in combination with interferon-gamma (IFN).	Fluvastatin	72-83	interleukin 1 beta	Homo sapiens	187-204
12031711-1	2002	OBJECTIVE: We investigated the effects of the statins, cerivastatin and fluvastatin, on the induction of nitric oxide (NO) production in vascular smooth muscle cells (VSMC) stimulated by interleukin-1beta (IL-1) or in combination with interferon-gamma (IFN).	Nitric Oxide	105-117	interleukin 1 beta	Homo sapiens	187-204
12031711-11	2002	The synthesis of BH4 and GTPCH mRNA induced by IL-1/IFN were enhanced by both statins.	sapropterin	17-20	interleukin 1 beta	Homo sapiens	47-55
12031711-13	2002	Furthermore, the geranylgeranyltransferase I inhibitor GGTI-298 significantly increased IL-1/IFN-induced NO production.	GGTI 298	55-63	interleukin 1 beta	Homo sapiens	88-96
12031964-6	2002	Electromobility shift assays demonstrated that sodium salicylate inhibits IL-1beta-induced nuclear factor-kappaB (NF-kappaB) activation.	Sodium Salicylate	47-64	interleukin 1 beta	Homo sapiens	74-82
12031964-0	2002	Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function.	Sodium Salicylate	73-90	interleukin 1 beta	Homo sapiens	14-31
12031964-7	2002	Sodium salicylate also prevented IL-1beta from inducing EP3 and cyclooxygenase (COX)-2 gene expression in islets and thereby prevented IL-1beta from inhibiting glucose-induced insulin secretion.	Sodium Salicylate	0-17	interleukin 1 beta	Homo sapiens	33-41
12031964-7	2002	Sodium salicylate also prevented IL-1beta from inducing EP3 and cyclooxygenase (COX)-2 gene expression in islets and thereby prevented IL-1beta from inhibiting glucose-induced insulin secretion.	Sodium Salicylate	0-17	interleukin 1 beta	Homo sapiens	135-143
12031964-7	2002	Sodium salicylate also prevented IL-1beta from inducing EP3 and cyclooxygenase (COX)-2 gene expression in islets and thereby prevented IL-1beta from inhibiting glucose-induced insulin secretion.	Glucose	160-167	interleukin 1 beta	Homo sapiens	33-41
12031964-7	2002	Sodium salicylate also prevented IL-1beta from inducing EP3 and cyclooxygenase (COX)-2 gene expression in islets and thereby prevented IL-1beta from inhibiting glucose-induced insulin secretion.	Glucose	160-167	interleukin 1 beta	Homo sapiens	135-143
12031964-8	2002	These findings indicate that the sites of action through which sodium salicylate inhibits these negative effects of IL-1beta on beta-cell function include activation of NF-kappaB as well as generation of PGE(2) by COX-2.	Sodium Salicylate	63-80	interleukin 1 beta	Homo sapiens	116-124
12201223-10	2002	These results led us to the hypothesis that inflammatory cytokines such as IL-6 and IL-1 beta regulate proliferation of breast cancer cells through estrogen production by steroid-catalyzing enzymes in the tissue.	Steroids	171-178	interleukin 1 beta	Homo sapiens	84-93
12115655-4	2002	Since the release of IL-1beta in LPS-stimulated whole blood was blocked by the caspase-1 inhibitor YVAD-cmk, processing of proIL-1beta appears to depend on caspase-1 activity.	YVAD	99-103	interleukin 1 beta	Homo sapiens	21-29
12115655-4	2002	Since the release of IL-1beta in LPS-stimulated whole blood was blocked by the caspase-1 inhibitor YVAD-cmk, processing of proIL-1beta appears to depend on caspase-1 activity.	YVAD	99-103	interleukin 1 beta	Homo sapiens	123-134
12132790-13	2002	This is against the hypothesis that nicotine exerts a direct pro-inflammatory action via interleukin-1beta and interleukin-8.	Nicotine	36-44	interleukin 1 beta	Homo sapiens	89-106
11996939-10	2002	This initial demonstration of IL-1beta regulation of STS implies that IL-1beta may control the steroid microenvironment in human uterine endometrium by reducing biologic action of estrogen.	Steroids	95-102	interleukin 1 beta	Homo sapiens	30-38
12050211-9	2002	A combination of (Bt)(2)cAMP, 3-isobutyl-1-myethylxanthine, and PGE(2), known as inducers of promoter II-driven transcription, also increased aromatase activity, but the increases found were smaller than that induced by dexamethasone and IL-1beta.	3-isobutyl-1-myethylxanthine	30-58	interleukin 1 beta	Homo sapiens	238-246
12050211-9	2002	A combination of (Bt)(2)cAMP, 3-isobutyl-1-myethylxanthine, and PGE(2), known as inducers of promoter II-driven transcription, also increased aromatase activity, but the increases found were smaller than that induced by dexamethasone and IL-1beta.	Prostaglandins E	64-67	interleukin 1 beta	Homo sapiens	238-246
12069185-8	2002	Iron supplementation of macrophage cultures significantly increased interleukin-1beta-induced TNF release.	Iron	0-4	interleukin 1 beta	Homo sapiens	68-85
12072296-0	2002	Differential modulation of synthesis of human IL-1 beta and IL-1 receptor antagonist by cyclosporin A.	Cyclosporine	88-101	interleukin 1 beta	Homo sapiens	46-55
11996939-10	2002	This initial demonstration of IL-1beta regulation of STS implies that IL-1beta may control the steroid microenvironment in human uterine endometrium by reducing biologic action of estrogen.	Steroids	95-102	interleukin 1 beta	Homo sapiens	70-78
12065072-5	2002	Moreover, angiotensin II-stimulated PKB activation is inhibited by long-term pretreatment with interleukin-1 beta, an effect that is reversed by the NO synthase inhibitor, N(G)-monomethyl-L-arginine (L-NMMA).	omega-N-Methylarginine	172-198	interleukin 1 beta	Homo sapiens	95-113
12034804-4	2002	However, an impact of IL-1B(-511) on Abeta(40) load (p < 0.05) was detected.	UNII-042A8N37WH	37-42	interleukin 1 beta	Homo sapiens	22-27
11994438-5	2002	Remarkably, these Vgamma2Vdelta2 T cells, functioning similarly to MIF in part, counteracted inhibition of dexamethasone on production of IL-1beta and TNF-alpha.	Dexamethasone	107-120	interleukin 1 beta	Homo sapiens	138-146
11847219-0	2002	Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression.	Dinoprostone	17-33	interleukin 1 beta	Homo sapiens	47-64
11847219-11	2002	These results indicate that the induction of PGHS-2 and mPGES by IL-1beta underlies robust PGE(2) production in orbital fibroblasts.	Dinoprostone	91-97	interleukin 1 beta	Homo sapiens	65-73
12065072-5	2002	Moreover, angiotensin II-stimulated PKB activation is inhibited by long-term pretreatment with interleukin-1 beta, an effect that is reversed by the NO synthase inhibitor, N(G)-monomethyl-L-arginine (L-NMMA).	omega-N-Methylarginine	200-206	interleukin 1 beta	Homo sapiens	95-113
11997019-2	2002	The promoter has two parts, the [-247/+20] fragment of the human type IIA secreted phospholipase A2 gene promoter, which is stimulated by the pro-inflammatory cytokine interleukin-1beta (IL-1beta), and a double peroxisome proliferator-activated receptor response element that is activated by some eicosanoids and by non-steroidal anti-inflammatory drugs (NSAIDs).	Eicosanoids	297-308	interleukin 1 beta	Homo sapiens	168-185
11997019-2	2002	The promoter has two parts, the [-247/+20] fragment of the human type IIA secreted phospholipase A2 gene promoter, which is stimulated by the pro-inflammatory cytokine interleukin-1beta (IL-1beta), and a double peroxisome proliferator-activated receptor response element that is activated by some eicosanoids and by non-steroidal anti-inflammatory drugs (NSAIDs).	Eicosanoids	297-308	interleukin 1 beta	Homo sapiens	187-195
12063092-2	2002	In pulmonary A549 cells, TNF-alpha or interleukin-1 beta dramatically increased bradykinin B(1) and B(2) receptor mRNA expression and this response was prevented by dexamethasone.	Dexamethasone	165-178	interleukin 1 beta	Homo sapiens	38-56
12126649-0	2002	Osteoprotegerin levels increased by interleukin-1beta in human periodontal ligament cells are suppressed through prostaglandin E(2) synthesized de novo.	Prostaglandins E	113-128	interleukin 1 beta	Homo sapiens	36-53
12126649-3	2002	IL-1beta also increases prostaglandin E(2) (PGE(2)) production and stimulates bone resorption.	Dinoprostone	24-42	interleukin 1 beta	Homo sapiens	0-8
12126649-3	2002	IL-1beta also increases prostaglandin E(2) (PGE(2)) production and stimulates bone resorption.	Dinoprostone	44-50	interleukin 1 beta	Homo sapiens	0-8
12126649-4	2002	In the present study, we examined the involvement of PGE(2) in IL-1beta-induced increases in OPG levels in human periodontal ligament cells (HPL cells) in an effort to clarify apparently conflicting IL-1beta actions on bone resorption and understand IL-1beta-induced increases in secretion of OPG and PGE(2) in HPL cells.	Prostaglandins E	53-56	interleukin 1 beta	Homo sapiens	63-71
12126649-4	2002	In the present study, we examined the involvement of PGE(2) in IL-1beta-induced increases in OPG levels in human periodontal ligament cells (HPL cells) in an effort to clarify apparently conflicting IL-1beta actions on bone resorption and understand IL-1beta-induced increases in secretion of OPG and PGE(2) in HPL cells.	Prostaglandins E	301-304	interleukin 1 beta	Homo sapiens	63-71
12126649-5	2002	5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole, a mRNA synthesis inhibitor, partly inhibited the increase in OPG mRNA levels induced by IL-1beta.	Dichlororibofuranosylbenzimidazole	0-49	interleukin 1 beta	Homo sapiens	139-147
12126649-6	2002	Cycloheximide, a protein synthesis inhibitor, enhanced the stimulatory effect of IL-1beta.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	81-89
12126649-8	2002	Furthermore, etodolac reinforced the promotion of OPG expression by IL-1beta at the mRNA and protein levels.	Etodolac	13-21	interleukin 1 beta	Homo sapiens	68-76
12126649-10	2002	These findings suggest that the increase in OPG levels induced by IL-1beta in HPL cells is suppressed through PGE(2) synthesized de novo.	Prostaglandins E	110-113	interleukin 1 beta	Homo sapiens	66-74
12076961-2	2002	Nitric oxide inhibits apoptosis and inflammation by S-nitrosylation of the active site cysteine of caspases, the central effector molecules of cell death as well as maturation of IL-1beta and IL-18.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	179-187
12090138-11	2002	CONCLUSION: Our results prove that the model of differentiated THP-1 cells treated with PE particles is a suitable system to analyse differential gene expression patterns, since the induction of the major positive control genes TNF alpha and IL1 beta were detected by this approach.	pe	88-90	interleukin 1 beta	Homo sapiens	242-250
11971025-5	2002	We found that PPAR alpha ligands (clofibrate and WY14643) enhanced IL-1 beta-induced COX-2 expression in human astrocytes and microglia, while inhibiting IL-1 beta plus IFN-gamma induction of iNOS in astrocytes.	Clofibrate	34-44	interleukin 1 beta	Homo sapiens	67-76
11971025-5	2002	We found that PPAR alpha ligands (clofibrate and WY14643) enhanced IL-1 beta-induced COX-2 expression in human astrocytes and microglia, while inhibiting IL-1 beta plus IFN-gamma induction of iNOS in astrocytes.	Clofibrate	34-44	interleukin 1 beta	Homo sapiens	154-163
11971025-5	2002	We found that PPAR alpha ligands (clofibrate and WY14643) enhanced IL-1 beta-induced COX-2 expression in human astrocytes and microglia, while inhibiting IL-1 beta plus IFN-gamma induction of iNOS in astrocytes.	pirinixic acid	49-56	interleukin 1 beta	Homo sapiens	67-76
11971025-5	2002	We found that PPAR alpha ligands (clofibrate and WY14643) enhanced IL-1 beta-induced COX-2 expression in human astrocytes and microglia, while inhibiting IL-1 beta plus IFN-gamma induction of iNOS in astrocytes.	pirinixic acid	49-56	interleukin 1 beta	Homo sapiens	154-163
12126643-8	2002	SB203580, a specific P38 MAPK inhibitor, partially blocked IL-1beta induction of IL-8 mRNA, IL-8 promoter activity, and AP-1 nuclear extract binding but not NF-kappaB DNA binding.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	59-67
12010778-4	2002	NS-398 (1 microM), a cyclo-oxygenase-2 (COX-2) inhibitor, inhibited IL-6 and VEGF production (35+/-4% and 26+/-2%, respectively) but enhanced M-CSF production (38+/-4%) by IL-1beta (1 ng ml(-1)) in synovial fibroblasts isolated from patients with osteoarthritis (OA) and rheumatoid arthritis (RA).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	172-180
12010778-5	2002	Exogenous PGE(2) completely abolished the effects of NS-398 on the production of each mediator by OA fibroblasts stimulated with IL-1beta.	Dinoprostone	10-16	interleukin 1 beta	Homo sapiens	129-137
12010778-5	2002	Exogenous PGE(2) completely abolished the effects of NS-398 on the production of each mediator by OA fibroblasts stimulated with IL-1beta.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	53-59	interleukin 1 beta	Homo sapiens	129-137
12010778-14	2002	These results suggest that endogenous PGE(2) regulates the production of IL-6, M-CSF, and VEGF by IL-1beta-stimulated human synovial fibroblasts through the activation of EP(2) and EP(4) receptors with increase in cyclic AMP.	Prostaglandins E	38-41	interleukin 1 beta	Homo sapiens	98-106
12010778-14	2002	These results suggest that endogenous PGE(2) regulates the production of IL-6, M-CSF, and VEGF by IL-1beta-stimulated human synovial fibroblasts through the activation of EP(2) and EP(4) receptors with increase in cyclic AMP.	Cyclic AMP	214-224	interleukin 1 beta	Homo sapiens	98-106
12054592-3	2002	Furthermore, selective inhibition of NF-kappa B by the action of caffeic acid phenylethyl ester (CAPE; 1-100 microM) and sulfasalazine (SSA; 0.1-10 mM), a potent and irreversible inhibitor of NF-kappa B, partially attenuated but did not abolish LPS-dependent IL-1 beta secretion.	Sulfasalazine	121-134	interleukin 1 beta	Homo sapiens	259-268
12063092-6	2002	Arachidonic acid release in response to bradykinin was markedly enhanced by prior incubation with interleukin-1 beta and this was prevented by the prior addition of dexamethasone.	Arachidonic Acid	0-16	interleukin 1 beta	Homo sapiens	98-116
12063092-6	2002	Arachidonic acid release in response to bradykinin was markedly enhanced by prior incubation with interleukin-1 beta and this was prevented by the prior addition of dexamethasone.	Dexamethasone	165-178	interleukin 1 beta	Homo sapiens	98-116
11911993-1	2002	This study examines immediate nitric oxide (NO) release from monocytes following interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) challenge in patients with complex regional pain syndrome (CRPS).	Nitric Oxide	30-42	interleukin 1 beta	Homo sapiens	81-98
11911993-1	2002	This study examines immediate nitric oxide (NO) release from monocytes following interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) challenge in patients with complex regional pain syndrome (CRPS).	Nitric Oxide	30-42	interleukin 1 beta	Homo sapiens	100-108
12009845-5	2002	The addition of IL-1 beta, TNF-alpha, and IFN-gamma together increased nitrite production: 257.5 +/- 35.8 % and S-nitrosothiol production : 413 +/- 29%, P &lt; 0.001.	Nitrites	71-78	interleukin 1 beta	Homo sapiens	16-25
12009845-5	2002	The addition of IL-1 beta, TNF-alpha, and IFN-gamma together increased nitrite production: 257.5 +/- 35.8 % and S-nitrosothiol production : 413 +/- 29%, P &lt; 0.001.	S-Nitrosothiols	112-126	interleukin 1 beta	Homo sapiens	16-25
11801594-5	2002	Our studies show that HSF1 represses the lipopolyliposaccharide-induced transcription of the IL-1beta promoter through direct interaction with the nuclear factor of interleukin 6 (NF-IL6, also known as CCAAT enhancer binding protein (C/EBPbeta), an essential regulator in IL-1beta transcription.	lipopolyliposaccharide	41-63	interleukin 1 beta	Homo sapiens	93-101
12020636-9	2002	Other pro-inflammatory cytokines such as IL-1 beta and IL-6 were similarly decreased by CLA treatment of RAW cells.	Linoleic Acids, Conjugated	88-91	interleukin 1 beta	Homo sapiens	41-50
11801594-5	2002	Our studies show that HSF1 represses the lipopolyliposaccharide-induced transcription of the IL-1beta promoter through direct interaction with the nuclear factor of interleukin 6 (NF-IL6, also known as CCAAT enhancer binding protein (C/EBPbeta), an essential regulator in IL-1beta transcription.	lipopolyliposaccharide	41-63	interleukin 1 beta	Homo sapiens	272-280
12079021-0	2002	Inhibition of polymethylmethacrylate particle-induced monocyte activation and IL-1beta and TNF-alpha expression by the antioxidant agent N-acetylcysteine.	Acetylcysteine	137-153	interleukin 1 beta	Homo sapiens	78-86
12079021-6	2002	NAC treatment reduced TNFalpha and IL-1beta expression by the monocyte-macrophages.	Acetylcysteine	0-3	interleukin 1 beta	Homo sapiens	35-43
11888519-3	2002	When HAEC were pretreated with HCY followed by stimulation with IL-1 beta, U937 and Jurkat T-cell adhesion to HAEC increased in a dose-dependent manner.	Homocysteine	31-34	interleukin 1 beta	Homo sapiens	64-73
11934726-6	2002	Patients treated with methylprednisolone had progressive and sustained reductions of TNF-alpha, IL-1beta, IL-6, ACTH, and cortisol concentrations over time.	Methylprednisolone	22-40	interleukin 1 beta	Homo sapiens	96-104
11934726-7	2002	Normal PBL exposed to plasma samples collected during methylprednisolone exhibited significant progressive increases in all aspects of GR-mediated activity and significant reductions in NF-kappaB DNA-binding and transcription of TNF-alpha and IL-1beta.	Methylprednisolone	54-72	interleukin 1 beta	Homo sapiens	243-251
11926949-15	2002	CONCLUSION: In patients with UC, IL-1 beta was increased in colonic circular muscles and may contribute to motor dysfunction after UC through production of hydrogen peroxide.	Hydrogen Peroxide	156-173	interleukin 1 beta	Homo sapiens	33-42
12062366-5	2002	RESULTS: Nitrite accumulation in the myoblast culture supernatant or iNOS protein in the cell pellet was significantly increased after incubation with IL-1beta in combination with gamma-IFN.	Nitrites	9-16	interleukin 1 beta	Homo sapiens	151-159
11934803-12	2002	Budesonide inhibited IL-1beta-induced SCF mRNA expression (-68%) at 2.5 h and even more so at 10 h (-192%) (P&lt;0.001).	Budesonide	0-10	interleukin 1 beta	Homo sapiens	21-29
11934803-17	2002	Budesonide decreased this IL-1beta-enhanced stability by about 1.5-fold (P&lt;0.001).	Budesonide	0-10	interleukin 1 beta	Homo sapiens	26-34
11994141-5	2002	In contrast, lesional skin exposed to RA showed an almost 90% increase in CRBPI transcripts but unaltered expression of CRABPI and CRABPII, yet, the mRNA expression of several inflammatory mediators, e.g. inducible nitric oxide synthase, interferon-gamma and interleukin-1beta, was clearly reduced.	Radium	38-40	interleukin 1 beta	Homo sapiens	259-276
11897677-3	2002	The dsRNA, tested as synthetic poly(IC) (PIC), in synergism with the proinflammatory cytokines interferon-gamma (IFN-gamma) and/or IL-1 beta, results in nitric oxide production, Fas expression, beta-cell dysfunction, and death.	Nitric Oxide	153-165	interleukin 1 beta	Homo sapiens	131-140
12101082-4	2002	In addition, analysis of the mode of action of IL-1 beta revealed a novel induction of intracellular ROS, including hydrogen peroxide (H(2)O(2)), the superoxide anion (O(2)(-*)) and the hydroxyl radical (*OH).	Hydroxyl Radical	186-202	interleukin 1 beta	Homo sapiens	47-56
12101082-5	2002	The antioxidants, dimethyl sulfoxide (DMSO) and 1,3-dimethyl-2-thiourea (DMTU), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose-dependent manner, IL-1 beta-induced HIF-1 alpha nuclear translocation and activation.	Dimethyl Sulfoxide	18-36	interleukin 1 beta	Homo sapiens	177-186
12101082-5	2002	The antioxidants, dimethyl sulfoxide (DMSO) and 1,3-dimethyl-2-thiourea (DMTU), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose-dependent manner, IL-1 beta-induced HIF-1 alpha nuclear translocation and activation.	Dimethyl Sulfoxide	38-42	interleukin 1 beta	Homo sapiens	177-186
12101082-5	2002	The antioxidants, dimethyl sulfoxide (DMSO) and 1,3-dimethyl-2-thiourea (DMTU), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose-dependent manner, IL-1 beta-induced HIF-1 alpha nuclear translocation and activation.	1,3-dimethylthiourea	48-71	interleukin 1 beta	Homo sapiens	177-186
12101082-5	2002	The antioxidants, dimethyl sulfoxide (DMSO) and 1,3-dimethyl-2-thiourea (DMTU), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose-dependent manner, IL-1 beta-induced HIF-1 alpha nuclear translocation and activation.	1,3-dimethylthiourea	73-77	interleukin 1 beta	Homo sapiens	177-186
12101082-6	2002	The NADPH-oxidase inhibitor, 4"-hydroxy-3"-methoxy-acetophenone (HMAP), which may affect mitochondrial ROS production, attenuated IL-1 beta-mediated nuclear translocation and activation of HIF-1 alpha.	acetovanillone	29-63	interleukin 1 beta	Homo sapiens	130-139
12101082-6	2002	The NADPH-oxidase inhibitor, 4"-hydroxy-3"-methoxy-acetophenone (HMAP), which may affect mitochondrial ROS production, attenuated IL-1 beta-mediated nuclear translocation and activation of HIF-1 alpha.	acetovanillone	65-69	interleukin 1 beta	Homo sapiens	130-139
12101082-6	2002	The NADPH-oxidase inhibitor, 4"-hydroxy-3"-methoxy-acetophenone (HMAP), which may affect mitochondrial ROS production, attenuated IL-1 beta-mediated nuclear translocation and activation of HIF-1 alpha.	Reactive Oxygen Species	103-106	interleukin 1 beta	Homo sapiens	130-139
12101082-7	2002	Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate-dependent oxidase by diphenylene iodonium (DPI), which blocks the conversion of ubiquinone --&gt; ubiquinol, abrogated IL-1 beta-dependent nuclear translocation and activation of HIF-1 alpha.	diphenyleneiodonium	107-127	interleukin 1 beta	Homo sapiens	205-214
12101082-7	2002	Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate-dependent oxidase by diphenylene iodonium (DPI), which blocks the conversion of ubiquinone --&gt; ubiquinol, abrogated IL-1 beta-dependent nuclear translocation and activation of HIF-1 alpha.	diphenyleneiodonium	129-132	interleukin 1 beta	Homo sapiens	205-214
12101082-7	2002	Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate-dependent oxidase by diphenylene iodonium (DPI), which blocks the conversion of ubiquinone --&gt; ubiquinol, abrogated IL-1 beta-dependent nuclear translocation and activation of HIF-1 alpha.	Ubiquinone	166-176	interleukin 1 beta	Homo sapiens	205-214
12101082-7	2002	Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate-dependent oxidase by diphenylene iodonium (DPI), which blocks the conversion of ubiquinone --&gt; ubiquinol, abrogated IL-1 beta-dependent nuclear translocation and activation of HIF-1 alpha.	ubiquinol	184-193	interleukin 1 beta	Homo sapiens	205-214
12101082-8	2002	Similarly, interrupting the respiratory chain with potassium cyanide reversed the excitatory effect of IL-1 beta on HIF-1 alpha nuclear translocation and activation.	Potassium Cyanide	51-68	interleukin 1 beta	Homo sapiens	103-112
12133311-1	2002	OBJECTIVE: To investigate the effect of polysaccharide sulfate 916 (PS916) on the production of nitric oxide (NO) in ECV304 cells induced by tumor necrosis factor-alpha (TNF alpha), interleukin-1 beta (IL-1 beta) and H(2)O(2) in vitro.	polysaccharide sulfate	40-62	interleukin 1 beta	Homo sapiens	182-200
12101082-0	2002	Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism.	Reactive Oxygen Species	188-211	interleukin 1 beta	Homo sapiens	18-41
12101082-0	2002	Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism.	Reactive Oxygen Species	213-216	interleukin 1 beta	Homo sapiens	18-41
12101082-2	2002	Furthermore, evidence that reactive oxygen species (ROS) signaling mediates interleukin (IL)-1 beta-dependent regulation of HIF-1 alpha has yet to be ascertained in alveolar epithelial cells.	Reactive Oxygen Species	27-50	interleukin 1 beta	Homo sapiens	76-99
12101082-2	2002	Furthermore, evidence that reactive oxygen species (ROS) signaling mediates interleukin (IL)-1 beta-dependent regulation of HIF-1 alpha has yet to be ascertained in alveolar epithelial cells.	Reactive Oxygen Species	52-55	interleukin 1 beta	Homo sapiens	76-99
12101082-4	2002	In addition, analysis of the mode of action of IL-1 beta revealed a novel induction of intracellular ROS, including hydrogen peroxide (H(2)O(2)), the superoxide anion (O(2)(-*)) and the hydroxyl radical (*OH).	Reactive Oxygen Species	101-104	interleukin 1 beta	Homo sapiens	47-56
12101082-4	2002	In addition, analysis of the mode of action of IL-1 beta revealed a novel induction of intracellular ROS, including hydrogen peroxide (H(2)O(2)), the superoxide anion (O(2)(-*)) and the hydroxyl radical (*OH).	Hydrogen Peroxide	116-133	interleukin 1 beta	Homo sapiens	47-56
12101082-4	2002	In addition, analysis of the mode of action of IL-1 beta revealed a novel induction of intracellular ROS, including hydrogen peroxide (H(2)O(2)), the superoxide anion (O(2)(-*)) and the hydroxyl radical (*OH).	Hydrogen Peroxide	135-143	interleukin 1 beta	Homo sapiens	47-56
12101082-4	2002	In addition, analysis of the mode of action of IL-1 beta revealed a novel induction of intracellular ROS, including hydrogen peroxide (H(2)O(2)), the superoxide anion (O(2)(-*)) and the hydroxyl radical (*OH).	Superoxides	150-166	interleukin 1 beta	Homo sapiens	47-56
12034023-5	2002	Macrophage functions, such as production of superoxide anion and phagocytosis, also were stimulated by IL-1beta gene injection.	Superoxides	44-60	interleukin 1 beta	Homo sapiens	103-111
11854037-8	2002	Treatment of the cells with PD-98059 inhibited the IL-1beta-induced increase in beta and delta activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	28-36	interleukin 1 beta	Homo sapiens	51-59
11835156-7	2002	DMAEMA (1.6- 6.4 mM) virtually eliminated the acute IL-6 response of these cells to an interleukin-1beta challenge; only at 0.32 mM DMAEMA was the response restored.	2-(dimethylamino)ethyl methacrylate	0-6	interleukin 1 beta	Homo sapiens	87-104
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	12-21	interleukin 1 beta	Homo sapiens	144-152
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	23-55	interleukin 1 beta	Homo sapiens	144-152
12034025-5	2002	Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression.	Capsaicin	33-42	interleukin 1 beta	Homo sapiens	84-92
11936556-5	2002	Antipyretic drugs such as acetylsalicylic acid, dexamethasone, and lipocortin 5-(204-212) peptide counteract IL-1beta-induced fever and abolish changes in Ca2+ and PGE2 concentrations in CSF.	Aspirin	26-46	interleukin 1 beta	Homo sapiens	109-117
11950021-10	2002	ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects.	aceclofenac	0-6	interleukin 1 beta	Homo sapiens	59-67
11950021-10	2002	ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects.	Indomethacin	15-19	interleukin 1 beta	Homo sapiens	59-67
11950021-10	2002	ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects.	nimesulide	21-24	interleukin 1 beta	Homo sapiens	59-67
11950021-10	2002	ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects.	Celecoxib	96-100	interleukin 1 beta	Homo sapiens	125-133
11936556-0	2002	Role of the nitric oxide/cyclic GMP/Ca2+ signaling pathway in the pyrogenic effect of interleukin-1beta.	Nitric Oxide	12-24	interleukin 1 beta	Homo sapiens	86-103
11950021-10	2002	ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects.	Ibuprofen	105-109	interleukin 1 beta	Homo sapiens	125-133
11936556-0	2002	Role of the nitric oxide/cyclic GMP/Ca2+ signaling pathway in the pyrogenic effect of interleukin-1beta.	Cyclic GMP	25-35	interleukin 1 beta	Homo sapiens	86-103
11936556-5	2002	Antipyretic drugs such as acetylsalicylic acid, dexamethasone, and lipocortin 5-(204-212) peptide counteract IL-1beta-induced fever and abolish changes in Ca2+ and PGE2 concentrations in CSF.	Dexamethasone	48-61	interleukin 1 beta	Homo sapiens	109-117
11936556-5	2002	Antipyretic drugs such as acetylsalicylic acid, dexamethasone, and lipocortin 5-(204-212) peptide counteract IL-1beta-induced fever and abolish changes in Ca2+ and PGE2 concentrations in CSF.	lipocortin 5	67-79	interleukin 1 beta	Homo sapiens	109-117
11936556-5	2002	Antipyretic drugs such as acetylsalicylic acid, dexamethasone, and lipocortin 5-(204-212) peptide counteract IL-1beta-induced fever and abolish changes in Ca2+ and PGE2 concentrations in CSF.	Dinoprostone	164-168	interleukin 1 beta	Homo sapiens	109-117
11936556-6	2002	In vitro studies have established that activation of the nitric oxide (NO)/cyclic GMP (cGMP) pathway is part of the signaling cascade transducing Ca2+ mobilization in response to IL-1beta and that the ryanodine (RY)- and inositol-(1,4,5)-trisphosphate (IP3)-sensitive pools are the main source of the mobilized Ca2+.	Nitric Oxide	57-69	interleukin 1 beta	Homo sapiens	179-187
11936556-6	2002	In vitro studies have established that activation of the nitric oxide (NO)/cyclic GMP (cGMP) pathway is part of the signaling cascade transducing Ca2+ mobilization in response to IL-1beta and that the ryanodine (RY)- and inositol-(1,4,5)-trisphosphate (IP3)-sensitive pools are the main source of the mobilized Ca2+.	Cyclic GMP	75-85	interleukin 1 beta	Homo sapiens	179-187
11936556-6	2002	In vitro studies have established that activation of the nitric oxide (NO)/cyclic GMP (cGMP) pathway is part of the signaling cascade transducing Ca2+ mobilization in response to IL-1beta and that the ryanodine (RY)- and inositol-(1,4,5)-trisphosphate (IP3)-sensitive pools are the main source of the mobilized Ca2+.	Cyclic GMP	87-91	interleukin 1 beta	Homo sapiens	179-187
11936556-7	2002	It is concluded that the NO/cGMP/Ca2+ pathway is part of the signaling cascade subserving some of the multiple functions of IL-1beta.	Cyclic GMP	28-32	interleukin 1 beta	Homo sapiens	124-132
11930180-0	2002	Interleukin-1 beta is involved in the pressor response of amygdaloid neurons excited by sodium glutamate.	Sodium Glutamate	88-104	interleukin 1 beta	Homo sapiens	0-18
11872267-0	2002	Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid beta peptide and interleukin-1beta.	Water	0-5	interleukin 1 beta	Homo sapiens	141-158
11872267-0	2002	Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid beta peptide and interleukin-1beta.	Chitosan	14-22	interleukin 1 beta	Homo sapiens	141-158
11930180-3	2002	Microinjection of interleukin-1beta into paraventricular nucleus or caudal arcuate nucleus induced significant pressor and tachycardiac responses while pretreatment with microinjection of rabbit anti-rat interleukin-1beta antibody into bilateral paraventricular nuclei or arcuate nuclei attenuated the hypertensive response induced by microinjection of 40 nmol sodium glutamate into central amygdaloid nucleus.	Sodium Glutamate	361-377	interleukin 1 beta	Homo sapiens	18-35
11867742-7	2002	Human peripheral blood mononuclear cells stimulated with LPS in the presence of SAHA released less TNF-alpha, IL-1-beta, IL-12, and IFN-gamma (50% reduction at 100-200 nM).	Vorinostat	80-84	interleukin 1 beta	Homo sapiens	110-119
11998897-4	2002	We show here, using IL-1alpha stimulation to simulate autoinduction, that administration of GLA to healthy volunteers and to patients with inflammatory arthritis reduces LPS-induced IL-1beta secretion mainly by reducing autoinduction of IL-1beta.	gamma-Linolenic Acid	92-95	interleukin 1 beta	Homo sapiens	182-190
11853544-6	2002	SB203580, a selective p38 mitogen-activated protein kinase (MAPK) inhibitor, completely abolished the IL-1beta-induced COX-2 mRNA.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	102-110
11998897-0	2002	Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes.	gamma-Linolenic Acid	23-42	interleukin 1 beta	Homo sapiens	115-132
11998897-0	2002	Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes.	Fatty Acids, Unsaturated	47-69	interleukin 1 beta	Homo sapiens	115-132
11998897-4	2002	We show here, using IL-1alpha stimulation to simulate autoinduction, that administration of GLA to healthy volunteers and to patients with inflammatory arthritis reduces LPS-induced IL-1beta secretion mainly by reducing autoinduction of IL-1beta.	gamma-Linolenic Acid	92-95	interleukin 1 beta	Homo sapiens	237-245
11998897-2	2002	Addition of GLA in vitro suppresses release of interleukin-1beta (IL-1beta) from human monocytes stimulated with lipopolysaccharide (LPS).	gamma-Linolenic Acid	12-15	interleukin 1 beta	Homo sapiens	47-64
11998897-5	2002	GLA reduces LPS-induced pro-IL-1beta mRNA modestly and IL-la-induced pro-IL-1beta gene expression markedly.	gamma-Linolenic Acid	0-3	interleukin 1 beta	Homo sapiens	28-36
11998897-2	2002	Addition of GLA in vitro suppresses release of interleukin-1beta (IL-1beta) from human monocytes stimulated with lipopolysaccharide (LPS).	gamma-Linolenic Acid	12-15	interleukin 1 beta	Homo sapiens	66-74
11998897-6	2002	In addition to reducing amplification of IL-1beta, GLA increases the amount of IL-1 receptor antagonist (IL-1Ra) secreted from stimulated cells, thereby facilitating an increase in the secreted IL-1Ra/IL-1beta ratio.	gamma-Linolenic Acid	51-54	interleukin 1 beta	Homo sapiens	201-209
11908571-0	2002	Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.	Eicosanoids	101-111	interleukin 1 beta	Homo sapiens	13-59
11908571-4	2002	The effect of endogenous eicosanoids on basal and induced levels of IL-1beta, TNF-alpha, and MMP-1 synthesis was examined by incubating explants in the presence of NS-398 and Bay-x-1005.	Eicosanoids	25-36	interleukin 1 beta	Homo sapiens	68-76
11908571-10	2002	Basal and LIT induced IL-1beta and TNF-alpha production were inhibited by Bay-x-1005 in a dose dependent manner, while the addition of NS-398 caused a potent stimulatory effect.	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid	74-84	interleukin 1 beta	Homo sapiens	22-30
11854442-3	2002	We found that the stimulation of WISH cells with interleukin (IL)-1 beta elicited dose-dependent synthesis of cyclooxygenase-2 (COX-2) mRNA, protein, and their products, PGE(2).	Prostaglandins E	170-173	interleukin 1 beta	Homo sapiens	49-72
11882700-3	2002	This study shows that treatment of human intestinal epithelial T84 cells with Etx induces expression of IL-6, IL-10, IL-1R antagonist, as well as IL-1alpha and IL-1beta and low levels of IL-8.	2-ethoxyethanol	78-81	interleukin 1 beta	Homo sapiens	160-168
11870236-2	2002	We have therefore investigated the effects of a cytokine-suppressant anti-inflammatory drug (CSAID) on the output of prostaglandin E(2) (PGE(2)) and interleukin (IL)-1 beta from human fetal membranes in vitro.	csaid	93-98	interleukin 1 beta	Homo sapiens	149-172
11867828-6	2002	RESULTS: Formoterol exerted an additive effect on the inhibition of IL-1beta stimulated ICAM-1 and VCAM-1 upregulation and GM-CSF production by budesonide in concentrations of 10(-9) M and above (p&lt;0.05).	Formoterol Fumarate	9-19	interleukin 1 beta	Homo sapiens	68-76
11867828-6	2002	RESULTS: Formoterol exerted an additive effect on the inhibition of IL-1beta stimulated ICAM-1 and VCAM-1 upregulation and GM-CSF production by budesonide in concentrations of 10(-9) M and above (p&lt;0.05).	Budesonide	144-154	interleukin 1 beta	Homo sapiens	68-76
11854442-5	2002	Pretreating the cells with 1-butanol and Ro 31-8220 inhibited the IL-1 beta-induced COX-2 expression, but 3-butanol did not affect this response.	1-Butanol	27-36	interleukin 1 beta	Homo sapiens	66-75
11854442-6	2002	In addition, evidence that PLD was involved in the stimulation of COX-2 expression was provided by the observations that COX-2 expression was stimulated by the dioctanoyl phosphatidic acid (PA) and that the prevention of PA dephosphorylation by 1-propranolol potentiated COX-2 expression by IL-1 beta.	Phosphatidic Acids	221-223	interleukin 1 beta	Homo sapiens	291-300
11823535-10	2002	Transfection studies using Spi-1 mutant constructs showed that the TATA-binding protein binding and glutamine-rich domains of Spi-1 were important for IL-1beta induction, whereas LPS induction required the proline, glutamic acid, serine, and threonine-rich domain containing serine 148 as well as the TATA-binding protein and glutamine-rich domains.	Glutamine	100-109	interleukin 1 beta	Homo sapiens	151-159
11823535-10	2002	Transfection studies using Spi-1 mutant constructs showed that the TATA-binding protein binding and glutamine-rich domains of Spi-1 were important for IL-1beta induction, whereas LPS induction required the proline, glutamic acid, serine, and threonine-rich domain containing serine 148 as well as the TATA-binding protein and glutamine-rich domains.	Serine	275-281	interleukin 1 beta	Homo sapiens	151-159
11823535-10	2002	Transfection studies using Spi-1 mutant constructs showed that the TATA-binding protein binding and glutamine-rich domains of Spi-1 were important for IL-1beta induction, whereas LPS induction required the proline, glutamic acid, serine, and threonine-rich domain containing serine 148 as well as the TATA-binding protein and glutamine-rich domains.	Serine	230-236	interleukin 1 beta	Homo sapiens	151-159
11823535-10	2002	Transfection studies using Spi-1 mutant constructs showed that the TATA-binding protein binding and glutamine-rich domains of Spi-1 were important for IL-1beta induction, whereas LPS induction required the proline, glutamic acid, serine, and threonine-rich domain containing serine 148 as well as the TATA-binding protein and glutamine-rich domains.	Glutamine	326-335	interleukin 1 beta	Homo sapiens	151-159
11823535-10	2002	Transfection studies using Spi-1 mutant constructs showed that the TATA-binding protein binding and glutamine-rich domains of Spi-1 were important for IL-1beta induction, whereas LPS induction required the proline, glutamic acid, serine, and threonine-rich domain containing serine 148 as well as the TATA-binding protein and glutamine-rich domains.	Threonine	242-251	interleukin 1 beta	Homo sapiens	151-159
11840449-7	2002	The ability of dexamethasone and ASA to suppress IFNgamma and interleukin-1beta (IL-1beta) messenger RNA and protein production was also tested in vitro using T cell clones and monocytes derived from patients with GCA.	Dexamethasone	15-28	interleukin 1 beta	Homo sapiens	62-79
11866531-4	2002	Sequence analysis of interleukin-1beta indicates that three phenylalanine residues located at positions 42, 101, and 146 are well conserved, separated by approximately 50 residues in the primary sequence, located in similar positions in the pseudo-symmetric units of the trefoil, and are juxtaposed to one another in conformational space.	Phenylalanine	60-73	interleukin 1 beta	Homo sapiens	21-38
11840449-7	2002	The ability of dexamethasone and ASA to suppress IFNgamma and interleukin-1beta (IL-1beta) messenger RNA and protein production was also tested in vitro using T cell clones and monocytes derived from patients with GCA.	Dexamethasone	15-28	interleukin 1 beta	Homo sapiens	81-89
11840449-7	2002	The ability of dexamethasone and ASA to suppress IFNgamma and interleukin-1beta (IL-1beta) messenger RNA and protein production was also tested in vitro using T cell clones and monocytes derived from patients with GCA.	Aspirin	33-36	interleukin 1 beta	Homo sapiens	62-79
11840449-7	2002	The ability of dexamethasone and ASA to suppress IFNgamma and interleukin-1beta (IL-1beta) messenger RNA and protein production was also tested in vitro using T cell clones and monocytes derived from patients with GCA.	Aspirin	33-36	interleukin 1 beta	Homo sapiens	81-89
11830551-4	2002	Culture supernatants from both cell lines induced NF-kappaB activity in chemosensitive PT45-P1 pancreatic carcinoma cells and significantly attenuated etoposide-induced apoptosis in a NF-kappaB-dependent fashion, similar to that seen in PT45-P1 cells treated with recombinant IL-1beta.	Etoposide	151-160	interleukin 1 beta	Homo sapiens	276-284
11834608-4	2002	IL-1beta-induced chondrocyte products (nitric oxide and prostaglandin E(2)) were measured in culture supernatants after 48 h incubation time.	Nitric Oxide	39-51	interleukin 1 beta	Homo sapiens	0-8
11834608-4	2002	IL-1beta-induced chondrocyte products (nitric oxide and prostaglandin E(2)) were measured in culture supernatants after 48 h incubation time.	Dinoprostone	56-74	interleukin 1 beta	Homo sapiens	0-8
11834608-7	2002	The selective PDE4 inhibitors Piclamilast and Roflumilast partially attenuated IL-1beta-induced NO production whereas selective inhibitors of PDE2 (EHNA), PDE3 (Motapizone) or PDE5 (Sildenafil) were inactive.	piclamilast	30-41	interleukin 1 beta	Homo sapiens	79-87
11834608-7	2002	The selective PDE4 inhibitors Piclamilast and Roflumilast partially attenuated IL-1beta-induced NO production whereas selective inhibitors of PDE2 (EHNA), PDE3 (Motapizone) or PDE5 (Sildenafil) were inactive.	Roflumilast	46-57	interleukin 1 beta	Homo sapiens	79-87
11834608-8	2002	Indomethacin reversed the reduction of IL-1beta-induced NO by PDE4 inhibitors.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	39-47
11834608-9	2002	It was shown that autocrine prostaglandin E(2) (PGE(2)) enabled PDE4 inhibitors to reduce IL-1beta-induced NO in this experimental setting.	Dinoprostone	28-46	interleukin 1 beta	Homo sapiens	90-98
11834608-9	2002	It was shown that autocrine prostaglandin E(2) (PGE(2)) enabled PDE4 inhibitors to reduce IL-1beta-induced NO in this experimental setting.	Dinoprostone	48-54	interleukin 1 beta	Homo sapiens	90-98
11834608-1	2002	We studied whether selective inhibitors of cyclic nucleotide hydrolysing phosphodiesterase (PDE) isoenzymes influence IL-1beta-induced nitric oxide (NO) release from human articular chondrocytes.	Nucleotides, Cyclic	43-60	interleukin 1 beta	Homo sapiens	118-126
11834608-1	2002	We studied whether selective inhibitors of cyclic nucleotide hydrolysing phosphodiesterase (PDE) isoenzymes influence IL-1beta-induced nitric oxide (NO) release from human articular chondrocytes.	Nitric Oxide	135-147	interleukin 1 beta	Homo sapiens	118-126
11830551-8	2002	Blockade of NF-kappaB activation by MG132, sulfasalazine, or an IkappaBalpha superrepressor disrupted the IL-1beta-mediated amplification loop and the accompanying chemoresistance.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	36-41	interleukin 1 beta	Homo sapiens	106-114
11830551-8	2002	Blockade of NF-kappaB activation by MG132, sulfasalazine, or an IkappaBalpha superrepressor disrupted the IL-1beta-mediated amplification loop and the accompanying chemoresistance.	Sulfasalazine	43-56	interleukin 1 beta	Homo sapiens	106-114
12022438-0	2002	1 alpha,25-dihydroxyvitamin D3 suppresses interleukin-1beta-induced interleukin-8 production in human whole blood: an involvement of erythrocytes in the inhibition.	Calcitriol	0-30	interleukin 1 beta	Homo sapiens	42-59
11876744-0	2002	Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells.	Lidocaine	0-9	interleukin 1 beta	Homo sapiens	41-49
11876744-8	2002	Lidocaine, in therapeutic concentrations, inhibited the spontaneous and TNFalpha-stimulated secretion of IL-8 and IL-1beta from HT-29 and Caco-2 cell lines in a dose-dependent manner.	Lidocaine	0-9	interleukin 1 beta	Homo sapiens	114-122
12022438-8	2002	These results suggest that erythrocytes play a role in mediating the inhibitory effects of 1,25(OH)2D3 on IL-8 production in IL-1beta-stimulated whole blood.	Calcitriol	91-102	interleukin 1 beta	Homo sapiens	125-133
11846460-7	2002	The production of IL-1beta, IL-6, and IL-8 was also decreased in LPS-activated adherent monocytes by Tau-Cl.	N-chlorotaurine	101-107	interleukin 1 beta	Homo sapiens	18-26
11882577-1	2002	Interleukin-1beta (IL-1beta), a proinflammatory cytokine, induces cyclooxygenase-2 (COX-2) in cultured neonatal ventricular myocytes (NVMs), resulting in the preferential production of prostaglandin E(2) (PGE(2)).	Dinoprostone	185-203	interleukin 1 beta	Homo sapiens	0-17
11882577-1	2002	Interleukin-1beta (IL-1beta), a proinflammatory cytokine, induces cyclooxygenase-2 (COX-2) in cultured neonatal ventricular myocytes (NVMs), resulting in the preferential production of prostaglandin E(2) (PGE(2)).	Dinoprostone	185-203	interleukin 1 beta	Homo sapiens	19-27
11882577-1	2002	Interleukin-1beta (IL-1beta), a proinflammatory cytokine, induces cyclooxygenase-2 (COX-2) in cultured neonatal ventricular myocytes (NVMs), resulting in the preferential production of prostaglandin E(2) (PGE(2)).	Prostaglandins E	205-208	interleukin 1 beta	Homo sapiens	0-17
11882577-1	2002	Interleukin-1beta (IL-1beta), a proinflammatory cytokine, induces cyclooxygenase-2 (COX-2) in cultured neonatal ventricular myocytes (NVMs), resulting in the preferential production of prostaglandin E(2) (PGE(2)).	Prostaglandins E	205-208	interleukin 1 beta	Homo sapiens	19-27
12022439-2	2002	Chlorogenic acid, a plant polyphenol, inhibited SE-induced T-cell proliferation (by 98%) and production of interleukin 1beta, tumor necrosis factor, interleukin 6, interferon gamma, monocyte chemotactic protein I (MCP-l), macrophage inflammatory protein (MIP)-lalpha, and MIP-lbeta by human peripheral blood mononuclear cells.	Chlorogenic Acid	0-16	interleukin 1 beta	Homo sapiens	107-124
11869069-10	2002	Interestingly, 15d-PGJ(2) reduced both basal and IL-1beta-induced AP-1 binding activity.	15d-pgj	15-22	interleukin 1 beta	Homo sapiens	49-57
11911801-8	2002	In addition, the specificity of this inhibition was demonstrated by the inability of herbimycin-A to block in a significant manner IL-1 beta induction of CXCL-8.	herbimycin	85-97	interleukin 1 beta	Homo sapiens	131-140
11842936-3	2002	Indomethacin, a cyclooxygenase inhibitor, significantly enhanced IL-1beta-induced IL-6 production by HGF, although it completely inhibited IL-1beta-induced PGE2 production.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	65-73
11842936-3	2002	Indomethacin, a cyclooxygenase inhibitor, significantly enhanced IL-1beta-induced IL-6 production by HGF, although it completely inhibited IL-1beta-induced PGE2 production.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	139-147
11842936-3	2002	Indomethacin, a cyclooxygenase inhibitor, significantly enhanced IL-1beta-induced IL-6 production by HGF, although it completely inhibited IL-1beta-induced PGE2 production.	Dinoprostone	156-160	interleukin 1 beta	Homo sapiens	139-147
11842936-4	2002	Exogenous PGE2 suppressed the IL-1beta-induced IL-6 production.	Dinoprostone	10-14	interleukin 1 beta	Homo sapiens	30-38
11842936-6	2002	11-deoxy-PGE1, a selective EP2/EP3/EP4 agonist, and butaprost, a selective EP2 agonist, inhibited IL-1beta-induced IL-6 production, although butaprost was less potent than 11-deoxy-PGE1.	11-deoxyprostaglandin E1	0-13	interleukin 1 beta	Homo sapiens	98-106
11842936-6	2002	11-deoxy-PGE1, a selective EP2/EP3/EP4 agonist, and butaprost, a selective EP2 agonist, inhibited IL-1beta-induced IL-6 production, although butaprost was less potent than 11-deoxy-PGE1.	butaprost	52-61	interleukin 1 beta	Homo sapiens	98-106
11842936-7	2002	17-phenyl-omega-trinor PGE2, an EP1 agonist, enhanced IL-1beta-induced IL-6 production.	17-phenyltrinorprostaglandin E2	0-27	interleukin 1 beta	Homo sapiens	54-62
11842936-8	2002	Based on these data, we suggest that PGE2 can up- or downregulate IL-1beta-induced IL-6 production via EP1 receptors or via EP2/EP4 receptors in HGF, respectively.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	66-74
11818704-2	2002	In this prospective randomized study, we aimed to compare the effect of oral and intravenous (IV) pulse calcitriol on serum levels of IL-1 beta and IL-6.	Calcitriol	104-114	interleukin 1 beta	Homo sapiens	134-143
11818704-8	2002	Oral and IV calcitriol caused a significant fall in IL-1 beta (p = 0.02 and p = 0.03, respectively) and IL-6 levels (p = 0.02 and p &lt; 0.001, respectively) at the 6th month of treatment.	Calcitriol	12-22	interleukin 1 beta	Homo sapiens	52-61
11869069-7	2002	PPARgamma activators (15d-PGJ(2) and BRL 49653) inhibited IL-1beta-induced MMP-1 synthesis in a dose-dependent manner.	15d-pgj	22-29	interleukin 1 beta	Homo sapiens	58-66
11806708-3	2002	To address an unmet need for selective inhibitors of glial activation, we developed a novel 3-amino-6-phenylpyridazine derivative that selectively blocks increased IL-1 beta, iNOS, and NO production by activated glia, without inhibition of potentially beneficial glial functions.	6-phenylpyridazin-3-amine	92-118	interleukin 1 beta	Homo sapiens	164-173
12579952-5	2002	RESULTS: Meloxicam was found to effectively inhibit TNF-alpha (50 u.mL-1 for 12 h) and IL-1 beta (50 u.mL-1 for 12 h)-induced adhesion of PMN to HSC (IC50 3.38 x 10(-7) mol.L-1 and 3.56 x 10(-6) mol.L-1, respectively) in a concentration-dependent manner.	Meloxicam	9-18	interleukin 1 beta	Homo sapiens	87-96
11694529-8	2002	Finally, 1,4-dihydroquinone blocks the induction of TNF-alpha target genes interleukin 1beta and interleukin 6 at both mRNA and protein levels.	1,4-dihydroquinone	9-27	interleukin 1 beta	Homo sapiens	75-92
11777983-8	2002	Furthermore, IL-17, IL-1beta, and TNF-alpha induced a rapid activation of extracellular signal-related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors (SB203580, PD98059, and U0216) significantly reduced IL-17-, IL-1beta-, or TNF-alpha-induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6.	SB 203580	162-170	interleukin 1 beta	Homo sapiens	20-28
11777983-8	2002	Furthermore, IL-17, IL-1beta, and TNF-alpha induced a rapid activation of extracellular signal-related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors (SB203580, PD98059, and U0216) significantly reduced IL-17-, IL-1beta-, or TNF-alpha-induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	172-179	interleukin 1 beta	Homo sapiens	20-28
11777983-7	2002	EMSAs demonstrated that IL-17, IL-1beta, and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha-induced IL-6 gene expression.	pyrrolidine	162-173	interleukin 1 beta	Homo sapiens	31-39
11777983-7	2002	EMSAs demonstrated that IL-17, IL-1beta, and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha-induced IL-6 gene expression.	pyrrolidine	162-173	interleukin 1 beta	Homo sapiens	266-274
11777983-7	2002	EMSAs demonstrated that IL-17, IL-1beta, and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha-induced IL-6 gene expression.	Dithiocarbamate	188-203	interleukin 1 beta	Homo sapiens	31-39
11777983-7	2002	EMSAs demonstrated that IL-17, IL-1beta, and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha-induced IL-6 gene expression.	Dithiocarbamate	188-203	interleukin 1 beta	Homo sapiens	266-274
11777983-7	2002	EMSAs demonstrated that IL-17, IL-1beta, and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha-induced IL-6 gene expression.	tosyl-phe-chloromethylketone	208-236	interleukin 1 beta	Homo sapiens	31-39
11779159-4	2002	K562 cells treated with a combination of Lf and PMA showed a synergistic induction in the level of IL-1beta mRNA over treatment with PMA alone.	Tetradecanoylphorbol Acetate	48-51	interleukin 1 beta	Homo sapiens	99-107
11750956-4	2002	RESULTS: IL-1beta and TNF-alpha both stimulated production of PGE(2) and 6-keto-PGF(1alpha) in a concentration-dependent manner.	Prostaglandins E	62-65	interleukin 1 beta	Homo sapiens	9-17
11750956-4	2002	RESULTS: IL-1beta and TNF-alpha both stimulated production of PGE(2) and 6-keto-PGF(1alpha) in a concentration-dependent manner.	6-keto-pgf	73-83	interleukin 1 beta	Homo sapiens	9-17
11751204-4	2002	In this investigation we demonstrate that interferon (IFN)-gamma and interleukin (IL)-1beta have opposing effects on Fas-mediated apoptosis in A549 cells, a human lung epithelial cell line.	ammonium ferrous sulfate	117-120	interleukin 1 beta	Homo sapiens	69-91
11833742-3	2002	The migration distance of the quiescent VSMC induced by cytokines bFGF, IL-1beta and TNF-alpha was 5.8, 4.7, and 4.2 times as long as that of the control group, respectively.	vsmc	40-44	interleukin 1 beta	Homo sapiens	72-80
11751214-3	2002	Human bronchial epithelial cells stimulated with 50 ng/ml interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma express iNOS mRNA, protein and increased nitrite in the cell culture media, which was inhibited by the selective iNOS inhibitor 1400W.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	255-260	interleukin 1 beta	Homo sapiens	58-104
11677248-6	2002	To address the possibility that FN-f-induced NO release is mediated by IL-1beta production, the effect of IL-1 receptor antagonist (IL-1ra) was determined.	fn-f	32-36	interleukin 1 beta	Homo sapiens	71-79
11751211-5	2002	Exposure of alveolar epithelial cells to amiloride or its analog, 5-(N,N-hexamethylene)-amiloride (HMA), reduced, in a dose-dependent manner, lipopolysaccharide (LPS)-induced secretion of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	Amiloride	41-50	interleukin 1 beta	Homo sapiens	188-210
11751211-5	2002	Exposure of alveolar epithelial cells to amiloride or its analog, 5-(N,N-hexamethylene)-amiloride (HMA), reduced, in a dose-dependent manner, lipopolysaccharide (LPS)-induced secretion of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	5-(N,N-hexamethylene)amiloride	66-97	interleukin 1 beta	Homo sapiens	188-210
11751211-5	2002	Exposure of alveolar epithelial cells to amiloride or its analog, 5-(N,N-hexamethylene)-amiloride (HMA), reduced, in a dose-dependent manner, lipopolysaccharide (LPS)-induced secretion of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	5-(N,N-hexamethylene)amiloride	99-102	interleukin 1 beta	Homo sapiens	188-210
12436208-4	2002	In LPS-stimulated cells Tau-Cl inhibited both the secreted and cell-associated IL-1 beta and IL-6, while exerted dual effect on TNF- alpha production: raising it slightly at low and reducing at higher concentration.	tau-cl	24-30	interleukin 1 beta	Homo sapiens	79-88
11751214-3	2002	Human bronchial epithelial cells stimulated with 50 ng/ml interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma express iNOS mRNA, protein and increased nitrite in the cell culture media, which was inhibited by the selective iNOS inhibitor 1400W.	Nitrites	168-175	interleukin 1 beta	Homo sapiens	58-104
11792187-4	2002	Cells treated with IL-1 beta expressed E-selectin and showed a 100-200 times higher binding of CLIO particles (83-104 ng iron/million cells) than control cells.	Iron	121-125	interleukin 1 beta	Homo sapiens	19-28
11879548-3	2002	In combination with TNF or IL-1beta, hTWEAK further stimulated the secretion of prostaglandin E2, MMP-1, IL-6 and IL-8 up to fourfold, and IP-10 and RANTES up to 70-fold compared to TNF or IL-1beta alone.	Dinoprostone	80-96	interleukin 1 beta	Homo sapiens	27-35
12082286-5	2002	Moreover, in OA synovium, a relative deficit in the production of natural antagonists of the IL-1 receptor (IL-1Ra) has been demonstrated, and could possibly be related to an excess production of nitric oxide in OA tissues.	Nitric Oxide	196-208	interleukin 1 beta	Homo sapiens	93-97
12635495-10	2002	Thus, KE-758 inhibits both TNF-alpha and IL-1 beta production and its antirheumatic profile is apparently distinct from that of D-penicillamine, bucillamine and auranofin.	KE 758	6-12	interleukin 1 beta	Homo sapiens	41-50
12635495-0	2002	KE-758, an active metabolite of the new anti-rheumatic drug KE-298, suppresses production of tumor necrosis factor-alpha and interleukin-1 beta in THP-1, a human monocyte cell line.	KE 758	0-6	interleukin 1 beta	Homo sapiens	125-143
11835394-8	2002	The present results suggest that sodium arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1beta-stimulated Caco-2 cells independent of the heat shock response.	sodium arsenite	33-48	interleukin 1 beta	Homo sapiens	110-118
12635495-0	2002	KE-758, an active metabolite of the new anti-rheumatic drug KE-298, suppresses production of tumor necrosis factor-alpha and interleukin-1 beta in THP-1, a human monocyte cell line.	esonarimod	60-66	interleukin 1 beta	Homo sapiens	125-143
12635495-6	2002	KE-758 and auranofin but not D-penicillamine and bucillamine significantly suppressed both TNF-alpha and IL-1 beta.	KE 758	0-6	interleukin 1 beta	Homo sapiens	105-114
12635495-6	2002	KE-758 and auranofin but not D-penicillamine and bucillamine significantly suppressed both TNF-alpha and IL-1 beta.	Auranofin	11-20	interleukin 1 beta	Homo sapiens	105-114
12635495-7	2002	Auranofin suppressed IL-1 beta production by reducing cellular viability.	Auranofin	0-9	interleukin 1 beta	Homo sapiens	21-30
12635495-8	2002	Reverse transcriptase-polymerase chain reaction analysis revealed that the suppressive effect of KE-758 is based on the inhibition of messenger ribonucleic acid expression of TNF-alpha and IL-1 beta.	KE 758	97-103	interleukin 1 beta	Homo sapiens	189-198
11851725-0	2002	Oxysterols induce interleukin-1beta production in human macrophages.	Oxysterols	0-10	interleukin 1 beta	Homo sapiens	18-35
11851725-6	2002	RESULTS: A significant, dose-dependent increase in the secretion of IL-1beta was given by 25-hydroxycholesterol without the addition of lipopolysaccharide (LPS).	25-hydroxycholesterol	90-111	interleukin 1 beta	Homo sapiens	68-76
11851725-8	2002	A transient increase in IL-1beta mRNA expression was found in macrophages incubated with 25-hydroxycholesterol compared with untreated controls.	25-hydroxycholesterol	89-110	interleukin 1 beta	Homo sapiens	24-32
11851725-9	2002	In addition, 25-hydroxycholesterol dramatically increased the IL-1beta secretion induced by LPS.	25-hydroxycholesterol	13-34	interleukin 1 beta	Homo sapiens	62-70
11851725-10	2002	At a concentration of 5 microg mL(-1) of 25-hydroxycholesterol the LPS-induced IL-1beta secretion was increased by about 25-fold.	25-hydroxycholesterol	41-62	interleukin 1 beta	Homo sapiens	79-87
11835394-0	2002	Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response.	arsenite	0-8	interleukin 1 beta	Homo sapiens	70-79
11835394-4	2002	We examined the involvement of the heat shock response in arsenite-induced inhibition of NF-kappaB activity in IL-1beta-stimulated Caco-2 cells, a human colorectal adenocarcinoma cell line with enterocytic properties.	arsenite	58-66	interleukin 1 beta	Homo sapiens	111-119
12375150-4	2002	Pentoxifylline (PTX) is also known to inhibit such inflammatory mediators as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6.	Pentoxifylline	0-14	interleukin 1 beta	Homo sapiens	106-123
11835394-6	2002	Sodium arsenite blocked all of these responses to IL-1beta without inducing changes in heat shock factor activity or heat shock protein levels.	sodium arsenite	0-15	interleukin 1 beta	Homo sapiens	50-58
12210731-8	2002	Conditioned medium harvested from IL-1beta-treated XTC (containing high concentrations of OPG) inhibited RANKL-induced CD40 upregulation and cluster formation of DC.	N-Methyl-3,4-methylenedioxyamphetamine	51-54	interleukin 1 beta	Homo sapiens	34-42
11846849-13	2002	CONCLUSION: While PD and AL are each associated with increased GCF IL-1beta, patients with severe disease show higher IL-1beta GCF levels in shallow sites, suggesting that high GCF IL-1beta expression is in part a host trait, and not strictly a function of clinical parameters.	Aluminum	25-27	interleukin 1 beta	Homo sapiens	67-75
12537693-10	2002	In corroboration of previous findings with studies employing compound 516, purified LA(hepta) was found to induce the production of TNF-alpha, IL-1beta and IL-6 in hMNC, thus displaying moderate agonistic activity.	Heptachlor	87-92	interleukin 1 beta	Homo sapiens	143-151
12375150-4	2002	Pentoxifylline (PTX) is also known to inhibit such inflammatory mediators as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6.	Pentoxifylline	16-19	interleukin 1 beta	Homo sapiens	106-123
12204101-5	2002	CSC-induced IL-1beta expression was reduced by PD98059, a blocker of mitogen-actived protein kinase (MAPK) kinase (MEK), and by PDTC, a NFkappaB inhibitor.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	47-54	interleukin 1 beta	Homo sapiens	12-20
12424420-3	2002	STUDY DESIGN: The IL-1beta-induced IL-6/IL-8 release of HPMC from healthy donors and from patients with end-stage renal disease (ESRD) were measured before the start of chronic peritoneal dialysis (PD) and during PD therapy.	hydroxypropylmethylcellulose-lactose matrix	56-60	interleukin 1 beta	Homo sapiens	18-26
12424420-12	2002	However, HPMC from uremic patients produced more IL-8 on IL-1beta stimulation than the non-uremic controls (group 2, 53.5 +/- 15.7 pg/microg; group 3, 70.5 +/- 27.3 pg/microg vs. group 1, 24.0 +/- 11.8 pg/microg).	hydroxypropylmethylcellulose-lactose matrix	9-13	interleukin 1 beta	Homo sapiens	57-65
11980586-5	2002	PGE2 was the predominant COX product in IL-1beta-stimulated cells with no significant difference between HF-IPF and HF-NL (28.35 [9.09-89.09] vs. 17.12 [8.58-29.33] ng/10(6) cells/30 min, respectively; P = 0.25).	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	40-48
11581275-5	2001	We investigated the effect of IL-10 on IL-1 beta-induced inhibition of LTP and glutamate release.	Glutamic Acid	79-88	interleukin 1 beta	Homo sapiens	39-48
11739520-4	2001	IL-1beta and TNF-alpha, and to a lesser degree IL-6, accelerate facilitated glucose transport as measured by [(3)H]2-deoxyglucose uptake.	Glucose	76-83	interleukin 1 beta	Homo sapiens	0-8
11739520-4	2001	IL-1beta and TNF-alpha, and to a lesser degree IL-6, accelerate facilitated glucose transport as measured by [(3)H]2-deoxyglucose uptake.	Deoxyglucose	115-129	interleukin 1 beta	Homo sapiens	0-8
11739520-9	2001	IL-1beta regulation of glucose transport in chondrocytes depends on protein kinase C and p38 signal transduction pathways, and does not require phosphoinositide 3-kinase, extracellular signal-related kinase, or c-Jun N-terminal kinase activation.	Glucose	23-30	interleukin 1 beta	Homo sapiens	0-8
11739520-10	2001	IL-1beta-accelerated glucose transport in chondrocytes is not mediated by endogenous NO or eicosanoids.	Glucose	21-28	interleukin 1 beta	Homo sapiens	0-8
11739520-11	2001	These results demonstrate that stimulation of glucose transport represents a component of the chondrocyte response to IL-1beta.	Glucose	46-53	interleukin 1 beta	Homo sapiens	118-126
12545698-6	2002	Collagenase and elastase secretion by unstimulated and IL-1-stimulated HRPE cells was measured by 3H-labelled collagen and elastin cleavage.	Tritium	98-100	interleukin 1 beta	Homo sapiens	55-59
11898070-7	2002	RESULTS: Incubation of a human bone marrow cell culture with titanium-aluminium-vanadium particles led to a maximum release of interleukin-6, interleukin-1beta, and TNF-alpha at high particle concentration (10(9) particles per ml medium).	titanium-aluminium-vanadium	61-88	interleukin 1 beta	Homo sapiens	142-159
11673462-6	2001	Our result demonstrate that RYR1-mediated calcium signaling is involved in release of IL-1beta from B-lymphocytes and suggest that some of the symptoms seen during an MH episode may be due to IL-1beta production.	Calcium	42-49	interleukin 1 beta	Homo sapiens	86-94
11581275-7	2001	We observed that IL-10 abrogated the stimulatory effect of IL-1 beta on superoxide dismutase activity and reactive oxygen species production, whereas the H(2)O(2)-induced inhibition of LTP was also blocked by IL-10.	Reactive Oxygen Species	106-129	interleukin 1 beta	Homo sapiens	59-68
11726403-3	2001	Administration of IL-1beta/TNF-alpha increased ASM contractility to acetylcholine and impaired ASM relaxation to isoproterenol.	Acetylcholine	68-81	interleukin 1 beta	Homo sapiens	18-26
12005259-9	2001	Curcumin produced significant inhibition of IL-1beta and IL-8 but minimal inhibition of TNFalpha expression by preterm lung inflammatory cells at 20 uM concentrations.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	44-52
12005259-11	2001	Therefore, curcumin inhibits pro-inflammatory cytokine production (TNFalpha, IL-1beta and IL-8) by lung inflammatory cells ex vivo.	Curcumin	11-19	interleukin 1 beta	Homo sapiens	77-85
11709424-0	2001	Role of reactive oxygen species in IL-1 beta-stimulated sustained ERK activation and MMP-9 induction.	Reactive Oxygen Species	8-31	interleukin 1 beta	Homo sapiens	35-44
11709424-3	2001	IL-1 beta stimulated biphasic ERK activation in vascular smooth muscle (VSM) cells, a transient activation that reached a maximum at 15 min and declined to baseline levels within 1 h, and a second phase of sustained ERK activation lasting up to 8 h. To determine the role of ERK in IL-1 beta-stimulated MMP-9 induction, we treated cells with the specific ERK pathway inhibitor PD-98059 at different time intervals after IL-1 beta stimulation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	377-385	interleukin 1 beta	Homo sapiens	0-9
11709424-4	2001	Addition of PD-98059 up to 4 h after IL-1 beta stimulation significantly inhibited MMP-9 induction, suggesting a role for sustained ERK activation in MMP-9 induction.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	12-20	interleukin 1 beta	Homo sapiens	37-46
11709424-5	2001	IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene.	Superoxides	31-41	interleukin 1 beta	Homo sapiens	0-9
11709424-5	2001	IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene.	Superoxides	119-129	interleukin 1 beta	Homo sapiens	0-9
11709424-5	2001	IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene.	Acetylcysteine	140-159	interleukin 1 beta	Homo sapiens	0-9
11709424-5	2001	IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene.	Acetylcysteine	161-164	interleukin 1 beta	Homo sapiens	0-9
11709424-7	2001	In addition, both NAC treatment and MnSOD overexpression significantly inhibited IL-1 beta-stimulated MMP-9 induction (P &lt; 0.05).	Acetylcysteine	18-21	interleukin 1 beta	Homo sapiens	81-90
11709424-8	2001	The results demonstrate that IL-1 beta-dependent MMP-9 induction is mediated by superoxide-stimulated ERK activation.	Superoxides	80-90	interleukin 1 beta	Homo sapiens	29-38
11717138-5	2001	In contrast, inhibition of prostaglandin biosynthesis with a series of distinct inhibitors suggests that the ability of IL-1beta to upregulate ovarian PGS-2 transcripts is due, if only in part, to the generation of endogenous prostaglandin estradiol-17beta (E(2)).	Prostaglandins	27-40	interleukin 1 beta	Homo sapiens	120-128
11717138-5	2001	In contrast, inhibition of prostaglandin biosynthesis with a series of distinct inhibitors suggests that the ability of IL-1beta to upregulate ovarian PGS-2 transcripts is due, if only in part, to the generation of endogenous prostaglandin estradiol-17beta (E(2)).	prostaglandin estradiol-17beta	226-256	interleukin 1 beta	Homo sapiens	120-128
11717138-9	2001	Taken together, these findings suggest that the stimulatory effect of IL-1beta on PGS-2 expression is 1) independent of nitric oxide as well as ceramide, 2) dependent on prostaglandin E(2), 3) contingent on de novo protein biosynthesis, and 4) accounted for by both increased transcription and message stabilization.	Nitric Oxide	120-132	interleukin 1 beta	Homo sapiens	70-78
11717138-9	2001	Taken together, these findings suggest that the stimulatory effect of IL-1beta on PGS-2 expression is 1) independent of nitric oxide as well as ceramide, 2) dependent on prostaglandin E(2), 3) contingent on de novo protein biosynthesis, and 4) accounted for by both increased transcription and message stabilization.	Ceramides	144-152	interleukin 1 beta	Homo sapiens	70-78
11717138-9	2001	Taken together, these findings suggest that the stimulatory effect of IL-1beta on PGS-2 expression is 1) independent of nitric oxide as well as ceramide, 2) dependent on prostaglandin E(2), 3) contingent on de novo protein biosynthesis, and 4) accounted for by both increased transcription and message stabilization.	Prostaglandins E	170-185	interleukin 1 beta	Homo sapiens	70-78
11739521-5	2001	IFN-gamma-primed DLD-1 cells stimulated with 1 microg/ml of 6HIS flag induced high levels of NO (60 +/- 0.95 microM) comparable to the combination of IL-1beta and IFN-gamma (77 +/- 1.2) or purified native SD flag (66.3 +/- 0.98).	6his	60-64	interleukin 1 beta	Homo sapiens	150-158
11843762-5	2001	High challenge dose (20,000 EU/ml) induced whole blood interleukin-1beta and tumor necrosis factor alpha production in the blood compartment, which was higher with DIAPES than with polysulfone after 30 min.	diapes	164-170	interleukin 1 beta	Homo sapiens	55-104
11843762-5	2001	High challenge dose (20,000 EU/ml) induced whole blood interleukin-1beta and tumor necrosis factor alpha production in the blood compartment, which was higher with DIAPES than with polysulfone after 30 min.	polysulfone P 1700	181-192	interleukin 1 beta	Homo sapiens	55-104
11726403-3	2001	Administration of IL-1beta/TNF-alpha increased ASM contractility to acetylcholine and impaired ASM relaxation to isoproterenol.	Isoproterenol	113-126	interleukin 1 beta	Homo sapiens	18-26
11726403-5	2001	In the presence of DEX, the changes induced in ASM responsiveness were abrogated, and most of the IL-1beta/TNF-alpha-mediated changes in proinflammatory gene expression were repressed, although mRNA expression of a small number of genes was enhanced by DEX.	Dexamethasone	19-22	interleukin 1 beta	Homo sapiens	98-106
11724645-6	2001	In addition, IL-1beta was more potent than TNFalpha in inducing nitric oxide in both arthritides, and TNFalpha alone was almost ineffective in cells from rheumatoid arthritis patients.	Nitric Oxide	64-76	interleukin 1 beta	Homo sapiens	13-21
11726403-5	2001	In the presence of DEX, the changes induced in ASM responsiveness were abrogated, and most of the IL-1beta/TNF-alpha-mediated changes in proinflammatory gene expression were repressed, although mRNA expression of a small number of genes was enhanced by DEX.	Dexamethasone	253-256	interleukin 1 beta	Homo sapiens	98-106
11798464-7	2001	To date, we cannot provide a mechanism to explain the AT III-promoted modulation of TNF-alpha and IL-1beta generation in VSMC.	vsmc	121-125	interleukin 1 beta	Homo sapiens	98-106
11903492-9	2001	However, treatment of the cells with 2 mM butyrate significantly reduced the alpha1-PI level in IL-1beta-treated cells.	Butyrates	42-50	interleukin 1 beta	Homo sapiens	96-104
11903492-10	2001	In the cell culture medium, the presence of butyrate impaired the IL-1beta-induced alpha1-PI release to 17-35%.	Butyrates	44-52	interleukin 1 beta	Homo sapiens	66-74
11903492-12	2001	CONCLUSION: Our data show that butyrate inhibits alpha1-PI release from Caco-2 colonocytes treated with IL-1beta.	Butyrates	31-39	interleukin 1 beta	Homo sapiens	104-112
11717194-4	2001	In terms of ECM expression, adenosine and the adenosine receptor agonists, 2-CADO and CPA, enhanced constitutive and IL-1beta-induced expression of hyaluronate synthase mRNA, but not the mRNA levels of other ECM, such as collagen type I, III and fibronectin.	2-Chloroadenosine	75-81	interleukin 1 beta	Homo sapiens	117-125
11717194-5	2001	Moreover, the adherence of IL-1beta-stimulated HGF to activated lymphocytes was also inhibited by adenosine, which is in part explained by the fact that adenosine down-regulated the IL-1beta-induced expression of ICAM-1 on HGF.	Adenosine	98-107	interleukin 1 beta	Homo sapiens	27-35
11717194-5	2001	Moreover, the adherence of IL-1beta-stimulated HGF to activated lymphocytes was also inhibited by adenosine, which is in part explained by the fact that adenosine down-regulated the IL-1beta-induced expression of ICAM-1 on HGF.	Adenosine	98-107	interleukin 1 beta	Homo sapiens	182-190
11717194-5	2001	Moreover, the adherence of IL-1beta-stimulated HGF to activated lymphocytes was also inhibited by adenosine, which is in part explained by the fact that adenosine down-regulated the IL-1beta-induced expression of ICAM-1 on HGF.	Adenosine	153-162	interleukin 1 beta	Homo sapiens	27-35
11717194-5	2001	Moreover, the adherence of IL-1beta-stimulated HGF to activated lymphocytes was also inhibited by adenosine, which is in part explained by the fact that adenosine down-regulated the IL-1beta-induced expression of ICAM-1 on HGF.	Adenosine	153-162	interleukin 1 beta	Homo sapiens	182-190
11859933-0	2001	Gangliosides inhibit the release of interleukin-1beta in amyloid beta-protein-treated human monocytic cells.	Gangliosides	0-12	interleukin 1 beta	Homo sapiens	36-53
11717194-0	2001	Adenosine regulates the IL-1 beta-induced cellular functions of human gingival fibroblasts.	Adenosine	0-9	interleukin 1 beta	Homo sapiens	24-33
11717194-3	2001	Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine (2-CADO), N(6)-cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta-induced IL-6 and IL-8 production.	Adenosine	12-21	interleukin 1 beta	Homo sapiens	168-176
11717194-3	2001	Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine (2-CADO), N(6)-cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta-induced IL-6 and IL-8 production.	2-Chloroadenosine	89-95	interleukin 1 beta	Homo sapiens	168-176
11717194-3	2001	Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine (2-CADO), N(6)-cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta-induced IL-6 and IL-8 production.	N(6)-cyclopentyladenosine	98-123	interleukin 1 beta	Homo sapiens	168-176
11717194-3	2001	Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine (2-CADO), N(6)-cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta-induced IL-6 and IL-8 production.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	133-141	interleukin 1 beta	Homo sapiens	168-176
11717194-4	2001	In terms of ECM expression, adenosine and the adenosine receptor agonists, 2-CADO and CPA, enhanced constitutive and IL-1beta-induced expression of hyaluronate synthase mRNA, but not the mRNA levels of other ECM, such as collagen type I, III and fibronectin.	Adenosine	28-37	interleukin 1 beta	Homo sapiens	117-125
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p &lt; 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	163-175	interleukin 1 beta	Homo sapiens	15-23
11700032-4	2001	In human primary cultured decidual cells, a p38 inhibitor, SB202190, significantly inhibited both prostaglandin F(2alpha) production and COX-2 expression induced by stimulation with IL-1beta.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	59-67	interleukin 1 beta	Homo sapiens	182-190
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p &lt; 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	163-175	interleukin 1 beta	Homo sapiens	242-250
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p &lt; 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	193-205	interleukin 1 beta	Homo sapiens	15-23
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p &lt; 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	193-205	interleukin 1 beta	Homo sapiens	242-250
11848192-0	2001	The effects of folic acid application on IL-1beta levels of human gingival fibroblasts stimulated by phenytoin and TNFalpha in vitro: a preliminary study.	Folic Acid	15-25	interleukin 1 beta	Homo sapiens	41-49
11848192-0	2001	The effects of folic acid application on IL-1beta levels of human gingival fibroblasts stimulated by phenytoin and TNFalpha in vitro: a preliminary study.	Phenytoin	101-110	interleukin 1 beta	Homo sapiens	41-49
11848192-3	2001	The purpose of this study was to assess the role of FA supplementation on PHT-induced overgrowth by investigating its effect on IL-1beta production of human gingival fibroblasts induced by tumor necrosis factor alfa (TNFalpha) in cell culture.	Phenytoin	74-77	interleukin 1 beta	Homo sapiens	128-136
11848192-7	2001	The cellular IL-1beta level in the PHT group was 1 pg/ml.	Phenytoin	35-38	interleukin 1 beta	Homo sapiens	13-21
11848192-10	2001	When PHT and either 20 or 40 ng/ml FA were simultaneously added into TNFalpha-induced cultures, the IL-1beta levels were 1.8 and 1.3 pg/ml, respectively.	Phenytoin	5-8	interleukin 1 beta	Homo sapiens	100-108
11742038-1	2001	The proinflammatory cytokines, interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma), are cytotoxic to pancreatic islet beta cells, possibly by inducing nitric oxide and/or oxygen radical production in the beta cells.	Nitric Oxide	201-213	interleukin 1 beta	Homo sapiens	31-48
11742038-1	2001	The proinflammatory cytokines, interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma), are cytotoxic to pancreatic islet beta cells, possibly by inducing nitric oxide and/or oxygen radical production in the beta cells.	Reactive Oxygen Species	221-235	interleukin 1 beta	Homo sapiens	31-48
11700032-4	2001	In human primary cultured decidual cells, a p38 inhibitor, SB202190, significantly inhibited both prostaglandin F(2alpha) production and COX-2 expression induced by stimulation with IL-1beta.	Prostaglandins F	98-113	interleukin 1 beta	Homo sapiens	182-190
11710710-2	2001	OBJECTIVE: To evaluate the ability of diacerein, an interleukin-1beta inhibitor, to slow the progressive decrease in joint space width observed in patients with hip osteoarthritis (OA).	diacerein	38-47	interleukin 1 beta	Homo sapiens	52-69
11698472-5	2001	IL-1beta primed neutrophils for enhanced release of superoxide (O(2)(-)) stimulated by FMLP in parallel with increased phosphorylation of p38 MAPK.	Superoxides	52-62	interleukin 1 beta	Homo sapiens	0-8
11698472-5	2001	IL-1beta primed neutrophils for enhanced release of superoxide (O(2)(-)) stimulated by FMLP in parallel with increased phosphorylation of p38 MAPK.	Superoxides	64-68	interleukin 1 beta	Homo sapiens	0-8
11698472-6	2001	IL-1beta also induced O(2)(-) release and up-regulation of CD11b and CD15, and both responses were inhibited by SB203580 (p38 MAPK inhibitor), suggesting that p38 MAPK activation mediates IL-1beta-induced O(2)(-) release and up-regulation of CD11b and CD15.	SB 203580	112-120	interleukin 1 beta	Homo sapiens	0-8
11698472-6	2001	IL-1beta also induced O(2)(-) release and up-regulation of CD11b and CD15, and both responses were inhibited by SB203580 (p38 MAPK inhibitor), suggesting that p38 MAPK activation mediates IL-1beta-induced O(2)(-) release and up-regulation of CD11b and CD15.	SB 203580	112-120	interleukin 1 beta	Homo sapiens	188-196
11672919-5	2001	It was shown that only Ticovac, which contains no albumin as a stabilizer, can induce relative high amounts of TNF-alpha (P &lt; or = 0.0001) and lower amounts of IL-1 beta (P &lt; or = 0.05).	ticovac	23-30	interleukin 1 beta	Homo sapiens	163-172
11687457-6	2001	Our clinical studies have shown that methylprednisolone is capable of reducing the levels of TNF-alpha, IL-1 beta, and IL-6 in ARDS patients.	Methylprednisolone	37-55	interleukin 1 beta	Homo sapiens	104-113
11668357-8	2001	Levels of spontaneously released IL-1beta were below 10 pg/ml in the CM of LCP, while NC had a mean value of 1,217 +/- 74 pg/ml.	Perchloric Acid	75-78	interleukin 1 beta	Homo sapiens	33-41
11687440-9	2001	Differences between pre-antibiotic and follow-up cytokine/creatinine ratios were significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	58-68	interleukin 1 beta	Homo sapiens	97-106
11687440-10	2001	Differences between pre-antibiotic and control cytokine/creatinine ratios were also significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	56-66	interleukin 1 beta	Homo sapiens	100-109
11704656-6	2001	ELISA experiments have established that gp120 enhances immunoreactive IL-1beta levels in the culture medium and this is prevented by exposure to the IL-1 converting enzyme (ICE) inhibitor t-butoxycarbonyl-L-aspartic acid benzyl ester-chloromethylketone [Boc-Asp(OBzl)-CMK] used at a concentration (2.5 microM) which significantly (P&lt;0.001) reduces cell death.	-l-aspartic acid benzyl ester	204-233	interleukin 1 beta	Homo sapiens	70-78
11704656-6	2001	ELISA experiments have established that gp120 enhances immunoreactive IL-1beta levels in the culture medium and this is prevented by exposure to the IL-1 converting enzyme (ICE) inhibitor t-butoxycarbonyl-L-aspartic acid benzyl ester-chloromethylketone [Boc-Asp(OBzl)-CMK] used at a concentration (2.5 microM) which significantly (P&lt;0.001) reduces cell death.	chloromethylketone	234-252	interleukin 1 beta	Homo sapiens	70-78
11704656-6	2001	ELISA experiments have established that gp120 enhances immunoreactive IL-1beta levels in the culture medium and this is prevented by exposure to the IL-1 converting enzyme (ICE) inhibitor t-butoxycarbonyl-L-aspartic acid benzyl ester-chloromethylketone [Boc-Asp(OBzl)-CMK] used at a concentration (2.5 microM) which significantly (P&lt;0.001) reduces cell death.	boc-asp	254-261	interleukin 1 beta	Homo sapiens	70-78
11704656-8	2001	Death of CHP100 cells induced by gp120 is also prevented by acetyl-Tyr-Val-Ala-Asp-chloromethylketone (Ac-YVAD-CMK; 10-100 microM), a second inhibitor of ICE, supporting the concept that the viral protein stimulates the conversion of the 31 kDa pro-IL-1beta in to the 17 kDa mature cytokine which is then secreted to cause death.	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone	60-101	interleukin 1 beta	Homo sapiens	249-257
11704656-8	2001	Death of CHP100 cells induced by gp120 is also prevented by acetyl-Tyr-Val-Ala-Asp-chloromethylketone (Ac-YVAD-CMK; 10-100 microM), a second inhibitor of ICE, supporting the concept that the viral protein stimulates the conversion of the 31 kDa pro-IL-1beta in to the 17 kDa mature cytokine which is then secreted to cause death.	ac-yvad	103-110	interleukin 1 beta	Homo sapiens	249-257
11687457-13	2001	We have also shown that steady-state mRNA levels of TNF-alpha, IL-1 beta, and IL-6 in LPS-activated cells were reduced by treatment of such cells with methylprednisolone, in a concentration-dependent manner.	Methylprednisolone	151-169	interleukin 1 beta	Homo sapiens	63-72
11687457-4	2001	In addition, we have shown that the intracellular milieu of phagocytic cells that are exposed to supraoptimal concentrations of TNF-alpha, IL-1 beta, and IL-6 or lipopolysaccharide (LPS) favors survival and replication of ingested bacteria.	supraoptimal	97-109	interleukin 1 beta	Homo sapiens	139-148
11605009-7	2001	Pretreatment with SB203085 inhibited IL-1beta-induced p38 and AKT phosphorylation.	sb203085	18-26	interleukin 1 beta	Homo sapiens	37-45
11701714-9	2001	On the other hand, 8-d treatment with leuprorelin acetate (100 nmol/liter) reduced dexamethasone + IL-1beta-induced activity and a mRNA level of aromatase by 28% and 42%, respectively.	8-d	19-22	interleukin 1 beta	Homo sapiens	99-107
11691650-9	2001	Taurine was protective against SNP and IL-1 beta in both the groups, methionine provided a less protective effect than taurine, and pretreatment with beta-alanine had no protective effect.	Taurine	0-7	interleukin 1 beta	Homo sapiens	39-48
11691650-10	2001	Taurine supplementation of the maternal diet reduced the rate of apoptosis induced by IL-1 beta in control islets and suppressed that induced by IL-1 beta in LP islets.	Taurine	0-7	interleukin 1 beta	Homo sapiens	86-95
11691650-10	2001	Taurine supplementation of the maternal diet reduced the rate of apoptosis induced by IL-1 beta in control islets and suppressed that induced by IL-1 beta in LP islets.	Taurine	0-7	interleukin 1 beta	Homo sapiens	145-154
11774033-3	2001	Inhibition of protein synthesis with cycloheximide blocked IL-1beta-mediated induction of matrilysin mRNA suggesting that synthesis of one or more additional factors is required for IL-1beta-induced promatrilysin protein expression.	Cycloheximide	37-50	interleukin 1 beta	Homo sapiens	59-67
11760899-6	2001	RESULTS: Dexamethasone induced receptor-mediated reporter gene transcription and receptor translocation, while interleukin-1beta significantly inhibited dexamethasone effects.	Dexamethasone	153-166	interleukin 1 beta	Homo sapiens	111-128
11760899-10	2001	Our data are consistent with the notion that interleukin-1beta produced during inflammatory response induces steroid resistance, which is a common clinical problem in treating patients with inflammatory bowel disease.	Steroids	109-116	interleukin 1 beta	Homo sapiens	45-62
11712859-4	2001	In RA and OA synoviocytes, the induction of inflammatory cytokine mRNA expression such as TNF-alpha and IL-1beta was significantly inhibited by the natural PPAR-gamma agonist, 15 deoxy-Delta(12,14)prostaglandin J(2)(15d-PGJ(2)).	prostaglandin j	197-212	interleukin 1 beta	Homo sapiens	104-112
11673554-4	2001	Treatment of cells with NaClO(3), an inhibitor of sulfation, prevented HA binding in a significant percentage of CD14(+) PBMC induced by TNF-alpha, LPS, IL-1beta, or IFN-gamma.	Sodium Hypochlorite	24-29	interleukin 1 beta	Homo sapiens	153-161
11788788-0	2001	Nitric oxide inhibits endothelial IL-1[beta]-induced ICAM-1 gene expression at the transcriptional level decreasing Sp1 and AP-1 activity.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	34-43
11788788-8	2001	Using gel-shift assays and double-stranded oligonucleotide consensus sequences of the known transcription factor binding sites of the ICAM-1 promoter, Sp1 and AP-1 were identified as transcriptional activators of IL-1beta-driven ICAM-1 expression.	double-stranded oligonucleotide	27-58	interleukin 1 beta	Homo sapiens	213-221
11698053-4	2001	Interleukin (IL)-1 beta caused a significant increase in NF-kappa B-mediated granulocyte/macrophage colony stimulating factor (GM-CSF) release, which was inhibited by the glucocorticoid mometasone furoate (MF) (EC(50)=2 x 10(-11) M).	Mometasone Furoate	186-204	interleukin 1 beta	Homo sapiens	0-23
11583705-7	2001	PMPs induced interleukin-8 (IL-8), interleukin-1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF alpha) production by THP-1.	pmps	0-4	interleukin 1 beta	Homo sapiens	35-53
11583705-7	2001	PMPs induced interleukin-8 (IL-8), interleukin-1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF alpha) production by THP-1.	pmps	0-4	interleukin 1 beta	Homo sapiens	55-64
11583705-8	2001	PMPs also induced IL-8, IL-1 beta, and interleukin-6 (IL-6) production by ECs.	pmps	0-4	interleukin 1 beta	Homo sapiens	24-33
11583711-3	2001	Oxidized LDL, as well as a combination of cholesterol and 25-hydroxycholesterol, induced tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta (IL-1 beta) mRNA as measured by quantitative real time PCR, by a maximum of two- to fourfold following a 24-h incubation.	Cholesterol	42-53	interleukin 1 beta	Homo sapiens	132-150
11583711-3	2001	Oxidized LDL, as well as a combination of cholesterol and 25-hydroxycholesterol, induced tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta (IL-1 beta) mRNA as measured by quantitative real time PCR, by a maximum of two- to fourfold following a 24-h incubation.	Cholesterol	42-53	interleukin 1 beta	Homo sapiens	152-161
11583711-3	2001	Oxidized LDL, as well as a combination of cholesterol and 25-hydroxycholesterol, induced tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta (IL-1 beta) mRNA as measured by quantitative real time PCR, by a maximum of two- to fourfold following a 24-h incubation.	Hydroxycholesterols	61-79	interleukin 1 beta	Homo sapiens	132-150
11583711-3	2001	Oxidized LDL, as well as a combination of cholesterol and 25-hydroxycholesterol, induced tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta (IL-1 beta) mRNA as measured by quantitative real time PCR, by a maximum of two- to fourfold following a 24-h incubation.	Hydroxycholesterols	61-79	interleukin 1 beta	Homo sapiens	152-161
11583711-6	2001	VK-19911 (Pyridine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-dihydrochloride), a specific inhibitor of p38 alpha, prevented the induction of TNFalpha and IL-1 beta by oxidized LDL in a dose-dependent manner.	4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1h-imidazol-5-yl]-dihydrochloride	20-93	interleukin 1 beta	Homo sapiens	171-180
11568002-3	2001	Results show that a fraction of the intracellular IL-1beta precursor colocalizes with the hydrolase cathepsin D in endolysosomes of dendritic cells; secretion of both proteins is elicited by stimuli that induce intracellular calcium increases.	Calcium	225-232	interleukin 1 beta	Homo sapiens	50-58
11676825-7	2001	We used the ATP-binding cassette 1 transporter inhibitor glybenclamide, which has been previously shown to block interleukin-1beta secretion in human monocytes.	Glyburide	57-70	interleukin 1 beta	Homo sapiens	113-130
11585641-4	2001	Both IL-1beta- mRNAs and proteins hypoxia-induced NF-kappaB activation were blocked by the proteasome inhibitor, MG-132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	113-119	interleukin 1 beta	Homo sapiens	5-13
11585641-5	2001	MG-132 inhibited IL-1beta-induced up-regulation of IL-1beta and IL-8 mRNA and protein but increased hypoxia-stimulated expression/release of IL-1beta and IL-8.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-6	interleukin 1 beta	Homo sapiens	17-25
11585641-5	2001	MG-132 inhibited IL-1beta-induced up-regulation of IL-1beta and IL-8 mRNA and protein but increased hypoxia-stimulated expression/release of IL-1beta and IL-8.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-6	interleukin 1 beta	Homo sapiens	51-59
11585641-5	2001	MG-132 inhibited IL-1beta-induced up-regulation of IL-1beta and IL-8 mRNA and protein but increased hypoxia-stimulated expression/release of IL-1beta and IL-8.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-6	interleukin 1 beta	Homo sapiens	51-59
11561079-4	2001	In this study, two novel pharmacological agents, CP-424,174 and CP-412,245, are identified as potent inhibitors of stimulus-coupled IL-1beta post-translational processing.	cp-412	64-70	interleukin 1 beta	Homo sapiens	132-140
11561079-5	2001	These agents, both diarylsulfonylureas, block formation of mature IL-1beta without increasing the amount of procytokine that is released extracellularly, and they inhibit independently of the secretion stimulus used.	diarylsulfonylureas	19-38	interleukin 1 beta	Homo sapiens	66-74
11561079-7	2001	As a result of this decrease, monocyte conditioned medium prepared in the presence of CP-424,174 demonstrated a greatly diminished capacity to promote an IL-1-dependent response (induction of serum amyloid A synthesis by Hep3B cells).	cp-424	86-92	interleukin 1 beta	Homo sapiens	154-158
11585122-4	2001	Furthermore, fluprostenol, a specific FP receptor agonist, increased MMP-1 production and induced a synergistic enhancement of IL-1beta-induced MMP-1 production in HGF, similar to PGF2alpha.	fluprostenol	13-25	interleukin 1 beta	Homo sapiens	127-135
11585122-6	2001	Northern blot analysis revealed that PGF2alpha enhanced MMP-1 mRNA expression in HGF and that PGF2alpha increased MMP-1 mRNA levels induced by IL-1beta.	Dinoprost	94-103	interleukin 1 beta	Homo sapiens	143-151
11585122-7	2001	In conclusion, we suggest that PGF2alpha increases MMP-1 production in HGF and synergistically enhances MMP-1 production in IL-1beta-stimulated HGF.	Dinoprost	31-40	interleukin 1 beta	Homo sapiens	124-132
11591574-7	2001	The TZD inhibited the increase of MCP-1 secretion by IL-1beta and TNF-alpha treatment.	2,4-thiazolidinedione	4-7	interleukin 1 beta	Homo sapiens	53-61
11591574-8	2001	The TZD inhibited the expression of MCP-1 messenger RNA with IL-1beta treatment, but not with TNF-alpha treatment.	2,4-thiazolidinedione	4-7	interleukin 1 beta	Homo sapiens	61-69
11678909-9	2001	KE-298 blocked this IL-1beta-induced pro-MMP-2 activation and MT1-MMP expression, but did not affect IL-1beta-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells.	esonarimod	0-6	interleukin 1 beta	Homo sapiens	20-28
11825017-10	2001	Doxycycline (10 microg ml(-1)) suppressed MMP-9 protein level and activity, but not its mRNA, that was stimulated by IL-1beta and TNF-alpha (1 ng ml(-1)).	Doxycycline	0-11	interleukin 1 beta	Homo sapiens	117-125
11686835-8	2001	RESULTS: Interleukin-1beta treatment dose- and time-dependently increased COX-2 mRNA and protein expression levels, and enhanced PGE2 production/secretion in AGS cells.	Dinoprostone	129-133	interleukin 1 beta	Homo sapiens	9-26
11686835-11	2001	To demonstrate the cause-effect relationship, we showed that inhibition of MEK and p38 MAP kinase with specific inhibitors suppressed IL-1beta-mediated increases in COX-2 mRNA and protein levels, and the PGE2 production.	Dinoprostone	204-208	interleukin 1 beta	Homo sapiens	134-142
11551520-5	2001	In the present study, we demonstrated that cepharanthine suppresses the production of inflammatory cytokines and a chemokine, i.e. TNF-alpha, interleukin (IL)-1beta, IL-6, and IL-8, in human monocytic cell cultures, including primary monocyte/macrophage cultures.	cepharanthine	43-56	interleukin 1 beta	Homo sapiens	142-164
29537532-10	2001	CONCLUSION: IL-1alpha and IL-1beta appear to have critical and nonredundant roles in the generation and regulation of potent IgG2 responses, which appear to be important in human responses to carbohydrate-bearing bacteria.	Carbohydrates	192-204	interleukin 1 beta	Homo sapiens	26-34
11445585-0	2001	Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating NF-kappa B activation in response to tumor necrosis factor-alpha and interleukin-1beta.	Leukotrienes	48-59	interleukin 1 beta	Homo sapiens	189-206
11445585-5	2001	Transfection of a kinase-inactive mutant of lambda/iotaPKC in NIH-3T3 fibroblasts completely abolished TNF-alpha/IL-1beta-stimulated cellular arachidonic acid release and cPLA(2) activation assayed in vitro, confirming the role of lambda/iotaPKC in cPLA(2) regulation.	Arachidonic Acid	142-158	interleukin 1 beta	Homo sapiens	113-121
11699474-10	2001	CONCLUSION: IL-1 alpha and IL-1 beta appear to have critical and non-redundant roles in the generation and regulation of potent IgG2 responses, which appear to be important in human responses to carbohydrate-bearing bacteria.	Carbohydrates	195-207	interleukin 1 beta	Homo sapiens	27-36
11762793-0	2001	Interleukin-1beta gene and receptor antagonist gene polymorphisms in patients with calcium oxalate stones.	Calcium Oxalate	83-98	interleukin 1 beta	Homo sapiens	0-17
11527419-4	2001	Moreover, treatment of cells with R(+)-methanandamide in the presence of interleukin-1beta led to an overadditive induction of COX-2 expression.	methanandamide	34-53	interleukin 1 beta	Homo sapiens	73-90
11527733-0	2001	Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1beta) production.	pyridazine	37-47	interleukin 1 beta	Homo sapiens	75-93
11594793-7	2001	When the levels of pro-inflammatory cytokines were measured, a significant time-dependent increase in TNF-alpha, IL-6 and IL-1beta production was observed in FS-derived cultures, but not in VP-derived cultures.	phenylalanylserine	158-160	interleukin 1 beta	Homo sapiens	122-130
11527733-0	2001	Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1beta) production.	pyridazine	37-47	interleukin 1 beta	Homo sapiens	95-103
11527733-1	2001	New pyridazine derivatives were prepared, and their abilities to inhibit IL-1beta production were evaluated.	pyridazine	4-14	interleukin 1 beta	Homo sapiens	73-81
11527734-0	2001	Synthesis and bioactivities of novel 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives: inhibitors of interleukin-1 beta (IL-1beta) production.	5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one	37-80	interleukin 1 beta	Homo sapiens	108-126
11527734-0	2001	Synthesis and bioactivities of novel 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives: inhibitors of interleukin-1 beta (IL-1beta) production.	5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one	37-80	interleukin 1 beta	Homo sapiens	128-136
11527734-1	2001	New 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives were prepared, and their abilities to inhibit IL-1beta production were evaluated.	5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one	4-47	interleukin 1 beta	Homo sapiens	106-114
11519039-1	2001	Current evidence has suggested the possible involvement of ROS as signaling messengers in IL-1beta- or LPS-induced gene expression.	ros	59-62	interleukin 1 beta	Homo sapiens	90-98
11500179-2	2001	This study extends these findings by investigating the effect of three aldehydes (2,4-decadienal (2,4-DDE), hexanal and 4-hydroxynonenal (4-HNE)) on TNF-alpha and IL-1beta mRNA expression.	Aldehydes	71-80	interleukin 1 beta	Homo sapiens	163-171
11592370-9	2001	IL-1beta significantly increased PGE2 production.	Dinoprostone	33-37	interleukin 1 beta	Homo sapiens	0-8
11592370-10	2001	The combination of IL-1beta and TNFalpha had an additive effect on PGE2 production, while addition of IL-17 to TNFalpha or IL-1beta synergistically enhanced PGE2 production.	Dinoprostone	67-71	interleukin 1 beta	Homo sapiens	19-27
11592370-10	2001	The combination of IL-1beta and TNFalpha had an additive effect on PGE2 production, while addition of IL-17 to TNFalpha or IL-1beta synergistically enhanced PGE2 production.	Dinoprostone	157-161	interleukin 1 beta	Homo sapiens	123-131
11592370-11	2001	Inhibition of NO production by 1400W significantly increased IL-1beta-stimulated PGE2 production, and inhibition of PGE2 production by the COX-2 inhibitor N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide significantly increased IL-17-stimulated NO production.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	31-36	interleukin 1 beta	Homo sapiens	61-69
11592370-11	2001	Inhibition of NO production by 1400W significantly increased IL-1beta-stimulated PGE2 production, and inhibition of PGE2 production by the COX-2 inhibitor N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide significantly increased IL-17-stimulated NO production.	Dinoprostone	81-85	interleukin 1 beta	Homo sapiens	61-69
11502570-1	2001	Interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS), resulting in the release of nitric oxide (NO) from glomerular mesangial cells.	Nitric Oxide	51-63	interleukin 1 beta	Homo sapiens	0-17
11502570-1	2001	Interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS), resulting in the release of nitric oxide (NO) from glomerular mesangial cells.	Nitric Oxide	51-63	interleukin 1 beta	Homo sapiens	19-27
11500179-2	2001	This study extends these findings by investigating the effect of three aldehydes (2,4-decadienal (2,4-DDE), hexanal and 4-hydroxynonenal (4-HNE)) on TNF-alpha and IL-1beta mRNA expression.	2,4-decadienal	82-96	interleukin 1 beta	Homo sapiens	163-171
11500179-2	2001	This study extends these findings by investigating the effect of three aldehydes (2,4-decadienal (2,4-DDE), hexanal and 4-hydroxynonenal (4-HNE)) on TNF-alpha and IL-1beta mRNA expression.	2,4-decadienal	98-105	interleukin 1 beta	Homo sapiens	163-171
11500179-2	2001	This study extends these findings by investigating the effect of three aldehydes (2,4-decadienal (2,4-DDE), hexanal and 4-hydroxynonenal (4-HNE)) on TNF-alpha and IL-1beta mRNA expression.	4-hydroxy-2-nonenal	120-136	interleukin 1 beta	Homo sapiens	163-171
11500179-2	2001	This study extends these findings by investigating the effect of three aldehydes (2,4-decadienal (2,4-DDE), hexanal and 4-hydroxynonenal (4-HNE)) on TNF-alpha and IL-1beta mRNA expression.	4-hydroxy-2-nonenal	138-143	interleukin 1 beta	Homo sapiens	163-171
11575451-5	2001	In cells pretreated with butyrate, a time- and dose-dependent inhibition of IL-1beta-mediated NF-kappaB nuclear translocation was observed.	Butyrates	25-33	interleukin 1 beta	Homo sapiens	76-84
11575451-7	2001	These data indicate that inhibition of IL-1beta-induced NF-kappaB activation by butyrate does not require an intact IkappaB alpha protein.	Butyrates	80-88	interleukin 1 beta	Homo sapiens	39-47
11509539-6	2001	Pretreatment of VSM cells with the NO donor DETA NONOate significantly (P &lt; 0.05) decreased IL-1 beta-stimulated superoxide generation.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	44-56	interleukin 1 beta	Homo sapiens	95-104
11509539-5	2001	Stimulation of VSM cells with IL-1 beta significantly (P &lt; 0.05) increased superoxide production, ERK activation, and MMP-9 induction.	Superoxides	78-88	interleukin 1 beta	Homo sapiens	30-39
11527948-12	2001	Pretreatment of RPE cells with a NF-kappa B inhibitor, PDTC, resulted in dose-dependent decrease in IL-1 beta-induced COX-2 gene expression and PG production.	Prostaglandins	144-146	interleukin 1 beta	Homo sapiens	100-109
11509539-6	2001	Pretreatment of VSM cells with the NO donor DETA NONOate significantly (P &lt; 0.05) decreased IL-1 beta-stimulated superoxide generation.	Superoxides	116-126	interleukin 1 beta	Homo sapiens	95-104
11509539-7	2001	In addition, pretreatment of VSM cells with a specific ERK pathway inhibitor, PD-98059, or DETA NONOate inhibited IL-1 beta-stimulated ERK activation and MMP-9 induction.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	78-86	interleukin 1 beta	Homo sapiens	114-123
11509550-3	2001	TNF-alpha alone, at concentrations up to 10 ng/ml, had no effect on COX-2 protein expression; at concentrations as low as 0.1 ng/ml, it significantly enhanced the ability of IL-1 beta (0.2 ng/ml) to induce COX-2 and to increase PGE(2) release.	Prostaglandins E	228-231	interleukin 1 beta	Homo sapiens	174-183
11509539-7	2001	In addition, pretreatment of VSM cells with a specific ERK pathway inhibitor, PD-98059, or DETA NONOate inhibited IL-1 beta-stimulated ERK activation and MMP-9 induction.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	91-103	interleukin 1 beta	Homo sapiens	114-123
11509550-6	2001	Combined administration of IL-1 beta (0.2 ng/ml) and TNF-alpha (0.1 or 1.0 ng/ml) reduced the ability of isoproterenol to decrease human airway smooth muscle cell stiffness, as measured by magnetic twisting cytometry, even though individually these cytokines, at these concentrations, had no effect on isoproterenol responses.	Isoproterenol	105-118	interleukin 1 beta	Homo sapiens	27-36
11509550-6	2001	Combined administration of IL-1 beta (0.2 ng/ml) and TNF-alpha (0.1 or 1.0 ng/ml) reduced the ability of isoproterenol to decrease human airway smooth muscle cell stiffness, as measured by magnetic twisting cytometry, even though individually these cytokines, at these concentrations, had no effect on isoproterenol responses.	Isoproterenol	302-315	interleukin 1 beta	Homo sapiens	27-36
11509550-7	2001	Treatment with the selective COX-2 inhibitor NS-398 abolished the synergistic effects of TNF-alpha and IL-1 beta on beta-adrenergic responsiveness.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	45-51	interleukin 1 beta	Homo sapiens	103-112
11509550-8	2001	Our results indicate that low concentrations of IL-1 beta and TNF-alpha synergize to promote beta-adrenergic hyporesponsiveness and that effects on COX-2 expression and PGE(2) are responsible for these events.	Prostaglandins E	169-172	interleukin 1 beta	Homo sapiens	48-57
11509539-9	2001	We conclude that NO inhibits IL-1 beta-stimulated MMP-9 induction by inhibiting superoxide generation and subsequent ERK activation.	Superoxides	80-90	interleukin 1 beta	Homo sapiens	29-38
11732737-1	2001	Interleukin-1 beta (IL-1beta) is a potent bone-resorptive cytokine that also mediates soft-tissue destruction by stimulating prostaglandin production and inducing collagenase and other protease activity.	Prostaglandins	125-138	interleukin 1 beta	Homo sapiens	0-18
11732737-1	2001	Interleukin-1 beta (IL-1beta) is a potent bone-resorptive cytokine that also mediates soft-tissue destruction by stimulating prostaglandin production and inducing collagenase and other protease activity.	Prostaglandins	125-138	interleukin 1 beta	Homo sapiens	20-28
11520053-0	2001	LL-Z1271alpha: an interleukin-1beta production inhibitor.	LL-Z 1271alpha	0-13	interleukin 1 beta	Homo sapiens	18-35
11769462-3	2001	Reports have shown that ATP stimulates microglia to release various biologically active substances, such as interleukin-1 beta, tumor necrosis factor-alpha, and plasminogen.	Adenosine Triphosphate	24-27	interleukin 1 beta	Homo sapiens	108-155
11423555-0	2001	Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts.	Dinoprostone	0-18	interleukin 1 beta	Homo sapiens	140-158
11423555-2	2001	We explored a positive feedback, prostaglandin E(2) (PGE(2))-dependent stabilization of COX-2 mRNA mediated by the p38 MAPK cascade in IL-1 beta-stimulated human synovial fibroblasts.	Dinoprostone	33-51	interleukin 1 beta	Homo sapiens	135-144
11423555-2	2001	We explored a positive feedback, prostaglandin E(2) (PGE(2))-dependent stabilization of COX-2 mRNA mediated by the p38 MAPK cascade in IL-1 beta-stimulated human synovial fibroblasts.	Dinoprostone	53-59	interleukin 1 beta	Homo sapiens	135-144
11520738-5	2001	SB 203580 selectively inhibited IL-1beta-stimulated activation of p38 MAP kinase; U 0126 was selective against p42/p44 ERK activity.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	32-40
11525777-11	2001	Plasma obtained from the blood was tested for its ability to inhibit prostanoid formation in interleukin-1beta-treated A549 cells (cyclooxygenase-2 system) and human washed platelets (cyclooxygenase-1 system).	Prostaglandins	69-79	interleukin 1 beta	Homo sapiens	93-110
11520053-1	2001	LL-Z1271alpha, a fungal metabolite, dose-dependently inhibited interleukin-1beta (IL-1beta) production in lipopolysaccharide (LPS)-stimulated human whole blood.	LL-Z 1271alpha	0-13	interleukin 1 beta	Homo sapiens	63-80
11520053-1	2001	LL-Z1271alpha, a fungal metabolite, dose-dependently inhibited interleukin-1beta (IL-1beta) production in lipopolysaccharide (LPS)-stimulated human whole blood.	LL-Z 1271alpha	0-13	interleukin 1 beta	Homo sapiens	82-90
11520053-3	2001	Data presented suggest that LL-Z1271alpha inhibits IL-1beta production by a novel mechanism as the inhibitory activity was not due to effects on caspase-1 (IL-1beta converting enzyme), the ATP-induced release mechanism or a lysosomotrophic effect.	LL-Z 1271alpha	28-41	interleukin 1 beta	Homo sapiens	51-59
11892915-6	2001	The targeting of p38 MAPK by VX-745 was associated with the suppression of the release of inflammatory mediators, including interleukin (IL)-1beta and tumor necrosis factor (TNF)alpha, known to be implicated in exacerbating the pathophysiology of RA [273648], [368149], [371548], [372054], [408713].	VX-745	29-35	interleukin 1 beta	Homo sapiens	124-146
11478777-0	2001	Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.	Nitric Oxide	46-58	interleukin 1 beta	Homo sapiens	73-81
11478777-0	2001	Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.	Prostaglandins E	63-66	interleukin 1 beta	Homo sapiens	73-81
11478777-0	2001	Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.	Sepharose	118-125	interleukin 1 beta	Homo sapiens	73-81
11478777-1	2001	Both mechanical loading and interleukin-1beta (IL-1beta) are known to regulate metabolic processes in articular cartilage through pathways mediated by nitric oxide ((*)NO) and PGE(2).	Nitric Oxide	151-163	interleukin 1 beta	Homo sapiens	28-45
11478777-1	2001	Both mechanical loading and interleukin-1beta (IL-1beta) are known to regulate metabolic processes in articular cartilage through pathways mediated by nitric oxide ((*)NO) and PGE(2).	Nitric Oxide	151-163	interleukin 1 beta	Homo sapiens	47-55
11478777-1	2001	Both mechanical loading and interleukin-1beta (IL-1beta) are known to regulate metabolic processes in articular cartilage through pathways mediated by nitric oxide ((*)NO) and PGE(2).	Prostaglandins E	176-179	interleukin 1 beta	Homo sapiens	28-45
11478777-1	2001	Both mechanical loading and interleukin-1beta (IL-1beta) are known to regulate metabolic processes in articular cartilage through pathways mediated by nitric oxide ((*)NO) and PGE(2).	Prostaglandins E	176-179	interleukin 1 beta	Homo sapiens	47-55
11478777-2	2001	This study uses a well-characterized model system involving isolated chondrocytes cultured in agarose constructs to test the hypothesis that dynamic compression alters the synthesis of (*)NO and PGE(2) by IL-1beta-stimulated articular chondrocytes.	Prostaglandins E	195-198	interleukin 1 beta	Homo sapiens	205-213
11478777-3	2001	The data presented demonstrate for the first time that dynamic compression counteracts the effects of IL-1beta on articular chondrocytes by suppressing both (*)NO and PGE(2) synthesis.	Prostaglandins E	167-170	interleukin 1 beta	Homo sapiens	102-110
11780370-6	2001	Levels of plasma endotoxin, serum TNF-alpha, IL-1 beta and total bilirubin (TBiL) were significantly increased in the CSH group.	csh	118-121	interleukin 1 beta	Homo sapiens	45-54
11509336-2	2001	In the current study, we evaluated the hypothesis that a number of inflammatory factors, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, and interferon (IFN)-gamma, modulate this process by induction of prostaglandin (PG) E(2) and nitric oxide (NO) production and that these secondary mediators function in an autocrine or paracrine manner to modulate contraction.	Prostaglandins E	225-245	interleukin 1 beta	Homo sapiens	134-157
11509336-7	2001	PGE(2) production was increased by TNF-alpha (5.0 versus 0.16 ng/ml, P &lt; 0.01), IL-1 beta (5.3 versus 0.16 ng/ml, P &lt; 0.01), and cytomix (5.9 versus 0.16 ng/ml, P &lt; 0.01), and was completely inhibited by indomethacin.	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	83-92
11570587-6	2001	Our studies on the regulation of IL-10 secretion in OVCAR-3 revealed that (1) proinflammatory stimuli IL-1beta and TNF-alpha, but not LPS, enhance IL-10 secretion, (2) IL-6 has no influence on the release of IL-10, (3) prostaglandin E2 influences neither the spontaneous nor the TNF-alpha- or IL-1beta-stimulated IL-10 production and (4) interferon-gamma inhibits IL-10 secretion.	Dinoprostone	219-235	interleukin 1 beta	Homo sapiens	102-110
11556519-8	2001	RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes.	aceclofenac	35-46	interleukin 1 beta	Homo sapiens	228-236
11556519-8	2001	RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes.	4'-hydroxyaceclofenac	48-69	interleukin 1 beta	Homo sapiens	228-236
11556519-8	2001	RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes.	Diclofenac	74-84	interleukin 1 beta	Homo sapiens	228-236
11556519-11	2001	At 30 microM, 4"-hydroxyaceclofenac inhibited both IL-1beta or LPS-stimulated nitric oxide production while diclofenac inhibited only the LPS-stimulated production.	4'-hydroxyaceclofenac	14-35	interleukin 1 beta	Homo sapiens	51-59
11438463-8	2001	The iNOS inhibitor N-monomethylarginine (NMMA) and an inhibitor of tumor necrosis factor receptor-associated factor (TRAF)2 and TRAF6 signaling (the zinc finger protein A20) suppressed IL-1 induction of TGase activity.	n-monomethylarginine	19-39	interleukin 1 beta	Homo sapiens	185-189
11566557-9	2001	No clear-cut results could be established for intracellular cytokine production, only NiSO(4) induced a remarkable number of IL-1 beta-positive cells.	niso	86-90	interleukin 1 beta	Homo sapiens	125-134
11476762-5	2001	However, basal release was significantly augmented in a concentration-dependent manner in cells treated with interleukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha) and inhibited by dexamethasone.	Dexamethasone	199-212	interleukin 1 beta	Homo sapiens	109-126
11476762-5	2001	However, basal release was significantly augmented in a concentration-dependent manner in cells treated with interleukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha) and inhibited by dexamethasone.	Dexamethasone	199-212	interleukin 1 beta	Homo sapiens	128-136
11457450-0	2001	15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.	15-deoxy-delta12	0-16	interleukin 1 beta	Homo sapiens	58-66
11457450-0	2001	15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.	14-pgj2	17-24	interleukin 1 beta	Homo sapiens	58-66
11457450-4	2001	15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2), in contrast to troglitazone, was highly potent to counteract IL-1beta-induced cyclooxygenase-2 and inductible nitric oxide synthase expression, NO production and the decrease in proteoglycan synthesis.	15-deoxy-delta(12,14)-prostaglandin J2	38-46	interleukin 1 beta	Homo sapiens	110-118
11457450-4	2001	15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2), in contrast to troglitazone, was highly potent to counteract IL-1beta-induced cyclooxygenase-2 and inductible nitric oxide synthase expression, NO production and the decrease in proteoglycan synthesis.	Troglitazone	64-76	interleukin 1 beta	Homo sapiens	110-118
11401841-6	2001	Addition of interleukin-1beta to serum enhanced COX-2 expression and PGE2 synthesis over that by serum alone but had no effect on the progression of these cells into S phase.	Dinoprostone	69-73	interleukin 1 beta	Homo sapiens	12-29
11522023-7	2001	Interleukin-1beta (IL-1beta), basic fibroblast growth factor (bFGF) or vascular endothelial growth factor increased suPAR release from endothelial cells, whereas platelet derived growth factor-BB, bFGF or IL-1beta stimulated suPAR release from vascular smooth muscle cells.	supar	116-121	interleukin 1 beta	Homo sapiens	0-17
11522023-7	2001	Interleukin-1beta (IL-1beta), basic fibroblast growth factor (bFGF) or vascular endothelial growth factor increased suPAR release from endothelial cells, whereas platelet derived growth factor-BB, bFGF or IL-1beta stimulated suPAR release from vascular smooth muscle cells.	supar	116-121	interleukin 1 beta	Homo sapiens	19-27
11522023-7	2001	Interleukin-1beta (IL-1beta), basic fibroblast growth factor (bFGF) or vascular endothelial growth factor increased suPAR release from endothelial cells, whereas platelet derived growth factor-BB, bFGF or IL-1beta stimulated suPAR release from vascular smooth muscle cells.	supar	225-230	interleukin 1 beta	Homo sapiens	0-17
11500085-5	2001	Cell surface stimulation of CD23 expressed by astrocytes induced production of nitric oxide (NO) and IL-1beta which was inhibited by a specific inducible NO-synthase (iNOS) inhibitor (aminoguanidine), indicating the implication of this receptor in the astrocyte inflammatory reaction.	pimagedine	184-198	interleukin 1 beta	Homo sapiens	101-109
11438463-8	2001	The iNOS inhibitor N-monomethylarginine (NMMA) and an inhibitor of tumor necrosis factor receptor-associated factor (TRAF)2 and TRAF6 signaling (the zinc finger protein A20) suppressed IL-1 induction of TGase activity.	nmma	41-45	interleukin 1 beta	Homo sapiens	185-189
11447387-10	2001	Budesonide caused a dose-related inhibition of lactoferrin secretion induced by IL-1beta (down to -76%) and TNF-alpha (down to -70%), whereas IL-10 had no effect.	Budesonide	0-10	interleukin 1 beta	Homo sapiens	80-88
11399259-4	2001	Two weeks after the procedure, coronary stenotic lesions with constrictive remodeling and vasospastic response to serotonin were noted at the IL-1beta-treated site, as previously reported.	Serotonin	114-123	interleukin 1 beta	Homo sapiens	142-150
11414749-5	2001	In addition, cytotoxicity, superoxide anion release, and TNF-alpha and IL-1beta production were enhanced in TB-PMN.	tb-pmn	108-114	interleukin 1 beta	Homo sapiens	71-79
11404058-4	2001	Interferon-gamma, phorbol myristate acetate and interleukin-6 all stimulated C9 mRNA expression but the inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, as well as the anaphylatoxin C5a and the bacterial lipopolysaccharide, were ineffective.	Tetradecanoylphorbol Acetate	18-43	interleukin 1 beta	Homo sapiens	156-174
11426981-7	2001	Moreover, coincubation of OVCAR-3 and HOC-7 with the specific iNOS inhibitor aminoguanidine suppressed apoptosis induced by IFN-gamma, IL-1beta, and TNF-alpha.	pimagedine	77-91	interleukin 1 beta	Homo sapiens	135-143
11566622-6	2001	Local application of IL-1beta led to increases in adhesion, chemotaxis, oxygen radical production and phagocytosis of abscess fluid neutrophils.	Reactive Oxygen Species	72-86	interleukin 1 beta	Homo sapiens	21-29
11495136-16	2001	A positive statistical correlation was detected between the total IL-1beta and TBARS levels in the APT group.	Thiobarbituric Acid Reactive Substances	79-84	interleukin 1 beta	Homo sapiens	66-74
11418684-3	2001	Northern blot analysis showed that IL-1beta or TNF-alpha treatment induces mPGES mRNA from very low levels at baseline to maximum levels at 24 h. IL-1beta-induced mPGES mRNA was inhibited by dexamethasone in a dose-dependent fashion.	Dexamethasone	191-204	interleukin 1 beta	Homo sapiens	35-43
11418684-3	2001	Northern blot analysis showed that IL-1beta or TNF-alpha treatment induces mPGES mRNA from very low levels at baseline to maximum levels at 24 h. IL-1beta-induced mPGES mRNA was inhibited by dexamethasone in a dose-dependent fashion.	Dexamethasone	191-204	interleukin 1 beta	Homo sapiens	146-154
11418684-6	2001	The detected mPGES protein was catalytically functional as indicated by a 3-fold increase of PGES activity in synoviocytes following treatment with IL-1beta; this increased synthase activity was limited to the microsomal fraction.	Prostaglandins E	14-18	interleukin 1 beta	Homo sapiens	148-156
11418687-0	2001	Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes.	gamma-Linolenic Acid	0-19	interleukin 1 beta	Homo sapiens	106-115
11418687-0	2001	Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes.	Fatty Acids, Unsaturated	24-46	interleukin 1 beta	Homo sapiens	106-115
11418687-2	2001	Addition of GLA in vitro suppresses release of IL-1beta from human monocytes stimulated with LPS.	gamma-Linolenic Acid	12-15	interleukin 1 beta	Homo sapiens	47-55
11418687-4	2001	We show here with peripheral blood monocytes from normal volunteers and from patients with rheumatoid arthritis by using IL-1R antagonist to block autoinduction and IL-1alpha stimulation to simulate autoinduction that approximately 40% of IL-1beta released from LPS-stimulated cells is attributable to autoinduction and that GLA reduces autoinduction of IL-1beta while leaving the initial IL-1beta response to LPS intact.	gamma-Linolenic Acid	325-328	interleukin 1 beta	Homo sapiens	239-247
11418687-5	2001	Experiments with cells in which transcription and protein synthesis were blocked suggest that GLA induces a protein that reduces pro-IL-1beta mRNA stability.	gamma-Linolenic Acid	94-97	interleukin 1 beta	Homo sapiens	133-141
11469463-2	2001	We now investigate the mechanism by which PUVA therapy is effective by comparing interleukin 1beta (IL-1beta) mediated signal transduction in scleroderma fibroblasts and those from normal skin.	puva	42-46	interleukin 1 beta	Homo sapiens	81-98
11469463-2	2001	We now investigate the mechanism by which PUVA therapy is effective by comparing interleukin 1beta (IL-1beta) mediated signal transduction in scleroderma fibroblasts and those from normal skin.	puva	42-46	interleukin 1 beta	Homo sapiens	100-108
11469463-6	2001	RESULTS: Constitutive PGE2 production was significantly upregulated and IL-1beta induced PGE2 production was increased by the enhancing expression of both COX-2 mRNA and protein in fibroblasts from scleroderma involved skin; PGE2 production and COX-2 expression were inhibited by UVA irradiation.	Dinoprostone	89-93	interleukin 1 beta	Homo sapiens	72-80
11469463-6	2001	RESULTS: Constitutive PGE2 production was significantly upregulated and IL-1beta induced PGE2 production was increased by the enhancing expression of both COX-2 mRNA and protein in fibroblasts from scleroderma involved skin; PGE2 production and COX-2 expression were inhibited by UVA irradiation.	Dinoprostone	89-93	interleukin 1 beta	Homo sapiens	72-80
11467894-9	2001	RESULTS: IL-1beta suppressed aggrecan synthesis by chondrocytes in agarose.	Sepharose	67-74	interleukin 1 beta	Homo sapiens	9-17
11433182-6	2001	The plasma antiinflammatory cytokine such as IL-1b and oxygen radical-mediated lipid peroxidation was measured in the ulcerated gastric mucosa of ASA and NO-ASA-treated animals.	Aspirin	146-149	interleukin 1 beta	Homo sapiens	45-50
11433182-6	2001	The plasma antiinflammatory cytokine such as IL-1b and oxygen radical-mediated lipid peroxidation was measured in the ulcerated gastric mucosa of ASA and NO-ASA-treated animals.	Aspirin	157-160	interleukin 1 beta	Homo sapiens	45-50
11455208-4	2001	TNF-alpha and IL-1beta activated p44/42 and p38 mitogen-activated protein kinases (MAPKs) in HUVECs; this was inhibited by the specific inhibitors of these kinases, PD98059 and SB202190, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	165-172	interleukin 1 beta	Homo sapiens	14-22
11455208-5	2001	Pretreatment of endothelial cells with the specific p38 MAPK inhibitor SB202190 (5 microM) or hydrocortisone (5 microM) partly reversed the suppression of ACE by TNF-alpha or IL-1beta, whereas the specific p44/42 MAPK inhibitor PD98059 (40 microM) was without effect.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	71-79	interleukin 1 beta	Homo sapiens	175-183
11455208-5	2001	Pretreatment of endothelial cells with the specific p38 MAPK inhibitor SB202190 (5 microM) or hydrocortisone (5 microM) partly reversed the suppression of ACE by TNF-alpha or IL-1beta, whereas the specific p44/42 MAPK inhibitor PD98059 (40 microM) was without effect.	Hydrocortisone	94-108	interleukin 1 beta	Homo sapiens	175-183
11467894-17	2001	IL-1beta-induced changes in CAM aggrecan and hyaluronan closely agreed.	Hyaluronic Acid	45-55	interleukin 1 beta	Homo sapiens	0-8
11449408-8	2001	The spontaneous intracellular production in molecules of equivalent soluble fluorochrome units (MESF) of IL-1beta, IL-6, and TNF-alpha after 8 h of culture was higher in brefeldin A than in monensin-inhibited monocytes.	Brefeldin A	170-181	interleukin 1 beta	Homo sapiens	105-113
11439237-5	2001	Treatment with the typical neuroleptics haloperidol and perazine decreased the release of IL- 1 beta and TNF-alpha to the control levels.	Haloperidol	40-51	interleukin 1 beta	Homo sapiens	90-100
11390507-2	2001	Minocycline, a tetracycline derivative with antiinflammatory effects, inhibits IL-1beta-converting enzyme and inducible nitric oxide synthase up-regulation in animal models of ischemic stroke and Huntington"s disease and is therapeutic in these disease animal models.	Minocycline	0-11	interleukin 1 beta	Homo sapiens	79-87
11390507-6	2001	Minocycline also prevented the NMDA-induced proliferation of microglial cells and the increased release of IL-1beta and nitric oxide in pure microglia cultures.	Minocycline	0-11	interleukin 1 beta	Homo sapiens	107-115
11439237-5	2001	Treatment with the typical neuroleptics haloperidol and perazine decreased the release of IL- 1 beta and TNF-alpha to the control levels.	Perazine	56-64	interleukin 1 beta	Homo sapiens	90-100
11290751-3	2001	Nevertheless, we found that the cathepsin B inhibitor benzyloxycarbonyl-Phe-Ala-fluoromethylketone (z-FA.fmk) prevents LPS-induced production of IL-1alpha, IL-1beta, and tumor necrosis factor at the transcriptional level.	benzyloxycarbonyl-phe-ala-fluoromethylketone	54-98	interleukin 1 beta	Homo sapiens	156-164
11290751-3	2001	Nevertheless, we found that the cathepsin B inhibitor benzyloxycarbonyl-Phe-Ala-fluoromethylketone (z-FA.fmk) prevents LPS-induced production of IL-1alpha, IL-1beta, and tumor necrosis factor at the transcriptional level.	z-fa	100-104	interleukin 1 beta	Homo sapiens	156-164
11290751-3	2001	Nevertheless, we found that the cathepsin B inhibitor benzyloxycarbonyl-Phe-Ala-fluoromethylketone (z-FA.fmk) prevents LPS-induced production of IL-1alpha, IL-1beta, and tumor necrosis factor at the transcriptional level.	FMK	105-108	interleukin 1 beta	Homo sapiens	156-164
11516436-4	2001	Intraplantar injection of interleukin-1beta into the hindpaw elicited mechanical hyperalgesia in the ipsilateral paw, as well as in the contralateral paw, following intraplantar injection of the bradykinin B(1) receptor agonist des-Arg(9)-bradykinin.	des-arg	228-235	interleukin 1 beta	Homo sapiens	26-43
11516436-5	2001	Oral administration of SB203580 1 h prior to interleukin-1beta administration prevented the development of hyperalgesia in the ipslateral paw and the contralateral bradykinin B(1) receptor-mediated hyperalgesia.	SB 203580	23-31	interleukin 1 beta	Homo sapiens	45-62
11449408-8	2001	The spontaneous intracellular production in molecules of equivalent soluble fluorochrome units (MESF) of IL-1beta, IL-6, and TNF-alpha after 8 h of culture was higher in brefeldin A than in monensin-inhibited monocytes.	Monensin	190-198	interleukin 1 beta	Homo sapiens	105-113
11449408-9	2001	The LPS-stimulated intracellular production of IL-1beta, IL-6, and TNF-alpha was increased in brefeldin A-inhibited monocytes.	Brefeldin A	94-105	interleukin 1 beta	Homo sapiens	47-55
11516436-6	2001	In addition, following interleukin-1beta injection into the ipsilateral paw, co-administration of SB203580 with des-Arg(9)-bradykinin into the contralateral paw inhibited the bradykinin B(1) receptor-mediated hyperalgesia.	SB 203580	98-106	interleukin 1 beta	Homo sapiens	23-40
11404398-3	2001	Using reporter constructs and electromobility shift assays, we found that cotreatment of astrocyte cultures with ATP (1-100 microm) significantly potentiated IL-1beta-mediated activation of NF-kappaB and AP-1 and that ATP alone activated AP-1.	Adenosine Triphosphate	113-116	interleukin 1 beta	Homo sapiens	158-166
11404398-5	2001	A role for ATP in modulating IL-1beta-mediated inflammatory gene expression was supported further by the observation that ATP potentiated the IL-1beta-induced expression of IL-8 mRNA and protein but strongly downregulated IP-10 expression.	Adenosine Triphosphate	11-14	interleukin 1 beta	Homo sapiens	29-37
11449408-10	2001	In conclusion, for flow cytometric determination of intracellular monocytic cytokines (IL-1beta, IL-6, and TNF-alpha), brefeldin A is a more potent, effective, and less toxic inhibitor of cytokine secretion than monensin.	Brefeldin A	119-130	interleukin 1 beta	Homo sapiens	87-95
11404398-5	2001	A role for ATP in modulating IL-1beta-mediated inflammatory gene expression was supported further by the observation that ATP potentiated the IL-1beta-induced expression of IL-8 mRNA and protein but strongly downregulated IP-10 expression.	Adenosine Triphosphate	11-14	interleukin 1 beta	Homo sapiens	142-150
11404398-5	2001	A role for ATP in modulating IL-1beta-mediated inflammatory gene expression was supported further by the observation that ATP potentiated the IL-1beta-induced expression of IL-8 mRNA and protein but strongly downregulated IP-10 expression.	Adenosine Triphosphate	122-125	interleukin 1 beta	Homo sapiens	29-37
11404398-5	2001	A role for ATP in modulating IL-1beta-mediated inflammatory gene expression was supported further by the observation that ATP potentiated the IL-1beta-induced expression of IL-8 mRNA and protein but strongly downregulated IP-10 expression.	Adenosine Triphosphate	122-125	interleukin 1 beta	Homo sapiens	142-150
11274209-6	2001	This regulation of NF-kappaB activation by PKCdelta was specific only for TNFalpha signaling, since lipopolysaccharide- or interleukin-1beta-induced NF-kappaB activation and IkappaBalpha degradation were not inhibited by rottlerin.	rottlerin	221-230	interleukin 1 beta	Homo sapiens	123-140
11408847-0	2001	The effects of intrapartum magnesium sulfate therapy on fetal serum interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha at delivery: a randomized, placebo-controlled trial.	Magnesium Sulfate	27-44	interleukin 1 beta	Homo sapiens	68-85
11350802-7	2001	However, OSM caused dose-dependent augmentation of COX-2 expression and prostaglandin (PG) E(2) release induced by IL-1beta.	Dinoprostone	72-95	interleukin 1 beta	Homo sapiens	115-123
11350802-9	2001	IL-6 did increase IL-1beta-induced PGE(2) formation in unstimulated cells but not in cells stimulated with arachidonic acid (AA; 10(-5) M), suggesting that IL-6 effects were mediated at the level of AA release.	Prostaglandins E	35-38	interleukin 1 beta	Homo sapiens	18-26
11350802-11	2001	In addition, OSM and IL-1beta synergistically cause COX-2 expression and PGE(2) release.	Prostaglandins E	73-76	interleukin 1 beta	Homo sapiens	21-29
11408847-3	2001	The purpose of this study was to determine whether intrapartum magnesium sulfate therapy has an effect on the umbilical venous concentrations of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha at delivery.	Magnesium Sulfate	63-80	interleukin 1 beta	Homo sapiens	145-162
11352510-1	2001	We have previously demonstrated that bradykinin potentiates prostaglandin E(2)release in human gingival fibroblasts pretreated with interleukin-1 beta (priming).	Dinoprostone	60-78	interleukin 1 beta	Homo sapiens	132-150
11426771-6	2001	Interleukin 1beta, interleukin 6, and interleukin 8 levels after cardiopulmonary bypass were significantly (p &lt; 0.05) lower in the colforsin group.	Colforsin	134-143	interleukin 1 beta	Homo sapiens	0-17
11477478-4	2001	Carriage of the rare IL-1B (+3954) allele 2 was increased in destructive arthritis (DRA) as compared to non-destructive arthritis (NDRA) (OR 1.7, 95% CI 1.1-2.8, 49.0% vs 35.9%) and controls (OR 1.7, 95% CI 1.1-2.8, 35.8%).	dra	84-87	interleukin 1 beta	Homo sapiens	21-26
11403206-7	2001	PARP inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression, and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h. These experiments suggest that specific PARP inhibition may provide a novel method of controlling leukocyte dependent inflammation through the reduction of ICAM-1 and E-selectin expression in endothelial cells in response to cytokines.	GPI 6150	21-29	interleukin 1 beta	Homo sapiens	42-50
11758807-4	2001	PA activity in the cell lysate was increased by treatment with IL-1beta.	Protactinium	0-2	interleukin 1 beta	Homo sapiens	63-71
11758807-5	2001	Further, PA activity released by phosphatidylinositol-specific phospholipase C, which detaches the GPI anchor, was also increased by IL-1beta.	Protactinium	9-11	interleukin 1 beta	Homo sapiens	133-141
11758807-5	2001	Further, PA activity released by phosphatidylinositol-specific phospholipase C, which detaches the GPI anchor, was also increased by IL-1beta.	Phosphatidylinositols	33-53	interleukin 1 beta	Homo sapiens	133-141
11278846-2	2001	This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-acetate and interleukin 1beta by inhibiting the binding of CCAAT/enhancer-binding protein beta to its promoter region of COX-2.	Sodium Salicylate	29-46	interleukin 1 beta	Homo sapiens	161-178
11352510-6	2001	Dexamethasone and actinomycin D completely suppressed not only the interleukin-1 beta-induced cyclooxygenase-2 mRNA expression, but also the bradykinin-induced cyclooxygenase-2 mRNA expression in the interleukin-1 beta-primed fibroblasts, although cycloheximide did not inhibit the effects of interleukin-1 beta and bradykinin.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	67-85
11352510-6	2001	Dexamethasone and actinomycin D completely suppressed not only the interleukin-1 beta-induced cyclooxygenase-2 mRNA expression, but also the bradykinin-induced cyclooxygenase-2 mRNA expression in the interleukin-1 beta-primed fibroblasts, although cycloheximide did not inhibit the effects of interleukin-1 beta and bradykinin.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	200-218
11352510-6	2001	Dexamethasone and actinomycin D completely suppressed not only the interleukin-1 beta-induced cyclooxygenase-2 mRNA expression, but also the bradykinin-induced cyclooxygenase-2 mRNA expression in the interleukin-1 beta-primed fibroblasts, although cycloheximide did not inhibit the effects of interleukin-1 beta and bradykinin.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	200-218
11352510-6	2001	Dexamethasone and actinomycin D completely suppressed not only the interleukin-1 beta-induced cyclooxygenase-2 mRNA expression, but also the bradykinin-induced cyclooxygenase-2 mRNA expression in the interleukin-1 beta-primed fibroblasts, although cycloheximide did not inhibit the effects of interleukin-1 beta and bradykinin.	Dactinomycin	18-31	interleukin 1 beta	Homo sapiens	67-85
11352510-6	2001	Dexamethasone and actinomycin D completely suppressed not only the interleukin-1 beta-induced cyclooxygenase-2 mRNA expression, but also the bradykinin-induced cyclooxygenase-2 mRNA expression in the interleukin-1 beta-primed fibroblasts, although cycloheximide did not inhibit the effects of interleukin-1 beta and bradykinin.	Dactinomycin	18-31	interleukin 1 beta	Homo sapiens	200-218
11352510-6	2001	Dexamethasone and actinomycin D completely suppressed not only the interleukin-1 beta-induced cyclooxygenase-2 mRNA expression, but also the bradykinin-induced cyclooxygenase-2 mRNA expression in the interleukin-1 beta-primed fibroblasts, although cycloheximide did not inhibit the effects of interleukin-1 beta and bradykinin.	Dactinomycin	18-31	interleukin 1 beta	Homo sapiens	200-218
11352510-6	2001	Dexamethasone and actinomycin D completely suppressed not only the interleukin-1 beta-induced cyclooxygenase-2 mRNA expression, but also the bradykinin-induced cyclooxygenase-2 mRNA expression in the interleukin-1 beta-primed fibroblasts, although cycloheximide did not inhibit the effects of interleukin-1 beta and bradykinin.	Cycloheximide	248-261	interleukin 1 beta	Homo sapiens	67-85
11352510-7	2001	These results suggest that bradykinin-induced prostaglandin E2 synthesis is regulated at the level of the transcription of cyclooxygenase-2 mRNA via Ca2+ mobilization in the interleukin-1 beta-primed human gingival fibroblasts.	Dinoprostone	46-62	interleukin 1 beta	Homo sapiens	174-192
11319753-5	2001	SB 203580, a selective inhibitor of p38 MAPK, inhibited IL-1 and TNF-induced p38 MAPK activity and IL-6 production (IC(50)s 0.3--0.5 microM) in osteoblasts and chondrocytes.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	56-60
11378323-7	2001	We found that 0.5 M NaCl treatment increased mRNA levels of proinflammatory cytokines such as IL-1alpha, IL-6 and IL-8 as well as ICAM-1 in NHEK and IL-1alpha, IL-1beta and IL-6 mRNA levels in NHDF.	Sodium Chloride	20-24	interleukin 1 beta	Homo sapiens	160-168
11397893-0	2001	Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	73-91
11397893-7	2001	Dex inhibited TNFalpha-induced messenger ribonucleic acid expression of ICE, TNF alpha, and IL-1 beta (P &lt; 0.01), but not that of bcl-2 and NF kappa B.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	92-101
23345738-1	2001	Kinetic data measured from folding of the protein interleukin-1beta fits best to three exponential phases when studied with tryptophan fluorescence but only two exponential phases when measured using other methods.	Tryptophan	124-134	interleukin 1 beta	Homo sapiens	50-67
23345738-5	2001	Protein concentration-dependent folding studies demonstrate that, at lower interleukin-1beta concentrations, tryptophan fluorescence kinetics can be fit adequately with a two exponential fit.	Tryptophan	109-119	interleukin 1 beta	Homo sapiens	75-92
11393780-5	2001	In MG-63 cells, interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently inhibited 11beta-HSD2 activity (cortisol-cortisone conversion) and messenger RNA (mRNA) levels in a dose-dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity (cortisone-cortisol conversion).	Hydrocortisone	130-138	interleukin 1 beta	Homo sapiens	16-33
11393780-5	2001	In MG-63 cells, interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently inhibited 11beta-HSD2 activity (cortisol-cortisone conversion) and messenger RNA (mRNA) levels in a dose-dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity (cortisone-cortisol conversion).	Hydrocortisone	130-138	interleukin 1 beta	Homo sapiens	35-43
11393780-5	2001	In MG-63 cells, interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently inhibited 11beta-HSD2 activity (cortisol-cortisone conversion) and messenger RNA (mRNA) levels in a dose-dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity (cortisone-cortisol conversion).	Cortisone	139-148	interleukin 1 beta	Homo sapiens	16-33
11393780-5	2001	In MG-63 cells, interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently inhibited 11beta-HSD2 activity (cortisol-cortisone conversion) and messenger RNA (mRNA) levels in a dose-dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity (cortisone-cortisol conversion).	Cortisone	139-148	interleukin 1 beta	Homo sapiens	35-43
11393780-5	2001	In MG-63 cells, interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently inhibited 11beta-HSD2 activity (cortisol-cortisone conversion) and messenger RNA (mRNA) levels in a dose-dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity (cortisone-cortisol conversion).	Cortisone	294-303	interleukin 1 beta	Homo sapiens	16-33
11393780-5	2001	In MG-63 cells, interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently inhibited 11beta-HSD2 activity (cortisol-cortisone conversion) and messenger RNA (mRNA) levels in a dose-dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity (cortisone-cortisol conversion).	Cortisone	294-303	interleukin 1 beta	Homo sapiens	35-43
11393780-5	2001	In MG-63 cells, interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently inhibited 11beta-HSD2 activity (cortisol-cortisone conversion) and messenger RNA (mRNA) levels in a dose-dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity (cortisone-cortisol conversion).	Hydrocortisone	304-312	interleukin 1 beta	Homo sapiens	16-33
11393780-5	2001	In MG-63 cells, interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently inhibited 11beta-HSD2 activity (cortisol-cortisone conversion) and messenger RNA (mRNA) levels in a dose-dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity (cortisone-cortisol conversion).	Hydrocortisone	304-312	interleukin 1 beta	Homo sapiens	35-43
11389189-6	2001	IFN-beta decreased HO-1 expression and mitochondrial iron sequestration in IL-1beta- and TNF-alpha-challenged astroglia.	Iron	53-57	interleukin 1 beta	Homo sapiens	75-83
11529335-11	2001	The levels of IL-1beta were very low, although IL-1beta was detectable in the group treated with RVV at a concentration of 25.0 microg/ml.	2,4-dimethylpyridine	97-100	interleukin 1 beta	Homo sapiens	47-55
11399109-4	2001	Through the release of histamine and other mediators and their effects on the mast cell-leukocyte cytokine cascade, immune stimuli in susceptible persons increase allergic inflammation and magnify stressors" effects through the release of HPA-axis-activating cytokines, such as IL-1beta, that drive the axis and reinforce the physiological and behavioral effects.	Histamine	23-32	interleukin 1 beta	Homo sapiens	278-286
11453112-0	2001	Prostaglandin E2 secretion from gingival fibroblasts treated with interleukin-1beta: effects of lipid extracts from Porphyromonas gingivalis or calculus.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	66-83
11453112-6	2001	Control and lipid-treated cultures were exposed to human recombinant interleukin-1beta for 48 h and prostaglandin secretion from interleukin-1beta-treated fibroblasts was compared with control and lipid-treated fibroblasts without interleukin-1beta treatment.	Prostaglandins	100-113	interleukin 1 beta	Homo sapiens	129-146
11453112-6	2001	Control and lipid-treated cultures were exposed to human recombinant interleukin-1beta for 48 h and prostaglandin secretion from interleukin-1beta-treated fibroblasts was compared with control and lipid-treated fibroblasts without interleukin-1beta treatment.	Prostaglandins	100-113	interleukin 1 beta	Homo sapiens	129-146
11453112-7	2001	These experiments demonstrated that P. gingivalis lipids or calculus-tooth lipids potentiate interleukin-1beta-mediated prostaglandin secretory responses from gingival fibroblasts.	Prostaglandins	120-133	interleukin 1 beta	Homo sapiens	93-110
11453113-6	2001	Stimulation of collagenase-2 mRNA expression by IL-1beta was prevented by pretreatment with cycloheximide, an inhibitor of protein synthesis.	Cycloheximide	92-105	interleukin 1 beta	Homo sapiens	48-56
12585120-5	2001	RESULTS: Hydrocortisone inhibited TNF-alpha (50 U.mL-1 for 12 hours) and IL-1 beta (50 U.mL-1 for 12 hours)-induced adhesion of PMN to HSC (IC50 2.05 x 10(-6) mol.L-1 and 2.13 x 10(-7) mol.L-1, respectively) in a concentration-dependent manner.	Hydrocortisone	9-23	interleukin 1 beta	Homo sapiens	73-82
11545246-9	2001	The low LM values at high IL-1ra/IL-1beta ratios in PBMC cultures from healthy donors, reversed proportions found in patients" PBMC (acute tonsilitis), and the cefaclor-induced reduction of LM value with correlated increase of the IL-1ra/IL-1beta ratio suggest that the LM assay may prove to be useful for immunodiagnostic purposes.	Cefaclor	160-168	interleukin 1 beta	Homo sapiens	33-41
11545246-9	2001	The low LM values at high IL-1ra/IL-1beta ratios in PBMC cultures from healthy donors, reversed proportions found in patients" PBMC (acute tonsilitis), and the cefaclor-induced reduction of LM value with correlated increase of the IL-1ra/IL-1beta ratio suggest that the LM assay may prove to be useful for immunodiagnostic purposes.	Cefaclor	160-168	interleukin 1 beta	Homo sapiens	238-246
11333849-8	2001	RESULTS: Pretreatment of HAEC with (+)-catechin metabolites inhibited U937 cell adhesion to IL-1 beta-stimulated cells, whereas pretreatment with intact (+)-catechin had no effect.	Catechin	35-47	interleukin 1 beta	Homo sapiens	92-101
11342615-7	2001	In addition, histamine induces a potent production of IL-6, IL-8, monocyte chemoattractant protein 1, and macrophage-inflammatory protein 1alpha by immature DC and also up-regulates IL-1beta, RANTES, and macrophage-inflammatory protein 1beta but not TNF-alpha and IL-12 mRNA expression.	Histamine	13-22	interleukin 1 beta	Homo sapiens	182-190
11279137-7	2001	Similarly, lactacystin protected against endothelial apoptosis induced by either tumor necrosis factor-alpha or interleukin-1beta in the presence of cycloheximide.	lactacystin	11-22	interleukin 1 beta	Homo sapiens	112-129
11350835-3	2001	Chronic incubation with IL-1beta or RV caused a significant increase (approximately 3- and approximately 2-fold, respectively) in forskolin (FSK)-stimulated cAMP production, suggesting a sensitization of adenylyl cyclase (AC).	Colforsin	130-139	interleukin 1 beta	Homo sapiens	24-32
11350835-3	2001	Chronic incubation with IL-1beta or RV caused a significant increase (approximately 3- and approximately 2-fold, respectively) in forskolin (FSK)-stimulated cAMP production, suggesting a sensitization of adenylyl cyclase (AC).	Colforsin	141-144	interleukin 1 beta	Homo sapiens	24-32
11350835-3	2001	Chronic incubation with IL-1beta or RV caused a significant increase (approximately 3- and approximately 2-fold, respectively) in forskolin (FSK)-stimulated cAMP production, suggesting a sensitization of adenylyl cyclase (AC).	Cyclic AMP	157-161	interleukin 1 beta	Homo sapiens	24-32
11350835-4	2001	The observed augmentation of FSK-stimulated cAMP formation by IL-1beta was completely abrogated by pretreatment with an IL-1 receptor antagonist or cycloheximide, demonstrating that the effect is mediated via the IL-1 receptor 1 (IL-1R1) and that de novo protein synthesis is required.	Colforsin	29-32	interleukin 1 beta	Homo sapiens	62-70
11350835-4	2001	The observed augmentation of FSK-stimulated cAMP formation by IL-1beta was completely abrogated by pretreatment with an IL-1 receptor antagonist or cycloheximide, demonstrating that the effect is mediated via the IL-1 receptor 1 (IL-1R1) and that de novo protein synthesis is required.	Cyclic AMP	44-48	interleukin 1 beta	Homo sapiens	62-70
11350835-4	2001	The observed augmentation of FSK-stimulated cAMP formation by IL-1beta was completely abrogated by pretreatment with an IL-1 receptor antagonist or cycloheximide, demonstrating that the effect is mediated via the IL-1 receptor 1 (IL-1R1) and that de novo protein synthesis is required.	Cycloheximide	148-161	interleukin 1 beta	Homo sapiens	62-70
11352241-5	2001	Additionally, CDDO reduced IL-1beta-mediated invasion of cells through a collagen matrix.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	14-18	interleukin 1 beta	Homo sapiens	27-35
11311010-4	2001	In this study we have investigated the capacity of a range of different DBM preparations, and ECl dilutions, to induce the production of three pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and tumour necrosis factor alpha (TNF-alpha) from human peripheral blood mononuclear cells (PBMNCs).	dbm	72-75	interleukin 1 beta	Homo sapiens	193-210
11446745-2	2001	IL-1beta up-regulation is not dependent on PKC but the PKC activator PMA induces low levels of GM-CSF production and acts synergistically with IL-1beta to further increase GM-CSF.	Tetradecanoylphorbol Acetate	69-72	interleukin 1 beta	Homo sapiens	0-8
11333849-9	2001	Generation of ROS in hydrogen peroxide-stimulated HAEC was inhibited by (+)-catechin, its metabolites, and control plasma extract, whereas ROS generation in IL-1 beta-stimulated HAEC was inhibited by (+)-catechin metabolites only.	Reactive Oxygen Species	139-142	interleukin 1 beta	Homo sapiens	157-166
11446745-3	2001	Although A23187 and ionomycin stimulated low levels of GM-CSF production, the IL-1beta pathway was cyclosporin A insensitive and did not interact with the calcium pathway.	Cyclosporine	99-112	interleukin 1 beta	Homo sapiens	78-86
11333849-9	2001	Generation of ROS in hydrogen peroxide-stimulated HAEC was inhibited by (+)-catechin, its metabolites, and control plasma extract, whereas ROS generation in IL-1 beta-stimulated HAEC was inhibited by (+)-catechin metabolites only.	Catechin	200-212	interleukin 1 beta	Homo sapiens	157-166
11446747-3	2001	Here, we demonstrate that hypoestoxide (HE) abrogates the production of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lipopolysaccharide (LPS)-activated normal human peripheral blood mononuclear cells.	hypoestoxide	26-38	interleukin 1 beta	Homo sapiens	100-108
11333849-10	2001	In contrast, quercetin inhibited U937 cell adhesion to IL-1 beta-stimulated HAEC, whereas its metabolites were not effective.	Quercetin	13-22	interleukin 1 beta	Homo sapiens	55-64
11446747-3	2001	Here, we demonstrate that hypoestoxide (HE) abrogates the production of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lipopolysaccharide (LPS)-activated normal human peripheral blood mononuclear cells.	hypoestoxide	40-42	interleukin 1 beta	Homo sapiens	100-108
11380138-4	2001	We have used the agarose system to demonstrate the differential effects of oxidised and non-oxidised PE particles on the release of proinflammatory products such as interleukin-1beta (IL-1beta), IL-6, and tumour necrosis factor-alpha (TNF-alpha) from monocytes/macrophages (M/M).	Polyethylene	101-103	interleukin 1 beta	Homo sapiens	165-182
11446747-4	2001	Moreover, HE inhibits the production of nitric oxide (NO) by IL-1beta- or IL-17-stimulated normal human chondrocytes.	Nitric Oxide	40-52	interleukin 1 beta	Homo sapiens	61-69
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 beta	Homo sapiens	362-371
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	122-125	interleukin 1 beta	Homo sapiens	362-371
11358991-6	2001	Pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB activation, attenuated approximately 70% of IL-8 release evoked by IL-1beta, TNF-alpha, or ONOO(-).	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Homo sapiens	122-130
11325794-5	2001	In alveolar epithelial cells, pre-treatment (30 min) with Y-40138 reduced LPS-induced biosynthesis of IL-1 beta, IL-6 and TNF-alpha, an effect paralleled by up-regulating an anti-inflammatory counter-loop mediated through IL-10.	Y 39041	58-65	interleukin 1 beta	Homo sapiens	102-111
11376874-8	2001	Retinoic acid elicited synergistic effects on the CNP secretion rate from HL-60 cells when administered with lipopolysaccharide, interferon-gamma, interleukin-1beta, tumor necrosis factor-alpha, or phorbol ester.	Tretinoin	0-13	interleukin 1 beta	Homo sapiens	147-193
11340103-9	2001	Overall, this study provides evidence that administration of pharmacologic doses of biotin for 14 d decreases PBMC proliferation and synthesis of interleukin-1beta and interleukin-2.	Biotin	84-90	interleukin 1 beta	Homo sapiens	146-163
11358991-2	2001	Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood.	Peroxynitrous Acid	20-33	interleukin 1 beta	Homo sapiens	140-148
11358991-2	2001	Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood.	onoo	35-39	interleukin 1 beta	Homo sapiens	140-148
11358991-2	2001	Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood.	Superoxides	76-86	interleukin 1 beta	Homo sapiens	140-148
11358991-3	2001	The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha.	pimagedine	27-41	interleukin 1 beta	Homo sapiens	318-326
11358991-3	2001	The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha.	NG-Nitroarginine Methyl Ester	46-80	interleukin 1 beta	Homo sapiens	318-326
11358991-4	2001	Enhanced ONOO(-) formation was detected in granulocytes, monocytes, and lymphocytes after challenge with IL-1beta or TNF-alpha.	onoo(-)	9-16	interleukin 1 beta	Homo sapiens	105-113
11380138-4	2001	We have used the agarose system to demonstrate the differential effects of oxidised and non-oxidised PE particles on the release of proinflammatory products such as interleukin-1beta (IL-1beta), IL-6, and tumour necrosis factor-alpha (TNF-alpha) from monocytes/macrophages (M/M).	Polyethylene	101-103	interleukin 1 beta	Homo sapiens	184-192
11306611-6	2001	Minocycline prevented excitotoxin-induced microglial proliferation and the increased release of nitric oxide (NO) metabolites and IL-1beta.	Minocycline	0-11	interleukin 1 beta	Homo sapiens	130-138
11399097-0	2001	Nimesulide reduces interleukin-1beta-induced cyclooxygenase-2 gene expression in human synovial fibroblasts.	nimesulide	0-10	interleukin 1 beta	Homo sapiens	19-36
11399097-9	2001	Pre-treatment of cells with O(2)radical scavengers (e.g. PDTC) or with Ca(++)channel blockers (e.g. verapamil) had a modest effect on IL-1beta-induced COX-2 expression.	o(2)radical	28-39	interleukin 1 beta	Homo sapiens	134-142
11399097-9	2001	Pre-treatment of cells with O(2)radical scavengers (e.g. PDTC) or with Ca(++)channel blockers (e.g. verapamil) had a modest effect on IL-1beta-induced COX-2 expression.	prolinedithiocarbamate	57-61	interleukin 1 beta	Homo sapiens	134-142
11399097-9	2001	Pre-treatment of cells with O(2)radical scavengers (e.g. PDTC) or with Ca(++)channel blockers (e.g. verapamil) had a modest effect on IL-1beta-induced COX-2 expression.	Verapamil	100-109	interleukin 1 beta	Homo sapiens	134-142
11278956-5	2001	PPARgamma activators, troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), inhibited IL-1beta-induced PDGFalphaR expression and suppressed PDGF-induced proliferation activity of VSMCs.	Troglitazone	22-34	interleukin 1 beta	Homo sapiens	91-99
11278956-5	2001	PPARgamma activators, troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), inhibited IL-1beta-induced PDGFalphaR expression and suppressed PDGF-induced proliferation activity of VSMCs.	15-deoxy-delta	39-53	interleukin 1 beta	Homo sapiens	91-99
11278956-5	2001	PPARgamma activators, troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), inhibited IL-1beta-induced PDGFalphaR expression and suppressed PDGF-induced proliferation activity of VSMCs.	prostaglandin j	61-76	interleukin 1 beta	Homo sapiens	91-99
11290798-0	2001	N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes.	Acetylglucosamine	0-19	interleukin 1 beta	Homo sapiens	29-38
11290798-4	2001	It is shown that both glucosamine and N-acetylglucosamine inhibit IL-1beta- and TNF-alpha-induced NO production in normal human articular chondrocytes.	Glucosamine	22-33	interleukin 1 beta	Homo sapiens	66-74
11290798-4	2001	It is shown that both glucosamine and N-acetylglucosamine inhibit IL-1beta- and TNF-alpha-induced NO production in normal human articular chondrocytes.	Acetylglucosamine	38-57	interleukin 1 beta	Homo sapiens	66-74
11290798-8	2001	In addition, N-acetylglucosamine also suppresses the production of IL-1beta-induced cyclooxygenase-2 and IL-6.	Acetylglucosamine	13-32	interleukin 1 beta	Homo sapiens	67-75
11290798-10	2001	N-acetylglucosamine-mediated inhibition of the IL-1beta response of human chondrocytes was not associated with the decreased inhibition of the mitogen-activated protein kinases c-Jun N-terminal kinase, extracellular signal-related kinase, and p38, nor with activation of the transcription factor NF-kappaB.	Acetylglucosamine	0-19	interleukin 1 beta	Homo sapiens	47-55
11318944-13	2001	Inhibition of nuclear factor-kappa B (NF-kappa B) activation either by sulindac or by the proteosome inhibitor (PSI) abrogated both IL-1 beta and glucose-mediated alteration in HA synthesis.	Sulindac	71-79	interleukin 1 beta	Homo sapiens	132-141
11306633-8	2001	Intrathecal administration of fluorocitrate (a glial metabolic inhibitor), TNF antagonist, and IL-1 antagonist each blocked gp120-induced increases in spinal IL-1 protein.	fluorocitrate	30-43	interleukin 1 beta	Homo sapiens	158-162
11306611-7	2001	Excitotoxins induced microglial proliferation and increased the release of NO metabolites and IL-1beta also in pure microglia cultures, and these responses were inhibited by minocycline.	Minocycline	174-185	interleukin 1 beta	Homo sapiens	94-102
11247871-0	2001	Down regulation of interleukin 1beta production in human osteoarthritic synovial tissue and cartilage cultures by aminoguanidine.	pimagedine	114-128	interleukin 1 beta	Homo sapiens	19-36
11238005-6	2001	Treatment of the animals with the ET receptor antagonist bosentan resulted in a substantial decrease in the concentrations of tumor necrosis factor-alpha, IL-4, IL-1beta, interferon-gamma, and ET-1 in bronchoalveolar lavage fluid.	Bosentan	57-65	interleukin 1 beta	Homo sapiens	161-169
11247871-7	2001	Hydrocortisone (5 microg/ml) also significantly decreased LPS stimulated IL1beta release in media of synovial tissue and cartilage cultures and NO in media of synovial cultures.	Hydrocortisone	0-14	interleukin 1 beta	Homo sapiens	73-80
11108714-11	2001	The viral replicative intermediate dsRNA stimulates beta-cell production of pro-IL-1beta, and following cleavage to its mature form by IFN-gamma-activated ICE, IL-1 then initiates beta-cell damage in a nitric oxide-dependent fashion.	Nitric Oxide	202-214	interleukin 1 beta	Homo sapiens	76-88
11400163-0	2001	Stimulation of hyaluronan synthesis by interleukin-1beta involves activation of protein kinase C betaII in fibroblasts from patients with Graves" ophthalmopathy.	Hyaluronic Acid	15-25	interleukin 1 beta	Homo sapiens	39-56
11400163-2	2001	Interleukin-1beta (IL-1beta) is known to stimulate hyaluronan synthesis in orbital fibroblasts.	Hyaluronic Acid	51-61	interleukin 1 beta	Homo sapiens	0-17
11400163-2	2001	Interleukin-1beta (IL-1beta) is known to stimulate hyaluronan synthesis in orbital fibroblasts.	Hyaluronic Acid	51-61	interleukin 1 beta	Homo sapiens	19-27
11400163-4	2001	IL-1beta-induced hyaluronan synthesis was significantly inhibited by pretreatment of the cells with two protein kinase C (PKC) inhibitors, chlerythrine chloride and H-7.	Hyaluronic Acid	17-27	interleukin 1 beta	Homo sapiens	0-8
11400163-4	2001	IL-1beta-induced hyaluronan synthesis was significantly inhibited by pretreatment of the cells with two protein kinase C (PKC) inhibitors, chlerythrine chloride and H-7.	chlerythrine chloride	139-160	interleukin 1 beta	Homo sapiens	0-8
11400163-4	2001	IL-1beta-induced hyaluronan synthesis was significantly inhibited by pretreatment of the cells with two protein kinase C (PKC) inhibitors, chlerythrine chloride and H-7.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	165-168	interleukin 1 beta	Homo sapiens	0-8
11400163-6	2001	IL-1beta- or PMA-stimulated hyaluronan synthesis was blocked by the protein synthesis inhibitor, cycloheximide.	Hyaluronic Acid	28-38	interleukin 1 beta	Homo sapiens	0-8
11400163-6	2001	IL-1beta- or PMA-stimulated hyaluronan synthesis was blocked by the protein synthesis inhibitor, cycloheximide.	Cycloheximide	97-110	interleukin 1 beta	Homo sapiens	0-8
11400163-7	2001	Moreover, the intracellular Ca(2+) concentration of the orbital fibroblasts was also involved in the IL-1beta induced transduction pathway, the effect being completely inhibited by BAPTA, an internal calcium chelator.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	181-186	interleukin 1 beta	Homo sapiens	101-109
11400163-7	2001	Moreover, the intracellular Ca(2+) concentration of the orbital fibroblasts was also involved in the IL-1beta induced transduction pathway, the effect being completely inhibited by BAPTA, an internal calcium chelator.	Calcium	200-207	interleukin 1 beta	Homo sapiens	101-109
11400163-9	2001	These results suggest that the Ca(2+)-dependent PKC signal transduction pathway plays an important role in the IL-1beta-induced hyaluronan synthesis.	Hyaluronic Acid	128-138	interleukin 1 beta	Homo sapiens	111-119
11400163-11	2001	These results indicate that cytosolic Ca(2+) and PKC betaII are involved in IL-1beta-induced hyaluronan synthesis in cultured orbital fibroblasts from patients with Graves" ophthalmopathy.	Hyaluronic Acid	93-103	interleukin 1 beta	Homo sapiens	76-84
11247871-9	2001	The NO donor, nitroprusside (10, 30, 100, and 300 microg/ml) stimulated IL1beta release in media of synovial tissue cultures in a dose dependent manner (p&lt;0.01 at 100 microg/ml).	Nitroprusside	14-27	interleukin 1 beta	Homo sapiens	72-79
11247871-1	2001	OBJECTIVE: To evaluate the effect of aminoguanidine (AG) on de novo interleukin 1beta (IL1beta), nitric oxide (NO), and interleukin 1 receptor antagonist (IL1ra) production by osteoarthritic human synovial tissue and articular cartilage cultures.	pimagedine	37-51	interleukin 1 beta	Homo sapiens	68-85
11327259-6	2001	In addition, treatment with 10 microg/ml doxycycline resulted in 2.2-fold upregulation of transforming growth factor (TGF-beta3) and a significant decrease of interleukin 1alpha (IL-1alpha), IL-1beta, and IL-6 mRNA.	Doxycycline	41-52	interleukin 1 beta	Homo sapiens	191-199
11256945-7	2001	LPS induced endogenous IL-1beta biosynthesis in a time-dependent manner; the administration of exogenous recombinant human interleukin 1 (rhIL-1) resulted in a dose-dependent activation of NF-kappaB.	lps	0-3	interleukin 1 beta	Homo sapiens	23-31
11241162-12	2001	The addition of dexamethasone to IL-1beta and TNFalpha significantly reduced the response of PBEF to these cytokines.	Dexamethasone	16-29	interleukin 1 beta	Homo sapiens	33-41
11327082-5	2001	IL-1beta and tumor necrosis factor alpha (TNFalpha), proinflammatory cytokines, induced IL-6 production in a time-dependent manner, and PGF2alpha synergistically enhanced IL-6 production induced by IL-1beta and TNFalpha.	Dinoprost	136-145	interleukin 1 beta	Homo sapiens	0-8
11327082-10	2001	From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation.	Dinoprost	105-114	interleukin 1 beta	Homo sapiens	159-167
11327082-5	2001	IL-1beta and tumor necrosis factor alpha (TNFalpha), proinflammatory cytokines, induced IL-6 production in a time-dependent manner, and PGF2alpha synergistically enhanced IL-6 production induced by IL-1beta and TNFalpha.	Dinoprost	136-145	interleukin 1 beta	Homo sapiens	198-206
11260714-4	2001	The major inducer of central Cox-2 upregulation is interleukin-1beta in the CNS, and as basal phospholipase A2 activity in the CNS does not change with peripheral inflammation, Cox-2 levels must regulate central prostanoid production.	Prostaglandins	212-222	interleukin 1 beta	Homo sapiens	51-68
11327082-6	2001	IL-6 mRNA was expressed in PGF2alpha-stimulated HGF, and PGF2alpha increased IL-6 mRNA levels induced by IL-1beta and TNFalpha.	Dinoprost	57-66	interleukin 1 beta	Homo sapiens	105-113
11254388-0	2001	Core and surface mutations affect folding kinetics, stability and cooperativity in IL-1 beta: does alteration in buried water play a role?	Water	120-125	interleukin 1 beta	Homo sapiens	83-92
11327082-10	2001	From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and TNFalpha-stimulated HGF, and that PGF2alpha-induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation.	Dinoprost	105-114	interleukin 1 beta	Homo sapiens	159-167
11260714-6	2001	Thus, preventing central prostanoid production by inhibiting the interleukin-1beta-mediated induction of Cox-2 in neurons or by inhibiting central Cox-2 activity reduces centrally generated inflammatory pain hypersensitivity.	Prostaglandins	25-35	interleukin 1 beta	Homo sapiens	65-82
11243706-5	2001	Epicatechin gallate, epigallocatechin and epigallocatechin gallate decreased the production of interleukin 1beta and enhanced the production of interleukin 10, but had no effect on the production of interleukin 6 or tumour necrosis factor-alpha.	epigallocatechin gallate	42-66	interleukin 1 beta	Homo sapiens	95-112
11246231-2	2001	To investigate whether the neuroprotectant N-acetyl-O-methyldopamine (NAMDA) downregulates genes associated with microglial activation, we measured gene expression of TNF-alpha, IL-1beta, inducible nitric oxide synthase (NOS2), and an associated cofactor synthesis gene, GTP cyclohydrolase I (GTPCH) in LPS-stimulated microglia cells in the presence or absence of NAMDA.	namda	70-75	interleukin 1 beta	Homo sapiens	178-186
11246231-3	2001	The temporal pattern of cytokine gene expression showed that LPS (0.2 microg/ml) increased TNF-alpha and IL-1beta gene expression at 1 and 3 h, which was repressed by cotreatment of NAMDA.	namda	182-187	interleukin 1 beta	Homo sapiens	105-113
11238627-5	2001	Likewise, SB203580 partially prevented the up-regulation of IL-1alpha, IL-1beta, IL-lRa, and TNF-alpha mRNA upon stimulation with LPS and TNF-alpha, as well as the release of bioactive TNF-alpha induced by LPS.	SB 203580	10-18	interleukin 1 beta	Homo sapiens	71-79
11243706-5	2001	Epicatechin gallate, epigallocatechin and epigallocatechin gallate decreased the production of interleukin 1beta and enhanced the production of interleukin 10, but had no effect on the production of interleukin 6 or tumour necrosis factor-alpha.	epicatechin gallate	0-19	interleukin 1 beta	Homo sapiens	95-112
11243706-5	2001	Epicatechin gallate, epigallocatechin and epigallocatechin gallate decreased the production of interleukin 1beta and enhanced the production of interleukin 10, but had no effect on the production of interleukin 6 or tumour necrosis factor-alpha.	gallocatechol	21-37	interleukin 1 beta	Homo sapiens	95-112
11282781-0	2001	Mechanisms of interleukin 1beta-induced human airway smooth muscle hyporesponsiveness to histamine.	Histamine	89-98	interleukin 1 beta	Homo sapiens	14-31
11171564-3	2001	A PKC-specific but isozyme-nonselective inhibitor, Ro-31-8220, and a cPKC selective inhibitor, Go-6976, caused significant attenuation of bufalin-induced interleukin-1beta (IL-1beta) gene expression, a mature monocytic marker, indicating that cPKC participates in the bufalin-induced cell differentiation.	Ro 31-8220	51-61	interleukin 1 beta	Homo sapiens	154-171
11171564-3	2001	A PKC-specific but isozyme-nonselective inhibitor, Ro-31-8220, and a cPKC selective inhibitor, Go-6976, caused significant attenuation of bufalin-induced interleukin-1beta (IL-1beta) gene expression, a mature monocytic marker, indicating that cPKC participates in the bufalin-induced cell differentiation.	Go 6976	95-102	interleukin 1 beta	Homo sapiens	154-171
11171564-3	2001	A PKC-specific but isozyme-nonselective inhibitor, Ro-31-8220, and a cPKC selective inhibitor, Go-6976, caused significant attenuation of bufalin-induced interleukin-1beta (IL-1beta) gene expression, a mature monocytic marker, indicating that cPKC participates in the bufalin-induced cell differentiation.	bufalin	138-145	interleukin 1 beta	Homo sapiens	154-171
11171564-3	2001	A PKC-specific but isozyme-nonselective inhibitor, Ro-31-8220, and a cPKC selective inhibitor, Go-6976, caused significant attenuation of bufalin-induced interleukin-1beta (IL-1beta) gene expression, a mature monocytic marker, indicating that cPKC participates in the bufalin-induced cell differentiation.	bufalin	138-145	interleukin 1 beta	Homo sapiens	173-181
11282781-2	2001	We have investigated the effect of IL-1beta on histamine H(1)-receptor (H(1)R)-mediated inositol phosphate (IP) accumulation in human airway smooth muscle cells (HASMC) and on histamine-induced contraction of human bronchial rings.	Histamine	47-56	interleukin 1 beta	Homo sapiens	35-43
11171589-5	2001	Interleukin (IL)-1beta (10 ng/ml) induces PGHS-2 expression and PGE(2) production in primary thyrocytes.	Dinoprostone	64-70	interleukin 1 beta	Homo sapiens	0-22
11171589-6	2001	The induction of PGHS-2 and PGE(2) synthesis by IL-1beta could be blocked by glucocorticoid treatment.	Prostaglandins E	28-31	interleukin 1 beta	Homo sapiens	48-56
11270638-0	2001	Interleukin-1beta-induced prostaglandin E2 production in human myometrial cells: role of a pertussis toxin-sensitive component.	Dinoprostone	26-42	interleukin 1 beta	Homo sapiens	0-17
11270638-4	2001	RESULTS: IL-1 increased PGE2 output during an 18-hr long incubation by 21.7-fold (n = 5 experiments).	Dinoprostone	24-28	interleukin 1 beta	Homo sapiens	9-13
11282781-3	2001	Stimulation of HASMC for 24 h with IL-1beta resulted in significant loss of histamine-induced IP formation, which was associated with a reduction of histamine- induced contraction of IL-1beta-treated human bronchial rings.	hasmc	15-20	interleukin 1 beta	Homo sapiens	35-43
11282781-3	2001	Stimulation of HASMC for 24 h with IL-1beta resulted in significant loss of histamine-induced IP formation, which was associated with a reduction of histamine- induced contraction of IL-1beta-treated human bronchial rings.	hasmc	15-20	interleukin 1 beta	Homo sapiens	183-191
11282781-3	2001	Stimulation of HASMC for 24 h with IL-1beta resulted in significant loss of histamine-induced IP formation, which was associated with a reduction of histamine- induced contraction of IL-1beta-treated human bronchial rings.	Histamine	76-85	interleukin 1 beta	Homo sapiens	35-43
11282781-2	2001	We have investigated the effect of IL-1beta on histamine H(1)-receptor (H(1)R)-mediated inositol phosphate (IP) accumulation in human airway smooth muscle cells (HASMC) and on histamine-induced contraction of human bronchial rings.	Inositol Phosphates	88-106	interleukin 1 beta	Homo sapiens	35-43
11263775-8	2001	Concomitant application of CTS abrogated the catabolic effects of IL-1beta on TMJ chondrocytes by inhibiting iNOS, COX-2, and MMP-1 mRNA production and NO, PGE2, and MMP-1 synthesis.	castanospermine	27-30	interleukin 1 beta	Homo sapiens	66-74
11282781-3	2001	Stimulation of HASMC for 24 h with IL-1beta resulted in significant loss of histamine-induced IP formation, which was associated with a reduction of histamine- induced contraction of IL-1beta-treated human bronchial rings.	Histamine	149-158	interleukin 1 beta	Homo sapiens	35-43
11282781-3	2001	Stimulation of HASMC for 24 h with IL-1beta resulted in significant loss of histamine-induced IP formation, which was associated with a reduction of histamine- induced contraction of IL-1beta-treated human bronchial rings.	Histamine	149-158	interleukin 1 beta	Homo sapiens	183-191
11282781-4	2001	An inhibitor of NF-kappaB activation, pyrrolidine dithiocarbamate, and a p38 MAPK inhibitor, blocked the IL-1beta-induced H(1)R desensitization, whereas anisomycin, an SAPK/JNK and p38 MAPK activator, mimicked the effect of IL-1beta.	pyrrolidine dithiocarbamic acid	38-65	interleukin 1 beta	Homo sapiens	105-113
11282781-5	2001	IL-1beta has been demonstrated to induce cox-2 expression and PGE(2) synthesis.	Dinoprostone	62-68	interleukin 1 beta	Homo sapiens	0-8
11282781-6	2001	In our study, indomethacin a cox antagonist, completely inhibited the effect of IL-1beta on H(1)R, whereas exogenously added PGE(2) was able to desensitize H(1)R.	Indomethacin	14-26	interleukin 1 beta	Homo sapiens	80-88
11282781-7	2001	Furthermore, H-89, a selective PKA inhibitor, antagonized the effect of IL-1beta.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	13-17	interleukin 1 beta	Homo sapiens	72-80
11282781-8	2001	Here, we have demonstrated that IL-1beta desensitizes H(1)R, which involves the activation of p38 MAPK and NF-kappaB, leading to the expression of cox-2 and the synthesis of PGE(2).	Prostaglandins E	174-177	interleukin 1 beta	Homo sapiens	32-40
11263775-8	2001	Concomitant application of CTS abrogated the catabolic effects of IL-1beta on TMJ chondrocytes by inhibiting iNOS, COX-2, and MMP-1 mRNA production and NO, PGE2, and MMP-1 synthesis.	Dinoprostone	156-160	interleukin 1 beta	Homo sapiens	66-74
11179516-7	2001	IL-1 beta-induced EGF receptor tyrosine phosphorylation started at 5 min and peaked at 10 min and remained elevated up to 40 min post IL-1 beta treatment.	Tyrosine	31-39	interleukin 1 beta	Homo sapiens	0-9
11230971-10	2001	In the presence of interleukin-1beta, AM augmented nitric oxide synthesis 2.7-fold in NMCs, but slightly in MCs.	Nitric Oxide	51-63	interleukin 1 beta	Homo sapiens	19-36
11259370-2	2001	We examined the effects of NO on the mRNA expression pattern in glomerular mesangial cells by using a low-stringency reverse transcriptase-polymerase chain reaction method and detected a cDNA fragment that was induced by interleukin 1b (IL-1b) and further up-regulated by the NO donor diethylenetriamine-nitric oxide (DETA-NO).	diethylenetriamine	285-303	interleukin 1 beta	Homo sapiens	221-235
11259370-2	2001	We examined the effects of NO on the mRNA expression pattern in glomerular mesangial cells by using a low-stringency reverse transcriptase-polymerase chain reaction method and detected a cDNA fragment that was induced by interleukin 1b (IL-1b) and further up-regulated by the NO donor diethylenetriamine-nitric oxide (DETA-NO).	diethylenetriamine	285-303	interleukin 1 beta	Homo sapiens	237-242
11259370-2	2001	We examined the effects of NO on the mRNA expression pattern in glomerular mesangial cells by using a low-stringency reverse transcriptase-polymerase chain reaction method and detected a cDNA fragment that was induced by interleukin 1b (IL-1b) and further up-regulated by the NO donor diethylenetriamine-nitric oxide (DETA-NO).	Nitric Oxide	304-316	interleukin 1 beta	Homo sapiens	221-235
11259370-2	2001	We examined the effects of NO on the mRNA expression pattern in glomerular mesangial cells by using a low-stringency reverse transcriptase-polymerase chain reaction method and detected a cDNA fragment that was induced by interleukin 1b (IL-1b) and further up-regulated by the NO donor diethylenetriamine-nitric oxide (DETA-NO).	Nitric Oxide	304-316	interleukin 1 beta	Homo sapiens	237-242
11259370-2	2001	We examined the effects of NO on the mRNA expression pattern in glomerular mesangial cells by using a low-stringency reverse transcriptase-polymerase chain reaction method and detected a cDNA fragment that was induced by interleukin 1b (IL-1b) and further up-regulated by the NO donor diethylenetriamine-nitric oxide (DETA-NO).	DETA-NO	318-325	interleukin 1 beta	Homo sapiens	221-235
11259370-2	2001	We examined the effects of NO on the mRNA expression pattern in glomerular mesangial cells by using a low-stringency reverse transcriptase-polymerase chain reaction method and detected a cDNA fragment that was induced by interleukin 1b (IL-1b) and further up-regulated by the NO donor diethylenetriamine-nitric oxide (DETA-NO).	DETA-NO	318-325	interleukin 1 beta	Homo sapiens	237-242
11179516-12	2001	EGF receptor kinase inhibitor PD153035 and AG1478 and MEK inhibitor PD98059 also blocked IL-1 beta induction of MMP-1 in cultured human keratinocytes.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	30-38	interleukin 1 beta	Homo sapiens	89-98
11179516-12	2001	EGF receptor kinase inhibitor PD153035 and AG1478 and MEK inhibitor PD98059 also blocked IL-1 beta induction of MMP-1 in cultured human keratinocytes.	RTKI cpd	43-49	interleukin 1 beta	Homo sapiens	89-98
11282563-1	2001	The role of endogenous IL-1beta in regulating spontaneous and Fas-triggered apoptosis of human PMN has been studied in relation to the activity of the IL-1beta-generating enzyme ICE (caspase-1), an enzyme also involved in the mechanism of cell death.	ammonium ferrous sulfate	62-65	interleukin 1 beta	Homo sapiens	23-31
11282563-6	2001	Inhibition of IL-1beta activity can increase Fas-induced apoptosis, whereas caspase-1 inhibitors are without significant effect.	ammonium ferrous sulfate	45-48	interleukin 1 beta	Homo sapiens	14-22
11282563-7	2001	It is hypothesized that in Fas-induced PMN apoptosis caspase-1 has a double role: it can protect from apoptosis through generation of protective IL-1beta, as in spontaneous apoptosis, and it can also exert pro-apoptotic activity which counterbalances the protective effect and allows accelerated apoptosis.	ammonium ferrous sulfate	27-30	interleukin 1 beta	Homo sapiens	145-153
11250126-0	2001	Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer"s disease.	Dinoprostone	58-74	interleukin 1 beta	Homo sapiens	0-17
11326829-8	2001	The amount of nitrite, TNF-alpha and IL-1 beta released from PBM of TB patients was inhibited by NG-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of NOS.	pbm	61-64	interleukin 1 beta	Homo sapiens	37-46
11326829-8	2001	The amount of nitrite, TNF-alpha and IL-1 beta released from PBM of TB patients was inhibited by NG-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of NOS.	omega-N-Methylarginine	97-121	interleukin 1 beta	Homo sapiens	37-46
11326829-8	2001	The amount of nitrite, TNF-alpha and IL-1 beta released from PBM of TB patients was inhibited by NG-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of NOS.	omega-N-Methylarginine	123-129	interleukin 1 beta	Homo sapiens	37-46
11179516-12	2001	EGF receptor kinase inhibitor PD153035 and AG1478 and MEK inhibitor PD98059 also blocked IL-1 beta induction of MMP-1 in cultured human keratinocytes.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	68-75	interleukin 1 beta	Homo sapiens	89-98
11179516-7	2001	IL-1 beta-induced EGF receptor tyrosine phosphorylation started at 5 min and peaked at 10 min and remained elevated up to 40 min post IL-1 beta treatment.	Tyrosine	31-39	interleukin 1 beta	Homo sapiens	134-143
11179516-8	2001	EGF receptor kinase inhibitor PD153035 and AG1478 inhibited IL-1 beta-induced EGF receptor tyrosine phosphorylation.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	30-38	interleukin 1 beta	Homo sapiens	60-69
11179516-8	2001	EGF receptor kinase inhibitor PD153035 and AG1478 inhibited IL-1 beta-induced EGF receptor tyrosine phosphorylation.	RTKI cpd	43-49	interleukin 1 beta	Homo sapiens	60-69
11179516-8	2001	EGF receptor kinase inhibitor PD153035 and AG1478 inhibited IL-1 beta-induced EGF receptor tyrosine phosphorylation.	Tyrosine	91-99	interleukin 1 beta	Homo sapiens	60-69
11179516-10	2001	We found that IL-1 beta-induced ERK phosphorylation, PD153035 and MEK inhibitor PD98059 blocked IL-1 beta-induced ERK activity.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	53-61	interleukin 1 beta	Homo sapiens	14-23
11179516-10	2001	We found that IL-1 beta-induced ERK phosphorylation, PD153035 and MEK inhibitor PD98059 blocked IL-1 beta-induced ERK activity.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	53-61	interleukin 1 beta	Homo sapiens	96-105
11179516-10	2001	We found that IL-1 beta-induced ERK phosphorylation, PD153035 and MEK inhibitor PD98059 blocked IL-1 beta-induced ERK activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	80-87	interleukin 1 beta	Homo sapiens	96-105
11266115-6	2001	Incubation with cytochalacin D, an actin polymerization inhibitor, prevents both microfilament reorganization and morphological changes, but has no effect on the IL-1beta production stimulated by fibrin fragment E. This data suggests that the IL-1beta production in the THP-1 cells do not require microfilament reorganization and integrin aggregation.	cytochalacin d	16-30	interleukin 1 beta	Homo sapiens	243-251
11288134-3	2001	It has been demonstrated that culture of human blood-derived LC-like cells with selected potent contact allergens such as 2,4-dinitrofluorobenzene (DNFB) stimulates selective phenotypic changes, including the up-regulation of interleukin 1 beta (IL-1 beta) mRNA expression, under conditions where skin irritants are without effect.	Dinitrofluorobenzene	122-146	interleukin 1 beta	Homo sapiens	226-244
11288134-3	2001	It has been demonstrated that culture of human blood-derived LC-like cells with selected potent contact allergens such as 2,4-dinitrofluorobenzene (DNFB) stimulates selective phenotypic changes, including the up-regulation of interleukin 1 beta (IL-1 beta) mRNA expression, under conditions where skin irritants are without effect.	Dinitrofluorobenzene	122-146	interleukin 1 beta	Homo sapiens	246-255
11288134-3	2001	It has been demonstrated that culture of human blood-derived LC-like cells with selected potent contact allergens such as 2,4-dinitrofluorobenzene (DNFB) stimulates selective phenotypic changes, including the up-regulation of interleukin 1 beta (IL-1 beta) mRNA expression, under conditions where skin irritants are without effect.	Dinitrofluorobenzene	148-152	interleukin 1 beta	Homo sapiens	226-244
11288134-3	2001	It has been demonstrated that culture of human blood-derived LC-like cells with selected potent contact allergens such as 2,4-dinitrofluorobenzene (DNFB) stimulates selective phenotypic changes, including the up-regulation of interleukin 1 beta (IL-1 beta) mRNA expression, under conditions where skin irritants are without effect.	Dinitrofluorobenzene	148-152	interleukin 1 beta	Homo sapiens	246-255
11288134-4	2001	However, in our own previous investigations, we have observed that there appear to be differences between blood donors with respect to the responsiveness of DCs to DNFB-induced changes in IL-1 beta expression, differences that could compromise the utility of this approach as a screening method for contact allergens.	Dinitrofluorobenzene	164-168	interleukin 1 beta	Homo sapiens	188-197
11288134-7	2001	Treatment of DCs isolated from donors with a responder phenotype to DNFB with PPD or CMIT resulted also in up-regulation of IL-1 beta mRNA expression, although such changes were always comparatively modest, generally resulting in a twofold induction compared with vehicle-treated controls.	Dinitrofluorobenzene	68-72	interleukin 1 beta	Homo sapiens	124-133
11288134-10	2001	The temporal stability of the responder/non-responder DC phenotype was confirmed, with stable phenotypes with respect to DNFB-induced changes in IL-1 beta mRNA expression observed over a period of some 18 months.	Dinitrofluorobenzene	121-125	interleukin 1 beta	Homo sapiens	145-154
11181934-3	2001	Buthionine sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione (GSH) biosynthesis, induced intracellular reactive oxygen species (ROS) and the release of interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha.	Buthionine Sulfoximine	0-22	interleukin 1 beta	Homo sapiens	219-236
11181934-3	2001	Buthionine sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione (GSH) biosynthesis, induced intracellular reactive oxygen species (ROS) and the release of interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha.	Buthionine Sulfoximine	0-22	interleukin 1 beta	Homo sapiens	238-246
11181934-3	2001	Buthionine sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione (GSH) biosynthesis, induced intracellular reactive oxygen species (ROS) and the release of interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha.	Reactive Oxygen Species	170-193	interleukin 1 beta	Homo sapiens	219-236
11181934-3	2001	Buthionine sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione (GSH) biosynthesis, induced intracellular reactive oxygen species (ROS) and the release of interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha.	Reactive Oxygen Species	170-193	interleukin 1 beta	Homo sapiens	238-246
11285373-8	2001	CONCLUSION: DEX may suppress the production of inflammatory cytokines, such as IL-6 and IL-1beta, but it neither prevents the translocation of NF-kappaB to the nucleus nor induces the synthesis of IkappaB-alpha protein in FLSs stimulated by TNF-alpha.	Dexamethasone	12-15	interleukin 1 beta	Homo sapiens	88-96
12536608-0	2001	[Effects of nao-yi-an on expressions of nerve growth factor and interleukin-1 beta following injury induced by hemoglobin in cultured hippocampal neurons].	nao-yi-an	12-21	interleukin 1 beta	Homo sapiens	64-82
11050099-0	2001	Recombinant human interleukins IL-1alpha, IL-1beta, IL-4, IL-6, and IL-7 show different and specific calcium-independent carbohydrate-binding properties.	Calcium	101-108	interleukin 1 beta	Homo sapiens	42-50
12536608-1	2001	OBJECTIVE: To investigate the effects of Nao-yi-an (NYA) on protecting the cultured hippocampal neurons against the injury induced by hemoglobin (Hb) and modulating the expressions of nerve growth factor (NGF) and interleukin-1 beta (IL-1 beta) following Hb injury.	nao-yi-an	41-50	interleukin 1 beta	Homo sapiens	214-232
12536608-1	2001	OBJECTIVE: To investigate the effects of Nao-yi-an (NYA) on protecting the cultured hippocampal neurons against the injury induced by hemoglobin (Hb) and modulating the expressions of nerve growth factor (NGF) and interleukin-1 beta (IL-1 beta) following Hb injury.	nao-yi-an	41-50	interleukin 1 beta	Homo sapiens	234-243
11050099-0	2001	Recombinant human interleukins IL-1alpha, IL-1beta, IL-4, IL-6, and IL-7 show different and specific calcium-independent carbohydrate-binding properties.	Carbohydrates	121-133	interleukin 1 beta	Homo sapiens	42-50
11223159-3	2001	Treatment of human U-251 MG astroglial cells with glatiramer acetate blocks IL-1beta-induced RANTES chemokine production in a dose- and time-dependent manner.	Glatiramer Acetate	50-68	interleukin 1 beta	Homo sapiens	76-84
11223159-9	2001	Our results suggest that glatiramer acetate may inhibit IL-1beta-stimulated RANTES expression in human glial cells by blocking NF-kappaB activation, thus identifying part of the molecular basis for its anti-inflammatory and immunosuppressive effects in demyelinating diseases.	Glatiramer Acetate	25-43	interleukin 1 beta	Homo sapiens	56-64
11160273-4	2001	IL-10 production was abrogated by the p38 inhibitor SB203580, but rather enhanced by the MAP/extracellular signal-related kinase kinase-I-specific inhibitor PD98059, whereas IL-1beta was only partially abrogated by SB203580 and PD98059.	SB 203580	215-223	interleukin 1 beta	Homo sapiens	174-182
11233994-1	2001	In the hope of identifying agents of therapeutic value in glomerulonephritis from Chinese herbs, we found that methanolic extracts of Polygonum hypoleucum Ohwi (P. hypoleucum Ohwi) inhibit human mesangial cells proliferation activated with interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) previously.	methanolic	111-121	interleukin 1 beta	Homo sapiens	240-257
11056157-0	2001	ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	26-48
11056157-8	2001	In evaluating the signaling components involved in the ATP effect, we identified that the protein-tyrosine kinase inhibitor, AG126, produced a profound inhibition of both ICE activation as well as release of IL-1beta/IL-18.	Adenosine Triphosphate	55-58	interleukin 1 beta	Homo sapiens	208-216
11056157-8	2001	In evaluating the signaling components involved in the ATP effect, we identified that the protein-tyrosine kinase inhibitor, AG126, produced a profound inhibition of both ICE activation as well as release of IL-1beta/IL-18.	AG 127	125-130	interleukin 1 beta	Homo sapiens	208-216
11056157-9	2001	Taken together, these results suggest that, although synthesis of IL-1beta and IL-18 differ, ATP-mediated release of both cytokines requires a priming step but not proteolytically functional caspase-1.	Adenosine Triphosphate	93-96	interleukin 1 beta	Homo sapiens	66-74
11161456-0	2001	Chemioxyexcitation (delta pO2/ROS)-dependent release of IL-1 beta, IL-6 and TNF-alpha: evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium.	Reactive Oxygen Species	30-33	interleukin 1 beta	Homo sapiens	56-65
11161461-0	2001	Interleukin 1 beta (IL-1 beta) action in porcine thyroid cells involves the ceramide signalling pathway.	Ceramides	76-84	interleukin 1 beta	Homo sapiens	0-18
11161461-0	2001	Interleukin 1 beta (IL-1 beta) action in porcine thyroid cells involves the ceramide signalling pathway.	Ceramides	76-84	interleukin 1 beta	Homo sapiens	20-29
11161461-3	2001	In this report we show that IL-1beta induces ceramide formation and sphingomyelin degradation in porcine thyroid cells via the activation of a neutral sphingomyelinase.	Ceramides	45-53	interleukin 1 beta	Homo sapiens	28-36
11161461-3	2001	In this report we show that IL-1beta induces ceramide formation and sphingomyelin degradation in porcine thyroid cells via the activation of a neutral sphingomyelinase.	Sphingomyelins	68-81	interleukin 1 beta	Homo sapiens	28-36
11264769-10	2001	NG-monomethyl-L-arginine inhibited the production of nitrite as well as IL-1beta and TNF-alpha in TB patients.	omega-N-Methylarginine	0-24	interleukin 1 beta	Homo sapiens	72-80
11264769-11	2001	The mRNA expression for IL-1beta and TNF-alpha was upregulated in TB patients and was depressed by L-NMMA.	omega-N-Methylarginine	99-105	interleukin 1 beta	Homo sapiens	24-32
11264769-13	2001	An inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis.	pyrrolidine dithiocarbamic acid	30-57	interleukin 1 beta	Homo sapiens	69-77
11233994-1	2001	In the hope of identifying agents of therapeutic value in glomerulonephritis from Chinese herbs, we found that methanolic extracts of Polygonum hypoleucum Ohwi (P. hypoleucum Ohwi) inhibit human mesangial cells proliferation activated with interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) previously.	methanolic	111-121	interleukin 1 beta	Homo sapiens	259-267
11272206-0	2001	Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis.	Imidazolines	0-11	interleukin 1 beta	Homo sapiens	38-55
11223651-1	2001	The in vitro effect of ibuprofen (IB) on the production of the proinflammatory cytokines interleukin (IL) 1beta, IL-6, and tumor necrosis factor alpha (TNF-alpha) and the anti-inflammatory cytokine IL-10 by cord blood mononuclear cells from preterm newborns was compared to that of peripheral blood mononuclear cells of adults.	Ibuprofen	23-32	interleukin 1 beta	Homo sapiens	89-111
11223651-1	2001	The in vitro effect of ibuprofen (IB) on the production of the proinflammatory cytokines interleukin (IL) 1beta, IL-6, and tumor necrosis factor alpha (TNF-alpha) and the anti-inflammatory cytokine IL-10 by cord blood mononuclear cells from preterm newborns was compared to that of peripheral blood mononuclear cells of adults.	Ibuprofen	34-36	interleukin 1 beta	Homo sapiens	89-111
11159726-11	2001	IL-1 beta (1 ng ml(-1)) attenuated early increases (up to 1 h) in cyclic AMP formation induced by salbutamol (1 microM), but not by forskolin (10 microM).	Cyclic AMP	66-76	interleukin 1 beta	Homo sapiens	0-9
11159726-11	2001	IL-1 beta (1 ng ml(-1)) attenuated early increases (up to 1 h) in cyclic AMP formation induced by salbutamol (1 microM), but not by forskolin (10 microM).	Albuterol	98-108	interleukin 1 beta	Homo sapiens	0-9
11159726-12	2001	The cyclo-oxygenase inhibitor, indomethacin (1 microM) prevented later increases (3 - 12 h) in IL-1 beta-stimulated cyclic AMP content, but did not prevent the attenuation by salbutamol of IL-1 beta-induced cytokine release.	Indomethacin	31-43	interleukin 1 beta	Homo sapiens	95-104
11159726-12	2001	The cyclo-oxygenase inhibitor, indomethacin (1 microM) prevented later increases (3 - 12 h) in IL-1 beta-stimulated cyclic AMP content, but did not prevent the attenuation by salbutamol of IL-1 beta-induced cytokine release.	Cyclic AMP	116-126	interleukin 1 beta	Homo sapiens	95-104
11159726-14	2001	We conclude in human ASM cells that activation of beta(2)-adrenoceptors and generation of cyclic AMP is negatively-linked to the release, elicited by IL-1 beta or TNF alpha, of eosinophil-activating cytokines such as GM-CSF, RANTES and eotaxin, but not IL-8.	Cyclic AMP	90-100	interleukin 1 beta	Homo sapiens	150-159
11251624-13	2001	Prepared solutions of various concentrations of IL-8, IL-1beta and sICAM-1 exposed to cigarette smoke demonstrated a dramatic exposure time-dependent decrease in the detectable amount of these mediators, an effect which was abrogated by GSH.	Glutathione	237-240	interleukin 1 beta	Homo sapiens	54-62
11272206-2	2001	We have now investigated the effects of imidazolines on interleukin (IL)-1beta-induced beta-cell apoptosis and the signal transduction pathways involved.	Imidazolines	40-52	interleukin 1 beta	Homo sapiens	56-78
11272206-3	2001	Inhibition of Ca2+ influx into beta-cells by D-600, a blocker of voltage-gated L-type Ca2+ channels, suppressed IL-1beta-induced apoptosis.	Gallopamil	45-50	interleukin 1 beta	Homo sapiens	112-120
11272206-5	2001	We also demonstrate that IL-1beta-mediated apoptosis correlates with expression of inducible nitric oxide synthase (iNOS) and the increase in intracellular production of nitric oxide.	Nitric Oxide	93-105	interleukin 1 beta	Homo sapiens	25-33
11272206-7	2001	One of the major findings in this study is that imidazoline compounds RX871024 and efaroxan, suggested as prototypes of a new generation of drugs against type 2 diabetes, can protect against IL-1beta-induced apoptosis in pancreatic beta-cells, possibly by their inhibition of the expression of iNOS, a key element in the IL-1beta-induced apoptotic pathway in pancreatic beta-cells.	Imidazolines	48-59	interleukin 1 beta	Homo sapiens	191-199
11272206-7	2001	One of the major findings in this study is that imidazoline compounds RX871024 and efaroxan, suggested as prototypes of a new generation of drugs against type 2 diabetes, can protect against IL-1beta-induced apoptosis in pancreatic beta-cells, possibly by their inhibition of the expression of iNOS, a key element in the IL-1beta-induced apoptotic pathway in pancreatic beta-cells.	Imidazolines	48-59	interleukin 1 beta	Homo sapiens	321-329
11272206-7	2001	One of the major findings in this study is that imidazoline compounds RX871024 and efaroxan, suggested as prototypes of a new generation of drugs against type 2 diabetes, can protect against IL-1beta-induced apoptosis in pancreatic beta-cells, possibly by their inhibition of the expression of iNOS, a key element in the IL-1beta-induced apoptotic pathway in pancreatic beta-cells.	efaroxan	83-91	interleukin 1 beta	Homo sapiens	191-199
11272206-7	2001	One of the major findings in this study is that imidazoline compounds RX871024 and efaroxan, suggested as prototypes of a new generation of drugs against type 2 diabetes, can protect against IL-1beta-induced apoptosis in pancreatic beta-cells, possibly by their inhibition of the expression of iNOS, a key element in the IL-1beta-induced apoptotic pathway in pancreatic beta-cells.	efaroxan	83-91	interleukin 1 beta	Homo sapiens	321-329
11159885-0	2001	Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells.	Disaccharides	0-13	interleukin 1 beta	Homo sapiens	72-81
11159047-5	2001	Incubation of precision-cut lung slices with a mixture of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and interferon (IFN)-gamma resulted in contraction of airways, which was accompanied by expression of cyclooxygenase (Cox)-2 and thromboxane release into the supernatant.	Thromboxanes	246-257	interleukin 1 beta	Homo sapiens	93-115
11159885-0	2001	Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells.	Heparin	27-34	interleukin 1 beta	Homo sapiens	72-81
11159885-0	2001	Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells.	Heparitin Sulfate	38-53	interleukin 1 beta	Homo sapiens	72-81
11322652-0	2001	Podophyllotoxin lignans enhance IL-1beta but suppress TNF-alpha mRNA expression in LPS-treated monocytes.	podophyllotoxin lignans	0-23	interleukin 1 beta	Homo sapiens	32-40
11289656-5	2001	However, there was no difference in spontaneous levels of soluble factors between OA and RA fibroblasts, though medium concentrations of IL-1beta-released VEGF, MMP-1, and PGE2, but not cytokines, in RA were slightly higher than those in OA.	Dinoprostone	172-176	interleukin 1 beta	Homo sapiens	137-145
11289656-6	2001	Ability to release soluble mediators was pronouncedly increased at 3 h to 9 h after stimulating fibroblasts with IL-1beta for 1 h. The proliferative response to IL-1beta in all fibroblasts was inhibited by dexamethasone and the NF-kappaB inhibitor hymenialdisine but not the cyclooxygenase 2 (COX-2) inhibitor NS-398.	Dexamethasone	206-219	interleukin 1 beta	Homo sapiens	113-121
11289656-6	2001	Ability to release soluble mediators was pronouncedly increased at 3 h to 9 h after stimulating fibroblasts with IL-1beta for 1 h. The proliferative response to IL-1beta in all fibroblasts was inhibited by dexamethasone and the NF-kappaB inhibitor hymenialdisine but not the cyclooxygenase 2 (COX-2) inhibitor NS-398.	Dexamethasone	206-219	interleukin 1 beta	Homo sapiens	161-169
11322652-4	2001	However, podophyllotoxin (0.1 microM) enhanced LPS-induced NF-kappa B activation and IL-1beta mRNA expression between 2 and 3-fold.	Podophyllotoxin	9-24	interleukin 1 beta	Homo sapiens	85-93
11289656-6	2001	Ability to release soluble mediators was pronouncedly increased at 3 h to 9 h after stimulating fibroblasts with IL-1beta for 1 h. The proliferative response to IL-1beta in all fibroblasts was inhibited by dexamethasone and the NF-kappaB inhibitor hymenialdisine but not the cyclooxygenase 2 (COX-2) inhibitor NS-398.	hymenialdisine	248-262	interleukin 1 beta	Homo sapiens	113-121
11289656-6	2001	Ability to release soluble mediators was pronouncedly increased at 3 h to 9 h after stimulating fibroblasts with IL-1beta for 1 h. The proliferative response to IL-1beta in all fibroblasts was inhibited by dexamethasone and the NF-kappaB inhibitor hymenialdisine but not the cyclooxygenase 2 (COX-2) inhibitor NS-398.	hymenialdisine	248-262	interleukin 1 beta	Homo sapiens	161-169
11344824-8	2001	RESULTS: Exposure to ethanol for 24 hours induced the expression of TNF-alpha and TGF-beta 1, secretion of IL-1 beta and TGF-beta 1 and decreased catalase activity.	Ethanol	21-28	interleukin 1 beta	Homo sapiens	107-116
11289656-6	2001	Ability to release soluble mediators was pronouncedly increased at 3 h to 9 h after stimulating fibroblasts with IL-1beta for 1 h. The proliferative response to IL-1beta in all fibroblasts was inhibited by dexamethasone and the NF-kappaB inhibitor hymenialdisine but not the cyclooxygenase 2 (COX-2) inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	310-316	interleukin 1 beta	Homo sapiens	113-121
11289656-6	2001	Ability to release soluble mediators was pronouncedly increased at 3 h to 9 h after stimulating fibroblasts with IL-1beta for 1 h. The proliferative response to IL-1beta in all fibroblasts was inhibited by dexamethasone and the NF-kappaB inhibitor hymenialdisine but not the cyclooxygenase 2 (COX-2) inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	310-316	interleukin 1 beta	Homo sapiens	161-169
11289656-7	2001	But PGE2 prevented proliferation of RA fibroblasts when added to medium up to 3 h after IL-1beta stimulation.	Dinoprostone	4-8	interleukin 1 beta	Homo sapiens	88-96
11289656-8	2001	Dexamethasone also inhibited the release of IL-6, IL-8, and PGE2 induced by IL-1beta in both OA and RA fibroblasts.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	76-84
11289656-8	2001	Dexamethasone also inhibited the release of IL-6, IL-8, and PGE2 induced by IL-1beta in both OA and RA fibroblasts.	Dinoprostone	60-64	interleukin 1 beta	Homo sapiens	76-84
11289656-9	2001	NS-398 exhibited an inhibition of IL-1beta-induced IL-6 production as well as PGE2 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	34-42
11289656-12	2001	CONCLUSION: The present results indicate that the activation of NF-kappaB plays an important role in the proliferative response to IL-1beta in human fibroblasts, and suggest that PGE2 acts as a modulator of cell proliferation in inflamed synovial tissue.	Dinoprostone	179-183	interleukin 1 beta	Homo sapiens	131-139
11344824-9	2001	Acetaldehyde markedly increased TNF-alpha and IL-8 expression, stimulated IL-1 beta and IL-8 secretion, increased lipid peroxidation damage and decreased catalase activity, while LPS exposure induced the expression of TNF-alpha, TGF-beta 1, IL-6 and IL-8, the secretion of TGF-beta 1, IL-1 beta, IL-6 and IL-8, and a decrease in catalase activity.	Acetaldehyde	0-12	interleukin 1 beta	Homo sapiens	74-83
11344824-9	2001	Acetaldehyde markedly increased TNF-alpha and IL-8 expression, stimulated IL-1 beta and IL-8 secretion, increased lipid peroxidation damage and decreased catalase activity, while LPS exposure induced the expression of TNF-alpha, TGF-beta 1, IL-6 and IL-8, the secretion of TGF-beta 1, IL-1 beta, IL-6 and IL-8, and a decrease in catalase activity.	Acetaldehyde	0-12	interleukin 1 beta	Homo sapiens	285-294
11244575-5	2001	Disruption of cytoskeletal organization with colchicine or cytochalasin B stimulated IL-1beta gene transcription and enhanced the cells" response to Col.	Colchicine	45-55	interleukin 1 beta	Homo sapiens	85-93
11160202-5	2001	On the other hand, ATP markedly and dose-dependently inhibited LPS- and soluble CD40 ligand-dependent production of IL-1alpha, IL-1beta, TNF-alpha, IL-6, and IL-12, whereas IL-1 receptor antagonist and IL-10 production was not affected.	Adenosine Triphosphate	19-22	interleukin 1 beta	Homo sapiens	127-135
11244575-5	2001	Disruption of cytoskeletal organization with colchicine or cytochalasin B stimulated IL-1beta gene transcription and enhanced the cells" response to Col.	Cytochalasin B	59-73	interleukin 1 beta	Homo sapiens	85-93
11330732-0	2001	Nitric oxide mediates inhibitory effect of interleukin-1beta on estrogen production in human granulosa-luteal cells.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	43-60
11330732-3	2001	RESULTS: IL-1beta induced a dose-dependent stimulation of NO production and inhibited the production of estradiol in a significant way in a dose-dependent manner.	Estradiol	104-113	interleukin 1 beta	Homo sapiens	9-17
11519483-2	2001	We hypothesized that IL1-beta, IL6, transforming growth factor (TGF-beta2 and platelet activating factor could increase macrophage QUIN production.	Quinolinic Acid	131-135	interleukin 1 beta	Homo sapiens	21-29
11169027-1	2001	BACKGROUND: In vitro stimulation of mononuclear cells (peripheral blood mononuclear cells; PBMCs) with an endotoxin (lipopolysaccharide; LPS) revealed elevated cell-associated levels of interleukin-1beta (IL-1beta) in end-stage renal disease (ESRD) patients on Cuprophan hemodialysis (HD), suggesting a defect in the process of IL-1beta"s release from activated cells.	cuprammonium cellulose	261-270	interleukin 1 beta	Homo sapiens	186-203
11169027-9	2001	RESULTS: The total production (cell-associated plus extracellular) of LPS-induced IL-1beta (proIL-1beta plus mIL-1beta) was similar in healthy controls (25.96 +/- 0.84 ng/2.5 x 10(6) PBMC), PD patients (29.53 +/- 1.31 ng/2.5 x 106 PBMC), and in Cuprophan-treated HD patients (23.28 +/- 1.24 ng/2.5 x 10(6) PBMC).	cuprammonium cellulose	245-254	interleukin 1 beta	Homo sapiens	82-90
11783344-1	2001	OBJECTIVE: To investigate the relationship between nitric oxide (NO) secreted by ovarian granular cell and interleukin-1 beta (IL-1 beta), and their functions in estrogen synthesis.	Nitric Oxide	51-63	interleukin 1 beta	Homo sapiens	107-125
11783344-1	2001	OBJECTIVE: To investigate the relationship between nitric oxide (NO) secreted by ovarian granular cell and interleukin-1 beta (IL-1 beta), and their functions in estrogen synthesis.	Nitric Oxide	51-63	interleukin 1 beta	Homo sapiens	127-136
11194936-8	2001	PGE2 synthesis by astrocytes and SK-N-SH cells was stimulated by interleukin-1beta.	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	65-82
11169130-6	2001	IL-1beta significantly and dose-dependently suppressed [3H]-uptake by EGCs.	Tritium	56-58	interleukin 1 beta	Homo sapiens	0-8
11169130-6	2001	IL-1beta significantly and dose-dependently suppressed [3H]-uptake by EGCs.	egcs	70-74	interleukin 1 beta	Homo sapiens	0-8
11167428-6	2001	After 48 h, propofol caused significant increases in IL-1beta (24%), IL-6 (23%) and TNF-alpha (4.8 times) levels, while midazolam caused significant decreases in IL-1beta (21%), IL-6 (21%) and TNF-alpha (19%).	Propofol	12-20	interleukin 1 beta	Homo sapiens	53-61
11836849-8	2001	Plasma interleukin 1 beta (IL 1 beta) was also higher in TMZ group notably 21 hours after the onset of symptoms (26.4 +/- 9.3 pg/ml vs. 16.2 +/- 2.4 pg/ml).	Trimetazidine	57-60	interleukin 1 beta	Homo sapiens	7-25
11836849-8	2001	Plasma interleukin 1 beta (IL 1 beta) was also higher in TMZ group notably 21 hours after the onset of symptoms (26.4 +/- 9.3 pg/ml vs. 16.2 +/- 2.4 pg/ml).	Trimetazidine	57-60	interleukin 1 beta	Homo sapiens	27-36
11727765-6	2001	Morphine pre-treatment potentiates the effects of LPS on endothelial cell viability, and on LPS induction of IL-1beta secretion from 1alpha, 25-dihydroxy-vitamin D3-treated HL-60 human leukemia cells.	25-dihydroxy-vitamin d3	141-164	interleukin 1 beta	Homo sapiens	109-117
11133489-4	2001	A high dose of ASA blocked IL-1 beta- and TNF-alpha-induced TNF-alpha and IL-8 expression, respectively.	Aspirin	15-18	interleukin 1 beta	Homo sapiens	27-36
11135729-7	2001	In addition, the concentration of both IL-1 beta and TNF alpha in the supernatant of lipopolysaccharide-stimulated MBC was significantly decreased (P &lt; 0.01) by perfluorohexane compared with controls without perfluorohexane.	perflexane	164-179	interleukin 1 beta	Homo sapiens	39-48
11135729-7	2001	In addition, the concentration of both IL-1 beta and TNF alpha in the supernatant of lipopolysaccharide-stimulated MBC was significantly decreased (P &lt; 0.01) by perfluorohexane compared with controls without perfluorohexane.	perflexane	211-226	interleukin 1 beta	Homo sapiens	39-48
11152649-4	2001	Cells stimulated with a combination of proinflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha each at 10 ng/ml) for 24 h released significant amounts of PGE2 (measured by radioimmunoassay) and GM-CSF (measured by enzyme-linked immunosorbent assay).	Dinoprostone	175-179	interleukin 1 beta	Homo sapiens	66-115
11167428-6	2001	After 48 h, propofol caused significant increases in IL-1beta (24%), IL-6 (23%) and TNF-alpha (4.8 times) levels, while midazolam caused significant decreases in IL-1beta (21%), IL-6 (21%) and TNF-alpha (19%).	Midazolam	120-129	interleukin 1 beta	Homo sapiens	162-170
11806247-8	2001	SB203580, a specific P38 MAPK inhibitor, blocked the ability of IL-1 beta to induce VEGF mRNA and promoter activity.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	64-73
11167428-9	2001	In conclusion, during 48 h of continuous infusion, propofol stimulated, while midazolam suppressed, the production of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, and both caused suppression of IL-8 production.	Propofol	51-59	interleukin 1 beta	Homo sapiens	149-157
11247319-5	2001	The effect of pamidronate was evaluated on intracellular cytokine profiles (IL-1, IL-6, TNF-alpha), disease activity and bone mass measurements.	Pamidronate	14-25	interleukin 1 beta	Homo sapiens	76-80
11296546-0	2001	Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.	nimesulide	90-100	interleukin 1 beta	Homo sapiens	27-45
11247319-7	2001	RESULTS: Spontaneous production of interleukin-1 beta by patient blood monocytes was lower in the pamidronate group and was associated with an increase in bone density of the spine after 12 months of therapy.	Pamidronate	98-109	interleukin 1 beta	Homo sapiens	35-53
11247319-10	2001	This rise is associated with a suppression of interleukin-1 beta production in monocytes of patients treated with pamidronate.	Pamidronate	114-125	interleukin 1 beta	Homo sapiens	46-64
11527154-5	2001	We hypothesized that disc cells might respond to shear stress and IL-1beta in a calcium signaling response.	Calcium	80-87	interleukin 1 beta	Homo sapiens	66-74
11247321-8	2001	IL-1 beta significantly decreased the proliferation rate of chondrocytes in co-cultures and slightly increased prostaglandin-E2 release.	Dinoprostone	111-127	interleukin 1 beta	Homo sapiens	0-9
11296546-2	2001	Nimesulide or NS-398 inhibited IL-1 beta-induced PGE2 production at all concentrations tested, and in addition they suppressed IL-1 beta-induced COX-2 mRNA expression and protein synthesis.	nimesulide	0-10	interleukin 1 beta	Homo sapiens	31-40
11296546-2	2001	Nimesulide or NS-398 inhibited IL-1 beta-induced PGE2 production at all concentrations tested, and in addition they suppressed IL-1 beta-induced COX-2 mRNA expression and protein synthesis.	nimesulide	0-10	interleukin 1 beta	Homo sapiens	127-136
11296546-2	2001	Nimesulide or NS-398 inhibited IL-1 beta-induced PGE2 production at all concentrations tested, and in addition they suppressed IL-1 beta-induced COX-2 mRNA expression and protein synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	14-20	interleukin 1 beta	Homo sapiens	31-40
11296546-2	2001	Nimesulide or NS-398 inhibited IL-1 beta-induced PGE2 production at all concentrations tested, and in addition they suppressed IL-1 beta-induced COX-2 mRNA expression and protein synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	14-20	interleukin 1 beta	Homo sapiens	127-136
11296546-2	2001	Nimesulide or NS-398 inhibited IL-1 beta-induced PGE2 production at all concentrations tested, and in addition they suppressed IL-1 beta-induced COX-2 mRNA expression and protein synthesis.	Dinoprostone	49-53	interleukin 1 beta	Homo sapiens	31-40
11296546-4	2001	Mechanistic studies revealed that the drug-induced inhibition of COX-2 expression and synthesis was not promoter-based, but may be associated with the blockade of IL-1 beta-dependent calcium flux and increased cellular calcium levels.	Calcium	183-190	interleukin 1 beta	Homo sapiens	163-172
11447767-0	2001	Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract.	sofalcone	21-30	interleukin 1 beta	Homo sapiens	66-84
11447767-0	2001	Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract.	Water	149-154	interleukin 1 beta	Homo sapiens	66-84
11447767-1	2001	We investigated the effect of sofalcone, a synthetic flavonoid derivative of sophoradin, on tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta production in human monocytes stimulated by Helicobacter pylori water extract.	sofalcone	30-39	interleukin 1 beta	Homo sapiens	130-153
11573136-4	2001	IL-6 has no effect on NIS functional activity, whereas IL-1beta suppresses iodide accumulation.	Iodides	75-81	interleukin 1 beta	Homo sapiens	55-63
11885921-3	2001	Heavy metals like CdCl2 can induce, or inhibit the synthesis and expression of the inflammatory cytokines IL-1beta, IL-4, IL-6, TNF-alpha, IFN-gamma and ICAM-1.	Cadmium Chloride	18-23	interleukin 1 beta	Homo sapiens	106-114
11172482-5	2001	The degradation and accumulation of 125I-LDL were significantly increased (P &lt; .02) in HuECs preincubated with IL-1 (100 U/mL) compared with control incubations without the cytokine or incubations containing gamma-IF, beta-IF, or TNF.	gamma-if	211-219	interleukin 1 beta	Homo sapiens	114-118
11793965-0	2001	Participation of COX, IL-1 beta and TNF alpha in formalin-induced inflammatory pain.	Formaldehyde	49-57	interleukin 1 beta	Homo sapiens	22-31
11007768-6	2000	Functional genomic analyses showed that soluble (s) IL-1RII, at picomolar concentrations, but not soluble TNF receptor:Fc, significantly inhibited IL-1beta-induced nitric oxide (NO) and/or prostaglandin E(2) production in chondrocytes, synovial and epithelial cells.	Nitric Oxide	164-176	interleukin 1 beta	Homo sapiens	147-155
12516391-1	2000	OBJECTIVE: To explore the effect of baicalin(BC) and dexamethasone(DXM) on interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha(TNF-alpha) in brain tissues of infectious brain edema.	Dexamethasone	53-66	interleukin 1 beta	Homo sapiens	95-104
12516391-1	2000	OBJECTIVE: To explore the effect of baicalin(BC) and dexamethasone(DXM) on interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha(TNF-alpha) in brain tissues of infectious brain edema.	Dexamethasone	67-70	interleukin 1 beta	Homo sapiens	75-93
12516391-1	2000	OBJECTIVE: To explore the effect of baicalin(BC) and dexamethasone(DXM) on interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha(TNF-alpha) in brain tissues of infectious brain edema.	Dexamethasone	67-70	interleukin 1 beta	Homo sapiens	95-104
12516391-7	2000	The water contents were positive linar correlated with IL-1 beta or TNF-alpha(P &gt; 0.05).	Water	4-9	interleukin 1 beta	Homo sapiens	55-64
12516391-8	2000	The water contents were positive linear correlated with IL-1 beta or TNF-alpha contents(r = 0.9381, 0.8349, P &lt; 0.01).	Water	4-9	interleukin 1 beta	Homo sapiens	56-65
12516391-12	2000	CONCLUSIONS: The results suggest that the protective effect of BC and DXM against infectious brain edema were similar, the mechanism may be associated with the reduction of TNF-alpha and IL-1 beta.	Dexamethasone	70-73	interleukin 1 beta	Homo sapiens	187-196
11178941-8	2001	After IL-1beta stimulation, NO degrees production was highly increased in the supernatants (45-fold increase in nitrite, 60-fold increase in nitrosothiols) as well as in cell lysates (35-fold increase in nitrosothiols).	Nitrites	112-119	interleukin 1 beta	Homo sapiens	6-14
11178941-8	2001	After IL-1beta stimulation, NO degrees production was highly increased in the supernatants (45-fold increase in nitrite, 60-fold increase in nitrosothiols) as well as in cell lysates (35-fold increase in nitrosothiols).	S-Nitrosothiols	141-154	interleukin 1 beta	Homo sapiens	6-14
11178941-8	2001	After IL-1beta stimulation, NO degrees production was highly increased in the supernatants (45-fold increase in nitrite, 60-fold increase in nitrosothiols) as well as in cell lysates (35-fold increase in nitrosothiols).	S-Nitrosothiols	204-217	interleukin 1 beta	Homo sapiens	6-14
11178941-12	2001	CONCLUSIONS: The IL-1beta stimulation increased nitrosothiol production by osteoarthritic chondrocytes.	S-Nitrosothiols	48-60	interleukin 1 beta	Homo sapiens	17-25
11694815-5	2001	Dexamethasone attenuated both IL-1beta- and TGF-beta1-stimulated expressions of MMP-3 and TIMP-3.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	30-38
12516391-1	2000	OBJECTIVE: To explore the effect of baicalin(BC) and dexamethasone(DXM) on interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha(TNF-alpha) in brain tissues of infectious brain edema.	baicalin	36-44	interleukin 1 beta	Homo sapiens	75-93
12516391-1	2000	OBJECTIVE: To explore the effect of baicalin(BC) and dexamethasone(DXM) on interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha(TNF-alpha) in brain tissues of infectious brain edema.	baicalin	36-44	interleukin 1 beta	Homo sapiens	95-104
12516391-1	2000	OBJECTIVE: To explore the effect of baicalin(BC) and dexamethasone(DXM) on interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha(TNF-alpha) in brain tissues of infectious brain edema.	Dexamethasone	53-66	interleukin 1 beta	Homo sapiens	75-93
11113771-10	2000	DU 145-conditioned media, but not the PrEC-conditioned media, contained SF/HGF-inducing activity, which was determined to include IL-1beta, bFGF, and PDGF by antibody-blocking experiments.	du	0-2	interleukin 1 beta	Homo sapiens	130-138
11104703-3	2000	Furthermore, IL-1beta selectively down-regulated the IL-6-induced tyrosine phosphorylation of STAT1 without affecting the level of STAT1 or tyrosine phosphorylation of STAT3.	Tyrosine	66-74	interleukin 1 beta	Homo sapiens	13-21
11104703-5	2000	However, pretreatment with the proteasome inhibitor MG132 under conditions that prevented the IL-1beta-dependent activation of the nuclear factor NF-kappaB also blocked the inhibitory effect of IL-1beta on IL-6-activated STAT1.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	52-57	interleukin 1 beta	Homo sapiens	94-102
11104703-5	2000	However, pretreatment with the proteasome inhibitor MG132 under conditions that prevented the IL-1beta-dependent activation of the nuclear factor NF-kappaB also blocked the inhibitory effect of IL-1beta on IL-6-activated STAT1.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	52-57	interleukin 1 beta	Homo sapiens	194-202
11104703-6	2000	In related experiments, the protein tyrosine phosphatase inhibitor Na(3)VO(4) also antagonized the inhibitory effect of IL-1beta on the activation of STAT1 by IL-6.	na(3)vo(4)	67-77	interleukin 1 beta	Homo sapiens	120-128
11172482-5	2001	The degradation and accumulation of 125I-LDL were significantly increased (P &lt; .02) in HuECs preincubated with IL-1 (100 U/mL) compared with control incubations without the cytokine or incubations containing gamma-IF, beta-IF, or TNF.	beta-if	221-228	interleukin 1 beta	Homo sapiens	114-118
11124973-0	2000	Nitric oxide modulation of interleukin-1[beta]-evoked intracellular Ca2+ release in human astrocytoma U-373 MG cells and brain striatal slices.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	27-45
11124973-4	2000	The nitric oxide (NO) donors diethylamine/NO complex (sodium salt) (0.3 and 1 mm) and spermine/NO (0.1 and 0.3 mm) mimicked the effect of IL-1beta on Ca(2+) release.	Nitric Oxide	4-16	interleukin 1 beta	Homo sapiens	138-146
11172482-7	2001	The increased rate of LDL catabolism by HuECs incubated with IL-1 was accompanied by a significant increase (P &lt; .05) in the rate of cholesteryl ester synthesis in the cells.	Cholesterol Esters	136-153	interleukin 1 beta	Homo sapiens	61-65
11124973-4	2000	The nitric oxide (NO) donors diethylamine/NO complex (sodium salt) (0.3 and 1 mm) and spermine/NO (0.1 and 0.3 mm) mimicked the effect of IL-1beta on Ca(2+) release.	diethylamine	29-41	interleukin 1 beta	Homo sapiens	138-146
11172482-13	2001	In summary, we now demonstrate that cytokines, specifically IL-1, may alter LDL metabolism by human vascular endothelial cells and alter endothelial cell cholesterol metabolism.	Cholesterol	154-165	interleukin 1 beta	Homo sapiens	60-64
11124973-5	2000	IL-1beta stimulated tissue cGMP concentration, and dibutyryl cGMP enhanced Ca(2+) release.	Cyclic GMP	27-31	interleukin 1 beta	Homo sapiens	0-8
11124973-6	2000	The guanyl cyclase inhibitors 1H-[1,2, 4]oxadiazole[4,3-a] quinoxalin-1-one (100 microm) and 6-[phenylamino]-5,8 quinolinedione (50 microm) counteracted Ca(2+) release induced by 2.5 but not 10 ng/ml IL-1beta.	1h-[1,2, 4]oxadiazole[4,3-a] quinoxalin-1-one	30-75	interleukin 1 beta	Homo sapiens	200-208
11124973-6	2000	The guanyl cyclase inhibitors 1H-[1,2, 4]oxadiazole[4,3-a] quinoxalin-1-one (100 microm) and 6-[phenylamino]-5,8 quinolinedione (50 microm) counteracted Ca(2+) release induced by 2.5 but not 10 ng/ml IL-1beta.	6-anilino-5,8-quinolinedione	93-127	interleukin 1 beta	Homo sapiens	200-208
11076808-5	2000	Neutralizing antibodies to epidermal growth factor (EGF) and transforming growth factor-alpha or inhibition of the EGF receptor by tyrphostin AG-1478 or genistein inhibited IL-1beta-induced alveolar epithelial repair, indicating that IL-1beta enhances in vitro alveolar epithelial repair by an EGF- or transforming growth factor-alpha-dependent mechanism.	Tyrphostins	131-141	interleukin 1 beta	Homo sapiens	173-181
11124973-7	2000	Ruthenium red (50 microm) and, to a lesser extent, heparin (3 mg/ml) antagonized IL-1beta-induced Ca(2+) release, and both compounds administered together completely abolished this response.	Ruthenium Red	0-13	interleukin 1 beta	Homo sapiens	81-89
11124973-7	2000	Ruthenium red (50 microm) and, to a lesser extent, heparin (3 mg/ml) antagonized IL-1beta-induced Ca(2+) release, and both compounds administered together completely abolished this response.	Heparin	51-58	interleukin 1 beta	Homo sapiens	81-89
11124973-8	2000	Similar results were obtained in human astrocytoma cells in which IL-1beta elicited a delayed (30 min) increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) (402 +/- 71.2% of baseline), which was abolished by 1 mm l-NAME.	NG-Nitroarginine Methyl Ester	221-227	interleukin 1 beta	Homo sapiens	66-74
11124973-9	2000	These data indicate that the NO/cGMP-signaling pathway is part of the intracellular mechanism transducing IL-1beta-evoked Ca(2+) mobilization in glial and striatal cells and that the ryanodine and the inositol-(1,4,5)-trisphosphate-sensitive Ca(2+) stores are involved.	Cyclic GMP	32-36	interleukin 1 beta	Homo sapiens	106-114
11124973-9	2000	These data indicate that the NO/cGMP-signaling pathway is part of the intracellular mechanism transducing IL-1beta-evoked Ca(2+) mobilization in glial and striatal cells and that the ryanodine and the inositol-(1,4,5)-trisphosphate-sensitive Ca(2+) stores are involved.	Ryanodine	183-192	interleukin 1 beta	Homo sapiens	106-114
11124973-9	2000	These data indicate that the NO/cGMP-signaling pathway is part of the intracellular mechanism transducing IL-1beta-evoked Ca(2+) mobilization in glial and striatal cells and that the ryanodine and the inositol-(1,4,5)-trisphosphate-sensitive Ca(2+) stores are involved.	Inositol 1,4,5-Trisphosphate	201-231	interleukin 1 beta	Homo sapiens	106-114
11189028-3	2000	A difficulty, however, is that (1) IL-1beta is not expressed constitutively in mononuclear phagocytes, their presumed cell source upon stimulation by exogenous pyrogens, e.g. endotoxin, and (2) similarly, the isoform of the enzyme that selectively mediates the production and release of PGE2 by endotoxin-stimulated macrophages, COX-2, is also not constitutively expressed in these cells.	Dinoprostone	287-291	interleukin 1 beta	Homo sapiens	35-43
11078722-7	2000	PD-098059, specific inhibitor of p42/p44 MAPK pathway, counteracts the apoptotic effect of IL-1beta, whereas SB-203580, specific inhibitor of p38 stress-activated protein kinase (SAPK) pathway, is ineffective.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-9	interleukin 1 beta	Homo sapiens	91-99
11076808-5	2000	Neutralizing antibodies to epidermal growth factor (EGF) and transforming growth factor-alpha or inhibition of the EGF receptor by tyrphostin AG-1478 or genistein inhibited IL-1beta-induced alveolar epithelial repair, indicating that IL-1beta enhances in vitro alveolar epithelial repair by an EGF- or transforming growth factor-alpha-dependent mechanism.	Genistein	153-162	interleukin 1 beta	Homo sapiens	173-181
11076808-6	2000	Moreover, the mitogen-activated protein kinase pathway is involved in IL-1beta-induced alveolar epithelial repair because inhibition of extracellular signal-regulated kinase activation by PD-98059 inhibited IL-1beta-induced alveolar epithelial repair.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	188-196	interleukin 1 beta	Homo sapiens	70-78
11080076-4	2000	Concurrently, PTX pretreatment suppressed low-dose LPS-induced TNF-alpha production by more than 95% and IL-1beta production 39%, as measured by ELISA.	Pentoxifylline	14-17	interleukin 1 beta	Homo sapiens	105-113
11076808-6	2000	Moreover, the mitogen-activated protein kinase pathway is involved in IL-1beta-induced alveolar epithelial repair because inhibition of extracellular signal-regulated kinase activation by PD-98059 inhibited IL-1beta-induced alveolar epithelial repair.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	188-196	interleukin 1 beta	Homo sapiens	207-215
11175313-1	2000	Interleukin-1beta is a potent pro-inflammatory cytokine that has been shown to inhibit islet beta cell function as well as to activate Fas-mediated apoptosis in a nitric oxide-dependent manner.	Nitric Oxide	163-175	interleukin 1 beta	Homo sapiens	0-17
11112151-0	2000	Effect of endogenous and exogenous prostaglandin E(2) on interleukin-1 beta-induced cyclooxygenase-2 expression in human airway smooth-muscle cells.	Dinoprostone	35-53	interleukin 1 beta	Homo sapiens	57-75
11112151-1	2000	We studied the effect of endogenous and exogenous prostaglandin E(2) (PGE(2)), a metabolite of arachidonic acid through the cyclooxygenase (COX) pathway, on interleukin (IL)-1 beta-induced COX-2 expression, using primary cultures of human bronchial smooth-muscle cells (HBSMC).	Dinoprostone	50-68	interleukin 1 beta	Homo sapiens	157-180
11112151-2	2000	Treatment with exogenous PGE(2) resulted in enhanced expression of IL-1 beta-induced COX-2 protein and messenger RNA (mRNA) as compared with the effect of the cytokine per se.	Prostaglandins E	25-28	interleukin 1 beta	Homo sapiens	67-76
11112151-3	2000	Inhibition of PGE(2) production with a nonselective COX inhibitor (flurbiprofen, 10 microM) resulted in a significant reduction in IL-1 beta- induced COX-2 expression, supporting a role of endogenous COX metabolites in the modulation of COX-2 expression.	Dinoprostone	14-20	interleukin 1 beta	Homo sapiens	131-140
11112151-3	2000	Inhibition of PGE(2) production with a nonselective COX inhibitor (flurbiprofen, 10 microM) resulted in a significant reduction in IL-1 beta- induced COX-2 expression, supporting a role of endogenous COX metabolites in the modulation of COX-2 expression.	Flurbiprofen	67-79	interleukin 1 beta	Homo sapiens	131-140
11112151-6	2000	PGE(2) increased adenylate cyclase activity in a concentration dependent manner, and forskolin, a direct activator of adenylate cyclase, caused a marked increase in IL-1 beta-dependent COX-2, suggesting the existence of a causal relationship between the two events.	Prostaglandins E	0-3	interleukin 1 beta	Homo sapiens	165-174
11112151-6	2000	PGE(2) increased adenylate cyclase activity in a concentration dependent manner, and forskolin, a direct activator of adenylate cyclase, caused a marked increase in IL-1 beta-dependent COX-2, suggesting the existence of a causal relationship between the two events.	Colforsin	85-94	interleukin 1 beta	Homo sapiens	165-174
11090106-8	2000	Similarly, lipopolysaccharide induced interleukin-1 beta release from these cells was inhibited by NCX-1015 with higher potency than prednisolone.	Prednisolone	133-145	interleukin 1 beta	Homo sapiens	38-56
11099464-8	2000	Finally, stimulation of LPS-matured cells with ATP triggered release of IL-1 beta and TNF-alpha.	Adenosine Triphosphate	47-50	interleukin 1 beta	Homo sapiens	72-81
11175313-6	2000	Adenoviral gene transfer of human IGF-I prevented IL-1beta-mediated nitric oxide production from human islets in vitro as well as the suppression of beta cell function as determined by glucose-stimulated insulin production.	Nitric Oxide	68-80	interleukin 1 beta	Homo sapiens	50-58
11201045-9	2000	AH-23848B, an EP4 antagonist, antagonized the inhibitory effect of IL-1beta-elicited ICAM-1 expression by PGE2.	AH 23848	0-9	interleukin 1 beta	Homo sapiens	67-75
11083814-5	2000	Furthermore, PMN stimulated by OMV in the presence of IFN-gamma demonstrated an enhanced capacity to release TNF-alpha, IL-1beta, IL-8, and MIP-1beta compared to stimulation with OMV alone.	1-ethylcyclopentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate	31-34	interleukin 1 beta	Homo sapiens	120-128
11201045-2	2000	We have previously demonstrated that PGE2 down-regulates intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1beta (IL-1beta)-stimulated human gingival fibroblasts (HGF).	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	114-131
11201045-2	2000	We have previously demonstrated that PGE2 down-regulates intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1beta (IL-1beta)-stimulated human gingival fibroblasts (HGF).	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	133-141
11201045-3	2000	In the present study, we investigated which COX was involved in down-regulation of ICAM-1 expression by PGE2 in IL-1beta-stimulated HGF and which subtypes of EP receptors modulated the ICAM-1 expression.	Dinoprostone	104-108	interleukin 1 beta	Homo sapiens	112-120
11201045-0	2000	Cyclooxygenase-2-dependent prostaglandin E2 down-regulates intercellular adhesion molecule-1 expression via EP2/EP4 receptors in interleukin-1beta-stimulated human gingival fibroblasts.	Dinoprostone	27-43	interleukin 1 beta	Homo sapiens	129-146
11201045-9	2000	AH-23848B, an EP4 antagonist, antagonized the inhibitory effect of IL-1beta-elicited ICAM-1 expression by PGE2.	Dinoprostone	106-110	interleukin 1 beta	Homo sapiens	67-75
11201045-4	2000	NS-398, a specific COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated HGF, as did indomethacin, a COX-1/COX-2 inhibitor.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	76-84
11201045-4	2000	NS-398, a specific COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated HGF, as did indomethacin, a COX-1/COX-2 inhibitor.	Dinoprostone	57-61	interleukin 1 beta	Homo sapiens	76-84
11201045-11	2000	Analysis of these data suggests that COX-2-derived PGE2 down-regulates ICAM-1 expression via EP2/EP4 receptors in IL-1beta-stimulated HGF.	Dinoprostone	51-55	interleukin 1 beta	Homo sapiens	114-122
11201045-6	2000	NS-398 and indomethacin enhanced ICAM-1 expression in IL-1beta-challenged HGF.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	54-62
11093788-2	2000	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression.	Genistein	28-37	interleukin 1 beta	Homo sapiens	132-140
11201045-6	2000	NS-398 and indomethacin enhanced ICAM-1 expression in IL-1beta-challenged HGF.	Indomethacin	11-23	interleukin 1 beta	Homo sapiens	54-62
11201045-8	2000	PGE2, 11-deoxy-PGE1 (a selective EP2/EP4 agonist), and Butaprost (a selective EP2 agonist) attenuated IL-1beta-elicited ICAM-1 expression, although Butaprost was less potent than PGE2 and 11-deoxy-PGE1.	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	102-110
11201045-8	2000	PGE2, 11-deoxy-PGE1 (a selective EP2/EP4 agonist), and Butaprost (a selective EP2 agonist) attenuated IL-1beta-elicited ICAM-1 expression, although Butaprost was less potent than PGE2 and 11-deoxy-PGE1.	11-deoxyprostaglandin E1	6-19	interleukin 1 beta	Homo sapiens	102-110
11201045-8	2000	PGE2, 11-deoxy-PGE1 (a selective EP2/EP4 agonist), and Butaprost (a selective EP2 agonist) attenuated IL-1beta-elicited ICAM-1 expression, although Butaprost was less potent than PGE2 and 11-deoxy-PGE1.	butaprost	55-64	interleukin 1 beta	Homo sapiens	102-110
11093788-4	2000	PKC inhibitors (staurosporine, Ro 31-8220, calphostin C, or Go 6976) also inhibited IL-1beta-induced response.	Staurosporine	16-29	interleukin 1 beta	Homo sapiens	84-92
11093788-8	2000	NF-kappaB DNA-protein binding and ICAM-1 promoter activity were enhanced by IL-1beta and these effects were inhibited by tyrphostin 23, but not by PD 98059 or SB 203580.	Tyrphostins	121-131	interleukin 1 beta	Homo sapiens	76-84
11093788-2	2000	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression.	Tyrphostins	41-51	interleukin 1 beta	Homo sapiens	132-140
11093788-12	2000	Taken together, IL-1beta activates phosphatidylcholine-specific phospholipase C and induces activation of PKCalpha and protein tyrosine kinase, resulting in the stimulation of NIK, IKK2, and NF-kappaB in the ICAM-1 promoter, then initiation of ICAM-1 expression.	Phosphatidylcholines	35-54	interleukin 1 beta	Homo sapiens	16-24
11093788-2	2000	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression.	Phosphatidylcholines	59-78	interleukin 1 beta	Homo sapiens	132-140
11093788-2	2000	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression.	tricyclodecane-9-yl-xanthogenate	115-119	interleukin 1 beta	Homo sapiens	132-140
11119262-5	2000	Furthermore, 10(-6) M enprostil suppressed IL-8 production in HT-29 cells, SW620 and CaCo2 stimulated with interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS), but did not suppress this response when cells were stimulated with tumour necrosis factor (TNF)-alpha.	caco2	85-90	interleukin 1 beta	Homo sapiens	107-125
11119262-5	2000	Furthermore, 10(-6) M enprostil suppressed IL-8 production in HT-29 cells, SW620 and CaCo2 stimulated with interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS), but did not suppress this response when cells were stimulated with tumour necrosis factor (TNF)-alpha.	Enprostil	22-31	interleukin 1 beta	Homo sapiens	107-125
11119262-5	2000	Furthermore, 10(-6) M enprostil suppressed IL-8 production in HT-29 cells, SW620 and CaCo2 stimulated with interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS), but did not suppress this response when cells were stimulated with tumour necrosis factor (TNF)-alpha.	caco2	85-90	interleukin 1 beta	Homo sapiens	127-136
11119262-5	2000	Furthermore, 10(-6) M enprostil suppressed IL-8 production in HT-29 cells, SW620 and CaCo2 stimulated with interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS), but did not suppress this response when cells were stimulated with tumour necrosis factor (TNF)-alpha.	Enprostil	22-31	interleukin 1 beta	Homo sapiens	127-136
11193379-7	2000	A beta-adrenoceptor agonists (beta-agonist), procaterol, clenbuterol, fenoterol and terbutaline suppressed the production of TNF- and IL-1 beta.	Procaterol	45-55	interleukin 1 beta	Homo sapiens	134-143
11193379-7	2000	A beta-adrenoceptor agonists (beta-agonist), procaterol, clenbuterol, fenoterol and terbutaline suppressed the production of TNF- and IL-1 beta.	Clenbuterol	57-68	interleukin 1 beta	Homo sapiens	134-143
11193379-7	2000	A beta-adrenoceptor agonists (beta-agonist), procaterol, clenbuterol, fenoterol and terbutaline suppressed the production of TNF- and IL-1 beta.	Fenoterol	70-79	interleukin 1 beta	Homo sapiens	134-143
11193379-7	2000	A beta-adrenoceptor agonists (beta-agonist), procaterol, clenbuterol, fenoterol and terbutaline suppressed the production of TNF- and IL-1 beta.	Terbutaline	84-95	interleukin 1 beta	Homo sapiens	134-143
11193379-10	2000	The inhibition of the production of TNF-alpha and IL-1 beta by procaterol was additively potentiated with theophylline.	Procaterol	63-73	interleukin 1 beta	Homo sapiens	50-59
11053030-4	2000	The p38 inhibitor SB-203580 (3 microM) decreased IL-1 beta-induced COX-2 by 70 +/- 7% (P &lt; 0.01).	SB 203580	18-27	interleukin 1 beta	Homo sapiens	49-58
11052988-7	2000	We showed that butyrate selectively enhanced the protein production and mRNA expression of stromelysin-1 in tumor necrosis factor-alpha- or interleukin-1beta-stimulated mesenchymal cells.	Butyrates	15-23	interleukin 1 beta	Homo sapiens	140-157
11053033-3	2000	Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta.	triptolide	0-10	interleukin 1 beta	Homo sapiens	248-257
11053030-5	2000	SB-203580 had no effect on PGE(2) release in control cells but caused a significant (70-80%) reduction in PGE(2) release in IL-1 beta-treated cells.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	124-133
11053030-5	2000	SB-203580 had no effect on PGE(2) release in control cells but caused a significant (70-80%) reduction in PGE(2) release in IL-1 beta-treated cells.	Prostaglandins E	106-109	interleukin 1 beta	Homo sapiens	124-133
11053030-6	2000	IL-1 beta increased the binding of nuclear proteins to the oligonucleotides encoding the consensus sequences for activator protein (AP)-1 and nuclear factor (NF)-kappa B, but SB-203580 did not affect this binding, suggesting that the mechanism of action of p38 was not through AP-1 or NF-kappa B activation.	Oligonucleotides	59-75	interleukin 1 beta	Homo sapiens	0-9
11053030-8	2000	IL-1 beta attenuated isoproterenol-induced decreases in HASM stiffness as measured by magnetic twisting cytometry, and SB-203580 abolished this effect.	Isoproterenol	21-34	interleukin 1 beta	Homo sapiens	0-9
11053030-9	2000	These results are consistent with the hypothesis that p38 is involved in the signal transduction pathway through which IL-1 beta induces COX-2 expression, PGE(2) release, and beta-adrenergic hyporesponsiveness.	Dinoprostone	155-160	interleukin 1 beta	Homo sapiens	119-128
11052920-5	2000	We investigated the effect of ciprofloxacin on tumour necrosis factor alpha- and IL-1beta-mediated activation of the transcription factors nuclear factor kappaB (NFkappaB), activator protein-1 (AP-1) and nuclear factor IL-6 (NF-IL-6) using an electrophoretic mobility shift assay, and the effect on expression of mRNA for IL-6 and IL-8 by reverse transcriptase-PCR in the EAhy926 endothelial cell line.	Ciprofloxacin	30-43	interleukin 1 beta	Homo sapiens	81-89
11052809-6	2000	Deletion analysis and co-transfection studies using consensus activator protein 1 (AP-1) oligonucleotides suggested that an AP-1 site present in the 5" end of the IL-1beta promoter was involved in the FN-induced response.	Oligonucleotides	89-105	interleukin 1 beta	Homo sapiens	163-171
11025451-0	2000	Induction of MRP1 and gamma-glutamylcysteine synthetase gene expression by interleukin 1beta is mediated by nitric oxide-related signalings in human colorectal cancer cells.	Nitric Oxide	108-120	interleukin 1 beta	Homo sapiens	75-92
11153595-3	2000	It was hypothesized that lipopolysaccharide (LPS)-induced IL-1beta secretion may be modulated by the intracellular thiol redox status of the cells.	Sulfhydryl Compounds	115-120	interleukin 1 beta	Homo sapiens	58-66
11153595-7	2000	In addition, treatment of cells with cycloheximide, an inhibitor of protein synthesis, inhibited the NAC-mediated IL-1beta release.	Cycloheximide	37-50	interleukin 1 beta	Homo sapiens	114-122
11246818-5	2000	Dexamethesone increased PAI-1 activity after incubation for 8 h (p &lt; 0.05) and enhanced the stimulation of IL-1beta after 8 h incubation.	dexamethesone	0-13	interleukin 1 beta	Homo sapiens	110-118
11246818-6	2000	However, after 24 and 48 h, dexamethasone significantly reduced the IL-1beta induced increase in PAI-1 activity by 24-52% (p &lt; 0.05), accordingly, PAI-1 mRNA expression was reduced 60%.	Dexamethasone	28-41	interleukin 1 beta	Homo sapiens	68-76
11025451-1	2000	Treatment of human colorectal cancer cells HT29 with interleukin 1beta (IL-1beta) induces expression of the multidrug resistance protein (MRP1) gene encoding the ATP-dependent glutathione S-conjugate export (GS-X) pump and the gamma-glutamylcysteine synthetase (gamma-GCSh) gene encoding heavy (catalytic) subunit of gamma-glutamylcysteine synthetase, the rate-limiting enzyme for the biosynthesis of glutathione (GSH).	Glutathione	176-187	interleukin 1 beta	Homo sapiens	53-70
11025451-1	2000	Treatment of human colorectal cancer cells HT29 with interleukin 1beta (IL-1beta) induces expression of the multidrug resistance protein (MRP1) gene encoding the ATP-dependent glutathione S-conjugate export (GS-X) pump and the gamma-glutamylcysteine synthetase (gamma-GCSh) gene encoding heavy (catalytic) subunit of gamma-glutamylcysteine synthetase, the rate-limiting enzyme for the biosynthesis of glutathione (GSH).	Glutathione	176-187	interleukin 1 beta	Homo sapiens	72-80
11025451-1	2000	Treatment of human colorectal cancer cells HT29 with interleukin 1beta (IL-1beta) induces expression of the multidrug resistance protein (MRP1) gene encoding the ATP-dependent glutathione S-conjugate export (GS-X) pump and the gamma-glutamylcysteine synthetase (gamma-GCSh) gene encoding heavy (catalytic) subunit of gamma-glutamylcysteine synthetase, the rate-limiting enzyme for the biosynthesis of glutathione (GSH).	Glutathione	414-417	interleukin 1 beta	Homo sapiens	53-70
11025451-1	2000	Treatment of human colorectal cancer cells HT29 with interleukin 1beta (IL-1beta) induces expression of the multidrug resistance protein (MRP1) gene encoding the ATP-dependent glutathione S-conjugate export (GS-X) pump and the gamma-glutamylcysteine synthetase (gamma-GCSh) gene encoding heavy (catalytic) subunit of gamma-glutamylcysteine synthetase, the rate-limiting enzyme for the biosynthesis of glutathione (GSH).	Glutathione	414-417	interleukin 1 beta	Homo sapiens	72-80
11025451-3	2000	These results suggest that IL-1beta-mediated MRP1 and gamma-GCSh induction involve nitric oxide (NO) -related signaling.	Nitric Oxide	83-95	interleukin 1 beta	Homo sapiens	27-35
11094861-2	2000	RESULTS: IL-1 beta and TNF-alpha caused a prominent PMN-mediated 51Cr release that was dose-dependently reduced when auranofin (AF) or gold sodium aurothiomalate (GSTM) were added to PMN and HUVEC in the assay system.	Auranofin	117-126	interleukin 1 beta	Homo sapiens	9-18
11079466-4	2000	We examined whether the antioxidant N-acetylcysteine (NAC) inhibited COX-2 expression induced in the human osteoblastic cell line MG63 by interleukin-1beta (IL-1beta).	Acetylcysteine	36-52	interleukin 1 beta	Homo sapiens	138-155
11094861-2	2000	RESULTS: IL-1 beta and TNF-alpha caused a prominent PMN-mediated 51Cr release that was dose-dependently reduced when auranofin (AF) or gold sodium aurothiomalate (GSTM) were added to PMN and HUVEC in the assay system.	Gold Sodium Thiomalate	140-161	interleukin 1 beta	Homo sapiens	9-18
11079466-4	2000	We examined whether the antioxidant N-acetylcysteine (NAC) inhibited COX-2 expression induced in the human osteoblastic cell line MG63 by interleukin-1beta (IL-1beta).	Acetylcysteine	36-52	interleukin 1 beta	Homo sapiens	157-165
11079466-4	2000	We examined whether the antioxidant N-acetylcysteine (NAC) inhibited COX-2 expression induced in the human osteoblastic cell line MG63 by interleukin-1beta (IL-1beta).	Acetylcysteine	54-57	interleukin 1 beta	Homo sapiens	138-155
11053499-7	2000	The addition of MCFA (5 mmol/L) induced a 40% increase in IL-1beta-induced IL-8 secretion and a 35% increase in tumor necrosis factor (TNF)-alpha-induced IL-8 secretion, respectively.	mcfa	16-20	interleukin 1 beta	Homo sapiens	58-66
11079466-4	2000	We examined whether the antioxidant N-acetylcysteine (NAC) inhibited COX-2 expression induced in the human osteoblastic cell line MG63 by interleukin-1beta (IL-1beta).	Acetylcysteine	54-57	interleukin 1 beta	Homo sapiens	157-165
11079466-5	2000	According to Western blot and reverse transcription-polymerase chain reaction (RT-PCR) test results, NAC inhibited IL-1beta-induced COX-2 expression in protein and messenger RNA.	Acetylcysteine	101-104	interleukin 1 beta	Homo sapiens	115-123
11048965-3	2000	The stimulatory effect of PHT on IL-1beta-induced IL-6 production was strongly reduced by the specific cyclooxygenase-2 inhibitor NS-398 (1 microM).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	130-136	interleukin 1 beta	Homo sapiens	33-41
11032891-0	2000	Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB.	Dinoprostone	47-65	interleukin 1 beta	Homo sapiens	0-17
11032891-5	2000	Here we show that interleukin (IL)-1beta induces COX-2 mRNA and protein synthesis and the release of PGE(2) in the human neuroblastoma cell line SK-N-SH.	Dinoprostone	101-107	interleukin 1 beta	Homo sapiens	18-40
11048965-4	2000	The anti-inflammatory drug, dexamethasone (1 microM), abolished the production of both IL-6 and IL-8 in gingival fibroblasts challenged with PHT in the presence or absence of IL-1beta.	Dexamethasone	28-41	interleukin 1 beta	Homo sapiens	175-183
11069732-13	2000	As previously reported, the inhibition of NO synthesis by the competitive inhibitor L-NMMA led to enhancement of IL-6, IL-8 and PGE(2)production by IL-1 beta treated chondrocytes, but did not significantly modify IL-10, PG and MMP-3 productions.	omega-N-Methylarginine	84-90	interleukin 1 beta	Homo sapiens	148-157
11063815-7	2000	These results indicate that exogenous IL-1beta induces release of NO, PGE(2) and IL-6 in mixed glial cultures, and that endogenous IL-1beta mediates inflammatory actions of LPS on NO and to a lesser extent IL-6, but not on PGE(2) release in mixed glial cultures.	Prostaglandins E	223-226	interleukin 1 beta	Homo sapiens	131-139
11063815-8	2000	Indeed endogenous IL-1beta appears to inhibit LPS-induced PGE(2) release.	Dinoprostone	58-64	interleukin 1 beta	Homo sapiens	18-26
11063823-2	2000	In this study we report that IL-1beta concentrations were significantly increased in the hippocampus following subcutaneous (s.c.) injection of Pw, and that this was accompanied by increased activity of the stress-activated kinase, c-Jun-N-terminal kinase (JNK) and a decrease in glutamate release.	Glutamic Acid	280-289	interleukin 1 beta	Homo sapiens	29-37
11063823-4	2000	Incubation of hippocampal synaptosomes in the presence of Pw, PT or LPS also resulted in increased JNK activation and decreased glutamate release, effects which were mimicked by IL-1beta and blocked by the IL-1 receptor antagonist (IL-ra).	Glutamic Acid	128-137	interleukin 1 beta	Homo sapiens	178-186
11069728-7	2000	In primary human chondrocytes, IL-1 beta induction of p38 MAP kinase was inhibited by SB 242235 with an IC(50)of approximately 1 microM.	SB 242235	86-95	interleukin 1 beta	Homo sapiens	31-40
11063815-5	2000	Incubation with human recombinant IL-1beta (100 ng/ml) also stimulated NO and IL-6 release to a similar extent to LPS, but IL-1beta (1 or 100 ng/ml) caused only modest increases (approximately seven-fold) in PGE(2) release.	Prostaglandins E	208-211	interleukin 1 beta	Homo sapiens	34-42
11063815-7	2000	These results indicate that exogenous IL-1beta induces release of NO, PGE(2) and IL-6 in mixed glial cultures, and that endogenous IL-1beta mediates inflammatory actions of LPS on NO and to a lesser extent IL-6, but not on PGE(2) release in mixed glial cultures.	Prostaglandins E	70-73	interleukin 1 beta	Homo sapiens	38-46
11069732-13	2000	As previously reported, the inhibition of NO synthesis by the competitive inhibitor L-NMMA led to enhancement of IL-6, IL-8 and PGE(2)production by IL-1 beta treated chondrocytes, but did not significantly modify IL-10, PG and MMP-3 productions.	Prostaglandins E	128-131	interleukin 1 beta	Homo sapiens	148-157
11005841-2	2000	Here we report that gamma-tocopherol (gammaT) reduced PGE(2) synthesis in both lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and IL-1beta-treated A549 human epithelial cells with an apparent IC(50) of 7.5 and 4 microM, respectively.	gamma-Tocopherol	20-36	interleukin 1 beta	Homo sapiens	140-148
11069732-15	2000	CONCLUSIONS: These findings suggest that IFN gamma and IL-1 synergistically stimulate the production of IL-6, IL-1ra, NO and PGE(2)and inhibit PG synthesis.	Prostaglandins E	125-128	interleukin 1 beta	Homo sapiens	55-59
11069732-8	2000	RESULTS: As expected, IL-1 beta highly stimulated NO, IL-6, IL-8, IL-10, IL-1ra, PGE(2)and stromelysin synthesis, but dramatically decreased PG production.	Prostaglandins E	81-84	interleukin 1 beta	Homo sapiens	22-31
11035104-0	2000	ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	64-73
11035104-6	2000	Quantities of IL-1beta generated by an individual donor"s blood in response to the LPS-only and LPS/ATP stimuli were relatively consistent over the 4-day period.	Adenosine Triphosphate	100-103	interleukin 1 beta	Homo sapiens	14-22
11005841-2	2000	Here we report that gamma-tocopherol (gammaT) reduced PGE(2) synthesis in both lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and IL-1beta-treated A549 human epithelial cells with an apparent IC(50) of 7.5 and 4 microM, respectively.	gamma-Tocopherol	38-44	interleukin 1 beta	Homo sapiens	140-148
11037876-8	2000	Tau-Cl, but not Tau, reduced IL-1beta-triggered cytokine mRNA expression, exerting stronger inhibitory activity on the levels of IL-6 than on those of IL-8.	N-chlorotaurine	0-6	interleukin 1 beta	Homo sapiens	29-37
11104367-3	2000	Nifedipine significantly decreased the expression of luciferase protein stimulated with IL-1beta (1 ng/mL) compared with controls: 80+/-4% at 3 micromol/L, 47+/-2% at 10 micromol/L and 30+/-2% at 30 micromol/L (each, n=3, p&lt;0.0001).	Nifedipine	0-10	interleukin 1 beta	Homo sapiens	88-96
11011042-3	2000	Interleukin-1beta was most potent in increasing the sarafotoxin-induced contraction in cultured segments.	sarafotoxin	52-63	interleukin 1 beta	Homo sapiens	0-17
11000126-7	2000	Antibodies to interleukin-1beta and tumor necrosis factor-alpha blocked the monocyte inhibitory effect and reduced the amount of PGE(2) produced.	Prostaglandins E	129-132	interleukin 1 beta	Homo sapiens	14-63
11017919-9	2000	Compared with exposure to air, exposure to CS led to a significantly increased release of these mediators from cultures of the never-smoker group (mean 250.0% increase in IL-1beta and mean 175.3% increase in sICAM-1 24 h after exposure) and COPD group (mean 383.3% increase in IL-1beta and mean 97.4% increase in sICAM-1 24 h after exposure).	Cesium	43-45	interleukin 1 beta	Homo sapiens	171-179
11017919-9	2000	Compared with exposure to air, exposure to CS led to a significantly increased release of these mediators from cultures of the never-smoker group (mean 250.0% increase in IL-1beta and mean 175.3% increase in sICAM-1 24 h after exposure) and COPD group (mean 383.3% increase in IL-1beta and mean 97.4% increase in sICAM-1 24 h after exposure).	Cesium	43-45	interleukin 1 beta	Homo sapiens	277-285
11017919-14	2000	These results suggest that whereas smokers with or without COPD demonstrate increased levels of GSH within bronchial epithelial cell cultures, those with COPD have a greater susceptibility to the effects of CS in reducing GSH levels and causing increased permeability and release of proinflammatory mediators such as IL-1beta and sICAM-1.	Cesium	207-209	interleukin 1 beta	Homo sapiens	317-325
11031204-6	2000	Electromobility gel shift and luciferase assays demonstrated that overexpression of IkappaBDeltaN inhibited NF-kappaB activation induced by TNF-alpha or interleukin-1beta (IL-1beta).	ikappabdeltan	84-97	interleukin 1 beta	Homo sapiens	153-170
11031204-6	2000	Electromobility gel shift and luciferase assays demonstrated that overexpression of IkappaBDeltaN inhibited NF-kappaB activation induced by TNF-alpha or interleukin-1beta (IL-1beta).	ikappabdeltan	84-97	interleukin 1 beta	Homo sapiens	172-180
11037895-2	2000	OBJECTIVE: To evaluate the efficacy and safety of diacerein, a drug with interleukin-1beta--inhibitory activity in vitro, in patients with knee osteoarthritis (OA).	diacerein	50-59	interleukin 1 beta	Homo sapiens	73-90
11037878-10	2000	The levels of COL2A1 and aggrecan mRNA were increased after transfer from monolayer to alginate culture at 32 degrees C. Treatment with IL-1beta decreased COL2A1 and aggrecan mRNA levels and increased the levels of matrix metalloproteinases 1, 3, and 13 mRNA, as well as those of cyclooxygenase 2, type I collagen, and secretory phospholipase A2 type IIA mRNA, but not those of inducible nitric oxide synthase mRNA.	Alginates	87-95	interleukin 1 beta	Homo sapiens	136-144
11037878-12	2000	The p38 MAPK-selective inhibitor, SB203580, partially reversed IL-1beta-induced inhibition of COL2A1 mRNA levels and COL2A1-luciferase reporter gene expression.	SB 203580	34-42	interleukin 1 beta	Homo sapiens	63-71
11015296-2	2000	In other tissues, oncostatin M (OSM), a potent inducer of epithelial antiproteases, has also been shown to interact with IL-1beta to stimulate PGE(2) release.	Prostaglandins E	143-146	interleukin 1 beta	Homo sapiens	121-129
11015296-5	2000	Cells treated with a mixture of IL-1beta, IFNgamma and LPS for 48 h produced a 9 fold increase in PGE(2) and a 3 fold increase in NO levels (both P&lt;0.05).	Prostaglandins E	98-101	interleukin 1 beta	Homo sapiens	32-40
11014242-8	2000	Conversion of androgen to estrogen was effectively stimulated by phorbol myristate acetate and dexamethasone plus interleukin-1beta and was completely abolished by selective inhibitors of aromatase P450 (fadrozole and TZA-2209), but not by inhibitors of 5alpha-reductase (finasteride and flutamide).	TZA 2209	218-226	interleukin 1 beta	Homo sapiens	114-131
11039768-6	2000	Human interleukin-1beta (5-10 ng/mL) induced nitric oxide, prostaglandin E2 and matrix metalloprotease production in bovine or human chondrocytes, which could be inhibited by 500 pg/mL of Type II interleukin-1 receptor.	Nitric Oxide	45-57	interleukin 1 beta	Homo sapiens	6-23
11039768-6	2000	Human interleukin-1beta (5-10 ng/mL) induced nitric oxide, prostaglandin E2 and matrix metalloprotease production in bovine or human chondrocytes, which could be inhibited by 500 pg/mL of Type II interleukin-1 receptor.	Dinoprostone	59-75	interleukin 1 beta	Homo sapiens	6-23
11827727-0	2000	Pentoxifylline potentiates nitric oxide production in interleukin-1beta-stimulated vascular smooth muscle cells through cyclic AMP-dependent protein kinase A pathway.	Pentoxifylline	0-14	interleukin 1 beta	Homo sapiens	54-71
11827727-0	2000	Pentoxifylline potentiates nitric oxide production in interleukin-1beta-stimulated vascular smooth muscle cells through cyclic AMP-dependent protein kinase A pathway.	Nitric Oxide	27-39	interleukin 1 beta	Homo sapiens	54-71
11827727-1	2000	In the present study, we observed that pentoxifylline (PTX) significantly augmented the nitric oxide (NO) production and the iNOS gene expression by interleukin-1beta (IL-1beta)-stimulated vascular smooth muscle cells (VSMCs).	Pentoxifylline	39-53	interleukin 1 beta	Homo sapiens	149-166
11827727-1	2000	In the present study, we observed that pentoxifylline (PTX) significantly augmented the nitric oxide (NO) production and the iNOS gene expression by interleukin-1beta (IL-1beta)-stimulated vascular smooth muscle cells (VSMCs).	Pentoxifylline	39-53	interleukin 1 beta	Homo sapiens	168-176
11827727-1	2000	In the present study, we observed that pentoxifylline (PTX) significantly augmented the nitric oxide (NO) production and the iNOS gene expression by interleukin-1beta (IL-1beta)-stimulated vascular smooth muscle cells (VSMCs).	Pentoxifylline	55-58	interleukin 1 beta	Homo sapiens	149-166
11827727-1	2000	In the present study, we observed that pentoxifylline (PTX) significantly augmented the nitric oxide (NO) production and the iNOS gene expression by interleukin-1beta (IL-1beta)-stimulated vascular smooth muscle cells (VSMCs).	Pentoxifylline	55-58	interleukin 1 beta	Homo sapiens	168-176
11827727-1	2000	In the present study, we observed that pentoxifylline (PTX) significantly augmented the nitric oxide (NO) production and the iNOS gene expression by interleukin-1beta (IL-1beta)-stimulated vascular smooth muscle cells (VSMCs).	Nitric Oxide	88-100	interleukin 1 beta	Homo sapiens	168-176
11827727-2	2000	The enhancing effects of PTX on the IL-1beta-induced NO production was associated with an increased intracellular cyclic AMP (cAMP) levels, and the synergistic effects of PTX on the IL-1beta-induced NO production was blocked by cAMP-dependent protein kinase A (PKA) inhibitors.	Pentoxifylline	25-28	interleukin 1 beta	Homo sapiens	36-44
11827727-2	2000	The enhancing effects of PTX on the IL-1beta-induced NO production was associated with an increased intracellular cyclic AMP (cAMP) levels, and the synergistic effects of PTX on the IL-1beta-induced NO production was blocked by cAMP-dependent protein kinase A (PKA) inhibitors.	Cyclic AMP	114-124	interleukin 1 beta	Homo sapiens	36-44
11827727-2	2000	The enhancing effects of PTX on the IL-1beta-induced NO production was associated with an increased intracellular cyclic AMP (cAMP) levels, and the synergistic effects of PTX on the IL-1beta-induced NO production was blocked by cAMP-dependent protein kinase A (PKA) inhibitors.	Cyclic AMP	126-130	interleukin 1 beta	Homo sapiens	36-44
11827727-2	2000	The enhancing effects of PTX on the IL-1beta-induced NO production was associated with an increased intracellular cyclic AMP (cAMP) levels, and the synergistic effects of PTX on the IL-1beta-induced NO production was blocked by cAMP-dependent protein kinase A (PKA) inhibitors.	Pentoxifylline	171-174	interleukin 1 beta	Homo sapiens	182-190
11827727-4	2000	In addition, the pretreatment with KT5720 or H89 abolished the increased translocation of the p65 subunit of NF-kappaB into the nucleus by PTX in the IL-1beta-stimulated VSMCs.	Pentoxifylline	139-142	interleukin 1 beta	Homo sapiens	150-158
11827727-5	2000	These results suggest that enhancing effects of PTX on the iNOS gene expression in the IL-1beta-stimulated VSMCs is mediated predominantly through the activation of NF-kappaB via cAMP-dependent PKA pathway.	Pentoxifylline	48-51	interleukin 1 beta	Homo sapiens	87-95
11827727-5	2000	These results suggest that enhancing effects of PTX on the iNOS gene expression in the IL-1beta-stimulated VSMCs is mediated predominantly through the activation of NF-kappaB via cAMP-dependent PKA pathway.	Cyclic AMP	179-183	interleukin 1 beta	Homo sapiens	87-95
11034404-7	2000	Furthermore, IL-1beta attenuated IFN-alphabeta-induced STAT1 binding and tyrosine phosphorylation without affecting the level of STAT1 protein.	Tyrosine	73-81	interleukin 1 beta	Homo sapiens	13-21
11775830-3	2000	Western blot was applied to examine transient changes in protein tyrosine phosphorylation status and MAPKs activation in RA FLS stimulated with IL-1 beta at various doses, and over different periods.	Tyrosine	65-73	interleukin 1 beta	Homo sapiens	144-153
11775830-4	2000	Genistein, the specific PTK inhibitor, was used to evaluate the inhibitory role in activation of MAPKs by IL-1 beta.	Genistein	0-9	interleukin 1 beta	Homo sapiens	106-115
11775830-5	2000	RESULTS: IL-1 beta transiently increased protein tyrosine phosphorylation, and activated the MAPKs cascades (mainly ERK2, JNK2 and P38) in RA FLS.	Tyrosine	49-57	interleukin 1 beta	Homo sapiens	9-18
11775830-8	2000	CONCLUSIONS: During signal transduction of IL-1 beta in RA FLS, tyrosine phosphorylation was increased transiently, the MAPKs cascade was activated in a few minutes, and there was heterogenicity in the activation among three subfamily members.	Tyrosine	64-72	interleukin 1 beta	Homo sapiens	43-52
11034404-4	2000	Administration of IL-1beta in vivo attenuated IFN-alphabeta-induced STAT1 tyrosine phosphorylation in the liver but not in the spleen.	Tyrosine	74-82	interleukin 1 beta	Homo sapiens	18-26
11014242-9	2000	The apparent Km of androstenedione was 3 nM in the presence of dexamethasone and interleukin-1beta, corresponding to the plasma concentration of androstenedione in women of reproductive age.	Androstenedione	19-34	interleukin 1 beta	Homo sapiens	81-98
11014242-9	2000	The apparent Km of androstenedione was 3 nM in the presence of dexamethasone and interleukin-1beta, corresponding to the plasma concentration of androstenedione in women of reproductive age.	Androstenedione	145-160	interleukin 1 beta	Homo sapiens	81-98
10996652-0	2000	Interleukin-1beta increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron pool.	Iron	43-47	interleukin 1 beta	Homo sapiens	0-17
10996652-4	2000	We evaluated the effects of interleukin-1beta (IL-1beta) on iron metabolism in human astrocytoma cells (SW1088).	Iron	60-64	interleukin 1 beta	Homo sapiens	28-45
10996652-4	2000	We evaluated the effects of interleukin-1beta (IL-1beta) on iron metabolism in human astrocytoma cells (SW1088).	Iron	60-64	interleukin 1 beta	Homo sapiens	47-55
10996652-6	2000	Using the iron sensitive dye calcein, we determined that the intracellular labile iron pool increased within 4 h of IL-1beta exposure and continued to increase for 8 h, returning to normal by 16 h. We propose that the cytokine induced increase in the labile iron pool stimulates ferritin synthesis resulting in a subsequent decrease in the labile iron pool.	Iron	10-14	interleukin 1 beta	Homo sapiens	116-124
10996652-6	2000	Using the iron sensitive dye calcein, we determined that the intracellular labile iron pool increased within 4 h of IL-1beta exposure and continued to increase for 8 h, returning to normal by 16 h. We propose that the cytokine induced increase in the labile iron pool stimulates ferritin synthesis resulting in a subsequent decrease in the labile iron pool.	Iron	82-86	interleukin 1 beta	Homo sapiens	116-124
10996652-6	2000	Using the iron sensitive dye calcein, we determined that the intracellular labile iron pool increased within 4 h of IL-1beta exposure and continued to increase for 8 h, returning to normal by 16 h. We propose that the cytokine induced increase in the labile iron pool stimulates ferritin synthesis resulting in a subsequent decrease in the labile iron pool.	Iron	82-86	interleukin 1 beta	Homo sapiens	116-124
10996652-6	2000	Using the iron sensitive dye calcein, we determined that the intracellular labile iron pool increased within 4 h of IL-1beta exposure and continued to increase for 8 h, returning to normal by 16 h. We propose that the cytokine induced increase in the labile iron pool stimulates ferritin synthesis resulting in a subsequent decrease in the labile iron pool.	Iron	82-86	interleukin 1 beta	Homo sapiens	116-124
11006954-4	2000	The induction of ICAM-1 by cytokines such as interleukin 1beta or tumour necrosis factor TNF as well as by lipopolysaccharide or T3 can be suppressed by the two anti-inflammatory compounds dexamethasone and parthenolide.	Dexamethasone	189-202	interleukin 1 beta	Homo sapiens	45-62
10988243-5	2000	Resting SMCs and SMCs stimulated with phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide (LPS), interleukin (IL)-1beta, and tumor necrosis factor (TNF)-alpha formed PGE(2) and PGI(2) (evaluated as 6-oxo-PGF(1alpha)), and in the presence of SnCl(2) only a small amount of PGE(2) was deviated toward PGF(2alpha).	Prostaglandins E	172-175	interleukin 1 beta	Homo sapiens	103-125
10975802-8	2000	Octreotide, which mainly stimulates somatostatin receptor subtypes 2 and 5, affected the secretion of IL-8 and IL-1beta similarly, and the somatostatin antagonist cyclo-somatostatin completely blocked the somatostatin- and octreotide-induced inhibitory effects.	Octreotide	0-10	interleukin 1 beta	Homo sapiens	111-119
11006954-4	2000	The induction of ICAM-1 by cytokines such as interleukin 1beta or tumour necrosis factor TNF as well as by lipopolysaccharide or T3 can be suppressed by the two anti-inflammatory compounds dexamethasone and parthenolide.	parthenolide	207-219	interleukin 1 beta	Homo sapiens	45-62
11000287-7	2000	Analysis of DC supernatants after treatment with PG demonstrated significantly higher amounts of the proinflammatory cytokines IL-1 beta, IL-6, TNF-alpha, and IL-12.	Prostaglandins	49-51	interleukin 1 beta	Homo sapiens	127-136
10947757-5	2000	Before incision, in both groups IL-1beta and IFN-gamma showed a decrease (p&lt;0.01 for IL-1beta in isoflurane group and p&lt;0.05 for the others) compared with pre-induction.	Isoflurane	100-110	interleukin 1 beta	Homo sapiens	32-40
10947757-5	2000	Before incision, in both groups IL-1beta and IFN-gamma showed a decrease (p&lt;0.01 for IL-1beta in isoflurane group and p&lt;0.05 for the others) compared with pre-induction.	Isoflurane	100-110	interleukin 1 beta	Homo sapiens	88-96
11022126-3	2000	Control experiments revealed that 10- 6 M dexamethasone inhibited the TNF-alpha- or IL-1beta-mediated increase of IL-8 mRNA in A549 cells, which showed that the glucocorticoid was functional.	Dexamethasone	42-55	interleukin 1 beta	Homo sapiens	84-92
10991918-6	2000	AACOCF(3), HELSS, MAFP and PACOCF(3) significantly inhibited both EGF and IL-1beta stimulated (3)H-AA and PGE(2) release as well as cell proliferation.	Prostaglandins E	106-109	interleukin 1 beta	Homo sapiens	74-82
10991918-7	2000	Apigenin and PD 98509 significantly inhibited both EGF and IL-1beta stimulated (3)H-AA and PGE(2) release and cell proliferation whereas, SB 203580 had no significant effect on EGF or IL-1beta stimulated (3)H-AA release, or cell proliferation but significantly suppressed EGF or IL-1beta stimulated PGE(2) release.	Prostaglandins E	91-94	interleukin 1 beta	Homo sapiens	59-67
10965886-8	2000	The ability of IL-1beta to stimulate the expression of IGFBP-1 and the phosphorylation of the above kinases was specifically inhibited by PD98059, a MEK-1 inhibitor.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	138-145	interleukin 1 beta	Homo sapiens	15-23
10978250-5	2000	The upregulation of P2Y(2) receptor mRNA was paralleled at the functional level because IL-1beta significantly increased the UTP-stimulated DNA synthesis and the release of intracellular Ca(2+).	Uridine Triphosphate	125-128	interleukin 1 beta	Homo sapiens	88-96
10978250-6	2000	Actinomycin D completely blocked the upregulation of P2Y(2) receptor mRNA expression by IL-1beta, indicating de novo mRNA synthesis.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	88-96
10978250-8	2000	The cyclooxygenase inhibitor indomethacin and the protein kinase C inhibitor RO-31-8220 inhibited IL-1beta-induced upregulation of P2Y(2) receptor mRNA expression, whereas rapamycin and PD098059 had no effects.	Indomethacin	29-41	interleukin 1 beta	Homo sapiens	98-106
10978250-8	2000	The cyclooxygenase inhibitor indomethacin and the protein kinase C inhibitor RO-31-8220 inhibited IL-1beta-induced upregulation of P2Y(2) receptor mRNA expression, whereas rapamycin and PD098059 had no effects.	Ro 31-8220	77-87	interleukin 1 beta	Homo sapiens	98-106
10854431-12	2000	Tyr-Val-Ala-Asp-chloromethyl ketone, a caspase-1 inhibitor, prevented ATP-induced release of processed interleukin-1beta, but not ATP-dependent SAPK activity.	Tyr-Val-Ala-Asp-chloromethyl ketone	0-35	interleukin 1 beta	Homo sapiens	103-120
10854431-12	2000	Tyr-Val-Ala-Asp-chloromethyl ketone, a caspase-1 inhibitor, prevented ATP-induced release of processed interleukin-1beta, but not ATP-dependent SAPK activity.	Adenosine Triphosphate	70-73	interleukin 1 beta	Homo sapiens	103-120
10958685-0	2000	Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.	Lysine	122-129	interleukin 1 beta	Homo sapiens	70-87
10976994-8	2000	Interleukin-1beta (IL-1beta and prostaglandin E2 (PGE2) were identified as candidate molecules for the transferable factor as both were shown to induce HBC hyperpolarization by opening of small conductance calcium-activated potassium channels, the means by which 0.33 Hz PIS causes HBC hyperpolarization.	Dinoprostone	50-54	interleukin 1 beta	Homo sapiens	0-17
10976994-8	2000	Interleukin-1beta (IL-1beta and prostaglandin E2 (PGE2) were identified as candidate molecules for the transferable factor as both were shown to induce HBC hyperpolarization by opening of small conductance calcium-activated potassium channels, the means by which 0.33 Hz PIS causes HBC hyperpolarization.	Monothiopyrophosphoric acid	271-274	interleukin 1 beta	Homo sapiens	0-17
10976994-9	2000	Antibodies to IL-1beta, but not other cytokines studied, inhibit the hyperpolarization response of HBC to 0.33 Hz PIS.	Monothiopyrophosphoric acid	114-117	interleukin 1 beta	Homo sapiens	14-22
10976994-10	2000	Comparison of the signaling pathways required for 0.33 Hz PIS and IL-1beta-induced membrane hyperpolarization shows that both involve the phospholipase C/inositol triphosphate pathway, protein kinase C (PKC), and prostaglandin synthesis.	Inositol triphosphate	154-175	interleukin 1 beta	Homo sapiens	66-74
10976994-10	2000	Comparison of the signaling pathways required for 0.33 Hz PIS and IL-1beta-induced membrane hyperpolarization shows that both involve the phospholipase C/inositol triphosphate pathway, protein kinase C (PKC), and prostaglandin synthesis.	Prostaglandins	213-226	interleukin 1 beta	Homo sapiens	66-74
10976994-12	2000	These studies suggest that 0.33 Hz PIS of HBC induces a rapid, integrin-mediated, release of IL-1beta with a subsequent autocrine/paracrine loop resulting in membrane hyperpolarization.	Monothiopyrophosphoric acid	35-38	interleukin 1 beta	Homo sapiens	93-101
10999850-6	2000	Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398.	Arachidonic Acid	373-389	interleukin 1 beta	Homo sapiens	92-109
10999850-6	2000	Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398.	Arachidonic Acid	373-389	interleukin 1 beta	Homo sapiens	111-119
10999850-6	2000	Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398.	Arachidonic Acid	373-389	interleukin 1 beta	Homo sapiens	212-220
10999850-6	2000	Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398.	Prostaglandins	393-404	interleukin 1 beta	Homo sapiens	92-109
10999850-6	2000	Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398.	Prostaglandins	393-404	interleukin 1 beta	Homo sapiens	111-119
10999850-6	2000	Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398.	Prostaglandins	393-404	interleukin 1 beta	Homo sapiens	212-220
10999850-6	2000	Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	465-471	interleukin 1 beta	Homo sapiens	92-109
10999850-6	2000	Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	465-471	interleukin 1 beta	Homo sapiens	111-119
10999850-6	2000	Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	465-471	interleukin 1 beta	Homo sapiens	212-220
10958685-1	2000	We have investigated the ability of dexamethasone to regulate interleukin-1beta (IL-1beta)-induced gene expression, histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity.	Dexamethasone	36-49	interleukin 1 beta	Homo sapiens	62-79
10958685-1	2000	We have investigated the ability of dexamethasone to regulate interleukin-1beta (IL-1beta)-induced gene expression, histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity.	Dexamethasone	36-49	interleukin 1 beta	Homo sapiens	81-89
10958685-2	2000	Low concentrations of dexamethasone (10(-10) M) repress IL-1beta-stimulated granulocyte-macrophage colony-stimulating factor (GM-CSF) expression and fail to stimulate secretory leukocyte proteinase inhibitor expression.	Dexamethasone	22-35	interleukin 1 beta	Homo sapiens	56-64
10958685-5	2000	Low concentrations of dexamethasone (10(-10) M), which do not transactivate, repressed IL-1beta-stimulated K8 and K12 acetylation.	Dexamethasone	22-35	interleukin 1 beta	Homo sapiens	87-95
10958685-6	2000	Using chromatin immunoprecipitation assays, we show that dexamethasone inhibits IL-1beta-enhanced acetylated K8-associated GM-CSF promoter enrichment in a concentration-dependent manner.	Dexamethasone	57-70	interleukin 1 beta	Homo sapiens	80-88
11045021-6	2000	Pre-treatment with interleukin-1 beta showed a similar significant enhancement of the histamine-induced [Ca2+]i response, while pre-treatment with high concentrations of serum or interleukin-6 did not change the [Ca2+]i response.	Histamine	86-95	interleukin 1 beta	Homo sapiens	19-37
11028539-4	2000	Inhibition of caspase activity by Z-VAD significantly reduced lipopolysaccharide (LPS) and Staphylococcus aureus (SAC) induced release of mature IL-1beta in septic patients and controls.	z-vad	34-39	interleukin 1 beta	Homo sapiens	145-153
10956548-5	2000	Point mutations of NF-IL6 and cAMP response element (CRE) in this region reduced both basal and IL-1 beta-stimulated production of CAT; dual mutation eliminated IL-1 beta responsiveness.	Cyclic AMP	30-34	interleukin 1 beta	Homo sapiens	96-105
10956548-5	2000	Point mutations of NF-IL6 and cAMP response element (CRE) in this region reduced both basal and IL-1 beta-stimulated production of CAT; dual mutation eliminated IL-1 beta responsiveness.	Cyclic AMP	30-34	interleukin 1 beta	Homo sapiens	161-170
11028561-11	2000	Geldanamycin, which has been shown in studies to inhibit AP-1 activation, blocked IL-1beta-induced AP-1 luciferase gene activation and IL-6 production.	geldanamycin	0-12	interleukin 1 beta	Homo sapiens	82-90
10983854-0	2000	Methylenedioxymethamphetamine (MDMA; Ecstasy) suppresses IL-1beta and TNF-alpha secretion following an in vivo lipopolysaccharide challenge.	N-Methyl-3,4-methylenedioxyamphetamine	0-29	interleukin 1 beta	Homo sapiens	57-65
10983854-0	2000	Methylenedioxymethamphetamine (MDMA; Ecstasy) suppresses IL-1beta and TNF-alpha secretion following an in vivo lipopolysaccharide challenge.	N-Methyl-3,4-methylenedioxyamphetamine	31-35	interleukin 1 beta	Homo sapiens	57-65
10983854-5	2000	The suppressive effect of MDMA on IL-1beta secretion was transient and returned to control levels within 3 hours of administration.	N-Methyl-3,4-methylenedioxyamphetamine	26-30	interleukin 1 beta	Homo sapiens	34-42
10983854-8	2000	on LPS-induced IL-1beta and TNF-alpha secretion, and demonstrated that all three doses potently suppressed LPS-induced TNF-alpha secretion, but only MDMA 10 and 20 mg/kg suppressed LPS-induced IL-1beta secretion.	N-Methyl-3,4-methylenedioxyamphetamine	149-153	interleukin 1 beta	Homo sapiens	193-201
10983854-12	2000	In conclusion, these data demonstrate that acute MDMA administration impairs IL-1beta and TNF-alpha secretion following an in vivo LPS challenge, and that TNF-alpha is more sensitive to the suppressive effects of MDMA than is IL-1beta.	N-Methyl-3,4-methylenedioxyamphetamine	49-53	interleukin 1 beta	Homo sapiens	77-85
10925316-8	2000	We transiently knocked out RelA from IMF monocytes with antisense oligonucleotides and showed that RelA is central to IL-1 and TGF-beta production and to the adhesion of IMF monocytes.	Oligonucleotides	66-82	interleukin 1 beta	Homo sapiens	118-122
10913367-3	2000	Thymulin selectively ameliorated, in a dose-dependent manner, the endotoxin-induced release of IL-1 beta (IC(50) = 657 ng.	Thymic Factor, Circulating	0-8	interleukin 1 beta	Homo sapiens	95-104
10924071-4	2000	In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 beta	Homo sapiens	64-72
10924071-4	2000	In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production.	Dinoprostone	99-105	interleukin 1 beta	Homo sapiens	45-62
10924071-4	2000	In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production.	Dinoprostone	99-105	interleukin 1 beta	Homo sapiens	64-72
10924071-13	2000	These findings indicate that: 1) PMA, acting through PKC and p38 kinase, enhances COX-2 expression, but chronic treatment with PMA partially inhibits IL-1beta stimulation of COX-2; and 2) exogenous PGF(2alpha) is involved in neonatal ventricular myocyte growth but endogenous COX-2 products are not.	Prostaglandins F	198-201	interleukin 1 beta	Homo sapiens	150-158
10989981-1	2000	The in vitro effect of cefotaxime on the production of interleukin (IL)-1beta, IL-2, IL-6 and tumor necrosis factor alpha (TNFalpha) was studied in term neonates and was compared with that of adults.	Cefotaxime	23-33	interleukin 1 beta	Homo sapiens	55-77
10928971-0	2000	FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells.	Tacrolimus	0-5	interleukin 1 beta	Homo sapiens	64-72
10930295-2	2000	Interleukin 1beta (IL-1beta) and tumour necrosis factor-alpha (TNF), phorbol myristate acetate (PMA) and calcium ionophore A(23187)increased the extracellular AA release, and stimulated eicosanoid synthesis as determined by HPLC analysis.	Eicosanoids	186-196	interleukin 1 beta	Homo sapiens	0-17
10928971-1	2000	The aim of this study was to elucidate the in vitro inhibitory potency of FK506 on production of the inflammatory cytokines, tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta, with a view to assessing this immunosuppressive agent as a potential anti-rheumatic drug.	Tacrolimus	74-79	interleukin 1 beta	Homo sapiens	164-186
10928971-4	2000	FK506 inhibited anti-CD3/CD28 induced TNF-alpha and IL-1beta production at concentrations less than 1 ng ml(-1).	Tacrolimus	0-5	interleukin 1 beta	Homo sapiens	52-60
10928971-5	2000	Flow cytometric analysis of intracellular TNF-alpha and IL-1beta positive cells showed that FK506 potently suppresses inflammatory cytokine production from CD14+ monocytes as well as from T cells.	Tacrolimus	92-97	interleukin 1 beta	Homo sapiens	56-64
10930295-2	2000	Interleukin 1beta (IL-1beta) and tumour necrosis factor-alpha (TNF), phorbol myristate acetate (PMA) and calcium ionophore A(23187)increased the extracellular AA release, and stimulated eicosanoid synthesis as determined by HPLC analysis.	Eicosanoids	186-196	interleukin 1 beta	Homo sapiens	19-27
10930295-3	2000	The main metabolites after stimulation with IL-1beta, PMA or A(23187)were PGE(2), an unidentified PG and LTB(4), while TNF stimulated HETE-production.	Prostaglandins E	74-77	interleukin 1 beta	Homo sapiens	44-52
10930295-3	2000	The main metabolites after stimulation with IL-1beta, PMA or A(23187)were PGE(2), an unidentified PG and LTB(4), while TNF stimulated HETE-production.	pg	74-76	interleukin 1 beta	Homo sapiens	44-52
10930295-3	2000	The main metabolites after stimulation with IL-1beta, PMA or A(23187)were PGE(2), an unidentified PG and LTB(4), while TNF stimulated HETE-production.	Leukotriene B4	105-108	interleukin 1 beta	Homo sapiens	44-52
10930295-6	2000	The selective npPLA(2)inhibitors LY311727 and 12-epi-scalaradial, or the cPLA(2)inhibitor arachidonyl trifluoro methyl ketone (AACOCF(3)) reduced IL-1beta-induced eicosanoid production in a concentration dependent manner.	arachidonyltrifluoromethane	90-125	interleukin 1 beta	Homo sapiens	146-154
10896792-0	2000	The regulation of PGE(2) biosynthesis in MG-63 osteosarcoma cells by IL-1 and FGF is cell density-dependent.	Dinoprostone	18-24	interleukin 1 beta	Homo sapiens	69-73
10896792-1	2000	We investigated the molecular mechanisms by which treatment of the human osteoblast-like cell line MG-63 with interleukin 1beta (IL-1) and/or fibroblast growth factor 1 (FGF-1) elicited prostaglandin biosynthesis.	Prostaglandins	186-199	interleukin 1 beta	Homo sapiens	110-127
10896792-9	2000	We also discovered that induction of PGE(2) biosynthesis in response to IL-1 or IL-1/FGF-1 was affected by the density of MG-63 cells in culture.	Dinoprostone	37-43	interleukin 1 beta	Homo sapiens	72-76
10896792-1	2000	We investigated the molecular mechanisms by which treatment of the human osteoblast-like cell line MG-63 with interleukin 1beta (IL-1) and/or fibroblast growth factor 1 (FGF-1) elicited prostaglandin biosynthesis.	Prostaglandins	186-199	interleukin 1 beta	Homo sapiens	129-133
10896792-9	2000	We also discovered that induction of PGE(2) biosynthesis in response to IL-1 or IL-1/FGF-1 was affected by the density of MG-63 cells in culture.	Dinoprostone	37-43	interleukin 1 beta	Homo sapiens	80-84
10896792-2	2000	IL-1 induced a 5-fold increase in PGE(2) production compared to controls.	Prostaglandins E	34-37	interleukin 1 beta	Homo sapiens	0-4
10896792-11	2000	The decreased PGE(2) induction by IL-1 in confluent cultures was associated with reduced IL-1 receptor expression.	Prostaglandins E	14-17	interleukin 1 beta	Homo sapiens	34-38
10896792-3	2000	While treatment with FGF-1 alone did not affect PGE(2) biosynthesis, it enhanced the formation of PGE(2) by IL-1 by an additional 3- to 5-fold.	Prostaglandins E	98-101	interleukin 1 beta	Homo sapiens	108-112
10896792-11	2000	The decreased PGE(2) induction by IL-1 in confluent cultures was associated with reduced IL-1 receptor expression.	Prostaglandins E	14-17	interleukin 1 beta	Homo sapiens	89-93
10896792-4	2000	IL-1-induced PGE(2) biosynthesis accompanied increases in steady-state levels of mRNAs encoding cPLA(2) (10- to 15-fold) and PGHS-2 (&gt;3-fold) and concomitant increases in cPLA(2) protein (&gt;3-fold) and PGHS-2 protein (&gt;1.	Prostaglandins E	13-16	interleukin 1 beta	Homo sapiens	0-4
10896792-12	2000	We conclude that the signaling pathways resulting in PGE(2) biosynthesis in response to proinflammatory agents like IL-1 are subject to complex regulation by additional soluble mediators as well as cell-cell or cell-extracellular matrix interactions.	Dinoprostone	53-59	interleukin 1 beta	Homo sapiens	116-120
10933353-7	2000	In patients with diet plus simvastatin, significant decreases of total cholesterol (-27%, p&lt;0.02), low density lipoprotein-cholesterol (-33%, p&lt;0.02), and monocyte expression of TNF (-49%, p&lt;0.02) and IL-1beta (-35%, p&lt;0.02) were observed.	Simvastatin	27-38	interleukin 1 beta	Homo sapiens	210-218
10932071-8	2000	Catechol (50 micromol/L) inhibited production of IL-2 and IL-1beta by 62% to 73% but had little effect on TNF-alpha or IFN-gamma production.	catechol	0-8	interleukin 1 beta	Homo sapiens	58-66
10932071-9	2000	In contrast, hydroquinone inhibited the production of all 4 cytokines with IC(50) values ranging from 3 micromol/L(IL-1beta) to 29 micromol/L (IFN-gamma).	hydroquinone	13-25	interleukin 1 beta	Homo sapiens	115-123
10900176-6	2000	DPI also inhibited TNF and LPS-induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha, LPS, or IL-1 beta induced VCAM-1 and ICAM-1 mRNA accumulation.	diphenyleneiodonium	0-3	interleukin 1 beta	Homo sapiens	105-114
10903761-5	2000	Additional studies to determine the specificity of this effect showed that although CQ reduced IL-1beta and IL-6 release, secretion of RANTES was unaffected.	Chloroquine	84-86	interleukin 1 beta	Homo sapiens	95-103
10937565-8	2000	Doxycycline inhibited the LPS-induced IL-1beta increase in the mRNA and protein amounts in the corneal epithelium and upregulated the expression of the anti-inflammatory IL-1 RA protein.	Doxycycline	0-11	interleukin 1 beta	Homo sapiens	38-46
10937565-11	2000	Doxycycline significantly decreased IL-1beta bioactivity in the supernatants from LPS-treated corneal epithelial cultures.	Doxycycline	0-11	interleukin 1 beta	Homo sapiens	36-44
10933353-8	2000	At the end of treatment period, patients treated with simvastatin had lower cholesterol and monocyte TNF and IL-1beta than did patients assigned to diet alone.	Simvastatin	54-65	interleukin 1 beta	Homo sapiens	109-117
10933353-9	2000	CONCLUSION: This study suggests that simvastatin possesses anti-inflammatory activity via the inhibition of pro-inflammatory cytokines TNF and IL-1beta expressed by monocytes.	Simvastatin	37-48	interleukin 1 beta	Homo sapiens	143-151
10884313-4	2000	Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1beta-stimulated expression of nitric oxide, tumor necrosis factor (TNFalpha), and IL-6 at both the protein and mRNA levels, without affecting cell viability.	Suramin	67-74	interleukin 1 beta	Homo sapiens	154-162
10791956-9	2000	The glucocorticoid receptor is responsible for a moderate stimulation of the promoter activity by dexamethasone and may interact with C/EBP factors to achieve a full transcription activity in basal conditions and in the presence of interleukin-1beta.	Dexamethasone	98-111	interleukin 1 beta	Homo sapiens	232-249
10906442-1	2000	It has been reported previously that in vitro treatment of human blood derived dendritic cells (DC) with contact allergens provokes the elevated expression of mRNA for interleukin (IL) 1beta, under conditions where similar treatment of cells with the non-sensitizing skin irritant sodium lauryl sulfate (SLS) did not alter IL-1beta mRNA levels (Reutter et al., 1997).	Sodium Dodecyl Sulfate	281-302	interleukin 1 beta	Homo sapiens	168-190
10906442-1	2000	It has been reported previously that in vitro treatment of human blood derived dendritic cells (DC) with contact allergens provokes the elevated expression of mRNA for interleukin (IL) 1beta, under conditions where similar treatment of cells with the non-sensitizing skin irritant sodium lauryl sulfate (SLS) did not alter IL-1beta mRNA levels (Reutter et al., 1997).	Sodium Dodecyl Sulfate	304-307	interleukin 1 beta	Homo sapiens	168-190
10906442-7	2000	Exposure to DNFB resulted in upregulation of IL-1beta mRNA (two- to threefold) in cells derived from three out of eight donors whereas IL-6 and IL-18 were largely unaffected by allergen exposure.	Dinitrofluorobenzene	12-16	interleukin 1 beta	Homo sapiens	45-53
10903904-4	2000	MUC2 transcripts were detected after 2 h of exposure to IL-1beta and reached maximal level after 8 h. Actinomycin D experiments indicated that the IL-1beta-mediated MUC2 expression was controlled by transcriptional regulation.	Dactinomycin	102-115	interleukin 1 beta	Homo sapiens	56-64
10903904-4	2000	MUC2 transcripts were detected after 2 h of exposure to IL-1beta and reached maximal level after 8 h. Actinomycin D experiments indicated that the IL-1beta-mediated MUC2 expression was controlled by transcriptional regulation.	Dactinomycin	102-115	interleukin 1 beta	Homo sapiens	147-155
10903904-5	2000	Both RT-PCR and FACS analysis showed that budesonide concomitantly attenuated IL-1beta mediated MUC2 gene as well as protein production levels.	Budesonide	42-52	interleukin 1 beta	Homo sapiens	78-86
10903904-6	2000	Use of the glucocorticoid receptor antagonist, RU-486, restored the inhibitory effect of budesonide on the IL-1beta-mediated MUC2 protein as well as gene.	Mifepristone	47-53	interleukin 1 beta	Homo sapiens	107-115
10903904-6	2000	Use of the glucocorticoid receptor antagonist, RU-486, restored the inhibitory effect of budesonide on the IL-1beta-mediated MUC2 protein as well as gene.	Budesonide	89-99	interleukin 1 beta	Homo sapiens	107-115
10903904-7	2000	The data suggest that IL-1beta up-regulates MUC2 gene by transcriptional regulation and that budesonide suppresses the IL-1beta-medicated MUC2 expression via decreased transcriptional activation.	Budesonide	93-103	interleukin 1 beta	Homo sapiens	119-127
10884313-4	2000	Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1beta-stimulated expression of nitric oxide, tumor necrosis factor (TNFalpha), and IL-6 at both the protein and mRNA levels, without affecting cell viability.	metaperiodate	79-88	interleukin 1 beta	Homo sapiens	154-162
10884313-4	2000	Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1beta-stimulated expression of nitric oxide, tumor necrosis factor (TNFalpha), and IL-6 at both the protein and mRNA levels, without affecting cell viability.	Adenosine Triphosphate	98-101	interleukin 1 beta	Homo sapiens	154-162
10884313-4	2000	Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1beta-stimulated expression of nitric oxide, tumor necrosis factor (TNFalpha), and IL-6 at both the protein and mRNA levels, without affecting cell viability.	2',3'-dialdehyde ATP	103-107	interleukin 1 beta	Homo sapiens	154-162
10884313-4	2000	Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a significant downregulation of IL-1beta-stimulated expression of nitric oxide, tumor necrosis factor (TNFalpha), and IL-6 at both the protein and mRNA levels, without affecting cell viability.	Nitric Oxide	188-200	interleukin 1 beta	Homo sapiens	154-162
10884313-6	2000	However, pretreatment with oATP downregulated activation of NF-kappaB and AP-1 by IL-1beta or TNFalpha.	2',3'-dialdehyde ATP	27-31	interleukin 1 beta	Homo sapiens	82-90
10873632-11	2000	Unexpectedly, 15d-PGJ(2) also drastically increased IL-1beta production, an indicator of macrophage activation, although PGE(1) only mildly increased it.	15d-pgj	14-21	interleukin 1 beta	Homo sapiens	52-60
10873632-12	2000	Additional enhancement of IL-1beta production was observed in the combination of PGE(1) and 15d-PGJ(2).	Prostaglandins E	81-84	interleukin 1 beta	Homo sapiens	26-34
10873632-12	2000	Additional enhancement of IL-1beta production was observed in the combination of PGE(1) and 15d-PGJ(2).	15d-pgj	92-99	interleukin 1 beta	Homo sapiens	26-34
10873157-6	2000	Expression of IL-1beta was sensitive only to PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	45-52	interleukin 1 beta	Homo sapiens	14-22
10873160-0	2000	Iron is a regulatory component of human IL-1beta production.	Iron	0-4	interleukin 1 beta	Homo sapiens	40-48
10873160-4	2000	Iron has been reported to influence the production of a number of proinflammatory mediators, including human interleukin (IL)-1beta.	Iron	0-4	interleukin 1 beta	Homo sapiens	109-131
10873160-5	2000	We postulated that we could (1) demonstrate regional differences in the release of IL-1beta from human alveolar macrophages and (2) influence the production of IL-1beta in human macrophages by altering intracellular iron concentrations.	Iron	216-220	interleukin 1 beta	Homo sapiens	83-91
10873160-5	2000	We postulated that we could (1) demonstrate regional differences in the release of IL-1beta from human alveolar macrophages and (2) influence the production of IL-1beta in human macrophages by altering intracellular iron concentrations.	Iron	216-220	interleukin 1 beta	Homo sapiens	160-168
10873160-7	2000	Additionally, we established an in vitro model of "iron-loaded" cells of the human myelomonocytic cell line THP-1 in order to examine more directly the effect of iron and its chelation on the secretion of IL-1beta.	Iron	51-55	interleukin 1 beta	Homo sapiens	205-213
10873160-7	2000	Additionally, we established an in vitro model of "iron-loaded" cells of the human myelomonocytic cell line THP-1 in order to examine more directly the effect of iron and its chelation on the secretion of IL-1beta.	Iron	162-166	interleukin 1 beta	Homo sapiens	205-213
10873160-8	2000	We report here that an intracellular, chelatable pool of iron expands with exogenous iron-loading as well as with lipopolysaccharide (LPS) stimulation and appears to suppress transcription of IL-1beta, whereas shrinkage of this pool by early chelation augments transcription of IL-1beta beyond that induced by LPS alone.	Iron	57-61	interleukin 1 beta	Homo sapiens	192-200
10873160-8	2000	We report here that an intracellular, chelatable pool of iron expands with exogenous iron-loading as well as with lipopolysaccharide (LPS) stimulation and appears to suppress transcription of IL-1beta, whereas shrinkage of this pool by early chelation augments transcription of IL-1beta beyond that induced by LPS alone.	Iron	57-61	interleukin 1 beta	Homo sapiens	278-286
10873160-9	2000	And finally, we demonstrate a regional relationship in the lung between excess alveolar iron and the production of human alveolar macrophage-derived IL-1beta, suggesting a partnership between iron and inflammation that may have clinical significance, especially in relation to lung diseases with a regional predominance.	Iron	88-92	interleukin 1 beta	Homo sapiens	149-157
10873160-9	2000	And finally, we demonstrate a regional relationship in the lung between excess alveolar iron and the production of human alveolar macrophage-derived IL-1beta, suggesting a partnership between iron and inflammation that may have clinical significance, especially in relation to lung diseases with a regional predominance.	Iron	192-196	interleukin 1 beta	Homo sapiens	149-157
10919362-5	2000	Astragaloside I also increased mRNA expression of the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) as measured using reverse transcriptase-polymerase chain reaction (RT)-PCR.	Astrasieversianin IV	0-15	interleukin 1 beta	Homo sapiens	77-94
10861141-9	2000	However, expression of TNF-alpha and IL-8, IFN-gamma, and IL-6 and IL-1beta was 2-20 times greater in patients administered 100% than in those administered 30% oxygen.	Oxygen	160-166	interleukin 1 beta	Homo sapiens	67-75
10919362-5	2000	Astragaloside I also increased mRNA expression of the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) as measured using reverse transcriptase-polymerase chain reaction (RT)-PCR.	Astrasieversianin IV	0-15	interleukin 1 beta	Homo sapiens	96-104
10926144-3	2000	IL-1beta was well removed through filtration during experimental HF using HFM (PAN&gt;CTA&gt;PMMA&gt;PS).	Polymethyl Methacrylate	93-97	interleukin 1 beta	Homo sapiens	0-8
10903976-7	2000	PD09059, UO126 and SB203580 prevented IL-1beta-induced PGE(2) release at doses that correlated closely with published IC(50) values.	SB 203580	19-27	interleukin 1 beta	Homo sapiens	38-46
10903976-0	2000	The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	27-35	interleukin 1 beta	Homo sapiens	65-73
10903976-7	2000	PD09059, UO126 and SB203580 prevented IL-1beta-induced PGE(2) release at doses that correlated closely with published IC(50) values.	Prostaglandins E	55-58	interleukin 1 beta	Homo sapiens	38-46
10903976-0	2000	The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.	U 0126	37-42	interleukin 1 beta	Homo sapiens	65-73
10903976-0	2000	The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.	SB 203580	47-55	interleukin 1 beta	Homo sapiens	65-73
10903976-13	2000	In contrast, UO126 was highly effective at inhibiting IL-1beta-dependent arachidonate release, implicating MEK2 in the activation of the PLA(2) that is involved in IL-1beta-dependent PGE(2) release.	U 0126	13-18	interleukin 1 beta	Homo sapiens	54-62
10903976-0	2000	The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.	Dinoprostone	84-90	interleukin 1 beta	Homo sapiens	65-73
10903976-13	2000	In contrast, UO126 was highly effective at inhibiting IL-1beta-dependent arachidonate release, implicating MEK2 in the activation of the PLA(2) that is involved in IL-1beta-dependent PGE(2) release.	U 0126	13-18	interleukin 1 beta	Homo sapiens	164-172
11091023-16	2000	Among the cytokines, IL-1beta, IL-6, and TNFalpha were the predominant cytokines affected by chronic use of alcohol during pregnancy.	Alcohols	108-115	interleukin 1 beta	Homo sapiens	21-29
10903976-13	2000	In contrast, UO126 was highly effective at inhibiting IL-1beta-dependent arachidonate release, implicating MEK2 in the activation of the PLA(2) that is involved in IL-1beta-dependent PGE(2) release.	Arachidonic Acid	73-85	interleukin 1 beta	Homo sapiens	54-62
11091023-20	2000	We conclude that chronic alcohol use during pregnancy stimulated the fetal cytokine synthesis and secretion, and IL-1beta, IL-6, and TNF alpha were the predominant cytokines affected by alcohol.	Alcohols	186-193	interleukin 1 beta	Homo sapiens	113-121
10903976-13	2000	In contrast, UO126 was highly effective at inhibiting IL-1beta-dependent arachidonate release, implicating MEK2 in the activation of the PLA(2) that is involved in IL-1beta-dependent PGE(2) release.	Arachidonic Acid	73-85	interleukin 1 beta	Homo sapiens	164-172
10903976-13	2000	In contrast, UO126 was highly effective at inhibiting IL-1beta-dependent arachidonate release, implicating MEK2 in the activation of the PLA(2) that is involved in IL-1beta-dependent PGE(2) release.	Prostaglandins E	183-186	interleukin 1 beta	Homo sapiens	54-62
10903976-13	2000	In contrast, UO126 was highly effective at inhibiting IL-1beta-dependent arachidonate release, implicating MEK2 in the activation of the PLA(2) that is involved in IL-1beta-dependent PGE(2) release.	Prostaglandins E	183-186	interleukin 1 beta	Homo sapiens	164-172
10882695-2	2000	Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA.	grepafloxacin	0-13	interleukin 1 beta	Homo sapiens	87-95
10813749-0	2000	Influence of dental amalgam and heavy metal cations on in vitro interleukin-1beta production by human peripheral blood mononuclear cells.	Metals	38-43	interleukin 1 beta	Homo sapiens	64-81
10882695-2	2000	Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA.	grepafloxacin	0-13	interleukin 1 beta	Homo sapiens	130-138
10813749-4	2000	Among other heavy metal cations, Au(3+), Pt(4+), Ni(2+), Pd(2+), but not Ga(3+) or Sn(2+), inhibited IL-1beta production in a concentration-dependent manner.	Metals	18-23	interleukin 1 beta	Homo sapiens	101-109
10813749-9	2000	Our data show that IL-1beta production is altered at protein and mRNA levels by components released from fresh amalgam and by other heavy metal cations, suggesting a role of these cations in changes in the cell phenotype and IL-1-mediated cell functions.	Metals	138-143	interleukin 1 beta	Homo sapiens	19-27
10813749-9	2000	Our data show that IL-1beta production is altered at protein and mRNA levels by components released from fresh amalgam and by other heavy metal cations, suggesting a role of these cations in changes in the cell phenotype and IL-1-mediated cell functions.	Metals	138-143	interleukin 1 beta	Homo sapiens	19-23
10871649-4	2000	The IL-1beta-induced MCP-1 expression was even higher following pretreatment of cells with both oestradiol (10(-9) mol/l) and progesterone (5x10(-8) mol/l).	Estradiol	96-106	interleukin 1 beta	Homo sapiens	4-12
11005265-0	2000	Evidence for a positive correlation between serum cortisol levels and IL-1beta production by peripheral mononuclear cells in anorexia nervosa.	Hydrocortisone	50-58	interleukin 1 beta	Homo sapiens	70-78
10813749-4	2000	Among other heavy metal cations, Au(3+), Pt(4+), Ni(2+), Pd(2+), but not Ga(3+) or Sn(2+), inhibited IL-1beta production in a concentration-dependent manner.	Gold	33-35	interleukin 1 beta	Homo sapiens	101-109
10813749-4	2000	Among other heavy metal cations, Au(3+), Pt(4+), Ni(2+), Pd(2+), but not Ga(3+) or Sn(2+), inhibited IL-1beta production in a concentration-dependent manner.	Platinum	41-43	interleukin 1 beta	Homo sapiens	101-109
10813749-4	2000	Among other heavy metal cations, Au(3+), Pt(4+), Ni(2+), Pd(2+), but not Ga(3+) or Sn(2+), inhibited IL-1beta production in a concentration-dependent manner.	Palladium	57-59	interleukin 1 beta	Homo sapiens	101-109
10861084-4	2000	Low magnitude CTS suppresses IL-1 beta-induced mRNA expression of multiple proteins involved in catabolic responses, such as inducible NO synthase, cyclo-oxygenase II, and collagenase.	castanospermine	14-17	interleukin 1 beta	Homo sapiens	29-38
10861084-5	2000	CTS also counteracts cartilage degradation by augmenting mRNA expression for tissue inhibitor of metalloproteases and collagen type II that are inhibited by IL-1 beta.	castanospermine	0-3	interleukin 1 beta	Homo sapiens	157-166
10908155-4	2000	Lovastatin and simvastatin caused a dose-dependent inhibition of MCP-1 production in peripheral blood mononuclear cells exposed to lipopolysaccharide or inactivated Streptococcus hemoliticus and in human endothelial cells exposed to interleukin-1beta.	Lovastatin	0-10	interleukin 1 beta	Homo sapiens	233-250
10908155-4	2000	Lovastatin and simvastatin caused a dose-dependent inhibition of MCP-1 production in peripheral blood mononuclear cells exposed to lipopolysaccharide or inactivated Streptococcus hemoliticus and in human endothelial cells exposed to interleukin-1beta.	Simvastatin	15-26	interleukin 1 beta	Homo sapiens	233-250
10871649-4	2000	The IL-1beta-induced MCP-1 expression was even higher following pretreatment of cells with both oestradiol (10(-9) mol/l) and progesterone (5x10(-8) mol/l).	Progesterone	126-138	interleukin 1 beta	Homo sapiens	4-12
10825337-1	2000	UNLABELLED: We investigated the hypothesis that oral clonidine premedication would decrease the release of proinflammatory cytokines interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha, and stress hormones cortisol and adrenocorticotropic hormone (ACTH), in patients who underwent total abdominal hysterectomy.	Clonidine	53-62	interleukin 1 beta	Homo sapiens	153-161
10845922-6	2000	On the other hand, inhibition of p38 by SB203580 indicates that this MAPK is involved in the control of IL-1beta production at both transcriptional and translational levels.	SB 203580	40-48	interleukin 1 beta	Homo sapiens	104-112
10833420-2	2000	K-7174 inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either tumor necrosis factor alpha or interleukin-1beta, without affecting the induction of intercellular adhesion molecule-1 or E-selectin.	K 7174	0-6	interleukin 1 beta	Homo sapiens	127-144
10844120-2	2000	The interleukin-1 beta-induced [3H]des-Arg(10)-kallidin binding sites were functional receptors, as bradykinin B(1) receptor agonist-induced responses increased in treated cells.	Tritium	32-34	interleukin 1 beta	Homo sapiens	4-22
10844120-2	2000	The interleukin-1 beta-induced [3H]des-Arg(10)-kallidin binding sites were functional receptors, as bradykinin B(1) receptor agonist-induced responses increased in treated cells.	des-arg	35-42	interleukin 1 beta	Homo sapiens	4-22
10844120-5	2000	Cycloheximide prevented interleukin-1 beta-mediated increases in B(1) and B(2) binding, but not mRNA suggesting that de novo synthesis of a transcriptional activator was unnecessary.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	24-42
10856518-11	2000	While other carotenoids were ineffective, lycopene attenuated both IL-1beta-stimulated and spontaneous HAEC adhesion to U937 monocytic cells by 20 and 25%, respectively.	Lycopene	42-50	interleukin 1 beta	Homo sapiens	67-75
10903882-8	2000	Conclusions These in vitro studies confirm the protective role of CS, which counteracts the IL-1beta induced effects and they confirm the importance of pressure on chondrocyte metabolism and morphology.	Chondroitin Sulfates	66-68	interleukin 1 beta	Homo sapiens	92-100
10845922-5	2000	U0126, a potent inhibitor of the upstream activator of ERK1/2, ie, MEK1/2, suppresses IL-1beta messenger RNA (mRNA) expression in a dose-dependent fashion, showing the implication of this pathway in the transcriptional control of IL-1beta production.	U 0126	0-5	interleukin 1 beta	Homo sapiens	86-94
10845922-5	2000	U0126, a potent inhibitor of the upstream activator of ERK1/2, ie, MEK1/2, suppresses IL-1beta messenger RNA (mRNA) expression in a dose-dependent fashion, showing the implication of this pathway in the transcriptional control of IL-1beta production.	U 0126	0-5	interleukin 1 beta	Homo sapiens	230-238
10861792-5	2000	Our results indicate that exposure of pial and cerebral vasculature to IL-1 beta significantly accelerates recruitment of neutrophils, reduces cerebral blood flow, and increases superoxide anion concentration at the pial surface during reperfusion.	Superoxides	178-194	interleukin 1 beta	Homo sapiens	71-80
10861792-6	2000	These results support the idea that prior exposure of brain vasculature to IL-1 beta results in acceleration of cerebrovascular injury by accelerating recruitment of neutrophils, which secrete superoxide anion, during reperfusion.	Superoxides	193-209	interleukin 1 beta	Homo sapiens	75-84
10825337-6	2000	In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels.	Clonidine	194-203	interleukin 1 beta	Homo sapiens	157-165
10827005-0	2000	Peroxynitrite production by TNF-alpha and IL-1beta: implication for suppression of osteoblastic differentiation.	Peroxynitrous Acid	0-13	interleukin 1 beta	Homo sapiens	42-50
10827005-5	2000	Furthermore, treatment with a combination of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was found to yield ONOO(-) as well as NO and O(-2).	onoo	167-171	interleukin 1 beta	Homo sapiens	119-136
10825337-6	2000	In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels.	Clonidine	58-67	interleukin 1 beta	Homo sapiens	157-165
10827005-5	2000	Furthermore, treatment with a combination of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was found to yield ONOO(-) as well as NO and O(-2).	onoo	167-171	interleukin 1 beta	Homo sapiens	138-146
10827005-7	2000	We conclude that ONOO(-) produced by TNF-alpha and IL-1beta, but not NO per se, would overcome the stimulatory effect of NO on osteoblastic activity and inhibit osteoblastic differentiation.	onoo	17-21	interleukin 1 beta	Homo sapiens	51-59
10843735-1	2000	Interleukin (IL-)1 stimulates prostaglandin E(2)(PGE(2)) generation in fibroblasts, and preferential couplings between particular phospholipase A(2)(PLA(2)) and cyclooxygenase (COX) isozymes are implicated with IL-1-induced delayed PGE(2)generation.	Prostaglandins E	232-235	interleukin 1 beta	Homo sapiens	0-18
10843735-1	2000	Interleukin (IL-)1 stimulates prostaglandin E(2)(PGE(2)) generation in fibroblasts, and preferential couplings between particular phospholipase A(2)(PLA(2)) and cyclooxygenase (COX) isozymes are implicated with IL-1-induced delayed PGE(2)generation.	Dinoprostone	30-48	interleukin 1 beta	Homo sapiens	0-18
10843735-1	2000	Interleukin (IL-)1 stimulates prostaglandin E(2)(PGE(2)) generation in fibroblasts, and preferential couplings between particular phospholipase A(2)(PLA(2)) and cyclooxygenase (COX) isozymes are implicated with IL-1-induced delayed PGE(2)generation.	Prostaglandins E	49-52	interleukin 1 beta	Homo sapiens	0-18
10843735-3	2000	These human fibroblasts constitutively expressed cytosolic PLA(2)(cPLA(2)) and COX-1 enzymes, and exhibited delayed PGE(2)generation in response to IL-1beta.	Prostaglandins E	116-119	interleukin 1 beta	Homo sapiens	148-156
10843735-5	2000	A COX-2 inhibitor and cPLA(2)inhibitor markedly suppressed the IL-1beta-induced delayed PGE(2)generation, while a type IIA sPLA(2)inhibitor failed to affect it.	Prostaglandins E	88-91	interleukin 1 beta	Homo sapiens	63-71
10843735-6	2000	IFN-gamma and IL-4 dramatically inhibited the IL-1beta-induced delayed PGE(2)generation; these cytokines apparently suppressed IL-1beta-stimulated COX-2 expression and only weakly suppressed cPLA(2)expression in response to IL-1beta.	Prostaglandins E	71-74	interleukin 1 beta	Homo sapiens	46-54
10843735-7	2000	These results indicate that IL-1beta-induced delayed PGE(2)generation in these human fibroblasts mainly depends on de novo induction of COX-2 and cPLA(2), irrespective of the constitutive presence of COX-1, and that IFN-gamma and IL-4 inhibit IL-1beta-induced delayed PGE(2)generation by suppressing, predominantly, COX-2 expression.	Prostaglandins E	53-56	interleukin 1 beta	Homo sapiens	28-36
10903798-7	2000	Fifteen pg/ml of recombinant human (rh) IL-1 beta as well as 200 U/ml recombinant rat (rr) IFN-gamma + 250 U/ml rhTNF-alpha significantly increased islet NO production and inhibited both accumulated and glucose-challenged islet insulin release.	Glucose	203-210	interleukin 1 beta	Homo sapiens	40-49
10843735-7	2000	These results indicate that IL-1beta-induced delayed PGE(2)generation in these human fibroblasts mainly depends on de novo induction of COX-2 and cPLA(2), irrespective of the constitutive presence of COX-1, and that IFN-gamma and IL-4 inhibit IL-1beta-induced delayed PGE(2)generation by suppressing, predominantly, COX-2 expression.	Prostaglandins E	268-271	interleukin 1 beta	Homo sapiens	28-36
10852253-0	2000	Interleukin-1beta induces elevation of spermidine/spermine N1-acetyltransferase activity and an increase in the amount of putrescine in synovial adherent cells from patients with rheumatoid arthritis.	Putrescine	122-132	interleukin 1 beta	Homo sapiens	0-17
10836722-6	2000	Amlodipine, but not nifedipine, significantly decreased MMP-1 levels in IL-1beta-stimulated ECs.	Amlodipine	0-10	interleukin 1 beta	Homo sapiens	72-80
10836722-8	2000	Amlodipine significantly inhibited collagenolytic activity in the culture media of IL-1beta-stimulated ECs, whereas nifedipine showed no significant effect on the activity.	Amlodipine	0-10	interleukin 1 beta	Homo sapiens	83-91
10836722-9	2000	Our findings revealed that amlodipine, but not nifedipine, inhibits IL-1beta-induced MMP-1 expression in human ECs.	Amlodipine	27-37	interleukin 1 beta	Homo sapiens	68-76
10873029-4	2000	METHODS: Hyaluronan deposited in the medium of untreated fibroblasts or fibroblasts treated with either IL-1beta or TNF-alpha was determined by an assay utilizing iodine I 125-hyaluronan binding protein.	Hyaluronic Acid	9-19	interleukin 1 beta	Homo sapiens	104-112
10873029-4	2000	METHODS: Hyaluronan deposited in the medium of untreated fibroblasts or fibroblasts treated with either IL-1beta or TNF-alpha was determined by an assay utilizing iodine I 125-hyaluronan binding protein.	Iodine-125	163-175	interleukin 1 beta	Homo sapiens	104-112
10873029-4	2000	METHODS: Hyaluronan deposited in the medium of untreated fibroblasts or fibroblasts treated with either IL-1beta or TNF-alpha was determined by an assay utilizing iodine I 125-hyaluronan binding protein.	Hyaluronic Acid	176-186	interleukin 1 beta	Homo sapiens	104-112
10873029-6	2000	RESULTS: IL-1beta induced an increase in hyaluronan accumulation by both fetal and adult fibroblasts.	Hyaluronic Acid	41-51	interleukin 1 beta	Homo sapiens	9-17
10862535-3	2000	The aim of this study was to determine whether the increased histamine release in highly trained athletes is related to a high plasma level in interleukin-1 beta (IL-1beta), IL-3, or IL-8 in arterial blood.	Histamine	61-70	interleukin 1 beta	Homo sapiens	143-161
10862535-3	2000	The aim of this study was to determine whether the increased histamine release in highly trained athletes is related to a high plasma level in interleukin-1 beta (IL-1beta), IL-3, or IL-8 in arterial blood.	Histamine	61-70	interleukin 1 beta	Homo sapiens	163-171
10942208-3	2000	Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 (PGE2) release in human gingival fibroblasts (HGF), here we analyzed the effect of IL-1beta on the expression of COX-2 and the activation of NFkappaB in HGF.	Dinoprostone	66-82	interleukin 1 beta	Homo sapiens	32-40
10942208-3	2000	Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 (PGE2) release in human gingival fibroblasts (HGF), here we analyzed the effect of IL-1beta on the expression of COX-2 and the activation of NFkappaB in HGF.	Dinoprostone	66-82	interleukin 1 beta	Homo sapiens	166-174
10942208-3	2000	Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 (PGE2) release in human gingival fibroblasts (HGF), here we analyzed the effect of IL-1beta on the expression of COX-2 and the activation of NFkappaB in HGF.	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	32-40
10942208-5	2000	The effect of IL-1beta was abrogated by herbimycin A, a protein tyrosine kinase inhibitor, and enhanced by orthovanadate, a protein tyrosine phosphatase inhibitor.	herbimycin	40-52	interleukin 1 beta	Homo sapiens	14-22
10942208-5	2000	The effect of IL-1beta was abrogated by herbimycin A, a protein tyrosine kinase inhibitor, and enhanced by orthovanadate, a protein tyrosine phosphatase inhibitor.	Vanadates	107-120	interleukin 1 beta	Homo sapiens	14-22
10942208-6	2000	IL-1beta-induced PGE2 release was blocked by the tyrosine kinase inhibitor and increased by the tyrosine phosphatase inhibitor.	Dinoprostone	17-21	interleukin 1 beta	Homo sapiens	0-8
10942208-8	2000	Gel mobility shift assays with a radiolabelled COX-2-NFkappaB oligonucleotide (nts-223 to-214) revealed an increase in the binding of nuclear proteins from IL-1beta-stimulated HGF.	Oligonucleotides	62-77	interleukin 1 beta	Homo sapiens	156-164
10942208-9	2000	This increase of DNA-protein complex formation induced by IL-1beta was blocked by herbimycin A and another tyrosine kinase inhibitor, genistein.	herbimycin	82-94	interleukin 1 beta	Homo sapiens	58-66
10942208-9	2000	This increase of DNA-protein complex formation induced by IL-1beta was blocked by herbimycin A and another tyrosine kinase inhibitor, genistein.	Genistein	134-143	interleukin 1 beta	Homo sapiens	58-66
10942208-10	2000	These results suggest that NFkappaB is an important transcription factor for IL-1beta-induced COX-2 gene expression, and is involved in inducing COX-2 gene transcription through tyrosine phosphorylation in HGF.	Tyrosine	178-186	interleukin 1 beta	Homo sapiens	77-85
10935448-5	2000	In contrast, beta-catenin protein levels were reduced markedly in NTera2-N cells by exposure to dbcAMP, EGF or bFGF, and in U-373MG cells by treatment with dbcAMP or PMA, but were unaffected in any cell lines by BDNF, TNF-alpha, IL-1beta, IL-6, IFN-gamma or TGF-beta1.	Bucladesine	156-162	interleukin 1 beta	Homo sapiens	229-237
12515149-0	2000	[The change in placental estradiol-progesterone ratio and its relationship with the fetal membrane"s response to IL-1 beta in labor].	Estradiol	25-34	interleukin 1 beta	Homo sapiens	113-122
12515149-0	2000	[The change in placental estradiol-progesterone ratio and its relationship with the fetal membrane"s response to IL-1 beta in labor].	Progesterone	35-47	interleukin 1 beta	Homo sapiens	113-122
12515149-1	2000	This study was designed to investigate the local changes in the levels of placental estradiol and progesterone and their ratio during term labor and to determine whether the PGE2-generating ability of the fetal membrane in response to IL-1 beta at term labor is greater than that at term not-in-labor.	Dinoprostone	174-178	interleukin 1 beta	Homo sapiens	235-244
12515149-6	2000	IL-1 beta stimulated fetal membrane to produce more PGE2 at term labor, and at term not-in-labor, too.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	0-9
10894180-8	2000	Pretreatment of FHAS with 10 micromol/L dexamethasone inhibited both hypoxia-induced expression/secretion of IL-1beta and the ability of hypoxic ACM to induce inflammatory phenotype in HCECs.	Dexamethasone	40-53	interleukin 1 beta	Homo sapiens	109-117
10844583-5	2000	Postoperatively, on the day of surgery, ACTH and cortisol concentrations in group 1 patients were positively correlated to the blood concentrations of IL-1beta, IL-6 and TNF-alpha.	Hydrocortisone	49-57	interleukin 1 beta	Homo sapiens	151-159
10925209-5	2000	The thiol antioxidant, N-acetylcysteine (NAC) abolished the synergism between IL-1beta or IL-6 and 1,25(OH)(2)D(3), but had only a small protective effect when the cytokines acted alone.	Sulfhydryl Compounds	4-9	interleukin 1 beta	Homo sapiens	78-86
10925209-5	2000	The thiol antioxidant, N-acetylcysteine (NAC) abolished the synergism between IL-1beta or IL-6 and 1,25(OH)(2)D(3), but had only a small protective effect when the cytokines acted alone.	Acetylcysteine	23-39	interleukin 1 beta	Homo sapiens	78-86
10825375-2	2000	Cytokines, e.g. interleukin 1 beta (IL-1beta), are up-regulated in the amniotic fluid late in gestation and can increase prostaglandin production through the expression of cyclo-oxygenase 2 (COX-2), the prostaglandin synthetic isoform involved in human labour.	Prostaglandins	121-134	interleukin 1 beta	Homo sapiens	16-34
10825375-2	2000	Cytokines, e.g. interleukin 1 beta (IL-1beta), are up-regulated in the amniotic fluid late in gestation and can increase prostaglandin production through the expression of cyclo-oxygenase 2 (COX-2), the prostaglandin synthetic isoform involved in human labour.	Prostaglandins	121-134	interleukin 1 beta	Homo sapiens	36-44
10825375-2	2000	Cytokines, e.g. interleukin 1 beta (IL-1beta), are up-regulated in the amniotic fluid late in gestation and can increase prostaglandin production through the expression of cyclo-oxygenase 2 (COX-2), the prostaglandin synthetic isoform involved in human labour.	Prostaglandins	203-216	interleukin 1 beta	Homo sapiens	16-34
10825375-2	2000	Cytokines, e.g. interleukin 1 beta (IL-1beta), are up-regulated in the amniotic fluid late in gestation and can increase prostaglandin production through the expression of cyclo-oxygenase 2 (COX-2), the prostaglandin synthetic isoform involved in human labour.	Prostaglandins	203-216	interleukin 1 beta	Homo sapiens	36-44
10825382-3	2000	TNF-alpha and IL-1beta both induced a rapid and transient increase in B1 and B2 receptor mRNA expression that was maximal by 2 h, accompanied by an increase in B1 and B2 receptor protein, as measured by radioligand binding assay with [(3)H]des-Arg(10)-kallidin, and [(3)H]bradykinin, respectively.	des-arg	240-247	interleukin 1 beta	Homo sapiens	14-22
10825382-6	2000	TNF-alpha and IL-1beta regulation of both B1 and B2 receptors was inhibited by dexamethasone.	Dexamethasone	79-92	interleukin 1 beta	Homo sapiens	14-22
10788757-0	2000	Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations.	monoamine	98-107	interleukin 1 beta	Homo sapiens	23-40
10788757-5	2000	Although IL-1beta and TNF-alpha provoked variations of amine turnover in the hypothalamus, locus coeruleus, and central amygdala, synergistic effects were not evident in this respect.	Amines	55-60	interleukin 1 beta	Homo sapiens	9-17
10867521-4	2000	As assessed by Western immunoblotting, incubation of MC in vitro with tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) caused a time-dependent induction of HSP 72/73 expression, which was maximal 6 h after stimulation.	Methylcholanthrene	53-55	interleukin 1 beta	Homo sapiens	114-131
10867521-4	2000	As assessed by Western immunoblotting, incubation of MC in vitro with tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) caused a time-dependent induction of HSP 72/73 expression, which was maximal 6 h after stimulation.	Methylcholanthrene	53-55	interleukin 1 beta	Homo sapiens	133-141
10867521-5	2000	We suggest that the increased HSP 72/73 expression of MC during peritonitis is in part induced by TNF-alpha and IL-1beta and may exert a cell-protective function, lessening MC damage during peritonitis.	Methylcholanthrene	54-56	interleukin 1 beta	Homo sapiens	112-120
10894105-9	2000	RESULTS: Pre-incubation with TNF-alpha and IL-1beta caused a significant leftward shift, and an increase in the magnitude, of the concentration-response curves to both ACh and NKA.	Acetylcholine	168-171	interleukin 1 beta	Homo sapiens	43-51
10913230-3	2000	The incubation of HPASMC with various concentrations of LPS, IL-1(beta)or TNF(alpha)for 24 h caused a significant increase in nitrite release and PGI(2)production.	Nitrites	126-133	interleukin 1 beta	Homo sapiens	61-71
10913230-3	2000	The incubation of HPASMC with various concentrations of LPS, IL-1(beta)or TNF(alpha)for 24 h caused a significant increase in nitrite release and PGI(2)production.	Epoprostenol	146-152	interleukin 1 beta	Homo sapiens	61-71
10913230-7	2000	Addition of L-NMMA to a medium containing LPS or IL-1(beta)reduced nitrite release and attenuated the stimulatory effect of those agents on PGI(2)production.	omega-N-Methylarginine	12-18	interleukin 1 beta	Homo sapiens	49-59
10913230-7	2000	Addition of L-NMMA to a medium containing LPS or IL-1(beta)reduced nitrite release and attenuated the stimulatory effect of those agents on PGI(2)production.	Nitrites	67-74	interleukin 1 beta	Homo sapiens	49-59
10913230-7	2000	Addition of L-NMMA to a medium containing LPS or IL-1(beta)reduced nitrite release and attenuated the stimulatory effect of those agents on PGI(2)production.	Epoprostenol	140-146	interleukin 1 beta	Homo sapiens	49-59
10852253-1	2000	OBJECTIVE: To investigate polyamine metabolism in rheumatoid synovial adherent cells stimulated by interleukin- 1beta (IL-1beta).	Polyamines	26-35	interleukin 1 beta	Homo sapiens	99-117
10852253-1	2000	OBJECTIVE: To investigate polyamine metabolism in rheumatoid synovial adherent cells stimulated by interleukin- 1beta (IL-1beta).	Polyamines	26-35	interleukin 1 beta	Homo sapiens	119-127
10852253-6	2000	Spermine and N8-acetylspermidine in synovial adherent cells incubated with IL-1beta decreased significantly more than in synovial adherent cells incubated without.	Spermine	0-8	interleukin 1 beta	Homo sapiens	75-83
10852253-6	2000	Spermine and N8-acetylspermidine in synovial adherent cells incubated with IL-1beta decreased significantly more than in synovial adherent cells incubated without.	N(8)-acetylspermidine	13-32	interleukin 1 beta	Homo sapiens	75-83
10852253-9	2000	CONCLUSION: An increase in the putrescine level in rheumatoid synovial adherent cells as a result of the elevation of SAT activity induced by IL-1beta may play a role in RA.	Putrescine	31-41	interleukin 1 beta	Homo sapiens	142-150
10788422-5	2000	Here we show that 16K-PRL, but not full-length PRL, acts to promote the expression of the inducible isoform of nitric oxide synthase (iNOS) and nitric oxide (*NO) production by pulmonary fibroblasts and alveolar type II cells with potency comparable with the proinflammatory cytokines interleukin-1beta, interferon gamma, and tumor necrosis factor alpha.	Nitric Oxide	111-123	interleukin 1 beta	Homo sapiens	285-302
10806325-3	2000	IL-1beta secretion is observed only following concomitant stimulation with 1000 units/ml of IL-1beta and 20 mM ATP.	Adenosine Triphosphate	111-114	interleukin 1 beta	Homo sapiens	0-8
10806325-5	2000	Our data, together with the observation that the depolarizing effects of ATP are retained after preincubation with 100 microM suramin, an antagonist of P2-purinoceptors, suggest that ATP plays a role in IL-1beta secretion by T98G but its effects do not occur through P2-purinoceptors.	Adenosine Triphosphate	73-76	interleukin 1 beta	Homo sapiens	203-211
10806325-5	2000	Our data, together with the observation that the depolarizing effects of ATP are retained after preincubation with 100 microM suramin, an antagonist of P2-purinoceptors, suggest that ATP plays a role in IL-1beta secretion by T98G but its effects do not occur through P2-purinoceptors.	Suramin	126-133	interleukin 1 beta	Homo sapiens	203-211
10806325-5	2000	Our data, together with the observation that the depolarizing effects of ATP are retained after preincubation with 100 microM suramin, an antagonist of P2-purinoceptors, suggest that ATP plays a role in IL-1beta secretion by T98G but its effects do not occur through P2-purinoceptors.	Adenosine Triphosphate	183-186	interleukin 1 beta	Homo sapiens	203-211
10799869-3	2000	Both maturation of IL-1 beta and formation of glycerophosphocholine were blocked by bromoenol lactone, the specific iPLA2 inhibitor.	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	84-101	interleukin 1 beta	Homo sapiens	19-28
10799869-4	2000	Bromoenol lactone-dependent inhibition of IL-1 beta processing was not due to perturbation of the export machinery for pro-IL-1 beta and IL-1 beta or to caspase-1 suppression.	bromoenol	0-9	interleukin 1 beta	Homo sapiens	42-51
10799869-4	2000	Bromoenol lactone-dependent inhibition of IL-1 beta processing was not due to perturbation of the export machinery for pro-IL-1 beta and IL-1 beta or to caspase-1 suppression.	Lactones	10-17	interleukin 1 beta	Homo sapiens	42-51
10828965-1	2000	We have synthesized (acyloxy)methyl ketone inactivators of papain, cathepsin B, and interleukin-1beta conversion enzyme (ICE) that interact with both the S and S" subsites.	(acyloxy)methyl ketone	20-42	interleukin 1 beta	Homo sapiens	84-101
10839541-7	2000	Acetylcholine, the principle vagal neurotransmitter, significantly attenuated the release of cytokines (tumour necrosis factor (TNF), interleukin (IL)-1beta, IL-6 and IL-18), but not the anti-inflammatory cytokine IL-10, in lipopolysaccharide-stimulated human macrophage cultures.	Acetylcholine	0-13	interleukin 1 beta	Homo sapiens	134-156
10799869-0	2000	Potassium regulates IL-1 beta processing via calcium-independent phospholipase A2.	Calcium	45-52	interleukin 1 beta	Homo sapiens	20-29
10799869-1	2000	We report that potassium leakage from cells leads to activation of the Ca2+-independent phospholipase A2 (iPLA2), and the latter plays a pivotal role in regulating the cleavage of pro-IL-1 beta by the IL-converting enzyme caspase-1 in human monocytes.	Potassium	15-24	interleukin 1 beta	Homo sapiens	180-193
10801753-4	2000	L-Arginine, the principal substrate for nitric oxide synthases, added to the media suppressed the induction of TF activity significantly (by 66% for lipopolysaccharide induction and by 59% for interleukin-1beta induction) at 24 hours.	Arginine	0-10	interleukin 1 beta	Homo sapiens	193-210
10788433-3	2000	In C6 glioma cells, tumor necrosis factor-alpha (TNF-alpha) concomitantly potentiated the stimulation of nitric oxide (NO) and BH(4) production induced by IFN-gamma and interleukin-1beta.	Nitric Oxide	105-117	interleukin 1 beta	Homo sapiens	169-186
10812056-0	2000	Bradykinin potentiates prostaglandin E(2) release in the human gingival fibroblasts pretreated with interleukin-1beta via Ca(2+) mobilization.	Dinoprostone	23-41	interleukin 1 beta	Homo sapiens	100-117
10812056-1	2000	Interleukin-1beta, a proinflammatory cytokine, causes a slow increase in prostaglandin E(2) release.	Dinoprostone	73-91	interleukin 1 beta	Homo sapiens	0-17
10812056-7	2000	In the fibroblasts pretreated with interleukin-1beta, Ca(2+)-mobilizing reagents such as ionomycin and thapsigargin mimicked the potentiating effect of bradykinin on prostaglandin E(2) release.	Thapsigargin	103-115	interleukin 1 beta	Homo sapiens	35-52
10812056-3	2000	Simultaneous stimulation with interleukin-1beta (200 pg/ml) and bradykinin (1 microM) evoked a moderately synergistic increase in prostaglandin E(2) release in human gingival fibroblasts.	Dinoprostone	130-148	interleukin 1 beta	Homo sapiens	30-47
10812056-4	2000	However, in the human gingival fibroblasts pretreated with interleukin-1beta, bradykinin drastically enhanced prostaglandin E(2) release.	Dinoprostone	110-128	interleukin 1 beta	Homo sapiens	59-76
10812056-5	2000	NS-398, a specific inhibitor of cyclooxygenase-2, inhibited not only interleukin-1beta-induced prostaglandin E(2) release but also bradykinin-induced prostaglandin E(2) release in the human gingival fibroblasts pretreated with interleukin-1beta.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	69-86
10812056-7	2000	In the fibroblasts pretreated with interleukin-1beta, Ca(2+)-mobilizing reagents such as ionomycin and thapsigargin mimicked the potentiating effect of bradykinin on prostaglandin E(2) release.	prostaglandin e(2) release	166-192	interleukin 1 beta	Homo sapiens	35-52
10812056-5	2000	NS-398, a specific inhibitor of cyclooxygenase-2, inhibited not only interleukin-1beta-induced prostaglandin E(2) release but also bradykinin-induced prostaglandin E(2) release in the human gingival fibroblasts pretreated with interleukin-1beta.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	227-244
10812056-8	2000	These results suggest that interleukin-1beta- and bradykinin-induced prostaglandin E(2) release is dependent on cyclooxygenase-2 and the potentiated effect of bradykinin in the human gingival fibroblasts primed with interleukin-1beta is caused by Ca(2+) mobilization.	Dinoprostone	69-87	interleukin 1 beta	Homo sapiens	27-44
10812056-5	2000	NS-398, a specific inhibitor of cyclooxygenase-2, inhibited not only interleukin-1beta-induced prostaglandin E(2) release but also bradykinin-induced prostaglandin E(2) release in the human gingival fibroblasts pretreated with interleukin-1beta.	Prostaglandins E	95-110	interleukin 1 beta	Homo sapiens	69-86
10812056-6	2000	Transcriptional and translational inhibitors such as actinomycin D, cycloheximide, and dexamethasone also suppressed the interleukin-1beta-induced prostaglandin E(2) release and the bradykinin-induced prostaglandin E(2) release in interleukin-1beta-pretreated human gingival fibroblasts.	Dactinomycin	53-66	interleukin 1 beta	Homo sapiens	121-138
10812056-6	2000	Transcriptional and translational inhibitors such as actinomycin D, cycloheximide, and dexamethasone also suppressed the interleukin-1beta-induced prostaglandin E(2) release and the bradykinin-induced prostaglandin E(2) release in interleukin-1beta-pretreated human gingival fibroblasts.	Dactinomycin	53-66	interleukin 1 beta	Homo sapiens	231-248
10812056-6	2000	Transcriptional and translational inhibitors such as actinomycin D, cycloheximide, and dexamethasone also suppressed the interleukin-1beta-induced prostaglandin E(2) release and the bradykinin-induced prostaglandin E(2) release in interleukin-1beta-pretreated human gingival fibroblasts.	Cycloheximide	68-81	interleukin 1 beta	Homo sapiens	121-138
10812056-6	2000	Transcriptional and translational inhibitors such as actinomycin D, cycloheximide, and dexamethasone also suppressed the interleukin-1beta-induced prostaglandin E(2) release and the bradykinin-induced prostaglandin E(2) release in interleukin-1beta-pretreated human gingival fibroblasts.	Cycloheximide	68-81	interleukin 1 beta	Homo sapiens	231-248
10812056-6	2000	Transcriptional and translational inhibitors such as actinomycin D, cycloheximide, and dexamethasone also suppressed the interleukin-1beta-induced prostaglandin E(2) release and the bradykinin-induced prostaglandin E(2) release in interleukin-1beta-pretreated human gingival fibroblasts.	Dexamethasone	87-100	interleukin 1 beta	Homo sapiens	121-138
10812056-6	2000	Transcriptional and translational inhibitors such as actinomycin D, cycloheximide, and dexamethasone also suppressed the interleukin-1beta-induced prostaglandin E(2) release and the bradykinin-induced prostaglandin E(2) release in interleukin-1beta-pretreated human gingival fibroblasts.	Dexamethasone	87-100	interleukin 1 beta	Homo sapiens	231-248
10812056-6	2000	Transcriptional and translational inhibitors such as actinomycin D, cycloheximide, and dexamethasone also suppressed the interleukin-1beta-induced prostaglandin E(2) release and the bradykinin-induced prostaglandin E(2) release in interleukin-1beta-pretreated human gingival fibroblasts.	Prostaglandins E	147-162	interleukin 1 beta	Homo sapiens	121-138
10812056-6	2000	Transcriptional and translational inhibitors such as actinomycin D, cycloheximide, and dexamethasone also suppressed the interleukin-1beta-induced prostaglandin E(2) release and the bradykinin-induced prostaglandin E(2) release in interleukin-1beta-pretreated human gingival fibroblasts.	Prostaglandins E	147-162	interleukin 1 beta	Homo sapiens	231-248
10812056-7	2000	In the fibroblasts pretreated with interleukin-1beta, Ca(2+)-mobilizing reagents such as ionomycin and thapsigargin mimicked the potentiating effect of bradykinin on prostaglandin E(2) release.	Ionomycin	89-98	interleukin 1 beta	Homo sapiens	35-52
10773646-3	2000	IL-1beta, one of these cytokines, stimulates the production of nitric oxide (NO), a potent inflammatory mediator.	Nitric Oxide	63-75	interleukin 1 beta	Homo sapiens	0-8
10857767-3	2000	Their cell-associated IL-1beta levels are elevated after stimulation with tumour necrosis factor (TNF-)alpha but not with cytokines such as IL-1alpha, IL-3, IL-4, IL-6, IL-7, IL-10, SCF, G-CSF, M-CSF and TGF-beta or lipid mediators such as PGE2, LTB4, LXA4, LXB4, 12-HETE, 15-HETE and PAF.	Dinoprostone	240-244	interleukin 1 beta	Homo sapiens	22-30
10857757-3	2000	The PKC inhibitors chelerythrine and H7 blocked induction of IL-1beta mRNA expression in human PMNs.	chelerythrine	19-32	interleukin 1 beta	Homo sapiens	61-69
10905622-4	2000	Our recent studies indicate the ability of cytokines, e.g., tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta) and interferon-gamma (IFNgamma), to induce the inducible nitric oxide (iNOS) and secretory phospholipase A2 (sPLA2) genes in immortalized astrocytes (DITNC) (Li et al., J. Interferon and Cytokine Res.	Nitric Oxide	186-198	interleukin 1 beta	Homo sapiens	100-117
10857757-6	2000	The intracellular Ca2+ chelator BAPTA/AM inhibited induction of IL1beta mRNA accumulation and transcription by GM-CSF.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	32-37	interleukin 1 beta	Homo sapiens	64-71
10857757-7	2000	At concentrations similar to those used to inhibit IL-1beta gene expression, H7, chelerythrine, and BAPTA all inhibited substrate phosphorylation by PKC isolated from PMN lysates.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	100-105	interleukin 1 beta	Homo sapiens	51-59
10859472-8	2000	When we used MoDCs pretreated with each of these stimulations + Dex or + CyA as APCs, however, significant suppression of T cell proliferation was observed only in the case of the pretreatment with IL-1beta/TNF-alpha + Dex.	Dexamethasone	64-67	interleukin 1 beta	Homo sapiens	198-206
10790428-10	2000	Furthermore, PI-9 antisense oligonucleotides coordinately reduced PI-9 expression and promoted IL-1beta release.	Oligonucleotides	28-44	interleukin 1 beta	Homo sapiens	95-103
10800946-3	2000	The carbachol-induced arachidonate release is potentiated two- to threefold by pretreatment of A2058 cells with either of the inflammatory cytokines, tumor necrosis factor-alpha or interleukin-1beta .	Carbachol	4-13	interleukin 1 beta	Homo sapiens	181-198
10800946-3	2000	The carbachol-induced arachidonate release is potentiated two- to threefold by pretreatment of A2058 cells with either of the inflammatory cytokines, tumor necrosis factor-alpha or interleukin-1beta .	Arachidonic Acid	22-34	interleukin 1 beta	Homo sapiens	181-198
10848817-6	2000	Cells in group B were appropriately primed by G-CSF, GM-CSF, tumour necrosis factor alpha and IL-1beta for enhanced release of O2 -.	Superoxides	127-129	interleukin 1 beta	Homo sapiens	94-102
10872952-8	2000	RESULTS: The IL-1beta +3953 allele "1" was carried by &gt;99% of the AA control population and by 100% of the AA LJP group, with most individuals being homozygous 1,1.	CB 1837	113-116	interleukin 1 beta	Homo sapiens	13-21
10806046-0	2000	Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.	diacerein	0-10	interleukin 1 beta	Homo sapiens	44-52
10905622-4	2000	Our recent studies indicate the ability of cytokines, e.g., tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta) and interferon-gamma (IFNgamma), to induce the inducible nitric oxide (iNOS) and secretory phospholipase A2 (sPLA2) genes in immortalized astrocytes (DITNC) (Li et al., J. Interferon and Cytokine Res.	Nitric Oxide	186-198	interleukin 1 beta	Homo sapiens	119-127
11174072-1	2000	OBJECTIVE: To analyze the gene expression of osteoarthritic chondrocytes cultured in alginate after stimulation with interleukin (IL)-1beta.	Alginates	85-93	interleukin 1 beta	Homo sapiens	117-139
10754324-6	2000	TNF-alpha and IL-1beta, known to be increased in HIV-encephalitic brains, as well as a cellular product of cytokine stimulation, ceramide, were also shown to induce release of cysteine from hMDM in a dose-dependent manner.	Cysteine	176-184	interleukin 1 beta	Homo sapiens	14-22
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Methotrexate	161-164	interleukin 1 beta	Homo sapiens	83-91
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Methotrexate	172-175	interleukin 1 beta	Homo sapiens	83-91
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Methotrexate	179-191	interleukin 1 beta	Homo sapiens	83-91
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	331-356	interleukin 1 beta	Homo sapiens	83-91
10766857-4	2000	Cross-linking and affinity binding studies reveal that IL-1beta exclusively binds the type I receptor (IL-1RI) and not IL-1RII in both HT-29/p and HT-29/MTX cells.	Methotrexate	153-156	interleukin 1 beta	Homo sapiens	55-63
10766857-8	2000	kappaB-luciferase reporter gene activity was 16-fold higher following TNF receptor-associated factor-6 transfection after IL-1beta stimulation in HT-29/MTX cells.	Methotrexate	152-155	interleukin 1 beta	Homo sapiens	122-130
10822373-5	2000	This inhibitory effect of IL-1beta was evident when cells were treated with protein synthesis inhibitors such as cycloheximide (CHX).	Cycloheximide	113-126	interleukin 1 beta	Homo sapiens	26-34
10822373-5	2000	This inhibitory effect of IL-1beta was evident when cells were treated with protein synthesis inhibitors such as cycloheximide (CHX).	Cycloheximide	128-131	interleukin 1 beta	Homo sapiens	26-34
10807407-6	2000	RESULTS: The expression of CD11b and CD18 on neutrophils and neutrophil-dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses, and the expression of ICAM-1 and VCAM-1 on endothelial cells and endothelial-dependent neutrophil adherence induced by IL-1beta were also inhibited by lansoprazole and omeprazole at similar doses.	Lansoprazole	146-158	interleukin 1 beta	Homo sapiens	321-329
10733939-2	2000	Interleukin-1 (IL-1) beta release from M&amp;phi; in response to LPS, appears to be mediated by the autocrine/paracrine release of ATP via P2X7 receptor activation.	Adenosine Monophosphate	41-44	interleukin 1 beta	Homo sapiens	15-25
10733939-2	2000	Interleukin-1 (IL-1) beta release from M&amp;phi; in response to LPS, appears to be mediated by the autocrine/paracrine release of ATP via P2X7 receptor activation.	Adenosine Triphosphate	131-134	interleukin 1 beta	Homo sapiens	15-25
10807407-6	2000	RESULTS: The expression of CD11b and CD18 on neutrophils and neutrophil-dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses, and the expression of ICAM-1 and VCAM-1 on endothelial cells and endothelial-dependent neutrophil adherence induced by IL-1beta were also inhibited by lansoprazole and omeprazole at similar doses.	Omeprazole	163-173	interleukin 1 beta	Homo sapiens	321-329
10768082-4	2000	This substance has been shown to represent low concentrations of TNF-alpha and IL-1 beta acting in synergy on the myocardium through mechanisms that include NO and cGMP generation.	Cyclic GMP	164-168	interleukin 1 beta	Homo sapiens	79-88
11775226-2	2000	METHODS: Interleukin-1 beta (IL-1 beta) and interleukin-1 receptor antagonist (IL-1Ra) produced by cultured peripheral blood mononuclear cells (PBMC) after exposure to cuprammonium (Cup) membrane, polysulfone (PS) membranes or endotoxin were detected using enzyme-linked immunoabsorbent assay.	cuprammonium	168-180	interleukin 1 beta	Homo sapiens	9-27
11775226-2	2000	METHODS: Interleukin-1 beta (IL-1 beta) and interleukin-1 receptor antagonist (IL-1Ra) produced by cultured peripheral blood mononuclear cells (PBMC) after exposure to cuprammonium (Cup) membrane, polysulfone (PS) membranes or endotoxin were detected using enzyme-linked immunoabsorbent assay.	cuprammonium	168-180	interleukin 1 beta	Homo sapiens	29-38
10858012-4	2000	RESULTS: In response to IL-1beta and TNF-alpha combined cells of the thyroid epithelial cell line Nthy-ori3-1 secreted marked amounts of PGE2 in a time-dependent fashion.	Dinoprostone	137-141	interleukin 1 beta	Homo sapiens	24-32
10938736-8	2000	Both SA-elicited and SG-elicited PC expressed higher amounts of IL-1 beta and SAA mRNA compared to saline-injected fish HKC and PC, indicating that these proteins are associated with inflammatory responses, similar to mammalian homologues.	Alginates	5-7	interleukin 1 beta	Homo sapiens	64-73
10722595-4	2000	Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS).	Anisomycin	183-193	interleukin 1 beta	Homo sapiens	43-47
10722595-4	2000	Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS).	pimagedine	227-241	interleukin 1 beta	Homo sapiens	43-47
10722595-4	2000	Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS).	Dexamethasone	302-315	interleukin 1 beta	Homo sapiens	43-47
10699967-1	2000	We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A.	2-(methylamino)isobutyric acid	79-114	interleukin 1 beta	Homo sapiens	37-54
10644962-0	2000	Proinflammatory cytokine expression of IL-1beta and TNF-alpha by human osteoblast-like MG-63 cells upon exposure to silicon nitride in vitro.	silicon nitride	116-131	interleukin 1 beta	Homo sapiens	39-47
10699967-1	2000	We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A.	2-(methylamino)isobutyric acid	79-114	interleukin 1 beta	Homo sapiens	56-64
10699967-1	2000	We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A.	2-(methylamino)isobutyric acid	116-121	interleukin 1 beta	Homo sapiens	37-54
10644962-7	2000	In contrast, cells propagated on SRBSN surfaces expressed the same level of IL-1beta and TNF-alpha as that of control cells.	srbsn	33-38	interleukin 1 beta	Homo sapiens	76-84
10699967-1	2000	We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A.	2-(methylamino)isobutyric acid	116-121	interleukin 1 beta	Homo sapiens	56-64
10699967-2	2000	We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant increase in prostaglandin E(2) (PGE(2)) synthesis.	2-(methylamino)isobutyric acid	51-56	interleukin 1 beta	Homo sapiens	14-22
10699967-2	2000	We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant increase in prostaglandin E(2) (PGE(2)) synthesis.	Dinoprostone	133-151	interleukin 1 beta	Homo sapiens	14-22
10699967-2	2000	We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant increase in prostaglandin E(2) (PGE(2)) synthesis.	Prostaglandins E	153-156	interleukin 1 beta	Homo sapiens	14-22
10699967-4	2000	We found that exogenous PGE(2) inhibited MeAIB uptake, and that AH6809, a PGE(2) receptor antagonist, inhibited IL-1beta-mediated MeAIB uptake.	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	64-70	interleukin 1 beta	Homo sapiens	112-120
10699967-4	2000	We found that exogenous PGE(2) inhibited MeAIB uptake, and that AH6809, a PGE(2) receptor antagonist, inhibited IL-1beta-mediated MeAIB uptake.	2-(methylamino)isobutyric acid	130-135	interleukin 1 beta	Homo sapiens	112-120
10699967-5	2000	To identify the enzymes involved in the IL-1beta-mediated synthesis of PGE(2) that inhibits MeAIB uptake, we studied the expression of secreted (s) and cytosolic (c) phospholipase A(2) (PLA(2)).	Prostaglandins E	71-74	interleukin 1 beta	Homo sapiens	40-48
10699967-5	2000	To identify the enzymes involved in the IL-1beta-mediated synthesis of PGE(2) that inhibits MeAIB uptake, we studied the expression of secreted (s) and cytosolic (c) phospholipase A(2) (PLA(2)).	2-(methylamino)isobutyric acid	92-97	interleukin 1 beta	Homo sapiens	40-48
10699967-8	2000	Our results suggest that the PLA(2) involved in the IL-1beta-mediated synthesis of PGE(2) was sPLA(2).	Prostaglandins E	83-86	interleukin 1 beta	Homo sapiens	52-60
10699967-11	2000	The Il-1beta-induced inhibition of MeAIB uptake in human osteoarthritic synovial cells thus seems to be essentially mediated by PGE(2) production via the activation of sPLA(2) and the partial activation of COX-2.	2-(methylamino)isobutyric acid	35-40	interleukin 1 beta	Homo sapiens	4-12
10699967-11	2000	The Il-1beta-induced inhibition of MeAIB uptake in human osteoarthritic synovial cells thus seems to be essentially mediated by PGE(2) production via the activation of sPLA(2) and the partial activation of COX-2.	Prostaglandins E	128-131	interleukin 1 beta	Homo sapiens	4-12
10779013-3	2000	The NOS-2 activity, assessed by nitrite accumulation, was absent from untreated cultures but was induced by interleukin-1beta and interferon-gamma acting synergistically.	Nitrites	32-39	interleukin 1 beta	Homo sapiens	108-125
11193500-6	2000	COX-2 has been focused as a key enzyme to regulate PGE2 synthesis and plays an important role in inflammation, because COX-2 was induced in many types of cells by the stimulation of inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha).	Dinoprostone	51-55	interleukin 1 beta	Homo sapiens	213-231
10863961-5	2000	In contrast, 45Ca release induced by IL-1 alpha, IL-1 beta, thrombin and bradykinin was significantly reduced by indomethacin, whereas the effects of PTH and PTHrP were unaffected by indomethacin.	Indomethacin	113-125	interleukin 1 beta	Homo sapiens	49-58
10734024-9	2000	Butyrate did, however, enhance formation of the stronger p65-p50 transcriptional activator in IL-1beta-stimulated cells.	Butyrates	0-8	interleukin 1 beta	Homo sapiens	94-102
11193500-6	2000	COX-2 has been focused as a key enzyme to regulate PGE2 synthesis and plays an important role in inflammation, because COX-2 was induced in many types of cells by the stimulation of inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha).	Dinoprostone	51-55	interleukin 1 beta	Homo sapiens	233-242
10742149-4	2000	Both in vivo and in vitro, carbon monoxide at low concentrations differentially and selectively inhibited the expression of lipopolysaccharide-induced pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and macrophage inflammatory protein-1beta and increased the lipopolysaccharide-induced expression of the anti-inflammatory cytokine interleukin-10.	Carbon Monoxide	27-42	interleukin 1 beta	Homo sapiens	207-224
10733012-9	2000	Staurosporine inhibited IL-1beta-induced TF activity in the primary astrocytes but did not effect IL-1beta- or TNFalpha-induced TF activity in the astrocytoma cells.	Staurosporine	0-13	interleukin 1 beta	Homo sapiens	24-32
10742151-3	2000	Furthermore, two different signal transduction pathways were activated by exogenous HSP70: one dependent on CD14 and intracellular calcium, which resulted in increased IL-1beta, IL-6 and TNF-alpha; and the other independent of CD14 but dependent on intracellular calcium, which resulted in an increase in TNF-alpha but not IL-1beta or IL-6.	Calcium	131-138	interleukin 1 beta	Homo sapiens	168-176
10734059-3	2000	In the present study, the role of the EGF receptor signaling pathway and the effects of the cytokines tumor necrosis factor-alpha (TNF-alpha) and and interleukin 1beta (IL-1beta) on triacylglycerol-rich lipoprotein secretion were investigated.	Triglycerides	182-197	interleukin 1 beta	Homo sapiens	150-167
10734059-8	2000	Moreover, phosphotyrosine immunoblots of the EGF receptor demonstrated an increase in tyrosine residues phosphorylated by 0.5 and 6.5 h. At both these time points, TNF-alpha and IL-1beta also decreased the binding of EGF to its cell surface receptor.	Phosphotyrosine	10-25	interleukin 1 beta	Homo sapiens	178-186
10734059-3	2000	In the present study, the role of the EGF receptor signaling pathway and the effects of the cytokines tumor necrosis factor-alpha (TNF-alpha) and and interleukin 1beta (IL-1beta) on triacylglycerol-rich lipoprotein secretion were investigated.	Triglycerides	182-197	interleukin 1 beta	Homo sapiens	169-177
10734059-6	2000	Tyrphostin, an inhibitor of the EGF receptor intrinsic tryosine kinase, prevented or markedly attenuated the decrease in apoB secretion by TNF-alpha or IL-1beta.	Tyrphostins	0-10	interleukin 1 beta	Homo sapiens	152-160
10677576-6	2000	We then investigated the effects of transfection of monocytes with these oligonucleotides on interleukin-1beta (IL-1beta)-stimulated IL-8 production, IL-8 mRNA expression, and NF-kappaB binding activity.	Oligonucleotides	73-89	interleukin 1 beta	Homo sapiens	93-110
10722729-0	2000	Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation.	Retinoids	29-37	interleukin 1 beta	Homo sapiens	0-17
10725293-4	2000	Two weeks after the operation, as reported previously, intracoronary serotonin repeatedly induced coronary hypercontractions at the IL-1beta-treated site both in vivo and in vitro, which were markedly inhibited by Y-27632, one of the specific inhibitors of Rho-kinase.	Serotonin	69-78	interleukin 1 beta	Homo sapiens	132-140
10725293-4	2000	Two weeks after the operation, as reported previously, intracoronary serotonin repeatedly induced coronary hypercontractions at the IL-1beta-treated site both in vivo and in vitro, which were markedly inhibited by Y-27632, one of the specific inhibitors of Rho-kinase.	Y 27632	214-221	interleukin 1 beta	Homo sapiens	132-140
10719064-0	2000	Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress.	Corticosterone	15-29	interleukin 1 beta	Homo sapiens	77-94
10719064-4	2000	A prior report indicated that exposure to inescapable tailshocks (IS) raised levels of brain IL-1beta protein 2 h after IS, but only in adrenalectomized (and basal corticosterone replaced) subjects.	Corticosterone	164-178	interleukin 1 beta	Homo sapiens	93-101
10719064-10	2000	Finally, the administration of corticosterone in an amount that led to blood levels in adrenalectomized subjects that match those produced by IS, inhibited the IS-induced rise in IL-1beta in hypothalamus and pituitary, but not in other brain regions or blood.	Corticosterone	31-45	interleukin 1 beta	Homo sapiens	179-187
10677576-6	2000	We then investigated the effects of transfection of monocytes with these oligonucleotides on interleukin-1beta (IL-1beta)-stimulated IL-8 production, IL-8 mRNA expression, and NF-kappaB binding activity.	Oligonucleotides	73-89	interleukin 1 beta	Homo sapiens	112-120
10677576-9	2000	This single-stranded oligonucleotide also inhibited IL-1beta-induced translocation of NF-kappaB to the nucleus and reduced IL-8 mRNA expression.	Oligonucleotides	21-36	interleukin 1 beta	Homo sapiens	52-60
10704748-1	2000	The effects of the pro-inflammatory cytokine interleukin-1-beta (IL-1beta) on levels of intracellular calcium [Ca(2+)](i) in cultured human microglia have been studied using the fluorescent Ca(2+) indicator fura-2.	Calcium	102-109	interleukin 1 beta	Homo sapiens	45-63
10706690-3	2000	The LPS-stimulated activation of CREB and ATF1, the transcription of the cyclooxygenase-2 (COX-2) and IL-1 beta genes (the promoters of which contain a cyclic AMP response element), and the induction of the COX-2 protein were prevented by the same drug combination, as well as by Ro 318220 or H89, potent inhibitors of MSK1/MSK2.	Cyclic AMP	152-162	interleukin 1 beta	Homo sapiens	102-111
10802230-1	2000	The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation.	Superoxides	15-25	interleukin 1 beta	Homo sapiens	125-142
10802230-1	2000	The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation.	Superoxides	15-25	interleukin 1 beta	Homo sapiens	144-152
10802230-1	2000	The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation.	Superoxides	27-31	interleukin 1 beta	Homo sapiens	125-142
10802230-1	2000	The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation.	Superoxides	27-31	interleukin 1 beta	Homo sapiens	144-152
10802230-1	2000	The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation.	Hydrogen Peroxide	41-58	interleukin 1 beta	Homo sapiens	125-142
10802230-1	2000	The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation.	h(2)	60-64	interleukin 1 beta	Homo sapiens	125-142
10802230-1	2000	The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation.	h(2)	60-64	interleukin 1 beta	Homo sapiens	144-152
10802230-1	2000	The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation.	Selenium	240-248	interleukin 1 beta	Homo sapiens	125-142
10802230-1	2000	The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation.	Selenium	240-248	interleukin 1 beta	Homo sapiens	144-152
10704748-1	2000	The effects of the pro-inflammatory cytokine interleukin-1-beta (IL-1beta) on levels of intracellular calcium [Ca(2+)](i) in cultured human microglia have been studied using the fluorescent Ca(2+) indicator fura-2.	Calcium	102-109	interleukin 1 beta	Homo sapiens	65-73
10704748-1	2000	The effects of the pro-inflammatory cytokine interleukin-1-beta (IL-1beta) on levels of intracellular calcium [Ca(2+)](i) in cultured human microglia have been studied using the fluorescent Ca(2+) indicator fura-2.	Fura-2	207-213	interleukin 1 beta	Homo sapiens	65-73
10704748-2	2000	IL-1beta (2 ng/ml) caused a slow, progressive increase in [Ca(2+)](i) in standard Ca(2+)-containing physiological solution (PSS).	pss	124-127	interleukin 1 beta	Homo sapiens	0-8
10704748-4	2000	Similar results were obtained in a separate protocol, where cells were exposed to both IL-1beta in Ca(2+)-free PSS and PSS.	pss	111-114	interleukin 1 beta	Homo sapiens	87-95
10704748-5	2000	The slope of the IL-1beta induced increase of [Ca(2+)](i) in Ca(2+)-free PSS was not altered when adenosine triphosphate was added prior to application of the cytokine.	pss	73-76	interleukin 1 beta	Homo sapiens	17-25
10704748-5	2000	The slope of the IL-1beta induced increase of [Ca(2+)](i) in Ca(2+)-free PSS was not altered when adenosine triphosphate was added prior to application of the cytokine.	Adenosine Triphosphate	98-120	interleukin 1 beta	Homo sapiens	17-25
10704748-6	2000	These results suggest that IL-1beta-induced responses in human microglia involve both a Ca(2+) entry pathway and a mechanism of intracellular increase other than from IP(3)-sensitive stores.	ip	167-169	interleukin 1 beta	Homo sapiens	27-35
10704772-0	2000	CPI-1189 inhibits interleukin 1beta-induced p38-mitogen-activated protein kinase phosphorylation: an explanation for its neuroprotective properties?	CPI 1189	0-8	interleukin 1 beta	Homo sapiens	18-35
10704772-8	2000	In primary astrocytes treated with interleukin 1beta (IL1beta), CPI-1189 inhibits p38-MAPK phosphorylation at concentrations of 10 nM or less.	CPI 1189	64-72	interleukin 1 beta	Homo sapiens	35-52
10704772-8	2000	In primary astrocytes treated with interleukin 1beta (IL1beta), CPI-1189 inhibits p38-MAPK phosphorylation at concentrations of 10 nM or less.	CPI 1189	64-72	interleukin 1 beta	Homo sapiens	54-61
10652212-15	2000	Cell proliferation stimulated by IL-1beta was reduced by the addition of the Arom inhibitor fadrozole-HCL (CGS-16949A).	Fadrozole	92-105	interleukin 1 beta	Homo sapiens	33-41
10712238-1	2000	Treatment of human leukemia THP-1 cells with bufalin, a specific inhibitor of Na(+)-K(+)-ATPase, sequentially induces c-fos and inflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) gene expressions before the appearance of mature phenotypes of monocytic cells.	bufalin	45-52	interleukin 1 beta	Homo sapiens	151-169
10712238-1	2000	Treatment of human leukemia THP-1 cells with bufalin, a specific inhibitor of Na(+)-K(+)-ATPase, sequentially induces c-fos and inflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) gene expressions before the appearance of mature phenotypes of monocytic cells.	bufalin	45-52	interleukin 1 beta	Homo sapiens	171-180
10712238-4	2000	Pretreatment of THP-1 cells with PD-98059, an inhibitor of the ERK-kinase cascade, abolished bufalin-induced c-fos and IL-1 beta gene expressions, indicating that the ERK-kinase cascade mediates the induction of inflammatory cytokines by bufalin.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	33-41	interleukin 1 beta	Homo sapiens	119-128
10712238-4	2000	Pretreatment of THP-1 cells with PD-98059, an inhibitor of the ERK-kinase cascade, abolished bufalin-induced c-fos and IL-1 beta gene expressions, indicating that the ERK-kinase cascade mediates the induction of inflammatory cytokines by bufalin.	bufalin	93-100	interleukin 1 beta	Homo sapiens	119-128
10712238-7	2000	In cells treated with an inhibitor of p38 MAP kinases, SB-203580, bufalin-mediated ERK activation became persistent and the induction of IL-1 beta and TNF-alpha expressions was significantly augmented.	SB 203580	55-64	interleukin 1 beta	Homo sapiens	137-146
10704258-7	2000	Ouabain induced the production of IL-1alpha, IL-1beta and IL-6, but not of TNF-alpha.	Ouabain	0-7	interleukin 1 beta	Homo sapiens	45-53
10704258-10	2000	IL-1beta production was also inhibited by 30 micromol/l amlodipine.	Amlodipine	56-66	interleukin 1 beta	Homo sapiens	0-8
10704258-12	2000	The unique property of amlodipine to inhibit the production of IL-1alpha, IL-1beta and IL-6 may contribute to its beneficial effects in heart failure patients.	Amlodipine	23-33	interleukin 1 beta	Homo sapiens	74-82
10723095-6	2000	Hyaluronan production was increased by all treatments: 1.7-fold by IL-1beta and 1.5-fold by TNF-alpha.	Hyaluronic Acid	0-10	interleukin 1 beta	Homo sapiens	67-75
10675243-9	2000	Both the secretory phospholipase A2 inhibitor p-bromophenylacyl bromide and the cytosolic phospholipase A2 inhibitor arachidonyl trifluoromethyl ketone decreased basal and interleukin-1beta-stimulated arachidonic acid release.	p-bromophenylacyl bromide	46-71	interleukin 1 beta	Homo sapiens	172-189
10675243-9	2000	Both the secretory phospholipase A2 inhibitor p-bromophenylacyl bromide and the cytosolic phospholipase A2 inhibitor arachidonyl trifluoromethyl ketone decreased basal and interleukin-1beta-stimulated arachidonic acid release.	arachidonyltrifluoromethane	117-151	interleukin 1 beta	Homo sapiens	172-189
10675243-10	2000	In contrast, only inhibition of cytosolic phospholipase A2 led to a decrease in interleukin-1beta-stimulated prostaglandin E2 release.	Dinoprostone	109-125	interleukin 1 beta	Homo sapiens	80-97
10675243-11	2000	Basal and interleukin-1beta-stimulated arachidonic acid release appears to be the result of the activity of both cytosolic and secretory phospholipase A2.	Arachidonic Acid	39-55	interleukin 1 beta	Homo sapiens	10-27
10675243-12	2000	Interleukin-1beta-stimulated prostaglandin E2 release appears to be dependent on the activity of cytosolic phospholipase A2.	Dinoprostone	29-45	interleukin 1 beta	Homo sapiens	0-17
10736970-16	2000	Both PGE2 and DBcAMP also attenuated the IL-1 beta-stimulated migration of monocytes.	Dinoprostone	5-9	interleukin 1 beta	Homo sapiens	41-50
10736970-16	2000	Both PGE2 and DBcAMP also attenuated the IL-1 beta-stimulated migration of monocytes.	Bucladesine	14-20	interleukin 1 beta	Homo sapiens	41-50
10718382-6	2000	Tolerance is specific for endotoxin, because phorbol ester is still able to activate transcription of the endogenous interleukin 1beta gene and transfected reporter genes.	Phorbol Esters	45-58	interleukin 1 beta	Homo sapiens	117-134
10657679-6	2000	The protein tyrosine kinase inhibitor herbimycin A completely eliminated the protective effect of IL-1 beta on CD95-induced apoptosis.	herbimycin	38-50	interleukin 1 beta	Homo sapiens	98-107
10657679-7	2000	These findings suggest that IL-1 beta modulates the CD95 death cascade in chondrocytes by mechanisms that involve tyrosine phosphorylation events and NF-kappa B-dependent gene activation.	Tyrosine	114-122	interleukin 1 beta	Homo sapiens	28-37
10772282-1	2000	The in vitro effect of indomethacin (IM) on the production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)alpha by cord blood mononuclear cells (CBMC) from preterm newborns was compared to that of peripheral blood MC of adults (PBMC).	Indomethacin	23-35	interleukin 1 beta	Homo sapiens	62-84
10772282-1	2000	The in vitro effect of indomethacin (IM) on the production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)alpha by cord blood mononuclear cells (CBMC) from preterm newborns was compared to that of peripheral blood MC of adults (PBMC).	Indomethacin	37-39	interleukin 1 beta	Homo sapiens	62-84
10772282-4	2000	MC isolated from preterm newborns were less sensitive to the in vitro effect of IM on IL-1beta and TNFalpha secretion than adult cells.	Methylcholanthrene	0-2	interleukin 1 beta	Homo sapiens	86-94
10735588-8	2000	IL-1 beta (5-50 ng/mL) increased the basal, but not LH-dependent, progesterone production from these cells in a dose-dependent manner after 96 and 144 hr of culture (P&lt;0.05).	Progesterone	66-78	interleukin 1 beta	Homo sapiens	0-9
10735588-9	2000	However, an inhibitory effect of IL-1 beta on LH-dependent estradiol production was observed (up to 20% decrease, P&lt;0.05).	Luteinizing Hormone	46-48	interleukin 1 beta	Homo sapiens	33-42
10735588-9	2000	However, an inhibitory effect of IL-1 beta on LH-dependent estradiol production was observed (up to 20% decrease, P&lt;0.05).	Estradiol	59-68	interleukin 1 beta	Homo sapiens	33-42
10807502-5	2000	RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.	4'-hydroxyaceclofenac	9-31	interleukin 1 beta	Homo sapiens	98-106
10807502-5	2000	RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.	aceclofenac	20-31	interleukin 1 beta	Homo sapiens	98-106
10807502-5	2000	RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.	prommp-1	129-137	interleukin 1 beta	Homo sapiens	98-106
10807502-5	2000	RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.	Dinoprostone	193-197	interleukin 1 beta	Homo sapiens	98-106
10807502-5	2000	RESULTS: 4"-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1beta-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.	aceclofenac	55-66	interleukin 1 beta	Homo sapiens	98-106
10750554-7	2000	Two normal women were heterozygous for a shift from cytosine to thymine (C3263-T) in exon 4 of the IL-1beta gene.	Cytosine	52-60	interleukin 1 beta	Homo sapiens	99-107
10750554-7	2000	Two normal women were heterozygous for a shift from cytosine to thymine (C3263-T) in exon 4 of the IL-1beta gene.	Thymine	64-71	interleukin 1 beta	Homo sapiens	99-107
10679106-0	2000	Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases.	lipoxin A4	0-10	interleukin 1 beta	Homo sapiens	20-29
10679106-6	2000	At nanomolar concentrations, LXA4 inhibited these IL-1 beta responses with reduction of IL-6 and IL-8 synthesis, by 45 +/- 7% and 75 +/- 11%, respectively, and prevented IL-1 beta-induced MMP-3 synthesis without significantly affecting MMP-1 levels.	lipoxin A4	29-33	interleukin 1 beta	Homo sapiens	50-59
10679106-6	2000	At nanomolar concentrations, LXA4 inhibited these IL-1 beta responses with reduction of IL-6 and IL-8 synthesis, by 45 +/- 7% and 75 +/- 11%, respectively, and prevented IL-1 beta-induced MMP-3 synthesis without significantly affecting MMP-1 levels.	lipoxin A4	29-33	interleukin 1 beta	Homo sapiens	170-179
10688620-2	2000	IL-1beta is an activator of the serotonin transporter gene expression in JAR human placental choriocarcinoma cells as demonstrated by an increase in the steady-state levels of the transporter mRNA and in serotonin transport activity.	Serotonin	32-41	interleukin 1 beta	Homo sapiens	0-8
10688620-4	2000	Genistein also blocks the effect of IL-1beta, indicating involvement of tyrosine phosphorylation in the process.	Genistein	0-9	interleukin 1 beta	Homo sapiens	36-44
10688620-4	2000	Genistein also blocks the effect of IL-1beta, indicating involvement of tyrosine phosphorylation in the process.	Tyrosine	72-80	interleukin 1 beta	Homo sapiens	36-44
24383530-10	2000	The addition of latex and polyethylene particles to human M/M resulted in a dose-dependent increase in IL-1beta, IL-6, and TNF-alpha release.	Latex	16-21	interleukin 1 beta	Homo sapiens	103-111
24383530-10	2000	The addition of latex and polyethylene particles to human M/M resulted in a dose-dependent increase in IL-1beta, IL-6, and TNF-alpha release.	Polyethylene	26-38	interleukin 1 beta	Homo sapiens	103-111
10731036-2	2000	We reported previously that IL-1beta induced a prostanoid-dependent increase in the density of bradykinin B2 receptors in cultured human bronchial smooth muscle cells.	Prostaglandins	47-57	interleukin 1 beta	Homo sapiens	28-36
10731036-3	2000	Our experiments demonstrate that the rapid prostaglandin E2 (PGE2) synthesis induced by IL-1beta is abolished by cycloheximide, suggesting the involvement of protein synthesis.	Dinoprostone	43-59	interleukin 1 beta	Homo sapiens	88-96
10731036-3	2000	Our experiments demonstrate that the rapid prostaglandin E2 (PGE2) synthesis induced by IL-1beta is abolished by cycloheximide, suggesting the involvement of protein synthesis.	Dinoprostone	61-65	interleukin 1 beta	Homo sapiens	88-96
10731036-3	2000	Our experiments demonstrate that the rapid prostaglandin E2 (PGE2) synthesis induced by IL-1beta is abolished by cycloheximide, suggesting the involvement of protein synthesis.	Cycloheximide	113-126	interleukin 1 beta	Homo sapiens	88-96
10731036-7	2000	These data demonstrate that the activation of p38 MAP kinase elicited by IL-1beta leads to the phosphorylation of cPLA2 and Cox-2 overexpression, allowing rapid synthesis of PGE2 as a prerequisite for bradykinin B2 gene expression in human bronchial smooth muscle cells which could explain the hyperresponsiveness of asthmatic patients to bradykinin.	Dinoprostone	174-178	interleukin 1 beta	Homo sapiens	73-81
10681439-0	2000	IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma.	Prostaglandins	61-74	interleukin 1 beta	Homo sapiens	0-4
10681439-2	2000	Because of these similarities, IL-18 was investigated for its ability to induce prostaglandin E(2) (PGE(2)) synthesis in human peripheral blood mononuclear cells (PBMC), a prominent, proinflammatory property of IL-1.	Dinoprostone	80-98	interleukin 1 beta	Homo sapiens	31-35
10681439-2	2000	Because of these similarities, IL-18 was investigated for its ability to induce prostaglandin E(2) (PGE(2)) synthesis in human peripheral blood mononuclear cells (PBMC), a prominent, proinflammatory property of IL-1.	Dinoprostone	100-106	interleukin 1 beta	Homo sapiens	31-35
10681439-4	2000	In the same cultures, IL-1beta induced a 12-fold increase in PGE(2).	Prostaglandins E	61-64	interleukin 1 beta	Homo sapiens	22-30
10681439-5	2000	Although IL-1beta-induced IL-8 synthesis was augmented 3-fold by IL-18, IL-18 suppressed IL-1beta-induced PGE(2) production by 40%.	Prostaglandins E	106-109	interleukin 1 beta	Homo sapiens	89-97
10681439-7	2000	Consistent with these observations, IL-12, a known inducer of IFN-gamma, augmented IL-1beta-induced IFN-gamma but suppressed IL-1beta-induced PGE(2) by 75%.	Prostaglandins E	142-145	interleukin 1 beta	Homo sapiens	125-133
10681439-10	2000	PGE(2) production was also increased by the addition of IL-18BP to PBMC stimulated with either IL-1beta or IL-12 and also in whole blood cultures stimulated with Staphylococcus epidermidis.	Dinoprostone	0-6	interleukin 1 beta	Homo sapiens	95-103
10657593-5	2000	The protein kinase C (PKC) inhibitors H7 (50 microM) and GF109203X (1 microM) inhibited the stimulatory effect of IL-1beta.	bisindolylmaleimide I	57-66	interleukin 1 beta	Homo sapiens	114-122
10675727-2	2000	Here, we show that selective inhibitors and antisense oligonucleotides against this enzyme suppressed expression of the interleukin-1beta gene at the level of transcription and promoter activation in human monocytic cell lines.	Oligonucleotides	54-70	interleukin 1 beta	Homo sapiens	120-137
10652212-15	2000	Cell proliferation stimulated by IL-1beta was reduced by the addition of the Arom inhibitor fadrozole-HCL (CGS-16949A).	cysteinylglycine	107-110	interleukin 1 beta	Homo sapiens	33-41
10690908-4	2000	In the present study we report that estradiol (E2) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1-induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid (mRNA) synthesis, whereas progesterone had no significant effects.	Estradiol	36-45	interleukin 1 beta	Homo sapiens	126-143
10666117-4	2000	Furthermore, superoxide production by IL-1beta, PDGF factor, and constitutively activated Ras is blocked by diphenyleneiodonium, implicating NAD(P)H oxidase as the generating enzyme.	Superoxides	13-23	interleukin 1 beta	Homo sapiens	38-46
10666117-4	2000	Furthermore, superoxide production by IL-1beta, PDGF factor, and constitutively activated Ras is blocked by diphenyleneiodonium, implicating NAD(P)H oxidase as the generating enzyme.	diphenyleneiodonium	108-127	interleukin 1 beta	Homo sapiens	38-46
10657942-5	2000	In contrast, the addition of DEX relieved the IL-1beta-mediated inhibition of FBG expression in lung epithelial cells only; this response is termed "DEX rescue."	Dexamethasone	29-32	interleukin 1 beta	Homo sapiens	46-54
10657942-5	2000	In contrast, the addition of DEX relieved the IL-1beta-mediated inhibition of FBG expression in lung epithelial cells only; this response is termed "DEX rescue."	Dexamethasone	149-152	interleukin 1 beta	Homo sapiens	46-54
10657942-10	2000	Also, the data suggest that DEX induces new protein synthesis of an inhibitor of IL-1beta signal transduction to effectively "rescue" FBG production in lung but not liver epithelial cells.	Dexamethasone	28-31	interleukin 1 beta	Homo sapiens	81-89
10708165-10	2000	The peak concentration of IL-1beta was significantly correlated with the level of bilirubin at admission and the intraoperative blood product requirement.	Bilirubin	82-91	interleukin 1 beta	Homo sapiens	26-34
10708165-12	2000	A multivariate regression model revealed that the serum bilirubin and the intraoperative blood product requirement were the independent factors that influenced the peak concentration of IL-1beta or IL-6.	Bilirubin	56-65	interleukin 1 beta	Homo sapiens	186-194
10900556-11	2000	Stress by addition of interleukin-1 beta resulted in the maintenance or the increase in de novo synthesised RNA-purine nucleotides, even in the presence of exogenous nucleotides.	purine	112-118	interleukin 1 beta	Homo sapiens	22-40
10900556-12	2000	However, the addition of interleukin-1 beta to the culture medium led to an enhanced salvage of preformed pyrimidine nucleotides for nucleic acid synthesis when glutamine was present in the medium at a concentration of 0.5 mmol/L.	Pyrimidine Nucleotides	106-128	interleukin 1 beta	Homo sapiens	25-43
10900556-12	2000	However, the addition of interleukin-1 beta to the culture medium led to an enhanced salvage of preformed pyrimidine nucleotides for nucleic acid synthesis when glutamine was present in the medium at a concentration of 0.5 mmol/L.	Glutamine	161-170	interleukin 1 beta	Homo sapiens	25-43
10666117-1	2000	We recently showed that the farnesyltransferase inhibitor FTI-277 blocks interleukin 1beta (IL-1beta)-induced nitric oxide production in pulmonary vascular smooth muscle cells (SMC), whereas the geranylgeranyltransferase inhibitor GGTI-298 enhances this effect.	FTI 277	58-65	interleukin 1 beta	Homo sapiens	73-90
10666117-1	2000	We recently showed that the farnesyltransferase inhibitor FTI-277 blocks interleukin 1beta (IL-1beta)-induced nitric oxide production in pulmonary vascular smooth muscle cells (SMC), whereas the geranylgeranyltransferase inhibitor GGTI-298 enhances this effect.	FTI 277	58-65	interleukin 1 beta	Homo sapiens	92-100
10666117-1	2000	We recently showed that the farnesyltransferase inhibitor FTI-277 blocks interleukin 1beta (IL-1beta)-induced nitric oxide production in pulmonary vascular smooth muscle cells (SMC), whereas the geranylgeranyltransferase inhibitor GGTI-298 enhances this effect.	Nitric Oxide	110-122	interleukin 1 beta	Homo sapiens	73-90
10666117-1	2000	We recently showed that the farnesyltransferase inhibitor FTI-277 blocks interleukin 1beta (IL-1beta)-induced nitric oxide production in pulmonary vascular smooth muscle cells (SMC), whereas the geranylgeranyltransferase inhibitor GGTI-298 enhances this effect.	Nitric Oxide	110-122	interleukin 1 beta	Homo sapiens	92-100
10666117-2	2000	Here we show that IL-1beta and platelet-derived growth factor (PDGF) stimulate superoxide production by pulmonary vascular SMC and that this effect is blocked by both FTI-277 and GGTI-298, suggesting that farnesylated and geranylgeranylated proteins are required for superoxide production.	Superoxides	79-89	interleukin 1 beta	Homo sapiens	18-26
10666117-2	2000	Here we show that IL-1beta and platelet-derived growth factor (PDGF) stimulate superoxide production by pulmonary vascular SMC and that this effect is blocked by both FTI-277 and GGTI-298, suggesting that farnesylated and geranylgeranylated proteins are required for superoxide production.	Superoxides	267-277	interleukin 1 beta	Homo sapiens	18-26
10617906-6	2000	RESULTS: The concentration of HA in conditioned medium of HTF was significantly increased only after stimulation with PDGF-AA [10 and 100ng/ml], IL-1beta [1 and 10ng/ml] and TGF-beta1 [5ng/ml].	ha	30-32	interleukin 1 beta	Homo sapiens	145-153
10690908-4	2000	In the present study we report that estradiol (E2) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1-induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid (mRNA) synthesis, whereas progesterone had no significant effects.	Progesterone	329-341	interleukin 1 beta	Homo sapiens	126-143
10640285-2	2000	IL-1beta action on the gamma-aminobutyric acid type A (GABA(A)) inhibitory neurotransmitter receptor was investigated in whole cell patch-clamped cultured hippocampal neurons.	gamma-Aminobutyric Acid	23-46	interleukin 1 beta	Homo sapiens	0-8
10640285-2	2000	IL-1beta action on the gamma-aminobutyric acid type A (GABA(A)) inhibitory neurotransmitter receptor was investigated in whole cell patch-clamped cultured hippocampal neurons.	gamma-Aminobutyric Acid	55-59	interleukin 1 beta	Homo sapiens	0-8
10640285-3	2000	Application of IL-1beta at concentrations encountered in pathophysiological conditions (1-10 ng/ml; 59-590 pM) irreversibly decreased the peak magnitude of current elicited by 30 microM GABA.	gamma-Aminobutyric Acid	186-190	interleukin 1 beta	Homo sapiens	15-23
10619820-0	2000	Nitric oxide modulates interleukin-1beta and tumor necrosis factor-alpha synthesis by alveolar macrophages in pulmonary tuberculosis.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	23-72
10675272-5	2000	In addition to TNF, melanin inhibited production of interleukin (IL)-1beta, IL-6, and IL-10 but not granulocyte-macrophage colony-stimulating factor by the LPS-stimulated monocytes.	Melanins	20-27	interleukin 1 beta	Homo sapiens	52-74
10701683-9	2000	Electrophoretic mobility shift assay demonstrated that DNA-binding activity of NF-KB was suppressed more profoundly by FK506 plus DEX (10(-9) M) treatment with those of DEX (10(-9)M) alone in IL-1beta-stimulated synovial cells.	Tacrolimus	119-124	interleukin 1 beta	Homo sapiens	192-200
10701683-9	2000	Electrophoretic mobility shift assay demonstrated that DNA-binding activity of NF-KB was suppressed more profoundly by FK506 plus DEX (10(-9) M) treatment with those of DEX (10(-9)M) alone in IL-1beta-stimulated synovial cells.	Dexamethasone	130-133	interleukin 1 beta	Homo sapiens	192-200
10701683-9	2000	Electrophoretic mobility shift assay demonstrated that DNA-binding activity of NF-KB was suppressed more profoundly by FK506 plus DEX (10(-9) M) treatment with those of DEX (10(-9)M) alone in IL-1beta-stimulated synovial cells.	Dexamethasone	169-172	interleukin 1 beta	Homo sapiens	192-200
10619820-7	2000	L-NMMA inhibited nitrite, IL-1beta, and TNF-alpha production in TB patients.	omega-N-Methylarginine	0-6	interleukin 1 beta	Homo sapiens	26-34
10619820-8	2000	The mRNA expression for IL-1beta and TNF-alpha was upregulated in TB patients and was depressed by L-NMMA.	omega-N-Methylarginine	99-105	interleukin 1 beta	Homo sapiens	24-32
10619820-10	2000	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis.	pyrrolidine dithiocarbamic acid	27-54	interleukin 1 beta	Homo sapiens	66-74
10619824-8	2000	In vitro studies of A549 epithelial cells stimulated by interleukin-1beta (IL-1beta) showed that dexamethasone increased p65 protein expression analyzed by Western blot.	Dexamethasone	97-110	interleukin 1 beta	Homo sapiens	56-73
10619824-8	2000	In vitro studies of A549 epithelial cells stimulated by interleukin-1beta (IL-1beta) showed that dexamethasone increased p65 protein expression analyzed by Western blot.	Dexamethasone	97-110	interleukin 1 beta	Homo sapiens	75-83
11128552-6	2000	Our data indicate that induction of NO biosynthesis by IL-1beta depends on external arginine when cells are arginine-depleted for 24 hours.	Arginine	84-92	interleukin 1 beta	Homo sapiens	55-63
11128552-6	2000	Our data indicate that induction of NO biosynthesis by IL-1beta depends on external arginine when cells are arginine-depleted for 24 hours.	Arginine	108-116	interleukin 1 beta	Homo sapiens	55-63
10912627-0	2000	Interleukin 1beta decreases the GSH content and catalase activity in the human peritoneal mesothelial cells in vitro.	Glutathione	32-35	interleukin 1 beta	Homo sapiens	0-17
11268388-3	2000	Interleukin-1 beta (IL-1 beta) stimulates IL-6 release from anterior pituitary cells through a mechanism that involves lysophosphatidylcholine (LPC 18:0) generation and protein kinase C activation.	Lysophosphatidylcholines	119-142	interleukin 1 beta	Homo sapiens	0-18
11268388-3	2000	Interleukin-1 beta (IL-1 beta) stimulates IL-6 release from anterior pituitary cells through a mechanism that involves lysophosphatidylcholine (LPC 18:0) generation and protein kinase C activation.	Lysophosphatidylcholines	119-142	interleukin 1 beta	Homo sapiens	20-29
11268388-5	2000	The catecholamines and serotonin also synergistically stimulate IL-6 release in the presence of IL-1 beta.	Catecholamines	4-18	interleukin 1 beta	Homo sapiens	96-105
11268388-5	2000	The catecholamines and serotonin also synergistically stimulate IL-6 release in the presence of IL-1 beta.	Serotonin	23-32	interleukin 1 beta	Homo sapiens	96-105
11268335-4	2000	Our behavioral and electrophysiological studies have revealed that IL-1 beta in the brain induces hyperalgesia through the actions of prostaglandin E2 (PGE2) on EP3 receptors in the preoptic area and its neighboring basal forebrain, whereas the IL-1 beta-induced analgesia is produced by the actions of PGE2 on EP1 receptors in the ventromedial hypothalamus.	Dinoprostone	134-150	interleukin 1 beta	Homo sapiens	67-76
11268335-4	2000	Our behavioral and electrophysiological studies have revealed that IL-1 beta in the brain induces hyperalgesia through the actions of prostaglandin E2 (PGE2) on EP3 receptors in the preoptic area and its neighboring basal forebrain, whereas the IL-1 beta-induced analgesia is produced by the actions of PGE2 on EP1 receptors in the ventromedial hypothalamus.	Dinoprostone	152-156	interleukin 1 beta	Homo sapiens	67-76
11268335-4	2000	Our behavioral and electrophysiological studies have revealed that IL-1 beta in the brain induces hyperalgesia through the actions of prostaglandin E2 (PGE2) on EP3 receptors in the preoptic area and its neighboring basal forebrain, whereas the IL-1 beta-induced analgesia is produced by the actions of PGE2 on EP1 receptors in the ventromedial hypothalamus.	Dinoprostone	152-156	interleukin 1 beta	Homo sapiens	245-254
11268335-4	2000	Our behavioral and electrophysiological studies have revealed that IL-1 beta in the brain induces hyperalgesia through the actions of prostaglandin E2 (PGE2) on EP3 receptors in the preoptic area and its neighboring basal forebrain, whereas the IL-1 beta-induced analgesia is produced by the actions of PGE2 on EP1 receptors in the ventromedial hypothalamus.	Dinoprostone	303-307	interleukin 1 beta	Homo sapiens	67-76
10912627-1	2000	The object of this study was to assess the effects of the inflammatory cytokine interleukin 1beta (IL-1beta) (0.01-1.0 ng/ml) on the activity of catalase (CAT), superoxide dismutase (SOD) and the level of glutathione (GSH), all being antioxidant mechanisms, in human peritoneal mesothelial cells (HPMC) in in vitro culture.	Glutathione	205-216	interleukin 1 beta	Homo sapiens	80-97
10912627-1	2000	The object of this study was to assess the effects of the inflammatory cytokine interleukin 1beta (IL-1beta) (0.01-1.0 ng/ml) on the activity of catalase (CAT), superoxide dismutase (SOD) and the level of glutathione (GSH), all being antioxidant mechanisms, in human peritoneal mesothelial cells (HPMC) in in vitro culture.	Glutathione	205-216	interleukin 1 beta	Homo sapiens	99-107
10912627-1	2000	The object of this study was to assess the effects of the inflammatory cytokine interleukin 1beta (IL-1beta) (0.01-1.0 ng/ml) on the activity of catalase (CAT), superoxide dismutase (SOD) and the level of glutathione (GSH), all being antioxidant mechanisms, in human peritoneal mesothelial cells (HPMC) in in vitro culture.	Glutathione	218-221	interleukin 1 beta	Homo sapiens	80-97
11219391-5	2000	Tumour necrosis factor (TNF) reportedly plays a pivotal role in the pathogenesis o RA, especially its ability to regulate interleukin (IL)-1beta expression, this being important for the induction of prostanoid and matrix metalloproteinase production by synovial fibroblasts and chondrocytes.	Prostaglandins	199-209	interleukin 1 beta	Homo sapiens	122-144
10912627-1	2000	The object of this study was to assess the effects of the inflammatory cytokine interleukin 1beta (IL-1beta) (0.01-1.0 ng/ml) on the activity of catalase (CAT), superoxide dismutase (SOD) and the level of glutathione (GSH), all being antioxidant mechanisms, in human peritoneal mesothelial cells (HPMC) in in vitro culture.	Glutathione	218-221	interleukin 1 beta	Homo sapiens	99-107
10912627-1	2000	The object of this study was to assess the effects of the inflammatory cytokine interleukin 1beta (IL-1beta) (0.01-1.0 ng/ml) on the activity of catalase (CAT), superoxide dismutase (SOD) and the level of glutathione (GSH), all being antioxidant mechanisms, in human peritoneal mesothelial cells (HPMC) in in vitro culture.	hydroxypropylmethylcellulose-lactose matrix	297-301	interleukin 1 beta	Homo sapiens	80-97
10912627-1	2000	The object of this study was to assess the effects of the inflammatory cytokine interleukin 1beta (IL-1beta) (0.01-1.0 ng/ml) on the activity of catalase (CAT), superoxide dismutase (SOD) and the level of glutathione (GSH), all being antioxidant mechanisms, in human peritoneal mesothelial cells (HPMC) in in vitro culture.	hydroxypropylmethylcellulose-lactose matrix	297-301	interleukin 1 beta	Homo sapiens	99-107
10912627-6	2000	The GSH level was decreased in mesothelial cells (MC) after 24 h of exposition to IL-1.	Glutathione	4-7	interleukin 1 beta	Homo sapiens	82-86
10912627-7	2000	However, after 72 h of incubation with IL-1 the GSH level increased in MC in the presence of 10% FCS, p&lt;0.05.	Glutathione	48-51	interleukin 1 beta	Homo sapiens	39-43
10912627-7	2000	However, after 72 h of incubation with IL-1 the GSH level increased in MC in the presence of 10% FCS, p&lt;0.05.	Methylcholanthrene	71-73	interleukin 1 beta	Homo sapiens	39-43
10912627-11	2000	We conclude that the activity of antioxidant mechanisms in MC is decreased by IL-1beta in ways that might increase their vulnerability to the cytotoxic effect of free radicals.	Methylcholanthrene	59-61	interleukin 1 beta	Homo sapiens	78-86
10912627-11	2000	We conclude that the activity of antioxidant mechanisms in MC is decreased by IL-1beta in ways that might increase their vulnerability to the cytotoxic effect of free radicals.	Free Radicals	162-175	interleukin 1 beta	Homo sapiens	78-86
10623444-5	2000	Release of IL-1beta was comparable between the three groups but only detectable in cultures stimulated with lipopolysaccharide; it decreased in patients treated with prednisolone: 3.8 ng/10(6)monocytes (median) vs 11.7 (P=0.045).	Prednisolone	166-178	interleukin 1 beta	Homo sapiens	11-19
10805962-1	2000	Nitric oxide (NO) is a free radical produced during inflammation following activation of an inducible NO synthase by pro-inflammatory cytokines such as IL-1beta.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	152-160
10912189-4	2000	Furthermore, the production of intracellular IL1-beta by LPS- or rhIL1-beta-stimulated chondrocytes was shown to be partly suppressed by rhein (active metabolite of diacerhein) in all culture systems.	diacerein	165-175	interleukin 1 beta	Homo sapiens	45-53
11032359-3	2000	IL-1beta decreased both GGT activity and intracellular GSH content and increased apoE secretion, initiating astroglial response to injury.	Glutathione	55-58	interleukin 1 beta	Homo sapiens	0-8
11032359-5	2000	Our results allow us to conclude that neurological disorders associated with an IL-1beta-induced oxidative stress could be, at least experimentally, reversible in the presence of one antioxidant, N-acetylcysteine.	Acetylcysteine	196-212	interleukin 1 beta	Homo sapiens	80-88
10671814-3	2000	Under a serum-free culture condition, an increase in PGE(2) production by IL-1alpha and IL-1beta was observed at concentrations of 10 and 100 ng/ml compared to control cultures.	Prostaglandins E	53-56	interleukin 1 beta	Homo sapiens	88-96
10867834-7	2000	When cells were preincubated with 10(-4) M CAM for 7 days, the IL-1 beta-induced secretion of IL-8 decreased significantly.	Clarithromycin	43-46	interleukin 1 beta	Homo sapiens	63-72
10642306-4	2000	We tested whether iPLA(2) metabolites are involved in the regulation by IL-1beta of iNOS with the use of bromoenol lactone (BEL), a specific and irreversible inhibitor of iPLA(2).	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	105-122	interleukin 1 beta	Homo sapiens	72-80
10613737-6	2000	[(3)H]Taurocholate ([(3)H]TC) uptake decreased in WIF-B cells exposed to either TNF-alpha (54% of control), IL-1beta (78%), IL-6 (55%) as single additives, or in triple combination (TCC) (43%).	[(3)h]taurocholate	0-18	interleukin 1 beta	Homo sapiens	108-116
10613737-6	2000	[(3)H]Taurocholate ([(3)H]TC) uptake decreased in WIF-B cells exposed to either TNF-alpha (54% of control), IL-1beta (78%), IL-6 (55%) as single additives, or in triple combination (TCC) (43%).	Tritium	0-6	interleukin 1 beta	Homo sapiens	108-116
10642313-2	2000	Others have reported that changes in intracellular calcium (Ca(2+)) mediate the action of IL-1beta.	Calcium	51-58	interleukin 1 beta	Homo sapiens	90-98
10613737-6	2000	[(3)H]Taurocholate ([(3)H]TC) uptake decreased in WIF-B cells exposed to either TNF-alpha (54% of control), IL-1beta (78%), IL-6 (55%) as single additives, or in triple combination (TCC) (43%).	Technetium	26-28	interleukin 1 beta	Homo sapiens	108-116
10613737-10	2000	Blocking antibodies against TNF-alpha, IL-1beta, and IL-6 restored the diminished [(3)H]TC uptake in cells exposed to TCC and CM to 87% and 107% of controls, respectively.	Technetium	88-90	interleukin 1 beta	Homo sapiens	39-47
10613737-10	2000	Blocking antibodies against TNF-alpha, IL-1beta, and IL-6 restored the diminished [(3)H]TC uptake in cells exposed to TCC and CM to 87% and 107% of controls, respectively.	Triclocarban	118-121	interleukin 1 beta	Homo sapiens	39-47
10613737-12	2000	We conclude that macrophages and their ability to secrete the cytokines TNF-alpha, IL-1beta, and IL-6 may be essential in mediating the endotoxin-induced cholestatic effect of decreased hepatocellular bile salt uptake.	Bile Acids and Salts	201-210	interleukin 1 beta	Homo sapiens	83-91
10642306-5	2000	For this, we measured IL-1beta-stimulated nitrite (NOx) production with use of the Griess reagent, prostaglandin E(2) (PGE(2)) production with use of an enzyme immunoassay, and arachidonic acid release in the presence and absence of BEL.	nicotine 1-N-oxide	51-54	interleukin 1 beta	Homo sapiens	22-30
10642313-7	2000	Long-term treatment with thapsigargin, which depletes intracellular Ca(2+) stores, decreased basal promoter activity and blocked the effect of IL-1beta.	Thapsigargin	25-37	interleukin 1 beta	Homo sapiens	143-151
10642306-7	2000	Treatment with IL-1beta (5 ng/mL) for 24 hours stimulated NOx production by 8-fold and iNOS protein levels by at least 10-fold.	nicotine 1-N-oxide	58-61	interleukin 1 beta	Homo sapiens	15-23
10642306-4	2000	We tested whether iPLA(2) metabolites are involved in the regulation by IL-1beta of iNOS with the use of bromoenol lactone (BEL), a specific and irreversible inhibitor of iPLA(2).	ipla	18-22	interleukin 1 beta	Homo sapiens	72-80
10642306-9	2000	When neonatal ventricular myocytes were treated with 10 micromol/L BEL, both IL-1beta-stimulated PGE(2) production and arachidonic acid release were inhibited.	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	67-70	interleukin 1 beta	Homo sapiens	77-85
10642306-9	2000	When neonatal ventricular myocytes were treated with 10 micromol/L BEL, both IL-1beta-stimulated PGE(2) production and arachidonic acid release were inhibited.	Prostaglandins E	97-100	interleukin 1 beta	Homo sapiens	77-85
10642306-10	2000	BEL inhibited IL-1beta-stimulated NOx production and iNOS protein by 88% and 93%, respectively.	nicotine 1-N-oxide	34-37	interleukin 1 beta	Homo sapiens	14-22
10642306-5	2000	For this, we measured IL-1beta-stimulated nitrite (NOx) production with use of the Griess reagent, prostaglandin E(2) (PGE(2)) production with use of an enzyme immunoassay, and arachidonic acid release in the presence and absence of BEL.	Nitrites	42-49	interleukin 1 beta	Homo sapiens	22-30
10642306-12	2000	Our results indicate that an iPLA(2) metabolite, perhaps lysophosphatidic acid, may be involved in the IL-1beta-signaling pathway, regulating the synthesis of iNOS.	lysophosphatidic acid	57-78	interleukin 1 beta	Homo sapiens	103-111
11729854-10	2000	PGE2 production by the human cell line was increased by LPS, IL-1 and Ca Ion.	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	61-65
10603404-9	2000	In contrast to the response to LPS, where TNF-alpha, IL-1beta, IL-6, and IL-8 appear almost simultaneously, the human monocyte response to GBS results in the production of TNF-alpha but delayed appearance of IL-1beta, IL-6, and IL-8.	gbs	139-142	interleukin 1 beta	Homo sapiens	208-216
11240649-0	2000	Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel.	Paclitaxel	149-159	interleukin 1 beta	Homo sapiens	10-18
10651950-7	2000	Combinations of TGF-beta1 with IL-1beta also increased PGE2 output and caused appropriate changes in prostaglandin pathway enzymes, whereas TGF-beta1 and IL-1alpha had more limited effects.	Dinoprostone	55-59	interleukin 1 beta	Homo sapiens	31-39
10651950-7	2000	Combinations of TGF-beta1 with IL-1beta also increased PGE2 output and caused appropriate changes in prostaglandin pathway enzymes, whereas TGF-beta1 and IL-1alpha had more limited effects.	Prostaglandins	101-114	interleukin 1 beta	Homo sapiens	31-39
11729854-14	2000	In human intestinal epithelial cells, LPS production of PGE2 proceeds through a pathway associated with sPLA2 generated arachidonic acid while IL-1 stimulated PGE2 is produced by arachidonic acid generated by cPLA2.	Dinoprostone	159-163	interleukin 1 beta	Homo sapiens	143-147
11729854-11	2000	IL-1 and Ca Ion stimulated PGE2 formation was inhibited by the cPLA2 enzyme inhibitors while LPS stimulated PGE2 production was not inhibited by the cPLA2 inhibitor; but was inhibited by the sPLA2 enzyme inhibitor.	Dinoprostone	27-31	interleukin 1 beta	Homo sapiens	0-4
11729854-14	2000	In human intestinal epithelial cells, LPS production of PGE2 proceeds through a pathway associated with sPLA2 generated arachidonic acid while IL-1 stimulated PGE2 is produced by arachidonic acid generated by cPLA2.	Arachidonic Acid	179-195	interleukin 1 beta	Homo sapiens	143-147
10646728-4	2000	RESULTS: Northern blot analysis revealed that clarithromycin suppressed IL-1 beta gene expression in human nasal epithelial cells stimulated by H. influenzae endotoxin (HIE).	Clarithromycin	46-60	interleukin 1 beta	Homo sapiens	72-81
11106302-3	2000	Treatment of highly purified microglial cell cultures with morphine (10(-8)-10(-6) M) potently inhibited RANTES production by lipopolysaccharide- and interleukin-1beta-stimulated cells.	Morphine	59-67	interleukin 1 beta	Homo sapiens	150-167
10605036-4	2000	Pretreatment with the PI 3-kinase inhibitors, wortmannin and LY294002, effectively blocked fMLP-induced IL-1beta gene expression as well as NF-kappaB activation.	Wortmannin	46-56	interleukin 1 beta	Homo sapiens	104-112
10605036-4	2000	Pretreatment with the PI 3-kinase inhibitors, wortmannin and LY294002, effectively blocked fMLP-induced IL-1beta gene expression as well as NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	interleukin 1 beta	Homo sapiens	104-112
10646728-5	2000	Intercellular adhesion molecule-1 gene expression in nasal fibroblasts stimulated by IL-1 beta was also suppressed by clarithromycin.	Clarithromycin	118-132	interleukin 1 beta	Homo sapiens	85-94
10646728-6	2000	Furthermore, electrophoretic mobility shift assay demonstrated that clarithromycin reduced DNA-binding activity of NF-kappa B in both human nasal epithelial cells and fibroblasts stimulated by HIE or IL-1 beta, respectively.	Clarithromycin	68-82	interleukin 1 beta	Homo sapiens	200-209
10724331-1	2000	Interleukin-1beta (IL-1) is a potent inducer of cyclooxygenase-2 (COX-2) and prostaglandin biosynthesis in many types of cells, yet little is known about the molecular mechanisms regulating IL-1 mediated prostanoid biosynthesis in the endothelium of the microvasculature.	Prostaglandins	77-90	interleukin 1 beta	Homo sapiens	0-17
11132768-7	2000	In contrast, DEX inhibited IL-1beta-induced PLA2 activity but not constitutive activity.	Dexamethasone	13-16	interleukin 1 beta	Homo sapiens	27-35
11132768-8	2000	DEX but not annexin I peptide inhibited IL-1beta-induced PGE2 release.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	40-48
11132768-8	2000	DEX but not annexin I peptide inhibited IL-1beta-induced PGE2 release.	Dinoprostone	57-61	interleukin 1 beta	Homo sapiens	40-48
11132768-11	2000	DEX exerted a concentration-dependent inhibition of IL-1beta-induced but not constitutive COX activity.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	52-60
11132773-2	2000	Interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) induce ASMC to release inflammatory mediators in vitro.	asmc	81-85	interleukin 1 beta	Homo sapiens	0-17
11132773-2	2000	Interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) induce ASMC to release inflammatory mediators in vitro.	asmc	81-85	interleukin 1 beta	Homo sapiens	19-27
11132773-4	2000	We determined whether; (1) allergic asthmatic serum (AAS) modulates ASMC mediator release in response to IL-1beta and TNF-alpha, and (2) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS.	asmc	68-72	interleukin 1 beta	Homo sapiens	105-113
11132773-4	2000	We determined whether; (1) allergic asthmatic serum (AAS) modulates ASMC mediator release in response to IL-1beta and TNF-alpha, and (2) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS.	asmc	162-166	interleukin 1 beta	Homo sapiens	137-145
11132773-6	2000	IL-1beta and TNF-alpha induced GM-CSF release in ASMC pre-incubated with AAS was not greater than that in ASMC pre-incubated with NAS or Monomed.	asmc	49-53	interleukin 1 beta	Homo sapiens	0-8
11132773-7	2000	IL-1beta and TNF-alpha, however, primed ASMC to release GM-CSF in response to human serum.	asmc	40-44	interleukin 1 beta	Homo sapiens	0-8
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Genistein	32-41	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Tyrphostins	46-56	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	AG 127	57-62	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Phosphatidylcholines	68-87	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	tricyclodecane-9-yl-xanthogenate	115-120	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Dinoprostone	149-167	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Prostaglandins E	169-172	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	215-222	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Phosphatidylinositols	226-246	interleukin 1 beta	Homo sapiens	132-140
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Propranolol	278-289	interleukin 1 beta	Homo sapiens	132-140
10724331-1	2000	Interleukin-1beta (IL-1) is a potent inducer of cyclooxygenase-2 (COX-2) and prostaglandin biosynthesis in many types of cells, yet little is known about the molecular mechanisms regulating IL-1 mediated prostanoid biosynthesis in the endothelium of the microvasculature.	Prostaglandins	77-90	interleukin 1 beta	Homo sapiens	19-23
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	phosphatidate	293-306	interleukin 1 beta	Homo sapiens	132-140
10724331-1	2000	Interleukin-1beta (IL-1) is a potent inducer of cyclooxygenase-2 (COX-2) and prostaglandin biosynthesis in many types of cells, yet little is known about the molecular mechanisms regulating IL-1 mediated prostanoid biosynthesis in the endothelium of the microvasculature.	Prostaglandins	204-214	interleukin 1 beta	Homo sapiens	0-17
10617676-4	2000	The PKC inhibitors (Go 6976 and Ro 31-8220) and NF-kappaB inhibitor, pyrrolidine dithiocarbamate, also attenuated IL-1beta-induced PGE(2) release and COX-2 expression.	pyrrolidine dithiocarbamic acid	69-96	interleukin 1 beta	Homo sapiens	114-122
10617676-4	2000	The PKC inhibitors (Go 6976 and Ro 31-8220) and NF-kappaB inhibitor, pyrrolidine dithiocarbamate, also attenuated IL-1beta-induced PGE(2) release and COX-2 expression.	Prostaglandins E	131-134	interleukin 1 beta	Homo sapiens	114-122
10617676-10	2000	These results indicate that in human pulmonary epithelial cells, IL-1beta might activate phosphatidylcholine-phospholipase C through an upstream tyrosine phosphorylation to elicit PKC activation, which in turn initiates NF-kappaB activation, and finally induces COX-2 expression and PGE(2) release.	Tyrosine	145-153	interleukin 1 beta	Homo sapiens	65-73
10754403-4	2000	The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine, blocked IL-1beta-mediated inhibition of glutamate uptake, suggesting involvement of nitric oxide in the effect of IL-1beta.	Nitric Oxide	4-16	interleukin 1 beta	Homo sapiens	73-81
10724331-1	2000	Interleukin-1beta (IL-1) is a potent inducer of cyclooxygenase-2 (COX-2) and prostaglandin biosynthesis in many types of cells, yet little is known about the molecular mechanisms regulating IL-1 mediated prostanoid biosynthesis in the endothelium of the microvasculature.	Prostaglandins	204-214	interleukin 1 beta	Homo sapiens	19-23
10754403-4	2000	The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine, blocked IL-1beta-mediated inhibition of glutamate uptake, suggesting involvement of nitric oxide in the effect of IL-1beta.	Nitric Oxide	4-16	interleukin 1 beta	Homo sapiens	179-187
10754403-4	2000	The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine, blocked IL-1beta-mediated inhibition of glutamate uptake, suggesting involvement of nitric oxide in the effect of IL-1beta.	omega-N-Methylarginine	37-63	interleukin 1 beta	Homo sapiens	73-81
10724331-3	2000	IL-1 enhanced steady state levels of COX-2 protein and mRNA synthesis by approximately 2-fold which preceded a 2-fold increase in PGF(alpha) biosynthesis.	Prostaglandins F	130-133	interleukin 1 beta	Homo sapiens	0-4
10754403-4	2000	The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine, blocked IL-1beta-mediated inhibition of glutamate uptake, suggesting involvement of nitric oxide in the effect of IL-1beta.	omega-N-Methylarginine	37-63	interleukin 1 beta	Homo sapiens	179-187
10617676-10	2000	These results indicate that in human pulmonary epithelial cells, IL-1beta might activate phosphatidylcholine-phospholipase C through an upstream tyrosine phosphorylation to elicit PKC activation, which in turn initiates NF-kappaB activation, and finally induces COX-2 expression and PGE(2) release.	Prostaglandins E	283-286	interleukin 1 beta	Homo sapiens	65-73
10754403-4	2000	The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine, blocked IL-1beta-mediated inhibition of glutamate uptake, suggesting involvement of nitric oxide in the effect of IL-1beta.	Glutamic Acid	105-114	interleukin 1 beta	Homo sapiens	73-81
10765972-2	2000	Treatment of trophoblast cells in primary culture with interleukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha) resulted in decreased prostaglandin metabolizing activity.	Prostaglandins	150-163	interleukin 1 beta	Homo sapiens	55-72
10754403-4	2000	The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine, blocked IL-1beta-mediated inhibition of glutamate uptake, suggesting involvement of nitric oxide in the effect of IL-1beta.	Glutamic Acid	105-114	interleukin 1 beta	Homo sapiens	179-187
10754403-4	2000	The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine, blocked IL-1beta-mediated inhibition of glutamate uptake, suggesting involvement of nitric oxide in the effect of IL-1beta.	Nitric Oxide	149-161	interleukin 1 beta	Homo sapiens	73-81
10754403-4	2000	The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine, blocked IL-1beta-mediated inhibition of glutamate uptake, suggesting involvement of nitric oxide in the effect of IL-1beta.	Nitric Oxide	149-161	interleukin 1 beta	Homo sapiens	179-187
10754403-6	2000	The anti-inflammatory cytokine IFN-beta blocked cytokine (IL-1beta plus IFN-gamma)-induced inhibition of glutamate uptake with a corresponding reduction in nitric oxide generation.	Glutamic Acid	105-114	interleukin 1 beta	Homo sapiens	58-66
10754403-6	2000	The anti-inflammatory cytokine IFN-beta blocked cytokine (IL-1beta plus IFN-gamma)-induced inhibition of glutamate uptake with a corresponding reduction in nitric oxide generation.	Nitric Oxide	156-168	interleukin 1 beta	Homo sapiens	58-66
10930355-6	2000	The inhibitory effect of SR 59119A was (1) abolished by an incubation of HIB with pertussis toxin (1 microg/ml, during 15 h in Krebs-Henseleit solution, at 21 degrees C), which is known to inactivate the Gi protein and (2) increased after an incubation of HIB with the pro-inflammatory cytokine IL-1beta (10 ng/ml, during 15 h in Krebs-Henseleit solution, at 21 degrees C), which is known to up-regulate Gi protein expression.	SR 59119A	25-34	interleukin 1 beta	Homo sapiens	295-303
10765972-2	2000	Treatment of trophoblast cells in primary culture with interleukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha) resulted in decreased prostaglandin metabolizing activity.	Prostaglandins	150-163	interleukin 1 beta	Homo sapiens	74-82
10765973-1	2000	We have determined that prostaglandin H synthase-2 localises strongly to the nuclear membrane as well as being found in the endoplasmic reticulum in human amnion-derived WISH cells which have been stimulated with interleukin 1beta and phorbol ester.	Prostaglandins	24-37	interleukin 1 beta	Homo sapiens	213-230
10930355-6	2000	The inhibitory effect of SR 59119A was (1) abolished by an incubation of HIB with pertussis toxin (1 microg/ml, during 15 h in Krebs-Henseleit solution, at 21 degrees C), which is known to inactivate the Gi protein and (2) increased after an incubation of HIB with the pro-inflammatory cytokine IL-1beta (10 ng/ml, during 15 h in Krebs-Henseleit solution, at 21 degrees C), which is known to up-regulate Gi protein expression.	HIB	73-76	interleukin 1 beta	Homo sapiens	295-303
10587350-0	1999	Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production.	Nitric Oxide	70-82	interleukin 1 beta	Homo sapiens	48-65
10638662-6	2000	Serine protease inhibition by tosyl-lysine-chloromethylketone and tosyl-phenylalanine-chloromethylketone inhibited IkappaBalpha degradation and NF-kappaB activation stimulated by IL-1beta.	Tosyllysine Chloromethyl Ketone	30-61	interleukin 1 beta	Homo sapiens	179-187
10638662-6	2000	Serine protease inhibition by tosyl-lysine-chloromethylketone and tosyl-phenylalanine-chloromethylketone inhibited IkappaBalpha degradation and NF-kappaB activation stimulated by IL-1beta.	Tosylphenylalanyl Chloromethyl Ketone	66-104	interleukin 1 beta	Homo sapiens	179-187
10601248-4	1999	Two nonselective alkylating agents, N-ethylmaleimide and phenylarsine oxide, also blocked maturation and release of pro-IL-1beta.	Ethylmaleimide	36-52	interleukin 1 beta	Homo sapiens	116-128
10601248-4	1999	Two nonselective alkylating agents, N-ethylmaleimide and phenylarsine oxide, also blocked maturation and release of pro-IL-1beta.	oxophenylarsine	57-75	interleukin 1 beta	Homo sapiens	116-128
10601248-5	1999	Two inhibitors of anion transport, glyburide and ethacrynic acid, blocked maturation of both caspase-1 and pro-IL-1beta and prevented release of the propolypeptides.	Glyburide	35-44	interleukin 1 beta	Homo sapiens	107-119
10601248-5	1999	Two inhibitors of anion transport, glyburide and ethacrynic acid, blocked maturation of both caspase-1 and pro-IL-1beta and prevented release of the propolypeptides.	Ethacrynic Acid	49-64	interleukin 1 beta	Homo sapiens	107-119
10624546-2	1999	In the present investigation, we assessed whether the elevated IL-1 beta production in dysthymic patients would normalize following treatment with sertraline.	Sertraline	147-157	interleukin 1 beta	Homo sapiens	63-72
10595927-15	1999	Our study demonstrates that HPMCs synthesize and release significant amounts of bFGF and that the expression of this growth factor is significantly up-regulated by the proinflammatory cytokine IL-1beta.	hpmcs	28-33	interleukin 1 beta	Homo sapiens	193-201
10616000-9	1999	In the cells prestimulated with IL-1beta for 24 hours, Tau-Cl still inhibited synthesis of IL-6, but did not affect IL-8 production.	tau-cl	55-61	interleukin 1 beta	Homo sapiens	32-40
10559516-4	1999	Enrichment of HAEC with the same doses of vitamin E suppressed IL-1beta-stimulated expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule-1 (E-selectin).	Vitamin E	42-51	interleukin 1 beta	Homo sapiens	63-71
10559516-6	1999	However, IL-1beta-induced productions of both MCP-1 and IL-8 were dose-dependently suppressed by enrichment of cells with vitamin E.	Vitamin E	122-131	interleukin 1 beta	Homo sapiens	9-17
10559516-7	1999	Vitamin E, at the doses used, did not significantly change the spontaneous production but dose-dependently inhibited the IL-1beta-induced production of inflammatory cytokine IL-6.	Vitamin E	0-9	interleukin 1 beta	Homo sapiens	121-129
10616001-9	1999	Fluoxetine and amitriptyline (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) also significantly (P&lt;0.05) inhibited HA production by human synovial cells in the presence of IL-1beta plus TNFalpha.	Fluoxetine	0-10	interleukin 1 beta	Homo sapiens	173-181
10616001-9	1999	Fluoxetine and amitriptyline (0.3 microg/ml, 1 microg/ml, and 3 microg/ml) also significantly (P&lt;0.05) inhibited HA production by human synovial cells in the presence of IL-1beta plus TNFalpha.	Amitriptyline	15-28	interleukin 1 beta	Homo sapiens	173-181
10616001-10	1999	Fluoxetine and amitriptyline (1 microg/ml) partially reversed IL-1beta-induced inhibition of 35S-GAG synthesis by human cartilage cultures (P&lt;0.05).	Fluoxetine	0-10	interleukin 1 beta	Homo sapiens	62-70
10616001-10	1999	Fluoxetine and amitriptyline (1 microg/ml) partially reversed IL-1beta-induced inhibition of 35S-GAG synthesis by human cartilage cultures (P&lt;0.05).	Amitriptyline	15-28	interleukin 1 beta	Homo sapiens	62-70
10616001-10	1999	Fluoxetine and amitriptyline (1 microg/ml) partially reversed IL-1beta-induced inhibition of 35S-GAG synthesis by human cartilage cultures (P&lt;0.05).	Sulfur-35	93-96	interleukin 1 beta	Homo sapiens	62-70
10616001-10	1999	Fluoxetine and amitriptyline (1 microg/ml) partially reversed IL-1beta-induced inhibition of 35S-GAG synthesis by human cartilage cultures (P&lt;0.05).	Glycosaminoglycans	97-100	interleukin 1 beta	Homo sapiens	62-70
10630489-1	1999	We investigated the effects of 16,16-dimethyl prostaglandin E2 on the production of tumor necrosis factor-alpha and interleukin-1beta in human monocytes stimulated with Helicobacter pylori.	16,16-Dimethylprostaglandin E2	31-62	interleukin 1 beta	Homo sapiens	116-133
10620064-7	1999	Here, we demonstrate that zoledronate significantly inhibits MMP-1 production by BMSCs stimulated with IL-1beta more efficiently than pamidronate.	Zoledronic Acid	26-37	interleukin 1 beta	Homo sapiens	103-111
10786823-7	1999	The IL-1b effect proved to be protein biosynthesis and eicosanoid dependent, nitric oxide independent, and relatively specific in that it was not reproduced by a select series of other granulosa cell agonists.	Eicosanoids	55-65	interleukin 1 beta	Homo sapiens	4-9
10786823-7	1999	The IL-1b effect proved to be protein biosynthesis and eicosanoid dependent, nitric oxide independent, and relatively specific in that it was not reproduced by a select series of other granulosa cell agonists.	Nitric Oxide	77-89	interleukin 1 beta	Homo sapiens	4-9
10593617-0	1999	IL-1beta increases intracellular calcium through an IL-1 type 1 receptor mediated mechanism in C6 astrocytic cells.	Calcium	33-40	interleukin 1 beta	Homo sapiens	0-8
10599732-8	1999	IL-1beta increased PGHS-2 mRNA and PGE2 output from villous and chorion trophoblasts and decreased PGDH mRNA in villous trophoblasts (all P &lt; 0.05).	Dinoprostone	35-39	interleukin 1 beta	Homo sapiens	0-8
10600352-5	1999	Pretreatment with n-3 FA, 20:5 and 22:6 at 10 microM, resulted in time-dependent suppression of not only TF activation but also the elicitation of NO, TNF-alpha, and IL-1beta.	Fatty Acids, Omega-3	18-24	interleukin 1 beta	Homo sapiens	166-174
10614837-8	1999	In the animals treated with 1 mg/kg digoxin, IL-1beta was significantly higher than in the control group.	Digoxin	36-43	interleukin 1 beta	Homo sapiens	45-53
10632517-14	1999	Furthermore, these studies indicate that elevated triglycerides are able to modulate IL-1beta production by PMNs stimulated with P. gingivalis LPS.	Triglycerides	50-63	interleukin 1 beta	Homo sapiens	85-93
10588509-1	1999	Studies performed on healthy volunteers have revealed that catecholamines down-regulate the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)alpha, interleukin (IL)-6, and IL-1beta.	Catecholamines	59-73	interleukin 1 beta	Homo sapiens	197-205
10698316-1	1999	In previous research, we were able to demonstrate that a seven amino acid residue peptide (VITFFSL), designed as an antisense peptide of the beta-bulge trigger loop region of interleukin 1beta (IL-1beta) (QGEESND; residues 48-54 [mature protein sequence]), was able to interact with IL-1 specifically and inhibit the response to IL-1 in an in vitro bioassay.	vitffsl	91-98	interleukin 1 beta	Homo sapiens	175-192
10698316-1	1999	In previous research, we were able to demonstrate that a seven amino acid residue peptide (VITFFSL), designed as an antisense peptide of the beta-bulge trigger loop region of interleukin 1beta (IL-1beta) (QGEESND; residues 48-54 [mature protein sequence]), was able to interact with IL-1 specifically and inhibit the response to IL-1 in an in vitro bioassay.	vitffsl	91-98	interleukin 1 beta	Homo sapiens	194-202
10698316-1	1999	In previous research, we were able to demonstrate that a seven amino acid residue peptide (VITFFSL), designed as an antisense peptide of the beta-bulge trigger loop region of interleukin 1beta (IL-1beta) (QGEESND; residues 48-54 [mature protein sequence]), was able to interact with IL-1 specifically and inhibit the response to IL-1 in an in vitro bioassay.	vitffsl	91-98	interleukin 1 beta	Homo sapiens	194-198
10698316-1	1999	In previous research, we were able to demonstrate that a seven amino acid residue peptide (VITFFSL), designed as an antisense peptide of the beta-bulge trigger loop region of interleukin 1beta (IL-1beta) (QGEESND; residues 48-54 [mature protein sequence]), was able to interact with IL-1 specifically and inhibit the response to IL-1 in an in vitro bioassay.	vitffsl	91-98	interleukin 1 beta	Homo sapiens	283-287
10588509-6	1999	In blood of healthy volunteers, epinephrine reduced the LPS-stimulated synthesis of TNFalpha by 62.5% (P&lt; 0.0001), of IL-6 by 39% (P&lt; 0.0001), and of IL-1beta by 40% (P= 0.015), and increased the LPS-stimulated IL-10 production by 77.8% (P &lt; 0.0001).	Epinephrine	32-43	interleukin 1 beta	Homo sapiens	156-164
10588509-9	1999	Interestingly, epinephrine suppressed the IL-1beta production by 73% (P &lt; 0.0001) in blood of patients in prolonged septic shock, which was twice as much as in blood samples of healthy volunteers.	Epinephrine	15-26	interleukin 1 beta	Homo sapiens	42-50
10559138-0	1999	Increase in prostaglandin E(2) production by interleukin-1beta in arterial smooth muscle cells derived from patients with moyamoya disease.	Dinoprostone	12-30	interleukin 1 beta	Homo sapiens	45-62
10594346-0	1999	Auranofin inhibits interleukin-1beta-induced transcript of cyclooxygenase-2 on cultured human synoviocytes.	Auranofin	0-9	interleukin 1 beta	Homo sapiens	19-36
10594346-7	1999	Auranofin attenuated interleukin-1beta-induced prostaglandin E(2) production of the cells in a dose-dependent fashion.	Auranofin	0-9	interleukin 1 beta	Homo sapiens	21-38
10594346-7	1999	Auranofin attenuated interleukin-1beta-induced prostaglandin E(2) production of the cells in a dose-dependent fashion.	Dinoprostone	47-65	interleukin 1 beta	Homo sapiens	21-38
10594346-8	1999	Auranofin selectively suppressed interleukin-1beta-induced cyclooxygenase-2 mRNA and protein expression of the cells without alteration of cyclooxygenase-1 expression.	Auranofin	0-9	interleukin 1 beta	Homo sapiens	33-50
10594346-9	1999	Also, auranofin interfered with interleukin-1beta-induced translocation of nuclear factor-kappa B.	Auranofin	6-15	interleukin 1 beta	Homo sapiens	32-49
10594346-11	1999	Our data indicate that auranofin inhibits interleukin-1beta-induced prostaglandin E(2) synthesis and cyclooxygenase-2 expression via suppression of nuclear factor-kappa B activation on synoviocytes.	Auranofin	23-32	interleukin 1 beta	Homo sapiens	42-59
10594346-11	1999	Our data indicate that auranofin inhibits interleukin-1beta-induced prostaglandin E(2) synthesis and cyclooxygenase-2 expression via suppression of nuclear factor-kappa B activation on synoviocytes.	Dinoprostone	68-86	interleukin 1 beta	Homo sapiens	42-59
10559138-6	1999	When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ.	Dinoprostone	66-84	interleukin 1 beta	Homo sapiens	36-53
10559138-6	1999	When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ.	Dinoprostone	66-84	interleukin 1 beta	Homo sapiens	55-63
10559138-6	1999	When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ.	Prostaglandins E	86-89	interleukin 1 beta	Homo sapiens	36-53
10559138-6	1999	When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ.	Prostaglandins E	86-89	interleukin 1 beta	Homo sapiens	55-63
10559138-6	1999	When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ.	Epoprostenol	210-222	interleukin 1 beta	Homo sapiens	36-53
10559138-6	1999	When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ.	Epoprostenol	210-222	interleukin 1 beta	Homo sapiens	55-63
10559138-6	1999	When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ.	thromboxane b	227-240	interleukin 1 beta	Homo sapiens	36-53
10559138-6	1999	When the cells were stimulated with interleukin-1beta (IL-1beta), prostaglandin E(2) (PGE(2)) release into the medium was significantly greater from moyamoya SMCs than from control SMCs, whereas the amounts of prostacyclin and thromboxane B(2) did not differ.	thromboxane b	227-240	interleukin 1 beta	Homo sapiens	55-63
10559138-7	1999	IL-1beta-induced PGE(2) production by moyamoya SMCs was completely blocked by the addition of indomethacin or NS-398.	Prostaglandins E	17-20	interleukin 1 beta	Homo sapiens	0-8
10559138-7	1999	IL-1beta-induced PGE(2) production by moyamoya SMCs was completely blocked by the addition of indomethacin or NS-398.	Indomethacin	94-106	interleukin 1 beta	Homo sapiens	0-8
10559138-7	1999	IL-1beta-induced PGE(2) production by moyamoya SMCs was completely blocked by the addition of indomethacin or NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	110-116	interleukin 1 beta	Homo sapiens	0-8
10564154-8	1999	In contrast to NAC, the metal chelators pyrrolidine dithiocarbamate and diethyldithiocarbamate attenuated IL-1beta-induced NF-kappaB activation but had no effect on intracellular sulfhydryl content.	Metals	24-29	interleukin 1 beta	Homo sapiens	106-114
10543991-2	1999	We found that KS cell growth factors oncostatin M, sIL-6R/IL-6, TNFalpha, and IL-1beta all activate ERK1/2, and selective blockage of this kinase by PD98059 resulted in a profound inhibition of the cytokine-induced KS cell growth.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	149-156	interleukin 1 beta	Homo sapiens	78-86
10564154-8	1999	In contrast to NAC, the metal chelators pyrrolidine dithiocarbamate and diethyldithiocarbamate attenuated IL-1beta-induced NF-kappaB activation but had no effect on intracellular sulfhydryl content.	pyrrolidine dithiocarbamic acid	40-67	interleukin 1 beta	Homo sapiens	106-114
10564178-4	1999	In addition, Dex had no effect on Iso-stimulated cAMP formation in control cells but prevented the IL-1beta-induced reduction in Iso-stimulated cAMP formation.	Dexamethasone	13-16	interleukin 1 beta	Homo sapiens	99-107
10564179-6	1999	PD-98059 (100 microM) and U-126 (10 microM) each decreased COX-2 expression when administered before IL-1beta treatment.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Homo sapiens	101-109
10564154-8	1999	In contrast to NAC, the metal chelators pyrrolidine dithiocarbamate and diethyldithiocarbamate attenuated IL-1beta-induced NF-kappaB activation but had no effect on intracellular sulfhydryl content.	Ditiocarb	72-94	interleukin 1 beta	Homo sapiens	106-114
10564179-8	1999	In IL-1beta-treated cells, prior administration of PD-98059 caused 81, 92 and 40% decreases in basal and BK- and AA-stimulated PGE(2) release, respectively (P &lt; 0.01), whereas administration of PD-98059 20 h after IL-1beta resulted in only 38 and 43% decreases in basal and BK-stimulated PGE(2) release, respectively (P &lt; 0.02) and had no effect on AA-stimulated PGE(2) release.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	51-59	interleukin 1 beta	Homo sapiens	3-11
10564178-4	1999	In addition, Dex had no effect on Iso-stimulated cAMP formation in control cells but prevented the IL-1beta-induced reduction in Iso-stimulated cAMP formation.	Cyclic AMP	144-148	interleukin 1 beta	Homo sapiens	99-107
10564178-6	1999	Dex and FP also prevented IL-1beta-induced hyporesponsiveness to PGE(2) stimulation.	Dinoprostone	65-71	interleukin 1 beta	Homo sapiens	26-34
10533055-6	1999	Similarly, the effect of the NOS inhibitor, N(G)-monomethyl L-arginine (NMMA) on IL-1beta/IFNgamma-induced neuronal death was variable, showing no statistically significant effect when results from more than 30 independent cultures were averaged.	omega-N-Methylarginine	44-70	interleukin 1 beta	Homo sapiens	81-89
10564178-8	1999	We have previously reported that the IL-1beta effect on beta-adrenergic responsiveness is mediated through cyclooxygenase-2 expression and prostanoid formation.	Prostaglandins	139-149	interleukin 1 beta	Homo sapiens	37-45
10564178-9	1999	Consistent with these observations, IL-1beta-induced cyclooxygenase-2 expression was virtually abolished by FP at concentrations of 10(-10) M and greater, with a resultant decrease in PGE(2) formation.	Prostaglandins E	184-187	interleukin 1 beta	Homo sapiens	36-44
10564179-1	1999	We have previously reported that interleukin (IL)-1beta causes beta-adrenergic hyporesponsiveness in cultured human airway smooth muscle cells by increasing cyclooxygenase-2 (COX-2) expression and prostanoid formation.	Prostaglandins	197-207	interleukin 1 beta	Homo sapiens	33-55
10564179-4	1999	Pretreating cells with the mitogen-activated protein kinase kinase inhibitor PD-98059 or U-126 (2 h before IL-1beta treatment) decreased ERK phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	77-85	interleukin 1 beta	Homo sapiens	107-115
10564179-4	1999	Pretreating cells with the mitogen-activated protein kinase kinase inhibitor PD-98059 or U-126 (2 h before IL-1beta treatment) decreased ERK phosphorylation.	u-126	89-94	interleukin 1 beta	Homo sapiens	107-115
10564179-5	1999	IL-1beta (20 ng/ml for 22 h) alone caused a marked induction of COX-2 and increased basal PGE(2) release 28-fold (P &lt; 0.001).	Prostaglandins E	90-93	interleukin 1 beta	Homo sapiens	0-8
10564179-8	1999	In IL-1beta-treated cells, prior administration of PD-98059 caused 81, 92 and 40% decreases in basal and BK- and AA-stimulated PGE(2) release, respectively (P &lt; 0.01), whereas administration of PD-98059 20 h after IL-1beta resulted in only 38 and 43% decreases in basal and BK-stimulated PGE(2) release, respectively (P &lt; 0.02) and had no effect on AA-stimulated PGE(2) release.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	51-59	interleukin 1 beta	Homo sapiens	217-225
10564179-8	1999	In IL-1beta-treated cells, prior administration of PD-98059 caused 81, 92 and 40% decreases in basal and BK- and AA-stimulated PGE(2) release, respectively (P &lt; 0.01), whereas administration of PD-98059 20 h after IL-1beta resulted in only 38 and 43% decreases in basal and BK-stimulated PGE(2) release, respectively (P &lt; 0.02) and had no effect on AA-stimulated PGE(2) release.	Prostaglandins E	127-130	interleukin 1 beta	Homo sapiens	3-11
10564179-9	1999	IL-1beta attenuated isoproterenol-induced decreases in human airway smooth muscle stiffness as measured by magnetic twisting cytometry, and PD-98059 or U-126 abolished this effect in a concentration-dependent manner.	Isoproterenol	20-33	interleukin 1 beta	Homo sapiens	0-8
10564179-10	1999	These results are consistent with the hypothesis that ERKs are involved early in the signal transduction pathway through which IL-1beta induces PGE(2) synthesis and beta-adrenergic hyporesponsiveness and that ERKs act by inducing COX-2 and activating phospholipase A(2).	Prostaglandins E	144-147	interleukin 1 beta	Homo sapiens	127-135
10585039-7	1999	Interleukin-1beta and interleukin-6 levels after cardiopulmonary bypass were significantly (p &lt; 0.05) lower in the milrinone group than in the control group.	Milrinone	118-127	interleukin 1 beta	Homo sapiens	0-17
10533055-6	1999	Similarly, the effect of the NOS inhibitor, N(G)-monomethyl L-arginine (NMMA) on IL-1beta/IFNgamma-induced neuronal death was variable, showing no statistically significant effect when results from more than 30 independent cultures were averaged.	omega-N-Methylarginine	72-76	interleukin 1 beta	Homo sapiens	81-89
10566653-2	1999	Orbital fibroblasts have been shown to exhibit substantial up-regulation of hyaluronan synthesis when activated with proinflammatory cytokines such as interleukin-1beta (IL-1beta).	Hyaluronic Acid	76-86	interleukin 1 beta	Homo sapiens	151-168
10566679-1	1999	The present investigation examined the effect of interleukin-1beta (IL-1beta) on progesterone production by human luteal cells and the expression and localization of the IL-1 system in the human corpus luteum (CL).	Progesterone	81-93	interleukin 1 beta	Homo sapiens	68-76
10566653-2	1999	Orbital fibroblasts have been shown to exhibit substantial up-regulation of hyaluronan synthesis when activated with proinflammatory cytokines such as interleukin-1beta (IL-1beta).	Hyaluronic Acid	76-86	interleukin 1 beta	Homo sapiens	170-178
10566679-6	1999	The treatment of mixed luteal cells (total luteal cells) with IL-1beta inhibited by 60% hCG-stimulated progesterone production.	Progesterone	103-115	interleukin 1 beta	Homo sapiens	62-70
10527877-1	1999	We found that phorbol ester-primed THP-1 cells (a human monocyte cell line), which express a scavenger receptor, were stimulated by mucins through the macrophage scavenger receptor, resulting in enhanced secretion of IL-1beta.	Phorbol Esters	14-27	interleukin 1 beta	Homo sapiens	217-225
10602303-1	1999	This study examined the applicability of luminol-dependent chemiluminescence (CL) response of neutrophils to assess the degree of stress of spinal surgery by measuring the capacity of circulating neutrophils to produce reactive oxygen species and the levels of serum cytokines: interleukin(IL)-1beta, IL-6, IL-8, tumour necrosis factor (TNF)-alpha and granulocyte colony stimulating factor (G-CSF).	Luminol	41-48	interleukin 1 beta	Homo sapiens	278-299
10565612-7	1999	Additionally, CM-IL1beta, but not control CM, slowed the changes in Mac-1 and CR1 cell surface expression that occurred in HBSS within 2 h of incubation.	hbss	123-127	interleukin 1 beta	Homo sapiens	17-24
10531320-0	1999	Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta.	Prostaglandins E	0-15	interleukin 1 beta	Homo sapiens	63-80
10531320-4	1999	Since we recently observed that IL-1beta induces cyclooxygenase-2 (COX-2) gene expression and PGE(2) synthesis in islet beta cells, we have reassessed the possibility that PGE(2) mediates IL-1beta effects on beta function.	Prostaglandins E	94-97	interleukin 1 beta	Homo sapiens	32-40
10531320-4	1999	Since we recently observed that IL-1beta induces cyclooxygenase-2 (COX-2) gene expression and PGE(2) synthesis in islet beta cells, we have reassessed the possibility that PGE(2) mediates IL-1beta effects on beta function.	Prostaglandins E	172-175	interleukin 1 beta	Homo sapiens	32-40
10531320-6	1999	Both drugs prevented IL-1beta from inducing PGE(2) synthesis and inhibiting insulin secretion; adding back exogenous PGE(2) re-established inhibition of insulin secretion in the presence of IL-1beta.	Prostaglandins E	44-47	interleukin 1 beta	Homo sapiens	21-29
10531320-6	1999	Both drugs prevented IL-1beta from inducing PGE(2) synthesis and inhibiting insulin secretion; adding back exogenous PGE(2) re-established inhibition of insulin secretion in the presence of IL-1beta.	Prostaglandins E	117-120	interleukin 1 beta	Homo sapiens	190-198
10531320-8	1999	We conclude that endogenous PGE(2) mediates the inhibitory effects of exogenous IL-1beta on beta cell function.	Prostaglandins E	28-31	interleukin 1 beta	Homo sapiens	80-88
10687175-1	1999	Modification of the structure of recombinant human IL-1 beta: deletion of the amino acids serine, asparagine, and asparagic acid in position 52-54 in mutant delta SND, led to major changes in its functional activity.	Serine	90-96	interleukin 1 beta	Homo sapiens	51-60
10687175-1	1999	Modification of the structure of recombinant human IL-1 beta: deletion of the amino acids serine, asparagine, and asparagic acid in position 52-54 in mutant delta SND, led to major changes in its functional activity.	Asparagine	98-108	interleukin 1 beta	Homo sapiens	51-60
10687175-1	1999	Modification of the structure of recombinant human IL-1 beta: deletion of the amino acids serine, asparagine, and asparagic acid in position 52-54 in mutant delta SND, led to major changes in its functional activity.	Aspartic Acid	114-128	interleukin 1 beta	Homo sapiens	51-60
10515888-0	1999	Phenylarsine oxide blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells.	oxophenylarsine	0-18	interleukin 1 beta	Homo sapiens	26-43
10515888-5	1999	We found that PAO inhibited the proliferation of both OCIM2 and OCI/AML3 cells in a dose-dependent fashion (0.01 to 0.1 micromol/L) and that IL-1beta partially reversed this inhibitory effect.	oxophenylarsine	14-17	interleukin 1 beta	Homo sapiens	141-149
10515888-6	1999	We then measured IL-1beta levels in these cells by using an enzyme-linked immunosorbent assay and Western immunoblotting and found that PAO almost completely abolished the production of IL-1beta in these AML cells, whereas it did not affect the production of IL-1 receptor antagonist.	oxophenylarsine	136-139	interleukin 1 beta	Homo sapiens	17-25
10515888-6	1999	We then measured IL-1beta levels in these cells by using an enzyme-linked immunosorbent assay and Western immunoblotting and found that PAO almost completely abolished the production of IL-1beta in these AML cells, whereas it did not affect the production of IL-1 receptor antagonist.	oxophenylarsine	136-139	interleukin 1 beta	Homo sapiens	186-194
10523409-3	1999	Cycloheximide (10 microg ml-1, 6 h) blocked IL-1beta-induced COX-2 protein expression and super-induced COX-2 mRNA expression.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	44-52
10523409-6	1999	IL-1beta-induced COX-2 expression was accompanied by a 3-fold increase of prostaglandin E2 release into the culture medium.	Dinoprostone	74-90	interleukin 1 beta	Homo sapiens	0-8
10523409-14	1999	Exposure of cells to SB 203580 (10 microM during only the first 30 min of IL-1beta stimulation was effective in blocking COX-2 protein expression assayed after 6 h in culture.	SB 203580	21-30	interleukin 1 beta	Homo sapiens	74-82
10523409-17	1999	Induction of COX-2 by IL-1beta in HMSMCs provides support for the hypothesis that autocrine prostaglandin signalling in the myometrium, initiated by elevated intrauterine cytokine concentrations, plays a role in regulating myometrial contractility during labour.	Prostaglandins	92-105	interleukin 1 beta	Homo sapiens	22-30
10527877-5	1999	When phorbol ester-primed THP-1 cells were cocultured with colon cancer cells producing mucins, IL-1beta secreted from the THP-1 cells increased significantly.	Phorbol Esters	5-18	interleukin 1 beta	Homo sapiens	96-104
10524680-2	1999	METHODS: Recombinant human IL-1beta and NOS inhibitors with different selectivity for inducible NOS (N-monomethyl-L-arginine [L-NMA], N-iminoethyl-L-ornithine [L-NIO], and S-methylisothiourea [SMT]) were simultaneously administered in rats by a single intraarticular injection in each knee.	omega-N-Methylarginine	101-124	interleukin 1 beta	Homo sapiens	27-35
10516167-4	1999	Levels of IL-1alpha and IL-1beta mRNA increased in human VSMC after 24-48 h of incubation in low O(2) compared with levels in normoxic cells and then decreased upon subsequent reoxygenation.	Oxygen	97-101	interleukin 1 beta	Homo sapiens	24-32
10530917-4	1999	IL-1 beta concentrations increased by 2.6, 2.7 and 7.5 times those of the control in groups treated with 1 microM nicotine, arecoline or with both, respectively.	Nicotine	114-122	interleukin 1 beta	Homo sapiens	0-9
10530917-4	1999	IL-1 beta concentrations increased by 2.6, 2.7 and 7.5 times those of the control in groups treated with 1 microM nicotine, arecoline or with both, respectively.	Arecoline	124-133	interleukin 1 beta	Homo sapiens	0-9
10516217-6	1999	Phentolamine pretreatment also significantly attenuated the shock-mediated increase of IL-1beta concentration in the lung.	Phentolamine	0-12	interleukin 1 beta	Homo sapiens	87-95
10573218-0	1999	Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity.	Procaterol	0-10	interleukin 1 beta	Homo sapiens	20-28
10513835-6	1999	However, interleukin-1beta and interleukin-6 concentrations tended to decrease after treatment with Nilvadipine.	nilvadipine	100-111	interleukin 1 beta	Homo sapiens	9-26
10562909-3	1999	METHODS: Elaboration of fibrinolytic system proteins by HCME exposed either to interleukin-1 beta or to tumor necrosis factor-alpha (TNF) in serum-free medium for 24 h was characterized.	hcme	56-60	interleukin 1 beta	Homo sapiens	79-97
10573218-6	1999	Procaterol and theophylline directly inhibited eosinophil migration to IL-1beta and TNF-alpha-conditioned medium.	Procaterol	0-10	interleukin 1 beta	Homo sapiens	71-79
10573218-6	1999	Procaterol and theophylline directly inhibited eosinophil migration to IL-1beta and TNF-alpha-conditioned medium.	Theophylline	15-27	interleukin 1 beta	Homo sapiens	71-79
10537260-9	1999	Using 40 X 10(8) PE particles (0.7 x 10(8) titanium particles) and 10(6) MLC, the maximal release of IL-1beta was about 20-fold (7-fold titanium particles) higher than that of the rotating control sample.	Polyethylene	17-19	interleukin 1 beta	Homo sapiens	101-109
10541915-8	1999	RESULTS: Concentrations of ILs were significantly elevated after exposure to 200 ppm 1,1,1-trichloroethane (IL-1beta 82.4 vs. 28.8 pg/ml (medians), P=0.003; IL-6 12.2 vs. 7.2 pg/ml, P=0.	1,1,1-trichloroethane	85-106	interleukin 1 beta	Homo sapiens	108-116
10400887-8	1999	Titanium wear debris induced monocyte secretion of IL-1beta at levels comparable to those induced by PWM alone.	Titanium	0-8	interleukin 1 beta	Homo sapiens	51-59
10400887-9	1999	In combination with PWM, titanium wear debris stimulated monocytes to secrete higher concentrations of IL-1beta than is stimulated by titanium itself or by PWM alone.	Titanium	25-33	interleukin 1 beta	Homo sapiens	103-111
10400887-9	1999	In combination with PWM, titanium wear debris stimulated monocytes to secrete higher concentrations of IL-1beta than is stimulated by titanium itself or by PWM alone.	Titanium	134-142	interleukin 1 beta	Homo sapiens	103-111
10479149-4	1999	Pretreatment of HBMECs with tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, n-butyric acid, or a cAMP analogue resulted in a 103- to 104-fold decrease in CD50 values and a 2- to 4-fold increase in fluoresceinated Stx binding to HBMECs.	fluoresceinated stx	208-227	interleukin 1 beta	Homo sapiens	63-85
10479149-6	1999	TNF-alpha and IL-1beta treatment was associated with the increased HBMEC expression of the toxin-binding glycolipid globotriaosylceramide.	Glycolipids	105-115	interleukin 1 beta	Homo sapiens	14-22
10479149-6	1999	TNF-alpha and IL-1beta treatment was associated with the increased HBMEC expression of the toxin-binding glycolipid globotriaosylceramide.	globotriaosylceramide	116-137	interleukin 1 beta	Homo sapiens	14-22
10479156-0	1999	Amphotericin B-induced interleukin-1beta expression in human monocytic cells is calcium and calmodulin dependent.	Amphotericin B	0-14	interleukin 1 beta	Homo sapiens	23-40
10479156-3	1999	Amphotericin B-induced transcription and expression of interleukin (IL)-1beta by human monocytes is believed to be involved in mediating infusion-related adverse effects.	Amphotericin B	0-14	interleukin 1 beta	Homo sapiens	55-77
10479156-4	1999	It is shown here that agents that increase intracellular calcium [Ca++]i (A23187 and thapsigargin) in human monocytic cells also induce IL-1beta expression.	Calcium	57-64	interleukin 1 beta	Homo sapiens	136-144
10479156-4	1999	It is shown here that agents that increase intracellular calcium [Ca++]i (A23187 and thapsigargin) in human monocytic cells also induce IL-1beta expression.	Calcimycin	74-80	interleukin 1 beta	Homo sapiens	136-144
10479156-4	1999	It is shown here that agents that increase intracellular calcium [Ca++]i (A23187 and thapsigargin) in human monocytic cells also induce IL-1beta expression.	Thapsigargin	85-97	interleukin 1 beta	Homo sapiens	136-144
10479156-5	1999	Furthermore, amphotericin B-induced IL-1beta expression is attenuated by the calmodulin antagonist calmidazolium.	Amphotericin B	13-27	interleukin 1 beta	Homo sapiens	36-44
10479156-5	1999	Furthermore, amphotericin B-induced IL-1beta expression is attenuated by the calmodulin antagonist calmidazolium.	calmidazolium	99-112	interleukin 1 beta	Homo sapiens	36-44
10479156-7	1999	In the presence of a nominal calcium buffer or EGTA, amphotericin B-induced IL-1beta expression is attenuated.	Calcium	29-36	interleukin 1 beta	Homo sapiens	76-84
10479156-7	1999	In the presence of a nominal calcium buffer or EGTA, amphotericin B-induced IL-1beta expression is attenuated.	Egtazic Acid	47-51	interleukin 1 beta	Homo sapiens	76-84
10479156-7	1999	In the presence of a nominal calcium buffer or EGTA, amphotericin B-induced IL-1beta expression is attenuated.	Amphotericin B	53-67	interleukin 1 beta	Homo sapiens	76-84
10479156-8	1999	Thus, amphotericin B acts as an ionophore to increase [Ca++]i and activates calmodulin-mediated expression of IL-1beta in human monocytes.	Amphotericin B	6-20	interleukin 1 beta	Homo sapiens	110-118
10490998-5	1999	Here, we report that other inflammatory cytokines (IL-1 alpha, IL-1 beta, and IL-6) are also neuroprotective to excessive NMDA challenge in our system.	N-Methylaspartate	122-126	interleukin 1 beta	Homo sapiens	63-72
10547161-8	1999	Studies with cycloheximide, a protein synthesis inhibitor, demonstrated that de novo protein synthesis is required for IL-1beta induced MMP-9 expression.	Cycloheximide	13-26	interleukin 1 beta	Homo sapiens	119-127
10537260-13	1999	Rotation per se as well as exposure to increasing concentrations of PE and titanium particles stimulates cytokine release (TNF-alpha, IL-1beta, IL-8) by macrophages in vitro.	Titanium	75-83	interleukin 1 beta	Homo sapiens	134-142
10537260-9	1999	Using 40 X 10(8) PE particles (0.7 x 10(8) titanium particles) and 10(6) MLC, the maximal release of IL-1beta was about 20-fold (7-fold titanium particles) higher than that of the rotating control sample.	Titanium	43-51	interleukin 1 beta	Homo sapiens	101-109
10537260-9	1999	Using 40 X 10(8) PE particles (0.7 x 10(8) titanium particles) and 10(6) MLC, the maximal release of IL-1beta was about 20-fold (7-fold titanium particles) higher than that of the rotating control sample.	Titanium	136-144	interleukin 1 beta	Homo sapiens	101-109
10537260-13	1999	Rotation per se as well as exposure to increasing concentrations of PE and titanium particles stimulates cytokine release (TNF-alpha, IL-1beta, IL-8) by macrophages in vitro.	Polyethylene	68-70	interleukin 1 beta	Homo sapiens	134-142
10496962-4	1999	Resveratrol inhibits the transactivation of several dioxin-inducible genes including cytochrome P-450 1A1 and interleukin-1beta, both ex vivo and in vivo.	Resveratrol	0-11	interleukin 1 beta	Homo sapiens	110-127
10685373-7	1999	These results reveal that PGE2 at different concentrations exerts a biphasic effect on BMP-2-stimulated osteoblastic differentiation in HPLC, BMP-2 inhibits IL-1 beta-induced PGE2 production through suppressing COX-2 expression, and the BMP-2-stimulated osteoblastic differentiation may be enhanced by the endogenous PGE2 induced by BMP-2 and IL-1 beta.	Dinoprostone	26-30	interleukin 1 beta	Homo sapiens	157-166
10685373-7	1999	These results reveal that PGE2 at different concentrations exerts a biphasic effect on BMP-2-stimulated osteoblastic differentiation in HPLC, BMP-2 inhibits IL-1 beta-induced PGE2 production through suppressing COX-2 expression, and the BMP-2-stimulated osteoblastic differentiation may be enhanced by the endogenous PGE2 induced by BMP-2 and IL-1 beta.	Dinoprostone	26-30	interleukin 1 beta	Homo sapiens	343-352
10685373-7	1999	These results reveal that PGE2 at different concentrations exerts a biphasic effect on BMP-2-stimulated osteoblastic differentiation in HPLC, BMP-2 inhibits IL-1 beta-induced PGE2 production through suppressing COX-2 expression, and the BMP-2-stimulated osteoblastic differentiation may be enhanced by the endogenous PGE2 induced by BMP-2 and IL-1 beta.	Dinoprostone	175-179	interleukin 1 beta	Homo sapiens	157-166
10685373-7	1999	These results reveal that PGE2 at different concentrations exerts a biphasic effect on BMP-2-stimulated osteoblastic differentiation in HPLC, BMP-2 inhibits IL-1 beta-induced PGE2 production through suppressing COX-2 expression, and the BMP-2-stimulated osteoblastic differentiation may be enhanced by the endogenous PGE2 induced by BMP-2 and IL-1 beta.	Dinoprostone	175-179	interleukin 1 beta	Homo sapiens	157-166
10496962-4	1999	Resveratrol inhibits the transactivation of several dioxin-inducible genes including cytochrome P-450 1A1 and interleukin-1beta, both ex vivo and in vivo.	Dioxins	52-58	interleukin 1 beta	Homo sapiens	110-127
10496353-4	1999	MTT assay revealed that IL-1beta (10 ng ml(-1)) promoted cell growth in KU-19-19 and KU-19-20, while it inhibited in KU-1 and KU-2.	monooxyethylene trimethylolpropane tristearate	0-3	interleukin 1 beta	Homo sapiens	24-32
10500225-0	1999	IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels.	Calcium	34-41	interleukin 1 beta	Homo sapiens	0-8
10500225-4	1999	Confocal microscopy of astrocytes loaded with Indo-1 demonstrated that intercellular calcium wave transmission in IL-1beta-treated cultures was potentiated compared with controls.	Calcium	85-92	interleukin 1 beta	Homo sapiens	114-122
10500225-7	1999	Conversely, transmission of calcium waves via the P2 receptor-mediated pathway was potentiated in IL-1beta-treated cultures compared with controls.	Calcium	28-35	interleukin 1 beta	Homo sapiens	98-106
10477621-13	1999	The addition of mifepristone or caspase-3 inhibitor could partially abrogate GC-induced apoptosis as well as GC-induced inhibition of IL-1beta.	Mifepristone	16-28	interleukin 1 beta	Homo sapiens	134-142
10464291-2	1999	Mitogenic response of interleukin-1beta (IL-1beta) on VSMC is thought to be mediated by induction of endogenous platelet-derived growth factor (PDGF), especially PDGF-AA.	vsmc	54-58	interleukin 1 beta	Homo sapiens	22-39
10464291-2	1999	Mitogenic response of interleukin-1beta (IL-1beta) on VSMC is thought to be mediated by induction of endogenous platelet-derived growth factor (PDGF), especially PDGF-AA.	vsmc	54-58	interleukin 1 beta	Homo sapiens	41-49
10464291-7	1999	Both Western blotting and immunohistochemistry demonstrated that either C/EBPbeta or -delta expression was induced by IL-1beta exclusively in nuclei of VSMC.	vsmc	152-156	interleukin 1 beta	Homo sapiens	118-126
10460761-4	1999	Pretreatment of cultured epithelial cells with hemin (10 microM; 8 h) or interleukin (IL)-1beta (10 ng/ml; 16 h) completely inhibited increases in G and mannitol flux induced by H(2)O(2).	Mannitol	153-161	interleukin 1 beta	Homo sapiens	73-95
10460761-5	1999	Tin protoporphyrin IX (50 micrometer) and zinc protoporphyrin IX (10 microM), inhibitors of HO-1, reduced hemin-induced and IL-1beta-induced inhibitory effects.	tin protoporphyrin IX	0-21	interleukin 1 beta	Homo sapiens	124-132
10460761-5	1999	Tin protoporphyrin IX (50 micrometer) and zinc protoporphyrin IX (10 microM), inhibitors of HO-1, reduced hemin-induced and IL-1beta-induced inhibitory effects.	zinc protoporphyrin	42-64	interleukin 1 beta	Homo sapiens	124-132
10460194-3	1999	METHODS: The effect of haloperidol on the production of inflammatory cytokines interleukin 1beta (IL1beta) and tumour necrosis factor alpha (TNFalpha) was measured in bacterial lipopolysaccharide stimulated whole blood cultures and on the promonocyte cell line THP-1, using commercial and in house enzyme linked immunosorbent assays to measure cytokine concentrations.	Haloperidol	23-34	interleukin 1 beta	Homo sapiens	79-96
10460194-3	1999	METHODS: The effect of haloperidol on the production of inflammatory cytokines interleukin 1beta (IL1beta) and tumour necrosis factor alpha (TNFalpha) was measured in bacterial lipopolysaccharide stimulated whole blood cultures and on the promonocyte cell line THP-1, using commercial and in house enzyme linked immunosorbent assays to measure cytokine concentrations.	Haloperidol	23-34	interleukin 1 beta	Homo sapiens	98-105
10460194-4	1999	RESULTS: Haloperidol inhibited lipopolysaccharide stimulated production of both IL1beta and TNFalpha in vitro in a dose dependent manner and over a prolonged time period.	Haloperidol	9-20	interleukin 1 beta	Homo sapiens	80-87
10496353-5	1999	An ICE inhibitor, Acetyl-Tyr-Val-Ala-Asp-CHO (YVAD-CHO) blocked IL-1beta-induced growth inhibition in KU-1 and KU-2.	L 709049	18-44	interleukin 1 beta	Homo sapiens	64-72
10496353-5	1999	An ICE inhibitor, Acetyl-Tyr-Val-Ala-Asp-CHO (YVAD-CHO) blocked IL-1beta-induced growth inhibition in KU-1 and KU-2.	tyrosyl-valyl-alanyl-aspartal	46-54	interleukin 1 beta	Homo sapiens	64-72
10514258-6	1999	In our recent report, various immunoblotting analyses have shown that the presence of a core N-glycosylation resident in the hIL-1beta fragment is likely to be of crucial importance in the high-level secretion of hG-CSF from the recombinant S. cerevisiae.	Nitrogen	93-94	interleukin 1 beta	Homo sapiens	125-134
10469043-13	1999	These results suggest that Colo 201 cells adhere to IL-1beta-stimulated endothelial cells via SLea and E-selectin under low flow conditions; PGI2 analogues may protect against metastasis by inhibiting cancer cell-endothelial cell interactions.	Epoprostenol	141-145	interleukin 1 beta	Homo sapiens	52-60
10480601-3	1999	In particular, IL-1beta can impair glucose-stimulated insulin production in beta-cells in vitro and can sensitize them to Fas (CD95)/FasL-triggered apoptosis.	Glucose	35-42	interleukin 1 beta	Homo sapiens	15-23
10464058-7	1999	The IL-1beta-induced expression of C3 mRNA and C3 production were down-regulated by hyperthermia and sodium arsenite in a dose-dependent fashion.	sodium arsenite	101-116	interleukin 1 beta	Homo sapiens	4-12
10464058-8	1999	The results suggest that the stress response induced by hyperthermia or sodium arsenite decreases IL-1beta-induced C3 production in human enterocytes.	sodium arsenite	72-87	interleukin 1 beta	Homo sapiens	98-106
10480601-3	1999	In particular, IL-1beta can impair glucose-stimulated insulin production in beta-cells in vitro and can sensitize them to Fas (CD95)/FasL-triggered apoptosis.	ammonium ferrous sulfate	122-125	interleukin 1 beta	Homo sapiens	15-23
10480601-5	1999	We demonstrate that adenoviral gene delivery of the cDNA encoding the interleukin-1 receptor antagonist protein (IL-1Ra) to cultured islets results in protection of human islets in vitro against IL-1beta-induced nitric oxide formation, impairment in glucose-stimulated insulin production, and Fas-triggered apoptosis activation.	Nitric Oxide	212-224	interleukin 1 beta	Homo sapiens	195-203
10559642-6	1999	Following challenge with the combination of inflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma, such cultures exhibit a time-dependent increase in inducible NO synthetase induction and corresponding NO production, an effect which was inhibited by L-NMMA.	omega-N-Methylarginine	254-260	interleukin 1 beta	Homo sapiens	67-75
10490275-0	1999	Superoxide release from interleukin-1B-stimulated human vascular cells: in situ electrochemical measurement.	Superoxides	0-10	interleukin 1 beta	Homo sapiens	24-38
10490279-8	1999	Under these conditions, superoxide production was enhanced with agonists, including interleukin-1beta, A23187, and phorbol 12-myristate 13-acetate.	Superoxides	24-34	interleukin 1 beta	Homo sapiens	84-101
10482306-17	1999	Our results suggest that IL-1beta and TNF-alpha regulate osteoblast cell number by up-regulating the Fas-mediated apoptosis of osteoblasts, one of the putative mechanisms inducing periarticular osteoporosis in patients with RA.	ammonium ferrous sulfate	101-104	interleukin 1 beta	Homo sapiens	25-33
10467171-0	1999	Interleukin-1beta induces interleukin-6 production through the production of prostaglandin E(2) in human osteoblasts, MG-63 cells.	Dinoprostone	77-95	interleukin 1 beta	Homo sapiens	0-17
10467171-2	1999	Stimulation with IL-1beta resulted in the production of IL-6 and prostaglandin E(2) (PGE(2)).	Prostaglandins E	65-80	interleukin 1 beta	Homo sapiens	17-25
10467171-2	1999	Stimulation with IL-1beta resulted in the production of IL-6 and prostaglandin E(2) (PGE(2)).	Prostaglandins E	85-88	interleukin 1 beta	Homo sapiens	17-25
10467171-8	1999	In addition, stimulation with 17-phenyl-PGE(2), a PGE receptor-1 (EP-1 receptor) agonist, led to the expression of IL-6 mRNA after pretreatment with IL-1beta.	17-phenyl-pge	30-43	interleukin 1 beta	Homo sapiens	149-157
10467171-9	1999	These findings indicate that IL-1beta-induced IL-6 production in MG-63 cells involves the following sequence of steps: IL-1beta-induced COX-2 activation, PGE(2) production, and EP-1 receptor signaling prior to IL-6 production.	Prostaglandins E	154-157	interleukin 1 beta	Homo sapiens	29-37
10479405-9	1999	IL-6 did not influence the sensitivity towards CDDP of either wt or resistant cells, while IL-1alpha and IL-1beta enhanced sensitivity of resistant cells to CDDP.	Cisplatin	157-161	interleukin 1 beta	Homo sapiens	105-113
10453035-5	1999	IL-1 beta had no effect by itself, but potentiated the dexamethasone-induced increase in AGP production.	Dexamethasone	55-68	interleukin 1 beta	Homo sapiens	0-9
10453035-7	1999	Conditioned medium from LPS-stimulated macrophages as well as IL-1 beta had no effect by themselves, but potentiated the dexamethasone-induced increase in AGP mRNA levels.	Dexamethasone	121-134	interleukin 1 beta	Homo sapiens	62-71
10473679-9	1999	Incubation of titanium particulates (in concentrations similar to those found around loosened prosthetic joints) with cultured monocytes significantly increased their production of TNF-alpha, IL-1beta, and PGE(2).	Titanium	14-22	interleukin 1 beta	Homo sapiens	192-200
10489101-0	1999	The effect of erythropoietin on interleukin-1beta mediated increase in nitric oxide synthesis in vascular smooth muscle cells.	Nitric Oxide	71-83	interleukin 1 beta	Homo sapiens	32-49
10489101-1	1999	OBJECTIVE: Recently, we observed that recombinant human erythropoietin (rHuEPO) inhibits the interleukin (IL)-1beta induced nitric oxide (NO) production and inducible NO synthase (iNOS) expression in cultured rat vascular smooth muscle cells (VSMC).	Nitric Oxide	124-136	interleukin 1 beta	Homo sapiens	93-115
10489101-10	1999	rHuEPO inhibited not only IL-1beta induced nitrite production, but also the expression of iNOS mRNA and protein.	Nitrites	43-50	interleukin 1 beta	Homo sapiens	26-34
10489101-13	1999	The inhibitory effect of rHuEPO on IL-1beta induced nitrite production was also eliminated in PKC depleted cells or in the existence of anti-EpoR antibody.	Nitrites	52-59	interleukin 1 beta	Homo sapiens	35-43
10551904-10	1999	The effects of butyrate and Trichostatin-A were greater when cells were stimulated with IL-1beta.	Butyrates	15-23	interleukin 1 beta	Homo sapiens	88-96
10525446-1	1999	The human interleukin-1beta (IL-1beta) domain in position 163-171, comprising the amino acids VQGEESNDK, has been synthesized as a nine-amino-acid-long peptide and used in vivo as a nontoxic HCl salt.	hcl salt	191-199	interleukin 1 beta	Homo sapiens	10-27
10525446-1	1999	The human interleukin-1beta (IL-1beta) domain in position 163-171, comprising the amino acids VQGEESNDK, has been synthesized as a nine-amino-acid-long peptide and used in vivo as a nontoxic HCl salt.	hcl salt	191-199	interleukin 1 beta	Homo sapiens	29-37
10551904-10	1999	The effects of butyrate and Trichostatin-A were greater when cells were stimulated with IL-1beta.	trichostatin A	28-42	interleukin 1 beta	Homo sapiens	88-96
10499376-4	1999	The thromboxane mimetic U-46619 (10(-8)-10(-6) M) (9,11-dideoxy-11alpha,9alpha-epoxymethano-prostaglandin F2alpha)-induced contractions of human isolated small bronchi were not enhanced by interleukin-1beta pre-treatment, suggesting that no up-regulation of thromboxane receptors occurred.	Thromboxanes	4-15	interleukin 1 beta	Homo sapiens	189-206
10511209-9	1999	DEX caused dose-dependent inhibition of IL-1-induced IL-6 mRNA expression, while CSA potentiated IL-1-induced OF IL-6 mRNA expression.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	40-44
10667098-0	1999	In vitro effects of spiramycin and dirithromycin on IL1 beta production by human LPS-stimulated mononuclear cells.	Spiramycin	20-30	interleukin 1 beta	Homo sapiens	52-60
10667098-0	1999	In vitro effects of spiramycin and dirithromycin on IL1 beta production by human LPS-stimulated mononuclear cells.	dirithromycin	35-48	interleukin 1 beta	Homo sapiens	52-60
10667098-3	1999	This study reports the influence of macrolides, spiramycin and dirithromycin on IL1 beta production.	Macrolides	36-46	interleukin 1 beta	Homo sapiens	80-88
10667098-3	1999	This study reports the influence of macrolides, spiramycin and dirithromycin on IL1 beta production.	Spiramycin	48-58	interleukin 1 beta	Homo sapiens	80-88
10667098-3	1999	This study reports the influence of macrolides, spiramycin and dirithromycin on IL1 beta production.	dirithromycin	63-76	interleukin 1 beta	Homo sapiens	80-88
10667098-6	1999	At therapeutic concentrations, dirithromycin and spiramycin seemed to enhance IL1 beta production by LPS-stimulated cells, with +37 per cent and +28 per cent at 1 microgram/ml respectively.	dirithromycin	31-44	interleukin 1 beta	Homo sapiens	78-86
10667098-6	1999	At therapeutic concentrations, dirithromycin and spiramycin seemed to enhance IL1 beta production by LPS-stimulated cells, with +37 per cent and +28 per cent at 1 microgram/ml respectively.	Spiramycin	49-59	interleukin 1 beta	Homo sapiens	78-86
10667098-7	1999	At supratherapeutic concentrations, these drugs seemed to inhibit IL1 beta production through protein kinase C inhibition, with inhibitory concentrations 50 per cent of 378 micrograms/ml for dirithromycin and 234 micrograms/ml for spiramycin.	dirithromycin	191-204	interleukin 1 beta	Homo sapiens	66-74
10667098-7	1999	At supratherapeutic concentrations, these drugs seemed to inhibit IL1 beta production through protein kinase C inhibition, with inhibitory concentrations 50 per cent of 378 micrograms/ml for dirithromycin and 234 micrograms/ml for spiramycin.	Spiramycin	231-241	interleukin 1 beta	Homo sapiens	66-74
10499376-0	1999	Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi.	(o2)11	58-64	interleukin 1 beta	Homo sapiens	0-17
10499376-4	1999	The thromboxane mimetic U-46619 (10(-8)-10(-6) M) (9,11-dideoxy-11alpha,9alpha-epoxymethano-prostaglandin F2alpha)-induced contractions of human isolated small bronchi were not enhanced by interleukin-1beta pre-treatment, suggesting that no up-regulation of thromboxane receptors occurred.	9,11-dideoxy-11alpha	51-71	interleukin 1 beta	Homo sapiens	189-206
10499376-5	1999	Furthermore, the cyclooxygenase-2 inhibitor CGP 28238 (6-(2,4-difluorophenoxy)-5-methyl-sulfonylamino-1-indanon e) (10(-6) M) had no direct effect on [Sar9,Met(O2)11]substance P-provoked contractions, but inhibited the interleukin-1beta-induced potentiation of [Sar9,Met(O2)11]substance P response.	flosulide	44-53	interleukin 1 beta	Homo sapiens	219-236
10499376-6	1999	In conclusion, our results show that interleukin-1beta pre-treatment is able to potentiate the contractions of isolated human small bronchi provoked by [Sar9,Met(O2)11]substance P both by increasing prostanoid synthesis and by inducing a cyclooxygenase-2 pathway.	Prostaglandins	199-209	interleukin 1 beta	Homo sapiens	37-54
10457265-4	1999	Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect.	Dihydrotestosterone	15-41	interleukin 1 beta	Homo sapiens	102-110
10444519-0	1999	Effects of TNF-alpha and IL-1beta on iron metabolism by A549 cells and influence on cytotoxicity.	Iron	37-41	interleukin 1 beta	Homo sapiens	25-33
10444519-4	1999	The cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta may alter iron metabolism by alveolar cells.	Iron	85-89	interleukin 1 beta	Homo sapiens	52-74
10444519-5	1999	In this study, we assessed the effects of TNF-alpha and IL-1beta on iron metabolism with a cell line with properties of type 2 alveolar epithelial cells (A549) exposed to non-transferrin-bound (NTBI; FeSO(4)) or transferrin-bound (TBI) iron.	Iron	68-72	interleukin 1 beta	Homo sapiens	56-64
10444519-9	1999	TNF-alpha and IL-1beta decreased the uptake of TBI; however, the uptake of NTBI was increased.	Thioacetazone	47-50	interleukin 1 beta	Homo sapiens	14-22
10444519-12	1999	These findings indicate that TNF-alpha and IL-1beta modulate iron uptake by A549 cells, with differing effects on TBI and NTBI, as well as on H-ferritin synthesis.	Iron	61-65	interleukin 1 beta	Homo sapiens	43-51
10444519-12	1999	These findings indicate that TNF-alpha and IL-1beta modulate iron uptake by A549 cells, with differing effects on TBI and NTBI, as well as on H-ferritin synthesis.	Thioacetazone	114-117	interleukin 1 beta	Homo sapiens	43-51
10444519-12	1999	These findings indicate that TNF-alpha and IL-1beta modulate iron uptake by A549 cells, with differing effects on TBI and NTBI, as well as on H-ferritin synthesis.	ntbi	122-126	interleukin 1 beta	Homo sapiens	43-51
10455314-9	1999	In A549 cells treated for 24 h with interleukin-1beta, to induce COX-2, A771726 potently inhibited PGE2 synthesis (IC50 0.13 microg ml-1).	Dinoprostone	99-103	interleukin 1 beta	Homo sapiens	36-53
10482924-0	1999	Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes.	Adenosine Triphosphate	36-39	interleukin 1 beta	Homo sapiens	57-65
10482924-5	1999	ATP caused release of IL-1beta from LPS primed THP-1 cells in both a time- and concentration-dependent manner, with a minimal effective ATP concentration of 1 mM.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	22-30
10482924-5	1999	ATP caused release of IL-1beta from LPS primed THP-1 cells in both a time- and concentration-dependent manner, with a minimal effective ATP concentration of 1 mM.	Adenosine Triphosphate	136-139	interleukin 1 beta	Homo sapiens	22-30
10482924-6	1999	Stimulation of cells with 5 mM ATP resulted in detectable concentrations of IL-1beta in cell supernatants within 30 min.	Adenosine Triphosphate	31-34	interleukin 1 beta	Homo sapiens	76-84
10482924-8	1999	The ATP analogue benzoylbenzoyl ATP (DBATP), a P2X7 receptor agonist, was approximately 10 fold more potent than ATP at eliciting IL-1beta release.	Adenosine Triphosphate	4-7	interleukin 1 beta	Homo sapiens	130-138
10482924-8	1999	The ATP analogue benzoylbenzoyl ATP (DBATP), a P2X7 receptor agonist, was approximately 10 fold more potent than ATP at eliciting IL-1beta release.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	17-35	interleukin 1 beta	Homo sapiens	130-138
10482924-8	1999	The ATP analogue benzoylbenzoyl ATP (DBATP), a P2X7 receptor agonist, was approximately 10 fold more potent than ATP at eliciting IL-1beta release.	dbatp	37-42	interleukin 1 beta	Homo sapiens	130-138
10482924-8	1999	The ATP analogue benzoylbenzoyl ATP (DBATP), a P2X7 receptor agonist, was approximately 10 fold more potent than ATP at eliciting IL-1beta release.	Adenosine Triphosphate	32-35	interleukin 1 beta	Homo sapiens	130-138
10482924-10	1999	KN-62 (1 micro M), PPADS (100 microM) or oxidized ATP (100 uM) significantly inhibited 5 mM ATP-induced IL-1beta release by 81, 90 and 66% respectively, but failed to significantly inhibit LPS-induced IL-1beta release in both THP-1 cells and in freshly isolated human monocytes.	Adenosine Triphosphate	50-53	interleukin 1 beta	Homo sapiens	104-112
10482924-10	1999	KN-62 (1 micro M), PPADS (100 microM) or oxidized ATP (100 uM) significantly inhibited 5 mM ATP-induced IL-1beta release by 81, 90 and 66% respectively, but failed to significantly inhibit LPS-induced IL-1beta release in both THP-1 cells and in freshly isolated human monocytes.	Adenosine Triphosphate	50-53	interleukin 1 beta	Homo sapiens	201-209
10482924-10	1999	KN-62 (1 micro M), PPADS (100 microM) or oxidized ATP (100 uM) significantly inhibited 5 mM ATP-induced IL-1beta release by 81, 90 and 66% respectively, but failed to significantly inhibit LPS-induced IL-1beta release in both THP-1 cells and in freshly isolated human monocytes.	Adenosine Triphosphate	92-95	interleukin 1 beta	Homo sapiens	104-112
10482924-10	1999	KN-62 (1 micro M), PPADS (100 microM) or oxidized ATP (100 uM) significantly inhibited 5 mM ATP-induced IL-1beta release by 81, 90 and 66% respectively, but failed to significantly inhibit LPS-induced IL-1beta release in both THP-1 cells and in freshly isolated human monocytes.	Adenosine Triphosphate	92-95	interleukin 1 beta	Homo sapiens	201-209
10482924-15	1999	In conclusion our data confirm the involvement of P2X7 receptors in ATP-induced IL-1beta release in human monocytes.	Adenosine Triphosphate	68-71	interleukin 1 beta	Homo sapiens	80-88
10438953-9	1999	Although dexamethasone partially inhibited IL-1 beta- and TNF-alpha-induced up-regulation of ICAM-1 at 4 h, dexamethasone had no effect on cytokine-induced ICAM-1 expression at 18-24 h. In addition, neither cytokine-induced degradation or resynthesis of I kappa B alpha nor NF-kappa B DNA-binding activity were affected by dexamethasone.	Dexamethasone	9-22	interleukin 1 beta	Homo sapiens	43-52
10438960-3	1999	The effects of CTS are mediated by down-regulation of IL-1beta-dependent inducible NO production, and are directly attributed to the inhibition of inducible NO synthase (iNOS) mRNA expression and protein synthesis.	castanospermine	15-18	interleukin 1 beta	Homo sapiens	54-62
10438960-4	1999	The inhibition of iNOS induction by CTS is paralleled by abrogation of IL-1beta-induced down-regulation of proteoglycan synthesis.	castanospermine	36-39	interleukin 1 beta	Homo sapiens	71-79
10438960-5	1999	Furthermore, CTS inhibits iNOS expression and up-regulates proteoglycan synthesis at concentrations of IL-1beta frequently observed in inflamed arthritic joints, suggesting that the actions of CTS may be clinically relevant in suppressing the sustained effects of pathological levels of IL-1beta in vivo.	castanospermine	13-16	interleukin 1 beta	Homo sapiens	103-111
10438960-5	1999	Furthermore, CTS inhibits iNOS expression and up-regulates proteoglycan synthesis at concentrations of IL-1beta frequently observed in inflamed arthritic joints, suggesting that the actions of CTS may be clinically relevant in suppressing the sustained effects of pathological levels of IL-1beta in vivo.	castanospermine	13-16	interleukin 1 beta	Homo sapiens	287-295
10457265-4	1999	Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect.	Dihydrotestosterone	15-41	interleukin 1 beta	Homo sapiens	244-252
10430608-3	1999	TLR4 expression levels in cardiac myocytes and in coronary microvascular endothelial cells could be enhanced by either LPS or IL-1beta, an effect inhibited by the oxygen radical scavenger PDTC.	Oxygen	163-169	interleukin 1 beta	Homo sapiens	126-134
10457265-4	1999	Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect.	Dihydrotestosterone	43-46	interleukin 1 beta	Homo sapiens	102-110
10457265-4	1999	Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect.	Dihydrotestosterone	43-46	interleukin 1 beta	Homo sapiens	244-252
10457265-4	1999	Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect.	hfob	155-159	interleukin 1 beta	Homo sapiens	102-110
10457265-4	1999	Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect.	hfob	155-159	interleukin 1 beta	Homo sapiens	244-252
10457265-4	1999	Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect.	Testosterone	29-41	interleukin 1 beta	Homo sapiens	102-110
10457265-4	1999	Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect.	Testosterone	29-41	interleukin 1 beta	Homo sapiens	244-252
10391852-6	1999	In addition, proinflammatory cytokine (interleukin 1beta [IL-1beta] and tumor necrosis factor alpha [TNF-alpha]) levels are greater in culture wells containing discs of polyolefin polymer than in those containing discs of polyvinyl chloride polymer with the TEHTM plasticizer, and even more so in storage bags containing polyolefin polymer versus polyvinyl chloride polymer with the TEHTM plasticizer (IL-1beta, TNF-alpha, IL-6, and IL-8).	polyolefin polymer	169-187	interleukin 1 beta	Homo sapiens	39-56
10517185-5	1999	Of particular note was the ability of IL-1beta to promote the secretion of a form of lumican deficient in keratan sulfate/polylactosamine chains, whereas with bFGF, IGF-1 and TGFbeta keratan sulfate/polylactosamine chains were present, though their size or degree of substitution varied.	Keratan Sulfate	106-121	interleukin 1 beta	Homo sapiens	38-46
10517185-5	1999	Of particular note was the ability of IL-1beta to promote the secretion of a form of lumican deficient in keratan sulfate/polylactosamine chains, whereas with bFGF, IGF-1 and TGFbeta keratan sulfate/polylactosamine chains were present, though their size or degree of substitution varied.	polylactosamine	122-137	interleukin 1 beta	Homo sapiens	38-46
10517185-5	1999	Of particular note was the ability of IL-1beta to promote the secretion of a form of lumican deficient in keratan sulfate/polylactosamine chains, whereas with bFGF, IGF-1 and TGFbeta keratan sulfate/polylactosamine chains were present, though their size or degree of substitution varied.	polylactosamine	199-214	interleukin 1 beta	Homo sapiens	38-46
10437800-5	1999	In lipopolysaccharide-stimulated cells, sulfatide but not gal-cer decreased the secretion of IL-1beta and IL-10, a potent suppressor of production of many cytokines.	Sulfoglycosphingolipids	40-49	interleukin 1 beta	Homo sapiens	93-101
10395693-8	1999	Interestingly, in the presence of LPS or exogenous IL-1 beta, COX-2 transcripts were stabilized, and actinomycin D inhibited their degradation.	Dactinomycin	101-114	interleukin 1 beta	Homo sapiens	51-60
10395693-9	1999	Only when LPS or IL-1 beta was removed did COX-2 mRNA decay with a t1/2 of &gt;/=5 h. In contrast, dexamethasone promoted a faster decay of the LPS-induced COX-2 transcripts (t1/2 = 2.5 h).	Dexamethasone	99-112	interleukin 1 beta	Homo sapiens	17-26
10393680-8	1999	In explants, indomethacin 10 micromol/L or mefenamic acid 10 micromol/L abolished PGE2 secretion and significantly reduced IL-1beta and IL-6 secretion.	Indomethacin	13-25	interleukin 1 beta	Homo sapiens	123-131
10393680-8	1999	In explants, indomethacin 10 micromol/L or mefenamic acid 10 micromol/L abolished PGE2 secretion and significantly reduced IL-1beta and IL-6 secretion.	Mefenamic Acid	43-57	interleukin 1 beta	Homo sapiens	123-131
10408390-10	1999	Pretreatment of HT29 cells with dactinomycin abrogated the induction of VEGF mRNA by IL-1beta.	Dactinomycin	32-44	interleukin 1 beta	Homo sapiens	85-93
10391852-6	1999	In addition, proinflammatory cytokine (interleukin 1beta [IL-1beta] and tumor necrosis factor alpha [TNF-alpha]) levels are greater in culture wells containing discs of polyolefin polymer than in those containing discs of polyvinyl chloride polymer with the TEHTM plasticizer, and even more so in storage bags containing polyolefin polymer versus polyvinyl chloride polymer with the TEHTM plasticizer (IL-1beta, TNF-alpha, IL-6, and IL-8).	polyvinyl chloride polymer	347-373	interleukin 1 beta	Homo sapiens	39-56
10437800-2	1999	In human mononuclear leucocytes, gal-cer but not sulfatide induced significantly increased amounts of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF) mRNA.	Galactosylceramides	33-40	interleukin 1 beta	Homo sapiens	102-124
10391911-7	1999	Moreover, both tumor necrosis factor-alpha and interleukin-1beta, cytokines that mediate many of the metabolic effects of LPS, increased hepatic GlcCer synthase mRNA levels in vivo as well as in HepG2 cells in vitro, suggesting that these cytokines can directly stimulate glycosphingolipid metabolism.	Glycosphingolipids	272-289	interleukin 1 beta	Homo sapiens	47-64
10383598-8	1999	Pretreatment with dexamethasone abolished IL-1beta- and BK-stimulated COX-2 induction in all cells studied.	Dexamethasone	18-31	interleukin 1 beta	Homo sapiens	42-50
10383598-10	1999	Both IL-1beta and BK induced COX-2 expression in all cells studied and this induction was blocked by dexamethasone.	Dexamethasone	101-114	interleukin 1 beta	Homo sapiens	5-13
10391852-6	1999	In addition, proinflammatory cytokine (interleukin 1beta [IL-1beta] and tumor necrosis factor alpha [TNF-alpha]) levels are greater in culture wells containing discs of polyolefin polymer than in those containing discs of polyvinyl chloride polymer with the TEHTM plasticizer, and even more so in storage bags containing polyolefin polymer versus polyvinyl chloride polymer with the TEHTM plasticizer (IL-1beta, TNF-alpha, IL-6, and IL-8).	polyolefin polymer	169-187	interleukin 1 beta	Homo sapiens	58-66
10391852-6	1999	In addition, proinflammatory cytokine (interleukin 1beta [IL-1beta] and tumor necrosis factor alpha [TNF-alpha]) levels are greater in culture wells containing discs of polyolefin polymer than in those containing discs of polyvinyl chloride polymer with the TEHTM plasticizer, and even more so in storage bags containing polyolefin polymer versus polyvinyl chloride polymer with the TEHTM plasticizer (IL-1beta, TNF-alpha, IL-6, and IL-8).	polyolefin polymer	169-187	interleukin 1 beta	Homo sapiens	402-410
10391852-6	1999	In addition, proinflammatory cytokine (interleukin 1beta [IL-1beta] and tumor necrosis factor alpha [TNF-alpha]) levels are greater in culture wells containing discs of polyolefin polymer than in those containing discs of polyvinyl chloride polymer with the TEHTM plasticizer, and even more so in storage bags containing polyolefin polymer versus polyvinyl chloride polymer with the TEHTM plasticizer (IL-1beta, TNF-alpha, IL-6, and IL-8).	polyolefin polymer	321-339	interleukin 1 beta	Homo sapiens	39-56
10568060-4	1999	Application of diclofenac after abdominal hysterectomies reduced substantially intraperitoneal IL-1 beta levels.	Diclofenac	15-25	interleukin 1 beta	Homo sapiens	95-104
10388637-9	1999	Indomethacin also reduced the release of interleukin-1beta (IL-1beta) (from 166 pg/ml to 9.8 pg/ml, p =0.04, n=5) and interleukin-6 (IL-6) (from 119 ng/ml to 57 ng/ml, p=0.028, n=6), but had no effect on monocyte chemotactic protein 1 or matrix metalloproteinase-9 secretion.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	60-68
10446825-4	1999	We hypothesized the following: a) TNF-alpha and IL-1beta directly depress human myocardial function; b) together, TNF-alpha and IL-1beta act synergistically to depress human myocardial function; and c) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1beta by limiting proximal cytokine signaling or production of myocardial nitric oxide (NO).	Nitric Oxide	230-242	interleukin 1 beta	Homo sapiens	48-56
10446825-4	1999	We hypothesized the following: a) TNF-alpha and IL-1beta directly depress human myocardial function; b) together, TNF-alpha and IL-1beta act synergistically to depress human myocardial function; and c) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1beta by limiting proximal cytokine signaling or production of myocardial nitric oxide (NO).	Nitric Oxide	230-242	interleukin 1 beta	Homo sapiens	128-136
10446825-4	1999	We hypothesized the following: a) TNF-alpha and IL-1beta directly depress human myocardial function; b) together, TNF-alpha and IL-1beta act synergistically to depress human myocardial function; and c) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1beta by limiting proximal cytokine signaling or production of myocardial nitric oxide (NO).	Nitric Oxide	230-242	interleukin 1 beta	Homo sapiens	128-136
10446825-13	1999	Inhibition of myocardial sphingosine or NO release abolished the myocardial depressive effects of either TNF-alpha or IL-1beta.	Sphingosine	25-36	interleukin 1 beta	Homo sapiens	118-126
10446825-15	1999	Sphingosine likely participates in the TNF-alpha and IL-1beta signal leading to human myocardial functional depression.	Sphingosine	0-11	interleukin 1 beta	Homo sapiens	53-61
10414449-5	1999	Our results have shown that ATRA induces an increased expression of IL-8, IL-1beta, TNF-alpha and ICAM-1 in APL cells, which can be amplified by the addition of G-CSF.	Tretinoin	28-32	interleukin 1 beta	Homo sapiens	74-82
10381916-7	1999	In contrast, IL-1beta-induced NF-kappaB activation was associated with the disappearance of IkappaBalpha and was inhibited by ALLN but not staurosporine.	Staurosporine	139-152	interleukin 1 beta	Homo sapiens	13-21
10388637-11	1999	Indomethacin reduces the production of PGE2, IL-1beta and IL-6, suggesting that cyclo-oxygenase-2 inhibitors may control the inflammation in the aneurysm wall and potentially limit AAA growth.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	45-53
10405202-3	1999	Stimulation with lipopolysaccharide and IL-1beta resulted in the full induction of IL-6 expression only if the cells were coincubated with cAMP agonists; this effect was attenuated by protein kinase A inhibitors.	Cyclic AMP	139-143	interleukin 1 beta	Homo sapiens	40-48
10406833-9	1999	In contrast, in monocytes preincubated with losartan before exposure to Ang II, IL-1beta secretion was diminished in both groups to comparable levels.	Losartan	44-52	interleukin 1 beta	Homo sapiens	80-88
10419775-1	1999	Objective Since articular chondrocytes and synovial fibroblasts are particularly responsive to interleukin-1 (IL-1) with respect to stimulation of prostaglandin E(2)(PGE(2)) biosynthesis, we have used them as models to examine feedback modulatory effects of PGE(2), which blocks or attenuates the direct effects of IL-1beta on cell-specific collagen gene expression.	Prostaglandins E	166-169	interleukin 1 beta	Homo sapiens	315-323
10440637-12	1999	RESULTS: Estradiol at concentrations of 0.04 ng/ml or more significantly reduced both IL-1alpha and IL- 1beta production.	Estradiol	9-18	interleukin 1 beta	Homo sapiens	100-109
10353264-0	1999	Up-regulation of interleukin-1beta-stimulated interleukin-8 in human keratinocytes by nitric oxide.	Nitric Oxide	86-98	interleukin 1 beta	Homo sapiens	17-34
10463464-3	1999	When the cells were incubated with either IL-1beta (100 ng/l) or TNF-alpha (10 microg/l) for 4 h prior to exposure to paracetamol, the permeability of the bilayer to the drug increased to that of the control inserts without cells.	Acetaminophen	118-129	interleukin 1 beta	Homo sapiens	42-50
10377395-14	1999	The enzyme activity is glutathione-dependent, and the protein expression is induced by the proinflammatory cytokine IL-1beta.	Glutathione	23-34	interleukin 1 beta	Homo sapiens	116-124
10385089-7	1999	This reduction occurred despite equivalent serum levels of lipopolysaccharide, consistent with the reductions in TNF-alpha and interleukin-1beta production by host macrophages after cyclophosphamide pretreatment.	Cyclophosphamide	182-198	interleukin 1 beta	Homo sapiens	127-144
29539851-11	1999	Following treatment, a reduction in IL-1beta concentration in GCF was seen for PAG(-) but not for PAG(+) patients.	pag	79-82	interleukin 1 beta	Homo sapiens	36-44
10401557-8	1999	Moreover, rolipram significantly potentiated hyperalgesia induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, IL-6 and IL-8.	Rolipram	10-18	interleukin 1 beta	Homo sapiens	105-114
10401557-15	1999	The ODQ potentiated hyperalgesia induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, IL-6 and IL-8.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	4-7	interleukin 1 beta	Homo sapiens	80-89
10580548-5	1999	Inhibition of [methyl-3H]thymidine incorporation by IL-1beta was lower than that observed with HUVEC, while TNF-alpha reduced the proliferation of IVEC and HUVEC to similar extents.	methyl-3h	15-24	interleukin 1 beta	Homo sapiens	52-60
10580548-5	1999	Inhibition of [methyl-3H]thymidine incorporation by IL-1beta was lower than that observed with HUVEC, while TNF-alpha reduced the proliferation of IVEC and HUVEC to similar extents.	Thymidine	25-34	interleukin 1 beta	Homo sapiens	52-60
10580548-8	1999	Dexamethasone treatment of IVEC restored their reactivity to IL-1beta and corrected the IL-1beta binding and the receptor number.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	61-69
10580548-8	1999	Dexamethasone treatment of IVEC restored their reactivity to IL-1beta and corrected the IL-1beta binding and the receptor number.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	88-96
10342828-5	1999	However, cotreatment of the cells with 17beta-E2 and increasing concentrations of either tumor necrosis factor-alpha (TNF alpha), interleukin-1alpha (IL-1alpha), or IL-1beta completely suppressed ERE-tk-luciferase activity in a dose-dependent manner (IC50 = 0.05-5.0 pM).	17beta-e2	39-48	interleukin 1 beta	Homo sapiens	165-173
10411659-0	1999	The effect of interleukin 1 beta on the biosynthesis of cholesterol, phosphatidylcholine, and sphingomyelin in fibroblasts, and on their efflux from cells to lipid-free apolipoprotein A-I.	Cholesterol	56-67	interleukin 1 beta	Homo sapiens	14-32
10411659-0	1999	The effect of interleukin 1 beta on the biosynthesis of cholesterol, phosphatidylcholine, and sphingomyelin in fibroblasts, and on their efflux from cells to lipid-free apolipoprotein A-I.	Sphingomyelins	94-107	interleukin 1 beta	Homo sapiens	14-32
10411659-1	1999	In this study we have investigated the effect of interleukin 1beta (IL-1beta) on the metabolism of cholesterol and choline-phospholipids in cultured fibroblasts, and also measured efflux of these lipids to lipid-free apo A-I as a function of IL-1beta treatment.	Cholesterol	99-110	interleukin 1 beta	Homo sapiens	49-66
10411659-1	1999	In this study we have investigated the effect of interleukin 1beta (IL-1beta) on the metabolism of cholesterol and choline-phospholipids in cultured fibroblasts, and also measured efflux of these lipids to lipid-free apo A-I as a function of IL-1beta treatment.	Cholesterol	99-110	interleukin 1 beta	Homo sapiens	68-76
10411659-1	1999	In this study we have investigated the effect of interleukin 1beta (IL-1beta) on the metabolism of cholesterol and choline-phospholipids in cultured fibroblasts, and also measured efflux of these lipids to lipid-free apo A-I as a function of IL-1beta treatment.	Choline	115-122	interleukin 1 beta	Homo sapiens	49-66
10411659-1	1999	In this study we have investigated the effect of interleukin 1beta (IL-1beta) on the metabolism of cholesterol and choline-phospholipids in cultured fibroblasts, and also measured efflux of these lipids to lipid-free apo A-I as a function of IL-1beta treatment.	Choline	115-122	interleukin 1 beta	Homo sapiens	68-76
10380911-3	1999	Aspirin had minor effects on ex vivo secretion of IL-1beta and no influence on IL-1ra.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	50-58
10397510-10	1999	In shallow sites (&lt;4 mm), total IL-1beta in GCF was 2.5 times higher for PAG(+) patients prior to treatment (P=0.03), and 2.2 times higher after treatment (P=0.04), while differences were less apparent in deeper sites.	pag	76-79	interleukin 1 beta	Homo sapiens	35-43
10397510-11	1999	Following treatment, a reduction in IL-1beta concentration in GCF was seen for PAG(-) but not for PAG(+) patients.	pag	79-82	interleukin 1 beta	Homo sapiens	36-44
10397510-11	1999	Following treatment, a reduction in IL-1beta concentration in GCF was seen for PAG(-) but not for PAG(+) patients.	pag	98-101	interleukin 1 beta	Homo sapiens	36-44
10397510-12	1999	While not statistically significant, a trend was observed in mean tissue levels of IL-1beta which were 3.6 times higher in PAG(+) versus PAG(-) patients (P=0.09).	pag	123-126	interleukin 1 beta	Homo sapiens	83-91
10397510-12	1999	While not statistically significant, a trend was observed in mean tissue levels of IL-1beta which were 3.6 times higher in PAG(+) versus PAG(-) patients (P=0.09).	pag	137-140	interleukin 1 beta	Homo sapiens	83-91
10397510-13	1999	CONCLUSIONS: These data suggest that PAG(+) patients may demonstrate phenotypic differences as indicated by elevated levels of IL-1beta in GCF.	pag	37-40	interleukin 1 beta	Homo sapiens	127-135
10403637-5	1999	A 24 h exposure to ethanol induced the expression of TNF-alpha and TGF-beta1, and the secretion of IL-1beta and TGF-beta1.	Ethanol	19-26	interleukin 1 beta	Homo sapiens	99-107
10403637-6	1999	With the same period of treatment, acetaldehyde markedly increased TNF-alpha expression, and stimulated IL-1beta secretion, while LPS exposure induced the expression of TNF-alpha, IL-6, and TGF-beta1, and the secretion of IL-1beta, IL-6, and TGF-beta1.	Acetaldehyde	35-47	interleukin 1 beta	Homo sapiens	104-112
10389698-7	1999	Crohn"s disease patients had a markedly decreased dexamethasone-mediated inhibition of TNF-alpha (P &lt; 0.01), IL-6 (P &lt; 0.001), and IL-1 beta (P &lt; 0.01) compared to healthy subjects, with a shift of the dexamethasone dose-response curve to the right.	Dexamethasone	50-63	interleukin 1 beta	Homo sapiens	137-146
10411659-1	1999	In this study we have investigated the effect of interleukin 1beta (IL-1beta) on the metabolism of cholesterol and choline-phospholipids in cultured fibroblasts, and also measured efflux of these lipids to lipid-free apo A-I as a function of IL-1beta treatment.	Phospholipids	123-136	interleukin 1 beta	Homo sapiens	49-66
10411659-1	1999	In this study we have investigated the effect of interleukin 1beta (IL-1beta) on the metabolism of cholesterol and choline-phospholipids in cultured fibroblasts, and also measured efflux of these lipids to lipid-free apo A-I as a function of IL-1beta treatment.	Phospholipids	123-136	interleukin 1 beta	Homo sapiens	68-76
10411659-2	1999	Long-term exposure (up to 48 h) of cells to IL-1beta (1 ng.mL-1) markedly increased the rate of cholesterol esterification, as determined by the incorporation of [3H]oleic acid into cholesteryl esters.	Cholesterol	96-107	interleukin 1 beta	Homo sapiens	44-52
10411659-2	1999	Long-term exposure (up to 48 h) of cells to IL-1beta (1 ng.mL-1) markedly increased the rate of cholesterol esterification, as determined by the incorporation of [3H]oleic acid into cholesteryl esters.	[3h]oleic acid	162-176	interleukin 1 beta	Homo sapiens	44-52
10411659-2	1999	Long-term exposure (up to 48 h) of cells to IL-1beta (1 ng.mL-1) markedly increased the rate of cholesterol esterification, as determined by the incorporation of [3H]oleic acid into cholesteryl esters.	Cholesterol Esters	182-200	interleukin 1 beta	Homo sapiens	44-52
10411659-4	1999	The accumulation of cholesteryl esters in IL-1beta-treated cells could be blocked using compound 58-035 to inhibit the activity of acyl-CoA cholesterol acyl transferase.	Cholesterol Esters	20-38	interleukin 1 beta	Homo sapiens	42-50
10411659-5	1999	The activation of cholesterol esterification by IL-1beta was evident within a few hours after initiation of the IL-1beta treatment.	Cholesterol	18-29	interleukin 1 beta	Homo sapiens	48-56
10411659-5	1999	The activation of cholesterol esterification by IL-1beta was evident within a few hours after initiation of the IL-1beta treatment.	Cholesterol	18-29	interleukin 1 beta	Homo sapiens	112-120
10411659-6	1999	Cholesterol biosynthesis was inhibited by 25% by IL-1beta (after 48 h exposure), and this eventually led to a 20% decrease in cell cholesterol mass.	Cholesterol	0-11	interleukin 1 beta	Homo sapiens	49-57
10411659-6	1999	Cholesterol biosynthesis was inhibited by 25% by IL-1beta (after 48 h exposure), and this eventually led to a 20% decrease in cell cholesterol mass.	Cholesterol	131-142	interleukin 1 beta	Homo sapiens	49-57
10411659-7	1999	Treatment of cells with IL-1beta for 48 h also reduced the synthesis of sphingomyelin and caused a 30% decrease in cell sphingomyelin mass (after 48 h at 1 ng.mL-1 of IL-1beta).	Sphingomyelins	72-85	interleukin 1 beta	Homo sapiens	24-32
10411659-7	1999	Treatment of cells with IL-1beta for 48 h also reduced the synthesis of sphingomyelin and caused a 30% decrease in cell sphingomyelin mass (after 48 h at 1 ng.mL-1 of IL-1beta).	Sphingomyelins	120-133	interleukin 1 beta	Homo sapiens	24-32
10411659-7	1999	Treatment of cells with IL-1beta for 48 h also reduced the synthesis of sphingomyelin and caused a 30% decrease in cell sphingomyelin mass (after 48 h at 1 ng.mL-1 of IL-1beta).	Sphingomyelins	120-133	interleukin 1 beta	Homo sapiens	167-175
10411659-10	1999	The rate of phosphatidylcholine synthesis was barely affected, but mass was moderately reduced by a 48-h treatment of cells with IL-1beta.	Phosphatidylcholines	12-31	interleukin 1 beta	Homo sapiens	129-137
10411659-11	1999	Finally, the efflux of cell [3H]cholesterol, [3H]sphingomyelin, and [3H]phosphatidylcholine to lipid-free apolipoprotein A-I was markedly increased from cells treated with IL-1beta for 24 and 48 h. We conclude that long-term exposure of cells to IL-1beta had marked effects on the cellular homeostasis of cholesterol and choline-containing phospholipids.	Phosphatidylcholines	72-91	interleukin 1 beta	Homo sapiens	172-180
10411659-11	1999	Finally, the efflux of cell [3H]cholesterol, [3H]sphingomyelin, and [3H]phosphatidylcholine to lipid-free apolipoprotein A-I was markedly increased from cells treated with IL-1beta for 24 and 48 h. We conclude that long-term exposure of cells to IL-1beta had marked effects on the cellular homeostasis of cholesterol and choline-containing phospholipids.	Cholesterol	305-316	interleukin 1 beta	Homo sapiens	172-180
10411659-11	1999	Finally, the efflux of cell [3H]cholesterol, [3H]sphingomyelin, and [3H]phosphatidylcholine to lipid-free apolipoprotein A-I was markedly increased from cells treated with IL-1beta for 24 and 48 h. We conclude that long-term exposure of cells to IL-1beta had marked effects on the cellular homeostasis of cholesterol and choline-containing phospholipids.	Phospholipids	340-353	interleukin 1 beta	Homo sapiens	172-180
10447739-3	1999	An antibody to IL-1beta was without effect after 4 hr of culture, inhibited endotoxin-stimulated prostaglandin E2 (PGE2) production after 8 hr of culture, and caused a parallel decrease in the expression of mRNA for COX-2.	Dinoprostone	97-113	interleukin 1 beta	Homo sapiens	15-23
10447739-3	1999	An antibody to IL-1beta was without effect after 4 hr of culture, inhibited endotoxin-stimulated prostaglandin E2 (PGE2) production after 8 hr of culture, and caused a parallel decrease in the expression of mRNA for COX-2.	Dinoprostone	115-119	interleukin 1 beta	Homo sapiens	15-23
10447739-7	1999	We conclude that CRH and PAF can induce the expression of IL-1beta, but this is not obligatory for increased PGE2 release, and the effect of these stimuli on COX-2 expression is a direct, IL-1beta-independent effect.	Platelet Activating Factor	25-28	interleukin 1 beta	Homo sapiens	58-66
10447739-7	1999	We conclude that CRH and PAF can induce the expression of IL-1beta, but this is not obligatory for increased PGE2 release, and the effect of these stimuli on COX-2 expression is a direct, IL-1beta-independent effect.	Platelet Activating Factor	25-28	interleukin 1 beta	Homo sapiens	188-196
29539851-11	1999	Following treatment, a reduction in IL-1beta concentration in GCF was seen for PAG(-) but not for PAG(+) patients.	pag	98-101	interleukin 1 beta	Homo sapiens	36-44
29539851-12	1999	While not statistically significant, a trend was observed in mean tissue levels of IL-1beta which were 3.6 times higher in PAG(+) versus PAG(-) patients (P = 0.09).	pag	123-126	interleukin 1 beta	Homo sapiens	83-91
29539851-12	1999	While not statistically significant, a trend was observed in mean tissue levels of IL-1beta which were 3.6 times higher in PAG(+) versus PAG(-) patients (P = 0.09).	pag	137-140	interleukin 1 beta	Homo sapiens	83-91
10442856-8	1999	Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells.	Ethanol	55-62	interleukin 1 beta	Homo sapiens	199-207
10442856-5	1999	In another set of experiments to study ethanol effects, DLD-1 monolayers were pretreated with 66 mM ethanol for 24 h. These cells showed significant upregulation of IL-1beta mRNA and protein as detected in the supernatants.	Ethanol	39-46	interleukin 1 beta	Homo sapiens	165-173
10442856-5	1999	In another set of experiments to study ethanol effects, DLD-1 monolayers were pretreated with 66 mM ethanol for 24 h. These cells showed significant upregulation of IL-1beta mRNA and protein as detected in the supernatants.	Ethanol	100-107	interleukin 1 beta	Homo sapiens	165-173
10442856-8	1999	Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells.	Ethanol	25-32	interleukin 1 beta	Homo sapiens	84-92
10350557-2	1999	Co-injection of the selective glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA) with human recombinant IL-1beta (hrIL-1beta) in the striatum of rats results in both local (striatal) damage and extensive, distant neuronal death in the cortex.	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate	57-109	interleukin 1 beta	Homo sapiens	142-150
10350557-2	1999	Co-injection of the selective glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA) with human recombinant IL-1beta (hrIL-1beta) in the striatum of rats results in both local (striatal) damage and extensive, distant neuronal death in the cortex.	hril	152-156	interleukin 1 beta	Homo sapiens	142-150
10395413-4	1999	Both maximal contraction and potency to sarafotoxin S6c were increased in segments incubated with IL-1beta .	sarafotoxin	40-51	interleukin 1 beta	Homo sapiens	98-106
10442856-8	1999	Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells.	Ethanol	55-62	interleukin 1 beta	Homo sapiens	84-92
10442856-8	1999	Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells.	Ethanol	25-32	interleukin 1 beta	Homo sapiens	199-207
10442856-8	1999	Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells.	Ethanol	55-62	interleukin 1 beta	Homo sapiens	84-92
10442856-8	1999	Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells.	Ethanol	55-62	interleukin 1 beta	Homo sapiens	199-207
10442856-9	1999	Because IFN-gamma and IL-1beta are produced by intestinal immune cells, these findings may have implications for differential in vivo regulation of epithelial iNOS genes by ethanol, depending on the inflammatory and immune status of the host.	Ethanol	173-180	interleukin 1 beta	Homo sapiens	22-30
10203417-12	1999	Interestingly, IL-1 treatment increased the expression of collagenase mRNA by sevenfold, compared with that of the Dex group.	Dexamethasone	115-118	interleukin 1 beta	Homo sapiens	15-19
10226077-9	1999	In combination with competitive cotransfection studies using consensus oligonucleotides mimicking these motifs, we conclude that transactivation of an NF-kappaB-like sequence is necessary for induction of the IL-1beta gene, that activation of CRE may repress induction of the gene, and that AP-1 potentially modulates induction and repression of the gene induced by fibrinogen.	Oligonucleotides	71-87	interleukin 1 beta	Homo sapiens	209-217
10203417-5	1999	In contrast, the cells treated with IL-1, Dex, GP, and AA (IL-1 group) did form multilayers but failed to form mineralized nodules.	Dexamethasone	42-45	interleukin 1 beta	Homo sapiens	59-63
10399582-0	1999	[Effects of interleukin-1beta and indomethacin on interleukin-1beta gene expression in the brain hemispheres].	Indomethacin	34-46	interleukin 1 beta	Homo sapiens	50-67
10369458-1	1999	Ceramide, generated by the hydrolysis of sphingomyelin, mediates the actions of several cytokines such as tumour necrosis factor-alpha (TNF-alpha) interferon-gamma and interleukin-1beta (IL-1beta), including their inhibitory effect on tumour proliferation.	Ceramides	0-8	interleukin 1 beta	Homo sapiens	168-185
10361345-5	1999	Indomethacin diminished secretion of PGE2, IL-1beta and IL-6 by AAA explants (see Table below).	Indomethacin	1-13	interleukin 1 beta	Homo sapiens	44-52
10361345-8	1999	Indomethacin reduces PGE2, IL-1beta and IL-6 synthesis in aneurysm tissue and NSAIDs appear to reduce AAA growth.	Indomethacin	1-13	interleukin 1 beta	Homo sapiens	28-36
10203417-9	1999	Northern blot analysis of IL-1-treated cells, however, revealed the presence of mRNAs for type I collagen (Col I), secreted protein, acidic and rich in cysteine (SPARC), osteopontin (OPN), alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteocalcin (OC), whose expression patterns and levels were comparable to those of the Dex group.	Dexamethasone	333-336	interleukin 1 beta	Homo sapiens	26-30
10369458-1	1999	Ceramide, generated by the hydrolysis of sphingomyelin, mediates the actions of several cytokines such as tumour necrosis factor-alpha (TNF-alpha) interferon-gamma and interleukin-1beta (IL-1beta), including their inhibitory effect on tumour proliferation.	Ceramides	0-8	interleukin 1 beta	Homo sapiens	187-195
10369458-1	1999	Ceramide, generated by the hydrolysis of sphingomyelin, mediates the actions of several cytokines such as tumour necrosis factor-alpha (TNF-alpha) interferon-gamma and interleukin-1beta (IL-1beta), including their inhibitory effect on tumour proliferation.	Sphingomyelins	41-54	interleukin 1 beta	Homo sapiens	168-185
10369458-1	1999	Ceramide, generated by the hydrolysis of sphingomyelin, mediates the actions of several cytokines such as tumour necrosis factor-alpha (TNF-alpha) interferon-gamma and interleukin-1beta (IL-1beta), including their inhibitory effect on tumour proliferation.	Sphingomyelins	41-54	interleukin 1 beta	Homo sapiens	187-195
10369458-6	1999	IL-1beta produced profound inhibition of LNCaP cell proliferation and caused enhanced ceramide formation.	Ceramides	86-94	interleukin 1 beta	Homo sapiens	0-8
10328874-3	1999	We found that two members of the NSAIDs, sodium salicylate and sulindac repress the IL1B promoter to similar degree to heat shock or HSF1 overexpression.	Sodium Salicylate	41-58	interleukin 1 beta	Homo sapiens	84-88
10328874-3	1999	We found that two members of the NSAIDs, sodium salicylate and sulindac repress the IL1B promoter to similar degree to heat shock or HSF1 overexpression.	Sulindac	63-71	interleukin 1 beta	Homo sapiens	84-88
10328874-4	1999	In addition, sodium salicylate and additional NSAIDs used at concentrations that activate HSF1 also inhibited the expression of other monocytic genes (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, ICAM-1) activated by exposure to a pro-inflammatory stimulus (lipopolysaccharide, LPS).	Sodium Salicylate	13-30	interleukin 1 beta	Homo sapiens	162-170
10332966-12	1999	RP-HPLC analysis showed that interleukin 4 (IL-4) increased 15-HETE production (2.4-fold); we also observed an increase in 15-HETE production (1.2-fold) after incubation of the cells with IL-1beta.	15-Hete	123-130	interleukin 1 beta	Homo sapiens	188-196
10219527-8	1999	In the whole blood model, clodronate MS attenuated endotoxin-induced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) release, and the attenuation by the microencapsulated form of clodronate was also more effective than the free (solution) form of clodronate.	Clodronic Acid	26-36	interleukin 1 beta	Homo sapiens	113-131
10219527-8	1999	In the whole blood model, clodronate MS attenuated endotoxin-induced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) release, and the attenuation by the microencapsulated form of clodronate was also more effective than the free (solution) form of clodronate.	Clodronic Acid	26-36	interleukin 1 beta	Homo sapiens	133-142
10219527-8	1999	In the whole blood model, clodronate MS attenuated endotoxin-induced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) release, and the attenuation by the microencapsulated form of clodronate was also more effective than the free (solution) form of clodronate.	Clodronic Acid	206-216	interleukin 1 beta	Homo sapiens	113-131
10219527-8	1999	In the whole blood model, clodronate MS attenuated endotoxin-induced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) release, and the attenuation by the microencapsulated form of clodronate was also more effective than the free (solution) form of clodronate.	Clodronic Acid	206-216	interleukin 1 beta	Homo sapiens	113-131
10755257-10	1999	There was a significant reduction in IL-1beta levels in the supernatant of coeliac biopsies cultured with FFIII compared to culture medium alone (P&lt; 0.05), but when cultured with FFIII and L-NMMA there was a significant increase in IL-1beta levels (P&lt; 0.05).	ffiii	106-111	interleukin 1 beta	Homo sapiens	37-45
10755257-10	1999	There was a significant reduction in IL-1beta levels in the supernatant of coeliac biopsies cultured with FFIII compared to culture medium alone (P&lt; 0.05), but when cultured with FFIII and L-NMMA there was a significant increase in IL-1beta levels (P&lt; 0.05).	ffiii	106-111	interleukin 1 beta	Homo sapiens	235-243
10422725-0	1999	Inhibition of cAMP-mediated decidualization in human endometrial stromal cells by IL-1beta and laminin.	Cyclic AMP	14-18	interleukin 1 beta	Homo sapiens	82-90
10422725-5	1999	Both IL-1beta and laminin were found to inhibit 8-Br-cAMP-induced decidualization in vitro in human endometrial stromal cells.	8-Bromo Cyclic Adenosine Monophosphate	48-57	interleukin 1 beta	Homo sapiens	5-13
10422725-7	1999	These results indicate that IL-1beta and laminin additively and mutually inhibit cAMP-mediated decidualization signals, and that they may inhibit these signals through different mechanisms.	Cyclic AMP	81-85	interleukin 1 beta	Homo sapiens	28-36
10232679-5	1999	Oligonucleotide decoy experiments confirmed the importance of nuclear factor kappaB (NF-kappaB) activation for COX-2 induction by IL-1beta/TNF-alpha.	Oligonucleotides	0-15	interleukin 1 beta	Homo sapiens	130-138
10361385-0	1999	Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo.	gamma-Linolenic Acid	11-30	interleukin 1 beta	Homo sapiens	34-84
10361385-4	1999	METHODS: We examined the influence of gammalinolenic acid added to cells in vitro and administered orally in vivo on interleukin-1 beta and tumor necrosis factor-alpha secretion from activated human peripheral blood monocytes.	gamma-Linolenic Acid	38-57	interleukin 1 beta	Homo sapiens	117-167
10344598-1	1999	A recent study revealed that ceramide acts as a second messenger in the sphingomyelin pathway and thus plays an important regulatory role in programmed cell death (apoptosis) to cell the lines induced by tumor-necrosis factor (TNF)-alpha and interleukin (IL)-1beta, although its effect remains controversial regarding primary neuronal culture.	Ceramides	29-37	interleukin 1 beta	Homo sapiens	242-264
10391095-8	1999	Furthermore, neutralizing antibodies to IL-6 or IL-6 receptor abrogated the antiproliferative effects of IL-1beta- and TNF-alpha-pretreated WI-38 conditioned medium.	wi-38	140-145	interleukin 1 beta	Homo sapiens	105-113
10233156-6	1999	Treatment of monocytes with the sulfonylurea glibenclamide inhibits both IL-1beta secretion and vesicular accumulation, suggesting that this drug prevents the translocation of proIL-1beta from the cytosol into the vesicles.	Sulfonylurea Compounds	32-44	interleukin 1 beta	Homo sapiens	73-81
10233156-6	1999	Treatment of monocytes with the sulfonylurea glibenclamide inhibits both IL-1beta secretion and vesicular accumulation, suggesting that this drug prevents the translocation of proIL-1beta from the cytosol into the vesicles.	Sulfonylurea Compounds	32-44	interleukin 1 beta	Homo sapiens	176-187
10233156-6	1999	Treatment of monocytes with the sulfonylurea glibenclamide inhibits both IL-1beta secretion and vesicular accumulation, suggesting that this drug prevents the translocation of proIL-1beta from the cytosol into the vesicles.	Glyburide	45-58	interleukin 1 beta	Homo sapiens	73-81
10233156-6	1999	Treatment of monocytes with the sulfonylurea glibenclamide inhibits both IL-1beta secretion and vesicular accumulation, suggesting that this drug prevents the translocation of proIL-1beta from the cytosol into the vesicles.	Glyburide	45-58	interleukin 1 beta	Homo sapiens	176-187
10344598-1	1999	A recent study revealed that ceramide acts as a second messenger in the sphingomyelin pathway and thus plays an important regulatory role in programmed cell death (apoptosis) to cell the lines induced by tumor-necrosis factor (TNF)-alpha and interleukin (IL)-1beta, although its effect remains controversial regarding primary neuronal culture.	Sphingomyelins	72-85	interleukin 1 beta	Homo sapiens	242-264
10233156-7	1999	A high concentration of extracellular ATP and hypotonic medium increase secretion of IL-1beta but deplete the vesicular proIL-1beta content, indicating that exocytosis of proIL-1beta-containing vesicles is regulated by ATP and osmotic conditions.	Adenosine Triphosphate	38-41	interleukin 1 beta	Homo sapiens	85-93
10233156-7	1999	A high concentration of extracellular ATP and hypotonic medium increase secretion of IL-1beta but deplete the vesicular proIL-1beta content, indicating that exocytosis of proIL-1beta-containing vesicles is regulated by ATP and osmotic conditions.	Adenosine Triphosphate	38-41	interleukin 1 beta	Homo sapiens	120-131
10233156-7	1999	A high concentration of extracellular ATP and hypotonic medium increase secretion of IL-1beta but deplete the vesicular proIL-1beta content, indicating that exocytosis of proIL-1beta-containing vesicles is regulated by ATP and osmotic conditions.	Adenosine Triphosphate	38-41	interleukin 1 beta	Homo sapiens	171-182
10233156-7	1999	A high concentration of extracellular ATP and hypotonic medium increase secretion of IL-1beta but deplete the vesicular proIL-1beta content, indicating that exocytosis of proIL-1beta-containing vesicles is regulated by ATP and osmotic conditions.	Adenosine Triphosphate	219-222	interleukin 1 beta	Homo sapiens	171-182
10433158-7	1999	Combined stimulation by high glucose or spent dialysate, together with IL-1beta or TNFalpha, showed a greater increase in TGFbeta1 mRNA expression and protein secretion compared to stimulation by high glucose or spent dialysate alone.	Glucose	201-208	interleukin 1 beta	Homo sapiens	71-79
10329302-4	1999	The objective of this study was to evaluate the effect of diacerein, a new anti-OA agent and its active metabolite, rhein, on the production and function of IL-1beta, nitric oxide (NO) and receptor agonist (IL-1ra) in human OA cartilage and synovial tissue cultures.	diacerein	58-67	interleukin 1 beta	Homo sapiens	157-165
10329302-8	1999	RESULTS: Diacerein and rhein, as well as hydrocortisone, significantly inhibited LPS-induced IL-1beta production by synovial tissue and cartilage.	diacerein	9-18	interleukin 1 beta	Homo sapiens	93-101
10329302-8	1999	RESULTS: Diacerein and rhein, as well as hydrocortisone, significantly inhibited LPS-induced IL-1beta production by synovial tissue and cartilage.	Hydrocortisone	41-55	interleukin 1 beta	Homo sapiens	93-101
10329302-12	1999	CONCLUSION: An inhibitory effect of diacerein and rhein at therapeutic concentrations on both IL-1beta secretion and function in human synovial tissue and cartilage is suggested.	diacerein	36-45	interleukin 1 beta	Homo sapiens	94-102
10375961-10	1999	The intravenous administration of IL-1 beta increased the urinary sodium excretion.	Sodium	66-72	interleukin 1 beta	Homo sapiens	34-43
10425885-0	1999	[Effect of naproxen sodium on serum concentrations of IL-1, IL-6, and TNF in patients with acute, purulent pharyngo-tonsillitis].	Naproxen	11-26	interleukin 1 beta	Homo sapiens	54-58
10425885-3	1999	OBJECTIVE: Assess the effect of sodium naproxen on the serum concentration of IL-1, IL-6 and TNF in acute infectious process.	Naproxen	32-47	interleukin 1 beta	Homo sapiens	78-82
10425885-9	1999	DISCUSSION: Patients receiving treatment with sodium naproxen had a statistically significant reduction of the serum concentration of IL-1b as compared to basal and 72 h measurements; there were also statistically significant differences with respect to patients receiving placebo.	Naproxen	46-61	interleukin 1 beta	Homo sapiens	134-139
10425885-11	1999	These results show that serum IL-1b levels dropped in both groups with a more striking reduction in the group receiving sodium naproxen , that also showed a faster improvement of the symptoms.	Naproxen	120-135	interleukin 1 beta	Homo sapiens	30-35
10375961-11	1999	The pretreatement of HS142-1, an ANH antagonist, abolished the increase in urinary sodium excretion induced by IL-1 beta.	Sodium	83-89	interleukin 1 beta	Homo sapiens	111-120
10198199-3	1999	Expression of IL-1beta or PAI-2 mRNA in response to TCDD was increased in a dose-dependent fashion.	Polychlorinated Dibenzodioxins	52-56	interleukin 1 beta	Homo sapiens	14-22
10220459-3	1999	Aspirin and sodium salicylate at therapeutic concentrations equipotently blocked COX-2 mRNA and protein levels induced by interleukin-1beta and phorbol 12-myristate 13-acetate.	Aspirin	0-7	interleukin 1 beta	Homo sapiens	122-139
10220459-3	1999	Aspirin and sodium salicylate at therapeutic concentrations equipotently blocked COX-2 mRNA and protein levels induced by interleukin-1beta and phorbol 12-myristate 13-acetate.	Sodium Salicylate	12-29	interleukin 1 beta	Homo sapiens	122-139
10198199-4	1999	The maximum increases of PAI-2 and IL-1beta mRNAs were observed at 100 and 10 nM TCDD, respectively.	Polychlorinated Dibenzodioxins	81-85	interleukin 1 beta	Homo sapiens	35-43
10198199-8	1999	The results demonstrated that IL-1beta and PAI-2 genes are induced dose dependently in human endometrial cells with exposure to TCDD and expression of PAI-2 mRNA is controlled at the posttranscriptional level.	Polychlorinated Dibenzodioxins	128-132	interleukin 1 beta	Homo sapiens	30-38
10202024-5	1999	Our results showed that HCMV binding to monocytes resulted in the production and release of IL-1beta protein.	hcmv	24-28	interleukin 1 beta	Homo sapiens	92-100
10202030-2	1999	To help elucidate the mechanisms involved in IL-1 beta processing and release, we measured IL-1 beta forms released from endotoxin-stimulated monocytes by immunoprecipitation of [35S]methionine-labeled protein, by Western blots, and by our recently developed ELISA specific for proIL-1 beta.	Methionine	183-193	interleukin 1 beta	Homo sapiens	91-100
10202030-4	1999	The 31-kDa-released form of proIL-1 beta represented 20-40% of the total released IL-1 beta, as measured by SDS-PAGE with densitometry.	Sodium Dodecyl Sulfate	108-111	interleukin 1 beta	Homo sapiens	28-40
10202030-4	1999	The 31-kDa-released form of proIL-1 beta represented 20-40% of the total released IL-1 beta, as measured by SDS-PAGE with densitometry.	Sodium Dodecyl Sulfate	108-111	interleukin 1 beta	Homo sapiens	31-40
10203300-3	1999	A novel pre-assay treatment using Frigen II was introduced to improve the recovery rates of cytokines, i.e., interleukin-1alpha, interleukin-1beta and interleukin-1 receptor antagonist, prior to ELISA assay.	frigen ii	34-43	interleukin 1 beta	Homo sapiens	129-146
10199864-0	1999	COX-2 and cytosolic PLA2 mediate IL-1beta-induced cAMP production in human vascular smooth muscle cells.	Cyclic AMP	50-54	interleukin 1 beta	Homo sapiens	33-41
10198245-6	1999	Furthermore, the COX-2 specific inhibitor, NS-398, abolished the PGE2 production induced by IL-1beta, EGF, or the combination.	Dinoprostone	65-69	interleukin 1 beta	Homo sapiens	92-100
10198245-7	1999	These results indicate that the synergy between IL-1beta and EGF on PGE2 production is due to an enhanced gene expression of COX-2 and that tyrosine kinase(s) are involved in the signal transduction of COX-2 in gingival fibroblasts.	Dinoprostone	68-72	interleukin 1 beta	Homo sapiens	48-56
10198245-0	1999	Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor.	Dinoprostone	65-81	interleukin 1 beta	Homo sapiens	139-156
10198245-3	1999	Simultaneous treatment with EGF and IL-1beta resulted in enhanced COX-2 mRNA levels accompanied by a synergistic stimulation of PGE2 biosynthesis compared to the cells treated with IL-1beta or EGF alone.	Dinoprostone	128-132	interleukin 1 beta	Homo sapiens	36-44
10198245-5	1999	The tyrosine kinase inhibitors, Herbimycin A and PD 153035 hydrochloride, reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta or the combination of IL-1beta and EGF whereas COX-1 mRNA levels were not affected.	herbimycin	32-44	interleukin 1 beta	Homo sapiens	138-146
10198245-5	1999	The tyrosine kinase inhibitors, Herbimycin A and PD 153035 hydrochloride, reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta or the combination of IL-1beta and EGF whereas COX-1 mRNA levels were not affected.	herbimycin	32-44	interleukin 1 beta	Homo sapiens	169-177
10198245-5	1999	The tyrosine kinase inhibitors, Herbimycin A and PD 153035 hydrochloride, reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta or the combination of IL-1beta and EGF whereas COX-1 mRNA levels were not affected.	Dinoprostone	111-115	interleukin 1 beta	Homo sapiens	138-146
10198245-6	1999	Furthermore, the COX-2 specific inhibitor, NS-398, abolished the PGE2 production induced by IL-1beta, EGF, or the combination.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	43-49	interleukin 1 beta	Homo sapiens	92-100
10195945-0	1999	Alpha-tocopherol decreases interleukin-1 beta release from activated human monocytes by inhibition of 5-lipoxygenase.	alpha-Tocopherol	0-16	interleukin 1 beta	Homo sapiens	27-45
10195945-4	1999	The reduction in superoxide and lipid oxidation by AT seemed to be mediated by inhibition of protein kinase C. The aim of this study was to investigate the mechanism(s) by which AT inhibits IL-1 beta release.	Superoxides	17-27	interleukin 1 beta	Homo sapiens	190-199
10195945-10	1999	In the presence of AT, a significant reduction in leukotriene B4 and IL-1 beta levels was observed, which was reversed by the addition of leukotriene B4.	alpha-Tocopherol	19-21	interleukin 1 beta	Homo sapiens	69-78
10195945-12	1999	The product of cyclooxygenase, prostaglandin E2, has been shown to inhibit IL-1 beta activity in some systems.	Dinoprostone	31-47	interleukin 1 beta	Homo sapiens	75-84
10195945-14	1999	In the presence of indomethacin, a cyclooxygenase inhibitor, AT inhibited IL-1 beta activity.	Indomethacin	19-31	interleukin 1 beta	Homo sapiens	74-83
10334387-2	1999	In the study of IL-1beta degradation, fluorescein isothiocyanate (FITC)-labeled IL-1beta was used as a substrate.	Fluorescein-5-isothiocyanate	38-64	interleukin 1 beta	Homo sapiens	80-88
10223396-6	1999	Additionally, OAS-1000 was tested for it"s ability inhibit 1 ng/ml IL-1beta stimulated PGE2 production in a cell culture system.	Dinoprostone	87-91	interleukin 1 beta	Homo sapiens	67-75
10334387-2	1999	In the study of IL-1beta degradation, fluorescein isothiocyanate (FITC)-labeled IL-1beta was used as a substrate.	Fluorescein-5-isothiocyanate	66-70	interleukin 1 beta	Homo sapiens	80-88
10527453-6	1999	When DITNC cells were prelabeled with [32P]Pi, an increase in labeled phosphatidic acid (PA) was observed on treatment of cells with IL-1beta (200 U/mL).	Phosphorus-32	39-42	interleukin 1 beta	Homo sapiens	133-141
10334387-6	1999	N-Ethylmaleimide, leupeptin and E-64, inhibitors of thiol protease, inhibited the degradation of IL-1beta, by 59%-70%.	Ethylmaleimide	0-16	interleukin 1 beta	Homo sapiens	97-105
10527453-6	1999	When DITNC cells were prelabeled with [32P]Pi, an increase in labeled phosphatidic acid (PA) was observed on treatment of cells with IL-1beta (200 U/mL).	Phosphatidic Acids	70-87	interleukin 1 beta	Homo sapiens	133-141
10527453-6	1999	When DITNC cells were prelabeled with [32P]Pi, an increase in labeled phosphatidic acid (PA) was observed on treatment of cells with IL-1beta (200 U/mL).	Phosphatidic Acids	89-91	interleukin 1 beta	Homo sapiens	133-141
10334387-6	1999	N-Ethylmaleimide, leupeptin and E-64, inhibitors of thiol protease, inhibited the degradation of IL-1beta, by 59%-70%.	leupeptin	18-27	interleukin 1 beta	Homo sapiens	97-105
10527453-7	1999	However, despite the ability of phorbol myristate acetate (PMA) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells, PLD activity was not affected by IL-1beta.	Tetradecanoylphorbol Acetate	59-62	interleukin 1 beta	Homo sapiens	191-199
10408016-8	1999	These results suggest that both, IL-1 beta and IL-1 alpha, stimulate GAG and especially hyaluronic acid synthesis, but not DNA synthesis, in vitro.	Glycosaminoglycans	69-72	interleukin 1 beta	Homo sapiens	33-42
10527458-5	1999	However, the known PKC inhibitors such as H-7 or staurosporine, partially inhibited the elevation of sAPP alpha secretion in response to protein kinase C (PKC) agonist phorbol 12,13-dibutyrate (PdBu) as well as to IL-1beta, mimicking the immunosuppressive gp41 peptide.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	42-45	interleukin 1 beta	Homo sapiens	214-222
10527458-5	1999	However, the known PKC inhibitors such as H-7 or staurosporine, partially inhibited the elevation of sAPP alpha secretion in response to protein kinase C (PKC) agonist phorbol 12,13-dibutyrate (PdBu) as well as to IL-1beta, mimicking the immunosuppressive gp41 peptide.	Staurosporine	49-62	interleukin 1 beta	Homo sapiens	214-222
10443964-8	1999	Natural killer cell activity and in vitro secretion of interleukin-1beta and tumor necrosis factor alpha were significantly reduced by DHA feeding.	Docosahexaenoic Acids	135-138	interleukin 1 beta	Homo sapiens	55-104
10397405-4	1999	The effect of dexamethasone on IL-1beta and PMA induced promoter activities was further examined.	Dexamethasone	14-27	interleukin 1 beta	Homo sapiens	31-39
10397405-5	1999	IL-1beta or PMA induced activity was blocked by dexamethasone, whereas IL-1beta or PMA induced mutant activity was not responsive to dexamethasone.	Dexamethasone	48-61	interleukin 1 beta	Homo sapiens	0-8
10408016-3	1999	Stimulation with 100 or 200 pg/ml IL-1 beta led to a relative increase (total GAGs: 100%) in hyaluronic acid from 49% to 64 (-FCS) and from 79% to 92% (+10% FCS), respectively.	Hyaluronic Acid	93-108	interleukin 1 beta	Homo sapiens	34-43
10408016-6	1999	Compared to young (Phase II) cells senescent (Phase III) cells showed significantly diminished stimulation of hyaluronic acid synthesis by IL-1 beta.	Hyaluronic Acid	110-125	interleukin 1 beta	Homo sapiens	139-148
10408016-8	1999	These results suggest that both, IL-1 beta and IL-1 alpha, stimulate GAG and especially hyaluronic acid synthesis, but not DNA synthesis, in vitro.	Hyaluronic Acid	88-103	interleukin 1 beta	Homo sapiens	33-42
10037458-4	1999	The PKC inhibitor calphostin C inhibited NF-kappaB activation by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta in Jurkat or NIH3T3 cells but not in MCF7 A/Z cells.	calphostin C	18-30	interleukin 1 beta	Homo sapiens	102-124
10225377-4	1999	We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes.	trifluoromethylketone	30-51	interleukin 1 beta	Homo sapiens	104-121
10092052-4	1999	The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta.	Tetradecanoylphorbol Acetate	114-145	interleukin 1 beta	Homo sapiens	28-36
10092052-4	1999	The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta.	Tetradecanoylphorbol Acetate	147-150	interleukin 1 beta	Homo sapiens	28-36
10092052-4	1999	The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta.	Tetradecanoylphorbol Acetate	162-165	interleukin 1 beta	Homo sapiens	28-36
10070000-7	1999	N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone, a broad-spectrum caspase inhibitor, prevented morphological features of necrosis, plasma membrane destruction, loss of mitochondrial membrane potential, IL-1beta release, and CD14 shedding induced by all stimuli.	Caspase Inhibitor VI	0-51	interleukin 1 beta	Homo sapiens	206-214
10049276-5	1999	In the control group (no CLDM), CAZ administration resulted in significant increases in endotoxin, TNF-alpha, and IL-1 beta concentrations.	Ceftazidime	32-35	interleukin 1 beta	Homo sapiens	114-123
10342040-12	1999	Nimesulide inhibited PGE2 production by unstimulated (IC50 = 6 ng/ml) and IL-1 beta-stimulated (IC50 = 6.9 ng/ml) chondrocytes.	nimesulide	0-10	interleukin 1 beta	Homo sapiens	74-83
10342040-14	1999	Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta-stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production.	nimesulide	18-28	interleukin 1 beta	Homo sapiens	114-123
10342040-14	1999	Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta-stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production.	Diclofenac	33-43	interleukin 1 beta	Homo sapiens	114-123
10435048-5	1999	RESULTS: IL-1 beta increased basal NO-induced dilatation in the study vein, and this was sufficient to attenuate the constrictor response to exogenous noradrenaline or sympathetic stimulation.	Norepinephrine	151-164	interleukin 1 beta	Homo sapiens	9-18
10435048-6	1999	The effects were maximal at 6 h and both NG-monomethyl-L-arginine and aminoguanidine caused significant reversal of the IL-1 beta effects.	omega-N-Methylarginine	41-65	interleukin 1 beta	Homo sapiens	120-129
10435048-6	1999	The effects were maximal at 6 h and both NG-monomethyl-L-arginine and aminoguanidine caused significant reversal of the IL-1 beta effects.	pimagedine	70-84	interleukin 1 beta	Homo sapiens	120-129
10435048-9	1999	CONCLUSION: The simplest explanation of these results is that IL-1 beta induces expression of GTP cyclohydrolase-1 which leads to increased generation of BH4 and activation of eNOS.	sapropterin	154-157	interleukin 1 beta	Homo sapiens	62-71
10209072-3	1999	In this study, the authors compared the effect of CRF on IL-1alpha- and IL-1beta-induced PG synthesis.	Prostaglandins	89-91	interleukin 1 beta	Homo sapiens	72-80
10209072-7	1999	IL- 1beta (100 U/ml) was as active as IL-1alpha in triggering release of PGI2 from endothelial cells and PGE2 from fibroblasts.	Epoprostenol	73-77	interleukin 1 beta	Homo sapiens	0-9
10209072-7	1999	IL- 1beta (100 U/ml) was as active as IL-1alpha in triggering release of PGI2 from endothelial cells and PGE2 from fibroblasts.	Dinoprostone	105-109	interleukin 1 beta	Homo sapiens	0-9
10049276-6	1999	Pretreatment of E. coli with CLDM for 4 or 18 h before the addition of CAZ significantly suppressed the concentrations of endotoxin, TNF-alpha, and IL-1 beta in a time-dependent manner.	Clindamycin	29-33	interleukin 1 beta	Homo sapiens	148-157
10021319-4	1999	Activation of the p38-MAPK cascade by a short stimulation (10 min) with the NO donor MAHMA-NO causes a large increase in ATF2 phosphorylation that is several times greater than that observed after stimulation with interleukin-1beta, a well-known activator of the p38-MAPK pathway.	MAHMA-NO	85-93	interleukin 1 beta	Homo sapiens	214-231
10232419-10	1999	One explanation for the increase in pleural fluid hyaluronan may be local production of proinflammatory cytokines, such as tumour necrosis factor-alpha and interleukin-1beta.	Hyaluronic Acid	50-60	interleukin 1 beta	Homo sapiens	156-173
10022520-9	1999	Addition of IL-1beta to GM-CSF-stimulated cultures dampened the inhibitory effect of 1,25(OH)2D3.	Calcitriol	85-96	interleukin 1 beta	Homo sapiens	12-20
10076187-3	1999	Treatment with IL-1beta enhanced media accumulation of nitrites (4.8-fold), prostaglandin E2 (PGE2, 3.	Nitrites	55-63	interleukin 1 beta	Homo sapiens	15-23
10076187-3	1999	Treatment with IL-1beta enhanced media accumulation of nitrites (4.8-fold), prostaglandin E2 (PGE2, 3.	Dinoprostone	76-92	interleukin 1 beta	Homo sapiens	15-23
10076187-3	1999	Treatment with IL-1beta enhanced media accumulation of nitrites (4.8-fold), prostaglandin E2 (PGE2, 3.	Dinoprostone	94-98	interleukin 1 beta	Homo sapiens	15-23
10076187-7	1999	However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner.	Nitrites	64-71	interleukin 1 beta	Homo sapiens	44-52
10076187-7	1999	However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner.	Dinoprostone	80-84	interleukin 1 beta	Homo sapiens	44-52
10076187-7	1999	However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner.	Lactic Acid	95-102	interleukin 1 beta	Homo sapiens	44-52
10198191-5	1999	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta.	Genistein	113-122	interleukin 1 beta	Homo sapiens	0-9
10076187-7	1999	However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner.	Glucose	156-163	interleukin 1 beta	Homo sapiens	44-52
10076187-7	1999	However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner.	Glucose	156-163	interleukin 1 beta	Homo sapiens	136-144
10198191-5	1999	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta.	Genistein	113-122	interleukin 1 beta	Homo sapiens	318-327
10198191-5	1999	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta.	Staurosporine	172-184	interleukin 1 beta	Homo sapiens	0-9
10198191-5	1999	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta.	calphostin C	186-198	interleukin 1 beta	Homo sapiens	0-9
10027847-3	1999	We addressed this question by using radioimmunoassay to measure PGE2 release by human cells (A549) induced to express cyclooxygenase-2 (measured by Western blot analysis) by interleukin-1beta.	Dinoprostone	64-68	interleukin 1 beta	Homo sapiens	174-191
10198191-5	1999	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta.	Phorbol Esters	203-216	interleukin 1 beta	Homo sapiens	0-9
10198191-9	1999	In addition, pre-treatment of CMEC by IL-1 beta markedly enhanced VEGF-induced tyrosine phosphorylation of focal adhesion kinase compared with that in the unstimulated cells.	Tyrosine	79-87	interleukin 1 beta	Homo sapiens	38-47
10068525-10	1999	RESULTS: TLCK, genistein, and LLnL each inhibited IL-1beta-induced C3 production in a dose-dependent fashion.	Genistein	15-24	interleukin 1 beta	Homo sapiens	50-58
10225546-4	1999	The aim of this study was to investigate the effects of CsA on the production of 2 cytokines - interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) - by both gingival fibroblasts and peripheral blood mononuclear cells (PBMC).	Cyclosporine	56-59	interleukin 1 beta	Homo sapiens	95-112
10225546-4	1999	The aim of this study was to investigate the effects of CsA on the production of 2 cytokines - interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) - by both gingival fibroblasts and peripheral blood mononuclear cells (PBMC).	Cyclosporine	56-59	interleukin 1 beta	Homo sapiens	114-122
10225546-10	1999	CsA inhibited IL-1beta production by PBMC over the whole concentration range (P &lt;0.05).	Cyclosporine	0-3	interleukin 1 beta	Homo sapiens	14-22
10090171-8	1999	The cellular release of IL-1beta, TNF-alpha, and IL-6 was elevated in response to bleomycin exposure in both controls and patients with SSc.	Bleomycin	82-91	interleukin 1 beta	Homo sapiens	24-32
10221733-2	1999	Previous studies of reproductive-aged women demonstrated that IgA and IgG increases in cervical mucus corresponded to elevated levels of IL-1beta which occurred 1 day before the peak of endogenous estradiol production prior to ovulation.	Estradiol	197-206	interleukin 1 beta	Homo sapiens	137-145
10068525-0	1999	Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha.	Serine	152-155	interleukin 1 beta	Homo sapiens	38-46
10232875-3	1999	METHODS: Adenosine 5"-triphosphate (ATP) levels in HT29 cells cultured with LPS, IL-1beta, IL-6, or TNF-alpha were measured with high-performance liquid chromatography, using a reversed-phase chromatography column.	Adenosine Triphosphate	36-39	interleukin 1 beta	Homo sapiens	81-89
10022882-0	1999	Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity.	reactive oxygen	0-15	interleukin 1 beta	Homo sapiens	63-80
10221733-8	1999	IgA, IgG and IL-1beta levels in women on OCPs paralleled increasing levels of norethindrone.	Norethindrone	78-91	interleukin 1 beta	Homo sapiens	13-21
10211608-8	1999	IL-1beta dose-dependently increased [3H]glucosamine incorporation into GAG by both cells.	Glycosaminoglycans	71-74	interleukin 1 beta	Homo sapiens	0-8
10102472-4	1999	However, in the ER expressing cells the ability of IL-1beta to increase PAI-1 mRNA and protein levels was attenuated by 17beta-estradiol, tamoxifen and twelve estrogen components of Premarin.	Estradiol	120-136	interleukin 1 beta	Homo sapiens	51-59
10102472-4	1999	However, in the ER expressing cells the ability of IL-1beta to increase PAI-1 mRNA and protein levels was attenuated by 17beta-estradiol, tamoxifen and twelve estrogen components of Premarin.	Tamoxifen	138-147	interleukin 1 beta	Homo sapiens	51-59
10102472-5	1999	In contrast, the mixed agonist/antagonist raloxifene had weak agonist activity and like the pure antagonist ICI 182780, it dose dependently blocked the effect of 17beta-estradiol on IL-1beta stimulated PAI-1 levels.	Raloxifene Hydrochloride	42-52	interleukin 1 beta	Homo sapiens	182-190
10102472-5	1999	In contrast, the mixed agonist/antagonist raloxifene had weak agonist activity and like the pure antagonist ICI 182780, it dose dependently blocked the effect of 17beta-estradiol on IL-1beta stimulated PAI-1 levels.	Fulvestrant	108-118	interleukin 1 beta	Homo sapiens	182-190
10102472-5	1999	In contrast, the mixed agonist/antagonist raloxifene had weak agonist activity and like the pure antagonist ICI 182780, it dose dependently blocked the effect of 17beta-estradiol on IL-1beta stimulated PAI-1 levels.	Estradiol	162-178	interleukin 1 beta	Homo sapiens	182-190
10211608-0	1999	Oxygen free radicals in interleukin-1beta-induced glycosaminoglycan production by retro-ocular fibroblasts from normal subjects and Graves" ophthalmopathy patients.	oxygen free radicals	0-20	interleukin 1 beta	Homo sapiens	24-41
10211608-3	1999	In the present study, we investigated interleukin (IL)-1beta-induced oxygen free radical production and the role of oxygen free radicals in IL-1beta-induced GAG production in retro-ocular fibroblasts from both normal subjects and patients with GO.	Oxygen	69-75	interleukin 1 beta	Homo sapiens	38-60
10211608-3	1999	In the present study, we investigated interleukin (IL)-1beta-induced oxygen free radical production and the role of oxygen free radicals in IL-1beta-induced GAG production in retro-ocular fibroblasts from both normal subjects and patients with GO.	Free Radicals	76-88	interleukin 1 beta	Homo sapiens	38-60
10211608-3	1999	In the present study, we investigated interleukin (IL)-1beta-induced oxygen free radical production and the role of oxygen free radicals in IL-1beta-induced GAG production in retro-ocular fibroblasts from both normal subjects and patients with GO.	oxygen free radicals	116-136	interleukin 1 beta	Homo sapiens	140-148
10211608-10	1999	Scavenging oxygen free radicals by the use of SOD (100 U/mL) and catalase (300 U/mL) partially blocked the IL-1beta-induced GAG production in both cells.	oxygen free radicals	11-31	interleukin 1 beta	Homo sapiens	107-115
10211608-3	1999	In the present study, we investigated interleukin (IL)-1beta-induced oxygen free radical production and the role of oxygen free radicals in IL-1beta-induced GAG production in retro-ocular fibroblasts from both normal subjects and patients with GO.	Glycosaminoglycans	157-160	interleukin 1 beta	Homo sapiens	140-148
10211608-5	1999	IL-1beta increased the free radical production in both cells.	Free Radicals	23-35	interleukin 1 beta	Homo sapiens	0-8
10211608-10	1999	Scavenging oxygen free radicals by the use of SOD (100 U/mL) and catalase (300 U/mL) partially blocked the IL-1beta-induced GAG production in both cells.	Glycosaminoglycans	124-127	interleukin 1 beta	Homo sapiens	107-115
10211608-8	1999	IL-1beta dose-dependently increased [3H]glucosamine incorporation into GAG by both cells.	[3h]glucosamine	36-51	interleukin 1 beta	Homo sapiens	0-8
10211608-11	1999	These results suggest that stress related oxygen free radicals are present in the retro-ocular tissue in GO and that oxygen free radicals are involved in GAG accumulation induced by cytokine IL-1beta.	oxygen free radicals	117-137	interleukin 1 beta	Homo sapiens	191-199
10211608-11	1999	These results suggest that stress related oxygen free radicals are present in the retro-ocular tissue in GO and that oxygen free radicals are involved in GAG accumulation induced by cytokine IL-1beta.	Glycosaminoglycans	154-157	interleukin 1 beta	Homo sapiens	191-199
10026206-6	1999	PD98059, an inhibitor of the upstream activator of ERK1/2, the MAP/ERK kinase MEK1/2, suppressed IL-1beta and tumor necrosis factor-alpha production in a dose-dependent fashion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Homo sapiens	97-137
11783286-2	1999	METHODS: A reactive status of hypothalamic monoamine transmitters to cytokine in rat was built by observing the content change of monoamine transmitters in hypothalamic homogenate after intracerebroventricular (icv) injection of human recombinant interleukin-1 beta(IL-1 beta).	monoamine	43-52	interleukin 1 beta	Homo sapiens	247-265
11783286-2	1999	METHODS: A reactive status of hypothalamic monoamine transmitters to cytokine in rat was built by observing the content change of monoamine transmitters in hypothalamic homogenate after intracerebroventricular (icv) injection of human recombinant interleukin-1 beta(IL-1 beta).	monoamine	43-52	interleukin 1 beta	Homo sapiens	266-275
11783286-2	1999	METHODS: A reactive status of hypothalamic monoamine transmitters to cytokine in rat was built by observing the content change of monoamine transmitters in hypothalamic homogenate after intracerebroventricular (icv) injection of human recombinant interleukin-1 beta(IL-1 beta).	monoamine	130-139	interleukin 1 beta	Homo sapiens	247-265
11783286-2	1999	METHODS: A reactive status of hypothalamic monoamine transmitters to cytokine in rat was built by observing the content change of monoamine transmitters in hypothalamic homogenate after intracerebroventricular (icv) injection of human recombinant interleukin-1 beta(IL-1 beta).	monoamine	130-139	interleukin 1 beta	Homo sapiens	266-275
9952427-10	1999	However, pretreatment with either the IL-1 receptor antagonist or the cyclooxygenase inhibitor flurbiprofen completely abolishes adenovirus-induced fever, suggesting that IL-1 and prostaglandins are direct mediators of this response.	Prostaglandins	180-194	interleukin 1 beta	Homo sapiens	38-42
10066641-8	1999	We observed an increased IL-1beta-, IL-6-, IL-8- and TNF-alpha-specific mRNA expression of particle or fibre exposed AM, which was decreased after an additional NO2 exposure.	Nitrogen Dioxide	161-164	interleukin 1 beta	Homo sapiens	25-33
10066641-9	1999	Also the particle or fibre exposure induced significant increase in IL-1beta-, IL-6-, IL-8 and TNF-alpha-release of AM which was decreased after an additional NO2 exposure (p &lt;0.031).	Nitrogen Dioxide	159-162	interleukin 1 beta	Homo sapiens	68-76
10082276-12	1999	Interleukin-1beta dramatically increased prostaglandin E2 production and significantly stimulated hepatocyte growth factor synthesis.	Dinoprostone	41-57	interleukin 1 beta	Homo sapiens	0-17
9933650-7	1999	These results strongly suggested that the oligosaccharides in fraction AR bind to IL-1beta and suppress its cytokine activity.	Oligosaccharides	42-58	interleukin 1 beta	Homo sapiens	82-90
9933650-9	1999	Fractionation of the oligosaccharides indicated that only oligosaccharides containing an N-acetylgalactosamine residue and a sulfate residue bound specifically to IL-1beta.	Oligosaccharides	21-37	interleukin 1 beta	Homo sapiens	163-171
9933650-9	1999	Fractionation of the oligosaccharides indicated that only oligosaccharides containing an N-acetylgalactosamine residue and a sulfate residue bound specifically to IL-1beta.	Oligosaccharides	58-74	interleukin 1 beta	Homo sapiens	163-171
9933650-9	1999	Fractionation of the oligosaccharides indicated that only oligosaccharides containing an N-acetylgalactosamine residue and a sulfate residue bound specifically to IL-1beta.	Acetylgalactosamine	89-110	interleukin 1 beta	Homo sapiens	163-171
9933650-9	1999	Fractionation of the oligosaccharides indicated that only oligosaccharides containing an N-acetylgalactosamine residue and a sulfate residue bound specifically to IL-1beta.	Sulfates	125-132	interleukin 1 beta	Homo sapiens	163-171
9933650-10	1999	Removal of either the sulfate residue or the N-acetylgalactosamine residue from the oligosaccharides abolished both the proliferation-inhibition and IL-1beta binding activities.	Sulfates	22-29	interleukin 1 beta	Homo sapiens	149-157
9933650-10	1999	Removal of either the sulfate residue or the N-acetylgalactosamine residue from the oligosaccharides abolished both the proliferation-inhibition and IL-1beta binding activities.	Acetylgalactosamine	45-66	interleukin 1 beta	Homo sapiens	149-157
9933650-10	1999	Removal of either the sulfate residue or the N-acetylgalactosamine residue from the oligosaccharides abolished both the proliferation-inhibition and IL-1beta binding activities.	Oligosaccharides	84-100	interleukin 1 beta	Homo sapiens	149-157
10091704-2	1999	Podocarpic acid derivatives as cytokine (IL-1beta) release inhibitors are discussed.	podocarpic acid	0-15	interleukin 1 beta	Homo sapiens	41-49
10082276-14	1999	Indomethacin significantly reduced interleukin-1beta-induced prostaglandin E2 release and hepatocyte growth factor production.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	35-52
10082276-14	1999	Indomethacin significantly reduced interleukin-1beta-induced prostaglandin E2 release and hepatocyte growth factor production.	Dinoprostone	61-77	interleukin 1 beta	Homo sapiens	35-52
9933650-11	1999	Since IL-1beta did not bind to thyroid-stimulating hormone, which has the sulfate group at C-4 of the N-acetylgalactosamine residue in its N-linked sugar chains, the binding of IL-1beta toward oligosaccharides in fraction AR was considered to be highly specific.	n-linked sugar	139-153	interleukin 1 beta	Homo sapiens	177-185
10025918-1	1999	OBJECTIVE: Nitric oxide (NO) is generated copiously by articular chondrocytes activated by interleukin-1beta (IL-1beta).	Nitric Oxide	11-23	interleukin 1 beta	Homo sapiens	91-108
9933650-11	1999	Since IL-1beta did not bind to thyroid-stimulating hormone, which has the sulfate group at C-4 of the N-acetylgalactosamine residue in its N-linked sugar chains, the binding of IL-1beta toward oligosaccharides in fraction AR was considered to be highly specific.	Oligosaccharides	193-209	interleukin 1 beta	Homo sapiens	177-185
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Phorbol Esters	52-65	interleukin 1 beta	Homo sapiens	134-142
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	67-98	interleukin 1 beta	Homo sapiens	134-142
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 beta	Homo sapiens	134-142
10207535-4	1999	When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P &lt; 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts.	Dinoprostone	213-217	interleukin 1 beta	Homo sapiens	172-181
10207535-4	1999	When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P &lt; 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts.	Epoprostenol	222-226	interleukin 1 beta	Homo sapiens	78-87
10207535-4	1999	When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P &lt; 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts.	Epoprostenol	222-226	interleukin 1 beta	Homo sapiens	172-181
9974427-4	1999	The data presented herein show that resveratrol, in a dose-dependent manner, inhibited the expression of TF in endothelial cells stimulated with a variety of agonists, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and lipopolysaccharide (LPS).	Resveratrol	36-47	interleukin 1 beta	Homo sapiens	178-195
9974427-4	1999	The data presented herein show that resveratrol, in a dose-dependent manner, inhibited the expression of TF in endothelial cells stimulated with a variety of agonists, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and lipopolysaccharide (LPS).	Resveratrol	36-47	interleukin 1 beta	Homo sapiens	197-205
9974427-6	1999	In addition, resveratrol was shown to inhibit the LPS-induced expression of TNFalpha mRNA in endothelial cells and of TNFalpha and IL-1beta mRNA in monocytes.	Resveratrol	13-24	interleukin 1 beta	Homo sapiens	131-139
10025918-1	1999	OBJECTIVE: Nitric oxide (NO) is generated copiously by articular chondrocytes activated by interleukin-1beta (IL-1beta).	Nitric Oxide	11-23	interleukin 1 beta	Homo sapiens	110-118
10025918-11	1999	When NO synthesis was inhibited with L-NMA, IL-1beta increased CM concentrations of TGFbeta1 from 24-72 hours of culture.	l-nma	37-42	interleukin 1 beta	Homo sapiens	44-52
10063910-5	1999	N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta).	Dimethyl Sulfoxide	26-43	interleukin 1 beta	Homo sapiens	143-151
9890559-2	1999	The anti-inflammatory drug ibuprofen, thought to exert its beneficial effects mainly by suppressing the production of eicosanoids, inhibited the up-regulation of the pro-inflammatory cytokines IL-1beta and TNF-alpha.	Ibuprofen	27-36	interleukin 1 beta	Homo sapiens	193-201
9890559-2	1999	The anti-inflammatory drug ibuprofen, thought to exert its beneficial effects mainly by suppressing the production of eicosanoids, inhibited the up-regulation of the pro-inflammatory cytokines IL-1beta and TNF-alpha.	Eicosanoids	118-129	interleukin 1 beta	Homo sapiens	193-201
10063910-5	1999	N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta).	Acetylcysteine	0-16	interleukin 1 beta	Homo sapiens	124-141
10063910-5	1999	N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta).	Acetylcysteine	0-16	interleukin 1 beta	Homo sapiens	143-151
10063910-5	1999	N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta).	Acetylcysteine	18-21	interleukin 1 beta	Homo sapiens	124-141
10207532-1	1999	The aim of this study was to investigate the effects of a chlorhexidine/thymol-containing dental varnish on the levels of prostaglandin E2 (PGE2), prostaglandin I2 (PGI2), leukotriene B4 (LTB4), and interleukin-1 beta (IL-1 beta) in gingival crevicular fluid (GCF).	Chlorhexidine	58-71	interleukin 1 beta	Homo sapiens	199-217
10207532-1	1999	The aim of this study was to investigate the effects of a chlorhexidine/thymol-containing dental varnish on the levels of prostaglandin E2 (PGE2), prostaglandin I2 (PGI2), leukotriene B4 (LTB4), and interleukin-1 beta (IL-1 beta) in gingival crevicular fluid (GCF).	Chlorhexidine	58-71	interleukin 1 beta	Homo sapiens	219-228
10207535-4	1999	When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P &lt; 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts.	Benzydamine	48-59	interleukin 1 beta	Homo sapiens	78-87
10207535-4	1999	When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P &lt; 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts.	Benzydamine	48-59	interleukin 1 beta	Homo sapiens	172-181
10207535-4	1999	When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P &lt; 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts.	Benzydamine	112-123	interleukin 1 beta	Homo sapiens	78-87
10207535-4	1999	When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P &lt; 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts.	Benzydamine	112-123	interleukin 1 beta	Homo sapiens	172-181
10207535-4	1999	When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P &lt; 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts.	Dinoprostone	213-217	interleukin 1 beta	Homo sapiens	78-87
10063910-5	1999	N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta).	Acetylcysteine	18-21	interleukin 1 beta	Homo sapiens	143-151
10063910-5	1999	N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta).	Dimethyl Sulfoxide	26-43	interleukin 1 beta	Homo sapiens	124-141
10029158-0	1999	IL-1beta mediates diethyldithiocarbamate-induced granulocyte colony-stimulating factor production and hematopoiesis.	Ditiocarb	18-40	interleukin 1 beta	Homo sapiens	0-8
10091607-4	1999	HMC released increased amounts of prostaglandin E2 (PGE2) after treatment with several combinations of IL-1 beta, tumor necrosis factor (TNF)-alpha and/or lipopolysaccharide.	Dinoprostone	34-50	interleukin 1 beta	Homo sapiens	103-112
10091607-4	1999	HMC released increased amounts of prostaglandin E2 (PGE2) after treatment with several combinations of IL-1 beta, tumor necrosis factor (TNF)-alpha and/or lipopolysaccharide.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	103-112
10091607-6	1999	The accumulation of PGE2 elicited by a combination of IL-1 beta/TNF-alpha correlated closely with the temporal pattern of COX-2 protein expression, which reflected the induction of COX-2 mRNA.	Dinoprostone	20-24	interleukin 1 beta	Homo sapiens	54-63
10091607-7	1999	IL-13 inhibited IL-1 beta/TNF-alpha-elicited PGE2 production, as well as COX-2 protein and mRNA expression in a concentration-dependent fashion.	Dinoprostone	45-49	interleukin 1 beta	Homo sapiens	16-25
9922315-6	1999	Forskolin mimicked the stimulatory effects of these neurotransmitters on IL-6 secretion, and the protein kinase inhibitor6-22 amide abolished the actions of VIP, CGRP, and norepinephrine, but not that of human recombinant IL-1beta, on IL-6 secretion.	-22 amide	122-131	interleukin 1 beta	Homo sapiens	222-230
10029158-2	1999	The mechanism of DDTC-mediated chemoprotection is believed to involve the induction and release of several cytokines, including interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and granulocyte colony-stimulating factor (G-CSF).	Ditiocarb	17-21	interleukin 1 beta	Homo sapiens	128-146
10029158-2	1999	The mechanism of DDTC-mediated chemoprotection is believed to involve the induction and release of several cytokines, including interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and granulocyte colony-stimulating factor (G-CSF).	Ditiocarb	17-21	interleukin 1 beta	Homo sapiens	148-156
10029158-4	1999	Administration of IL-1 receptor antagonist (IL-1ra) to DDTC-treated hLTBMCs obviated the G-CSF induction profile and blocked the resultant colony proliferation, indicating that IL-1beta mediates DDTC-induced G-CSF release and hematopoiesis.	Ditiocarb	55-59	interleukin 1 beta	Homo sapiens	177-185
10029158-4	1999	Administration of IL-1 receptor antagonist (IL-1ra) to DDTC-treated hLTBMCs obviated the G-CSF induction profile and blocked the resultant colony proliferation, indicating that IL-1beta mediates DDTC-induced G-CSF release and hematopoiesis.	Ditiocarb	195-199	interleukin 1 beta	Homo sapiens	177-185
10029158-5	1999	IL-1beta mRNA levels were increased threefold over control following DDTC treatment of hLTBMCs, implying that DDTC induces IL-1beta at the level of transcription.	Ditiocarb	69-73	interleukin 1 beta	Homo sapiens	0-8
10029158-5	1999	IL-1beta mRNA levels were increased threefold over control following DDTC treatment of hLTBMCs, implying that DDTC induces IL-1beta at the level of transcription.	Ditiocarb	69-73	interleukin 1 beta	Homo sapiens	123-131
10029158-5	1999	IL-1beta mRNA levels were increased threefold over control following DDTC treatment of hLTBMCs, implying that DDTC induces IL-1beta at the level of transcription.	Ditiocarb	110-114	interleukin 1 beta	Homo sapiens	0-8
10029158-5	1999	IL-1beta mRNA levels were increased threefold over control following DDTC treatment of hLTBMCs, implying that DDTC induces IL-1beta at the level of transcription.	Ditiocarb	110-114	interleukin 1 beta	Homo sapiens	123-131
10029158-7	1999	These findings taken together strongly suggest that IL-1beta mediates the chemoprotective effects of DDTC.	Ditiocarb	101-105	interleukin 1 beta	Homo sapiens	52-60
10065757-0	1999	Interleukin-4 and interferon-gamma inhibit prostaglandin production by interleukin-1beta-stimulated human periodontal ligament fibroblasts.	Prostaglandins	43-56	interleukin 1 beta	Homo sapiens	71-88
10090397-3	1999	Using a three-cytokine mixture (TNF-alpha, IL-1beta, and IFN-gamma) that could maximally induce both iNOS and sPLA2, the increase in these mRNA species reached a maximum by 4-8 h, followed by a decline up to 48 h. L-N6-(1-Iminoethyl)lysine acetate (L-NIL) inhibited cytokine-induced NO production with IC50 of 25 microM, but this compound did not affect iNOS mRNA.	l-n6-(1-iminoethyl)lysine acetate	214-247	interleukin 1 beta	Homo sapiens	43-51
10065757-2	1999	IL-1beta-stimulated PDL fibroblasts produced prostaglandin E2 (PGE2) in a time-dependent manner.	Dinoprostone	45-61	interleukin 1 beta	Homo sapiens	0-8
10065757-2	1999	IL-1beta-stimulated PDL fibroblasts produced prostaglandin E2 (PGE2) in a time-dependent manner.	Dinoprostone	63-67	interleukin 1 beta	Homo sapiens	0-8
10065757-3	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated cells.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	134-142
10065757-3	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	57-63	interleukin 1 beta	Homo sapiens	134-142
10065757-3	1999	Indomethacin, a non-selective COX-1/COX-2 inhibitor, and NS-398, a selective COX-2 inhibitor, completely inhibited PGE2 production by IL-1beta-stimulated cells.	Dinoprostone	115-119	interleukin 1 beta	Homo sapiens	134-142
10065757-5	1999	Dexamethasone inhibited COX-2 mRNA expression, COX activity and PGE2 production in IL-1beta-stimulated cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	83-91
10065757-5	1999	Dexamethasone inhibited COX-2 mRNA expression, COX activity and PGE2 production in IL-1beta-stimulated cells.	Dinoprostone	64-68	interleukin 1 beta	Homo sapiens	83-91
10065757-6	1999	IL-4 and IFN-gamma suppressed PGE2 production by IL-1beta-stimulated PDL fibroblasts, but COX activity enhanced by IL-1beta treatment was significantly inhibited by IL-4, not by IFN-gamma.	Dinoprostone	30-34	interleukin 1 beta	Homo sapiens	49-57
10065757-9	1999	These data suggest that COX-2 is primarily responsible for PGE2 production by IL-1beta-stimulated human PDL fibroblasts and that IL-4 inhibited PGE2 production by IL-1beta-stimulated PDL fibroblasts through down-regulation of COX-2 expression, while IFN-gamma suppressed the PGE2 production with no effect on COX-2 expression.	Dinoprostone	59-63	interleukin 1 beta	Homo sapiens	78-86
10065757-9	1999	These data suggest that COX-2 is primarily responsible for PGE2 production by IL-1beta-stimulated human PDL fibroblasts and that IL-4 inhibited PGE2 production by IL-1beta-stimulated PDL fibroblasts through down-regulation of COX-2 expression, while IFN-gamma suppressed the PGE2 production with no effect on COX-2 expression.	Dinoprostone	144-148	interleukin 1 beta	Homo sapiens	163-171
10065757-9	1999	These data suggest that COX-2 is primarily responsible for PGE2 production by IL-1beta-stimulated human PDL fibroblasts and that IL-4 inhibited PGE2 production by IL-1beta-stimulated PDL fibroblasts through down-regulation of COX-2 expression, while IFN-gamma suppressed the PGE2 production with no effect on COX-2 expression.	Dinoprostone	144-148	interleukin 1 beta	Homo sapiens	163-171
10636471-0	1999	Inhibition of the NGF and IL-1beta-induced expression of Alzheimer"s amyloid precursor protein by antisense oligonucleotides.	Oligonucleotides	108-124	interleukin 1 beta	Homo sapiens	26-34
9950608-9	1999	RESULTS: TNF-alpha, IL-1beta, and TII but not IFN-gamma alone caused degradation of I kappaB, Rel A nuclear translocation, and increased NF-kappaB DNA binding activity, effects that were blocked by pretreatment with MG-132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	216-222	interleukin 1 beta	Homo sapiens	20-28
10204468-7	1999	In addition, 4-methacryloxyethyl trimelliate anhydride induced secretion of IL-1 beta, but not TNF-alpha, without the LPS challenge.	4-methacryloxyethyl trimelliate anhydride	13-54	interleukin 1 beta	Homo sapiens	76-85
10636471-5	1999	In this study, we investigated the effects of antisense oligonucleotide (AO) on the overexpression of APP induced by IL-1beta and NGF.	Oligonucleotides	56-71	interleukin 1 beta	Homo sapiens	117-125
10636471-5	1999	In this study, we investigated the effects of antisense oligonucleotide (AO) on the overexpression of APP induced by IL-1beta and NGF.	Oligonucleotides, Antisense	73-75	interleukin 1 beta	Homo sapiens	117-125
10090397-3	1999	Using a three-cytokine mixture (TNF-alpha, IL-1beta, and IFN-gamma) that could maximally induce both iNOS and sPLA2, the increase in these mRNA species reached a maximum by 4-8 h, followed by a decline up to 48 h. L-N6-(1-Iminoethyl)lysine acetate (L-NIL) inhibited cytokine-induced NO production with IC50 of 25 microM, but this compound did not affect iNOS mRNA.	L-NIL	249-254	interleukin 1 beta	Homo sapiens	43-51
10207838-0	1999	Prostaglandin E2 and I2 regulate intercellular adhesion molecule-1 expression in interleukin-1 beta-stimulated human gingival fibroblasts.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	81-99
10207838-6	1999	Exogenous PGE2 and carbacyclin (a stable derivative of PGI2) in the presence of indomethacin dose-dependently suppressed ICAM-1 expression in IL-1 beta-challenged HGF.	carboprostacyclin	19-30	interleukin 1 beta	Homo sapiens	142-151
10207838-6	1999	Exogenous PGE2 and carbacyclin (a stable derivative of PGI2) in the presence of indomethacin dose-dependently suppressed ICAM-1 expression in IL-1 beta-challenged HGF.	Epoprostenol	55-59	interleukin 1 beta	Homo sapiens	142-151
10207838-1	1999	The present study investigated the effect of prostaglandin (PG) E2 and PGI2 on intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1 beta (IL-1 beta)-stimulated human gingival fibroblasts (HGF).	Dinoprostone	45-66	interleukin 1 beta	Homo sapiens	136-154
10207838-6	1999	Exogenous PGE2 and carbacyclin (a stable derivative of PGI2) in the presence of indomethacin dose-dependently suppressed ICAM-1 expression in IL-1 beta-challenged HGF.	Indomethacin	80-92	interleukin 1 beta	Homo sapiens	142-151
10207838-1	1999	The present study investigated the effect of prostaglandin (PG) E2 and PGI2 on intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1 beta (IL-1 beta)-stimulated human gingival fibroblasts (HGF).	Dinoprostone	45-66	interleukin 1 beta	Homo sapiens	156-165
10207838-9	1999	These results suggest that PGE2 and PGI2 downregulate ICAM-1 expression in IL-1 beta-stimulated HGF through a cAMP-dependent mechanism and that intracellular cAMP elevation in HGF may control inflammatory and immune responses in periodontal disease.	Dinoprostone	27-31	interleukin 1 beta	Homo sapiens	75-84
10207838-9	1999	These results suggest that PGE2 and PGI2 downregulate ICAM-1 expression in IL-1 beta-stimulated HGF through a cAMP-dependent mechanism and that intracellular cAMP elevation in HGF may control inflammatory and immune responses in periodontal disease.	Epoprostenol	36-40	interleukin 1 beta	Homo sapiens	75-84
10207838-1	1999	The present study investigated the effect of prostaglandin (PG) E2 and PGI2 on intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1 beta (IL-1 beta)-stimulated human gingival fibroblasts (HGF).	Epoprostenol	71-75	interleukin 1 beta	Homo sapiens	136-154
10207838-9	1999	These results suggest that PGE2 and PGI2 downregulate ICAM-1 expression in IL-1 beta-stimulated HGF through a cAMP-dependent mechanism and that intracellular cAMP elevation in HGF may control inflammatory and immune responses in periodontal disease.	Cyclic AMP	110-114	interleukin 1 beta	Homo sapiens	75-84
10207838-1	1999	The present study investigated the effect of prostaglandin (PG) E2 and PGI2 on intercellular adhesion molecule-1 (ICAM-1) expression in interleukin-1 beta (IL-1 beta)-stimulated human gingival fibroblasts (HGF).	Epoprostenol	71-75	interleukin 1 beta	Homo sapiens	156-165
10207838-2	1999	IL-1 beta potently induced ICAM-1 expression in HGF and indomethacin, a cyclooxygenase inhibitor, enhanced ICAM-1 expression in the cells.	Indomethacin	56-68	interleukin 1 beta	Homo sapiens	0-9
10207838-3	1999	These data showed that endogenous PGs generated by HGF stimulated with IL-1 beta downregulated ICAM-1 expression.	Phosphatidylglycerols	34-37	interleukin 1 beta	Homo sapiens	71-80
10207838-4	1999	IL-1 beta significantly increased the levels of PGE2 and, to a lesser extent, those of 6-keto-PGF1 alpha (a stable metabolite of PGI2) in the culture media of HGF.	Dinoprostone	48-52	interleukin 1 beta	Homo sapiens	0-9
10207838-4	1999	IL-1 beta significantly increased the levels of PGE2 and, to a lesser extent, those of 6-keto-PGF1 alpha (a stable metabolite of PGI2) in the culture media of HGF.	6-Ketoprostaglandin F1 alpha	87-104	interleukin 1 beta	Homo sapiens	0-9
10207838-4	1999	IL-1 beta significantly increased the levels of PGE2 and, to a lesser extent, those of 6-keto-PGF1 alpha (a stable metabolite of PGI2) in the culture media of HGF.	Epoprostenol	129-133	interleukin 1 beta	Homo sapiens	0-9
10207838-5	1999	Indomethacin completely inhibited the production of PGE2 and 6-keto-PGF1 alpha in IL-1 beta-stimulated HGF.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	82-91
10207838-5	1999	Indomethacin completely inhibited the production of PGE2 and 6-keto-PGF1 alpha in IL-1 beta-stimulated HGF.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	82-91
10207838-5	1999	Indomethacin completely inhibited the production of PGE2 and 6-keto-PGF1 alpha in IL-1 beta-stimulated HGF.	6-keto-pgf1	61-72	interleukin 1 beta	Homo sapiens	82-91
10207838-6	1999	Exogenous PGE2 and carbacyclin (a stable derivative of PGI2) in the presence of indomethacin dose-dependently suppressed ICAM-1 expression in IL-1 beta-challenged HGF.	Dinoprostone	10-14	interleukin 1 beta	Homo sapiens	142-151
11819386-0	1999	Expression of IL 1betaconverting enzyme in 5-FU induced apoptosis in esophageal carcinoma cells.	Fluorouracil	43-47	interleukin 1 beta	Homo sapiens	14-18
9972827-7	1999	Following treatment with interleukin-1beta (IL-1beta), human astrocytes demonstrated increased message and protein expression for MIP-1alpha, while other immune modulators such as interferon-gamma (IFN)-gamma, tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), lipopolysaccharide, or phorbol ester (a protein kinase C activator) did not induce MIP-1alpha expression in human astrocytes.	Phorbol Esters	333-346	interleukin 1 beta	Homo sapiens	25-42
9972827-7	1999	Following treatment with interleukin-1beta (IL-1beta), human astrocytes demonstrated increased message and protein expression for MIP-1alpha, while other immune modulators such as interferon-gamma (IFN)-gamma, tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), lipopolysaccharide, or phorbol ester (a protein kinase C activator) did not induce MIP-1alpha expression in human astrocytes.	Phorbol Esters	333-346	interleukin 1 beta	Homo sapiens	44-52
9986920-0	1999	Acute intrahippocampal injection of human interleukin-1beta stimulates the anterior pituitary POMC transcription and increases plasma levels of ACTH and corticosterone in the male rat.	Corticosterone	153-167	interleukin 1 beta	Homo sapiens	42-59
9986920-5	1999	Following this, animals were sacrificed at times 20, 45 and 90 min postinjection and a kinetic analysis of hIL-1beta action on plasma ACTH and corticosterone (CORT) concentrations and nuclear processing of the anterior pituitary (AP) proopiomelanocortin (POMC) was conducted.	Corticosterone	143-157	interleukin 1 beta	Homo sapiens	107-116
9986920-5	1999	Following this, animals were sacrificed at times 20, 45 and 90 min postinjection and a kinetic analysis of hIL-1beta action on plasma ACTH and corticosterone (CORT) concentrations and nuclear processing of the anterior pituitary (AP) proopiomelanocortin (POMC) was conducted.	Corticosterone	159-163	interleukin 1 beta	Homo sapiens	107-116
10442175-1	1999	Systemic interleukin IL-1 beta, TNF alpha, and IL-2 profoundly influenced central monoamine activity, as well as behavioral outputs.	monoamine	82-91	interleukin 1 beta	Homo sapiens	21-30
9874779-1	1999	Water in the hydrophobic cavity of human interleukin 1beta, which was detected by NMR spectroscopy but was invisible by high resolution x-ray crystallography, has been mapped quantitatively by measurement and phasing of all of the low resolution x-ray diffraction data from a single crystal.	Water	0-5	interleukin 1 beta	Homo sapiens	41-58
9886915-2	1999	The effect of IL-1beta was blocked by bisindolylmaleimide I, an inhibitor of PKC, and by the Ca2+ channel blockers nifedipine and verapamil.	bisindolylmaleimide I	38-59	interleukin 1 beta	Homo sapiens	14-22
9886915-2	1999	The effect of IL-1beta was blocked by bisindolylmaleimide I, an inhibitor of PKC, and by the Ca2+ channel blockers nifedipine and verapamil.	Nifedipine	115-125	interleukin 1 beta	Homo sapiens	14-22
9886915-2	1999	The effect of IL-1beta was blocked by bisindolylmaleimide I, an inhibitor of PKC, and by the Ca2+ channel blockers nifedipine and verapamil.	Verapamil	130-139	interleukin 1 beta	Homo sapiens	14-22
9886915-4	1999	Simultaneous application of phorbol ester and Ca2+ ionophore in the absence of IL-1beta mimicked the depolarization caused by IL-1beta.	Phorbol Esters	28-41	interleukin 1 beta	Homo sapiens	126-134
9887205-4	1999	TNF-alpha, IL-1beta, TNF-alpha + IL-1beta, and each of 5 sera from patients with acute septic shock caused depression of both maximum extent and peak velocity of cardiac myocyte shortening and an increase in intracellular cGMP concentration during 30 min of exposure (minimum P &lt; 0.01).	Cyclic GMP	222-226	interleukin 1 beta	Homo sapiens	11-19
9887205-7	1999	Exposure of myocytes to TNF-alpha, IL-1beta, or TNF-alpha + IL-1beta produced a concentration-dependent increase in intracellular cGMP that paralleled the depression of cardiac myocyte contractility (minimum P &lt; 0.001).	Cyclic GMP	130-134	interleukin 1 beta	Homo sapiens	35-43
9887205-4	1999	TNF-alpha, IL-1beta, TNF-alpha + IL-1beta, and each of 5 sera from patients with acute septic shock caused depression of both maximum extent and peak velocity of cardiac myocyte shortening and an increase in intracellular cGMP concentration during 30 min of exposure (minimum P &lt; 0.01).	Cyclic GMP	222-226	interleukin 1 beta	Homo sapiens	33-41
9887205-7	1999	Exposure of myocytes to TNF-alpha, IL-1beta, or TNF-alpha + IL-1beta produced a concentration-dependent increase in intracellular cGMP that paralleled the depression of cardiac myocyte contractility (minimum P &lt; 0.001).	Cyclic GMP	130-134	interleukin 1 beta	Homo sapiens	60-68
10470256-8	1999	These observations suggest that the apparent inhibitory effect of LT on the IL-1-induced expression of cytokines may not be through its direct action on the NF-kappa B transactivation.	Leu-Thr	66-68	interleukin 1 beta	Homo sapiens	76-80
9918155-9	1999	RESULTS: Carprofen significantly decreased PGE2 production by unstimulated chondrocytes and antagonized an IL-1-induced increase in PGE2 production.	carprofen	9-18	interleukin 1 beta	Homo sapiens	107-111
9918155-9	1999	RESULTS: Carprofen significantly decreased PGE2 production by unstimulated chondrocytes and antagonized an IL-1-induced increase in PGE2 production.	Dinoprostone	132-136	interleukin 1 beta	Homo sapiens	107-111
9918155-15	1999	Carprofen also inhibited PGE2 production by unstimulated and IL-1-stimulated chondrocytes.	carprofen	0-9	interleukin 1 beta	Homo sapiens	61-65
9918155-15	1999	Carprofen also inhibited PGE2 production by unstimulated and IL-1-stimulated chondrocytes.	Dinoprostone	25-29	interleukin 1 beta	Homo sapiens	61-65
10524499-7	1999	LPS-stimulated IL-1ra release was normal and the IL-1ra/IL-1beta ratio was therefore increased (P &lt; 0.05) and correlated inversely to prednisolone dosage (P = 0.009).	Prednisolone	137-149	interleukin 1 beta	Homo sapiens	56-64
11056661-18	1999	The production of PGE(2) by RSFs was unaffected by 1alpha,25(OH)(2)D(3) addition, but when added concomitantly with IL-1beta the expected IL-1beta-stimulated increase was reduced to almost basal levels.	Prostaglandins E	18-21	interleukin 1 beta	Homo sapiens	116-124
11056661-18	1999	The production of PGE(2) by RSFs was unaffected by 1alpha,25(OH)(2)D(3) addition, but when added concomitantly with IL-1beta the expected IL-1beta-stimulated increase was reduced to almost basal levels.	Prostaglandins E	18-21	interleukin 1 beta	Homo sapiens	138-146
9893189-3	1999	OBJECTIVES: We conducted a double-blind, placebo-controlled trial of 4 weeks of intranasal fluticasone propionate or matching placebo to assess their effectiveness in reducing NP inflammatory cells, expression of endothelial vascular cell adhesion molecule (VCAM)-1 and P-selectin, and expression of cytokines involved in induction of a group of adhesion molecules (ie, IL-4, IL-13, TNF-alpha, and IL-1beta).	Fluticasone	91-113	interleukin 1 beta	Homo sapiens	398-406
11056661-18	1999	The production of PGE(2) by RSFs was unaffected by 1alpha,25(OH)(2)D(3) addition, but when added concomitantly with IL-1beta the expected IL-1beta-stimulated increase was reduced to almost basal levels.	rsfs	28-32	interleukin 1 beta	Homo sapiens	138-146
11056661-19	1999	In contrast, IL-1beta stimulation of PGE(2) in HACs was not affected by the simultaneous addition of 1alpha,25(OH)(2)D(3)(Table 2).	Prostaglandins E	37-40	interleukin 1 beta	Homo sapiens	13-21
11056661-30	1999	The 1alpha,25(OH)2D3 had little effect on basal PGE2 production by RSF, but the enhanced PGE2 production observed following IL-1beta stimulation of these cells was markedly suppressed by the concomitant addition of 1alpha,25(OH)2D3.	Dinoprostone	89-93	interleukin 1 beta	Homo sapiens	124-132
11056661-31	1999	As with MMP production, there are disparate effects of 1alpha,25(OH)2D3 on IL-1beta stimulated PGE2 production by the two cell types; 1alpha,25(OH)2D3 added concomitantly with IL-1beta had no effect on PGE2 production by HACs.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	75-83
10026370-1	1999	The effects of dexamethasone on the production of interleukin (IL) 1beta, IL-6, and tumor necrosis factor alpha were studied in preterm newborns, term infants, and adults.	Dexamethasone	15-28	interleukin 1 beta	Homo sapiens	50-72
10026370-5	1999	Spontaneous secretion of IL-1beta or IL-6 by MC of preterm neonates was less inhibited by dexamethasone as compared with cells from adults.	Methylcholanthrene	45-47	interleukin 1 beta	Homo sapiens	25-33
10026370-5	1999	Spontaneous secretion of IL-1beta or IL-6 by MC of preterm neonates was less inhibited by dexamethasone as compared with cells from adults.	Dexamethasone	90-103	interleukin 1 beta	Homo sapiens	25-33
9892219-5	1999	The combination of interleukin-1beta (IL-1beta) plus interferon-gamma (IFN-gamma) increased nitric oxide production 12-fold while stimulating mRNA expression of inducible nitric oxide synthase (iNOS).	Nitric Oxide	92-104	interleukin 1 beta	Homo sapiens	19-36
9892219-5	1999	The combination of interleukin-1beta (IL-1beta) plus interferon-gamma (IFN-gamma) increased nitric oxide production 12-fold while stimulating mRNA expression of inducible nitric oxide synthase (iNOS).	Nitric Oxide	92-104	interleukin 1 beta	Homo sapiens	38-46
9931118-4	1999	IL-1beta-stimulated hBNP luciferase activity was eliminated by pretreatment with the transcription inhibitor actinomycin D.	Dactinomycin	109-122	interleukin 1 beta	Homo sapiens	0-8
9931118-5	1999	Both the p38 kinase inhibitor SB205380 (SB) and cotransfection of a dominant-negative mutant of p38 kinase reduced IL-1beta stimulation of the hBNP promoter.	sb205380	30-38	interleukin 1 beta	Homo sapiens	115-123
12793958-9	1999	CONCLUSIONS: MTX in combination with prednizone decreases blood levels of IL-1 beta and IL-6 and inhibits the intensity of free radical- mediated processes in RA subjects.	prednizone	37-47	interleukin 1 beta	Homo sapiens	74-83
9887205-8	1999	In addition, TNF-alpha, IL-1beta, TNF-alpha + IL-1beta, or HSS application to cardiac myocytes resulted in increased NO gas generation, which was inhibited by L-NMA (minimum P &lt; 0.01).	l-nma	159-164	interleukin 1 beta	Homo sapiens	24-32
9887205-8	1999	In addition, TNF-alpha, IL-1beta, TNF-alpha + IL-1beta, or HSS application to cardiac myocytes resulted in increased NO gas generation, which was inhibited by L-NMA (minimum P &lt; 0.01).	l-nma	159-164	interleukin 1 beta	Homo sapiens	46-54
9887205-10	1999	These data suggest that the sequential generation of NO by a constitutive NOS and cGMP by guanylate cyclase represents an important mechanism of cardiac myocyte depression by TNF-alpha, IL-1beta, TNF-alpha + IL-1beta, and the myocardial depressant substance(s) of septic shock.	Cyclic GMP	82-86	interleukin 1 beta	Homo sapiens	186-194
9887205-10	1999	These data suggest that the sequential generation of NO by a constitutive NOS and cGMP by guanylate cyclase represents an important mechanism of cardiac myocyte depression by TNF-alpha, IL-1beta, TNF-alpha + IL-1beta, and the myocardial depressant substance(s) of septic shock.	Cyclic GMP	82-86	interleukin 1 beta	Homo sapiens	208-216
10437301-7	1999	After interleukin-1 beta stimulation chondrocytes produced great quantities of nitrosothiols and nitrite.	S-Nitrosothiols	79-92	interleukin 1 beta	Homo sapiens	6-24
10437301-7	1999	After interleukin-1 beta stimulation chondrocytes produced great quantities of nitrosothiols and nitrite.	Nitrites	97-104	interleukin 1 beta	Homo sapiens	6-24
10437301-9	1999	In conclusion, chondrocytes produce high quantities of nitrosothiols after IL-1 beta stimulation and this effect is inhibited by rhein.	S-Nitrosothiols	55-68	interleukin 1 beta	Homo sapiens	75-84
12793958-0	1999	Combination of methotrexate and prednizone decreases circulating concentrations of interleukin 1 beta and Interleukin 6 in patients with rheumatoid arthritis.	Methotrexate	15-27	interleukin 1 beta	Homo sapiens	83-101
12793958-0	1999	Combination of methotrexate and prednizone decreases circulating concentrations of interleukin 1 beta and Interleukin 6 in patients with rheumatoid arthritis.	prednizone	32-42	interleukin 1 beta	Homo sapiens	83-101
12793958-7	1999	MTX in combination with prednizone improved patient clinical status that was accompanied by 1.96-, 1.25-, and 1.35-fold decrease in IL-1 beta, IL-6 and TBARs after 6 month treatment (p&lt;0.001), respectively.	Methotrexate	0-3	interleukin 1 beta	Homo sapiens	132-141
12793958-7	1999	MTX in combination with prednizone improved patient clinical status that was accompanied by 1.96-, 1.25-, and 1.35-fold decrease in IL-1 beta, IL-6 and TBARs after 6 month treatment (p&lt;0.001), respectively.	prednizone	24-34	interleukin 1 beta	Homo sapiens	132-141
12793958-9	1999	CONCLUSIONS: MTX in combination with prednizone decreases blood levels of IL-1 beta and IL-6 and inhibits the intensity of free radical- mediated processes in RA subjects.	Methotrexate	13-16	interleukin 1 beta	Homo sapiens	74-83
10421684-10	1999	PE particles stimulated the expression of IL-1beta, IL-6, and TNF-alpha in the BHC model.	pe	0-2	interleukin 1 beta	Homo sapiens	42-50
9930944-3	1999	Methylprednisolone (10 microg/ml) inhibited the release of IL-1beta and TNFalpha, but had no effect on superoxide generation.	Methylprednisolone	0-18	interleukin 1 beta	Homo sapiens	59-67
10065947-0	1999	Signal transduction pathways involved in the synergistic stimulation of prostaglandin production by interleukin-1beta and tumor necrosis factor alpha in human gingival fibroblasts.	Prostaglandins	72-85	interleukin 1 beta	Homo sapiens	100-149
10065947-2	1999	In this study, the effects and interactions between IL-1beta and TNFalpha on prostaglandin production and its regulation were investigated.	Prostaglandins	77-90	interleukin 1 beta	Homo sapiens	52-60
10065947-3	1999	The cytokines IL-1beta and TNFalpha stimulated prostaglandin E2 (PGE2) and prostacyclin (PGI2) production in gingival fibroblasts.	Dinoprostone	47-63	interleukin 1 beta	Homo sapiens	14-22
10065947-3	1999	The cytokines IL-1beta and TNFalpha stimulated prostaglandin E2 (PGE2) and prostacyclin (PGI2) production in gingival fibroblasts.	Dinoprostone	65-69	interleukin 1 beta	Homo sapiens	14-22
10065947-3	1999	The cytokines IL-1beta and TNFalpha stimulated prostaglandin E2 (PGE2) and prostacyclin (PGI2) production in gingival fibroblasts.	Epoprostenol	75-87	interleukin 1 beta	Homo sapiens	14-22
10065947-3	1999	The cytokines IL-1beta and TNFalpha stimulated prostaglandin E2 (PGE2) and prostacyclin (PGI2) production in gingival fibroblasts.	Epoprostenol	89-93	interleukin 1 beta	Homo sapiens	14-22
10065947-4	1999	Simultaneous treatment of the cells with IL-1beta and TNFalpha resulted in a synergistic stimulation of PGE2 and PGI2 formation.	Dinoprostone	104-108	interleukin 1 beta	Homo sapiens	41-49
10065947-4	1999	Simultaneous treatment of the cells with IL-1beta and TNFalpha resulted in a synergistic stimulation of PGE2 and PGI2 formation.	Epoprostenol	113-117	interleukin 1 beta	Homo sapiens	41-49
10065947-5	1999	IL-1beta and, to a lesser extent, TNFalpha stimulated the release of 3H-arachidonic acid (3H-AA), and simultaneous addition of IL-1beta and TNFalpha further increased the release of 3H-AA from pre-labeled gingival fibroblasts.	3h-arachidonic acid	69-88	interleukin 1 beta	Homo sapiens	0-8
10065947-5	1999	IL-1beta and, to a lesser extent, TNFalpha stimulated the release of 3H-arachidonic acid (3H-AA), and simultaneous addition of IL-1beta and TNFalpha further increased the release of 3H-AA from pre-labeled gingival fibroblasts.	3h-aa	90-95	interleukin 1 beta	Homo sapiens	0-8
10065947-5	1999	IL-1beta and, to a lesser extent, TNFalpha stimulated the release of 3H-arachidonic acid (3H-AA), and simultaneous addition of IL-1beta and TNFalpha further increased the release of 3H-AA from pre-labeled gingival fibroblasts.	3h-aa	182-187	interleukin 1 beta	Homo sapiens	0-8
10065947-5	1999	IL-1beta and, to a lesser extent, TNFalpha stimulated the release of 3H-arachidonic acid (3H-AA), and simultaneous addition of IL-1beta and TNFalpha further increased the release of 3H-AA from pre-labeled gingival fibroblasts.	3h-aa	182-187	interleukin 1 beta	Homo sapiens	127-135
10065947-7	1999	Simultaneous addition of IL-1beta and TNFalpha synergistically enhanced COX-2 mRNA levels, accompanied by a corresponding stimulation of PGE2 synthesis.	Dinoprostone	137-141	interleukin 1 beta	Homo sapiens	25-33
10065947-9	1999	PMA, known to activate protein kinase C (PKC), enhanced the stimulatory effect of IL-1beta, TNFalpha, and the combination on COX-2 mRNA levels accompanied by a corresponding increase in PGE2 production.	Dinoprostone	186-190	interleukin 1 beta	Homo sapiens	82-90
10065947-10	1999	The phospholipase A2 (PLA2) inhibitor, BPB, and the PKC inhibitor, BIS, reduced PGE2 production, whereas dexamethasone, indomethacin, and NS-398 completely abolished PGE2 production induced by IL-1beta, TNFalpha, and the combination.	Dexamethasone	105-118	interleukin 1 beta	Homo sapiens	193-201
10065947-10	1999	The phospholipase A2 (PLA2) inhibitor, BPB, and the PKC inhibitor, BIS, reduced PGE2 production, whereas dexamethasone, indomethacin, and NS-398 completely abolished PGE2 production induced by IL-1beta, TNFalpha, and the combination.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	138-144	interleukin 1 beta	Homo sapiens	193-201
10065947-11	1999	The study indicates that the synergistic stimulation of prostaglandin production by IL-1beta, and TNFalpha is mediated partly at the level of COX-2 and partly at the level of PLA2 and that PKC is involved in the signal transduction of the synergy between the two cytokines.	Prostaglandins	56-69	interleukin 1 beta	Homo sapiens	84-92
9930944-4	1999	Both pentoxifylline (66 microg/ml) and cyclosporin A (300 ng/ml) slightly inhibited TNFalpha release without affecting IL-1beta or superoxide generation.	Cyclosporine	39-52	interleukin 1 beta	Homo sapiens	119-127
9930944-5	1999	Nicotinamide (0.25 mM) did not interfere with the generation TNFalpha or superoxide and only slightly inhibited IL-1beta production.	Niacinamide	0-12	interleukin 1 beta	Homo sapiens	112-120
9930944-6	1999	A combination of methylprednisolone, pentoxifylline, cyclosporin A, and nicotinamide (concentrations for each substance as described above) inhibited TNFalpha generation by 74+/-6% (mean value+/-SEM, mononuclear blood cells from seven diabetic patients) without affecting IL-1beta or superoxide generation.	Methylprednisolone	17-35	interleukin 1 beta	Homo sapiens	272-280
9930944-6	1999	A combination of methylprednisolone, pentoxifylline, cyclosporin A, and nicotinamide (concentrations for each substance as described above) inhibited TNFalpha generation by 74+/-6% (mean value+/-SEM, mononuclear blood cells from seven diabetic patients) without affecting IL-1beta or superoxide generation.	Pentoxifylline	37-51	interleukin 1 beta	Homo sapiens	272-280
9930944-6	1999	A combination of methylprednisolone, pentoxifylline, cyclosporin A, and nicotinamide (concentrations for each substance as described above) inhibited TNFalpha generation by 74+/-6% (mean value+/-SEM, mononuclear blood cells from seven diabetic patients) without affecting IL-1beta or superoxide generation.	Cyclosporine	53-66	interleukin 1 beta	Homo sapiens	272-280
9930944-6	1999	A combination of methylprednisolone, pentoxifylline, cyclosporin A, and nicotinamide (concentrations for each substance as described above) inhibited TNFalpha generation by 74+/-6% (mean value+/-SEM, mononuclear blood cells from seven diabetic patients) without affecting IL-1beta or superoxide generation.	Niacinamide	72-84	interleukin 1 beta	Homo sapiens	272-280
10343934-4	1999	Rising concentrations of hyaluronan at this time have been considered as potent inducers of IL-1 beta and TNF-alpha synthesis by various leukocyte populations.	Hyaluronic Acid	25-35	interleukin 1 beta	Homo sapiens	92-101
10659589-9	1999	The data suggest that IL-1 beta presynaptically depressed the EPSP by reducing the release of acetylcholine (ACh) from the pelvic nerve terminals.	Acetylcholine	94-107	interleukin 1 beta	Homo sapiens	22-31
10659589-9	1999	The data suggest that IL-1 beta presynaptically depressed the EPSP by reducing the release of acetylcholine (ACh) from the pelvic nerve terminals.	Acetylcholine	109-112	interleukin 1 beta	Homo sapiens	22-31
10597884-9	1999	More lipid peroxides appeared when endothelial cells were stimulated by IL-1beta or TNFalpha and the inhibitory effect of ibuprofen in this case was more pronounced.	Ibuprofen	122-131	interleukin 1 beta	Homo sapiens	72-80
10597884-10	1999	Ibuprofen (1 mM, 100 microg/ml LDL) reduced the amount of lipid peroxides formed during incubation of LDL with IL-1beta-stimulated HUVEC by 43%.	Ibuprofen	0-9	interleukin 1 beta	Homo sapiens	111-119
10597884-10	1999	Ibuprofen (1 mM, 100 microg/ml LDL) reduced the amount of lipid peroxides formed during incubation of LDL with IL-1beta-stimulated HUVEC by 43%.	Lipid Peroxides	58-73	interleukin 1 beta	Homo sapiens	111-119
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	31-35	interleukin 1 beta	Homo sapiens	116-124
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	31-35	interleukin 1 beta	Homo sapiens	208-216
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	170-174	interleukin 1 beta	Homo sapiens	208-216
10815617-14	1999	The results suggested that (i) PGE2 can initiate negative feedback regulation in the induction of COX-2 elicited by IL-1beta in endothelial cells, (ii) the inhibition of PGE2 on COX-2 protein and activity in IL-1beta treated HUVEC is mediated by cAMP and (iii) the therapeutic use of PGE2 in the condition which COX-2 has been involved may have different roles.	Dinoprostone	170-174	interleukin 1 beta	Homo sapiens	208-216
18475905-5	1999	In a macrophage line, THP-1, which synthesizes IL-1beta in response to mitogen, we have shown that dicyanogold inhibits the binding of a second transcription factor, CREB to DNA.	dicyanogold	99-110	interleukin 1 beta	Homo sapiens	47-55
18475905-6	1999	Incubation of THP-1 cells with dicyanogold inhibits the production of IL-1beta mRNA.	dicyanogold	31-42	interleukin 1 beta	Homo sapiens	70-78
9918236-5	1999	RESULTS: Spontaneous tumor necrosis factor-alpha and interleukin 1beta secretion by primary synovial cells of patients with RA was reduced by actarit at therapeutic concentrations (10(-5)-10(-6) M).	4-(acetylamino)benzeneacetic acid	142-149	interleukin 1 beta	Homo sapiens	53-70
12840854-0	1999	Effect of interleukin-1 beta on the elevation of cytoplasmic free calcium of the cultured hippocampal neurons induced by L-glutamate.	Calcium	66-73	interleukin 1 beta	Homo sapiens	10-28
12840854-0	1999	Effect of interleukin-1 beta on the elevation of cytoplasmic free calcium of the cultured hippocampal neurons induced by L-glutamate.	Glutamic Acid	121-132	interleukin 1 beta	Homo sapiens	10-28
12840854-3	1999	MK-801 inhibited the effect of Glu on [Ca2+]i, and also inhibited the effect of IL-1 beta on [Ca2+]i induced by Glu, while verapamil did not influence the effect of Glu or IL-1 beta.	Dizocilpine Maleate	0-6	interleukin 1 beta	Homo sapiens	80-89
12840854-3	1999	MK-801 inhibited the effect of Glu on [Ca2+]i, and also inhibited the effect of IL-1 beta on [Ca2+]i induced by Glu, while verapamil did not influence the effect of Glu or IL-1 beta.	Dizocilpine Maleate	0-6	interleukin 1 beta	Homo sapiens	172-181
12840854-3	1999	MK-801 inhibited the effect of Glu on [Ca2+]i, and also inhibited the effect of IL-1 beta on [Ca2+]i induced by Glu, while verapamil did not influence the effect of Glu or IL-1 beta.	Glutamic Acid	112-115	interleukin 1 beta	Homo sapiens	80-89
12840854-3	1999	MK-801 inhibited the effect of Glu on [Ca2+]i, and also inhibited the effect of IL-1 beta on [Ca2+]i induced by Glu, while verapamil did not influence the effect of Glu or IL-1 beta.	Glutamic Acid	112-115	interleukin 1 beta	Homo sapiens	80-89
12840854-4	1999	It is concluded that IL-1 beta, as a neuromodulator, can facilitate the activation of NMDA receptor by Glu, induce the increase of intracellular calcium, which enhances the excitement of neuron.	Glutamic Acid	103-106	interleukin 1 beta	Homo sapiens	21-30
12840854-4	1999	It is concluded that IL-1 beta, as a neuromodulator, can facilitate the activation of NMDA receptor by Glu, induce the increase of intracellular calcium, which enhances the excitement of neuron.	Calcium	145-152	interleukin 1 beta	Homo sapiens	21-30
10815617-0	1999	The induction of cyclooxygenase-2 in IL-1beta-treated endothelial cells is inhibited by prostaglandin E2 through cAMP.	Dinoprostone	88-104	interleukin 1 beta	Homo sapiens	37-45
10815617-0	1999	The induction of cyclooxygenase-2 in IL-1beta-treated endothelial cells is inhibited by prostaglandin E2 through cAMP.	Cyclic AMP	113-117	interleukin 1 beta	Homo sapiens	37-45
10815617-10	1999	Interestingly, PGE2 (3 microM for 24h) can inhibit COX-2 protein, but not COX-1 protein, expressed in HUVEC treated with IL-1beta.	Dinoprostone	15-19	interleukin 1 beta	Homo sapiens	121-129
10815617-12	1999	The increased COX activity in HUVEC treated with IL-1beta was also inhibited by PGE2 (0.03, 0.3 and 3 microM for 24h) in a dose-dependent manner.	Dinoprostone	80-84	interleukin 1 beta	Homo sapiens	49-57
10815617-13	1999	Similarly, forskolin (10, 50 or 100 microM) can also reverse the inhibition of PGE2 on increased COX activity in IL-1beta treated HUVEC.	Colforsin	11-20	interleukin 1 beta	Homo sapiens	113-121
10815617-13	1999	Similarly, forskolin (10, 50 or 100 microM) can also reverse the inhibition of PGE2 on increased COX activity in IL-1beta treated HUVEC.	Dinoprostone	79-83	interleukin 1 beta	Homo sapiens	113-121
10613507-4	1999	We found that bilateral central amygdala lesions significantly reduced interleukin-1beta-induced c-fos expression in cells of the ventromedial and ventrolateral subdivisions of the bed nucleus of the stria terminalis and brainstem catecholamine cell groups of the nucleus tractus solitarius (A2 noradrenergic cells) and ventrolateral medulla (A1 noradrenergic and C1 adrenergic cells).	Catecholamines	231-244	interleukin 1 beta	Homo sapiens	71-88
9916962-8	1999	EP1 receptor levels also increased approximately fourfold in response to IL-1beta incubation even in the presence of high agonist (PGE2) concentrations (P &lt; .01).	Dinoprostone	131-135	interleukin 1 beta	Homo sapiens	73-81
9916962-9	1999	CONCLUSION: The results of this study show that IL-1beta might be involved in infection-induced preterm labor by interfering with the normal regulation of EP1 receptor levels and with the promotion of increased PGE2 production in amnion tissue.	Dinoprostone	211-215	interleukin 1 beta	Homo sapiens	48-56
10201336-11	1999	However, a significant correlation was found between serum hyaluronan concentration and glomerular filtration rate (GFR) (r = -0.49, p&lt; 0.005); GFR also tended to be correlated with serum TNFalpha (r = -0.31, p = 0.058) but not with serum IL-1beta and serum CRP.	Hyaluronic Acid	59-69	interleukin 1 beta	Homo sapiens	242-250
10479931-7	1999	In patients with infiltrative tuberculosis, the production of TNF-alpha and IL-1 beta was directly related to the proportion of CD4+ and CDS8+ and that of IL-2 is associated with the proportion of CD25+ and CD20+ and with the count of lymphocytes.	cds8+	137-142	interleukin 1 beta	Homo sapiens	76-85
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	62-70
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 beta	Homo sapiens	62-70
10051376-6	1999	These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages.	Curcumin	24-32	interleukin 1 beta	Homo sapiens	109-117
10216428-4	1999	LPS (100 ng/ml, for 3 to 6 h) or IL-1 beta potentiated bradykinin and the tachykinin NK-1 selective receptor agonist [Sar9, Met-O2] SP -induced human isolated bronchi contraction in vitro (IL-1 beta 3 10(-10) M, at 37 degrees C for 1 to 3 h for bradykinin or at 21 degrees C for 15 h for [Sar9, Met-O2] SP in Krebs-Henseleit solution).	Oxygen	128-130	interleukin 1 beta	Homo sapiens	33-42
10464849-1	1999	The aim of this study was to investigate the effects of pentoxifylline (PTX) on the production of TNF-alpha, IL-1 beta, IL-6 and GM-CSF by lipopolysaccharide (LPS)-stimulated alveolar macrophages (AM).	Pentoxifylline	56-70	interleukin 1 beta	Homo sapiens	109-118
10464849-1	1999	The aim of this study was to investigate the effects of pentoxifylline (PTX) on the production of TNF-alpha, IL-1 beta, IL-6 and GM-CSF by lipopolysaccharide (LPS)-stimulated alveolar macrophages (AM).	Pentoxifylline	72-75	interleukin 1 beta	Homo sapiens	109-118
10216428-4	1999	LPS (100 ng/ml, for 3 to 6 h) or IL-1 beta potentiated bradykinin and the tachykinin NK-1 selective receptor agonist [Sar9, Met-O2] SP -induced human isolated bronchi contraction in vitro (IL-1 beta 3 10(-10) M, at 37 degrees C for 1 to 3 h for bradykinin or at 21 degrees C for 15 h for [Sar9, Met-O2] SP in Krebs-Henseleit solution).	TFF2 protein, human	132-134	interleukin 1 beta	Homo sapiens	33-42
10216428-4	1999	LPS (100 ng/ml, for 3 to 6 h) or IL-1 beta potentiated bradykinin and the tachykinin NK-1 selective receptor agonist [Sar9, Met-O2] SP -induced human isolated bronchi contraction in vitro (IL-1 beta 3 10(-10) M, at 37 degrees C for 1 to 3 h for bradykinin or at 21 degrees C for 15 h for [Sar9, Met-O2] SP in Krebs-Henseleit solution).	TFF2 protein, human	132-134	interleukin 1 beta	Homo sapiens	189-198
10216428-4	1999	LPS (100 ng/ml, for 3 to 6 h) or IL-1 beta potentiated bradykinin and the tachykinin NK-1 selective receptor agonist [Sar9, Met-O2] SP -induced human isolated bronchi contraction in vitro (IL-1 beta 3 10(-10) M, at 37 degrees C for 1 to 3 h for bradykinin or at 21 degrees C for 15 h for [Sar9, Met-O2] SP in Krebs-Henseleit solution).	met-o2	124-130	interleukin 1 beta	Homo sapiens	33-42
10216428-4	1999	LPS (100 ng/ml, for 3 to 6 h) or IL-1 beta potentiated bradykinin and the tachykinin NK-1 selective receptor agonist [Sar9, Met-O2] SP -induced human isolated bronchi contraction in vitro (IL-1 beta 3 10(-10) M, at 37 degrees C for 1 to 3 h for bradykinin or at 21 degrees C for 15 h for [Sar9, Met-O2] SP in Krebs-Henseleit solution).	TFF2 protein, human	303-305	interleukin 1 beta	Homo sapiens	33-42
10216428-4	1999	LPS (100 ng/ml, for 3 to 6 h) or IL-1 beta potentiated bradykinin and the tachykinin NK-1 selective receptor agonist [Sar9, Met-O2] SP -induced human isolated bronchi contraction in vitro (IL-1 beta 3 10(-10) M, at 37 degrees C for 1 to 3 h for bradykinin or at 21 degrees C for 15 h for [Sar9, Met-O2] SP in Krebs-Henseleit solution).	krebs	309-314	interleukin 1 beta	Homo sapiens	33-42
10216428-5	1999	As in control bronchi, the effects of bradykinin and of [Sar9, Met-O2] SP after interleukin 1 beta pre-treatment were abolished by indomethacin (10(-6) M), the thromboxane A2 receptor antagonist GR 32191 suggesting that prostanoids remain involved under these experimental conditions.	Indomethacin	131-143	interleukin 1 beta	Homo sapiens	80-98
10216428-7	1999	The cyclooxygenase 2 (cox 2) inhibitor GGP 28238 (10(-6) M) inhibited IL-1 beta-induced potentiation of [Sar9, Met-O2] SP but not of bradykinin effect.	met-o2	111-117	interleukin 1 beta	Homo sapiens	70-79
10216428-7	1999	The cyclooxygenase 2 (cox 2) inhibitor GGP 28238 (10(-6) M) inhibited IL-1 beta-induced potentiation of [Sar9, Met-O2] SP but not of bradykinin effect.	TFF2 protein, human	119-121	interleukin 1 beta	Homo sapiens	70-79
10216428-8	1999	Bradykinin and [Sar9, Met-O2] SP induced a release of TxB2, the stable metabolite of TxA2, in the organ bath and this release was increased by IL-1 beta pre-treatment.	met-o2] sp	22-32	interleukin 1 beta	Homo sapiens	143-152
9872417-0	1998	Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol.	7alpha-, 7beta-hydroxycholesterol	135-168	interleukin 1 beta	Homo sapiens	22-30
9889172-4	1998	In addition, the anti-inflammatory effects of the two terpenes on IL-1beta production were analysed.	Terpenes	54-62	interleukin 1 beta	Homo sapiens	66-74
9934491-2	1998	Truncated analogs of tripterine as cytokine (IL-1 alpha, IL-1 beta, TNF-alpha, IL-6, and IL-8) release inhibitors are discussed.	celastrol	21-31	interleukin 1 beta	Homo sapiens	57-66
9973188-2	1998	Gold sodium thiomalate (GSTM) impaired the ability of interleukin 1beta (IL-1beta)-stimulated human umbilical vein endothelial cells (HUVEC) to express E-selectin and to bind PMN but had no effect on the expression of intercellular adhesion molecule 1 (ICAM-1) or on hyperadhesivity of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated PMN.	Gold Sodium Thiomalate	0-22	interleukin 1 beta	Homo sapiens	54-71
9973188-2	1998	Gold sodium thiomalate (GSTM) impaired the ability of interleukin 1beta (IL-1beta)-stimulated human umbilical vein endothelial cells (HUVEC) to express E-selectin and to bind PMN but had no effect on the expression of intercellular adhesion molecule 1 (ICAM-1) or on hyperadhesivity of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated PMN.	Gold Sodium Thiomalate	0-22	interleukin 1 beta	Homo sapiens	73-81
9973188-2	1998	Gold sodium thiomalate (GSTM) impaired the ability of interleukin 1beta (IL-1beta)-stimulated human umbilical vein endothelial cells (HUVEC) to express E-selectin and to bind PMN but had no effect on the expression of intercellular adhesion molecule 1 (ICAM-1) or on hyperadhesivity of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated PMN.	Gold Sodium Thiomalate	24-28	interleukin 1 beta	Homo sapiens	54-71
9973188-2	1998	Gold sodium thiomalate (GSTM) impaired the ability of interleukin 1beta (IL-1beta)-stimulated human umbilical vein endothelial cells (HUVEC) to express E-selectin and to bind PMN but had no effect on the expression of intercellular adhesion molecule 1 (ICAM-1) or on hyperadhesivity of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated PMN.	Gold Sodium Thiomalate	24-28	interleukin 1 beta	Homo sapiens	73-81
9973188-2	1998	Gold sodium thiomalate (GSTM) impaired the ability of interleukin 1beta (IL-1beta)-stimulated human umbilical vein endothelial cells (HUVEC) to express E-selectin and to bind PMN but had no effect on the expression of intercellular adhesion molecule 1 (ICAM-1) or on hyperadhesivity of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated PMN.	N-Formylmethionine Leucyl-Phenylalanine	327-331	interleukin 1 beta	Homo sapiens	54-71
9973188-2	1998	Gold sodium thiomalate (GSTM) impaired the ability of interleukin 1beta (IL-1beta)-stimulated human umbilical vein endothelial cells (HUVEC) to express E-selectin and to bind PMN but had no effect on the expression of intercellular adhesion molecule 1 (ICAM-1) or on hyperadhesivity of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated PMN.	N-Formylmethionine Leucyl-Phenylalanine	327-331	interleukin 1 beta	Homo sapiens	73-81
9973188-3	1998	Auranofin (AF) interacted with HUVEC and PMN adhesiveness but in opposite directions: this drug hampered IL-1beta-induced HUVEC hyperadhesiveness and expression of E-selectin and intercellular adhesion molecule 1, but augmented PMN adherence and CD18 expression.	Auranofin	0-9	interleukin 1 beta	Homo sapiens	105-113
9872417-0	1998	Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol.	7-ketocholesterol	173-190	interleukin 1 beta	Homo sapiens	22-30
9872417-3	1998	Only 7beta-hydroxycholesterol and 7-ketocholesterol were potent inducers of apoptosis and of IL-1beta secretion.	cholest-5-en-3 beta,7 alpha-diol	5-29	interleukin 1 beta	Homo sapiens	93-101
9872417-3	1998	Only 7beta-hydroxycholesterol and 7-ketocholesterol were potent inducers of apoptosis and of IL-1beta secretion.	7-ketocholesterol	34-51	interleukin 1 beta	Homo sapiens	93-101
9872417-6	1998	So, oxysterols oxidized at C7 differently injure and activate HUVECs, and the alpha- or beta-hydroxyl radical position plays a key role in apoptosis and IL-1beta secretion.	alpha- or beta-hydroxyl radical	78-109	interleukin 1 beta	Homo sapiens	153-161
9843715-5	1998	Titration of NaCl into choline chloride- or sucrose-based media restored 17-kDa IL-1beta production.	Sodium Chloride	13-17	interleukin 1 beta	Homo sapiens	80-88
9843925-15	1998	Release of GM-CSF elicited by IL-1beta was inhibited by dexamethasone but not by indomethacin.	Dexamethasone	56-69	interleukin 1 beta	Homo sapiens	30-38
9843715-5	1998	Titration of NaCl into choline chloride- or sucrose-based media restored 17-kDa IL-1beta production.	Choline	23-39	interleukin 1 beta	Homo sapiens	80-88
9843715-5	1998	Titration of NaCl into choline chloride- or sucrose-based media restored 17-kDa IL-1beta production.	Sucrose	44-51	interleukin 1 beta	Homo sapiens	80-88
9843865-3	1998	To test this hypothesis, we observed the effect of SC-19220 on the fever produced by injection of recombinant human IL-1beta (rhIL-1beta) into the lateral cerebroventricle (LCV) in conscious rats.	Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide	51-59	interleukin 1 beta	Homo sapiens	116-124
10070275-5	1998	RESULTS: The production of PGE2 by the synovial fibroblasts was increased by stimulation with IL1 beta at all concentrations tested.	Dinoprostone	27-31	interleukin 1 beta	Homo sapiens	94-102
9855588-7	1998	High partial pressure of carbon dioxide blocked the superoxide release from activated polymorphonuclear leukocytes and the secretion of interleukin 1beta from stimulated peritoneal macrophages, and human peritoneal macrophage cells were decreased by 15% and 30% and the secretion of tumor necrosis factor-alpha from peritoneal macrophages was suppressed by 85%.	Carbon Dioxide	25-39	interleukin 1 beta	Homo sapiens	136-153
10070275-7	1998	Fe-citrate inhibited the spontaneous PGE2 production by the cells in a dose dependent manner, and a maximum inhibition by Fe-citrate was observed at the concentration of 0.1 mM with IL1 beta stimulation.	ferric citrate	0-10	interleukin 1 beta	Homo sapiens	182-190
9827576-0	1998	Influence of heparin(s) on the interleukin-1-beta-induced expression of collagenase, stromelysin-1, and tissue inhibitor of metalloproteinase-1 in human gingival fibroblasts.	Heparin	13-20	interleukin 1 beta	Homo sapiens	31-49
9827576-1	1998	Here, we describe the influence of heparin(s) on the interleukin-1-beta (IL-1beta)-induced expression of collagenase (matrix metalloproteinase-1, MMP-1), stromelysin-1 (matrix metalloproteinase-3, MMP-3) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in human gingival fibroblasts (HGF).	Heparin	35-42	interleukin 1 beta	Homo sapiens	53-71
9827576-1	1998	Here, we describe the influence of heparin(s) on the interleukin-1-beta (IL-1beta)-induced expression of collagenase (matrix metalloproteinase-1, MMP-1), stromelysin-1 (matrix metalloproteinase-3, MMP-3) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in human gingival fibroblasts (HGF).	Heparin	35-42	interleukin 1 beta	Homo sapiens	73-81
9886334-6	1998	We demonstrated that IL-1 was mainly responsible for IL-6 production in the tumoural environment through a PGE2 loop.	Dinoprostone	107-111	interleukin 1 beta	Homo sapiens	21-25
9827576-3	1998	Addition of heparin to cell culture medium 1 hour following IL-1beta decreased MMP and TIMP-1 expression in a dose-dependent manner.	Heparin	12-19	interleukin 1 beta	Homo sapiens	60-68
9875677-6	1998	Furthermore, high levels of NK and LAK activities and significant increases of the numbers of cells positive for asialoGM1, IFNgamma, TNFalpha, or IL-1beta were detected in the spleen cells derived from animals given cisplatin or 5-FU as compared with those given saline (P &lt; 0.001-0.05).	Cisplatin	217-226	interleukin 1 beta	Homo sapiens	147-155
10070275-7	1998	Fe-citrate inhibited the spontaneous PGE2 production by the cells in a dose dependent manner, and a maximum inhibition by Fe-citrate was observed at the concentration of 0.1 mM with IL1 beta stimulation.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	182-190
10070275-7	1998	Fe-citrate inhibited the spontaneous PGE2 production by the cells in a dose dependent manner, and a maximum inhibition by Fe-citrate was observed at the concentration of 0.1 mM with IL1 beta stimulation.	ferric citrate	122-132	interleukin 1 beta	Homo sapiens	182-190
9815226-1	1998	Amphotericin B has been shown to cause release of cytokines, including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), from monocytes and macrophages.	Amphotericin B	0-14	interleukin 1 beta	Homo sapiens	71-88
9889411-0	1998	Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases.	Leflunomide	29-40	interleukin 1 beta	Homo sapiens	206-223
9889411-5	1998	Upon contact with T lymphocytes stimulated in the presence of 10- 5 M LF, the molar ratio of IL-1Ra/IL-1beta and TIMP-1/MMP-1 produced by THP-1 cells was enhanced 3.6- and 1.9-fold, respectively, whereas it was enhanced only 1.3- and 1.4-fold upon contact with T lymphocytes stimulated in the presence of 10- 4 M DEX.	Dexamethasone	313-316	interleukin 1 beta	Homo sapiens	100-108
9834272-5	1998	RESULTS: Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E. histolytica-infected intestinal xenografts.	Oligonucleotides	41-56	interleukin 1 beta	Homo sapiens	89-106
9877481-9	1998	Taken together our results suggest that interleukin-1beta (1-3 h)-induced potentiation of the effect of bradykinin is linked to an increased activity of thromboxane synthase and, in turn, to increased thromboxane synthesis.	Thromboxanes	153-164	interleukin 1 beta	Homo sapiens	40-57
9815226-1	1998	Amphotericin B has been shown to cause release of cytokines, including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), from monocytes and macrophages.	Amphotericin B	0-14	interleukin 1 beta	Homo sapiens	90-98
9834469-3	1998	It was found that, after 4 h of culture, IL-1beta increased prostaglandin E2 (PGE2) output approximately twofold.	Dinoprostone	60-76	interleukin 1 beta	Homo sapiens	41-49
9815226-3	1998	The effects of inhibitors of transcription and translation on amphotericin B-induced IL-1beta expression in a human monocytic cell line were also evaluated.	Amphotericin B	62-76	interleukin 1 beta	Homo sapiens	85-93
9834469-3	1998	It was found that, after 4 h of culture, IL-1beta increased prostaglandin E2 (PGE2) output approximately twofold.	Dinoprostone	78-82	interleukin 1 beta	Homo sapiens	41-49
9834469-9	1998	These results suggest that IL-1ra has partial agonist properties when used together with IL-1alpha and IL-1beta in fetal membranes by increasing cPLA2 protein levels, which leads to an increase in the production of prostaglandins.	Prostaglandins	215-229	interleukin 1 beta	Homo sapiens	103-111
9834469-5	1998	IL-1alpha was less effective than IL-1beta at stimulating PGE2 production through similar mechanisms.	Dinoprostone	58-62	interleukin 1 beta	Homo sapiens	34-42
9853559-0	1998	Suppressive effect of ethanol on the expression of hepatic asialoglycoprotein receptors augmented by interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha.	Ethanol	22-29	interleukin 1 beta	Homo sapiens	101-118
9877448-3	1998	However, IL-1beta mRNA was not expressed unless the cells had been treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	80-105	interleukin 1 beta	Homo sapiens	9-17
9877448-3	1998	However, IL-1beta mRNA was not expressed unless the cells had been treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	107-110	interleukin 1 beta	Homo sapiens	9-17
9877448-4	1998	Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 beta	Homo sapiens	19-27
9877451-5	1998	Pentoxifylline (1 mg/ml) did not influence PMA-induced TNF-alpha production, but it augmented IL-1beta-induced TNF-alpha production.	Pentoxifylline	0-14	interleukin 1 beta	Homo sapiens	94-102
9877448-4	1998	Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 beta	Homo sapiens	5-9
9877448-8	1998	On the other hand, both the expression and secretion of IL-1beta required treatment with PMA.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 beta	Homo sapiens	56-64
9845672-10	1998	Increased production of prostaglandin E2 (PGE2) in response to TNF-alpha and IL-1beta treatment was attenuated by IL-4 pretreatment, by 52% and 72%, respectively.	Dinoprostone	24-40	interleukin 1 beta	Homo sapiens	77-85
9845672-10	1998	Increased production of prostaglandin E2 (PGE2) in response to TNF-alpha and IL-1beta treatment was attenuated by IL-4 pretreatment, by 52% and 72%, respectively.	Dinoprostone	42-46	interleukin 1 beta	Homo sapiens	77-85
9851740-0	1998	Differential regulation of human alveolar macrophage-derived interleukin-1beta and tumor necrosis factor-alpha by iron.	Iron	114-118	interleukin 1 beta	Homo sapiens	61-78
9856837-7	1998	Whereas IL-1beta and tumor necrosis factor-alpha also showed an upregulation in part of these patients after exposure to the irritant sodium lauryl sulfate, IL-12 p40 mRNA was exclusively enhanced by the application of the allergen.	Sodium Dodecyl Sulfate	134-155	interleukin 1 beta	Homo sapiens	8-48
9851740-3	1998	We hypothesized that excess cellular iron interfered with the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) by AMs.	Iron	37-41	interleukin 1 beta	Homo sapiens	120-138
9851740-3	1998	We hypothesized that excess cellular iron interfered with the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) by AMs.	Iron	37-41	interleukin 1 beta	Homo sapiens	140-149
9851740-7	1998	The addition of DFA increased the release of IL-1-beta, but not TNF-alpha, from AMs from smokers and nonsmokers.	Deferoxamine	16-19	interleukin 1 beta	Homo sapiens	45-54
9851740-8	1998	The DFA augmentation of LPS-induced IL-1-beta was more pronounced in smokers" AMs than in those from non-smokers (4.5-fold vs 2.6-fold increase).	Deferoxamine	4-7	interleukin 1 beta	Homo sapiens	36-45
9858439-0	1998	Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.	diacerein	0-10	interleukin 1 beta	Homo sapiens	32-49
9851740-9	1998	The addition of FeCl3 to DFA diminished the augmenting effect on the release of IL-1-beta, suggesting that the mechanism of action involved iron chelation.	ferric chloride	16-21	interleukin 1 beta	Homo sapiens	80-89
9851740-9	1998	The addition of FeCl3 to DFA diminished the augmenting effect on the release of IL-1-beta, suggesting that the mechanism of action involved iron chelation.	Deferoxamine	25-28	interleukin 1 beta	Homo sapiens	80-89
9851740-9	1998	The addition of FeCl3 to DFA diminished the augmenting effect on the release of IL-1-beta, suggesting that the mechanism of action involved iron chelation.	Iron	140-144	interleukin 1 beta	Homo sapiens	80-89
9851740-10	1998	Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea.	Iron	32-36	interleukin 1 beta	Homo sapiens	73-82
9851740-10	1998	Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea.	Hydroxyl Radical	131-147	interleukin 1 beta	Homo sapiens	73-82
9851740-10	1998	Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea.	1,3-dimethylthiourea	162-178	interleukin 1 beta	Homo sapiens	73-82
9858439-11	1998	Naproxen, however, showed only a slight inhibition of IL-1beta induced NO production at the highest dose used, 90 microg/ml.	Naproxen	0-8	interleukin 1 beta	Homo sapiens	54-62
9858439-0	1998	Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.	Nitric Oxide	71-83	interleukin 1 beta	Homo sapiens	32-49
9832620-8	1998	SB203580, a specific inhibitor of p38 MAP kinase, significantly inhibited IL-1beta-induced IL-6 and stromelysin-1 production by both parental FLSs and MH7A cells; although PD098059, an inhibitor of the p42/p44 MAP kinase pathway, did not affect it.	SB 203580	0-8	interleukin 1 beta	Homo sapiens	74-82
9832620-9	1998	Our results clearly indicate the usefulness of MH7A cells for investigating the regulation of rheumatoid FLSs and the IL-1 signal transduction pathway to develop future RA therapy.	Radium	169-171	interleukin 1 beta	Homo sapiens	118-122
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dinoprostone	70-86	interleukin 1 beta	Homo sapiens	31-48
9853284-6	1998	RESULTS: Apical stimulation of HPMC with IL-1 beta or TNF alpha resulted in a time and dose dependent up-regulation of IL-8, MCP-1 and RANTES mRNA expression and synthesis.	hydroxypropylmethylcellulose-lactose matrix	31-35	interleukin 1 beta	Homo sapiens	41-50
9872366-9	1998	Moreover, interleukin (IL-1beta) was able to increase sICAM-1 shedding from endometrial cells in a concentration-dependent manner and this IL-1beta-mediated induction could be slightly enhanced by oestradiol.	Estradiol	197-207	interleukin 1 beta	Homo sapiens	23-31
9872366-9	1998	Moreover, interleukin (IL-1beta) was able to increase sICAM-1 shedding from endometrial cells in a concentration-dependent manner and this IL-1beta-mediated induction could be slightly enhanced by oestradiol.	Estradiol	197-207	interleukin 1 beta	Homo sapiens	139-147
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dinoprostone	70-86	interleukin 1 beta	Homo sapiens	50-58
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dinoprostone	88-92	interleukin 1 beta	Homo sapiens	31-48
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dinoprostone	88-92	interleukin 1 beta	Homo sapiens	50-58
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dexamethasone	108-121	interleukin 1 beta	Homo sapiens	31-48
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dexamethasone	108-121	interleukin 1 beta	Homo sapiens	50-58
9822711-8	1998	Repression of IL-1beta-induced PGE2 release, COX activity, and COX-2 protein by actinomycin D was only effective within the first hour following IL-1beta treatment, while dexamethasone was effective when added up to 10 h later, suggesting a functional role for post-transcriptional mechanisms of repression.	Dinoprostone	31-35	interleukin 1 beta	Homo sapiens	14-22
9822711-8	1998	Repression of IL-1beta-induced PGE2 release, COX activity, and COX-2 protein by actinomycin D was only effective within the first hour following IL-1beta treatment, while dexamethasone was effective when added up to 10 h later, suggesting a functional role for post-transcriptional mechanisms of repression.	Dactinomycin	80-93	interleukin 1 beta	Homo sapiens	14-22
9848350-6	1998	FINDINGS: After activation with interleukin-1beta or lipopolysaccharide, HIMEC from the chronically inflamed tissue in all three patients with inflammatory bowel disease bound twice as many polymorphonuclear leucocytes and U937 cells as endothelial cells from uninvolved tissue.	himec	73-78	interleukin 1 beta	Homo sapiens	32-49
9822711-8	1998	Repression of IL-1beta-induced PGE2 release, COX activity, and COX-2 protein by actinomycin D was only effective within the first hour following IL-1beta treatment, while dexamethasone was effective when added up to 10 h later, suggesting a functional role for post-transcriptional mechanisms of repression.	Dactinomycin	80-93	interleukin 1 beta	Homo sapiens	145-153
9822711-8	1998	Repression of IL-1beta-induced PGE2 release, COX activity, and COX-2 protein by actinomycin D was only effective within the first hour following IL-1beta treatment, while dexamethasone was effective when added up to 10 h later, suggesting a functional role for post-transcriptional mechanisms of repression.	Dexamethasone	171-184	interleukin 1 beta	Homo sapiens	14-22
9810029-3	1998	We have examined the inhibitory effect of 1.8-cineole on LPS-and IL1beta-stimulated mediator production by human monocytes in vitro.	Eucalyptol	42-53	interleukin 1 beta	Homo sapiens	65-72
9810029-4	1998	For the first time, we report on a dose-dependent and highly significant inhibition of production of tumor necrosis factor-alpha, interleukin-1beta, leukotriene B4 and thromboxane B2 by 1.8-cineole.	Eucalyptol	186-197	interleukin 1 beta	Homo sapiens	130-147
9792671-8	1998	The increase is approximately 5-fold above control values, is comparable to the induction elicited by IL-1beta and could be attenuated with dexamethasone but not by SC 58125, a prostaglandin endoperoxide H synthase-2 (PGHS-2)-selective inhibitor.	Dexamethasone	140-153	interleukin 1 beta	Homo sapiens	102-110
9820546-3	1998	The NO synthase inhibitors aminoguanidine and NG-nitro-L-arginine methyl ester (L-NAME) blocked IL-8 release by approximately 90% in response to LPS (1 microg/ml), but did not affect the production of IL-1beta or TNF-alpha.	pimagedine	27-41	interleukin 1 beta	Homo sapiens	201-209
9820546-3	1998	The NO synthase inhibitors aminoguanidine and NG-nitro-L-arginine methyl ester (L-NAME) blocked IL-8 release by approximately 90% in response to LPS (1 microg/ml), but did not affect the production of IL-1beta or TNF-alpha.	NG-Nitroarginine Methyl Ester	80-86	interleukin 1 beta	Homo sapiens	201-209
9780320-1	1998	Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin output by cultures of human amnion cells.	Prostaglandins	76-89	interleukin 1 beta	Homo sapiens	0-17
9822011-8	1998	Ketamine additionally decreased the concentration of interleukin (IL)-1beta (14.8% [median]; 12.0-18.0 [25-75 percentile]).	Ketamine	0-8	interleukin 1 beta	Homo sapiens	53-75
9815040-4	1998	Cytochemistry of parietal cell IL-1 receptor was performed with biotinylated recombinant human IL-1beta, visualized by avidin-coupled fluorescein.	Fluorescein	134-145	interleukin 1 beta	Homo sapiens	95-103
9870074-4	1998	RESULTS: Both IL-10 and IL-4 inhibited IL-1 beta- and TNF-alpha-induced PGE2 production but had no significant effects on the production of PGE2 under basal conditions.	Dinoprostone	72-76	interleukin 1 beta	Homo sapiens	39-48
9870076-7	1998	The maximal inhibition of IL-1 beta-stimulated PGE2 production (to 28% +/- 10% of control) was seen at 10 ng/ml of IL-4 or IL-13.	Dinoprostone	47-51	interleukin 1 beta	Homo sapiens	26-35
9811059-6	1998	MTX had fewer effects on phenotypic differentiation of human BMMC and PBMC, but did stimulate IL-1Ra release and inhibit IL-1beta synthesis in BMMC.	Methotrexate	0-3	interleukin 1 beta	Homo sapiens	121-129
9780320-1	1998	Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin output by cultures of human amnion cells.	Prostaglandins	76-89	interleukin 1 beta	Homo sapiens	19-27
9863663-10	1998	Our study demonstrates that COX-2 induction and the consequent release of prostanoids plays a crucial role in IL-1beta induced attenuation of human ASM cell cyclic AMP response to ISO.	Prostaglandins	74-85	interleukin 1 beta	Homo sapiens	110-118
9863663-10	1998	Our study demonstrates that COX-2 induction and the consequent release of prostanoids plays a crucial role in IL-1beta induced attenuation of human ASM cell cyclic AMP response to ISO.	Cyclic AMP	157-167	interleukin 1 beta	Homo sapiens	110-118
9863663-0	1998	Role of cyclo-oxygenase-2 induction in interleukin-1beta induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline.	Cyclic AMP	121-131	interleukin 1 beta	Homo sapiens	39-56
9863663-0	1998	Role of cyclo-oxygenase-2 induction in interleukin-1beta induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline.	Isoproterenol	158-170	interleukin 1 beta	Homo sapiens	39-56
9863663-3	1998	We have reported that IL-1beta induces cyclo-oxygenase-2 (COX-2) in human ASM cells and results in a marked increase in prostanoid generation with PGE2 and PGI2 as the major products.	Prostaglandins	120-130	interleukin 1 beta	Homo sapiens	22-30
9863663-3	1998	We have reported that IL-1beta induces cyclo-oxygenase-2 (COX-2) in human ASM cells and results in a marked increase in prostanoid generation with PGE2 and PGI2 as the major products.	Dinoprostone	147-151	interleukin 1 beta	Homo sapiens	22-30
9804346-8	1998	Based on previous data from clinical studies in human dermal fibrosis remodeling, and the results presented here, we suggest that collagen-polyvinylpyrrolidone modulates extracellular matrix turnover, mainly of collagen, because expression levels of IL-1beta, TNF-alpha, TGF-beta1, and PDGF were diminished.	Povidone	139-159	interleukin 1 beta	Homo sapiens	250-258
9863663-3	1998	We have reported that IL-1beta induces cyclo-oxygenase-2 (COX-2) in human ASM cells and results in a marked increase in prostanoid generation with PGE2 and PGI2 as the major products.	Epoprostenol	156-160	interleukin 1 beta	Homo sapiens	22-30
9863663-4	1998	We investigated the role of COX-2 induction and prostanoid release (measured as PGE2) in IL-1beta induced attenuation of cyclic AMP generation in response to the beta-adrenoceptor agonist isoprenaline (ISO).	Prostaglandins	48-58	interleukin 1 beta	Homo sapiens	89-97
9863663-4	1998	We investigated the role of COX-2 induction and prostanoid release (measured as PGE2) in IL-1beta induced attenuation of cyclic AMP generation in response to the beta-adrenoceptor agonist isoprenaline (ISO).	Dinoprostone	80-84	interleukin 1 beta	Homo sapiens	89-97
9863663-4	1998	We investigated the role of COX-2 induction and prostanoid release (measured as PGE2) in IL-1beta induced attenuation of cyclic AMP generation in response to the beta-adrenoceptor agonist isoprenaline (ISO).	Cyclic AMP	121-131	interleukin 1 beta	Homo sapiens	89-97
9863663-4	1998	We investigated the role of COX-2 induction and prostanoid release (measured as PGE2) in IL-1beta induced attenuation of cyclic AMP generation in response to the beta-adrenoceptor agonist isoprenaline (ISO).	Isoproterenol	188-200	interleukin 1 beta	Homo sapiens	89-97
9863663-5	1998	Pre-treatment of human ASM cells with IL-1beta significantly attenuated cyclic AMP generation in response to high concentrations of ISO (1.0-10.0 microM) in a time- and concentration-dependent manner.	Cyclic AMP	72-82	interleukin 1 beta	Homo sapiens	38-46
9863663-8	1998	COX substrate arachidonic acid time- and concentration-dependently mimicked IL-1beta induced attenuation and the effect was prevented by the non-selective COX inhibitors Ind and flurbiprofen, but not by NS-398, CHX and Dex.	Arachidonic Acid	14-30	interleukin 1 beta	Homo sapiens	76-84
9863663-8	1998	COX substrate arachidonic acid time- and concentration-dependently mimicked IL-1beta induced attenuation and the effect was prevented by the non-selective COX inhibitors Ind and flurbiprofen, but not by NS-398, CHX and Dex.	Indomethacin	170-173	interleukin 1 beta	Homo sapiens	76-84
9863663-8	1998	COX substrate arachidonic acid time- and concentration-dependently mimicked IL-1beta induced attenuation and the effect was prevented by the non-selective COX inhibitors Ind and flurbiprofen, but not by NS-398, CHX and Dex.	Flurbiprofen	178-190	interleukin 1 beta	Homo sapiens	76-84
9863663-8	1998	COX substrate arachidonic acid time- and concentration-dependently mimicked IL-1beta induced attenuation and the effect was prevented by the non-selective COX inhibitors Ind and flurbiprofen, but not by NS-398, CHX and Dex.	Cycloheximide	211-214	interleukin 1 beta	Homo sapiens	76-84
9863663-8	1998	COX substrate arachidonic acid time- and concentration-dependently mimicked IL-1beta induced attenuation and the effect was prevented by the non-selective COX inhibitors Ind and flurbiprofen, but not by NS-398, CHX and Dex.	Dexamethasone	219-222	interleukin 1 beta	Homo sapiens	76-84
9779823-1	1998	In a recent communication, we demonstrated that prostaglandin E2 (PGE2) lowers basal while it ablates interleukin-1beta((IL-1beta) and transforming growth factor-beta (TGFbeta) upregulated lysyl oxidase (LO) mRNA levels.	Dinoprostone	48-64	interleukin 1 beta	Homo sapiens	102-119
9779823-1	1998	In a recent communication, we demonstrated that prostaglandin E2 (PGE2) lowers basal while it ablates interleukin-1beta((IL-1beta) and transforming growth factor-beta (TGFbeta) upregulated lysyl oxidase (LO) mRNA levels.	Dinoprostone	48-64	interleukin 1 beta	Homo sapiens	121-129
9779823-1	1998	In a recent communication, we demonstrated that prostaglandin E2 (PGE2) lowers basal while it ablates interleukin-1beta((IL-1beta) and transforming growth factor-beta (TGFbeta) upregulated lysyl oxidase (LO) mRNA levels.	Dinoprostone	66-70	interleukin 1 beta	Homo sapiens	102-119
9779823-1	1998	In a recent communication, we demonstrated that prostaglandin E2 (PGE2) lowers basal while it ablates interleukin-1beta((IL-1beta) and transforming growth factor-beta (TGFbeta) upregulated lysyl oxidase (LO) mRNA levels.	Dinoprostone	66-70	interleukin 1 beta	Homo sapiens	121-129
9779823-7	1998	In a similar manner to PGE2, 11-deoxy PGE1 decreases basal and TGF-beta induced type I collagen alpha1 (COL) mRNA, basal and IL-1beta induced LO mRNA while it increases COX1 mRNA.	11-deoxy	29-37	interleukin 1 beta	Homo sapiens	125-133
9779823-7	1998	In a similar manner to PGE2, 11-deoxy PGE1 decreases basal and TGF-beta induced type I collagen alpha1 (COL) mRNA, basal and IL-1beta induced LO mRNA while it increases COX1 mRNA.	Alprostadil	38-42	interleukin 1 beta	Homo sapiens	125-133
9859867-0	1998	Interleukin-1beta and bacterial endotoxin change the metabolism of prostaglandins E2 and F2alpha in intact term fetal membranes.	Dinoprostone	67-84	interleukin 1 beta	Homo sapiens	0-17
9783809-0	1998	Retinoic acid differentially regulates interleukin-1beta and interleukin-1 receptor antagonist production by human alveolar macrophages.	Tretinoin	0-13	interleukin 1 beta	Homo sapiens	39-56
9783809-4	1998	In the present study, we examined the effect of RA on IL-1beta and IL-1ra production by human alveolar macrophages in order to clarify the mechanism in pulmonary infiltration of neutrophils, since IL-1 has been shown to initiate neutrophil recruitment into the lung through up-regulated expression of adhesion molecules on vascular endothelium.	Tretinoin	48-50	interleukin 1 beta	Homo sapiens	54-62
9783809-4	1998	In the present study, we examined the effect of RA on IL-1beta and IL-1ra production by human alveolar macrophages in order to clarify the mechanism in pulmonary infiltration of neutrophils, since IL-1 has been shown to initiate neutrophil recruitment into the lung through up-regulated expression of adhesion molecules on vascular endothelium.	Tretinoin	48-50	interleukin 1 beta	Homo sapiens	54-58
9783809-5	1998	RA enhanced IL-1beta and inhibited IL-1ra production by 4beta phorbol 12beta-myristate-13alpha acetate (PMA)- and lipopolysaccharide (LPS)-stimulated human alveolar macrophages.	Tretinoin	0-2	interleukin 1 beta	Homo sapiens	12-20
9859867-0	1998	Interleukin-1beta and bacterial endotoxin change the metabolism of prostaglandins E2 and F2alpha in intact term fetal membranes.	f2alpha	89-96	interleukin 1 beta	Homo sapiens	0-17
9859867-2	1998	This study used an intact fetal membrane disk model to investigate the regulation of PGE2 and PGF2alpha metabolism by interleukin-1 beta (IL-1beta) and bacterial endotoxin [lipopolysaccharide (LPS)].	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	118-136
9859867-2	1998	This study used an intact fetal membrane disk model to investigate the regulation of PGE2 and PGF2alpha metabolism by interleukin-1 beta (IL-1beta) and bacterial endotoxin [lipopolysaccharide (LPS)].	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	138-146
9859867-2	1998	This study used an intact fetal membrane disk model to investigate the regulation of PGE2 and PGF2alpha metabolism by interleukin-1 beta (IL-1beta) and bacterial endotoxin [lipopolysaccharide (LPS)].	Dinoprost	94-103	interleukin 1 beta	Homo sapiens	118-136
9859867-2	1998	This study used an intact fetal membrane disk model to investigate the regulation of PGE2 and PGF2alpha metabolism by interleukin-1 beta (IL-1beta) and bacterial endotoxin [lipopolysaccharide (LPS)].	Dinoprost	94-103	interleukin 1 beta	Homo sapiens	138-146
9859867-5	1998	Levels of prostaglandin metabolites were generally decreased following incubation with IL-1beta or LPS, which is consistent with a decrease in the activity of 15-hydroxyprostaglandin dehydrogenase (PGDH).	Prostaglandins	10-23	interleukin 1 beta	Homo sapiens	87-95
9859867-6	1998	It is concluded that IL-1beta and LPS moderately decrease the metabolism of prostaglandins, which may contribute to increasing the local levels of active prostaglandins induced by these stimuli.	Prostaglandins	76-90	interleukin 1 beta	Homo sapiens	21-29
9859867-6	1998	It is concluded that IL-1beta and LPS moderately decrease the metabolism of prostaglandins, which may contribute to increasing the local levels of active prostaglandins induced by these stimuli.	Prostaglandins	154-168	interleukin 1 beta	Homo sapiens	21-29
9790925-2	1998	In this study we identify a selective and potent antisense oligonucleotide to RhoA (ISIS 17131) and investigate its effect on JNK activation induced by IL-1beta and H2O2 in A549 cells.	Oligonucleotides	59-74	interleukin 1 beta	Homo sapiens	152-160
9780184-7	1998	The NO donor S-nitroso-N-acetyl-DL-penicillamine inhibited caspase-1 activity in cells as well as the activity of purified recombinant caspase-1 and also prevented the cleavage of pro-IL-1beta and pro-IGIF by recombinant caspase-1.	snap	13-48	interleukin 1 beta	Homo sapiens	180-192
9777957-6	1998	Tumor necrosis factor-alpha and interleukin-1beta also inhibited thymidine incorporation, but to a lesser degree.	Thymidine	65-74	interleukin 1 beta	Homo sapiens	32-49
9794205-13	1998	Expression of several proinflammatory cytokines including TNF-alpha, IL-6, IL-1beta, and IFN-gamma were also elevated in Av-exposed animals and modulated by dexamethasone.	Dexamethasone	157-170	interleukin 1 beta	Homo sapiens	75-83
9772043-9	1998	Prednisolone significantly decreased the expression of CD64 and the release of TNF-alpha and IL-1beta, but did not alter the expression of CD25 and CD71.	Prednisolone	0-12	interleukin 1 beta	Homo sapiens	93-101
9790925-5	1998	Additionally, Wortmannin, a potent inhibitor of the PI 3-kinase and phospholipase A2 (PLA2), and AACOCF3, also a PLA2 inhibitor, were able to inhibit JNK activation induced by H2O2, but they had no effect on JNK activation when stimulated by IL-1beta.	Wortmannin	14-24	interleukin 1 beta	Homo sapiens	242-250
9790925-5	1998	Additionally, Wortmannin, a potent inhibitor of the PI 3-kinase and phospholipase A2 (PLA2), and AACOCF3, also a PLA2 inhibitor, were able to inhibit JNK activation induced by H2O2, but they had no effect on JNK activation when stimulated by IL-1beta.	Hydrogen Peroxide	176-180	interleukin 1 beta	Homo sapiens	242-250
9755052-5	1998	Treatment for 24 h with interleukin-1beta (IL-1beta; 10 ng/ml) or tumor necrosis factor-alpha (50 ng/ml), respectively, elicited maximal 25- and 6-fold inductions of PGE2 synthesis in CCD-18Co cultures and similar results in primary fibroblast cultures; maximal inductions with IL-1beta in colonic epithelial cell lines were from zero to fivefold.	Dinoprostone	166-170	interleukin 1 beta	Homo sapiens	24-41
9755052-5	1998	Treatment for 24 h with interleukin-1beta (IL-1beta; 10 ng/ml) or tumor necrosis factor-alpha (50 ng/ml), respectively, elicited maximal 25- and 6-fold inductions of PGE2 synthesis in CCD-18Co cultures and similar results in primary fibroblast cultures; maximal inductions with IL-1beta in colonic epithelial cell lines were from zero to fivefold.	Dinoprostone	166-170	interleukin 1 beta	Homo sapiens	43-51
9755052-5	1998	Treatment for 24 h with interleukin-1beta (IL-1beta; 10 ng/ml) or tumor necrosis factor-alpha (50 ng/ml), respectively, elicited maximal 25- and 6-fold inductions of PGE2 synthesis in CCD-18Co cultures and similar results in primary fibroblast cultures; maximal inductions with IL-1beta in colonic epithelial cell lines were from zero to fivefold.	Dinoprostone	166-170	interleukin 1 beta	Homo sapiens	278-286
9763540-4	1998	After stimulation with interleukin-1beta, tumor necrosis factor-alpha, interferon-gamma, and bacterial lipopolysaccharide, both venous and arterial SMC expressed COX-2 protein and released increased amounts of prostaglandins.	Prostaglandins	210-224	interleukin 1 beta	Homo sapiens	23-69
9893571-0	1998	Hyaluronan production in human rheumatoid fibroblastic synovial lining cells is increased by interleukin 1 beta but inhibited by transforming growth factor beta 1.	Hyaluronic Acid	0-10	interleukin 1 beta	Homo sapiens	93-111
9781725-9	1998	MEASUREMENTS AND MAIN RESULTS: Exposure to TNF-alpha and IL-1beta led to significant decreases in neutrophil filterability, which was attenuated by cytochalasin D pretreatment.	Cytochalasin D	148-162	interleukin 1 beta	Homo sapiens	57-65
9825753-0	1998	Increased production of nitric oxide stimulated by interleukin-1beta in peripheral blood mononuclear cells in patients with systemic sclerosis.	Nitric Oxide	24-36	interleukin 1 beta	Homo sapiens	51-68
9744992-8	1998	Alendronate treatment of peripheral blood mononuclear cells also resulted in an increased production of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma).	Alendronate	0-11	interleukin 1 beta	Homo sapiens	104-121
9744992-8	1998	Alendronate treatment of peripheral blood mononuclear cells also resulted in an increased production of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma).	Alendronate	0-11	interleukin 1 beta	Homo sapiens	123-131
9793002-9	1998	In cell cultures, the LPS-induced release of the inflammatory cytokines doubled for IL-1beta (P &lt; 0.0001) and for IL-1ra (P &lt; 0.0001).	lps	22-25	interleukin 1 beta	Homo sapiens	84-92
9811536-3	1998	Interleukin (IL)-1 and tumour necrosis factor (TNF)-alpha suppress 17beta-estradiol (E2) and progesterone release from granulosa and luteal cells in vitro.	Estradiol	67-83	interleukin 1 beta	Homo sapiens	0-18
9811536-3	1998	Interleukin (IL)-1 and tumour necrosis factor (TNF)-alpha suppress 17beta-estradiol (E2) and progesterone release from granulosa and luteal cells in vitro.	Progesterone	93-105	interleukin 1 beta	Homo sapiens	0-18
9867255-5	1998	17beta-estradiol (E2) markedly enhanced lipopolysaccharide- (LPS) induced IL-1beta promoter-driven CAT activity in a dose-dependent manner.	Estradiol	0-16	interleukin 1 beta	Homo sapiens	74-82
9811532-10	1998	The maximal inhibitory effect of budesonide was seen at 10(-8) M. The inhibition of IL-12 production was significantly higher than the inhibition of GM-CSF (P&lt;0.01) or IL-1beta (P&lt;0.001).	Budesonide	33-43	interleukin 1 beta	Homo sapiens	171-179
9802683-13	1998	The dose of steroids showed a significant positive correlation with the amount of decrease in IL-1beta.	Steroids	12-20	interleukin 1 beta	Homo sapiens	94-102
9797107-11	1998	CONCLUSION(S): Induction of COX-2 by IL-1beta and PMA suggests that COX-2 and prostaglandin have important roles in the growth and differentiation of endometrial stromal cells.	Prostaglandins	78-91	interleukin 1 beta	Homo sapiens	37-45
9824485-3	1998	We performed an analysis of the mechanisms by which two PKC inhibitors, Calphostin C and Staurosporine, prevent the FN-induced IL-1beta response.	calphostin C	72-84	interleukin 1 beta	Homo sapiens	127-135
9751192-3	1998	The synergistic neurotoxic activity of hypoxia and interleukin-1beta was dependent on de novo expression of inducible nitric oxide synthase (iNOS) and on nitric oxide (NO) production in astrocytes.	Nitric Oxide	118-130	interleukin 1 beta	Homo sapiens	51-68
9824485-3	1998	We performed an analysis of the mechanisms by which two PKC inhibitors, Calphostin C and Staurosporine, prevent the FN-induced IL-1beta response.	Staurosporine	89-102	interleukin 1 beta	Homo sapiens	127-135
9824485-12	1998	In contrast, Staurosporine prevented secretion of IL-1beta by unknown mechanisms.	Staurosporine	13-26	interleukin 1 beta	Homo sapiens	50-58
9818745-1	1998	Amphotericin B is an antifungal drug associated with side effects such as fever and chills, symptoms which may be mediated by pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNFalpha).	Amphotericin B	0-14	interleukin 1 beta	Homo sapiens	161-178
9818745-1	1998	Amphotericin B is an antifungal drug associated with side effects such as fever and chills, symptoms which may be mediated by pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNFalpha).	Amphotericin B	0-14	interleukin 1 beta	Homo sapiens	180-188
9786635-6	1998	The results demonstrate a significant concentration-dependent decrease in 3H-thymidine incorporation in response to PDGF-AA following IL-1 beta treatment (p &lt; 0.001).	Tritium	74-76	interleukin 1 beta	Homo sapiens	134-143
9786635-6	1998	The results demonstrate a significant concentration-dependent decrease in 3H-thymidine incorporation in response to PDGF-AA following IL-1 beta treatment (p &lt; 0.001).	Thymidine	77-86	interleukin 1 beta	Homo sapiens	134-143
11367742-1	1998	The effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on IL-1 beta-induced fever and release of hypothalamic cAMP was observed in the present work.	Cyclic AMP	118-122	interleukin 1 beta	Homo sapiens	66-75
9790312-4	1998	Incubation of rSAA, plasma HDL (which contains &lt; or = 30 microg/ml of SAA) or HDL-rSAA complex with THP-1 cells induced synthesis of IL-1beta, IL-1ra and sTNFR-II protein and mRNA.	rsaa	14-18	interleukin 1 beta	Homo sapiens	136-144
11367742-2	1998	The results showed that alpha-MSH markedly suppressed febrile response (P &lt; 0.05) and decreased the cAMP content in hypothalamus in response to icv injection of IL-1 beta (P &lt; 0.01).	Cyclic AMP	103-107	interleukin 1 beta	Homo sapiens	164-173
9790312-4	1998	Incubation of rSAA, plasma HDL (which contains &lt; or = 30 microg/ml of SAA) or HDL-rSAA complex with THP-1 cells induced synthesis of IL-1beta, IL-1ra and sTNFR-II protein and mRNA.	rsaa	85-89	interleukin 1 beta	Homo sapiens	136-144
11367742-3	1998	The cAMP content of the medium in which the hypothalamic was incubated for 40 min in the presence of IL-1 beta was significantly increased (P &lt; 0.01).	Cyclic AMP	4-8	interleukin 1 beta	Homo sapiens	101-110
11367742-5	1998	The results indicate that the inhibitory effect of alpha-MSH on the enhanced synthesis and release of cAMP in hypothalamus exposed to IL-1 beta might be one of the mechanisms of suppressing fever induced by IL-1 beta.	Cyclic AMP	102-106	interleukin 1 beta	Homo sapiens	134-143
11367742-5	1998	The results indicate that the inhibitory effect of alpha-MSH on the enhanced synthesis and release of cAMP in hypothalamus exposed to IL-1 beta might be one of the mechanisms of suppressing fever induced by IL-1 beta.	Cyclic AMP	102-106	interleukin 1 beta	Homo sapiens	207-216
9743373-0	1998	Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through prostaglandin-dependent and -independent mechanisms.	Prostaglandins	147-160	interleukin 1 beta	Homo sapiens	129-138
9751081-0	1998	Induction by interleukin-1beta peptide of prostaglandin E2 formation via enhanced prostaglandin H synthase-2 expression in 3T6 fibroblasts.	Dinoprostone	42-58	interleukin 1 beta	Homo sapiens	13-30
9751081-2	1998	Only the IL-1beta fragment (208-240) enhanced body temperature, although both IL-1beta (208-240) and IL-1alpha (223-250) stimulated prostaglandin E2 (PGE2) production in vitro.	Dinoprostone	132-148	interleukin 1 beta	Homo sapiens	78-86
9751081-2	1998	Only the IL-1beta fragment (208-240) enhanced body temperature, although both IL-1beta (208-240) and IL-1alpha (223-250) stimulated prostaglandin E2 (PGE2) production in vitro.	Dinoprostone	150-154	interleukin 1 beta	Homo sapiens	78-86
9743339-4	1998	Here we show that PGE2, although it does not induce final DC maturation by itself, synergizes with IL-1beta and TNF-alpha, and allows their effectiveness at 100-fold lower concentrations.	Dinoprostone	18-22	interleukin 1 beta	Homo sapiens	99-107
9738019-2	1998	Our previous studies investigating the mechanisms of this induction demonstrated that the mRNAs of both interleukin-1 (IL-1) isoforms, IL-1alpha and IL-1beta, are induced by serotonin and that the induction of IL-1 is required for the subsequent induction of collagenase.	Serotonin	174-183	interleukin 1 beta	Homo sapiens	149-157
9917859-6	1998	IL-18 is a member of the IL-1 family, and like IL-1 beta, proIL-18 is cleaved by ICE to yield an active molecule.	proil	58-63	interleukin 1 beta	Homo sapiens	47-56
9733787-3	1998	A pyridinylimidazole compound, SB203580, inhibited p38 MAP kinase activity in vivo, since the activity of MAPKAP kinase-2 (a substrate of p38 MAP kinase) in IL-1beta-stimulated FLSs was totally suppressed by it.	CHEMBL96741	2-20	interleukin 1 beta	Homo sapiens	157-165
9733787-3	1998	A pyridinylimidazole compound, SB203580, inhibited p38 MAP kinase activity in vivo, since the activity of MAPKAP kinase-2 (a substrate of p38 MAP kinase) in IL-1beta-stimulated FLSs was totally suppressed by it.	SB 203580	31-39	interleukin 1 beta	Homo sapiens	157-165
9730996-5	1998	There was a significant (p &lt; 0.05) decrease in sputum leukocyte density and IL-1beta, IL-8, and LTB4 after fluticasone treatment.	Fluticasone	110-121	interleukin 1 beta	Homo sapiens	79-87
9742939-0	1998	Soluble IL-1 receptor type I binds to human dermal fibroblasts and induces calcium flux.	Calcium	75-82	interleukin 1 beta	Homo sapiens	8-12
9742939-5	1998	Neutralizing antibodies against IL-1beta also abolished calcium mobilization stimulated with IL-1sR I indicating that IL-1beta is involved.	Calcium	56-63	interleukin 1 beta	Homo sapiens	32-40
9742939-5	1998	Neutralizing antibodies against IL-1beta also abolished calcium mobilization stimulated with IL-1sR I indicating that IL-1beta is involved.	Calcium	56-63	interleukin 1 beta	Homo sapiens	118-126
9659617-2	1998	Incubation of macrophages with cobalt chromium led to release of tumor necrosis factor-alpha (TNF-alpha) and prostaglandin E2 (PGE2), but did not lead to release of interleukin-1 beta (IL-1 beta) or interleukin 6 (IL-6).	cobalt chromium	31-46	interleukin 1 beta	Homo sapiens	185-194
9728043-0	1998	Prostanoids mediate IL-1beta-induced beta-adrenergic hyporesponsiveness in human airway smooth muscle cells.	Prostaglandins	0-11	interleukin 1 beta	Homo sapiens	20-28
9728043-2	1998	The purpose of this study was to determine whether prostanoids released as a result of cyclooxygenase-2 (COX-2) induction by IL-1beta contribute to this effect of the cytokine.	Prostaglandins	51-62	interleukin 1 beta	Homo sapiens	125-133
9728043-4	1998	IL-1beta (20 ng/ml for 22 h) reduced the ability of the beta-agonist isoproterenol (Iso) to decrease stiffness of HASM cells as measured by magnetic twisting cytometry.	Isoproterenol	69-82	interleukin 1 beta	Homo sapiens	0-8
9728043-4	1998	IL-1beta (20 ng/ml for 22 h) reduced the ability of the beta-agonist isoproterenol (Iso) to decrease stiffness of HASM cells as measured by magnetic twisting cytometry.	Isoproterenol	84-87	interleukin 1 beta	Homo sapiens	0-8
9728043-5	1998	The effect of IL-1beta on Iso-induced changes in cell stiffness was abolished by nonselective [indomethacin (Indo), 10(-6) M] and selective (NS-398, 10(-5) M) COX-2 inhibitors.	Indomethacin	95-107	interleukin 1 beta	Homo sapiens	14-22
9728043-5	1998	The effect of IL-1beta on Iso-induced changes in cell stiffness was abolished by nonselective [indomethacin (Indo), 10(-6) M] and selective (NS-398, 10(-5) M) COX-2 inhibitors.	Indomethacin	109-113	interleukin 1 beta	Homo sapiens	14-22
9728043-5	1998	The effect of IL-1beta on Iso-induced changes in cell stiffness was abolished by nonselective [indomethacin (Indo), 10(-6) M] and selective (NS-398, 10(-5) M) COX-2 inhibitors.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	141-147	interleukin 1 beta	Homo sapiens	14-22
9728043-6	1998	Indo and NS-398 also inhibited both the increased basal cAMP and the decreases in Iso-stimulated cAMP production induced by IL-1beta.	Indomethacin	0-4	interleukin 1 beta	Homo sapiens	124-132
9728043-6	1998	Indo and NS-398 also inhibited both the increased basal cAMP and the decreases in Iso-stimulated cAMP production induced by IL-1beta.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	9-15	interleukin 1 beta	Homo sapiens	124-132
9821108-3	1998	Combined treatment with IL-1 beta and IFN-gamma caused greater inhibition of TGF-beta secretion compared to treatment with IFN-gamma, and almost the same levels of inhibition as treatment with vincristine and etoposide.	Vincristine	193-204	interleukin 1 beta	Homo sapiens	24-33
9728043-6	1998	Indo and NS-398 also inhibited both the increased basal cAMP and the decreases in Iso-stimulated cAMP production induced by IL-1beta.	Cyclic AMP	97-101	interleukin 1 beta	Homo sapiens	124-132
9728043-7	1998	IL-1beta (20 ng/ml for 22 h) caused an increase in both basal (15-fold) and arachidonic acid (AA)-stimulated (10-fold) PGE2 release.	Arachidonic Acid	76-92	interleukin 1 beta	Homo sapiens	0-8
9728043-7	1998	IL-1beta (20 ng/ml for 22 h) caused an increase in both basal (15-fold) and arachidonic acid (AA)-stimulated (10-fold) PGE2 release.	Dinoprostone	119-123	interleukin 1 beta	Homo sapiens	0-8
9728043-8	1998	Indo blocked basal and AA-stimulated PGE2 release in both control and IL-1beta-treated cells.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	70-78
9728043-9	1998	NS-398 also markedly reduced basal and AA-stimulated PGE2 release in IL-1beta-treated cells but had no significant effect on AA-stimulated PGE2 release in control cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	interleukin 1 beta	Homo sapiens	69-77
9728043-9	1998	NS-398 also markedly reduced basal and AA-stimulated PGE2 release in IL-1beta-treated cells but had no significant effect on AA-stimulated PGE2 release in control cells.	Dinoprostone	53-57	interleukin 1 beta	Homo sapiens	69-77
9728043-11	1998	Exogenously administered PGE2 (10(-7) M, 22 h) caused a significant reduction in the ability of Iso to decrease cell stiffness, mimicking the effects of IL-1beta.	Dinoprostone	25-29	interleukin 1 beta	Homo sapiens	153-161
9728043-12	1998	Cycloheximide (10 microg/ml for 24 h), an inhibitor of protein synthesis, also abolished the effects of IL-1beta on Iso-induced cell stiffness changes and cAMP formation.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	104-112
9728043-12	1998	Cycloheximide (10 microg/ml for 24 h), an inhibitor of protein synthesis, also abolished the effects of IL-1beta on Iso-induced cell stiffness changes and cAMP formation.	Cyclic AMP	155-159	interleukin 1 beta	Homo sapiens	104-112
9728043-13	1998	In summary, our results indicate that IL-1beta significantly increases prostanoid release by HASM cells as a result of increased COX-2 expression.	Prostaglandins	71-81	interleukin 1 beta	Homo sapiens	38-46
9751850-4	1998	HNMEC differed from human umbilical vein endothelila cells in that (1) maximal upregulation of ICAM-1 expression induced by IL-1beta or TNF-alpha required more time (2) TNF-alpha was more potent than IL-1beta in VCAM-1 expression, and (3) dexamethasone inhibited the upregulation of E-selectin expression alone.	Dexamethasone	239-252	interleukin 1 beta	Homo sapiens	124-132
9725242-9	1998	The down-regulatory effect of IFN-gamma on IL-1beta-induced COX-2 expression was abrogated with cycloheximide.	Cycloheximide	96-109	interleukin 1 beta	Homo sapiens	43-51
9737666-8	1998	Actinomycin D, cycloheximide, and brefeldin A inhibited the increase in DAF release induced by IL-4 and IL-1beta stimulation.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	104-112
9737666-8	1998	Actinomycin D, cycloheximide, and brefeldin A inhibited the increase in DAF release induced by IL-4 and IL-1beta stimulation.	Cycloheximide	15-28	interleukin 1 beta	Homo sapiens	104-112
9737666-8	1998	Actinomycin D, cycloheximide, and brefeldin A inhibited the increase in DAF release induced by IL-4 and IL-1beta stimulation.	Brefeldin A	34-45	interleukin 1 beta	Homo sapiens	104-112
9770325-2	1998	Since the precursor form of interleukin-1beta (pre-IL-1beta) is one of the well known substrates for ICE, and a potassium/proton ionophore, nigericin, enhances IL-1beta processing, the authors hypothesized that nigericin induces apoptosis through the activation of ICE.	Nigericin	140-149	interleukin 1 beta	Homo sapiens	51-59
9770325-2	1998	Since the precursor form of interleukin-1beta (pre-IL-1beta) is one of the well known substrates for ICE, and a potassium/proton ionophore, nigericin, enhances IL-1beta processing, the authors hypothesized that nigericin induces apoptosis through the activation of ICE.	Nigericin	140-149	interleukin 1 beta	Homo sapiens	160-168
9770325-2	1998	Since the precursor form of interleukin-1beta (pre-IL-1beta) is one of the well known substrates for ICE, and a potassium/proton ionophore, nigericin, enhances IL-1beta processing, the authors hypothesized that nigericin induces apoptosis through the activation of ICE.	Nigericin	211-220	interleukin 1 beta	Homo sapiens	28-45
9770325-4	1998	Under exactly the same conditions, nigericin also induced IL-1beta processing in these cells, which was significantly inhibited by an ICE inhibitor, acetyl-Tyr-Val-Ala-Asp-CHO.	Nigericin	35-44	interleukin 1 beta	Homo sapiens	58-66
9770325-4	1998	Under exactly the same conditions, nigericin also induced IL-1beta processing in these cells, which was significantly inhibited by an ICE inhibitor, acetyl-Tyr-Val-Ala-Asp-CHO.	L 709049	149-175	interleukin 1 beta	Homo sapiens	58-66
9768909-6	1998	The IL-1beta level was found to be higher in those with a TiAIV cemented prosthesis than in the control group (p=0.0001) and other groups of patients (p=0.003 v uncemented TiAIV, p=0.01 v cemented CrCoMo, p=0.001 v uncemented CrCoMo).	crcomo	197-203	interleukin 1 beta	Homo sapiens	4-12
9821108-3	1998	Combined treatment with IL-1 beta and IFN-gamma caused greater inhibition of TGF-beta secretion compared to treatment with IFN-gamma, and almost the same levels of inhibition as treatment with vincristine and etoposide.	Etoposide	209-218	interleukin 1 beta	Homo sapiens	24-33
10197168-0	1998	Matrix degradation by chondrocytes cultured in alginate: IL-1 beta induces proteoglycan degradation and proMMP synthesis but does not result in collagen degradation.	Alginates	47-55	interleukin 1 beta	Homo sapiens	57-66
10197168-5	1998	RESULTS: IL-1 beta induced a profound GAG release (approximately 80% after 2 days at 20 ng/ml IL-1 beta) that was both time and IL-1 beta concentration dependent.	Glycosaminoglycans	38-41	interleukin 1 beta	Homo sapiens	9-18
10197168-5	1998	RESULTS: IL-1 beta induced a profound GAG release (approximately 80% after 2 days at 20 ng/ml IL-1 beta) that was both time and IL-1 beta concentration dependent.	Glycosaminoglycans	38-41	interleukin 1 beta	Homo sapiens	94-103
10197168-5	1998	RESULTS: IL-1 beta induced a profound GAG release (approximately 80% after 2 days at 20 ng/ml IL-1 beta) that was both time and IL-1 beta concentration dependent.	Glycosaminoglycans	38-41	interleukin 1 beta	Homo sapiens	94-103
10197168-8	1998	After activation of the proMMPs by APMA, a time and IL-1 beta concentration-dependent increase in MMP-activity was found, which resulted in almost complete deterioration of collagen already after 18 h of incubation.	N-(3-Aminopropyl)methacrylamide	35-39	interleukin 1 beta	Homo sapiens	52-61
10197168-9	1998	In the presence of APMA, GAG release from IL-1 beta treated beads was significantly increased from 24 to 31%.	Glycosaminoglycans	25-28	interleukin 1 beta	Homo sapiens	42-51
9694725-4	1998	Band-shift assays were performed using the LPS-and IL-1-responsive element (LILRE) oligonucleotide, a gamma interferon activation site-like site that is present in the human IL-1beta promoter.	Oligonucleotides	83-98	interleukin 1 beta	Homo sapiens	174-182
9721692-11	1998	The concept that a high ratio of PGH2 was released by the IL-1beta-treated HUVECs and isomerized outside the cell into PGE2 and PGD2 was supported by the biosynthesis of thromboxane B2 by COX-inactivated platelets, indicating the uptake by platelets of HUVEC-derived PGH2.	Prostaglandin H2	33-37	interleukin 1 beta	Homo sapiens	58-66
9721692-11	1998	The concept that a high ratio of PGH2 was released by the IL-1beta-treated HUVECs and isomerized outside the cell into PGE2 and PGD2 was supported by the biosynthesis of thromboxane B2 by COX-inactivated platelets, indicating the uptake by platelets of HUVEC-derived PGH2.	Dinoprostone	119-123	interleukin 1 beta	Homo sapiens	58-66
9721692-11	1998	The concept that a high ratio of PGH2 was released by the IL-1beta-treated HUVECs and isomerized outside the cell into PGE2 and PGD2 was supported by the biosynthesis of thromboxane B2 by COX-inactivated platelets, indicating the uptake by platelets of HUVEC-derived PGH2.	Prostaglandin D2	128-132	interleukin 1 beta	Homo sapiens	58-66
9721692-11	1998	The concept that a high ratio of PGH2 was released by the IL-1beta-treated HUVECs and isomerized outside the cell into PGE2 and PGD2 was supported by the biosynthesis of thromboxane B2 by COX-inactivated platelets, indicating the uptake by platelets of HUVEC-derived PGH2.	Thromboxane B2	170-184	interleukin 1 beta	Homo sapiens	58-66
9721692-11	1998	The concept that a high ratio of PGH2 was released by the IL-1beta-treated HUVECs and isomerized outside the cell into PGE2 and PGD2 was supported by the biosynthesis of thromboxane B2 by COX-inactivated platelets, indicating the uptake by platelets of HUVEC-derived PGH2.	Prostaglandin H2	267-271	interleukin 1 beta	Homo sapiens	58-66
9721692-12	1998	The IL-1beta-induced increase in the release of PGH2 by HUVECs was suppressed by the COX-2-selective inhibitor SC-58125 and correlated with both COX-2 expression and PGIS inactivation.	Prostaglandin H2	48-52	interleukin 1 beta	Homo sapiens	4-12
9721692-12	1998	The IL-1beta-induced increase in the release of PGH2 by HUVECs was suppressed by the COX-2-selective inhibitor SC-58125 and correlated with both COX-2 expression and PGIS inactivation.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	111-119	interleukin 1 beta	Homo sapiens	4-12
9721692-13	1998	An approach to the mechanism of inactivation of PGIS by the exposure to IL-1beta was performed by using labeled endoperoxides as substrate.	endoperoxides	112-125	interleukin 1 beta	Homo sapiens	72-80
9721692-15	1998	in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees.	Deferoxamine	56-68	interleukin 1 beta	Homo sapiens	154-162
9721692-15	1998	in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees.	pyrrolidine dithiocarbamic acid	70-96	interleukin 1 beta	Homo sapiens	154-162
9721692-15	1998	in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees.	Dimethyl Sulfoxide	98-102	interleukin 1 beta	Homo sapiens	154-162
9721692-15	1998	in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees.	Mannitol	104-112	interleukin 1 beta	Homo sapiens	154-162
9721692-15	1998	in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees.	Captopril	118-127	interleukin 1 beta	Homo sapiens	154-162
9721692-16	1998	The NO synthase inhibitor NG-monomethyl-L-arginine also antagonized the PGIS inhibitory effect of IL-1beta, indicating that NO.	omega-N-Methylarginine	26-50	interleukin 1 beta	Homo sapiens	98-106
9721692-24	1998	to form NO2., dramatically potentiated the IL-1beta effect suggests that NO2.	Nitrogen Dioxide	8-11	interleukin 1 beta	Homo sapiens	43-51
9721692-24	1998	to form NO2., dramatically potentiated the IL-1beta effect suggests that NO2.	Nitrogen Dioxide	73-76	interleukin 1 beta	Homo sapiens	43-51
9744647-3	1998	After incubating 24 h, the combination of lipopolysaccharide and Fragmin induced significantly greater concentrations of interleukin 1 (IL)-1beta (25+/-10 ng/mL; x +/- standard error), IL-8 (21+/-6), and tumor necrosis factor (TNF)alpha (.48+/-.24) compared with heparinized blood (p &lt; .05).	Dalteparin	65-72	interleukin 1 beta	Homo sapiens	121-145
9744647-4	1998	The combination of Fragmin and zymosan also induced significantly greater concentrations of IL-1beta (97+/-24) and TNFalpha (2.9+/-.8), but not IL-8 (2.0+/-15).	Dalteparin	19-26	interleukin 1 beta	Homo sapiens	92-100
9744647-4	1998	The combination of Fragmin and zymosan also induced significantly greater concentrations of IL-1beta (97+/-24) and TNFalpha (2.9+/-.8), but not IL-8 (2.0+/-15).	Zymosan	31-38	interleukin 1 beta	Homo sapiens	92-100
9744647-5	1998	Average levels of proinflammatory cytokines (IL-1beta, IL-6, IL-8, and TNFalpha) were greater with Fragmin anticoagulation for 36 of 40 comparisons, and patterns were similar for 6 h and 24 h incubations.	Dalteparin	99-106	interleukin 1 beta	Homo sapiens	45-53
9721692-2	1998	Biosynthesis of eicosanoids in response to IL-1beta, exogenous labeled arachidonic acid (AA), or histamine, as well as their spontaneous release, was evaluated by means of HPLC and RIA.	Eicosanoids	16-27	interleukin 1 beta	Homo sapiens	43-51
9721692-3	1998	HUVECs exposed to IL-1beta produced prostaglandin (PG) I2 for no longer than 30 seconds after the substrate was added irrespective of the cyclooxygenase (COX) activity, whereas the time course of PGE2 and PGD2 formation was parallel to the COX activity.	Epoprostenol	36-57	interleukin 1 beta	Homo sapiens	18-26
9721692-3	1998	HUVECs exposed to IL-1beta produced prostaglandin (PG) I2 for no longer than 30 seconds after the substrate was added irrespective of the cyclooxygenase (COX) activity, whereas the time course of PGE2 and PGD2 formation was parallel to the COX activity.	Dinoprostone	196-200	interleukin 1 beta	Homo sapiens	18-26
9721692-3	1998	HUVECs exposed to IL-1beta produced prostaglandin (PG) I2 for no longer than 30 seconds after the substrate was added irrespective of the cyclooxygenase (COX) activity, whereas the time course of PGE2 and PGD2 formation was parallel to the COX activity.	Prostaglandin D2	205-209	interleukin 1 beta	Homo sapiens	18-26
9721692-6	1998	PGF2alpha was the main prostanoid released into the medium during exposure to IL-1beta, whereas when HUVECs treated with IL-1beta were stimulated with histamine or exogenous AA, PGE2 was released in a higher quantity than PGF2alpha.	Dinoprost	0-9	interleukin 1 beta	Homo sapiens	78-86
9721692-6	1998	PGF2alpha was the main prostanoid released into the medium during exposure to IL-1beta, whereas when HUVECs treated with IL-1beta were stimulated with histamine or exogenous AA, PGE2 was released in a higher quantity than PGF2alpha.	Prostaglandins	23-33	interleukin 1 beta	Homo sapiens	78-86
9721692-6	1998	PGF2alpha was the main prostanoid released into the medium during exposure to IL-1beta, whereas when HUVECs treated with IL-1beta were stimulated with histamine or exogenous AA, PGE2 was released in a higher quantity than PGF2alpha.	Histamine	151-160	interleukin 1 beta	Homo sapiens	121-129
9721692-6	1998	PGF2alpha was the main prostanoid released into the medium during exposure to IL-1beta, whereas when HUVECs treated with IL-1beta were stimulated with histamine or exogenous AA, PGE2 was released in a higher quantity than PGF2alpha.	Dinoprostone	178-182	interleukin 1 beta	Homo sapiens	121-129
9721692-6	1998	PGF2alpha was the main prostanoid released into the medium during exposure to IL-1beta, whereas when HUVECs treated with IL-1beta were stimulated with histamine or exogenous AA, PGE2 was released in a higher quantity than PGF2alpha.	Dinoprost	222-231	interleukin 1 beta	Homo sapiens	121-129
9721692-7	1998	PGF2alpha released into the medium during treatment with IL-1beta and the biosynthesis of PGE2 and PGD2 in response to exogenous AA or histamine increased with COX-2 expression, whereas this did not occur in the case of PGI2.	Dinoprost	0-9	interleukin 1 beta	Homo sapiens	57-65
9721692-7	1998	PGF2alpha released into the medium during treatment with IL-1beta and the biosynthesis of PGE2 and PGD2 in response to exogenous AA or histamine increased with COX-2 expression, whereas this did not occur in the case of PGI2.	Histamine	135-144	interleukin 1 beta	Homo sapiens	57-65
9770088-9	1998	Despite maintained expression of TNF and IL-1 beta mRNA-transcripts upon ex vivo LPS-stimulation in patients treated with GHB, release of the cytokines in the supernatant was decreased to a similar degree as in the control group.	Sodium Oxybate	122-125	interleukin 1 beta	Homo sapiens	41-50
9705828-6	1998	Inhibition of IL-1 beta induced COX-2 and elevated ICAM-1 expression, an effect reversed by exogenous PGE2.	Dinoprostone	102-106	interleukin 1 beta	Homo sapiens	14-23
9727639-4	1998	Furthermore, isolated blood monocytes collected 16 hr after alcohol consumption showed significantly decreased IL-1beta production in response to subsequent bacterial stimulation, implying that in vivo alcohol consumption affects monocyte-derived inflammatory cytokine production.	Alcohols	60-67	interleukin 1 beta	Homo sapiens	111-119
9727639-4	1998	Furthermore, isolated blood monocytes collected 16 hr after alcohol consumption showed significantly decreased IL-1beta production in response to subsequent bacterial stimulation, implying that in vivo alcohol consumption affects monocyte-derived inflammatory cytokine production.	Alcohols	202-209	interleukin 1 beta	Homo sapiens	111-119
9700093-1	1998	Interleukin (IL)-1beta impairs human airway smooth muscle (ASM) cell cAMP responses to isoproterenol (Iso).	Cyclic AMP	69-73	interleukin 1 beta	Homo sapiens	0-22
9700093-1	1998	Interleukin (IL)-1beta impairs human airway smooth muscle (ASM) cell cAMP responses to isoproterenol (Iso).	Isoproterenol	87-100	interleukin 1 beta	Homo sapiens	0-22
9700099-6	1998	Treatment with the transcriptional inhibitor actinomycin D before IL-1beta stimulation completely abolished induction of GM-CSF mRNA, whereas incubation with cycloheximide had no effect.	Dactinomycin	45-58	interleukin 1 beta	Homo sapiens	66-74
9700099-8	1998	Dexamethasone treatment of BEAS-2B cells produced an 80% inhibition of IL-1beta-induced GM-CSF protein and a 51% inhibition of GM-CSF mRNA.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	71-79
9770088-11	1998	In vitro, pharmacological doses of GHB-Na (2 mg/ml) attenuated LPS-induced IL-1 beta release.	ghb-na	35-41	interleukin 1 beta	Homo sapiens	75-84
9770088-12	1998	However, application of the GHB-receptor antagonist NCS-382 caused a nearly complete cessation of IL-1 beta release in vitro (to 2.5% of control).	NCS 382	52-59	interleukin 1 beta	Homo sapiens	98-107
9716178-3	1998	In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants.	Nitrates	210-217	interleukin 1 beta	Homo sapiens	81-98
9716178-3	1998	In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants.	Nitrites	222-229	interleukin 1 beta	Homo sapiens	81-98
9712106-0	1998	Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	27-44
9648917-0	1998	Dedifferentiated chondrocytes cultured in alginate beads: restoration of the differentiated phenotype and of the metabolic responses to interleukin-1beta.	Alginates	42-50	interleukin 1 beta	Homo sapiens	136-153
9648917-7	1998	Compared with cells in primary culture, the production of nitric oxide and 92-kDa gelatinase in response to interleukin-1beta was impaired in cells at passage 2 in monolayer but was fully recovered after their culture in alginate beads for 2 weeks.	Nitric Oxide	58-70	interleukin 1 beta	Homo sapiens	108-125
9648917-7	1998	Compared with cells in primary culture, the production of nitric oxide and 92-kDa gelatinase in response to interleukin-1beta was impaired in cells at passage 2 in monolayer but was fully recovered after their culture in alginate beads for 2 weeks.	Alginates	221-229	interleukin 1 beta	Homo sapiens	108-125
9648917-9	1998	This makes the culture in alginate beads a relevant model for the study of chondrocyte biology in the presence of interleukin-1beta and other mediators of cartilage destruction in rheumatoid arthritis and osteoarthrosis.	Alginates	26-34	interleukin 1 beta	Homo sapiens	114-131
9756187-4	1998	The production and release of pro-inflammatory cytokines are affected by theophylline showing a potent inhibitory effect on the production of IL-1beta, TNF-alpha and IFN-gamma.	Theophylline	73-85	interleukin 1 beta	Homo sapiens	142-150
9715267-1	1998	Regulation of P2X7 receptor expression is of interest because activation of this receptor by extracellular ATP triggers maturation and release of the pro-inflammatory cytokine interleukin-1 beta (IL-1 beta) in monocytes and macrophages.	Adenosine Triphosphate	107-110	interleukin 1 beta	Homo sapiens	176-194
9715267-1	1998	Regulation of P2X7 receptor expression is of interest because activation of this receptor by extracellular ATP triggers maturation and release of the pro-inflammatory cytokine interleukin-1 beta (IL-1 beta) in monocytes and macrophages.	Adenosine Triphosphate	107-110	interleukin 1 beta	Homo sapiens	196-205
9712106-0	1998	Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes.	Dinoprostone	83-99	interleukin 1 beta	Homo sapiens	46-54
9712106-9	1998	Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA.	omega-N-Methylarginine	58-82	interleukin 1 beta	Homo sapiens	167-175
9712106-9	1998	Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA.	omega-N-Methylarginine	58-82	interleukin 1 beta	Homo sapiens	263-271
9712106-0	1998	Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	46-54
9712106-9	1998	Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA.	omega-N-Methylarginine	84-90	interleukin 1 beta	Homo sapiens	167-175
9744517-7	1998	Several antiestrogens, H1285, ICI 182 780, and tamoxifen inhibited the estrogen stimulated enhancement of IL-1beta promoter activity in a dose-dependent manner, indicating that this effect was indeed mediated through the ER in a ligand dependent manner.	Tamoxifen	47-56	interleukin 1 beta	Homo sapiens	106-114
9712106-9	1998	Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA.	omega-N-Methylarginine	84-90	interleukin 1 beta	Homo sapiens	263-271
9712106-0	1998	Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes.	Dinoprostone	83-99	interleukin 1 beta	Homo sapiens	27-44
9712106-9	1998	Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA.	Dinoprostone	130-134	interleukin 1 beta	Homo sapiens	167-175
9746206-9	1998	Sphingomyelinase and interleukin-1beta, which are known to activate the sphingomyelin turnover leading to ceramide generation, also induced apoptosis mimicking the effects of ceramide.	Ceramides	106-114	interleukin 1 beta	Homo sapiens	21-38
9712106-10	1998	CONCLUSION: LPS and IL-1beta stimulated IL-6, IL-8, and PGE2 production are downregulated by endogenously produced NO, which could limit the inflammatory reaction occurring in arthritis.	Dinoprostone	56-60	interleukin 1 beta	Homo sapiens	20-28
10352496-0	1998	Inhibition by lysophosphatidylcholine of nitric oxide production in interleukin 1 beta-stimulated vascular smooth muscle cells.	Lysophosphatidylcholines	14-37	interleukin 1 beta	Homo sapiens	68-86
10352496-0	1998	Inhibition by lysophosphatidylcholine of nitric oxide production in interleukin 1 beta-stimulated vascular smooth muscle cells.	Nitric Oxide	41-53	interleukin 1 beta	Homo sapiens	68-86
10352496-1	1998	In vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 beta(IL-1 beta) stimulated nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS).	vsmc	33-37	interleukin 1 beta	Homo sapiens	71-89
10352496-1	1998	In vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 beta(IL-1 beta) stimulated nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS).	vsmc	33-37	interleukin 1 beta	Homo sapiens	90-99
10352496-1	1998	In vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 beta(IL-1 beta) stimulated nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS).	Nitric Oxide	112-124	interleukin 1 beta	Homo sapiens	71-89
10352496-1	1998	In vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 beta(IL-1 beta) stimulated nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS).	Nitric Oxide	112-124	interleukin 1 beta	Homo sapiens	90-99
10352496-5	1998	LPC by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose-dependently inhibited IL-1 beta-stimulated nitrite production.	Nitrites	138-145	interleukin 1 beta	Homo sapiens	117-126
9746206-9	1998	Sphingomyelinase and interleukin-1beta, which are known to activate the sphingomyelin turnover leading to ceramide generation, also induced apoptosis mimicking the effects of ceramide.	Ceramides	175-183	interleukin 1 beta	Homo sapiens	21-38
9990676-11	1998	IL-1 beta-stimulated PGE2 and PGE2 alpha formation was significantly decreased by both COX-1 and COX-2 inhibitors.	Dinoprostone	21-25	interleukin 1 beta	Homo sapiens	0-9
9990676-11	1998	IL-1 beta-stimulated PGE2 and PGE2 alpha formation was significantly decreased by both COX-1 and COX-2 inhibitors.	Dinoprostone	30-34	interleukin 1 beta	Homo sapiens	0-9
9990676-12	1998	VSA, in a dose-dependent manner, significantly decreased IL-1 beta-stimulated PGE2 and PGF2 alpha production.	Dinoprostone	78-82	interleukin 1 beta	Homo sapiens	57-66
9990676-12	1998	VSA, in a dose-dependent manner, significantly decreased IL-1 beta-stimulated PGE2 and PGF2 alpha production.	Dinoprost	87-91	interleukin 1 beta	Homo sapiens	57-66
9651388-0	1998	Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing.	Nigericin	84-93	interleukin 1 beta	Homo sapiens	17-34
9726641-1	1998	We studied the effect of the glucocorticoids, dexamethasone and budesonide, on the interleukin-1beta-induced increase of bradykinin B2 receptors in cultured human bronchial smooth muscle cells, a cellular model of bronchial hyperreactivity.	Dexamethasone	46-59	interleukin 1 beta	Homo sapiens	83-100
9726641-1	1998	We studied the effect of the glucocorticoids, dexamethasone and budesonide, on the interleukin-1beta-induced increase of bradykinin B2 receptors in cultured human bronchial smooth muscle cells, a cellular model of bronchial hyperreactivity.	Budesonide	64-74	interleukin 1 beta	Homo sapiens	83-100
9718981-0	1998	Acute effects of interleukin-1 beta on noradrenaline release from the human neuroblastoma cell line SH-SY5Y.	Norepinephrine	39-52	interleukin 1 beta	Homo sapiens	17-35
9873452-2	1998	Tripterine and closely related triterpenoid derivatives as IL-1 beta release inhibitors are discussed.	celastrol	0-10	interleukin 1 beta	Homo sapiens	59-68
9873452-2	1998	Tripterine and closely related triterpenoid derivatives as IL-1 beta release inhibitors are discussed.	triterpenoid TP-222	31-43	interleukin 1 beta	Homo sapiens	59-68
9651388-0	1998	Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing.	Nigericin	84-93	interleukin 1 beta	Homo sapiens	36-44
9651388-6	1998	Rapid secretion of mature, 17-kDa IL-1beta occurred, in the presence of nigericin (4-16 microM).	Nigericin	72-81	interleukin 1 beta	Homo sapiens	34-42
9651388-8	1998	Addition of the irreversible interleukin-1beta-converting enzyme (ICE) inhibitor, Z-Val-Ala-Asp-dichlorobenzoate, or a radicicol analog, inhibited nigericin-induced mature IL-1beta release and activation of p45 ICE precursor.	z-val-ala-asp-dichlorobenzoate	82-112	interleukin 1 beta	Homo sapiens	172-180
9651388-8	1998	Addition of the irreversible interleukin-1beta-converting enzyme (ICE) inhibitor, Z-Val-Ala-Asp-dichlorobenzoate, or a radicicol analog, inhibited nigericin-induced mature IL-1beta release and activation of p45 ICE precursor.	Nigericin	147-156	interleukin 1 beta	Homo sapiens	172-180
9651388-9	1998	The radicicol analog itself did not inhibit ICE, but markedly, and very rapidly depleted intracellular levels of 31-kDa proIL-1beta.	monorden	4-13	interleukin 1 beta	Homo sapiens	120-131
9651388-11	1998	We have therefore shown conclusively, for the first time, that nigericin-induced release of IL-1beta is dependent upon activation of p45 ICE processing.	Nigericin	63-72	interleukin 1 beta	Homo sapiens	92-100
9651388-12	1998	So far, the mechanism by which reduced intracellular potassium ion concentration triggers p45 ICE processing is not known, but further investigation in this area could lead to the discovery of novel molecular targets whereby control of IL-1beta production might be effected.	Potassium	53-62	interleukin 1 beta	Homo sapiens	236-244
9661009-3	1998	Trovafloxacin levels achievable in humans suppressed in vitro synthesis of each of the cytokines analyzed, viz., interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-6, IL-10, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha.	trovafloxacin	0-13	interleukin 1 beta	Homo sapiens	147-156
9704773-4	1998	Correlations were found between hyaluronic acid concentrations and interleukin-1beta (P = .018) and interleukin-8 (P = .003) concentrations in cervical mucus.	Hyaluronic Acid	32-47	interleukin 1 beta	Homo sapiens	67-84
9704780-1	1998	OBJECTIVE: The purpose of this study was to determine the inhibitory effects of anti-interleukin-1beta and transforming growth factor-beta2 on the production of interleukin-1beta and prostaglandin E2 by human decidual cells.	Dinoprostone	183-199	interleukin 1 beta	Homo sapiens	85-139
9704780-1	1998	OBJECTIVE: The purpose of this study was to determine the inhibitory effects of anti-interleukin-1beta and transforming growth factor-beta2 on the production of interleukin-1beta and prostaglandin E2 by human decidual cells.	Dinoprostone	183-199	interleukin 1 beta	Homo sapiens	85-102
9704780-8	1998	CONCLUSIONS: Lipopolysaccharide-induced prostaglandin E2 production by human decidual cells in vitro may be prevented by anti-interleukin-1beta and transforming growth factor-beta2, and interleukin-1beta production may be prevented by anti-interleukin-1beta.	Dinoprostone	40-56	interleukin 1 beta	Homo sapiens	126-180
9704780-8	1998	CONCLUSIONS: Lipopolysaccharide-induced prostaglandin E2 production by human decidual cells in vitro may be prevented by anti-interleukin-1beta and transforming growth factor-beta2, and interleukin-1beta production may be prevented by anti-interleukin-1beta.	Dinoprostone	40-56	interleukin 1 beta	Homo sapiens	126-143
9704780-8	1998	CONCLUSIONS: Lipopolysaccharide-induced prostaglandin E2 production by human decidual cells in vitro may be prevented by anti-interleukin-1beta and transforming growth factor-beta2, and interleukin-1beta production may be prevented by anti-interleukin-1beta.	Dinoprostone	40-56	interleukin 1 beta	Homo sapiens	186-203
9722717-21	1998	In addition, IL-1 is a strong enhancer of tissue levels of PGE2 and TNF-alpha.	Dinoprostone	59-63	interleukin 1 beta	Homo sapiens	13-17
9699892-5	1998	Expression of VCAM-1 in endothelial cells after exposure to tumour necrosis factor-alpha (TNF-alpha) or interleukin 1beta (IL-1beta) was quantified by ELISA and shown to be partially inhibited by 17beta-estradiol (40-60% inhibition) or by S-nitroso-L-glutathione, a nitric oxide donor (20-25%).	Estradiol	196-212	interleukin 1 beta	Homo sapiens	123-131
9699892-5	1998	Expression of VCAM-1 in endothelial cells after exposure to tumour necrosis factor-alpha (TNF-alpha) or interleukin 1beta (IL-1beta) was quantified by ELISA and shown to be partially inhibited by 17beta-estradiol (40-60% inhibition) or by S-nitroso-L-glutathione, a nitric oxide donor (20-25%).	S-Nitrosoglutathione	239-262	interleukin 1 beta	Homo sapiens	123-131
9699892-5	1998	Expression of VCAM-1 in endothelial cells after exposure to tumour necrosis factor-alpha (TNF-alpha) or interleukin 1beta (IL-1beta) was quantified by ELISA and shown to be partially inhibited by 17beta-estradiol (40-60% inhibition) or by S-nitroso-L-glutathione, a nitric oxide donor (20-25%).	Nitric Oxide	266-278	interleukin 1 beta	Homo sapiens	123-131
9645680-0	1998	The intracerebroventricular injection of interleukin-1beta blunts the testosterone response to human chorionic gonadotropin: role of prostaglandin- and adrenergic-dependent pathways.	Testosterone	70-82	interleukin 1 beta	Homo sapiens	41-58
9678051-7	1998	All particles induced the release of tumor necrosis factor and interleukin 1 beta; stainless steel particles were the most potent stimulators of interleukin 1 beta; titanium aluminum vanadium particles were the strongest stimulators of interleukin 6 and prostaglandin 2.	Stainless Steel	83-98	interleukin 1 beta	Homo sapiens	145-163
9645680-0	1998	The intracerebroventricular injection of interleukin-1beta blunts the testosterone response to human chorionic gonadotropin: role of prostaglandin- and adrenergic-dependent pathways.	Prostaglandins	133-146	interleukin 1 beta	Homo sapiens	41-58
9645680-2	1998	injection of interleukin-1beta(IL-1beta, 80 ng) significantly blunted the testosterone response to 1 U/kg human CG (hCG), an effect that we attributed to the stimulation of inhibitory pathways connecting the hypothalamus to the testes.	Testosterone	74-86	interleukin 1 beta	Homo sapiens	13-30
9645680-2	1998	injection of interleukin-1beta(IL-1beta, 80 ng) significantly blunted the testosterone response to 1 U/kg human CG (hCG), an effect that we attributed to the stimulation of inhibitory pathways connecting the hypothalamus to the testes.	Testosterone	74-86	interleukin 1 beta	Homo sapiens	31-39
9645680-2	1998	injection of interleukin-1beta(IL-1beta, 80 ng) significantly blunted the testosterone response to 1 U/kg human CG (hCG), an effect that we attributed to the stimulation of inhibitory pathways connecting the hypothalamus to the testes.	cysteinylglycine	112-114	interleukin 1 beta	Homo sapiens	13-30
9645680-2	1998	injection of interleukin-1beta(IL-1beta, 80 ng) significantly blunted the testosterone response to 1 U/kg human CG (hCG), an effect that we attributed to the stimulation of inhibitory pathways connecting the hypothalamus to the testes.	cysteinylglycine	112-114	interleukin 1 beta	Homo sapiens	31-39
9645680-7	1998	Finally, the central injection of the beta-adrenergic agonist isoproterenol, as well as that of norepinephrine, mimicked the ability of icv IL-1beta to blunt testicular secretory activity and produced a marked (P &lt; 0.01) decrease in the response to hCG within 5 min of their administration.	Isoproterenol	62-75	interleukin 1 beta	Homo sapiens	140-148
9645680-7	1998	Finally, the central injection of the beta-adrenergic agonist isoproterenol, as well as that of norepinephrine, mimicked the ability of icv IL-1beta to blunt testicular secretory activity and produced a marked (P &lt; 0.01) decrease in the response to hCG within 5 min of their administration.	Norepinephrine	96-110	interleukin 1 beta	Homo sapiens	140-148
9645680-9	1998	injection of IL-1beta activates a neural, catecholamine-dependent pathway that connects the brain and the testes independently of the pituitary.	Catecholamines	42-55	interleukin 1 beta	Homo sapiens	13-21
10070569-4	1998	Results showed that a 48 h O2 exposure was associated with two distinct patterns of response: a decrease in TNF-alpha, IL-1 beta and IL-6 expression, and an increase in IL-8.	Oxygen	27-29	interleukin 1 beta	Homo sapiens	119-128
9758209-1	1998	Interleukin-1beta (IL-1beta) stimulated PGE2 synthesis in human amnion derived WISH cells, whereas dexamethasone blocked IL-1beta-mediated stimulation of PGE2 production.	Dinoprostone	40-44	interleukin 1 beta	Homo sapiens	0-17
9758209-1	1998	Interleukin-1beta (IL-1beta) stimulated PGE2 synthesis in human amnion derived WISH cells, whereas dexamethasone blocked IL-1beta-mediated stimulation of PGE2 production.	Dinoprostone	40-44	interleukin 1 beta	Homo sapiens	19-27
9758209-1	1998	Interleukin-1beta (IL-1beta) stimulated PGE2 synthesis in human amnion derived WISH cells, whereas dexamethasone blocked IL-1beta-mediated stimulation of PGE2 production.	Dexamethasone	99-112	interleukin 1 beta	Homo sapiens	121-129
10505559-7	1998	Interleukin-1beta has a stimulating effect, which was synergistic with effluent dialysates, on the synthesis of HA by mesothelium and peritoneal fibroblasts.	Hyaluronic Acid	112-114	interleukin 1 beta	Homo sapiens	0-17
10070569-6	1998	We confirmed that a 48 h O2 exposure led to similar changes with a decrease in TNF-alpha, IL-1 beta and IL-6 production and an increase in IL-8.	Oxygen	25-27	interleukin 1 beta	Homo sapiens	90-99
9758209-1	1998	Interleukin-1beta (IL-1beta) stimulated PGE2 synthesis in human amnion derived WISH cells, whereas dexamethasone blocked IL-1beta-mediated stimulation of PGE2 production.	Dinoprostone	154-158	interleukin 1 beta	Homo sapiens	121-129
10070569-7	1998	Interestingly, this cytokine response was preceded during the first hours of O2 treatment by induction of TNF-alpha, IL-1 beta and IL-6.	Oxygen	77-79	interleukin 1 beta	Homo sapiens	117-126
9758209-5	1998	Dexamethasone treatment also decreased the IL-1beta mediated stimulation of the PGHS-2 native promoter but not the NF-kB mutant promoter.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	43-51
9688092-2	1998	We hypothesized that this phenomenon is self-limiting and that polymorphonuclear leukocyte (PMN)-derived reactive oxygen intermediates (ROI) might provide feedback regulation on the IL-1beta surface receptor (IL-1betaR)-G-protein-effector enzyme transducing tripartite complex that ultimately leads to NADPH oxidase activation.	Oxygen	114-120	interleukin 1 beta	Homo sapiens	182-190
9758209-7	1998	These results provide convincing evidence that NF-kB may mediate the IL-1beta stimulation of PGHS-2 gene expression as well as the dexamethasone inhibition of the IL-1beta induction process in WISH cells.	Dexamethasone	131-144	interleukin 1 beta	Homo sapiens	163-171
11061332-3	1998	The aim of the present study was to investigate the effect of glucose on unstimulated and lipopolysaccharide (LPS)-induced TNF and IL-1 production by human peripheral blood mononuclear cells (PBMC).	Glucose	62-69	interleukin 1 beta	Homo sapiens	131-135
9758210-0	1998	Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha.	Eicosanoids	0-10	interleukin 1 beta	Homo sapiens	87-96
9758210-1	1998	Interleukin-1beta (IL-1beta) and tumor necrosis factor (TNF alpha) induce prostanoid biosynthesis in vascular smooth muscle cells by promoting cyclooxygenase (COX) expression, but little is known about the biosynthesis of lipoxygenase (LPO) metabolites.	Prostaglandins	74-84	interleukin 1 beta	Homo sapiens	0-17
9758210-1	1998	Interleukin-1beta (IL-1beta) and tumor necrosis factor (TNF alpha) induce prostanoid biosynthesis in vascular smooth muscle cells by promoting cyclooxygenase (COX) expression, but little is known about the biosynthesis of lipoxygenase (LPO) metabolites.	Prostaglandins	74-84	interleukin 1 beta	Homo sapiens	19-27
9758210-2	1998	We investigated the effects of human recombinant IL-1beta and TNF alpha on the production of arachidonic acid (AA) metabolites by high-performance liquid chromatography (HPLC).	Arachidonic Acid	93-109	interleukin 1 beta	Homo sapiens	49-57
9758210-6	1998	HPASMC treated with 200 U/ml of IL-1beta and 500 U/ml of TNF alpha produced more COX metabolites such as 6-keto-PGF1alpha, thromboxane B2, PGF2alpha and PGE2 than control cells.	hpasmc	0-6	interleukin 1 beta	Homo sapiens	32-40
9758210-6	1998	HPASMC treated with 200 U/ml of IL-1beta and 500 U/ml of TNF alpha produced more COX metabolites such as 6-keto-PGF1alpha, thromboxane B2, PGF2alpha and PGE2 than control cells.	6-Ketoprostaglandin F1 alpha	105-121	interleukin 1 beta	Homo sapiens	32-40
9758210-6	1998	HPASMC treated with 200 U/ml of IL-1beta and 500 U/ml of TNF alpha produced more COX metabolites such as 6-keto-PGF1alpha, thromboxane B2, PGF2alpha and PGE2 than control cells.	Thromboxane B2	123-137	interleukin 1 beta	Homo sapiens	32-40
9758210-6	1998	HPASMC treated with 200 U/ml of IL-1beta and 500 U/ml of TNF alpha produced more COX metabolites such as 6-keto-PGF1alpha, thromboxane B2, PGF2alpha and PGE2 than control cells.	Dinoprost	139-148	interleukin 1 beta	Homo sapiens	32-40
9758210-6	1998	HPASMC treated with 200 U/ml of IL-1beta and 500 U/ml of TNF alpha produced more COX metabolites such as 6-keto-PGF1alpha, thromboxane B2, PGF2alpha and PGE2 than control cells.	Dinoprostone	153-157	interleukin 1 beta	Homo sapiens	32-40
9688092-2	1998	We hypothesized that this phenomenon is self-limiting and that polymorphonuclear leukocyte (PMN)-derived reactive oxygen intermediates (ROI) might provide feedback regulation on the IL-1beta surface receptor (IL-1betaR)-G-protein-effector enzyme transducing tripartite complex that ultimately leads to NADPH oxidase activation.	tripartite	258-268	interleukin 1 beta	Homo sapiens	182-190
9624172-6	1998	PD98059, a specific inhibitor of MAPK kinase activity, inhibited IL-1beta-induced LDL receptor expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Homo sapiens	65-73
9674568-1	1998	The modulation of intracellular Ca2+ concentration ([Ca2+]i) by the pro-inflammatory cytokine interleukin-1beta (IL-1beta) was assessed in synaptosomes loaded with the Ca2+-sensitive dye, Fura-2AM.	fura-2-am	188-196	interleukin 1 beta	Homo sapiens	94-111
9674568-1	1998	The modulation of intracellular Ca2+ concentration ([Ca2+]i) by the pro-inflammatory cytokine interleukin-1beta (IL-1beta) was assessed in synaptosomes loaded with the Ca2+-sensitive dye, Fura-2AM.	fura-2-am	188-196	interleukin 1 beta	Homo sapiens	113-121
9674568-2	1998	IL-1beta was found to exert a biphasic effect on the KCl-induced rise in [Ca2+]i, extending an inhibitory effect at lower (3.5 ng/ml) concentrations, and a stimulatory effect at high (100 ng/ml) concentrations.	Potassium Chloride	53-56	interleukin 1 beta	Homo sapiens	0-8
9674568-5	1998	We conclude that the biphasic actions of IL-1beta on the KCl-induced rise in [Ca2+]i are mediated through activation of alternative second messenger pathways.	Potassium Chloride	57-60	interleukin 1 beta	Homo sapiens	41-49
9624172-7	1998	In contrast, SB202190, a specific inhibitor of p38(MAPK), enhanced IL-1beta-induced LDL receptor expression, with a concomitant increase in ERK-1/2 activity.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	13-21	interleukin 1 beta	Homo sapiens	67-75
9624172-10	1998	These results show that IL-1beta- or TNF-induced LDL receptor expression requires ERK-1/2 activation, that the p38(MAPK) pathway negatively regulates LDL receptor expression, and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells.	Sterols	184-191	interleukin 1 beta	Homo sapiens	24-32
9650577-3	1998	Treatment of the cells with the A2A receptor agonist CGS 21680 inhibited both NO production and iNOS expression induced by stimulation with either LPS/IFN-gamma or TNF-alpha/IL-1beta, whereas the A1 and A3 receptor agonists, CPA and Cl-IB-MECA, respectively, did not have significant inhibitory effects.	cysteinylglycine	53-56	interleukin 1 beta	Homo sapiens	174-182
9637698-5	1998	In addition the proinflammatory cytokines IL-1beta and TNF-alpha produced increases in [3H]thymidine incorporation.	Tritium	88-90	interleukin 1 beta	Homo sapiens	42-50
9663558-0	1998	Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy.	Corticosterone	16-30	interleukin 1 beta	Homo sapiens	67-75
9637698-5	1998	In addition the proinflammatory cytokines IL-1beta and TNF-alpha produced increases in [3H]thymidine incorporation.	Thymidine	91-100	interleukin 1 beta	Homo sapiens	42-50
9637698-6	1998	IL-1beta and platelet-derived growth factor together produced an increase in [3H]thymidine greater than either agonist alone; this effect was not, however, seen when we examined changes in cell numbers.	3h]thymidine	78-90	interleukin 1 beta	Homo sapiens	0-8
9633934-5	1998	We present evidence that a proteasome inhibitor, N-acetyl-leucinyl-leucinyl-norleucinal (norLeu), and the protease inhibitor tosyl-Phe-chloromethylketone (TPCK) block IL-1beta induction of MCP-1 protein expression.	tosyl-phe-chloromethylketone	125-153	interleukin 1 beta	Homo sapiens	167-175
9690866-14	1998	The present experiments demonstrated that the release of PGE2 by astroglial cells pretreated with IL-1beta and TNF-alpha is due to enhanced COX-2 activity via activation of the L-arginine-NO pathway, and this may be relevant to the understanding of the pathophysiological mechanisms underlying neuroimmune disorders.	Dinoprostone	57-61	interleukin 1 beta	Homo sapiens	98-106
9690866-14	1998	The present experiments demonstrated that the release of PGE2 by astroglial cells pretreated with IL-1beta and TNF-alpha is due to enhanced COX-2 activity via activation of the L-arginine-NO pathway, and this may be relevant to the understanding of the pathophysiological mechanisms underlying neuroimmune disorders.	Arginine	177-187	interleukin 1 beta	Homo sapiens	98-106
9690866-2	1998	The role of the L-arginine-nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) was investigated.	Arginine	16-26	interleukin 1 beta	Homo sapiens	147-164
9632533-6	1998	22Na+ and 36Cl- fluxes were not altered and residual flux increased by 2.4+/-1.0 micromol.h-1.cm-2 indicating that the IL-1beta-induced ISC is based on electrogenic bicarbonate secretion.	Bicarbonates	165-176	interleukin 1 beta	Homo sapiens	119-127
9690866-2	1998	The role of the L-arginine-nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) was investigated.	Dinoprostone	73-89	interleukin 1 beta	Homo sapiens	147-164
9690866-2	1998	The role of the L-arginine-nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) was investigated.	Dinoprostone	73-89	interleukin 1 beta	Homo sapiens	166-174
9690866-2	1998	The role of the L-arginine-nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) was investigated.	Dinoprostone	91-95	interleukin 1 beta	Homo sapiens	147-164
9690866-6	1998	The latter effect showed that the enhanced arachidonic acid (AA) metabolism subsequent to stimulation of astroglial cells with IL-1beta and TNF-alpha was, at least in part, induced by NO.	Arachidonic Acid	43-59	interleukin 1 beta	Homo sapiens	127-135
9632533-9	1998	While tetrodotoxin and the 5-lipoxygenase inhibitor ICI-230487 had no effect, indomethacin completely blocked IL-1beta action.	Indomethacin	78-90	interleukin 1 beta	Homo sapiens	110-118
9683032-12	1998	CONCLUSIONS: These studies identify requirements for selectins, beta2 integrins, IL-1 and a rat chemokine(s) similar to human IL-8 for neutrophil recruitment during glycogen-induced peritonitis.	Glycogen	165-173	interleukin 1 beta	Homo sapiens	81-85
9678530-3	1998	In GHD children, serum TNF-alpha and IL-1beta values had significantly increased (P &lt; 0.002) 4h (26.75 +/- 5.57 pg/ml and 2.99 +/- 0.21 ng/ml respectively) and decreased again 24 h after GH administration.	4h	96-98	interleukin 1 beta	Homo sapiens	37-45
10684020-2	1998	Interleukin 1 beta converting enzyme(ICE) expression and Fas expression in early pregnant villi and their changes following mifepristone administration were detected by immunohistochmical method and computer image analysis.	Mifepristone	124-136	interleukin 1 beta	Homo sapiens	0-18
10330521-6	1998	At the age of seven months the stimulated CS levels induced by an acute stress (novel environment) were lower in rats treated neonatally with IL-1 than in controls (P&lt;0.01).	Corticosterone	42-44	interleukin 1 beta	Homo sapiens	142-146
9879973-3	1998	Whole bacterial cells and isolated PG from these strains, grown in the presence of oxacillin, showed a significantly reduced stimulation of tumour necrosis factor-alpha, interleukin (IL)-1beta and IL-6 release by human monocytes in a concentration-dependent fashion.	Oxacillin	83-92	interleukin 1 beta	Homo sapiens	170-192
9741345-3	1998	The effect of bacterial endotoxin, interleukin-1 beta (IL-1 beta), fatty acids and prostaglandin E2 (PGE2) on the phagocytosis of fluoroscein isothiocyanate (FITC)-labelled Escherichia coli (O157) by human blood monocytes and U937 cells was studied by flow cytometry.	fluoroscein isothiocyanate	130-156	interleukin 1 beta	Homo sapiens	55-64
9741345-5	1998	IL-1 beta and the polyunsaturated fatty acids; dihomo-gamma-linolenic and arachidonic acids also increased the phagocytic activity of both monocytes and U937 cells.	Arachidonic Acids	74-91	interleukin 1 beta	Homo sapiens	0-9
9741345-9	1998	Endotoxin and fatty acids increased IL-1 beta release also, whereas PGE2 inhibited release.	Fatty Acids	14-25	interleukin 1 beta	Homo sapiens	36-45
9660250-0	1998	Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes.	Serotonin	0-9	interleukin 1 beta	Homo sapiens	98-106
9660250-0	1998	Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes.	N-(p-coumaroyl)serotonin	22-47	interleukin 1 beta	Homo sapiens	98-106
9660250-4	1998	ELISA assay revealed that the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 was inhibited by CS.	N-(p-coumaroyl)serotonin	102-104	interleukin 1 beta	Homo sapiens	66-74
9693584-3	1998	IL-1 beta inhibited pulp cell proliferation, but this effect was decreased by the presence of indomethacin.	Indomethacin	94-106	interleukin 1 beta	Homo sapiens	0-9
9693584-6	1998	IL-1 beta stimulated synthesis of type I collagen both in the absence and presence of indomethacin.	Indomethacin	86-98	interleukin 1 beta	Homo sapiens	0-9
9693584-7	1998	Results suggest that the inhibitory effect on pulp cell proliferation is dependent upon IL-1 beta-induced prostaglandin E2 synthesis and that IL-1 beta is a potent mediator of prostaglandin E2 synthesis in dental pulp.	Dinoprostone	106-122	interleukin 1 beta	Homo sapiens	88-97
9693584-7	1998	Results suggest that the inhibitory effect on pulp cell proliferation is dependent upon IL-1 beta-induced prostaglandin E2 synthesis and that IL-1 beta is a potent mediator of prostaglandin E2 synthesis in dental pulp.	Dinoprostone	176-192	interleukin 1 beta	Homo sapiens	142-151
9641167-8	1998	CONCLUSION: TNF alpha, TGF beta, PDGF and IL-1beta increased LDLr gene expression by increasing sterol-independent and mitogenesis-independent gene transcription.	Sterols	96-102	interleukin 1 beta	Homo sapiens	42-50
9614202-0	1998	Interleukin-1beta induces bradykinin B2 receptor gene expression through a prostanoid cyclic AMP-dependent pathway in human bronchial smooth muscle cells.	prostanoid cyclic amp	75-96	interleukin 1 beta	Homo sapiens	0-17
9614202-5	1998	These effects of IL-1beta were largely inhibited by indomethacin, suggesting the involvement of a prostanoid pathway in IL-1beta transduction process.	Indomethacin	52-64	interleukin 1 beta	Homo sapiens	17-25
9614202-5	1998	These effects of IL-1beta were largely inhibited by indomethacin, suggesting the involvement of a prostanoid pathway in IL-1beta transduction process.	Indomethacin	52-64	interleukin 1 beta	Homo sapiens	120-128
9614202-5	1998	These effects of IL-1beta were largely inhibited by indomethacin, suggesting the involvement of a prostanoid pathway in IL-1beta transduction process.	Prostaglandins	98-108	interleukin 1 beta	Homo sapiens	17-25
9614202-5	1998	These effects of IL-1beta were largely inhibited by indomethacin, suggesting the involvement of a prostanoid pathway in IL-1beta transduction process.	Prostaglandins	98-108	interleukin 1 beta	Homo sapiens	120-128
9614202-7	1998	Moreover, IL-1beta and prostaglandin E2 led to cAMP formation.	Cyclic AMP	47-51	interleukin 1 beta	Homo sapiens	10-18
9625031-6	1998	RESULTS: An interesting effect on proinflammatory monokines was observed: in this study, we demonstrate that the calcium antagonist diltiazem enhances interleukin-1beta and slightly reduces interleukin-6 production in MLC, but it has no effect on tumor necrosis factor-alpha levels.	Calcium	113-120	interleukin 1 beta	Homo sapiens	151-168
9665590-3	1998	NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate, a known inhibitor of NF-kappaB activation, blocked LPS- and IL-1beta-induced IL-8 production.	pyrrolidine dithiocarbamic acid	56-82	interleukin 1 beta	Homo sapiens	144-152
9626293-13	1998	The levels of IL-1 beta-induced nitric oxide production did not differ between moyamoya SMCs and control SMCs, suggesting that IL-1 beta inhibits the migration of moyamoya SMCs through a nitric oxide-independent pathway.	Nitric Oxide	32-44	interleukin 1 beta	Homo sapiens	14-23
9626293-13	1998	The levels of IL-1 beta-induced nitric oxide production did not differ between moyamoya SMCs and control SMCs, suggesting that IL-1 beta inhibits the migration of moyamoya SMCs through a nitric oxide-independent pathway.	Nitric Oxide	187-199	interleukin 1 beta	Homo sapiens	127-136
9625031-6	1998	RESULTS: An interesting effect on proinflammatory monokines was observed: in this study, we demonstrate that the calcium antagonist diltiazem enhances interleukin-1beta and slightly reduces interleukin-6 production in MLC, but it has no effect on tumor necrosis factor-alpha levels.	Diltiazem	132-141	interleukin 1 beta	Homo sapiens	151-168
9582321-2	1998	Previously we reported that interleukin-1beta induces activation of JNK/SAPK and p38 MAPK with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 (PGE2) synthesis.	Dinoprostone	162-178	interleukin 1 beta	Homo sapiens	28-45
9631139-5	1998	DESIGN AND METHODS: Linomide inhibits production of proinflammatory cytokines such as TNF-alpha, interleukin-1 beta and IFN-gamma, as well as iNOS synthesis.	roquinimex	20-28	interleukin 1 beta	Homo sapiens	97-115
9582321-2	1998	Previously we reported that interleukin-1beta induces activation of JNK/SAPK and p38 MAPK with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 (PGE2) synthesis.	Dinoprostone	180-184	interleukin 1 beta	Homo sapiens	28-45
9652398-9	1998	However, in these cells, IL-1beta induction of inducible nitric oxide synthase, granulocyte-macrophage colony stimulating factor and cyclooxygenase-2 mRNA showed 70-90% repression by dexamethsone.	dexamethsone	183-195	interleukin 1 beta	Homo sapiens	25-33
9633531-1	1998	In the present studies we found that incubation of human lung fibroblasts with transforming growth factor-beta 1 (TGF-beta 1) potentiated the interleukin-1 beta (IL-1 beta) and/or tumor necrosis factor-alpha (TNF-alpha)-stimulated production of prostaglandin E2 (PGE2).	Dinoprostone	245-261	interleukin 1 beta	Homo sapiens	142-160
9633531-1	1998	In the present studies we found that incubation of human lung fibroblasts with transforming growth factor-beta 1 (TGF-beta 1) potentiated the interleukin-1 beta (IL-1 beta) and/or tumor necrosis factor-alpha (TNF-alpha)-stimulated production of prostaglandin E2 (PGE2).	Dinoprostone	263-267	interleukin 1 beta	Homo sapiens	142-160
9633531-9	1998	In summary, we demonstrate that the potentiation of PGE2 production by TGF-beta 1 in IL-1 beta and TNF-alpha-treated fibroblasts is the result of transcriptional stimulation of the Cox-2 gene by IL-1 beta and TNF-alpha and the stabilization of the resulting transcripts by TGF-beta 1.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	85-94
9633531-9	1998	In summary, we demonstrate that the potentiation of PGE2 production by TGF-beta 1 in IL-1 beta and TNF-alpha-treated fibroblasts is the result of transcriptional stimulation of the Cox-2 gene by IL-1 beta and TNF-alpha and the stabilization of the resulting transcripts by TGF-beta 1.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	195-204
9593764-10	1998	This correlation was further confirmed by reporter gene assays which showed that this NF-kappaB-like sequence, in the B1-receptor promoter context, could contribute to IL-1beta and DLBK-induced B1-receptor transcription activation, and by the effect of NF-kappaB inhibitor pyrrolidinedithiocarbamate which diminished both B1-receptor upregulation and NF-kappaB activation.	pyrrolidine dithiocarbamic acid	273-299	interleukin 1 beta	Homo sapiens	168-176
9652398-0	1998	Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells.	Dexamethasone	10-23	interleukin 1 beta	Homo sapiens	27-44
9652398-0	1998	Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells.	Dexamethasone	10-23	interleukin 1 beta	Homo sapiens	46-54
9652398-8	1998	Stable transfection of a kappaB-dependent reporter in A549 cells resulted in an 8-9-fold activation by IL-1beta or phorbol ester, that was repressed 30-40% by dexamethasone.	Dexamethasone	159-172	interleukin 1 beta	Homo sapiens	103-111
9652398-11	1998	Furthermore, since the maximal repression of IL-1beta or phorbol-ester-induced kappaB-dependent transcription by dexamethasone was less than 40%, simple inhibition of kappaB-dependent transcription cannot by itself account for the full repressive effects of glucocorticoids observed in these cells.	Dexamethasone	113-126	interleukin 1 beta	Homo sapiens	45-53
9659298-1	1998	Fetal membranes from term human pregnancies produce prostaglandins, and may respond to bacterial endotoxin or interleukin-1 beta (IL-1 beta) with increased prostaglandin E2 (PGE2) production.	Dinoprostone	174-178	interleukin 1 beta	Homo sapiens	130-139
9629257-4	1998	IL-1 beta activates afferent vagal fibers that terminate in the nucleus tractus solitarius, and communication via the vagus is responsible for much of the hyperalgesia, fever, anorexia, taste aversions, increased levels of plasma corticosteroid, and brain norepinephrine changes produced by intraperitoneal injections of IL-1 beta and LPS.	Norepinephrine	256-270	interleukin 1 beta	Homo sapiens	0-9
9629269-9	1998	IL-1 beta increased the concentration of norepinephrine in the KAT45 culture medium from 24.2 +/- 3.5 micrograms/mg protein (n = 6 controls, at 24 hours), to 33.2 +/- 3.5 (IL-1 beta 10 mg/ml) or to 42.9 +/- 8 (IL-1 beta 30 mg/ml).	Norepinephrine	41-55	interleukin 1 beta	Homo sapiens	0-9
9629269-9	1998	IL-1 beta increased the concentration of norepinephrine in the KAT45 culture medium from 24.2 +/- 3.5 micrograms/mg protein (n = 6 controls, at 24 hours), to 33.2 +/- 3.5 (IL-1 beta 10 mg/ml) or to 42.9 +/- 8 (IL-1 beta 30 mg/ml).	kat45 culture medium	63-83	interleukin 1 beta	Homo sapiens	0-9
9672141-0	1998	Influence of L-glutamic acid on binding of interleukin-1beta, tumour necrosis factor-alpha and interleukin-6 to HL-60 cells.	Glutamic Acid	13-28	interleukin 1 beta	Homo sapiens	43-90
9672141-4	1998	Thus, L-Glu decreases the sensitivity of the HL-60 cells to IL-1beta and IL-6 and increases TNF-alpha binding at concentration 0.1 microM.	Glutamic Acid	6-11	interleukin 1 beta	Homo sapiens	60-68
9659298-1	1998	Fetal membranes from term human pregnancies produce prostaglandins, and may respond to bacterial endotoxin or interleukin-1 beta (IL-1 beta) with increased prostaglandin E2 (PGE2) production.	Dinoprostone	156-172	interleukin 1 beta	Homo sapiens	110-128
9659298-1	1998	Fetal membranes from term human pregnancies produce prostaglandins, and may respond to bacterial endotoxin or interleukin-1 beta (IL-1 beta) with increased prostaglandin E2 (PGE2) production.	Dinoprostone	156-172	interleukin 1 beta	Homo sapiens	130-139
9605977-5	1998	In the human pro-monocytic cell line THP-1, okadaic acid increased mRNA accumulation and synthesis of IL-1beta protein.	Okadaic Acid	44-56	interleukin 1 beta	Homo sapiens	102-110
9605977-7	1998	Okadaic acid stabilization of IL-1beta mRNA appears to be the primary mechanism through which endotoxin-tolerant cells accumulate IL-1beta mRNA and protein.	Okadaic Acid	0-12	interleukin 1 beta	Homo sapiens	30-38
9605977-7	1998	Okadaic acid stabilization of IL-1beta mRNA appears to be the primary mechanism through which endotoxin-tolerant cells accumulate IL-1beta mRNA and protein.	Okadaic Acid	0-12	interleukin 1 beta	Homo sapiens	130-138
9605977-9	1998	However, the transcription factor NF-kappaB, which is known to be involved in IL-1beta expression, was translocated to the nucleus in both normal and endotoxin-tolerant cells after treatment with okadaic acid.	Okadaic Acid	196-208	interleukin 1 beta	Homo sapiens	78-86
9593038-3	1998	The combination of GBS and lactate also enhanced the secretion of interleukin (IL)-1beta and IL-6.	gbs	19-22	interleukin 1 beta	Homo sapiens	66-88
9593038-3	1998	The combination of GBS and lactate also enhanced the secretion of interleukin (IL)-1beta and IL-6.	Lactic Acid	27-34	interleukin 1 beta	Homo sapiens	66-88
9610777-6	1998	The ability of cAMP derivatives and rolipram to block the induction of TNF-alpha and IL-1beta in astrocytes and microglia and to normalize the fatty acid pathogen in skin fibroblasts of x-adrenoleukodystrophy (X-ALD) clearly identify cAMP analogs or rolipram as candidates for potential therapy for X-ALD patients.	Cyclic AMP	15-19	interleukin 1 beta	Homo sapiens	85-93
9610777-6	1998	The ability of cAMP derivatives and rolipram to block the induction of TNF-alpha and IL-1beta in astrocytes and microglia and to normalize the fatty acid pathogen in skin fibroblasts of x-adrenoleukodystrophy (X-ALD) clearly identify cAMP analogs or rolipram as candidates for potential therapy for X-ALD patients.	Rolipram	36-44	interleukin 1 beta	Homo sapiens	85-93
9659298-8	1998	Both endotoxin and IL-1 beta increased PGE2 production from the activated aspirin-pretreated membranes during this culture time, but this was transient as after 12 h of culture basal PGE2 production rose to over 200 pg/ml despite aspirin pretreatment.	Dinoprostone	39-43	interleukin 1 beta	Homo sapiens	19-28
9659298-8	1998	Both endotoxin and IL-1 beta increased PGE2 production from the activated aspirin-pretreated membranes during this culture time, but this was transient as after 12 h of culture basal PGE2 production rose to over 200 pg/ml despite aspirin pretreatment.	Aspirin	74-81	interleukin 1 beta	Homo sapiens	19-28
9659298-8	1998	Both endotoxin and IL-1 beta increased PGE2 production from the activated aspirin-pretreated membranes during this culture time, but this was transient as after 12 h of culture basal PGE2 production rose to over 200 pg/ml despite aspirin pretreatment.	Dinoprostone	183-187	interleukin 1 beta	Homo sapiens	19-28
9659298-8	1998	Both endotoxin and IL-1 beta increased PGE2 production from the activated aspirin-pretreated membranes during this culture time, but this was transient as after 12 h of culture basal PGE2 production rose to over 200 pg/ml despite aspirin pretreatment.	Aspirin	230-237	interleukin 1 beta	Homo sapiens	19-28
9581775-5	1998	Inhibition of TNFalpha-induced NF-kappaB activation using the antioxidant N-acetylcysteine (NAC) resulted in increased apoptosis in both U937 and U9-IIIB cells, while preactivation of NF-kappaB with the non-apoptotic inducer IL-1beta caused a relative decrease in apoptosis.	Acetylcysteine	74-90	interleukin 1 beta	Homo sapiens	225-233
9705080-8	1998	The apparent Km and Vmax estimated by the release of [3H]water was 5.8+/-0.6 nM and 10.8+/-1.4 pmol/mg per 6 h in the presence of DEX + IL-1beta.	Tritium	54-56	interleukin 1 beta	Homo sapiens	136-144
9705080-8	1998	The apparent Km and Vmax estimated by the release of [3H]water was 5.8+/-0.6 nM and 10.8+/-1.4 pmol/mg per 6 h in the presence of DEX + IL-1beta.	Water	57-62	interleukin 1 beta	Homo sapiens	136-144
9705080-8	1998	The apparent Km and Vmax estimated by the release of [3H]water was 5.8+/-0.6 nM and 10.8+/-1.4 pmol/mg per 6 h in the presence of DEX + IL-1beta.	Dexamethasone	130-133	interleukin 1 beta	Homo sapiens	136-144
9682786-5	1998	IL-1 beta decreased PG and coll-II productions and increased PGE2 synthesis.	Dinoprostone	61-65	interleukin 1 beta	Homo sapiens	0-9
9682786-6	1998	During the first period (0-16 days), while the cluster is forming, ACS counteracted the IL-1 beta-induced effects on PG (500-1000 micrograms ACS/ml), coll-II (100-1000 micrograms ACS/ml) and PGE2 (500-1000 micrograms ACS/ml) productions.	Dinoprostone	191-195	interleukin 1 beta	Homo sapiens	88-97
9682786-7	1998	During the second period (16-32 days), when the cluster is already formed, ACS counteracted the IL-1 beta-induced effects on total PG (100-1000 micrograms ACS/ml), coll-II (1000 micrograms ACS/ml) and PGE2 (1000 micrograms ACS/ml) productions.	Dinoprostone	201-205	interleukin 1 beta	Homo sapiens	96-105
9581775-5	1998	Inhibition of TNFalpha-induced NF-kappaB activation using the antioxidant N-acetylcysteine (NAC) resulted in increased apoptosis in both U937 and U9-IIIB cells, while preactivation of NF-kappaB with the non-apoptotic inducer IL-1beta caused a relative decrease in apoptosis.	Acetylcysteine	92-95	interleukin 1 beta	Homo sapiens	225-233
9571196-5	1998	Among various potential stimulants tested, interleukin-1 beta (IL-1 beta) dramatically increased PGE2 production and significantly stimulated HGF production.	Dinoprostone	97-101	interleukin 1 beta	Homo sapiens	43-61
9545260-5	1998	Cell stresses such as arsenite and anisomycin and the cytokines tumor necrosis factor-alpha and interleukin-1beta also cause increased phosphorylation of eIF4E, which is abolished by the specific p38 MAP kinase inhibitor, SB203580.	arsenite	22-30	interleukin 1 beta	Homo sapiens	96-113
9545260-5	1998	Cell stresses such as arsenite and anisomycin and the cytokines tumor necrosis factor-alpha and interleukin-1beta also cause increased phosphorylation of eIF4E, which is abolished by the specific p38 MAP kinase inhibitor, SB203580.	Anisomycin	35-45	interleukin 1 beta	Homo sapiens	96-113
9545260-5	1998	Cell stresses such as arsenite and anisomycin and the cytokines tumor necrosis factor-alpha and interleukin-1beta also cause increased phosphorylation of eIF4E, which is abolished by the specific p38 MAP kinase inhibitor, SB203580.	SB 203580	222-230	interleukin 1 beta	Homo sapiens	96-113
9571196-5	1998	Among various potential stimulants tested, interleukin-1 beta (IL-1 beta) dramatically increased PGE2 production and significantly stimulated HGF production.	Dinoprostone	97-101	interleukin 1 beta	Homo sapiens	63-72
9571196-7	1998	IND significantly reduced both basal and IL-1 beta-induced PGE2 release and HGF production.	Indomethacin	0-3	interleukin 1 beta	Homo sapiens	41-50
9571196-7	1998	IND significantly reduced both basal and IL-1 beta-induced PGE2 release and HGF production.	Dinoprostone	59-63	interleukin 1 beta	Homo sapiens	41-50
9525952-6	1998	Tumor necrosis factor-alpha and IL-1alpha also elevated VEGF-C mRNA steady-state levels, whereas the IL-1 receptor antagonist and dexamethasone inhibited the effect of IL-1beta.	Dexamethasone	130-143	interleukin 1 beta	Homo sapiens	168-176
9525952-7	1998	Experiments with cycloheximide indicated that the effect of IL-1beta was independent of protein synthesis.	Cycloheximide	17-30	interleukin 1 beta	Homo sapiens	60-68
9575969-3	1998	Chloroquine revealed a dose-dependent inhibitory effect on endotoxin-induced secretion of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 that was associated with reduced cytokine mRNA expression.	Chloroquine	0-11	interleukin 1 beta	Homo sapiens	119-137
9575890-0	1998	IGF-I and insulin amplify IL-1 beta-induced nitric oxide and prostaglandin biosynthesis.	Nitric Oxide	44-56	interleukin 1 beta	Homo sapiens	26-35
9575890-0	1998	IGF-I and insulin amplify IL-1 beta-induced nitric oxide and prostaglandin biosynthesis.	Prostaglandins	61-74	interleukin 1 beta	Homo sapiens	26-35
9575890-1	1998	The inflammatory cytokine interleukin-1 beta (IL-1 beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric oxide synthase (iNOS) with concomitant release of PGs and nitric oxide (NO) by glomerular mesangial cells.	Phosphatidylglycerols	170-173	interleukin 1 beta	Homo sapiens	26-44
9575890-1	1998	The inflammatory cytokine interleukin-1 beta (IL-1 beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric oxide synthase (iNOS) with concomitant release of PGs and nitric oxide (NO) by glomerular mesangial cells.	Phosphatidylglycerols	170-173	interleukin 1 beta	Homo sapiens	46-55
9575890-1	1998	The inflammatory cytokine interleukin-1 beta (IL-1 beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric oxide synthase (iNOS) with concomitant release of PGs and nitric oxide (NO) by glomerular mesangial cells.	Nitric Oxide	113-125	interleukin 1 beta	Homo sapiens	26-44
9575890-1	1998	The inflammatory cytokine interleukin-1 beta (IL-1 beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric oxide synthase (iNOS) with concomitant release of PGs and nitric oxide (NO) by glomerular mesangial cells.	Nitric Oxide	113-125	interleukin 1 beta	Homo sapiens	46-55
9839700-6	1998	BK</protein-id> and IL-1 beta both significantly stimulated the release of [3H]arachidonic acid.	[3h]arachidonic acid	75-95	interleukin 1 beta	Homo sapiens	20-29
9839700-8	1998	These data suggest that the synergistic effect of BK and IL-1 beta on prostanoid biosynthesis is not due to interactions at the receptor level nor to enhanced release of arachidonic acid, but may be due to increased activity of cyclo-oxygenase.	Prostaglandins	70-80	interleukin 1 beta	Homo sapiens	57-66
9839700-8	1998	These data suggest that the synergistic effect of BK and IL-1 beta on prostanoid biosynthesis is not due to interactions at the receptor level nor to enhanced release of arachidonic acid, but may be due to increased activity of cyclo-oxygenase.	Arachidonic Acid	170-186	interleukin 1 beta	Homo sapiens	57-66
9516157-4	1998	After activation of the IC-bearing endothelial layers with interleukin-1 (IL-1) or tumor necrosis factor (TNF), or both, for 4 hours, rolling adhesion of the neutrophils was induced, accompanied by considerable H2O2 production.	Hydrogen Peroxide	211-215	interleukin 1 beta	Homo sapiens	24-72
9516157-4	1998	After activation of the IC-bearing endothelial layers with interleukin-1 (IL-1) or tumor necrosis factor (TNF), or both, for 4 hours, rolling adhesion of the neutrophils was induced, accompanied by considerable H2O2 production.	Hydrogen Peroxide	211-215	interleukin 1 beta	Homo sapiens	74-78
9558006-4	1998	Here, we present research examining paclitaxel"s ability to alter expression of the interleukin-1beta (IL-1beta) and IL-8 cytokines in primary human monocytes, T lymphocytes, and four human breast cancer cell lines: MCF-7, ZR-75-1, MDA-MB-468, and MDA-MB-231.	Paclitaxel	36-46	interleukin 1 beta	Homo sapiens	84-101
9558006-4	1998	Here, we present research examining paclitaxel"s ability to alter expression of the interleukin-1beta (IL-1beta) and IL-8 cytokines in primary human monocytes, T lymphocytes, and four human breast cancer cell lines: MCF-7, ZR-75-1, MDA-MB-468, and MDA-MB-231.	Paclitaxel	36-46	interleukin 1 beta	Homo sapiens	103-111
9558006-5	1998	This report shows for the first time that treatment with 5-50 microM paclitaxel increases steady-state levels of IL-1beta mRNA in unprimed human monocytes, MCF-7, and ZR-75-1 cells.	Paclitaxel	69-79	interleukin 1 beta	Homo sapiens	113-121
9575890-2	1998	In our current studies, we determine whether insulin and IGF-I are involved in the signal transduction mechanisms resulting in IL-1 beta-induced NO and PGE2 biosynthesis in renal mesangial cells.	Dinoprostone	152-156	interleukin 1 beta	Homo sapiens	127-136
9575890-3	1998	We demonstrate that both insulin and IGF-I increase IL-1 beta-induced Cox-2 and iNOS protein expression, which in turn enhance PGE2 and NO production.	Dinoprostone	127-131	interleukin 1 beta	Homo sapiens	52-61
9622278-0	1998	Lysophosphatidylcholine induces the production of IL-1beta by human monocytes.	Lysophosphatidylcholines	0-23	interleukin 1 beta	Homo sapiens	50-58
9584910-6	1998	The finding that triclosan reduces the production of the inflammatory mediator IL-1beta in gingival fibroblasts further supports the view that triclosan exhibits an anti-inflammatory effect.	Triclosan	17-26	interleukin 1 beta	Homo sapiens	79-87
9584910-6	1998	The finding that triclosan reduces the production of the inflammatory mediator IL-1beta in gingival fibroblasts further supports the view that triclosan exhibits an anti-inflammatory effect.	Triclosan	143-152	interleukin 1 beta	Homo sapiens	79-87
9584910-0	1998	Effect of triclosan on interleukin-1 beta production in human gingival fibroblasts challenged with tumor necrosis factor alpha.	Triclosan	10-19	interleukin 1 beta	Homo sapiens	23-41
9531313-3	1998	IL-1beta and TNF-alpha expression and synthesis were up-regulated by rhIL-17 in a dose (ED50 was 50 +/- 9 ng/ml)- and time-dependent fashion, with cytokine accumulation reaching a zenith after 9 h. Release of IL-6, PGE2, IL-10, IL-12, IL-1R antagonist, and stromelysin was also stimulated by rhIL-17.	Dinoprostone	215-219	interleukin 1 beta	Homo sapiens	0-8
9584910-1	1998	The effect of the dentifrice ingredient triclosan (2,4,4"-trichloro-2"-hydroxyldiphenyl ether) on the production of interleukin (IL)-1beta and IL-6 was studied in human gingival fibroblasts challenged with tumor necrosis factor alpha (TNFalpha) in vitro.	Triclosan	40-49	interleukin 1 beta	Homo sapiens	116-138
9584910-1	1998	The effect of the dentifrice ingredient triclosan (2,4,4"-trichloro-2"-hydroxyldiphenyl ether) on the production of interleukin (IL)-1beta and IL-6 was studied in human gingival fibroblasts challenged with tumor necrosis factor alpha (TNFalpha) in vitro.	2,4,4"-trichloro-2"-hydroxyldiphenyl ether	51-93	interleukin 1 beta	Homo sapiens	116-138
9584910-2	1998	When gingival fibroblasts were treated simultaneously with triclosan (0.25, 0.5 microg/ml) and TNFalpha (10 ng/ml), the stimulatory effect of TNFalpha on IL-1beta production was reduced by the agent.	Triclosan	59-68	interleukin 1 beta	Homo sapiens	154-162
9584910-3	1998	In situ hybridisation showed that the TNFalpha-induced expression of IL-1beta mRNA was significantly reduced by triclosan.	Triclosan	112-121	interleukin 1 beta	Homo sapiens	69-77
9584910-4	1998	Furthermore, when the cells were treated simultaneously with a known protein kinase C (PKC) activator, phorbol 12-myristate-13-acetate (PMA) and TNFalpha in the presence of triclosan (0.5 microg/ml), the agent reduced the production of IL-1beta.	Tetradecanoylphorbol Acetate	103-134	interleukin 1 beta	Homo sapiens	236-244
9558181-1	1998	OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) synthesis and expression in human OA synovial membrane, and on the IL-1beta and TNF-alpha receptors on human OA chondrocytes.	diacerein	47-57	interleukin 1 beta	Homo sapiens	149-166
9525624-4	1998	Apoptosis was significantly inhibited by an interleukin-1beta (IL-1beta)-converting enzyme (ICE)/CED-3 family protease inhibitor, Ac-DEVD-CHO (CPP32; caspase 3), whereas a similar inhibitor of ICE (caspase 1), Ac-YVAD-CHO, had no effect.	acetyl-aspartyl-glutamyl-valyl-aspartal	130-141	interleukin 1 beta	Homo sapiens	44-61
9523575-5	1998	Whereas the antioxidant pyrrolidinedithiocarbamate was only able to inhibit IL-1beta-induced IL-6 expression, inhibition of protein kinase C prevented IL-6 expression induced by all three substances.	pyrrolidine dithiocarbamic acid	24-50	interleukin 1 beta	Homo sapiens	76-84
9558181-5	1998	RESULTS: IL-1beta synthesis was significantly inhibited by diacerhein and rhein, with maximum inhibition at 5.4 x 10(-5) M for diacerhein (p &lt; 0.02) and 3.5 x 10(-5) M for rhein (p &lt; 0.05).	diacerein	59-69	interleukin 1 beta	Homo sapiens	9-17
9525624-4	1998	Apoptosis was significantly inhibited by an interleukin-1beta (IL-1beta)-converting enzyme (ICE)/CED-3 family protease inhibitor, Ac-DEVD-CHO (CPP32; caspase 3), whereas a similar inhibitor of ICE (caspase 1), Ac-YVAD-CHO, had no effect.	L 709049	210-221	interleukin 1 beta	Homo sapiens	44-61
9558181-5	1998	RESULTS: IL-1beta synthesis was significantly inhibited by diacerhein and rhein, with maximum inhibition at 5.4 x 10(-5) M for diacerhein (p &lt; 0.02) and 3.5 x 10(-5) M for rhein (p &lt; 0.05).	diacerein	127-137	interleukin 1 beta	Homo sapiens	9-17
9558181-11	1998	CONCLUSION: Diacerhein and rhein can effectively inhibit the synthesis of IL-1beta on human OA synovium, as well as the action of this cytokine at the cartilage level, by reducing the number of chondrocyte IL-1R.	diacerein	12-22	interleukin 1 beta	Homo sapiens	74-82
9562240-9	1998	IL-1, but not ceramide induced cPLA2 mRNA and protein expression which corresponded with the initiation of PGE2 synthesis.	Dinoprostone	107-111	interleukin 1 beta	Homo sapiens	0-4
9776820-4	1998	In addition, the results consistently demonstrated that at a yeast cell to PBMNC ratio of 20:1, formalin-preserved Malassezia, irrespective of serovar, growth phase or PBMNC donor, were capable of significantly (P&lt;0.05) decreasing the release of both immunochemical IL-6 and IL-1beta plus bioactive IL-1beta and TNF-alpha below that of unstimulated culture medium control values.	Formaldehyde	96-104	interleukin 1 beta	Homo sapiens	278-286
9776820-4	1998	In addition, the results consistently demonstrated that at a yeast cell to PBMNC ratio of 20:1, formalin-preserved Malassezia, irrespective of serovar, growth phase or PBMNC donor, were capable of significantly (P&lt;0.05) decreasing the release of both immunochemical IL-6 and IL-1beta plus bioactive IL-1beta and TNF-alpha below that of unstimulated culture medium control values.	Formaldehyde	96-104	interleukin 1 beta	Homo sapiens	302-310
9562240-0	1998	An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis.	Ceramides	22-30	interleukin 1 beta	Homo sapiens	34-51
9562240-0	1998	An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis.	Prostaglandins	60-73	interleukin 1 beta	Homo sapiens	34-51
9606035-3	1998	This effect was blocked by 1 microM dactinomycin or 10 microM cycloheximide, i.e. the stimulatory effect of IL-1beta depended on de-novo synthesis.	Dactinomycin	36-48	interleukin 1 beta	Homo sapiens	108-116
9562240-1	1998	Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis.	Dinoprostone	48-64	interleukin 1 beta	Homo sapiens	0-17
9587160-0	1998	17 beta-Oestradiol and 1 alpha,25-dihydroxycholecalciferol modulate constitutive and bone matrix-induced interleukin-1 beta (IL-1 beta) production by peripheral blood mononuclear cells isolated from postmenopausal women.	Estradiol	0-18	interleukin 1 beta	Homo sapiens	105-123
9562240-1	1998	Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis.	Dinoprostone	48-64	interleukin 1 beta	Homo sapiens	19-23
9562240-1	1998	Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis.	Dinoprostone	66-70	interleukin 1 beta	Homo sapiens	0-17
9562240-1	1998	Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis.	Dinoprostone	66-70	interleukin 1 beta	Homo sapiens	19-23
9562240-2	1998	We previously showed that ceramide accumulates in fibroblasts treated with IL-1 and that it enhances IL-1-induced PGE2 production.	Ceramides	26-34	interleukin 1 beta	Homo sapiens	75-79
9562240-2	1998	We previously showed that ceramide accumulates in fibroblasts treated with IL-1 and that it enhances IL-1-induced PGE2 production.	Ceramides	26-34	interleukin 1 beta	Homo sapiens	101-105
9562240-2	1998	We previously showed that ceramide accumulates in fibroblasts treated with IL-1 and that it enhances IL-1-induced PGE2 production.	Dinoprostone	114-118	interleukin 1 beta	Homo sapiens	101-105
9562240-3	1998	The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enhance PGE2 production by examining their respective effects on the rate-limiting enzymes in PGE2 synthesis, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2).	Dinoprostone	110-114	interleukin 1 beta	Homo sapiens	85-89
9562240-3	1998	The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enhance PGE2 production by examining their respective effects on the rate-limiting enzymes in PGE2 synthesis, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2).	Dinoprostone	196-200	interleukin 1 beta	Homo sapiens	85-89
9562240-4	1998	IL-1-induced PGE2 synthesis required approximately 8 h even though COX-1 was constitutively expressed (both mRNA and protein) and enzymatically active in untreated cells.	Dinoprostone	13-17	interleukin 1 beta	Homo sapiens	0-4
9562240-7	1998	Ceramide however, reduced the length of time required for IL-1 to induce COX-2 protein accumulation and increased COX-2 protein accumulation.	Ceramides	0-8	interleukin 1 beta	Homo sapiens	58-62
9606035-3	1998	This effect was blocked by 1 microM dactinomycin or 10 microM cycloheximide, i.e. the stimulatory effect of IL-1beta depended on de-novo synthesis.	Cycloheximide	62-75	interleukin 1 beta	Homo sapiens	108-116
9587160-0	1998	17 beta-Oestradiol and 1 alpha,25-dihydroxycholecalciferol modulate constitutive and bone matrix-induced interleukin-1 beta (IL-1 beta) production by peripheral blood mononuclear cells isolated from postmenopausal women.	Estradiol	0-18	interleukin 1 beta	Homo sapiens	125-134
9587160-0	1998	17 beta-Oestradiol and 1 alpha,25-dihydroxycholecalciferol modulate constitutive and bone matrix-induced interleukin-1 beta (IL-1 beta) production by peripheral blood mononuclear cells isolated from postmenopausal women.	Calcitriol	23-58	interleukin 1 beta	Homo sapiens	105-123
9520467-0	1998	Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes.	Budesonide	0-10	interleukin 1 beta	Homo sapiens	95-112
9587160-0	1998	17 beta-Oestradiol and 1 alpha,25-dihydroxycholecalciferol modulate constitutive and bone matrix-induced interleukin-1 beta (IL-1 beta) production by peripheral blood mononuclear cells isolated from postmenopausal women.	Calcitriol	23-58	interleukin 1 beta	Homo sapiens	125-134
9520467-0	1998	Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes.	Dexamethasone	23-36	interleukin 1 beta	Homo sapiens	95-112
9587160-3	1998	Hydroxyapatite (0.5 mg/ml) and heat-denaturated collagen (25 micrograms/ml) stimulated IL-1 beta production 5-fold and 520-fold, respectively, compared to control (p &lt; 0.01).	Durapatite	0-14	interleukin 1 beta	Homo sapiens	87-96
9587160-5	1998	The bone matrix-induced changes in IL-1 beta production were modulated by 10 nmol/1 17 beta-oestradiol and 10 nmol/1 1 alpha,25-dihydroxy-cholecalciferol (1,25(OH)2D3).	beta-oestradiol	87-102	interleukin 1 beta	Homo sapiens	35-44
9587160-5	1998	The bone matrix-induced changes in IL-1 beta production were modulated by 10 nmol/1 17 beta-oestradiol and 10 nmol/1 1 alpha,25-dihydroxy-cholecalciferol (1,25(OH)2D3).	alpha,25-dihydroxy-cholecalciferol	119-153	interleukin 1 beta	Homo sapiens	35-44
9587160-5	1998	The bone matrix-induced changes in IL-1 beta production were modulated by 10 nmol/1 17 beta-oestradiol and 10 nmol/1 1 alpha,25-dihydroxy-cholecalciferol (1,25(OH)2D3).	Calcitriol	155-166	interleukin 1 beta	Homo sapiens	35-44
9587160-6	1998	Specifically, 17 beta oestradiol stimulated constitutive IL-1 beta release with 89% (p &lt; 0.01) and nullified the suppressive effect of TGF-beta.	Estradiol	14-32	interleukin 1 beta	Homo sapiens	57-66
9587160-10	1998	The modulatory effects of oestrogen and vitamin D on constitutive and bone-matrix induced IL-1 beta production by PBMCs may be of importance for bone remodelling during postmenopausal bone loss and at a site of fracture.	Vitamin D	40-49	interleukin 1 beta	Homo sapiens	90-99
9534885-7	1998	Both IL-1 alpha and IL-1 beta showed a stronger growth-stimulatory activity on DF-derived fibroblasts in a dose-dependent manner than normal fibroblasts, and the percent 3H-TdR uptake of DF was 1.4-fold (IL-1 alpha; 1,000 U/ml) and 1.3-fold (IL-1 beta; 1,000 U/ml) as compared with normal fibroblasts; however, the differences did not reach any significance.	Tritium	170-172	interleukin 1 beta	Homo sapiens	20-29
9510209-4	1998	BK also increased the level of secreted immunoreactive IL-1beta in A549 culture supernatants, an effect that was blocked by actinomycin D and the B2 BK receptor antagonist HOE-140.	Dactinomycin	124-137	interleukin 1 beta	Homo sapiens	55-63
9510209-4	1998	BK also increased the level of secreted immunoreactive IL-1beta in A549 culture supernatants, an effect that was blocked by actinomycin D and the B2 BK receptor antagonist HOE-140.	4-hydroxy-2-octenal	172-175	interleukin 1 beta	Homo sapiens	55-63
9506955-4	1998	We now show that, in A549 human alveolar epithelial cells, the activation of a stably transfected NF-kappaB-dependent reporter gene by TNF-alpha and IL-1beta is completely blocked by the phosphatidylcholine-specific phospholipase C inhibitor D609 and the protein kinase C inhibitor RO31-8220.	Phosphatidylcholines	187-206	interleukin 1 beta	Homo sapiens	149-157
9506955-4	1998	We now show that, in A549 human alveolar epithelial cells, the activation of a stably transfected NF-kappaB-dependent reporter gene by TNF-alpha and IL-1beta is completely blocked by the phosphatidylcholine-specific phospholipase C inhibitor D609 and the protein kinase C inhibitor RO31-8220.	tricyclodecane-9-yl-xanthogenate	242-246	interleukin 1 beta	Homo sapiens	149-157
9506955-4	1998	We now show that, in A549 human alveolar epithelial cells, the activation of a stably transfected NF-kappaB-dependent reporter gene by TNF-alpha and IL-1beta is completely blocked by the phosphatidylcholine-specific phospholipase C inhibitor D609 and the protein kinase C inhibitor RO31-8220.	Ro 31-8220	282-291	interleukin 1 beta	Homo sapiens	149-157
9515807-3	1998	We found that PGE2 production by A549 non-small cell lung cancer (NSCLC) cells was elevated up to 50-fold in response to interleukin (IL)-1beta.	Dinoprostone	14-18	interleukin 1 beta	Homo sapiens	121-143
9515807-4	1998	Reversal of IL-1beta-induced PGE2 production in A549 cells was achieved by specific pharmacological or antisense oligonucleotide inhibition of COX-2 activity or expression.	Dinoprostone	29-33	interleukin 1 beta	Homo sapiens	12-20
9515807-4	1998	Reversal of IL-1beta-induced PGE2 production in A549 cells was achieved by specific pharmacological or antisense oligonucleotide inhibition of COX-2 activity or expression.	Oligonucleotides	113-128	interleukin 1 beta	Homo sapiens	12-20
10099239-7	1998	A core N-glycosylation at fused IL-1beta fragment is likely to play a critical role in directing the high-level secretion of rhG-CSF, and the O-glycosylation of secreted rhG-CSF seems nearly negligible.	Nitrogen	7-8	interleukin 1 beta	Homo sapiens	32-40
9602633-7	1998	DEX caused dose dependent inhibition of IL-1 induced IL-8 (p &lt; 0.001) and MCP-1 (p &lt; 0.05) secretion and mRNA expression at all concentrations of rIL-1 beta.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	40-44
9492035-4	1998	It was observed that the NO donor, sodium nitroprusside (SNP), stimulates ir-IL-1beta release under basal conditions, whereas the increase in CO levels obtained with hemin, the CO precursor through the heme oxygenase pathway, has no effect on basal ir-IL-1beta release but inhibits release stimulated by high K+ concentrations.	Nitroprusside	35-55	interleukin 1 beta	Homo sapiens	77-85
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	Dinoprostone	83-87	interleukin 1 beta	Homo sapiens	0-17
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	Dinoprostone	83-87	interleukin 1 beta	Homo sapiens	19-27
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 beta	Homo sapiens	0-17
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 beta	Homo sapiens	19-27
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	bryostatin 1	134-146	interleukin 1 beta	Homo sapiens	0-17
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	bryostatin 1	134-146	interleukin 1 beta	Homo sapiens	19-27
9596483-7	1998	Bryostatin 1 caused a dose-dependent inhibition of the phorbol ester-potentiated IL-1beta response.	bryostatin 1	0-12	interleukin 1 beta	Homo sapiens	81-89
9596483-7	1998	Bryostatin 1 caused a dose-dependent inhibition of the phorbol ester-potentiated IL-1beta response.	Phorbol Esters	55-68	interleukin 1 beta	Homo sapiens	81-89
9492035-4	1998	It was observed that the NO donor, sodium nitroprusside (SNP), stimulates ir-IL-1beta release under basal conditions, whereas the increase in CO levels obtained with hemin, the CO precursor through the heme oxygenase pathway, has no effect on basal ir-IL-1beta release but inhibits release stimulated by high K+ concentrations.	Hemin	166-171	interleukin 1 beta	Homo sapiens	252-260
9525337-9	1998	Dex plus IBMX-induced adipogenesis can be inhibited by interleukin-1beta, tumor necrosis factor-alpha, and transforming growth factor-beta.	Dextromethorphan	0-3	interleukin 1 beta	Homo sapiens	55-101
9667420-4	1998	FK506-induced apoptosis was efficiently attenuated by co-addition of ILs including IL-1beta (2 ng/ml), IL-2 (5 ng/ml) and IL-4 (40 ng/ml) into culture.	Tacrolimus	0-5	interleukin 1 beta	Homo sapiens	83-91
9667420-6	1998	The data also suggested that cytokine networks including those via IL-1beta and IL-4 in addition to IL-2 prevent FK506-induced apoptosis.	Tacrolimus	113-118	interleukin 1 beta	Homo sapiens	67-75
9613675-6	1998	Most were treated with 2-chloro-2"-deoxyadercosine (2-CDA) and treatment was associated with a significant decrease in the serum levels of sIL-2R, IL-1beta and IL-1sRII in patients achieving a complete or partial response.	2-chloro-2"-deoxyadercosine	23-50	interleukin 1 beta	Homo sapiens	147-155
9525337-9	1998	Dex plus IBMX-induced adipogenesis can be inhibited by interleukin-1beta, tumor necrosis factor-alpha, and transforming growth factor-beta.	1-Methyl-3-isobutylxanthine	9-13	interleukin 1 beta	Homo sapiens	55-101
9520946-3	1998	In the present study, we further examined the effects of GHSA on TNF-alpha- and IL-1 beta-induced HRPE IL-8 and monocyte chemoattractant protein (MCP)-1 gene expression and protein secretion in HRPE.	ghsa	57-61	interleukin 1 beta	Homo sapiens	80-89
9548183-1	1998	Elevated uterine concentrations of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumour-necrosis factor-alpha (TNF-alpha) are suspected to cause increased prostaglandin release from gestational tissues, but little information is available about the expression pattern of cytokine receptors in these tissues.	Prostaglandins	164-177	interleukin 1 beta	Homo sapiens	35-52
9517759-13	1998	EIA showed that MTX decreased IL-1beta induced PGE2 production by synoviocytes in a dose dependent manner.	Methotrexate	16-19	interleukin 1 beta	Homo sapiens	30-38
9517759-13	1998	EIA showed that MTX decreased IL-1beta induced PGE2 production by synoviocytes in a dose dependent manner.	Dinoprostone	47-51	interleukin 1 beta	Homo sapiens	30-38
9640061-1	1998	CSF concentrations of TNF-alpha and Il-1 beta were detected in patients with TBE.	tbe	77-80	interleukin 1 beta	Homo sapiens	36-45
9640061-3	1998	CSF Concentrations of TNF-alpha and IL-1 beta in patients with TBE were significantly higher than in control group before as well as after treatment and normalization of CSF parameters.	tbe	63-66	interleukin 1 beta	Homo sapiens	36-45
9545547-6	1998	Administration of diethyldithiocarbamate (DDC) inhibited induction of NF-kappa B and concomitantly the expression of IL-1 beta, IL-6, TNF-alpha as well as iNOS.	Ditiocarb	18-40	interleukin 1 beta	Homo sapiens	117-126
9545547-6	1998	Administration of diethyldithiocarbamate (DDC) inhibited induction of NF-kappa B and concomitantly the expression of IL-1 beta, IL-6, TNF-alpha as well as iNOS.	Ditiocarb	42-45	interleukin 1 beta	Homo sapiens	117-126
9517759-16	1998	CONCLUSION: MTX has an inhibitory effect on IL-1beta stimulated production of PGE2 by cultured human rheumatoid synoviocytes, without affecting either COX mRNA expression.	Methotrexate	12-15	interleukin 1 beta	Homo sapiens	44-52
9517759-16	1998	CONCLUSION: MTX has an inhibitory effect on IL-1beta stimulated production of PGE2 by cultured human rheumatoid synoviocytes, without affecting either COX mRNA expression.	Dinoprostone	78-82	interleukin 1 beta	Homo sapiens	44-52
9517777-2	1998	METHODS: IL-1beta stimulated human chondrocytes were incubated with indomethacin, methotrexate, sulfasalazine, dexamethasone, and methylprednisolone.	Indomethacin	68-80	interleukin 1 beta	Homo sapiens	9-17
9517777-2	1998	METHODS: IL-1beta stimulated human chondrocytes were incubated with indomethacin, methotrexate, sulfasalazine, dexamethasone, and methylprednisolone.	Methotrexate	82-94	interleukin 1 beta	Homo sapiens	9-17
9517777-2	1998	METHODS: IL-1beta stimulated human chondrocytes were incubated with indomethacin, methotrexate, sulfasalazine, dexamethasone, and methylprednisolone.	Sulfasalazine	96-109	interleukin 1 beta	Homo sapiens	9-17
9517777-2	1998	METHODS: IL-1beta stimulated human chondrocytes were incubated with indomethacin, methotrexate, sulfasalazine, dexamethasone, and methylprednisolone.	Dexamethasone	111-124	interleukin 1 beta	Homo sapiens	9-17
9517777-2	1998	METHODS: IL-1beta stimulated human chondrocytes were incubated with indomethacin, methotrexate, sulfasalazine, dexamethasone, and methylprednisolone.	Methylprednisolone	130-148	interleukin 1 beta	Homo sapiens	9-17
9548183-1	1998	Elevated uterine concentrations of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumour-necrosis factor-alpha (TNF-alpha) are suspected to cause increased prostaglandin release from gestational tissues, but little information is available about the expression pattern of cytokine receptors in these tissues.	Prostaglandins	164-177	interleukin 1 beta	Homo sapiens	54-62
9578254-0	1998	Intra-articular injection of hyaluronic acid reduces total amounts of leukotriene C4, 6-keto-prostaglandin F1alpha, prostaglandin F2alpha and interleukin-1beta in synovial fluid of patients with internal derangement in disorders of the temporomandibular joint.	Hyaluronic Acid	29-44	interleukin 1 beta	Homo sapiens	142-159
9535134-3	1998	injection of recombinant human interleukin-1beta (rhIL-1beta) on the activity of efferent nerve fibers innervating the mesenteric lymph node was observed in the urethane anesthetized rat.	Urethane	161-169	interleukin 1 beta	Homo sapiens	31-48
9438552-3	1998	Superoxide production was increased more than twofold following preincubation with IL-1beta, or by the addition of the Ca2+ ionophore, Ionomycin.	Superoxides	0-10	interleukin 1 beta	Homo sapiens	83-91
9538942-2	1998	TCDD has also been shown to modulate cytokine gene expression in human keratinocytes, including IL-1 beta, TGF-alpha and TFG-beta 2.	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Homo sapiens	96-105
9551699-7	1998	CONCLUSION: These findings that leukocyte and platelet counts never increased, despite the increment of the IL-1beta and IL-6 production after the administration of Y-25510, may be explained in part by the negative feedback mechanism induced by IL-10.	Y 25510	165-172	interleukin 1 beta	Homo sapiens	108-116
9536946-7	1998	Ac-Tyr-Val-Ala-Asp-CHO, a specific peptide aldehyde inhibitor of ICE, significantly reduced the amount of mature IL-1 beta released by isolated IBD macrophages (from a median of 1.2 (range 0.78-4.42) ng/ml to 0.43 (0.21-1.6) ng/ml; p &lt; 0.01).	L 709049	0-22	interleukin 1 beta	Homo sapiens	113-122
9543699-6	1998	Blocking of phospholipase D (PLD)-derived diacylglycerol (DAG) formation by propranolol abrogated IFN-gamma increased HLA class II expression and IL-1 beta secretion, but had little effect on IFN-gamma induced TNF-alpha production.	Diglycerides	42-56	interleukin 1 beta	Homo sapiens	146-155
9543699-6	1998	Blocking of phospholipase D (PLD)-derived diacylglycerol (DAG) formation by propranolol abrogated IFN-gamma increased HLA class II expression and IL-1 beta secretion, but had little effect on IFN-gamma induced TNF-alpha production.	Diglycerides	58-61	interleukin 1 beta	Homo sapiens	146-155
9543699-6	1998	Blocking of phospholipase D (PLD)-derived diacylglycerol (DAG) formation by propranolol abrogated IFN-gamma increased HLA class II expression and IL-1 beta secretion, but had little effect on IFN-gamma induced TNF-alpha production.	Propranolol	76-87	interleukin 1 beta	Homo sapiens	146-155
9543699-7	1998	These findings appear to suggest that PLD-derived phosphatidate is not the primary source of DAG production in IFN-gamma-induced TNF-alpha secretion, but may be necessary for IFN-gamma-mediated MHC class II induction and IL-1 beta production in human monocytes, whereas phospholipase A2 may not be required for IFN-gamma activation of PKC in the process.	phosphatidate	50-63	interleukin 1 beta	Homo sapiens	221-230
9616379-7	1998	The stimulation of LPS, rhIFN-gamma and rhIL-1 beta showed more NO induction than that of LPS with either IFN-gamma or IL-1 beta, suggesting the synergistic effects of cytokines.	lps	90-93	interleukin 1 beta	Homo sapiens	42-51
9600205-4	1998	In SK-N-SH cells, a 48 hour (h) treatment with 100 ng/ml IL-1beta, 100 ng/ml TNF-alpha, or 100 nM phorbol 12-myristate 13-acetate induced a 2.7- to 4.2-fold increase in the level of PrP mRNA, while the exposure to 100 ng/ml IFN-gamma resulted in a 50% decrease.	sk-n	3-7	interleukin 1 beta	Homo sapiens	57-65
9529979-6	1998	There was a significant decrease in the rate of DNA synthesis as early as 24 h. The mRNA expression of IL-1 beta and TNFa seemed less influenced by hyperoxia, while IL-8 and TGF beta showed marked increase in mRNA levels at 6 h of 100% oxygen exposure.	Oxygen	236-242	interleukin 1 beta	Homo sapiens	103-112
9553866-0	1998	Coordinate production of PGE2 and IL-1 beta in the gingival crevicular fluid of adults with periodontitis: its relationship to alveolar bone loss and disruption by twice daily treatment with ketorolac tromethamine oral rinse.	ketorolac tromethamine oral rinse	191-224	interleukin 1 beta	Homo sapiens	34-43
9553866-10	1998	Treatment of patients with 0.1% ketorolac tromethamine twice daily for 6 months resulted in reductions of PGE2 in GCF and a negligible correlation between M-GCF PGE2 and M-GCF IL-1 beta (r = 0.42, p = 0.088).	Ketorolac Tromethamine	32-54	interleukin 1 beta	Homo sapiens	176-185
9482542-5	1998	The direct effects of interferon-alpha, interleukin-1beta, and tumor necrosis factor-alpha on glucose-sensitive neurons in two specific regions of the hypothalamus could cause profound changes in eating patterns in animals and humans.	Glucose	94-101	interleukin 1 beta	Homo sapiens	40-57
9507736-8	1998	In experiments investigating the functional consequences of this enhanced monocyte adherence, PAEC stimulation induced 10-fold higher levels of macrophage-derived IL-1 beta and 3-fold higher levels of T cell proliferation compared with HUVEC.	paec	94-98	interleukin 1 beta	Homo sapiens	163-172
9551901-8	1998	In dendritic cells generated from mononuclear progenitors, the protein tyrosine kinase inhibitor genistein was able to block tyrosine phosphorylation as well as production of IL-1beta mRNA transcripts.	Genistein	97-106	interleukin 1 beta	Homo sapiens	175-183
9446586-5	1998	Mutagenesis of a nuclear factor kappaB (NF-kappaB)-like site at -64 to -55 abolished most of the LPS, TNF-alpha, and IL-1beta inducibility, whereas a mutation of a cyclic AMP response element at -50 to -43 markedly reduced the basal promoter activity, and a mutation of the activator protein 1 (AP-1) site at -78 to -72 had minimal effects.	Cyclic AMP	164-174	interleukin 1 beta	Homo sapiens	117-125
9551901-8	1998	In dendritic cells generated from mononuclear progenitors, the protein tyrosine kinase inhibitor genistein was able to block tyrosine phosphorylation as well as production of IL-1beta mRNA transcripts.	Tyrosine	71-79	interleukin 1 beta	Homo sapiens	175-183
9523024-7	1998	PAF induced upregulation of CD11b and CD18 on neutrophils and IL-1 beta increased surface expression of ICAM-1 and VCAM-1 on HUVEC.	Platelet Activating Factor	0-3	interleukin 1 beta	Homo sapiens	62-71
9445252-5	1998	The present study was designed to determine whether the cytokines tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (INF-gamma), and interleukin-1beta (IL-1beta) stimulate tetrahydrobiopterin synthesis by increasing expression of GTP cyclohydrolase I mRNA in endothelial cells.	sapropterin	180-199	interleukin 1 beta	Homo sapiens	141-158
9445252-5	1998	The present study was designed to determine whether the cytokines tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (INF-gamma), and interleukin-1beta (IL-1beta) stimulate tetrahydrobiopterin synthesis by increasing expression of GTP cyclohydrolase I mRNA in endothelial cells.	sapropterin	180-199	interleukin 1 beta	Homo sapiens	160-168
9475519-4	1998	Recombinant human IL-1 beta induced mitogenesis of U373 cells in a dose-dependent fashion as assessed by tritiated thymidine incorporation.	Thymidine	115-124	interleukin 1 beta	Homo sapiens	18-27
9475519-5	1998	The following signal transduction mechanisms, reported to be induced in other systems by IL-1 beta, were investigated in U373 cells: (1) activation of phosphatidylcholine-specific phospholipase C as assayed by incorporation of tritiated choline into cellular phospholipids, (2) production of diacylglycerol, a lipid second messenger, (3) activation of sphingomyelinase, and (4) activation of mitogen-activated protein kinase (MAPK).	Phosphatidylcholines	151-170	interleukin 1 beta	Homo sapiens	89-98
9537674-4	1998	RESULTS: There was a significant inhibition by dexamethasone (from 1 to 100 nM) on the secretion of monokines (IL-1beta, IL-6, IL-8 and TNF alpha) and lymphokines (IL-2, IL-4, IL-10 and IFN gamma), either after LPS or PHA stimulation (P &lt; 0.01).	Dexamethasone	47-60	interleukin 1 beta	Homo sapiens	111-119
9544731-6	1998	Moreover, treatment with IL-1beta (5-50 ng/ml) reduced the increases in electrophoretic mobilities on agarose gels and TBARS formation in association with increases in NO production.	Sepharose	102-109	interleukin 1 beta	Homo sapiens	25-33
9544731-6	1998	Moreover, treatment with IL-1beta (5-50 ng/ml) reduced the increases in electrophoretic mobilities on agarose gels and TBARS formation in association with increases in NO production.	Thiobarbituric Acid Reactive Substances	119-124	interleukin 1 beta	Homo sapiens	25-33
9544731-7	1998	In addition, inhibition of NO production by NG-monomethyl-L-arginine monoacetate reduced the inhibitory effect of IL-1beta on LDL oxidation.	ng-monomethyl-l-arginine monoacetate	44-80	interleukin 1 beta	Homo sapiens	114-122
9551194-3	1998	At a concentration of 0.1 microM, L-glutamic acid completely inhibits the high-affinity binding of 125I-labeled human recombinant interleukin-1 beta (Kd = 0.32 nM) to the HL-60 cells, but does not affect their low-affinity binding (Kd = 13.3 nM) and does not change the total number of the IL-1 beta-binding sites.	Glutamic Acid	34-49	interleukin 1 beta	Homo sapiens	130-148
9551194-3	1998	At a concentration of 0.1 microM, L-glutamic acid completely inhibits the high-affinity binding of 125I-labeled human recombinant interleukin-1 beta (Kd = 0.32 nM) to the HL-60 cells, but does not affect their low-affinity binding (Kd = 13.3 nM) and does not change the total number of the IL-1 beta-binding sites.	Iodine-125	99-103	interleukin 1 beta	Homo sapiens	130-148
9586676-9	1998	As anticipated, IL-1beta induced a marked release of collagenase, stromelysin, IL-6, IL-8 and PGE2.	Dinoprostone	94-98	interleukin 1 beta	Homo sapiens	16-24
9586676-11	1998	These findings suggest a potential role for A/S unsaponifiable extracts in mitigating the deleterious effects of IL-1beta: on cartilage.	Sulfur	46-47	interleukin 1 beta	Homo sapiens	113-121
9805181-0	1998	Serum zinc and copper in active rheumatoid arthritis: correlation with interleukin 1 beta and tumour necrosis factor alpha.	Copper	15-21	interleukin 1 beta	Homo sapiens	71-122
9505146-6	1998	The effect of IL-1 beta was mediated, at least in part, via a cAMP-dependent pathway which did not involve prostaglandin E2 synthesis.	Cyclic AMP	62-66	interleukin 1 beta	Homo sapiens	14-23
9805181-5	1998	IL1 beta and TNF alpha were found to correlate negatively with zinc and positively with copper in RA patients.	Copper	88-94	interleukin 1 beta	Homo sapiens	0-8
9457465-10	1998	TNF-alpha, IL-1 beta, IL-6, and IL-10 were each synergistic or additive with PGE2 in upregulating the promoter.	Dinoprostone	77-81	interleukin 1 beta	Homo sapiens	11-20
9792466-7	1998	(4) E2, DHT and DHEA alone and in combination with IL-1beta and TNFalpha elicited no reproducible dose-dependent effect on IL-6 production, whereas Dexa inhibited basal and IL-1beta and TNFalpha induced IL-6 expression dose dependently.	Dexamethasone	148-152	interleukin 1 beta	Homo sapiens	173-181
9832332-4	1998	Increasing cyclic adenosine nucleotide (cAMP) levels suppressed IL-1beta-induced increases in GMCSF mRNA levels.	cyclic adenosine nucleotide	11-38	interleukin 1 beta	Homo sapiens	64-72
9832332-4	1998	Increasing cyclic adenosine nucleotide (cAMP) levels suppressed IL-1beta-induced increases in GMCSF mRNA levels.	Cyclic AMP	40-44	interleukin 1 beta	Homo sapiens	64-72
9832332-5	1998	In contrast, botulinum toxin C, which mediates the ADP ribosylation of a 21 kD ras-related G protein, augmented IL-1beta-induced GMCSF mRNA expression.	Adenosine Diphosphate	51-54	interleukin 1 beta	Homo sapiens	112-120
9832332-7	1998	Finally, disruption of either microtubules (with colchicine) or microfilaments (with cytochalasin B) resulted in reduced GMCSF mRNA expression in response to IL-1beta.	Cytochalasin B	85-99	interleukin 1 beta	Homo sapiens	158-166
9453318-2	1998	Since nitric oxide inhibits VSMC tone, migration, adhesion, and proliferation, we examined the effects of high glucose on IL-1beta-induced NO release from VSMCs in culture.	Glucose	111-118	interleukin 1 beta	Homo sapiens	122-130
9453318-6	1998	Glucose (10 to 30 mmol/L (mM)) significantly reduced the response to IL-1beta.	Glucose	0-7	interleukin 1 beta	Homo sapiens	69-77
9453318-5	1998	IL-1beta-induced a 15-fold increase in NO production in normal glucose medium.	Glucose	63-70	interleukin 1 beta	Homo sapiens	0-8
9453318-7	1998	High glucose (20 mmol/L (mM)) inhibited IL-1beta-evoked NO production by approximately 50%.	Glucose	5-12	interleukin 1 beta	Homo sapiens	40-48
9453306-1	1998	The proinflammatory cytokine interleukin-1beta (IL) stimulates inducible nitric oxide synthase (iNOS) mRNA, protein, and nitric oxide (NO) production in neonatal ventricular myocytes (NVM).	Nitric Oxide	73-85	interleukin 1 beta	Homo sapiens	29-46
9453318-8	1998	IL-1beta-stimulated [3H] citrulline-forming activity of the nitric oxide synthase (NOS) was also significantly lower in high-glucose-exposed cells, and this was reflected in diminished cellular levels of NOS protein.	Tritium	21-23	interleukin 1 beta	Homo sapiens	0-8
9541457-4	1998	When HUVSMC were activated by individual inflammatory stimuli (IL-1beta, TNFalpha, IFNgamma or LPS), both intra- and extracellular levels of BH4 increased significantly, with TNFalpha being the most potent single stimulus.	sapropterin	141-144	interleukin 1 beta	Homo sapiens	63-71
9453318-8	1998	IL-1beta-stimulated [3H] citrulline-forming activity of the nitric oxide synthase (NOS) was also significantly lower in high-glucose-exposed cells, and this was reflected in diminished cellular levels of NOS protein.	Citrulline	25-35	interleukin 1 beta	Homo sapiens	0-8
9453318-8	1998	IL-1beta-stimulated [3H] citrulline-forming activity of the nitric oxide synthase (NOS) was also significantly lower in high-glucose-exposed cells, and this was reflected in diminished cellular levels of NOS protein.	Glucose	125-132	interleukin 1 beta	Homo sapiens	0-8
9453318-11	1998	1,2-Dioctanoyl-glycerol, a PKC activator, mimicked the high-glucose effect on IL-1beta-induced NO release, while staurosporine, a PKC inhibitor, reversed it.	1,2-dioctanoylglycerol	0-23	interleukin 1 beta	Homo sapiens	78-86
9453318-11	1998	1,2-Dioctanoyl-glycerol, a PKC activator, mimicked the high-glucose effect on IL-1beta-induced NO release, while staurosporine, a PKC inhibitor, reversed it.	Glucose	60-67	interleukin 1 beta	Homo sapiens	78-86
9453318-11	1998	1,2-Dioctanoyl-glycerol, a PKC activator, mimicked the high-glucose effect on IL-1beta-induced NO release, while staurosporine, a PKC inhibitor, reversed it.	Staurosporine	113-126	interleukin 1 beta	Homo sapiens	78-86
9453318-14	1998	Increasing intracellular calcium by A23187, an ionophore or thapsigargin, an inhibitor of endoplasmic reticulum Ca2+-ATPase, significantly decreased IL-1beta-induced NO release and NOS expression.	Calcium	25-32	interleukin 1 beta	Homo sapiens	149-157
9453318-14	1998	Increasing intracellular calcium by A23187, an ionophore or thapsigargin, an inhibitor of endoplasmic reticulum Ca2+-ATPase, significantly decreased IL-1beta-induced NO release and NOS expression.	Calcimycin	36-42	interleukin 1 beta	Homo sapiens	149-157
9453318-14	1998	Increasing intracellular calcium by A23187, an ionophore or thapsigargin, an inhibitor of endoplasmic reticulum Ca2+-ATPase, significantly decreased IL-1beta-induced NO release and NOS expression.	Thapsigargin	60-72	interleukin 1 beta	Homo sapiens	149-157
9453318-15	1998	These results indicate that glucose-induced inhibition of IL-1beta-stimulated NO release and NOS expression may be mediated by PKC activation and increased intracellular calcium.	Glucose	28-35	interleukin 1 beta	Homo sapiens	58-66
9453318-15	1998	These results indicate that glucose-induced inhibition of IL-1beta-stimulated NO release and NOS expression may be mediated by PKC activation and increased intracellular calcium.	Calcium	170-177	interleukin 1 beta	Homo sapiens	58-66
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Val-Gln	26-33	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Val-Gln	26-33	interleukin 1 beta	Homo sapiens	139-147
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Glycine	34-37	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Glycine	34-37	interleukin 1 beta	Homo sapiens	139-147
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Glutamic Acid	38-41	interleukin 1 beta	Homo sapiens	120-137
9777883-0	1998	Effects of beta2-agonists and budesonide on interleukin-1beta and leukotriene B4 secretion: studies of human monocytes and alveolar macrophages.	Budesonide	30-40	interleukin 1 beta	Homo sapiens	44-61
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Glutamic Acid	38-41	interleukin 1 beta	Homo sapiens	139-147
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Glutamic Acid	42-45	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Glutamic Acid	42-45	interleukin 1 beta	Homo sapiens	139-147
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Serine	46-49	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Serine	46-49	interleukin 1 beta	Homo sapiens	139-147
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Asparagine	50-53	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Asparagine	50-53	interleukin 1 beta	Homo sapiens	139-147
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Aspartic Acid	54-57	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Aspartic Acid	54-57	interleukin 1 beta	Homo sapiens	139-147
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Lysine	58-61	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Lysine	58-61	interleukin 1 beta	Homo sapiens	139-147
9777883-3	1998	The influence of four beta2-agonists (salbutamol, terbutaline, formoterol, and salmeterol) and a corticosteroid (budesonide) on the release of interleukin-1beta (IL-1beta) and LTB4 was studied in a dose-response manner (10(-8)-10(-5) mol/L for beta2-agonists and 10(-10)-10(-6) mol/ L for budesonide).	Salmeterol Xinafoate	79-89	interleukin 1 beta	Homo sapiens	143-160
9777883-3	1998	The influence of four beta2-agonists (salbutamol, terbutaline, formoterol, and salmeterol) and a corticosteroid (budesonide) on the release of interleukin-1beta (IL-1beta) and LTB4 was studied in a dose-response manner (10(-8)-10(-5) mol/L for beta2-agonists and 10(-10)-10(-6) mol/ L for budesonide).	Budesonide	113-123	interleukin 1 beta	Homo sapiens	143-160
9777883-5	1998	Budesonide significantly inhibited the release of IL-1beta from blood monocytes (p &lt; 0.001), but no such effect was observed in alveolar macrophages.	Budesonide	0-10	interleukin 1 beta	Homo sapiens	50-58
9777883-7	1998	The beta2-agonists neither influenced the LTB4 nor the IL-beta secretion in either cell type with the exception of formoterol, which stimulated IL-1beta secretion at the highest concentration (10(-5) mol/L, p &lt; 0.05).	Formoterol Fumarate	115-125	interleukin 1 beta	Homo sapiens	144-152
9496240-0	1998	Effects of cortisol on the expression of interleukin-6 and interleukin-1 beta in human osteoblast-like cells.	Hydrocortisone	11-19	interleukin 1 beta	Homo sapiens	59-77
9777883-8	1998	In conclusion, beta2-agonists exhibited only minor effects on IL-1beta secretion from blood monocytes and no effect on LTB4-secretion from either cell type, and budesonide effectively inhibited the IL-1beta release in blood monocytes, but not in alveolar macrophages.	Budesonide	161-171	interleukin 1 beta	Homo sapiens	198-206
9397163-10	1998	Therefore, we suggest that cSAT and c-jun expression is specifically regulated by polyamine-mediated mechanisms in IL-1 beta treated HepG2 cells.	Polyamines	82-91	interleukin 1 beta	Homo sapiens	115-124
9475357-1	1998	Whole-cell pertussis found in diphtheria-tetanus-pertussis (DTP) vaccine can produce symptoms reminiscent of biological responses to circulating proinflammatory monokines such as IL-6, IL-1beta, and TNFalpha.	dtp	60-63	interleukin 1 beta	Homo sapiens	185-193
9397163-6	1998	alpha-Difluoromethylornithine (DFMO) pretreatment, by lowering putrescine and spermidine in HGF- or IL-1 beta-treated cells, prevented the induction of cSAT.	Eflornithine	0-29	interleukin 1 beta	Homo sapiens	100-109
9397163-6	1998	alpha-Difluoromethylornithine (DFMO) pretreatment, by lowering putrescine and spermidine in HGF- or IL-1 beta-treated cells, prevented the induction of cSAT.	Eflornithine	31-35	interleukin 1 beta	Homo sapiens	100-109
9397163-9	1998	DFMO prevented almost completely the enhancement of c-jun mRNA expression by IL-1 beta, and this effect was reversed by exogenous putrescine or spermidine.	Eflornithine	0-4	interleukin 1 beta	Homo sapiens	77-86
9496240-10	1998	The effect of cortisol on IL-1 beta protein released into the culture medium was seen 16 h after the addition of cortisol.	Hydrocortisone	14-22	interleukin 1 beta	Homo sapiens	26-35
15348695-8	1998	Only the cerium fibre inhibited IL-1beta release from macrophages.	Cerium	9-15	interleukin 1 beta	Homo sapiens	32-40
9435177-3	1998	ONO-4007 induced slight production of TNF-alpha, Interleukin (IL)-1 beta, IL-6 and IL-12 in fresh monocytes but strongly induced TNF-alpha production in GM-CSF-treated monocytes.	ONO 4007	0-8	interleukin 1 beta	Homo sapiens	49-72
9564633-7	1998	The aim of our study was to characterize the influence of selegiline on the biosynthesis of IL-1 beta, IL-6 and TNF in human peripheral blood mononuclear cells (PBMC) from healthy blood donors.	Selegiline	58-68	interleukin 1 beta	Homo sapiens	92-101
9564633-10	1998	Treatment of cultured PBMC with various concentrations induced an increased synthesis of IL-1 beta (ANOVA F = 9.703, p = 0.0007), IL-6 (ANOVA F = 20.648, p = 0.0001) and a reduced production of TNF (ANOVA F = 3.770, p = 0.040).	PBMC	22-26	interleukin 1 beta	Homo sapiens	89-98
9627083-0	1998	Down-regulation of interleukin-1beta production and PGE2 accumulation by an indomethacin-phenylalanine derivative in human monocytes.	Indomethacin	76-88	interleukin 1 beta	Homo sapiens	19-36
9489516-8	1998	By contrast, ibandronate enhanced LPS-induced secretion of IL-1beta and IL-6 but did not affect TNFalpha or NO secretion at non-cytotoxic concentrations.	Ibandronic Acid	13-24	interleukin 1 beta	Homo sapiens	59-67
9469590-6	1998	Treatment with cycloheximide prevented the induction of apoB mRNA by IL-1beta, but not by IL-6.	Cycloheximide	15-28	interleukin 1 beta	Homo sapiens	69-77
9469590-9	1998	The pulse-chase study showed that addition of N-acetyl leucyl leucyl norleucinal to the medium induced a decrease in newly synthesized apoB in the cell lysate in response to IL-1beta (P &lt; 0.05) or IL-6 (not to a significant extent) compared with control.	n-acetyl leucyl leucyl	46-68	interleukin 1 beta	Homo sapiens	174-182
9627083-0	1998	Down-regulation of interleukin-1beta production and PGE2 accumulation by an indomethacin-phenylalanine derivative in human monocytes.	Phenylalanine	89-102	interleukin 1 beta	Homo sapiens	19-36
9627083-3	1998	Indomethacin and indo-Phe inhibited the PGE2 synthesis in treated and untreated IL-1beta or LPS-treated monocytes.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	80-88
9627083-3	1998	Indomethacin and indo-Phe inhibited the PGE2 synthesis in treated and untreated IL-1beta or LPS-treated monocytes.	indo-phe	17-25	interleukin 1 beta	Homo sapiens	80-88
9627083-3	1998	Indomethacin and indo-Phe inhibited the PGE2 synthesis in treated and untreated IL-1beta or LPS-treated monocytes.	Dinoprostone	40-44	interleukin 1 beta	Homo sapiens	80-88
9627083-4	1998	Furthermore, in IL-1beta and LPS-treated monocytes, prostaglandin G/H synthase-1 (PGHS-1) protein expression was down-regulated with indomethacin or its indo-Phe analog whereas the level of the inducible protein (PGHS-2) was up-regulated.	Indomethacin	133-145	interleukin 1 beta	Homo sapiens	16-24
9627083-2	1998	We determined the effect of indo-Phe on the induction by LPS of prostaglandin-E2 (PGE2) and interleukin-1beta (IL-1beta) production in human monocytes.	indo-phe	28-36	interleukin 1 beta	Homo sapiens	92-109
9927229-3	1998	The purpose of this study was to determine the relative contributions of COX-1 and COX-2 in the production of prostanoids by human intestinal smooth muscle (HISM) cells when stimulated by interleukin-1beta (IL-1beta) and lipopolysaccharide (LPS).	Prostaglandins	110-121	interleukin 1 beta	Homo sapiens	188-205
9627083-4	1998	Furthermore, in IL-1beta and LPS-treated monocytes, prostaglandin G/H synthase-1 (PGHS-1) protein expression was down-regulated with indomethacin or its indo-Phe analog whereas the level of the inducible protein (PGHS-2) was up-regulated.	Phenylalanine	158-161	interleukin 1 beta	Homo sapiens	16-24
9627083-5	1998	We analyzed the effect of indomethacin and indo-Phe on the expression of IL-1beta protein in LPS-treated monocytes and found that indo-Phe blocked the LPS-induction of IL-1beta synthesis while indomethacin did not.	Indomethacin	26-38	interleukin 1 beta	Homo sapiens	73-81
9627083-5	1998	We analyzed the effect of indomethacin and indo-Phe on the expression of IL-1beta protein in LPS-treated monocytes and found that indo-Phe blocked the LPS-induction of IL-1beta synthesis while indomethacin did not.	indo-phe	43-51	interleukin 1 beta	Homo sapiens	73-81
9627083-5	1998	We analyzed the effect of indomethacin and indo-Phe on the expression of IL-1beta protein in LPS-treated monocytes and found that indo-Phe blocked the LPS-induction of IL-1beta synthesis while indomethacin did not.	indo-phe	130-138	interleukin 1 beta	Homo sapiens	73-81
9627083-5	1998	We analyzed the effect of indomethacin and indo-Phe on the expression of IL-1beta protein in LPS-treated monocytes and found that indo-Phe blocked the LPS-induction of IL-1beta synthesis while indomethacin did not.	indo-phe	130-138	interleukin 1 beta	Homo sapiens	168-176
9627083-5	1998	We analyzed the effect of indomethacin and indo-Phe on the expression of IL-1beta protein in LPS-treated monocytes and found that indo-Phe blocked the LPS-induction of IL-1beta synthesis while indomethacin did not.	Indomethacin	193-205	interleukin 1 beta	Homo sapiens	73-81
9627083-6	1998	These differential effects of indomethacin and indo-Phe suggest that two independent ways are involved in the stimulation of monocytes by LPS: the PGHS-2 protein induction and the IL-1beta secretion.	indo-phe	47-55	interleukin 1 beta	Homo sapiens	180-188
9836494-8	1998	Interleukin-1beta and lipopolysaccharide stimulated the formation of all prostanoids compared with untreated cells, but failed to stimulate leukotriene B4.	Prostaglandins	73-84	interleukin 1 beta	Homo sapiens	0-17
9836494-13	1998	As SC-58125 inhibited lipopolysaccharide and interleukin-1beta induced 6-keto prostaglandin F1alpha production but not prostaglandin E2 production, it suggests that these agents stimulate prostacyclin production through a cyclooxygenase-2 mediated mechanism and prostaglandin E2 production occurs through a cyclooxygenase-1 mediated mechanism.	Epoprostenol	188-200	interleukin 1 beta	Homo sapiens	45-62
9927229-3	1998	The purpose of this study was to determine the relative contributions of COX-1 and COX-2 in the production of prostanoids by human intestinal smooth muscle (HISM) cells when stimulated by interleukin-1beta (IL-1beta) and lipopolysaccharide (LPS).	Prostaglandins	110-121	interleukin 1 beta	Homo sapiens	207-215
9836494-9	1998	Indomethacin at 20 microM concentration, and VSA inhibited lipopolysaccharide and interleukin 1beta stimulated prostaglandin E2, but not 6-keto prostaglandin F1alpha formation.	Dinoprostone	111-127	interleukin 1 beta	Homo sapiens	82-99
9836494-10	1998	SC-58125 inhibited lipopolysaccharide and interleukin-1beta stimulated 6-keto prostaglandin F1alpha but not prostaglandin E2 release.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	0-8	interleukin 1 beta	Homo sapiens	42-59
9927229-10	1998	IL-1beta and LPS increased both PGE2 and 6-keto-PGF1alpha in a dose dependent fashion with enhanced production detected two hours following exposure.	Dinoprostone	32-36	interleukin 1 beta	Homo sapiens	0-8
9836494-10	1998	SC-58125 inhibited lipopolysaccharide and interleukin-1beta stimulated 6-keto prostaglandin F1alpha but not prostaglandin E2 release.	6-Ketoprostaglandin F1 alpha	71-99	interleukin 1 beta	Homo sapiens	42-59
9927229-10	1998	IL-1beta and LPS increased both PGE2 and 6-keto-PGF1alpha in a dose dependent fashion with enhanced production detected two hours following exposure.	6-Ketoprostaglandin F1 alpha	41-57	interleukin 1 beta	Homo sapiens	0-8
9836494-13	1998	As SC-58125 inhibited lipopolysaccharide and interleukin-1beta induced 6-keto prostaglandin F1alpha production but not prostaglandin E2 production, it suggests that these agents stimulate prostacyclin production through a cyclooxygenase-2 mediated mechanism and prostaglandin E2 production occurs through a cyclooxygenase-1 mediated mechanism.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	3-11	interleukin 1 beta	Homo sapiens	45-62
9432117-4	1998	We hypothesized that butyrate may alter the secretion of IL-8 by intestinal epithelial cells in response to stimulation by IL-1beta or lipopolysaccharide.	Butyrates	21-29	interleukin 1 beta	Homo sapiens	123-131
9836494-13	1998	As SC-58125 inhibited lipopolysaccharide and interleukin-1beta induced 6-keto prostaglandin F1alpha production but not prostaglandin E2 production, it suggests that these agents stimulate prostacyclin production through a cyclooxygenase-2 mediated mechanism and prostaglandin E2 production occurs through a cyclooxygenase-1 mediated mechanism.	6-keto prostaglandin	71-91	interleukin 1 beta	Homo sapiens	45-62
9478180-2	1998	OBJECTIVE: To examine the effects of meperidine on the transcription or secretion of Interleukin 1 beta (IL-1 beta) in human mononuclear leukocytes (MNL) exposed in vitro to the lipopolysaccharide (LPS) contained in Escherichia coli endotoxin or to AmB.	Meperidine	37-47	interleukin 1 beta	Homo sapiens	85-103
9478180-2	1998	OBJECTIVE: To examine the effects of meperidine on the transcription or secretion of Interleukin 1 beta (IL-1 beta) in human mononuclear leukocytes (MNL) exposed in vitro to the lipopolysaccharide (LPS) contained in Escherichia coli endotoxin or to AmB.	Meperidine	37-47	interleukin 1 beta	Homo sapiens	105-114
9478180-9	1998	CONCLUSIONS: These data suggest that meperidine decreases rigors and chills in part by decreasing MNL secretion of IL-1 beta through a posttranscriptional mechanism.	Meperidine	37-47	interleukin 1 beta	Homo sapiens	115-124
9432117-0	1998	Butyrate enhances interleukin (IL)-8 secretion by intestinal epithelial cells in response to IL-1beta and lipopolysaccharide.	Butyrates	0-8	interleukin 1 beta	Homo sapiens	93-101
9432117-9	1998	Furthermore, butyrate significantly enhanced IL-8 secretion by cells stimulated with IL-1beta.	Butyrates	13-21	interleukin 1 beta	Homo sapiens	85-93
9460084-5	1998	The autocrine IL-1 beta released by the OA-affected cartilage (for at least 72 hr in ex vivo conditions) is present in sufficient quantities to modulate NO and PGE2 production because addition of recombinant soluble IL-1 beta receptor (but not soluble tumor necrosis factor-alpha receptor) and cytokine-suppressive antiinflammatory drugs (CSAIDs) significantly attenuates the spontaneous release of NO and PGE2.	Dinoprostone	160-164	interleukin 1 beta	Homo sapiens	14-23
9460084-8	1998	These experiments demonstrate that the human OA-affected cartilage itself releases sufficient amounts of functionally active autocrine IL-1 beta that can modulate endogenous NO, PGE2, and IL-6, but not IL-8, all of which are known to be stimulated by IL-1 beta in vitro.	Dinoprostone	178-182	interleukin 1 beta	Homo sapiens	135-144
9460084-5	1998	The autocrine IL-1 beta released by the OA-affected cartilage (for at least 72 hr in ex vivo conditions) is present in sufficient quantities to modulate NO and PGE2 production because addition of recombinant soluble IL-1 beta receptor (but not soluble tumor necrosis factor-alpha receptor) and cytokine-suppressive antiinflammatory drugs (CSAIDs) significantly attenuates the spontaneous release of NO and PGE2.	Dinoprostone	406-410	interleukin 1 beta	Homo sapiens	14-23
9704387-5	1998	After 2 h, mRNAs for IL-1 beta and IL-6 were highly upregulated in noncoated compared to heparin-coated circuits.	Heparin	89-96	interleukin 1 beta	Homo sapiens	21-30
9428650-0	1997	Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression.	cholest-5-en-3 beta,7 alpha-diol	61-85	interleukin 1 beta	Homo sapiens	30-47
9416887-6	1997	Inhibition of TF induction in the presence of high CsA blood concentrations was also observed when stimulation of cells was performed with interferon-gamma or interleukin-1beta.	Cyclosporine	51-54	interleukin 1 beta	Homo sapiens	159-176
9428650-0	1997	Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression.	7-ketocholesterol	90-107	interleukin 1 beta	Homo sapiens	30-47
9428650-4	1997	7Beta-hydroxycholesterol and 7-ketocholesterol induced nuclear condensation and/or fragmentation, internucleosomal DNA fragmentation, and IL-1beta secretion, which were partially inhibited by Bcl-2 overexpression.	cholest-5-en-3 beta,7 alpha-diol	0-24	interleukin 1 beta	Homo sapiens	138-146
9550423-6	1997	Enzymatic conversion from the 31-kDa to the 17.5-kDa form of IL-1beta was blocked by addition of a highly specific aldehyde inhibitor that contained a tetrapeptide recognition sequence specific for ICE, but not by an aldehyde inhibitor of a related ICE-like cysteine protease.	Aldehydes	115-123	interleukin 1 beta	Homo sapiens	61-69
9428650-4	1997	7Beta-hydroxycholesterol and 7-ketocholesterol induced nuclear condensation and/or fragmentation, internucleosomal DNA fragmentation, and IL-1beta secretion, which were partially inhibited by Bcl-2 overexpression.	7-ketocholesterol	29-46	interleukin 1 beta	Homo sapiens	138-146
9428650-5	1997	These findings underline that these oxysterols could constitute major risk factors in atherosclerosis by their cytotoxicity and their ability to induce IL-1beta release which might favor the recruitment of immunocompetent cells in the atherosclerotic plaque.	Oxysterols	36-46	interleukin 1 beta	Homo sapiens	152-160
9405225-5	1997	Supplementing HMC with the BH4 donor sepiapterin potentiated IL-1beta/TNF-alpha-induced COX-2 expression by approximately 2-fold.	sepiapterin	37-48	interleukin 1 beta	Homo sapiens	61-69
9405225-5	1997	Supplementing HMC with the BH4 donor sepiapterin potentiated IL-1beta/TNF-alpha-induced COX-2 expression by approximately 2-fold.	sapropterin	27-30	interleukin 1 beta	Homo sapiens	61-69
9409559-7	1997	Actinomycin D pretreatment of A549 monolayers had no effect on FMLP-induced neutrophil transepithelial migration, but markedly (about 75%) inhibited both TNF-alpha- and IL-1beta-induced neutrophil transepithelial migration, regardless of monolayer orientation.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	169-177
9435641-0	1997	Epinephrine inhibits endotoxin-induced IL-1 beta production: roles of tumor necrosis factor-alpha and IL-10.	Epinephrine	0-11	interleukin 1 beta	Homo sapiens	39-48
9416852-6	1997	RESULTS: IL-1beta at 10 pg/ml caused a 60% decrease in 35S-proteoglycan synthesis.	Sulfur-35	55-58	interleukin 1 beta	Homo sapiens	9-17
9416852-8	1997	The presence of 50 ng/ml OP-1 in the IL-1beta-containing medium was effective in restoring 35S-proteoglycan synthesis to the level of that found in cultures not treated with IL-1beta.	Sulfur-35	91-94	interleukin 1 beta	Homo sapiens	37-45
9404762-9	1997	In the same patients, the relationships between serum sE-selectin and BALF concentrations of IL-1 beta as well as between serum sL-selectin and BALF IL-8 were also significant.	se-selectin	54-65	interleukin 1 beta	Homo sapiens	93-102
9408252-7	1997	Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	237-268	interleukin 1 beta	Homo sapiens	88-105
9371735-5	1997	The relative potencies of GC drugs as inhibitors of IL-1beta (10 pM)-stimulated ESAP-gene activation were fluticasone&gt; beclomethasone&gt;dexamethasone, with IC50 values of 0.13, 1.1 and 2.7 nM respectively.	Fluticasone	106-117	interleukin 1 beta	Homo sapiens	52-60
9371735-5	1997	The relative potencies of GC drugs as inhibitors of IL-1beta (10 pM)-stimulated ESAP-gene activation were fluticasone&gt; beclomethasone&gt;dexamethasone, with IC50 values of 0.13, 1.1 and 2.7 nM respectively.	Beclomethasone	122-136	interleukin 1 beta	Homo sapiens	52-60
9371735-5	1997	The relative potencies of GC drugs as inhibitors of IL-1beta (10 pM)-stimulated ESAP-gene activation were fluticasone&gt; beclomethasone&gt;dexamethasone, with IC50 values of 0.13, 1.1 and 2.7 nM respectively.	Dexamethasone	140-153	interleukin 1 beta	Homo sapiens	52-60
9404762-10	1997	Treatment of DPB patients with macrolides significantly reduced the serum levels of these soluble adhesion molecules and BALF concentrations of IL-1 beta and IL-8.	Macrolides	31-41	interleukin 1 beta	Homo sapiens	144-153
9389514-7	1997	NMMA, added to islets 24 h after the addition of IL-1beta, followed by continued culture for 72 h (with NMMA and IL-1beta), prevents islet degeneration.	omega-N-Methylarginine	0-4	interleukin 1 beta	Homo sapiens	113-121
9417812-0	1997	Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes.	Fatty Acids, Unsaturated	11-34	interleukin 1 beta	Homo sapiens	38-55
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	Fatty Acids, Unsaturated	147-174	interleukin 1 beta	Homo sapiens	25-42
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	Fatty Acids, Unsaturated	147-174	interleukin 1 beta	Homo sapiens	44-52
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	8,11,14-Eicosatrienoic Acid	175-200	interleukin 1 beta	Homo sapiens	25-42
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	8,11,14-Eicosatrienoic Acid	175-200	interleukin 1 beta	Homo sapiens	44-52
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	8,11,14-Eicosatrienoic Acid	202-206	interleukin 1 beta	Homo sapiens	25-42
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	8,11,14-Eicosatrienoic Acid	202-206	interleukin 1 beta	Homo sapiens	44-52
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	Arachidonic Acid	212-228	interleukin 1 beta	Homo sapiens	25-42
9417812-2	1997	It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide.	Arachidonic Acid	212-228	interleukin 1 beta	Homo sapiens	44-52
9389514-3	1997	The addition of N(G)-monomethyl-L-arginine (NMMA) or aminoguanidine to islets preincubated for 18 h with IL-1beta, followed by continued culture for 8 h (with both NMMA and IL-1beta), results in the recovery of islet secretory function, aconitase activity, and protein synthesis.	omega-N-Methylarginine	16-42	interleukin 1 beta	Homo sapiens	105-113
9389514-3	1997	The addition of N(G)-monomethyl-L-arginine (NMMA) or aminoguanidine to islets preincubated for 18 h with IL-1beta, followed by continued culture for 8 h (with both NMMA and IL-1beta), results in the recovery of islet secretory function, aconitase activity, and protein synthesis.	omega-N-Methylarginine	16-42	interleukin 1 beta	Homo sapiens	173-181
9389514-7	1997	NMMA, added to islets 24 h after the addition of IL-1beta, followed by continued culture for 72 h (with NMMA and IL-1beta), prevents islet degeneration.	omega-N-Methylarginine	0-4	interleukin 1 beta	Homo sapiens	49-57
9389546-11	1997	IL-1beta treatment up-regulates the expression of IL-1alpha, IL-1beta, and PGE2.	Dinoprostone	75-79	interleukin 1 beta	Homo sapiens	0-8
9389514-9	1997	New messenger RNA expression appears to be required for islet recovery from IL-1beta-induced damage as actinomycin D prevents the recovery of islet aconitase activity.	Dactinomycin	103-116	interleukin 1 beta	Homo sapiens	76-84
9389514-11	1997	NMMA, when cocultured with IL-1beta + IFNgamma, completely prevents cytokine-induced inhibition of human islet aconitase activity.	omega-N-Methylarginine	0-4	interleukin 1 beta	Homo sapiens	27-35
9389514-12	1997	NMMA, when added to human islets pretreated for 18 h with IL-1beta + IFNgamma, stimulates the recovery of mitochondrial aconitase activity after an additional 8 h incubation.	omega-N-Methylarginine	0-4	interleukin 1 beta	Homo sapiens	58-66
9389514-13	1997	These findings indicate that nitric oxide-induced islet damage is reversible; however, prolonged production of nitric oxide (after a 36-h exposure to IL-1beta) results in the irreversible inhibition of islet metabolic and secretory function.	Nitric Oxide	111-123	interleukin 1 beta	Homo sapiens	150-158
9464576-6	1997	Differential modulation of the production of IL-1beta and IL-6 was observed; amrinone and pimobendan enhanced the production of IL-1beta, whereas vesnarinone did not.	Amrinone	77-85	interleukin 1 beta	Homo sapiens	45-53
9459616-3	1997	In fact, on SK-N-SH neuroblastoma cells, IL-1beta can inhibit the Ca++ increase induced by stimulation of acetylcholine receptors with carbachol.	Carbachol	135-144	interleukin 1 beta	Homo sapiens	41-49
9442384-5	1997	In human hepatoma cell lines stimulation with IL-1 beta, IL-6, TNF-alpha and dexamethasone leads to strong transcriptional activation of the LBP gene in a dose- and time-dependent manner.	Dexamethasone	77-90	interleukin 1 beta	Homo sapiens	46-55
9466128-2	1997	Reductions in the production of pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) have been seen in humans after short-term n-3 fatty acid supplementation.	Fatty Acids, Omega-3	200-214	interleukin 1 beta	Homo sapiens	59-77
9394732-1	1997	BACKGROUND &amp; AIMS: The cytokine interleukin (IL)-1 beta induces collagenase expression and inhibits collagen expression in human intestinal smooth muscle (HISM) cells.	Adenosine Monophosphate	12-15	interleukin 1 beta	Homo sapiens	36-59
9394732-8	1997	RESULTS: A 30-fold induction of collagenase mRNA and collagenase protein secretion by IL-1 beta was completely abrogated by dexamethasone.	Dexamethasone	124-137	interleukin 1 beta	Homo sapiens	86-95
9394732-9	1997	Dexamethasone at 10(-6) mol/L also reduced basal levels of collagenase mRNA by 50% and blocked the IL-1 beta-induced inhibition of collagen secretion.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	99-108
9393811-8	1997	IL-1beta maturation was severely retarded by YVAD, indicating that IL-1beta-converting enzyme (ICE; caspase 1) is activated in Shigella-induced apoptosis.	YVAD	45-49	interleukin 1 beta	Homo sapiens	0-8
9393811-8	1997	IL-1beta maturation was severely retarded by YVAD, indicating that IL-1beta-converting enzyme (ICE; caspase 1) is activated in Shigella-induced apoptosis.	YVAD	45-49	interleukin 1 beta	Homo sapiens	67-75
9464576-6	1997	Differential modulation of the production of IL-1beta and IL-6 was observed; amrinone and pimobendan enhanced the production of IL-1beta, whereas vesnarinone did not.	Amrinone	77-85	interleukin 1 beta	Homo sapiens	128-136
9464576-6	1997	Differential modulation of the production of IL-1beta and IL-6 was observed; amrinone and pimobendan enhanced the production of IL-1beta, whereas vesnarinone did not.	pimobendan	90-100	interleukin 1 beta	Homo sapiens	45-53
9464576-6	1997	Differential modulation of the production of IL-1beta and IL-6 was observed; amrinone and pimobendan enhanced the production of IL-1beta, whereas vesnarinone did not.	pimobendan	90-100	interleukin 1 beta	Homo sapiens	128-136
9485518-4	1997	ONO-5046.Na significantly inhibited the production of IL-1 beta and IL-6 at the doses between 10(-9) and 10(-7) M, and TNF-alpha at the doses between 10(-9) and 10(-4) M. These results suggest that ONO-5046.Na at clinically available concentrations can inhibit the cytokine production by monocytes.	sivelestat	0-8	interleukin 1 beta	Homo sapiens	54-63
9436821-7	1997	The IL-1beta-stimulated increase in nitrite formation, iNOS protein, and mRNA abundance in VSMCs was significantly augmented in the presence of thiopental (100 microM), whereas methohexital, hexobarbital, pentobarbital, and phenobarbital were without effect.	Nitrites	36-43	interleukin 1 beta	Homo sapiens	4-12
9436821-7	1997	The IL-1beta-stimulated increase in nitrite formation, iNOS protein, and mRNA abundance in VSMCs was significantly augmented in the presence of thiopental (100 microM), whereas methohexital, hexobarbital, pentobarbital, and phenobarbital were without effect.	Thiopental	144-154	interleukin 1 beta	Homo sapiens	4-12
9436821-7	1997	The IL-1beta-stimulated increase in nitrite formation, iNOS protein, and mRNA abundance in VSMCs was significantly augmented in the presence of thiopental (100 microM), whereas methohexital, hexobarbital, pentobarbital, and phenobarbital were without effect.	Pentobarbital	205-218	interleukin 1 beta	Homo sapiens	4-12
9436821-7	1997	The IL-1beta-stimulated increase in nitrite formation, iNOS protein, and mRNA abundance in VSMCs was significantly augmented in the presence of thiopental (100 microM), whereas methohexital, hexobarbital, pentobarbital, and phenobarbital were without effect.	Phenobarbital	224-237	interleukin 1 beta	Homo sapiens	4-12
9436821-8	1997	The potentiating effect of thiopental was observed only when the barbiturate was administered during the first 2 h of the 24-h incubation period of cultured VSMCs with IL-1beta.	Thiopental	27-37	interleukin 1 beta	Homo sapiens	168-176
9436821-8	1997	The potentiating effect of thiopental was observed only when the barbiturate was administered during the first 2 h of the 24-h incubation period of cultured VSMCs with IL-1beta.	barbituric acid	65-76	interleukin 1 beta	Homo sapiens	168-176
9436821-10	1997	This barbiturate also significantly augmented the hyporeactivity to phenylephrine in carotid arteries exposed to IL-1beta, an effect that was abolished by N(G)-nitro-L-arginine.	barbituric acid	5-16	interleukin 1 beta	Homo sapiens	113-121
9436821-10	1997	This barbiturate also significantly augmented the hyporeactivity to phenylephrine in carotid arteries exposed to IL-1beta, an effect that was abolished by N(G)-nitro-L-arginine.	Phenylephrine	68-81	interleukin 1 beta	Homo sapiens	113-121
9436821-10	1997	This barbiturate also significantly augmented the hyporeactivity to phenylephrine in carotid arteries exposed to IL-1beta, an effect that was abolished by N(G)-nitro-L-arginine.	Nitroarginine	155-176	interleukin 1 beta	Homo sapiens	113-121
9436821-12	1997	These findings demonstrate that the thiobarbiturate thiopental, but not oxybarbiturates, augments the IL-1beta-stimulated synthesis of NO in both cultured and native VSMCs.	thiobarbituric acid	36-51	interleukin 1 beta	Homo sapiens	102-110
9436821-12	1997	These findings demonstrate that the thiobarbiturate thiopental, but not oxybarbiturates, augments the IL-1beta-stimulated synthesis of NO in both cultured and native VSMCs.	Thiopental	52-62	interleukin 1 beta	Homo sapiens	102-110
9548465-1	1997	We previously demonstrated that IL-1beta-mediated induction of the nuclear factor-kappaB (NF-kappaB) transcription factor proceeds through the production of reactive oxygen intermediates in lymphoid cells, while it occurs independently of any oxidative stress in epithelial transformed cells.	Oxygen	166-172	interleukin 1 beta	Homo sapiens	32-40
9548465-2	1997	Indeed, inhibition of receptor internalization as well as NH4Cl and chloroquine blocked IL-1beta-mediated induction of NF-kappaB in OVCAR-3 and in other epithelial cell lines but not in lymphoid cells, indicating that distinct pathways are involved.	Ammonium Chloride	58-63	interleukin 1 beta	Homo sapiens	88-96
9548465-2	1997	Indeed, inhibition of receptor internalization as well as NH4Cl and chloroquine blocked IL-1beta-mediated induction of NF-kappaB in OVCAR-3 and in other epithelial cell lines but not in lymphoid cells, indicating that distinct pathways are involved.	Chloroquine	68-79	interleukin 1 beta	Homo sapiens	88-96
9548465-5	1997	This study thus indicates that the activation of NF-kappaB following IL-1beta treatment involves the activation of phospholipase A2 and 5-LOX and the production of reactive oxygen intermediates (ROIs) in lymphoid cells, while in epithelial cells, another pathway predominates and could involve the acid sphingomyelinase.	reactive oxygen intermediates	164-193	interleukin 1 beta	Homo sapiens	69-77
9469643-3	1997	Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells.	2-(4-(3-methyl-2-thienyl)phenyl)propionic acid	7-13	interleukin 1 beta	Homo sapiens	127-144
9469643-3	1997	Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells.	2-(4-(3-methyl-2-thienyl)phenyl)propionic acid	7-13	interleukin 1 beta	Homo sapiens	146-154
9469643-3	1997	Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells.	Ketoprofen	17-27	interleukin 1 beta	Homo sapiens	127-144
9469643-3	1997	Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells.	Ketoprofen	17-27	interleukin 1 beta	Homo sapiens	146-154
9469643-3	1997	Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells.	Dinoprostone	47-68	interleukin 1 beta	Homo sapiens	127-144
9469643-3	1997	Either M-5011 or ketoprofen potently inhibited prostaglandin (PG) E2 production by cyclooxygenase (COX)-2 from exogenous AA in interleukin-1beta (IL-1beta)-stimulated cells.	Dinoprostone	47-68	interleukin 1 beta	Homo sapiens	146-154
9430742-8	1997	IL-1 beta stimulated amnion cell 5-HETE production as expected.	5-hydroxy-6,8,11,14-eicosatetraenoic acid	33-39	interleukin 1 beta	Homo sapiens	0-9
9386173-11	1997	TNF-alpha and IL-1beta alone but not IL-6 attenuated the dilatation to bradykinin and arachidonic acid; the response was greatest at 1 hour with recovery occurring by 6 hours.	Arachidonic Acid	86-102	interleukin 1 beta	Homo sapiens	14-22
9430742-9	1997	However, 5-HETE production by amnion cells was significantly inhibited by incubation with IL-10 and CsA, and both significantly attenuated 5-HETE production in response to IL-1 beta.	5-hydroxy-6,8,11,14-eicosatetraenoic acid	9-15	interleukin 1 beta	Homo sapiens	172-181
9430742-9	1997	However, 5-HETE production by amnion cells was significantly inhibited by incubation with IL-10 and CsA, and both significantly attenuated 5-HETE production in response to IL-1 beta.	5-hydroxy-6,8,11,14-eicosatetraenoic acid	139-145	interleukin 1 beta	Homo sapiens	172-181
9434142-7	1997	Stimulation of 3H-AA release by EGF (10 nM), IL-1beta (1 ng ml-1) and bradykinin (100 nM) was unaffected by these concentrations of tamoxifen.	3h-aa	15-20	interleukin 1 beta	Homo sapiens	45-53
9449430-5	1997	The glucocorticoid dexamethasone inhibited the IL-1beta-activated release of IL-6 from the postmortem astrocyte cultures A157 and A295 and from the astroglioma cell lines.	Dexamethasone	19-32	interleukin 1 beta	Homo sapiens	47-55
9449430-7	1997	This post-mortem astrocyte culture was found to produce large amounts of PGE2 upon stimulation with IL-1beta, whereas in the supernatants of the postmortem astrocyte culture A295 and the astroglioma cell lines, low PGE2 concentrations were detected.	Dinoprostone	73-77	interleukin 1 beta	Homo sapiens	100-108
9449430-8	1997	Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.	Dinoprostone	22-26	interleukin 1 beta	Homo sapiens	92-100
9449430-8	1997	Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.	Dinoprostone	22-26	interleukin 1 beta	Homo sapiens	92-96
9449430-8	1997	Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.	Indomethacin	62-74	interleukin 1 beta	Homo sapiens	92-100
9449430-8	1997	Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.	Indomethacin	62-74	interleukin 1 beta	Homo sapiens	92-96
9449430-8	1997	Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.	Biofor 389	79-84	interleukin 1 beta	Homo sapiens	92-100
9449430-8	1997	Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the IL-1beta-activated IL-6 release from A157 astrocytes and largely potentiated the IL-1-induced release of IL-6 from all astrocytes/astroglioma cells tested.	Biofor 389	79-84	interleukin 1 beta	Homo sapiens	92-96
9449430-9	1997	Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta-activated IL-6 release could not be prevented by the addition of PGE2.	Dexamethasone	122-135	interleukin 1 beta	Homo sapiens	143-151
9449430-9	1997	Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta-activated IL-6 release could not be prevented by the addition of PGE2.	Dinoprostone	217-221	interleukin 1 beta	Homo sapiens	143-151
9347929-4	1997	Our findings suggest that chronic lead and cadmium exposure in humans resulted in significant suppression of the serum IL-1beta level, but did not alter IL-2 and TNF-alpha levels.	Cadmium	43-50	interleukin 1 beta	Homo sapiens	119-127
9414112-3	1997	However, superinduction of IL-1beta-induced COX-2 mRNA levels by cycloheximide in pulmonary type II A549 cells occurred by increased transcription and not by mRNA stabilisation.	Cycloheximide	65-78	interleukin 1 beta	Homo sapiens	27-35
9359864-4	1997	The cell-permeable ceramide analogues C2 and C6 each greatly potentiated induction of both CRP and SAA mRNA by IL-6+IL-1beta but did not affect the responses of alpha-fibrinogen to IL-6 or to IL-6+IL-1beta.	Ceramides	19-27	interleukin 1 beta	Homo sapiens	116-124
9359864-4	1997	The cell-permeable ceramide analogues C2 and C6 each greatly potentiated induction of both CRP and SAA mRNA by IL-6+IL-1beta but did not affect the responses of alpha-fibrinogen to IL-6 or to IL-6+IL-1beta.	Ceramides	19-27	interleukin 1 beta	Homo sapiens	197-205
9359864-5	1997	The combination of IL-6+IL-1beta led to increased turnover of sphingomyelin in Hep3B cells.	Sphingomyelins	62-75	interleukin 1 beta	Homo sapiens	24-32
9359864-6	1997	D609, an inhibitor of ceramide production by acidic but not neutral sphingomyelinases, substantially inhibited induction of CRP and SAA by IL-6+IL-1beta.	tricyclodecane-9-yl-xanthogenate	0-4	interleukin 1 beta	Homo sapiens	144-152
9359864-7	1997	The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in induction of CRP and SAA by IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta.	Sphingomyelins	82-95	interleukin 1 beta	Homo sapiens	162-170
9359864-7	1997	The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in induction of CRP and SAA by IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta.	Sphingomyelins	82-95	interleukin 1 beta	Homo sapiens	250-258
9359864-7	1997	The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in induction of CRP and SAA by IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta.	Ceramides	96-104	interleukin 1 beta	Homo sapiens	162-170
9359864-7	1997	The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in induction of CRP and SAA by IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta.	Ceramides	96-104	interleukin 1 beta	Homo sapiens	250-258
9366434-6	1997	Analysis of cytokine secretion revealed that, in addition to MIP-1 alpha, L-NMMA inhibited the release of mature IL-1 beta (by 70%) and TNF-alpha (by 53%).	omega-N-Methylarginine	74-80	interleukin 1 beta	Homo sapiens	113-122
9408996-11	1997	Chromatography of human interleukin-1 beta (hIL-1 beta) and several other proteins containing a single surface-exposed histidine surrounded by several hydrophobic residues confirmed that such a sequence could also serve as a very effective metal binding domain for protein purification using immobilized copper(II) columns.	Histidine	119-128	interleukin 1 beta	Homo sapiens	24-42
9408996-11	1997	Chromatography of human interleukin-1 beta (hIL-1 beta) and several other proteins containing a single surface-exposed histidine surrounded by several hydrophobic residues confirmed that such a sequence could also serve as a very effective metal binding domain for protein purification using immobilized copper(II) columns.	Histidine	119-128	interleukin 1 beta	Homo sapiens	44-54
9408996-11	1997	Chromatography of human interleukin-1 beta (hIL-1 beta) and several other proteins containing a single surface-exposed histidine surrounded by several hydrophobic residues confirmed that such a sequence could also serve as a very effective metal binding domain for protein purification using immobilized copper(II) columns.	Metals	240-245	interleukin 1 beta	Homo sapiens	24-42
9408996-11	1997	Chromatography of human interleukin-1 beta (hIL-1 beta) and several other proteins containing a single surface-exposed histidine surrounded by several hydrophobic residues confirmed that such a sequence could also serve as a very effective metal binding domain for protein purification using immobilized copper(II) columns.	Metals	240-245	interleukin 1 beta	Homo sapiens	44-54
9408996-11	1997	Chromatography of human interleukin-1 beta (hIL-1 beta) and several other proteins containing a single surface-exposed histidine surrounded by several hydrophobic residues confirmed that such a sequence could also serve as a very effective metal binding domain for protein purification using immobilized copper(II) columns.	Copper	304-310	interleukin 1 beta	Homo sapiens	24-42
9408996-11	1997	Chromatography of human interleukin-1 beta (hIL-1 beta) and several other proteins containing a single surface-exposed histidine surrounded by several hydrophobic residues confirmed that such a sequence could also serve as a very effective metal binding domain for protein purification using immobilized copper(II) columns.	Copper	304-310	interleukin 1 beta	Homo sapiens	44-54
9372670-8	1997	There was a trend towards lower IL-1 beta levels in DSCG-treated infants on Day 7, but IL-1ra levels were unaffected by DSCG therapy.	Cromolyn Sodium	52-56	interleukin 1 beta	Homo sapiens	32-41
9374730-3	1997	In human ASM cells loaded with fura 2, TNF-alpha and interleukin (IL)-1 beta significantly enhanced thrombin- and bradykinin-evoked elevations of intracellular Ca2+.	Fura-2	31-37	interleukin 1 beta	Homo sapiens	53-76
9375864-11	1997	IL-1beta, alone or in combinations, was dominant with respect to stimulation of PGE2 synthesis.	Dinoprostone	80-84	interleukin 1 beta	Homo sapiens	0-8
9374789-5	1997	Poly(I-C)-induced monocytic cell adhesion to primary EC was concentration-dependently inhibited by 40-74% by the nitric oxide synthase (NOS) inhibitor NG-methyl-L-arginine (L-NMA), as well as three other NOS inhibitors, without significantly affecting interleukin-1 beta-induced adhesion.	Poly I-C	0-8	interleukin 1 beta	Homo sapiens	252-270
9374789-5	1997	Poly(I-C)-induced monocytic cell adhesion to primary EC was concentration-dependently inhibited by 40-74% by the nitric oxide synthase (NOS) inhibitor NG-methyl-L-arginine (L-NMA), as well as three other NOS inhibitors, without significantly affecting interleukin-1 beta-induced adhesion.	l-nma	173-178	interleukin 1 beta	Homo sapiens	252-270
9409229-0	1997	Regulation of tumor necrosis factor alpha- and interleukin-1-beta-induced induced adhesion molecule expression in human vascular smooth muscle cells by cAMP.	Cyclic AMP	152-156	interleukin 1 beta	Homo sapiens	47-65
9409229-5	1997	Cicaprost as well as forskolin significantly inhibited TNF-alpha- and IL-1 beta-induced cell surface expression of ICAM-1 and VCAM-1.	cicaprost	0-9	interleukin 1 beta	Homo sapiens	70-79
9409229-5	1997	Cicaprost as well as forskolin significantly inhibited TNF-alpha- and IL-1 beta-induced cell surface expression of ICAM-1 and VCAM-1.	Colforsin	21-30	interleukin 1 beta	Homo sapiens	70-79
9409229-6	1997	Semiquantitative rt-PCR measurements showed a marked decrease of TNF-alpha- and IL-1 beta-induced mRNA levels of both adhesion molecules after preincubation with cicaprost.	cicaprost	162-171	interleukin 1 beta	Homo sapiens	80-89
9426183-12	1997	We also show that a ROS-independent mechanism is activated by IL-1beta in epithelial cells and seems to involve the acidic sphingomyelinase/ceramide transduction pathway.	Reactive Oxygen Species	20-23	interleukin 1 beta	Homo sapiens	62-70
9426183-12	1997	We also show that a ROS-independent mechanism is activated by IL-1beta in epithelial cells and seems to involve the acidic sphingomyelinase/ceramide transduction pathway.	Ceramides	140-148	interleukin 1 beta	Homo sapiens	62-70
9394834-10	1997	In addition, the up-regulation of CD86 expression on DC treated with DNCB was significantly suppressed by either anti-IL-1 beta or anti-TNF-alpha antibody, while that by NiCl2 was relatively insensitive to these antibody treatments.	Dinitrochlorobenzene	69-73	interleukin 1 beta	Homo sapiens	118-127
9393919-9	1997	Both IL-1beta and TNFalpha stimulated IL-6 and PGE2 release from the osteoblast-like cells.	Dinoprostone	47-51	interleukin 1 beta	Homo sapiens	5-13
9359732-2	1997	CNI-1493 inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 production whether or not LPS stimulation was enhanced by interferon (IFN)-gamma priming.	semapimod	0-8	interleukin 1 beta	Homo sapiens	112-120
9408881-5	1997	However, PGE2 production induced by IL-1 beta was significantly more than with ceramide alone, and there was no potentiation of PGE2 production with coincubation of ceramide and IL-1 beta.	Dinoprostone	9-13	interleukin 1 beta	Homo sapiens	36-45
9374680-1	1997	Although interleukin-1 beta (IL-1 beta) reduces pancreatic islet content of ATP and GTP, the distal events that mediate its inhibitory effects on insulin secretion remain poorly understood.	Adenosine Triphosphate	76-79	interleukin 1 beta	Homo sapiens	9-27
9374680-1	1997	Although interleukin-1 beta (IL-1 beta) reduces pancreatic islet content of ATP and GTP, the distal events that mediate its inhibitory effects on insulin secretion remain poorly understood.	Adenosine Triphosphate	76-79	interleukin 1 beta	Homo sapiens	29-38
9374680-1	1997	Although interleukin-1 beta (IL-1 beta) reduces pancreatic islet content of ATP and GTP, the distal events that mediate its inhibitory effects on insulin secretion remain poorly understood.	Guanosine Triphosphate	84-87	interleukin 1 beta	Homo sapiens	9-27
9374680-1	1997	Although interleukin-1 beta (IL-1 beta) reduces pancreatic islet content of ATP and GTP, the distal events that mediate its inhibitory effects on insulin secretion remain poorly understood.	Guanosine Triphosphate	84-87	interleukin 1 beta	Homo sapiens	29-38
9374680-3	1997	An 18-h exposure to IL-1 beta (100 pM) totally vitiated activation of PLC induced by glucose, an effect that requires ATP and GTP and closure of the ATP-dependent K+ (KATP) channel.	Glucose	85-92	interleukin 1 beta	Homo sapiens	20-29
9374680-3	1997	An 18-h exposure to IL-1 beta (100 pM) totally vitiated activation of PLC induced by glucose, an effect that requires ATP and GTP and closure of the ATP-dependent K+ (KATP) channel.	Adenosine Triphosphate	118-121	interleukin 1 beta	Homo sapiens	20-29
9374680-3	1997	An 18-h exposure to IL-1 beta (100 pM) totally vitiated activation of PLC induced by glucose, an effect that requires ATP and GTP and closure of the ATP-dependent K+ (KATP) channel.	Guanosine Triphosphate	126-129	interleukin 1 beta	Homo sapiens	20-29
9374680-3	1997	An 18-h exposure to IL-1 beta (100 pM) totally vitiated activation of PLC induced by glucose, an effect that requires ATP and GTP and closure of the ATP-dependent K+ (KATP) channel.	Adenosine Triphosphate	149-152	interleukin 1 beta	Homo sapiens	20-29
9374680-5	1997	IL-1 beta also reduced the labeling of phosphoinositide substrates; however, this effect was insufficient to explain the inhibition of PLC, since the effects on substrate labeling, but not on PLC, were prevented by coprovision of guanosine or adenosine.	Phosphatidylinositols	39-55	interleukin 1 beta	Homo sapiens	0-9
9374680-5	1997	IL-1 beta also reduced the labeling of phosphoinositide substrates; however, this effect was insufficient to explain the inhibition of PLC, since the effects on substrate labeling, but not on PLC, were prevented by coprovision of guanosine or adenosine.	Guanosine	230-239	interleukin 1 beta	Homo sapiens	0-9
9374680-5	1997	IL-1 beta also reduced the labeling of phosphoinositide substrates; however, this effect was insufficient to explain the inhibition of PLC, since the effects on substrate labeling, but not on PLC, were prevented by coprovision of guanosine or adenosine.	Adenosine	243-252	interleukin 1 beta	Homo sapiens	0-9
9374680-6	1997	Furthermore, when IL-1 beta-treated islets were exposed to 100 microM carbachol (which activates PLC partially independent of extracellular Ca2+), the effects were still obliterated by IL-1 beta.	Carbachol	70-79	interleukin 1 beta	Homo sapiens	18-27
9374680-6	1997	Furthermore, when IL-1 beta-treated islets were exposed to 100 microM carbachol (which activates PLC partially independent of extracellular Ca2+), the effects were still obliterated by IL-1 beta.	Carbachol	70-79	interleukin 1 beta	Homo sapiens	185-194
9374680-7	1997	These data (together with the finding that IL-1 beta inhibited Ca(2+)-induced insulin release) suggest that, in addition to its effects on ATP synthesis and thereby on the KATP channel, IL-1 beta has at least two undescribed, distal effects to block both PLC as well as Ca(2+)-induced exocytosis.	Adenosine Triphosphate	139-142	interleukin 1 beta	Homo sapiens	186-195
9374680-8	1997	The latter correlated best with IL-1 beta"s effect to impede phosphoinositide synthesis, since it also was reversed by guanosine or adenosine.	Phosphatidylinositols	61-77	interleukin 1 beta	Homo sapiens	32-41
9374680-8	1997	The latter correlated best with IL-1 beta"s effect to impede phosphoinositide synthesis, since it also was reversed by guanosine or adenosine.	Guanosine	119-128	interleukin 1 beta	Homo sapiens	32-41
9374680-8	1997	The latter correlated best with IL-1 beta"s effect to impede phosphoinositide synthesis, since it also was reversed by guanosine or adenosine.	Adenosine	132-141	interleukin 1 beta	Homo sapiens	32-41
9353419-0	1997	Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine.	Dinoprostone	61-77	interleukin 1 beta	Homo sapiens	32-49
9353419-0	1997	Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine.	hymenialdisine	118-132	interleukin 1 beta	Homo sapiens	32-49
9353419-1	1997	Exposure of human rheumatoid synovial fibroblasts (RSF) to interleukin 1beta (IL-1beta) results in the coordinate up-regulation of 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX II) and subsequent biosynthesis of prostaglandin E2 (PGE2).	Dinoprostone	239-255	interleukin 1 beta	Homo sapiens	59-76
9353419-1	1997	Exposure of human rheumatoid synovial fibroblasts (RSF) to interleukin 1beta (IL-1beta) results in the coordinate up-regulation of 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX II) and subsequent biosynthesis of prostaglandin E2 (PGE2).	Dinoprostone	239-255	interleukin 1 beta	Homo sapiens	78-86
9353419-1	1997	Exposure of human rheumatoid synovial fibroblasts (RSF) to interleukin 1beta (IL-1beta) results in the coordinate up-regulation of 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX II) and subsequent biosynthesis of prostaglandin E2 (PGE2).	Dinoprostone	257-261	interleukin 1 beta	Homo sapiens	59-76
9353419-1	1997	Exposure of human rheumatoid synovial fibroblasts (RSF) to interleukin 1beta (IL-1beta) results in the coordinate up-regulation of 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX II) and subsequent biosynthesis of prostaglandin E2 (PGE2).	Dinoprostone	257-261	interleukin 1 beta	Homo sapiens	78-86
9353419-3	1997	Hymenialdisine, a marine natural product has recently been characterized as an inhibitor of NFkappaB activation and exposure of IL-1-stimulated RSF-inhibited PGE2 production in a concentration-dependent manner (IC50 approximately 1 microM).	hymenialdisine	0-14	interleukin 1 beta	Homo sapiens	128-132
9353419-3	1997	Hymenialdisine, a marine natural product has recently been characterized as an inhibitor of NFkappaB activation and exposure of IL-1-stimulated RSF-inhibited PGE2 production in a concentration-dependent manner (IC50 approximately 1 microM).	Dinoprostone	158-162	interleukin 1 beta	Homo sapiens	128-132
9353419-5	1997	Direct action of hymenialdisine on IL-1-induced NFkappaB activation was demonstrated by a significant reduction (approximately 80%) in NFkappaB binding to the classical kappaB consensus motif (as assessed by electrophoretic mobility shift assay) and inhibition of stimulated p65 migration from the cytosol of treated cells (as assessed by Western analysis).	hymenialdisine	17-31	interleukin 1 beta	Homo sapiens	35-39
9353419-8	1997	Specificity of action is suggested as IL-1-stimulated interleukin-8 (IL-8) production, which is known to be an NFkappaB-regulated event, was also inhibited by hymenialdisine, whereas IL-1-induced production of vascular endothelial growth factor, a non-NFkappaB-regulated gene, was not affected by exposure to hymenialdisine.	hymenialdisine	159-173	interleukin 1 beta	Homo sapiens	38-42
9353419-8	1997	Specificity of action is suggested as IL-1-stimulated interleukin-8 (IL-8) production, which is known to be an NFkappaB-regulated event, was also inhibited by hymenialdisine, whereas IL-1-induced production of vascular endothelial growth factor, a non-NFkappaB-regulated gene, was not affected by exposure to hymenialdisine.	hymenialdisine	309-323	interleukin 1 beta	Homo sapiens	38-42
9353419-9	1997	Taken together, hymenialdisine inhibits IL-1-stimulated-RSF PGE2 formation acting predominately through modulation of NFkappaB activation and offers an interesting novel tool to evaluate the role of NFkappaB in inflammatory disease.	hymenialdisine	16-30	interleukin 1 beta	Homo sapiens	40-44
9353419-9	1997	Taken together, hymenialdisine inhibits IL-1-stimulated-RSF PGE2 formation acting predominately through modulation of NFkappaB activation and offers an interesting novel tool to evaluate the role of NFkappaB in inflammatory disease.	Dinoprostone	60-64	interleukin 1 beta	Homo sapiens	40-44
9375864-16	1997	This effect was profoundly reduced by the antagonistic effect of IL-1beta, mediated in part by PGE2.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	65-73
9536288-5	1997	TGF beta and dexamethasone inhibited IL-1 induced ILA expression.	Dexamethasone	13-26	interleukin 1 beta	Homo sapiens	37-41
9591299-8	1997	In acute phase of meningitis correlations between CSF concentration of TNF-alpha and IL-1 beta and other indexes of inflammation in CSF: pleocytosis, concentration of protein and glucose were found.	Glucose	179-186	interleukin 1 beta	Homo sapiens	85-94
9536288-10	1997	However, repression of ILA in fibroblasts and dedifferentiated chondrocytes was overcome by cycloheximide and IL-1 further increased ILA mRNA levels in the presence of cycloheximide.	Cycloheximide	168-181	interleukin 1 beta	Homo sapiens	110-114
9491209-4	1997	Mofezolac suppressed the mRNA expression for IL-1 beta in PBMC stimulated with exogenous IL-1 beta, indicating the secreted IL-1ra in the presence of mofezolac to be biologically active.	mofezolac	0-9	interleukin 1 beta	Homo sapiens	45-54
9491209-4	1997	Mofezolac suppressed the mRNA expression for IL-1 beta in PBMC stimulated with exogenous IL-1 beta, indicating the secreted IL-1ra in the presence of mofezolac to be biologically active.	mofezolac	0-9	interleukin 1 beta	Homo sapiens	89-98
9491209-4	1997	Mofezolac suppressed the mRNA expression for IL-1 beta in PBMC stimulated with exogenous IL-1 beta, indicating the secreted IL-1ra in the presence of mofezolac to be biologically active.	mofezolac	150-159	interleukin 1 beta	Homo sapiens	45-54
9491209-5	1997	Since IL-1ra suppresses the function of IL-1, a pro-inflammatory cytokine, the stimulatory effect of such NSAIDs as mofezolac on IL-1ra production could also be one of the mechanisms involved in its anti-inflammatory and antinociceptive actions.	mofezolac	116-125	interleukin 1 beta	Homo sapiens	6-10
9376570-4	1997	We show here that the sulfonylurea glyburide, currently used in the oral therapy of noninsulin dependent diabetes, is an inhibitor of IL-1beta secretion from human monocytes and mouse macrophages.	Sulfonylurea Compounds	22-34	interleukin 1 beta	Homo sapiens	134-142
9334358-4	1997	NG-monomethyl-L-arginine, an inhibitor of nitric oxide (NO) synthase, prevents IL-1beta-induced Fas expression, whereas the NO donors sodium nitroprusside and nitric oxide releasing compound (NOC)-18, induce functional Fas expression in normal pancreatic beta cells.	omega-N-Methylarginine	0-24	interleukin 1 beta	Homo sapiens	79-87
9376570-4	1997	We show here that the sulfonylurea glyburide, currently used in the oral therapy of noninsulin dependent diabetes, is an inhibitor of IL-1beta secretion from human monocytes and mouse macrophages.	Glyburide	35-44	interleukin 1 beta	Homo sapiens	134-142
9376570-5	1997	Glyburide reduces dramatically the recovery of extracellular 17-kD IL-1beta in the absence of toxic effects on the cells and without affecting the synthesis or processing of the IL-1beta precursor.	Glyburide	0-9	interleukin 1 beta	Homo sapiens	67-75
9357823-7	1997	Cytokines interleukin-1beta (IL-1beta), basic fibroblast growth factor, IL-2, epidermal growth factor, and transforming growth factor-beta modulated steady-state levels of Eck and B61 mRNA and regulated Eck activation as assessed by tyrosine phosphorylation.	Tyrosine	233-241	interleukin 1 beta	Homo sapiens	10-27
9378988-3	1997	The inhibitory effect of IFN-gamma on poly(I:C)-induced E-selectin was concentration and time dependent and was specific for dsRNA, in that the induction of E-selectin by TNF-alpha, IL-1 beta, thrombin, or LPS was not inhibited significantly by this pretreatment.	Carbon	45-47	interleukin 1 beta	Homo sapiens	182-191
9357758-2	1997	We characterized the mechanisms by which hyaluronic acid (HA) regulates interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) production in human uterine fibroblasts.	Hyaluronic Acid	41-56	interleukin 1 beta	Homo sapiens	72-89
9357758-2	1997	We characterized the mechanisms by which hyaluronic acid (HA) regulates interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) production in human uterine fibroblasts.	Hyaluronic Acid	41-56	interleukin 1 beta	Homo sapiens	91-99
9357758-2	1997	We characterized the mechanisms by which hyaluronic acid (HA) regulates interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) production in human uterine fibroblasts.	Hyaluronic Acid	58-60	interleukin 1 beta	Homo sapiens	72-89
9357758-2	1997	We characterized the mechanisms by which hyaluronic acid (HA) regulates interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) production in human uterine fibroblasts.	Hyaluronic Acid	58-60	interleukin 1 beta	Homo sapiens	91-99
9354314-4	1997	Luminol-dependent chemiluminescence and NO generation were measured in polymorphonuclear leukocytes (PMN) and HUVEC and generation of interleukin-1 beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha), and prostaglandin E2 (PGE2) as well as expression of these cytokines" mRNA were examined in lymphocytes, monocytes, PMN, and HUVEC.	Luminol	0-7	interleukin 1 beta	Homo sapiens	134-152
9354314-4	1997	Luminol-dependent chemiluminescence and NO generation were measured in polymorphonuclear leukocytes (PMN) and HUVEC and generation of interleukin-1 beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha), and prostaglandin E2 (PGE2) as well as expression of these cytokines" mRNA were examined in lymphocytes, monocytes, PMN, and HUVEC.	Luminol	0-7	interleukin 1 beta	Homo sapiens	154-162
9352314-8	1997	Increasing concentrations of dbcAMP progressively reduced the production of TNF-alpha and IL-1 beta but not IL-8.	Bucladesine	29-35	interleukin 1 beta	Homo sapiens	90-99
9336233-6	1997	Interestingly, however, SP selectively potentiated the inducing effect of IL-1beta on IL-6 and PGE2 secretion by spinal cord astrocytes without affecting the IL-1-beta-evoked secretion of other cytokines.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	74-82
9352015-6	1997	IL-1 beta and IL-4 also caused six- and two-fold increases, respectively, in culture fluid PGE2 concentrations.	Dinoprostone	91-95	interleukin 1 beta	Homo sapiens	0-9
9352015-8	1997	CONCLUSIONS: Based on these results, it is proposed that IL-1 beta and IL-4 may be involved in the initiation and promotion of labor by inducing EP1 levels and PGE2 production in amnion.	Dinoprostone	160-164	interleukin 1 beta	Homo sapiens	57-66
9357823-7	1997	Cytokines interleukin-1beta (IL-1beta), basic fibroblast growth factor, IL-2, epidermal growth factor, and transforming growth factor-beta modulated steady-state levels of Eck and B61 mRNA and regulated Eck activation as assessed by tyrosine phosphorylation.	Tyrosine	233-241	interleukin 1 beta	Homo sapiens	29-37
9402285-0	1997	Possible contribution of follicular interleukin-1beta to nitric oxide generation in human pre-ovulatory follicles.	Nitric Oxide	57-69	interleukin 1 beta	Homo sapiens	36-53
9415030-8	1997	Northern blot analysis demonstrated that cycloheximide and actinomycin D abolished the effect of IL-1.	Cycloheximide	41-54	interleukin 1 beta	Homo sapiens	97-101
9402285-3	1997	Both follicular nitrite (r = 0.42, P &lt; 0.01) and nitrate (r = 0.49, P &lt; 0.001) were found to be significantly correlated with follicular IL-1beta concentrations.	Nitrites	16-23	interleukin 1 beta	Homo sapiens	143-151
9415030-8	1997	Northern blot analysis demonstrated that cycloheximide and actinomycin D abolished the effect of IL-1.	Dactinomycin	59-72	interleukin 1 beta	Homo sapiens	97-101
9402285-3	1997	Both follicular nitrite (r = 0.42, P &lt; 0.01) and nitrate (r = 0.49, P &lt; 0.001) were found to be significantly correlated with follicular IL-1beta concentrations.	Nitrates	52-59	interleukin 1 beta	Homo sapiens	143-151
9402285-5	1997	When follicular cells were incubated in vitro with 10 ng/ml of IL-1beta for 24 h, nitrate generation was significantly (P &lt; 0.01) elevated compared with the control.	Nitrates	82-89	interleukin 1 beta	Homo sapiens	63-71
9312169-0	1997	1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1beta production.	Calcitriol	0-24	interleukin 1 beta	Homo sapiens	118-135
9312169-1	1997	We hypothesized that 1,25-dihydroxyvitamin D3 (1,25D3) and its analogues may inhibit acute myelogenous leukemia (AML) proliferation by interrupting IL-1beta-mediated growth-stimulatory signals.	Calcitriol	21-45	interleukin 1 beta	Homo sapiens	148-156
9312169-2	1997	The incubation of the IL-1beta- responsive AML cell line OCIM2 with 10 nM 1,25D3 reduced growth 80% in liquid culture, and a 100-1000-fold lower concentration of 20-epi analogues (MC1288 and MC1301) was sufficient to achieve similar growth inhibition.	Calcitriol	180-186	interleukin 1 beta	Homo sapiens	22-30
9312169-2	1997	The incubation of the IL-1beta- responsive AML cell line OCIM2 with 10 nM 1,25D3 reduced growth 80% in liquid culture, and a 100-1000-fold lower concentration of 20-epi analogues (MC1288 and MC1301) was sufficient to achieve similar growth inhibition.	MC 1301	191-197	interleukin 1 beta	Homo sapiens	22-30
9326272-3	1997	However, elevating cyclic AMP levels within the cells by these agents suppressed interleukin-1beta- and tumor necrosis factor-alpha-induced adhesion molecule expression at both the mRNA and protein levels.	Cyclic AMP	19-29	interleukin 1 beta	Homo sapiens	81-131
9349985-6	1997	CsA (1, 5, and 10ng/ml) significantly reduced IL-1 beta-induced IL-8 production (by 32%, 41%, and 48%, respectively), and reduced TNF alpha-induced IL-8 production (by 21%, 42%, and 50%, respectively).	Cyclosporine	0-3	interleukin 1 beta	Homo sapiens	46-55
9401927-5	1997	This result suggests that endogenous prostaglandin E2 (PGE2) partially inhibits IL-1 or TNF-alpha-induced IL-6 production and that the enhancement of IL-6 production by IL-1 or TNF-alpha may not be caused through endogenous PGE2-induced cAMP-dependent pathway.	Dinoprostone	55-59	interleukin 1 beta	Homo sapiens	80-84
9343751-6	1997	SaS also induced the release of TNF-alpha and IL-1 beta by human monocytes.	sas	0-3	interleukin 1 beta	Homo sapiens	46-55
9358286-6	1997	Additionally, we showed that staurosporin restored metabolic responses that chondrocytes in primary culture exhibit upon interleukin-1 beta treatment (decrease of Alcian blue- positive cells, induction of expression of the 92 kDa gelatinase, nitric oxide production).	Staurosporine	29-41	interleukin 1 beta	Homo sapiens	121-139
9358286-6	1997	Additionally, we showed that staurosporin restored metabolic responses that chondrocytes in primary culture exhibit upon interleukin-1 beta treatment (decrease of Alcian blue- positive cells, induction of expression of the 92 kDa gelatinase, nitric oxide production).	Alcian Blue	163-174	interleukin 1 beta	Homo sapiens	121-139
9363475-8	1997	In contrast, NO2 caused a concentration-dependent inhibition of the secretion of all cytokines except IL-1 beta from smoker"s cells.	Nitrogen Dioxide	13-16	interleukin 1 beta	Homo sapiens	102-111
9363475-12	1997	Nitrogen dioxide also failed to elevate the levels of the mRNAs in non-smoker"s cells but, again, tended to diminish the levels, particularly of IL-1 beta mRNA.	Nitrogen Dioxide	0-16	interleukin 1 beta	Homo sapiens	145-154
9401927-4	1997	This IL-1 alpha, IL-1 beta, or TNF-alpha-induced IL-6 production was enhanced, but the cAMP accumulation they induced was inhibited by the addition of indomethacin.	Indomethacin	151-163	interleukin 1 beta	Homo sapiens	17-26
9401927-6	1997	Dexamethasone (DEX), a glucocorticoid which is a inhibitor of nuclear factor kappa B (NF-kappa B activation, markedly inhibited IL-1 (alpha or beta) or TNF-alpha-induced IL-6 production; so this production may be partially mediated through NF-kappa B.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	128-147
9401927-5	1997	This result suggests that endogenous prostaglandin E2 (PGE2) partially inhibits IL-1 or TNF-alpha-induced IL-6 production and that the enhancement of IL-6 production by IL-1 or TNF-alpha may not be caused through endogenous PGE2-induced cAMP-dependent pathway.	Dinoprostone	37-53	interleukin 1 beta	Homo sapiens	80-84
9401927-6	1997	Dexamethasone (DEX), a glucocorticoid which is a inhibitor of nuclear factor kappa B (NF-kappa B activation, markedly inhibited IL-1 (alpha or beta) or TNF-alpha-induced IL-6 production; so this production may be partially mediated through NF-kappa B.	Dexamethasone	15-18	interleukin 1 beta	Homo sapiens	128-147
9401927-10	1997	Accordingly, in inflamed periodontal tissues, gingival fibroblasts and periodontal ligament fibroblasts stimulated with pro-inflammatory cytokines such as IL-1 or TNF-alpha, may produce IL-6, and this production can be differentially modulated by endogenous PGE2, IL-6sR, T cell-derived cytokines such as IFN-gamma or IL-4, and glucocorticoids.	Dinoprostone	258-262	interleukin 1 beta	Homo sapiens	155-159
9324056-11	1997	These data suggest that IL-1beta, IL-6 and TNF-alpha display more than additive effects on Sertoli cell transferrin and cGMP secretion and that the combination of these cytokines may explain the major part of the effects observed with crude PBMC-CM.	Cyclic GMP	120-124	interleukin 1 beta	Homo sapiens	24-32
9299508-0	1997	2,3,7,8-Tetrachlorodibenzo-p-dioxin increases mRNA levels for interleukin-1beta, urokinase plasminogen activator, and tumor necrosis factor-alpha in human uterine endometrial adenocarcinoma RL95-2 cells.	Polychlorinated Dibenzodioxins	0-35	interleukin 1 beta	Homo sapiens	62-79
9299508-4	1997	TCDD significantly increased mRNA levels for interleukin-1beta (IL-1beta) by 6h, and for urokinase plasminogen activator (uPA) and tumor necrosis factor-alpha (TNF-alpha) by 36h.	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Homo sapiens	45-62
9299508-4	1997	TCDD significantly increased mRNA levels for interleukin-1beta (IL-1beta) by 6h, and for urokinase plasminogen activator (uPA) and tumor necrosis factor-alpha (TNF-alpha) by 36h.	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Homo sapiens	64-72
9342736-0	1997	Effects of IL-1 beta on receptor-mediated poly-phosphoinositide signaling pathway in immortalized astrocytes (DITNC).	Phosphatidylinositol Phosphates	42-63	interleukin 1 beta	Homo sapiens	11-20
9342736-3	1997	In this study, an immortalized astrocyte cell line (DITNC) was used to test the effect of IL-1 beta exposure on the poly-PI signaling pathway.	Phosphatidylinositol Phosphates	116-123	interleukin 1 beta	Homo sapiens	90-99
9342736-8	1997	On the other hand, an increase in ATP response could be observed in DITNC cells exposed to conditioned medium obtained after IL-1 beta treatment.	Adenosine Triphosphate	34-37	interleukin 1 beta	Homo sapiens	125-134
9330472-9	1997	Delivery of interleukin-1 beta as a cytokine adjuvant with M-FP immunizations also enhanced antibody responses to levels fourfold that induced by M-FP alone without adversely affecting the cytotoxic activity induced by M-FP immunization.	m-fp	59-63	interleukin 1 beta	Homo sapiens	12-30
9330472-9	1997	Delivery of interleukin-1 beta as a cytokine adjuvant with M-FP immunizations also enhanced antibody responses to levels fourfold that induced by M-FP alone without adversely affecting the cytotoxic activity induced by M-FP immunization.	m-fp	146-150	interleukin 1 beta	Homo sapiens	12-30
9325192-0	1997	Spontaneous induction of nitric oxide- and prostaglandin E2-release by hypoxic astroglial cells is modulated by interleukin 1 beta.	Nitric Oxide	25-37	interleukin 1 beta	Homo sapiens	112-130
9325192-0	1997	Spontaneous induction of nitric oxide- and prostaglandin E2-release by hypoxic astroglial cells is modulated by interleukin 1 beta.	Dinoprostone	43-59	interleukin 1 beta	Homo sapiens	112-130
9315521-9	1997	Modulation of IL-1beta production by amiodarone was biphasic and significantly increased at a concentration of 10 micromol/L.	Amiodarone	37-47	interleukin 1 beta	Homo sapiens	14-22
9315538-5	1997	Ouabain induced the production of interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in PBMC and induced mRNA of these cytokines, an induction apparently at the transcriptional level.	Ouabain	0-7	interleukin 1 beta	Homo sapiens	34-56
9292571-13	1997	The incubation with a glucose polymer solution (7.5% glucose polymer in phosphate-buffered saline, pH 7.3) resulted in a significantly lowered cytokine release (LPS stimulation: IL-1beta, 69 +/- 19 pg/mL) compared with the other solutions with neutral pH (P &lt; 0.01).	Glucose	22-29	interleukin 1 beta	Homo sapiens	178-186
9298128-1	1997	The in vitro growth of human hair follicles is inhibited by interleukin (IL)-1 beta and phorbol esters, such as phorbol-myristate-acetate (PMA), but enhanced by insulin-like growth factor (IGF)-I.	Tetradecanoylphorbol Acetate	139-142	interleukin 1 beta	Homo sapiens	60-83
9292571-9	1997	Significantly higher IL-6 and IL-1beta release was found in the bicarbonate-buffered solutions, both under basal conditions and after LPS stimulation, compared with the lactate-buffered solutions (LPS stimulation: 1% amino acids/34 mmol/L bicarbonate, IL-1beta: 1,166 +/- 192 pg/mL; 1.5% glucose/34 mmol/L bicarbonate, IL-1beta: 752 +/- 107 pg/mL; 1.5% glucose/35 mmol/L lactate/pH 5.5, IL-1beta: 174 +/- 51 pg/mL).	Bicarbonates	64-75	interleukin 1 beta	Homo sapiens	30-38
9309306-8	1997	Consequently, these results suggest that physiologically relevant concentrations of ethanol may affect production of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 by disrupting NF-kappa B signaling in monocytes.	Ethanol	84-91	interleukin 1 beta	Homo sapiens	178-196
9292571-13	1997	The incubation with a glucose polymer solution (7.5% glucose polymer in phosphate-buffered saline, pH 7.3) resulted in a significantly lowered cytokine release (LPS stimulation: IL-1beta, 69 +/- 19 pg/mL) compared with the other solutions with neutral pH (P &lt; 0.01).	Glucose	53-60	interleukin 1 beta	Homo sapiens	178-186
9292571-13	1997	The incubation with a glucose polymer solution (7.5% glucose polymer in phosphate-buffered saline, pH 7.3) resulted in a significantly lowered cytokine release (LPS stimulation: IL-1beta, 69 +/- 19 pg/mL) compared with the other solutions with neutral pH (P &lt; 0.01).	Phosphate-Buffered Saline	72-97	interleukin 1 beta	Homo sapiens	178-186
9308913-7	1997	To determine whether this effect was cytokine specific, interleukin-1beta (IL-1beta) and macrophage inflammatory protein-1alpha (MIP-1alpha) were evaluated, and DETA NONOate was also found to inhibit both of these cytokines.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	161-173	interleukin 1 beta	Homo sapiens	56-73
9322624-5	1997	RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta.	Dinoprostone	150-166	interleukin 1 beta	Homo sapiens	75-93
9316497-6	1997	Staurosporine reduced the downmodulation by low-level IL-8 plus LTB4 or IL-1 beta but not by high-level IL-8 alone.	Staurosporine	0-13	interleukin 1 beta	Homo sapiens	72-81
9316506-6	1997	IL-1 beta-induced increases in Bmax with IL-1 beta were associated with approximately threefold increases in beta 2 AR mRNA and were blocked by the protein synthesis inhibitor cycloheximide.	Cycloheximide	176-189	interleukin 1 beta	Homo sapiens	0-9
9316506-6	1997	IL-1 beta-induced increases in Bmax with IL-1 beta were associated with approximately threefold increases in beta 2 AR mRNA and were blocked by the protein synthesis inhibitor cycloheximide.	Cycloheximide	176-189	interleukin 1 beta	Homo sapiens	41-50
9316506-7	1997	Despite the marked increase in Bmax, however, IL-1 beta depressed adenosine 3",5"-cyclic monophosphate (cAMP) responses to isoproterenol and forskolin, a direct activator of AC (P &lt; 0.001 by analysis of variance for both).	Cyclic AMP	66-102	interleukin 1 beta	Homo sapiens	46-55
9316506-7	1997	Despite the marked increase in Bmax, however, IL-1 beta depressed adenosine 3",5"-cyclic monophosphate (cAMP) responses to isoproterenol and forskolin, a direct activator of AC (P &lt; 0.001 by analysis of variance for both).	Cyclic AMP	104-108	interleukin 1 beta	Homo sapiens	46-55
9316506-7	1997	Despite the marked increase in Bmax, however, IL-1 beta depressed adenosine 3",5"-cyclic monophosphate (cAMP) responses to isoproterenol and forskolin, a direct activator of AC (P &lt; 0.001 by analysis of variance for both).	Isoproterenol	123-136	interleukin 1 beta	Homo sapiens	46-55
9316506-7	1997	Despite the marked increase in Bmax, however, IL-1 beta depressed adenosine 3",5"-cyclic monophosphate (cAMP) responses to isoproterenol and forskolin, a direct activator of AC (P &lt; 0.001 by analysis of variance for both).	Colforsin	141-150	interleukin 1 beta	Homo sapiens	46-55
9316506-8	1997	The inhibitory effect of IL-1 beta on cAMP production appeared to be explained by increases in the activity of an inhibitory GTP binding protein because IL-1 beta treatment increased the activity of a pertussis toxin ADP-ribosylated Gi alpha protein by approximately 2.5-fold; and pretreatment of intact cells with pertussis toxin inhibited the effect of IL-1 beta on cAMP production.	Cyclic AMP	38-42	interleukin 1 beta	Homo sapiens	25-34
9316506-8	1997	The inhibitory effect of IL-1 beta on cAMP production appeared to be explained by increases in the activity of an inhibitory GTP binding protein because IL-1 beta treatment increased the activity of a pertussis toxin ADP-ribosylated Gi alpha protein by approximately 2.5-fold; and pretreatment of intact cells with pertussis toxin inhibited the effect of IL-1 beta on cAMP production.	Cyclic AMP	38-42	interleukin 1 beta	Homo sapiens	153-162
9322624-5	1997	RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta.	Dinoprostone	150-166	interleukin 1 beta	Homo sapiens	285-303
9316506-8	1997	The inhibitory effect of IL-1 beta on cAMP production appeared to be explained by increases in the activity of an inhibitory GTP binding protein because IL-1 beta treatment increased the activity of a pertussis toxin ADP-ribosylated Gi alpha protein by approximately 2.5-fold; and pretreatment of intact cells with pertussis toxin inhibited the effect of IL-1 beta on cAMP production.	Cyclic AMP	38-42	interleukin 1 beta	Homo sapiens	153-162
9322624-5	1997	RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta.	Dinoprost	171-193	interleukin 1 beta	Homo sapiens	75-93
9316506-8	1997	The inhibitory effect of IL-1 beta on cAMP production appeared to be explained by increases in the activity of an inhibitory GTP binding protein because IL-1 beta treatment increased the activity of a pertussis toxin ADP-ribosylated Gi alpha protein by approximately 2.5-fold; and pretreatment of intact cells with pertussis toxin inhibited the effect of IL-1 beta on cAMP production.	Guanosine Triphosphate	125-128	interleukin 1 beta	Homo sapiens	25-34
9316506-8	1997	The inhibitory effect of IL-1 beta on cAMP production appeared to be explained by increases in the activity of an inhibitory GTP binding protein because IL-1 beta treatment increased the activity of a pertussis toxin ADP-ribosylated Gi alpha protein by approximately 2.5-fold; and pretreatment of intact cells with pertussis toxin inhibited the effect of IL-1 beta on cAMP production.	Guanosine Triphosphate	125-128	interleukin 1 beta	Homo sapiens	153-162
9316506-8	1997	The inhibitory effect of IL-1 beta on cAMP production appeared to be explained by increases in the activity of an inhibitory GTP binding protein because IL-1 beta treatment increased the activity of a pertussis toxin ADP-ribosylated Gi alpha protein by approximately 2.5-fold; and pretreatment of intact cells with pertussis toxin inhibited the effect of IL-1 beta on cAMP production.	Guanosine Triphosphate	125-128	interleukin 1 beta	Homo sapiens	153-162
9316506-8	1997	The inhibitory effect of IL-1 beta on cAMP production appeared to be explained by increases in the activity of an inhibitory GTP binding protein because IL-1 beta treatment increased the activity of a pertussis toxin ADP-ribosylated Gi alpha protein by approximately 2.5-fold; and pretreatment of intact cells with pertussis toxin inhibited the effect of IL-1 beta on cAMP production.	Cyclic AMP	368-372	interleukin 1 beta	Homo sapiens	25-34
9322624-5	1997	RESULTS: When endometrial cells were incubated with interleukin-1 alpha or interleukin-1 beta, each cytokine was shown to stimulate the production of prostaglandin E2 and prostaglandin F2 alpha in a time- and dose-dependent fashion, with interleukin-1 alpha being far more potent than interleukin-1 beta.	Dinoprost	171-193	interleukin 1 beta	Homo sapiens	285-303
9322624-6	1997	Interleukin-1 receptor antagonist inhibited interleukin-1 alpha- and interleukin-1 beta-induced prostaglandin formation, with 50% inhibitory concentration values of 30 ng/ml for prostaglandin E2 and 90 ng/ml for prostaglandin F2 alpha.	Prostaglandins	96-109	interleukin 1 beta	Homo sapiens	0-87
9322624-6	1997	Interleukin-1 receptor antagonist inhibited interleukin-1 alpha- and interleukin-1 beta-induced prostaglandin formation, with 50% inhibitory concentration values of 30 ng/ml for prostaglandin E2 and 90 ng/ml for prostaglandin F2 alpha.	Dinoprost	212-234	interleukin 1 beta	Homo sapiens	0-87
9327757-7	1997	Inclusion of interleukin-1 beta in the culture medium increased the release of prostanoids by the saphenous vein but not by the internal mammary artery.	Prostaglandins	79-90	interleukin 1 beta	Homo sapiens	13-31
9316506-8	1997	The inhibitory effect of IL-1 beta on cAMP production appeared to be explained by increases in the activity of an inhibitory GTP binding protein because IL-1 beta treatment increased the activity of a pertussis toxin ADP-ribosylated Gi alpha protein by approximately 2.5-fold; and pretreatment of intact cells with pertussis toxin inhibited the effect of IL-1 beta on cAMP production.	Cyclic AMP	368-372	interleukin 1 beta	Homo sapiens	153-162
9316506-8	1997	The inhibitory effect of IL-1 beta on cAMP production appeared to be explained by increases in the activity of an inhibitory GTP binding protein because IL-1 beta treatment increased the activity of a pertussis toxin ADP-ribosylated Gi alpha protein by approximately 2.5-fold; and pretreatment of intact cells with pertussis toxin inhibited the effect of IL-1 beta on cAMP production.	Cyclic AMP	368-372	interleukin 1 beta	Homo sapiens	153-162
9316506-9	1997	These data indicate that IL-1 beta-mediated changes in the beta AR-AC system function in airway epithelial cells are complex and involve expression of receptor protein, GTP binding protein, and possibly AC itself.	Guanosine Triphosphate	169-172	interleukin 1 beta	Homo sapiens	25-34
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	110-119
9275047-6	1997	Interleukin-1beta (IL-1beta) elevated Cox-2 mRNA steady state levels in a concentration-dependent manner, and kinetic studies showed that Cox-2 mRNA levels were already induced at the 2 h point and returned to the basal level after incubation for 24 h. The protein synthesis inhibitor, cycloheximide, induced Cox-2 mRNA expression and potentiated the effect of IL-1beta.	Cycloheximide	286-299	interleukin 1 beta	Homo sapiens	0-17
9275047-6	1997	Interleukin-1beta (IL-1beta) elevated Cox-2 mRNA steady state levels in a concentration-dependent manner, and kinetic studies showed that Cox-2 mRNA levels were already induced at the 2 h point and returned to the basal level after incubation for 24 h. The protein synthesis inhibitor, cycloheximide, induced Cox-2 mRNA expression and potentiated the effect of IL-1beta.	Cycloheximide	286-299	interleukin 1 beta	Homo sapiens	19-27
9275047-9	1997	Further, IL-1beta-induced synthesis of prostanoids was blocked by a Cox-2-specific inhibitor, NS-398.	Prostaglandins	39-50	interleukin 1 beta	Homo sapiens	9-17
9275047-9	1997	Further, IL-1beta-induced synthesis of prostanoids was blocked by a Cox-2-specific inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	94-100	interleukin 1 beta	Homo sapiens	9-17
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Norepinephrine	18-31	interleukin 1 beta	Homo sapiens	110-119
9322065-4	1997	In peripheral blood mononuclear cells from 10 healthy donors, L-OspA at 10 micrograms ml-1 induced up to 4-fold more IL-1 beta, IL-6, and TNF-alpha than the other OspA preparations (P &lt; or = 0.0068), followed by NS1-OspA, which was still superior to NL-OspA.	l-ospa	62-68	interleukin 1 beta	Homo sapiens	117-126
9305751-6	1997	IL-1beta increased 12S-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) production (4-fold) and we also observed an increase in 12-HETE production (2.5-fold) after incubation of human RA type B synoviocytes with TNF alpha.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	19-62	interleukin 1 beta	Homo sapiens	0-8
9305751-6	1997	IL-1beta increased 12S-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) production (4-fold) and we also observed an increase in 12-HETE production (2.5-fold) after incubation of human RA type B synoviocytes with TNF alpha.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	64-71	interleukin 1 beta	Homo sapiens	0-8
9305751-7	1997	In contrast to the action of IL-1beta on 12-HETE synthesis, IL-4 and IL-6 did not enhance 12-HETE production.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	41-48	interleukin 1 beta	Homo sapiens	29-37
9322065-4	1997	In peripheral blood mononuclear cells from 10 healthy donors, L-OspA at 10 micrograms ml-1 induced up to 4-fold more IL-1 beta, IL-6, and TNF-alpha than the other OspA preparations (P &lt; or = 0.0068), followed by NS1-OspA, which was still superior to NL-OspA.	ospa	64-68	interleukin 1 beta	Homo sapiens	117-126
9307240-3	1997	Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammatory mediators zymosan, phorbol myristate acetate (PMA), lipopolysaccharide, interferon-gamma, tumor-necrosis factor-alpha and interleukin-1beta.	Glutamic Acid	53-62	interleukin 1 beta	Homo sapiens	246-263
9284101-7	1997	The main soluble fraction in the keratinocyte-conditioned medium contained a precursor of interleukin-1 alpha (proIL-1alpha) by western blot analysis, and PGE2 production was inhibited by anti-IL-1alpha antibody, but not by anti-IL-1beta or by anti-tumor necrosis factor-alpha antibody.	Dinoprostone	155-159	interleukin 1 beta	Homo sapiens	229-237
9352145-6	1997	Responders (CR + PR) showed significantly lower serum levels of TNF-alpha than non-responders (21.6 +/- 26.2 vs 106.3 +/- 60.8 ng/l, P &lt; 0.001), whereas IL-1 beta concentrations between those who benefited from therapy and unresponsive cases were not significantly different (39.8 +/- 48.9 vs 73.4 +/- 48.2 ng/l, P = 0.120).	cr + pr	12-19	interleukin 1 beta	Homo sapiens	156-165
9299361-5	1997	ANP, BNP and 8-bromo-cGMP, but not C-type natriuretic peptide (CNP), augmented NO synthesis in IL-1beta-stimulated cardiac myocytes in dose- and time-dependent manners.	8-bromocyclic GMP	13-25	interleukin 1 beta	Homo sapiens	95-103
9299361-7	1997	Simultaneous incubation with IL-1beta in the presence of the NOS inhibitor NG-monomethyl-l-arginine or the RNA synthesis inhibitor actinomycin D for 24 h completely inhibited ANP- and BNP- as well as IL-1beta-induced nitrite production.	omega-N-Methylarginine	75-99	interleukin 1 beta	Homo sapiens	29-37
9299361-7	1997	Simultaneous incubation with IL-1beta in the presence of the NOS inhibitor NG-monomethyl-l-arginine or the RNA synthesis inhibitor actinomycin D for 24 h completely inhibited ANP- and BNP- as well as IL-1beta-induced nitrite production.	omega-N-Methylarginine	75-99	interleukin 1 beta	Homo sapiens	200-208
9299361-7	1997	Simultaneous incubation with IL-1beta in the presence of the NOS inhibitor NG-monomethyl-l-arginine or the RNA synthesis inhibitor actinomycin D for 24 h completely inhibited ANP- and BNP- as well as IL-1beta-induced nitrite production.	Dactinomycin	131-144	interleukin 1 beta	Homo sapiens	29-37
9299361-7	1997	Simultaneous incubation with IL-1beta in the presence of the NOS inhibitor NG-monomethyl-l-arginine or the RNA synthesis inhibitor actinomycin D for 24 h completely inhibited ANP- and BNP- as well as IL-1beta-induced nitrite production.	Dactinomycin	131-144	interleukin 1 beta	Homo sapiens	200-208
9299361-7	1997	Simultaneous incubation with IL-1beta in the presence of the NOS inhibitor NG-monomethyl-l-arginine or the RNA synthesis inhibitor actinomycin D for 24 h completely inhibited ANP- and BNP- as well as IL-1beta-induced nitrite production.	Nitrites	217-224	interleukin 1 beta	Homo sapiens	29-37
9264555-3	1997	Treatment with IL-1beta or RA each resulted in &gt;90% GAG loss after 8 days in culture.	Glycosaminoglycans	55-58	interleukin 1 beta	Homo sapiens	15-23
9303000-1	1997	The folding of the beta-sheet protein, interleukin-1 beta, was examined at pH 5.0 and 25 degrees C using pulse-labelling hydrogen exchange and electrospray ionization mass spectrometric analysis, as well as stopped-flow circular dichroism and fluorescence spectroscopies.	Hydrogen	121-129	interleukin 1 beta	Homo sapiens	39-57
9305807-1	1997	We have investigated the roles of interleukin-1beta as a regulator of progesterone and chorionic gonadotrophin production from human placental cells.	Progesterone	70-82	interleukin 1 beta	Homo sapiens	34-51
9305807-2	1997	In primary placental cells IL-1beta increased hCG synthesis through a cyclic AMP-independent pathway, and was without effect on progesterone or cyclic AMP production.	Cyclic AMP	70-80	interleukin 1 beta	Homo sapiens	27-35
9305807-4	1997	Immortalised trophoblast cells responded to IL-1beta by increasing progesterone production through a cyclic AMP-dependent mechanism, but hCG production by these cells was unaffected by IL-1beta or dibutyryl cyclic AMP.	Progesterone	67-79	interleukin 1 beta	Homo sapiens	44-52
9305807-4	1997	Immortalised trophoblast cells responded to IL-1beta by increasing progesterone production through a cyclic AMP-dependent mechanism, but hCG production by these cells was unaffected by IL-1beta or dibutyryl cyclic AMP.	Cyclic AMP	101-111	interleukin 1 beta	Homo sapiens	44-52
9305807-5	1997	Further studies are needed to identify the role of IL-1beta as a possible regulator of progesterone production in primary placental cells.	Progesterone	87-99	interleukin 1 beta	Homo sapiens	51-59
9264555-4	1997	Addition of TIMP or L-758,354 to the culture media inhibited IL-1beta-induced loss of tissue GAG by 40 and 65%, respectively, and inhibited RA-induced GAG loss by 35 and 65%, respectively.	l-758	20-25	interleukin 1 beta	Homo sapiens	61-69
9264555-4	1997	Addition of TIMP or L-758,354 to the culture media inhibited IL-1beta-induced loss of tissue GAG by 40 and 65%, respectively, and inhibited RA-induced GAG loss by 35 and 65%, respectively.	Glycosaminoglycans	93-96	interleukin 1 beta	Homo sapiens	61-69
9264555-7	1997	Both IL-1beta and RA induced significant loss of hyaluronan from cartilage explants after 8 days of exposure and HA loss was also inhibited by addition of L-756,354 to the culture media.	Hyaluronic Acid	49-59	interleukin 1 beta	Homo sapiens	5-13
9264555-8	1997	IL-1beta, but not RA, induced a significant increase in swelling ratio (wet weight in 0.01 M NaCl normalized to wet weight in DMEM) after 8 days in culture, consistent with degradation of the collagen network, and the increase in tissue swelling was inhibited by treatment with TIMP-1 or L-758,354.	Sodium Chloride	93-97	interleukin 1 beta	Homo sapiens	0-8
9264555-8	1997	IL-1beta, but not RA, induced a significant increase in swelling ratio (wet weight in 0.01 M NaCl normalized to wet weight in DMEM) after 8 days in culture, consistent with degradation of the collagen network, and the increase in tissue swelling was inhibited by treatment with TIMP-1 or L-758,354.	dmem	126-130	interleukin 1 beta	Homo sapiens	0-8
9266823-2	1997	Interleukin-1beta (IL-1beta) treatment of type II A549 cells increases PGE2 synthesis via transcription- and translation-dependent induction of COX-2.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	0-17
9266823-2	1997	Interleukin-1beta (IL-1beta) treatment of type II A549 cells increases PGE2 synthesis via transcription- and translation-dependent induction of COX-2.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	19-27
9266823-7	1997	We conclude that IL-1beta stimulates PG production via transcriptional activation of COX-2 and provide evidence that this may involve NF-kappaB.	Prostaglandins	37-39	interleukin 1 beta	Homo sapiens	17-25
9277478-8	1997	TCP succinate (20 microM, 72 h), but not TCP (200 microM, 72 h), reduced U-937 cell adhesion to TNF-alpha-stimulated (10 U/ml, 6 h) HUVEC by 30% (P &lt; 0.025) and to IL-1 beta-stimulated HUVEC by 56% (P &lt; 0.010).	alpha-Tocopherol	0-3	interleukin 1 beta	Homo sapiens	167-176
9301635-12	1997	A23187 also abolished the increase in PAI-1 synthesis induced by recombinant human interleukin 1 beta, and thapsigargin exerted effects comparable to those of A23187 on PAI-1 synthesis in TNF-stimulated cells.	Calcimycin	0-6	interleukin 1 beta	Homo sapiens	83-101
9257931-16	1997	Cells incubated with IL-1beta 3 u ml(-1) for 6 h, either alone or with addition of the NO donor S-nitroso-acetyl-penicillamine (SNAP) (0 to 10(-4) M), demonstrated increased PGE2 formation (1.23 +/- 0.03 to 2.92 +/- 0.19 pg/10(4) cells; P&lt; 0.05).	S-Nitroso-N-Acetylpenicillamine	96-126	interleukin 1 beta	Homo sapiens	21-29
9257931-19	1997	Cells incubated with IL-1beta 3 u ml(-1) for 6 h in the presence of dibutyryl cyclic guanylate monophosphate (0 to 10(-3) M) also demonstrated an increased PGE2 response (2.56 +/- 0.21 to 4.53 +/- 0.64 pg/10(4) cells; P&lt;0.05).	dibutyryl cyclic guanylate monophosphate	68-108	interleukin 1 beta	Homo sapiens	21-29
9257931-10	1997	IL-1beta alone (1-50 u ml(-1) induced PGE2 formation without significant nitrite formation, a response which was inhibited by the COX-2 specific inhibitor nimesulide.	Dinoprostone	38-42	interleukin 1 beta	Homo sapiens	0-8
9257931-10	1997	IL-1beta alone (1-50 u ml(-1) induced PGE2 formation without significant nitrite formation, a response which was inhibited by the COX-2 specific inhibitor nimesulide.	nimesulide	155-165	interleukin 1 beta	Homo sapiens	0-8
9257931-19	1997	Cells incubated with IL-1beta 3 u ml(-1) for 6 h in the presence of dibutyryl cyclic guanylate monophosphate (0 to 10(-3) M) also demonstrated an increased PGE2 response (2.56 +/- 0.21 to 4.53 +/- 0.64 pg/10(4) cells; P&lt;0.05).	Dinoprostone	156-160	interleukin 1 beta	Homo sapiens	21-29
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	59-68
9297577-5	1997	RESULTS: RhIL-1 beta augments the production of TIMP-1 and proMMP-1 in synovial fibroblasts from RA patients, and this IL-1-induced production of TIMP-1 and proMMP-1 was further enhanced by treatment with the cyclooxygenase inhibitors, indomethacin and diclofenac.	Indomethacin	236-248	interleukin 1 beta	Homo sapiens	11-15
9315475-11	1997	Similar concurrent suppression of IL-1 beta and IL-1ra release occurred in PBMC and Mono Mac 6 cultures exposed to dexamethasone.	Dexamethasone	115-128	interleukin 1 beta	Homo sapiens	34-43
9378493-6	1997	LPS-induced TNF-alpha and IL-1 beta production in whole blood was inhibited by dexamethasone treatment, while chlorpromazine had no effect.	Dexamethasone	79-92	interleukin 1 beta	Homo sapiens	26-35
9297577-5	1997	RESULTS: RhIL-1 beta augments the production of TIMP-1 and proMMP-1 in synovial fibroblasts from RA patients, and this IL-1-induced production of TIMP-1 and proMMP-1 was further enhanced by treatment with the cyclooxygenase inhibitors, indomethacin and diclofenac.	Diclofenac	253-263	interleukin 1 beta	Homo sapiens	11-15
9261337-0	1997	Human monocyte ATP-induced IL-1 beta posttranslational processing is a dynamic process dependent on in vitro growth conditions.	Adenosine Triphosphate	15-18	interleukin 1 beta	Homo sapiens	27-36
9233643-1	1997	Extracellular ATP (ATPe) is known to cause release of processed IL-1 beta from LPS-treated macrophages and microglial cells.	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	64-73
9233643-4	1997	Our data confirm that ATPe is a powerful stimulus for IL-1 beta release from LPS-treated human macrophages; however, we also show that IL-1 beta release is not necessarily associated with cell death, as it occurs at lower ATP concentrations and much earlier than leakage of cytoplasmic markers.	Adenosine Triphosphate	22-25	interleukin 1 beta	Homo sapiens	54-63
9233643-7	1997	The irreversible P2Z blocker-oxidized ATP completely inhibited ATPe-induced IL-1 beta release.	Adenosine Triphosphate	38-41	interleukin 1 beta	Homo sapiens	76-85
9233643-0	1997	Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages.	Adenosine Triphosphate	14-17	interleukin 1 beta	Homo sapiens	27-36
9261337-4	1997	The ability of monocytes to produce radiolabeled pro-IL-1 beta in response to LPS and to posttranslationally process the procytokine after ATP stimulation was affected both by time in culture and by the presence of specific media components.	Adenosine Triphosphate	139-142	interleukin 1 beta	Homo sapiens	49-62
9261337-5	1997	These observations indicate that ATP"s ability to promote human monocyte IL-1 beta posttranslational processing is a dynamic process that is subject to regulation by cytokines and/or growth factors.	Adenosine Triphosphate	33-36	interleukin 1 beta	Homo sapiens	73-82
9263137-3	1997	RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected.	Gold Sodium Thiomalate	64-68	interleukin 1 beta	Homo sapiens	160-169
9263137-3	1997	RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected.	Dinoprostone	74-78	interleukin 1 beta	Homo sapiens	160-169
9263137-3	1997	RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected.	Dexamethasone	49-62	interleukin 1 beta	Homo sapiens	160-169
9218603-5	1997	CD40 signaling of IL-1beta synthesis was shown to be dependent on the induction of protein tyrosine kinase (PTK) activity, and both IL-4 and IL-10 diminished CD40-mediated tyrosine phosphorylation of monocyte cellular proteins.	Tyrosine	91-99	interleukin 1 beta	Homo sapiens	18-26
9266806-8	1997	Acrolein caused a dose-dependent inhibition of release of IL-1beta, TNF-alpha, and IL-12.	Acrolein	0-8	interleukin 1 beta	Homo sapiens	58-66
9221748-0	1997	Tumor necrosis factor alpha and interleukin 1beta enhance the cortisone/cortisol shuttle.	Cortisone	62-71	interleukin 1 beta	Homo sapiens	32-49
9221748-0	1997	Tumor necrosis factor alpha and interleukin 1beta enhance the cortisone/cortisol shuttle.	Hydrocortisone	72-80	interleukin 1 beta	Homo sapiens	32-49
9221748-9	1997	Similarly, this IL-1beta- and TNF-alpha-induced formation of active 11beta-hydroxy glucocorticosteroids from inert 11-keto glucocorticosteroids by the 11beta-OHSD1 was shown in the Kiki cell line that expresses the stably transfected bacterial beta-galactosidase gene under the control of a glucocorticosteroids response element.	11beta-hydroxy glucocorticosteroids	68-103	interleukin 1 beta	Homo sapiens	16-24
9221748-9	1997	Similarly, this IL-1beta- and TNF-alpha-induced formation of active 11beta-hydroxy glucocorticosteroids from inert 11-keto glucocorticosteroids by the 11beta-OHSD1 was shown in the Kiki cell line that expresses the stably transfected bacterial beta-galactosidase gene under the control of a glucocorticosteroids response element.	glucocorticosteroids	83-103	interleukin 1 beta	Homo sapiens	16-24
9218566-0	1997	Dexamethasone potently enhances phorbol ester-induced IL-1beta gene expression and nuclear factor NF-kappaB activation.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	54-62
9274933-2	1997	Varying amounts of prostaglandin E2 were induced in WISH cells using either interleukin-1beta, tumor necrosis factor-alpha or phorbol 12-myristate 13-acetate, alone or in combination, or with okadaic acid as stimulants.	Dinoprostone	19-35	interleukin 1 beta	Homo sapiens	76-122
9218566-0	1997	Dexamethasone potently enhances phorbol ester-induced IL-1beta gene expression and nuclear factor NF-kappaB activation.	Phorbol Esters	32-45	interleukin 1 beta	Homo sapiens	54-62
9252519-4	1997	Dose-dependent inhibition of interleukin-1 beta- and interferon-gamma-stimulated nitrite/nitrate production was observed when cells were preincubated for 6 h with UDCA (0-800 microM), and a substantial inhibition (81 +/- 3.2%) was seen at 500 microM.	Nitrites	81-88	interleukin 1 beta	Homo sapiens	29-69
9218566-1	1997	The synthetic glucocorticoid dexamethasone, an immunosuppressive and anti-inflammatory agent, was investigated for its effect on PMA-mediated expression of the inflammatory cytokine IL-1beta in the human monocytic leukemic cell line THP-1.	Dexamethasone	29-42	interleukin 1 beta	Homo sapiens	182-190
9218566-2	1997	PMA alone induced the production of low levels of IL-1beta in THP-1 cells, whereas dexamethasone alone had no effect.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	50-58
9218566-3	1997	However, dexamethasone potently enhanced PMA-mediated IL-1beta production.	Dexamethasone	9-22	interleukin 1 beta	Homo sapiens	54-62
9218566-6	1997	Using an oligonucleotide probe corresponding to an NF-kappaB DNA-binding motif of the IL-1beta gene promoter in gel electrophoresis mobility shift assays, we demonstrated that PMA-induced NF-kappaB activation was greatly potentiated by dexamethasone.	Oligonucleotides	9-24	interleukin 1 beta	Homo sapiens	86-94
9218566-6	1997	Using an oligonucleotide probe corresponding to an NF-kappaB DNA-binding motif of the IL-1beta gene promoter in gel electrophoresis mobility shift assays, we demonstrated that PMA-induced NF-kappaB activation was greatly potentiated by dexamethasone.	Tetradecanoylphorbol Acetate	176-179	interleukin 1 beta	Homo sapiens	86-94
9218566-6	1997	Using an oligonucleotide probe corresponding to an NF-kappaB DNA-binding motif of the IL-1beta gene promoter in gel electrophoresis mobility shift assays, we demonstrated that PMA-induced NF-kappaB activation was greatly potentiated by dexamethasone.	Dexamethasone	236-249	interleukin 1 beta	Homo sapiens	86-94
9252519-4	1997	Dose-dependent inhibition of interleukin-1 beta- and interferon-gamma-stimulated nitrite/nitrate production was observed when cells were preincubated for 6 h with UDCA (0-800 microM), and a substantial inhibition (81 +/- 3.2%) was seen at 500 microM.	Nitrates	89-96	interleukin 1 beta	Homo sapiens	29-69
9237810-7	1997	Among different inhibitors of phosphorylation and dephosphorylation processes, only okadaic acid, an inhibitor of serine/threonine phosphatases, differentially modulates the production of IL-1beta and IL-1Ra.	Okadaic Acid	84-96	interleukin 1 beta	Homo sapiens	188-196
9214430-5	1997	RESULTS: Antisense oligonucleotides targeting PCNA inhibited IL-1-stimulated fibroblast proliferation, whereas sense oligonucleotides had no effect.	Oligonucleotides	19-35	interleukin 1 beta	Homo sapiens	61-65
9255105-4	1997	TGF beta 1 and TGF beta 2 were shown to modulate IL-1 beta-stimulated PGE production and caseinase activity.	Prostaglandins E	70-73	interleukin 1 beta	Homo sapiens	49-58
9255105-5	1997	Both TGF beta 1 and beta 2 inhibited IL-1 beta-stimulated PGE production in the absence of serum and augmented it in the presence of serum.	Prostaglandins E	58-61	interleukin 1 beta	Homo sapiens	37-46
9237810-8	1997	Indeed, okadaic acid upregulated IL-1beta and decreased IL-1Ra at the mRNA and protein level in monocytic cells activated by membranes of stimulated T cells.	Okadaic Acid	8-20	interleukin 1 beta	Homo sapiens	33-41
9179403-3	1997	IL-1 beta, TNF alpha and interferon-gamma (IFN gamma) are known to stimulate a number of cells to produce inflammatory mediators such as prostaglandins.	Prostaglandins	137-151	interleukin 1 beta	Homo sapiens	0-9
9252067-5	1997	RESULTS: The strongest interleukin-1beta immunostaining was observed in the above-described plasma cell population, identified by anti-immunoglobulin antibodies, and 3H-proline incorporation.	3h-proline	166-176	interleukin 1 beta	Homo sapiens	23-40
9256170-2	1997	IL-1beta enhanced PGE2 production in cultured fibroblasts.	Dinoprostone	18-22	interleukin 1 beta	Homo sapiens	0-8
9179403-8	1997	IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products.	Dinoprost	147-151	interleukin 1 beta	Homo sapiens	0-9
9179403-8	1997	IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products.	Thromboxane B2	159-173	interleukin 1 beta	Homo sapiens	0-9
9179403-8	1997	IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products.	Thromboxane B2	175-179	interleukin 1 beta	Homo sapiens	0-9
9266272-13	1997	In vitro 50-100 mumol/l of both drugs inhibited the activities of selected metallo-proteinases, but only doxycycline suppressed the generation of IL-1 beta/TNF alpha in human mononuclear cells, whereas tiaprofenic acid was virtually inactive in that model.	Doxycycline	105-116	interleukin 1 beta	Homo sapiens	146-155
9202299-3	1997	Calcitriol stimulated NGF secretion, whereas corticosterone reduced basal levels of NGF secretion as well as inhibited the NGF secretion induced by IL-1beta, calcitriol, and TGF-beta1.	Calcitriol	0-10	interleukin 1 beta	Homo sapiens	148-156
9202299-3	1997	Calcitriol stimulated NGF secretion, whereas corticosterone reduced basal levels of NGF secretion as well as inhibited the NGF secretion induced by IL-1beta, calcitriol, and TGF-beta1.	Corticosterone	45-59	interleukin 1 beta	Homo sapiens	148-156
9202299-4	1997	Calcitriol had an additive effect when applied together with IL-1beta and a synergistic effect when applied with TGF-beta1.	Calcitriol	0-10	interleukin 1 beta	Homo sapiens	61-69
9226412-3	1997	Aceclofenac inhibited interleukin-1beta-induced prostaglandin E2 production by human rheumatoid synovial cells, but had no inhibitory effect on cyclooxygenase-1 or cyclooxygenase-2 activities by itself.	aceclofenac	0-11	interleukin 1 beta	Homo sapiens	22-39
9226412-3	1997	Aceclofenac inhibited interleukin-1beta-induced prostaglandin E2 production by human rheumatoid synovial cells, but had no inhibitory effect on cyclooxygenase-1 or cyclooxygenase-2 activities by itself.	Dinoprostone	48-64	interleukin 1 beta	Homo sapiens	22-39
9185506-5	1997	Administration of dexamethasone to temporal artery-SCID chimeras for 1 wk induced a partial suppression of T cell and macrophage function as indicated by the reduced tissue concentrations of IL-2, IL-1beta, and IL-6 mRNA, and by the diminished expression of inducible NO synthase.	Dexamethasone	18-31	interleukin 1 beta	Homo sapiens	197-205
9191470-6	1997	Northern blot analyses demonstrated that IL-1 beta rapidly induces accumulation of u-PAR messenger RNA (mRNA) in a dose-dependent fashion, and that this effect is blocked by actinomycin.	Dactinomycin	174-185	interleukin 1 beta	Homo sapiens	41-50
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	125-171	interleukin 1 beta	Homo sapiens	4-13
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	173-175	interleukin 1 beta	Homo sapiens	4-13
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	calphostin C	181-193	interleukin 1 beta	Homo sapiens	4-13
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	Tetradecanoylphorbol Acetate	240-265	interleukin 1 beta	Homo sapiens	4-13
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	Tetradecanoylphorbol Acetate	267-270	interleukin 1 beta	Homo sapiens	4-13
9191470-8	1997	Okadaic acid, an inhibitor of serine/threonine phosphatases, markedly potentiates the effect of IL-1 beta on u-PAR mRNA levels.	Okadaic Acid	0-12	interleukin 1 beta	Homo sapiens	96-105
9191470-9	1997	In contrast, dexamethasone, in concentrations as low as 10(-8) M, completely blocks the IL-1 beta-mediated increase in u-PAR mRNA.	Dexamethasone	13-26	interleukin 1 beta	Homo sapiens	88-97
9191472-9	1997	IL-1 beta also significantly attenuated the ability of prostaglandin E2 (PGE2) to decrease cell stiffness.	Dinoprostone	55-71	interleukin 1 beta	Homo sapiens	0-9
9191472-9	1997	IL-1 beta also significantly attenuated the ability of prostaglandin E2 (PGE2) to decrease cell stiffness.	Dinoprostone	73-77	interleukin 1 beta	Homo sapiens	0-9
9191472-11	1997	IL-1 beta (20 ng/ml for 40 h) caused a small (30%) but significant (P &lt; 0.02) increase in basal cAMP, but also resulted in a 2-3-fold decrease in the changes in cAMP formation induced by either ISO or PGE2.	Cyclic AMP	99-103	interleukin 1 beta	Homo sapiens	0-9
9191472-11	1997	IL-1 beta (20 ng/ml for 40 h) caused a small (30%) but significant (P &lt; 0.02) increase in basal cAMP, but also resulted in a 2-3-fold decrease in the changes in cAMP formation induced by either ISO or PGE2.	Cyclic AMP	164-168	interleukin 1 beta	Homo sapiens	0-9
9191472-11	1997	IL-1 beta (20 ng/ml for 40 h) caused a small (30%) but significant (P &lt; 0.02) increase in basal cAMP, but also resulted in a 2-3-fold decrease in the changes in cAMP formation induced by either ISO or PGE2.	Isoproterenol	197-200	interleukin 1 beta	Homo sapiens	0-9
9191472-11	1997	IL-1 beta (20 ng/ml for 40 h) caused a small (30%) but significant (P &lt; 0.02) increase in basal cAMP, but also resulted in a 2-3-fold decrease in the changes in cAMP formation induced by either ISO or PGE2.	Dinoprostone	204-208	interleukin 1 beta	Homo sapiens	0-9
9230816-10	1997	Modulation of IL-1 beta and TNF-alpha receptors by VLA-5 and VLA-6 required protein tyrosine kinase activation as herbimycin A (10 micrograms/mL) blocked the affect of Fn and Ln.	herbimycin	114-126	interleukin 1 beta	Homo sapiens	14-23
9179403-8	1997	IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products.	Dinoprostone	101-105	interleukin 1 beta	Homo sapiens	0-9
9179403-8	1997	IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products.	Dinoprostone	208-212	interleukin 1 beta	Homo sapiens	0-9
9179403-8	1997	IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products.	6-keto-pgf1	217-228	interleukin 1 beta	Homo sapiens	0-9
9179403-14	1997	Pretreatment with the conventional non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, and the selective COX-2 inhibitors, NS-398 and nimesulide, completely blocked IL-1 beta-induced PGE2 release and COX activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	147-153	interleukin 1 beta	Homo sapiens	189-198
9179403-8	1997	IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products.	Prostaglandins	116-126	interleukin 1 beta	Homo sapiens	0-9
9179403-8	1997	IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products.	6-keto-pgf1	128-139	interleukin 1 beta	Homo sapiens	0-9
9186223-4	1997	Titanium, cobalt, and chromium at concentrations ranging from 0.01 to 100 ng/ml significantly enhanced the release of interleukin-1 beta and tumor necrosis factor-alpha by lipopolysaccharide stimulated human osteogenic sarcoma cells, whereas they did not alter the release of transforming growth factor-beta 1.	Titanium	0-8	interleukin 1 beta	Homo sapiens	118-168
9179403-14	1997	Pretreatment with the conventional non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, and the selective COX-2 inhibitors, NS-398 and nimesulide, completely blocked IL-1 beta-induced PGE2 release and COX activity.	nimesulide	158-168	interleukin 1 beta	Homo sapiens	189-198
9179403-14	1997	Pretreatment with the conventional non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, and the selective COX-2 inhibitors, NS-398 and nimesulide, completely blocked IL-1 beta-induced PGE2 release and COX activity.	Dinoprostone	207-211	interleukin 1 beta	Homo sapiens	189-198
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	glucocorticosteroid	4-23	interleukin 1 beta	Homo sapiens	133-142
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	glucocorticosteroid	4-23	interleukin 1 beta	Homo sapiens	204-213
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Dexamethasone	24-37	interleukin 1 beta	Homo sapiens	133-142
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Dexamethasone	24-37	interleukin 1 beta	Homo sapiens	204-213
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Cycloheximide	72-85	interleukin 1 beta	Homo sapiens	133-142
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Cycloheximide	72-85	interleukin 1 beta	Homo sapiens	204-213
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Dactinomycin	90-103	interleukin 1 beta	Homo sapiens	133-142
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Dactinomycin	90-103	interleukin 1 beta	Homo sapiens	204-213
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Dinoprostone	154-158	interleukin 1 beta	Homo sapiens	133-142
9179403-17	1997	This study demonstrates that human cultured ASM cells release prostanoids in response to IL-1 beta stimulation and that the response is mostly mediated by the induction of COX-2 rather than COX-1 isoenzyme, implying that airway smooth muscle may be an important source of prostaglandins in human airways and that COX-2 may play an important role in the regulation of the inflammatory process in asthma.	Prostaglandins	62-73	interleukin 1 beta	Homo sapiens	89-98
9224565-2	1997	Pyridinylimidazole compounds are specific inhibitors of p38 MAP kinase that block the production of the cytokines interleukin-1beta and tumor necrosis factor alpha, and they are effective in animal models of arthritis, bone resorption and endotoxin shock.	CHEMBL96741	0-18	interleukin 1 beta	Homo sapiens	114-163
9186223-4	1997	Titanium, cobalt, and chromium at concentrations ranging from 0.01 to 100 ng/ml significantly enhanced the release of interleukin-1 beta and tumor necrosis factor-alpha by lipopolysaccharide stimulated human osteogenic sarcoma cells, whereas they did not alter the release of transforming growth factor-beta 1.	Cobalt	10-16	interleukin 1 beta	Homo sapiens	118-168
9186223-4	1997	Titanium, cobalt, and chromium at concentrations ranging from 0.01 to 100 ng/ml significantly enhanced the release of interleukin-1 beta and tumor necrosis factor-alpha by lipopolysaccharide stimulated human osteogenic sarcoma cells, whereas they did not alter the release of transforming growth factor-beta 1.	Chromium	22-30	interleukin 1 beta	Homo sapiens	118-168
9164976-5	1997	In addition, Dex had additive but not synergistic effects on stimulation of KS cell growth with IL-1beta or TNF-alpha, the signals of which are not mediated through gp130.	Dexamethasone	13-16	interleukin 1 beta	Homo sapiens	96-104
9138096-8	1997	Cyclic AMP mimetics and PKA activators, IBMX, and Sp-cAMP, inhibited the expression of the binding protein as did the PGE2 secretagogue, interleukin-1 beta (IL-beta).	Cyclic AMP	0-10	interleukin 1 beta	Homo sapiens	137-155
9138096-8	1997	Cyclic AMP mimetics and PKA activators, IBMX, and Sp-cAMP, inhibited the expression of the binding protein as did the PGE2 secretagogue, interleukin-1 beta (IL-beta).	1-Methyl-3-isobutylxanthine	40-44	interleukin 1 beta	Homo sapiens	137-155
9138096-8	1997	Cyclic AMP mimetics and PKA activators, IBMX, and Sp-cAMP, inhibited the expression of the binding protein as did the PGE2 secretagogue, interleukin-1 beta (IL-beta).	adenosine-3',5'-cyclic phosphorothioate	50-57	interleukin 1 beta	Homo sapiens	137-155
9138096-8	1997	Cyclic AMP mimetics and PKA activators, IBMX, and Sp-cAMP, inhibited the expression of the binding protein as did the PGE2 secretagogue, interleukin-1 beta (IL-beta).	Dinoprostone	118-122	interleukin 1 beta	Homo sapiens	137-155
9234165-1	1997	We examined the effects of nine flavonoids isolated from Scutellariae radix on interleukin-1 beta (IL-1 beta)- and tumor necrosis factor-alpha (TNF-alpha)-induced adhesion molecule expression in cultured human umbilical vein endothelial cells (HUVECs).	Flavonoids	32-42	interleukin 1 beta	Homo sapiens	79-97
9219348-2	1997	Both acids, derived by lipid peroxidation of linoleic acid, induce the release of interleukin 1 beta.	Linoleic Acid	45-58	interleukin 1 beta	Homo sapiens	82-100
9234165-1	1997	We examined the effects of nine flavonoids isolated from Scutellariae radix on interleukin-1 beta (IL-1 beta)- and tumor necrosis factor-alpha (TNF-alpha)-induced adhesion molecule expression in cultured human umbilical vein endothelial cells (HUVECs).	Flavonoids	32-42	interleukin 1 beta	Homo sapiens	99-108
9234165-2	1997	Among them, we found that baicalein (5,6,7-trihydroxy flavone) dose-dependently inhibited IL-1 beta and TNF-alpha-induced endothelial leukocyte adhesion molecule-1 (ELAM-1) and intercellular adhesion molecule-1 (ICAM-1) expressions.	baicalein	26-35	interleukin 1 beta	Homo sapiens	90-99
9234165-2	1997	Among them, we found that baicalein (5,6,7-trihydroxy flavone) dose-dependently inhibited IL-1 beta and TNF-alpha-induced endothelial leukocyte adhesion molecule-1 (ELAM-1) and intercellular adhesion molecule-1 (ICAM-1) expressions.	baicalein	37-61	interleukin 1 beta	Homo sapiens	90-99
9184651-6	1997	The increase in surface expression of ICAM-1 and neutrophil adhesion by IL-1 beta, TPA and ischemia were significantly reduced by the cyclo-oxygenase (COX) inhibitors, indomethacin (100-300 microM) and dexamethasone (10-50 microM).	Dexamethasone	202-215	interleukin 1 beta	Homo sapiens	72-81
9184656-2	1997	Abundant IL-1 beta immunoreactivities, corresponding to both pro IL-1 beta and mature IL-1 beta as assessed by immunoblotting, were observed in all diseased muscles, either in inflammatory cells (sarcoid myopathy) or in atrophic muscle fibers (AZT myopathy).	Zidovudine	244-247	interleukin 1 beta	Homo sapiens	9-18
9184656-3	1997	Acid guanidinium isothiocyanate phenol-chloroform extraction of RNA appeared less efficient for IL-1 beta mRNA detection by RT-PCR than proteinase K digestion followed by phenol-chloroform extraction.	acid guanidinium isothiocyanate	0-31	interleukin 1 beta	Homo sapiens	96-105
9184656-3	1997	Acid guanidinium isothiocyanate phenol-chloroform extraction of RNA appeared less efficient for IL-1 beta mRNA detection by RT-PCR than proteinase K digestion followed by phenol-chloroform extraction.	Phenol	32-38	interleukin 1 beta	Homo sapiens	96-105
9184656-3	1997	Acid guanidinium isothiocyanate phenol-chloroform extraction of RNA appeared less efficient for IL-1 beta mRNA detection by RT-PCR than proteinase K digestion followed by phenol-chloroform extraction.	Chloroform	39-49	interleukin 1 beta	Homo sapiens	96-105
9184656-5	1997	Semi-quantitative PCR showed that production of IL-1 beta mRNA was higher in sarcoid myopathy than in AZT myopathy, and in AZT myopathy than in controls.	Zidovudine	102-105	interleukin 1 beta	Homo sapiens	48-57
9184656-5	1997	Semi-quantitative PCR showed that production of IL-1 beta mRNA was higher in sarcoid myopathy than in AZT myopathy, and in AZT myopathy than in controls.	Zidovudine	123-126	interleukin 1 beta	Homo sapiens	48-57
9256609-10	1997	Prednisolone inhibited the production of IL-1 alpha, IL-1 beta, IL-6 and TNF alpha.	Prednisolone	0-12	interleukin 1 beta	Homo sapiens	53-62
9184648-4	1997	Linomide strongly suppressed IFN-gamma and lipopolysaccharide (LPS)-induced IL-1 beta, TNF-alpha and IL-6 mRNA expression in macrophages in vitro as demonstrated by in situ hybridisation.	roquinimex	0-8	interleukin 1 beta	Homo sapiens	76-85
9184651-4	1997	Both IL-1 beta- and TPA-induced expression of ICAM-1 and increased neutrophil adhesion to HCEC were inhibited by the transcriptional inhibitor, actinomycin D (AcD; 1-10 micrograms/ml), and by an anti-ICAM-1 antibody (ICAM-1 Ab).	Dactinomycin	144-157	interleukin 1 beta	Homo sapiens	5-14
9184651-4	1997	Both IL-1 beta- and TPA-induced expression of ICAM-1 and increased neutrophil adhesion to HCEC were inhibited by the transcriptional inhibitor, actinomycin D (AcD; 1-10 micrograms/ml), and by an anti-ICAM-1 antibody (ICAM-1 Ab).	Dactinomycin	159-162	interleukin 1 beta	Homo sapiens	5-14
9184651-6	1997	The increase in surface expression of ICAM-1 and neutrophil adhesion by IL-1 beta, TPA and ischemia were significantly reduced by the cyclo-oxygenase (COX) inhibitors, indomethacin (100-300 microM) and dexamethasone (10-50 microM).	Indomethacin	168-180	interleukin 1 beta	Homo sapiens	72-81
9210549-5	1997	To test the hypothesis that percussive trauma increases the production of TNF-alpha and IL-1beta by HCME, serial supernatant samples from passage 2 HCME were collected for 24 hours and analyzed for TNF-alpha and IL-1beta concentration by enzyme-linked immunosorbent assay after trauma.	hcme	100-104	interleukin 1 beta	Homo sapiens	88-96
9187256-7	1997	Sodium salicylate inhibited prostaglandin E2 release when added together with interleukin 1beta for 24 hr with an IC50 value of 5 microg/ml, an effect that was independent of NF-kappaB activation or COX-2 transcription or translation.	Sodium Salicylate	0-17	interleukin 1 beta	Homo sapiens	78-95
9187256-7	1997	Sodium salicylate inhibited prostaglandin E2 release when added together with interleukin 1beta for 24 hr with an IC50 value of 5 microg/ml, an effect that was independent of NF-kappaB activation or COX-2 transcription or translation.	Dinoprostone	28-44	interleukin 1 beta	Homo sapiens	78-95
9225602-4	1997	Celosian also induced the production of interleukin-1 beta (IL-1 beta) and nitric oxide (NO) in macrophage cell line J774.1 in a concentration-dependent manner (1 to 1000 micrograms/ml).	celosian	0-8	interleukin 1 beta	Homo sapiens	60-69
9225602-5	1997	Moreover, celosian induced IL-1 beta secretion in human mononuclear cells.	celosian	10-18	interleukin 1 beta	Homo sapiens	27-36
9185243-4	1997	In human peripheral blood mononuclear cells stimulated in vitro with 1 microgram/mL endotoxin, GM-6001 at concentrations &gt; 5 micrograms/mL blocked release of TNF alpha, but did not affect the release of either IL-1 beta or IL-6.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	95-102	interleukin 1 beta	Homo sapiens	213-222
9160463-13	1997	RESULTS: Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2 in response to interleukin-1 beta.	Nitric Oxide	111-123	interleukin 1 beta	Homo sapiens	176-194
9144511-6	1997	However, suppression of PGHS-2 expression is not the result of suppressed cytokine production, because SK&amp;F 86002 suppressed PGHS-2 expression initiated by IL-1beta and TNF-alpha, in addition to other stimuli.	amicloral	103-109	interleukin 1 beta	Homo sapiens	160-168
9160463-13	1997	RESULTS: Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2 in response to interleukin-1 beta.	Dinoprostone	144-160	interleukin 1 beta	Homo sapiens	176-194
9164871-2	1997	NG-Monomethyl-l-arginine (L-NMA), an inhibitor of NO synthase, strongly suppressed the production of NO and partially relieved the inhibition of collagen synthesis in response to IL-1beta.	omega-N-Methylarginine	0-24	interleukin 1 beta	Homo sapiens	179-187
9160463-14	1997	Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide, interleukin-6, and prostaglandin E2 in response to interleukin-1 beta.	Nitric Oxide	156-168	interleukin 1 beta	Homo sapiens	221-239
9164871-2	1997	NG-Monomethyl-l-arginine (L-NMA), an inhibitor of NO synthase, strongly suppressed the production of NO and partially relieved the inhibition of collagen synthesis in response to IL-1beta.	l-nma	26-31	interleukin 1 beta	Homo sapiens	179-187
9160463-14	1997	Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide, interleukin-6, and prostaglandin E2 in response to interleukin-1 beta.	Dinoprostone	189-205	interleukin 1 beta	Homo sapiens	221-239
9164871-8	1997	Extracts of cells treated with IL-1 or SNAP had lower prolyl hydroxylase activity, and L-NMA was partially able to reverse the effects of IL-1.	l-nma	87-92	interleukin 1 beta	Homo sapiens	138-142
9160463-15	1997	Blocking the biosynthesis of nitric oxide in interleukin-1 beta-stimulated disc cells provoked a large increase in the production of interleukin-6.	Nitric Oxide	29-41	interleukin 1 beta	Homo sapiens	45-63
9160463-16	1997	CONCLUSIONS: Cells of the intervertebral discs are biologically responsive and increase their production of matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2 when stimulated by interleukin-1 beta.	Dinoprostone	168-184	interleukin 1 beta	Homo sapiens	204-222
9154324-11	1997	Both PMA and IL-1 beta produced dose- and time-dependent increases of the synthesis of the COX-derived eicosanoids.	Eicosanoids	103-114	interleukin 1 beta	Homo sapiens	13-22
9191294-0	1997	Induction of TNF alpha and IL-1 beta mRNA in monocytes by methylglyoxal- and advanced glycated endproduct-modified human serum albumin.	Pyruvaldehyde	58-71	interleukin 1 beta	Homo sapiens	27-36
9154326-11	1997	The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with <protein-id="3458">IFN gamma/TNF alpha.	omega-N-Methylarginine	11-35	interleukin 1 beta	Homo sapiens	131-135
9154326-11	1997	The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with <protein-id="3458">IFN gamma/TNF alpha.	omega-N-Methylarginine	11-35	interleukin 1 beta	Homo sapiens	249-258
9154326-11	1997	The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with <protein-id="3458">IFN gamma/TNF alpha.	omega-N-Methylarginine	37-43	interleukin 1 beta	Homo sapiens	131-135
9154326-11	1997	The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with <protein-id="3458">IFN gamma/TNF alpha.	omega-N-Methylarginine	37-43	interleukin 1 beta	Homo sapiens	249-258
9154326-11	1997	The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with <protein-id="3458">IFN gamma/TNF alpha.	omega-N-Methylarginine	190-196	interleukin 1 beta	Homo sapiens	131-135
9154326-11	1997	The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with <protein-id="3458">IFN gamma/TNF alpha.	omega-N-Methylarginine	190-196	interleukin 1 beta	Homo sapiens	131-135
9154326-14	1997	Experiments with cysteine, which acts as a powerful reductant, suggest that the nitrosonium character of NO is involved in the NO-dependent pathway in IL-1 production.	Cysteine	17-25	interleukin 1 beta	Homo sapiens	151-155
9154326-14	1997	Experiments with cysteine, which acts as a powerful reductant, suggest that the nitrosonium character of NO is involved in the NO-dependent pathway in IL-1 production.	nitrosonium	80-91	interleukin 1 beta	Homo sapiens	151-155
9112403-4	1997	TSH-stimulated cultured human thyroid cells exposed for 72 h to IL-1beta (0.0002-20 microg/liter = 1-105 IU/liter) exhibited a dose-dependent and reversible inhibition of thyroglobulin and cAMP release and a dose-dependent stimulation of cGMP and IL-6 release.	Thyrotropin	0-3	interleukin 1 beta	Homo sapiens	64-72
9168406-4	1997	Isolated peripheral blood mononuclear cells from healthy women, but not CFS patients, exhibited significant menstrual cycle-related differences in IL-1 beta secretion that were related to estradiol and progesterone levels (R2 = 0.65, P &lt; 0.01).	Estradiol	188-197	interleukin 1 beta	Homo sapiens	147-156
9192731-6	1997	However, cleavage of the cross-link with 2-mercaptoethanol liberated a mature 17.5-kDa protein from preIL-1beta, suggesting that the pre-domains of IL-1beta might interact with the mature domain.	Mercaptoethanol	41-58	interleukin 1 beta	Homo sapiens	103-111
9112403-4	1997	TSH-stimulated cultured human thyroid cells exposed for 72 h to IL-1beta (0.0002-20 microg/liter = 1-105 IU/liter) exhibited a dose-dependent and reversible inhibition of thyroglobulin and cAMP release and a dose-dependent stimulation of cGMP and IL-6 release.	Cyclic AMP	189-193	interleukin 1 beta	Homo sapiens	64-72
9112403-4	1997	TSH-stimulated cultured human thyroid cells exposed for 72 h to IL-1beta (0.0002-20 microg/liter = 1-105 IU/liter) exhibited a dose-dependent and reversible inhibition of thyroglobulin and cAMP release and a dose-dependent stimulation of cGMP and IL-6 release.	Cyclic GMP	238-242	interleukin 1 beta	Homo sapiens	64-72
9112403-8	1997	These results indicate that all of the studied effects of IL-1beta on cultured human thyrocytes were exerted through activation of the IL-1 receptor with a signaling pathway involving activation of cGMP and inhibition of cAMP.	Cyclic GMP	198-202	interleukin 1 beta	Homo sapiens	58-66
9112403-8	1997	These results indicate that all of the studied effects of IL-1beta on cultured human thyrocytes were exerted through activation of the IL-1 receptor with a signaling pathway involving activation of cGMP and inhibition of cAMP.	Cyclic AMP	221-225	interleukin 1 beta	Homo sapiens	58-66
9168406-4	1997	Isolated peripheral blood mononuclear cells from healthy women, but not CFS patients, exhibited significant menstrual cycle-related differences in IL-1 beta secretion that were related to estradiol and progesterone levels (R2 = 0.65, P &lt; 0.01).	Progesterone	202-214	interleukin 1 beta	Homo sapiens	147-156
9168406-8	1997	These results suggest that an abnormality exists in IL-1 beta secretion in CFS patients that may be related to altered sensitivity to estradiol and progesterone.	Estradiol	134-143	interleukin 1 beta	Homo sapiens	52-61
9168406-8	1997	These results suggest that an abnormality exists in IL-1 beta secretion in CFS patients that may be related to altered sensitivity to estradiol and progesterone.	Progesterone	148-160	interleukin 1 beta	Homo sapiens	52-61
9366498-7	1997	The cytokine IL1-beta completely blocked the tamoxifen-dependent induction of SHBG gene expression in HepER3 cells, but only partly blocked the effect of moxestrol mediated by the ER.	Tamoxifen	45-54	interleukin 1 beta	Homo sapiens	13-21
9174899-0	1997	High glucose and hyperosmolarity increase secretion of interleukin-1 beta in cultured human aortic endothelial cells.	Glucose	5-12	interleukin 1 beta	Homo sapiens	55-73
9174899-5	1997	Under high concentration of glucose (16.6 mmol/L) and hyperosmolar condition (glucose 5.5 mmol/L + mannitol 11.1 mmol/L), the secretion of IL-1 beta was significantly increased (41.0 +/- 2.8 and 26.3 +/- 5.9% increase, respectively, compared with that of 5.5 mmol/L glucose).	Glucose	28-35	interleukin 1 beta	Homo sapiens	139-148
9174899-5	1997	Under high concentration of glucose (16.6 mmol/L) and hyperosmolar condition (glucose 5.5 mmol/L + mannitol 11.1 mmol/L), the secretion of IL-1 beta was significantly increased (41.0 +/- 2.8 and 26.3 +/- 5.9% increase, respectively, compared with that of 5.5 mmol/L glucose).	Glucose	78-85	interleukin 1 beta	Homo sapiens	139-148
9174899-5	1997	Under high concentration of glucose (16.6 mmol/L) and hyperosmolar condition (glucose 5.5 mmol/L + mannitol 11.1 mmol/L), the secretion of IL-1 beta was significantly increased (41.0 +/- 2.8 and 26.3 +/- 5.9% increase, respectively, compared with that of 5.5 mmol/L glucose).	Mannitol	99-107	interleukin 1 beta	Homo sapiens	139-148
9174899-5	1997	Under high concentration of glucose (16.6 mmol/L) and hyperosmolar condition (glucose 5.5 mmol/L + mannitol 11.1 mmol/L), the secretion of IL-1 beta was significantly increased (41.0 +/- 2.8 and 26.3 +/- 5.9% increase, respectively, compared with that of 5.5 mmol/L glucose).	Glucose	78-85	interleukin 1 beta	Homo sapiens	139-148
9174899-6	1997	In conclusion, high glucose and hyperosmolar condition increase the secretion of IL-1 beta in HAECs.	Glucose	20-27	interleukin 1 beta	Homo sapiens	81-90
9366498-7	1997	The cytokine IL1-beta completely blocked the tamoxifen-dependent induction of SHBG gene expression in HepER3 cells, but only partly blocked the effect of moxestrol mediated by the ER.	moxestrol	154-163	interleukin 1 beta	Homo sapiens	13-21
9176529-3	1997	METHODS: The effect of inhaled beclomethasone dipropionate (BDP) on asthmatic bronchial epithelial expression of IL-1 beta and IL-1ra was studied.	Beclomethasone	31-58	interleukin 1 beta	Homo sapiens	113-122
9176529-3	1997	METHODS: The effect of inhaled beclomethasone dipropionate (BDP) on asthmatic bronchial epithelial expression of IL-1 beta and IL-1ra was studied.	Beclomethasone	60-63	interleukin 1 beta	Homo sapiens	113-122
9176529-6	1997	RESULTS: There was a significant twofold decrease in the epithelial expression of IL-1 beta after treatment with BDP but no significant change was seen in IL-1ra (P = 0.175).	Beclomethasone	113-116	interleukin 1 beta	Homo sapiens	82-91
9176529-7	1997	CONCLUSION: The selective inhibition of IL-1 beta, without effect on IL-1ra, provides a novel mechanism for the anti-inflammatory action of glucocorticosteroids.	glucocorticosteroids	140-160	interleukin 1 beta	Homo sapiens	40-49
9131308-10	1997	The IL-1 activity of embryo culture-conditioned media, measured by [3H]thymidine incorporation in thymocytes was increased, compared with control media (442 +/- 51 counts/min vs. 337 +/- 13 counts/min, P &lt; 0.05), and the highest values corresponded to media containing those embryos that resulted in pregnancies (589 +/- 41 counts/min, P &lt; 0.01 vs. controls).	Tritium	68-70	interleukin 1 beta	Homo sapiens	4-8
9168911-5	1997	In endothelium-denuded segments of pulmonary artery, the inflammatory agennts tumor necrosis factor alpha, interleukin-1 beta, interferon gamma, and lipopolysaccharide stimulated the release of PGE2 and 8-iso PGF2 alpha, which were attenuated in both cases by the cyclo-oxygenase inhibitor indomethacin.	Dinoprostone	194-198	interleukin 1 beta	Homo sapiens	107-125
9168911-5	1997	In endothelium-denuded segments of pulmonary artery, the inflammatory agennts tumor necrosis factor alpha, interleukin-1 beta, interferon gamma, and lipopolysaccharide stimulated the release of PGE2 and 8-iso PGF2 alpha, which were attenuated in both cases by the cyclo-oxygenase inhibitor indomethacin.	8-iso pgf2	203-213	interleukin 1 beta	Homo sapiens	107-125
9168911-5	1997	In endothelium-denuded segments of pulmonary artery, the inflammatory agennts tumor necrosis factor alpha, interleukin-1 beta, interferon gamma, and lipopolysaccharide stimulated the release of PGE2 and 8-iso PGF2 alpha, which were attenuated in both cases by the cyclo-oxygenase inhibitor indomethacin.	Indomethacin	290-302	interleukin 1 beta	Homo sapiens	107-125
9099744-5	1997	Protein tyrosine phosphorylation following IL-1beta treatment may be dependent on redox changes since the IL-1beta receptor is not a protein-tyrosine kinase and oxidation has been shown to induce tyrosine phosphorylation.	Tyrosine	8-16	interleukin 1 beta	Homo sapiens	43-51
9099744-5	1997	Protein tyrosine phosphorylation following IL-1beta treatment may be dependent on redox changes since the IL-1beta receptor is not a protein-tyrosine kinase and oxidation has been shown to induce tyrosine phosphorylation.	Tyrosine	8-16	interleukin 1 beta	Homo sapiens	106-114
9099704-0	1997	Lectin-like characteristics of recombinant human interleukin-1beta recognizing glycans of the glycosylphosphatidylinositol anchor.	Polysaccharides	79-86	interleukin 1 beta	Homo sapiens	49-66
9099744-5	1997	Protein tyrosine phosphorylation following IL-1beta treatment may be dependent on redox changes since the IL-1beta receptor is not a protein-tyrosine kinase and oxidation has been shown to induce tyrosine phosphorylation.	Tyrosine	141-149	interleukin 1 beta	Homo sapiens	43-51
9099704-0	1997	Lectin-like characteristics of recombinant human interleukin-1beta recognizing glycans of the glycosylphosphatidylinositol anchor.	Glycosylphosphatidylinositols	94-122	interleukin 1 beta	Homo sapiens	49-66
9099744-6	1997	In this report we demonstrate that conditioning human glomerular mesangial cells with IL-1beta results in the tyrosine phosphorylation and activation of two members of the MAP kinase family, extracellular signal-regulated protein kinase 2 (ERK2) and p54 Jun-NH2-terminal kinase (JNK).	Tyrosine	110-118	interleukin 1 beta	Homo sapiens	86-94
9099704-1	1997	We found that 35S-labeled recombinant human interleukin-1beta (rhIL-1beta) binds phosphatidylinositol-specific phospholipase C-treated human placental alkaline phosphatase, phosphatidylinositol-specific phospholipase C-treated trypanosome surface variant glycoproteins, and urinary uromodulin immobilized on plates or immobilized on CNBr-activated Sepharose 4B.	Sulfur-35	14-17	interleukin 1 beta	Homo sapiens	44-61
9099744-7	1997	This effect of IL-1beta is abrogated by pretreating cells with the antioxidants N-acetyl-L-cysteine or dithiothreitol.	Acetylcysteine	80-99	interleukin 1 beta	Homo sapiens	15-23
9099704-1	1997	We found that 35S-labeled recombinant human interleukin-1beta (rhIL-1beta) binds phosphatidylinositol-specific phospholipase C-treated human placental alkaline phosphatase, phosphatidylinositol-specific phospholipase C-treated trypanosome surface variant glycoproteins, and urinary uromodulin immobilized on plates or immobilized on CNBr-activated Sepharose 4B.	Phosphatidylinositols	81-101	interleukin 1 beta	Homo sapiens	44-61
9099704-1	1997	We found that 35S-labeled recombinant human interleukin-1beta (rhIL-1beta) binds phosphatidylinositol-specific phospholipase C-treated human placental alkaline phosphatase, phosphatidylinositol-specific phospholipase C-treated trypanosome surface variant glycoproteins, and urinary uromodulin immobilized on plates or immobilized on CNBr-activated Sepharose 4B.	Sepharose	348-357	interleukin 1 beta	Homo sapiens	44-61
9099744-7	1997	This effect of IL-1beta is abrogated by pretreating cells with the antioxidants N-acetyl-L-cysteine or dithiothreitol.	Dithiothreitol	103-117	interleukin 1 beta	Homo sapiens	15-23
9099704-7	1997	Since the mannose 6-phosphate diester moiety exists only in the GPI glycans on plasma membranes, it was evident that interleukin-1beta can directly interact with the mannose 6-phosphate diester component of the intact glycan of GPI anchors on plasma membranes.	mannose-6-phosphate	10-29	interleukin 1 beta	Homo sapiens	117-134
9155955-12	1997	Danthrone at a concentration of 10 micrograms/ml and acetone (0.1%) similarly enhanced IL-1 secretion from human MO measured by both methods.	danthron	0-9	interleukin 1 beta	Homo sapiens	87-91
9099704-7	1997	Since the mannose 6-phosphate diester moiety exists only in the GPI glycans on plasma membranes, it was evident that interleukin-1beta can directly interact with the mannose 6-phosphate diester component of the intact glycan of GPI anchors on plasma membranes.	gpi glycans	64-75	interleukin 1 beta	Homo sapiens	117-134
9099704-7	1997	Since the mannose 6-phosphate diester moiety exists only in the GPI glycans on plasma membranes, it was evident that interleukin-1beta can directly interact with the mannose 6-phosphate diester component of the intact glycan of GPI anchors on plasma membranes.	mannose-6-phosphate	166-185	interleukin 1 beta	Homo sapiens	117-134
9099704-7	1997	Since the mannose 6-phosphate diester moiety exists only in the GPI glycans on plasma membranes, it was evident that interleukin-1beta can directly interact with the mannose 6-phosphate diester component of the intact glycan of GPI anchors on plasma membranes.	Polysaccharides	68-74	interleukin 1 beta	Homo sapiens	117-134
9099704-7	1997	Since the mannose 6-phosphate diester moiety exists only in the GPI glycans on plasma membranes, it was evident that interleukin-1beta can directly interact with the mannose 6-phosphate diester component of the intact glycan of GPI anchors on plasma membranes.	Glycosylphosphatidylinositols	64-67	interleukin 1 beta	Homo sapiens	117-134
9144567-2	1997	In cycloheximide or anisomycin treated cells, the accumulation of the IL-6 message and the activation of transcription factors required for IL-6 gene expression occurs at an extent similar to that obtained with IL-1beta.	Anisomycin	20-30	interleukin 1 beta	Homo sapiens	211-219
9103457-4	1997	Conversely, binding of IL-1beta to IL-1RII-bearing cells could be inhibited by DoB 0041 much less efficiently than by wild-type IL-1ra.	dob 0041	79-87	interleukin 1 beta	Homo sapiens	23-31
9155955-12	1997	Danthrone at a concentration of 10 micrograms/ml and acetone (0.1%) similarly enhanced IL-1 secretion from human MO measured by both methods.	Acetone	53-60	interleukin 1 beta	Homo sapiens	87-91
9120022-5	1997	TNFalpha- and IL-1beta-induced increases in eotaxin mRNA were diminished in a dose-dependent manner by the glucocorticoid dexamethasone and were augmented by the protein synthesis inhibitor cycloheximide.	Dexamethasone	122-135	interleukin 1 beta	Homo sapiens	14-22
9176074-4	1997	RESULTS: PTX inhibited the release of TNF-alpha by PBMCs from patients with inflammatory bowel disease and the secretion of TNF-alpha and IL-1 beta by organ cultures of inflamed mucosa from the same patients.	Pentoxifylline	9-12	interleukin 1 beta	Homo sapiens	138-147
9363644-0	1997	Interleukin-1 beta and interleukin-6 stimulate 2-methylaminoisobutyric acid uptake in HepG2 cells.	2,2-dimethyl-beta-alanine	47-75	interleukin 1 beta	Homo sapiens	0-18
9363644-5	1997	Interleukin-1 beta and interleukin-6 (1000 U/ml) stimulated methylaminoisobutyric acid uptake by 36 +/- 6 and 41 +/- 4%, respectively (per cent +/- SD, n &gt; or = 6).	2,2-dimethyl-beta-alanine	60-86	interleukin 1 beta	Homo sapiens	0-18
9363644-9	1997	These data demonstrate that, in our culture conditions, interleukin-1 beta and interleukin-6 indirectly exert a stimulatory effect on methylaminoisobutyric acid transport in HepG2 cells.	2,2-dimethyl-beta-alanine	134-160	interleukin 1 beta	Homo sapiens	56-74
9120022-5	1997	TNFalpha- and IL-1beta-induced increases in eotaxin mRNA were diminished in a dose-dependent manner by the glucocorticoid dexamethasone and were augmented by the protein synthesis inhibitor cycloheximide.	Cycloheximide	190-203	interleukin 1 beta	Homo sapiens	14-22
9077486-7	1997	That IgG-anti-MC stimulates an increase in IL-1beta and IFN-gamma production in controls suggests that IgG-anti-MC may play a role in melanocyte destruction mediated by monocytes.	Methylcholanthrene	14-16	interleukin 1 beta	Homo sapiens	43-51
9142649-11	1997	Thus, low levels of HNE can suppress mononuclear cell release of IL-1 beta, probably by interacting with the active site cysteine of ICE.	Cysteine	121-129	interleukin 1 beta	Homo sapiens	65-74
9120270-1	1997	The role of p38 mitogen-activated protein kinase (MAPK) in responses of human fibroblasts and vascular endothelial cells to IL-1 was investigated by use of a pyridinyl imidazole compound (SB 203580), which specifically inhibits the enzyme.	2-(1H-imidazol-2-yl)pyridine	158-177	interleukin 1 beta	Homo sapiens	124-128
9120270-2	1997	SB 203580 inhibited (50% inhibitory concentration approximately 0.5 microM) IL-1-induced phosphorylation of heat shock protein 27 (an indicator of p38 MAPK activity) in fibroblasts without affecting the other known IL-1-activated protein kinase pathways (p42/p44 MAPK, p54 MAPK/c-Jun N-terminal kinase and beta-casein kinase).	SB 203580	0-9	interleukin 1 beta	Homo sapiens	76-80
9120270-3	1997	SB 203580 significantly inhibited IL-1-stimulated IL-6, (30 to 50% at 1 microM) but not IL-8 production from human fibroblasts (gingival and dermal) and umbilical vein endothelial cells.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	34-38
9120270-5	1997	SB 203580 strongly inhibited IL-1-stimulated PG production by fibroblasts and human umbilical vein endothelial cells.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	29-33
9178369-2	1997	Exposure of PAEC to the combination of IFN-gamma, TNF-alpha, and IL-1 beta did not alter iNOS activity in cytosolic and membrane fractions but significantly (p &lt; 0.01) reduced eNOS activity in the membrane fraction, but not in the cytosolic fraction, after a 24-h exposure.	paec	12-16	interleukin 1 beta	Homo sapiens	65-74
9120270-5	1997	SB 203580 strongly inhibited IL-1-stimulated PG production by fibroblasts and human umbilical vein endothelial cells.	pg	45-47	interleukin 1 beta	Homo sapiens	29-33
9120270-7	1997	SB 203580 also inhibited the stimulation of collagenase-1 and stromelysin-1 production by IL-1 without affecting synthesis of the tissue inhibitor of metalloproteinases (TIMP)-1.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	90-94
9120270-8	1997	SB 203580 prevented the increase in collagenase-1 and stromelysin-1 mRNA stimulated by IL-1.	SB 203580	0-9	interleukin 1 beta	Homo sapiens	87-91
9120300-4	1997	In this study, we examined the effects of 5-lipoxygenase inhibitors (nordihydroguaiaretic acid and AA861) on IL-1 beta-induced VCAM-1 gene expression in HUVECs.	Masoprocol	69-94	interleukin 1 beta	Homo sapiens	109-118
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Homo sapiens	117-134
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Homo sapiens	136-144
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Homo sapiens	264-272
9176098-9	1997	C2-ceramide (20 microM) induced secretion of low amounts of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) from the monocytes.	N-acetylsphingosine	0-11	interleukin 1 beta	Homo sapiens	105-123
9176098-9	1997	C2-ceramide (20 microM) induced secretion of low amounts of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) from the monocytes.	N-acetylsphingosine	0-11	interleukin 1 beta	Homo sapiens	125-134
9176105-8	1997	AcLDL stimulated IL-8 secretion &gt; TNF-alpha &gt; IL-1 alpha &gt; IL-2 = IFN-gamma = IL-1 beta, and decreased GM-CSF secretion eightfold.	acldl	0-5	interleukin 1 beta	Homo sapiens	87-96
9065483-0	1997	p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta.	Dinoprostone	82-98	interleukin 1 beta	Homo sapiens	126-143
9065483-9	1997	The activation of p38 MAPK may provide a crucial signaling mechanism, which mediates the up-regulation of PG synthesis and the down-regulation of NO biosynthesis induced by IL-1beta.	Prostaglandins	106-108	interleukin 1 beta	Homo sapiens	173-181
9065483-1	1997	The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells.	Prostaglandins	173-187	interleukin 1 beta	Homo sapiens	26-43
9089293-6	1997	Cycloheximide strongly increased IL-1beta-induced TNF-alpha mRNA concentration indicating that de novo protein synthesis is not required for TNF-alpha gene expression.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	33-41
9065483-1	1997	The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells.	Prostaglandins	173-187	interleukin 1 beta	Homo sapiens	45-53
9065483-1	1997	The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells.	Prostaglandins	189-192	interleukin 1 beta	Homo sapiens	26-43
9065483-1	1997	The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells.	Prostaglandins	189-192	interleukin 1 beta	Homo sapiens	45-53
9065483-1	1997	The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells.	Nitric Oxide	198-210	interleukin 1 beta	Homo sapiens	26-43
9065483-1	1997	The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells.	Nitric Oxide	198-210	interleukin 1 beta	Homo sapiens	45-53
9065483-5	1997	Serum starvation and SC68376 selectively inhibited IL-1beta-induced activation of p38 MAPK.	2-methyl-4-phenyl-(4-pyridyl)oxazole	21-28	interleukin 1 beta	Homo sapiens	51-59
9087177-4	1997	In contrast, exposure of PBMC to hyperosmotic conditions (330-410 mOsM) by the addition of NaCl to tissue culture medium induced gene expression for IL-1 alpha, IL-1 beta, and IL-8.	PBMC	25-29	interleukin 1 beta	Homo sapiens	161-170
9087177-4	1997	In contrast, exposure of PBMC to hyperosmotic conditions (330-410 mOsM) by the addition of NaCl to tissue culture medium induced gene expression for IL-1 alpha, IL-1 beta, and IL-8.	Sodium Chloride	91-95	interleukin 1 beta	Homo sapiens	161-170
9093911-8	1997	However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	107-125
9093903-3	1997	On the reconstituted extracellular matrix (ECM) Matrigel freshly isolated HUVECs treated with interleukin-1 beta, lipopolysaccharide, and interferon-gamma, produced more NO, but less PGI2, than on gelatin substratum.	Epoprostenol	183-187	interleukin 1 beta	Homo sapiens	94-112
9100898-2	1997	These results imply that circulating IL-1 beta acts on its receptor on the endothelial cells of the brain vasculature to induce COX-2 mRNA, which is possibly responsible for the elevated level of PGE2 seen during fever.	Dinoprostone	196-200	interleukin 1 beta	Homo sapiens	37-46
9093911-8	1997	However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	127-136
9093911-8	1997	However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	268-277
9093911-8	1997	However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production.	Prostaglandins	37-39	interleukin 1 beta	Homo sapiens	107-125
9093911-8	1997	However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production.	Prostaglandins	37-39	interleukin 1 beta	Homo sapiens	127-136
9047011-7	1997	In contrast, IL-1 beta significantly stimulated PGF2 alpha production in a dose-dependent manner during the mid and late luteal phases (p &lt; 0.05).	Dinoprost	48-52	interleukin 1 beta	Homo sapiens	13-22
9047011-8	1997	Human CG alone had no effect on PGE2 or PGF2 alpha production by dispersed luteal cells in vitro but inhibited IL-1 beta-stimulated PGF2 alpha production.	Dinoprost	132-136	interleukin 1 beta	Homo sapiens	111-120
9047011-0	1997	Interleukin-1 beta modulates prostaglandin and progesterone production by primate luteal cells in vitro.	Prostaglandins	29-42	interleukin 1 beta	Homo sapiens	0-18
9047011-10	1997	Interestingly, IL-1 beta inhibited this hCG stimulation of progesterone production.	Progesterone	59-71	interleukin 1 beta	Homo sapiens	15-24
9047011-0	1997	Interleukin-1 beta modulates prostaglandin and progesterone production by primate luteal cells in vitro.	Progesterone	47-59	interleukin 1 beta	Homo sapiens	0-18
9047011-11	1997	In summary, these date suggest that IL-1 beta is a potentially important modulator of prostaglandin production by the primate corpus luteum.	Prostaglandins	86-99	interleukin 1 beta	Homo sapiens	36-45
9047011-3	1997	In the present study we examined the effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and interferon-gamma (IFN-gamma) on progesterone and prostaglandin (PGE2, PGF2 alpha) production by primate luteal cells in vitro.	Progesterone	157-169	interleukin 1 beta	Homo sapiens	48-66
9138684-9	1997	CdCl2 1 microM, ZnCl2 20-40 microM or HgCl2 2 microM pretreatment for 20 h induced MT-2 mRNA and total MT protein accumulation and had no effect on proliferation potential or metabolic activity, but significantly inhibited the ability of subsequent lipopolysaccharide treatment to induce the oxidative burst, increased adhesion to plastic, and MT-2 and interleukin-1 beta (IL-1 beta) mRNA accumulation.	Cadmium Chloride	0-5	interleukin 1 beta	Homo sapiens	353-371
9134225-13	1997	One of the following cytokines (epidermal growth factor, transforming growth factor alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interleukin-8) was required for 1,25(OH)2D3 to suppress clonal growth and induce cell differentiation.	25(oh)2d3	181-190	interleukin 1 beta	Homo sapiens	112-130
9138684-9	1997	CdCl2 1 microM, ZnCl2 20-40 microM or HgCl2 2 microM pretreatment for 20 h induced MT-2 mRNA and total MT protein accumulation and had no effect on proliferation potential or metabolic activity, but significantly inhibited the ability of subsequent lipopolysaccharide treatment to induce the oxidative burst, increased adhesion to plastic, and MT-2 and interleukin-1 beta (IL-1 beta) mRNA accumulation.	Cadmium Chloride	0-5	interleukin 1 beta	Homo sapiens	373-382
9138684-9	1997	CdCl2 1 microM, ZnCl2 20-40 microM or HgCl2 2 microM pretreatment for 20 h induced MT-2 mRNA and total MT protein accumulation and had no effect on proliferation potential or metabolic activity, but significantly inhibited the ability of subsequent lipopolysaccharide treatment to induce the oxidative burst, increased adhesion to plastic, and MT-2 and interleukin-1 beta (IL-1 beta) mRNA accumulation.	zinc chloride	16-21	interleukin 1 beta	Homo sapiens	353-371
9138698-13	1997	However, a mixture of cytokines (interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) each at 10 ng ml-1) induced COX-2 mRNA expression, which was maximal at 12 h and inhibited by dexamethasone (1 microM; added 30 min before the cytokines).	Dexamethasone	233-246	interleukin 1 beta	Homo sapiens	33-51
9138698-17	1997	Incubation of the cells with the cytokine mixture (IL-1 beta, TNF alpha, IFN gamma each at 10 ng ml-1 for 24 h) caused the accumulation of PGE2 and 6-keto-PGF1 alpha.	Dinoprostone	139-143	interleukin 1 beta	Homo sapiens	51-60
9138698-17	1997	Incubation of the cells with the cytokine mixture (IL-1 beta, TNF alpha, IFN gamma each at 10 ng ml-1 for 24 h) caused the accumulation of PGE2 and 6-keto-PGF1 alpha.	6-keto-pgf1	148-159	interleukin 1 beta	Homo sapiens	51-60
9138698-19	1997	In experiments where COX-2 metabolized endogenous stores of arachidonic acid, treatment of HASM cells with IL-1 beta in combination with TNF alpha caused a similar release of PGE2 to that when the three cytokines were given in combination.	Arachidonic Acid	60-76	interleukin 1 beta	Homo sapiens	107-116
9138698-19	1997	In experiments where COX-2 metabolized endogenous stores of arachidonic acid, treatment of HASM cells with IL-1 beta in combination with TNF alpha caused a similar release of PGE2 to that when the three cytokines were given in combination.	Dinoprostone	175-179	interleukin 1 beta	Homo sapiens	107-116
9138684-9	1997	CdCl2 1 microM, ZnCl2 20-40 microM or HgCl2 2 microM pretreatment for 20 h induced MT-2 mRNA and total MT protein accumulation and had no effect on proliferation potential or metabolic activity, but significantly inhibited the ability of subsequent lipopolysaccharide treatment to induce the oxidative burst, increased adhesion to plastic, and MT-2 and interleukin-1 beta (IL-1 beta) mRNA accumulation.	zinc chloride	16-21	interleukin 1 beta	Homo sapiens	373-382
9138684-9	1997	CdCl2 1 microM, ZnCl2 20-40 microM or HgCl2 2 microM pretreatment for 20 h induced MT-2 mRNA and total MT protein accumulation and had no effect on proliferation potential or metabolic activity, but significantly inhibited the ability of subsequent lipopolysaccharide treatment to induce the oxidative burst, increased adhesion to plastic, and MT-2 and interleukin-1 beta (IL-1 beta) mRNA accumulation.	Mercuric Chloride	38-43	interleukin 1 beta	Homo sapiens	353-371
9138684-9	1997	CdCl2 1 microM, ZnCl2 20-40 microM or HgCl2 2 microM pretreatment for 20 h induced MT-2 mRNA and total MT protein accumulation and had no effect on proliferation potential or metabolic activity, but significantly inhibited the ability of subsequent lipopolysaccharide treatment to induce the oxidative burst, increased adhesion to plastic, and MT-2 and interleukin-1 beta (IL-1 beta) mRNA accumulation.	Mercuric Chloride	38-43	interleukin 1 beta	Homo sapiens	373-382
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 beta	Homo sapiens	155-163
9196864-5	1997	RESULTS: The production of IL1-beta was significantly lower in the iloprost group than in the nifedipine group.	Iloprost	67-75	interleukin 1 beta	Homo sapiens	27-35
9196864-5	1997	RESULTS: The production of IL1-beta was significantly lower in the iloprost group than in the nifedipine group.	Nifedipine	94-104	interleukin 1 beta	Homo sapiens	27-35
9117018-1	1997	The purpose of this study was to determine the mechanism of enhanced prostaglandin synthesis in cultured human bronchial smooth-muscle cells challenged with interleukin-1 beta (IL-1 beta).	Prostaglandins	69-82	interleukin 1 beta	Homo sapiens	157-175
9117018-1	1997	The purpose of this study was to determine the mechanism of enhanced prostaglandin synthesis in cultured human bronchial smooth-muscle cells challenged with interleukin-1 beta (IL-1 beta).	Prostaglandins	69-82	interleukin 1 beta	Homo sapiens	177-186
9117018-3	1997	IL-1 beta enhanced PGE2 formation in a concentration- and time-dependent manner, reaching its peak at 6 to 8 h and fading at 18 to 24 h. Immunoblot analysis showed that the inducible cyclooxygenase enzyme (COX-2) was expressed only in IL-1 beta treated cells, whereas the constitutive isoform of cyclooxygenase (COX-1) remained unaltered.	Dinoprostone	19-23	interleukin 1 beta	Homo sapiens	0-9
9117018-3	1997	IL-1 beta enhanced PGE2 formation in a concentration- and time-dependent manner, reaching its peak at 6 to 8 h and fading at 18 to 24 h. Immunoblot analysis showed that the inducible cyclooxygenase enzyme (COX-2) was expressed only in IL-1 beta treated cells, whereas the constitutive isoform of cyclooxygenase (COX-1) remained unaltered.	Dinoprostone	19-23	interleukin 1 beta	Homo sapiens	235-244
9117018-6	1997	The close parallelism between the kinetics of COX-2 protein expression and PGE2 accumulation, as well as the constitutive nature of COX-1 isoform, indicate that IL-1 beta-driven PGE2 formation in human bronchial smooth-muscle cells is mediated by de novo expression of COX-2 enzyme.	Dinoprostone	75-79	interleukin 1 beta	Homo sapiens	161-170
9117018-6	1997	The close parallelism between the kinetics of COX-2 protein expression and PGE2 accumulation, as well as the constitutive nature of COX-1 isoform, indicate that IL-1 beta-driven PGE2 formation in human bronchial smooth-muscle cells is mediated by de novo expression of COX-2 enzyme.	Dinoprostone	178-182	interleukin 1 beta	Homo sapiens	161-170
9042815-12	1997	However, the group of patients with EH and increased IL-1beta levels had significantly higher mean concentrations of triglycerides (p &lt; 0.05) and significantly lower mean concentrations of high-density lipoprotein cholesterol (p &lt; 0.05) than those who had IL-1beta levels lower than the cutoff point.	Triglycerides	117-130	interleukin 1 beta	Homo sapiens	53-61
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 beta	Homo sapiens	252-260
9101429-7	1997	Stimulation of cells with interleukin-1 beta enhanced the synthesis of both fluorescent PI (approximately 88%) and PC (approximately 250%) compared to non-stimulated cells, but with less incorporation of 32Pi into fluorescent PI.	Phosphatidylcholines	115-117	interleukin 1 beta	Homo sapiens	26-44
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 beta	Homo sapiens	252-260
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 beta	Homo sapiens	155-163
9101429-7	1997	Stimulation of cells with interleukin-1 beta enhanced the synthesis of both fluorescent PI (approximately 88%) and PC (approximately 250%) compared to non-stimulated cells, but with less incorporation of 32Pi into fluorescent PI.	32pi	204-208	interleukin 1 beta	Homo sapiens	26-44
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 beta	Homo sapiens	252-260
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 beta	Homo sapiens	252-260
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 beta	Homo sapiens	83-91
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 beta	Homo sapiens	179-187
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	145-148	interleukin 1 beta	Homo sapiens	83-91
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	145-148	interleukin 1 beta	Homo sapiens	179-187
9085940-5	1997	Pretreatment of dermal papilla cells with Ro 31-7549, a selective protein kinase C inhibitor, dose dependently and completely reversed phorbol-induced IL-1beta protein production.	phorbol	135-142	interleukin 1 beta	Homo sapiens	151-159
9147372-0	1997	beta-Amyloid-induced IL-1 beta release from an activated human monocyte cell line is calcium- and G-protein-dependent.	Calcium	85-92	interleukin 1 beta	Homo sapiens	21-30
9058643-3	1997	Responsiveness of E11 to IL-1beta was analyzed by [3H] thymidine incorporation and Northern blotting.	Tritium	51-53	interleukin 1 beta	Homo sapiens	25-33
9058643-3	1997	Responsiveness of E11 to IL-1beta was analyzed by [3H] thymidine incorporation and Northern blotting.	Thymidine	55-64	interleukin 1 beta	Homo sapiens	25-33
9058654-4	1997	RESULTS: Compared with PBS, sera from controls and 24 patients with SLE suppressed IL-6 release from IL-1beta pretreated cells.	pbs	23-26	interleukin 1 beta	Homo sapiens	101-109
9106231-2	1997	Cultures of human fetal astrocytes and microglia produce inducible nitric oxide synthase and nitric oxide in response to Interferon gamma and Interleukin 1 beta.	Nitric Oxide	67-79	interleukin 1 beta	Homo sapiens	142-160
9089670-0	1997	Interleukin-1 beta and tumor necrosis factor-alpha inhibit the release of [3H]-noradrenaline from isolated human atrial appendages.	3h]-noradrenaline	75-92	interleukin 1 beta	Homo sapiens	0-50
9147372-11	1997	IL- 1 beta release from activated THP-1 monocytes incubated with TMB-8 and nickel chloride without A beta remained at baseline values.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	65-70	interleukin 1 beta	Homo sapiens	0-10
9147372-11	1997	IL- 1 beta release from activated THP-1 monocytes incubated with TMB-8 and nickel chloride without A beta remained at baseline values.	nickel chloride	75-90	interleukin 1 beta	Homo sapiens	0-10
9147372-13	1997	These data suggest that A beta-induced IL-1 beta release from these cells is calcium-dependent and requires the activation of specific G-proteins.	Calcium	77-84	interleukin 1 beta	Homo sapiens	39-48
9089670-7	1997	The results showed that in human atrium, hIL-1 beta (3 ng/ml) and hTNF-alpha (0.5 ng/ml) significantly inhibited the S-I release of [3H]-NA.	Tritium	133-135	interleukin 1 beta	Homo sapiens	41-51
9089796-3	1997	A 3 hour incubation of HPASMC with LPS, IL-1 beta, or TNF alpha followed by a 10 min exposure to 2 U/ml thrombin was sufficient to generate a greater amount of PGI2 than observed in control cells.	Epoprostenol	160-164	interleukin 1 beta	Homo sapiens	40-49
9089670-8	1997	The inhibitory effect of hIL-1 beta was blocked by human recombinant IL-1 receptor antagonist (50 ng/ml), and by the cyclooxygenase inhibitor, diclofenac (1 mumol/l), suggesting that hIL-1 beta inhibited NA release through the formation of prostaglandins.	Diclofenac	143-153	interleukin 1 beta	Homo sapiens	25-35
9089670-8	1997	The inhibitory effect of hIL-1 beta was blocked by human recombinant IL-1 receptor antagonist (50 ng/ml), and by the cyclooxygenase inhibitor, diclofenac (1 mumol/l), suggesting that hIL-1 beta inhibited NA release through the formation of prostaglandins.	Diclofenac	143-153	interleukin 1 beta	Homo sapiens	183-193
9089670-8	1997	The inhibitory effect of hIL-1 beta was blocked by human recombinant IL-1 receptor antagonist (50 ng/ml), and by the cyclooxygenase inhibitor, diclofenac (1 mumol/l), suggesting that hIL-1 beta inhibited NA release through the formation of prostaglandins.	Prostaglandins	240-254	interleukin 1 beta	Homo sapiens	25-35
9089796-4	1997	The increase in PGI2 production peaked after 8 h in the IL-1 beta- and TNF alpha-treated HPASMC, and continued to increase for 24 h in the LPS-treated HPASMC.	Epoprostenol	16-20	interleukin 1 beta	Homo sapiens	56-65
9089796-6	1997	In contrast, the exposure of LPS- or IL-1 beta-treated HPASMC to buffer seemed to increase the release of PGI2 for up to 30 min of incubation.	Epoprostenol	106-110	interleukin 1 beta	Homo sapiens	37-46
9089796-8	1997	After incubation with various concentrations of LPS or cytokines, the production of PGI2 by thrombin-stimulated HPASMC showed significant, dose-dependent increases beginning at 0.1 microgram/ml of LPS, 20 U/ml of IL-1 beta, and 50 U/ml of TNF alpha.	Epoprostenol	84-88	interleukin 1 beta	Homo sapiens	213-222
9127437-2	1997	The beta-agonists, procaterol, clenbuterol, fenoterol and terbutaline, inhibited TNF-alpha and IL-1 beta production in a concentration-dependent manner, whereas they had no effect on IL-8 production.	Procaterol	19-29	interleukin 1 beta	Homo sapiens	95-104
9089796-9	1997	We conclude that LPS, IL-1 beta, and TNF alpha enhanced both the basal and thrombin-stimulated production of PGI2 by HPASMC.	Epoprostenol	109-113	interleukin 1 beta	Homo sapiens	22-31
9127437-2	1997	The beta-agonists, procaterol, clenbuterol, fenoterol and terbutaline, inhibited TNF-alpha and IL-1 beta production in a concentration-dependent manner, whereas they had no effect on IL-8 production.	Clenbuterol	31-42	interleukin 1 beta	Homo sapiens	95-104
9127437-2	1997	The beta-agonists, procaterol, clenbuterol, fenoterol and terbutaline, inhibited TNF-alpha and IL-1 beta production in a concentration-dependent manner, whereas they had no effect on IL-8 production.	Fenoterol	44-53	interleukin 1 beta	Homo sapiens	95-104
9034269-7	1997	INTERVENTIONS: Endothelial cell monolayers were pretreated with increasing concentrations of amrinone or dopamine, or left untreated as controls, followed by exposure to recombinant human interleukin (IL)-1beta for 6 hrs.	Amrinone	93-101	interleukin 1 beta	Homo sapiens	188-210
9127437-2	1997	The beta-agonists, procaterol, clenbuterol, fenoterol and terbutaline, inhibited TNF-alpha and IL-1 beta production in a concentration-dependent manner, whereas they had no effect on IL-8 production.	Terbutaline	58-69	interleukin 1 beta	Homo sapiens	95-104
9127437-4	1997	Dibutyryl cyclic AMP (dbcAMP) also inhibited the production of TNF-alpha and IL-1 beta, but not IL-8.	Bucladesine	0-20	interleukin 1 beta	Homo sapiens	77-86
9127437-4	1997	Dibutyryl cyclic AMP (dbcAMP) also inhibited the production of TNF-alpha and IL-1 beta, but not IL-8.	Bucladesine	22-28	interleukin 1 beta	Homo sapiens	77-86
9127437-7	1997	The inhibition of TNF-alpha and IL-1 beta production by procaterol was additively potentiated with theophylline.	Procaterol	56-66	interleukin 1 beta	Homo sapiens	32-41
9127437-8	1997	dl-Propranolol, a beta-adrenoceptor antagonist, abrogated the inhibition of TNF-alpha and IL-1 beta production by procaterol.	Propranolol	0-14	interleukin 1 beta	Homo sapiens	90-99
9127437-9	1997	These results indicate that beta-agonists inhibit the production of proinflammatory cytokines, such as TNF-alpha and IL-1 beta, by elevating intracellular cAMP levels.	Cyclic AMP	155-159	interleukin 1 beta	Homo sapiens	117-126
9059850-6	1997	Only interleukin-1 beta treatment resulted in significant nitrite production, immunohistochemical staining for inducible nitric oxide synthase and detection of inducible NO synthase messenger RNA by reverse transcriptase-polymerase chain reaction (RT-PCR).	Nitrites	58-65	interleukin 1 beta	Homo sapiens	5-23
9059850-7	1997	However, tumor necrosis factor alpha, interleukin-1 beta, interleukin-6, and NMA each completely blocked the positive chronotropic effects of the beta-adrenoceptor agonist, isoproterenol (P &lt; 0.01; n = 12 for each).	Isoproterenol	173-186	interleukin 1 beta	Homo sapiens	38-56
9124475-5	1997	In seven of nine AV3V neurons that were electrophysiologically identified to send their axons to the mPOA or the PVN, the recombinant human IL-1beta-induced excitation and inhibition were attenuated by a local application of sodium salicylate through multibarreled micropipettes.	Sodium Salicylate	225-242	interleukin 1 beta	Homo sapiens	140-148
9124475-6	1997	These results suggest that the AV3V neurons alter their activity in response to the blood-borne IL-1beta, at least in part, through a local synthesis of prostanoids and then send the information to the mPOA and PVN.	Prostaglandins	153-164	interleukin 1 beta	Homo sapiens	96-104
9053458-8	1997	In vitro and in vivo activation of the macrophage and microglial cell P2Z/P2X7 receptor by exogenous ATP causes a large and rapid release of mature IL-1 beta.	Adenosine Triphosphate	101-104	interleukin 1 beta	Homo sapiens	148-157
9053458-10	1997	Our data suggest that LPS-dependent IL-1 beta release involves activation of this purinergic receptor as it is inhibited by the selective P2Z/P2X7 blocker oxidized ATP and modulated by ATP-hydrolyzing enzymes such as apyrase or hexokinase.	Adenosine Triphosphate	164-167	interleukin 1 beta	Homo sapiens	36-45
9053458-10	1997	Our data suggest that LPS-dependent IL-1 beta release involves activation of this purinergic receptor as it is inhibited by the selective P2Z/P2X7 blocker oxidized ATP and modulated by ATP-hydrolyzing enzymes such as apyrase or hexokinase.	Adenosine Triphosphate	185-188	interleukin 1 beta	Homo sapiens	36-45
9053458-13	1997	It is suggested that bacterial endotoxin activates an autocrine/paracrine loop that drives ATP-dependent IL-1 beta secretion.	Adenosine Triphosphate	91-94	interleukin 1 beta	Homo sapiens	105-114
9041915-11	1997	The responses of IL-6 and IL-1 beta in group 1 were striking compared with those in group 2, and they were accompanied by an elevation of the endotoxin concentration and a subsequent elevation of the concentrations of hepatocyte growth factor, hyaluronic acid, lactate, and other factors that reflected graft viability.	Lactic Acid	261-268	interleukin 1 beta	Homo sapiens	26-35
9051240-1	1997	We studied the effects of escalating doses of recombinant human IL-1 beta in patients receiving high-dose chemotherapy and ABMT for metastatic breast cancer or malignant melanoma.	abmt	123-127	interleukin 1 beta	Homo sapiens	64-73
9052735-0	1997	A negative regulatory region containing a glucocorticosteroid response element (nGRE) in the human interleukin-1beta gene.	glucocorticosteroid	42-61	interleukin 1 beta	Homo sapiens	99-116
9067703-1	1997	Among epidermal cytokines, IL-1 and TNF alpha are involved in inflammatory skin reactions and suspected of modulation by immunosuppressive treatment (e.g., cyclosporin A, CsA) or UVB-irradiation, 2 mediators probably being involved in epithelial carcinogenesis.	Cyclosporine	156-169	interleukin 1 beta	Homo sapiens	27-31
9067703-1	1997	Among epidermal cytokines, IL-1 and TNF alpha are involved in inflammatory skin reactions and suspected of modulation by immunosuppressive treatment (e.g., cyclosporin A, CsA) or UVB-irradiation, 2 mediators probably being involved in epithelial carcinogenesis.	Cyclosporine	171-174	interleukin 1 beta	Homo sapiens	27-31
9067703-2	1997	We evaluated the effects of 8 micrograms/ml CsA and 100 J/m2 UVB-irradiation on the production and secretion of IL-1 and TNF alpha on normal human epidermal keratinocytes (NHK) and epidermal keratinocyte cell lines either spontaneously transformed (HaCaT) or transformed by human papillomavirus (HPV) type 16 or 18 (EK 16 and EK18), by using ELISA test.	Cyclosporine	44-47	interleukin 1 beta	Homo sapiens	112-116
9067703-6	1997	CsA modified significantly the production and secretion of IL1 in most cells whereas slight changes were observed with TNF alpha secretion.	Cyclosporine	0-3	interleukin 1 beta	Homo sapiens	59-62
9067703-9	1997	Taken together, these results show that, in immortalized keratinocytes, the IL-1 and TNF alpha expression was differently affected by treatments with CsA and/or UVB-irradiation as compared to NHK.	Cyclosporine	150-153	interleukin 1 beta	Homo sapiens	76-80
9023325-1	1997	These studies examined the signal transduction mechanisms by which prostaglandin (PG) E2 production can occur in human amnionic WISH cells in response to the stimuli okadaic acid, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, phorbol-12-myristate-13-acetate (PMA) or combinations of PMA with IL-1beta or TNF-alpha.	Dinoprostone	67-88	interleukin 1 beta	Homo sapiens	305-313
9040477-1	1997	PURPOSE: To examine the modulation of interleukin-1 beta (IL-1 beta)- and tumor necrosis factor-alpha (TNF-alpha)-stimulated monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8) secretion and transcription in human retinal pigment epithelial (HRPE) cells by dexamethasone (DEX) and cyclosporin A (CSA).	Dexamethasone	269-282	interleukin 1 beta	Homo sapiens	38-56
9003059-5	1997	Furthermore, PGE2 potentiated IL-1 beta-induced IL-6 mRNA synthesis.	Dinoprostone	13-17	interleukin 1 beta	Homo sapiens	30-39
9040477-1	1997	PURPOSE: To examine the modulation of interleukin-1 beta (IL-1 beta)- and tumor necrosis factor-alpha (TNF-alpha)-stimulated monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8) secretion and transcription in human retinal pigment epithelial (HRPE) cells by dexamethasone (DEX) and cyclosporin A (CSA).	Dexamethasone	284-287	interleukin 1 beta	Homo sapiens	38-56
9040477-5	1997	RESULTS: Although DEX (10(-8) to 10(-6) M) inhibited IL-1 beta-stimulated MCP-1 and IL-8 production, it did not inhibit TNF-alpha-stimulated chemokine secretion.	Dexamethasone	18-21	interleukin 1 beta	Homo sapiens	53-62
9040477-9	1997	CONCLUSIONS: Although DEX and CSA inhibit HRPE MCP-1 and IL-8 secretion, this is dependent on whether the inducing inflammatory mediator is IL-1 beta or TNF-alpha.	Dexamethasone	22-25	interleukin 1 beta	Homo sapiens	140-149
9040477-10	1997	IL-1 beta-induced chemokine secretion is sensitive to DEX, whereas MCP-1 and IL-8 induced by TNF-alpha are inhibited by CSA.	Dexamethasone	54-57	interleukin 1 beta	Homo sapiens	0-9
9162741-2	1997	In a previous study, we investigated the effect of various cytokines on triacylglycerol and apoB secretion by CaCo-2 cells and observed that TNF-alpha, IL-1 beta, and particularly IL-6, decreased apolipoprotein (apo) B and triacylglycerol secretion.	Triglycerides	72-87	interleukin 1 beta	Homo sapiens	152-161
9162741-2	1997	In a previous study, we investigated the effect of various cytokines on triacylglycerol and apoB secretion by CaCo-2 cells and observed that TNF-alpha, IL-1 beta, and particularly IL-6, decreased apolipoprotein (apo) B and triacylglycerol secretion.	Triglycerides	223-238	interleukin 1 beta	Homo sapiens	152-161
9023325-1	1997	These studies examined the signal transduction mechanisms by which prostaglandin (PG) E2 production can occur in human amnionic WISH cells in response to the stimuli okadaic acid, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, phorbol-12-myristate-13-acetate (PMA) or combinations of PMA with IL-1beta or TNF-alpha.	Dinoprostone	67-88	interleukin 1 beta	Homo sapiens	180-202
9023325-4	1997	PMA or IL-1beta induced PGE2 production 2 to 4 hr after treatment, whereas the combination of these agents produced the most rapid induction 2 hr after treatment.	Dinoprostone	24-28	interleukin 1 beta	Homo sapiens	7-15
9023325-9	1997	The ability of IL-1ra to reduce PGE2 production caused by all stimuli used suggests an autocrine role for IL-1 in PGHS-2 induction in these cells.	Dinoprostone	32-36	interleukin 1 beta	Homo sapiens	15-19
9561147-0	1997	Differential effect of corticotropin releasing factor on interleukin-1 alpha and interleukin-1 beta-induced prostaglandin synthesis in endothelial cells and fibroblasts.	Prostaglandins	108-121	interleukin 1 beta	Homo sapiens	81-99
9051715-0	1997	Cell-cell interaction between platelets and IL-1 beta-stimulated vascular smooth muscle cells in synthesis of thromboxane A2.	Thromboxane A2	110-124	interleukin 1 beta	Homo sapiens	44-53
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	6-keto-pgf1	114-125	interleukin 1 beta	Homo sapiens	24-42
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	6-keto-pgf1	114-125	interleukin 1 beta	Homo sapiens	44-53
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Dinoprostone	133-137	interleukin 1 beta	Homo sapiens	24-42
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Dinoprostone	133-137	interleukin 1 beta	Homo sapiens	44-53
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Dinoprost	139-143	interleukin 1 beta	Homo sapiens	24-42
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Dinoprost	139-143	interleukin 1 beta	Homo sapiens	44-53
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	5-hydroxy-6,8,11,14-eicosatetraenoic acid	166-174	interleukin 1 beta	Homo sapiens	24-42
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	5-hydroxy-6,8,11,14-eicosatetraenoic acid	166-174	interleukin 1 beta	Homo sapiens	44-53
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Phosphatidylcholines	218-237	interleukin 1 beta	Homo sapiens	24-42
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Phosphatidylcholines	218-237	interleukin 1 beta	Homo sapiens	44-53
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Phosphatidylcholines	239-241	interleukin 1 beta	Homo sapiens	24-42
9051715-2	1997	Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites (e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine (PC) in SMC.	Phosphatidylcholines	239-241	interleukin 1 beta	Homo sapiens	44-53
9051715-4	1997	Furthermore, TXB2 was produced in large quantities during co-incubation of IL-1 beta-stimulated SMC with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids (PGE2, PGF2 alpha and PGD2) compared with control (P &lt; 0.01).	6-keto-pgf1	174-185	interleukin 1 beta	Homo sapiens	75-84
9051715-4	1997	Furthermore, TXB2 was produced in large quantities during co-incubation of IL-1 beta-stimulated SMC with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids (PGE2, PGF2 alpha and PGD2) compared with control (P &lt; 0.01).	Eicosanoids	196-207	interleukin 1 beta	Homo sapiens	75-84
9051715-4	1997	Furthermore, TXB2 was produced in large quantities during co-incubation of IL-1 beta-stimulated SMC with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids (PGE2, PGF2 alpha and PGD2) compared with control (P &lt; 0.01).	Dinoprostone	209-213	interleukin 1 beta	Homo sapiens	75-84
9051715-4	1997	Furthermore, TXB2 was produced in large quantities during co-incubation of IL-1 beta-stimulated SMC with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids (PGE2, PGF2 alpha and PGD2) compared with control (P &lt; 0.01).	Dinoprost	215-219	interleukin 1 beta	Homo sapiens	75-84
9051715-5	1997	Pretreatment of SMC with cycloheximide and actinomycin not only inhibited IL-1 beta-induced eicosanoid synthesis and phospholipid breakdown but also diminished TXB2 production when co-incubated with platelets.	Cycloheximide	25-38	interleukin 1 beta	Homo sapiens	74-83
9051715-5	1997	Pretreatment of SMC with cycloheximide and actinomycin not only inhibited IL-1 beta-induced eicosanoid synthesis and phospholipid breakdown but also diminished TXB2 production when co-incubated with platelets.	Dactinomycin	43-54	interleukin 1 beta	Homo sapiens	74-83
9051715-5	1997	Pretreatment of SMC with cycloheximide and actinomycin not only inhibited IL-1 beta-induced eicosanoid synthesis and phospholipid breakdown but also diminished TXB2 production when co-incubated with platelets.	Eicosanoids	92-102	interleukin 1 beta	Homo sapiens	74-83
9051715-5	1997	Pretreatment of SMC with cycloheximide and actinomycin not only inhibited IL-1 beta-induced eicosanoid synthesis and phospholipid breakdown but also diminished TXB2 production when co-incubated with platelets.	Phospholipids	117-129	interleukin 1 beta	Homo sapiens	74-83
9089489-7	1997	Most of the stimulation was blocked by Cx, indicating that the regulation of decorin gene expression by IL-1 beta may be via an indirect pathway, requiring new protein synthesis which regulates the promoter.	Cycloheximide	39-41	interleukin 1 beta	Homo sapiens	104-113
9561158-2	1997	In the previous study, we demonstrated that osteoclast formation induced by IL-1 beta was mediated by PGE2 produced by induced prostaglandin endoperoxide H synthase-2 (PGHS-2) in osteoclastic cells.	Dinoprostone	102-106	interleukin 1 beta	Homo sapiens	76-85
9048452-7	1997	This study found greater detection frequencies of P. nigrescens, P. micros, F. nucleatum ss vincentii, and F. nucleatum ss nucleatum, as well as significant elevations in GCF levels of PGE2, IL-1 beta, and PDGF in mouths with failing implant sites as compared to mouths with healthy control implants.	Dinoprostone	185-189	interleukin 1 beta	Homo sapiens	191-200
9382161-0	1997	Chronic effects of long-term acetate-free biofiltration on the production of interleukin-1beta and interleukin-1 receptor antagonist by peripheral blood mononuclear cells.	Acetates	29-36	interleukin 1 beta	Homo sapiens	77-94
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	Nitric Oxide	142-154	interleukin 1 beta	Homo sapiens	29-47
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	Nitric Oxide	142-154	interleukin 1 beta	Homo sapiens	49-58
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	[3h]arginine	230-242	interleukin 1 beta	Homo sapiens	29-47
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	[3h]arginine	230-242	interleukin 1 beta	Homo sapiens	49-58
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	[3h]citrulline	246-260	interleukin 1 beta	Homo sapiens	29-47
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	[3h]citrulline	246-260	interleukin 1 beta	Homo sapiens	49-58
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	Nitrogen Dioxide	265-268	interleukin 1 beta	Homo sapiens	29-47
8977400-1	1997	In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium.	Nitrogen Dioxide	265-268	interleukin 1 beta	Homo sapiens	49-58
8977400-2	1997	Although FSH alone failed to stimulate NOS activity, concomitant treatment with the gonadotropin (200 ng/ ml) or the cell-permeant cAMP analog (Bu)2cAMP (0.5 mM) markedly enhanced IL-1 beta-induced NO generation in cultured granulosa cells.	Cyclic AMP	131-135	interleukin 1 beta	Homo sapiens	180-189
8977400-2	1997	Although FSH alone failed to stimulate NOS activity, concomitant treatment with the gonadotropin (200 ng/ ml) or the cell-permeant cAMP analog (Bu)2cAMP (0.5 mM) markedly enhanced IL-1 beta-induced NO generation in cultured granulosa cells.	(bu)2camp	143-152	interleukin 1 beta	Homo sapiens	180-189
8977400-3	1997	The effect of IL-1 beta on citrulline biosynthesis and NO2- accumulation was abrogated by the NOS inhibitor NG-methyl-L-arginine or the IL-1-receptor antagonist protein.	Citrulline	27-37	interleukin 1 beta	Homo sapiens	14-23
8977400-3	1997	The effect of IL-1 beta on citrulline biosynthesis and NO2- accumulation was abrogated by the NOS inhibitor NG-methyl-L-arginine or the IL-1-receptor antagonist protein.	Nitrogen Dioxide	55-58	interleukin 1 beta	Homo sapiens	14-23
8977400-3	1997	The effect of IL-1 beta on citrulline biosynthesis and NO2- accumulation was abrogated by the NOS inhibitor NG-methyl-L-arginine or the IL-1-receptor antagonist protein.	ng-methyl-l-arginine	108-128	interleukin 1 beta	Homo sapiens	14-23
8977400-5	1997	As demonstrated by reverse transcriptase-PCR analysis, IL-1 beta-stimulated NO generation was accompanied by a time-dependent increase in messenger RNA levels for iNOS and GTP-cyclohydrolase (GTPCH), the rate-limiting step for de novo tetrahydrobiopterin (BH4) biosynthesis.	sapropterin	235-254	interleukin 1 beta	Homo sapiens	55-64
8977400-5	1997	As demonstrated by reverse transcriptase-PCR analysis, IL-1 beta-stimulated NO generation was accompanied by a time-dependent increase in messenger RNA levels for iNOS and GTP-cyclohydrolase (GTPCH), the rate-limiting step for de novo tetrahydrobiopterin (BH4) biosynthesis.	sapropterin	256-259	interleukin 1 beta	Homo sapiens	55-64
8977400-7	1997	Treatment with the GTPCH inhibitor 2,4-diamino-6-hydroxypyrimidine prevented IL-1 beta-induced NOS activity in untreated or FSH-stimulated cells, and this inhibition was completely reversed by sepiapterin, a substrate for BH4 biosynthesis, via an alternative pterin salvage pathway present in many cell types.	2,4-diaminohypoxanthine	35-66	interleukin 1 beta	Homo sapiens	77-86
8977400-7	1997	Treatment with the GTPCH inhibitor 2,4-diamino-6-hydroxypyrimidine prevented IL-1 beta-induced NOS activity in untreated or FSH-stimulated cells, and this inhibition was completely reversed by sepiapterin, a substrate for BH4 biosynthesis, via an alternative pterin salvage pathway present in many cell types.	sepiapterin	193-204	interleukin 1 beta	Homo sapiens	77-86
8977400-7	1997	Treatment with the GTPCH inhibitor 2,4-diamino-6-hydroxypyrimidine prevented IL-1 beta-induced NOS activity in untreated or FSH-stimulated cells, and this inhibition was completely reversed by sepiapterin, a substrate for BH4 biosynthesis, via an alternative pterin salvage pathway present in many cell types.	sapropterin	222-225	interleukin 1 beta	Homo sapiens	77-86
8977400-7	1997	Treatment with the GTPCH inhibitor 2,4-diamino-6-hydroxypyrimidine prevented IL-1 beta-induced NOS activity in untreated or FSH-stimulated cells, and this inhibition was completely reversed by sepiapterin, a substrate for BH4 biosynthesis, via an alternative pterin salvage pathway present in many cell types.	Pterins	198-204	interleukin 1 beta	Homo sapiens	77-86
8977400-8	1997	As BH4 is an essential cofactor for NOS catalytic activity, these observations strongly suggest that FSH-induced biosynthesis of endogenous BH4 is essential for full iNOS biosynthetic capacity in IL-1 beta-stimulated granulosa cells.	sapropterin	3-6	interleukin 1 beta	Homo sapiens	196-205
8977400-8	1997	As BH4 is an essential cofactor for NOS catalytic activity, these observations strongly suggest that FSH-induced biosynthesis of endogenous BH4 is essential for full iNOS biosynthetic capacity in IL-1 beta-stimulated granulosa cells.	sapropterin	140-143	interleukin 1 beta	Homo sapiens	196-205
9309381-9	1997	Therefore, SK&amp;F 86002 may inhibit IL6 production in osteoblastic cells via a more direct mechanism, possibly involving inhibition of the p38 MAP kinase, the mechanism proposed for its inhibition of IL 1 beta and TNF alpha release.	amicloral	11-17	interleukin 1 beta	Homo sapiens	202-211
9155574-9	1997	However, IL 1 beta dose dependently inhibited db-cAMP and histamine stimulated pepsinogen secretion.	Bucladesine	46-53	interleukin 1 beta	Homo sapiens	9-18
9155574-9	1997	However, IL 1 beta dose dependently inhibited db-cAMP and histamine stimulated pepsinogen secretion.	Histamine	58-67	interleukin 1 beta	Homo sapiens	9-18
8989257-13	1997	Interleukin-1 beta counteracted E2 + MPA-mediated inhibition of secreted MMP-3 levels, implying that leukocyte/trophoblast-derived cytokines can modulate steroid-regulated MMP-3 expression by stromal/decidual cells during menstruation and pregnancy.	Steroids	154-161	interleukin 1 beta	Homo sapiens	0-18
9011565-3	1997	The impaired relaxation responses to isoproterenol and PGE2 were ablated in sensitized TSM that were pretreated with either the IL-1 recombinant human receptor antagonist or an IL-1beta-neutralizing antibody.	Isoproterenol	37-50	interleukin 1 beta	Homo sapiens	177-185
9315512-3	1997	Interleukin-1beta (IL-1) enhanced PGE2 production in cultured normal fibroblasts and CRL-1475 cells.	Dinoprostone	34-38	interleukin 1 beta	Homo sapiens	0-17
8977194-7	1997	In HT-29 cells stimulated with IL-1beta, IkappaB alpha was phosphorylated and when cycloheximide blocked new protein synthesis, IkappaB alpha was partially degraded.	Cycloheximide	83-96	interleukin 1 beta	Homo sapiens	31-39
8977210-1	1997	Synthesis of TNF-alpha and IL-1beta, by monocytes/macrophages can be partially regulated by the eicosanoid, PGE2.	Eicosanoids	96-106	interleukin 1 beta	Homo sapiens	27-35
8977210-1	1997	Synthesis of TNF-alpha and IL-1beta, by monocytes/macrophages can be partially regulated by the eicosanoid, PGE2.	Dinoprostone	108-112	interleukin 1 beta	Homo sapiens	27-35
8977210-4	1997	Inhibition of thromboxane synthase by carboxyheptyl imidazole (CI) resulted in inhibition of TNF-alpha (61 +/- 4.3%; n = 8; p &lt; 0.001) and IL-1beta (54 +/- 4.2%; n = 8; p &lt; 0.001) synthesis by serum-treated zymosan-stimulated nonadherent human monocytes.	1-carboxyheptylimidazole	38-61	interleukin 1 beta	Homo sapiens	142-150
8977210-4	1997	Inhibition of thromboxane synthase by carboxyheptyl imidazole (CI) resulted in inhibition of TNF-alpha (61 +/- 4.3%; n = 8; p &lt; 0.001) and IL-1beta (54 +/- 4.2%; n = 8; p &lt; 0.001) synthesis by serum-treated zymosan-stimulated nonadherent human monocytes.	1-carboxyheptylimidazole	63-65	interleukin 1 beta	Homo sapiens	142-150
8977210-6	1997	Furthermore, the addition of a TXA2 agonist, carbocyclic TXA2, to CI-treated monocytes dose-dependently restored the levels of TNF-alpha and IL-1beta synthesis to those found with serum-treated zymosan stimulation alone.	1-carboxyheptylimidazole	66-68	interleukin 1 beta	Homo sapiens	141-149
8977210-6	1997	Furthermore, the addition of a TXA2 agonist, carbocyclic TXA2, to CI-treated monocytes dose-dependently restored the levels of TNF-alpha and IL-1beta synthesis to those found with serum-treated zymosan stimulation alone.	Zymosan	194-201	interleukin 1 beta	Homo sapiens	141-149
9066525-7	1997	Interfacial membrane mononuclear cells also produced high levels of interleukin-1 alpha, interleukin-1 beta, and prostaglandin E2 and expressed bone resorptive activities following stimulation with either titanium or chromium orthophosphate.	Titanium	205-213	interleukin 1 beta	Homo sapiens	89-107
9066525-7	1997	Interfacial membrane mononuclear cells also produced high levels of interleukin-1 alpha, interleukin-1 beta, and prostaglandin E2 and expressed bone resorptive activities following stimulation with either titanium or chromium orthophosphate.	chromic phosphate	217-240	interleukin 1 beta	Homo sapiens	89-107
8980284-0	1997	Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP.	Cyclic AMP	76-86	interleukin 1 beta	Homo sapiens	0-17
8980284-9	1997	These data suggest that cAMP acts as a second messenger for IL-1beta-induced inhibition of hair growth.	Cyclic AMP	24-28	interleukin 1 beta	Homo sapiens	60-68
9082044-6	1997	There was an inverse relationship between in vivo tissue levels of IL-1-beta and in vitro responsiveness to nifedipine of fibroblasts derived from that tissue.	Nifedipine	108-118	interleukin 1 beta	Homo sapiens	67-76
9296336-5	1997	The ratio of 1,25(OH)2D/25-OH-D in RA SF, which is presumed to reflect the activity of 25-OH-D-1-hydroxylase (1-OH-ase), was positively correlated with the levels of interleukin-1alpha (IL-1alpha), IL-1beta, and IL-2 in such SF, and was significantly higher than that in sera from RA patients.	25-oh-d	24-31	interleukin 1 beta	Homo sapiens	198-206
9315512-3	1997	Interleukin-1beta (IL-1) enhanced PGE2 production in cultured normal fibroblasts and CRL-1475 cells.	Dinoprostone	34-38	interleukin 1 beta	Homo sapiens	19-23
9315512-4	1997	10(-6) M azelastine inhibited PGE2 production in these IL-1-stimulated fibroblasts.	azelastine	9-19	interleukin 1 beta	Homo sapiens	55-59
9315512-4	1997	10(-6) M azelastine inhibited PGE2 production in these IL-1-stimulated fibroblasts.	Dinoprostone	30-34	interleukin 1 beta	Homo sapiens	55-59
9478092-0	1997	Release of interleukin-1 beta from peripheral blood monocytes and its concentration in the blood serum of the workers employed at the production of chlorfenvinphos.	Chlorfenvinphos	148-163	interleukin 1 beta	Homo sapiens	11-29
9042668-2	1997	We found that IL-1 beta stimulated the proliferation of airway epithelial cells, and this response was inhibited by the IL-1 receptor antagonist and by PD-145065 or BQ-123.	PD 145065	152-161	interleukin 1 beta	Homo sapiens	14-23
9042668-2	1997	We found that IL-1 beta stimulated the proliferation of airway epithelial cells, and this response was inhibited by the IL-1 receptor antagonist and by PD-145065 or BQ-123.	cyclo(Trp-Asp-Pro-Val-Leu)	165-171	interleukin 1 beta	Homo sapiens	14-23
8985172-4	1996	The antagonistic activity of SR 140333 toward SP-induced cytokine production was specific and could not be attributed to a general anti-cytokine effect, since cytokine release induced by another inflammatory protein such as IL-1beta was not blocked by this compound.	SR 140333	29-38	interleukin 1 beta	Homo sapiens	224-232
9194690-0	1997	Methylprednisolone inhibits neutrophil-endothelial cell interactions induced by interleukin-1beta under flow conditions.	Methylprednisolone	0-18	interleukin 1 beta	Homo sapiens	80-97
9194690-1	1997	The effects of methylprednisolone (m-PSL) on IL-1beta-induced neutrophil-endothelial cell interactions, which are normally mediated by increased expression of both intercellular adhesion molecule-1 (ICAM-1) and E-selectin on endothelial cells, were examined using an in vitro flow system.	Methylprednisolone	15-33	interleukin 1 beta	Homo sapiens	45-53
9194690-1	1997	The effects of methylprednisolone (m-PSL) on IL-1beta-induced neutrophil-endothelial cell interactions, which are normally mediated by increased expression of both intercellular adhesion molecule-1 (ICAM-1) and E-selectin on endothelial cells, were examined using an in vitro flow system.	Methylprednisolone	35-40	interleukin 1 beta	Homo sapiens	45-53
9007051-3	1997	In addition to the newly discovered role of ceramide as an intracellular second messenger for tumor necrosis factor-alpha, IL-1beta, and other cytokines, sphingosine, sphingosine-1-phosphate, and other sphingolipid metabolites have recently been demonstrated to modulate cellular calcium homeostasis and cell proliferation.	Ceramides	44-52	interleukin 1 beta	Homo sapiens	123-131
8955085-10	1996	Cycloheximide abolished the TNF-alpha and IL-1beta effect, suggesting that de novo protein synthesis is required for receptor down-regulation.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	42-50
8955085-11	1996	These results suggest that the TNF-alpha and IL-1beta synergize to induce transcriptional down-regulation of the M2 muscarinic receptor, which seems to be mediated through activation of both ceramide and cAMP-dependent protein kinase pathways.	Ceramides	191-199	interleukin 1 beta	Homo sapiens	45-53
8955085-11	1996	These results suggest that the TNF-alpha and IL-1beta synergize to induce transcriptional down-regulation of the M2 muscarinic receptor, which seems to be mediated through activation of both ceramide and cAMP-dependent protein kinase pathways.	Cyclic AMP	204-208	interleukin 1 beta	Homo sapiens	45-53
8940164-0	1996	Manipulation of distinct NFkappaB proteins alters interleukin-1beta-induced human rheumatoid synovial fibroblast prostaglandin E2 formation.	Dinoprostone	113-129	interleukin 1 beta	Homo sapiens	50-67
8986132-8	1996	Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines (IL-1 beta, tumor necrosis factor-alpha and interferon-gamma).	ebselen	0-7	interleukin 1 beta	Homo sapiens	118-156
8986132-8	1996	Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines (IL-1 beta, tumor necrosis factor-alpha and interferon-gamma).	Nitrites	34-41	interleukin 1 beta	Homo sapiens	118-156
9022680-5	1996	We showed that IL-1 beta-mediated induction of NF-kappa B in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates, while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2.	Hydrogen Peroxide	281-285	interleukin 1 beta	Homo sapiens	15-24
8982730-5	1996	Induction of inducible NO synthase in mesangial cells by interleukin-1 beta leads to excessive formation of NO by the cells as measured by nitrite production.	Nitrites	139-146	interleukin 1 beta	Homo sapiens	57-75
8940176-7	1996	Salicylate also inhibited interferon-gamma plus interleukin-1beta-induced NOS 2 mRNA.	Salicylates	0-10	interleukin 1 beta	Homo sapiens	48-65
8940164-6	1996	An NFkappaB classical oligonucleotide decoy produced a concentration-dependent decrease in IL-1-stimulated PGE2 production (IC50 = approximately 2 microM), indicating a role of NFkappaB.	Oligonucleotides	22-37	interleukin 1 beta	Homo sapiens	91-95
8940164-6	1996	An NFkappaB classical oligonucleotide decoy produced a concentration-dependent decrease in IL-1-stimulated PGE2 production (IC50 = approximately 2 microM), indicating a role of NFkappaB.	Dinoprostone	107-111	interleukin 1 beta	Homo sapiens	91-95
8940164-7	1996	Utilization of antisense technology showed that p65 but not p50 or c-Rel mediated IL-1beta-stimulated PGE2 formation.	Dinoprostone	102-106	interleukin 1 beta	Homo sapiens	82-90
8973628-6	1996	Hypoxia had an overall inhibitory effect on cytokine release except for PMA-induced IL-1 beta release, and hypoxia/reoxygenation had a significant up-regulating effect except for a further inhibition of fMLP-induced release of TNF-alpha.	Tetradecanoylphorbol Acetate	72-75	interleukin 1 beta	Homo sapiens	84-93
8942423-4	1996	Production of IL-1 beta and TNF-alpha in the group supplemented with vitamins C and E was significantly higher (P &lt; 0.05) than that of the groups given vitamin E or vitamin C alone.	Ascorbic Acid	69-79	interleukin 1 beta	Homo sapiens	14-23
8968517-5	1996	We found that the release of IL-1 beta was enhanced by titanium, chromium and cobalt, the release of TNF-alpha was enhanced by titanium and chromium, and the release of IL-6 was enhanced by titanium.	Titanium	55-63	interleukin 1 beta	Homo sapiens	29-38
8968517-5	1996	We found that the release of IL-1 beta was enhanced by titanium, chromium and cobalt, the release of TNF-alpha was enhanced by titanium and chromium, and the release of IL-6 was enhanced by titanium.	Chromium	65-73	interleukin 1 beta	Homo sapiens	29-38
8968517-5	1996	We found that the release of IL-1 beta was enhanced by titanium, chromium and cobalt, the release of TNF-alpha was enhanced by titanium and chromium, and the release of IL-6 was enhanced by titanium.	Cobalt	78-84	interleukin 1 beta	Homo sapiens	29-38
8981203-9	1996	Semiquantitative analysis showed that the intragraft interleukin-2 receptor, interleukin-1 beta, and tumor necrosis factor-alpha mRNA levels were lower in posttreatment endomyocardial biopsy specimens from methylprednisolone-reversible rejections than in endomyocardial biopsy specimens from methylprednisolone-irreversible rejections (p = 0.03).	Methylprednisolone	206-224	interleukin 1 beta	Homo sapiens	77-128
9010683-6	1996	Treatment of THP-1 cells with PMA and LPS caused the highest production of both IL-1 beta and IL-6 (&gt; 5ng/ml).	Tetradecanoylphorbol Acetate	30-33	interleukin 1 beta	Homo sapiens	80-89
9172015-0	1996	(+/-)-3-[4-(2-dimethylamino-1-methylethoxy)-phenyl]-1H-pyrazolo[3,4- B]pyridine-1-acetic acid (Y-25510) stimulates production of IL-1 beta and IL-6 at the level of messenger RNA expression in cultured human monocytes.	Y 25510	0-93	interleukin 1 beta	Homo sapiens	129-138
9172015-3	1996	In THP-1 cells, the stimulation of IL-1 beta mRNA expression by Y-25510 was suppressed by cycloheximide, an inhibitor of protein synthesis.	Y 25510	64-71	interleukin 1 beta	Homo sapiens	35-44
9172015-3	1996	In THP-1 cells, the stimulation of IL-1 beta mRNA expression by Y-25510 was suppressed by cycloheximide, an inhibitor of protein synthesis.	Cycloheximide	90-103	interleukin 1 beta	Homo sapiens	35-44
9172015-6	1996	These results demonstrate that Y-25510 stimulates the mRNA expression for IL-1 beta and IL-6 by different mechanisms.	Y 25510	31-38	interleukin 1 beta	Homo sapiens	74-83
9172015-7	1996	Dexamethasone suppressed the LPS-induced expression of mRNA for IL-1 beta and IL-6 in THP-1 cells, whereas the drug never suppressed the mRNA expression for these cytokines in the presence of Y-25510.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	64-73
9172015-8	1996	The result indicates that Y-25510 stimulates the mRNA expression for IL-1 beta and IL-6 by different mechanisms from those of LPS.	Y 25510	26-33	interleukin 1 beta	Homo sapiens	69-78
9172017-0	1996	Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline.	Pentoxifylline	84-98	interleukin 1 beta	Homo sapiens	38-47
9172017-3	1996	We investigated PTX effects on production and mRNA expression of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta and IL-10.	Pentoxifylline	16-19	interleukin 1 beta	Homo sapiens	76-85
9172017-7	1996	Moreover, we observed that depending on the way of activating cells, PTX induced an up- or a down-regulation (in PMA + PHA or LPS stimulated cells, respectively) for IL-1 and IL-6 release.	Pentoxifylline	69-72	interleukin 1 beta	Homo sapiens	166-170
9118901-8	1996	In a similar manner, HQ, via peroxidase oxidation to p-benzoquinone, was capable of preventing the IL-1 beta autocrine stimulation of growth of human B1 myeloid tumor cells by preventing the processing of pre-IL-1 beta to mature cytokine.	quinone	53-67	interleukin 1 beta	Homo sapiens	99-108
9118901-8	1996	In a similar manner, HQ, via peroxidase oxidation to p-benzoquinone, was capable of preventing the IL-1 beta autocrine stimulation of growth of human B1 myeloid tumor cells by preventing the processing of pre-IL-1 beta to mature cytokine.	quinone	53-67	interleukin 1 beta	Homo sapiens	209-218
9118901-9	1996	Benzoquinone was also shown to completely inhibit the ability of the SH-dependent IL-1 beta converting enzyme.	quinone	0-12	interleukin 1 beta	Homo sapiens	82-91
8913883-7	1996	The PGE2 secretagogue, IL-1 beta, down-regulated control levels of IGFBP-3 which could be completely abrogated by pre-incubation with the tyrosine kinase inhibitor, erbstatin, and partially reversed (50 +/- 8%) by KT-5720, a PKA inhibitor.	Dinoprostone	4-8	interleukin 1 beta	Homo sapiens	23-32
8913883-7	1996	The PGE2 secretagogue, IL-1 beta, down-regulated control levels of IGFBP-3 which could be completely abrogated by pre-incubation with the tyrosine kinase inhibitor, erbstatin, and partially reversed (50 +/- 8%) by KT-5720, a PKA inhibitor.	erbstatin	165-174	interleukin 1 beta	Homo sapiens	23-32
8976196-3	1996	Here, we show that human dendritic cells respond to CD40 ligand, as well as to tumor necrosis factor-alpha and IL-1 beta, with intracellular ceramide accumulation, as they are induced to differentiate.	Ceramides	141-149	interleukin 1 beta	Homo sapiens	111-120
8981203-9	1996	Semiquantitative analysis showed that the intragraft interleukin-2 receptor, interleukin-1 beta, and tumor necrosis factor-alpha mRNA levels were lower in posttreatment endomyocardial biopsy specimens from methylprednisolone-reversible rejections than in endomyocardial biopsy specimens from methylprednisolone-irreversible rejections (p = 0.03).	Methylprednisolone	292-310	interleukin 1 beta	Homo sapiens	77-128
9004165-7	1996	Amrinone and pimobendan enhanced IL-1 beta production, whereas vesnarinone had no effect.	Amrinone	0-8	interleukin 1 beta	Homo sapiens	33-42
8982097-0	1996	Recombinant human interleukin 1 beta induces production of prostaglandins in primary human fetal astrocytes and immortalized human fetal astrocyte cultures.	Prostaglandins	59-73	interleukin 1 beta	Homo sapiens	18-36
8982097-3	1996	To better understand the immunopathology of brain injury, we studied the role of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL) 6, IL-2, interferon gamma and IL-1 beta in the production of arachidonic acid metabolites in cells from fetal human brain.	Arachidonic Acid	219-235	interleukin 1 beta	Homo sapiens	188-197
8982097-4	1996	Among these cytokines, only IL-1 beta significantly stimulated production of prostaglandins E2 and F2 alpha but not PGD2, thromboxane B2 and 6-keto-PGF1 alpha.	Dinoprostone	77-94	interleukin 1 beta	Homo sapiens	28-37
8982097-4	1996	Among these cytokines, only IL-1 beta significantly stimulated production of prostaglandins E2 and F2 alpha but not PGD2, thromboxane B2 and 6-keto-PGF1 alpha.	f2 alpha	99-107	interleukin 1 beta	Homo sapiens	28-37
8982097-6	1996	The stimulatory effects of IL-1 beta on the induction of arachidonic acid metabolites have been studied in various human cell types but not in astrocytes.	Arachidonic Acid	57-73	interleukin 1 beta	Homo sapiens	27-36
8982097-7	1996	Human astrocyte production of PGF2 alpha and PGE2 but not PGD2, 6-keto-PGF1 alpha and TXB2 when stimulated by IL-1 beta, is thus a novel finding.	Dinoprost	30-34	interleukin 1 beta	Homo sapiens	110-119
9004165-7	1996	Amrinone and pimobendan enhanced IL-1 beta production, whereas vesnarinone had no effect.	pimobendan	13-23	interleukin 1 beta	Homo sapiens	33-42
8958270-12	1996	During the second week of acute steroid-resistant rejection and lethal infection, a significant rise in IL-1beta, IFN-gamma, and IL-6 was observed (P &lt; or = 0.01 versus control groups).	Steroids	32-39	interleukin 1 beta	Homo sapiens	104-112
8921801-5	1996	Incubation of the cultures with interleukin-1 beta (10 ng/mL) for 24 hours caused a significant increase in nitrite accumulation.	Nitrites	108-115	interleukin 1 beta	Homo sapiens	32-50
8939922-6	1996	In contrast, addition of extracellular ATP promoted IL-1beta posttranslational processing from both monocyte populations.	Adenosine Triphosphate	39-42	interleukin 1 beta	Homo sapiens	52-60
8939922-13	1996	Removal of divalent cations from the medium did not affect the ATP response, but pretreatment of monocytes with the phosphatase inhibitor okadaic acid dose-dependently suppressed ATP-induced IL-1beta posttranslational processing.	Okadaic Acid	138-150	interleukin 1 beta	Homo sapiens	191-199
8939922-13	1996	Removal of divalent cations from the medium did not affect the ATP response, but pretreatment of monocytes with the phosphatase inhibitor okadaic acid dose-dependently suppressed ATP-induced IL-1beta posttranslational processing.	Adenosine Triphosphate	179-182	interleukin 1 beta	Homo sapiens	191-199
8921801-6	1996	Adrenomedullin significantly augmented nitrite production by interleukin-1 beta-stimulated but not by unstimulated cardiac myocytes in a dose-dependent manner (10(-10) to 10(-6) mol/L).	Nitrites	39-46	interleukin 1 beta	Homo sapiens	61-79
8921801-7	1996	The adrenomedullin-induced nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA and protein expression.	Nitrites	27-34	interleukin 1 beta	Homo sapiens	49-67
8921801-8	1996	In the presence of dibutyryl cAMP, the interleukin-1 beta-induced nitrite accumulation was increased further, but the stimulatory effect of adrenomedullin on nitrite production was abolished.	Cyclic AMP	29-33	interleukin 1 beta	Homo sapiens	39-57
8921801-8	1996	In the presence of dibutyryl cAMP, the interleukin-1 beta-induced nitrite accumulation was increased further, but the stimulatory effect of adrenomedullin on nitrite production was abolished.	Nitrites	66-73	interleukin 1 beta	Homo sapiens	39-57
8950199-3	1996	Since reactive oxygen species (ROS) have been implicated in catabolic cytokine action and preliminary data suggested that catabolic cytokines such as TNF-alpha, IL-1 alpha, IL-1 beta and IL-6 are responsible for fibronectin fragment mediated damage, selected anti-oxidants (AOs) were tested as inhibitors of cytokine.	Reactive Oxygen Species	31-34	interleukin 1 beta	Homo sapiens	173-182
8947481-5	1996	In the presence of recombinant human (rh) IL1 beta or rhTNF alpha the increase in PCK mRNA levels was totally inhibited at 0.1 nM glucagon, whereas at 1 nM glucagon the maximal increase was inhibited by only 25%.	Glucagon	130-138	interleukin 1 beta	Homo sapiens	42-50
8947481-5	1996	In the presence of recombinant human (rh) IL1 beta or rhTNF alpha the increase in PCK mRNA levels was totally inhibited at 0.1 nM glucagon, whereas at 1 nM glucagon the maximal increase was inhibited by only 25%.	Glucagon	156-164	interleukin 1 beta	Homo sapiens	42-50
8910464-1	1996	Dipeptides containing fluorescein or biotin have been incorporated into proteolytic substrate cleavage products of bovine serum albumin generated by human cathepsin S or neutrophil elastase and into a fragment of the 31-kDa interleukin 1beta precursor by human interleukin 1beta-converting enzyme.	Dipeptides	0-10	interleukin 1 beta	Homo sapiens	224-241
8910464-1	1996	Dipeptides containing fluorescein or biotin have been incorporated into proteolytic substrate cleavage products of bovine serum albumin generated by human cathepsin S or neutrophil elastase and into a fragment of the 31-kDa interleukin 1beta precursor by human interleukin 1beta-converting enzyme.	Fluorescein	22-33	interleukin 1 beta	Homo sapiens	224-241
9171001-0	1996	In vitro IL-1 beta and TNF-alpha release from THP-1 monocytes in response to metal ions.	Metals	77-82	interleukin 1 beta	Homo sapiens	9-18
8957581-5	1996	Interleukin-1 beta production by lipopolysaccharide-stimulated PBMC was suppressed in a concentration-dependent manner by LVFX, and tumor necrosis factor-alpha production was suppressed at only the highest concentration.	PBMC	63-67	interleukin 1 beta	Homo sapiens	0-18
8895350-0	1996	Protection from nicotinamide inhibition of interleukin-1 beta-induced RIN cell nitric oxide formation is associated with induction of MnSOD enzyme activity.	Niacinamide	16-28	interleukin 1 beta	Homo sapiens	43-61
8895350-0	1996	Protection from nicotinamide inhibition of interleukin-1 beta-induced RIN cell nitric oxide formation is associated with induction of MnSOD enzyme activity.	Nitric Oxide	79-91	interleukin 1 beta	Homo sapiens	43-61
8912909-0	1996	Human olfactory neuroepithelial cells: tyrosine phosphorylation and process extension are increased by the combination of IL-1beta, IL-6, NGF, and bFGF.	Tyrosine	39-47	interleukin 1 beta	Homo sapiens	122-130
8933165-6	1996	TNF-alpha production induced by LPS or IL-1 beta was similarly inhibited by treatment with herbimycin, a tyrosine kinase inhibitor.	herbimycin	91-101	interleukin 1 beta	Homo sapiens	39-48
8958057-8	1996	Induced PGE2 production by monocyte cultures treated with lipopolysaccharide (LPS) or interleukin-1 beta (IL-1 beta) was strongly inhibited in the presence of hrIL-1ra (500 ng/ml).	Dinoprostone	8-12	interleukin 1 beta	Homo sapiens	86-104
8958057-8	1996	Induced PGE2 production by monocyte cultures treated with lipopolysaccharide (LPS) or interleukin-1 beta (IL-1 beta) was strongly inhibited in the presence of hrIL-1ra (500 ng/ml).	Dinoprostone	8-12	interleukin 1 beta	Homo sapiens	106-115
8958057-8	1996	Induced PGE2 production by monocyte cultures treated with lipopolysaccharide (LPS) or interleukin-1 beta (IL-1 beta) was strongly inhibited in the presence of hrIL-1ra (500 ng/ml).	hril-1ra	159-167	interleukin 1 beta	Homo sapiens	86-104
8958057-8	1996	Induced PGE2 production by monocyte cultures treated with lipopolysaccharide (LPS) or interleukin-1 beta (IL-1 beta) was strongly inhibited in the presence of hrIL-1ra (500 ng/ml).	hril-1ra	159-167	interleukin 1 beta	Homo sapiens	106-115
9116194-0	1996	Selegiline stimulates biosynthesis of cytokines interleukin-1 beta and interleukin-6.	Selegiline	0-10	interleukin 1 beta	Homo sapiens	48-66
8896778-2	1996	In addition, recovery from depression following clomipramine (CMI) treatment was accompanied by the restoration of interleukin-1 beta (IL-1 beta) and interleukin-3-like activity (IL-3-LA) to normal range.	Clomipramine	48-60	interleukin 1 beta	Homo sapiens	115-133
8896778-2	1996	In addition, recovery from depression following clomipramine (CMI) treatment was accompanied by the restoration of interleukin-1 beta (IL-1 beta) and interleukin-3-like activity (IL-3-LA) to normal range.	Clomipramine	48-60	interleukin 1 beta	Homo sapiens	135-144
8896778-2	1996	In addition, recovery from depression following clomipramine (CMI) treatment was accompanied by the restoration of interleukin-1 beta (IL-1 beta) and interleukin-3-like activity (IL-3-LA) to normal range.	Clomipramine	62-65	interleukin 1 beta	Homo sapiens	115-133
8896778-2	1996	In addition, recovery from depression following clomipramine (CMI) treatment was accompanied by the restoration of interleukin-1 beta (IL-1 beta) and interleukin-3-like activity (IL-3-LA) to normal range.	Clomipramine	62-65	interleukin 1 beta	Homo sapiens	135-144
9047077-5	1996	This IL-1 beta-mediated induction of ICAM-1 and VCAM-1 expression was significantly inhibited in the presence of a NO donor 3-morpholino-sydnonimine (SIN-1) in a dose-dependent manner.	linsidomine	124-148	interleukin 1 beta	Homo sapiens	5-14
9047079-9	1996	Therefore, LPS and dexamethasone synergism in IL-1r II induction may be important in controlling IL-1 beta effects.	Dexamethasone	19-32	interleukin 1 beta	Homo sapiens	97-106
8961049-10	1996	Cefotaxime (200 mg/L) significantly (P &lt; 0.05) increased the basal levels of IL-1 beta and reduced basal IL-8 concentration after 24 h of incubation.	Cefotaxime	0-10	interleukin 1 beta	Homo sapiens	80-89
9171001-6	1996	METHODS: The release of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) from macrophages was investigated when the macrophages were exposed to metal ions, with or without lipopolysaccharide (LPS), a component of dental plaque.	Metals	170-175	interleukin 1 beta	Homo sapiens	24-42
9171001-6	1996	METHODS: The release of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) from macrophages was investigated when the macrophages were exposed to metal ions, with or without lipopolysaccharide (LPS), a component of dental plaque.	Metals	170-175	interleukin 1 beta	Homo sapiens	44-53
8892627-9	1996	These results suggest that Fas-mediated apoptosis is mediated by ICE cleavage of proteolytic substrates other than IL-1beta and that IL-1beta is an endogenous inhibitor of Fas-mediated apoptosis.	ammonium ferrous sulfate	172-175	interleukin 1 beta	Homo sapiens	133-141
8892627-8	1996	We demonstrated that stably transfected SKW6.4 cells expressing precursor IL-1beta, but not cells transfected with the empty vector, exhibited resistance to Fas-mediated apoptosis due to competitive inhibition of ICE-like activity, which was associated with increased cleavage of precursor IL-1beta to mature IL-1beta.	ammonium ferrous sulfate	157-160	interleukin 1 beta	Homo sapiens	74-82
8903323-5	1996	Whereas cycloheximide and actinomycin D both inhibited BK-induced IL-1beta synthesis, results from Northern blot and nuclear run-on assays suggested that BK acted primarily at the transcription level which led to the accumulation of IL-1beta message in stimulated cells.	Cycloheximide	8-21	interleukin 1 beta	Homo sapiens	66-74
8903323-5	1996	Whereas cycloheximide and actinomycin D both inhibited BK-induced IL-1beta synthesis, results from Northern blot and nuclear run-on assays suggested that BK acted primarily at the transcription level which led to the accumulation of IL-1beta message in stimulated cells.	Dactinomycin	26-39	interleukin 1 beta	Homo sapiens	66-74
8875957-0	1996	Prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with interleukin-1beta.	Prostaglandins	0-13	interleukin 1 beta	Homo sapiens	155-172
8875957-0	1996	Prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with interleukin-1beta.	octadecanoids	78-91	interleukin 1 beta	Homo sapiens	155-172
8875957-0	1996	Prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with interleukin-1beta.	Linoleic Acid	97-110	interleukin 1 beta	Homo sapiens	155-172
8875957-2	1996	Dermal fibroblasts untreated and treated with recombinant IL-1beta were incubated with exogenous labeled linoleic acid.	Linoleic Acid	105-118	interleukin 1 beta	Homo sapiens	58-66
8863511-5	1996	Here, we describe that both IL-1 beta and TNF alpha activate the transcription factor nuclear factor-kappa B (NF-kappa B) via production of reactive oxygen intermediates resulting in ACT expression.	reactive oxygen	140-155	interleukin 1 beta	Homo sapiens	28-37
8875957-5	1996	IL-1beta increased the formation of both 13-HODE and 9-HODE in a concentration-dependent manner with similar EC50 values as for prostanoid formation.	Coriolic acid	41-48	interleukin 1 beta	Homo sapiens	0-8
8875957-5	1996	IL-1beta increased the formation of both 13-HODE and 9-HODE in a concentration-dependent manner with similar EC50 values as for prostanoid formation.	9-hydroxy-10,12-octadecadienoic acid	53-59	interleukin 1 beta	Homo sapiens	0-8
8875957-5	1996	IL-1beta increased the formation of both 13-HODE and 9-HODE in a concentration-dependent manner with similar EC50 values as for prostanoid formation.	Prostaglandins	128-138	interleukin 1 beta	Homo sapiens	0-8
8875957-6	1996	This effect of IL-1beta on HODEs formation was concomitant with the expression of prostaglandin H-synthase-2.	hodes	27-32	interleukin 1 beta	Homo sapiens	15-23
8875957-8	1996	Dexamethasone, actinomycin D, and cycloheximide abolished the effect of IL-1beta on HODEs biosynthesis.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	72-80
8875957-8	1996	Dexamethasone, actinomycin D, and cycloheximide abolished the effect of IL-1beta on HODEs biosynthesis.	Dactinomycin	15-28	interleukin 1 beta	Homo sapiens	72-80
8875957-8	1996	Dexamethasone, actinomycin D, and cycloheximide abolished the effect of IL-1beta on HODEs biosynthesis.	Cycloheximide	34-47	interleukin 1 beta	Homo sapiens	72-80
8875957-8	1996	Dexamethasone, actinomycin D, and cycloheximide abolished the effect of IL-1beta on HODEs biosynthesis.	hodes	84-89	interleukin 1 beta	Homo sapiens	72-80
8875957-11	1996	IL-1beta increased significantly the esterification of 13-HODE in all glycerophospholipids, the major increase being observed in phosphatidylinositol.	Coriolic acid	55-62	interleukin 1 beta	Homo sapiens	0-8
8875957-11	1996	IL-1beta increased significantly the esterification of 13-HODE in all glycerophospholipids, the major increase being observed in phosphatidylinositol.	Glycerophospholipids	70-90	interleukin 1 beta	Homo sapiens	0-8
8875957-11	1996	IL-1beta increased significantly the esterification of 13-HODE in all glycerophospholipids, the major increase being observed in phosphatidylinositol.	Phosphatidylinositols	129-149	interleukin 1 beta	Homo sapiens	0-8
8875957-12	1996	These results indicate that prostaglandin H-synthase-2 is the enzyme responsible for the increase in the ability to form HODEs of dermal fibroblasts stimulated with IL-1beta.	Prostaglandins	28-41	interleukin 1 beta	Homo sapiens	165-173
8914021-9	1996	Stimulation of TGF-beta 1 synthesis by IL-1 beta in D-glucose primed cells was inhibited by cycloheximide but not by actinomycin-D.	Glucose	52-61	interleukin 1 beta	Homo sapiens	39-48
8971655-4	1996	In combination with IL-1 beta, PHT potentiated the inhibitory effect of IL-1 beta on alpha 1 (I) procollagen mRNA level that was accompanied by an increased PGE2 formation.	Phenytoin	31-34	interleukin 1 beta	Homo sapiens	72-81
8971655-4	1996	In combination with IL-1 beta, PHT potentiated the inhibitory effect of IL-1 beta on alpha 1 (I) procollagen mRNA level that was accompanied by an increased PGE2 formation.	Dinoprostone	157-161	interleukin 1 beta	Homo sapiens	72-81
8971655-5	1996	Preincubation with indomethacin (10(-6) M) partially reduced the inhibitory effect of IL-1 beta as well as of IL-1 beta in combination with PHT on the mRNA level of alpha 1 (I) procollagen.	Indomethacin	19-31	interleukin 1 beta	Homo sapiens	86-95
8971655-5	1996	Preincubation with indomethacin (10(-6) M) partially reduced the inhibitory effect of IL-1 beta as well as of IL-1 beta in combination with PHT on the mRNA level of alpha 1 (I) procollagen.	Indomethacin	19-31	interleukin 1 beta	Homo sapiens	110-119
8971655-8	1996	The study indicates that IL-1 reduces the expression of alpha 1 (I) procollagen mRNA in human gingival fibroblasts partly by a prostaglandin endoperoxide (PGH) synthase-mediated pathway and partly by a PGH-synthase independent pathway, whereas PHT reduces alpha 1 (I) procollagen gene expression by a PGH-synthase independent pathway.	Prostaglandin Endoperoxides	127-153	interleukin 1 beta	Homo sapiens	25-29
8971655-8	1996	The study indicates that IL-1 reduces the expression of alpha 1 (I) procollagen mRNA in human gingival fibroblasts partly by a prostaglandin endoperoxide (PGH) synthase-mediated pathway and partly by a PGH-synthase independent pathway, whereas PHT reduces alpha 1 (I) procollagen gene expression by a PGH-synthase independent pathway.	GH2 protein, human	155-158	interleukin 1 beta	Homo sapiens	25-29
8914021-0	1996	Induction of TGF-beta 1 synthesis in D-glucose primed human proximal tubular cells by IL-1 beta and TNF alpha.	Glucose	37-46	interleukin 1 beta	Homo sapiens	86-95
8914021-1	1996	The aim of the present study was to examine whether the induction of TGF-beta 1 synthesis by the pro-inflammatory macrophage derived cytokines, IL-1 beta or TNF alpha, was modified by alterations in D-glucose concentrations.	Glucose	199-208	interleukin 1 beta	Homo sapiens	144-153
8914021-7	1996	Pre-exposure of HPTC to 25 mM D-glucose for 48 hours and subsequent stimulation with IL-1 beta resulted in the secretion of latent TGF-beta 1 in both a time and dose dependent manner.	hptc	16-20	interleukin 1 beta	Homo sapiens	85-94
8914021-9	1996	Stimulation of TGF-beta 1 synthesis by IL-1 beta in D-glucose primed cells was inhibited by cycloheximide but not by actinomycin-D.	Cycloheximide	92-105	interleukin 1 beta	Homo sapiens	39-48
8914021-10	1996	Examination of D-glucose induced TGF-beta 1 mRNA revealed that IL-1 beta, but not TNF alpha, increased the stability of the D-glucose induced transcript.	Glucose	15-24	interleukin 1 beta	Homo sapiens	63-72
8914021-10	1996	Examination of D-glucose induced TGF-beta 1 mRNA revealed that IL-1 beta, but not TNF alpha, increased the stability of the D-glucose induced transcript.	Glucose	124-133	interleukin 1 beta	Homo sapiens	63-72
8914021-11	1996	These results demonstrate that the interaction of D-glucose and IL-1 beta lead to secretion of TGF-beta 1 by HPTC.	hptc	109-113	interleukin 1 beta	Homo sapiens	64-73
8914021-13	1996	This may be explained by the ability of IL-1 beta to stabilize D-glucose-induced TGF-beta 1 mRNA.	Glucose	63-72	interleukin 1 beta	Homo sapiens	40-49
9019718-0	1996	Excitatory sodium currents of NH15-CA2 neuroblastoma x glioma hybrid cells are differently affected by interleukin-2 and interleukin-1beta.	excitatory sodium	0-17	interleukin 1 beta	Homo sapiens	121-138
8831717-2	1996	Rooperol derivatives inhibited the production of tumour necrosis factor-alpha, interleukin-1 beta and interleukin-6.	rooperol	0-8	interleukin 1 beta	Homo sapiens	79-97
8957236-0	1996	Action of anti-inflammatory drugs on interleukin-1 beta-mediated glucose uptake by synoviocytes.	Glucose	65-72	interleukin 1 beta	Homo sapiens	37-55
8957236-4	1996	Whereas non-steroid anti-inflammatory agents were inefficient, cortisol inhibited the action of interleukin-1 beta on glucose uptake.	Glucose	118-125	interleukin 1 beta	Homo sapiens	96-114
8957236-5	1996	In osteoarthritic cells, cortisol, 10(-5) mol/l, reduced interleukin-1 beta-mediated glucose uptake by 27% after a 24-h incubation.	Glucose	85-92	interleukin 1 beta	Homo sapiens	57-75
8957236-9	1996	Cortisol decreased glucose uptake by synoviocytes by acting on basal and interleukin-1 beta-mediated glucose uptake.	Hydrocortisone	0-8	interleukin 1 beta	Homo sapiens	73-91
8957236-9	1996	Cortisol decreased glucose uptake by synoviocytes by acting on basal and interleukin-1 beta-mediated glucose uptake.	Glucose	19-26	interleukin 1 beta	Homo sapiens	73-91
8957236-9	1996	Cortisol decreased glucose uptake by synoviocytes by acting on basal and interleukin-1 beta-mediated glucose uptake.	Glucose	101-108	interleukin 1 beta	Homo sapiens	73-91
8957236-11	1996	The inhibition of interleukin-1 beta-mediated glucose uptake could be proposed as a new model for studying the anti-interleukin-1 beta effects of anti-rheumatic drugs.	Glucose	46-53	interleukin 1 beta	Homo sapiens	18-36
8957236-11	1996	The inhibition of interleukin-1 beta-mediated glucose uptake could be proposed as a new model for studying the anti-interleukin-1 beta effects of anti-rheumatic drugs.	Glucose	46-53	interleukin 1 beta	Homo sapiens	116-134
8871663-4	1996	rhIL-11 pretreatment of thioglycollate-elicited peritoneal macrophages resulted in greater than 60% inhibition of LPS-induced production of TNF-alpha, IL-1beta, IL-12 p40, and nitric oxide.	Thioglycolates	24-38	interleukin 1 beta	Homo sapiens	151-159
8930329-0	1996	Inhibition of peripheral interleukin-1 beta-induced hyperalgesia by the intracerebroventricular administration of diclofenac and alpha-melanocyte-stimulating hormone.	Diclofenac	114-124	interleukin 1 beta	Homo sapiens	25-43
8930329-10	1996	These findings therefore suggest that the hyperalgesia induced by peripheral IL-1 beta can be modulated by a cyclooxygenase pathway of the arachidonate and alpha-MSH in the brain.	Arachidonic Acid	139-151	interleukin 1 beta	Homo sapiens	77-86
8908152-4	1996	Interleukin-1 beta also increased glutathione peroxidase and conjugated diene formation; the latter increased enzyme activity dose-dependently suggesting a possible role for this oxidation product in the induction of glutathione peroxidase activity.	diene	72-77	interleukin 1 beta	Homo sapiens	0-18
8858138-2	1996	This interleukin-1 beta dependent activation is associated with a rapid increase in phosphatidyl inositol 3,4,5 phosphate in renal mesangial cells.	phosphatidyl inositol 3,4,5 phosphate	84-121	interleukin 1 beta	Homo sapiens	5-23
8900430-7	1996	BH101 produced large amounts of IL-1beta, IL-6 and IL-8.	bh101	0-5	interleukin 1 beta	Homo sapiens	32-40
8858138-4	1996	In addition wortmannin partially inhibited IL-1 beta induced PGE2 production and potentiated IL-1 beta induced nitric oxide production.	Wortmannin	12-22	interleukin 1 beta	Homo sapiens	43-52
8858138-4	1996	In addition wortmannin partially inhibited IL-1 beta induced PGE2 production and potentiated IL-1 beta induced nitric oxide production.	Wortmannin	12-22	interleukin 1 beta	Homo sapiens	93-102
8858138-4	1996	In addition wortmannin partially inhibited IL-1 beta induced PGE2 production and potentiated IL-1 beta induced nitric oxide production.	Dinoprostone	61-65	interleukin 1 beta	Homo sapiens	43-52
8858138-4	1996	In addition wortmannin partially inhibited IL-1 beta induced PGE2 production and potentiated IL-1 beta induced nitric oxide production.	Nitric Oxide	111-123	interleukin 1 beta	Homo sapiens	43-52
8858138-4	1996	In addition wortmannin partially inhibited IL-1 beta induced PGE2 production and potentiated IL-1 beta induced nitric oxide production.	Nitric Oxide	111-123	interleukin 1 beta	Homo sapiens	93-102
8876491-0	1996	Interleukin-1 beta and tumor necrosis factor-alpha production by human monocytes cultured with L-thyroxine and thyrocalcitonin: relation to severe root shortening.	Thyroxine	95-106	interleukin 1 beta	Homo sapiens	0-50
8858138-5	1996	These experiments suggest that IL-1 beta can activate PI 3-kinase in renal mesangial cells and that the enzyme plays a role in IL-1 beta induced PGE2 and NO formation in the renal mesangial cell.	Dinoprostone	145-149	interleukin 1 beta	Homo sapiens	31-40
8876491-1	1996	The objectives of this study were to determine whether L-thyroxine (T4) and thyrocalcitonin (TCA) influence monocyte production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) and to examine IL-1 beta and TNF-alpha production in monocytes from a group of orthodontic patients with severe root shortening.	Thyroxine	55-66	interleukin 1 beta	Homo sapiens	131-149
8876491-1	1996	The objectives of this study were to determine whether L-thyroxine (T4) and thyrocalcitonin (TCA) influence monocyte production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) and to examine IL-1 beta and TNF-alpha production in monocytes from a group of orthodontic patients with severe root shortening.	Thyroxine	55-66	interleukin 1 beta	Homo sapiens	151-160
8858138-5	1996	These experiments suggest that IL-1 beta can activate PI 3-kinase in renal mesangial cells and that the enzyme plays a role in IL-1 beta induced PGE2 and NO formation in the renal mesangial cell.	Dinoprostone	145-149	interleukin 1 beta	Homo sapiens	127-136
8897815-1	1996	Preceding the onset of insulin-dependent diabetes mellitus, pancreatic islets are infiltrated by macrophages secreting interleukin-1 beta, which exerts cytotoxic and inhibitory actions on islet beta-cell insulin secretion through induction of nitric oxide (NO) synthesis.	Nitric Oxide	243-255	interleukin 1 beta	Homo sapiens	119-137
8839858-7	1996	On the other hand, a specific tetrapetide-aldehyde inhibitor of ICE significantly retarded the apoptotic death of BMAM cells at 1 mumol/L in 5/6 MDS cases studied (AI% = 2.99 +/- 0.30 in controls v 1.58 +/- 0.40 with ICE-inhibitor, P = .05) and also reduced the levels of active IL-1 beta synthesized (5.59 +/- 2.63 v 2.24 +/- 0.93 pg/10(6) cells, respectively).	tetrapetide	30-41	interleukin 1 beta	Homo sapiens	279-288
8930457-13	1996	Following preoperative (mean 5.09 h) administration of glucocorticosteroids, mitogenic cytokine induction (IL-1 beta, IL-2, sIL-2R and IFN-gamma) was almost completely blocked at the time of transplantation.	glucocorticosteroids	55-75	interleukin 1 beta	Homo sapiens	107-116
8843226-0	1996	Decreased phorbol myristate acetate-induced release of tumor necrosis factor-alpha and interleukin-1 beta from peripheral blood monocytes of patients chronically infected with hepatitis C virus.	Tetradecanoylphorbol Acetate	10-35	interleukin 1 beta	Homo sapiens	87-105
8980876-1	1996	A radicicol analogue (analogue A) was found to inhibit interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) secretion from THP-1 cells.	monorden	2-11	interleukin 1 beta	Homo sapiens	55-73
8980876-1	1996	A radicicol analogue (analogue A) was found to inhibit interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) secretion from THP-1 cells.	monorden	2-11	interleukin 1 beta	Homo sapiens	75-84
8980876-2	1996	If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1 beta but also induced an extremely rapid degradation of IL-1 beta, IL-6 and TNF-alpha mRNA to undetectable levels within 5-8 h. This degradation is independent of translation and of the signal inducing transcription.	monorden	72-81	interleukin 1 beta	Homo sapiens	129-138
8980876-2	1996	If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1 beta but also induced an extremely rapid degradation of IL-1 beta, IL-6 and TNF-alpha mRNA to undetectable levels within 5-8 h. This degradation is independent of translation and of the signal inducing transcription.	monorden	72-81	interleukin 1 beta	Homo sapiens	190-199
8926090-9	1996	Although heat treatment of E. chaffeensis had no effect, periodate treatment completely abolished the ability of E. chaffeensis to induce IL-1beta, IL-8, and IL-10 mRNAs.	metaperiodate	57-66	interleukin 1 beta	Homo sapiens	138-146
8915021-2	1996	When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan.	Triclosan	59-68	interleukin 1 beta	Homo sapiens	109-117
8915021-2	1996	When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan.	Dinoprostone	121-137	interleukin 1 beta	Homo sapiens	73-81
8915021-2	1996	When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan.	Dinoprostone	121-137	interleukin 1 beta	Homo sapiens	109-117
8915021-2	1996	When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan.	Dinoprostone	139-143	interleukin 1 beta	Homo sapiens	73-81
8915021-2	1996	When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan.	Dinoprostone	139-143	interleukin 1 beta	Homo sapiens	109-117
8915021-2	1996	When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan.	Epoprostenol	149-153	interleukin 1 beta	Homo sapiens	73-81
8915021-2	1996	When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan.	Epoprostenol	149-153	interleukin 1 beta	Homo sapiens	109-117
8915021-2	1996	When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan.	Triclosan	206-215	interleukin 1 beta	Homo sapiens	73-81
8915021-2	1996	When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta, the stimulatory effect of IL-1beta on prostaglandin E2 (PGE2) and PGI2 formation was reduced in a dose-dependent manner by triclosan.	Triclosan	206-215	interleukin 1 beta	Homo sapiens	109-117
8915021-4	1996	Furthermore, the capacity of IL-1beta to induce release of [3H] arachidonic acid from prelabelled gingival fibroblasts was reduced in the presence of triclosan.	[3h] arachidonic acid	59-80	interleukin 1 beta	Homo sapiens	29-37
8915021-4	1996	Furthermore, the capacity of IL-1beta to induce release of [3H] arachidonic acid from prelabelled gingival fibroblasts was reduced in the presence of triclosan.	Triclosan	150-159	interleukin 1 beta	Homo sapiens	29-37
8915021-6	1996	The upregulation of the metabolism of AA to PGE2 induced by IL-1beta, was markedly reduced in the presence of triclosan.	Dinoprostone	44-48	interleukin 1 beta	Homo sapiens	60-68
8904645-3	1996	In addition the interaction between cyclic AMP- and cyclic GMP-elevating agonists on the IL-1 beta-stimulated expression of iNOS was examined.	Cyclic AMP	36-46	interleukin 1 beta	Homo sapiens	89-98
8904645-5	1996	Exposure of vascular smooth muscle cells to IL-1 beta stimulated the formation of cyclic AMP but not of cyclic GMP.	Cyclic AMP	82-92	interleukin 1 beta	Homo sapiens	44-53
8904645-6	1996	The intracellular level of cyclic AMP reached a maximum within 1 h and then gradually declined over the next 5 h. This IL-1 beta (60 u ml-1)-stimulated formation of cyclic AMP was modest (about 3 fold at 60 u ml-1 for 1 h) compared to that evoked by isoprenaline (about 9 fold at 3 x 10(-6) M for 2 min).	Cyclic AMP	27-37	interleukin 1 beta	Homo sapiens	119-128
8904645-6	1996	The intracellular level of cyclic AMP reached a maximum within 1 h and then gradually declined over the next 5 h. This IL-1 beta (60 u ml-1)-stimulated formation of cyclic AMP was modest (about 3 fold at 60 u ml-1 for 1 h) compared to that evoked by isoprenaline (about 9 fold at 3 x 10(-6) M for 2 min).	Cyclic AMP	165-175	interleukin 1 beta	Homo sapiens	119-128
8904645-6	1996	The intracellular level of cyclic AMP reached a maximum within 1 h and then gradually declined over the next 5 h. This IL-1 beta (60 u ml-1)-stimulated formation of cyclic AMP was modest (about 3 fold at 60 u ml-1 for 1 h) compared to that evoked by isoprenaline (about 9 fold at 3 x 10(-6) M for 2 min).	Isoproterenol	250-262	interleukin 1 beta	Homo sapiens	119-128
8904645-8	1996	The IL-1 beta (60 u ml-1 for 24 h)-stimulated accumulation of nitrite, which was taken as an index of NO production, was concentration-dependently increased by preferential inhibitors of cyclic AMP-dependent phosphodiesterases (rolipram and trequinsin).	Nitrites	62-69	interleukin 1 beta	Homo sapiens	4-13
8904645-8	1996	The IL-1 beta (60 u ml-1 for 24 h)-stimulated accumulation of nitrite, which was taken as an index of NO production, was concentration-dependently increased by preferential inhibitors of cyclic AMP-dependent phosphodiesterases (rolipram and trequinsin).	Cyclic AMP	187-197	interleukin 1 beta	Homo sapiens	4-13
8904645-13	1996	The level of iNOS protein was markedly increased in smooth muscle cells which had been exposed to IL-1 beta in combination with either rolipram (3 x 10(-6) M) or Sp-8-CPT-cAMPS (10(-4) M) but was reduced in those exposed to IL-1 beta and Rp-8-CPT-cAMPS (10(-4) M).	Rolipram	135-143	interleukin 1 beta	Homo sapiens	98-107
8904645-13	1996	The level of iNOS protein was markedly increased in smooth muscle cells which had been exposed to IL-1 beta in combination with either rolipram (3 x 10(-6) M) or Sp-8-CPT-cAMPS (10(-4) M) but was reduced in those exposed to IL-1 beta and Rp-8-CPT-cAMPS (10(-4) M).	Rolipram	135-143	interleukin 1 beta	Homo sapiens	224-233
8904645-13	1996	The level of iNOS protein was markedly increased in smooth muscle cells which had been exposed to IL-1 beta in combination with either rolipram (3 x 10(-6) M) or Sp-8-CPT-cAMPS (10(-4) M) but was reduced in those exposed to IL-1 beta and Rp-8-CPT-cAMPS (10(-4) M).	3-(1,2-dimethylheptyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo(b,d)pyran-1-ol	162-166	interleukin 1 beta	Homo sapiens	98-107
8904645-17	1996	Similar levels of NF-kappa B-DNA complexes were found in cells which had been exposed to IL-1 beta in combination with either Sp-8-CPT-cAMPS (10(-4) M), trequinsin (10(-6) M) or rolipram (10(-6) M).	Rolipram	178-186	interleukin 1 beta	Homo sapiens	89-98
8904645-25	1996	However, addition of Cys-SNO following the stimulation with IL-1 beta (during the last 5 min of the 30 min exposure period) reduced the level of NF-kappa B-DNA complexes only slightly.	Cysteine	21-24	interleukin 1 beta	Homo sapiens	60-69
8915021-6	1996	The upregulation of the metabolism of AA to PGE2 induced by IL-1beta, was markedly reduced in the presence of triclosan.	Triclosan	110-119	interleukin 1 beta	Homo sapiens	60-68
8915021-7	1996	The study indicates that the stimulatory effect of IL-1beta on prostanoid formation (PGE2, PGI2) in human gingival fibroblasts was diminished in the presence of triclosan partly at the level of phospholipase A2 and partly at the level of cyclooxygenase.	Prostaglandins	63-73	interleukin 1 beta	Homo sapiens	51-59
8915021-7	1996	The study indicates that the stimulatory effect of IL-1beta on prostanoid formation (PGE2, PGI2) in human gingival fibroblasts was diminished in the presence of triclosan partly at the level of phospholipase A2 and partly at the level of cyclooxygenase.	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	51-59
8915021-7	1996	The study indicates that the stimulatory effect of IL-1beta on prostanoid formation (PGE2, PGI2) in human gingival fibroblasts was diminished in the presence of triclosan partly at the level of phospholipase A2 and partly at the level of cyclooxygenase.	Epoprostenol	91-95	interleukin 1 beta	Homo sapiens	51-59
8915021-7	1996	The study indicates that the stimulatory effect of IL-1beta on prostanoid formation (PGE2, PGI2) in human gingival fibroblasts was diminished in the presence of triclosan partly at the level of phospholipase A2 and partly at the level of cyclooxygenase.	Triclosan	161-170	interleukin 1 beta	Homo sapiens	51-59
8887280-4	1996	Exposure of HPMC to spent peritoneal dialysis effluent (PDE) or IL-1 beta resulted in a time- and dose-dependent increase in IL-6 secretion.	Hypromellose Derivatives	12-16	interleukin 1 beta	Homo sapiens	64-73
8895151-5	1996	Indomethacin at 10(-5) M inhibited this IL-1 beta stimulation, but had no effect in the therapeutic range (10(-6)-10(-7) M).	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	40-49
8887296-0	1996	IL-1 beta, a major stimulator of hyaluronan synthesis in vitro of human peritoneal mesothelial cells: relevance to peritonitis in CAPD.	Hyaluronic Acid	33-43	interleukin 1 beta	Homo sapiens	0-9
8798625-5	1996	Dexamethasone prevented the coordinate induction of GTP cyclohydrolase I with NOS2 after exposure to interleukin-1beta and interferon-gamma and also the increase in intracellular BH4 content in cytokine-treated CMEC.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	101-118
8937133-1	1996	UNLABELLED: To investigate the effects of disease modifying antirheumatic drugs (DMARDs) and DEX on production of IL-1 beta, IL-6 and TNF-alpha, synovial cells were observed after IL-1 beta administration in vitro.	Dextromethorphan	93-96	interleukin 1 beta	Homo sapiens	114-123
8964084-6	1996	2",3"-Dideoxyadenosine, which inhibits adenyl cyclase activity, reduced IL-1, IL-6, and IL-10 levels by 29, 15, and 28% respectively.	Dideoxyadenosine	0-22	interleukin 1 beta	Homo sapiens	72-76
8964084-7	1996	HA1004, an inhibitor of PKA, reduced the IL-1 and IL-6 levels by 29 and 27%, respectively.	N-(2-guanidinoethyl)-5-isoquinolinesulfonamide	0-6	interleukin 1 beta	Homo sapiens	41-45
8891602-3	1996	In contrast, on the mononuclear cells obtained from the lupus patients not only did 15-deoxyspergualin inhibit the spontaneous production of polyclonal and anti-DNA IgG antibodies but also suppressed interleukin-1 beta secretion from the monocytes.	gusperimus	84-102	interleukin 1 beta	Homo sapiens	200-218
8805646-6	1996	In IL-2/IL-1 beta-activated NK cells, treatment with antisense oligonucleotides targeting B2 mRNA causes a significant inhibition of both cell proliferation and expression of activation markers (i.e., IL-2R alpha-chain and transferrin receptor).	Oligonucleotides	63-79	interleukin 1 beta	Homo sapiens	8-17
8814313-10	1996	The phosphodiesterase type 4 inhibitor, R-rolipram was found to inhibit both human and mouse TNF production while SB CSAID, novel kinase inhibitor SB 203580 inhibited human IL-1 and TNF as well as mouse TNF.	sb csaid	114-122	interleukin 1 beta	Homo sapiens	173-177
8814313-10	1996	The phosphodiesterase type 4 inhibitor, R-rolipram was found to inhibit both human and mouse TNF production while SB CSAID, novel kinase inhibitor SB 203580 inhibited human IL-1 and TNF as well as mouse TNF.	SB 203580	147-156	interleukin 1 beta	Homo sapiens	173-177
8806608-3	1996	While OM-85 did not induce the classical HSP, we show here, using 2D gel electrophoresis combined with immunoblotting, the induction of the glucose regulated protein grp78 (the immunoglobulin heavy chain binding protein BiP) along with the described accumulation of pro-interleukin-1 beta.	Glucose	140-147	interleukin 1 beta	Homo sapiens	266-288
8782659-0	1996	Regulation of arachidonic acid metabolism, aromatase activity and growth in human breast cancer cells by interleukin-1beta and phorbol ester: dissociation of a mediatory role for prostaglandin E2 in the autocrine control of cell function.	Arachidonic Acid	14-30	interleukin 1 beta	Homo sapiens	105-122
8782659-6	1996	Similarly, growth inhibition and aromatase stimulation in response to TPA were both further enhanced by IL-1beta treatment.	Tetradecanoylphorbol Acetate	70-73	interleukin 1 beta	Homo sapiens	104-112
8782659-9	1996	Dexamethasone alone stimulated aromatase activity and demonstrated a permissive action on aromatase stimulation by IL-1beta and TPA.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	115-123
8826848-3	1996	Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator (uPA), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 (PAI-1) as analysed by zymography, enzyme immunoassays and Northern analysis.	Tetradecanoylphorbol Acetate	200-203	interleukin 1 beta	Homo sapiens	45-63
8782659-10	1996	However, pre-treatment of cells with dexamethasone prevented subsequent induction of aromatase activity by IL-1beta and TPA.	Dexamethasone	37-50	interleukin 1 beta	Homo sapiens	107-115
8782659-11	1996	Our study describes a novel synergistic interaction in response to protein kinase C activation and IL-1beta during the regulation of arachidonate metabolism, cell growth and aromatase activity in human breast cancer cells.	Arachidonic Acid	133-145	interleukin 1 beta	Homo sapiens	99-107
8810643-7	1996	LPS- and IL-1 beta-induced MIP-1 alpha mRNA expression was reduced by 43 +/- 5% (P &lt; 0.01) and 41 +/- 4% (NS).	ns	109-111	interleukin 1 beta	Homo sapiens	9-18
8945019-9	1996	In addition, by combined application of IL-1 beta and TNF alpha binding particles and endotoxin adsorbents, such as cationically modified cellulose, it should be feasible to interfere with the complex pathobiochemical sequelae of sepsis.	Cellulose	138-147	interleukin 1 beta	Homo sapiens	40-49
8826848-3	1996	Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator (uPA), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 (PAI-1) as analysed by zymography, enzyme immunoassays and Northern analysis.	Tetradecanoylphorbol Acetate	200-203	interleukin 1 beta	Homo sapiens	65-74
8930475-3	1996	IL-1 beta increased in the course of both types of contact dermatitis, displaying the highest levels in irritant CD.	Cadmium	113-115	interleukin 1 beta	Homo sapiens	0-9
8917629-6	1996	In monocyte/macrophages the formation of IL-1 beta, IL-12 and tumor necrosis factor alpha is decreased by cAMP or through the increased formation of IL-10, which is up-regulated by cAMP.	Cyclic AMP	106-110	interleukin 1 beta	Homo sapiens	41-50
8917629-6	1996	In monocyte/macrophages the formation of IL-1 beta, IL-12 and tumor necrosis factor alpha is decreased by cAMP or through the increased formation of IL-10, which is up-regulated by cAMP.	Cyclic AMP	181-185	interleukin 1 beta	Homo sapiens	41-50
8954594-16	1996	A third experiment demonstrated that IL-1 (2 micrograms/ kg, ip) significantly increased ACTH and corticosterone release in all prenatal treatment groups.	Corticosterone	98-112	interleukin 1 beta	Homo sapiens	37-41
8954594-17	1996	IL-1-induced corticosterone secretion was attenuated in P offspring, compared to both E and N rats.	Corticosterone	13-27	interleukin 1 beta	Homo sapiens	0-4
8954594-18	1996	Together, these findings indicate that exposure to ethanol in utero produces impairments in mechanisms that mediate the effects of IL-1 on body temperature (particularly during the light period) and ingestive behavior, but not on motor activity and pituitary-adrenal activation.	Ethanol	51-58	interleukin 1 beta	Homo sapiens	131-135
8937690-7	1996	Hence MM-LDL is biologically active and may contribute to the early stages of atherogenesis by stimulating the inflammatory cytokine IL-1 and the efficacy of probucol in inhibiting the progression of atherosclerosis may be due, both to its inhibition of IL-1 expression by intimal macrophages, and its prevention of LDL oxidation.	Probucol	158-166	interleukin 1 beta	Homo sapiens	254-258
8756539-7	1996	NG-Monomethyl-L-arginine, an inhibitor of NO synthesis, inhibited all of these actions of IL-1.	omega-N-Methylarginine	0-24	interleukin 1 beta	Homo sapiens	90-94
8891757-3	1996	In the human osteoblastic cell line MG-63, IL-1 alpha (10-1000 pg/ml), IL-1 beta (3-300 pg/ml) and TNF-alpha (1-30 ng/ml) stimulated prostaglandin E2 (PGE2) formation and inhibited 1,25(OH)2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of type I collagen.	Dinoprostone	133-149	interleukin 1 beta	Homo sapiens	71-80
8891757-7	1996	In these cells, indomethacin and flurbiprofen abolished the effects of IL-1 beta and TNF-alpha on prostaglandin formation without affecting the inhibitory effects of the cytokines on osteocalcin biosynthesis.	Indomethacin	16-28	interleukin 1 beta	Homo sapiens	71-80
8886857-8	1996	IL-1 reduced the TPO content and inhibited the TSH-induced increase in TPO in a concentration-dependent manner.	Thyrotropin	47-50	interleukin 1 beta	Homo sapiens	0-4
8891757-3	1996	In the human osteoblastic cell line MG-63, IL-1 alpha (10-1000 pg/ml), IL-1 beta (3-300 pg/ml) and TNF-alpha (1-30 ng/ml) stimulated prostaglandin E2 (PGE2) formation and inhibited 1,25(OH)2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of type I collagen.	Dinoprostone	151-155	interleukin 1 beta	Homo sapiens	71-80
8891757-7	1996	In these cells, indomethacin and flurbiprofen abolished the effects of IL-1 beta and TNF-alpha on prostaglandin formation without affecting the inhibitory effects of the cytokines on osteocalcin biosynthesis.	Flurbiprofen	33-45	interleukin 1 beta	Homo sapiens	71-80
8891757-3	1996	In the human osteoblastic cell line MG-63, IL-1 alpha (10-1000 pg/ml), IL-1 beta (3-300 pg/ml) and TNF-alpha (1-30 ng/ml) stimulated prostaglandin E2 (PGE2) formation and inhibited 1,25(OH)2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of type I collagen.	Calcitriol	181-201	interleukin 1 beta	Homo sapiens	71-80
8891757-7	1996	In these cells, indomethacin and flurbiprofen abolished the effects of IL-1 beta and TNF-alpha on prostaglandin formation without affecting the inhibitory effects of the cytokines on osteocalcin biosynthesis.	Prostaglandins	98-111	interleukin 1 beta	Homo sapiens	71-80
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Indomethacin	43-55	interleukin 1 beta	Homo sapiens	120-129
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Indomethacin	43-55	interleukin 1 beta	Homo sapiens	208-217
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Flurbiprofen	57-69	interleukin 1 beta	Homo sapiens	120-129
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Flurbiprofen	57-69	interleukin 1 beta	Homo sapiens	208-217
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Naproxen	71-79	interleukin 1 beta	Homo sapiens	120-129
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Naproxen	71-79	interleukin 1 beta	Homo sapiens	208-217
8814146-3	1996	The mechanism of upregulation by IL-1 beta was studied further with respect to proto-oncogene expression and under the treatment of cycloheximide and actinomycin D.	Cycloheximide	132-145	interleukin 1 beta	Homo sapiens	33-42
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Meclofenamic Acid	84-101	interleukin 1 beta	Homo sapiens	120-129
8814146-3	1996	The mechanism of upregulation by IL-1 beta was studied further with respect to proto-oncogene expression and under the treatment of cycloheximide and actinomycin D.	Dactinomycin	150-163	interleukin 1 beta	Homo sapiens	33-42
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Meclofenamic Acid	84-101	interleukin 1 beta	Homo sapiens	208-217
8814146-8	1996	In IL-1 beta, the upregulation of cytokines and receptors was preceded by the upregulation of c-fos, c-jun, and c-myc, and it was inhibited by actinomycin D.	Dactinomycin	143-156	interleukin 1 beta	Homo sapiens	3-12
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Dinoprostone	156-160	interleukin 1 beta	Homo sapiens	120-129
8891757-5	1996	Four non-steroidal antiinflammatory drugs, indomethacin, flurbiprofen, naproxen and meclofenamic acid, inhibited basal, IL-1 beta- and TNF-alpha-stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or TNF-alpha-induced inhibition of osteocalcin and type I collagen formation.	Dinoprostone	156-160	interleukin 1 beta	Homo sapiens	208-217
8891757-6	1996	In isolated, non-transformed, human osteoblast-like cells, IL-1 beta and TNF-alpha stimulated PGE2 formation and concomitantly inhibited 1,25(OH)2-vitamin D3-stimulated osteocalcin biosynthesis, without affecting type I collagen formation.	Dinoprostone	94-98	interleukin 1 beta	Homo sapiens	59-68
8816927-3	1996	Stimulation of system A activity by adaptative regulation is a prerequisite to obtain an increase of MeAIB uptake in IL-1-treated cells, since cells which had been grown in a normal medium did not express stimulation of system A activity when IL-1 was added.	2,2-dimethyl-beta-alanine	101-106	interleukin 1 beta	Homo sapiens	117-121
8816927-4	1996	The IL-1-mediated MeAIB uptake is independent of protein synthesis, since cycloheximide (CHX) did not inhibit MeAIB uptake, and characterized by a decrease in the Michaelis constant K(m) (0.147 vs. 0.270 mmol/l, IL-1 vs. control) and a slight increase in maximal velocity (Vmax) (4.59 vs. 3.89 nmol/mg prot/10 min, IL-1 vs. control).	2,2-dimethyl-beta-alanine	18-23	interleukin 1 beta	Homo sapiens	4-8
8891757-6	1996	In isolated, non-transformed, human osteoblast-like cells, IL-1 beta and TNF-alpha stimulated PGE2 formation and concomitantly inhibited 1,25(OH)2-vitamin D3-stimulated osteocalcin biosynthesis, without affecting type I collagen formation.	Calcitriol	137-157	interleukin 1 beta	Homo sapiens	59-68
8816927-4	1996	The IL-1-mediated MeAIB uptake is independent of protein synthesis, since cycloheximide (CHX) did not inhibit MeAIB uptake, and characterized by a decrease in the Michaelis constant K(m) (0.147 vs. 0.270 mmol/l, IL-1 vs. control) and a slight increase in maximal velocity (Vmax) (4.59 vs. 3.89 nmol/mg prot/10 min, IL-1 vs. control).	2,2-dimethyl-beta-alanine	18-23	interleukin 1 beta	Homo sapiens	212-216
8784069-4	1996	The cytokine combination of interleukin-1 beta (50 U/mL), tumor necrosis factor-alpha (10(3) U/mL), and interferon-gamma (10(3) U/mL) induced significant increases in MDA and nitrite and significant decreases in insulin and DNA in islets after 60-h incubation.	Nitrites	175-182	interleukin 1 beta	Homo sapiens	28-46
8816927-4	1996	The IL-1-mediated MeAIB uptake is independent of protein synthesis, since cycloheximide (CHX) did not inhibit MeAIB uptake, and characterized by a decrease in the Michaelis constant K(m) (0.147 vs. 0.270 mmol/l, IL-1 vs. control) and a slight increase in maximal velocity (Vmax) (4.59 vs. 3.89 nmol/mg prot/10 min, IL-1 vs. control).	2,2-dimethyl-beta-alanine	18-23	interleukin 1 beta	Homo sapiens	212-216
8816927-4	1996	The IL-1-mediated MeAIB uptake is independent of protein synthesis, since cycloheximide (CHX) did not inhibit MeAIB uptake, and characterized by a decrease in the Michaelis constant K(m) (0.147 vs. 0.270 mmol/l, IL-1 vs. control) and a slight increase in maximal velocity (Vmax) (4.59 vs. 3.89 nmol/mg prot/10 min, IL-1 vs. control).	Cycloheximide	74-87	interleukin 1 beta	Homo sapiens	4-8
8816927-4	1996	The IL-1-mediated MeAIB uptake is independent of protein synthesis, since cycloheximide (CHX) did not inhibit MeAIB uptake, and characterized by a decrease in the Michaelis constant K(m) (0.147 vs. 0.270 mmol/l, IL-1 vs. control) and a slight increase in maximal velocity (Vmax) (4.59 vs. 3.89 nmol/mg prot/10 min, IL-1 vs. control).	Cycloheximide	89-92	interleukin 1 beta	Homo sapiens	4-8
8816927-4	1996	The IL-1-mediated MeAIB uptake is independent of protein synthesis, since cycloheximide (CHX) did not inhibit MeAIB uptake, and characterized by a decrease in the Michaelis constant K(m) (0.147 vs. 0.270 mmol/l, IL-1 vs. control) and a slight increase in maximal velocity (Vmax) (4.59 vs. 3.89 nmol/mg prot/10 min, IL-1 vs. control).	2,2-dimethyl-beta-alanine	110-115	interleukin 1 beta	Homo sapiens	4-8
8908619-8	1996	Interleukin-1 beta enhanced PGE2 secretion (P &lt; 0.01) in both POGC and NC, while lipopolysaccharide increased prostaglandin release only by the NC cells.	Dinoprostone	28-32	interleukin 1 beta	Homo sapiens	0-18
8757337-3	1996	An inducible form of cyclo-oxygenase (COX 2) was demonstrated in astrocytes and microglia after IL-1 beta plus IFN-gamma stimulation; since 1) large amounts of PGF2 alpha were released; 2) PGF2 alpha secretion required protein synthesis and was blocked by indomethacin; and 3) the response was delayed and persistent.	Dinoprost	160-164	interleukin 1 beta	Homo sapiens	96-105
8757337-3	1996	An inducible form of cyclo-oxygenase (COX 2) was demonstrated in astrocytes and microglia after IL-1 beta plus IFN-gamma stimulation; since 1) large amounts of PGF2 alpha were released; 2) PGF2 alpha secretion required protein synthesis and was blocked by indomethacin; and 3) the response was delayed and persistent.	Dinoprost	189-193	interleukin 1 beta	Homo sapiens	96-105
8757337-6	1996	Conversely, microglial cells were induced by IL-1 beta and IFN-gamma to generate superoxide anions (O2.-) through an NADPH oxidase-dependent pathway.	Superoxides	81-98	interleukin 1 beta	Homo sapiens	45-54
8757337-6	1996	Conversely, microglial cells were induced by IL-1 beta and IFN-gamma to generate superoxide anions (O2.-) through an NADPH oxidase-dependent pathway.	Superoxides	100-102	interleukin 1 beta	Homo sapiens	45-54
8865289-6	1996	Dexamethasone administered to 10 infants induced rapid decrease in inflammatory cell numbers and concentrations of MIP-1 alpha, tumor necrosis factor-alpha, IL-1 beta, and elastase/alpha-1 antitrypsin.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	157-166
8931118-5	1996	In comparison, dexamethasone, which also inhibits IL-1 beta induction of PGE2, had inhibitory effects on both parameters.	Dinoprostone	73-77	interleukin 1 beta	Homo sapiens	50-59
8891931-0	1996	The effect of tetracycline fiber therapy on beta-glucuronidase and interleukin-1 beta in crevicular fluid.	Tetracycline	14-26	interleukin 1 beta	Homo sapiens	67-85
8898374-7	1996	RESULTS: Interleukin-1 beta (IL-1 beta)-primed A549 cells showed selective elevation in the levels of PGHS-2 mRNA and generated 15-hydroxyeicosatetraenoic acid (15-HETE).	Eicosatetraenoic acid, 15-hydroxy-	128-159	interleukin 1 beta	Homo sapiens	9-27
8898374-7	1996	RESULTS: Interleukin-1 beta (IL-1 beta)-primed A549 cells showed selective elevation in the levels of PGHS-2 mRNA and generated 15-hydroxyeicosatetraenoic acid (15-HETE).	Eicosatetraenoic acid, 15-hydroxy-	128-159	interleukin 1 beta	Homo sapiens	29-38
8898374-7	1996	RESULTS: Interleukin-1 beta (IL-1 beta)-primed A549 cells showed selective elevation in the levels of PGHS-2 mRNA and generated 15-hydroxyeicosatetraenoic acid (15-HETE).	15-Hete	161-168	interleukin 1 beta	Homo sapiens	9-27
8898374-7	1996	RESULTS: Interleukin-1 beta (IL-1 beta)-primed A549 cells showed selective elevation in the levels of PGHS-2 mRNA and generated 15-hydroxyeicosatetraenoic acid (15-HETE).	15-Hete	161-168	interleukin 1 beta	Homo sapiens	29-38
8898374-9	1996	Maximal production of 15-HETE from endogenous sources occurred within 24 hr of cytokine (IL-1 beta) exposure and declined thereafter.	15-Hete	22-29	interleukin 1 beta	Homo sapiens	89-98
8931118-0	1996	Differential effects of 1,25-(OH)2D3 on acyl hydrolase and cyclooxygenase activities in interleukin 1 beta-stimulated human synovial fibroblast cultures.	Calcitriol	24-36	interleukin 1 beta	Homo sapiens	88-106
8931118-2	1996	We have previously shown that interleukin 1 beta (IL-1 beta) induces PGE2 production in synovial fibroblast cultures and that this effect is suppressed by the active metabolite of vitamin D3, 1,25-(OH)2D3.	Dinoprostone	69-73	interleukin 1 beta	Homo sapiens	30-48
8908620-5	1996	The NVD cells produced significantly more amount of PGE2 than the ECS cells and the both cells responded to the addition of IL-1 beta to increase PGE2 production.	Dinoprostone	146-150	interleukin 1 beta	Homo sapiens	124-133
8931118-2	1996	We have previously shown that interleukin 1 beta (IL-1 beta) induces PGE2 production in synovial fibroblast cultures and that this effect is suppressed by the active metabolite of vitamin D3, 1,25-(OH)2D3.	Dinoprostone	69-73	interleukin 1 beta	Homo sapiens	50-59
8908620-6	1996	A specific inhibitor of cyclooxygenase-2 (COX-2), NS398, decreased basal PGE2 production and inhibited the stimulatory effect of IL-1 beta in a dose dependent manner in NVD cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	50-55	interleukin 1 beta	Homo sapiens	129-138
8931118-2	1996	We have previously shown that interleukin 1 beta (IL-1 beta) induces PGE2 production in synovial fibroblast cultures and that this effect is suppressed by the active metabolite of vitamin D3, 1,25-(OH)2D3.	Cholecalciferol	180-190	interleukin 1 beta	Homo sapiens	30-48
8931118-2	1996	We have previously shown that interleukin 1 beta (IL-1 beta) induces PGE2 production in synovial fibroblast cultures and that this effect is suppressed by the active metabolite of vitamin D3, 1,25-(OH)2D3.	Cholecalciferol	180-190	interleukin 1 beta	Homo sapiens	50-59
8931118-2	1996	We have previously shown that interleukin 1 beta (IL-1 beta) induces PGE2 production in synovial fibroblast cultures and that this effect is suppressed by the active metabolite of vitamin D3, 1,25-(OH)2D3.	-(oh)2d3	196-204	interleukin 1 beta	Homo sapiens	30-48
8931118-2	1996	We have previously shown that interleukin 1 beta (IL-1 beta) induces PGE2 production in synovial fibroblast cultures and that this effect is suppressed by the active metabolite of vitamin D3, 1,25-(OH)2D3.	-(oh)2d3	196-204	interleukin 1 beta	Homo sapiens	50-59
8931118-5	1996	In comparison, dexamethasone, which also inhibits IL-1 beta induction of PGE2, had inhibitory effects on both parameters.	Dexamethasone	15-28	interleukin 1 beta	Homo sapiens	50-59
8908620-8	1996	The addition of recombinant soluble human IL-1 receptor (type I) not only blocked the effect of IL-1 beta on PG secretion, but significantly reduced the basal production of PGE2 by NVD cells.	pg	109-111	interleukin 1 beta	Homo sapiens	96-105
8702883-5	1996	Although there was no augmentation in total protein when IL-1beta and phenylephrine were given simultaneously, IL-1beta attenuated the increase in contractile protein mRNAs (skeletal alpha-actin and beta-MHC) in response to phenylephrine.	Phenylephrine	224-237	interleukin 1 beta	Homo sapiens	111-119
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	123-141
8759758-10	1996	The specific IL-1 beta activity in the two preparations was 60 to 85% of the sp.	TFF2 protein, human	4-6	interleukin 1 beta	Homo sapiens	13-22
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	143-152
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	178-187
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tretinoin	44-46	interleukin 1 beta	Homo sapiens	123-141
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tretinoin	44-46	interleukin 1 beta	Homo sapiens	143-152
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tretinoin	44-46	interleukin 1 beta	Homo sapiens	178-187
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 beta	Homo sapiens	37-41
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 beta	Homo sapiens	339-343
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tretinoin	162-164	interleukin 1 beta	Homo sapiens	37-41
8753812-6	1996	Finally, we demonstrated that RA can also enhance IL-1-induced G-CSF production in primary monocytes of human peripheral blood.	Tretinoin	30-32	interleukin 1 beta	Homo sapiens	50-54
8865966-0	1996	Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production.	Ethanol	48-55	interleukin 1 beta	Homo sapiens	106-124
8865966-3	1996	Our data show that in vitro treatment of blood monocytes with a physiologically relevant dose of alcohol (25 mM) results in significantly decreased induction of tumor necrosis factor-alpha (TNF alpha) and interleukin (IL)-1 beta by bacterial stimulation of either Gram-positive [staphylococcal enterotoxin B (SEB), 1 microgram/ml of SEB] or Gram-negative [lipopolysaccharide (LPS), 1 microgram/ml of LPS] origin both at the protein and mRNA levels.	Alcohols	97-104	interleukin 1 beta	Homo sapiens	205-228
8702454-5	1996	Serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), and IL-1 beta normalized within 7 days after the first administration of tretinoin, transiently increased at the time of radiotherapy, increased again after withdrawal of the tretinoin, and decreased again after its reintroduction.	Tretinoin	152-161	interleukin 1 beta	Homo sapiens	83-92
8754734-5	1996	In contrast, treatment of thyrocytes with either interleukin-1 beta (IL-1 beta) or interferon- gamma (IFN gamma) markedly increased Fas antigen expression on thyrocytes, and these effects were inhibited in the presence of TSH.	Thyrotropin	222-225	interleukin 1 beta	Homo sapiens	49-67
8702454-7	1996	This study documents in vivo the ability of all-trans-retinoic acid to down-regulate the release of IL-6, IL-1 beta, and TNF alpha, and illustrates its potential as a therapeutic agent in conditions associated with chronic overproduction of proinflammatory cytokines.	Tretinoin	44-67	interleukin 1 beta	Homo sapiens	106-115
8894440-2	1996	Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma).	Citrulline	0-10	interleukin 1 beta	Homo sapiens	193-202
8894440-2	1996	Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma).	Arginine	27-35	interleukin 1 beta	Homo sapiens	193-202
8853123-7	1996	Addition of the phagocytosis inhibitor cytochalasin B inhibited the morphological changes of the monocytes and reduced interleukin-1 beta production.	Cytochalasin B	39-53	interleukin 1 beta	Homo sapiens	119-137
8670889-6	1996	This order of events was confirmed in macrophages where lactacystin inhibited the proteolytic activation of precursor ICE and the subsequent generation of active interleukin-1beta.	lactacystin	56-67	interleukin 1 beta	Homo sapiens	162-179
8754734-5	1996	In contrast, treatment of thyrocytes with either interleukin-1 beta (IL-1 beta) or interferon- gamma (IFN gamma) markedly increased Fas antigen expression on thyrocytes, and these effects were inhibited in the presence of TSH.	Thyrotropin	222-225	interleukin 1 beta	Homo sapiens	69-78
8754734-7	1996	When thyrocytes stimulated with either IL-1 beta or IFN gamma were treated with anti-Fas IgM mAb, the cells were committed to apoptosis, whereas this apoptotic process was significantly inhibited by the addition of TSH.	Thyrotropin	215-218	interleukin 1 beta	Homo sapiens	39-48
9239666-14	1996	Treatment with IFN/TNF, TNF, and IL-1 also decreased progesterone secretion, although statistical significance was not achieved.	Progesterone	53-65	interleukin 1 beta	Homo sapiens	33-37
8889469-9	1996	Inhibition of RNA synthesis with actinomycin D demonstrated that the rate of degradation of IL-1 beta mRNA was reduced by treatment with TNF alpha.	Dactinomycin	33-46	interleukin 1 beta	Homo sapiens	92-101
8698868-8	1996	After alpha tocopherol supplementation, there were significant decreases in release of reactive oxygen species, lipid oxidation, IL-1 beta secretion, and monocyte-endothelial cell adhesion, both in resting and activated cells compared with baseline and washout phases.	Tocopherols	12-22	interleukin 1 beta	Homo sapiens	129-138
8877773-7	1996	LPS (1000 ng/ml), IL-1 beta (25 ng/ml) and TNF-alpha (100 ng/ml) decreased contractility by 48%, 55% and 65% and augmented cGMP content by 135%, 88% or 70% after long-term treatment (18 h) in cardiomyocytes, without altering contractility or cGMP content after short-term treatment (30 min).	Cyclic GMP	123-127	interleukin 1 beta	Homo sapiens	18-27
8877773-7	1996	LPS (1000 ng/ml), IL-1 beta (25 ng/ml) and TNF-alpha (100 ng/ml) decreased contractility by 48%, 55% and 65% and augmented cGMP content by 135%, 88% or 70% after long-term treatment (18 h) in cardiomyocytes, without altering contractility or cGMP content after short-term treatment (30 min).	Cyclic GMP	242-246	interleukin 1 beta	Homo sapiens	18-27
8877773-11	1996	IL-1 beta and TNF-alpha have direct negative inotropic effects on cardiomyocytes, which are accompanied by an increase in cGMP content.	Cyclic GMP	122-126	interleukin 1 beta	Homo sapiens	0-9
8774705-9	1996	Finally, when MCF-7 cells were treated with IL-1 beta or TNF-alpha in the presence of cycloheximide, transcription of IL-6 mRNA from the endogenous IL-6 gene was observed.	Cycloheximide	86-99	interleukin 1 beta	Homo sapiens	44-53
8757810-6	1996	The major capsular polysaccharide, glucuronoxylomannan, stimulated release of tumor necrosis factor alpha, IL-1beta, and IL-8 in a dose-dependent fashion.	Polysaccharides	19-33	interleukin 1 beta	Homo sapiens	107-115
8757810-6	1996	The major capsular polysaccharide, glucuronoxylomannan, stimulated release of tumor necrosis factor alpha, IL-1beta, and IL-8 in a dose-dependent fashion.	glucuronoxylomannan	35-54	interleukin 1 beta	Homo sapiens	107-115
8663336-8	1996	Finally, antisense oligonucleotides to PKCzeta partially inhibited the IL-1beta-induced PGE2 formation while control sense oligonucleotides were without effect.	Oligonucleotides	19-35	interleukin 1 beta	Homo sapiens	71-79
8880895-4	1996	However, the addition of IL-6 to a medium containing LPS, IL-1 beta, or TNF alpha significantly inhibited the stimulatory effect of those substances on PGI2 production.	Epoprostenol	152-156	interleukin 1 beta	Homo sapiens	58-67
8663336-2	1996	Protein kinase C (PKC) plays a role in signal transduction mediated by interleukin-1beta (IL-1beta) leading to the increase in prostaglandin E2 (PGE2) production.	Dinoprostone	127-143	interleukin 1 beta	Homo sapiens	71-88
8880895-3	1996	The incubation of HPASMC with 10 micrograms/ml of lipopolysaccharide (LPS), 200 U/ml of IL-1 beta, or 500 U/ml of TNF alpha for 24 hr significantly increased the concentration of PGI2 in the medium.	Epoprostenol	179-183	interleukin 1 beta	Homo sapiens	88-97
8663336-2	1996	Protein kinase C (PKC) plays a role in signal transduction mediated by interleukin-1beta (IL-1beta) leading to the increase in prostaglandin E2 (PGE2) production.	Dinoprostone	127-143	interleukin 1 beta	Homo sapiens	90-98
8663336-8	1996	Finally, antisense oligonucleotides to PKCzeta partially inhibited the IL-1beta-induced PGE2 formation while control sense oligonucleotides were without effect.	Dinoprostone	88-92	interleukin 1 beta	Homo sapiens	71-79
8663336-2	1996	Protein kinase C (PKC) plays a role in signal transduction mediated by interleukin-1beta (IL-1beta) leading to the increase in prostaglandin E2 (PGE2) production.	Dinoprostone	145-149	interleukin 1 beta	Homo sapiens	71-88
8663179-4	1996	Both synthetic and natural glucocorticoids dexamethasone (10(-7)-10(-10) M) and hydrocortisone (10(-6)-10(-8) M) inhibited IL-1beta-stimulated IL-8 mRNA expression.	Dexamethasone	43-56	interleukin 1 beta	Homo sapiens	123-131
8663336-2	1996	Protein kinase C (PKC) plays a role in signal transduction mediated by interleukin-1beta (IL-1beta) leading to the increase in prostaglandin E2 (PGE2) production.	Dinoprostone	145-149	interleukin 1 beta	Homo sapiens	90-98
8663336-4	1996	Staurosporine potentiated the effect of IL-1beta on coxII mRNA expression while calphostin C totally inhibited mRNA expression.	Staurosporine	0-13	interleukin 1 beta	Homo sapiens	40-48
8663336-6	1996	Furthermore, incubation of mesangial cells with IL-1beta causes translocation of PKCzeta from cytosol to a presumed membrane compartment, and this translocation phenomenon was not inhibited by incubating the cells with staurosporine but was inhibited with calphostin C. Gel retardation assays also demonstrated that staurosporine did not inhibit the IL-1beta-stimulated binding of nuclear extracts to the NFkappaB motif.	Staurosporine	219-232	interleukin 1 beta	Homo sapiens	48-56
8663336-6	1996	Furthermore, incubation of mesangial cells with IL-1beta causes translocation of PKCzeta from cytosol to a presumed membrane compartment, and this translocation phenomenon was not inhibited by incubating the cells with staurosporine but was inhibited with calphostin C. Gel retardation assays also demonstrated that staurosporine did not inhibit the IL-1beta-stimulated binding of nuclear extracts to the NFkappaB motif.	Staurosporine	316-329	interleukin 1 beta	Homo sapiens	48-56
8702428-0	1996	Retinoic acid regulates differentially the expression of IL-1 beta and IL-1 receptor antagonist (IL-1ra) in PMA-activated human monocytes.	Tretinoin	0-13	interleukin 1 beta	Homo sapiens	57-66
8702428-3	1996	In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes.	Tretinoin	41-43	interleukin 1 beta	Homo sapiens	61-70
8702428-3	1996	In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes.	Tetradecanoylphorbol Acetate	84-109	interleukin 1 beta	Homo sapiens	61-70
8702428-3	1996	In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes.	Tetradecanoylphorbol Acetate	111-114	interleukin 1 beta	Homo sapiens	61-70
8702428-4	1996	RA enhanced gene expression and production of IL-1 beta in PMA-activated monocytes.	Tretinoin	0-2	interleukin 1 beta	Homo sapiens	46-55
8702429-3	1996	The mechanistic studies showed that TQA did not directly inhibit NO radicals and inducible nitric oxide synthase (iNOS) enzyme but suppressed IL-1 beta and iNOS mRNA expression by LPS.	triptoquinone A	36-39	interleukin 1 beta	Homo sapiens	142-151
8663179-8	1996	1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, HCl (50 microM) and staurosporine (1 microM), potent inhibitors of protein kinase C, and genistein (100 microM), a specific protein tyrosine kinase inhibitor blocked IL-1beta-induced IL-8 gene expression.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	0-45	interleukin 1 beta	Homo sapiens	213-221
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	interleukin 1 beta	Homo sapiens	91-99
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	interleukin 1 beta	Homo sapiens	227-235
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	interleukin 1 beta	Homo sapiens	227-235
8663179-4	1996	Both synthetic and natural glucocorticoids dexamethasone (10(-7)-10(-10) M) and hydrocortisone (10(-6)-10(-8) M) inhibited IL-1beta-stimulated IL-8 mRNA expression.	Hydrocortisone	80-94	interleukin 1 beta	Homo sapiens	123-131
8692926-5	1996	These data identify protein kinase c-Raf as a specific molecular target for interleukin 1 beta-stimulated ceramide formation and demonstrate that ceramide is a lipid cofactor participating in regulation of c-Raf activity.	Ceramides	106-114	interleukin 1 beta	Homo sapiens	76-94
8663179-5	1996	The suppressive effect of dexamethasone on IL-1beta-induced IL-8 mRNA was not observed in the presence of cycloheximide (5 microg/ml), indicating that the dexamethasone-mediated repression of IL-8 gene expression also depends on new protein synthesis.	Dexamethasone	26-39	interleukin 1 beta	Homo sapiens	43-51
8692926-5	1996	These data identify protein kinase c-Raf as a specific molecular target for interleukin 1 beta-stimulated ceramide formation and demonstrate that ceramide is a lipid cofactor participating in regulation of c-Raf activity.	Ceramides	146-154	interleukin 1 beta	Homo sapiens	76-94
8663179-5	1996	The suppressive effect of dexamethasone on IL-1beta-induced IL-8 mRNA was not observed in the presence of cycloheximide (5 microg/ml), indicating that the dexamethasone-mediated repression of IL-8 gene expression also depends on new protein synthesis.	Cycloheximide	106-119	interleukin 1 beta	Homo sapiens	43-51
8663179-5	1996	The suppressive effect of dexamethasone on IL-1beta-induced IL-8 mRNA was not observed in the presence of cycloheximide (5 microg/ml), indicating that the dexamethasone-mediated repression of IL-8 gene expression also depends on new protein synthesis.	Dexamethasone	155-168	interleukin 1 beta	Homo sapiens	43-51
8760209-2	1996	If this hypothesis is correct, then inhibition of endogenous IL-1 should reduce both normal sleep and N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP)-induced sleep.	Acetylmuramyl-Alanyl-Isoglutamine	102-141	interleukin 1 beta	Homo sapiens	61-65
8760209-2	1996	If this hypothesis is correct, then inhibition of endogenous IL-1 should reduce both normal sleep and N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP)-induced sleep.	Acetylmuramyl-Alanyl-Isoglutamine	143-146	interleukin 1 beta	Homo sapiens	61-65
8687218-5	1996	This activity was not: affected by the neutralizing antibodies against IFN-alpha, TNF-alpha or IL-1 beta, indicating it is the direct activity of bropirimine without involvement of cytokine production by tumor cells.	bropirimine	146-157	interleukin 1 beta	Homo sapiens	95-104
8818330-6	1996	Depolymerization of microtubules by either nocodazole or colchicine prevented lipopolysaccharide (LPS)- and interleukin-1 beta-induction of NO-dependent cyclic GMP accumulation.	Nocodazole	43-53	interleukin 1 beta	Homo sapiens	108-126
8818330-6	1996	Depolymerization of microtubules by either nocodazole or colchicine prevented lipopolysaccharide (LPS)- and interleukin-1 beta-induction of NO-dependent cyclic GMP accumulation.	Colchicine	57-67	interleukin 1 beta	Homo sapiens	108-126
8674888-5	1996	The accumulation of CEs in macrophages exposed to LDL-ICs is unique to this type of IC and is associated with paradoxical overexpression of LDL receptor and with increased synthesis and release of interleukin 1 beta and tumor necrosis factor (TNF) alpha.	Cholesterol Esters	20-23	interleukin 1 beta	Homo sapiens	197-215
8758154-5	1996	Interleukin-1 beta was increased by heparin (p &lt; 0.05), whereas interleukin-1 receptor antagonist was increased by fentanyl (p &lt; 0.05).	Heparin	36-43	interleukin 1 beta	Homo sapiens	0-18
8758154-6	1996	Protamine blocked the heparin-induced increase in tumour necrosis factor alpha and interleukin-1 beta.	Heparin	22-29	interleukin 1 beta	Homo sapiens	83-101
8841895-0	1996	Prostaglandin E2 potentiates interleukin-1 beta induced interleukin-6 production by human gingival fibroblasts.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	29-47
8675585-5	1996	In BHP cell lines, IFN gamma, IL-1 beta, and TGF beta 1 inhibited [3H]thymidine incorporation and decreased cell number, but TNF alpha stimulated [3H]thymidine incorporation.	Tritium	67-69	interleukin 1 beta	Homo sapiens	30-39
8675585-5	1996	In BHP cell lines, IFN gamma, IL-1 beta, and TGF beta 1 inhibited [3H]thymidine incorporation and decreased cell number, but TNF alpha stimulated [3H]thymidine incorporation.	Thymidine	70-79	interleukin 1 beta	Homo sapiens	30-39
8841895-4	1996	Therefore, the purpose of this study was to determine if PGE2 induced by IL-1 beta could potentiate the IL-6 response by HGF.	Dinoprostone	57-61	interleukin 1 beta	Homo sapiens	73-82
8841895-6	1996	These concentrations of IL-1 beta also induced a small, but significant increase in PGE2 production by HGF.	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	24-33
8841895-10	1996	These results suggest the endogenous PGE2 induced by IL-1 beta plays an important regulatory role in IL 6 production by HGF.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	53-62
8875637-7	1996	IL-1 beta, PMA and ionomycin all stimulated amnion cell PGE2 production as expected.	Dinoprostone	56-60	interleukin 1 beta	Homo sapiens	0-9
8863330-1	1996	OBJECTIVE: To assess effects of the inflammatory cytokines (IL-1-beta, TNF-alpha, TGF-beta 1) and dialysate effluent on synthesis of hyaluronic acid by human peritoneal mesothelial cells (HMC) in in vitro culture.	Hyaluronic Acid	133-148	interleukin 1 beta	Homo sapiens	60-69
8863330-7	1996	RESULTS: Cytokines enhanced synthesis of hyaluronic acid by HMC, and the strongest effect was induced by IL-1.	Hyaluronic Acid	41-56	interleukin 1 beta	Homo sapiens	105-109
8863330-9	1996	Effluent dialysate and IL-1 synergistically enhance synthesis of hyaluronic acid by HMC.	Hyaluronic Acid	65-80	interleukin 1 beta	Homo sapiens	23-27
8693287-5	1996	Anti-oestrogens, tamoxifen and toremifene, stimulated overall cytokine production on a B-cell line (Ball), whereas on a T-cell line (Molt-4) tamoxifen stimulated IL-1 beta, IL-6 and IFN-gamma production and toremifene inhibited it.	Toremifene	31-41	interleukin 1 beta	Homo sapiens	162-171
8693287-5	1996	Anti-oestrogens, tamoxifen and toremifene, stimulated overall cytokine production on a B-cell line (Ball), whereas on a T-cell line (Molt-4) tamoxifen stimulated IL-1 beta, IL-6 and IFN-gamma production and toremifene inhibited it.	Tamoxifen	141-150	interleukin 1 beta	Homo sapiens	162-171
9094444-8	1996	The inhibition of LPS-stimulated IL-1beta production and mRNA expression by glucocorticoids (dexamethasone and cortisol) reaches the same level with glucocorticoids alone or in combination with rIL-1ra.	Dexamethasone	93-106	interleukin 1 beta	Homo sapiens	33-41
9094444-8	1996	The inhibition of LPS-stimulated IL-1beta production and mRNA expression by glucocorticoids (dexamethasone and cortisol) reaches the same level with glucocorticoids alone or in combination with rIL-1ra.	Hydrocortisone	111-119	interleukin 1 beta	Homo sapiens	33-41
8639020-0	1996	N-acetylcysteine inhibits production of tumor necrosis factor alpha and interleukin-1 beta.	Acetylcysteine	0-16	interleukin 1 beta	Homo sapiens	72-90
8662883-4	1996	Inhibition of de novo BH4 synthesis with 2,4-diamino-6-hydroxypyrimidine (DAHP) significantly attenuated iNOS activity as well as mRNA and protein expression in response to interleukin 1beta plus tumor necrosis factor alpha (IL-1beta/TNF-alpha).	sapropterin	22-25	interleukin 1 beta	Homo sapiens	225-233
8662883-4	1996	Inhibition of de novo BH4 synthesis with 2,4-diamino-6-hydroxypyrimidine (DAHP) significantly attenuated iNOS activity as well as mRNA and protein expression in response to interleukin 1beta plus tumor necrosis factor alpha (IL-1beta/TNF-alpha).	2,4-diaminohypoxanthine	41-72	interleukin 1 beta	Homo sapiens	225-233
8662883-4	1996	Inhibition of de novo BH4 synthesis with 2,4-diamino-6-hydroxypyrimidine (DAHP) significantly attenuated iNOS activity as well as mRNA and protein expression in response to interleukin 1beta plus tumor necrosis factor alpha (IL-1beta/TNF-alpha).	2,4-diaminohypoxanthine	74-78	interleukin 1 beta	Homo sapiens	225-233
8662883-5	1996	In contrast, sepiapterin, which provides BH4 through the pterin salvage pathway, strongly potentiated IL-1beta/TNF-alpha-induced iNOS expression and abrogated the inhibitory effect of DAHP.	sepiapterin	13-24	interleukin 1 beta	Homo sapiens	102-110
8662883-5	1996	In contrast, sepiapterin, which provides BH4 through the pterin salvage pathway, strongly potentiated IL-1beta/TNF-alpha-induced iNOS expression and abrogated the inhibitory effect of DAHP.	sapropterin	41-44	interleukin 1 beta	Homo sapiens	102-110
8662883-5	1996	In contrast, sepiapterin, which provides BH4 through the pterin salvage pathway, strongly potentiated IL-1beta/TNF-alpha-induced iNOS expression and abrogated the inhibitory effect of DAHP.	Pterins	18-24	interleukin 1 beta	Homo sapiens	102-110
8662883-9	1996	The effect of BH4 appears to be mediated, at least in part, by an increase in mRNA stability, as indicated by the observation that DAHP shortened, whereas sepiapterin prolonged the half-life of IL-1beta/TNF-alpha-induced iNOS mRNA.	sapropterin	14-17	interleukin 1 beta	Homo sapiens	194-202
8662883-9	1996	The effect of BH4 appears to be mediated, at least in part, by an increase in mRNA stability, as indicated by the observation that DAHP shortened, whereas sepiapterin prolonged the half-life of IL-1beta/TNF-alpha-induced iNOS mRNA.	sepiapterin	155-166	interleukin 1 beta	Homo sapiens	194-202
8691460-1	1996	A series of four structurally related carbocyclic nucleosides (6a, 6b, 10a, and 10b) were synthesized and evaluated for their ability to inhibit tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) production from human primary macrophages.	carbocyclic nucleosides	38-61	interleukin 1 beta	Homo sapiens	186-204
24178685-8	1996	Ang II also inhibited the IL-1beta induced nitrite accumulation by SMCs.	Nitrites	43-50	interleukin 1 beta	Homo sapiens	26-34
8660354-2	1996	Stimulation with interleukin-1 beta for a further 16 h increased the levels of intercellular adhesion molecule-1, and this effect was inhibited by co-incubation with 0.1-1 microM dexamethasone.	Dexamethasone	179-192	interleukin 1 beta	Homo sapiens	17-35
8764139-8	1996	We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets.	Genistein	52-61	interleukin 1 beta	Homo sapiens	87-96
8764139-8	1996	We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets.	herbimycin	66-78	interleukin 1 beta	Homo sapiens	87-96
8764139-8	1996	We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets.	Dinoprostone	171-175	interleukin 1 beta	Homo sapiens	87-96
8764139-8	1996	We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets.	Nitric Oxide	180-192	interleukin 1 beta	Homo sapiens	87-96
11866799-4	1996	Macrolide therapy caused a significant reduction in the percentage of neutrophils, NCA and mean IL-1beta, IL-8 and LTB4 concentration in BAL fluid of the patients.	Macrolides	0-9	interleukin 1 beta	Homo sapiens	96-104
9099936-10	1996	Both spontaneous and up-regulated expression of ICAM-1, LFA-3 and VCAM-1 by IFN-gamma, IL-1beta or 12-o-tetradecanoyl phorbol 13-acetate (TPA) were markedly suppressed by clarithromycin in a dose-dependent manner at concentrations between 0.1 and 10 microg/ml.	Clarithromycin	171-185	interleukin 1 beta	Homo sapiens	87-95
8842524-3	1996	Thrombin-stimulated PGI2 production by HUVEC pretreated with 10 U/mL of IL-1 beta or 200 U/mL of TNF-alpha for 24 h was potentiated, while increases in [Ca2+]i were suppressed.	Epoprostenol	20-24	interleukin 1 beta	Homo sapiens	72-81
8681939-1	1996	The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression.	Tyrosine	41-49	interleukin 1 beta	Homo sapiens	83-101
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Serine	61-67	interleukin 1 beta	Homo sapiens	101-109
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Tritium	217-219	interleukin 1 beta	Homo sapiens	81-99
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Tritium	217-219	interleukin 1 beta	Homo sapiens	101-109
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Sphingomyelins	220-233	interleukin 1 beta	Homo sapiens	81-99
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Sphingomyelins	220-233	interleukin 1 beta	Homo sapiens	101-109
8641202-0	1996	Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis.	Sphingomyelins	30-43	interleukin 1 beta	Homo sapiens	0-18
8641202-0	1996	Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis.	Ceramides	118-126	interleukin 1 beta	Homo sapiens	0-18
8641202-0	1996	Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis.	Progesterone	130-142	interleukin 1 beta	Homo sapiens	0-18
8641202-0	1996	Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis.	Prostaglandins	147-160	interleukin 1 beta	Homo sapiens	0-18
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Tritium	58-60	interleukin 1 beta	Homo sapiens	81-99
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Tritium	58-60	interleukin 1 beta	Homo sapiens	101-109
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Serine	61-67	interleukin 1 beta	Homo sapiens	81-99
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Tritium	217-219	interleukin 1 beta	Homo sapiens	81-99
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Tritium	217-219	interleukin 1 beta	Homo sapiens	101-109
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Ceramides	291-299	interleukin 1 beta	Homo sapiens	81-99
8641202-1	1996	In granulosa cells labeled to isotopic steady-state with [3H]serine, addition of interleukin-1 beta (IL1 beta) or bacterial sphingomyelinase (SMase) induced a rapid decrease (approximately 60% by 10 min) in cellular [3H]Sphingomyelin content and a prolonged generation (up to 60 min) of [3H]ceramide, the immediate lipid-moiety generated in response to sphingomyelin hydrolysis.	Ceramides	291-299	interleukin 1 beta	Homo sapiens	101-109
8641202-2	1996	In FSH-treated cells, IL1 beta (0.3-30 ng/ml) inhibited progesterone biosynthesis in a dose-dependent manner, an effect that was also observed in cells exposed to increasing concentrations of bacterial SMase (0.003-0.3 U/ml) or the membrane-permeable ceramide analogue N-hexanoylsphingosine (C6-cer:0.1-10 microM).	Progesterone	56-68	interleukin 1 beta	Homo sapiens	22-30
8681939-1	1996	The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression.	Tyrosine	41-49	interleukin 1 beta	Homo sapiens	103-112
8641202-2	1996	In FSH-treated cells, IL1 beta (0.3-30 ng/ml) inhibited progesterone biosynthesis in a dose-dependent manner, an effect that was also observed in cells exposed to increasing concentrations of bacterial SMase (0.003-0.3 U/ml) or the membrane-permeable ceramide analogue N-hexanoylsphingosine (C6-cer:0.1-10 microM).	Ceramides	251-259	interleukin 1 beta	Homo sapiens	22-30
8641202-2	1996	In FSH-treated cells, IL1 beta (0.3-30 ng/ml) inhibited progesterone biosynthesis in a dose-dependent manner, an effect that was also observed in cells exposed to increasing concentrations of bacterial SMase (0.003-0.3 U/ml) or the membrane-permeable ceramide analogue N-hexanoylsphingosine (C6-cer:0.1-10 microM).	N-caproylsphingosine	269-290	interleukin 1 beta	Homo sapiens	22-30
8681939-1	1996	The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression.	Dinoprostone	195-211	interleukin 1 beta	Homo sapiens	83-101
8641202-2	1996	In FSH-treated cells, IL1 beta (0.3-30 ng/ml) inhibited progesterone biosynthesis in a dose-dependent manner, an effect that was also observed in cells exposed to increasing concentrations of bacterial SMase (0.003-0.3 U/ml) or the membrane-permeable ceramide analogue N-hexanoylsphingosine (C6-cer:0.1-10 microM).	N-caproylsphingosine	292-298	interleukin 1 beta	Homo sapiens	22-30
8681939-1	1996	The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression.	Dinoprostone	195-211	interleukin 1 beta	Homo sapiens	103-112
8641202-5	1996	As determined by RT-PCR analysis, the inhibitory effect of IL1 beta, SMase, or C6-cer on gonadotropin-stimulated steroidogenesis was accompanied by arrested transcription of the mitochondrial cholesterol side chain cleavage enzyme (P450scc) and 3 beta-hydroxysteroid dehydrogenase/delta 5-4isomerase, the two FSH-inducible steps involved in progesterone biosynthesis.	Cholesterol	192-203	interleukin 1 beta	Homo sapiens	59-67
8681939-1	1996	The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression.	Dinoprostone	213-217	interleukin 1 beta	Homo sapiens	83-101
8641202-7	1996	Although the effect on PGHS-2 messenger RNA may account for the facilitatory role of ceramide on IL1 beta-induced PGE2 biosynthesis, neither SMase nor the membrane-permeant ceramide analogue were able to augment prostaglandin accumulation in the presence of exogenously added arachidonate precursor.	Ceramides	85-93	interleukin 1 beta	Homo sapiens	97-105
8641202-7	1996	Although the effect on PGHS-2 messenger RNA may account for the facilitatory role of ceramide on IL1 beta-induced PGE2 biosynthesis, neither SMase nor the membrane-permeant ceramide analogue were able to augment prostaglandin accumulation in the presence of exogenously added arachidonate precursor.	Dinoprostone	114-118	interleukin 1 beta	Homo sapiens	97-105
8681939-1	1996	The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression.	Dinoprostone	213-217	interleukin 1 beta	Homo sapiens	103-112
8641202-8	1996	Collectively, whereas these results show that ceramide triggers a negative-effector pathway that is both necessary and sufficient to reproduce the inhibitory effect of IL1 beta on FSH-stimulated granulosa cell steroidogenesis, they also support the notion that sphingomyelin hydrolysis may be important for cytokine-induced PGHS-2 expression but not sufficient to reproduce IL1 beta-stimulated PGE2 biosynthesis.	Ceramides	46-54	interleukin 1 beta	Homo sapiens	168-176
8641202-8	1996	Collectively, whereas these results show that ceramide triggers a negative-effector pathway that is both necessary and sufficient to reproduce the inhibitory effect of IL1 beta on FSH-stimulated granulosa cell steroidogenesis, they also support the notion that sphingomyelin hydrolysis may be important for cytokine-induced PGHS-2 expression but not sufficient to reproduce IL1 beta-stimulated PGE2 biosynthesis.	Ceramides	46-54	interleukin 1 beta	Homo sapiens	374-382
8641202-8	1996	Collectively, whereas these results show that ceramide triggers a negative-effector pathway that is both necessary and sufficient to reproduce the inhibitory effect of IL1 beta on FSH-stimulated granulosa cell steroidogenesis, they also support the notion that sphingomyelin hydrolysis may be important for cytokine-induced PGHS-2 expression but not sufficient to reproduce IL1 beta-stimulated PGE2 biosynthesis.	Sphingomyelins	261-274	interleukin 1 beta	Homo sapiens	168-176
8641202-8	1996	Collectively, whereas these results show that ceramide triggers a negative-effector pathway that is both necessary and sufficient to reproduce the inhibitory effect of IL1 beta on FSH-stimulated granulosa cell steroidogenesis, they also support the notion that sphingomyelin hydrolysis may be important for cytokine-induced PGHS-2 expression but not sufficient to reproduce IL1 beta-stimulated PGE2 biosynthesis.	Dinoprostone	394-398	interleukin 1 beta	Homo sapiens	168-176
8649360-0	1996	D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells.	tricyclodecane-9-yl-xanthogenate	0-4	interleukin 1 beta	Homo sapiens	71-89
8840155-5	1996	The time-course of the IL-1 beta response differed from that of IL-1 alpha and TNF-alpha, in that there was an early (by 6 h after urushiol administration) elevation in IL-1 beta mRNA that occurred before there was evidence of inflammation and had returned to background levels by 72 h when the reaction had reached its peak.	urushiol	131-139	interleukin 1 beta	Homo sapiens	23-32
8666820-9	1996	They were, however, at least partially charge mediated, since heparin abolished the effects of MBP on IL-1-stimulated cells, and the surrogate cationic molecule poly-L-arginine mimicked the stimulatory effects of MBP on fibroblast IL-6-type cytokine elaboration.	Heparin	62-69	interleukin 1 beta	Homo sapiens	102-106
8782124-2	1996	METHODS: SF inhibitor of IL-1 alpha (SFI alpha) was partially purified by ammonium sulfate precipitation, gel filtration, anion exchange chromatography, and chromatofocusing.	Ammonium Sulfate	74-90	interleukin 1 beta	Homo sapiens	25-29
8649360-0	1996	D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells.	Phosphatidylcholines	8-27	interleukin 1 beta	Homo sapiens	71-89
8649360-3	1996	We investigated the role of phosphatidylcholine-specific phospholipase C in the induction of VCAM-1 gene expression by interleukin-1 beta.	Phosphatidylcholines	28-47	interleukin 1 beta	Homo sapiens	119-137
8623935-14	1996	Our results demonstrate that HPMCs synthesize the TGF-beta isoforms 1 and 2 and that the levels of mRNA and protein release can be up-regulated by the proinflammatory cytokine IL-1 beta.	hpmcs	29-34	interleukin 1 beta	Homo sapiens	176-185
8806115-0	1996	Interleukin-1 beta-mediated glucose uptake by chondrocytes.	Glucose	28-35	interleukin 1 beta	Homo sapiens	0-18
8806115-2	1996	The aim of this study was to investigate the in vitro effects of interleukin-1 beta (IL-1 beta) on cultured human articular chondrocytes from patients with osteoarthritis, by the evaluation of glucose uptake.	Glucose	193-200	interleukin 1 beta	Homo sapiens	65-83
8806115-2	1996	The aim of this study was to investigate the in vitro effects of interleukin-1 beta (IL-1 beta) on cultured human articular chondrocytes from patients with osteoarthritis, by the evaluation of glucose uptake.	Glucose	193-200	interleukin 1 beta	Homo sapiens	85-94
8806115-3	1996	We also investigated the inhibitory effect of cortisol on IL-1 beta-mediated glucose uptake.	Glucose	77-84	interleukin 1 beta	Homo sapiens	58-67
8806115-7	1996	Glucose uptake stimulation was observed 3 h after the addition of 100 pg/ml IL-1 beta (+70%) and increased up to 24 h (+145%).	Glucose	0-7	interleukin 1 beta	Homo sapiens	76-85
8806115-10	1996	Cortisol inhibited the action of IL-1 beta on glucose uptake because it reduced stimulating effects by 28% at concentrations as weak as 10(-6) mol/l.	Glucose	46-53	interleukin 1 beta	Homo sapiens	33-42
8806115-14	1996	The inhibition of IL-1 beta-mediated glucose uptake is suggested for studying the anti-IL-1 effect of other anti-rheumatic drugs.	Glucose	37-44	interleukin 1 beta	Homo sapiens	18-27
8967514-3	1996	We found that IL-1 beta significantly increased thymidine incorporation into and cell count of ASM cells in a concentration-dependent manner.	Thymidine	48-57	interleukin 1 beta	Homo sapiens	14-23
8967514-4	1996	Pretreatment of cells with specific polyclonal antibodies against platelet-derived growth factor (PDGF-BB homodimer) completely inhibited the IL-1 beta-induced increase in thymidine incorporation.	Thymidine	172-181	interleukin 1 beta	Homo sapiens	142-151
8967514-7	1996	Pretreatment of cells with genistein (0.37 microM), a specific tyrosine kinase inhibitor, attenuated the proliferative effect of IL-1 beta and PDGF-BB.	Genistein	27-36	interleukin 1 beta	Homo sapiens	129-138
8967514-8	1996	To clarify whether these growth stimuli (IL-1 beta and PDGF-BB) activated phospholipase C (PLC), we examined the formation of phosphatidylinositols.	Phosphatidylinositols	126-147	interleukin 1 beta	Homo sapiens	41-50
8967514-10	1996	In contrast, genistein pretreatment (0.37 microM) prevented formation of inositol 1,4,5-trisphosphate (IP3), as induced by IL-1 beta and/or PDGF-BB.	Genistein	13-22	interleukin 1 beta	Homo sapiens	123-132
8967514-10	1996	In contrast, genistein pretreatment (0.37 microM) prevented formation of inositol 1,4,5-trisphosphate (IP3), as induced by IL-1 beta and/or PDGF-BB.	Inositol 1,4,5-Trisphosphate	73-101	interleukin 1 beta	Homo sapiens	123-132
8967514-10	1996	In contrast, genistein pretreatment (0.37 microM) prevented formation of inositol 1,4,5-trisphosphate (IP3), as induced by IL-1 beta and/or PDGF-BB.	Inositol 1,4,5-Trisphosphate	103-106	interleukin 1 beta	Homo sapiens	123-132
8967514-11	1996	This study demonstrates that both IL-1 beta and PDGF-BB could induce proliferation of ASM cells through the activation of tyrosine kinase and PLC, which in turn stimulate the formation of IP3, a second messenger molecule.	Inositol 1,4,5-Trisphosphate	188-191	interleukin 1 beta	Homo sapiens	34-43
8705664-0	1996	Elevated concentrations of interleukin-1 beta and interleukin-1 receptor antagonist in plasma of women with silicone breast implants.	Silicones	108-116	interleukin 1 beta	Homo sapiens	27-45
8873235-8	1996	ASA provokes an increase in 5-HETE biosynthesis by amnion cells: control media 2.60 +/- 1.5, ASA treatment alone 5.17 +/- 0.20, IL-1 beta alone 6.39 +/- 2.1, and ASA + IL-1 beta 8.95 +/- 1.2 (mean +/- SEM) picograms per microgram protein per 16 hours.	Aspirin	0-3	interleukin 1 beta	Homo sapiens	128-137
8873235-8	1996	ASA provokes an increase in 5-HETE biosynthesis by amnion cells: control media 2.60 +/- 1.5, ASA treatment alone 5.17 +/- 0.20, IL-1 beta alone 6.39 +/- 2.1, and ASA + IL-1 beta 8.95 +/- 1.2 (mean +/- SEM) picograms per microgram protein per 16 hours.	Aspirin	0-3	interleukin 1 beta	Homo sapiens	168-177
8635505-4	1996	We showed that CS-induced shedding of the EBP or internalization of this receptor after saturation with elastin-derived peptides (kappa-elastin, kappa-El) stimulated fibronectin production in cultures of coronary artery SMC to a level observed with recombinant interleukin (IL)-1beta.	Chondroitin Sulfates	15-17	interleukin 1 beta	Homo sapiens	261-283
8639429-3	1996	To explore this we used a functional assay to study the effect of ATRA treatment on the adhesion of blast cells to cultured human endothelial cells (EC), endothelial cell matrix (ECM), and interleukin 1beta-activated EC (IL1 + EC).	Tretinoin	66-70	interleukin 1 beta	Homo sapiens	189-206
8639429-3	1996	To explore this we used a functional assay to study the effect of ATRA treatment on the adhesion of blast cells to cultured human endothelial cells (EC), endothelial cell matrix (ECM), and interleukin 1beta-activated EC (IL1 + EC).	Tretinoin	66-70	interleukin 1 beta	Homo sapiens	221-224
8628285-4	1996	We now report an element termed LILRE (lipopolysaccharide [LPS] and IL-1-responsive element) in the human prointerleukin 1beta gene (IL1B) which can be immediately induced by either lipopolysaccharide (LPS) or IL-1 protein to bind a tyrosine-phosphorylated protein.	Tyrosine	233-241	interleukin 1 beta	Homo sapiens	68-72
8731145-5	1996	The HA/TCP particles dried at 110 degrees C were the most biologically active, stimulating significant release of interleukin 1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha, and prostaglandin E2 (PGE2), products implicated as important mediators of inflammation in diverse pathologic conditions.	Durapatite	4-6	interleukin 1 beta	Homo sapiens	114-132
8731145-5	1996	The HA/TCP particles dried at 110 degrees C were the most biologically active, stimulating significant release of interleukin 1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha, and prostaglandin E2 (PGE2), products implicated as important mediators of inflammation in diverse pathologic conditions.	Durapatite	4-6	interleukin 1 beta	Homo sapiens	134-143
8731145-5	1996	The HA/TCP particles dried at 110 degrees C were the most biologically active, stimulating significant release of interleukin 1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha, and prostaglandin E2 (PGE2), products implicated as important mediators of inflammation in diverse pathologic conditions.	N-(3,4,5-trichlorophenyl)succinimide	7-10	interleukin 1 beta	Homo sapiens	114-132
8731145-5	1996	The HA/TCP particles dried at 110 degrees C were the most biologically active, stimulating significant release of interleukin 1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha, and prostaglandin E2 (PGE2), products implicated as important mediators of inflammation in diverse pathologic conditions.	N-(3,4,5-trichlorophenyl)succinimide	7-10	interleukin 1 beta	Homo sapiens	134-143
8628285-4	1996	We now report an element termed LILRE (lipopolysaccharide [LPS] and IL-1-responsive element) in the human prointerleukin 1beta gene (IL1B) which can be immediately induced by either lipopolysaccharide (LPS) or IL-1 protein to bind a tyrosine-phosphorylated protein.	Tyrosine	233-241	interleukin 1 beta	Homo sapiens	106-126
8628285-4	1996	We now report an element termed LILRE (lipopolysaccharide [LPS] and IL-1-responsive element) in the human prointerleukin 1beta gene (IL1B) which can be immediately induced by either lipopolysaccharide (LPS) or IL-1 protein to bind a tyrosine-phosphorylated protein.	Tyrosine	233-241	interleukin 1 beta	Homo sapiens	133-137
8628285-4	1996	We now report an element termed LILRE (lipopolysaccharide [LPS] and IL-1-responsive element) in the human prointerleukin 1beta gene (IL1B) which can be immediately induced by either lipopolysaccharide (LPS) or IL-1 protein to bind a tyrosine-phosphorylated protein.	Tyrosine	233-241	interleukin 1 beta	Homo sapiens	210-214
9812753-0	1996	Inhibitory effect of quercetin on tumor necrosis factor and interleukin-1 beta pro-osteoclastic activities.	Quercetin	21-30	interleukin 1 beta	Homo sapiens	60-78
9812753-1	1996	AIM: To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin-1 beta (IL-1 beta) pro-osteoclastic activities.	Quercetin	29-38	interleukin 1 beta	Homo sapiens	74-92
9812753-1	1996	AIM: To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin-1 beta (IL-1 beta) pro-osteoclastic activities.	Quercetin	29-38	interleukin 1 beta	Homo sapiens	94-103
9812753-3	1996	RESULTS: Quercetin 5-40 mumol.L-1 reduced the inhibition of cell proliferation and AIP activity induced by TNF or IL-1 beta in a concentration-dependent manner.	Quercetin	9-18	interleukin 1 beta	Homo sapiens	114-123
9812753-5	1996	CONCLUSION: quercetin exerted a marked inhibitory effect on TNF and IL-1 activities, related to their pro-osteoclastic function.	Quercetin	12-21	interleukin 1 beta	Homo sapiens	68-72
8605321-6	1996	We show here that, in endothelial cells, human Al is rapidly inducible by phorbol ester and the inflammatory cytokines, tumor necrosis factor-alpha and interleukin-1beta, but not by the growth factors, basic fibroblast growth factor or vascular endothelial growth factor.	Aluminum	47-49	interleukin 1 beta	Homo sapiens	152-169
8731107-12	1996	FCCP blocked the cellular production of IL-1 alpha, IL-1 beta, and TNF-alpha, but had little effect on zinc-induced stimulated mononuclear cell supernatant calcitriol levels.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	0-4	interleukin 1 beta	Homo sapiens	52-61
8621602-0	1996	Regulatory role of ceramide in interleukin (IL)-1 beta-induced E-selectin expression in human umbilical vein endothelial cells.	Ceramides	19-27	interleukin 1 beta	Homo sapiens	31-54
8621602-1	1996	Ceramide enhances IL-1 beta action, but is not sufficient for E-selectin expression.	Ceramides	0-8	interleukin 1 beta	Homo sapiens	18-27
8621602-5	1996	C2-ceramide at 5 micron enhanced interleukin-1 beta (IL-1 beta)-induced E-selectin expression 2.7-fold, whereas other sphingolipids tested had no effects on this process.	N-acetylsphingosine	0-11	interleukin 1 beta	Homo sapiens	33-51
8621602-5	1996	C2-ceramide at 5 micron enhanced interleukin-1 beta (IL-1 beta)-induced E-selectin expression 2.7-fold, whereas other sphingolipids tested had no effects on this process.	N-acetylsphingosine	0-11	interleukin 1 beta	Homo sapiens	53-62
8621602-7	1996	Northern blot analyses revealed that C2-ceramide and sphingomyelinase increased interleukin-1 beta-induced E-selectin gene transcription levels.	N-acetylsphingosine	37-48	interleukin 1 beta	Homo sapiens	80-98
8621602-8	1996	C2-ceramide and sphingomyelinase induced NF-kappaB activation by themselves and enhanced activation by IL-1 beta, which is essential for E-selectin expression.	N-acetylsphingosine	0-11	interleukin 1 beta	Homo sapiens	103-112
8626598-1	1996	Previously we showed that interleukin 1 beta stimulates the conversion of sphingomyelin to ceramide in the caveolae fraction of normal human fibroblasts.	Sphingomyelins	74-87	interleukin 1 beta	Homo sapiens	26-44
8626598-1	1996	Previously we showed that interleukin 1 beta stimulates the conversion of sphingomyelin to ceramide in the caveolae fraction of normal human fibroblasts.	Ceramides	91-99	interleukin 1 beta	Homo sapiens	26-44
8817534-4	1996	Tenidap, naproxen and meloxicam inhibited the IL-1 beta-induced synthesis of IL-6, whereas ibuprofen, piroxicam, diclofenac and indomethacin had no effect.	Naproxen	9-17	interleukin 1 beta	Homo sapiens	46-55
8817534-4	1996	Tenidap, naproxen and meloxicam inhibited the IL-1 beta-induced synthesis of IL-6, whereas ibuprofen, piroxicam, diclofenac and indomethacin had no effect.	Meloxicam	22-31	interleukin 1 beta	Homo sapiens	46-55
8621602-9	1996	Immunological analyses with anti-NF-kappaB antibodies showed that subunit composition of NF-kappaB activated by IL-1 beta differs from that activated by C2-ceramide, suggesting that signaling pathways utilized by these stimuli may be different.	N-acetylsphingosine	153-164	interleukin 1 beta	Homo sapiens	112-121
8967341-8	1996	The protein synthesis inhibitors and okadaic acid potentiated the IL-1 beta-induced JNK activity.	Okadaic Acid	37-49	interleukin 1 beta	Homo sapiens	66-75
8621602-11	1996	IL-1 beta induced sphingomyelin hydrolysis to ceramide; intracellular ceramide level increased to 182% of control value at 30 min.	Sphingomyelins	18-31	interleukin 1 beta	Homo sapiens	0-9
8621602-11	1996	IL-1 beta induced sphingomyelin hydrolysis to ceramide; intracellular ceramide level increased to 182% of control value at 30 min.	Ceramides	46-54	interleukin 1 beta	Homo sapiens	0-9
8621602-11	1996	IL-1 beta induced sphingomyelin hydrolysis to ceramide; intracellular ceramide level increased to 182% of control value at 30 min.	Ceramides	70-78	interleukin 1 beta	Homo sapiens	0-9
8621602-12	1996	Taken together, these findings suggest that (i) sphingomyelin hydrolysis to ceramide does not trigger, but rather enhances cytokine-induced E-selectin expression, in part through NF-kappaB; (ii) sphingomyelin hydrolysis to ceramide does not mediate all the effects of IL-1 beta, although it may play important roles in IL-1 beta signal transduction in human umbilical vein endothelial cells.	Sphingomyelins	48-61	interleukin 1 beta	Homo sapiens	268-277
8621602-12	1996	Taken together, these findings suggest that (i) sphingomyelin hydrolysis to ceramide does not trigger, but rather enhances cytokine-induced E-selectin expression, in part through NF-kappaB; (ii) sphingomyelin hydrolysis to ceramide does not mediate all the effects of IL-1 beta, although it may play important roles in IL-1 beta signal transduction in human umbilical vein endothelial cells.	Sphingomyelins	48-61	interleukin 1 beta	Homo sapiens	319-328
8783796-0	1996	Antisense phosphorothioate oligonucleotide inhibits interleukin 1 beta production in the human macrophage-like cell line, U937.	Phosphorothioate Oligonucleotides	10-42	interleukin 1 beta	Homo sapiens	52-70
8783796-1	1996	To find more efficacious therapeutic possibilities for treatment of inflammatory disease, we studied the effects of antisense oligonucleotides on interleukin 1 beta (IL-1 beta) production of the human macrophage-like U937 cells.	Oligonucleotides	126-142	interleukin 1 beta	Homo sapiens	146-164
8783796-1	1996	To find more efficacious therapeutic possibilities for treatment of inflammatory disease, we studied the effects of antisense oligonucleotides on interleukin 1 beta (IL-1 beta) production of the human macrophage-like U937 cells.	Oligonucleotides	126-142	interleukin 1 beta	Homo sapiens	166-175
8783796-4	1996	An antisense phosphorothioate oligonucleotide (S-oligo), complementary to the sequence, including initiation codon of the IL-1 beta gene, inhibited IL-1 beta production in a dose-dependent and sequence-specific manner.	Phosphorothioate Oligonucleotides	13-45	interleukin 1 beta	Homo sapiens	122-131
8783796-4	1996	An antisense phosphorothioate oligonucleotide (S-oligo), complementary to the sequence, including initiation codon of the IL-1 beta gene, inhibited IL-1 beta production in a dose-dependent and sequence-specific manner.	Phosphorothioate Oligonucleotides	13-45	interleukin 1 beta	Homo sapiens	148-157
8783796-4	1996	An antisense phosphorothioate oligonucleotide (S-oligo), complementary to the sequence, including initiation codon of the IL-1 beta gene, inhibited IL-1 beta production in a dose-dependent and sequence-specific manner.	Oligonucleotides	47-54	interleukin 1 beta	Homo sapiens	122-131
8783796-4	1996	An antisense phosphorothioate oligonucleotide (S-oligo), complementary to the sequence, including initiation codon of the IL-1 beta gene, inhibited IL-1 beta production in a dose-dependent and sequence-specific manner.	Oligonucleotides	47-54	interleukin 1 beta	Homo sapiens	148-157
8612684-5	1996	Phorbol ester (PMA), a PKC activator, induced stromelysin gene expression, an effect enhanced by the addition of IL-1 beta.	Phorbol Esters	0-13	interleukin 1 beta	Homo sapiens	113-122
8612684-5	1996	Phorbol ester (PMA), a PKC activator, induced stromelysin gene expression, an effect enhanced by the addition of IL-1 beta.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 beta	Homo sapiens	113-122
8619479-0	1996	Nitric oxide production by the rat insulinoma cell line, RINm5F, Is specific for IL-1: a spectrophotometric IL-1 bioassay.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	81-85
8619479-0	1996	Nitric oxide production by the rat insulinoma cell line, RINm5F, Is specific for IL-1: a spectrophotometric IL-1 bioassay.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	108-112
8619479-2	1996	We have found that the rat insulinoma cell line, RINm5F, responds specifically and linearly to murine and human interleukin-1beta (IL-1beta) and IL-1alpha in the range of 0.1 to 1 unit/ml to produce nitric oxide.	Nitric Oxide	199-211	interleukin 1 beta	Homo sapiens	112-129
8619479-2	1996	We have found that the rat insulinoma cell line, RINm5F, responds specifically and linearly to murine and human interleukin-1beta (IL-1beta) and IL-1alpha in the range of 0.1 to 1 unit/ml to produce nitric oxide.	Nitric Oxide	199-211	interleukin 1 beta	Homo sapiens	131-139
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	Genistein	114-123	interleukin 1 beta	Homo sapiens	87-96
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	pyrrolidine dithiocarbamic acid	125-152	interleukin 1 beta	Homo sapiens	87-96
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	Dexamethasone	157-170	interleukin 1 beta	Homo sapiens	87-96
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	Egtazic Acid	207-277	interleukin 1 beta	Homo sapiens	87-96
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	Isoflavones	356-366	interleukin 1 beta	Homo sapiens	87-96
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	daidzein	367-375	interleukin 1 beta	Homo sapiens	87-96
8613710-6	1996	Kinetic studies with the RNA synthesis inhibitor, actinomycin D, showed that GM-CSF induces stable IL-1B mRNA.	Dactinomycin	50-63	interleukin 1 beta	Homo sapiens	99-104
8793554-4	1996	IL-1 beta synthesis was (pg/10(6) cells): MGmin-HSA 484.5 +/- 50.3; AGE-HSA 30.6 +/- 2.0 (n = 3).	Altretamine	48-51	interleukin 1 beta	Homo sapiens	0-9
8627304-3	1996	Both protein kinase C and reactive oxygen intermediates (ROIs) were involved in IL-6 and TNF alpha gene expression by IL-1 beta.	reactive oxygen	26-41	interleukin 1 beta	Homo sapiens	118-127
8609175-7	1996	When a mechanical stress was applied to H18/7-coated ferromagnetic beads bound to the surface of IL-1 beta-activated HUVEC, using a magnetical twisting cytometer, the observed resistance to the applied stress was inhibited by cytochalasin D, thus demonstrating transmembrane cytoskeletal mechanical linkage.	Cytochalasin D	226-240	interleukin 1 beta	Homo sapiens	97-106
8613710-7	1996	Cycloheximide enhanced the IL-1 beta mRNA accumulation by GM-CSF at the level of mRNA stabilization, but blocked IL-1 beta mRNA expression by TNF.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	27-36
8613710-7	1996	Cycloheximide enhanced the IL-1 beta mRNA accumulation by GM-CSF at the level of mRNA stabilization, but blocked IL-1 beta mRNA expression by TNF.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	113-122
8613948-6	1996	Budesonide (10(-7) M) dramatically reduced A-PBM proliferation (measured by 3H-thymidine incorporation) and cytokine (IL-1beta, IL-2, IL-6, IFN-gamma, TNF-alpha) production, but was not cytotoxic to immune cells.	Budesonide	0-10	interleukin 1 beta	Homo sapiens	118-126
8608158-1	1996	The effects of interleukin 1beta (IL1) in the range of concentration of 10-30 ng/ml on cholesterol metabolism were investigated in the monocyte-macrophage cell line J774.	Cholesterol	87-98	interleukin 1 beta	Homo sapiens	15-32
8606506-9	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta and the G PLC-receptor pathway is particularly regulated by physiologically relevant periods of hypoxia/reoxygenation.	Oxygen	17-23	interleukin 1 beta	Homo sapiens	123-132
8608158-1	1996	The effects of interleukin 1beta (IL1) in the range of concentration of 10-30 ng/ml on cholesterol metabolism were investigated in the monocyte-macrophage cell line J774.	Cholesterol	87-98	interleukin 1 beta	Homo sapiens	34-37
8608158-2	1996	IL1 enhanced cholesterol esterification by [14C]oleic acid and acyl-coenzyme A cholesterol acyl transferase activity in a dose-dependent manner.	Cholesterol	13-24	interleukin 1 beta	Homo sapiens	0-3
8608158-2	1996	IL1 enhanced cholesterol esterification by [14C]oleic acid and acyl-coenzyme A cholesterol acyl transferase activity in a dose-dependent manner.	[14c]oleic acid	43-58	interleukin 1 beta	Homo sapiens	0-3
8608158-3	1996	Incubation of IL1-treated cells with acetylated low density lipoproteins labelled with [3H]cholesteryllinoleate resulted in accumulation of radioactive cholesterol in free and esterified form.	[3h]cholesteryllinoleate	87-111	interleukin 1 beta	Homo sapiens	14-17
8608158-3	1996	Incubation of IL1-treated cells with acetylated low density lipoproteins labelled with [3H]cholesteryllinoleate resulted in accumulation of radioactive cholesterol in free and esterified form.	Cholesterol	152-163	interleukin 1 beta	Homo sapiens	14-17
8608158-4	1996	Concomitantly, IL1 increased the free and esterified cholesterol intracellular content measured by the cholesterol oxidase technique.	Cholesterol	53-64	interleukin 1 beta	Homo sapiens	15-18
8608158-5	1996	The effect of IL1 on cholesterol esterification by oleic acid was not observed in the presence of cycloheximide or of the ACAT inhibitor Sandoz 58 035.	Cholesterol	21-32	interleukin 1 beta	Homo sapiens	14-17
11091549-4	1996	A correlation was found between the degree of s-Le&amp;supx; expression and the attachment of cancer cells to human umbilical vein endothelial cells (HUVECs) activated by IL-1beta.	Adenosine Monophosphate	51-54	interleukin 1 beta	Homo sapiens	171-179
8608158-5	1996	The effect of IL1 on cholesterol esterification by oleic acid was not observed in the presence of cycloheximide or of the ACAT inhibitor Sandoz 58 035.	Oleic Acid	51-61	interleukin 1 beta	Homo sapiens	14-17
8607793-6	1996	We present a novel hypothesis whereby the effects of IL-1beta are not only due to activation of enzymes necessary for generation of eicosanoids but also to an inhibition of mechanisms that regulate the supply of arachidonic acid.	Eicosanoids	132-143	interleukin 1 beta	Homo sapiens	53-61
8608158-6	1996	IL1 also stimulated cholesterol esterification in other cell types such as human fibroblasts and murine endothelial and smooth muscle cells.	Cholesterol	20-31	interleukin 1 beta	Homo sapiens	0-3
8607793-6	1996	We present a novel hypothesis whereby the effects of IL-1beta are not only due to activation of enzymes necessary for generation of eicosanoids but also to an inhibition of mechanisms that regulate the supply of arachidonic acid.	Arachidonic Acid	212-228	interleukin 1 beta	Homo sapiens	53-61
8608158-7	1996	The effect of IL1 is specific, since IL2 or tumor necrosis factor (TNF) exhibited no significant activity, whereas oncostatin M only slightly enhanced cholesterol esterification.	Cholesterol	151-162	interleukin 1 beta	Homo sapiens	14-17
8608158-8	1996	Since cholesterol deposition is involved in the initiation and progression of the atherosclerotic lesions, these findings highlight the role of the inflammatory cytokine IL1 on this process.	Cholesterol	6-17	interleukin 1 beta	Homo sapiens	170-173
8602881-1	1996	Experiments were performed to examine the mechanism by which specific hemostatic proteins regulate the release of nitric oxide (NO) from interleukin-1 beta (IL-1beta) stimulated cultured rate aortic smooth muscle cells.	Nitric Oxide	114-126	interleukin 1 beta	Homo sapiens	137-155
8605994-0	1996	A benzothiophene-carboxamide is a potent inhibitor of IL-1beta induced VCAM-1 gene expression in human endothelial cells.	benzothiophene-carboxamide	2-28	interleukin 1 beta	Homo sapiens	54-62
8602881-1	1996	Experiments were performed to examine the mechanism by which specific hemostatic proteins regulate the release of nitric oxide (NO) from interleukin-1 beta (IL-1beta) stimulated cultured rate aortic smooth muscle cells.	Nitric Oxide	114-126	interleukin 1 beta	Homo sapiens	157-165
8602881-4	1996	However, only actinomycin D inhibited IL-1beta-stimulated iNOS mRNA expression, Treatment of smooth muscle cells with IL-1beta in the presence of platelet derived growth factor or thrombin resulted in the inhibition of cytokine-stimulated expression of iNOS mRNA and NO release.	Dactinomycin	14-27	interleukin 1 beta	Homo sapiens	38-46
8602881-4	1996	However, only actinomycin D inhibited IL-1beta-stimulated iNOS mRNA expression, Treatment of smooth muscle cells with IL-1beta in the presence of platelet derived growth factor or thrombin resulted in the inhibition of cytokine-stimulated expression of iNOS mRNA and NO release.	Dactinomycin	14-27	interleukin 1 beta	Homo sapiens	118-126
8605994-4	1996	BZT blocked the IL-1 beta induced cell surface expression of VCAM-1 in human endothelial cells but did not prevent nuclear translocation of NF-kappa B.	bzt	0-3	interleukin 1 beta	Homo sapiens	16-25
8602840-7	1996	A549 cells treated with IL-1beta (0.01 to 10 ng/ml) contained COX-2 protein and released greater amounts of PGE2.	Dinoprostone	108-112	interleukin 1 beta	Homo sapiens	24-32
8709978-5	1996	Induction of Egr-1 mRNA by IL-1 beta and TNF-alpha was completely inhibited by H-7 suggesting the mediation of protein kinase C. The induction by IL-1 beta and TNF-alpha of Egr-1 mRNA was independent of de novo protein synthesis since this induction was also observed in the presence of protein synthesis inhibitor cycloheximide.	Cycloheximide	315-328	interleukin 1 beta	Homo sapiens	146-155
8604711-3	1996	In addition, interleukin-1-beta-induced interleukin-6 production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L.	Calcium	142-149	interleukin 1 beta	Homo sapiens	13-31
8602840-8	1996	The increased COX-2 protein and activity in response to IL-1beta (10 ng/ml) was inhibited by the tyrosine kinase inhibitors tyrphostin (AG126; 0.015 to 15 microM) or erbstatin (0.004 to 4 microM).	Tyrphostins	124-134	interleukin 1 beta	Homo sapiens	56-64
8602840-8	1996	The increased COX-2 protein and activity in response to IL-1beta (10 ng/ml) was inhibited by the tyrosine kinase inhibitors tyrphostin (AG126; 0.015 to 15 microM) or erbstatin (0.004 to 4 microM).	AG 127	136-141	interleukin 1 beta	Homo sapiens	56-64
8602840-8	1996	The increased COX-2 protein and activity in response to IL-1beta (10 ng/ml) was inhibited by the tyrosine kinase inhibitors tyrphostin (AG126; 0.015 to 15 microM) or erbstatin (0.004 to 4 microM).	erbstatin	166-175	interleukin 1 beta	Homo sapiens	56-64
8735570-5	1996	Male lizards were injected with human IL-1 beta (10 ng/g animal), saline, or nothing (control) and the activity level (proportion of lizards above ground) was monitored for 48 h. IL-1 beta-injected lizards showed a decrease in activity compared to saline-injected and control lizards within 2 h after treatment.	Sodium Chloride	66-72	interleukin 1 beta	Homo sapiens	179-188
8638967-8	1996	A 30-min exposure to sulfur dioxide induced a significant decrease in spontaneous and lipopolysaccharide-stimulated tumor necrosis factor-alpha (p &lt; .001) and lipopolysaccharide-stimulated interleukin-1beta release (p &lt; .05).	Sulfur Dioxide	21-35	interleukin 1 beta	Homo sapiens	192-209
8638967-10	1996	Our results demonstrated a functional impairment of alveolar macrophages after sulfur dioxide exposure (i.e., release of tumor necrosis factor-alpha and interleukin-1beta).	Sulfur Dioxide	79-93	interleukin 1 beta	Homo sapiens	153-170
8833198-3	1996	Primary human astrocytes produced substantial amounts of NO in response to interleukin (IL)-1 alpha or IL-1 beta, which was blocked by the NO synthase inhibitor NG-mono-methyl-L-arginine (NMMA).	omega-N-Methylarginine	161-186	interleukin 1 beta	Homo sapiens	103-112
8833198-3	1996	Primary human astrocytes produced substantial amounts of NO in response to interleukin (IL)-1 alpha or IL-1 beta, which was blocked by the NO synthase inhibitor NG-mono-methyl-L-arginine (NMMA).	omega-N-Methylarginine	188-192	interleukin 1 beta	Homo sapiens	103-112
8641787-7	1996	Furthermore, tetracycline was found to inhibit LPS-induced TNF-alpha and IL-1 beta secretion, but not cytokine mRNA accumulation, in human monocytes in vitro.	Tetracycline	13-25	interleukin 1 beta	Homo sapiens	73-82
8604023-0	1996	IL-1 beta primes IL-8-activated human neutrophils for elastase release, phospholipase D activity, and calcium flux.	Calcium	102-109	interleukin 1 beta	Homo sapiens	0-9
8845176-4	1996	Interleukin (IL)-1beta also induced concentration-dependent sTNF-RI shedding from NCI-H292 cells, which could be inhibited by the PKC inhibitor calphostin C.	calphostin C	144-156	interleukin 1 beta	Homo sapiens	0-22
8845176-6	1996	Dexamethasone inhibited constitutive, as well as PMA- and IL-1beta-mediated sTNF-RI release from NCI-H292 cells in a concentration-dependent fashion.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	58-66
8845178-0	1996	Alveolar macrophages autoregulate IL-1 and IL-6 production by endogenous nitric oxide.	Nitric Oxide	73-85	interleukin 1 beta	Homo sapiens	34-38
8845178-3	1996	Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages.	Nitric Oxide	18-30	interleukin 1 beta	Homo sapiens	131-141
8845178-3	1996	Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages.	Arginine	49-59	interleukin 1 beta	Homo sapiens	131-141
8845178-3	1996	Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages.	omega-N-Methylarginine	69-95	interleukin 1 beta	Homo sapiens	131-141
8845178-3	1996	Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages.	omega-N-Methylarginine	97-101	interleukin 1 beta	Homo sapiens	131-141
8845178-5	1996	Conversely the nitric oxide donor S-nitroso-N-acetyl-D, L-penicillamine (SNAP) induced dose-dependent inhibition of IL-1 production in LPS-stimulated alveolar macrophages in which endogenous nitric oxide production was blocked.	Nitric Oxide	15-27	interleukin 1 beta	Homo sapiens	116-120
8845178-5	1996	Conversely the nitric oxide donor S-nitroso-N-acetyl-D, L-penicillamine (SNAP) induced dose-dependent inhibition of IL-1 production in LPS-stimulated alveolar macrophages in which endogenous nitric oxide production was blocked.	s-nitroso-n-acetyl-d, l-penicillamine	34-71	interleukin 1 beta	Homo sapiens	116-120
8845178-5	1996	Conversely the nitric oxide donor S-nitroso-N-acetyl-D, L-penicillamine (SNAP) induced dose-dependent inhibition of IL-1 production in LPS-stimulated alveolar macrophages in which endogenous nitric oxide production was blocked.	snap	73-77	interleukin 1 beta	Homo sapiens	116-120
8845178-6	1996	The results indicate that nitric oxide can affect the LPS-induced IL-1beta and IL-6 secretion by alveolar macrophages in an autoregulatory way and are discussed in view of the important physiologic consequences this autoregulation by nitric acid oxide may have.	Nitric Oxide	26-38	interleukin 1 beta	Homo sapiens	66-74
8634411-2	1996	We found that reactive oxygen intermediates (ROI) inhibit interleukin-1beta (IL-1beta) binding on human myelomonocytes.	reactive oxygen intermediates	14-43	interleukin 1 beta	Homo sapiens	58-75
8634411-2	1996	We found that reactive oxygen intermediates (ROI) inhibit interleukin-1beta (IL-1beta) binding on human myelomonocytes.	reactive oxygen intermediates	14-43	interleukin 1 beta	Homo sapiens	77-85
8634411-3	1996	Production of superoxide anion (O2-) by Xanthine (X) and Xanthine-Oxidase (XO) or NADPH caused a reduction (48% +/- 15% in 25 experiments) in the IL-1beta binding of polymorphonuclear cells (PMN) and monocytes that was inhibited by superoxide dismutase (SOD).	Superoxides	14-30	interleukin 1 beta	Homo sapiens	146-154
8634411-3	1996	Production of superoxide anion (O2-) by Xanthine (X) and Xanthine-Oxidase (XO) or NADPH caused a reduction (48% +/- 15% in 25 experiments) in the IL-1beta binding of polymorphonuclear cells (PMN) and monocytes that was inhibited by superoxide dismutase (SOD).	Superoxides	32-34	interleukin 1 beta	Homo sapiens	146-154
8634411-3	1996	Production of superoxide anion (O2-) by Xanthine (X) and Xanthine-Oxidase (XO) or NADPH caused a reduction (48% +/- 15% in 25 experiments) in the IL-1beta binding of polymorphonuclear cells (PMN) and monocytes that was inhibited by superoxide dismutase (SOD).	Xanthine	40-48	interleukin 1 beta	Homo sapiens	146-154
8634411-3	1996	Production of superoxide anion (O2-) by Xanthine (X) and Xanthine-Oxidase (XO) or NADPH caused a reduction (48% +/- 15% in 25 experiments) in the IL-1beta binding of polymorphonuclear cells (PMN) and monocytes that was inhibited by superoxide dismutase (SOD).	NADP	82-87	interleukin 1 beta	Homo sapiens	146-154
8608647-12	1996	Our results suggest that the relative amounts of IL-1beta and IL-1Ra or IL-8 may contribute, at least in part, to the neutrophil-mediated chronic airway inflammation in patients with chronic airway disease, and long-term erythromycin therapy may down-regulate the vigorous cycle between the cytokine network and neutrophil accumulation, with resultant reduction of neutrophil-mediated inflammatory response.	Erythromycin	221-233	interleukin 1 beta	Homo sapiens	49-57
8743284-2	1996	and intracerebroventricular (i.c.v) administration of increasing doses of recombinant human IL-1 beta, TNF alpha and IL-6 on plasma corticosterone (B) levels in rats.	Corticosterone	132-146	interleukin 1 beta	Homo sapiens	92-101
8796776-6	1996	The results revealed that cultured myometrial cells produced prostaglandins in response to IL-1 beta, TNF-alpha, EGF, PMA, and ionomycin at all gestational ages tested at a significantly increased rate (P &lt; 0.05 vs controls at and above 10 ng/ml of IL-1 beta, TNF alpha, and EGF; 1 microM for PMA, and 5 microM for ionomycin).	Prostaglandins	61-75	interleukin 1 beta	Homo sapiens	91-100
8882428-1	1996	Sixty-five natural flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1 beta in vitro.	Flavonoids	19-29	interleukin 1 beta	Homo sapiens	183-201
8735570-5	1996	Male lizards were injected with human IL-1 beta (10 ng/g animal), saline, or nothing (control) and the activity level (proportion of lizards above ground) was monitored for 48 h. IL-1 beta-injected lizards showed a decrease in activity compared to saline-injected and control lizards within 2 h after treatment.	Sodium Chloride	248-254	interleukin 1 beta	Homo sapiens	179-188
8882428-2	1996	Eighteen of these compounds inhibited the interleukin-1 beta-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.	Biflavonoids	152-163	interleukin 1 beta	Homo sapiens	42-60
8882428-2	1996	Eighteen of these compounds inhibited the interleukin-1 beta-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.	hinokiflavone	165-178	interleukin 1 beta	Homo sapiens	42-60
8617266-7	1996	However, despite the close similarity between TY and ICE active sites, TY fails to process the interleukin-1 beta precursor.	Thr-Tyr	71-73	interleukin 1 beta	Homo sapiens	95-113
8832976-0	1996	Suppression of human synovial fibroblast 85 kDa phospholipase A2 by antisense reduces interleukin-1 beta induced prostaglandin E2.	Dinoprostone	113-129	interleukin 1 beta	Homo sapiens	86-104
8832976-1	1996	OBJECTIVE: To evaluate the relative roles of rheumatoid synovial fibroblast phospholipases A2 (PLA2) in interleukin- 1beta (IL-1 beta) stimulated prostaglandin E2 (PGE2) production.	Dinoprostone	146-162	interleukin 1 beta	Homo sapiens	104-122
8832976-1	1996	OBJECTIVE: To evaluate the relative roles of rheumatoid synovial fibroblast phospholipases A2 (PLA2) in interleukin- 1beta (IL-1 beta) stimulated prostaglandin E2 (PGE2) production.	Dinoprostone	146-162	interleukin 1 beta	Homo sapiens	124-133
8832976-1	1996	OBJECTIVE: To evaluate the relative roles of rheumatoid synovial fibroblast phospholipases A2 (PLA2) in interleukin- 1beta (IL-1 beta) stimulated prostaglandin E2 (PGE2) production.	Dinoprostone	164-168	interleukin 1 beta	Homo sapiens	104-122
8832976-1	1996	OBJECTIVE: To evaluate the relative roles of rheumatoid synovial fibroblast phospholipases A2 (PLA2) in interleukin- 1beta (IL-1 beta) stimulated prostaglandin E2 (PGE2) production.	Dinoprostone	164-168	interleukin 1 beta	Homo sapiens	124-133
8832976-2	1996	METHODS: The role of the cytosolic 85 kDa PLA2 in IL-1beta induced human rheumatoid synovial fibroblast PGE2 formation was directly evaluated using an antisense phosphorothioate oligonucleotide to the initiation site of the 85 kDa PLA2 mRNA.	Dinoprostone	104-108	interleukin 1 beta	Homo sapiens	50-58
8832976-2	1996	METHODS: The role of the cytosolic 85 kDa PLA2 in IL-1beta induced human rheumatoid synovial fibroblast PGE2 formation was directly evaluated using an antisense phosphorothioate oligonucleotide to the initiation site of the 85 kDa PLA2 mRNA.	Phosphorothioate Oligonucleotides	161-193	interleukin 1 beta	Homo sapiens	50-58
8832976-8	1996	CONCLUSION: These data directly support a role for the 85 kDa PLA2, but not the 14 kDa PLA2, in IL- 1beta stimulated PGE2 production from human rheumatoid synovial fibroblast.	Dinoprostone	117-121	interleukin 1 beta	Homo sapiens	96-105
8600023-1	1996	Certain mammalian growth modulators, such as tumor necrosis factor alpha, interleukin-1beta, and gamma-interferon, induce an antiproliferative response-terminal differentiation, apoptosis, or cell cycle arrest-through a novel signal transduction pathway mediated by the lipid ceramide as a second messenger.	Ceramides	276-284	interleukin 1 beta	Homo sapiens	74-91
8721129-0	1996	[Effect of sevoflurane on release of TNF-alpha and IL-1 beta from human monocytes].	Sevoflurane	11-22	interleukin 1 beta	Homo sapiens	51-60
8721129-1	1996	Although isoflurane inhibits TNF-alpha and IL-1 beta release from human monocytes stimulated by LPS in dose dependent fashion, it is unclear whether sevoflurane has the same effects.	Isoflurane	9-19	interleukin 1 beta	Homo sapiens	43-52
8721129-2	1996	Therefore, we investigated whether sevoflurane could inhibit TNF-alpha and IL-1 beta secretions from human monocytes stimulated by LPS in dose dependent fashion in vitro.	Sevoflurane	35-46	interleukin 1 beta	Homo sapiens	75-84
8726465-9	1996	Although interleukin 1 beta drove expression of the human inducible nitric oxide synthase reporter, actual expression of nitric oxide required both interleukin 1 beta and interferon-gamma.	Nitric Oxide	68-80	interleukin 1 beta	Homo sapiens	9-27
8623807-6	1996	RESULTS: Cultured human myometrial cells from patients with and without prior intrauterine infection produced prostaglandins in response to interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor at a significantly increased rate (p&lt;0.05 vs controls at and above 10 ng/ml of interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor).	Prostaglandins	110-124	interleukin 1 beta	Homo sapiens	140-187
8623807-6	1996	RESULTS: Cultured human myometrial cells from patients with and without prior intrauterine infection produced prostaglandins in response to interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor at a significantly increased rate (p&lt;0.05 vs controls at and above 10 ng/ml of interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor).	Prostaglandins	110-124	interleukin 1 beta	Homo sapiens	299-346
8630267-4	1996	Because PGE2 is reported to inhibit interleukin 1 (IL-1) and tumor necrosis factor (TNF), it is likely that hypoxia, through changes in PGE2, will alter IL-1 and TNF release from the human alveolar macrophage.	Dinoprostone	8-12	interleukin 1 beta	Homo sapiens	51-55
8630267-16	1996	Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF.	Dinoprostone	8-12	interleukin 1 beta	Homo sapiens	54-58
8630267-4	1996	Because PGE2 is reported to inhibit interleukin 1 (IL-1) and tumor necrosis factor (TNF), it is likely that hypoxia, through changes in PGE2, will alter IL-1 and TNF release from the human alveolar macrophage.	Dinoprostone	8-12	interleukin 1 beta	Homo sapiens	153-157
8630267-16	1996	Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF.	Dinoprostone	8-12	interleukin 1 beta	Homo sapiens	54-66
8630267-16	1996	Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF.	Dinoprostone	87-91	interleukin 1 beta	Homo sapiens	54-58
8630267-4	1996	Because PGE2 is reported to inhibit interleukin 1 (IL-1) and tumor necrosis factor (TNF), it is likely that hypoxia, through changes in PGE2, will alter IL-1 and TNF release from the human alveolar macrophage.	Dinoprostone	136-140	interleukin 1 beta	Homo sapiens	51-55
8630267-16	1996	Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF.	Dinoprostone	87-91	interleukin 1 beta	Homo sapiens	54-66
8630267-4	1996	Because PGE2 is reported to inhibit interleukin 1 (IL-1) and tumor necrosis factor (TNF), it is likely that hypoxia, through changes in PGE2, will alter IL-1 and TNF release from the human alveolar macrophage.	Dinoprostone	136-140	interleukin 1 beta	Homo sapiens	153-157
8630267-16	1996	Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF.	Indomethacin	107-119	interleukin 1 beta	Homo sapiens	54-58
8630267-16	1996	Because PGE2 is reported to inhibit the expression of IL-1 and TNF genes, we inhibited PGE2 synthesis with indomethacin during culture in room air; the result was an increase in the release of IL-1 and TNF.	Indomethacin	107-119	interleukin 1 beta	Homo sapiens	54-66
8653494-3	1996	The stimulatory effect of TNF alpha on IL-1 beta production was accompanied by enhanced PGE2 formation.	Dinoprostone	88-92	interleukin 1 beta	Homo sapiens	39-48
8777274-3	1996	The release of IL-1 beta, IL-6 and TNF-alpha was correlated with total cholesterol at medium doses of LPS (100 ng/ml), and inversely correlated with lipopolysaccharide-binding protein (LBP) at low doses of LPS (1 ng/ml).	Cholesterol	71-82	interleukin 1 beta	Homo sapiens	15-24
8777276-2	1996	IL-1 alpha, IL-1 beta, TNF-alpha and TNF-beta caused a time- and concentration-dependent enhancement of prostaglandin E2 (PGE2) formation in the fibroblasts.	Dinoprostone	104-120	interleukin 1 beta	Homo sapiens	12-21
8777276-2	1996	IL-1 alpha, IL-1 beta, TNF-alpha and TNF-beta caused a time- and concentration-dependent enhancement of prostaglandin E2 (PGE2) formation in the fibroblasts.	Dinoprostone	122-126	interleukin 1 beta	Homo sapiens	12-21
8777276-4	1996	BK (1 microM) and thrombin (3 U/ml) synergistically potentiated IL-1 alpha and IL-1 beta stimulated PGE2 formation in 24 h cultures.	Dinoprostone	100-104	interleukin 1 beta	Homo sapiens	79-88
8777276-5	1996	The effect of BK and thrombin on IL-1 beta enhanced PGE2 formation was seen both at suboptimal and optimal concentrations of IL-1 beta without affecting the sensitivity to IL-1 beta.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	33-42
8777276-5	1996	The effect of BK and thrombin on IL-1 beta enhanced PGE2 formation was seen both at suboptimal and optimal concentrations of IL-1 beta without affecting the sensitivity to IL-1 beta.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	125-134
8777276-5	1996	The effect of BK and thrombin on IL-1 beta enhanced PGE2 formation was seen both at suboptimal and optimal concentrations of IL-1 beta without affecting the sensitivity to IL-1 beta.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	125-134
8777276-10	1996	Preincubation with IL-1 beta and TNF-alpha for 24 h resulted in a substantial amplification of the PGE2 response to a subsequent 24 h challenge with BK in the absence of cytokine.	Dinoprostone	99-103	interleukin 1 beta	Homo sapiens	19-28
8777276-11	1996	Similarly, when the pulp fibroblasts were preincubated with or without IL-1 beta or TNF-alpha for 24 h and then challenged with exogenous arachidonic acid for 60 min, PGE2 formation was significantly enhanced in cytokine pretreated cells.	Arachidonic Acid	138-154	interleukin 1 beta	Homo sapiens	71-80
8777276-11	1996	Similarly, when the pulp fibroblasts were preincubated with or without IL-1 beta or TNF-alpha for 24 h and then challenged with exogenous arachidonic acid for 60 min, PGE2 formation was significantly enhanced in cytokine pretreated cells.	Dinoprostone	167-171	interleukin 1 beta	Homo sapiens	71-80
8601429-5	1996	DCI also revealed a marked inhibitory effect in IL-1 beta-stimulated VSMC, but was less effective in cells treated with forskolin.	3,4-dichloroisocoumarin	0-3	interleukin 1 beta	Homo sapiens	48-57
8601429-6	1996	DCI, but not NAS, also suppressed the activation of NF-kappa B in VSMC exposed to IL-1 beta, while no significant NF-kappa B activation was detected in forskolin-treated cells.	3,4-dichloroisocoumarin	0-3	interleukin 1 beta	Homo sapiens	82-91
8777274-0	1996	LPS induced release of IL-1 beta, IL-6, IL-8 and TNF-alpha in EDTA or heparin anticoagulated whole blood from persons with high or low levels of serum HDL.	Edetic Acid	62-66	interleukin 1 beta	Homo sapiens	23-32
8653494-0	1996	Effect of phenytoin on interleukin-1 beta production in human gingival fibroblasts challenged to tumor necrosis factor alpha in vitro.	Phenytoin	10-19	interleukin 1 beta	Homo sapiens	23-41
8653494-1	1996	Effects and interaction of tumor necrosis factor alpha (TNF alpha) and the antiepileptic drug phenytoin (PHT) on interleukin-1 beta (IL-1 beta) production as well as on prostaglandin E2 (PGE2) formation were studied in gingival fibroblasts in vitro.	Phenytoin	105-108	interleukin 1 beta	Homo sapiens	113-131
8653494-1	1996	Effects and interaction of tumor necrosis factor alpha (TNF alpha) and the antiepileptic drug phenytoin (PHT) on interleukin-1 beta (IL-1 beta) production as well as on prostaglandin E2 (PGE2) formation were studied in gingival fibroblasts in vitro.	Phenytoin	105-108	interleukin 1 beta	Homo sapiens	133-142
8653494-6	1996	The production of IL-1 beta induced by TNF alpha and the combination of TNF alpha and PHT was further enhanced in the presence of the prostaglandin endoperoxide (PGH) synthase inhibitors, indomethacin and flurbiprofen.	Prostaglandin Endoperoxides	134-160	interleukin 1 beta	Homo sapiens	18-27
8653494-6	1996	The production of IL-1 beta induced by TNF alpha and the combination of TNF alpha and PHT was further enhanced in the presence of the prostaglandin endoperoxide (PGH) synthase inhibitors, indomethacin and flurbiprofen.	GH2 protein, human	162-165	interleukin 1 beta	Homo sapiens	18-27
8653494-6	1996	The production of IL-1 beta induced by TNF alpha and the combination of TNF alpha and PHT was further enhanced in the presence of the prostaglandin endoperoxide (PGH) synthase inhibitors, indomethacin and flurbiprofen.	Indomethacin	188-200	interleukin 1 beta	Homo sapiens	18-27
8653494-6	1996	The production of IL-1 beta induced by TNF alpha and the combination of TNF alpha and PHT was further enhanced in the presence of the prostaglandin endoperoxide (PGH) synthase inhibitors, indomethacin and flurbiprofen.	Flurbiprofen	205-217	interleukin 1 beta	Homo sapiens	18-27
8592146-1	1996	The death of dopaminergic and other neurons in primary cultures of the mesencephalon could be induced by treatment with ceramide, as in lymphocytes where it mediates activation by the cytokines tumor necrosis factor-alpha and interleukin-1 beta of a novel sphingomyelin-dependent signaling pathway leading to apoptosis.	Ceramides	120-128	interleukin 1 beta	Homo sapiens	226-244
8671241-6	1996	These cells are viable for at least 48 h in culture after the enrichment procedure, and produce prostaglandins after stimulation with interleukin-1 beta.	Prostaglandins	96-110	interleukin 1 beta	Homo sapiens	134-152
8785389-6	1996	The adherence of PMN to HPMC after stimulation with either IL-1 beta or TNF alpha was both dose- and time-dependent.	hydroxypropylmethylcellulose-lactose matrix	24-28	interleukin 1 beta	Homo sapiens	59-68
8785389-8	1996	After 12 h, the number of PMN binding to HPMC increased from 71.3 +/- 12.5 in control cells to 180 +/- 36.5 and 125 +/- 23.6 (x 10(3) PMN), after IL-1 beta (100 pg/mL) and TNF alpha (1000 pg/mL), respectively (z = 2.52 and 2.38, N = 6, P &lt; 0.02 versus control for both).	hydroxypropylmethylcellulose-lactose matrix	41-45	interleukin 1 beta	Homo sapiens	146-155
8711133-6	1996	In addition, cycloheximide (5 micrograms/ml) apparently superinduced, but actinomycin D (2 micrograms/ml) inhibited IL-1 beta-induced cPLA2 and PGHS-2 mRNA expression suggesting that both are immediate early genes and a transcriptional mechanism is involved in the induction of both cPLA2 and PGHS-2 mRNA by IL-1 beta.	Dactinomycin	74-87	interleukin 1 beta	Homo sapiens	116-125
8689276-2	1996	There also is increasing recognition of the role of calcium in the production of a variety of cytokines such as tumor necrosis factor alpha and interleukin-1 beta, which are important mediators of sepsis.	Calcium	52-59	interleukin 1 beta	Homo sapiens	144-162
8711133-0	1996	Induction of both cytosolic phospholipase A2 and prostaglandin H synthase-2 by interleukin-1 beta in WISH cells in inhibited by dexamethasone.	Dexamethasone	128-141	interleukin 1 beta	Homo sapiens	79-97
8711133-1	1996	In previous studies we have shown that IL-1 beta induced both PGE2 release and total cellular cPLA2 activity and cPLA2 protein synthesis in human amnion-derived WISH cells.	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	39-48
8708946-0	1996	Nicotine effects on PGE2 and IL-1 beta release by LPS-treated human monocytes.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	29-38
8708946-10	1996	IL-1 beta secretion was lower for either LPS plus 100 micrograms/ml nicotine relative to LPS alone, although not significantly.	Nicotine	68-76	interleukin 1 beta	Homo sapiens	0-9
8711133-4	1996	The synthetic glucocorticoid dexamethasone (10(-10)-10(-6)M) inhibited IL-1 beta-induced cPLA2 and PGHS-2 mRNA expression activity and protein synthesis and PGE2 release in a concentration dependent manner.	Dexamethasone	29-42	interleukin 1 beta	Homo sapiens	71-80
8837301-3	1996	Among patients who were taking combined therapy with lentinan, an increase in IL-1 beta production of more than 50% was found 8 weeks (2 months) after the initiation of therapy in 8 of 12 patients given 2 mg at 2-week intervals, and in 11 of 16 patients given the same dose at 4-week intervals.	Lentinan	53-61	interleukin 1 beta	Homo sapiens	78-87
8711133-4	1996	The synthetic glucocorticoid dexamethasone (10(-10)-10(-6)M) inhibited IL-1 beta-induced cPLA2 and PGHS-2 mRNA expression activity and protein synthesis and PGE2 release in a concentration dependent manner.	Dinoprostone	157-161	interleukin 1 beta	Homo sapiens	71-80
8669050-11	1996	CONCLUSION: N-acetylcysteine is capable to co-stimulate radioprotective cytokines like IL-1 alpha and IL-1 beta and to enhance IL-2 in vitro, whereas higher doses result in a suppression.	Acetylcysteine	12-28	interleukin 1 beta	Homo sapiens	102-111
8555483-10	1996	These data indicate that ATRA increases the promyelocyte-induced EC TF, partly through increased IL-1 beta production.	Tretinoin	25-29	interleukin 1 beta	Homo sapiens	97-106
8815590-0	1996	Echinomycin suppresses the pyrogenic effects of endotoxin and interleukin-1 beta in human endothelial cells and peripheral blood mononuclear cells.	Echinomycin	0-11	interleukin 1 beta	Homo sapiens	62-80
8815590-2	1996	Echinomycin, a cyclic octapeptide of microbial origin strongly inhibited LPS- and IL-1 beta-induced tissue factor expression in HUVEC and PBMC with IC50 values in the subnanomolar range at the same time it reduced LPS and IL-1 beta-induced expression of intercellular adhesion molecule-1 (ICAM-1, CD54) on HUVEC (IC50 = 0.4 +/- 0.1 and 0.3 +/- 0.2 nM respectively).	Echinomycin	0-11	interleukin 1 beta	Homo sapiens	82-91
8815590-2	1996	Echinomycin, a cyclic octapeptide of microbial origin strongly inhibited LPS- and IL-1 beta-induced tissue factor expression in HUVEC and PBMC with IC50 values in the subnanomolar range at the same time it reduced LPS and IL-1 beta-induced expression of intercellular adhesion molecule-1 (ICAM-1, CD54) on HUVEC (IC50 = 0.4 +/- 0.1 and 0.3 +/- 0.2 nM respectively).	Echinomycin	0-11	interleukin 1 beta	Homo sapiens	222-231
8815590-3	1996	Echinomycin also reduced LPS-induced secretion of IL-1 beta and IL-6 by human PBMC (IC50 = 10 +/- 2 and 3 +/- 0.5 nM respectively).	Echinomycin	0-11	interleukin 1 beta	Homo sapiens	50-59
8815590-4	1996	These observations demonstrate that echinomycin protects endothelial cells and PBMC from the pyrogenic effect of LPS and IL-1 beta.	Echinomycin	36-47	interleukin 1 beta	Homo sapiens	121-130
8561789-5	1996	We also demonstrate that IL-1 beta costimulation with a protein synthesis inhibitor, cycloheximide, or a transcription blocker, actinomycin D, results in superinduction of NF-kappa B but not the transcription factors Oct 1, AP-1, and Sp-1.	Cycloheximide	85-98	interleukin 1 beta	Homo sapiens	25-34
8561789-5	1996	We also demonstrate that IL-1 beta costimulation with a protein synthesis inhibitor, cycloheximide, or a transcription blocker, actinomycin D, results in superinduction of NF-kappa B but not the transcription factors Oct 1, AP-1, and Sp-1.	Dactinomycin	128-141	interleukin 1 beta	Homo sapiens	25-34
8573086-1	1996	We recently reported that cyclic AMP (cAMP) specifically inhibits lipopolysaccharide (LPS)-induced interleukin 1 beta (IL-1 beta) transcription initiation in astrocytic cells but enhances the LPS induction of IL-1 beta in monocytic cells.	Cyclic AMP	26-36	interleukin 1 beta	Homo sapiens	99-117
8573086-1	1996	We recently reported that cyclic AMP (cAMP) specifically inhibits lipopolysaccharide (LPS)-induced interleukin 1 beta (IL-1 beta) transcription initiation in astrocytic cells but enhances the LPS induction of IL-1 beta in monocytic cells.	Cyclic AMP	26-36	interleukin 1 beta	Homo sapiens	119-128
8573086-1	1996	We recently reported that cyclic AMP (cAMP) specifically inhibits lipopolysaccharide (LPS)-induced interleukin 1 beta (IL-1 beta) transcription initiation in astrocytic cells but enhances the LPS induction of IL-1 beta in monocytic cells.	Cyclic AMP	26-36	interleukin 1 beta	Homo sapiens	209-218
8573086-1	1996	We recently reported that cyclic AMP (cAMP) specifically inhibits lipopolysaccharide (LPS)-induced interleukin 1 beta (IL-1 beta) transcription initiation in astrocytic cells but enhances the LPS induction of IL-1 beta in monocytic cells.	Cyclic AMP	38-42	interleukin 1 beta	Homo sapiens	99-117
8573086-1	1996	We recently reported that cyclic AMP (cAMP) specifically inhibits lipopolysaccharide (LPS)-induced interleukin 1 beta (IL-1 beta) transcription initiation in astrocytic cells but enhances the LPS induction of IL-1 beta in monocytic cells.	Cyclic AMP	38-42	interleukin 1 beta	Homo sapiens	119-128
8573086-1	1996	We recently reported that cyclic AMP (cAMP) specifically inhibits lipopolysaccharide (LPS)-induced interleukin 1 beta (IL-1 beta) transcription initiation in astrocytic cells but enhances the LPS induction of IL-1 beta in monocytic cells.	Cyclic AMP	38-42	interleukin 1 beta	Homo sapiens	209-218
8573086-2	1996	The purpose of this study was to determine how cAMP differentially regulates LPS-induced IL-1 beta transcription in these two cell types.	Cyclic AMP	47-51	interleukin 1 beta	Homo sapiens	89-98
8573086-6	1996	These findings suggest that, in astrocytic cells, elevated intracellular cAMP levels may negatively regulate LPS activation of IL-1 beta via the MAP kinase signalling pathway.	Cyclic AMP	73-77	interleukin 1 beta	Homo sapiens	127-136
9244174-0	1996	Stimulation of prostaglandin E2 synthesis by interleukin-1beta is amplified by interferons but inhibited by interleukin-4 in human amnion-derived WISH cells.	Dinoprostone	15-31	interleukin 1 beta	Homo sapiens	45-62
8705396-4	1996	Changes in GPLD activation correlated best with changes in O2-production during the hypoxia to hypoxia/reoxygenation transition induced by TNF-alpha-Fn and IL-1 beta +/- Fn.	Oxygen	59-61	interleukin 1 beta	Homo sapiens	156-165
8705396-5	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta, and activation of the GPLD-pathway appears to be highly sensitive to hypoxia and hypoxia/reoxygenation.	Oxygen	17-23	interleukin 1 beta	Homo sapiens	123-132
9244174-2	1996	However, the cells were stimulated greatly to synthesize prostaglandin E2 by interleukin-1beta in a dose-dependent manner.	Dinoprostone	57-73	interleukin 1 beta	Homo sapiens	77-94
9244174-10	1996	These results indicate that regulation of interleukin-1beta-stimulated prostaglandin E2 synthesis by interferons and interleukin-4 is controlled at the m-RNA level of cyclooxygenase-2.	Dinoprostone	71-87	interleukin 1 beta	Homo sapiens	42-59
8865864-5	1996	MC were stimulated with increasing doses of IL-1 beta or tumor necrosis factor-alpha for 24 hours, after which the supernatant was analyzed for IL-8 content.	Methylcholanthrene	0-2	interleukin 1 beta	Homo sapiens	44-84
8790842-29	1996	This effect may be partly due to IL-1 stimulated secretion of PGE2.	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	33-37
8604658-1	1996	The effect of a flaxseed oil-based diet on tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta) synthesis was examined in healthy volunteers.	Linseed Oil	16-28	interleukin 1 beta	Homo sapiens	87-105
8615653-0	1996	Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21).	Tetradecanoylphorbol Acetate	56-59	interleukin 1 beta	Homo sapiens	28-32
8629860-4	1996	The results indicated that such cells respond to beryllium ions in the presence of fluoride by accumulation of messenger ribonucleic acid for both tumor necrosis factor alpha and interleukin-1 beta.	Beryllium	49-58	interleukin 1 beta	Homo sapiens	179-197
8718562-9	1996	After reuse with pyrogen-free BC-rinse and contaminated RUF no IL-1 beta synthesis was observed; however, when pyrogen-free BC-rinse and contaminated RUF was applied to new dialyzers, IL-1 beta synthesis averaged 1,620 +/- 1,200 pg/ml.	bc-rinse	124-132	interleukin 1 beta	Homo sapiens	184-193
8629860-4	1996	The results indicated that such cells respond to beryllium ions in the presence of fluoride by accumulation of messenger ribonucleic acid for both tumor necrosis factor alpha and interleukin-1 beta.	Fluorides	83-91	interleukin 1 beta	Homo sapiens	179-197
8785034-5	1996	Exogenous and endogenous prostaglandin E2 (PGE2) was found to inhibit the release of TNF alpha rather than IL-1 beta from peritoneal macrophages, indicating that the synthesis and secretion of these cytokines is distinctly regulated by PGE2.	Dinoprostone	25-41	interleukin 1 beta	Homo sapiens	107-116
8785034-5	1996	Exogenous and endogenous prostaglandin E2 (PGE2) was found to inhibit the release of TNF alpha rather than IL-1 beta from peritoneal macrophages, indicating that the synthesis and secretion of these cytokines is distinctly regulated by PGE2.	Dinoprostone	43-47	interleukin 1 beta	Homo sapiens	107-116
8787641-0	1996	Morphine affects the brain-immune axis by modulating an interleukin-1 beta dependent pathway.	Morphine	0-8	interleukin 1 beta	Homo sapiens	56-74
9166494-7	1996	hIL-1beta was measurable in three of three tumors from vMJ601hIL-1beta treated mice on postinjection day 3, one of three on day 6, and one of three on day 9; no hIL-1beta was detected in any other tumors or normal tissues.	1,2-Di(anthracen-9-yl)ethyne	4-9	interleukin 1 beta	Homo sapiens	61-70
8995502-5	1996	In addition R-verapamil inhibited the release of IL1beta and tumor necrosis factor alpha during allogeneic stimulation.	Verapamil	12-23	interleukin 1 beta	Homo sapiens	49-56
8924035-1	1996	Effects of recombinant human interleukin-1 beta (IL-1 beta) on the neuronal activities in the rat dorsal motor nucleus of the vagus (DMV) were investigated by extra- and intracellular recordings in slice preparations.	(2R,3R)-2,3-dihydroxy-3-methylpentanoic acid	133-136	interleukin 1 beta	Homo sapiens	49-58
8832951-4	1996	RESULTS: IL-1 beta failed to stimulate glycosaminoglycan synthesis in REM fibroblasts whereas it stimulated glycosaminoglycan synthesis up to 6-fold in control fibroblasts.	Glycosaminoglycans	108-125	interleukin 1 beta	Homo sapiens	9-18
8832951-6	1996	CONCLUSION: These results suggest that the patient fibroblasts exhibit an abnormal response to stimulation by exogenous IL-1 beta and that IL- 1 beta may be involved in the abnormal hyaluronic acid metabolism in REM syndrome.	Hyaluronic Acid	182-197	interleukin 1 beta	Homo sapiens	139-149
8906110-6	1996	In a further in vitro study, LX 0104 significantly suppressed the adhesion of human and guinea-pig eosinophils to human umbilical vein endothelial cells activated with interleukin-1 beta.	LX 0104	29-36	interleukin 1 beta	Homo sapiens	168-186
8536613-11	1996	Il-1 beta also stimulates PGE2 release, and this effect was inhibited by both NGF antibodies and a trk receptor blocker, NGF antibodies administered in vivo attenuated the increase in ovarian PGE2 synthesis that antedates ovulation.	Dinoprostone	26-30	interleukin 1 beta	Homo sapiens	0-9
8536785-7	1996	IL-1 alpha-induced GM-CSF, IL-1 beta, IL-6, IL-11, and LIF mRNA levels were reduced by the addition of dexamethasone, whereas dexamethasone had no influence on the amounts of IL-1 alpha-induced G-CSF mRNA.	Dexamethasone	103-116	interleukin 1 beta	Homo sapiens	27-36
8704095-2	1996	We examined paraffin sections for the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor-alpha, in 40 cases of Hodgkin"s disease.	Paraffin	12-20	interleukin 1 beta	Homo sapiens	73-123
8904180-2	1996	Dexamethasone, an inhibitor of cytokine production, inhibited LPS-induced tissue factor and IL-6 release by mononuclear cells (MNC), but enhanced IL-1beta-evoked tissue factor activity.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	146-154
9129241-1	1996	This study was designed to investigate whether interleukin (IL)-1 beta would stimulate nitric oxide (NO) production in cultured aortic vascular smooth muscle cells (VSMCs), and to determine the basic effect of the liberated NO on VSMC proliferation.	Nitric Oxide	87-99	interleukin 1 beta	Homo sapiens	47-70
9129241-3	1996	VSMCs were IL-1 beta-pretreated in insert cups, and co-cultured with untreated VSMC in the wells.	vsmc	0-4	interleukin 1 beta	Homo sapiens	11-20
9129241-7	1996	IL-1 beta-pretreated VSMCs significantly inhibited 3H-Tdr incorporation of the co-cultured VSMC.	vsmcs	21-26	interleukin 1 beta	Homo sapiens	0-9
9129241-7	1996	IL-1 beta-pretreated VSMCs significantly inhibited 3H-Tdr incorporation of the co-cultured VSMC.	Tritium	51-53	interleukin 1 beta	Homo sapiens	0-9
9129241-7	1996	IL-1 beta-pretreated VSMCs significantly inhibited 3H-Tdr incorporation of the co-cultured VSMC.	vsmc	21-25	interleukin 1 beta	Homo sapiens	0-9
9129241-9	1996	These results suggest that, in human VSMC, IL-1 beta stimulates NO production that is enhanced by intracellular cAMP accumulation, and that the liberated NO inhibits further VSMC proliferation in an autocrine fashion.	Cyclic AMP	112-116	interleukin 1 beta	Homo sapiens	43-52
9129241-9	1996	These results suggest that, in human VSMC, IL-1 beta stimulates NO production that is enhanced by intracellular cAMP accumulation, and that the liberated NO inhibits further VSMC proliferation in an autocrine fashion.	vsmc	37-41	interleukin 1 beta	Homo sapiens	43-52
8598489-0	1996	IL-1 beta does not cause neutrophil degranulation but does lead to IL-6, IL-8, and nitrite/nitrate release when used in patients with cancer.	Nitrites	83-90	interleukin 1 beta	Homo sapiens	0-9
8867766-7	1996	Dexamethasone (10(-7) M), known to inhibit inflammatory reactions and retard wound healing, also inhibited the induction of KGF mRNA expression by IL-1 alpha, IL-1 beta and TNF-alpha.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	159-168
8598489-9	1996	These results demonstrate that, unlike TNF, IL-1 does not cause neutrophil degranulation in man, despite its ability to cause neutrophilia and the rapid release of IL-6, IL-8, and nitrite/nitrate.	Nitrites	180-187	interleukin 1 beta	Homo sapiens	44-48
8867766-6	1996	The protein synthesis inhibitor cycloheximide abrogated the effects of IL-1 alpha, IL-1 beta and TNF-alpha on KGF gene induction, indicating that new protein synthesis is required in the process.	Cycloheximide	32-45	interleukin 1 beta	Homo sapiens	83-92
8598489-0	1996	IL-1 beta does not cause neutrophil degranulation but does lead to IL-6, IL-8, and nitrite/nitrate release when used in patients with cancer.	Nitrates	91-98	interleukin 1 beta	Homo sapiens	0-9
8649215-0	1996	Interleukin-1 beta specifically stimulates nitric oxide production in the hypothalamus.	Nitric Oxide	43-55	interleukin 1 beta	Homo sapiens	0-18
8838503-1	1996	OBJECTIVE: To compare the effects of tenidap, a new antirheumatic drug, with a nonsteroidal anti-inflammatory drug, naproxen, on the synthesis and expression of interleukin-1 beta (IL-1 beta), tumor necrosis factor (TNF-alpha), and interleukin-6 (IL-6) in rheumatoid synovium.	Naproxen	116-124	interleukin 1 beta	Homo sapiens	161-179
8838503-1	1996	OBJECTIVE: To compare the effects of tenidap, a new antirheumatic drug, with a nonsteroidal anti-inflammatory drug, naproxen, on the synthesis and expression of interleukin-1 beta (IL-1 beta), tumor necrosis factor (TNF-alpha), and interleukin-6 (IL-6) in rheumatoid synovium.	Naproxen	116-124	interleukin 1 beta	Homo sapiens	181-190
8838503-6	1996	Under LPS stimulation, IL-1 beta synthesis was inhibited by tenidap at all concentrations tested (p &lt; 0.01) and by naproxen at only 90 micrograms/ml (p &lt; 0.01).	Naproxen	118-126	interleukin 1 beta	Homo sapiens	23-32
8838503-12	1996	Naproxen only slightly reduced the LPS induced expression of IL-6, while enhancing the IL-1 beta expression.	Naproxen	0-8	interleukin 1 beta	Homo sapiens	87-96
8649215-1	1996	In previous experiments we have shown the role of nitric oxide (NO) in basal and interleukin-1 beta (IL-1 beta)-induced CRH and ACTH release in vitro.	Nitric Oxide	50-62	interleukin 1 beta	Homo sapiens	81-99
8649215-1	1996	In previous experiments we have shown the role of nitric oxide (NO) in basal and interleukin-1 beta (IL-1 beta)-induced CRH and ACTH release in vitro.	Nitric Oxide	50-62	interleukin 1 beta	Homo sapiens	101-110
8747002-0	1996	Modulation of IL-1 beta, IL-6, IL-8, TNF-alpha, and TGF-beta secretions by alveolar macrophages under NO2 exposure.	Nitrogen Dioxide	102-105	interleukin 1 beta	Homo sapiens	14-23
8747002-7	1996	Exposure for 30 min to NO2 induced a significant decrease of LPS-stimulated IL-1 Beta, IL-6, IL-8, and TNF-alpha (p &lt; .05).	Nitrogen Dioxide	23-26	interleukin 1 beta	Homo sapiens	76-85
8747002-10	1996	NO2 exposure of LPS-stimulated AM resulted in a functional impairment of AM after NO2 exposure regarding IL-1 beta, IL-6, IL-8, and TNF-alpha.	Nitrogen Dioxide	0-3	interleukin 1 beta	Homo sapiens	105-114
18475719-6	1996	This IL-1beta- and LPS-mediated increase in eicosanoids could be reduced by dexamethasone, but was not accompanied by an increase in lipocortin I or II expression.	Eicosanoids	44-55	interleukin 1 beta	Homo sapiens	5-13
18475751-5	1996	Both LPS and IL-1(beta) exposure were noted to stimulate cellular PGE(2) release, a response which was significantly inhibited by IL-1ra treatment.	Dinoprostone	66-72	interleukin 1 beta	Homo sapiens	13-23
18475719-6	1996	This IL-1beta- and LPS-mediated increase in eicosanoids could be reduced by dexamethasone, but was not accompanied by an increase in lipocortin I or II expression.	Dexamethasone	76-89	interleukin 1 beta	Homo sapiens	5-13
8747002-10	1996	NO2 exposure of LPS-stimulated AM resulted in a functional impairment of AM after NO2 exposure regarding IL-1 beta, IL-6, IL-8, and TNF-alpha.	Nitrogen Dioxide	82-85	interleukin 1 beta	Homo sapiens	105-114
8840306-0	1996	Comparison of effects of calcitriol and calcium carbonate on secretion of interleukin-1 beta and tumour necrosis factor-alpha by uraemic peripheral blood mononuclear cells.	Calcitriol	25-35	interleukin 1 beta	Homo sapiens	74-125
8883016-10	1996	When stimulated with LPS, IL-1 beta production by PMO from G-PDF exceeded that of PMO from AA-PDF (p &lt; 0.002).	g-pdf	59-64	interleukin 1 beta	Homo sapiens	26-35
8883016-14	1996	In addition, the higher release of IL-1 beta and IL-8 by PMO isolated from G-PDF suggests a stronger intra-abdominal activation of PMO, with G-PDF acting as a chemical inflammatory agent.	g-pdf	75-80	interleukin 1 beta	Homo sapiens	35-44
8869967-0	1996	The antiproliferative effect of trans-retinoic acid is associated with selective induction of interleukin-1 beta, a cytokine that directly inhibits growth of lung cancer cells.	Tretinoin	32-51	interleukin 1 beta	Homo sapiens	94-112
8869967-7	1996	Growth inhibition similar to that following RA treatment could be reproduced by exposing cells to exogeneous IL-1 beta alone.	Tretinoin	44-46	interleukin 1 beta	Homo sapiens	109-118
8910920-0	1996	Effect of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor-alpha on the intracellular fluorescein fluorescence polarization of human lung fibroblasts.	Fluorescein	103-114	interleukin 1 beta	Homo sapiens	31-81
8910920-6	1996	The reduction in IFFP, following stimulation with the cytokines, was detected as early as 20 min after exposure to the cytokines, lasted at least 40-60 min after exposure to IL-1 alpha and IL-1 beta, and was inhibited by vinblastine, an inhibitor of the polymerization of microtubules.	Vinblastine	221-232	interleukin 1 beta	Homo sapiens	189-198
8728164-0	1996	Interleukin-1 beta stimulates glucose uptake of human peritoneal mesothelial cells in vitro.	Glucose	30-37	interleukin 1 beta	Homo sapiens	0-18
8728164-7	1996	These data indicate a GU of HPMC, which is mediated by a glucose transporter and stimulated by IL-1 beta.	hydroxypropylmethylcellulose-lactose matrix	28-32	interleukin 1 beta	Homo sapiens	95-104
8984489-1	1996	The production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) by peripheral mononuclears induced by prodigiosane, tuberculin, phytohemagglutinin and unduced and the serum levels of the above cytokines were studied.	prodigiosane	131-143	interleukin 1 beta	Homo sapiens	62-80
8984489-1	1996	The production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) by peripheral mononuclears induced by prodigiosane, tuberculin, phytohemagglutinin and unduced and the serum levels of the above cytokines were studied.	prodigiosane	131-143	interleukin 1 beta	Homo sapiens	82-91
8840306-0	1996	Comparison of effects of calcitriol and calcium carbonate on secretion of interleukin-1 beta and tumour necrosis factor-alpha by uraemic peripheral blood mononuclear cells.	Calcium Carbonate	40-57	interleukin 1 beta	Homo sapiens	74-125
8840306-8	1996	These results suggest that supplementation with calcitriol is necessary to maintain bone formation and normalize IL-1 beta and TNF-alpha secretion by activated PBMC in uraemic patients.	Calcitriol	48-58	interleukin 1 beta	Homo sapiens	113-122
8519653-6	1995	Interleukin 1 beta (IL-1 beta) also induced PGE2 production in breast fibroblasts in the presence of excess substrate, consistent with cyclo-oxygenase induction by the cytokine.	Dinoprostone	44-48	interleukin 1 beta	Homo sapiens	0-18
8833992-0	1996	Interleukin 1 beta, tumor necrosis factor alpha, and interleukin 8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis: a potential mechanism of macrolide therapy.	Macrolides	167-176	interleukin 1 beta	Homo sapiens	0-47
8628978-1	1996	Inducible cyclooxygenase-2 (COX-2), but not constitutive COX-1, can be upregulated in rheumatoid synovial tissue by interleukin-1 beta and phorbol esters and is inhibited by dexamethasone.	Dexamethasone	174-187	interleukin 1 beta	Homo sapiens	116-134
8903852-7	1995	Treatment of brain cell cultures with IL-1beta plus TNF-alpha was found to inhibit [3H]-glutamate uptake and astrocyte glutamine synthetase activity, two major pathways involved in NMDA receptor-related neurotoxicity.	Tritium	84-86	interleukin 1 beta	Homo sapiens	38-46
8903852-7	1995	Treatment of brain cell cultures with IL-1beta plus TNF-alpha was found to inhibit [3H]-glutamate uptake and astrocyte glutamine synthetase activity, two major pathways involved in NMDA receptor-related neurotoxicity.	Glutamic Acid	88-97	interleukin 1 beta	Homo sapiens	38-46
8963837-5	1996	The LCE group showed a significantly lower stress response with respect to interleukin 1 beta, interleukin 6, epinephrine, norepinephrine and glucose.	LCE	4-7	interleukin 1 beta	Homo sapiens	75-93
8519653-6	1995	Interleukin 1 beta (IL-1 beta) also induced PGE2 production in breast fibroblasts in the presence of excess substrate, consistent with cyclo-oxygenase induction by the cytokine.	Dinoprostone	44-48	interleukin 1 beta	Homo sapiens	20-29
8519653-7	1995	Under these conditions only Hs578T cells and MDA-MB-231 cells demonstrated large increases in PGE2 in response to IL-1 beta or phorbol ester; no such responses were seen in MCF-7, T47-D, ZR-75-1, BT-20 or CLF-90-1 cells.	Dinoprostone	94-98	interleukin 1 beta	Homo sapiens	114-123
8519653-8	1995	In the absence of added arachidonate, bradykinin (BK) and endothelin-1 (ET-1), potentiated PGE2 production in IL-1 beta-treated fibroblasts, possibly by mobilising endogenous substrate.	Dinoprostone	91-95	interleukin 1 beta	Homo sapiens	110-119
7499971-5	1995	Thus, in these cells, YVAD-emk uncouples IL-1 beta processing and apoptosis.	YVAD	22-26	interleukin 1 beta	Homo sapiens	41-50
8964658-0	1995	Effect of peptide aldehydes with IL-1 beta converting enzyme inhibitory properties on IL-1 alpha and IL-1 beta production in vitro.	Aldehydes	18-27	interleukin 1 beta	Homo sapiens	33-42
8964658-1	1995	Tripeptide and pentapeptide aldehydes as substrate-base inhibitors of cysteine proteases were designed in our laboratory for the inhibition of interleukin-1 beta converting enzyme (ICE), a recently described cysteine protease responsible for the processing of IL-1 beta.	tripeptide K-26	0-10	interleukin 1 beta	Homo sapiens	260-269
8964658-1	1995	Tripeptide and pentapeptide aldehydes as substrate-base inhibitors of cysteine proteases were designed in our laboratory for the inhibition of interleukin-1 beta converting enzyme (ICE), a recently described cysteine protease responsible for the processing of IL-1 beta.	pentapeptide aldehydes	15-37	interleukin 1 beta	Homo sapiens	260-269
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	tripeptide K-26	4-14	interleukin 1 beta	Homo sapiens	118-127
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	Aldehydes	15-23	interleukin 1 beta	Homo sapiens	118-127
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	z-val-his	25-34	interleukin 1 beta	Homo sapiens	118-127
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	asp-h	35-40	interleukin 1 beta	Homo sapiens	118-127
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	Aldehydes	59-67	interleukin 1 beta	Homo sapiens	118-127
8964658-5	1995	The tripeptide aldehyde (Z-Val-His-Asp-H) and pentapeptide aldehyde (Eoc-Ala-Tyr-Val-Ala-Asp-H) significantly reduced IL-1 beta levels in the supernatants in relatively high concentrations (10-100 microM), but the IL-1 alpha release was unaffected by these peptides.	eoc-ala-tyr-val-ala-asp-h	69-94	interleukin 1 beta	Homo sapiens	118-127
8964658-9	1995	The peptide aldehydes suppressed the IL-1 beta production in a reversible manner, whereas dexamethasone, a glucocorticoid, had a prolonged inhibitory effect.	Aldehydes	12-21	interleukin 1 beta	Homo sapiens	37-46
8964658-11	1995	These findings indicate that these peptide aldehydes might be used as IL-beta inhibitory agents in experimental models in which IL-1 beta is a key mediator or ICE is implicated.	Aldehydes	43-52	interleukin 1 beta	Homo sapiens	128-137
7500055-10	1995	Exposure of OA-affected cartilage to interleukin 1 beta, tumor necrosis factor-alpha, and lipopolysaccharide resulted in approximately 20-50% augmentation of nitrite accumulation, which was also sensitive to cycloheximide and pyrrolidine dithiocarbamate.	Nitrites	158-165	interleukin 1 beta	Homo sapiens	37-84
7500055-10	1995	Exposure of OA-affected cartilage to interleukin 1 beta, tumor necrosis factor-alpha, and lipopolysaccharide resulted in approximately 20-50% augmentation of nitrite accumulation, which was also sensitive to cycloheximide and pyrrolidine dithiocarbamate.	Cycloheximide	208-221	interleukin 1 beta	Homo sapiens	37-84
7500055-10	1995	Exposure of OA-affected cartilage to interleukin 1 beta, tumor necrosis factor-alpha, and lipopolysaccharide resulted in approximately 20-50% augmentation of nitrite accumulation, which was also sensitive to cycloheximide and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	226-253	interleukin 1 beta	Homo sapiens	37-84
7594531-9	1995	IL-4 production by purified T cells stimulated by PHA or the combination of PMA with calcium ionophore (A23187) was inhibited by IL-1, and reconstitution with peripheral blood-derived adherent macrophages had no effect.	Calcium	85-92	interleukin 1 beta	Homo sapiens	129-133
7594531-9	1995	IL-4 production by purified T cells stimulated by PHA or the combination of PMA with calcium ionophore (A23187) was inhibited by IL-1, and reconstitution with peripheral blood-derived adherent macrophages had no effect.	Calcimycin	104-110	interleukin 1 beta	Homo sapiens	129-133
8751285-4	1995	Intravenous bolus injection of recombinant human IL-1beta (3 mu g/kg) caused a prompt and robust rise in plasma ACTH (peak, 748 +/- 183 (-x +/- SE) pg/ml at 20 min), but this was not associated with a significant change in plasma PGE2 up to 120 min postadministration.	Dinoprostone	230-234	interleukin 1 beta	Homo sapiens	49-57
8587246-8	1995	Inhibition study using protein kinase inhibitors revealed that MCP-1 mRNA expression induced by IL-1 beta and TNF-alpha was suppressed by the tyrosine kinase inhibitor genistein, not by the protein kinase C inhibitors staurosporine or H-7, or the protein kinase A inhibitor H-89, suggesting an important role of tyrosine kinase in the cytokine-induced MCP-1 gene expression.	Genistein	168-177	interleukin 1 beta	Homo sapiens	96-105
8587246-8	1995	Inhibition study using protein kinase inhibitors revealed that MCP-1 mRNA expression induced by IL-1 beta and TNF-alpha was suppressed by the tyrosine kinase inhibitor genistein, not by the protein kinase C inhibitors staurosporine or H-7, or the protein kinase A inhibitor H-89, suggesting an important role of tyrosine kinase in the cytokine-induced MCP-1 gene expression.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	274-278	interleukin 1 beta	Homo sapiens	96-105
8822445-5	1995	Our results indicate that progesterone synthesis by basal and human chorionic gonadotrophin (HCG)-stimulated granulosa cells co-cultured with white blood cells was inhibited by 5.0 ng/ml of IL-1 alpha and IL-1 beta at 48 h of culture.	Progesterone	26-38	interleukin 1 beta	Homo sapiens	205-214
8822445-6	1995	In the presence of white blood cells, granulosa cell oestradiol synthesis was inhibited by IL-1 beta but not IL-1 alpha.	Estradiol	53-63	interleukin 1 beta	Homo sapiens	91-100
8822445-7	1995	Oestradiol was inhibited after both 24 and 48 h of culture and was maximally affected by 5.0 ng/ml of IL-1 beta.	Estradiol	0-10	interleukin 1 beta	Homo sapiens	102-111
8822445-10	1995	Gonadal steroid inhibition by IL-1 alpha and IL-1 beta was not mediated through cytotoxic or antiproliferative effects on granulosa cells.	Steroids	8-15	interleukin 1 beta	Homo sapiens	45-54
8822445-11	1995	Specificity of the granulosa cell response to IL-1 alpha and IL-1 beta was demonstrated by abrogation of steroid inhibition with anti-IL-1 alpha and IL-1 beta neutralizing antibodies.	Steroids	105-112	interleukin 1 beta	Homo sapiens	61-70
8822445-11	1995	Specificity of the granulosa cell response to IL-1 alpha and IL-1 beta was demonstrated by abrogation of steroid inhibition with anti-IL-1 alpha and IL-1 beta neutralizing antibodies.	Steroids	105-112	interleukin 1 beta	Homo sapiens	149-158
8822445-13	1995	IL-1 alpha and IL-1 beta also exerted indirect effects on steroid production via white blood cells that are usually present in granulosa cell cultures if steps are not taken to remove them.	Steroids	58-65	interleukin 1 beta	Homo sapiens	15-24
8752503-2	1995	All epithelial cells exhibited constitutive NOS activity that was calcium-dependent, and inducible, lesser calcium-dependent activity in the presence of interferon-gamma, interleukin-1 beta, tumor necrosis factor-alpha, and lipopolysaccharide.	Calcium	107-114	interleukin 1 beta	Homo sapiens	171-218
8597057-3	1995	Pharmacological doses of the nitric oxide (NO) donor sodium nitroprusside (SNP) also conferred complete protection against TNF toxicity, suggesting a possible link between IL-1- and NO-induced protection.	Nitric Oxide	29-41	interleukin 1 beta	Homo sapiens	172-176
8824940-4	1995	Of note was that these two alkaloids appeared to inhibit IL-1 beta production more effectively than IL-1 alpha production.	Alkaloids	27-36	interleukin 1 beta	Homo sapiens	57-66
8824940-5	1995	When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively.	Alkaloids	81-90	interleukin 1 beta	Homo sapiens	126-135
8824940-5	1995	When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively.	Alkaloids	211-220	interleukin 1 beta	Homo sapiens	126-135
8597057-3	1995	Pharmacological doses of the nitric oxide (NO) donor sodium nitroprusside (SNP) also conferred complete protection against TNF toxicity, suggesting a possible link between IL-1- and NO-induced protection.	Nitroprusside	53-73	interleukin 1 beta	Homo sapiens	172-176
7477354-1	1995	The sphingomyelin pathway, initiated by hydrolysis of sphingomyelin to ceramide and stimulation of a Ser/Thr ceramide-activated protein (CAP) kinase, mediates tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta action.	Sphingomyelins	4-17	interleukin 1 beta	Homo sapiens	204-222
7594493-11	1995	Finally, IL-1 beta at high doses also induced iNOS mRNA and significant NO2- + NO3- production in cultures of primary human hepatocytes.	no2- + no3	72-82	interleukin 1 beta	Homo sapiens	9-18
7594450-2	1995	In the present study, using the recombinant plasmid pIL-1(4.0 kb)-chloramphenicol acetyltransferase, containing 4.0 kb of the IL-1 beta upstream regulatory sequence, we have demonstrated that dibutyryl cAMP treatment alone is capable of induction.	Cyclic AMP	202-206	interleukin 1 beta	Homo sapiens	126-135
7594450-0	1995	Cyclic AMP signaling pathways are important in IL-1 beta transcriptional regulation.	Cyclic AMP	0-10	interleukin 1 beta	Homo sapiens	47-56
7594450-1	1995	An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha.	Cyclic AMP	10-14	interleukin 1 beta	Homo sapiens	77-86
7594450-1	1995	An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha.	Cyclic AMP	10-14	interleukin 1 beta	Homo sapiens	153-162
7594450-1	1995	An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha.	Tetradecanoylphorbol Acetate	206-209	interleukin 1 beta	Homo sapiens	77-86
7594450-1	1995	An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha.	Tetradecanoylphorbol Acetate	206-209	interleukin 1 beta	Homo sapiens	153-162
7594450-10	1995	These studies confirm the importance of a cAMP signaling pathway(s) in the regulation of IL-1 beta at the transcriptional level.	Cyclic AMP	42-46	interleukin 1 beta	Homo sapiens	89-98
7488646-4	1995	Inhibition of IL-1 beta-stimulated PGE2 synthesis by indomethacin and direct addition of PGE2 had no effect on cyclic AMP levels, indicating that PGE2 did not increase cyclic AMP production by human decidual cells and confirming the independent synthesis of cyclic AMP and PGE2.	Dinoprostone	35-39	interleukin 1 beta	Homo sapiens	14-23
7488148-5	1995	The stimulatory effect of interleukin-1 beta is not associated with any change in the cellular levels of cAMP, indicating involvement of a cAMP-independent pathway.	Cyclic AMP	139-143	interleukin 1 beta	Homo sapiens	26-44
7592974-2	1995	Here, we present evidence that interleukin 1 beta (IL-1 beta) binding to normal human fibroblasts initiates a lipid messenger cascade that takes place in a sphingomyelin-rich plasma membrane domain with the characteristics of caveolae.	Sphingomyelins	156-169	interleukin 1 beta	Homo sapiens	31-49
7592974-2	1995	Here, we present evidence that interleukin 1 beta (IL-1 beta) binding to normal human fibroblasts initiates a lipid messenger cascade that takes place in a sphingomyelin-rich plasma membrane domain with the characteristics of caveolae.	Sphingomyelins	156-169	interleukin 1 beta	Homo sapiens	51-60
7592974-5	1995	The ceramide produced in response to IL-1 beta blocked platelet-derived growth factor-stimulated DNA synthesis.	Ceramides	4-12	interleukin 1 beta	Homo sapiens	37-46
7592974-6	1995	IL-1 beta stimulated the appearance of DAG in other fractions from the same cell, but this DAG was not coupled to ceramide production.	Diglycerides	39-42	interleukin 1 beta	Homo sapiens	0-9
7592974-6	1995	IL-1 beta stimulated the appearance of DAG in other fractions from the same cell, but this DAG was not coupled to ceramide production.	Diglycerides	91-94	interleukin 1 beta	Homo sapiens	0-9
7488646-0	1995	Interleukin-1 beta independently stimulates production of prostaglandin E2 and cyclic AMP from human decidual cells.	Dinoprostone	58-74	interleukin 1 beta	Homo sapiens	0-18
7488646-4	1995	Inhibition of IL-1 beta-stimulated PGE2 synthesis by indomethacin and direct addition of PGE2 had no effect on cyclic AMP levels, indicating that PGE2 did not increase cyclic AMP production by human decidual cells and confirming the independent synthesis of cyclic AMP and PGE2.	Indomethacin	53-65	interleukin 1 beta	Homo sapiens	14-23
7488646-0	1995	Interleukin-1 beta independently stimulates production of prostaglandin E2 and cyclic AMP from human decidual cells.	Cyclic AMP	79-89	interleukin 1 beta	Homo sapiens	0-18
7488646-1	1995	Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (&lt; 6 h).	Cyclic AMP	59-69	interleukin 1 beta	Homo sapiens	0-18
7497463-3	1995	In this paper, data are summarized revealing the ability of WBH to induce elevated plasma levels of granulocyte-colony stimulating factor (G-CSF), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) within hours of WBH.	wbh	60-63	interleukin 1 beta	Homo sapiens	147-165
7497463-3	1995	In this paper, data are summarized revealing the ability of WBH to induce elevated plasma levels of granulocyte-colony stimulating factor (G-CSF), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) within hours of WBH.	wbh	60-63	interleukin 1 beta	Homo sapiens	167-176
7488646-5	1995	The increase in cyclic AMP production induced by IL-1 beta is dependent on protein synthesis, but it is not known which component of the adenylate cyclase is increased.	Cyclic AMP	16-26	interleukin 1 beta	Homo sapiens	49-58
7488646-1	1995	Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (&lt; 6 h).	Cyclic AMP	59-69	interleukin 1 beta	Homo sapiens	20-29
7488646-1	1995	Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (&lt; 6 h).	Dinoprostone	74-90	interleukin 1 beta	Homo sapiens	0-18
7488646-6	1995	A phosphodiesterase inhibitor potentiated the effects of IL-1 beta on cyclic AMP synthesis, indicating that the cytokine may increase cyclic AMP metabolism.	Cyclic AMP	70-80	interleukin 1 beta	Homo sapiens	57-66
7488646-1	1995	Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (&lt; 6 h).	Dinoprostone	74-90	interleukin 1 beta	Homo sapiens	20-29
7488646-1	1995	Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (&lt; 6 h).	Dinoprostone	92-96	interleukin 1 beta	Homo sapiens	0-18
7488646-6	1995	A phosphodiesterase inhibitor potentiated the effects of IL-1 beta on cyclic AMP synthesis, indicating that the cytokine may increase cyclic AMP metabolism.	Cyclic AMP	134-144	interleukin 1 beta	Homo sapiens	57-66
7488646-1	1995	Interleukin-1 beta (IL-1 beta) increased the production of cyclic AMP and prostaglandin E2 (PGE2) by cultured human decidual cells during 24 h of stimulation, but not over short incubation times (&lt; 6 h).	Dinoprostone	92-96	interleukin 1 beta	Homo sapiens	20-29
7488646-7	1995	We suggest that high concentrations of IL-1 beta activate phosphodiesterase activity more than adenylate cyclase, which gives rise to the low levels of cyclic AMP noted above.	Cyclic AMP	152-162	interleukin 1 beta	Homo sapiens	39-48
7488646-2	1995	At concentrations of IL-1 beta ranging from 1 to 100 pg/ml, there were parallel changes in cyclic AMP and PGE2 levels, but 1000 pg of IL-1 beta/ml inhibited cyclic AMP production while still stimulating PGE2 synthesis.	Cyclic AMP	91-101	interleukin 1 beta	Homo sapiens	21-30
7488646-8	1995	IL-1 beta also decreased forskolin-stimulated cyclic AMP production, which again indicates increased cyclic AMP metabolism.	Colforsin	25-34	interleukin 1 beta	Homo sapiens	0-9
7488646-2	1995	At concentrations of IL-1 beta ranging from 1 to 100 pg/ml, there were parallel changes in cyclic AMP and PGE2 levels, but 1000 pg of IL-1 beta/ml inhibited cyclic AMP production while still stimulating PGE2 synthesis.	Dinoprostone	106-110	interleukin 1 beta	Homo sapiens	21-30
7488646-2	1995	At concentrations of IL-1 beta ranging from 1 to 100 pg/ml, there were parallel changes in cyclic AMP and PGE2 levels, but 1000 pg of IL-1 beta/ml inhibited cyclic AMP production while still stimulating PGE2 synthesis.	Cyclic AMP	157-167	interleukin 1 beta	Homo sapiens	134-143
7488646-8	1995	IL-1 beta also decreased forskolin-stimulated cyclic AMP production, which again indicates increased cyclic AMP metabolism.	Cyclic AMP	46-56	interleukin 1 beta	Homo sapiens	0-9
7488646-8	1995	IL-1 beta also decreased forskolin-stimulated cyclic AMP production, which again indicates increased cyclic AMP metabolism.	Cyclic AMP	101-111	interleukin 1 beta	Homo sapiens	0-9
7488646-9	1995	Since most concentrations of IL-1 beta alone increased cyclic AMP levels, this stimulation must out-weigh the increase in metabolism apparent in the presence of forskolin, phosphodiesterase inhibitor or high levels of interleukin.	Cyclic AMP	55-65	interleukin 1 beta	Homo sapiens	29-38
7488646-10	1995	It is clear that IL-1 beta increased decidual PGE2 production independently of cyclic AMP, and that other second messenger must mediate the action of this cytokine.	Dinoprostone	46-50	interleukin 1 beta	Homo sapiens	17-26
7576691-6	1995	Furthermore, treatment of REC monolayers with TNF-alpha or IL-1 beta significantly increased adhesion of PMA-stimulated eosinophils (P &lt; 0.01).	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Homo sapiens	59-68
8574830-3	1995	PTX, theofylline, and DXM inhibited the release of IL-1 beta, but caffeine did not affect IL-1 beta release.	Pentoxifylline	0-3	interleukin 1 beta	Homo sapiens	51-60
8574830-3	1995	PTX, theofylline, and DXM inhibited the release of IL-1 beta, but caffeine did not affect IL-1 beta release.	theofylline	5-16	interleukin 1 beta	Homo sapiens	51-60
8574830-3	1995	PTX, theofylline, and DXM inhibited the release of IL-1 beta, but caffeine did not affect IL-1 beta release.	Dexamethasone	22-25	interleukin 1 beta	Homo sapiens	51-60
8597883-1	1995	We performed an open, between patients, placebo controlled study in order to evaluate the effect of the treatment with the non steroidal anti inflammatory drugs indomethacin, diclofenac and naproxen on the concentrations of the cytokines IL-1 beta and IL-6 and of the neuropeptide substance P in plasma and synovial fluid of 24 rheumatoid arthritis patients.	Indomethacin	161-173	interleukin 1 beta	Homo sapiens	238-247
8563892-4	1995	Patients with non-refractory active UC receiving steroids showed levels of IL-1 beta and TNF-beta production similar to those in controls.	Steroids	49-57	interleukin 1 beta	Homo sapiens	75-84
7589278-0	1995	The effects of interleukin-1 beta and tumor necrosis factor-alpha on in vitro colony formation by human hematopoietic progenitor cells exposed to doxorubicin or hydroquinone.	hydroquinone	161-173	interleukin 1 beta	Homo sapiens	15-65
7589278-1	1995	Previous studies have shown that treatment of bone marrow (BM) cells with interleukin-1 beta (IL-1 beta) or tumor necrosis factor-alpha (TNF-alpha) can protect hematopoietic progenitor cells (HPC) from the toxic effects of 4-hydroperoxycyclophosphamide (4HC) or gamma-irradiation.	perfosfamide	223-252	interleukin 1 beta	Homo sapiens	74-92
7589278-1	1995	Previous studies have shown that treatment of bone marrow (BM) cells with interleukin-1 beta (IL-1 beta) or tumor necrosis factor-alpha (TNF-alpha) can protect hematopoietic progenitor cells (HPC) from the toxic effects of 4-hydroperoxycyclophosphamide (4HC) or gamma-irradiation.	perfosfamide	223-252	interleukin 1 beta	Homo sapiens	94-103
7589278-1	1995	Previous studies have shown that treatment of bone marrow (BM) cells with interleukin-1 beta (IL-1 beta) or tumor necrosis factor-alpha (TNF-alpha) can protect hematopoietic progenitor cells (HPC) from the toxic effects of 4-hydroperoxycyclophosphamide (4HC) or gamma-irradiation.	perfosfamide	254-257	interleukin 1 beta	Homo sapiens	74-92
7589278-1	1995	Previous studies have shown that treatment of bone marrow (BM) cells with interleukin-1 beta (IL-1 beta) or tumor necrosis factor-alpha (TNF-alpha) can protect hematopoietic progenitor cells (HPC) from the toxic effects of 4-hydroperoxycyclophosphamide (4HC) or gamma-irradiation.	perfosfamide	254-257	interleukin 1 beta	Homo sapiens	94-103
8592949-6	1995	Alendronate exhibited dose-dependent inhibition of the production of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) by activated monocytes.	Alendronate	0-11	interleukin 1 beta	Homo sapiens	69-87
8592949-6	1995	Alendronate exhibited dose-dependent inhibition of the production of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) by activated monocytes.	Alendronate	0-11	interleukin 1 beta	Homo sapiens	89-98
8592949-8	1995	Thus, alendronate acts on monocytes to inhibit their antigen-presenting/accessory cell functions through a mechanism that can be overcome by exogenous IL-1.	Alendronate	6-17	interleukin 1 beta	Homo sapiens	151-155
7595061-5	1995	Cycloheximide treatment of the cultures containing M-CSF and IFN-gamma inhibited the production of IL-1 beta and TNF-alpha.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	99-108
8597883-1	1995	We performed an open, between patients, placebo controlled study in order to evaluate the effect of the treatment with the non steroidal anti inflammatory drugs indomethacin, diclofenac and naproxen on the concentrations of the cytokines IL-1 beta and IL-6 and of the neuropeptide substance P in plasma and synovial fluid of 24 rheumatoid arthritis patients.	Diclofenac	175-185	interleukin 1 beta	Homo sapiens	238-247
8597883-1	1995	We performed an open, between patients, placebo controlled study in order to evaluate the effect of the treatment with the non steroidal anti inflammatory drugs indomethacin, diclofenac and naproxen on the concentrations of the cytokines IL-1 beta and IL-6 and of the neuropeptide substance P in plasma and synovial fluid of 24 rheumatoid arthritis patients.	Naproxen	190-198	interleukin 1 beta	Homo sapiens	238-247
7592669-1	1995	In order to better understand the significance of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta)-receptor internalization in the sphingomyelin pathway signal transduction, we investigated receptor signaling under conditions in which receptor internalization is blocked.	Sphingomyelins	157-170	interleukin 1 beta	Homo sapiens	94-112
7479785-0	1995	Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes.	inorganic pyrophosphate	65-88	interleukin 1 beta	Homo sapiens	0-18
8788239-6	1995	The in vitro production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) was measured after mitogen stimulation with lipopolisaccharide from E. coli (LPS).	lipopolisaccharide	146-164	interleukin 1 beta	Homo sapiens	47-56
7592669-1	1995	In order to better understand the significance of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta)-receptor internalization in the sphingomyelin pathway signal transduction, we investigated receptor signaling under conditions in which receptor internalization is blocked.	Sphingomyelins	157-170	interleukin 1 beta	Homo sapiens	114-123
7592669-2	1995	We demonstrate that human recombinant TNF-alpha and IL-1 beta both induced sphingomyelin and phosphatidylcholine hydrolysis at either 4, 14, or 37 degrees C in human skin fibroblasts and U937 monocytic cells.	Sphingomyelins	75-88	interleukin 1 beta	Homo sapiens	52-61
7592669-2	1995	We demonstrate that human recombinant TNF-alpha and IL-1 beta both induced sphingomyelin and phosphatidylcholine hydrolysis at either 4, 14, or 37 degrees C in human skin fibroblasts and U937 monocytic cells.	Phosphatidylcholines	93-112	interleukin 1 beta	Homo sapiens	52-61
7575617-1	1995	Human retinal pigment epithelial (RPE) cells in culture respond to a mixture of cytokines (IFN-gamma, IL-1 beta, TNF-alpha) by producing large amounts of nitric oxide.	Nitric Oxide	154-166	interleukin 1 beta	Homo sapiens	102-111
7568157-5	1995	Formation was enhanced by cytokines (interleukin 1 beta) that induced the appearance of prostaglandin G/H synthase 2 (PGHS-2) but not 15-lipoxygenase, which initiates their biosynthesis from arachidonic acid in HUVEC.	Arachidonic Acid	191-207	interleukin 1 beta	Homo sapiens	37-55
8593446-0	1995	Effect of theophylline on the production of interleukin-1 beta, tumor necrosis factor-alpha, and interleukin-8 by human peripheral blood mononuclear cells.	Theophylline	10-22	interleukin 1 beta	Homo sapiens	44-62
8526804-3	1995	In situ hybridization using digoxigenin-labelled oligonucleotide probe complementary to human IL-1 beta mRNA showed IL-1 transcripts in both polymorphonuclear leucocytes and mononuclear cells but not in epithelial cells in all GCW samples from diseased and healthy sites.	Digoxigenin	28-39	interleukin 1 beta	Homo sapiens	94-103
8526804-3	1995	In situ hybridization using digoxigenin-labelled oligonucleotide probe complementary to human IL-1 beta mRNA showed IL-1 transcripts in both polymorphonuclear leucocytes and mononuclear cells but not in epithelial cells in all GCW samples from diseased and healthy sites.	Oligonucleotides	49-64	interleukin 1 beta	Homo sapiens	94-103
8593446-4	1995	IL-1 beta production showed 23% suppression by 10 micrograms/ml theophylline (p &lt; 0.05), while the suppression was 26% at 25 micrograms/ml (p &lt; 0.05), 30% at 50 micrograms/ml (p &lt; 0.05), and 33% at 100 micrograms/ml (p &lt; 0.05).	Theophylline	64-76	interleukin 1 beta	Homo sapiens	0-9
8593446-8	1995	Suppression of the production of IL-1 beta and TNF-alpha by therapeutic levels of theophylline suggested that this drug might have anti-inflammatory and immunosuppressive effects.	Theophylline	82-94	interleukin 1 beta	Homo sapiens	33-42
8589297-9	1995	The release of IL-1 beta and TNF-alpha after 6 h by recirculating lymphomonocytes paralleled the NO synthase activity profile in endothelial cells and was significantly higher after cuprophan exposure than after polymethylmethacrylate (P &lt; 0.0001).	cuprammonium cellulose	182-191	interleukin 1 beta	Homo sapiens	15-24
7552526-9	1995	IL-1 beta suppressed production of uPA and tPA in both types of SMCs.	Tetradecanoylphorbol Acetate	43-46	interleukin 1 beta	Homo sapiens	0-9
8543370-1	1995	The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied.	Dinoprostone	133-149	interleukin 1 beta	Homo sapiens	14-32
8543370-1	1995	The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied.	Dinoprostone	133-149	interleukin 1 beta	Homo sapiens	34-43
8543370-1	1995	The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied.	Dinoprostone	151-155	interleukin 1 beta	Homo sapiens	14-32
8543370-1	1995	The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied.	Dinoprostone	151-155	interleukin 1 beta	Homo sapiens	34-43
8543370-5	1995	When gingival fibroblasts were treated simultaneously with IL-1 beta and PMA, the cytokine IL-1 beta synergistically increased levels of COX-2 mRNA, accompanied by a corresponding increase in PGE2 biosynthesis.	Dinoprostone	192-196	interleukin 1 beta	Homo sapiens	59-68
8543370-5	1995	When gingival fibroblasts were treated simultaneously with IL-1 beta and PMA, the cytokine IL-1 beta synergistically increased levels of COX-2 mRNA, accompanied by a corresponding increase in PGE2 biosynthesis.	Dinoprostone	192-196	interleukin 1 beta	Homo sapiens	91-100
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Steroids	22-29	interleukin 1 beta	Homo sapiens	136-145
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Steroids	22-29	interleukin 1 beta	Homo sapiens	173-182
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dexamethasone	31-44	interleukin 1 beta	Homo sapiens	136-145
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dexamethasone	31-44	interleukin 1 beta	Homo sapiens	173-182
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dexamethasone	46-49	interleukin 1 beta	Homo sapiens	136-145
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dexamethasone	46-49	interleukin 1 beta	Homo sapiens	173-182
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dinoprostone	110-114	interleukin 1 beta	Homo sapiens	136-145
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dinoprostone	110-114	interleukin 1 beta	Homo sapiens	173-182
8543370-7	1995	The study indicates that the IL-1 beta induced PGE2 formation is mediated by an enhanced gene expression of COX-2 in gingival fibroblasts suggesting that the enzyme COX-2 may play an important role in the regulation of prostanoid formation at inflammatory lesions in gingival tissue.	Dinoprostone	47-51	interleukin 1 beta	Homo sapiens	29-38
8543370-7	1995	The study indicates that the IL-1 beta induced PGE2 formation is mediated by an enhanced gene expression of COX-2 in gingival fibroblasts suggesting that the enzyme COX-2 may play an important role in the regulation of prostanoid formation at inflammatory lesions in gingival tissue.	Prostaglandins	219-229	interleukin 1 beta	Homo sapiens	29-38
7485516-6	1995	In PBM, dexamethasone (10(-6) M) reduced LPS- and IL-1 beta-stimulated production of MIP-1 alpha protein by 50 and 63%, respectively, maximally at 24 h, whereas the inhibition of mRNA expression occurred maximally at 4 h. Similar trends were observed for AM.	pbm	3-6	interleukin 1 beta	Homo sapiens	50-59
7485516-6	1995	In PBM, dexamethasone (10(-6) M) reduced LPS- and IL-1 beta-stimulated production of MIP-1 alpha protein by 50 and 63%, respectively, maximally at 24 h, whereas the inhibition of mRNA expression occurred maximally at 4 h. Similar trends were observed for AM.	Dexamethasone	8-21	interleukin 1 beta	Homo sapiens	50-59
7559807-7	1995	Similarly, 5,8,11,14 eicosatetraynoic acid (ETYA), another inhibitor of the arachidonic acid pathway, blocked the induction of transcripts for TNF-alpha, and both IL-1 genes in phorbol ester-stimulated HL 60 cells.	5,8,11,14-Eicosatetraynoic Acid	11-42	interleukin 1 beta	Homo sapiens	163-167
7559807-0	1995	Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.	Arachidonic Acid	18-34	interleukin 1 beta	Homo sapiens	224-233
8589297-9	1995	The release of IL-1 beta and TNF-alpha after 6 h by recirculating lymphomonocytes paralleled the NO synthase activity profile in endothelial cells and was significantly higher after cuprophan exposure than after polymethylmethacrylate (P &lt; 0.0001).	Polymethyl Methacrylate	212-234	interleukin 1 beta	Homo sapiens	15-24
7559890-5	1995	Exposure of GLCs to IL-1 resulted in a 50% increase in PGE production, a 33% suppression of PA activity, and a 75% increase in the ability of the corresponding conditioned media to inhibit exogenous urokinase activity.	Prostaglandins E	55-58	interleukin 1 beta	Homo sapiens	20-24
7559807-7	1995	Similarly, 5,8,11,14 eicosatetraynoic acid (ETYA), another inhibitor of the arachidonic acid pathway, blocked the induction of transcripts for TNF-alpha, and both IL-1 genes in phorbol ester-stimulated HL 60 cells.	ETYA	44-48	interleukin 1 beta	Homo sapiens	163-167
7559807-7	1995	Similarly, 5,8,11,14 eicosatetraynoic acid (ETYA), another inhibitor of the arachidonic acid pathway, blocked the induction of transcripts for TNF-alpha, and both IL-1 genes in phorbol ester-stimulated HL 60 cells.	Arachidonic Acid	76-92	interleukin 1 beta	Homo sapiens	163-167
7559807-7	1995	Similarly, 5,8,11,14 eicosatetraynoic acid (ETYA), another inhibitor of the arachidonic acid pathway, blocked the induction of transcripts for TNF-alpha, and both IL-1 genes in phorbol ester-stimulated HL 60 cells.	Phorbol Esters	177-190	interleukin 1 beta	Homo sapiens	163-167
7559890-7	1995	Exposure of GLCs to IL-1 receptor antagonist abolished the ability of IL-1 to enhance PA inhibitory activity and PGE production, thereby establishing specific IL-1 receptor-mediated effects.	Prostaglandins E	113-116	interleukin 1 beta	Homo sapiens	20-24
8569088-8	1995	Conversely, raising intracellular cyclic-AMP levels, or exposing mesangial cells to herbimycin A, treatments that block IL-1-induced MCP-1 mRNA expression, significantly attenuated NF-kappa B activation.	herbimycin	84-96	interleukin 1 beta	Homo sapiens	120-124
7559890-7	1995	Exposure of GLCs to IL-1 receptor antagonist abolished the ability of IL-1 to enhance PA inhibitory activity and PGE production, thereby establishing specific IL-1 receptor-mediated effects.	Prostaglandins E	113-116	interleukin 1 beta	Homo sapiens	70-74
7559890-8	1995	The ability of IL-1 to suppress PA activity and to produce PAI-1 persisted in the presence of indomethacin, a potent inhibitor of PG synthesis.	Indomethacin	94-106	interleukin 1 beta	Homo sapiens	15-19
7559890-8	1995	The ability of IL-1 to suppress PA activity and to produce PAI-1 persisted in the presence of indomethacin, a potent inhibitor of PG synthesis.	Prostaglandins	130-132	interleukin 1 beta	Homo sapiens	15-19
7559890-9	1995	Likewise, transforming growth factor-beta 1 suppressed the ability of IL-1 to stimulate PGE production without affecting the IL-1-induced effects on the PA system.	Prostaglandins E	88-91	interleukin 1 beta	Homo sapiens	70-74
7559890-10	1995	The present findings suggest a pluripotent response of GLCs to IL-1, characterized by the induction of PAI-1 and the suppression of PA occurring concurrent with, but independent of, PG production.	Prostaglandins	182-184	interleukin 1 beta	Homo sapiens	63-67
8576941-4	1995	Vesnarinone [OPC-8212; 3,4-dihydro-6-(4-(3,4-dimethoxybenzoil)-1-piperazinyl)-2(1H)- quinolinone] at 26 mumol/l significantly suppressed the production of IL-6, granulocyte macrophage colony stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF) induced by IL-1 beta.	vesnarinone	0-11	interleukin 1 beta	Homo sapiens	280-289
8576941-4	1995	Vesnarinone [OPC-8212; 3,4-dihydro-6-(4-(3,4-dimethoxybenzoil)-1-piperazinyl)-2(1H)- quinolinone] at 26 mumol/l significantly suppressed the production of IL-6, granulocyte macrophage colony stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF) induced by IL-1 beta.	vesnarinone	13-21	interleukin 1 beta	Homo sapiens	280-289
8576941-4	1995	Vesnarinone [OPC-8212; 3,4-dihydro-6-(4-(3,4-dimethoxybenzoil)-1-piperazinyl)-2(1H)- quinolinone] at 26 mumol/l significantly suppressed the production of IL-6, granulocyte macrophage colony stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF) induced by IL-1 beta.	3,4-dihydro-6-(4-(3,4-dimethoxybenzoil)-1-piperazinyl)-2(1h)- quinolinone	23-96	interleukin 1 beta	Homo sapiens	280-289
7562566-0	1995	Arachidonic acid cascade and stimulation of acetylcholine release by human recombinant interleukin-1 beta in guinea pig ileum.	Arachidonic Acid	0-16	interleukin 1 beta	Homo sapiens	87-105
7562566-0	1995	Arachidonic acid cascade and stimulation of acetylcholine release by human recombinant interleukin-1 beta in guinea pig ileum.	Acetylcholine	44-57	interleukin 1 beta	Homo sapiens	87-105
8569088-9	1995	Finally, blocking the synthesis of one of the protein subunits of NF-kappa B with an antisense oligonucleotide decreased MCP-1 mRNA levels in response to IL-1.	Oligonucleotides	95-110	interleukin 1 beta	Homo sapiens	154-158
7575673-8	1995	Manoalide and scalaradial also inhibited the release of IL-1 beta and TNF alpha from LPS-stimulated monocytes.	manoalide	0-9	interleukin 1 beta	Homo sapiens	56-65
7545088-5	1995	We have also demonstrated that the adhesion of tumor cells to IL-1 beta-treated human umbilical vein endothelial cells can be inhibited by anti-NF kappa B reagents such as N-acetyl L-cysteine, aspirin, or pentoxifylline.	Acetylcysteine	172-191	interleukin 1 beta	Homo sapiens	62-71
7575673-11	1995	Scalaradial and to some extent manoalide were capable of blocking the IL-1 beta-induced expression of PHGS-2.	manoalide	31-40	interleukin 1 beta	Homo sapiens	70-79
7545088-5	1995	We have also demonstrated that the adhesion of tumor cells to IL-1 beta-treated human umbilical vein endothelial cells can be inhibited by anti-NF kappa B reagents such as N-acetyl L-cysteine, aspirin, or pentoxifylline.	Aspirin	193-200	interleukin 1 beta	Homo sapiens	62-71
7545088-5	1995	We have also demonstrated that the adhesion of tumor cells to IL-1 beta-treated human umbilical vein endothelial cells can be inhibited by anti-NF kappa B reagents such as N-acetyl L-cysteine, aspirin, or pentoxifylline.	Pentoxifylline	205-219	interleukin 1 beta	Homo sapiens	62-71
8552275-4	1995	Actinomycin D, inhibited C3 gene induction by IFN-gamma and IL-1 beta suggesting that these cytokines act, in part, at the transcriptional level to enhance C3 expression.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	60-69
7543934-1	1995	A nitric oxide (NO) synthase (NOS) can be induced in both astrocytes and cerebral endothelial cells with a combination of interleukin-1 beta/interferon-gamma or lipopolysaccharide/interferon-gamma, respectively.	Nitric Oxide	2-14	interleukin 1 beta	Homo sapiens	122-140
7545059-10	1995	Our findings document local elevations of IL-1 beta, GM-CSF, and chemokines in the nasal secretions after allergen challenges and their inhibition by steroids.	Steroids	150-158	interleukin 1 beta	Homo sapiens	42-51
11854837-0	1995	Tyrosine Phosphorylation: Biochemical Events Involved in Cyclooxygenase II Activation by IL-1beta Interleukin-1 induced the expression of cyclooxygenase II in renal mesangial cells.	Tyrosine	0-8	interleukin 1 beta	Homo sapiens	89-93
11854837-2	1995	Cycloheximide superinduced the message for COX II in the presence of IL-1beta.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	69-77
11854837-4	1995	Genistein, an inhibitor of tyrosine phosphorylation completely inhibited the ability of IL-1beta to induce the COX II message.	Genistein	0-9	interleukin 1 beta	Homo sapiens	88-96
11854837-4	1995	Genistein, an inhibitor of tyrosine phosphorylation completely inhibited the ability of IL-1beta to induce the COX II message.	Tyrosine	27-35	interleukin 1 beta	Homo sapiens	88-96
11854837-6	1995	These studies confirm the dependency of tyrosine phosphorylation in the IL-1beta induced expression of COX II message and protein.	Tyrosine	40-48	interleukin 1 beta	Homo sapiens	72-80
11854839-1	1995	The effect of misoprostol on interleukin-1beta (IL-1beta)-mediated phospholipid metabolism, arachidonic acid release, and prostaglandin E(2) (PGE(2)) production was examined using normal skin fibroblasts and synovial fibroblasts from patients with osteoarthritis.	Misoprostol	14-25	interleukin 1 beta	Homo sapiens	29-46
11854839-1	1995	The effect of misoprostol on interleukin-1beta (IL-1beta)-mediated phospholipid metabolism, arachidonic acid release, and prostaglandin E(2) (PGE(2)) production was examined using normal skin fibroblasts and synovial fibroblasts from patients with osteoarthritis.	Phospholipids	67-79	interleukin 1 beta	Homo sapiens	29-46
11854839-1	1995	The effect of misoprostol on interleukin-1beta (IL-1beta)-mediated phospholipid metabolism, arachidonic acid release, and prostaglandin E(2) (PGE(2)) production was examined using normal skin fibroblasts and synovial fibroblasts from patients with osteoarthritis.	Phospholipids	67-79	interleukin 1 beta	Homo sapiens	48-56
11854839-2	1995	We found that both IL-1beta and misoprostol induced arachidonic acid release, suggesting enhanced phospholipase A(2) activation.	Arachidonic Acid	52-68	interleukin 1 beta	Homo sapiens	19-27
11854839-3	1995	Both Il-1beta and IL-1beta/misoprostol, but not misoprostol alone, induced a significant increase in PGE(2) levels compared with controls.	Prostaglandins E	101-104	interleukin 1 beta	Homo sapiens	5-13
11854839-3	1995	Both Il-1beta and IL-1beta/misoprostol, but not misoprostol alone, induced a significant increase in PGE(2) levels compared with controls.	Prostaglandins E	101-104	interleukin 1 beta	Homo sapiens	18-26
11854839-4	1995	Even though PGE(2) production was not significantly increased by misoprostol alone, misoprostol synergistically enhanced IL-1beta-mediated cyclooxygenase activity (sixfold to eightfold) and PGE(2) synthesis in normal fibroblasts but not in OA synovial fibroblasts.	Misoprostol	84-95	interleukin 1 beta	Homo sapiens	121-129
8564236-3	1995	Incubation (3 h) with human recombinant interleukin-1 beta (IL-1 beta) selectively amplified the contractile response to the B1 receptor agonist Sar-[D-Phe8]des-Arg9-BK, while it did not affect the contractile effect of other agents (angiotensin II, endothelin-1, phenylephrine).	sar-[d-phe8]des-arg9-bk	145-168	interleukin 1 beta	Homo sapiens	40-58
8564236-3	1995	Incubation (3 h) with human recombinant interleukin-1 beta (IL-1 beta) selectively amplified the contractile response to the B1 receptor agonist Sar-[D-Phe8]des-Arg9-BK, while it did not affect the contractile effect of other agents (angiotensin II, endothelin-1, phenylephrine).	sar-[d-phe8]des-arg9-bk	145-168	interleukin 1 beta	Homo sapiens	60-69
8564236-3	1995	Incubation (3 h) with human recombinant interleukin-1 beta (IL-1 beta) selectively amplified the contractile response to the B1 receptor agonist Sar-[D-Phe8]des-Arg9-BK, while it did not affect the contractile effect of other agents (angiotensin II, endothelin-1, phenylephrine).	Phenylephrine	264-277	interleukin 1 beta	Homo sapiens	40-58
8564236-3	1995	Incubation (3 h) with human recombinant interleukin-1 beta (IL-1 beta) selectively amplified the contractile response to the B1 receptor agonist Sar-[D-Phe8]des-Arg9-BK, while it did not affect the contractile effect of other agents (angiotensin II, endothelin-1, phenylephrine).	Phenylephrine	264-277	interleukin 1 beta	Homo sapiens	60-69
7544275-14	1995	The addition of cycloheximide markedly inhibited IL-1 beta-induced IGFBP-3 mRNA levels.	Cycloheximide	16-29	interleukin 1 beta	Homo sapiens	49-58
7544275-15	1995	However, IL-1 beta was able to induce IGFBP-3 mRNA levels even in the presence of cycloheximide.	Cycloheximide	82-95	interleukin 1 beta	Homo sapiens	9-18
8847103-4	1995	On the contrary, ATP and glutamate treatment of astrocytes prior to a combination of interleukin-1 beta and interferon-gamma markedly reduced (30-50%) subsequent NOS mRNA expression.	Adenosine Triphosphate	17-20	interleukin 1 beta	Homo sapiens	85-103
8847103-4	1995	On the contrary, ATP and glutamate treatment of astrocytes prior to a combination of interleukin-1 beta and interferon-gamma markedly reduced (30-50%) subsequent NOS mRNA expression.	Glutamic Acid	25-34	interleukin 1 beta	Homo sapiens	85-103
8847103-6	1995	The effects of ATP and glutamate were additive and could be mimicked by selective receptor agonists, but were insensitive to a specific inhibitor of protein kinase C. The inhibition of cytokine-induced NOS mRNA expression caused by these agents was not the result of interference with the activation/translocation of nuclear factor-Kappa Beta by interleukin-1 beta.	Adenosine Triphosphate	15-18	interleukin 1 beta	Homo sapiens	346-364
8847103-6	1995	The effects of ATP and glutamate were additive and could be mimicked by selective receptor agonists, but were insensitive to a specific inhibitor of protein kinase C. The inhibition of cytokine-induced NOS mRNA expression caused by these agents was not the result of interference with the activation/translocation of nuclear factor-Kappa Beta by interleukin-1 beta.	Glutamic Acid	23-32	interleukin 1 beta	Homo sapiens	346-364
7544757-0	1995	Downregulation of phorbol 12-myristate 13-acetate-induced tumor necrosis factor-alpha and interleukin-1 beta production and gene expression in human monocytic cells by human alpha-fetoprotein.	Tetradecanoylphorbol Acetate	18-49	interleukin 1 beta	Homo sapiens	90-108
7544757-4	1995	Our results showed that U937 cells secreted TNF-alpha and IL-1 beta in response to either phorbyl 12-myristate 13-acetate (PMA) or IFN-gamma + LPS.	phorbyl 12-myristate 13-acetate	90-121	interleukin 1 beta	Homo sapiens	58-67
11854839-6	1995	Together, the results suggest that misoprostol may upregulate the conversion of arachidonic acid to PGE(2) by enhancing the IL-1beta-induced activation/synthesis of cyclooxygenase.	Misoprostol	35-46	interleukin 1 beta	Homo sapiens	124-132
11854839-6	1995	Together, the results suggest that misoprostol may upregulate the conversion of arachidonic acid to PGE(2) by enhancing the IL-1beta-induced activation/synthesis of cyclooxygenase.	Arachidonic Acid	80-96	interleukin 1 beta	Homo sapiens	124-132
11854839-6	1995	Together, the results suggest that misoprostol may upregulate the conversion of arachidonic acid to PGE(2) by enhancing the IL-1beta-induced activation/synthesis of cyclooxygenase.	Prostaglandins E	100-103	interleukin 1 beta	Homo sapiens	124-132
7544757-4	1995	Our results showed that U937 cells secreted TNF-alpha and IL-1 beta in response to either phorbyl 12-myristate 13-acetate (PMA) or IFN-gamma + LPS.	Tetradecanoylphorbol Acetate	123-126	interleukin 1 beta	Homo sapiens	58-67
7544757-5	1995	In contrast, AFP significantly suppressed PMA-induced TNF-alpha and IL-1 beta production by U937 cells in a time and dose dependent fashion.	Tetradecanoylphorbol Acetate	42-45	interleukin 1 beta	Homo sapiens	68-77
7544757-11	1995	Thus, we conclude that AFP downregulates TNF-alpha and IL-1 beta production via a PGE2-dependent mechanism.	Dinoprostone	82-86	interleukin 1 beta	Homo sapiens	55-64
8655918-6	1995	At 4-24 h period, IL-1 dose-dependently inhibited cyclic AMP production, accompanied with a significant reduction of insulin secretion.	Cyclic AMP	50-60	interleukin 1 beta	Homo sapiens	18-22
8655918-9	1995	These data indicated that maintaining adequate intracellular pH levels may be important in the IL-1 effects on insulin secretion by the mechanism in which cyclic AMP may not be involved.	Cyclic AMP	155-165	interleukin 1 beta	Homo sapiens	95-99
7665990-0	1995	Inhibition of superantigen-induced T cell proliferation and monocyte IL-1 beta, TNF-alpha, and IL-6 production by acute ethanol treatment.	Ethanol	120-127	interleukin 1 beta	Homo sapiens	69-78
7665990-3	1995	Furthermore, ethanol treatment (25-100 mM) significantly inhibited SEA- or SEB-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and IL-6 in monocytes.	Ethanol	13-20	interleukin 1 beta	Homo sapiens	142-160
7665990-3	1995	Furthermore, ethanol treatment (25-100 mM) significantly inhibited SEA- or SEB-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and IL-6 in monocytes.	Ethanol	13-20	interleukin 1 beta	Homo sapiens	162-171
7665990-4	1995	Ethanol-induced down-regulation of monocyte TNF-alpha, IL-1 beta, and IL-6 occurred at both the protein and mRNA levels.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	55-64
7564267-11	1995	A blocking Ab against the type I IL-1R completely inhibited, in both normal and OA cells, the receptor binding and IL-1 beta stimulated PGE2 production, whereas the treatment with anti-type II IL-1R was ineffective.	Dinoprostone	136-140	interleukin 1 beta	Homo sapiens	115-124
7665990-5	1995	Additional data suggest that ethanol can decrease IL-1 beta mRNA stability.	Ethanol	29-36	interleukin 1 beta	Homo sapiens	50-59
7665990-6	1995	Furthermore, experiments using cycloheximide indicate that de novo protein synthesis is required for the inhibitory effect of ethanol on SEB-induced IL-1 beta mRNA production.	Ethanol	126-133	interleukin 1 beta	Homo sapiens	149-158
29539800-2	1995	Interleukin-1beta (IL-1beta) mRNA was detected in freshly obtained cells by blot hybridization of total cellular RNA with a biotin labeled cDNA probe.	Biotin	124-130	interleukin 1 beta	Homo sapiens	0-17
29539800-2	1995	Interleukin-1beta (IL-1beta) mRNA was detected in freshly obtained cells by blot hybridization of total cellular RNA with a biotin labeled cDNA probe.	Biotin	124-130	interleukin 1 beta	Homo sapiens	19-27
29539800-4	1995	Significantly greater numbers of PMN and amounts of PMN-derived IL-1beta were obtained from the same donors 2 hours subsequent to an oral sucrose challenge (3.23 x 106 vs. 1.57 x 106 mean PMN number, P = 0.004; 59.80 vs. 20.05 mean pg/ml IL-1beta, P = 0.036, respectively).	Sucrose	138-145	interleukin 1 beta	Homo sapiens	64-72
7565623-3	1995	Lipopolysaccharide (LPS)-activated human monocytes treated with SKF86002 produced less proIL-1 beta but normal amounts of the noncytokine lysozyme.	6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole	64-72	interleukin 1 beta	Homo sapiens	87-99
7565623-9	1995	Moreover, LPS-activated monocytes that were pretreated with granulocyte-macrophage colony-stimulating factor were less sensitive to the proIL-1 beta inhibitory effect of SKF86002, and production of proIL-1 beta by cytokine-stimulated human fibroblasts was impaired only modestly by the CSAID.	csaid	286-291	interleukin 1 beta	Homo sapiens	198-210
7565623-10	1995	A second effect of SKF86002 was to inhibit release of IL-1 beta into the medium in response to high concentrations of LPS; this effect is observed only with freshly isolated human monocytes as other IL-1 beta-producing cells do not release significant cytokine in response to LPS.	6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole	19-27	interleukin 1 beta	Homo sapiens	54-63
7565623-10	1995	A second effect of SKF86002 was to inhibit release of IL-1 beta into the medium in response to high concentrations of LPS; this effect is observed only with freshly isolated human monocytes as other IL-1 beta-producing cells do not release significant cytokine in response to LPS.	6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole	19-27	interleukin 1 beta	Homo sapiens	199-208
7565623-13	1995	Thus, SKF86002 inhibits IL-1 beta production by affecting at least two distinct steps in the biosynthesis of this cytokine.	6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole	6-14	interleukin 1 beta	Homo sapiens	24-33
8748249-10	1995	IL-1 beta and IFN act directly and specifically on the glucose-sensitive neurons in the ventromedial hypothalamic nucleus (a "satiety" site) and the lateral hypothalamic area (a "hunger" site).	Glucose	55-62	interleukin 1 beta	Homo sapiens	0-9
21597830-2	1995	Incubation with 100 ng/ml human recombinant IL-1 beta for 20 hours prior to a one hour exposure to L-phenylalanine mustard (L-PAM) provided significant protection of bone marrow colony forming cells when compared to bone marrow cells not exposed to IL-1.	Melphalan	99-122	interleukin 1 beta	Homo sapiens	44-53
21597830-2	1995	Incubation with 100 ng/ml human recombinant IL-1 beta for 20 hours prior to a one hour exposure to L-phenylalanine mustard (L-PAM) provided significant protection of bone marrow colony forming cells when compared to bone marrow cells not exposed to IL-1.	Melphalan	124-129	interleukin 1 beta	Homo sapiens	44-53
7556162-8	1995	Poly (I).poly (C) induces VCAM-1 mRNA levels that are dramatically higher and sustained longer than levels induced by IL-1 beta.	Poly I	0-8	interleukin 1 beta	Homo sapiens	118-127
7474452-7	1995	Macrophages in vitro have a high capacity to synthesize QUIN following exposure to interferon-gamma, tumor necrosis factor-alpha, IL-1 beta and IL-6, compared to cells derived from other tissues.	Quinolinic Acid	56-60	interleukin 1 beta	Homo sapiens	130-139
7500241-2	1995	Interleukin-1 beta (IL-1 beta) mRNA was detected in freshly obtained cells by blot hybridization of total cellular RNA with a biotin labeled cDNA probe.	Biotin	126-132	interleukin 1 beta	Homo sapiens	0-18
7500241-2	1995	Interleukin-1 beta (IL-1 beta) mRNA was detected in freshly obtained cells by blot hybridization of total cellular RNA with a biotin labeled cDNA probe.	Biotin	126-132	interleukin 1 beta	Homo sapiens	20-29
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Staurosporine	13-26	interleukin 1 beta	Homo sapiens	194-212
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Staurosporine	13-26	interleukin 1 beta	Homo sapiens	214-223
7544008-0	1995	Interleukin 1 beta up-regulates the expression of sulfoglucuronosyl paragloboside, a ligand for L-selectin, in brain microvascular endothelial cells.	sulfate-3-glucuronyl paragloboside	50-81	interleukin 1 beta	Homo sapiens	0-18
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 beta	Homo sapiens	194-212
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 beta	Homo sapiens	214-223
7645620-2	1995	STUDY DESIGN: Secondary cultures of human umbilical vein endothelial cells were grown to confluence and treated with interleukin-1 beta, an array of factors with possible regulatory actions (cytokines, growth factors, vasoactive peptides, and steroids), and a phorbol ester as a stimulatory control.	Steroids	243-251	interleukin 1 beta	Homo sapiens	117-135
7499725-2	1995	administration of recombinant human interleukin-1 beta (rhIL-1 beta) and human interleukin-1 beta-fraction (hfrIL-1 beta) on the activity of vagal efferent fibers innervating the thymus were observed in urethane-anesthetized rats.	Urethane	203-211	interleukin 1 beta	Homo sapiens	36-54
7499725-2	1995	administration of recombinant human interleukin-1 beta (rhIL-1 beta) and human interleukin-1 beta-fraction (hfrIL-1 beta) on the activity of vagal efferent fibers innervating the thymus were observed in urethane-anesthetized rats.	Urethane	203-211	interleukin 1 beta	Homo sapiens	79-97
8526991-7	1995	Moreover, the expression of COX-2 mRNA in IL-1 beta-stimulated cells was superinduced by preincubation with cycloheximide, but completely abolished by actinomycin D.	Cycloheximide	108-121	interleukin 1 beta	Homo sapiens	42-51
8526991-7	1995	Moreover, the expression of COX-2 mRNA in IL-1 beta-stimulated cells was superinduced by preincubation with cycloheximide, but completely abolished by actinomycin D.	Dactinomycin	151-164	interleukin 1 beta	Homo sapiens	42-51
8526991-8	1995	CONCLUSIONS: Taken together, the data suggest that COX-2 mRNA expression is largely responsible for the robust increase in PG formation seen in IL-1 beta-treated decidual cells.	pg	123-125	interleukin 1 beta	Homo sapiens	144-153
7551660-6	1995	Decreases in circulating levels of sTNFR and in the in vitro production of cell-associated IL-1 beta and IL-1RA after stimulation were only observed in patients treated with MTX + SASP.	Methotrexate	174-177	interleukin 1 beta	Homo sapiens	91-100
7551660-9	1995	Decreased production of IL-1 beta and IL-1RA and circulating sTNFR levels were only observed during therapy with MTX + SASP.	Methotrexate	113-116	interleukin 1 beta	Homo sapiens	24-33
8526991-1	1995	PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2).	Dinoprostone	132-148	interleukin 1 beta	Homo sapiens	70-88
8526991-1	1995	PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2).	Dinoprostone	132-148	interleukin 1 beta	Homo sapiens	90-99
8526991-1	1995	PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2).	Dinoprostone	163-167	interleukin 1 beta	Homo sapiens	70-88
8526991-1	1995	PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2).	Dinoprostone	163-167	interleukin 1 beta	Homo sapiens	90-99
8526991-1	1995	PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2).	Dinoprost	172-176	interleukin 1 beta	Homo sapiens	70-88
8526991-1	1995	PROBLEM: The purpose of this study was to examine the hypothesis that interleukin-1 beta (IL-1 beta)-elicited increases in decidual prostaglandin E2 and F2 alpha (PGE2 and PGF2 alpha) biosynthesis are due to the de novo expression of the inducible isoform of cyclooxygenase (i.e., COX-2).	Dinoprost	172-176	interleukin 1 beta	Homo sapiens	90-99
8526991-4	1995	RESULTS: IL-1 beta stimulated a time-dependent enhancement in PGE2 and PGF2 alpha production, with PGF2 alpha synthesis predominating over PGE2.	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	9-18
8526991-4	1995	RESULTS: IL-1 beta stimulated a time-dependent enhancement in PGE2 and PGF2 alpha production, with PGF2 alpha synthesis predominating over PGE2.	Dinoprost	71-75	interleukin 1 beta	Homo sapiens	9-18
8526991-4	1995	RESULTS: IL-1 beta stimulated a time-dependent enhancement in PGE2 and PGF2 alpha production, with PGF2 alpha synthesis predominating over PGE2.	Dinoprost	99-103	interleukin 1 beta	Homo sapiens	9-18
8526991-4	1995	RESULTS: IL-1 beta stimulated a time-dependent enhancement in PGE2 and PGF2 alpha production, with PGF2 alpha synthesis predominating over PGE2.	Dinoprostone	139-143	interleukin 1 beta	Homo sapiens	9-18
8526991-5	1995	IL-1 beta also induced a dose-dependent increase in the output of both arachidonic acid metabolites.	Arachidonic Acid	71-87	interleukin 1 beta	Homo sapiens	0-9
8526991-6	1995	When Northern blots of IL-1 beta-treated and control cells were probed with cDNAs encoding either COX-1 or COX-2 isoforms or an oligonucleotide probe encoding a portion of the human beta-actin, we detected a time- and dose-dependent increase in the steady-state levels of COX-2, but not COX-1 or beta-actin mRNA transcripts.	Oligonucleotides	128-143	interleukin 1 beta	Homo sapiens	23-32
7645620-2	1995	STUDY DESIGN: Secondary cultures of human umbilical vein endothelial cells were grown to confluence and treated with interleukin-1 beta, an array of factors with possible regulatory actions (cytokines, growth factors, vasoactive peptides, and steroids), and a phorbol ester as a stimulatory control.	Phorbol Esters	260-273	interleukin 1 beta	Homo sapiens	117-135
7645620-7	1995	Interleukin-1 receptor antagonist, cycloheximide, and actinomycin D blocked the effects of interleukin-1 beta (p &lt; 0.05).	Cycloheximide	35-48	interleukin 1 beta	Homo sapiens	91-109
7645620-7	1995	Interleukin-1 receptor antagonist, cycloheximide, and actinomycin D blocked the effects of interleukin-1 beta (p &lt; 0.05).	Dactinomycin	54-67	interleukin 1 beta	Homo sapiens	91-109
7496871-6	1995	Addition of dexamethasone resulted in a reduction of TNF, IL-1 and IL-6 release to below background levels.	Dexamethasone	12-25	interleukin 1 beta	Homo sapiens	58-62
7496871-7	1995	Sulphapyridine significantly reduced TNF and induced IL-1 release in a dose-dependent fashion, but had no significant effect on IL-6 release.	Sulfapyridine	0-14	interleukin 1 beta	Homo sapiens	53-57
8580368-4	1995	Captopril dose-dependently suppressed the IL-1 beta-induced synthesis of TNF by 74% (P &lt; 0.01) and the IL-1 beta-induced synthesis of IL-1 alpha by 60% (P &lt; 0.01).	Captopril	0-9	interleukin 1 beta	Homo sapiens	42-51
7496871-8	1995	5-Aminosalicylic acid did not modulate IL-6 synthesis, but significantly reduced IL-1 and enhanced TNF synthesis.	Mesalamine	0-21	interleukin 1 beta	Homo sapiens	81-85
8580368-4	1995	Captopril dose-dependently suppressed the IL-1 beta-induced synthesis of TNF by 74% (P &lt; 0.01) and the IL-1 beta-induced synthesis of IL-1 alpha by 60% (P &lt; 0.01).	Captopril	0-9	interleukin 1 beta	Homo sapiens	106-115
7552951-6	1995	There were positive correlations between saline aspirate and joint fluid concentrations for NPY-LI and IL-1 beta, and the correlations were stronger for saline aspirates with high joint fluid content.	Sodium Chloride	41-47	interleukin 1 beta	Homo sapiens	103-112
7496871-9	1995	Zileuton reduced TNF and IL-6 release, but enhanced IL-1 release.	zileuton	0-8	interleukin 1 beta	Homo sapiens	52-56
7628398-0	1995	Blockade of nitric oxide formation augments adrenocorticotropin released by blood-borne interleukin-1 beta: role of vasopressin, prostaglandins, and alpha 1-adrenergic receptors.	Nitric Oxide	12-24	interleukin 1 beta	Homo sapiens	88-106
7628352-7	1995	IL-1 beta-induced AS and iNOS mRNA expression was prevented by an inhibitor of the activation factor NF-kappa B pyrrolidine diaminoguanidine, an inhibitor of gene transcription (actinomycin D), and a blocker of protein synthesis (cycloheximide), suggesting coregulation of AS and iNOS by cytokines.	pyrrolidine diaminoguanidine	112-140	interleukin 1 beta	Homo sapiens	0-9
7628352-7	1995	IL-1 beta-induced AS and iNOS mRNA expression was prevented by an inhibitor of the activation factor NF-kappa B pyrrolidine diaminoguanidine, an inhibitor of gene transcription (actinomycin D), and a blocker of protein synthesis (cycloheximide), suggesting coregulation of AS and iNOS by cytokines.	Dactinomycin	178-191	interleukin 1 beta	Homo sapiens	0-9
7628352-7	1995	IL-1 beta-induced AS and iNOS mRNA expression was prevented by an inhibitor of the activation factor NF-kappa B pyrrolidine diaminoguanidine, an inhibitor of gene transcription (actinomycin D), and a blocker of protein synthesis (cycloheximide), suggesting coregulation of AS and iNOS by cytokines.	Cycloheximide	230-243	interleukin 1 beta	Homo sapiens	0-9
7628352-8	1995	RIN cells exposed to IL-1 beta in the presence of citrulline but the absence of arginine had increased AS enzyme activity and produced NO, demonstrating that cytokine-induced AS mRNA expression is accompanied by increased AS activity.	Citrulline	50-60	interleukin 1 beta	Homo sapiens	21-30
7628352-9	1995	Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO.	Citrulline	170-180	interleukin 1 beta	Homo sapiens	99-108
7628352-9	1995	Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO.	Arginine	195-203	interleukin 1 beta	Homo sapiens	99-108
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	Nitric Oxide	12-24	interleukin 1 beta	Homo sapiens	186-204
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	Nitric Oxide	12-24	interleukin 1 beta	Homo sapiens	206-215
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	Arginine	49-57	interleukin 1 beta	Homo sapiens	186-204
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	Arginine	49-57	interleukin 1 beta	Homo sapiens	206-215
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	l-n omega nitro-l-arginine	69-95	interleukin 1 beta	Homo sapiens	186-204
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	l-n omega nitro-l-arginine	69-95	interleukin 1 beta	Homo sapiens	206-215
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	NG-Nitroarginine Methyl Ester	109-115	interleukin 1 beta	Homo sapiens	186-204
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	NG-Nitroarginine Methyl Ester	109-115	interleukin 1 beta	Homo sapiens	206-215
7628398-6	1995	Finally, as expected, blockade of PG synthesis with ibuprofen totally abolished IL-1 beta-induced ACTH secretion; in addition, it prevented the interaction between L-NAME and the pituitary response.	Prostaglandins	34-36	interleukin 1 beta	Homo sapiens	80-89
7628398-6	1995	Finally, as expected, blockade of PG synthesis with ibuprofen totally abolished IL-1 beta-induced ACTH secretion; in addition, it prevented the interaction between L-NAME and the pituitary response.	Ibuprofen	52-61	interleukin 1 beta	Homo sapiens	80-89
7635420-0	1995	Synthesis of interleukin-1 beta in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression.	Methotrexate	93-105	interleukin 1 beta	Homo sapiens	13-31
7622213-0	1995	Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1 beta secretion from human monocytes.	Polysaccharides	31-45	interleukin 1 beta	Homo sapiens	81-99
7635420-0	1995	Synthesis of interleukin-1 beta in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression.	Colchicine	109-119	interleukin 1 beta	Homo sapiens	13-31
7635420-10	1995	At 24 months, IL-2-induced IL-1 beta synthesis was increased in patients treated with methotrexate, whereas S epidermidis-induced IL-1 beta was enhanced in colchicine-treated patients.	Methotrexate	86-98	interleukin 1 beta	Homo sapiens	27-36
7635420-10	1995	At 24 months, IL-2-induced IL-1 beta synthesis was increased in patients treated with methotrexate, whereas S epidermidis-induced IL-1 beta was enhanced in colchicine-treated patients.	Colchicine	156-166	interleukin 1 beta	Homo sapiens	130-139
8576539-9	1995	IL-1 beta production in cultures of human peripheral blood monocytes was significantly decreased after exposure of the cultures to varying doses of amiprilose HCl as determined by ELISA.	amiprilose	148-162	interleukin 1 beta	Homo sapiens	0-9
7543498-2	1995	Extremely low, prophylactic, concentrations of colchicine (IC50 = 3 nM) eliminated the E-selectin-mediated increment in endothelial adhesiveness for neutrophils in response to IL-1 (P &lt; 0.001) or TNF alpha (P &lt; 0.001) by changing the distribution, but not the number, of E-selectin molecules on the surface of the endothelial cells.	Colchicine	47-57	interleukin 1 beta	Homo sapiens	176-180
7629246-7	1995	Treatment of PBMCs with 10 nmol/L 17 beta-estradiol in vitro significantly stimulated IL-1 beta production in both groups.	Estradiol	34-51	interleukin 1 beta	Homo sapiens	86-95
7629516-1	1995	We previously reported that ceramide, the immediate product of sphingomyelin hydrolysis, increases in response to interleukin (IL)-1 beta and plays a role in modulating IL-1 beta-mediated prostaglandin E2 production and cyclooxygenase gene expression in human fibroblasts (Ballou, L. R., C. P. Chao, M. A. Holness, S. C. Barker, and R. Raghow.	Ceramides	28-36	interleukin 1 beta	Homo sapiens	114-137
7629516-1	1995	We previously reported that ceramide, the immediate product of sphingomyelin hydrolysis, increases in response to interleukin (IL)-1 beta and plays a role in modulating IL-1 beta-mediated prostaglandin E2 production and cyclooxygenase gene expression in human fibroblasts (Ballou, L. R., C. P. Chao, M. A. Holness, S. C. Barker, and R. Raghow.	Ceramides	28-36	interleukin 1 beta	Homo sapiens	169-178
7629516-1	1995	We previously reported that ceramide, the immediate product of sphingomyelin hydrolysis, increases in response to interleukin (IL)-1 beta and plays a role in modulating IL-1 beta-mediated prostaglandin E2 production and cyclooxygenase gene expression in human fibroblasts (Ballou, L. R., C. P. Chao, M. A. Holness, S. C. Barker, and R. Raghow.	Sphingomyelins	63-76	interleukin 1 beta	Homo sapiens	114-137
7629516-1	1995	We previously reported that ceramide, the immediate product of sphingomyelin hydrolysis, increases in response to interleukin (IL)-1 beta and plays a role in modulating IL-1 beta-mediated prostaglandin E2 production and cyclooxygenase gene expression in human fibroblasts (Ballou, L. R., C. P. Chao, M. A. Holness, S. C. Barker, and R. Raghow.	Dinoprostone	188-204	interleukin 1 beta	Homo sapiens	169-178
7629516-6	1995	Here we describe the effects of ceramide in another IL-1 beta-mediated process in these cells, the induction of IL-6 production.	Ceramides	32-40	interleukin 1 beta	Homo sapiens	52-61
7629516-9	1995	Compared with IL-1 beta-induced IL-6 production, cells treated with ceramide or exogenous sphingomyelinase induced 82 and 50% of maximal IL-1 beta-induced IL-6 levels by 6 h, respectively; by 24 h all three treatments induced similar levels of IL-6 production.	Ceramides	68-76	interleukin 1 beta	Homo sapiens	137-146
7477764-3	1995	LPS in concentration 1.5 micrograms/ml stimulated PBM to release IL-1 beta or IL-6 into the supernatants.	pbm	50-53	interleukin 1 beta	Homo sapiens	65-74
7629057-4	1995	However, Fit-1S binds IL-1 beta only with low affinity in contrast to the IL-1 receptor, suggesting that IL-1 beta is not a physiological ligand of Fit-1S.	fit-1s	9-15	interleukin 1 beta	Homo sapiens	22-31
7615528-3	1995	IL-1 beta increased the formation of all octadecanoids in a time- and dose-dependent manner with similar EC50 (approximately 1 unit/ml).	octadecanoids	41-54	interleukin 1 beta	Homo sapiens	0-9
7615528-4	1995	The apparent Km values of linoleic acid were 15.59 +/- 8.39 and 152.9 +/- 84 microM (p &lt; 0.05) in IL-1 beta-treated cells and controls, respectively, indicating a higher substrate affinity in cells stimulated with IL-1 beta.	Linoleic Acid	26-39	interleukin 1 beta	Homo sapiens	101-110
7615528-4	1995	The apparent Km values of linoleic acid were 15.59 +/- 8.39 and 152.9 +/- 84 microM (p &lt; 0.05) in IL-1 beta-treated cells and controls, respectively, indicating a higher substrate affinity in cells stimulated with IL-1 beta.	Linoleic Acid	26-39	interleukin 1 beta	Homo sapiens	217-226
7615528-5	1995	Ratios of S/R enantiomers for the hydroxyoctadecanoids produced by untreated and IL-1 beta-treated cells were similar to those from isolated cyclooxygenases (COXs), whereas isolated 15-lipoxygenase yielded 13-HODE with a strict S configuration.	hydroxyoctadecanoids	34-54	interleukin 1 beta	Homo sapiens	81-90
7615528-6	1995	The formation of octadecanoids was inhibited in a dose-dependent manner by several COX inhibitors in both controls and IL-1 beta-treated cells, COX2 selective inhibitors being more effective on IL-1 beta-treated cells than on controls.	octadecanoids	17-30	interleukin 1 beta	Homo sapiens	119-128
7626041-3	1995	The response to forskolin, a direct stimulus of adenylyl cyclase, was also significantly enhanced, indicating that the effect of interleukin-1 beta was targeted to the enzyme itself.	Colforsin	16-25	interleukin 1 beta	Homo sapiens	129-147
7626041-4	1995	This action of interleukin-1 beta was blocked by co-incubation with cycloheximide, an inhibitor of protein synthesis, which demonstrated that de novo protein synthesis was required.	Cycloheximide	68-81	interleukin 1 beta	Homo sapiens	15-33
7615528-6	1995	The formation of octadecanoids was inhibited in a dose-dependent manner by several COX inhibitors in both controls and IL-1 beta-treated cells, COX2 selective inhibitors being more effective on IL-1 beta-treated cells than on controls.	octadecanoids	17-30	interleukin 1 beta	Homo sapiens	194-203
7615528-9	1995	Overall, these results indicate that COXs are responsible for the oxidative metabolism of linoleic acid in HUVEC, and IL-1 beta increases it by inducing the expression of new enzyme, mainly COX2.	Linoleic Acid	90-103	interleukin 1 beta	Homo sapiens	118-127
7608561-0	1995	A cyclic adenosine 3",5"-monophosphate signal is required for the induction of IL-1 beta by TNF-alpha in human monocytes.	Cyclic AMP	2-38	interleukin 1 beta	Homo sapiens	79-88
7608561-4	1995	This TNF-alpha/cAMP pathway regulates IL-1 beta production at the level of transcription and requires a cAMP response element located between -2762 and -2755 bp in the upstream regulatory sequence of IL-1 beta.	Cyclic AMP	15-19	interleukin 1 beta	Homo sapiens	38-47
7608561-4	1995	This TNF-alpha/cAMP pathway regulates IL-1 beta production at the level of transcription and requires a cAMP response element located between -2762 and -2755 bp in the upstream regulatory sequence of IL-1 beta.	Cyclic AMP	15-19	interleukin 1 beta	Homo sapiens	200-209
7608561-4	1995	This TNF-alpha/cAMP pathway regulates IL-1 beta production at the level of transcription and requires a cAMP response element located between -2762 and -2755 bp in the upstream regulatory sequence of IL-1 beta.	Cyclic AMP	104-108	interleukin 1 beta	Homo sapiens	38-47
7608561-4	1995	This TNF-alpha/cAMP pathway regulates IL-1 beta production at the level of transcription and requires a cAMP response element located between -2762 and -2755 bp in the upstream regulatory sequence of IL-1 beta.	Cyclic AMP	104-108	interleukin 1 beta	Homo sapiens	200-209
7608561-5	1995	Because PG, which are known to elevate cAMP levels in vivo, and TNF-alpha are both found in significant quantities in the synovial fluid of rheumatoid arthritis joints, the observed synergistic up-regulation in IL-1 beta synthesis by TNF-alpha/cAMP (PG) may provide valuable insight into the potential pathways involved in the continuous production of IL-1 beta in the chronically inflamed joint.	Cyclic AMP	244-248	interleukin 1 beta	Homo sapiens	211-220
7608561-5	1995	Because PG, which are known to elevate cAMP levels in vivo, and TNF-alpha are both found in significant quantities in the synovial fluid of rheumatoid arthritis joints, the observed synergistic up-regulation in IL-1 beta synthesis by TNF-alpha/cAMP (PG) may provide valuable insight into the potential pathways involved in the continuous production of IL-1 beta in the chronically inflamed joint.	pg	8-10	interleukin 1 beta	Homo sapiens	211-220
7608561-5	1995	Because PG, which are known to elevate cAMP levels in vivo, and TNF-alpha are both found in significant quantities in the synovial fluid of rheumatoid arthritis joints, the observed synergistic up-regulation in IL-1 beta synthesis by TNF-alpha/cAMP (PG) may provide valuable insight into the potential pathways involved in the continuous production of IL-1 beta in the chronically inflamed joint.	pg	8-10	interleukin 1 beta	Homo sapiens	352-361
7541794-5	1995	The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.	Genistein	31-40	interleukin 1 beta	Homo sapiens	129-138
7541794-5	1995	The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.	herbimycin	45-57	interleukin 1 beta	Homo sapiens	129-138
7541794-5	1995	The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.	Tyrosine	4-12	interleukin 1 beta	Homo sapiens	129-138
7670776-7	1995	Pretreatment determination of the IL-1ra:IL-1 beta ratio in PBMC may be predictive with regard to a favourable therapeutic response and therefore may be useful for the selection of RA patients to be treated with MTX.	Methotrexate	212-215	interleukin 1 beta	Homo sapiens	41-50
7601250-1	1995	Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner.	Superoxides	118-120	interleukin 1 beta	Homo sapiens	47-56
7607324-0	1995	Ceramide inhibits pancreatic beta-cell insulin production and mitogenesis and mimics the actions of interleukin-1 beta.	Ceramides	0-8	interleukin 1 beta	Homo sapiens	100-118
7607324-3	1995	Generation of beta-cell ceramide by exogenous sphingomyelinase, or addition of cell-permeant ceramide analogs C2-ceramide and C6-ceramide, caused inhibitor effects on beta-cell insulin production and mitogenesis mimicing those evoked by IL-1 beta.	beta-cell ceramide	14-32	interleukin 1 beta	Homo sapiens	237-246
7607324-3	1995	Generation of beta-cell ceramide by exogenous sphingomyelinase, or addition of cell-permeant ceramide analogs C2-ceramide and C6-ceramide, caused inhibitor effects on beta-cell insulin production and mitogenesis mimicing those evoked by IL-1 beta.	Ceramides	24-32	interleukin 1 beta	Homo sapiens	237-246
7607324-4	1995	Hence, ceramide may be involved in transducing the cytostatic and cytotoxic actions of IL-1 beta in the beta-cell.	Ceramides	7-15	interleukin 1 beta	Homo sapiens	87-96
7601250-1	1995	Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner.	Superoxides	106-116	interleukin 1 beta	Homo sapiens	47-56
7601250-1	1995	Together, interleukin-1 alpha (IL-1 alpha) and IL-1 beta primed human neutrophils for enhanced release of superoxide (O2-) stimulated by chemotactic peptide, chemokine, and plant lectin, and alone, each triggered O2- release in a dose-dependent manner.	Superoxides	213-215	interleukin 1 beta	Homo sapiens	47-56
7621072-5	1995	The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha).	Nitrites	204-211	interleukin 1 beta	Homo sapiens	263-272
21552804-2	1995	We report that all-trans retinoic acid (tRA) synergizes with LPS to enhance the production of granulocyte colony-stimulating factor (G-CSF) in PMA-treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA.	Tretinoin	25-38	interleukin 1 beta	Homo sapiens	216-234
8530147-0	1995	Regulation of IL-1 beta expression by cyclic AMP in myeloid cells.	Cyclic AMP	38-48	interleukin 1 beta	Homo sapiens	14-23
21552804-2	1995	We report that all-trans retinoic acid (tRA) synergizes with LPS to enhance the production of granulocyte colony-stimulating factor (G-CSF) in PMA-treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA.	Tretinoin	25-38	interleukin 1 beta	Homo sapiens	236-245
21552804-2	1995	We report that all-trans retinoic acid (tRA) synergizes with LPS to enhance the production of granulocyte colony-stimulating factor (G-CSF) in PMA-treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA.	Tretinoin	40-43	interleukin 1 beta	Homo sapiens	216-234
21552804-2	1995	We report that all-trans retinoic acid (tRA) synergizes with LPS to enhance the production of granulocyte colony-stimulating factor (G-CSF) in PMA-treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA.	Tretinoin	40-43	interleukin 1 beta	Homo sapiens	236-245
7593467-4	1995	Dexamethasone-mediated inhibition of induction of interleukin-1 beta mRNA by lipopolysaccharide required a functional glucocorticoid receptor.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	50-68
7593467-7	1995	U-373MG cells were similar to monocytes, however, with respect to the ability of dexamethasone to decrease interleukin-1 beta mRNA half-life.	Dexamethasone	81-94	interleukin 1 beta	Homo sapiens	107-125
7593467-0	1995	Protein synthesis-dependent induction of interleukin-1 beta by lipopolysaccharide is inhibited by dexamethasone via mRNA destabilization in human astroglial cells.	Dexamethasone	98-111	interleukin 1 beta	Homo sapiens	41-59
7593467-1	1995	Dexamethasone inhibits lipopolysaccharide-induced synthesis of the cytokine, interleukin-1 beta, in cerebrospinal fluid of patients with bacterial meningitis.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	77-95
7637187-6	1995	We concluded that isoflurane could inhibit TNF-alpha and IL-1 beta secretions from peripheral blood monocytes stimulated by LPS in a dose-dependent fashion and that the inhibitory action of isoflurane was reversible.	Isoflurane	18-28	interleukin 1 beta	Homo sapiens	57-66
7615820-6	1995	Reducing the concentration of tryptophan from 25 microM to 0 markedly diminished the ability of fibroblasts to increase collagenase and stromelysin mRNA and collagenase production in response to IL-1 beta.	Tryptophan	30-40	interleukin 1 beta	Homo sapiens	195-204
7615820-7	1995	Addition of exogenous tryptophan (25-50 micrograms/ml) to cultures that had been tryptophan depleted by pretreatment with IFN-gamma for 48 h restored the fibroblast response to IL-1 beta or PMA, but had no effect on IFN-gamma-induced HLA-DR alpha chain mRNA expression.	Tryptophan	22-32	interleukin 1 beta	Homo sapiens	177-186
7637187-0	1995	[The effect of isoflurane on the secretion of TNF-alpha and IL-1 beta from LPS-stimulated human peripheral blood monocytes].	Isoflurane	15-25	interleukin 1 beta	Homo sapiens	60-69
7556406-1	1995	The inhibitory mechanism of gastric acid secretion induced by human recombinant interleukin-1 beta was investigated in bilaterally vagotomized, urethane-anesthetized rats.	Urethane	144-152	interleukin 1 beta	Homo sapiens	80-98
7637187-4	1995	TNF-alpha and IL-1 beta secretions increased after LPS stimulation and this increase was inhibited by isoflurane in dose-dependent fashion.	Isoflurane	102-112	interleukin 1 beta	Homo sapiens	14-23
7631148-4	1995	After treatment with the phorbol ester TPA or the calcium ionophore ionomycin expression of several cytokines, i.e. IL-1 beta, IL-3, IL-6, GM-CSF, TNF-beta and PDGF-A, could be detected.	Ionomycin	68-77	interleukin 1 beta	Homo sapiens	116-125
7540991-0	1995	N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells.	N,N,N-trimethylsphingosine	0-26	interleukin 1 beta	Homo sapiens	36-54
7540991-1	1995	We examined the effect of N,N,N-trimethylsphingosine (TMS) on the interleukin-1 beta (IL-1 beta)-induced E-selectin expression in human umbilical vein endothelial cells (HUVEC).	N,N,N-trimethylsphingosine	26-52	interleukin 1 beta	Homo sapiens	66-84
7540991-1	1995	We examined the effect of N,N,N-trimethylsphingosine (TMS) on the interleukin-1 beta (IL-1 beta)-induced E-selectin expression in human umbilical vein endothelial cells (HUVEC).	N,N,N-trimethylsphingosine	26-52	interleukin 1 beta	Homo sapiens	86-95
7540991-1	1995	We examined the effect of N,N,N-trimethylsphingosine (TMS) on the interleukin-1 beta (IL-1 beta)-induced E-selectin expression in human umbilical vein endothelial cells (HUVEC).	N,N,N-trimethylsphingosine	54-57	interleukin 1 beta	Homo sapiens	66-84
7540991-1	1995	We examined the effect of N,N,N-trimethylsphingosine (TMS) on the interleukin-1 beta (IL-1 beta)-induced E-selectin expression in human umbilical vein endothelial cells (HUVEC).	N,N,N-trimethylsphingosine	54-57	interleukin 1 beta	Homo sapiens	86-95
7541949-8	1995	The cilia stimulatory effects of TNF-alpha or IL-1 beta were inhibited by NG-monomethyl-L-arginine, a competitive NOS inhibitor, and restored by the addition of either L-arginine, an NOS substrate, or sodium nitroprusside, an NO donor.	omega-N-Methylarginine	74-98	interleukin 1 beta	Homo sapiens	46-55
7541949-8	1995	The cilia stimulatory effects of TNF-alpha or IL-1 beta were inhibited by NG-monomethyl-L-arginine, a competitive NOS inhibitor, and restored by the addition of either L-arginine, an NOS substrate, or sodium nitroprusside, an NO donor.	Arginine	88-98	interleukin 1 beta	Homo sapiens	46-55
7541949-8	1995	The cilia stimulatory effects of TNF-alpha or IL-1 beta were inhibited by NG-monomethyl-L-arginine, a competitive NOS inhibitor, and restored by the addition of either L-arginine, an NOS substrate, or sodium nitroprusside, an NO donor.	Nitroprusside	201-221	interleukin 1 beta	Homo sapiens	46-55
7582449-8	1995	In experiments designed to measure "COX activity", 6-oxo-PGF1 alpha generated by BAEC activated with recombinant human IL-1 beta, TNF-alpha, EGF or PDGF for 12 h was measured after incubation of washed cells with exogenous arachidonic acid (30 microM for 15 min).	androst-4-ene-3,6,17-trione	51-56	interleukin 1 beta	Homo sapiens	119-128
7582449-8	1995	In experiments designed to measure "COX activity", 6-oxo-PGF1 alpha generated by BAEC activated with recombinant human IL-1 beta, TNF-alpha, EGF or PDGF for 12 h was measured after incubation of washed cells with exogenous arachidonic acid (30 microM for 15 min).	baec	81-85	interleukin 1 beta	Homo sapiens	119-128
7572276-5	1995	A possible role for this glial-derived IL-1 beta as an astroglial growth factor was substantiated by experiments showing that the lymphokine increased the incorporation of [3H]thymidine into astroglial, but not microglial cultures.	3h]thymidine	173-185	interleukin 1 beta	Homo sapiens	39-48
7582491-14	1995	These data suggest that IL-10 limits the inflammatory hyperalgesia evoked by carrageenin and bradykinin by two mechanisms: inhibition of cytokine production and inhibition of IL-1 beta evoked PGE2 production.	Dinoprostone	192-196	interleukin 1 beta	Homo sapiens	175-184
7614991-7	1995	Membrane-associated IL-1 activity, analyzed using glutaraldehyde-fixed EC, was low and not unique to PP EC.	Glutaral	50-64	interleukin 1 beta	Homo sapiens	20-24
7614991-8	1995	The cytosol of PP EC contained significantly increased levels of immunoreactive IL-1 beta.	pp ec	15-20	interleukin 1 beta	Homo sapiens	80-89
7614991-12	1995	Our observations show that resident PP EC express enhanced IL-1 production ex vivo, which is due to an increased cytosolic IL-1 beta content and facilitated IL-1 release.	pp ec	36-41	interleukin 1 beta	Homo sapiens	59-63
7614991-12	1995	Our observations show that resident PP EC express enhanced IL-1 production ex vivo, which is due to an increased cytosolic IL-1 beta content and facilitated IL-1 release.	pp ec	36-41	interleukin 1 beta	Homo sapiens	123-132
7614991-12	1995	Our observations show that resident PP EC express enhanced IL-1 production ex vivo, which is due to an increased cytosolic IL-1 beta content and facilitated IL-1 release.	pp ec	36-41	interleukin 1 beta	Homo sapiens	123-127
7614991-13	1995	This study provides the first evidence that PP EC can produce bioactive IL-1 beta.	pp ec	44-49	interleukin 1 beta	Homo sapiens	72-81
7560228-11	1995	In cell culture experiments, it was found that triclosan inhibited IL-1 beta induced prostaglandin E2 production by human gingival fibroblasts in a concentration dependent manner, and at relatively low concentrations.	Triclosan	47-56	interleukin 1 beta	Homo sapiens	67-76
7560228-11	1995	In cell culture experiments, it was found that triclosan inhibited IL-1 beta induced prostaglandin E2 production by human gingival fibroblasts in a concentration dependent manner, and at relatively low concentrations.	Dinoprostone	85-101	interleukin 1 beta	Homo sapiens	67-76
7769317-0	1995	Tumor necrosis factor-alpha and interleukin-1 beta in cerebrospinal fluid of patients with coccidioidal meningitis during therapy with fluconazole.	Fluconazole	135-146	interleukin 1 beta	Homo sapiens	32-50
7769093-5	1995	Studies on ET-1-induced intracellular signaling events in IL-1 beta-treated cells revealed that the failure of ET-1 to induce mitogenic responses was due to an increase in cAMP formation secondary to ET-1-induced activation of prostanoid metabolism.	Cyclic AMP	172-176	interleukin 1 beta	Homo sapiens	58-67
7769093-5	1995	Studies on ET-1-induced intracellular signaling events in IL-1 beta-treated cells revealed that the failure of ET-1 to induce mitogenic responses was due to an increase in cAMP formation secondary to ET-1-induced activation of prostanoid metabolism.	Prostaglandins	227-237	interleukin 1 beta	Homo sapiens	58-67
7651754-5	1995	In the present study we tested the 30- and 120-min effect of intraperitoneally administered 0.5 and 100 ng/g body weight IL-1 beta on the plasma immunoreactive (ir) ACTH, beta E, and corticosterone (CS) levels in the 10-d-old (infant) and 30-d-old (prepubertal) rat.	Corticosterone	183-197	interleukin 1 beta	Homo sapiens	121-130
7480804-0	1995	Interleukin-1 beta induces the synthesis and activity of cytosolic phospholipase A2 and the release of prostaglandin E2 in human amnion-derived WISH cells.	Dinoprostone	103-119	interleukin 1 beta	Homo sapiens	0-18
7480804-3	1995	Treatment of WISH cells with IL-1 beta (0.01-1 ng/mL) for up to 24 h resulted in a significant increase in PGE2 release in a concentration- and time-dependent manner accompanied by increases both in total cellular cPLA2 activity and in cPLA2 protein levels detected by Western blot analysis.	Dinoprostone	107-111	interleukin 1 beta	Homo sapiens	29-38
7480804-5	1995	Incubation of the cells with 10 microM AACOCF3 for 24 h significantly inhibited IL-1 beta-induced PGE2 production strongly suggesting that cPLA2 mediates IL-1 beta-induced PGE2 formation.	Dinoprostone	98-102	interleukin 1 beta	Homo sapiens	80-89
7480804-5	1995	Incubation of the cells with 10 microM AACOCF3 for 24 h significantly inhibited IL-1 beta-induced PGE2 production strongly suggesting that cPLA2 mediates IL-1 beta-induced PGE2 formation.	Dinoprostone	172-176	interleukin 1 beta	Homo sapiens	80-89
7480804-5	1995	Incubation of the cells with 10 microM AACOCF3 for 24 h significantly inhibited IL-1 beta-induced PGE2 production strongly suggesting that cPLA2 mediates IL-1 beta-induced PGE2 formation.	Dinoprostone	172-176	interleukin 1 beta	Homo sapiens	154-163
7480804-7	1995	In contrast to IL-1 beta, treatment with phorbol ester (12-O-tetradecanoyl phorbol-13-acetate, TPA, 10(-10)-10(-6)M) for 24 h significantly inhibited total cellular cPLA2 activity in a concentration-dependent manner.	Phorbol Esters	41-54	interleukin 1 beta	Homo sapiens	15-24
7480804-9	1995	These data suggest that in WISH cells, IL-1 beta induces both translocation to the membrane and de novo synthesis of cPLA2 protein to sustain prostaglandin (PG) synthesis.	Prostaglandins	142-155	interleukin 1 beta	Homo sapiens	39-48
7480804-9	1995	These data suggest that in WISH cells, IL-1 beta induces both translocation to the membrane and de novo synthesis of cPLA2 protein to sustain prostaglandin (PG) synthesis.	Prostaglandins	157-159	interleukin 1 beta	Homo sapiens	39-48
7480804-11	1995	Our results provide a mechanism for the effect of IL-1 beta on prostaglandin synthesis in human amnion cells and provide support for a role of cPLA2 in the mechanism initiating human parturition.	Prostaglandins	63-76	interleukin 1 beta	Homo sapiens	50-59
7540334-3	1995	Fresh human blood monocytes were exposed to 0.001-10 microM hydroquinone (HQ) and assessed for their ability to release IL-1 alpha and IL-1 beta in response to a stimulation with endotoxin.	hydroquinone	60-72	interleukin 1 beta	Homo sapiens	135-144
7786295-4	1995	This report shows that, in vitro, curcumin, at 5 microM, inhibited lipopolysaccharide (LPS)-induced production of TNF and IL-1 by a human monocytic macrophage cell line, Mono Mac 6.	Curcumin	34-42	interleukin 1 beta	Homo sapiens	122-126
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	41-68	interleukin 1 beta	Homo sapiens	237-246
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	70-74	interleukin 1 beta	Homo sapiens	237-246
7539260-2	1995	PDTC decreased by 90% both IL-1 beta-induced increase in medium nitrite accumulation (an indicator of NO production) and induction of iNOS mRNA expression.	Nitrites	64-71	interleukin 1 beta	Homo sapiens	27-36
7645988-1	1995	(-) Epigallocatechin gallate (EGCg) potently stimulated the production of interleukin-1 (IL-1) and tumor necrosis factor by human peripheral blood mononuclear cells.	epigallocatechin gallate	0-28	interleukin 1 beta	Homo sapiens	74-94
7597432-13	1995	When monocytes were stimulated with endotoxin, IL-1 beta production was greatest at 48 hours, suggesting that paclitaxel can prime cells to produce greater quantities of cytokines after a second stimulus.	Paclitaxel	110-120	interleukin 1 beta	Homo sapiens	47-56
7537968-9	1995	Supernatant from cells stimulated with TNF alpha and IL-1 beta increased eosinophil chemotaxis and this was also inhibited by dexamethasone.	Dexamethasone	126-139	interleukin 1 beta	Homo sapiens	53-62
7645988-1	1995	(-) Epigallocatechin gallate (EGCg) potently stimulated the production of interleukin-1 (IL-1) and tumor necrosis factor by human peripheral blood mononuclear cells.	epigallocatechin gallate	30-34	interleukin 1 beta	Homo sapiens	74-94
7645988-2	1995	The intracellular amounts of IL-1 beta and especially IL-1 alpha induced by EGCg, were significantly higher than their extracellular counterparts.	epigallocatechin gallate	76-80	interleukin 1 beta	Homo sapiens	29-38
7545487-3	1995	In contrast, both CsA and FK506 enhanced transforming growth factor beta (TGF beta) and IL-1 beta mRNA expression.	Cyclosporine	18-21	interleukin 1 beta	Homo sapiens	88-97
7748222-6	1995	RESULTS: Hyaluronan synthesis was stimulated in synovial lining cells by transforming growth factor beta 1 (TGF beta 1), interleukin-1 beta (IL-1 beta), and to a lesser extent by tumor necrosis factor alpha (TNF alpha).	Hyaluronic Acid	9-19	interleukin 1 beta	Homo sapiens	121-139
7748222-6	1995	RESULTS: Hyaluronan synthesis was stimulated in synovial lining cells by transforming growth factor beta 1 (TGF beta 1), interleukin-1 beta (IL-1 beta), and to a lesser extent by tumor necrosis factor alpha (TNF alpha).	Hyaluronic Acid	9-19	interleukin 1 beta	Homo sapiens	141-150
7748222-7	1995	Analysis of the molecular weight distribution of hyaluronan after stimulation of synovial lining cells with TGF beta 1, IL-1 beta, and TNF alpha indicated that hyaluronan is synthesized in a high molecular weight form and might be degraded in the course of inflammatory processes by oxygen-derived free radicals.	Hyaluronic Acid	49-59	interleukin 1 beta	Homo sapiens	120-129
7748222-7	1995	Analysis of the molecular weight distribution of hyaluronan after stimulation of synovial lining cells with TGF beta 1, IL-1 beta, and TNF alpha indicated that hyaluronan is synthesized in a high molecular weight form and might be degraded in the course of inflammatory processes by oxygen-derived free radicals.	Hyaluronic Acid	160-170	interleukin 1 beta	Homo sapiens	120-129
7545487-3	1995	In contrast, both CsA and FK506 enhanced transforming growth factor beta (TGF beta) and IL-1 beta mRNA expression.	Tacrolimus	26-31	interleukin 1 beta	Homo sapiens	88-97
8589264-9	1995	However, IL-1 beta was still able to decrease triglyceride synthesis in the presence of indomethacin.	Triglycerides	46-58	interleukin 1 beta	Homo sapiens	9-18
8589264-9	1995	However, IL-1 beta was still able to decrease triglyceride synthesis in the presence of indomethacin.	Indomethacin	88-100	interleukin 1 beta	Homo sapiens	9-18
8589264-5	1995	These metabolic studies showed that IL-1 beta inhibited the incorporation of label into triglycerides.	Triglycerides	88-101	interleukin 1 beta	Homo sapiens	36-45
8589264-10	1995	These results indicate that a prostaglandin-dependent increase in cAMP is important to in the lipolytic effects of IL-1 beta but that the anti-lipogenic effects of the cytokine are, at least in part, independent of PG synthesis.	Prostaglandins	30-43	interleukin 1 beta	Homo sapiens	115-124
8589264-8	1995	Forskolin (an adenylate cyclase activator) produced lipolytic effect similar to those of IL-1 beta, while indomethacin (an inhibitor of prostaglandin [PG] production) fully blocked the release of radioactivity induced by IL-1 beta and greatly increased triglyceride synthesis.	Colforsin	0-9	interleukin 1 beta	Homo sapiens	221-230
8589264-8	1995	Forskolin (an adenylate cyclase activator) produced lipolytic effect similar to those of IL-1 beta, while indomethacin (an inhibitor of prostaglandin [PG] production) fully blocked the release of radioactivity induced by IL-1 beta and greatly increased triglyceride synthesis.	Indomethacin	106-118	interleukin 1 beta	Homo sapiens	221-230
8589264-10	1995	These results indicate that a prostaglandin-dependent increase in cAMP is important to in the lipolytic effects of IL-1 beta but that the anti-lipogenic effects of the cytokine are, at least in part, independent of PG synthesis.	Cyclic AMP	66-70	interleukin 1 beta	Homo sapiens	115-124
7537695-0	1995	IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2.	Nitric Oxide	13-25	interleukin 1 beta	Homo sapiens	0-4
8589272-2	1995	Upon granulocytic differentiation with all-trans retinoic acid (ATRA) or the combination of ATRA and granulocyte-colony-stimulating factor (G-CSF), significant amounts of IL-1 beta and IL-8 mRNAs accumulated in both cell types.	2-octenal	43-48	interleukin 1 beta	Homo sapiens	171-180
8589272-2	1995	Upon granulocytic differentiation with all-trans retinoic acid (ATRA) or the combination of ATRA and granulocyte-colony-stimulating factor (G-CSF), significant amounts of IL-1 beta and IL-8 mRNAs accumulated in both cell types.	Tretinoin	49-62	interleukin 1 beta	Homo sapiens	171-180
7537695-0	1995	IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2.	Dinoprostone	65-69	interleukin 1 beta	Homo sapiens	0-4
8589272-2	1995	Upon granulocytic differentiation with all-trans retinoic acid (ATRA) or the combination of ATRA and granulocyte-colony-stimulating factor (G-CSF), significant amounts of IL-1 beta and IL-8 mRNAs accumulated in both cell types.	Tretinoin	64-68	interleukin 1 beta	Homo sapiens	171-180
7537695-2	1995	This study analyzed the role of nitric oxide (NO), which is induced at high levels by IL-1 in chondrocytes.	Nitric Oxide	32-44	interleukin 1 beta	Homo sapiens	86-90
7537695-4	1995	To determine whether IL-1-induced NO is responsible for growth inhibition by IL-1, chondrocytes were cultured in the presence of the nitric oxide synthase inhibitor N-monomethyl-L-arginine (NMA), which dose-dependently reduced the antiproliferative effects of IL-1.	omega-N-Methylarginine	165-188	interleukin 1 beta	Homo sapiens	21-25
7537695-4	1995	To determine whether IL-1-induced NO is responsible for growth inhibition by IL-1, chondrocytes were cultured in the presence of the nitric oxide synthase inhibitor N-monomethyl-L-arginine (NMA), which dose-dependently reduced the antiproliferative effects of IL-1.	omega-N-Methylarginine	165-188	interleukin 1 beta	Homo sapiens	77-81
7537695-4	1995	To determine whether IL-1-induced NO is responsible for growth inhibition by IL-1, chondrocytes were cultured in the presence of the nitric oxide synthase inhibitor N-monomethyl-L-arginine (NMA), which dose-dependently reduced the antiproliferative effects of IL-1.	omega-N-Methylarginine	165-188	interleukin 1 beta	Homo sapiens	77-81
7537695-6	1995	However, SNP induced high levels of PGE2, and NMA reduced IL-1-induced PGE2.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	58-62
7537695-9	1995	These results suggest that the chondrocyte growth inhibition by IL-1 in chondrocytes is due to the induction of NO, which stimulates the production of PGE2 as a mediator of its antiproliferative effects.	Dinoprostone	151-155	interleukin 1 beta	Homo sapiens	64-68
7745015-5	1995	Both IFN gamma and IL-1 beta inhibited [3H]thymidine incorporation into TP cells in a dose-dependent manner and decreased TP cell number.	Tritium	40-42	interleukin 1 beta	Homo sapiens	19-28
7722467-4	1995	ICE and granzyme B share the rare substrate site of aspartic acid, after which amino acid cleavage of precursor IL-1 beta (pIL-1 beta) occurs.	Aspartic Acid	52-65	interleukin 1 beta	Homo sapiens	112-121
7745015-5	1995	Both IFN gamma and IL-1 beta inhibited [3H]thymidine incorporation into TP cells in a dose-dependent manner and decreased TP cell number.	Thymidine	43-52	interleukin 1 beta	Homo sapiens	19-28
7745015-6	1995	In NP cells, treatment with IFN gamma and IL-1 beta also decreased [3H]thymidine incorporation and cell number.	Tritium	68-70	interleukin 1 beta	Homo sapiens	42-51
7745015-6	1995	In NP cells, treatment with IFN gamma and IL-1 beta also decreased [3H]thymidine incorporation and cell number.	Thymidine	71-80	interleukin 1 beta	Homo sapiens	42-51
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Phorbol Esters	19-33	interleukin 1 beta	Homo sapiens	209-218
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Phorbol 12,13-Dibutyrate	35-59	interleukin 1 beta	Homo sapiens	209-218
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Phorbol 12,13-Dibutyrate	61-65	interleukin 1 beta	Homo sapiens	209-218
7538561-0	1995	Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.	Excitatory Amino Acids	30-51	interleukin 1 beta	Homo sapiens	0-18
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Tetradecanoylphorbol Acetate	71-102	interleukin 1 beta	Homo sapiens	209-218
7538561-2	1995	In the present study, we investigated the possible neuroprotective actions of the cytokine human recombinant interleukin-1 beta (hrIL-1 beta) against excitatory amino acid (EAA)-induced neurodegeneration in cultured primary cortical neurons.	Excitatory Amino Acids	150-171	interleukin 1 beta	Homo sapiens	109-127
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Tetradecanoylphorbol Acetate	104-107	interleukin 1 beta	Homo sapiens	209-218
7538561-2	1995	In the present study, we investigated the possible neuroprotective actions of the cytokine human recombinant interleukin-1 beta (hrIL-1 beta) against excitatory amino acid (EAA)-induced neurodegeneration in cultured primary cortical neurons.	Excitatory Amino Acids	173-176	interleukin 1 beta	Homo sapiens	109-127
7649354-3	1995	The regulation of IL-1 beta production by the gonadal steroids was tested in the human osteoblastic HOBIT cell model.	Steroids	54-62	interleukin 1 beta	Homo sapiens	18-27
7649354-4	1995	Dose-dependent 4-8-fold increases (P &lt; 0.05) in IL-1 beta mRNA levels followed a 6-48 h treatment with 17 beta-estradiol or testosterone.	Estradiol	106-123	interleukin 1 beta	Homo sapiens	51-60
7649354-4	1995	Dose-dependent 4-8-fold increases (P &lt; 0.05) in IL-1 beta mRNA levels followed a 6-48 h treatment with 17 beta-estradiol or testosterone.	Testosterone	127-139	interleukin 1 beta	Homo sapiens	51-60
7649354-6	1995	Tumor necrosis factor-alpha (TNF) dependent increase IL-1 beta mRNA levels were additive to the effects of the steroids.	Steroids	111-119	interleukin 1 beta	Homo sapiens	53-62
7649354-7	1995	Testosterone and TNF increased IL-1 beta protein release (P &lt; 0.05) while 17 beta-estradiol had little effect on release.	Testosterone	0-12	interleukin 1 beta	Homo sapiens	31-40
7649354-8	1995	The bone-sparing effects of the gonadal steroids may be accomplished, in part, through their mediation of local IL-1 beta production.	Steroids	40-48	interleukin 1 beta	Homo sapiens	112-121
7706748-0	1995	Taxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion.	Paclitaxel	0-5	interleukin 1 beta	Homo sapiens	42-55
7737113-0	1995	Potassium-inhibited processing of IL-1 beta in human monocytes.	Potassium	0-9	interleukin 1 beta	Homo sapiens	34-43
7737113-4	1995	The central role of K+ depletion for inducing IL-1 beta maturation was demonstrated in cells permeabilized with alpha-toxin: processing of pro-IL-1 beta was totally blocked when cells were suspended in medium that contained high K+, but could be induced by replacing extracellular K+ with Na+, choline+ or sucrose.	Choline	294-302	interleukin 1 beta	Homo sapiens	139-152
7737113-4	1995	The central role of K+ depletion for inducing IL-1 beta maturation was demonstrated in cells permeabilized with alpha-toxin: processing of pro-IL-1 beta was totally blocked when cells were suspended in medium that contained high K+, but could be induced by replacing extracellular K+ with Na+, choline+ or sucrose.	Sucrose	306-313	interleukin 1 beta	Homo sapiens	139-152
7706741-3	1995	We have demonstrated previously that TNF-alpha and IL-1 beta stimulate formation of PLAP before phospholipase A2 (PLA2) enzyme activation and production of eicosanoids.	Eicosanoids	156-167	interleukin 1 beta	Homo sapiens	51-60
7706741-8	1995	PLAP stimulation of TNF and IL-1 could be enhanced with co-treatment of cells with free fatty acids, such as arachidonic or linoleic acid, but it was not blocked completely by PLA2 inhibitors.	Fatty Acids, Nonesterified	83-99	interleukin 1 beta	Homo sapiens	28-32
7706741-8	1995	PLAP stimulation of TNF and IL-1 could be enhanced with co-treatment of cells with free fatty acids, such as arachidonic or linoleic acid, but it was not blocked completely by PLA2 inhibitors.	arachidonic	109-120	interleukin 1 beta	Homo sapiens	28-32
7706748-0	1995	Taxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion.	Paclitaxel	0-5	interleukin 1 beta	Homo sapiens	46-55
7706741-8	1995	PLAP stimulation of TNF and IL-1 could be enhanced with co-treatment of cells with free fatty acids, such as arachidonic or linoleic acid, but it was not blocked completely by PLA2 inhibitors.	Linoleic Acid	124-137	interleukin 1 beta	Homo sapiens	28-32
7706748-0	1995	Taxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion.	Colchicine	10-20	interleukin 1 beta	Homo sapiens	42-55
7706748-0	1995	Taxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion.	Colchicine	10-20	interleukin 1 beta	Homo sapiens	46-55
7706748-4	1995	For example, it is known that taxol and colchicine, two drugs that affect microtubule structure and function, increase LPS-induced IL-1 beta release.	Paclitaxel	30-35	interleukin 1 beta	Homo sapiens	131-140
7706748-4	1995	For example, it is known that taxol and colchicine, two drugs that affect microtubule structure and function, increase LPS-induced IL-1 beta release.	Colchicine	40-50	interleukin 1 beta	Homo sapiens	131-140
7706748-9	1995	These findings indicate that taxol and colchicine increase LPS-induced IL-1 beta release by an increase in the production of the precursor molecule.	Paclitaxel	29-34	interleukin 1 beta	Homo sapiens	71-80
7706748-9	1995	These findings indicate that taxol and colchicine increase LPS-induced IL-1 beta release by an increase in the production of the precursor molecule.	Colchicine	39-49	interleukin 1 beta	Homo sapiens	71-80
7890061-4	1995	The mean IL-1 beta, IL-6, and TNF-alpha mRNA levels were higher in the late secretory menstrual phase compared with the proliferative early secretory phase of the menstrual cycle both in endometria exposed to the copper IUD and in the control samples.	Copper	213-219	interleukin 1 beta	Homo sapiens	9-18
7546248-0	1995	Prevention of human recombinant interleukin-1 beta (rhIL-1 beta) embryolethality with progesterone or indomethacin.	Progesterone	86-98	interleukin 1 beta	Homo sapiens	32-50
7546248-0	1995	Prevention of human recombinant interleukin-1 beta (rhIL-1 beta) embryolethality with progesterone or indomethacin.	Indomethacin	102-114	interleukin 1 beta	Homo sapiens	32-50
7890061-5	1995	The IL-1 beta and TNF-alpha mRNA levels were significantly higher in endometria exposed to the copper IUD compared with the control endometria in the late secretory menstrual phase, whereas no difference was found in the expression of these cytokine mRNAs during the proliferative early secretory phase.	Copper	95-101	interleukin 1 beta	Homo sapiens	4-13
7890061-7	1995	In the levonorgestrel IUD-exposed endometria, the mean levels of IL-1 beta, TNF-alpha, and CSF-1 mRNA were similar to those in normal endometrium in the late secretory menstrual phase.	Levonorgestrel	7-21	interleukin 1 beta	Homo sapiens	65-74
7670931-3	1995	A concomitant dose-dependent production of both IL-1 beta and IL-2 in response to PMMA stimulation was detected.	Polymethyl Methacrylate	82-86	interleukin 1 beta	Homo sapiens	48-57
7670931-4	1995	Reverse transcription-polymerase chain reactions (RT-PCR) indicated that both IL-1 beta and IL-2 mRNA was present after 48 hours in culture with PMMA.	Polymethyl Methacrylate	145-149	interleukin 1 beta	Homo sapiens	78-87
7615646-0	1995	Interleukin-1 beta induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts.	Dinoprostone	110-126	interleukin 1 beta	Homo sapiens	0-18
7615469-5	1995	We observed that the exposure of ASM cells to human recombinant IL-1 beta or IL-6, in all studied concentrations, significantly increased the number of cells as well as [3H]thymidine incorporation into ASM cells.	Tritium	170-172	interleukin 1 beta	Homo sapiens	64-73
7782537-5	1995	Incorporation of [3H]thymidine (TdR) was increased in 3 Den-Fb and 3 Nor-Fb lines in the presence of interleukin-1-beta (IL-1 beta) (10 U/mL) and tumor necrosis factor-alpha (TNF-alpha) (from 10 to 100 U/mL).	3h]thymidine	18-30	interleukin 1 beta	Homo sapiens	101-119
7782537-5	1995	Incorporation of [3H]thymidine (TdR) was increased in 3 Den-Fb and 3 Nor-Fb lines in the presence of interleukin-1-beta (IL-1 beta) (10 U/mL) and tumor necrosis factor-alpha (TNF-alpha) (from 10 to 100 U/mL).	3h]thymidine	18-30	interleukin 1 beta	Homo sapiens	121-130
7783414-9	1995	We conclude that LPS-induced IL-1 beta secretion, but not total production, is impaired in PBMC from ESRD patients on long-term Cuprophan hemodialysis.	cuprammonium cellulose	128-137	interleukin 1 beta	Homo sapiens	29-38
7783414-4	1995	In contrast, LPS-induced IL-1 beta secretion (secreted amounts in % of total production) was similar to controls in uremic patients, but significantly reduced in ESRD patients on Cuprophan (P &lt; 0.01).	cuprammonium cellulose	179-188	interleukin 1 beta	Homo sapiens	25-34
7783414-6	1995	Increased IL-1 beta secretion coincided with a suppression in PGE2 synthesis (P &lt; 0.02).	Dinoprostone	62-66	interleukin 1 beta	Homo sapiens	10-19
7783414-11	1995	Hemodialysis with AN 69 suppresses endogenous PGE2 synthesis in PBMC which is associated with increased LPS-induced IL-1 beta secretion in the presence of unchanged total IL-1 beta production.	Dinoprostone	46-50	interleukin 1 beta	Homo sapiens	116-125
7783414-7	1995	Similarly, blockade of endogenous PGE2 by indomethacin increased LPS-induced IL-1 beta secretion (P &lt; 0.01) but did not enhance total IL-1 beta production in PBMC from controls and patients on Cuprophan hemodialysis.	Dinoprostone	34-38	interleukin 1 beta	Homo sapiens	77-86
7783414-7	1995	Similarly, blockade of endogenous PGE2 by indomethacin increased LPS-induced IL-1 beta secretion (P &lt; 0.01) but did not enhance total IL-1 beta production in PBMC from controls and patients on Cuprophan hemodialysis.	Indomethacin	42-54	interleukin 1 beta	Homo sapiens	77-86
7783414-12	1995	We speculate that PGE2 could inactivate the IL-1 beta converting enzyme which is essential for processing and secretion of mature IL-1 beta.	Dinoprostone	18-22	interleukin 1 beta	Homo sapiens	44-53
7783414-12	1995	We speculate that PGE2 could inactivate the IL-1 beta converting enzyme which is essential for processing and secretion of mature IL-1 beta.	Dinoprostone	18-22	interleukin 1 beta	Homo sapiens	130-139
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	29-34	interleukin 1 beta	Homo sapiens	106-124
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	29-34	interleukin 1 beta	Homo sapiens	126-136
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	64-69	interleukin 1 beta	Homo sapiens	126-136
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	64-69	interleukin 1 beta	Homo sapiens	106-124
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	64-69	interleukin 1 beta	Homo sapiens	106-124
7892604-1	1995	The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1 beta (hIL-1 beta) was investigated with water-selective two-dimensional heteronuclear magnetic resonance spectroscopy.	Water	64-69	interleukin 1 beta	Homo sapiens	126-136
7900866-2	1995	In IL-1 beta-treated endothelium-denuded rings, contractile responses to phenylephrine were reduced in SV rings only.	Phenylephrine	73-86	interleukin 1 beta	Homo sapiens	3-12
8614237-0	1995	A possible role for nitric oxide but not for prostaglandin E2 in basal and interleukin-1-beta-induced PRL release in vitro.	Nitric Oxide	20-32	interleukin 1 beta	Homo sapiens	75-93
8614237-3	1995	L-NG-nitro-arginine, an inhibitor of nitric oxide synthetase, and hemoglobin, a NO scavenger, impaired basal and interleukin-1-beta-induced PRL release, while molsidomine, a NO donor, was able to release PRL and to amplify interleukin-1-beta-induced PRL release, confirming a modulatory role for nitric oxide in pituitary hormone secretion.	Nitroarginine	0-19	interleukin 1 beta	Homo sapiens	113-131
7873203-0	1995	Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts.	Dinoprostone	78-94	interleukin 1 beta	Homo sapiens	49-67
7873203-7	1995	These results indicate that IL-1 beta induces cyclooxygenase-2 rather than cyclooxygenase-1 in IMR-90 cells and this induction is responsible for the augmentation of PGE2 production stimulated with IL-1 beta.	Dinoprostone	166-170	interleukin 1 beta	Homo sapiens	28-37
7873203-1	1995	Because interleukin-1 beta (IL-1 beta) increases the synthesis of prostaglandin E2 (PGE2) in human lung fibroblasts, the effect of IL-1 beta on the expression of two isozymes of cyclooxygenase (cyclooxygenase-1 and -2) in human embryonic lung fibroblasts (IMR-90) was investigated in terms of three parameters (PGE2 release, cyclooxygenase activity, and mRNA).	Dinoprostone	66-82	interleukin 1 beta	Homo sapiens	8-26
7873203-7	1995	These results indicate that IL-1 beta induces cyclooxygenase-2 rather than cyclooxygenase-1 in IMR-90 cells and this induction is responsible for the augmentation of PGE2 production stimulated with IL-1 beta.	Dinoprostone	166-170	interleukin 1 beta	Homo sapiens	198-207
7873203-1	1995	Because interleukin-1 beta (IL-1 beta) increases the synthesis of prostaglandin E2 (PGE2) in human lung fibroblasts, the effect of IL-1 beta on the expression of two isozymes of cyclooxygenase (cyclooxygenase-1 and -2) in human embryonic lung fibroblasts (IMR-90) was investigated in terms of three parameters (PGE2 release, cyclooxygenase activity, and mRNA).	Dinoprostone	66-82	interleukin 1 beta	Homo sapiens	28-37
7873203-8	1995	However, the inhibition of the IL-1 beta-induced PGE2 synthesis by IL-4 was not mediated by the down-regulation of cyclooxygenase-2.	Dinoprostone	49-53	interleukin 1 beta	Homo sapiens	31-40
7873203-1	1995	Because interleukin-1 beta (IL-1 beta) increases the synthesis of prostaglandin E2 (PGE2) in human lung fibroblasts, the effect of IL-1 beta on the expression of two isozymes of cyclooxygenase (cyclooxygenase-1 and -2) in human embryonic lung fibroblasts (IMR-90) was investigated in terms of three parameters (PGE2 release, cyclooxygenase activity, and mRNA).	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	8-26
7873203-1	1995	Because interleukin-1 beta (IL-1 beta) increases the synthesis of prostaglandin E2 (PGE2) in human lung fibroblasts, the effect of IL-1 beta on the expression of two isozymes of cyclooxygenase (cyclooxygenase-1 and -2) in human embryonic lung fibroblasts (IMR-90) was investigated in terms of three parameters (PGE2 release, cyclooxygenase activity, and mRNA).	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	28-37
7873203-2	1995	When the cells were incubated with IL-1 beta, both the PGE2 release to the culture medium and the cyclooxygenase activity in the cell lysate increased in a dose- and time-dependent manner, and both were inhibited by NS-398 (a cyclooxygenase-2-specific inhibitor).	Dinoprostone	55-59	interleukin 1 beta	Homo sapiens	35-44
7873203-2	1995	When the cells were incubated with IL-1 beta, both the PGE2 release to the culture medium and the cyclooxygenase activity in the cell lysate increased in a dose- and time-dependent manner, and both were inhibited by NS-398 (a cyclooxygenase-2-specific inhibitor).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	216-222	interleukin 1 beta	Homo sapiens	35-44
7873203-3	1995	Dexamethasone and interleukin-4 (IL-4) inhibited the IL-1 beta-induced PGE2 synthesis; the former inhibited the IL-1 beta-induced cyclooxygenase activity whereas the latter failed.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	53-62
7873203-3	1995	Dexamethasone and interleukin-4 (IL-4) inhibited the IL-1 beta-induced PGE2 synthesis; the former inhibited the IL-1 beta-induced cyclooxygenase activity whereas the latter failed.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	112-121
7873203-3	1995	Dexamethasone and interleukin-4 (IL-4) inhibited the IL-1 beta-induced PGE2 synthesis; the former inhibited the IL-1 beta-induced cyclooxygenase activity whereas the latter failed.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	53-62
7873203-3	1995	Dexamethasone and interleukin-4 (IL-4) inhibited the IL-1 beta-induced PGE2 synthesis; the former inhibited the IL-1 beta-induced cyclooxygenase activity whereas the latter failed.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	112-121
7873203-6	1995	Dexamethasone inhibited the IL-1 beta-induced mRNA expression of cyclooxygenase-2 whereas IL-4 failed.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	28-37
7728399-2	1995	At non-toxic concentrations MTX-LIPO (10 micrograms MTX per 250 micrograms lipid) was a potent inhibitor of both IL-1 beta and TNF release resulting in 70.07 +/- 2.3% and 59.19 +/- 2.36% (mean +/- S.E.M.)	mtx-lipo	28-36	interleukin 1 beta	Homo sapiens	113-122
7728399-2	1995	At non-toxic concentrations MTX-LIPO (10 micrograms MTX per 250 micrograms lipid) was a potent inhibitor of both IL-1 beta and TNF release resulting in 70.07 +/- 2.3% and 59.19 +/- 2.36% (mean +/- S.E.M.)	Methotrexate	28-31	interleukin 1 beta	Homo sapiens	113-122
7789482-9	1995	Co-stimulation of IL-1 beta with H2O2 led to augmentation and prolongation of the effect on NF-kappa B activation compared to stimulation with IL-1 beta alone.	Hydrogen Peroxide	33-37	interleukin 1 beta	Homo sapiens	143-152
7538612-5	1995	IL-6 had no direct stimulatory effect on its own, but synergized with IL-1 to induce an increased production of C3 in the culture supernatant and its relative amount was confirmed by SDS-PAGE and immunoblot.	Sodium Dodecyl Sulfate	183-186	interleukin 1 beta	Homo sapiens	70-74
7789482-9	1995	Co-stimulation of IL-1 beta with H2O2 led to augmentation and prolongation of the effect on NF-kappa B activation compared to stimulation with IL-1 beta alone.	Hydrogen Peroxide	33-37	interleukin 1 beta	Homo sapiens	18-27
7875467-8	1995	However, induction of IL-8 by IL-1 beta or TNF-alpha was reduced by the PTK inhibitors herbimycin (by 79% or 89%, respectively) and genistein (by &gt; 95%).	herbimycin	87-97	interleukin 1 beta	Homo sapiens	30-39
7875467-8	1995	However, induction of IL-8 by IL-1 beta or TNF-alpha was reduced by the PTK inhibitors herbimycin (by 79% or 89%, respectively) and genistein (by &gt; 95%).	Genistein	132-141	interleukin 1 beta	Homo sapiens	30-39
7875768-4	1995	Treatment of cardiocytes with 3.4 nmol/L IL-1 beta for 24 hours stimulated NO (nitrite) production by threefold, which resulted from an increase in the inducible isoform of NO synthase mRNA.	Nitrites	79-86	interleukin 1 beta	Homo sapiens	41-50
7875768-5	1995	Dexamethasone inhibited IL-1 beta induction of nitrite production, whereas the protein kinase C inhibitor staurosporine had no effect.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	24-33
7875768-5	1995	Dexamethasone inhibited IL-1 beta induction of nitrite production, whereas the protein kinase C inhibitor staurosporine had no effect.	Nitrites	47-54	interleukin 1 beta	Homo sapiens	24-33
7875768-6	1995	IL-1 beta had no effect on either basal or phenylephrine-stimulated protein content but inhibited phenylephrine-stimulated BNP secretion.	Phenylephrine	98-111	interleukin 1 beta	Homo sapiens	0-9
7875768-11	1995	However, IL-1 beta inhibits phenylephrine-stimulated BNP secretion but not total protein content, suggesting that regulation of BNP secretion can be dissociated from total protein synthesis during myocyte growth.	Phenylephrine	28-41	interleukin 1 beta	Homo sapiens	9-18
7790046-5	1995	The most accredited mechanism of action of IL-1 in inflammatory diseases is the stimulation of PGE2 release, which is highly dependent on the concentration of IL-1.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	43-47
7790046-5	1995	The most accredited mechanism of action of IL-1 in inflammatory diseases is the stimulation of PGE2 release, which is highly dependent on the concentration of IL-1.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	159-163
7790046-9	1995	In fact, the cell cultures treated with hrIL-6 plus hrIL-1 caused a higher release approximately 1.5-4-fold of SAA protein than the cells treated with IL-6 plus PGE2 5 microM or IL-1 + PGE2 5 microM, respectively.	Dinoprostone	185-189	interleukin 1 beta	Homo sapiens	54-58
7790046-10	1995	The synergistic effect of hrIL-6 plus hrIL-1 beta was inhibited by hrIL-1 receptor antagonist (hrIL-1ra) 50 micrograms/ml, a protein which specifically binds to the IL-1 receptor and is structurally similar to IL-1 beta but with no IL-1-like activity; while indomethacin (5 microM) was ineffective.	Indomethacin	258-270	interleukin 1 beta	Homo sapiens	40-44
7790046-10	1995	The synergistic effect of hrIL-6 plus hrIL-1 beta was inhibited by hrIL-1 receptor antagonist (hrIL-1ra) 50 micrograms/ml, a protein which specifically binds to the IL-1 receptor and is structurally similar to IL-1 beta but with no IL-1-like activity; while indomethacin (5 microM) was ineffective.	Indomethacin	258-270	interleukin 1 beta	Homo sapiens	40-49
7790046-10	1995	The synergistic effect of hrIL-6 plus hrIL-1 beta was inhibited by hrIL-1 receptor antagonist (hrIL-1ra) 50 micrograms/ml, a protein which specifically binds to the IL-1 receptor and is structurally similar to IL-1 beta but with no IL-1-like activity; while indomethacin (5 microM) was ineffective.	Indomethacin	258-270	interleukin 1 beta	Homo sapiens	69-73
7891349-0	1995	Differential regulation of human monocyte-derived TNF alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors.	Cyclic AMP	85-89	interleukin 1 beta	Homo sapiens	64-73
7891349-0	1995	Differential regulation of human monocyte-derived TNF alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors.	Cyclic AMP	109-113	interleukin 1 beta	Homo sapiens	64-73
7891349-1	1995	Elevation of cAMP downregulates certain functions of inflammatory cells, including the release of TNF alpha and IL-1 beta by macrophages.	Cyclic AMP	13-17	interleukin 1 beta	Homo sapiens	112-121
7891349-5	1995	Our results demonstrate that selective inhibitors of type IV cAMP-PDE, such as rolipram and Ro20-1724, are clearly the most effective compounds at enhancing cAMP levels and inhibiting the release of TNF alpha and IL-1 beta in these cells.	Cyclic AMP	61-65	interleukin 1 beta	Homo sapiens	213-222
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Rolipram	14-22	interleukin 1 beta	Homo sapiens	59-68
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Rolipram	14-22	interleukin 1 beta	Homo sapiens	173-182
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Rolipram	24-32	interleukin 1 beta	Homo sapiens	59-68
7652185-6	1995	PGE2 synthesis was increased by 24 h culture with IL-1 beta in all the cell preparations, indicating that the cells were biologically active, and that the lack of effect of changes in cyclic AMP synthesis on PGE2 levels could not be attributed to a defect in the prostaglandin synthetic pathway.	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	50-59
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Rolipram	24-32	interleukin 1 beta	Homo sapiens	173-182
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Bucladesine	34-40	interleukin 1 beta	Homo sapiens	59-68
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Bucladesine	34-40	interleukin 1 beta	Homo sapiens	173-182
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Alprostadil	44-48	interleukin 1 beta	Homo sapiens	59-68
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Alprostadil	44-48	interleukin 1 beta	Homo sapiens	173-182
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Cyclic AMP	36-40	interleukin 1 beta	Homo sapiens	59-68
7891349-9	1995	Surprisingly, rolipram, rolipram, dbcAMP or PGE1 increased IL-1 beta was reduced, which indicates that cAMP can have both positive and negative effects on the regulation of IL-1 beta.	Cyclic AMP	36-40	interleukin 1 beta	Homo sapiens	173-182
7789612-9	1995	In the presence cycloheximide, IL-1 beta markedly stimulated preproET-1 mRNA expression, whereas EGF was less effective.	Cycloheximide	16-29	interleukin 1 beta	Homo sapiens	31-40
7792282-0	1995	Cytokines in the viviparous reproduction of squamate reptiles: interleukin-1 alpha (IL-1 alpha) and IL-1 beta in placental structures of a skink.	squamate	44-52	interleukin 1 beta	Homo sapiens	100-109
7780821-2	1995	Using the in situ hybridization of biotin-labeled probe and streptavidin -alkaline phosphatase conjugate detection system, we quantitatively analysed by true colour medical image analysis system the expression of IL-1 beta, IL-1ra mRNA of peripheral blood mononuclear cells (PBMC) from 4 cases of idiopathic nephrotic syndrome.	Biotin	35-41	interleukin 1 beta	Homo sapiens	213-222
7551978-1	1995	This study evaluates the ability of the immunosuppressive drugs dexamethasone, cyclosporine, FK506 and rapamycin, alone and in combination to suppress interleukin-1 beta (IL-1 beta) secretion in vitro by THP-1 cells when stimulated by lipopolysaccharide.	Dexamethasone	64-77	interleukin 1 beta	Homo sapiens	151-169
7551978-1	1995	This study evaluates the ability of the immunosuppressive drugs dexamethasone, cyclosporine, FK506 and rapamycin, alone and in combination to suppress interleukin-1 beta (IL-1 beta) secretion in vitro by THP-1 cells when stimulated by lipopolysaccharide.	Dexamethasone	64-77	interleukin 1 beta	Homo sapiens	171-180
7551978-1	1995	This study evaluates the ability of the immunosuppressive drugs dexamethasone, cyclosporine, FK506 and rapamycin, alone and in combination to suppress interleukin-1 beta (IL-1 beta) secretion in vitro by THP-1 cells when stimulated by lipopolysaccharide.	Cyclosporine	79-91	interleukin 1 beta	Homo sapiens	151-169
7551978-1	1995	This study evaluates the ability of the immunosuppressive drugs dexamethasone, cyclosporine, FK506 and rapamycin, alone and in combination to suppress interleukin-1 beta (IL-1 beta) secretion in vitro by THP-1 cells when stimulated by lipopolysaccharide.	Cyclosporine	79-91	interleukin 1 beta	Homo sapiens	171-180
7551978-1	1995	This study evaluates the ability of the immunosuppressive drugs dexamethasone, cyclosporine, FK506 and rapamycin, alone and in combination to suppress interleukin-1 beta (IL-1 beta) secretion in vitro by THP-1 cells when stimulated by lipopolysaccharide.	Tacrolimus	93-98	interleukin 1 beta	Homo sapiens	151-169
7551978-1	1995	This study evaluates the ability of the immunosuppressive drugs dexamethasone, cyclosporine, FK506 and rapamycin, alone and in combination to suppress interleukin-1 beta (IL-1 beta) secretion in vitro by THP-1 cells when stimulated by lipopolysaccharide.	Tacrolimus	93-98	interleukin 1 beta	Homo sapiens	171-180
7551978-1	1995	This study evaluates the ability of the immunosuppressive drugs dexamethasone, cyclosporine, FK506 and rapamycin, alone and in combination to suppress interleukin-1 beta (IL-1 beta) secretion in vitro by THP-1 cells when stimulated by lipopolysaccharide.	Sirolimus	103-112	interleukin 1 beta	Homo sapiens	151-169
7551978-1	1995	This study evaluates the ability of the immunosuppressive drugs dexamethasone, cyclosporine, FK506 and rapamycin, alone and in combination to suppress interleukin-1 beta (IL-1 beta) secretion in vitro by THP-1 cells when stimulated by lipopolysaccharide.	Sirolimus	103-112	interleukin 1 beta	Homo sapiens	171-180
7551978-3	1995	However, only dexamethasone completely suppresses IL-1 beta secretion in a dose-dependent fashion.	Dexamethasone	14-27	interleukin 1 beta	Homo sapiens	50-59
7551978-4	1995	Cyclosporine, FK506 and rapamycin only partially suppress secretion of IL-1 beta at concentrations within their therapeutic ranges and increasing concentrations of the drugs do not result in further suppression of secretion.	Cyclosporine	0-12	interleukin 1 beta	Homo sapiens	71-80
7551978-4	1995	Cyclosporine, FK506 and rapamycin only partially suppress secretion of IL-1 beta at concentrations within their therapeutic ranges and increasing concentrations of the drugs do not result in further suppression of secretion.	Tacrolimus	14-19	interleukin 1 beta	Homo sapiens	71-80
7551978-4	1995	Cyclosporine, FK506 and rapamycin only partially suppress secretion of IL-1 beta at concentrations within their therapeutic ranges and increasing concentrations of the drugs do not result in further suppression of secretion.	Sirolimus	24-33	interleukin 1 beta	Homo sapiens	71-80
7551978-6	1995	Dexamethasone, however, when added in increasing concentrations in combination with any of the other drugs, results in further suppression of IL-1 secretion in a dose-dependent fashion.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	142-146
7551978-7	1995	These data suggest that cyclosporine, FK506 and rapamycin all share a common effect on the production of IL-1 beta, different from that of dexamethasone.	Cyclosporine	24-36	interleukin 1 beta	Homo sapiens	105-114
7551978-7	1995	These data suggest that cyclosporine, FK506 and rapamycin all share a common effect on the production of IL-1 beta, different from that of dexamethasone.	Tacrolimus	38-43	interleukin 1 beta	Homo sapiens	105-114
7551978-7	1995	These data suggest that cyclosporine, FK506 and rapamycin all share a common effect on the production of IL-1 beta, different from that of dexamethasone.	Sirolimus	48-57	interleukin 1 beta	Homo sapiens	105-114
7726748-6	1995	Moreover, the effect of dexamethasone on ICAM-1 expression stimulated by IL-1 beta, TNF-alpha and IFN-gamma was observed.	Dexamethasone	24-37	interleukin 1 beta	Homo sapiens	73-82
7878046-8	1995	The type II cell surface IL-1 receptor failed to bind the biologically inactive IL-1 beta precursor molecule, but binding to the IL-1 beta precursor was observed on cellular release of the receptor; this was confirmed with 35S-labeled IL-1 beta.	Sulfur-35	223-226	interleukin 1 beta	Homo sapiens	129-138
7878046-8	1995	The type II cell surface IL-1 receptor failed to bind the biologically inactive IL-1 beta precursor molecule, but binding to the IL-1 beta precursor was observed on cellular release of the receptor; this was confirmed with 35S-labeled IL-1 beta.	Sulfur-35	223-226	interleukin 1 beta	Homo sapiens	129-138
7878046-10	1995	These observations suggest that the type II sIL-1R inhibits IL-1 beta at two steps, by preventing processing of propeptide and by blocking the interaction of mature IL-1 beta with type I IL-1 receptor.	propeptide	112-122	interleukin 1 beta	Homo sapiens	60-69
7726748-8	1995	Inhibitory effects were exerted by dexamethasone on ICAM-1 expression in cells stimulated by IL-1 beta and IFN-gamma in a dose-dependent manner, but not in cells stimulated by TNF-alpha.	Dexamethasone	35-48	interleukin 1 beta	Homo sapiens	93-102
7704454-5	1995	IL-1 beta significantly enhanced C4S production and significantly suppressed C6S production.	c4s	33-36	interleukin 1 beta	Homo sapiens	0-9
7704454-5	1995	IL-1 beta significantly enhanced C4S production and significantly suppressed C6S production.	c6s	77-80	interleukin 1 beta	Homo sapiens	0-9
7729711-4	1995	RESULTS: Based upon the effectiveness of indomethacin, the anterior uveitis induced by IL-1 beta/TNF alpha could be divided into two phases; a primary phase dependent upon generation of cyclooxygenase metabolites (the first 24 h) and a secondary phase largely independent of cyclooxygenase metabolite production (24-48 h).	Indomethacin	41-53	interleukin 1 beta	Homo sapiens	87-96
7781745-2	1995	Since these cytokines have been shown to alter the adenylyl cyclase system in nonocular tissues, we tested the hypothesis that IL-1 beta and TNF alpha affect the anterior uvea by altering production of the intracellular second messenger adenosine 3",5"-cyclic monophosphate (cAMP) in ciliary epithelial bilayers.	Cyclic AMP	237-273	interleukin 1 beta	Homo sapiens	127-136
7781745-2	1995	Since these cytokines have been shown to alter the adenylyl cyclase system in nonocular tissues, we tested the hypothesis that IL-1 beta and TNF alpha affect the anterior uvea by altering production of the intracellular second messenger adenosine 3",5"-cyclic monophosphate (cAMP) in ciliary epithelial bilayers.	Cyclic AMP	275-279	interleukin 1 beta	Homo sapiens	127-136
7781745-4	1995	Although cAMP production was enhanced in bilayers from IL-1 beta-, TNF alpha- or endotoxin-inflamed eyes, ex vivo, exposure of normal bilayers to IL-1 beta (15 U ml-1), TNF alpha (20 U ml-1), or a low concentration of endotoxin (0.01 microgram ml-1) for 4 hr, in vitro, had no effect on cAMP production.	Cyclic AMP	9-13	interleukin 1 beta	Homo sapiens	55-64
7822806-0	1995	Inhibition of lipopolysaccharide-induced IL-1 beta transcription by cyclic adenosine monophosphate in human astrocytic cells.	Cyclic AMP	68-98	interleukin 1 beta	Homo sapiens	41-50
7531717-0	1995	Decidual histamine release and amplification of prostaglandin F2 alpha production by histamine in interleukin-1 beta-primed decidual cells: potential interactive role for inflammatory mediators in uterine function at term.	Dinoprost	48-64	interleukin 1 beta	Homo sapiens	98-116
7531717-0	1995	Decidual histamine release and amplification of prostaglandin F2 alpha production by histamine in interleukin-1 beta-primed decidual cells: potential interactive role for inflammatory mediators in uterine function at term.	Histamine	85-94	interleukin 1 beta	Homo sapiens	98-116
7531717-6	1995	Pretreatment of cells with IL-1 beta enhanced maximal PGF2 alpha production in response to histamine by approximately 4-fold.	Dinoprost	54-64	interleukin 1 beta	Homo sapiens	27-36
7531717-6	1995	Pretreatment of cells with IL-1 beta enhanced maximal PGF2 alpha production in response to histamine by approximately 4-fold.	Histamine	91-100	interleukin 1 beta	Homo sapiens	27-36
7738074-3	1995	On day 1, the neutral surface FEP polymer with incorporated amide (NH2) groups showed the greatest inhibition of adhesion, 89% (P &lt; .01), and cytokine production (IL-1 beta with 58%, IL-6 with 70%, and TNF-alpha with 39%) compared to control TCPS.	Amides	60-65	interleukin 1 beta	Homo sapiens	166-175
7582555-8	1995	The effects of a steroidal (dexamethasone) and a non-steroidal (indomethacin) anti-inflammatory drug on the levels of NGF and IL-1 beta in inflamed tissue were investigated and compared with alterations in behavioural hyperalgesia and neuropeptide expression in sensory neurones.	Dexamethasone	28-41	interleukin 1 beta	Homo sapiens	126-135
7582555-8	1995	The effects of a steroidal (dexamethasone) and a non-steroidal (indomethacin) anti-inflammatory drug on the levels of NGF and IL-1 beta in inflamed tissue were investigated and compared with alterations in behavioural hyperalgesia and neuropeptide expression in sensory neurones.	Indomethacin	64-76	interleukin 1 beta	Homo sapiens	126-135
7582555-16	1995	Dexamethasone at the lower and higher dose regimes diminished the upregulation of IL-1 beta whereas indomethacin had an effect only at the higher dose.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	82-91
7822806-3	1995	cAMP has been implicated in LPS signaling as a positive regulator of IL-1 beta mRNA accumulation in monocytes.	Cyclic AMP	0-4	interleukin 1 beta	Homo sapiens	69-78
7822806-4	1995	In this study, we demonstrate that in human astrocytes (both fetal and the astrocytoma cell line, U-373 MG), agents that elevate intracellular cAMP decrease LPS-induced IL-1 beta mRNA accumulation.	Cyclic AMP	143-147	interleukin 1 beta	Homo sapiens	169-178
7822806-5	1995	Elevated intracellular cAMP does not affect IL-1 beta mRNA stability, but inhibits LPS-induced transcription initiation of IL-1 beta in U-373 MG cells.	Cyclic AMP	23-27	interleukin 1 beta	Homo sapiens	123-132
7822806-6	1995	Elevated intracellular cAMP may be a negative feedback regulatory mechanism to inhibit IL-1 beta production employed by astrocytes that (unlike monocytic cells) lack a glycosyl-phosphatidylinositol (GPI)-anchored form of the LPS receptor, CD14.	Cyclic AMP	23-27	interleukin 1 beta	Homo sapiens	87-96
7822806-6	1995	Elevated intracellular cAMP may be a negative feedback regulatory mechanism to inhibit IL-1 beta production employed by astrocytes that (unlike monocytic cells) lack a glycosyl-phosphatidylinositol (GPI)-anchored form of the LPS receptor, CD14.	Glycosylphosphatidylinositols	168-197	interleukin 1 beta	Homo sapiens	87-96
7755487-5	1995	It was demonstrated that incubation with 1, 10 and 100 nM TCDD for 24 h increased mRNA levels of TGF-alpha, TNF-alpha and IL-1 beta.	Polychlorinated Dibenzodioxins	58-62	interleukin 1 beta	Homo sapiens	122-131
7853198-6	1995	Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	146-149	interleukin 1 beta	Homo sapiens	56-65
7853198-6	1995	Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin.	aplysiatoxin	151-163	interleukin 1 beta	Homo sapiens	56-65
7853198-6	1995	Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin.	teleocidins	167-177	interleukin 1 beta	Homo sapiens	56-65
7853198-8	1995	The present work indicates that the production of cell-associated IL-1 alpha stimulated by TNF-alpha, IL-1 beta or lipopolysaccharide is inhibited by treatment with TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 beta	Homo sapiens	102-111
7853198-8	1995	The present work indicates that the production of cell-associated IL-1 alpha stimulated by TNF-alpha, IL-1 beta or lipopolysaccharide is inhibited by treatment with TPA, aplysiatoxin or teleocidin.	teleocidins	186-196	interleukin 1 beta	Homo sapiens	102-111
7536905-3	1995	Treatment of neuron cultures for 24 h with the combined stimulation of IFN-gamma plus IL-1 beta, TNF-alpha and LPS induced NOS activity by 87-fold which was calcium-independent.	Calcium	157-164	interleukin 1 beta	Homo sapiens	86-95
7598438-4	1995	The CSFs with detectable TNF alpha or IL1 beta had higher levels of IL6 (p &lt; 0.02), protein (NS) and lower glucose levels (p &lt; 0.02), compared with those in which TNF alpha and IL1 beta were absent.	Glucose	110-117	interleukin 1 beta	Homo sapiens	38-46
7730146-7	1995	In fresh leukemia cells, 3H-thymidine uptake was generally higher in IL-1-producing cases than in IL-1ra-producing cases, and was increased by the addition of IL-1 beta in all cases tested.	3h-thymidine	25-37	interleukin 1 beta	Homo sapiens	159-168
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Prostaglandins	30-43	interleukin 1 beta	Homo sapiens	0-18
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Dinoprostone	120-136	interleukin 1 beta	Homo sapiens	0-18
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Dinoprostone	138-142	interleukin 1 beta	Homo sapiens	0-18
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Tetradecanoylphorbol Acetate	196-221	interleukin 1 beta	Homo sapiens	0-18
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Tetradecanoylphorbol Acetate	223-226	interleukin 1 beta	Homo sapiens	0-18
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Staurosporine	262-275	interleukin 1 beta	Homo sapiens	0-18
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Dinoprostone	357-361	interleukin 1 beta	Homo sapiens	0-18
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Dinoprostone	42-46	interleukin 1 beta	Homo sapiens	0-18
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Dinoprostone	42-46	interleukin 1 beta	Homo sapiens	20-29
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Dinoprostone	42-46	interleukin 1 beta	Homo sapiens	132-141
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Tetradecanoylphorbol Acetate	94-97	interleukin 1 beta	Homo sapiens	0-18
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Tetradecanoylphorbol Acetate	94-97	interleukin 1 beta	Homo sapiens	20-29
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Tetradecanoylphorbol Acetate	94-97	interleukin 1 beta	Homo sapiens	132-141
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Staurosporine	101-114	interleukin 1 beta	Homo sapiens	0-18
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Staurosporine	101-114	interleukin 1 beta	Homo sapiens	20-29
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Staurosporine	101-114	interleukin 1 beta	Homo sapiens	132-141
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Dinoprostone	181-185	interleukin 1 beta	Homo sapiens	0-18
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Dinoprostone	181-185	interleukin 1 beta	Homo sapiens	20-29
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Dinoprostone	181-185	interleukin 1 beta	Homo sapiens	132-141
7856740-1	1995	Chondrocytes stimulated with IL-1 produce high levels of nitric oxide (NO), which inhibits proliferation induced by transforming growth factor-beta or serum.	Nitric Oxide	57-69	interleukin 1 beta	Homo sapiens	29-33
7856740-8	1995	IL-1-stimulated chondrocytes are known to produce oxygen radicals that react with NO to form products that can induce cell death in other systems.	Reactive Oxygen Species	50-65	interleukin 1 beta	Homo sapiens	0-4
7856740-10	1995	Under these conditions IL-1 was able to induce apoptosis, which was inhibited in a dose-dependent manner by the NO synthase inhibitor N-monomethyl L-arginine.	omega-N-Methylarginine	134-157	interleukin 1 beta	Homo sapiens	23-27
7774103-4	1995	By contrast, PMA-induced production of IL-1 beta was impaired in RA patients and was preceded by the disregulated expression of c-Fos and c-Jun proteins when compared with healthy donors.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 beta	Homo sapiens	39-48
7670884-0	1995	Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated.	Corticosterone	27-41	interleukin 1 beta	Homo sapiens	0-18
7623327-2	1995	Gonadotrophin-stimulated progesterone production is inhibited by interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), or gamma-interferon (IFN-gamma), the last two cytokine being more effective than IL-1.	Progesterone	25-37	interleukin 1 beta	Homo sapiens	65-83
7813105-7	1995	IL-1 mRNA occurred in the zona reticularis in 17 alpha-hydroxylase positive steroid cells surrounding the adrenomedullary cells.	Steroids	76-83	interleukin 1 beta	Homo sapiens	0-4
7654630-4	1995	Monocytes/macrophages incubated on PDMS, silicone rubber and low density polyethylene, LDPE, with or without protein adsorption produced variable levels of IL-1 beta, IL-6 and TNF-alpha dependent on the polymer and adsorbed protein.	Silicones	41-49	interleukin 1 beta	Homo sapiens	156-165
7654630-4	1995	Monocytes/macrophages incubated on PDMS, silicone rubber and low density polyethylene, LDPE, with or without protein adsorption produced variable levels of IL-1 beta, IL-6 and TNF-alpha dependent on the polymer and adsorbed protein.	Polyethylene	73-85	interleukin 1 beta	Homo sapiens	156-165
7623327-2	1995	Gonadotrophin-stimulated progesterone production is inhibited by interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), or gamma-interferon (IFN-gamma), the last two cytokine being more effective than IL-1.	Progesterone	25-37	interleukin 1 beta	Homo sapiens	85-94
7623327-2	1995	Gonadotrophin-stimulated progesterone production is inhibited by interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), or gamma-interferon (IFN-gamma), the last two cytokine being more effective than IL-1.	Progesterone	25-37	interleukin 1 beta	Homo sapiens	85-89
7612737-7	1995	Due to less contaminating glucose degradation products in PD-Bio, basal cytotoxicity was significantly decreased for both 1.5% and 4% glucose-containing fluids, and the stimulated release of interleukin-1 beta was normalized compared to sterile filtered controls with the same pH.	Glucose	26-33	interleukin 1 beta	Homo sapiens	191-209
7731159-2	1995	Exposure of HPMC to PDF pH 5.2 resulted in a time-dependent increase in cell cytotoxicity [as assessed by lactate dehydrogenase (LDH) release] and concomitant inhibition of constitutive and IL-1 beta stimulated IL-6 and 6-keto-PGF1 alpha synthesis.	hydroxypropylmethylcellulose-lactose matrix	12-16	interleukin 1 beta	Homo sapiens	190-199
7731159-9	1995	Under these conditions short term exposure to PDF pH 5.2 followed by "in vitro dialysis" resulted in significant inhibition of cytokine stimulated IL-6 (69.6 +/- 18.2 vs. 96.7 +/- 27.9 pg/microgram, N = 13; P &lt; 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P &lt; 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P &lt; 0.003) release when compared to cells incubated in control medium.	pdf	46-49	interleukin 1 beta	Homo sapiens	224-233
7731159-9	1995	Under these conditions short term exposure to PDF pH 5.2 followed by "in vitro dialysis" resulted in significant inhibition of cytokine stimulated IL-6 (69.6 +/- 18.2 vs. 96.7 +/- 27.9 pg/microgram, N = 13; P &lt; 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P &lt; 0.020 for IL-1 beta) and 6-keto-PGF1 alpha (197.5 +/- 89.2 vs. 289.6 +/- 114.5 pg/microgram, N = 13; P &lt; 0.003) release when compared to cells incubated in control medium.	pdf	46-49	interleukin 1 beta	Homo sapiens	332-341
7623615-3	1995	Recombinant human (rh) IL-1 beta, at a dose of 10(-11) mol/l only, produced a very small increase in basal TSH secretion after 4h, but not 20h, exposure.	Thyrotropin	107-110	interleukin 1 beta	Homo sapiens	23-32
7708925-6	1995	It is hypothesized that increased monocytic production of interleukins (Il-1 beta and Il-6) in severe depression may constitute key phenomena underlying the various aspects of the immune and "acute" phase response, while contributing to hypothalamic-pituitary-adrenal-axis hyperactivity, disorders in serotonin metabolism, and to the vegetative symptoms (i.e. the sickness behavior) of severe depression.	Serotonin	301-310	interleukin 1 beta	Homo sapiens	72-81
7792388-0	1995	Interleukin-1 beta-stimulated PGE2 production from early first trimester human decidual cells is inhibited by dexamethasone and progesterone.	Dexamethasone	110-123	interleukin 1 beta	Homo sapiens	0-18
7792388-0	1995	Interleukin-1 beta-stimulated PGE2 production from early first trimester human decidual cells is inhibited by dexamethasone and progesterone.	Progesterone	128-140	interleukin 1 beta	Homo sapiens	0-18
7792388-4	1995	Interleukin-1 beta stimulated the production of prostaglandins E2 and F2 alpha dose-dependently, and this was associated with increased numbers of COX-2 positive cells.	Dinoprostone	48-65	interleukin 1 beta	Homo sapiens	0-18
7792388-5	1995	Progesterone (10(-7)-10(-6) M) and dexamethasone (10(-7)-10(-6) M) inhibited basal and interleukin-1 beta-stimulated prostaglandin production, and decreased the numbers of COX-2 positive cells.	Progesterone	0-12	interleukin 1 beta	Homo sapiens	87-105
7792388-5	1995	Progesterone (10(-7)-10(-6) M) and dexamethasone (10(-7)-10(-6) M) inhibited basal and interleukin-1 beta-stimulated prostaglandin production, and decreased the numbers of COX-2 positive cells.	Dexamethasone	35-48	interleukin 1 beta	Homo sapiens	87-105
7792388-5	1995	Progesterone (10(-7)-10(-6) M) and dexamethasone (10(-7)-10(-6) M) inhibited basal and interleukin-1 beta-stimulated prostaglandin production, and decreased the numbers of COX-2 positive cells.	Prostaglandins	117-130	interleukin 1 beta	Homo sapiens	87-105
7705310-9	1994	Preincubation of alveolar macrophages for 24 hr with silica-primed human alveolar macrophages for enhanced interleukin-1 beta (IL-1 beta) release stimulated by endotoxin (LPS) that was dose dependent.	Silicon Dioxide	53-59	interleukin 1 beta	Homo sapiens	107-125
7705310-9	1994	Preincubation of alveolar macrophages for 24 hr with silica-primed human alveolar macrophages for enhanced interleukin-1 beta (IL-1 beta) release stimulated by endotoxin (LPS) that was dose dependent.	Silicon Dioxide	53-59	interleukin 1 beta	Homo sapiens	127-136
7843804-0	1994	Role of oxygen radicals and IL-6 in IL-1-dependent cartilage matrix degradation.	Reactive Oxygen Species	8-23	interleukin 1 beta	Homo sapiens	36-40
7843804-3	1994	Superoxide dismutase, catalase, or methionine all significantly inhibited cartilage matrix degradation both in IL-1 beta-stimulated and unstimulated experimental conditions.	Methionine	35-45	interleukin 1 beta	Homo sapiens	111-120
7843804-5	1994	The addition of methionine significantly inhibited collagenase activity produced in the culture supernatants of chondrocytes stimulated with IL-1 beta.	Methionine	16-26	interleukin 1 beta	Homo sapiens	141-150
7843804-7	1994	IL-6 inhibited superoxide production by chondrocytes both in IL-1 beta-stimulated or unstimulated conditions.	Superoxides	15-25	interleukin 1 beta	Homo sapiens	61-70
7843804-8	1994	These results suggest that oxygen radicals are involved in cartilage matrix degradation mediated by both paracrine and autocrine IL-1 mechanisms and that oxygen radical-mediated activation of collagenase in chondrocytes may explain the mechanisms of how oxygen radicals are involved in cartilage matrix degradation.	Reactive Oxygen Species	27-42	interleukin 1 beta	Homo sapiens	129-133
7843804-8	1994	These results suggest that oxygen radicals are involved in cartilage matrix degradation mediated by both paracrine and autocrine IL-1 mechanisms and that oxygen radical-mediated activation of collagenase in chondrocytes may explain the mechanisms of how oxygen radicals are involved in cartilage matrix degradation.	Reactive Oxygen Species	27-41	interleukin 1 beta	Homo sapiens	129-133
7965120-0	1994	Hemoglobin augmentation of interleukin-1 beta-induced production of nitric oxide in smooth-muscle cells.	Nitric Oxide	68-80	interleukin 1 beta	Homo sapiens	27-45
7965120-4	1994	Certain of these cytokines, including interleukin-1 beta (IL-1 beta), are capable of increasing nitric oxide (NO) production via the inducible form of nitric oxide synthase (NOS), and excessive NO production under these conditions may contribute to cellular dysfunction.	Nitric Oxide	96-108	interleukin 1 beta	Homo sapiens	38-56
7965120-4	1994	Certain of these cytokines, including interleukin-1 beta (IL-1 beta), are capable of increasing nitric oxide (NO) production via the inducible form of nitric oxide synthase (NOS), and excessive NO production under these conditions may contribute to cellular dysfunction.	Nitric Oxide	96-108	interleukin 1 beta	Homo sapiens	58-67
7965120-13	1994	In contrast, Hb markedly augmented nitrite accumulation induced by IL-1 beta.	Nitrites	35-42	interleukin 1 beta	Homo sapiens	67-76
7808430-3	1994	IL-1 beta and TNF-alpha blocked 3-methylcholanthrene (3-MC)-induced EROD activity by up to 25 and 44%, respectively.	Methylcholanthrene	32-52	interleukin 1 beta	Homo sapiens	0-9
7892511-1	1994	The purpose of this study was to determine the mechanism of enhanced prostaglandin synthesis in amnion-derived WISH cell cultures when stimulated by interleukin-1 beta (IL-1 beta).	Prostaglandins	69-82	interleukin 1 beta	Homo sapiens	149-167
7892511-1	1994	The purpose of this study was to determine the mechanism of enhanced prostaglandin synthesis in amnion-derived WISH cell cultures when stimulated by interleukin-1 beta (IL-1 beta).	Prostaglandins	69-82	interleukin 1 beta	Homo sapiens	169-178
7892511-4	1994	IL-1 beta enhanced the production of PGE2 in a dose- and time-dependent manner with enhanced production detectable by 2 h following exposure.	Dinoprostone	37-41	interleukin 1 beta	Homo sapiens	0-9
7949102-10	1994	Cycloheximide had no effect on PTX3 induction in U937 cells, but was inhibitory on monocytes exposed to LPS or IL-1 beta.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	111-120
7947945-7	1994	The ATP-elicited release of glycosaminoglycans was also enhanced by interleukin 1 beta, tumour necrosis factor alpha, and transforming growth factor-beta, although only high concentrations of the latter were effective.	Adenosine Triphosphate	4-7	interleukin 1 beta	Homo sapiens	68-116
7947945-7	1994	The ATP-elicited release of glycosaminoglycans was also enhanced by interleukin 1 beta, tumour necrosis factor alpha, and transforming growth factor-beta, although only high concentrations of the latter were effective.	Glycosaminoglycans	28-46	interleukin 1 beta	Homo sapiens	68-116
7947945-9	1994	The enhancement of the response to ATP by interleukin 1 beta and tumour necrosis factor alpha suggests an additional mechanism whereby these cytokines can promote cartilage resorption.	Adenosine Triphosphate	35-38	interleukin 1 beta	Homo sapiens	42-93
7957941-5	1994	In contrast, the secretion of beta/A4-containing epitope was not affected by short-term IL-1 beta stimulation; however, long-term IL-1 beta treatment decreased the amount of beta/A4-containing epitope secreted from the cells.	beta/a4	30-37	interleukin 1 beta	Homo sapiens	130-139
7957941-5	1994	In contrast, the secretion of beta/A4-containing epitope was not affected by short-term IL-1 beta stimulation; however, long-term IL-1 beta treatment decreased the amount of beta/A4-containing epitope secreted from the cells.	beta/a4	174-181	interleukin 1 beta	Homo sapiens	130-139
7927746-3	1994	In the present study, we analyzed the regulation of the Mycoplasma arthritidis-derived superantigen (MAM)-induced IL-1 beta and TNF-alpha gene expression by studying the effects of two different anti-inflammatory agents: dexamethasone (DEX) and the T-cell-derived cytokine IL-4.	Dexamethasone	221-234	interleukin 1 beta	Homo sapiens	114-123
7927746-4	1994	Both agents contributed to the downregulation of MAM-induced IL-1 beta and TNF-alpha gene expression.	6-O-monoacetylmorphine	49-52	interleukin 1 beta	Homo sapiens	61-70
7829998-4	1994	When TNF-alpha was added simultaneously with IL-1 beta, the highest concentration of TNF-alpha (10(6) U/l) enhanced the inhibition of Tg and cAMP induced by IL-1 beta (1-10(5) U/l).	Cyclic AMP	141-145	interleukin 1 beta	Homo sapiens	45-54
7829998-4	1994	When TNF-alpha was added simultaneously with IL-1 beta, the highest concentration of TNF-alpha (10(6) U/l) enhanced the inhibition of Tg and cAMP induced by IL-1 beta (1-10(5) U/l).	Cyclic AMP	141-145	interleukin 1 beta	Homo sapiens	157-166
7829998-6	1994	IFN-gamma (10(4) U/l) added together with IL-1 beta in lower concentrations (1-10(2) U/l) stimulated cAMP production, while at high concentrations of IL-1 beta (10(5) U/l), IFN-gamma enhanced the inhibitory influence of IL-1 beta on Tg production.	Cyclic AMP	101-105	interleukin 1 beta	Homo sapiens	42-51
7930619-6	1994	The observed inhibitory effects were not restricted to endotoxin-induced cytokine production, because adenosine also inhibited TNF-alpha production by monocytes stimulated with the proinflammatory cytokine IL-1 beta.	Adenosine	102-111	interleukin 1 beta	Homo sapiens	206-215
7930619-8	1994	In contrast, adenosine enhanced production of IL-6 and IL-8 by monocytes stimulated with IL-1 beta.	Adenosine	13-22	interleukin 1 beta	Homo sapiens	89-98
7531790-1	1994	Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) triggers the expression of a macrophage-type of nitric oxide (NO) synthase and the subsequent increase of cellular concentration of cGMP and nitrite production.	Cyclic GMP	215-219	interleukin 1 beta	Homo sapiens	52-70
7531790-1	1994	Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) triggers the expression of a macrophage-type of nitric oxide (NO) synthase and the subsequent increase of cellular concentration of cGMP and nitrite production.	Cyclic GMP	215-219	interleukin 1 beta	Homo sapiens	72-81
7824567-3	1994	We report here that microinjections of 5 and 30 ng (286 fmol and 1.71 pmol) of recombinant human IL-1 beta in the ventromedial nucleus of the hypothalamus (VMH) of adult male rats time- and dose-dependently induce anorexia and weight loss in two experimental paradigms: rats allowed free-access to food and water and food-restricted rats trained to press a lever for food on a fixed ratio 10 schedule.	Water	307-312	interleukin 1 beta	Homo sapiens	97-106
7846335-9	1994	No correlation was found between TNF-alpha and NO/nitrite, whereas a weak but significant correlation was found between NO/nitrite and concentrations of another cytokine, interleukin-1 beta (IL-1 beta).	Nitrites	123-130	interleukin 1 beta	Homo sapiens	171-189
7846335-9	1994	No correlation was found between TNF-alpha and NO/nitrite, whereas a weak but significant correlation was found between NO/nitrite and concentrations of another cytokine, interleukin-1 beta (IL-1 beta).	Nitrites	123-130	interleukin 1 beta	Homo sapiens	191-200
7980390-7	1994	In addition, TNF-alpha and IL-1 beta stimulated [3H]thymidine incorporation in Niemann-Pick fibroblasts, as in normal cells.	Tritium	49-51	interleukin 1 beta	Homo sapiens	27-36
7980390-7	1994	In addition, TNF-alpha and IL-1 beta stimulated [3H]thymidine incorporation in Niemann-Pick fibroblasts, as in normal cells.	Thymidine	52-61	interleukin 1 beta	Homo sapiens	27-36
7524364-1	1994	Modulation of the beta-adrenergic control of the cardiac L-type Ca2+ current (ICa) by human recombinant interleukin-1 beta (IL-1) was examined in guinea pig ventricular myocytes using the whole cell voltage-clamp technique.	isocyanic acid	78-81	interleukin 1 beta	Homo sapiens	104-122
7524364-1	1994	Modulation of the beta-adrenergic control of the cardiac L-type Ca2+ current (ICa) by human recombinant interleukin-1 beta (IL-1) was examined in guinea pig ventricular myocytes using the whole cell voltage-clamp technique.	isocyanic acid	78-81	interleukin 1 beta	Homo sapiens	124-128
7524364-4	1994	However, when cells were pretreated with 1 ng/ml IL-1 and then exposed to acid media, beta-responsiveness was significantly increased compared with untreated cells.	acid media	74-84	interleukin 1 beta	Homo sapiens	49-53
7524364-6	1994	The enhanced beta-responsiveness produced by IL-1 was eliminated by adding amiloride to block Na+/H+ exchange or protein kinase C inhibitors staurosporine (10 nM) and calphostin C (50 nM).	Amiloride	75-84	interleukin 1 beta	Homo sapiens	45-49
7524364-6	1994	The enhanced beta-responsiveness produced by IL-1 was eliminated by adding amiloride to block Na+/H+ exchange or protein kinase C inhibitors staurosporine (10 nM) and calphostin C (50 nM).	Staurosporine	141-154	interleukin 1 beta	Homo sapiens	45-49
7524364-6	1994	The enhanced beta-responsiveness produced by IL-1 was eliminated by adding amiloride to block Na+/H+ exchange or protein kinase C inhibitors staurosporine (10 nM) and calphostin C (50 nM).	calphostin C	167-179	interleukin 1 beta	Homo sapiens	45-49
7926489-2	1994	IL-1 beta suppresses norepinephrine release from the myenteric plexus, but the effect of IL-6 is unknown.	Norepinephrine	21-35	interleukin 1 beta	Homo sapiens	0-9
7926489-3	1994	Therefore, we investigated the effects of IL-6 alone and in combination with IL-1 beta on norepinephrine release.	Norepinephrine	90-104	interleukin 1 beta	Homo sapiens	77-86
7926489-6	1994	However, IL-6 (10 ng/mL) plus a subthreshold concentration of human recombinant IL-1 beta significantly suppressed 3H release, and this was abolished by adding anti-IL-6 antibody or an IL-1 receptor antagonist.	Tritium	115-117	interleukin 1 beta	Homo sapiens	80-89
7926489-8	1994	Furthermore, there is synergism between IL-1 beta and IL-6 resulting in suppression of norepinephrine release.	Norepinephrine	87-101	interleukin 1 beta	Homo sapiens	40-49
7890309-5	1994	Furthermore, we found that epsilon BP potentiated IL-1 production by monocytes in a manner that was inhibitable by the saccharide ligand of epsilon BP.	Carbohydrates	119-129	interleukin 1 beta	Homo sapiens	50-54
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Asparagine	53-56	interleukin 1 beta	Homo sapiens	121-130
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Aspartic Acid	57-60	interleukin 1 beta	Homo sapiens	101-119
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Aspartic Acid	57-60	interleukin 1 beta	Homo sapiens	121-130
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	lys-oh	61-67	interleukin 1 beta	Homo sapiens	101-119
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	lys-oh	61-67	interleukin 1 beta	Homo sapiens	121-130
7525928-0	1994	Effects of prostacyclin analogs on the synthesis of tissue factor, tumor necrosis factor-alpha and interleukin-1 beta in human monocytic THP-1 cells.	Epoprostenol	11-23	interleukin 1 beta	Homo sapiens	99-117
7525928-6	1994	Iloprost and cicaprost were less potent in inhibiting the synthesis of interleukin-1 beta (50% inhibition, 50-100 nM).	Iloprost	0-8	interleukin 1 beta	Homo sapiens	71-89
7525928-6	1994	Iloprost and cicaprost were less potent in inhibiting the synthesis of interleukin-1 beta (50% inhibition, 50-100 nM).	cicaprost	13-22	interleukin 1 beta	Homo sapiens	71-89
7525928-7	1994	Cicaprost inhibited lipopolysaccharide-induced increases in mRNA levels for TF, tumor necrosis factor-alpha and interleukin-1 beta; differential potency was again observed.	cicaprost	0-9	interleukin 1 beta	Homo sapiens	112-130
7523800-0	1994	Modulation of IL-8, IL-1 beta, and G-CSF secretion by all-trans retinoic acid in acute promyelocytic leukemia.	Tretinoin	64-77	interleukin 1 beta	Homo sapiens	20-29
7523800-9	1994	Interestingly, the increase of IL-1 beta and G-CSF production in the presence of ATRA was highly correlated to an increase in APL cell count in vitro and in vivo hyperleukocytosis, resulting in fatal outcome.	Tretinoin	81-85	interleukin 1 beta	Homo sapiens	31-40
7523818-2	1994	The authors investigated the localization of IL-1 beta messenger RNA (mRNA) in the maxillary sinus mucosa of patients with chronic sinusitis, using digoxigenin-labeled oligonucleotide probes.	Digoxigenin	148-159	interleukin 1 beta	Homo sapiens	45-54
7523818-2	1994	The authors investigated the localization of IL-1 beta messenger RNA (mRNA) in the maxillary sinus mucosa of patients with chronic sinusitis, using digoxigenin-labeled oligonucleotide probes.	Oligonucleotides	168-183	interleukin 1 beta	Homo sapiens	45-54
7837816-1	1995	We evaluated the in vitro proliferative response to exogenous IL-1 beta in terms of tritiated thymidine (3H-TdR) incorporation in leukemic cells obtained from 119 patients with various types of acute leukemia.	Tritiated thymidine	84-103	interleukin 1 beta	Homo sapiens	62-71
7837816-1	1995	We evaluated the in vitro proliferative response to exogenous IL-1 beta in terms of tritiated thymidine (3H-TdR) incorporation in leukemic cells obtained from 119 patients with various types of acute leukemia.	Tritium	105-107	interleukin 1 beta	Homo sapiens	62-71
7476567-1	1995	Previous findings provided evidence that bacterial lipopolysaccharide (LPS)-activated human monocytes are able to upregulate autologous polymorphonuclear (PMN) phagocytic ability via cell-to-cell contact mechanisms mediated by membrane (m)-associated cytokines (CKs), such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 alpha, IL-1 beta, IL-6 and IL-8.	bacterial lipopolysaccharide	41-69	interleukin 1 beta	Homo sapiens	338-347
7792388-0	1995	Interleukin-1 beta-stimulated PGE2 production from early first trimester human decidual cells is inhibited by dexamethasone and progesterone.	Dinoprostone	30-34	interleukin 1 beta	Homo sapiens	0-18
7502507-4	1995	Liberation of cytokines (IL-1, IL-6, IL-8) stimulates prostanoid synthesis in the decidua and amnion, as well as migration of granulocytes into the cervix.	Prostaglandins	54-64	interleukin 1 beta	Homo sapiens	25-29
7810657-3	1994	An anti-IL-1 beta completely blocked the increase in tritiated thymidine uptake, whereas an IL-1 receptor antagonist human recombinant blocked it partially.	Tritiated thymidine	53-72	interleukin 1 beta	Homo sapiens	8-17
7528007-0	1994	Dexamethasone differentially affects interleukin 1 beta- and cyclic AMP-induced nitric oxide synthase mRNA expression in renal mesangial cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	37-55
7528007-3	1994	We examined whether dexamethasone differentially affects iNOS induction in response to IL-1 beta and a membrane-permeable cAMP analogue, N6,O-2"-dibutyryladenosine 3",5"-phosphate (Bt2cAMP).	Dexamethasone	20-33	interleukin 1 beta	Homo sapiens	87-96
7528007-4	1994	Nanomolar concentrations of dexamethasone suppress IL-1 beta- as well as Bt2cAMP-induced iNOS protein expression and production of nitrite, the stable end product of nitric oxide (NO) formation.	Dexamethasone	28-41	interleukin 1 beta	Homo sapiens	51-60
7804447-2	1994	We have reported in a preliminary fashion that interleukin 1 beta (IL-1 beta) and transforming growth factor-beta (TGF-beta) increased the rate of [35S]sulfate incorporation into proteoglycans two to five times the control in culture of retro-ocular tissue fibroblasts.	Sulfur-35	148-151	interleukin 1 beta	Homo sapiens	47-65
7804447-2	1994	We have reported in a preliminary fashion that interleukin 1 beta (IL-1 beta) and transforming growth factor-beta (TGF-beta) increased the rate of [35S]sulfate incorporation into proteoglycans two to five times the control in culture of retro-ocular tissue fibroblasts.	Sulfur-35	148-151	interleukin 1 beta	Homo sapiens	67-76
7804447-2	1994	We have reported in a preliminary fashion that interleukin 1 beta (IL-1 beta) and transforming growth factor-beta (TGF-beta) increased the rate of [35S]sulfate incorporation into proteoglycans two to five times the control in culture of retro-ocular tissue fibroblasts.	Sulfates	152-159	interleukin 1 beta	Homo sapiens	47-65
7804447-2	1994	We have reported in a preliminary fashion that interleukin 1 beta (IL-1 beta) and transforming growth factor-beta (TGF-beta) increased the rate of [35S]sulfate incorporation into proteoglycans two to five times the control in culture of retro-ocular tissue fibroblasts.	Sulfates	152-159	interleukin 1 beta	Homo sapiens	67-76
7804447-7	1994	Disaccharide analysis by HPLC after chondroitin sulfate ABC digestion revealed that glycosaminoglycan mainly contains monosulfated chondroitin disaccharides and that oversulfation was not observed under the influence of IL-1 beta or TGF-beta, ruling out (d).	Disaccharides	0-12	interleukin 1 beta	Homo sapiens	220-229
7804447-8	1994	The capacity to synthesize glycosaminoglycan chain in the presence of an artifical acceptor of chain elongation, beta-D-xylodide, was increased significantly by IL-1 beta but not obviously so by TGF-beta.	Glycosaminoglycans	27-44	interleukin 1 beta	Homo sapiens	161-170
7804447-8	1994	The capacity to synthesize glycosaminoglycan chain in the presence of an artifical acceptor of chain elongation, beta-D-xylodide, was increased significantly by IL-1 beta but not obviously so by TGF-beta.	beta-d-xylodide	113-128	interleukin 1 beta	Homo sapiens	161-170
7877083-2	1994	The purpose of this study was to examine whether prostaglandin E2 (PGE2), which is produced in abundance from HGF after stimulation with interleukin (IL)-1 beta or tumor necrosis factor-alpha (TNF-alpha), could regulate IL-6 production by HGF.	Dinoprostone	49-65	interleukin 1 beta	Homo sapiens	137-160
7877083-2	1994	The purpose of this study was to examine whether prostaglandin E2 (PGE2), which is produced in abundance from HGF after stimulation with interleukin (IL)-1 beta or tumor necrosis factor-alpha (TNF-alpha), could regulate IL-6 production by HGF.	Dinoprostone	67-71	interleukin 1 beta	Homo sapiens	137-160
7877083-4	1994	IL-6 secretion from either IL-1 beta- or TNF-alpha-stimulated HGF was enhanced by the inhibition of PGE2 synthesis with indomethacin.	Dinoprostone	100-104	interleukin 1 beta	Homo sapiens	27-36
7877083-4	1994	IL-6 secretion from either IL-1 beta- or TNF-alpha-stimulated HGF was enhanced by the inhibition of PGE2 synthesis with indomethacin.	Indomethacin	120-132	interleukin 1 beta	Homo sapiens	27-36
7808430-3	1994	IL-1 beta and TNF-alpha blocked 3-methylcholanthrene (3-MC)-induced EROD activity by up to 25 and 44%, respectively.	Methylcholanthrene	54-58	interleukin 1 beta	Homo sapiens	0-9
7808430-8	1994	Our results demonstrate that IL-1 beta, TNF-alpha, and IFNs antagonized PAH-mediated induction of CYP1A gene expression in human hepatocytes.	Polycyclic Aromatic Hydrocarbons	72-75	interleukin 1 beta	Homo sapiens	29-38
7892510-9	1994	The activity present in one of these was synergistic with interleukin-1 beta (IL-1 beta) in stimulating amnion cell PGE2 production and was found to contain mainly transforming growth factor-alpha (TGF-alpha) immunoreactivity.	Dinoprostone	116-120	interleukin 1 beta	Homo sapiens	58-76
7892510-9	1994	The activity present in one of these was synergistic with interleukin-1 beta (IL-1 beta) in stimulating amnion cell PGE2 production and was found to contain mainly transforming growth factor-alpha (TGF-alpha) immunoreactivity.	Dinoprostone	116-120	interleukin 1 beta	Homo sapiens	78-87
7892510-11	1994	The PGE2-stimulatory activity present in the other peak contained IL-1 beta, epidermal growth factor (EGF), and tumor necrosis factor-alpha (TNF-alpha).	Dinoprostone	4-8	interleukin 1 beta	Homo sapiens	66-75
7741042-1	1994	CGP 47969A is a novel piperazine derivative that inhibits the synthesis of inflammatory cytokines, such as interleukin-1 alpha (IL-1), IL-1 beta and tumor necrosis factor alpha (TNF), in human monocytes stimulated with lipopolysaccharide (LPS), zymosan or IL-1 itself.	Piperazine	22-32	interleukin 1 beta	Homo sapiens	128-132
7741042-1	1994	CGP 47969A is a novel piperazine derivative that inhibits the synthesis of inflammatory cytokines, such as interleukin-1 alpha (IL-1), IL-1 beta and tumor necrosis factor alpha (TNF), in human monocytes stimulated with lipopolysaccharide (LPS), zymosan or IL-1 itself.	Piperazine	22-32	interleukin 1 beta	Homo sapiens	135-144
7741042-1	1994	CGP 47969A is a novel piperazine derivative that inhibits the synthesis of inflammatory cytokines, such as interleukin-1 alpha (IL-1), IL-1 beta and tumor necrosis factor alpha (TNF), in human monocytes stimulated with lipopolysaccharide (LPS), zymosan or IL-1 itself.	Piperazine	22-32	interleukin 1 beta	Homo sapiens	135-139
7526712-0	1994	IL-1 inhibits beta-adrenergic control of cardiac calcium current: role of L-arginine/nitric oxide pathway.	Calcium	49-56	interleukin 1 beta	Homo sapiens	0-4
7526712-0	1994	IL-1 inhibits beta-adrenergic control of cardiac calcium current: role of L-arginine/nitric oxide pathway.	Arginine	74-84	interleukin 1 beta	Homo sapiens	0-4
7526712-0	1994	IL-1 inhibits beta-adrenergic control of cardiac calcium current: role of L-arginine/nitric oxide pathway.	Nitric Oxide	85-97	interleukin 1 beta	Homo sapiens	0-4
7526712-1	1994	Modulation of the beta-adrenergic control of cardiac L-type Ca2+ current (Ica) by human recombinant interleukin-1 beta (IL-1) was examined in adult guinea pig ventricular myocytes using the whole cell voltage-clamp technique.	isocyanic acid	74-77	interleukin 1 beta	Homo sapiens	100-118
7526712-1	1994	Modulation of the beta-adrenergic control of cardiac L-type Ca2+ current (Ica) by human recombinant interleukin-1 beta (IL-1) was examined in adult guinea pig ventricular myocytes using the whole cell voltage-clamp technique.	isocyanic acid	74-77	interleukin 1 beta	Homo sapiens	120-124
7526712-3	1994	Isoproterenol (0.01 and 1 microM) exposed to myocytes pretreated with 1 ng/ml IL-1 evoked a significantly smaller increase in ICa density compared with control cells.	Isoproterenol	0-13	interleukin 1 beta	Homo sapiens	78-82
7526712-3	1994	Isoproterenol (0.01 and 1 microM) exposed to myocytes pretreated with 1 ng/ml IL-1 evoked a significantly smaller increase in ICa density compared with control cells.	isocyanic acid	126-129	interleukin 1 beta	Homo sapiens	78-82
7526712-4	1994	This IL-1-mediated decrease in beta-responsiveness was usually observed with pretreatment periods of &gt; 1 h and varied as a function of the L-arginine concentration of the pretreatment medium.	Arginine	142-152	interleukin 1 beta	Homo sapiens	5-9
7536063-0	1994	Interleukin-1 beta induces cyclic AMP formation in isolated human osteoblasts: a signalling mechanism that is not related to enhanced prostaglandin formation.	Cyclic AMP	27-37	interleukin 1 beta	Homo sapiens	0-18
7536063-5	1994	IL-1 beta, at and above 0.3 pM, dose dependently stimulated PGE2 formation in isolated human osteoblasts, with half maximal stimulation, EC50, at 3 pM.	Dinoprostone	60-64	interleukin 1 beta	Homo sapiens	0-9
7536063-7	1994	The time-course for IL-1 beta-induced PGE2 formation was similar to that of forskolin, with a significant increase in the formation of PGE2 seen after 1 h. In contrast, A23187-induced PGE2 formation was seen within minutes.	Dinoprostone	38-42	interleukin 1 beta	Homo sapiens	20-29
7536063-7	1994	The time-course for IL-1 beta-induced PGE2 formation was similar to that of forskolin, with a significant increase in the formation of PGE2 seen after 1 h. In contrast, A23187-induced PGE2 formation was seen within minutes.	Dinoprostone	135-139	interleukin 1 beta	Homo sapiens	20-29
7536063-7	1994	The time-course for IL-1 beta-induced PGE2 formation was similar to that of forskolin, with a significant increase in the formation of PGE2 seen after 1 h. In contrast, A23187-induced PGE2 formation was seen within minutes.	Calcimycin	169-175	interleukin 1 beta	Homo sapiens	20-29
7536063-7	1994	The time-course for IL-1 beta-induced PGE2 formation was similar to that of forskolin, with a significant increase in the formation of PGE2 seen after 1 h. In contrast, A23187-induced PGE2 formation was seen within minutes.	Dinoprostone	135-139	interleukin 1 beta	Homo sapiens	20-29
7536063-8	1994	IL-1 beta stimulated the accumulation of cyclic AMP in isolated human osteoblasts incubated for 15 min.	Cyclic AMP	41-51	interleukin 1 beta	Homo sapiens	0-9
7536063-11	1994	We conclude that IL-1 beta enhances the formation of cyclic AMP as well as PGE2 in primary cultures of isolated human osteoblasts.	Cyclic AMP	53-63	interleukin 1 beta	Homo sapiens	17-26
7536063-11	1994	We conclude that IL-1 beta enhances the formation of cyclic AMP as well as PGE2 in primary cultures of isolated human osteoblasts.	Dinoprostone	75-79	interleukin 1 beta	Homo sapiens	17-26
7536063-12	1994	The IL-1 beta-induced cyclic AMP formation is, however, not related to the enhanced prostaglandin formation.	Cyclic AMP	22-32	interleukin 1 beta	Homo sapiens	4-13
7536063-13	1994	The findings implicate that both cyclic AMP- and PGE2-formation in osteoblasts might be involved as independent mediators of IL-1 beta-induced bone resorption.	Cyclic AMP	33-43	interleukin 1 beta	Homo sapiens	125-134
7536063-13	1994	The findings implicate that both cyclic AMP- and PGE2-formation in osteoblasts might be involved as independent mediators of IL-1 beta-induced bone resorption.	Dinoprostone	49-53	interleukin 1 beta	Homo sapiens	125-134
7858842-14	1994	This release was enhanced by treatment of either cell type with the mixture of cytokines (interleukin-1 beta , tumour necrosis factors- and interferon-gamma, 10 ng ml-1 for all).PGE2 was the principal COX metabolite released by cytokine-activated epithelial cells.	Dinoprostone	178-182	interleukin 1 beta	Homo sapiens	90-156
7981988-6	1994	The secretion of IL-1 beta by stimulated PBMNC (P = 0.008) was higher in this group and decreased significantly (P = 0.03) after a single MTX dose.	Methotrexate	138-141	interleukin 1 beta	Homo sapiens	17-26
7981988-10	1994	In conclusion, a single MTX dose may result in decreased production of IL-1 beta by PBMNC in patients with active RA.	Methotrexate	24-27	interleukin 1 beta	Homo sapiens	71-80
7868298-6	1994	For example, the IC50 for suramin inhibiting IL-1 alpha and IL-1 beta binding to soluble human IL-1 receptor were 204 microM and 186 microM, respectively.	Suramin	26-33	interleukin 1 beta	Homo sapiens	60-69
7525939-8	1994	Fast and slow inhibitory postsynaptic potentials elicited by direct stimulation of GABA interneurons in the lateral amygdala were also depressed by IL-1 beta.	gamma-Aminobutyric Acid	83-87	interleukin 1 beta	Homo sapiens	148-157
7525939-11	1994	The results show that IL-1 beta inhibits excitatory and inhibitory transmission at a presynaptic site and hyperpolarizes the membrane through an indirect action, possibly by enhancing the action of endogenous GABA in the BLA nucleus.	gamma-Aminobutyric Acid	209-213	interleukin 1 beta	Homo sapiens	22-31
7531790-1	1994	Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) triggers the expression of a macrophage-type of nitric oxide (NO) synthase and the subsequent increase of cellular concentration of cGMP and nitrite production.	Nitrites	224-231	interleukin 1 beta	Homo sapiens	52-70
7531790-1	1994	Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) triggers the expression of a macrophage-type of nitric oxide (NO) synthase and the subsequent increase of cellular concentration of cGMP and nitrite production.	Nitrites	224-231	interleukin 1 beta	Homo sapiens	72-81
7966813-13	1994	The only observed qualitative difference between aneurysmal aortic smooth muscle cells and normal aortic smooth muscle cells was the change in tissue inhibitor of metalloproteinase-1 messenger ribonucleic acid levels in response to added interleukin-1 beta.	ribonucleic	193-204	interleukin 1 beta	Homo sapiens	238-256
7844884-5	1994	Treatment of endothelial cells with either IL-1 beta or TNF-alpha under static conditions increased PAI-1, vWF and prostacyclin release, while t-PA secretion was unchanged.	Epoprostenol	115-127	interleukin 1 beta	Homo sapiens	43-52
7835945-0	1994	Pentoxifylline in vivo down-regulates the release of IL-1 beta, IL-6, IL-8 and tumour necrosis factor-alpha by human peripheral blood mononuclear cells.	Pentoxifylline	0-14	interleukin 1 beta	Homo sapiens	53-62
7835945-2	1994	There is also recent evidence that PTX may influence other inflammatory cytokines, such as interleukin-1 (IL-1) and IL-6.	Pentoxifylline	35-38	interleukin 1 beta	Homo sapiens	106-110
7835945-3	1994	Due to the therapeutic implications, the present study addressed the in vivo effects of PTX on the release of TNF-alpha, IL-1 beta, IL-6 and IL-8 by human peripheral blood mononuclear cells (PBMC).	Pentoxifylline	88-91	interleukin 1 beta	Homo sapiens	121-130
7835945-4	1994	When PBMC were obtained from healthy volunteers ingesting 5 x 400 mg PTX orally for 2 days, the ability of PBMC cultured for 24 hr to release TNF-alpha was significantly reduced, while secretion of IL-1 beta, IL-6 and IL-8 was not affected.	Pentoxifylline	69-72	interleukin 1 beta	Homo sapiens	198-207
7835945-9	1994	However, when PBMC were incubated with PTX for 24 hr, PTX removed thereafter by medium change and cells further cultured, the production not only of TNF-alpha but also of IL-1 beta, IL-6 and IL-8 was reduced, demonstrating that PTX exerts diverse (inhibitory) effects on cytokine release by PBMC.	Pentoxifylline	39-42	interleukin 1 beta	Homo sapiens	171-180
7835945-9	1994	However, when PBMC were incubated with PTX for 24 hr, PTX removed thereafter by medium change and cells further cultured, the production not only of TNF-alpha but also of IL-1 beta, IL-6 and IL-8 was reduced, demonstrating that PTX exerts diverse (inhibitory) effects on cytokine release by PBMC.	Pentoxifylline	54-57	interleukin 1 beta	Homo sapiens	171-180
7835945-9	1994	However, when PBMC were incubated with PTX for 24 hr, PTX removed thereafter by medium change and cells further cultured, the production not only of TNF-alpha but also of IL-1 beta, IL-6 and IL-8 was reduced, demonstrating that PTX exerts diverse (inhibitory) effects on cytokine release by PBMC.	Pentoxifylline	54-57	interleukin 1 beta	Homo sapiens	171-180
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Valine	29-32	interleukin 1 beta	Homo sapiens	101-119
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Valine	29-32	interleukin 1 beta	Homo sapiens	121-130
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Glutamine	33-36	interleukin 1 beta	Homo sapiens	101-119
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Glutamine	33-36	interleukin 1 beta	Homo sapiens	121-130
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Glycine	37-40	interleukin 1 beta	Homo sapiens	101-119
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Glycine	37-40	interleukin 1 beta	Homo sapiens	121-130
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Glutamic Acid	41-44	interleukin 1 beta	Homo sapiens	101-119
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Glutamic Acid	41-44	interleukin 1 beta	Homo sapiens	121-130
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Glutamic Acid	45-48	interleukin 1 beta	Homo sapiens	101-119
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Glutamic Acid	45-48	interleukin 1 beta	Homo sapiens	121-130
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Serine	49-52	interleukin 1 beta	Homo sapiens	101-119
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Serine	49-52	interleukin 1 beta	Homo sapiens	121-130
7534472-1	1994	A T-cell stimulating peptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH, the 163-171 fragment epitope of interleukin-1 beta (IL-1 beta), has been synthesized in solution phase and purified by reverse-phase high-performance liquid chromatography (RP-HPLC).	Asparagine	53-56	interleukin 1 beta	Homo sapiens	101-119
7927669-3	1994	IL-1 beta/albumin ratios were elevated only in CAD+PA, while no TNF bioactivity was detected in BAL fluids.	cad+pa	47-53	interleukin 1 beta	Homo sapiens	0-9
7861699-8	1994	Furthermore, increasing intracellular cAMP and activating PKA attenuated basal MCP-1 mRNA levels by 82% and blocked IL-1 induced MCP-1 expression by 88%.	Cyclic AMP	38-42	interleukin 1 beta	Homo sapiens	116-120
7861699-10	1994	The structurally distinct protein tyrosine kinase (PTK) inhibitors genistein, herbimycin A, and tyrphostin each caused a dose-dependent inhibition of the effects of IL-1 on mesangial MCP-1 activity.	Genistein	67-76	interleukin 1 beta	Homo sapiens	165-169
7861699-10	1994	The structurally distinct protein tyrosine kinase (PTK) inhibitors genistein, herbimycin A, and tyrphostin each caused a dose-dependent inhibition of the effects of IL-1 on mesangial MCP-1 activity.	herbimycin	78-90	interleukin 1 beta	Homo sapiens	165-169
7861699-10	1994	The structurally distinct protein tyrosine kinase (PTK) inhibitors genistein, herbimycin A, and tyrphostin each caused a dose-dependent inhibition of the effects of IL-1 on mesangial MCP-1 activity.	Tyrphostins	96-106	interleukin 1 beta	Homo sapiens	165-169
7526148-3	1994	Among these antirheumatic drugs, gold sodium thiomalate significantly inhibited intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on vascular endothelial cells and suppressed cellular binding between human monocytic cell lines, including U937 and HL-60 cells, and interleukin-1 beta-stimulated vascular endothelial cells.	Gold Sodium Thiomalate	33-55	interleukin 1 beta	Homo sapiens	297-315
7824084-10	1994	Indomethacin, an inhibitor of prostaglandin (PG) synthesis, has been shown to block both the induction of CRH secretion by IL-1 beta from hypothalamic explants, as well as the ACTH response to intravenous IL-1 beta.	Prostaglandins	45-47	interleukin 1 beta	Homo sapiens	123-132
7824084-11	1994	Thus, indomethacin was used to determine whether PGs are mediators of the ACTH response to IL-1 beta delivered into the ME.	Phosphatidylglycerols	49-52	interleukin 1 beta	Homo sapiens	91-100
7824084-0	1994	Prostaglandins mediate the ACTH response to interleukin-1-beta instilled into the hypothalamic median eminence.	Prostaglandins	0-14	interleukin 1 beta	Homo sapiens	44-62
7824084-10	1994	Indomethacin, an inhibitor of prostaglandin (PG) synthesis, has been shown to block both the induction of CRH secretion by IL-1 beta from hypothalamic explants, as well as the ACTH response to intravenous IL-1 beta.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	123-132
7824084-10	1994	Indomethacin, an inhibitor of prostaglandin (PG) synthesis, has been shown to block both the induction of CRH secretion by IL-1 beta from hypothalamic explants, as well as the ACTH response to intravenous IL-1 beta.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	205-214
7932530-2	1994	These isothiazolones have been shown to exhibit potent, dose-dependent inhibition of IL-1 beta-induced breakdown of proteoglycan in a cartilage organ culture assay.	isothiazolones	6-20	interleukin 1 beta	Homo sapiens	85-94
8083217-1	1994	Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA.	Tretinoin	0-13	interleukin 1 beta	Homo sapiens	160-169
8083217-1	1994	Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA.	Tretinoin	15-17	interleukin 1 beta	Homo sapiens	160-169
7940896-0	1994	Effect of cyclosporine on interleukin 1(beta) and immunoglobulin production in vitro.	Cyclosporine	10-22	interleukin 1 beta	Homo sapiens	26-45
7522054-1	1994	Human articular chondrocytes can be induced by IL-1 beta, TNF-alpha or LPS to release high levels of nitric oxide.	Nitric Oxide	101-113	interleukin 1 beta	Homo sapiens	47-56
8083217-7	1994	When translation is blocked, e.g. by cycloheximide, expression of IL-1 beta mRNA is superinduced by 2 orders of magnitude.	Cycloheximide	37-50	interleukin 1 beta	Homo sapiens	66-75
8077674-11	1994	It seems that melatonin activates monocytes through protein kinase C. These data suggest that melatonin activates monocytes and induces their cytotoxic properties, along with the IL-1 secretion.	Melatonin	14-23	interleukin 1 beta	Homo sapiens	179-183
8083217-12	1994	This regulation is specific for RA: when induced by phorbol ester, IL-1 beta gene expression is also superinduced by cycloheximide but that response is accompanied by enhanced mRNA stability.	Phorbol Esters	52-65	interleukin 1 beta	Homo sapiens	67-76
8083217-12	1994	This regulation is specific for RA: when induced by phorbol ester, IL-1 beta gene expression is also superinduced by cycloheximide but that response is accompanied by enhanced mRNA stability.	Cycloheximide	117-130	interleukin 1 beta	Homo sapiens	67-76
8077670-2	1994	The observation that calcium ionophores, but not a variety of physiologic receptor-mediated agonists, can mimic bradykinin in its synergy with IL-1 led us to hypothesize that the ability of bradykinin to induce prostanoid synthesis was a result of its selective ability (among physiologic agonists) to raise the cytosolic free ionized calcium concentration ([Ca2+]i) levels of synovial cells.	Calcium	21-28	interleukin 1 beta	Homo sapiens	143-147
8077674-11	1994	It seems that melatonin activates monocytes through protein kinase C. These data suggest that melatonin activates monocytes and induces their cytotoxic properties, along with the IL-1 secretion.	Melatonin	94-103	interleukin 1 beta	Homo sapiens	179-183
8077670-3	1994	Extending this hypothesis, it follows that the relative potency of an agonist in inducing PGE2 production from IL-1-treated cells should be dependent on its ability to raise [Ca2+]i.	Dinoprostone	90-94	interleukin 1 beta	Homo sapiens	111-115
8077670-6	1994	Furthermore, the relative specificity and potency of the PGE2 response of bradykinin in IL-1-treated cells was paralleled, in resting cells, by a similar pattern in the [Ca2+]i response.	Dinoprostone	57-61	interleukin 1 beta	Homo sapiens	88-92
8080039-3	1994	15(S)-HETE is rapidly esterified into PMN phospholipids, and we report that 15-(S)-HETE-remodeled PMN displayed blunted adhesion to, and migration across, human endothelial cells that had been activated with either interleukin-1 beta or tumor necrosis factor-alpha Several lines of evidence suggested that 15(S)-HETE inhibited PMN transmigration by attenuating PMN responsiveness to endothelial cell-derived platelet-activating factor (PAF).	Hydroxyeicosatetraenoic Acids	5-10	interleukin 1 beta	Homo sapiens	215-264
8077670-9	1994	However, this effect is not enough, in and of itself, to induce prostanoid synthesis; the concomitant induction by IL-1 of a PG-generating enzyme is also required.	Prostaglandins	125-127	interleukin 1 beta	Homo sapiens	115-119
8077674-2	1994	Above the activation threshold of 5 x 10(-11) M, melatonin was able to induce the cytotoxicity of human monocytes, the secretion of IL-1, and the production of reactive oxygen intermediates.	Melatonin	49-58	interleukin 1 beta	Homo sapiens	132-136
8077674-4	1994	Indeed, below their respective monocyte activation threshold (5 x 10(-11) M and 0.625 ng/ml), melatonin (10(-12) M) in association with LPS (0.2 ng/ml) was able to induce cytotoxicity, IL-1 secretion, and reactive oxygen intermediates production.	Melatonin	94-103	interleukin 1 beta	Homo sapiens	185-189
8077674-8	1994	However, when the cells were first activated by melatonin (10(-12) M), and then 8 h later by LPS (0.25 ng/ml), IL-1 secretion and monocyte cytotoxicity were observed.	Melatonin	48-57	interleukin 1 beta	Homo sapiens	111-115
8077674-9	1994	Above its monocyte activation threshold, melatonin induces both cell-associated IL-1 alpha and IL-1 beta activities.	Melatonin	41-50	interleukin 1 beta	Homo sapiens	95-104
8093049-5	1994	When mesangial cells were stimulated by IL-1 beta in the presence of heparin, transin expression was markedly suppressed in a dose-dependent manner.	Heparin	69-76	interleukin 1 beta	Homo sapiens	40-49
8063416-2	1994	PBMC and Mphi from all these donor groups secreted increased levels of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in response to stimulation with formalin-killed spherules (FKS), as measured by enzyme-linked immunosorbent assays.	Formaldehyde	170-178	interleukin 1 beta	Homo sapiens	100-118
8069926-4	1994	In this report, we show that the IFN-gamma-dependent inhibition of IL-8 release by PMN stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF), and/or interleukin-1 beta (IL-1 beta), but not with Y-IgG, is a transient phenomenon.	y-igg	210-215	interleukin 1 beta	Homo sapiens	165-183
8069926-4	1994	In this report, we show that the IFN-gamma-dependent inhibition of IL-8 release by PMN stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF), and/or interleukin-1 beta (IL-1 beta), but not with Y-IgG, is a transient phenomenon.	y-igg	210-215	interleukin 1 beta	Homo sapiens	185-194
7835824-0	1994	Interleukin-1 beta (IL-1 beta) binds to intact porcine thyroid follicles, decreases iodide uptake but has no effect on cAMP formation or proliferation.	Iodides	84-90	interleukin 1 beta	Homo sapiens	0-18
7835824-0	1994	Interleukin-1 beta (IL-1 beta) binds to intact porcine thyroid follicles, decreases iodide uptake but has no effect on cAMP formation or proliferation.	Iodides	84-90	interleukin 1 beta	Homo sapiens	20-29
7835824-2	1994	Since the results of different in vitro-studies on the effect of IL-1 on thyrocytes are controversial, our aim was to investigate the existence of specific binding sites for IL-1 beta and its influence on specific functions and growth of isolated porcine thyroid follicles ex vivo with a preserved iodide metabolism.	Iodides	298-304	interleukin 1 beta	Homo sapiens	174-183
7835824-4	1994	IL-1 beta (10 U/ml) decreased basal and TSH-stimulated iodide uptake and organification after an incubation time of 45 min to 6 h without any influence on cAMP-formation.	Thyrotropin	40-43	interleukin 1 beta	Homo sapiens	0-9
7835824-4	1994	IL-1 beta (10 U/ml) decreased basal and TSH-stimulated iodide uptake and organification after an incubation time of 45 min to 6 h without any influence on cAMP-formation.	Iodides	55-61	interleukin 1 beta	Homo sapiens	0-9
7835824-5	1994	In addition, after 40 h of incubation IL-1 beta dose-dependently increased T3-secretion, followed by a decrease during simultaneous TSH-stimulation, whereas there was no effect on T4-secretion.	Thyrotropin	132-135	interleukin 1 beta	Homo sapiens	38-47
7819135-0	1994	Activation of interleukin-1 beta gene expression during retinoic acid-induced granulocytic differentiation of promyeloid leukemia cells.	Tretinoin	56-69	interleukin 1 beta	Homo sapiens	14-32
8063416-2	1994	PBMC and Mphi from all these donor groups secreted increased levels of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in response to stimulation with formalin-killed spherules (FKS), as measured by enzyme-linked immunosorbent assays.	7-[(3-Aminopropyl)amino]-1,1,1-Trifluoroheptane-2,2-Diol	197-200	interleukin 1 beta	Homo sapiens	100-118
8089188-9	1994	When adhering monocytes are treated with the tyrosine kinase inhibitors genistein or herbimycin, both phosphorylation of pp76 and induction of IL-1 beta message are blocked in a dose-dependent fashion.	Genistein	72-81	interleukin 1 beta	Homo sapiens	143-152
8089188-9	1994	When adhering monocytes are treated with the tyrosine kinase inhibitors genistein or herbimycin, both phosphorylation of pp76 and induction of IL-1 beta message are blocked in a dose-dependent fashion.	herbimycin	85-95	interleukin 1 beta	Homo sapiens	143-152
8089188-10	1994	Similarly, treatment with genistein or herbimycin can block tyrosine phosphorylation of pp76 and IL-1 beta message induction mediated by ligation of beta 1 integrin with antibodies.	Genistein	26-35	interleukin 1 beta	Homo sapiens	97-106
8089188-10	1994	Similarly, treatment with genistein or herbimycin can block tyrosine phosphorylation of pp76 and IL-1 beta message induction mediated by ligation of beta 1 integrin with antibodies.	herbimycin	39-49	interleukin 1 beta	Homo sapiens	97-106
8089188-10	1994	Similarly, treatment with genistein or herbimycin can block tyrosine phosphorylation of pp76 and IL-1 beta message induction mediated by ligation of beta 1 integrin with antibodies.	Tyrosine	60-68	interleukin 1 beta	Homo sapiens	97-106
7519646-2	1994	This study investigates the ability of the experimental drug suramin to block the activation of HUVEC by endotoxin and by the proinflammatory cytokines IL-1 and TNF.	Suramin	61-68	interleukin 1 beta	Homo sapiens	152-164
7519646-3	1994	We demonstrate that the inducible expression of several adhesion molecules by LPS and IL-1 beta but not by TNF-alpha is prevented by suramin.	Suramin	133-140	interleukin 1 beta	Homo sapiens	86-95
7519646-4	1994	In a dose-dependent manner, suramin inhibits the binding of neutrophils and T lymphocytes to LPS and IL-1 beta but not to TNF-alpha-activated HUVEC.	Suramin	28-35	interleukin 1 beta	Homo sapiens	101-110
8051410-6	1994	The first element is a remote kappa B binding site located far upstream between bp -2612 and -2603 that was important for IL-1 beta-, TNF-alpha-, and 2-O-tetradecanoylphorbol 13-acetate-induced enhancer activity.	Benzo(a)pyrene	80-82	interleukin 1 beta	Homo sapiens	122-131
8051418-2	1994	Inhibition of IL-1 beta production from ATP-treated monocytes and macrophages.	Adenosine Triphosphate	40-43	interleukin 1 beta	Homo sapiens	14-23
8051418-10	1994	ATP at concentrations &gt; or = 2 mM promoted IL-1 beta release from these cells.	Adenosine Triphosphate	0-3	interleukin 1 beta	Homo sapiens	46-55
8051418-13	1994	Likewise, LPS-stimulated human alveolar macrophages responded to ATP by releasing 17-kDa IL-1 beta, and tenidap inhibited this response.	Adenosine Triphosphate	65-68	interleukin 1 beta	Homo sapiens	89-98
8051418-14	1994	The ATP-induced release and maturation of IL-1 beta from human monocytes and macrophages, therefore, was suppressed by anion transport inhibitors, suggesting that anion conductance is a necessary component of the ATP-promoted externalization mechanism.	Adenosine Triphosphate	4-7	interleukin 1 beta	Homo sapiens	42-51
8051418-14	1994	The ATP-induced release and maturation of IL-1 beta from human monocytes and macrophages, therefore, was suppressed by anion transport inhibitors, suggesting that anion conductance is a necessary component of the ATP-promoted externalization mechanism.	Adenosine Triphosphate	213-216	interleukin 1 beta	Homo sapiens	42-51
7932184-0	1994	Interleukin-1 beta-mediated metallothionein induction and cytoprotection against cadmium and cis-diamminedichloroplatinum.	Cadmium	81-88	interleukin 1 beta	Homo sapiens	0-18
7932184-0	1994	Interleukin-1 beta-mediated metallothionein induction and cytoprotection against cadmium and cis-diamminedichloroplatinum.	Cisplatin	93-121	interleukin 1 beta	Homo sapiens	0-18
7932184-7	1994	DU-145 cells pretreated with IL-1 beta were 2- to 3-fold resistant to the toxicity of CdCl2 and cis-diamminedichloroplatinum(II) (cisplatin).	Cadmium Chloride	86-91	interleukin 1 beta	Homo sapiens	29-38
7932184-7	1994	DU-145 cells pretreated with IL-1 beta were 2- to 3-fold resistant to the toxicity of CdCl2 and cis-diamminedichloroplatinum(II) (cisplatin).	Cisplatin	96-124	interleukin 1 beta	Homo sapiens	29-38
7932184-7	1994	DU-145 cells pretreated with IL-1 beta were 2- to 3-fold resistant to the toxicity of CdCl2 and cis-diamminedichloroplatinum(II) (cisplatin).	Cisplatin	130-139	interleukin 1 beta	Homo sapiens	29-38
7996812-2	1994	The present study examines the regulation of prostaglandin production by human peritoneal mesothelial cells (HPMC) following stimulation with peritoneal macrophage-conditioned medium and the cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha).	Prostaglandins	45-58	interleukin 1 beta	Homo sapiens	221-230
7814457-6	1994	The selective inhibition of TNF-alpha and IL-1 beta secretion by BDPT-treated PBM was observed with all three stimuli tested.	4-O-butanoyl-4'-demethylpodophyllotoxin	65-69	interleukin 1 beta	Homo sapiens	42-51
7814457-9	1994	A comparison was made between BDPT and pentoxyfilline, a xanthine-derived phosphodisterase inhibitor that was reported to inhibit TNF-alpha and IL-1 beta secretion by PBM.	4-O-butanoyl-4'-demethylpodophyllotoxin	30-34	interleukin 1 beta	Homo sapiens	144-153
7814457-9	1994	A comparison was made between BDPT and pentoxyfilline, a xanthine-derived phosphodisterase inhibitor that was reported to inhibit TNF-alpha and IL-1 beta secretion by PBM.	Pentoxifylline	39-53	interleukin 1 beta	Homo sapiens	144-153
7814457-0	1994	Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) secretion but not IL-6 from activated human peripheral blood monocytes by a new synthetic demethylpodophyllotoxin derivative.	demethylpodophyllotoxin	179-202	interleukin 1 beta	Homo sapiens	58-76
7814457-0	1994	Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) secretion but not IL-6 from activated human peripheral blood monocytes by a new synthetic demethylpodophyllotoxin derivative.	demethylpodophyllotoxin	179-202	interleukin 1 beta	Homo sapiens	78-87
7814457-5	1994	The addition of BDPT to the stimulated cultures resulted in significant inhibition of TNF-alpha and IL-1 beta secretion, whereas the secretion of IL-6 and IL-8 was not affected.	4-O-butanoyl-4'-demethylpodophyllotoxin	16-20	interleukin 1 beta	Homo sapiens	100-109
7996812-7	1994	Co-incubation of HPMC with PMo-S.epiCM in the presence of anti-IL-1 beta and/or anti-TNF-alpha antibody, interleukin-1 receptor antagonist or soluble TNF receptor (TNF p75) significantly reduced the capacity of these supernatants to stimulate prostaglandin synthesis.	pmo-s	27-32	interleukin 1 beta	Homo sapiens	63-72
7996812-7	1994	Co-incubation of HPMC with PMo-S.epiCM in the presence of anti-IL-1 beta and/or anti-TNF-alpha antibody, interleukin-1 receptor antagonist or soluble TNF receptor (TNF p75) significantly reduced the capacity of these supernatants to stimulate prostaglandin synthesis.	Prostaglandins	243-256	interleukin 1 beta	Homo sapiens	63-72
7996812-3	1994	IL-1 beta and TNF-alpha stimulated significant release of prostaglandin above background levels in a time and dose dependent manner.	Prostaglandins	58-71	interleukin 1 beta	Homo sapiens	0-9
7996812-4	1994	Stimulation of HPMC with IL-1 beta (500 pg/ml) or TNF-alpha (100 pg/ml) for 24 hours resulted in the release of 24.5 +/- 4.3 (N = 11) (z = 3.40, P &lt; 0.001 vs. control) and 19.4 +/- 4.5 (N = 10; z = 3.29, P &lt; 0.001 vs. control) pg 6-keto-PGF1 a/micrograms cellular protein, respectively.	pg 6-keto-pgf1 a	233-249	interleukin 1 beta	Homo sapiens	25-34
8062926-4	1994	Sulfatides enhanced expression of tumor necrosis factor, interleukin-8, and interleukin-1 beta, but not interleukin-12/natural killer cell stimulating factor mRNAs.	Sulfoglycosphingolipids	0-10	interleukin 1 beta	Homo sapiens	76-94
7809384-3	1994	We present evidence in this report that liposome associated PGE1 (LAP) reduces markedly acute inflammation induced in a subcutaneous air pouch by monosodium urate crystals, and by the polypeptide mediators, interleukin 1-beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha).	Alprostadil	60-64	interleukin 1 beta	Homo sapiens	207-225
7809384-3	1994	We present evidence in this report that liposome associated PGE1 (LAP) reduces markedly acute inflammation induced in a subcutaneous air pouch by monosodium urate crystals, and by the polypeptide mediators, interleukin 1-beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha).	Alprostadil	60-64	interleukin 1 beta	Homo sapiens	227-236
8070572-1	1994	We show that sequence and growth temperature effects on IB formation in the small, monomeric beta-barrel protein interleukin-1 beta (IL-1 beta) can be quantitatively reproduced in an in vitro system in which IL-1 beta is refolded from denaturant at different temperatures.	denaturant	235-245	interleukin 1 beta	Homo sapiens	113-131
8070572-1	1994	We show that sequence and growth temperature effects on IB formation in the small, monomeric beta-barrel protein interleukin-1 beta (IL-1 beta) can be quantitatively reproduced in an in vitro system in which IL-1 beta is refolded from denaturant at different temperatures.	denaturant	235-245	interleukin 1 beta	Homo sapiens	133-142
8070572-1	1994	We show that sequence and growth temperature effects on IB formation in the small, monomeric beta-barrel protein interleukin-1 beta (IL-1 beta) can be quantitatively reproduced in an in vitro system in which IL-1 beta is refolded from denaturant at different temperatures.	denaturant	235-245	interleukin 1 beta	Homo sapiens	208-217
7519214-4	1994	TNF-alpha and IL-1 beta secretion were completely blocked by protein kinase C (PKC) and cyclic nucleotide-dependent protein kinase inhibitor, H-7, but were not affected by H-89, a specific cyclic nucleotide-dependent protein kinase inhibitor.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	142-145	interleukin 1 beta	Homo sapiens	14-23
7519214-4	1994	TNF-alpha and IL-1 beta secretion were completely blocked by protein kinase C (PKC) and cyclic nucleotide-dependent protein kinase inhibitor, H-7, but were not affected by H-89, a specific cyclic nucleotide-dependent protein kinase inhibitor.	Nucleotides, Cyclic	88-105	interleukin 1 beta	Homo sapiens	14-23
11550679-4	1994	As measured by the accumulation of NO2- in culture medium, NO production by IL-1-stimulated chondrocytes was inhibited by the NO synthase inhibitor Ng-monomethyl-L-arginine (NMA) and dependent on the presence of exogenous L-arginine.	Nitrogen Dioxide	35-38	interleukin 1 beta	Homo sapiens	76-80
11550679-4	1994	As measured by the accumulation of NO2- in culture medium, NO production by IL-1-stimulated chondrocytes was inhibited by the NO synthase inhibitor Ng-monomethyl-L-arginine (NMA) and dependent on the presence of exogenous L-arginine.	omega-N-Methylarginine	148-172	interleukin 1 beta	Homo sapiens	76-80
11550679-4	1994	As measured by the accumulation of NO2- in culture medium, NO production by IL-1-stimulated chondrocytes was inhibited by the NO synthase inhibitor Ng-monomethyl-L-arginine (NMA) and dependent on the presence of exogenous L-arginine.	omega-N-Methylarginine	174-177	interleukin 1 beta	Homo sapiens	76-80
11550679-4	1994	As measured by the accumulation of NO2- in culture medium, NO production by IL-1-stimulated chondrocytes was inhibited by the NO synthase inhibitor Ng-monomethyl-L-arginine (NMA) and dependent on the presence of exogenous L-arginine.	Arginine	162-172	interleukin 1 beta	Homo sapiens	76-80
11550679-8	1994	In beginning to define potential effects of NO on chondrocyte function, it is shown that IL-1 induced an increase in cyclic guanosine monophosphate (cGMP) which was inhibited by NMA.	Cyclic GMP	117-147	interleukin 1 beta	Homo sapiens	89-93
11550679-8	1994	In beginning to define potential effects of NO on chondrocyte function, it is shown that IL-1 induced an increase in cyclic guanosine monophosphate (cGMP) which was inhibited by NMA.	Cyclic GMP	149-153	interleukin 1 beta	Homo sapiens	89-93
11550679-8	1994	In beginning to define potential effects of NO on chondrocyte function, it is shown that IL-1 induced an increase in cyclic guanosine monophosphate (cGMP) which was inhibited by NMA.	omega-N-Methylarginine	178-181	interleukin 1 beta	Homo sapiens	89-93
8078306-3	1994	The aim of this study was to investigate the mode of action by which interleukin-1 beta (IL-1 beta) induced collagenase and stromelysin mRNA expression and synthesis in normal human synoviocytes and to explore mechanisms of suppression of these proteolytic enzymes by prostaglandins (PG).	Prostaglandins	268-282	interleukin 1 beta	Homo sapiens	69-87
8049234-6	1994	The contributions of hydrogen bonding and hydrophobic interactions to the stability of interleukin-1 beta are analyzed and compared to those for other globular proteins.	Hydrogen	21-29	interleukin 1 beta	Homo sapiens	87-105
7917990-3	1994	In comparison with controls, the addition of subtoxic NiSO4 concentrations (0.1-20 micrograms/ml) to keratinocyte cultures induced a significant, but low release of IL-1 alpha and IL-1 beta at 24 and 48 h, detectable by enzyme-linked immunosorbent assay of the supernatants of treated cells.	nickel sulfate	54-59	interleukin 1 beta	Homo sapiens	180-189
7518383-6	1994	Perfusion with 0.1 microM hIL-1 beta, but not with 1 microM hIL-1 beta, produced a decrease in 5-hydroxyindoleacetic acid levels, followed by a return to preinfusion levels.	Hydroxyindoleacetic Acid	95-121	interleukin 1 beta	Homo sapiens	26-36
7518383-7	1994	Moreover, intrahippocampal administration of hIL-1 beta increased hypothalamic-pituitary-adrenocortical axis activity, as evidenced by marked increases in both plasma ACTH and plasma and dialysate corticosterone levels.	Corticosterone	197-211	interleukin 1 beta	Homo sapiens	45-55
7518383-8	1994	In addition, a rise in body temperature by approximately 2 C was observed at time points at which the effects of hIL-1 beta on 5-HT and corticosterone levels were (near-)maximal.	Corticosterone	136-150	interleukin 1 beta	Homo sapiens	113-123
7959961-1	1994	The aim of the present work was to study the regulatory effects of cytokines (TNF alpha, IL-1 beta and IL-2) on the production of the prostglandins (PGI2 and TXA2) from human mononuclear cells.	prostglandins	134-147	interleukin 1 beta	Homo sapiens	89-98
7959961-1	1994	The aim of the present work was to study the regulatory effects of cytokines (TNF alpha, IL-1 beta and IL-2) on the production of the prostglandins (PGI2 and TXA2) from human mononuclear cells.	Epoprostenol	149-153	interleukin 1 beta	Homo sapiens	89-98
7959961-2	1994	Our major findings were: (1) TNF alpha, IL-1 beta and IL-2 were all able to induce PGI2 and TXA2 syntheses in mononuclear cells.	Epoprostenol	83-87	interleukin 1 beta	Homo sapiens	40-49
8046336-0	1994	Interleukin 1 beta propeptide is detected intracellularly and extracellularly when human monocytes are stimulated with LPS in vitro.	propeptide	19-29	interleukin 1 beta	Homo sapiens	0-18
8046336-1	1994	Human interleukin 1 beta (IL-1 beta) is synthesized as an inactive precursor that is cleaved by IL-1 converting enzyme (ICE) between Asp116 and Ala117 to form COOH-terminal mature IL-1 beta and NH2-terminal IL-1 beta propeptide.	Carbonic Acid	159-163	interleukin 1 beta	Homo sapiens	6-24
8046336-1	1994	Human interleukin 1 beta (IL-1 beta) is synthesized as an inactive precursor that is cleaved by IL-1 converting enzyme (ICE) between Asp116 and Ala117 to form COOH-terminal mature IL-1 beta and NH2-terminal IL-1 beta propeptide.	Carbonic Acid	159-163	interleukin 1 beta	Homo sapiens	26-35
8046336-1	1994	Human interleukin 1 beta (IL-1 beta) is synthesized as an inactive precursor that is cleaved by IL-1 converting enzyme (ICE) between Asp116 and Ala117 to form COOH-terminal mature IL-1 beta and NH2-terminal IL-1 beta propeptide.	Carbonic Acid	159-163	interleukin 1 beta	Homo sapiens	180-189
8046336-1	1994	Human interleukin 1 beta (IL-1 beta) is synthesized as an inactive precursor that is cleaved by IL-1 converting enzyme (ICE) between Asp116 and Ala117 to form COOH-terminal mature IL-1 beta and NH2-terminal IL-1 beta propeptide.	Carbonic Acid	159-163	interleukin 1 beta	Homo sapiens	180-189
8046336-1	1994	Human interleukin 1 beta (IL-1 beta) is synthesized as an inactive precursor that is cleaved by IL-1 converting enzyme (ICE) between Asp116 and Ala117 to form COOH-terminal mature IL-1 beta and NH2-terminal IL-1 beta propeptide.	propeptide	217-227	interleukin 1 beta	Homo sapiens	6-24
8046336-1	1994	Human interleukin 1 beta (IL-1 beta) is synthesized as an inactive precursor that is cleaved by IL-1 converting enzyme (ICE) between Asp116 and Ala117 to form COOH-terminal mature IL-1 beta and NH2-terminal IL-1 beta propeptide.	propeptide	217-227	interleukin 1 beta	Homo sapiens	26-35
8046336-3	1994	In this study, human recombinant (hr)IL-1 beta propeptide (amino acids 2-116) was produced and used to prepare specific antibodies which do not recognize mature human IL-1 beta.	propeptide	47-57	interleukin 1 beta	Homo sapiens	37-46
8046336-6	1994	The larger of these two proteins has a migration nearly identical to that of the recombinant IL-1 beta propeptide, and most likely represents naturally derived propeptide.	propeptide	103-113	interleukin 1 beta	Homo sapiens	93-102
8046336-6	1994	The larger of these two proteins has a migration nearly identical to that of the recombinant IL-1 beta propeptide, and most likely represents naturally derived propeptide.	propeptide	160-170	interleukin 1 beta	Homo sapiens	93-102
8078306-3	1994	The aim of this study was to investigate the mode of action by which interleukin-1 beta (IL-1 beta) induced collagenase and stromelysin mRNA expression and synthesis in normal human synoviocytes and to explore mechanisms of suppression of these proteolytic enzymes by prostaglandins (PG).	Prostaglandins	268-282	interleukin 1 beta	Homo sapiens	89-98
8078306-3	1994	The aim of this study was to investigate the mode of action by which interleukin-1 beta (IL-1 beta) induced collagenase and stromelysin mRNA expression and synthesis in normal human synoviocytes and to explore mechanisms of suppression of these proteolytic enzymes by prostaglandins (PG).	Prostaglandins	284-286	interleukin 1 beta	Homo sapiens	69-87
8078306-3	1994	The aim of this study was to investigate the mode of action by which interleukin-1 beta (IL-1 beta) induced collagenase and stromelysin mRNA expression and synthesis in normal human synoviocytes and to explore mechanisms of suppression of these proteolytic enzymes by prostaglandins (PG).	Prostaglandins	284-286	interleukin 1 beta	Homo sapiens	89-98
8048967-0	1994	Dexamethasone suppression of IL-1 beta-induced cyclooxygenase 2 expression is not mediated by lipocortin-1 in A549 cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	29-38
7969016-7	1994	However, with Polymethylmethacrylate (PMMA) membrane, there found production of IL-6, IL-1 alpha, IL-1 beta and TNF-alpha in extremely small quantities.	Polymethyl Methacrylate	14-36	interleukin 1 beta	Homo sapiens	98-107
7969016-7	1994	However, with Polymethylmethacrylate (PMMA) membrane, there found production of IL-6, IL-1 alpha, IL-1 beta and TNF-alpha in extremely small quantities.	Polymethyl Methacrylate	38-42	interleukin 1 beta	Homo sapiens	98-107
8048967-3	1994	Dexamethasone completely suppressed the induction of cox 2 only if present during the first 3.5h of IL-1 beta treatment but not if added after 3.5h.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	100-109
8048063-2	1994	TCDD alters the expression of a number of specific genes in the transformed human keratinocyte cell line, SCC-12F, including transforming growth factor-alpha (TGF-alpha), TGF-beta 2, plasminogen activator inhibitor-2 (PAI-2), and interleukin-1 beta (IL-1 beta).	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Homo sapiens	230-248
8048063-2	1994	TCDD alters the expression of a number of specific genes in the transformed human keratinocyte cell line, SCC-12F, including transforming growth factor-alpha (TGF-alpha), TGF-beta 2, plasminogen activator inhibitor-2 (PAI-2), and interleukin-1 beta (IL-1 beta).	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Homo sapiens	250-259
8048063-5	1994	TCDD altered both the mRNA and protein concentrations of TGF-alpha, TGF-beta 2, PAI-2, and IL-1 beta.	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Homo sapiens	91-100
8041631-0	1994	Translational enhancement of H-ferritin mRNA by interleukin-1 beta acts through 5" leader sequences distinct from the iron responsive element.	Iron	118-122	interleukin 1 beta	Homo sapiens	48-66
8053940-2	1994	On monocyte/macrophages, oleic acid strongly inhibited LPS-induced tissue factor expression, a similar activity also being obtained with regard to the pyrogenic effects of IL-1 beta.	Oleic Acid	25-35	interleukin 1 beta	Homo sapiens	172-181
8021507-2	1994	A recombinant plasmid pIL-1(-4000)-CAT, containing 4 kb of the IL-1 beta gene upstream regulatory sequence was transactivated by the p65 subunit of NF-kappa B or by treatment of the cells with a combination of NF-kappa B inducers including LPS, PMA, and dibutyryl cyclic AMP (L+P+C) in U937 cells.	Bucladesine	254-274	interleukin 1 beta	Homo sapiens	63-72
8025949-10	1994	PB-PMNs in culture also showed mRNA expression for IL-1 alpha, IL-1 beta, and TNF alpha in a time- and dose-dependent manner, especially after stimulation with zymosan.	pb-pmns	0-7	interleukin 1 beta	Homo sapiens	63-72
7976083-0	1994	Effects of cis- and trans-urocanic acids on the secretion of interleukin-1 beta and tumour necrosis factor-alpha by human peripheral blood monocytes.	cis- and trans-urocanic acids	11-40	interleukin 1 beta	Homo sapiens	61-112
7976083-2	1994	Trans-UCA augmented the interleukin-1 beta production and inhibited tumour necrosis factor-alpha production in a dose-dependent manner, whereas cis-UCA had no effect on the secretion of these cytokines by phorbol myristate acetate or lipopolysaccharide-stimulated monocytes.	Urocanic Acid	0-9	interleukin 1 beta	Homo sapiens	24-42
8018657-1	1994	An increase in dermatan sulfate-proteoglycan (DSPG) production occurs in cultured aortic smooth muscle cells exposed to macrophage-conditioned media, an effect that is abrogated by an antibody to interleukin-1 (IL-1).	Dermatan Sulfate	15-31	interleukin 1 beta	Homo sapiens	211-215
7993815-4	1994	We first showed that [3H]thymidine incorporation by L2AK cells is enhanced by IL-1 beta in a clear dose-dependent manner.	Tritium	22-24	interleukin 1 beta	Homo sapiens	78-87
7993815-5	1994	Addition of the CD10 inhibitor, phosphoramidon, together with IL-1 beta resulted in a left shift in the dose-response curve which corresponded to a 10-fold potentiation of the IL-1 beta effect.	phosphoramidon	32-46	interleukin 1 beta	Homo sapiens	176-185
7517798-3	1994	METHODS AND RESULTS: We studied the effect of human recombinant interleukin-1 beta (IL-1 beta) on synthesis of NO2-/NO3- (NOx) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes.	Nitrogen Dioxide	111-114	interleukin 1 beta	Homo sapiens	64-82
7517798-3	1994	METHODS AND RESULTS: We studied the effect of human recombinant interleukin-1 beta (IL-1 beta) on synthesis of NO2-/NO3- (NOx) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes.	Nitrogen Dioxide	111-114	interleukin 1 beta	Homo sapiens	84-93
7517798-3	1994	METHODS AND RESULTS: We studied the effect of human recombinant interleukin-1 beta (IL-1 beta) on synthesis of NO2-/NO3- (NOx) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes.	punky blue	116-119	interleukin 1 beta	Homo sapiens	64-82
7517798-3	1994	METHODS AND RESULTS: We studied the effect of human recombinant interleukin-1 beta (IL-1 beta) on synthesis of NO2-/NO3- (NOx) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes.	punky blue	116-119	interleukin 1 beta	Homo sapiens	84-93
7517798-3	1994	METHODS AND RESULTS: We studied the effect of human recombinant interleukin-1 beta (IL-1 beta) on synthesis of NO2-/NO3- (NOx) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes.	nicotine 1-N-oxide	122-125	interleukin 1 beta	Homo sapiens	64-82
7517798-3	1994	METHODS AND RESULTS: We studied the effect of human recombinant interleukin-1 beta (IL-1 beta) on synthesis of NO2-/NO3- (NOx) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes.	nicotine 1-N-oxide	122-125	interleukin 1 beta	Homo sapiens	84-93
7922784-0	1994	Dexamethasone regulates IL-1 beta and TNF-alpha-induced interleukin-8 production in human bone marrow stromal and osteoblast-like cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	24-33
7922784-6	1994	Dexamethasone (10(-7) M) significantly inhibited IL-1 beta plus TNF-alpha stimulated IL-8 production in HBMS, MG-63, and hOB cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	49-58
8025949-10	1994	PB-PMNs in culture also showed mRNA expression for IL-1 alpha, IL-1 beta, and TNF alpha in a time- and dose-dependent manner, especially after stimulation with zymosan.	Zymosan	160-167	interleukin 1 beta	Homo sapiens	63-72
7831193-4	1994	In vivo interleukin-1 beta (IL-1 beta), given orally or peripherally, produced increases (P &lt; 0.01) the serum corticosterone concentration which were reversed by pretreatment with dexamethasone.	Corticosterone	113-127	interleukin 1 beta	Homo sapiens	8-26
7841356-1	1994	In vitro monocyte-derived tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production was assessed in iron deficient with anemia (IDA), iron deficient without anemia (ID) and control infants.	Iron	129-133	interleukin 1 beta	Homo sapiens	71-89
7841356-1	1994	In vitro monocyte-derived tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production was assessed in iron deficient with anemia (IDA), iron deficient without anemia (ID) and control infants.	Iron	129-133	interleukin 1 beta	Homo sapiens	91-100
7928300-2	1994	Both MDP and romurtide stimulated the production of interleukin-1 (IL-1), IL-6, tumor necrosis factor (TNF) and IL-1 receptor antagonist (IL-1Ra).	romurtide	13-22	interleukin 1 beta	Homo sapiens	67-71
7928300-5	1994	Dose-response study indicated that romurtide was far more potent than MDP in induction of IL-1, IL-6 and TNF.	romurtide	35-44	interleukin 1 beta	Homo sapiens	90-94
8005288-2	1994	We have noted the potential for the cytokines IL-1 alpha, IL-1 beta, and TNF alpha to stimulate reactive oxygen species production by fertile donor sperm at levels that are consistent with the levels of IL-1 occurring in human seminal plasma.	Reactive Oxygen Species	96-119	interleukin 1 beta	Homo sapiens	58-67
8005288-2	1994	We have noted the potential for the cytokines IL-1 alpha, IL-1 beta, and TNF alpha to stimulate reactive oxygen species production by fertile donor sperm at levels that are consistent with the levels of IL-1 occurring in human seminal plasma.	Reactive Oxygen Species	96-119	interleukin 1 beta	Homo sapiens	46-50
8021269-2	1994	TNF-alpha and IL-1 beta are known to initiate signaling through a pathway involving hydrolysis of sphingomyelin to ceramide (Kolesnick, R. N., and Golde, D. W. (1994) Cell 77, 325-328).	Sphingomyelins	98-111	interleukin 1 beta	Homo sapiens	14-23
8021269-2	1994	TNF-alpha and IL-1 beta are known to initiate signaling through a pathway involving hydrolysis of sphingomyelin to ceramide (Kolesnick, R. N., and Golde, D. W. (1994) Cell 77, 325-328).	Ceramides	115-123	interleukin 1 beta	Homo sapiens	14-23
8207242-7	1994	IL-1 beta mRNA was released from polyribosomes by treating the cells with puromycin, suggesting that the ribosomes are not frozen at the elongation phase of protein synthesis.	Puromycin	74-83	interleukin 1 beta	Homo sapiens	0-9
7950978-2	1994	These cells also possess bradykinin B2 receptors coupled to phospholipase C and consequent increases in intracellular calcium and protein kinase C. Interleukin 1 beta causes an increase in c-fos, AP-1 transcriptional activity and an increased expression of several genes including NGF, but the initial signalling events are unknown.	Calcium	118-125	interleukin 1 beta	Homo sapiens	148-166
8090286-1	1994	Utilizing the push-pull perfusion technique, we examined the effect of an intravenous bolus injection of recombinant human interleukin (IL)-1 beta on the release of prostaglandin E2 (PGE2), CRF, and AVP in several hypothalamic areas of freely moving rats, simultaneously monitoring plasma ACTH levels.	Dinoprostone	165-181	interleukin 1 beta	Homo sapiens	123-146
8090286-1	1994	Utilizing the push-pull perfusion technique, we examined the effect of an intravenous bolus injection of recombinant human interleukin (IL)-1 beta on the release of prostaglandin E2 (PGE2), CRF, and AVP in several hypothalamic areas of freely moving rats, simultaneously monitoring plasma ACTH levels.	Dinoprostone	183-187	interleukin 1 beta	Homo sapiens	123-146
7831193-4	1994	In vivo interleukin-1 beta (IL-1 beta), given orally or peripherally, produced increases (P &lt; 0.01) the serum corticosterone concentration which were reversed by pretreatment with dexamethasone.	Corticosterone	113-127	interleukin 1 beta	Homo sapiens	28-37
7831193-4	1994	In vivo interleukin-1 beta (IL-1 beta), given orally or peripherally, produced increases (P &lt; 0.01) the serum corticosterone concentration which were reversed by pretreatment with dexamethasone.	Dexamethasone	183-196	interleukin 1 beta	Homo sapiens	8-26
7831193-4	1994	In vivo interleukin-1 beta (IL-1 beta), given orally or peripherally, produced increases (P &lt; 0.01) the serum corticosterone concentration which were reversed by pretreatment with dexamethasone.	Dexamethasone	183-196	interleukin 1 beta	Homo sapiens	28-37
7517078-0	1994	The direct effect of FK506 and rapamycin on interleukin 1(beta) and immunoglobulin production in vitro.	Tacrolimus	21-26	interleukin 1 beta	Homo sapiens	44-63
7992666-2	1994	In this paper we evaluate the presence of plasma IL-1 beta secretion in nine healthy volunteers (mean age 31.2 +/- 4.2) during post-prandial naps, after the administration of zolpidem, a benzodiazepine receptorial agonist.	Zolpidem	175-183	interleukin 1 beta	Homo sapiens	49-58
8024067-3	1994	We have examined the extent of synergy between recombinant human TNF and either recombinant human IL-1 alpha or recombinant human IL-1 beta in producing hypoglycemia and increasing plasma levels of nitric oxide in malaria (Plasmodium vinckei)-infected CBA mice.	Nitric Oxide	198-210	interleukin 1 beta	Homo sapiens	130-139
8004813-4	1994	In contrast, IL-10 was weakly expressed when fibroblasts were stimulated with LPS, IL-1 alpha or tumour necrosis factor-alpha (TNF-alpha), but the expression was enhanced in the presence of cycloheximide combined with optimal concentrations of LPS, IL-1 alpha or TNF-alpha, IL-1 alpha was a more potent stimulator than LPS for GM-CSF, IL-6, IL-8 and IL-10 expression, but not for IL-1 alpha and IL-1 beta.	Cycloheximide	190-203	interleukin 1 beta	Homo sapiens	395-404
7521256-2	1994	Interleukin-1 beta (IL-1 beta) is a potent stimulant of inducible nitric oxide synthase (iNOS) mRNA and nitric oxide (NO) production in vascular smooth muscle (VSM) cells in culture.	Nitric Oxide	66-78	interleukin 1 beta	Homo sapiens	0-18
7521256-2	1994	Interleukin-1 beta (IL-1 beta) is a potent stimulant of inducible nitric oxide synthase (iNOS) mRNA and nitric oxide (NO) production in vascular smooth muscle (VSM) cells in culture.	Nitric Oxide	66-78	interleukin 1 beta	Homo sapiens	20-29
7521256-5	1994	Dibutyryl cyclic AMP (db cyclic AMP, 0.1-1 mM), forskolin (1-10 microM) and the phosphodiesterase inhibitor, Ro 20-1724 (1-10 microM), all of which increase intracellular cyclic AMP, had no effect on NO production when added alone but markedly enhanced NO production by IL-1 beta-stimulated VSM cells in a dose-dependent manner.	Bucladesine	0-20	interleukin 1 beta	Homo sapiens	270-279
7521256-6	1994	Consistent with a cyclic AMP-mediated action, isoprenaline (1-10 microM) increased NO production from IL-1 beta-stimulated cells.	Cyclic AMP	18-28	interleukin 1 beta	Homo sapiens	102-111
7521256-6	1994	Consistent with a cyclic AMP-mediated action, isoprenaline (1-10 microM) increased NO production from IL-1 beta-stimulated cells.	Isoproterenol	46-58	interleukin 1 beta	Homo sapiens	102-111
7521256-10	1994	In addition to enhancing NO production, db cyclic AMP increased iNOS protein and mRNA above that produced by IL-1 beta alone.	db cyclic amp	40-53	interleukin 1 beta	Homo sapiens	109-118
8188340-5	1994	TNF, GM-CSF, and IL-8 strongly primed a subpopulation of PMN to produce H2O2 in response to N-formyl-methionyl-leucyl-phenylalanine (FMLP), while IL-1 alpha, IL-1 beta, and IL-6 failed to do so.	Hydrogen Peroxide	72-76	interleukin 1 beta	Homo sapiens	158-167
7952922-3	1994	Our aim was to assess the effect of IFN-gamma on the production of IL-1 by normal human keratinocytes cultured in low calcium medium (MCDB153).	calcium medium	118-132	interleukin 1 beta	Homo sapiens	67-71
7524825-6	1994	An assay which measured neutrophil rolling on interleukin (IL)-1 beta-activated human umbilical vein endothelial cells (HUVECs) showed 50% reduction in the number of rolling neutrophils in the presence of 1 microM SLeX16BSA, whereas the level of free, monovalent SLeX oligosaccharide required to produce the same effect was approximately 0.3 mM.	Oligosaccharides	268-283	interleukin 1 beta	Homo sapiens	46-69
7915999-6	1994	The sICAM-1, purified from the cell-free supernatant obtained after a 48 h culture of EC in IL-1 beta by affinity column chromatography using monoclonal ICAM-1 antibody coupled to Sepharose beads, significantly inhibited leukocyte-EC adhesion.	Sepharose	180-189	interleukin 1 beta	Homo sapiens	92-101
8188366-5	1994	Treatment of these cells (which express a very low level of HLA-DR molecules) with gamma interferon (INF-gamma) induced HLA-DR, -DQ, and -DP molecules and enabled them to respond to MAM in a dose-dependent manner, resulting in an increase in the level of steady-state mRNA for IL-1 beta and TNF-alpha.	methylazoxymethanol	182-185	interleukin 1 beta	Homo sapiens	277-286
8195695-6	1994	FACS analysis of rhodamine-phalloidin-stained MDMs showed that after incubation with IL-1 beta, but not TNF-alpha, the content of F-actin declined in MDMs, coinciding with inhibition of particle phagocytosis.	Rhodamines	17-26	interleukin 1 beta	Homo sapiens	85-94
8188366-10	1994	Finally, our results, obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting (immunoblotting), indicate that protein tyrosine kinase is involved in MAM-induced IL-1 beta and TNF-alpha gene expression in the THP-1 monocytic cell line.	methylazoxymethanol	183-186	interleukin 1 beta	Homo sapiens	195-204
8195701-7	1994	The effects of isoprenoid depletion on cytokine production were selective: IL-1 beta generation was not inhibited but the production of IL-6 and IL-8 was concomitantly suppressed.	Terpenes	15-25	interleukin 1 beta	Homo sapiens	75-84
8195695-6	1994	FACS analysis of rhodamine-phalloidin-stained MDMs showed that after incubation with IL-1 beta, but not TNF-alpha, the content of F-actin declined in MDMs, coinciding with inhibition of particle phagocytosis.	Phalloidine	27-37	interleukin 1 beta	Homo sapiens	85-94
7948430-1	1994	We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1).	Dinoprostone	173-189	interleukin 1 beta	Homo sapiens	34-38
7948430-1	1994	We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1).	Dinoprostone	173-189	interleukin 1 beta	Homo sapiens	114-118
7948430-1	1994	We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1).	Dinoprostone	191-195	interleukin 1 beta	Homo sapiens	34-38
7948430-1	1994	We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1).	Dinoprostone	191-195	interleukin 1 beta	Homo sapiens	114-118
7948430-1	1994	We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1).	Cyclic AMP	236-240	interleukin 1 beta	Homo sapiens	34-38
7948430-1	1994	We have shown that interleukin-1 (IL-1) up-regulates transcription of its own receptor and number of cell surface IL-1 receptor (IL-1R) type I molecule through induction of prostaglandin E2 (PGE2) synthesis and subsequent intracellular cAMP accumulation in a human lung fibroblast cell line (TIG-1).	Cyclic AMP	236-240	interleukin 1 beta	Homo sapiens	114-118
7948430-3	1994	In the presence of indomethacin, an inhibitor of cyclooxygenase, IL-1 inhibited the expression of IL-1R mRNA within 4 h after treatment, and the inhibition sustained at least for 24 h. IL-1 beta as well as IL-1 alpha at higher than 1 U/ml exhibited the inhibitory effect.	Indomethacin	19-31	interleukin 1 beta	Homo sapiens	65-69
7948430-3	1994	In the presence of indomethacin, an inhibitor of cyclooxygenase, IL-1 inhibited the expression of IL-1R mRNA within 4 h after treatment, and the inhibition sustained at least for 24 h. IL-1 beta as well as IL-1 alpha at higher than 1 U/ml exhibited the inhibitory effect.	Indomethacin	19-31	interleukin 1 beta	Homo sapiens	185-194
7948430-4	1994	The inhibitory effect of IL-1 was inhibited by cycloheximide suggesting that de novo protein synthesis is required.	Cycloheximide	47-60	interleukin 1 beta	Homo sapiens	25-29
8204667-0	1994	Effects of transforming growth factor beta and interleukin-1 beta on [3H]thymidine incorporation by human articular chondrocytes in vitro.	Thymidine	73-82	interleukin 1 beta	Homo sapiens	47-65
8195120-5	1994	By Northern blotting analysis, the increased expression of IL1 alpha, IL1 beta, and IL6 genes was shown to occur at 30 min of Mit C and MMS treatment and to decline after 8 h. Similarly, EMS up-regulated the expression of IL1 beta and IL6 genes.	Methyl Methanesulfonate	136-139	interleukin 1 beta	Homo sapiens	70-78
8176221-0	1994	IL-1 beta amplifies bradykinin-induced prostaglandin E2 production via a phospholipase D-linked mechanism.	Dinoprostone	39-55	interleukin 1 beta	Homo sapiens	0-9
8176221-10	1994	Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway.	Dinoprostone	65-69	interleukin 1 beta	Homo sapiens	34-38
8176221-10	1994	Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway.	Dinoprostone	65-69	interleukin 1 beta	Homo sapiens	208-219
8176221-10	1994	Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway.	Ethanol	127-134	interleukin 1 beta	Homo sapiens	34-38
8176221-10	1994	Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway.	Ethanol	127-134	interleukin 1 beta	Homo sapiens	208-219
8176221-10	1994	Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway.	Prostaglandins	223-233	interleukin 1 beta	Homo sapiens	34-38
8176221-10	1994	Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway.	Prostaglandins	223-233	interleukin 1 beta	Homo sapiens	208-219
7514870-2	1994	Previous studies have shown that pretreatment of islets for 18 h with IL-1 beta results in an inhibition of glucose-stimulated insulin secretion that requires 4 days incubation in the absence of IL-1 beta to restore islet secretory function.	Glucose	108-115	interleukin 1 beta	Homo sapiens	70-79
8179912-3	1994	We hypothesized that alveolar macrophages and bronchoalveolar lavage fluid from patients with beryllium disease and sarcoidosis would express increased levels of mRNA and proteins, respectively, for TNF-alpha, IL-1 beta, and IL-6 compared with those of normal individuals.	Beryllium	94-103	interleukin 1 beta	Homo sapiens	210-219
7910403-4	1994	When injected into inflamed rat paws (but not intravenously), IL-1 and CRF produce antinociception, which is reversible by IL-1 receptor antagonist and alpha-helical CRF, respectively, and by the immunosuppressant cyclosporine A.	Cyclosporine	214-228	interleukin 1 beta	Homo sapiens	62-66
7521152-6	1994	Although GM-CSF, IL-3 and IL-1 significantly modulated the ATRA-induced morphological changes, they did not induce CD14 expression, a typical marker of monocytic differentiation.	Tretinoin	59-63	interleukin 1 beta	Homo sapiens	26-30
7514870-4	1994	Insulin secretion is inhibited by 98% after the 18 h incubation with IL-1 beta, and this inhibition is reversed in a time-dependent fashion by NMMA, with complete recovery of insulin secretion observed 8 h after the inhibition of NO synthase.	omega-N-Methylarginine	143-147	interleukin 1 beta	Homo sapiens	69-78
7514870-5	1994	Inhibition of NO synthase also restores IL-1 beta-induced inhibition of mitochondrial aconitase activity in a time-dependent fashion that mimics the recovery of glucose-stimulated insulin secretion by islets.	Glucose	161-168	interleukin 1 beta	Homo sapiens	40-49
7514870-10	1994	The destructive effects of IL-1 beta on islet viability are prevented if NMMA is added to islet cultures during the first 24 h of exposure to IL-1 beta, but islet destruction is not prevented if NMMA is added after the first 48 h exposure to IL-1 beta.	omega-N-Methylarginine	73-77	interleukin 1 beta	Homo sapiens	27-36
8185692-2	1994	OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF.	Dinoprostone	99-115	interleukin 1 beta	Homo sapiens	126-144
8185692-2	1994	OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF.	Dinoprostone	99-115	interleukin 1 beta	Homo sapiens	146-155
7514870-10	1994	The destructive effects of IL-1 beta on islet viability are prevented if NMMA is added to islet cultures during the first 24 h of exposure to IL-1 beta, but islet destruction is not prevented if NMMA is added after the first 48 h exposure to IL-1 beta.	omega-N-Methylarginine	73-77	interleukin 1 beta	Homo sapiens	142-151
8185692-2	1994	OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF.	Dinoprostone	117-121	interleukin 1 beta	Homo sapiens	126-144
7514870-10	1994	The destructive effects of IL-1 beta on islet viability are prevented if NMMA is added to islet cultures during the first 24 h of exposure to IL-1 beta, but islet destruction is not prevented if NMMA is added after the first 48 h exposure to IL-1 beta.	omega-N-Methylarginine	73-77	interleukin 1 beta	Homo sapiens	142-151
8185692-2	1994	OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF.	Dinoprostone	117-121	interleukin 1 beta	Homo sapiens	146-155
7514870-11	1994	These results show that IL-1 beta-induced islet dysfunction is reversed by the inhibition of NO synthase, that recovery of insulin secretion is stimulated by iron and reducing agents, and that the recovery process appears to require mRNA transcription.	Iron	158-162	interleukin 1 beta	Homo sapiens	24-33
8185692-2	1994	OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF.	Dinoprostone	353-357	interleukin 1 beta	Homo sapiens	146-155
8185692-2	1994	OBJECTIVE: In order to investigate potential regulatory mechanisms for the increased production of prostaglandin E2 (PGE2) in interleukin-1 beta (IL-1 beta)-stimulated rheumatoid synovial fibroblasts (RSF), this study examined the induction of phospholipase A2 (PLA2) and prostaglandin H synthase (PGHS) enzymes and the correlation of these events with PGE2 production in IL-1 beta-stimulated RSF.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	201-204	interleukin 1 beta	Homo sapiens	146-155
7514190-6	1994	Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content.	Glucose	255-262	interleukin 1 beta	Homo sapiens	35-44
8185692-3	1994	METHODS: Protein and messenger RNA (mRNA) levels of cytosolic PLA2 (cPLA2) and PGHS-2 enzymes in IL-1 beta-stimulated RSF were measured by Western and Northern blotting, respectively, using specific antisera and complementary DNA probes.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	118-121	interleukin 1 beta	Homo sapiens	97-106
8185692-7	1994	The IL-1 receptor antagonist completely abolished the induction of these two enzymes and the stimulation of PGE2 production by IL-1 beta in RSF.	Dinoprostone	108-112	interleukin 1 beta	Homo sapiens	127-136
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	interleukin 1 beta	Homo sapiens	232-250
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	interleukin 1 beta	Homo sapiens	252-261
7514190-6	1994	Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content.	Nitrites	191-198	interleukin 1 beta	Homo sapiens	35-44
7524716-8	1994	Only the steroid budesonide appeared to reduce both spontaneous and IL-1 beta induced cytokine release.	Steroids	9-16	interleukin 1 beta	Homo sapiens	68-77
7524716-8	1994	Only the steroid budesonide appeared to reduce both spontaneous and IL-1 beta induced cytokine release.	Budesonide	17-27	interleukin 1 beta	Homo sapiens	68-77
8163567-1	1994	Addition of human, recombinant interleukin-1 beta (hrIL-1 beta) to cultures of lapine articular chondrocytes provoked a delayed increase in the production of both nitric oxide (NO) and lactate.	Nitric Oxide	163-175	interleukin 1 beta	Homo sapiens	31-49
7514193-3	1994	24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline.	Carbon-14	151-154	interleukin 1 beta	Homo sapiens	64-73
8163567-1	1994	Addition of human, recombinant interleukin-1 beta (hrIL-1 beta) to cultures of lapine articular chondrocytes provoked a delayed increase in the production of both nitric oxide (NO) and lactate.	Lactic Acid	185-192	interleukin 1 beta	Homo sapiens	31-49
8163567-9	1994	Although cells treated with IL-1 had increased rates of glycolysis, their concentrations of ATP fell below those of untreated chondrocytes in a time-dependent, but NMA-independent, manner.	Adenosine Triphosphate	92-95	interleukin 1 beta	Homo sapiens	28-32
8163567-9	1994	Although cells treated with IL-1 had increased rates of glycolysis, their concentrations of ATP fell below those of untreated chondrocytes in a time-dependent, but NMA-independent, manner.	omega-N-Methylarginine	164-167	interleukin 1 beta	Homo sapiens	28-32
7514193-3	1994	24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline.	Arginine	155-165	interleukin 1 beta	Homo sapiens	64-73
7514193-3	1994	24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline.	Carbon-14	170-173	interleukin 1 beta	Homo sapiens	64-73
7514193-3	1994	24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline.	Citrulline	174-186	interleukin 1 beta	Homo sapiens	64-73
7514193-8	1994	IFN-gamma plus TNF or IL-1 beta increased endogenous tetrahydrobiopterin levels and GTP cyclohydrolase I activity, the rate-limiting enzyme of tetrahydrobiopterin synthesis.	sapropterin	53-72	interleukin 1 beta	Homo sapiens	22-31
7514193-8	1994	IFN-gamma plus TNF or IL-1 beta increased endogenous tetrahydrobiopterin levels and GTP cyclohydrolase I activity, the rate-limiting enzyme of tetrahydrobiopterin synthesis.	sapropterin	143-162	interleukin 1 beta	Homo sapiens	22-31
9397943-12	1994	In the present study, we demonstrated that both murine TNF-alpha and human IL-1beta were potent inhibitors of hCG-induced testosterone formation.	Testosterone	122-134	interleukin 1 beta	Homo sapiens	75-83
8066992-3	1994	Likewise, approximately 1000-fold less bovine IL-1 beta than human IL-1 beta was required to prime bovine neutrophils for an enhanced luminol-dependent chemiluminescence response to opsonized zymosan particles.	Luminol	134-141	interleukin 1 beta	Homo sapiens	67-76
8041811-2	1994	We here provide evidence that UVA-induced IL-1 alpha and IL-1 beta play a central role in the induction of the synthesis both of IL-6 and collagenase/MMP-1.	uva	30-33	interleukin 1 beta	Homo sapiens	57-66
8041811-4	1994	This early peak of IL-1 bioactivity appears to be responsible for the induction of IL-6 synthesis and together with IL-6 lead to an increase of the steady-state mRNA level of collagenase/MMP-1 as deduced from studies using IL-1 alpha and IL-1 beta antisense oligonucleotides or neutralizing antibodies against IL-1 alpha and IL-1 beta.	Oligonucleotides	258-274	interleukin 1 beta	Homo sapiens	19-23
8066992-3	1994	Likewise, approximately 1000-fold less bovine IL-1 beta than human IL-1 beta was required to prime bovine neutrophils for an enhanced luminol-dependent chemiluminescence response to opsonized zymosan particles.	Zymosan	192-199	interleukin 1 beta	Homo sapiens	67-76
7512570-1	1994	In cultured vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha stimulated nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS).	Nitric Oxide	154-166	interleukin 1 beta	Homo sapiens	80-98
7513156-3	1994	Treatment of cartilage fragments with L-NG-monomethylarginine (L-NMA), a competitive inhibitor of NO synthase, both inhibited NO synthesis in response to IL-1 and CAF and restored proteoglycan synthesis.	omega-N-Methylarginine	38-61	interleukin 1 beta	Homo sapiens	154-166
7513156-3	1994	Treatment of cartilage fragments with L-NG-monomethylarginine (L-NMA), a competitive inhibitor of NO synthase, both inhibited NO synthesis in response to IL-1 and CAF and restored proteoglycan synthesis.	omega-N-Methylarginine	63-68	interleukin 1 beta	Homo sapiens	154-166
7513156-5	1994	S-nitrosylacetylpenicillamine (SNAP), an organic donor of NO, reversibly mimicked the effect of IL-1 and CAF on 35SO4(2-) incorporation.	S-Nitroso-N-Acetylpenicillamine	0-29	interleukin 1 beta	Homo sapiens	96-100
7513156-5	1994	S-nitrosylacetylpenicillamine (SNAP), an organic donor of NO, reversibly mimicked the effect of IL-1 and CAF on 35SO4(2-) incorporation.	S-Nitroso-N-Acetylpenicillamine	31-35	interleukin 1 beta	Homo sapiens	96-100
7513156-5	1994	S-nitrosylacetylpenicillamine (SNAP), an organic donor of NO, reversibly mimicked the effect of IL-1 and CAF on 35SO4(2-) incorporation.	35so4	112-117	interleukin 1 beta	Homo sapiens	96-100
7513156-1	1994	Slices of rabbit articular cartilage synthesized large quantities of nitric oxide (NO) following exposure to human recombinant interleukin-1 beta (hrIL-1 beta) or rabbit synovial cytokines (CAF).	Nitric Oxide	69-81	interleukin 1 beta	Homo sapiens	127-145
7512570-7	1994	A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol.	Nitrites	186-193	interleukin 1 beta	Homo sapiens	168-177
7512570-1	1994	In cultured vascular smooth muscle cells (VSMC), inflammatory cytokines such as interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha stimulated nitric oxide (NO) production via the expression of an inducible type of NO synthase (iNOS).	Nitric Oxide	154-166	interleukin 1 beta	Homo sapiens	100-109
7512570-7	1994	A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol.	Diglycerides	300-314	interleukin 1 beta	Homo sapiens	168-177
7512570-2	1994	A potent vasoconstrictor, angiotensin II (Ang II), which causes a rapid phospholipase C-mediated phosphoinositide hydrolysis via the Ang II type 1 (AT1) receptor in VSMC, by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose dependently inhibited the IL-1 beta-induced nitrite production.	vsmc	165-169	interleukin 1 beta	Homo sapiens	288-297
7512570-7	1994	A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol.	Phorbol Esters	30-43	interleukin 1 beta	Homo sapiens	168-177
7512570-7	1994	A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol.	Tetradecanoylphorbol Acetate	45-76	interleukin 1 beta	Homo sapiens	168-177
7512570-7	1994	A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol.	Diglycerides	103-117	interleukin 1 beta	Homo sapiens	168-177
7512570-7	1994	A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol.	1,2-dioctanoylglycerol	119-142	interleukin 1 beta	Homo sapiens	168-177
8142651-0	1994	Platelets inhibit the induction of nitric oxide synthesis by interleukin-1 beta in vascular smooth muscle cells.	Nitric Oxide	35-47	interleukin 1 beta	Homo sapiens	61-79
8042536-8	1994	Moreover, DCDF significantly enhanced IL-1 beta and IL-6 production by monocytes in a dose-dependent manner.	dcdf	10-14	interleukin 1 beta	Homo sapiens	38-47
7512424-11	1994	In view of the well known effect of IL-1 as a potent mediator of bone lysis, the results suggest a major role of the metal debris-containing macrophages in the process of osteolysis and subsequent implant loosening.	Metals	117-122	interleukin 1 beta	Homo sapiens	36-40
8142651-3	1994	Treatment of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite in the culture media and in marked elevation of intracellular cyclic guanosine monophosphate (GMP) levels.	Nitrites	97-104	interleukin 1 beta	Homo sapiens	47-56
8142651-3	1994	Treatment of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite in the culture media and in marked elevation of intracellular cyclic guanosine monophosphate (GMP) levels.	Cyclic GMP	167-197	interleukin 1 beta	Homo sapiens	47-56
8142651-3	1994	Treatment of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite in the culture media and in marked elevation of intracellular cyclic guanosine monophosphate (GMP) levels.	Guanosine Monophosphate	199-202	interleukin 1 beta	Homo sapiens	47-56
8142651-4	1994	The releasate from collagen-aggregated platelets blocked the IL-1 beta-mediated production of nitrite and the accumulation of cyclic GMP in smooth muscle cells in a platelet number-dependent manner.	Nitrites	94-101	interleukin 1 beta	Homo sapiens	61-70
8142651-4	1994	The releasate from collagen-aggregated platelets blocked the IL-1 beta-mediated production of nitrite and the accumulation of cyclic GMP in smooth muscle cells in a platelet number-dependent manner.	Cyclic GMP	126-136	interleukin 1 beta	Homo sapiens	61-70
8142651-9	1994	These results demonstrate that platelets downregulate the production of nitric oxide by IL-1 beta-treated vascular smooth muscle cells through the release of PDGF.	Nitric Oxide	72-84	interleukin 1 beta	Homo sapiens	88-97
8006515-2	1994	In the present study, the effect of the lipophilic nitrone spin trap alpha-phenyl-tert-butylnitrone (PBN) on lipoprotein oxidation and subsequent release of interleukin-1 beta was examined.	nitrones	51-58	interleukin 1 beta	Homo sapiens	157-175
7511596-0	1994	Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells.	Histamine	0-9	interleukin 1 beta	Homo sapiens	19-37
7511596-14	1994	Our results indicate that cAMP-increasing agents, such as histamine or prostaglandin E2, fail to induce IL-6 synthesis but rather enhance IL-1-induced IL-6 synthesis.	Cyclic AMP	26-30	interleukin 1 beta	Homo sapiens	138-142
7511596-14	1994	Our results indicate that cAMP-increasing agents, such as histamine or prostaglandin E2, fail to induce IL-6 synthesis but rather enhance IL-1-induced IL-6 synthesis.	Histamine	58-67	interleukin 1 beta	Homo sapiens	138-142
7511596-14	1994	Our results indicate that cAMP-increasing agents, such as histamine or prostaglandin E2, fail to induce IL-6 synthesis but rather enhance IL-1-induced IL-6 synthesis.	Dinoprostone	71-87	interleukin 1 beta	Homo sapiens	138-142
7915252-8	1994	sICAM-1, purified from cell-free supernatants obtained after a 48-h culture of EC in IL-1 beta by affinity chromatography using monoclonal ICAM-1 antibody coupled to Sepharose beads, significantly inhibited lymphocyte EC adhesion.	Sepharose	166-175	interleukin 1 beta	Homo sapiens	85-94
8006515-2	1994	In the present study, the effect of the lipophilic nitrone spin trap alpha-phenyl-tert-butylnitrone (PBN) on lipoprotein oxidation and subsequent release of interleukin-1 beta was examined.	phenyl-N-tert-butylnitrone	101-104	interleukin 1 beta	Homo sapiens	157-175
8126130-9	1994	The monocyte cytokines [IL-1 alpha (5 U/mL), IL-1 beta (5 U/mL), and TNF alpha (1000 U/mL) significantly stimulated trophoblast progesterone production (nanograms per mL): JEG-3 control, 4.1 +/- 0.5; IL-1 alpha, 7.8 +/- 0.9; IL-1 beta, 8.8 +/- 0.5; and TNF alpha 7.2 +/- 0.8 (P &lt; 0.05).	Progesterone	128-140	interleukin 1 beta	Homo sapiens	45-54
8079812-0	1994	Differential sensitivity to Arg side chain modification of IL-1 beta binding to type I and type II receptors.	Arginine	28-31	interleukin 1 beta	Homo sapiens	59-68
8079812-2	1994	The role of arginine (Arg) side chains of hr-IL-1 beta in receptor recognition was studied by the modification of Arg residues with the specific reagent 1,2-cyclohexanedione.	Arginine	12-20	interleukin 1 beta	Homo sapiens	45-54
8079812-2	1994	The role of arginine (Arg) side chains of hr-IL-1 beta in receptor recognition was studied by the modification of Arg residues with the specific reagent 1,2-cyclohexanedione.	Arginine	22-25	interleukin 1 beta	Homo sapiens	45-54
8079812-2	1994	The role of arginine (Arg) side chains of hr-IL-1 beta in receptor recognition was studied by the modification of Arg residues with the specific reagent 1,2-cyclohexanedione.	Arginine	114-117	interleukin 1 beta	Homo sapiens	45-54
8079812-2	1994	The role of arginine (Arg) side chains of hr-IL-1 beta in receptor recognition was studied by the modification of Arg residues with the specific reagent 1,2-cyclohexanedione.	1,2-cyclohexanedione	153-173	interleukin 1 beta	Homo sapiens	45-54
8079812-3	1994	It was found that chemical modification of Arg residues decreased the binding potential of IL-1 beta to type I receptor dramatically (by 230-fold) while the affinity to type II receptor was reduced only moderately (by 10-fold), with an insignificant reduction of the dissociation rate.	Arginine	43-46	interleukin 1 beta	Homo sapiens	91-100
8079812-4	1994	These studies suggest that intact Arg side chains of IL-1 beta may be necessary for high affinity binding to type I IL-1 receptor, but have less importance for the interaction of IL-1 beta with type II IL-1 receptor.	Arginine	34-37	interleukin 1 beta	Homo sapiens	53-62
8079821-0	1994	Anti-inflammatory properties of IL-1 in carrageenan-induced paw oedema.	Carrageenan	40-51	interleukin 1 beta	Homo sapiens	32-36
8079821-1	1994	To evaluate any inhibitory effect of a single dose of human recombinant interleukin-1 beta (hrIL-1 beta) on the severity of carrageenan-induced oedema in rats (a commonly used model of acute inflammation), we first injected 0.1 ml of carrageenan (0.2%, 0.5%, or 2%) to induce mild, moderate, or severe inflammation, respectively into the right rear footpad.	Carrageenan	124-135	interleukin 1 beta	Homo sapiens	72-90
8186192-7	1994	Nuclear run-on experiments showed that THP inhibited transcription of the IL-1 beta gene.	Tetrahydropapaveroline	39-42	interleukin 1 beta	Homo sapiens	74-83
8014577-2	1994	While 9-hydroxyoctadecadienoic acid (9-HODE) is a constituent of oxidized LDL and can by itself induce IL-1 beta release, its potency relative to oxidized LDL suggested that other components of modified LDL may also contribute to this phenomenon.	9-hydroxyoctadecadienoic acid	6-35	interleukin 1 beta	Homo sapiens	103-112
8182360-7	1994	IL-1 beta was found to stimulate dose-dependently (0.1-10 micrograms/kg body weight) incorporation of BrdU into pituitary intermediate cell nuclei, and positive correlation between the tested doses of IL-1 beta and BrdU-labelling index was noted (r = 0.89; P &lt; 0.01).	Bromodeoxyuridine	102-106	interleukin 1 beta	Homo sapiens	0-9
8182360-7	1994	IL-1 beta was found to stimulate dose-dependently (0.1-10 micrograms/kg body weight) incorporation of BrdU into pituitary intermediate cell nuclei, and positive correlation between the tested doses of IL-1 beta and BrdU-labelling index was noted (r = 0.89; P &lt; 0.01).	Bromodeoxyuridine	102-106	interleukin 1 beta	Homo sapiens	201-210
8182360-7	1994	IL-1 beta was found to stimulate dose-dependently (0.1-10 micrograms/kg body weight) incorporation of BrdU into pituitary intermediate cell nuclei, and positive correlation between the tested doses of IL-1 beta and BrdU-labelling index was noted (r = 0.89; P &lt; 0.01).	Bromodeoxyuridine	215-219	interleukin 1 beta	Homo sapiens	0-9
8014577-2	1994	While 9-hydroxyoctadecadienoic acid (9-HODE) is a constituent of oxidized LDL and can by itself induce IL-1 beta release, its potency relative to oxidized LDL suggested that other components of modified LDL may also contribute to this phenomenon.	9-hydroxyoctadecadienoic acid	37-43	interleukin 1 beta	Homo sapiens	103-112
8126130-15	1994	We conclude that monocyte IL-1 alpha, IL-1 beta, and TNF alpha may regulate trophoblast progesterone production through paracrine effects.	Progesterone	88-100	interleukin 1 beta	Homo sapiens	38-47
8014577-8	1994	The alkenals 2,4-decadienal and 2-octenal were tested and shown to induce IL-1 beta release while their saturated homologues had no effect.	alkenals	4-12	interleukin 1 beta	Homo sapiens	74-83
8126141-4	1994	However, prostaglandin E2 levels peaked on day 4 in EEC treated with progesterone, epidermal growth factor, and IL-1 beta (208.7 +/- 92 ng/10(7) cells), whereas no prostaglandin E2 was detectable in cells not treated with IL-1 beta, indicating that these cells responded to IL-1 beta.	Dinoprostone	9-25	interleukin 1 beta	Homo sapiens	112-121
8014577-8	1994	The alkenals 2,4-decadienal and 2-octenal were tested and shown to induce IL-1 beta release while their saturated homologues had no effect.	2,4-decadienal	13-27	interleukin 1 beta	Homo sapiens	74-83
8014577-8	1994	The alkenals 2,4-decadienal and 2-octenal were tested and shown to induce IL-1 beta release while their saturated homologues had no effect.	2-octenal	32-41	interleukin 1 beta	Homo sapiens	74-83
8014577-6	1994	An inverse correlation between HODE content and TBARS was found indicating lipid-derived aldehydes also contribute to IL-1 beta release by oxidized LDL.	hode	31-35	interleukin 1 beta	Homo sapiens	118-127
8014577-6	1994	An inverse correlation between HODE content and TBARS was found indicating lipid-derived aldehydes also contribute to IL-1 beta release by oxidized LDL.	Thiobarbituric Acid Reactive Substances	48-53	interleukin 1 beta	Homo sapiens	118-127
8014577-6	1994	An inverse correlation between HODE content and TBARS was found indicating lipid-derived aldehydes also contribute to IL-1 beta release by oxidized LDL.	Aldehydes	89-98	interleukin 1 beta	Homo sapiens	118-127
8126141-4	1994	However, prostaglandin E2 levels peaked on day 4 in EEC treated with progesterone, epidermal growth factor, and IL-1 beta (208.7 +/- 92 ng/10(7) cells), whereas no prostaglandin E2 was detectable in cells not treated with IL-1 beta, indicating that these cells responded to IL-1 beta.	Dinoprostone	9-25	interleukin 1 beta	Homo sapiens	222-231
8126141-4	1994	However, prostaglandin E2 levels peaked on day 4 in EEC treated with progesterone, epidermal growth factor, and IL-1 beta (208.7 +/- 92 ng/10(7) cells), whereas no prostaglandin E2 was detectable in cells not treated with IL-1 beta, indicating that these cells responded to IL-1 beta.	Dinoprostone	9-25	interleukin 1 beta	Homo sapiens	222-231
8012123-1	1994	Interleukin 1 beta converting enzyme (ICE) is responsible for processing an inactive 31-kDa precursor to the active, mature 17-kDa Il-1 beta with cleavage occurring between the Asp116-Ala117 amide bond.	Amides	191-196	interleukin 1 beta	Homo sapiens	131-140
8159270-0	1994	IL-1 beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in vitro, but not from the amygdala.	Acetylcholine	26-39	interleukin 1 beta	Homo sapiens	0-9
8159270-6	1994	IL-1 beta (100 U/ml) had no effect on the basal AVP release from the hypothalamus, but significantly potentiated the acetylcholine-induced AVP release, lowering the threshold from 500 to 100 nM.	Acetylcholine	117-130	interleukin 1 beta	Homo sapiens	0-9
8159270-8	1994	IL-6, like IL-1 beta, also potentiated acetylcholine-induced AVP release, but to a lesser extent.	Acetylcholine	39-52	interleukin 1 beta	Homo sapiens	11-20
8159270-11	1994	Our results suggest a hypothalamic site of action of IL-1 beta and IL-6 on the acetylcholine-induced AVP release.	Acetylcholine	79-92	interleukin 1 beta	Homo sapiens	53-62
8120407-3	1994	Stimulation with IL-1 beta or TNF-alpha massively increased chemokine production and induced the generation of PGE and low amounts of IL-1ra.	Prostaglandins E	111-114	interleukin 1 beta	Homo sapiens	17-26
8208752-0	1994	Regulation of intrauterine prostaglandin biosynthesis: interactions between protein kinase C and interleukin 1 beta.	Prostaglandins	27-40	interleukin 1 beta	Homo sapiens	97-115
8208752-2	1994	Interleukin-1 beta (IL-1 beta) can stimulate PG production by intrauterine tissues and may play a significant part in the mechanisms of preterm labor associated with intrauterine infection.	Prostaglandins	45-47	interleukin 1 beta	Homo sapiens	0-18
8208752-2	1994	Interleukin-1 beta (IL-1 beta) can stimulate PG production by intrauterine tissues and may play a significant part in the mechanisms of preterm labor associated with intrauterine infection.	Prostaglandins	45-47	interleukin 1 beta	Homo sapiens	20-29
8208752-3	1994	Hence we have evaluated the effects of staurosporine and H7 (inhibitors of protein kinase C) on IL-1 beta stimulation of amnion, chorion and decidual prostaglandin E2 (PGE2) production.	Dinoprostone	150-166	interleukin 1 beta	Homo sapiens	96-105
8208752-5	1994	However with minor exceptions both protein kinase C inhibitors enhanced the stimulatory actions of IL-1 beta on PGE2 production by all three cell types.	Dinoprostone	112-116	interleukin 1 beta	Homo sapiens	99-108
8312373-1	1994	We have investigated the effects of lipopolysaccharide (LPS) and probucol (a lipid soluble antioxidant) on the gene expression of interleukin 1 alpha and beta (IL-1 alpha and IL-1 beta), and platelet-derived growth factor A chain and B chain (PDGF-A and PDGF-B) in the human monocytic cell line U-937.	Probucol	65-73	interleukin 1 beta	Homo sapiens	175-184
7908651-1	1994	Porphyromonas gingivalis fimbriae as well as synthetic peptides that mimic the fimbrial subunit protein, which includes the amino acid sequence XLTXXLTXXNXX, induced high production of proinflammatory cytokines such as interleukin-1 beta, interleukin-6, interleukin-8, tumor necrosis factor-alpha in human peripheral blood monocyte/macrophage cultures.	Peptides	55-63	interleukin 1 beta	Homo sapiens	219-237
8307982-0	1994	G(Anh)MTetra, a natural bacterial cell wall breakdown product, induces interleukin-1 beta and interleukin-6 expression in human monocytes.	mtetra	6-12	interleukin 1 beta	Homo sapiens	71-89
8307982-5	1994	G(Anh)MTetra was found to strongly induce interleukin (IL)-1 beta and IL-6 mRNA expression after 2 h and IL-1 beta and IL-6 protein secretion after 48 h of activation.	mtetra	6-12	interleukin 1 beta	Homo sapiens	42-65
8307982-5	1994	G(Anh)MTetra was found to strongly induce interleukin (IL)-1 beta and IL-6 mRNA expression after 2 h and IL-1 beta and IL-6 protein secretion after 48 h of activation.	mtetra	6-12	interleukin 1 beta	Homo sapiens	105-114
8307982-7	1994	Experiments using inhibitors of protein kinase C, protein kinase A, and tyrosine kinase-dependent pathways revealed that G(Anh)MTetra-induced IL-1 beta and IL-6 mRNA expression involves activation of an H7-inhibitable pathway.	mtetra	127-133	interleukin 1 beta	Homo sapiens	142-151
8307982-11	1994	These results indicate that G(Anh)MTetra induces IL-1 beta and IL-6 expression in human monocytes suggesting a possible role for G(Anh)MTetra in the release of cytokines during sepsis.	disaccharide tetrapeptide	28-40	interleukin 1 beta	Homo sapiens	49-58
8299714-6	1994	Prostaglandin E2 is induced in rheumatoid synovial fibroblasts by interleukin-1 beta, not altered by transforming growth factor-alpha, and is synergistically released by the combination of the two cytokines.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	66-84
8306027-5	1994	Compared with prechallenge values, significant levels of IL-1 beta were detected in all subjects during the immediate reaction (peak, 51.0 +/- 22.4 pg/ml) and LPR (peak, 78.5 +/- 22.6 pg/ml) after antigen challenges (p &lt; 0.01) but not saline challenges.	Sodium Chloride	238-244	interleukin 1 beta	Homo sapiens	57-66
8129774-10	1994	To study the mechanism of MTX action in vitro, MTX-treated and control fibroblast-like synoviocytes were stimulated with interleukin-1 beta (IL-1 beta).	Methotrexate	26-29	interleukin 1 beta	Homo sapiens	121-139
8129774-10	1994	To study the mechanism of MTX action in vitro, MTX-treated and control fibroblast-like synoviocytes were stimulated with interleukin-1 beta (IL-1 beta).	Methotrexate	47-50	interleukin 1 beta	Homo sapiens	121-139
8129774-10	1994	To study the mechanism of MTX action in vitro, MTX-treated and control fibroblast-like synoviocytes were stimulated with interleukin-1 beta (IL-1 beta).	Methotrexate	47-50	interleukin 1 beta	Homo sapiens	141-150
8112326-3	1994	Culture of Mono Mac 6 cells for 24 h with phorbol 12-myristate 13-acetate, bacterial lipopolysaccharide and the cytokines interleukin-1 beta and tumour necrosis factor-alpha enhanced mRNA abundance, with the strongest effect (tenfold) being observed with the lipopolysaccharide.	Tetradecanoylphorbol Acetate	42-73	interleukin 1 beta	Homo sapiens	122-173
8174315-2	1994	Exposure of adherent peripheral blood PMN to cytokines known to be present in RA joints (IL-1 beta, TNF-alpha, GM-CSF) resulted in enhanced O2- production from both RA and controls.	Superoxides	140-142	interleukin 1 beta	Homo sapiens	89-98
8061933-8	1994	The half-life for IL-1 alpha and IL-1 beta was estimated using actinomycin D treatment.	Dactinomycin	63-76	interleukin 1 beta	Homo sapiens	33-42
8113959-0	1994	Liposomal muramyl tripeptide up-regulates interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 gene expression in human monocytes.	muramyl tripeptide	10-28	interleukin 1 beta	Homo sapiens	63-110
8294881-9	1994	The concentrations of IL-1 alpha and IL-1 receptor antagonist required to displace the binding of IL-1 beta to the soluble form of the decoy molecule induced by Dex from PMN were, respectively, 100 and 2 times higher compared with IL-1 beta.	Dexamethasone	161-164	interleukin 1 beta	Homo sapiens	98-107
8301137-5	1994	The enhancement of M-CSF message levels in the presence of IL-1 beta was blocked by cycloheximide, suggesting that de novo protein synthesis was required.	Cycloheximide	84-97	interleukin 1 beta	Homo sapiens	59-68
8113959-4	1994	Monocyte interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha expression were all up-regulated after a 2-h incubation with L-MTP-PE.	L-MTP-PE	156-164	interleukin 1 beta	Homo sapiens	35-44
8003851-8	1994	When added to the BM cultures concomitantly with LPS, budesonide suppressed IL-1 beta and IL-6 only partially (to 30% of the control level).	Budesonide	54-64	interleukin 1 beta	Homo sapiens	76-85
8186319-6	1994	Treatment with TPA for 48 h induced expression of IL-1 beta mRNA, an effect that was enhanced two fold by LPS.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 beta	Homo sapiens	50-59
8186320-3	1994	In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner.	Zinc	19-23	interleukin 1 beta	Homo sapiens	84-93
8186320-3	1994	In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner.	Zinc Sulfate	39-44	interleukin 1 beta	Homo sapiens	84-93
8016387-4	1994	Interleukin-1 beta (IL-1 beta), EGF, ionomycin (iono), and PMA are known to stimulate prostaglandin E2 production in human chorion and decidual cells.	Dinoprostone	86-102	interleukin 1 beta	Homo sapiens	0-18
8016387-4	1994	Interleukin-1 beta (IL-1 beta), EGF, ionomycin (iono), and PMA are known to stimulate prostaglandin E2 production in human chorion and decidual cells.	Dinoprostone	86-102	interleukin 1 beta	Homo sapiens	20-29
8309477-2	1994	Genomic sequences that mediate the induction of human IL-1 beta gene transcription by lipopolysaccharide and phorbol esters are located more than 2,700 bp upstream of the transcriptional start site (cap site).	Phorbol Esters	109-123	interleukin 1 beta	Homo sapiens	54-63
7578850-2	1994	IL-1 inhibits the function of cultured human thyroid cells too, and in this study human thyroid cell production of NO in response to the TSH-stimulated influence of IL-1 beta (10(5) U/l) and TNF-alpha (10(6) U/l), alone or in combination was measured.	Thyrotropin	137-140	interleukin 1 beta	Homo sapiens	0-4
7507317-1	1994	The present study demonstrates that human retinal pigmented epithelial cells produce nitric oxide (NO) upon co-treatment with interferon gamma (IFN gamma) and interleukin-1 beta (IL-1 beta).	Nitric Oxide	85-97	interleukin 1 beta	Homo sapiens	159-177
7507317-1	1994	The present study demonstrates that human retinal pigmented epithelial cells produce nitric oxide (NO) upon co-treatment with interferon gamma (IFN gamma) and interleukin-1 beta (IL-1 beta).	Nitric Oxide	85-97	interleukin 1 beta	Homo sapiens	179-188
7717862-0	1994	Suppression of interleukin-1 beta and tumour necrosis factor-alpha biosynthesis by cadmium in in vitro activated human peripheral blood mononuclear cells.	Cadmium	83-90	interleukin 1 beta	Homo sapiens	15-66
7717862-4	1994	Cadmium at concentrations varying from 1.0 x 10(-4) to 3.3 x 10(-6) M inhibited the phytohemagglutinin induced production of interleukin-1 beta and tumour necrosis factor-alpha, in in vitro activated human peripheral blood mononuclear cells.	Cadmium	0-7	interleukin 1 beta	Homo sapiens	125-176
7717862-6	1994	The decreased messenger RNA levels at the time points of the maximum expression of interleukin-1 beta and tumour necrosis factor-alpha indicate that cadmium suppresses their production at the transcriptional level.	Cadmium	149-156	interleukin 1 beta	Homo sapiens	83-134
8292052-1	1994	We investigated the effect of recombinant human interleukin-1 beta (IL-1 beta) on catecholamine secretion from cultured bovine adrenal medullary cells.	Catecholamines	82-95	interleukin 1 beta	Homo sapiens	48-66
8292052-1	1994	We investigated the effect of recombinant human interleukin-1 beta (IL-1 beta) on catecholamine secretion from cultured bovine adrenal medullary cells.	Catecholamines	82-95	interleukin 1 beta	Homo sapiens	68-77
8111570-2	1994	Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreased the contractile responses to acetylcholine, histamine, and KCl.	Acetylcholine	117-130	interleukin 1 beta	Homo sapiens	45-54
8111570-2	1994	Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreased the contractile responses to acetylcholine, histamine, and KCl.	Histamine	132-141	interleukin 1 beta	Homo sapiens	45-54
8111570-2	1994	Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreased the contractile responses to acetylcholine, histamine, and KCl.	Potassium Chloride	147-150	interleukin 1 beta	Homo sapiens	45-54
8111570-3	1994	The inhibitory effect of IL-1 beta on the acetylcholine (10(-3) M)-induced contraction was concentration-dependent, the maximal decrease from the baseline contraction being 52 +/- 8% (mean +/- SD, p &lt; 0.001) observed with 10 ng/ml IL-1 beta.	Acetylcholine	42-55	interleukin 1 beta	Homo sapiens	25-34
8111570-3	1994	The inhibitory effect of IL-1 beta on the acetylcholine (10(-3) M)-induced contraction was concentration-dependent, the maximal decrease from the baseline contraction being 52 +/- 8% (mean +/- SD, p &lt; 0.001) observed with 10 ng/ml IL-1 beta.	Acetylcholine	42-55	interleukin 1 beta	Homo sapiens	234-243
8111570-5	1994	The IL-1 beta-induced inhibition of the contractile responses was not affected by pretreatment of tissues with indomethacin or propranolol, but it was greatly attenuated by mechanical removal of epithelium.	Indomethacin	111-123	interleukin 1 beta	Homo sapiens	4-13
8111570-5	1994	The IL-1 beta-induced inhibition of the contractile responses was not affected by pretreatment of tissues with indomethacin or propranolol, but it was greatly attenuated by mechanical removal of epithelium.	Propranolol	127-138	interleukin 1 beta	Homo sapiens	4-13
8061161-5	1994	However, IL-1 induced significantly higher blood glucose concentrations in the prediabetic period (p &lt; 0.00005) and at diabetes onset (p &lt; 0.00005) in the DP BB rats and caused episodes of blood glucose concentrations &gt; 11 mmol/l in the prediabetic period in 11/20 DP BB rats compared to 4/27 diabetes-resistant (DR) BB rats and 4/28 Wistar Furth (WF) rats (both p &lt; 0.004), compared to DP BB).	Blood Glucose	43-56	interleukin 1 beta	Homo sapiens	9-13
8061161-5	1994	However, IL-1 induced significantly higher blood glucose concentrations in the prediabetic period (p &lt; 0.00005) and at diabetes onset (p &lt; 0.00005) in the DP BB rats and caused episodes of blood glucose concentrations &gt; 11 mmol/l in the prediabetic period in 11/20 DP BB rats compared to 4/27 diabetes-resistant (DR) BB rats and 4/28 Wistar Furth (WF) rats (both p &lt; 0.004), compared to DP BB).	dp bb	161-166	interleukin 1 beta	Homo sapiens	9-13
8061161-5	1994	However, IL-1 induced significantly higher blood glucose concentrations in the prediabetic period (p &lt; 0.00005) and at diabetes onset (p &lt; 0.00005) in the DP BB rats and caused episodes of blood glucose concentrations &gt; 11 mmol/l in the prediabetic period in 11/20 DP BB rats compared to 4/27 diabetes-resistant (DR) BB rats and 4/28 Wistar Furth (WF) rats (both p &lt; 0.004), compared to DP BB).	Blood Glucose	195-208	interleukin 1 beta	Homo sapiens	9-13
8061161-5	1994	However, IL-1 induced significantly higher blood glucose concentrations in the prediabetic period (p &lt; 0.00005) and at diabetes onset (p &lt; 0.00005) in the DP BB rats and caused episodes of blood glucose concentrations &gt; 11 mmol/l in the prediabetic period in 11/20 DP BB rats compared to 4/27 diabetes-resistant (DR) BB rats and 4/28 Wistar Furth (WF) rats (both p &lt; 0.004), compared to DP BB).	dp bb	274-279	interleukin 1 beta	Homo sapiens	9-13
8061161-5	1994	However, IL-1 induced significantly higher blood glucose concentrations in the prediabetic period (p &lt; 0.00005) and at diabetes onset (p &lt; 0.00005) in the DP BB rats and caused episodes of blood glucose concentrations &gt; 11 mmol/l in the prediabetic period in 11/20 DP BB rats compared to 4/27 diabetes-resistant (DR) BB rats and 4/28 Wistar Furth (WF) rats (both p &lt; 0.004), compared to DP BB).	boeravinone B	164-166	interleukin 1 beta	Homo sapiens	9-13
7578850-2	1994	IL-1 inhibits the function of cultured human thyroid cells too, and in this study human thyroid cell production of NO in response to the TSH-stimulated influence of IL-1 beta (10(5) U/l) and TNF-alpha (10(6) U/l), alone or in combination was measured.	Thyrotropin	137-140	interleukin 1 beta	Homo sapiens	165-174
8061161-5	1994	However, IL-1 induced significantly higher blood glucose concentrations in the prediabetic period (p &lt; 0.00005) and at diabetes onset (p &lt; 0.00005) in the DP BB rats and caused episodes of blood glucose concentrations &gt; 11 mmol/l in the prediabetic period in 11/20 DP BB rats compared to 4/27 diabetes-resistant (DR) BB rats and 4/28 Wistar Furth (WF) rats (both p &lt; 0.004), compared to DP BB).	dp bb	274-279	interleukin 1 beta	Homo sapiens	9-13
7578850-3	1994	IL-1 beta, but not TNF-alpha, induced an increase in nitrite production, which was significantly reduced by the competitive inhibitor of nitric oxide synthase L-NG-monomethyl-arginine (L-NMMA) (0.1 mmol/L and 0.5 mmol/L).	Nitrites	53-60	interleukin 1 beta	Homo sapiens	0-9
7578850-3	1994	IL-1 beta, but not TNF-alpha, induced an increase in nitrite production, which was significantly reduced by the competitive inhibitor of nitric oxide synthase L-NG-monomethyl-arginine (L-NMMA) (0.1 mmol/L and 0.5 mmol/L).	omega-N-Methylarginine	159-183	interleukin 1 beta	Homo sapiens	0-9
7578850-3	1994	IL-1 beta, but not TNF-alpha, induced an increase in nitrite production, which was significantly reduced by the competitive inhibitor of nitric oxide synthase L-NG-monomethyl-arginine (L-NMMA) (0.1 mmol/L and 0.5 mmol/L).	omega-N-Methylarginine	185-191	interleukin 1 beta	Homo sapiens	0-9
8068354-5	1994	Receptor fragment (151-162) derivatized with biotin recognized also full length recombinant IL-1 beta, and binding was inhibited to 50% in the presence of 3 microM IL-1 beta (88-99) peptide.	Biotin	45-51	interleukin 1 beta	Homo sapiens	92-101
7922597-2	1994	An intrathird cerebroventricular (I3V) infusion of recombinant human IL-1 beta (rhIL-1 beta) (1-5 ng/rat) elicited a dose-dependent increase in the electrical activity of the splenic sympathetic nerve in urethane and alpha-chloralose anesthetized rats.	Urethane	204-212	interleukin 1 beta	Homo sapiens	69-78
7922597-2	1994	An intrathird cerebroventricular (I3V) infusion of recombinant human IL-1 beta (rhIL-1 beta) (1-5 ng/rat) elicited a dose-dependent increase in the electrical activity of the splenic sympathetic nerve in urethane and alpha-chloralose anesthetized rats.	Chloralose	217-233	interleukin 1 beta	Homo sapiens	69-78
8003637-4	1994	Arginine supplementation in 29 patients with diabetes mellitus prompted a 2-fold increase of IL-1 alpha from baseline levels (P &lt; 0.001) while IL-1 beta was unaffected.	Arginine	0-8	interleukin 1 beta	Homo sapiens	146-155
8275959-6	1994	In time-course studies, the addition of 10 ng/ml IL-1 beta significantly increased IL-6 production rates; this was first seen at 8 h of culture and increased in a linear fashion up to 48 h. At 48 h of culture, IL-6 levels were 17 times higher in treated VCMC (861 +/- 179 ng/ml) compared to those in nontreated VCMC (51 +/- 14 ng/ml).	vcmc	254-258	interleukin 1 beta	Homo sapiens	49-58
8275959-6	1994	In time-course studies, the addition of 10 ng/ml IL-1 beta significantly increased IL-6 production rates; this was first seen at 8 h of culture and increased in a linear fashion up to 48 h. At 48 h of culture, IL-6 levels were 17 times higher in treated VCMC (861 +/- 179 ng/ml) compared to those in nontreated VCMC (51 +/- 14 ng/ml).	vcmc	311-315	interleukin 1 beta	Homo sapiens	49-58
8275959-7	1994	In summary, IL-1 beta stimulates VCMC IL-6 production in a specific dose- and time-dependent manner.	vcmc	33-37	interleukin 1 beta	Homo sapiens	12-21
7826661-0	1994	Dioxin-enhanced expression of interleukin-1 beta in human epidermal keratinocytes: potential role in the modulation of immune and inflammatory responses.	Dioxins	0-6	interleukin 1 beta	Homo sapiens	30-48
7826661-2	1994	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been shown to enhance the expression of the cytokine, interleukin-1 beta (IL-1 beta), in a human keratinocyte cell line.	Polychlorinated Dibenzodioxins	0-35	interleukin 1 beta	Homo sapiens	101-119
7826661-2	1994	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been shown to enhance the expression of the cytokine, interleukin-1 beta (IL-1 beta), in a human keratinocyte cell line.	Polychlorinated Dibenzodioxins	0-35	interleukin 1 beta	Homo sapiens	121-130
7826661-2	1994	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been shown to enhance the expression of the cytokine, interleukin-1 beta (IL-1 beta), in a human keratinocyte cell line.	Polychlorinated Dibenzodioxins	37-41	interleukin 1 beta	Homo sapiens	101-119
7826661-2	1994	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been shown to enhance the expression of the cytokine, interleukin-1 beta (IL-1 beta), in a human keratinocyte cell line.	Polychlorinated Dibenzodioxins	37-41	interleukin 1 beta	Homo sapiens	121-130
7826661-4	1994	Treatment of these cells with TCDD resulted in increased expression of IL-1 beta mRNA.	Polychlorinated Dibenzodioxins	30-34	interleukin 1 beta	Homo sapiens	71-80
7826661-7	1994	These results indicate that, in vitro, enhanced expression of IL-1 beta is a response of normal human epidermal keratinocytes to TCDD and furthermore, that the intensity of this response may be modulated by additional growth factors, including those present in BPE.	Polychlorinated Dibenzodioxins	129-133	interleukin 1 beta	Homo sapiens	62-71
8001869-5	1994	Interleukin-1 beta (IL-1 beta) and tumor necrosis factor-beta (TNF-beta) led to a significant increase in relative fluorescence release (RFR) of fura-2 (p &lt; 0.05 and p &lt; 0.02, respectively) while endotoxin did not show significant changes of RFR of fura-2.	Fura-2	145-151	interleukin 1 beta	Homo sapiens	0-18
8001869-5	1994	Interleukin-1 beta (IL-1 beta) and tumor necrosis factor-beta (TNF-beta) led to a significant increase in relative fluorescence release (RFR) of fura-2 (p &lt; 0.05 and p &lt; 0.02, respectively) while endotoxin did not show significant changes of RFR of fura-2.	Fura-2	145-151	interleukin 1 beta	Homo sapiens	20-29
8001869-5	1994	Interleukin-1 beta (IL-1 beta) and tumor necrosis factor-beta (TNF-beta) led to a significant increase in relative fluorescence release (RFR) of fura-2 (p &lt; 0.05 and p &lt; 0.02, respectively) while endotoxin did not show significant changes of RFR of fura-2.	Fura-2	255-261	interleukin 1 beta	Homo sapiens	0-18
8001869-5	1994	Interleukin-1 beta (IL-1 beta) and tumor necrosis factor-beta (TNF-beta) led to a significant increase in relative fluorescence release (RFR) of fura-2 (p &lt; 0.05 and p &lt; 0.02, respectively) while endotoxin did not show significant changes of RFR of fura-2.	Fura-2	255-261	interleukin 1 beta	Homo sapiens	20-29
7534178-3	1994	AII by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose-dependently inhibited IL1 beta-induced nitrite production.	Nitrites	134-141	interleukin 1 beta	Homo sapiens	117-125
7534178-5	1994	In parallel with the decrease in nitrite production, AII suppressed IL1 beta-induced increases in iNOS mRNA and protein levels, as measured by Northern blotting using an iNOS cDNA probe and by immunoblotting using an anti-iNOS antibody, respectively.	Nitrites	33-40	interleukin 1 beta	Homo sapiens	68-76
8011537-2	1994	IL-1 alpha, IL-1 beta and TNF-alpha stimulated 3H-TdR uptake in leukaemic blasts in a dose-dependent fashion.	Tritium	47-49	interleukin 1 beta	Homo sapiens	12-21
8131416-9	1994	Our data suggest a role for immunoregulatory cytokines and prostanoids such as IL-1 beta and PGE2 in these interactions.	Prostaglandins	59-70	interleukin 1 beta	Homo sapiens	79-88
8068354-5	1994	Receptor fragment (151-162) derivatized with biotin recognized also full length recombinant IL-1 beta, and binding was inhibited to 50% in the presence of 3 microM IL-1 beta (88-99) peptide.	Biotin	45-51	interleukin 1 beta	Homo sapiens	164-173
7506700-2	1994	Interferon gamma, tumor necrosis factor-alpha, and interleukin-1 beta each markedly increased mRNA and protein levels of this enzyme in parallel with the production of nitrite, a stable oxidative metabolite of nitric oxide.	Nitrites	168-175	interleukin 1 beta	Homo sapiens	51-69
8195358-4	1994	Positive significant correlations were seen between IL-1 beta and prostaglandin E2 (PGE2) (r = 0.47, P &lt; 0.001), and between IL-1 beta and prostaglandin F2 alpha (PGF2 alpha) (r = 0.22, P &lt; 0.05) in pre-ovulatory follicular fluid, but not between IL-1 beta and oestradiol, or between IL-1 beta and progesterone.	Dinoprostone	66-82	interleukin 1 beta	Homo sapiens	52-61
7506700-2	1994	Interferon gamma, tumor necrosis factor-alpha, and interleukin-1 beta each markedly increased mRNA and protein levels of this enzyme in parallel with the production of nitrite, a stable oxidative metabolite of nitric oxide.	Nitric Oxide	210-222	interleukin 1 beta	Homo sapiens	51-69
7506700-4	1994	Cycloheximide, which abolished the cytokine-induced increase in nitrite production, had no effect on the interferon-gamma-induced increase in mRNA levels but partially inhibited that induced by interleukin-1 beta and markedly inhibited that induced by tumor necrosis factor-alpha.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	194-212
8195358-0	1994	Concentration of interleukin-1 beta correlates with prostaglandin E2 and F2 alpha in human pre-ovulatory follicular fluid.	Dinoprostone	52-68	interleukin 1 beta	Homo sapiens	17-35
8195358-4	1994	Positive significant correlations were seen between IL-1 beta and prostaglandin E2 (PGE2) (r = 0.47, P &lt; 0.001), and between IL-1 beta and prostaglandin F2 alpha (PGF2 alpha) (r = 0.22, P &lt; 0.05) in pre-ovulatory follicular fluid, but not between IL-1 beta and oestradiol, or between IL-1 beta and progesterone.	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	52-61
8195358-4	1994	Positive significant correlations were seen between IL-1 beta and prostaglandin E2 (PGE2) (r = 0.47, P &lt; 0.001), and between IL-1 beta and prostaglandin F2 alpha (PGF2 alpha) (r = 0.22, P &lt; 0.05) in pre-ovulatory follicular fluid, but not between IL-1 beta and oestradiol, or between IL-1 beta and progesterone.	Dinoprost	142-158	interleukin 1 beta	Homo sapiens	128-137
8195358-4	1994	Positive significant correlations were seen between IL-1 beta and prostaglandin E2 (PGE2) (r = 0.47, P &lt; 0.001), and between IL-1 beta and prostaglandin F2 alpha (PGF2 alpha) (r = 0.22, P &lt; 0.05) in pre-ovulatory follicular fluid, but not between IL-1 beta and oestradiol, or between IL-1 beta and progesterone.	Dinoprost	142-158	interleukin 1 beta	Homo sapiens	128-137
8195358-4	1994	Positive significant correlations were seen between IL-1 beta and prostaglandin E2 (PGE2) (r = 0.47, P &lt; 0.001), and between IL-1 beta and prostaglandin F2 alpha (PGF2 alpha) (r = 0.22, P &lt; 0.05) in pre-ovulatory follicular fluid, but not between IL-1 beta and oestradiol, or between IL-1 beta and progesterone.	Dinoprost	142-158	interleukin 1 beta	Homo sapiens	128-137
8195358-5	1994	Follicular fluid IL-1 beta might contribute to prostaglandin-induced oocyte maturation and ovulation.	Prostaglandins	47-60	interleukin 1 beta	Homo sapiens	17-26
8154300-0	1994	Acridinium ester labelled cytokines: receptor binding studies with human interleukin-1 alpha, interleukin-1 beta and interferon-gamma.	9-Phenylcarboxylate-10-methylacridinium	0-16	interleukin 1 beta	Homo sapiens	94-112
9419743-1	1994	OBJECTIVE: The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua.	Prostaglandins	192-205	interleukin 1 beta	Homo sapiens	139-157
8126239-5	1994	The frequency of GCF IL-1 beta-positive subjects was elevated in ED versus ES (92% versus 23%; p &lt; 0.0004, chi 2 analysis).	Einsteinium	75-77	interleukin 1 beta	Homo sapiens	21-30
7869186-3	1994	In the blood cell cultures of the untreated and sulfasalazine treated patients with Crohn"s disease and ulcerative colitis higher levels of TNF-alpha, IL-1-alpha and IL-1-beta were found whereas IL-2 production was decreased and IFN-gamma-production was not significantly different as compared to the controls.	Sulfasalazine	48-61	interleukin 1 beta	Homo sapiens	166-175
9419743-1	1994	OBJECTIVE: The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua.	Prostaglandins	192-205	interleukin 1 beta	Homo sapiens	159-168
7760523-0	1994	Changes in plasma catecholamines during fever induced by bacterial endotoxin and interleukin-1 beta.	Catecholamines	18-32	interleukin 1 beta	Homo sapiens	81-99
7760523-7	1994	These results suggest that IL-1 acts via prostaglandins on the peripheral tissues to release catecholamines into the circulation.	Prostaglandins	41-55	interleukin 1 beta	Homo sapiens	27-31
9419743-1	1994	OBJECTIVE: The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua.	Prostaglandins	207-209	interleukin 1 beta	Homo sapiens	139-157
7760523-7	1994	These results suggest that IL-1 acts via prostaglandins on the peripheral tissues to release catecholamines into the circulation.	Catecholamines	93-107	interleukin 1 beta	Homo sapiens	27-31
9419743-1	1994	OBJECTIVE: The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua.	Prostaglandins	207-209	interleukin 1 beta	Homo sapiens	159-168
9419743-5	1994	RESULTS: The concentration-related stimulation of decidual PGE2 production by IL-1 beta and TNF alpha was completely abrogated by cycloheximide and actinomycin D treatment.	Dinoprostone	59-63	interleukin 1 beta	Homo sapiens	78-87
9419743-5	1994	RESULTS: The concentration-related stimulation of decidual PGE2 production by IL-1 beta and TNF alpha was completely abrogated by cycloheximide and actinomycin D treatment.	Cycloheximide	130-143	interleukin 1 beta	Homo sapiens	78-87
9419743-5	1994	RESULTS: The concentration-related stimulation of decidual PGE2 production by IL-1 beta and TNF alpha was completely abrogated by cycloheximide and actinomycin D treatment.	Dactinomycin	148-161	interleukin 1 beta	Homo sapiens	78-87
9419743-8	1994	CONCLUSIONS: Interleukin-1 beta and TNF alpha both act on decidual PG biosynthesis in a manner requiring new protein synthesis.	Prostaglandins	67-69	interleukin 1 beta	Homo sapiens	13-31
8255163-3	1994	In this study, we showed vesnarinone had inhibitory effects on the production of tumor necrosis factor-alpha, interferon-gamma, interleukin-1 beta and interleukin-2 by stimulated human peripheral blood mononuclear cells, human Jurkat T cell line and THP-1 monocytic cell line.	vesnarinone	25-36	interleukin 1 beta	Homo sapiens	128-146
8164509-4	1994	Undifferentiated cells displayed decreased IL-1 bioactivity in response to THC.	Dronabinol	75-78	interleukin 1 beta	Homo sapiens	43-47
8164509-5	1994	However, under conditions in which THC augmented supernatant IL-1 bioactivity from THP-1 cells, ELISA studies showed that the levels of IL-1 alpha and IL-1 beta were unchanged and decreased, respectively.	Dronabinol	35-38	interleukin 1 beta	Homo sapiens	61-65
8164509-5	1994	However, under conditions in which THC augmented supernatant IL-1 bioactivity from THP-1 cells, ELISA studies showed that the levels of IL-1 alpha and IL-1 beta were unchanged and decreased, respectively.	Dronabinol	35-38	interleukin 1 beta	Homo sapiens	151-160
8164509-7	1994	These results show that THC treatment modulates cytokine production and/or release by mouse and human macrophages and the drug effects on IL-1-like bioactivity in the supernatants of the human THP-1 cells are due to increased levels of other cytokines, such as TNF-alpha, rather than IL-1 itself.	Dronabinol	24-27	interleukin 1 beta	Homo sapiens	138-142
8164509-7	1994	These results show that THC treatment modulates cytokine production and/or release by mouse and human macrophages and the drug effects on IL-1-like bioactivity in the supernatants of the human THP-1 cells are due to increased levels of other cytokines, such as TNF-alpha, rather than IL-1 itself.	Dronabinol	24-27	interleukin 1 beta	Homo sapiens	284-288
7511198-4	1994	Preincubation with estradiol-17 beta (250 or 500 pg/ml) suppressed the induction of VCAM-1 mRNA expression by interleukin-1 beta.	Estradiol	19-36	interleukin 1 beta	Homo sapiens	110-128
18475594-9	1994	IL-1 of AM origin and PGE(2) of Fb origin secreted at high levels, may be candidates for this suppression because it was abrogated by anti IL-1beta and indomethacin.	Prostaglandins E	22-25	interleukin 1 beta	Homo sapiens	139-147
7816281-4	1994	An Il-1 beta cDNA probe was 32P-labelled by random primers and hybridized to paraffin-embedded tissue sections after de-waxing.	Phosphorus-32	28-31	interleukin 1 beta	Homo sapiens	3-12
7816281-4	1994	An Il-1 beta cDNA probe was 32P-labelled by random primers and hybridized to paraffin-embedded tissue sections after de-waxing.	Paraffin	77-85	interleukin 1 beta	Homo sapiens	3-12
8190840-6	1994	In addition, IL-1 may activate brain endothelial cells to produce IL-1, IL-6, prostaglandins, etc., and secrete these substances into the brain.	Prostaglandins	78-92	interleukin 1 beta	Homo sapiens	13-17
8164509-0	1994	delta 9-Tetrahydrocannabinol (THC) modulates IL-1 bioactivity in human monocyte/macrophage cell lines.	Dronabinol	0-28	interleukin 1 beta	Homo sapiens	45-49
8164509-0	1994	delta 9-Tetrahydrocannabinol (THC) modulates IL-1 bioactivity in human monocyte/macrophage cell lines.	Dronabinol	30-33	interleukin 1 beta	Homo sapiens	45-49
8164509-1	1994	We have previously observed that delta 9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, increased supernatant interleukin-1 (IL-1) bioactivity in cultures of mouse resident peritoneal macrophages stimulated with lipopolysaccharide (LPS).	Dronabinol	33-61	interleukin 1 beta	Homo sapiens	153-157
8164509-1	1994	We have previously observed that delta 9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, increased supernatant interleukin-1 (IL-1) bioactivity in cultures of mouse resident peritoneal macrophages stimulated with lipopolysaccharide (LPS).	Dronabinol	63-66	interleukin 1 beta	Homo sapiens	153-157
8164509-3	1994	The results showed that THC increased the levels of supernatant IL-1 bioactivity of two human monocytic cell lines, but only if the cells were differentiated with phorbol myristate acetate.	Dronabinol	24-27	interleukin 1 beta	Homo sapiens	64-68
7870341-3	1994	IL-1 beta excretion (pg/mg crea) was significantly higher in iMGN patients (375, range 162-11,000) than in DNP patients (39, range 22-59, P &lt; 0.001) or healthy controls (151, range 23-481, P &lt; 0.001).	crea	27-31	interleukin 1 beta	Homo sapiens	0-9
8280164-12	1993	In these experiments IL-1 beta increases PGE2 synthesis 8 fold in IMR90 while IL-1 beta and TGF-beta added simultaneously increases PGE2 synthesis 25 fold.	Dinoprostone	41-45	interleukin 1 beta	Homo sapiens	21-30
8016588-0	1994	Leukotrien B4-induced interleukin-1 beta in synovial cells from patients with rheumatoid arthritis.	leukotrien b4	0-13	interleukin 1 beta	Homo sapiens	22-40
8016588-1	1994	We examined the role of Leukotrien B4 (LTB4) in the production of Interleukin-1 beta (IL-1 beta) by rheumatoid synovial cells since a substantial amount of LTB4 has been detected in the synovial fluid from patients with rheumatoid arthritis.	leukotrien b4	24-37	interleukin 1 beta	Homo sapiens	66-84
8016588-1	1994	We examined the role of Leukotrien B4 (LTB4) in the production of Interleukin-1 beta (IL-1 beta) by rheumatoid synovial cells since a substantial amount of LTB4 has been detected in the synovial fluid from patients with rheumatoid arthritis.	leukotrien b4	24-37	interleukin 1 beta	Homo sapiens	86-95
7743332-0	1994	Effects of cytokines tumor necrosis factor alpha and interleukin 1 beta on endotoxin-mediated inhibition of endothelium-derived relaxing factor bioactivity and nitric oxide production in vascular endothelium.	Nitric Oxide	160-172	interleukin 1 beta	Homo sapiens	53-71
7743332-2	1994	The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production.	Nitric Oxide	192-204	interleukin 1 beta	Homo sapiens	49-67
7743332-2	1994	The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production.	Nitric Oxide	192-204	interleukin 1 beta	Homo sapiens	69-77
7743332-2	1994	The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production.	nitric	192-198	interleukin 1 beta	Homo sapiens	49-67
7743332-2	1994	The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production.	nitric	192-198	interleukin 1 beta	Homo sapiens	69-77
7743332-2	1994	The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production.	Nitric Oxide	235-247	interleukin 1 beta	Homo sapiens	49-67
7743332-2	1994	The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production.	Nitric Oxide	235-247	interleukin 1 beta	Homo sapiens	69-77
8280164-12	1993	In these experiments IL-1 beta increases PGE2 synthesis 8 fold in IMR90 while IL-1 beta and TGF-beta added simultaneously increases PGE2 synthesis 25 fold.	Dinoprostone	132-136	interleukin 1 beta	Homo sapiens	78-87
8267048-5	1993	RESULTS: 5-Hydroxyeicosatetraenoic acid production was significantly increased by interleukin-1 beta and interleukin-6 treatment in amnion, chorion, and decidual cells.	5-hydroxy-6,8,11,14-eicosatetraenoic acid	9-39	interleukin 1 beta	Homo sapiens	82-100
8258685-4	1993	It is shown that LPS induced a 12- to 16-fold increase in IL-1 beta, IL-6, and TNF-alpha mRNA levels, and this was completely or more than 80% blocked by the protein tyrosine kinase specific inhibitors herbimycin A and genistein at the concentrations of 1.7 and 37 microM, respectively.	herbimycin	202-214	interleukin 1 beta	Homo sapiens	58-67
8257696-13	1993	Indeed, cholesterol enrichment attenuated IL-1 beta-, PDGF-, and TNF alpha-induced PGI2 synthesis relative to controls and was consistent with the results of in vitro labeling experiments demonstrating that cholesterol enrichment reduced the incorporation of [35S]methionine into immunoprecipitable COX-1 and COX-2 following induction by PDGF.	Cholesterol	8-19	interleukin 1 beta	Homo sapiens	42-51
8257696-13	1993	Indeed, cholesterol enrichment attenuated IL-1 beta-, PDGF-, and TNF alpha-induced PGI2 synthesis relative to controls and was consistent with the results of in vitro labeling experiments demonstrating that cholesterol enrichment reduced the incorporation of [35S]methionine into immunoprecipitable COX-1 and COX-2 following induction by PDGF.	Epoprostenol	83-87	interleukin 1 beta	Homo sapiens	42-51
8257696-13	1993	Indeed, cholesterol enrichment attenuated IL-1 beta-, PDGF-, and TNF alpha-induced PGI2 synthesis relative to controls and was consistent with the results of in vitro labeling experiments demonstrating that cholesterol enrichment reduced the incorporation of [35S]methionine into immunoprecipitable COX-1 and COX-2 following induction by PDGF.	Cholesterol	207-218	interleukin 1 beta	Homo sapiens	42-51
8257696-13	1993	Indeed, cholesterol enrichment attenuated IL-1 beta-, PDGF-, and TNF alpha-induced PGI2 synthesis relative to controls and was consistent with the results of in vitro labeling experiments demonstrating that cholesterol enrichment reduced the incorporation of [35S]methionine into immunoprecipitable COX-1 and COX-2 following induction by PDGF.	Sulfur-35	260-263	interleukin 1 beta	Homo sapiens	42-51
8257696-13	1993	Indeed, cholesterol enrichment attenuated IL-1 beta-, PDGF-, and TNF alpha-induced PGI2 synthesis relative to controls and was consistent with the results of in vitro labeling experiments demonstrating that cholesterol enrichment reduced the incorporation of [35S]methionine into immunoprecipitable COX-1 and COX-2 following induction by PDGF.	Methionine	264-274	interleukin 1 beta	Homo sapiens	42-51
8244994-3	1993	In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6.	oh radical	56-66	interleukin 1 beta	Homo sapiens	232-250
8244994-3	1993	In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6.	oh radical	56-66	interleukin 1 beta	Homo sapiens	252-256
8244994-3	1993	In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6.	Dimethyl Sulfoxide	77-95	interleukin 1 beta	Homo sapiens	232-250
8244994-3	1993	In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6.	Dimethyl Sulfoxide	77-95	interleukin 1 beta	Homo sapiens	252-256
8244994-3	1993	In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6.	me2so	97-102	interleukin 1 beta	Homo sapiens	232-250
8244994-3	1993	In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6.	me2so	97-102	interleukin 1 beta	Homo sapiens	252-256
8252313-5	1993	The results suggest that the numerous beneficial effects of PUFAs in inflammatory diseases such as RA may be due to a reduction in the secretion of the inflammatory cytokines IL-1 beta and TNF-alpha via redirection of eicosanoid metabolism although the possibility cannot be excluded that the PUFAs may be altering cytokine release directly through an effect on monocyte membranes.	Eicosanoids	218-228	interleukin 1 beta	Homo sapiens	175-184
8257595-8	1993	We found that the exposure of ASM cells to human recombinant IL-1 beta significantly (P &lt; 0.01) increased the number of tracheal myocytes as well as the [3H]-thymidine incorporation into ASM cells.	Tritium	157-159	interleukin 1 beta	Homo sapiens	61-70
8257595-8	1993	We found that the exposure of ASM cells to human recombinant IL-1 beta significantly (P &lt; 0.01) increased the number of tracheal myocytes as well as the [3H]-thymidine incorporation into ASM cells.	Thymidine	161-170	interleukin 1 beta	Homo sapiens	61-70
8257595-11	1993	The presence of indomethacin in the culture medium was essential to demonstrate the proliferative effect of IL-1 beta.	Indomethacin	16-28	interleukin 1 beta	Homo sapiens	108-117
8187790-5	1993	Interleukin 1 beta (at 4, 8 and 24 h) and tumor necrosis factor alpha (at 8 and 24 h) levels were also significantly decreased by teicoplanin.	Teicoplanin	130-141	interleukin 1 beta	Homo sapiens	0-18
7504044-6	1993	Further analysis demonstrated that ethanol inhibits the production of interleukin-1 beta (IL-1 beta) and induces transforming growth factor beta (TGF-beta) and prostaglandin E2 (PGE2), monocyte-derived mediators that can affect T cell proliferation.	Ethanol	35-42	interleukin 1 beta	Homo sapiens	70-88
8245502-6	1993	Significant reductions in both cytokine transcripts and in IL-1 beta immunoreactive protein were noted in the high expression subgroup after 1 week of cyclosporin A therapy, prior to detectable clinical improvement.	Cyclosporine	151-164	interleukin 1 beta	Homo sapiens	59-68
7504044-6	1993	Further analysis demonstrated that ethanol inhibits the production of interleukin-1 beta (IL-1 beta) and induces transforming growth factor beta (TGF-beta) and prostaglandin E2 (PGE2), monocyte-derived mediators that can affect T cell proliferation.	Ethanol	35-42	interleukin 1 beta	Homo sapiens	90-99
7504044-7	1993	Ethanol resulted in a dose-dependent down-regulation of secreted and cell-associated IL-1 beta protein as well as IL-1 beta mRNA levels induced by adherence or bacterial stimulation.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	85-94
7504044-7	1993	Ethanol resulted in a dose-dependent down-regulation of secreted and cell-associated IL-1 beta protein as well as IL-1 beta mRNA levels induced by adherence or bacterial stimulation.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	114-123
7504044-8	1993	The causal relationship between decreased m phi IL-1 beta production, elevated TGF-beta levels, and the decreased m phi APC capacity was further substantiated when exogenous IL-1 beta protein or anti-TGF-beta neutralizing antibody prevented the down-regulatory effect of ethanol on antigen-specific T cell proliferation.	Ethanol	271-278	interleukin 1 beta	Homo sapiens	48-57
7504044-8	1993	The causal relationship between decreased m phi IL-1 beta production, elevated TGF-beta levels, and the decreased m phi APC capacity was further substantiated when exogenous IL-1 beta protein or anti-TGF-beta neutralizing antibody prevented the down-regulatory effect of ethanol on antigen-specific T cell proliferation.	Ethanol	271-278	interleukin 1 beta	Homo sapiens	174-183
7504305-1	1993	Incubation of human articular chondrocytes with interleukin 1 beta results in the time-dependent expression of nitric oxide (NO) synthase.	Nitric Oxide	111-123	interleukin 1 beta	Homo sapiens	48-66
8295979-2	1993	We considered that it might block interleukin-1 beta-stimulated prostaglandin production from human decidual cells.	Prostaglandins	64-77	interleukin 1 beta	Homo sapiens	34-52
8140124-6	1993	Moreover, IL-2 also attenuated, in a concentration-related fashion, the stimulatory actions of IL-1 beta on PGE2 production by amnion cells.	Dinoprostone	108-112	interleukin 1 beta	Homo sapiens	95-104
8140125-0	1993	Interleukin-1 beta stimulates prostaglandin E2 and F2 alpha synthesis in human ovarian granulosa cells in culture.	Dinoprostone	30-46	interleukin 1 beta	Homo sapiens	0-18
8295979-3	1993	Very high levels of interleukin-1 receptor antagonist (&gt; 1000 pg/ml) had limited inhibitory effects on IL-1 beta-stimulated PGE2 synthesis, and lower levels of antagonist (&lt; 1000 pg/ml) increased the effects of IL-1 beta.	Dinoprostone	127-131	interleukin 1 beta	Homo sapiens	106-115
8140125-3	1993	IL-1 beta increased immunoreactive concentrations of PGE2 and PGF2 alpha in culture medium in time- and dose-dependent manners.	Dinoprostone	53-57	interleukin 1 beta	Homo sapiens	0-9
8256116-0	1993	Okadaic acid, a phosphatase inhibitor, enhances the phorbol ester-induced interleukin-1 beta expression via an AP-1-mediated mechanism.	Okadaic Acid	0-12	interleukin 1 beta	Homo sapiens	74-92
8140125-3	1993	IL-1 beta increased immunoreactive concentrations of PGE2 and PGF2 alpha in culture medium in time- and dose-dependent manners.	Dinoprost	62-72	interleukin 1 beta	Homo sapiens	0-9
8256116-0	1993	Okadaic acid, a phosphatase inhibitor, enhances the phorbol ester-induced interleukin-1 beta expression via an AP-1-mediated mechanism.	Phorbol Esters	52-65	interleukin 1 beta	Homo sapiens	74-92
8109849-0	1993	Hydrogen peroxide primes promonocytic U937 cells to produce IL-1 beta.	Hydrogen Peroxide	0-17	interleukin 1 beta	Homo sapiens	60-69
8256116-8	1993	Similar data were obtained with cells transfected with a reporter plasmid containing the PMA-responsive element (containing a putative AP-1 binding site) of the IL-1 beta gene.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 beta	Homo sapiens	161-170
8140125-4	1993	Concentration of PGE2 was significantly higher after 24 h incubation with 5 or more units/ml of IL-1 beta, when compared to the control value obtained without IL-1 beta (P &lt; 0.05).	Dinoprostone	17-21	interleukin 1 beta	Homo sapiens	96-105
8140125-4	1993	Concentration of PGE2 was significantly higher after 24 h incubation with 5 or more units/ml of IL-1 beta, when compared to the control value obtained without IL-1 beta (P &lt; 0.05).	Dinoprostone	17-21	interleukin 1 beta	Homo sapiens	159-168
8140125-5	1993	Concentration of PGF2 alpha was significantly higher after 8 h incubation with more than 2 units/ml of IL-1 beta (P &lt; 0.05).	Dinoprost	17-21	interleukin 1 beta	Homo sapiens	103-112
8140125-7	1993	During a 10 day incubation period, stimulatory effects of IL-1 beta on PG synthesis were observed only on the first 2 days incubations.	Prostaglandins	71-73	interleukin 1 beta	Homo sapiens	58-67
8140125-9	1993	This study demonstrated that IL-1 beta stimulates PG synthesis in human ovarian granulosa cells in vitro.	Prostaglandins	50-52	interleukin 1 beta	Homo sapiens	29-38
8250840-4	1993	IL-1 beta, TNF alpha and IFN gamma all decreased transferrin-iron uptake into cells, and all three cytokines had effects on the proportion of iron associated with ferritin.	Iron	61-65	interleukin 1 beta	Homo sapiens	0-9
8228247-7	1993	Ongoing protein synthesis was not required for IL-1 beta secretion because mature IL-1 beta release occurred in the presence of the protein synthesis inhibitor cycloheximide.	Cycloheximide	160-173	interleukin 1 beta	Homo sapiens	82-91
8228247-9	1993	We find that dexamethasone or IL-10, when added together with 100 ng/ml LPS, inhibits IL-1 beta production with IC50 levels of 0.2 microM and 2.0 ng/ml, respectively.	Dexamethasone	13-26	interleukin 1 beta	Homo sapiens	86-95
8250840-1	1993	We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937.	Iron	180-184	interleukin 1 beta	Homo sapiens	67-85
8250840-1	1993	We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937.	Iron	180-184	interleukin 1 beta	Homo sapiens	87-96
8118432-5	1993	Examination of the sizes of [35SO4]PGs on Sepharose CL-6 beta columns with and without treatment of IL-1 beta shows that the size of non-extractable [35SO4]PG decreases after IL-1 beta treatment.	35so4	150-155	interleukin 1 beta	Homo sapiens	100-109
7506668-0	1993	Cyclosporin derivatives inhibit interleukin 1 beta induction of nitric oxide synthase in renal mesangial cells.	Cyclosporine	0-11	interleukin 1 beta	Homo sapiens	32-50
7506668-1	1993	Treatment of mesangial cells with recombinant human interleukin 1 beta dose dependently increased nitrite formation due to the induction of a macrophage-type of nitric oxide (NO) synthase.	Nitrites	98-105	interleukin 1 beta	Homo sapiens	52-70
7506668-2	1993	Addition of cyclosporin A, cyclosporin G or cyclosporin H dose dependently inhibited interleukin 1 beta-induced nitrite generation.	Cyclosporine	12-25	interleukin 1 beta	Homo sapiens	85-103
7506668-2	1993	Addition of cyclosporin A, cyclosporin G or cyclosporin H dose dependently inhibited interleukin 1 beta-induced nitrite generation.	cyclosporin G	27-40	interleukin 1 beta	Homo sapiens	85-103
7506668-2	1993	Addition of cyclosporin A, cyclosporin G or cyclosporin H dose dependently inhibited interleukin 1 beta-induced nitrite generation.	cyclosporin H	44-57	interleukin 1 beta	Homo sapiens	85-103
7506668-2	1993	Addition of cyclosporin A, cyclosporin G or cyclosporin H dose dependently inhibited interleukin 1 beta-induced nitrite generation.	Nitrites	112-119	interleukin 1 beta	Homo sapiens	85-103
7506668-4	1993	Time-course studies indicated that cyclosporin A could be added up to 6 h after the interleukin 1 beta stimulus and still caused maximal inhibition of nitrite production.	Cyclosporine	35-48	interleukin 1 beta	Homo sapiens	84-102
7506668-5	1993	Furthermore, interleukin 1 beta increased NO synthase mRNA levels in mesangial cells and this effect was potently suppressed by all three cyclosporin derivatives.	Cyclosporine	138-149	interleukin 1 beta	Homo sapiens	13-31
8218354-7	1993	An increase in the release of anti-IL-1 beta-antiserum-precipitable radioactivity from U937 cells prelabelled with [35S]methionine then incubated with fatty acids in the presence of LPS further confirmed that IL-1 release was increased.	Sulfur-35	116-119	interleukin 1 beta	Homo sapiens	35-44
8218354-7	1993	An increase in the release of anti-IL-1 beta-antiserum-precipitable radioactivity from U937 cells prelabelled with [35S]methionine then incubated with fatty acids in the presence of LPS further confirmed that IL-1 release was increased.	Methionine	120-130	interleukin 1 beta	Homo sapiens	35-44
8218354-7	1993	An increase in the release of anti-IL-1 beta-antiserum-precipitable radioactivity from U937 cells prelabelled with [35S]methionine then incubated with fatty acids in the presence of LPS further confirmed that IL-1 release was increased.	Fatty Acids	151-162	interleukin 1 beta	Homo sapiens	35-44
8118432-5	1993	Examination of the sizes of [35SO4]PGs on Sepharose CL-6 beta columns with and without treatment of IL-1 beta shows that the size of non-extractable [35SO4]PG decreases after IL-1 beta treatment.	35so4	150-155	interleukin 1 beta	Homo sapiens	175-184
8118432-6	1993	Cellulose acetate plate electrophoresis of these [35SO4]PG fractions shows that the distribution of PGs alters after treatment with IL-1 beta.	acetylcellulose	0-17	interleukin 1 beta	Homo sapiens	132-141
8118432-6	1993	Cellulose acetate plate electrophoresis of these [35SO4]PG fractions shows that the distribution of PGs alters after treatment with IL-1 beta.	35so4	50-55	interleukin 1 beta	Homo sapiens	132-141
8118432-6	1993	Cellulose acetate plate electrophoresis of these [35SO4]PG fractions shows that the distribution of PGs alters after treatment with IL-1 beta.	Phosphatidylglycerols	100-103	interleukin 1 beta	Homo sapiens	132-141
8118432-7	1993	These results indicate that burn wound healing abnormalities (scarring) is related to a change in the level of PGs, and may be modified by IL-1 beta treatment.	Phosphatidylglycerols	111-114	interleukin 1 beta	Homo sapiens	139-148
8287645-2	1993	We have observed previously that extracellular ATP acting at P2-purinoceptors promotes the production of prostaglandin E2 by human articular chondrocytes, and that this response is enhanced synergistically by interleukin-1 beta.	Adenosine Triphosphate	47-50	interleukin 1 beta	Homo sapiens	209-227
7507437-1	1993	This brief overview discusses the ability of mediators associated with vascular injury, such as interleukin-1 beta and tumour necrosis factor alpha, to activate vascular smooth muscle cells to produce nitric oxide or a related donor of nitric oxide.	Nitric Oxide	201-213	interleukin 1 beta	Homo sapiens	96-147
7507437-1	1993	This brief overview discusses the ability of mediators associated with vascular injury, such as interleukin-1 beta and tumour necrosis factor alpha, to activate vascular smooth muscle cells to produce nitric oxide or a related donor of nitric oxide.	Nitric Oxide	236-248	interleukin 1 beta	Homo sapiens	96-147
7507098-2	1993	In the present study we compared PGE2 with prostacyclin (PGI2) analogs in their potency to influence LPS-stimulated production of interleukin-1 beta (IL-1 beta) and TNF-alpha by human mononuclear cells (MNC).	Epoprostenol	57-61	interleukin 1 beta	Homo sapiens	150-159
8228619-0	1993	Silica induces apoptosis in macrophages and the release of interleukin-1 alpha and interleukin-1 beta.	Silicon Dioxide	0-6	interleukin 1 beta	Homo sapiens	83-101
7507098-2	1993	In the present study we compared PGE2 with prostacyclin (PGI2) analogs in their potency to influence LPS-stimulated production of interleukin-1 beta (IL-1 beta) and TNF-alpha by human mononuclear cells (MNC).	Dinoprostone	33-37	interleukin 1 beta	Homo sapiens	130-148
7507098-2	1993	In the present study we compared PGE2 with prostacyclin (PGI2) analogs in their potency to influence LPS-stimulated production of interleukin-1 beta (IL-1 beta) and TNF-alpha by human mononuclear cells (MNC).	Dinoprostone	33-37	interleukin 1 beta	Homo sapiens	150-159
7507098-2	1993	In the present study we compared PGE2 with prostacyclin (PGI2) analogs in their potency to influence LPS-stimulated production of interleukin-1 beta (IL-1 beta) and TNF-alpha by human mononuclear cells (MNC).	Epoprostenol	43-55	interleukin 1 beta	Homo sapiens	130-148
7507098-2	1993	In the present study we compared PGE2 with prostacyclin (PGI2) analogs in their potency to influence LPS-stimulated production of interleukin-1 beta (IL-1 beta) and TNF-alpha by human mononuclear cells (MNC).	Epoprostenol	43-55	interleukin 1 beta	Homo sapiens	150-159
7507098-2	1993	In the present study we compared PGE2 with prostacyclin (PGI2) analogs in their potency to influence LPS-stimulated production of interleukin-1 beta (IL-1 beta) and TNF-alpha by human mononuclear cells (MNC).	Epoprostenol	57-61	interleukin 1 beta	Homo sapiens	130-148
8228619-2	1993	The use of anti-IL-1 antisera showed that both IL-1 alpha and IL-1 beta were present in supernatants of silica-treated macrophages.	Silicon Dioxide	104-110	interleukin 1 beta	Homo sapiens	62-71
8228619-6	1993	In agreement with previous findings showing that IL-1 beta was released only by apoptotic cells, we have found that silica-treated macrophages underwent apoptosis.	Silicon Dioxide	116-122	interleukin 1 beta	Homo sapiens	49-58
8228619-9	1993	Treatment of macrophages with silica, therefore, results in an active process that promotes the processing and liberation of IL-1 beta.	Silicon Dioxide	30-36	interleukin 1 beta	Homo sapiens	125-134
8247820-5	1993	Furthermore, incubation of human mononuclear leukocytes (MNL) in the presence of meperidine significantly reduced endotoxin-induced secretion of IL-1 beta in vitro.	Meperidine	81-91	interleukin 1 beta	Homo sapiens	145-154
8277334-0	1993	Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A.	21-aminosteroid	97-112	interleukin 1 beta	Homo sapiens	62-80
8413264-2	1993	Treatment of the transfected cells with various combinations of the inducers lipopolysaccharide, phorbol myristate acetate, and dibutyryl cyclic AMP upregulated the IL-1 beta promoter.	Tetradecanoylphorbol Acetate	97-122	interleukin 1 beta	Homo sapiens	165-174
8413264-2	1993	Treatment of the transfected cells with various combinations of the inducers lipopolysaccharide, phorbol myristate acetate, and dibutyryl cyclic AMP upregulated the IL-1 beta promoter.	Bucladesine	128-148	interleukin 1 beta	Homo sapiens	165-174
8413264-3	1993	In U937 and THP-1 cells, maximum stimulation of both the endogenous IL-1 beta gene and pIL1(4.0kb)-CAT transfectants was observed following treatment with the combination of inducing agents lipopolysaccharide-phorbol myristate acetate-dibutyryl cyclic AMP.	lipopolysaccharide-phorbol myristate acetate	190-234	interleukin 1 beta	Homo sapiens	68-77
8413264-3	1993	In U937 and THP-1 cells, maximum stimulation of both the endogenous IL-1 beta gene and pIL1(4.0kb)-CAT transfectants was observed following treatment with the combination of inducing agents lipopolysaccharide-phorbol myristate acetate-dibutyryl cyclic AMP.	dibutyryl	235-244	interleukin 1 beta	Homo sapiens	68-77
8413264-3	1993	In U937 and THP-1 cells, maximum stimulation of both the endogenous IL-1 beta gene and pIL1(4.0kb)-CAT transfectants was observed following treatment with the combination of inducing agents lipopolysaccharide-phorbol myristate acetate-dibutyryl cyclic AMP.	Cyclic AMP	245-255	interleukin 1 beta	Homo sapiens	68-77
8302918-0	1993	Prostaglandin E2 antagonizes gingival fibroblast proliferation stimulated by interleukin-1 beta.	Dinoprostone	0-16	interleukin 1 beta	Homo sapiens	77-95
8302918-1	1993	Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis.	pg	63-65	interleukin 1 beta	Homo sapiens	260-269
8153084-0	1993	Mechanism of interleukin-1 beta stimulation of human amnion prostaglandin biosynthesis: mediation via a novel inducible cyclooxygenase.	Prostaglandins	60-73	interleukin 1 beta	Homo sapiens	13-31
8153084-1	1993	We have evaluated the mechanism by which interleukin-1 beta (IL-1 beta) increases amnion cell PGE2 production in a concentration-dependent manner.	Dinoprostone	94-98	interleukin 1 beta	Homo sapiens	41-59
8153084-1	1993	We have evaluated the mechanism by which interleukin-1 beta (IL-1 beta) increases amnion cell PGE2 production in a concentration-dependent manner.	Dinoprostone	94-98	interleukin 1 beta	Homo sapiens	61-70
8153084-2	1993	IL-1 beta-stimulated amnion cell PGE2 biosynthesis was time-dependent, and significant stimulation occurred within 2 h of incubation.	Dinoprostone	33-37	interleukin 1 beta	Homo sapiens	0-9
8302918-2	1993	Addition of PGE2 to culture media containing IL-1 beta and INDO caused a significant concentration-dependent reduction in IL-1 beta- and INDO-induced stimulation of DNA synthesis.	Dinoprostone	12-16	interleukin 1 beta	Homo sapiens	45-54
8302918-1	1993	Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis.	Dinoprostone	45-61	interleukin 1 beta	Homo sapiens	226-244
8302918-2	1993	Addition of PGE2 to culture media containing IL-1 beta and INDO caused a significant concentration-dependent reduction in IL-1 beta- and INDO-induced stimulation of DNA synthesis.	Dinoprostone	12-16	interleukin 1 beta	Homo sapiens	122-131
8153084-3	1993	IL-1 beta stimulation occurred in the presence of added arachidonic acid but was abrogated by treatment with cycloheximide and actinomycin D.	Arachidonic Acid	56-72	interleukin 1 beta	Homo sapiens	0-9
8153084-3	1993	IL-1 beta stimulation occurred in the presence of added arachidonic acid but was abrogated by treatment with cycloheximide and actinomycin D.	Cycloheximide	109-122	interleukin 1 beta	Homo sapiens	0-9
8302918-2	1993	Addition of PGE2 to culture media containing IL-1 beta and INDO caused a significant concentration-dependent reduction in IL-1 beta- and INDO-induced stimulation of DNA synthesis.	Indomethacin	59-63	interleukin 1 beta	Homo sapiens	122-131
8302918-1	1993	Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis.	Dinoprostone	45-61	interleukin 1 beta	Homo sapiens	246-255
8153084-3	1993	IL-1 beta stimulation occurred in the presence of added arachidonic acid but was abrogated by treatment with cycloheximide and actinomycin D.	Dactinomycin	127-140	interleukin 1 beta	Homo sapiens	0-9
8153084-4	1993	Amnion cells treated with IL-1 beta recovered rapidly from aspirin pretreatment suggesting an action on fatty acid cyclooxygenase (COX).	Aspirin	59-66	interleukin 1 beta	Homo sapiens	26-35
8302918-1	1993	Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis.	Dinoprostone	45-61	interleukin 1 beta	Homo sapiens	260-269
8302918-1	1993	Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis.	Dinoprostone	63-67	interleukin 1 beta	Homo sapiens	226-244
8302918-1	1993	Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis.	Dinoprostone	63-67	interleukin 1 beta	Homo sapiens	246-255
8302918-1	1993	Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis.	Dinoprostone	63-67	interleukin 1 beta	Homo sapiens	260-269
8302918-1	1993	Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis.	pg	63-65	interleukin 1 beta	Homo sapiens	226-244
8302918-1	1993	Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1 beta (IL-1 beta) or IL-1 beta+INDO caused a significant and dose-dependent increase in DNA synthesis.	pg	63-65	interleukin 1 beta	Homo sapiens	246-255
8275059-0	1993	Peptidoglycan and teichoic acid from Staphylococcus epidermidis stimulate human monocytes to release tumour necrosis factor-alpha, interleukin-1 beta and interleukin-6.	Teichoic Acids	18-31	interleukin 1 beta	Homo sapiens	131-149
8238464-0	1993	An IL-1 receptor and an IL-1 receptor antagonist attenuate muramyl dipeptide- and IL-1-induced sleep and fever.	Dipeptides	67-76	interleukin 1 beta	Homo sapiens	3-7
8238464-0	1993	An IL-1 receptor and an IL-1 receptor antagonist attenuate muramyl dipeptide- and IL-1-induced sleep and fever.	Dipeptides	67-76	interleukin 1 beta	Homo sapiens	24-28
8238464-1	1993	It is hypothesized that the somnogenic and pyrogenic effects of muramyl dipeptide (MDP) are mediated via enhanced interleukin-1 (IL-1) production.	Acetylmuramyl-Alanyl-Isoglutamine	64-81	interleukin 1 beta	Homo sapiens	129-133
8238464-1	1993	It is hypothesized that the somnogenic and pyrogenic effects of muramyl dipeptide (MDP) are mediated via enhanced interleukin-1 (IL-1) production.	Acetylmuramyl-Alanyl-Isoglutamine	83-86	interleukin 1 beta	Homo sapiens	129-133
8403509-3	1993	Given that fever is often a prominent feature of hypersensitivity, we also assessed whether SMX or SMX-HA could induce the in vitro production of IL-1 beta, IL-6 or tumour necrosis factor-alpha (TNF-alpha) by PBMC.	sulfamethoxazole hydroxylamine	99-105	interleukin 1 beta	Homo sapiens	146-155
8403509-11	1993	Exposure of PBMC to SMX-HA resulted in a modest increase in the production of IL-6, IL-1 beta and TNF-alpha, although no major difference was detected between subjects with or without hypersensitivity.	Sulfamethoxazole	20-23	interleukin 1 beta	Homo sapiens	84-93
8292668-9	1993	An excess of interleukin 1 beta abolished the inhibition of cytokine binding by methotrexate.	Methotrexate	80-92	interleukin 1 beta	Homo sapiens	13-31
8292668-11	1993	Our results demonstrate that methotrexate blocks the interleukin 1 beta-interleukin 1 receptor pathway.	Methotrexate	29-41	interleukin 1 beta	Homo sapiens	53-71
8403509-3	1993	Given that fever is often a prominent feature of hypersensitivity, we also assessed whether SMX or SMX-HA could induce the in vitro production of IL-1 beta, IL-6 or tumour necrosis factor-alpha (TNF-alpha) by PBMC.	Sulfamethoxazole	92-95	interleukin 1 beta	Homo sapiens	146-155
8292668-0	1993	Mechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells.	Methotrexate	23-35	interleukin 1 beta	Homo sapiens	99-117
8292668-0	1993	Mechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells.	Methotrexate	64-76	interleukin 1 beta	Homo sapiens	99-117
8292668-5	1993	It has been demonstrated that methotrexate has no influence on the interleukin 1 synthesis, so we focused our attention on the ability of methotrexate to interfere with the binding of interleukin 1 beta to the interleukin 1 receptor.	Methotrexate	138-150	interleukin 1 beta	Homo sapiens	184-202
8292668-7	1993	Methotrexate led to an astonishing decrease in the binding of interleukin 1 beta to the interleukin 1 receptor of peripheral blood cells, whereas methylprednisolone and indomethacin were not inhibitory.	Methotrexate	0-12	interleukin 1 beta	Homo sapiens	62-80
8275059-5	1993	Peptidoglycan and teichoic acid induced TNF, IL-1, and IL-6 in a concentration-dependent manner.	Teichoic Acids	18-31	interleukin 1 beta	Homo sapiens	45-49
8275059-6	1993	Teichoic acid was a weaker inducer than peptidoglycan, especially for IL-1.	Teichoic Acids	0-13	interleukin 1 beta	Homo sapiens	70-74
7901310-5	1993	However, at all doses of endotoxin from 1 pg/ml to 1 microgram/ml, the addition of taxol resulted in a 50% to 100% increase in IL-1-beta release (p &lt; 0.001) and a 25% to 50% increase in TNF-alpha release (p &lt; 0.01).	Paclitaxel	83-88	interleukin 1 beta	Homo sapiens	127-136
8225567-8	1993	Serine proteolysis may constitute a degradative pathway for excess precursor, which, if interfered with, could result in release of the higher-molecular-weight forms of IL-1 beta.	Serine	0-6	interleukin 1 beta	Homo sapiens	169-178
8408238-0	1993	Role of glucose in interleukin-1 beta production by lipopolysaccharide-activated human monocytes.	Glucose	8-15	interleukin 1 beta	Homo sapiens	19-37
8408238-2	1993	This study was undertaken to investigate the role of glucose in IL-1 beta production by these cells.	Glucose	53-60	interleukin 1 beta	Homo sapiens	64-73
8408238-3	1993	IL-1 beta was produced in a dose-dependent manner to glucose concentration in the culture medium.	Glucose	53-60	interleukin 1 beta	Homo sapiens	0-9
8408238-5	1993	The inhibition of the uptake of (3H)2-deoxyglucose by either 10 microM cytochalasin B or phloretin, added at the time of monocyte activation, was accompanied by significant reduction in ATP/ADP ratio and the inhibition of the production of IL-1 beta by activated monocytes.	(3h)2-deoxyglucose	32-50	interleukin 1 beta	Homo sapiens	240-249
8408238-5	1993	The inhibition of the uptake of (3H)2-deoxyglucose by either 10 microM cytochalasin B or phloretin, added at the time of monocyte activation, was accompanied by significant reduction in ATP/ADP ratio and the inhibition of the production of IL-1 beta by activated monocytes.	Cytochalasin B	71-85	interleukin 1 beta	Homo sapiens	240-249
8408238-5	1993	The inhibition of the uptake of (3H)2-deoxyglucose by either 10 microM cytochalasin B or phloretin, added at the time of monocyte activation, was accompanied by significant reduction in ATP/ADP ratio and the inhibition of the production of IL-1 beta by activated monocytes.	Phloretin	89-98	interleukin 1 beta	Homo sapiens	240-249
8408238-8	1993	These data suggest that 1) glucose is required for LPS-induced IL-1 beta production by monocytes; 2) glucose is the major source of ATP for IL-1 beta production; 3) glucose transporter (GLUT 1) does not control the export of IL-1 beta.	Glucose	27-34	interleukin 1 beta	Homo sapiens	63-72
8408238-8	1993	These data suggest that 1) glucose is required for LPS-induced IL-1 beta production by monocytes; 2) glucose is the major source of ATP for IL-1 beta production; 3) glucose transporter (GLUT 1) does not control the export of IL-1 beta.	Glucose	101-108	interleukin 1 beta	Homo sapiens	140-149
8408238-8	1993	These data suggest that 1) glucose is required for LPS-induced IL-1 beta production by monocytes; 2) glucose is the major source of ATP for IL-1 beta production; 3) glucose transporter (GLUT 1) does not control the export of IL-1 beta.	Glucose	101-108	interleukin 1 beta	Homo sapiens	140-149
8408238-8	1993	These data suggest that 1) glucose is required for LPS-induced IL-1 beta production by monocytes; 2) glucose is the major source of ATP for IL-1 beta production; 3) glucose transporter (GLUT 1) does not control the export of IL-1 beta.	Adenosine Triphosphate	132-135	interleukin 1 beta	Homo sapiens	140-149
8408238-8	1993	These data suggest that 1) glucose is required for LPS-induced IL-1 beta production by monocytes; 2) glucose is the major source of ATP for IL-1 beta production; 3) glucose transporter (GLUT 1) does not control the export of IL-1 beta.	Adenosine Triphosphate	132-135	interleukin 1 beta	Homo sapiens	140-149
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	213-240	interleukin 1 beta	Homo sapiens	72-90
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	213-240	interleukin 1 beta	Homo sapiens	92-101
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	242-246	interleukin 1 beta	Homo sapiens	72-90
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	242-246	interleukin 1 beta	Homo sapiens	92-101
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	Acetylcysteine	252-268	interleukin 1 beta	Homo sapiens	72-90
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	Acetylcysteine	252-268	interleukin 1 beta	Homo sapiens	92-101
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	Acetylcysteine	270-273	interleukin 1 beta	Homo sapiens	72-90
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	Acetylcysteine	270-273	interleukin 1 beta	Homo sapiens	92-101
7901310-6	1993	In contrast, taxol caused a reduction in intracellular pro-IL-1-beta levels.	Paclitaxel	13-18	interleukin 1 beta	Homo sapiens	59-68
7901310-7	1993	Kinetic studies demonstrated that taxol enhanced IL-1-beta release by mononuclear cells at all time points tested from 4.5 hours to 18 hours after stimulation.	Paclitaxel	34-39	interleukin 1 beta	Homo sapiens	49-58
7691182-1	1993	Interleukin 1 (IL-1) induces prostanoid biosynthesis in endothelial cells by promoting cyclooxygenase expression, but little is known about its activity on the biosynthesis of hydroxyeicosatetraenoic acids (HETEs).	Prostaglandins	29-39	interleukin 1 beta	Homo sapiens	15-19
8260535-3	1993	Both dexamethasone and IL-4 dose-dependently inhibited IL-1 beta mRNA and IL-1 beta protein synthesis after stimulation with LPS (300 ng/ml); maximal inhibition of 80-90% was achieved.	Dexamethasone	5-18	interleukin 1 beta	Homo sapiens	55-64
8260535-3	1993	Both dexamethasone and IL-4 dose-dependently inhibited IL-1 beta mRNA and IL-1 beta protein synthesis after stimulation with LPS (300 ng/ml); maximal inhibition of 80-90% was achieved.	Dexamethasone	5-18	interleukin 1 beta	Homo sapiens	74-83
8260535-6	1993	When human monocytes were preincubated for 1 h with IFN-gamma (100 U/ml) prior to the addition of dexamethasone (10(-6) M) and prior to the stimulation with LPS, the dexamethasone-mediated inhibition of IL-1 beta mRNA and IL-1 beta protein synthesis was totally neutralized by IFN-gamma.	Dexamethasone	166-179	interleukin 1 beta	Homo sapiens	203-212
8260535-6	1993	When human monocytes were preincubated for 1 h with IFN-gamma (100 U/ml) prior to the addition of dexamethasone (10(-6) M) and prior to the stimulation with LPS, the dexamethasone-mediated inhibition of IL-1 beta mRNA and IL-1 beta protein synthesis was totally neutralized by IFN-gamma.	Dexamethasone	166-179	interleukin 1 beta	Homo sapiens	222-231
8413223-3	1993	Mutation of the NF-kappa B site in the context of the IL-1 beta promoter reduced the responsiveness of the IL-1 beta promoter to various inducers, including phorbol ester, Sendai virus, poly(rI-rC), and IL-1 beta.	Phorbol Esters	157-170	interleukin 1 beta	Homo sapiens	54-63
8413223-3	1993	Mutation of the NF-kappa B site in the context of the IL-1 beta promoter reduced the responsiveness of the IL-1 beta promoter to various inducers, including phorbol ester, Sendai virus, poly(rI-rC), and IL-1 beta.	Phorbol Esters	157-170	interleukin 1 beta	Homo sapiens	107-116
8413223-3	1993	Mutation of the NF-kappa B site in the context of the IL-1 beta promoter reduced the responsiveness of the IL-1 beta promoter to various inducers, including phorbol ester, Sendai virus, poly(rI-rC), and IL-1 beta.	Phorbol Esters	157-170	interleukin 1 beta	Homo sapiens	107-116
8413223-5	1993	When multiple copies of the IL-1 beta NF-kappa B site were linked to an enhancerless simian virus 40 promoter, this element was able to mediate phorbol ester- or lipopolysaccharide-inducible gene expression.	Phorbol Esters	144-157	interleukin 1 beta	Homo sapiens	28-37
8309727-3	1993	The authors reported here the effects of antibiotics which penetrate inside the cells, such as quinolones and macrolides, on the capacity of blood monocytes to produce IL-I alpha, IL-1 beta, TNF alpha and IL-6 in response to endotoxin.	Quinolones	95-105	interleukin 1 beta	Homo sapiens	180-189
8309727-3	1993	The authors reported here the effects of antibiotics which penetrate inside the cells, such as quinolones and macrolides, on the capacity of blood monocytes to produce IL-I alpha, IL-1 beta, TNF alpha and IL-6 in response to endotoxin.	Macrolides	110-120	interleukin 1 beta	Homo sapiens	180-189
8309727-4	1993	Antibiotics can exert a differential effect on cytokine production: in fact, quinolones, in vitro, at concentrations higher than 25 micrograms/ml decreased IL-1 beta, TNF alpha and IL-6, while they do not modify IL-1 alpha.	Quinolones	77-87	interleukin 1 beta	Homo sapiens	156-165
7691182-9	1993	Indomethacin and ETYA completely suppressed prostanoids, 11-HETE and 15-HETE formation in resting and IL-1 beta-activated cells.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	102-111
7691182-9	1993	Indomethacin and ETYA completely suppressed prostanoids, 11-HETE and 15-HETE formation in resting and IL-1 beta-activated cells.	5,8,11,14-Eicosatetraynoic Acid	17-21	interleukin 1 beta	Homo sapiens	102-111
7691182-9	1993	Indomethacin and ETYA completely suppressed prostanoids, 11-HETE and 15-HETE formation in resting and IL-1 beta-activated cells.	15-Hete	69-76	interleukin 1 beta	Homo sapiens	102-111
7691182-1	1993	Interleukin 1 (IL-1) induces prostanoid biosynthesis in endothelial cells by promoting cyclooxygenase expression, but little is known about its activity on the biosynthesis of hydroxyeicosatetraenoic acids (HETEs).	Hydroxyeicosatetraenoic Acids	207-212	interleukin 1 beta	Homo sapiens	15-19
7691182-11	1993	Overall, these results provide evidence that in human endothelial cells IL-1 beta increases 15-HETE production.	15-Hete	92-99	interleukin 1 beta	Homo sapiens	72-81
7691182-2	1993	We studied the effect of human recombinant IL-1 beta on the conversion of arachidonic acid (AA) to 15-HETE, a powerful inhibitor of the biosynthesis of proinflammatory eicosanoids.	Arachidonic Acid	74-90	interleukin 1 beta	Homo sapiens	43-52
7691182-2	1993	We studied the effect of human recombinant IL-1 beta on the conversion of arachidonic acid (AA) to 15-HETE, a powerful inhibitor of the biosynthesis of proinflammatory eicosanoids.	15-Hete	99-106	interleukin 1 beta	Homo sapiens	43-52
7691182-2	1993	We studied the effect of human recombinant IL-1 beta on the conversion of arachidonic acid (AA) to 15-HETE, a powerful inhibitor of the biosynthesis of proinflammatory eicosanoids.	Eicosanoids	168-179	interleukin 1 beta	Homo sapiens	43-52
7691182-5	1993	Untreated cells produced little amounts of 15-HETE (6 +/- 3 pmol/10(6) cells), but IL-1 beta treated cells increased 15-HETE formation in a dose-dependent manner (4-5-fold at 10 U/ml IL-1).	15-Hete	117-124	interleukin 1 beta	Homo sapiens	83-92
7691182-5	1993	Untreated cells produced little amounts of 15-HETE (6 +/- 3 pmol/10(6) cells), but IL-1 beta treated cells increased 15-HETE formation in a dose-dependent manner (4-5-fold at 10 U/ml IL-1).	15-Hete	117-124	interleukin 1 beta	Homo sapiens	83-87
8311924-5	1993	RESULTS: IL-1 beta, PMA, and ionomycin all stimulated decidual PGE2 and TXB2 production as expected.	Dinoprostone	63-67	interleukin 1 beta	Homo sapiens	9-18
8242337-9	1993	Longer term treatment with IL-1 beta in forskolin pre-treated astrocytes enhanced the calcium response to quisqualate stimulation, a glutamate neurotransmitter receptor agonist.	Colforsin	40-49	interleukin 1 beta	Homo sapiens	27-36
8242337-9	1993	Longer term treatment with IL-1 beta in forskolin pre-treated astrocytes enhanced the calcium response to quisqualate stimulation, a glutamate neurotransmitter receptor agonist.	Calcium	86-93	interleukin 1 beta	Homo sapiens	27-36
8242337-9	1993	Longer term treatment with IL-1 beta in forskolin pre-treated astrocytes enhanced the calcium response to quisqualate stimulation, a glutamate neurotransmitter receptor agonist.	Quisqualic Acid	106-117	interleukin 1 beta	Homo sapiens	27-36
8311924-5	1993	RESULTS: IL-1 beta, PMA, and ionomycin all stimulated decidual PGE2 and TXB2 production as expected.	Thromboxane B2	72-76	interleukin 1 beta	Homo sapiens	9-18
8216418-0	1993	Reduction of leukocyte and interleukin-1 beta concentrations in the synovial fluid of rheumatoid arthritis patients treated with methotrexate.	Methotrexate	129-141	interleukin 1 beta	Homo sapiens	27-45
8216418-8	1993	In contrast, the number of leukocytes, the number and proportion of neutrophils, and the concentration of IL-1 beta in the SF of patients treated with MTX were reduced.	Methotrexate	151-154	interleukin 1 beta	Homo sapiens	106-115
8216423-5	1993	RESULTS: Treatment of synovial fibroblasts with IL-1 beta and TNF alpha resulted in the production of an activity which induced intracellular calcium mobilization in peripheral blood neutrophils.	Calcium	142-149	interleukin 1 beta	Homo sapiens	48-57
8102321-3	1993	The inhibition is strong in cancer patients, because PGE2 is formed in many cancer cells and its formation is stimulated by IL-1 beta.	Dinoprostone	53-57	interleukin 1 beta	Homo sapiens	124-133
8102321-4	1993	The release of histamine is also stimulated by IL-1 beta.	Histamine	15-24	interleukin 1 beta	Homo sapiens	47-56
8359908-3	1993	SdJ5, at a concentration equal to or greater than 3 micrograms/ml, specifically inhibited TNF-alpha and interleukin-1 beta production by hPBMC stimulated with every type of LPS and lipid A assessed.	sdj5	0-4	interleukin 1 beta	Homo sapiens	104-122
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	interleukin 1 beta	Homo sapiens	259-282
8311923-0	1993	Evidence for a common mechanism of action of interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor on prostaglandin production in human chorion cells.	Prostaglandins	125-138	interleukin 1 beta	Homo sapiens	45-92
8311923-1	1993	PROBLEM: Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue.	Prostaglandins	35-49	interleukin 1 beta	Homo sapiens	65-83
8311923-1	1993	PROBLEM: Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue.	Prostaglandins	35-49	interleukin 1 beta	Homo sapiens	85-94
8311923-1	1993	PROBLEM: Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue.	Prostaglandins	35-48	interleukin 1 beta	Homo sapiens	65-83
8311923-1	1993	PROBLEM: Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue.	Prostaglandins	35-48	interleukin 1 beta	Homo sapiens	85-94
8311923-2	1993	METHODS: IL-1 beta, TNF alpha, and EGF induced a concentration-related stimulation of prostaglandin E2 (PGE2) biosynthesis in human chorion cells, and this stimulation was enhanced by the addition of exogenous arachidonic acid.	Dinoprostone	86-102	interleukin 1 beta	Homo sapiens	9-18
8311923-2	1993	METHODS: IL-1 beta, TNF alpha, and EGF induced a concentration-related stimulation of prostaglandin E2 (PGE2) biosynthesis in human chorion cells, and this stimulation was enhanced by the addition of exogenous arachidonic acid.	Dinoprostone	104-108	interleukin 1 beta	Homo sapiens	9-18
8311923-2	1993	METHODS: IL-1 beta, TNF alpha, and EGF induced a concentration-related stimulation of prostaglandin E2 (PGE2) biosynthesis in human chorion cells, and this stimulation was enhanced by the addition of exogenous arachidonic acid.	Arachidonic Acid	210-226	interleukin 1 beta	Homo sapiens	9-18
8311923-3	1993	RESULTS: Protein synthesis inhibition with cycloheximide or actinomycin D resulted in complete abrogation of the stimulation of PGE2 production by IL-1 beta, TNF alpha, and EGF.	Cycloheximide	43-56	interleukin 1 beta	Homo sapiens	147-156
8311923-3	1993	RESULTS: Protein synthesis inhibition with cycloheximide or actinomycin D resulted in complete abrogation of the stimulation of PGE2 production by IL-1 beta, TNF alpha, and EGF.	Dactinomycin	60-73	interleukin 1 beta	Homo sapiens	147-156
8311923-3	1993	RESULTS: Protein synthesis inhibition with cycloheximide or actinomycin D resulted in complete abrogation of the stimulation of PGE2 production by IL-1 beta, TNF alpha, and EGF.	Dinoprostone	128-132	interleukin 1 beta	Homo sapiens	147-156
8311923-5	1993	CONCLUSIONS: It is suggested that IL-1 beta, TNF alpha, and EGF all act to stimulate human chorion PGE2 production primarily via induction of prostaglandin endoperoxide synthase activity.	Dinoprostone	99-103	interleukin 1 beta	Homo sapiens	34-43
8134164-5	1993	When treated with 12-o-tetradecanoylphorbol 13-acetate, KP-1 cells became tightly adherent, showed the enhanced reactivity for alpha-naphtyl butyrate esterase, and produced several monokines such as IL-1 beta, tumor necrosis factor-alpha, and macrophage colony-stimulating factor.	Tetradecanoylphorbol Acetate	18-54	interleukin 1 beta	Homo sapiens	199-237
8248272-2	1993	HUVEC which had been preincubated with LPS, interleukin-1 alpha (IL-1 alpha), IL-1 beta, tumor necrosis factor (TNF alpha), or interferon-gamma (IFN-gamma) produced more PGI2 than control cells in response to thrombin.	Epoprostenol	170-174	interleukin 1 beta	Homo sapiens	78-87
8394358-6	1993	In particular, a Lys97--&gt;Val mutation produces substantially more IL-1 beta in inclusion bodies than the wild type (61 versus 8%) despite generating a protein more thermodynamically stable than wild type.	Valine	28-31	interleukin 1 beta	Homo sapiens	69-78
8126018-3	1993	IL-1 beta secreted from human monocytes/macrophages on Biomer, polydimethylsiloxane (PDMS), Dacron, polyethylene, expanded polytetrafluoroethylene, and control polystyrene with and without the preadsorption of physiological concentrations of human IgG, fibrinogen, and/or fibronectin was assayed.	baysilon	63-83	interleukin 1 beta	Homo sapiens	0-9
8126018-3	1993	IL-1 beta secreted from human monocytes/macrophages on Biomer, polydimethylsiloxane (PDMS), Dacron, polyethylene, expanded polytetrafluoroethylene, and control polystyrene with and without the preadsorption of physiological concentrations of human IgG, fibrinogen, and/or fibronectin was assayed.	baysilon	85-89	interleukin 1 beta	Homo sapiens	0-9
8126018-3	1993	IL-1 beta secreted from human monocytes/macrophages on Biomer, polydimethylsiloxane (PDMS), Dacron, polyethylene, expanded polytetrafluoroethylene, and control polystyrene with and without the preadsorption of physiological concentrations of human IgG, fibrinogen, and/or fibronectin was assayed.	Polyethylene Terephthalates	92-98	interleukin 1 beta	Homo sapiens	0-9
8126018-3	1993	IL-1 beta secreted from human monocytes/macrophages on Biomer, polydimethylsiloxane (PDMS), Dacron, polyethylene, expanded polytetrafluoroethylene, and control polystyrene with and without the preadsorption of physiological concentrations of human IgG, fibrinogen, and/or fibronectin was assayed.	Polyethylene	100-112	interleukin 1 beta	Homo sapiens	0-9
8126018-3	1993	IL-1 beta secreted from human monocytes/macrophages on Biomer, polydimethylsiloxane (PDMS), Dacron, polyethylene, expanded polytetrafluoroethylene, and control polystyrene with and without the preadsorption of physiological concentrations of human IgG, fibrinogen, and/or fibronectin was assayed.	Polytetrafluoroethylene	123-146	interleukin 1 beta	Homo sapiens	0-9
8126018-3	1993	IL-1 beta secreted from human monocytes/macrophages on Biomer, polydimethylsiloxane (PDMS), Dacron, polyethylene, expanded polytetrafluoroethylene, and control polystyrene with and without the preadsorption of physiological concentrations of human IgG, fibrinogen, and/or fibronectin was assayed.	Polystyrenes	160-171	interleukin 1 beta	Homo sapiens	0-9
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	19-50	interleukin 1 beta	Homo sapiens	94-103
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	52-55	interleukin 1 beta	Homo sapiens	94-103
8245177-2	1993	Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine.	Staurosporine	172-185	interleukin 1 beta	Homo sapiens	81-85
8245177-2	1993	Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine.	Staurosporine	172-185	interleukin 1 beta	Homo sapiens	109-113
8164209-0	1993	Effect of 1,25-dihydroxyvitamin D3 on interleukin 1 beta actions and cell growth in human synovial fibroblast cultures.	Calcitriol	10-34	interleukin 1 beta	Homo sapiens	38-56
8164209-1	1993	OBJECTIVE: To investigate the effects of vitamin D3 [1,25-(OH)2D3] metabolites on interleukin 1 beta (IL-1 beta) stimulated secretory activities and on the proliferation of human synovial fibroblasts in culture.	Cholecalciferol	41-51	interleukin 1 beta	Homo sapiens	82-100
8164209-1	1993	OBJECTIVE: To investigate the effects of vitamin D3 [1,25-(OH)2D3] metabolites on interleukin 1 beta (IL-1 beta) stimulated secretory activities and on the proliferation of human synovial fibroblasts in culture.	Cholecalciferol	41-51	interleukin 1 beta	Homo sapiens	102-111
8164209-1	1993	OBJECTIVE: To investigate the effects of vitamin D3 [1,25-(OH)2D3] metabolites on interleukin 1 beta (IL-1 beta) stimulated secretory activities and on the proliferation of human synovial fibroblasts in culture.	Calcitriol	53-65	interleukin 1 beta	Homo sapiens	82-100
8164209-1	1993	OBJECTIVE: To investigate the effects of vitamin D3 [1,25-(OH)2D3] metabolites on interleukin 1 beta (IL-1 beta) stimulated secretory activities and on the proliferation of human synovial fibroblasts in culture.	Calcitriol	53-65	interleukin 1 beta	Homo sapiens	102-111
8164209-5	1993	RESULTS: 1,25-(OH)2D3 inhibited the effects of IL-1 beta on PGE production by up to 90%, with half maximal inhibition at 2.0 x 10(-10) M. Inhibitory effects on stimulated collagenase and HA production and cell growth were also found but were less marked.	Calcitriol	9-21	interleukin 1 beta	Homo sapiens	47-56
8164209-5	1993	RESULTS: 1,25-(OH)2D3 inhibited the effects of IL-1 beta on PGE production by up to 90%, with half maximal inhibition at 2.0 x 10(-10) M. Inhibitory effects on stimulated collagenase and HA production and cell growth were also found but were less marked.	Prostaglandins E	60-63	interleukin 1 beta	Homo sapiens	47-56
8352255-0	1993	Comparison of first use and reuse of cuprophan membranes on interleukin-1 receptor antagonist and interleukin-1 beta production by blood mononuclear cells.	cuprammonium cellulose	37-46	interleukin 1 beta	Homo sapiens	98-116
8334682-3	1993	Increased intracellular interleukin-1 alpha (IL-1 alpha) and IL-1 beta were not detected until 8 h after exposure to L-MTP-PE.	L-MTP-PE	117-125	interleukin 1 beta	Homo sapiens	61-70
8334682-5	1993	Enhanced expression of IL-1 alpha and IL-1 beta mRNA was inhibited at 4 h but not 24 h when monocytes were incubated with L-MTP-PE plus anti-TNF compared with L-MTP-PE alone.	L-MTP-PE	122-130	interleukin 1 beta	Homo sapiens	38-47
8334682-5	1993	Enhanced expression of IL-1 alpha and IL-1 beta mRNA was inhibited at 4 h but not 24 h when monocytes were incubated with L-MTP-PE plus anti-TNF compared with L-MTP-PE alone.	L-MTP-PE	159-167	interleukin 1 beta	Homo sapiens	38-47
8360592-4	1993	RA differentially modulated the expression of interleukin-1 beta (IL-1 beta), IL-6, and IL-8 mRNAs depending on the inducing stimulus.	Tretinoin	0-2	interleukin 1 beta	Homo sapiens	46-64
8405744-3	1993	Here we investigated the effects of interleukin-1 receptor antagonism on insulin and glucagon release of rat, mouse and human islets exposed to recombinant human interleukin-1 beta, and on interleukin-1 beta induced changes in blood glucose, serum insulin and serum glucagon levels in Wistar Kyoto rats.	Glucose	233-240	interleukin 1 beta	Homo sapiens	189-207
7505000-3	1993	The expression of tumour necrosis factor (TNF)alpha, TNF beta interleukin (IL)-2 and interferon (IFN)gamma was inhibited by PTX in a dose-dependent manner, whereas expression of IL-1 alpha, IL-1 beta, and IL-6 was unaffected at concentrations up to 300 microM of PTX.	Pentoxifylline	124-127	interleukin 1 beta	Homo sapiens	190-199
8360592-4	1993	RA differentially modulated the expression of interleukin-1 beta (IL-1 beta), IL-6, and IL-8 mRNAs depending on the inducing stimulus.	Tretinoin	0-2	interleukin 1 beta	Homo sapiens	66-75
8360592-5	1993	While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed.	Tetradecanoylphorbol Acetate	6-31	interleukin 1 beta	Homo sapiens	40-49
8360592-7	1993	IL-1-induced de novo synthesis of IL-6 protein and secretion of biologically active IL-6 were also inhibited by RA.	Tretinoin	112-114	interleukin 1 beta	Homo sapiens	0-4
8360592-8	1993	The inhibition pattern of RA was different from that of dexamethasone, which inhibited both IL-1 and LPS effects.	Tretinoin	26-28	interleukin 1 beta	Homo sapiens	92-96
8360592-8	1993	The inhibition pattern of RA was different from that of dexamethasone, which inhibited both IL-1 and LPS effects.	Dexamethasone	56-69	interleukin 1 beta	Homo sapiens	92-96
8411809-0	1993	[Demonstration of interleukin-1 (IL-1) as an autocrine growth inhibitor in renal cancer cell line, TC-1].	TC 1	99-103	interleukin 1 beta	Homo sapiens	18-37
8411809-4	1993	Flow cytometric cell cycle analysis by double staining method with propidium iodide and Proliferating cell nuclear antigen (PCNA) disclosed IL-1 beta caused cell accumulation at G1 phase.	Propidium	67-83	interleukin 1 beta	Homo sapiens	140-149
7686394-7	1993	Iloprost abolished LPS-induced TNF-alpha secretion by THP-1 cells and inhibited IL-1 beta secretion by 45%.	Iloprost	0-8	interleukin 1 beta	Homo sapiens	80-89
8304239-4	1993	Regarding the synthesis of these prostaglandins, IL-1 beta was again more potent than IL-1 alpha.	Prostaglandins	33-47	interleukin 1 beta	Homo sapiens	49-58
7688473-9	1993	Exogenous NO either as a gaseous solution or released by a NO donor, sodium nitroprusside or glyceryl trinitrate, increased COX activity in the interleukin 1 beta-stimulated fibroblasts by 5-fold; these effects were abolished by coincubation with hemoglobin (10 microM), which binds and inactivates NO, but not by methylene blue, an inhibitor of the soluble guanylate cyclase.	Nitroprusside	69-89	interleukin 1 beta	Homo sapiens	144-162
7688473-9	1993	Exogenous NO either as a gaseous solution or released by a NO donor, sodium nitroprusside or glyceryl trinitrate, increased COX activity in the interleukin 1 beta-stimulated fibroblasts by 5-fold; these effects were abolished by coincubation with hemoglobin (10 microM), which binds and inactivates NO, but not by methylene blue, an inhibitor of the soluble guanylate cyclase.	Nitroglycerin	93-112	interleukin 1 beta	Homo sapiens	144-162
7688473-9	1993	Exogenous NO either as a gaseous solution or released by a NO donor, sodium nitroprusside or glyceryl trinitrate, increased COX activity in the interleukin 1 beta-stimulated fibroblasts by 5-fold; these effects were abolished by coincubation with hemoglobin (10 microM), which binds and inactivates NO, but not by methylene blue, an inhibitor of the soluble guanylate cyclase.	Methylene Blue	314-328	interleukin 1 beta	Homo sapiens	144-162
8325511-6	1993	Porcine IL-1 beta is down-regulated by dexamethasone, polymyxin B, and IL-4 in a fashion kinetically similar to the other reported species.	Dexamethasone	39-52	interleukin 1 beta	Homo sapiens	8-17
7686394-8	1993	In keeping with this, iloprost reduced levels of TNF-alpha and IL-1 beta mRNA in LPS-challenged cells.	Iloprost	22-30	interleukin 1 beta	Homo sapiens	63-72
7689587-4	1993	In this report, we present evidence for the production of NO, as measured by the production of nitrite, in highly enriched human fetal astrocyte cultures stimulated with IL-1 beta.	Nitrites	95-102	interleukin 1 beta	Homo sapiens	170-179
7504587-5	1993	RESULTS: Stimulation of SGHEC-7 cells with IL-1 beta or TNF alpha (each at 1-30 ng.ml-1) caused them to express the inducible NO synthase, an effect that was prevented by dexamethasone.	Dexamethasone	171-184	interleukin 1 beta	Homo sapiens	43-52
7686496-10	1993	MECIF activity, TNF alpha, and IL-1 beta significantly increased prostacyclin secretion whereas TGF beta, IL-6, and IFN-gamma showed no significant effect.	Epoprostenol	65-77	interleukin 1 beta	Homo sapiens	31-40
7686496-11	1993	Indomethacin did not significantly modify ELAM-1 induction and reduced in a nonsignificant manner the antiproliferative effect of MECIF activity, TNF alpha, IL-1 beta, and TGF beta.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	157-166
7686496-13	1993	The cyclooxygenase pathway of arachidonic acid metabolism could be involved in the growth inhibitory action of MECIF activity, TNF alpha, IL-1 beta, and TGF beta but an additional putative pathway might also be involved.	Arachidonic Acid	30-46	interleukin 1 beta	Homo sapiens	138-147
8331300-12	1993	Hence, these results provide further evidence of the augmentation of immune responses by tetracyclines and support the hypothesis that epidermal IL-1 plays a physiologic role in wound healing.	Tetracyclines	89-102	interleukin 1 beta	Homo sapiens	145-149
8325995-0	1993	Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells.	Histamine	0-9	interleukin 1 beta	Homo sapiens	46-50
8325995-3	1993	We therefore investigated whether histamine modulated the synthesis of IL-1 beta.	Histamine	34-43	interleukin 1 beta	Homo sapiens	71-80
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Histamine	72-81	interleukin 1 beta	Homo sapiens	19-28
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Histamine	72-81	interleukin 1 beta	Homo sapiens	232-241
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Cimetidine	119-129	interleukin 1 beta	Homo sapiens	19-28
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Cimetidine	119-129	interleukin 1 beta	Homo sapiens	232-241
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Histamine	171-180	interleukin 1 beta	Homo sapiens	19-28
8325995-6	1993	IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Histamine	171-180	interleukin 1 beta	Homo sapiens	232-241
8325995-8	1993	Indomethacin, a cyclooxygenase inhibitor, significantly reduced IL-1 alpha-induced IL-1 beta synthesis, but had no effect on the histamine-mediated increase in IL-1 alpha-induced IL-1 beta synthesis.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	83-92
8325995-9	1993	Histamine (10(-5) M) enhanced and sustained IL-1 beta mRNA levels in IL-1 alpha-stimulated PBMC.	Histamine	0-9	interleukin 1 beta	Homo sapiens	44-53
8325995-10	1993	However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation.	Histamine	9-18	interleukin 1 beta	Homo sapiens	27-36
8325995-10	1993	However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation.	Histamine	9-18	interleukin 1 beta	Homo sapiens	122-131
8325995-10	1993	However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation.	Histamine	84-93	interleukin 1 beta	Homo sapiens	27-36
8325995-10	1993	However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation.	Histamine	84-93	interleukin 1 beta	Homo sapiens	122-131
8325995-12	1993	These results suggest that mast cells may sustain chronic inflammatory processes by upregulating self-induction of IL-1 through histamine release.	Histamine	128-137	interleukin 1 beta	Homo sapiens	115-119
7689587-6	1993	The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma &gt; TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines.	Nitrites	22-29	interleukin 1 beta	Homo sapiens	4-13
8357951-0	1993	Eicosapentaenoic acid potentiates the production of nitric oxide evoked by interleukin-1 beta in cultured vascular smooth muscle cells.	Eicosapentaenoic Acid	0-21	interleukin 1 beta	Homo sapiens	75-93
8357951-0	1993	Eicosapentaenoic acid potentiates the production of nitric oxide evoked by interleukin-1 beta in cultured vascular smooth muscle cells.	Nitric Oxide	52-64	interleukin 1 beta	Homo sapiens	75-93
8357951-1	1993	Experiments were designed to determine whether the omega 3-unsaturated fatty acid eicosapentaenoic acid affects the production of nitric oxide evoked by interleukin-1 beta in cultured vascular smooth muscle cells.	Eicosapentaenoic Acid	82-103	interleukin 1 beta	Homo sapiens	153-171
8357951-1	1993	Experiments were designed to determine whether the omega 3-unsaturated fatty acid eicosapentaenoic acid affects the production of nitric oxide evoked by interleukin-1 beta in cultured vascular smooth muscle cells.	Nitric Oxide	130-142	interleukin 1 beta	Homo sapiens	153-171
8357951-2	1993	Incubation of cultured rat or human aortic smooth muscle cells with interleukin-1 beta evoked a time- and concentration-dependent release of nitrite, an oxidation product of nitric oxide.	Nitrites	141-148	interleukin 1 beta	Homo sapiens	68-86
8357951-2	1993	Incubation of cultured rat or human aortic smooth muscle cells with interleukin-1 beta evoked a time- and concentration-dependent release of nitrite, an oxidation product of nitric oxide.	Nitric Oxide	174-186	interleukin 1 beta	Homo sapiens	68-86
8357951-3	1993	The exposure of cells to interleukin-1 beta in combination with eicosapentaenoic acid caused a significantly larger production of nitrite than that evoked by the cytokine alone.	Nitrites	130-137	interleukin 1 beta	Homo sapiens	25-43
8357951-5	1993	The production of nitrite evoked by equieffective concentrations of interleukin-1 beta in the presence and absence of eicosapentaenoic acid were inhibited to a similar extent by nitro L-arginine (an inhibitor of nitric oxide synthase), transforming growth factor beta 1, platelet-derived growth factorAB and thrombin.	Nitrites	18-25	interleukin 1 beta	Homo sapiens	68-86
8357951-6	1993	The addition of interleukin-1 beta-activated smooth muscle cells to suspensions of washed and indomethacin-treated platelets inhibited the aggregation caused by thrombin.	Indomethacin	94-106	interleukin 1 beta	Homo sapiens	16-34
8357951-10	1993	These observations suggest that eicosapentaenoic acid potentiates the production of nitric oxide evoked by interleukin-1 beta in vascular smooth muscle.	Eicosapentaenoic Acid	32-53	interleukin 1 beta	Homo sapiens	107-125
8357951-10	1993	These observations suggest that eicosapentaenoic acid potentiates the production of nitric oxide evoked by interleukin-1 beta in vascular smooth muscle.	Nitric Oxide	84-96	interleukin 1 beta	Homo sapiens	107-125
7686310-4	1993	The pathways for induction of IL-1 beta and TNF-alpha expression were not suppressed by the persistent MV infection, since IL-1 beta and TNF-alpha could be induced by external stimuli like diacylglycerol analog plus calcium ionophore.	Diglycerides	189-203	interleukin 1 beta	Homo sapiens	30-39
8378543-4	1993	Low levels of IL-1 beta (0.1-1.0 ng/ml) increased PGE2 levels on the fetal side of the membrane, and also increased the production of PGE2 metabolites and PGF2 alpha, suggesting that this cytokine stimulated the decidua as well as the amnion.	Dinoprostone	50-54	interleukin 1 beta	Homo sapiens	14-23
8378543-4	1993	Low levels of IL-1 beta (0.1-1.0 ng/ml) increased PGE2 levels on the fetal side of the membrane, and also increased the production of PGE2 metabolites and PGF2 alpha, suggesting that this cytokine stimulated the decidua as well as the amnion.	Dinoprostone	134-138	interleukin 1 beta	Homo sapiens	14-23
8378543-4	1993	Low levels of IL-1 beta (0.1-1.0 ng/ml) increased PGE2 levels on the fetal side of the membrane, and also increased the production of PGE2 metabolites and PGF2 alpha, suggesting that this cytokine stimulated the decidua as well as the amnion.	Dinoprost	155-159	interleukin 1 beta	Homo sapiens	14-23
8378543-6	1993	Taken together, these results indicate that IL-1 beta was a potent stimulator of the synthesis of prostaglandins by decidua and by amnion, whereas IL-1 alpha only stimulated the amnion.	Prostaglandins	98-112	interleukin 1 beta	Homo sapiens	44-53
8234146-5	1993	PAL significantly inhibited the IL-1 beta production induced by IL-1 alpha or PMA without inhibition of total protein synthesis and cytotoxicity.	protocatechualdehyde	0-3	interleukin 1 beta	Homo sapiens	32-41
8234146-6	1993	A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production.	Staurosporine	36-49	interleukin 1 beta	Homo sapiens	71-80
8234146-6	1993	A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production.	Staurosporine	36-49	interleukin 1 beta	Homo sapiens	200-209
8234146-7	1993	The calcium ionophore A23187 (A23187) potentiated the IL-1 beta production induced by IL-1 alpha.	Calcium	4-11	interleukin 1 beta	Homo sapiens	54-63
8234146-7	1993	The calcium ionophore A23187 (A23187) potentiated the IL-1 beta production induced by IL-1 alpha.	Calcimycin	22-28	interleukin 1 beta	Homo sapiens	54-63
8234146-7	1993	The calcium ionophore A23187 (A23187) potentiated the IL-1 beta production induced by IL-1 alpha.	Calcimycin	30-36	interleukin 1 beta	Homo sapiens	54-63
7686310-4	1993	The pathways for induction of IL-1 beta and TNF-alpha expression were not suppressed by the persistent MV infection, since IL-1 beta and TNF-alpha could be induced by external stimuli like diacylglycerol analog plus calcium ionophore.	Diglycerides	189-203	interleukin 1 beta	Homo sapiens	123-132
7686310-4	1993	The pathways for induction of IL-1 beta and TNF-alpha expression were not suppressed by the persistent MV infection, since IL-1 beta and TNF-alpha could be induced by external stimuli like diacylglycerol analog plus calcium ionophore.	Calcium	216-223	interleukin 1 beta	Homo sapiens	123-132
8316767-0	1993	Modulation of glucocorticosteroid binding in human lymphoid, monocytoid and hepatoma cell lines by inflammatory cytokines interleukin (IL)-1 beta, IL-6 and tumour necrosis factor (TNF)-alpha.	glucocorticosteroid	14-33	interleukin 1 beta	Homo sapiens	122-145
8344702-0	1993	Effect of retinoic acid and vitamin D on the expression of interleukin-1 beta, tumour necrosis factor-alpha and interleukin-6 in the human monocytic cell line U937.	Tretinoin	10-23	interleukin 1 beta	Homo sapiens	59-77
8344702-0	1993	Effect of retinoic acid and vitamin D on the expression of interleukin-1 beta, tumour necrosis factor-alpha and interleukin-6 in the human monocytic cell line U937.	Vitamin D	28-37	interleukin 1 beta	Homo sapiens	59-77
8496597-0	1993	Differential action of cycloheximide and activation stimuli on transcription of tumor necrosis factor-alpha, IL-1 beta, IL-8, and P53 genes in human monocytes.	Cycloheximide	23-36	interleukin 1 beta	Homo sapiens	109-118
7684503-2	1993	We demonstrated that the Mycobacterium tuberculosis cell wall component lipoarabinomannan (LAM) is a very potent inducer of IL-1 beta gene expression in human monocytes and investigated the mechanism of this effect.	lipoarabinomannan	91-94	interleukin 1 beta	Homo sapiens	124-133
7684503-3	1993	We localized the LAM-, lipopolysaccharide (LPS)-, and TNF-alpha-inducible promoter activity to a -131/+15 (positions -131 to +15) DNA fragment of the IL-1 beta gene by deletion analysis and chloramphenicol acetyltransferase assay.	lipoarabinomannan	17-20	interleukin 1 beta	Homo sapiens	150-159
8485713-1	1993	Recently 4 genes (plasminogen activator inhibitor 2, interleukin 1 beta, clone 1, and clone 141) that are transcriptionally or posttranscriptionally responsive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been cloned from a human skin keratinocyte cell line.	Polychlorinated Dibenzodioxins	163-198	interleukin 1 beta	Homo sapiens	53-71
8485713-1	1993	Recently 4 genes (plasminogen activator inhibitor 2, interleukin 1 beta, clone 1, and clone 141) that are transcriptionally or posttranscriptionally responsive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been cloned from a human skin keratinocyte cell line.	Polychlorinated Dibenzodioxins	200-204	interleukin 1 beta	Homo sapiens	53-71
8506955-7	1993	Stimulation of HPMC with combinations of IL-1 beta and TNF-alpha resulted in a synergistic increase in IL-8 release.	hydroxypropylmethylcellulose-lactose matrix	15-19	interleukin 1 beta	Homo sapiens	41-50
8500546-4	1993	Heat shock protein 70 gene was initially down regulated and was induced only after 48 h. The well-differentiated malignant keratinocyte cell line differed in that the c-fos, GADD, SPR1, and IL1-beta genes had several-fold higher induction, but involucrin mRNA was undetectable and fibronectin mRNA was only minimally induced after TPA stimulation.	Tetradecanoylphorbol Acetate	331-334	interleukin 1 beta	Homo sapiens	190-198
7684906-2	1993	The synthesis of NO induced by IL-1 beta was concentration- and time- dependent, occurred after a lag period of approximately 6h and was inhibited by NG-monomethyl-L-arginine, cycloheximide, dexamethasone and hydrocortisone, but not by indomethacin.	omega-N-Methylarginine	150-174	interleukin 1 beta	Homo sapiens	31-40
7684906-2	1993	The synthesis of NO induced by IL-1 beta was concentration- and time- dependent, occurred after a lag period of approximately 6h and was inhibited by NG-monomethyl-L-arginine, cycloheximide, dexamethasone and hydrocortisone, but not by indomethacin.	Cycloheximide	176-189	interleukin 1 beta	Homo sapiens	31-40
7684906-2	1993	The synthesis of NO induced by IL-1 beta was concentration- and time- dependent, occurred after a lag period of approximately 6h and was inhibited by NG-monomethyl-L-arginine, cycloheximide, dexamethasone and hydrocortisone, but not by indomethacin.	Dexamethasone	191-204	interleukin 1 beta	Homo sapiens	31-40
7684906-2	1993	The synthesis of NO induced by IL-1 beta was concentration- and time- dependent, occurred after a lag period of approximately 6h and was inhibited by NG-monomethyl-L-arginine, cycloheximide, dexamethasone and hydrocortisone, but not by indomethacin.	Hydrocortisone	209-223	interleukin 1 beta	Homo sapiens	31-40
7684906-2	1993	The synthesis of NO induced by IL-1 beta was concentration- and time- dependent, occurred after a lag period of approximately 6h and was inhibited by NG-monomethyl-L-arginine, cycloheximide, dexamethasone and hydrocortisone, but not by indomethacin.	Indomethacin	236-248	interleukin 1 beta	Homo sapiens	31-40
7683676-2	1993	TNF alpha (100 units/ml) and IL-1 beta (100 units/ml) stimulated the production of PGE2 and caused a dose-dependent inhibition of up to 54 and 66%, respectively, of the production of type I procollagen.	Dinoprostone	83-87	interleukin 1 beta	Homo sapiens	29-38
7683676-8	1993	These results indicate that TNF alpha and IL-1 beta inhibit the expression of the alpha 1(I) procollagen gene in human lung fibroblasts at the transcriptional level by a PGE2-independent effect as well as through the effect of endogenous fibroblast PGE2 released under the stimulus of the cytokines.	Dinoprostone	170-174	interleukin 1 beta	Homo sapiens	42-51
7683676-8	1993	These results indicate that TNF alpha and IL-1 beta inhibit the expression of the alpha 1(I) procollagen gene in human lung fibroblasts at the transcriptional level by a PGE2-independent effect as well as through the effect of endogenous fibroblast PGE2 released under the stimulus of the cytokines.	Dinoprostone	249-253	interleukin 1 beta	Homo sapiens	42-51
8473757-6	1993	Chrysotile, crocidolite, amosite asbestos, and silica stimulated IL-1 beta and TNF-alpha release and up-regulated their respective mRNA in macrophages or monocytes.	Asbestos, Crocidolite	12-23	interleukin 1 beta	Homo sapiens	65-74
8496911-1	1993	A series of 2"-substituted chalcone derivatives has been found to show potent inhibition of the production of IL-1 beta from human peripheral blood monocytes stimulated with lipopolysaccharide (LPS), with IC50 values in the 0.2-5.0-microM range.	2"-substituted chalcone	12-35	interleukin 1 beta	Homo sapiens	110-119
8218931-2	1993	IL-1 alpha, IL-1 beta and TNF-alpha, but not EGF nor TGF-alpha, stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts.	Dinoprostone	75-91	interleukin 1 beta	Homo sapiens	12-21
8218931-2	1993	IL-1 alpha, IL-1 beta and TNF-alpha, but not EGF nor TGF-alpha, stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts.	Dinoprostone	93-97	interleukin 1 beta	Homo sapiens	12-21
8218931-3	1993	The effect of IL-1 alpha, IL-1 beta and TNF-alpha on PGE2 formation was significantly potentiated by EGF in a dose-dependent manner.	Dinoprostone	53-57	interleukin 1 beta	Homo sapiens	26-35
8218931-4	1993	Similarly, TGF-alpha synergistically potentiated IL-1 beta stimulated PGE2 formation.	Dinoprostone	70-74	interleukin 1 beta	Homo sapiens	49-58
8218931-5	1993	IL-1 beta but not EGF stimulated the release of 3H-arachidonic acid (3H-AA) from prelabelled gingival fibroblasts.	3h-arachidonic acid	48-67	interleukin 1 beta	Homo sapiens	0-9
8218931-5	1993	IL-1 beta but not EGF stimulated the release of 3H-arachidonic acid (3H-AA) from prelabelled gingival fibroblasts.	3h-aa	69-74	interleukin 1 beta	Homo sapiens	0-9
8218931-8	1993	The results demonstrate that EGF and IL-1 as well as EGF and TNF-alpha act in concert to enhance prostanoid formation in gingival fibroblasts.	Prostaglandins	97-107	interleukin 1 beta	Homo sapiens	37-41
8218931-9	1993	Data indicates that EGF potentiates the IL-1 and TNF-alpha induced PGE2 formation at the level of prostaglandin endoperoxide synthase (cyclooxygenase).	Dinoprostone	67-71	interleukin 1 beta	Homo sapiens	40-44
8473757-6	1993	Chrysotile, crocidolite, amosite asbestos, and silica stimulated IL-1 beta and TNF-alpha release and up-regulated their respective mRNA in macrophages or monocytes.	Silicon Dioxide	47-53	interleukin 1 beta	Homo sapiens	65-74
8385577-8	1993	[3H]thymidine incorporation by normal or malignant ovarian epithelial cells was stimulated by a 24-h incubation with IL-1 beta or TNF-alpha.	[3h]thymidine	0-13	interleukin 1 beta	Homo sapiens	117-126
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	dibutyryl	62-71	interleukin 1 beta	Homo sapiens	168-186
7683563-11	1993	Simultaneous addition of dexamethasone (0.01-1 microM) or cycloheximide (0.03-3 microM) inhibited in a concentration-dependent manner TNF alpha- and IL-1 beta-induced expression of Ca(2+)-independent NO synthase activity.	Dexamethasone	25-38	interleukin 1 beta	Homo sapiens	149-158
7683563-11	1993	Simultaneous addition of dexamethasone (0.01-1 microM) or cycloheximide (0.03-3 microM) inhibited in a concentration-dependent manner TNF alpha- and IL-1 beta-induced expression of Ca(2+)-independent NO synthase activity.	Cycloheximide	58-71	interleukin 1 beta	Homo sapiens	149-158
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	dibutyryl	62-71	interleukin 1 beta	Homo sapiens	187-196
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Bucladesine	78-85	interleukin 1 beta	Homo sapiens	168-186
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Bucladesine	78-85	interleukin 1 beta	Homo sapiens	187-196
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	interleukin 1 beta	Homo sapiens	168-186
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	interleukin 1 beta	Homo sapiens	187-196
8340234-7	1993	The role of PKC on HLA-DR-mediated IL-1 beta induction was further confirmed by the ability of SEB to activate PKC on monocytes directly when measured with labeled phorbol ester ([3H]Pbt2)-binding capacity of whole cells.	Phorbol Esters	164-177	interleukin 1 beta	Homo sapiens	35-44
8340234-7	1993	The role of PKC on HLA-DR-mediated IL-1 beta induction was further confirmed by the ability of SEB to activate PKC on monocytes directly when measured with labeled phorbol ester ([3H]Pbt2)-binding capacity of whole cells.	Tritium	180-182	interleukin 1 beta	Homo sapiens	35-44
8340234-7	1993	The role of PKC on HLA-DR-mediated IL-1 beta induction was further confirmed by the ability of SEB to activate PKC on monocytes directly when measured with labeled phorbol ester ([3H]Pbt2)-binding capacity of whole cells.	PBT-1033	183-187	interleukin 1 beta	Homo sapiens	35-44
8340234-9	1993	Two tyrosine kinase inhibitors, genistein and dihydroxycinnamate, both inhibited SEB-induced IL-1 beta mRNA in monocytes.	Genistein	32-41	interleukin 1 beta	Homo sapiens	93-102
8340234-9	1993	Two tyrosine kinase inhibitors, genistein and dihydroxycinnamate, both inhibited SEB-induced IL-1 beta mRNA in monocytes.	dihydroxycinnamate	46-64	interleukin 1 beta	Homo sapiens	93-102
8386101-7	1993	In fact, interleukin-1 beta significantly inhibited the synthesis of prostaglandin E2 in iris-ciliary body.	Dinoprostone	69-85	interleukin 1 beta	Homo sapiens	9-27
8457602-11	1993	IL-1 receptor antagonist (IL-1ra) inhibited the stimulation of amnion cell PGE2 production by IL-1 beta, but not by TNF-alpha.	Dinoprostone	75-79	interleukin 1 beta	Homo sapiens	94-103
7680648-5	1993	Preincubation of the cells with cycloheximide "superinduced" the level of IL-8 mRNA stimulated by TNF alpha and IL-1 beta and RANTES mRNA stimulated by IL-1 beta, but decreased the expression of RANTES mRNA in response to TNF alpha.	Cycloheximide	32-45	interleukin 1 beta	Homo sapiens	112-121
7680648-5	1993	Preincubation of the cells with cycloheximide "superinduced" the level of IL-8 mRNA stimulated by TNF alpha and IL-1 beta and RANTES mRNA stimulated by IL-1 beta, but decreased the expression of RANTES mRNA in response to TNF alpha.	Cycloheximide	32-45	interleukin 1 beta	Homo sapiens	152-161
8454038-1	1993	The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated.	Phorbol Esters	109-123	interleukin 1 beta	Homo sapiens	58-76
8454038-1	1993	The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated.	Phorbol Esters	109-123	interleukin 1 beta	Homo sapiens	78-87
8454038-1	1993	The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated.	Tetradecanoylphorbol Acetate	125-128	interleukin 1 beta	Homo sapiens	58-76
8454038-1	1993	The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated.	Tetradecanoylphorbol Acetate	125-128	interleukin 1 beta	Homo sapiens	78-87
8454038-2	1993	Genistein, a specific tyrosine kinase inhibitor, inhibited PMA induced IL-1 beta protein and mRNA levels in THP-1 cells.	Genistein	0-9	interleukin 1 beta	Homo sapiens	71-80
8480469-7	1993	The Ca2+ entry blocker, verapamil, inhibited both the proliferative responses of thyrocytes to endothelin and the additive effect of endothelin and recombinant interleukin 1 beta on thyrocyte proliferation.	Verapamil	24-33	interleukin 1 beta	Homo sapiens	160-178
8156173-2	1993	Exposure to beta-naphthoflavone and benz(a)anthracene resulted in a higher copy number of IL-1 alpha and IL-6 mRNA while lower level of IL-1 beta mRNA was detected in these cells.	beta-Naphthoflavone	12-31	interleukin 1 beta	Homo sapiens	136-145
8156173-2	1993	Exposure to beta-naphthoflavone and benz(a)anthracene resulted in a higher copy number of IL-1 alpha and IL-6 mRNA while lower level of IL-1 beta mRNA was detected in these cells.	benz(a)anthracene	36-53	interleukin 1 beta	Homo sapiens	136-145
8099204-0	1993	Human astrocyte production of tumour necrosis factor-alpha, interleukin-1 beta, and interleukin-6 following exposure to lipopolysaccharide endotoxin.	lipopolysaccharide endotoxin	120-148	interleukin 1 beta	Homo sapiens	60-78
7681061-6	1993	Phorbol esters induced IL-1 mRNA, suggesting that activation of protein kinase C was responsible for the accumulation of this mRNA.	Phorbol Esters	0-14	interleukin 1 beta	Homo sapiens	23-27
7681061-7	1993	This hypothesis was confirmed by experiments with the PKC inhibitors staurosporine and calphostin C, which prevented the induction of IL-1 mRNA by TNF and accelerated the decay of this mRNA in cells pretreated with TNF.	Staurosporine	69-82	interleukin 1 beta	Homo sapiens	134-138
7681061-7	1993	This hypothesis was confirmed by experiments with the PKC inhibitors staurosporine and calphostin C, which prevented the induction of IL-1 mRNA by TNF and accelerated the decay of this mRNA in cells pretreated with TNF.	calphostin C	87-99	interleukin 1 beta	Homo sapiens	134-138
8461008-1	1993	We examined the effects of human recombinant IL-1 beta on glycogen metabolism in cultured rat hepatocytes.	Glycogen	58-66	interleukin 1 beta	Homo sapiens	45-54
8383677-2	1993	In human monocytes, the inhibitors of these phosphatases, okadaic acid and calyculin A, were found to increase the mRNA accumulation and cytokine production of interleukin-1 beta and interleukin-1 alpha.	Okadaic Acid	58-70	interleukin 1 beta	Homo sapiens	160-178
8383677-2	1993	In human monocytes, the inhibitors of these phosphatases, okadaic acid and calyculin A, were found to increase the mRNA accumulation and cytokine production of interleukin-1 beta and interleukin-1 alpha.	calyculin A	75-86	interleukin 1 beta	Homo sapiens	160-178
8383677-5	1993	Okadaic acid increased the synthesis of the interleukin-1 beta precursor and mature forms and their secretion.	Okadaic Acid	0-12	interleukin 1 beta	Homo sapiens	44-62
8498896-7	1993	Furthermore, in the culture supernatant the concentration of Leu-enk was positively correlated with that of IL-1 beta (r = 0.789).	Leucine	61-64	interleukin 1 beta	Homo sapiens	108-117
8156173-1	1993	Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied.	Polycyclic Aromatic Hydrocarbons	110-114	interleukin 1 beta	Homo sapiens	131-140
8436909-5	1993	PMA-treated, but not untreated cells, displayed an additional peptide derived from interleukin 1 beta.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	83-101
8509747-10	1993	Taken together, these data demonstrate that most bone-resorbing activity present in chronic human periapical lesions is attributable to the action of resorptive cytokines interleukin 1 beta and tumor necrosis factor beta, acting via both indomethacin-dependent and independent pathways.	Indomethacin	238-250	interleukin 1 beta	Homo sapiens	171-220
8455371-8	1993	This study demonstrates that during HD with regenerated cellulose, gene expression for IL-1 beta takes place in PBMC.	Cellulose	56-65	interleukin 1 beta	Homo sapiens	87-96
8441379-7	1993	When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 beta	Homo sapiens	56-68
8441379-7	1993	When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 beta	Homo sapiens	174-186
8383325-2	1993	In this report we demonstrate that the cytokine combination of human recombinant interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) induces the formation of nitric oxide by human islets.	Nitric Oxide	212-224	interleukin 1 beta	Homo sapiens	81-99
8383325-2	1993	In this report we demonstrate that the cytokine combination of human recombinant interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) induces the formation of nitric oxide by human islets.	Nitric Oxide	212-224	interleukin 1 beta	Homo sapiens	101-110
8383325-5	1993	IL-1 beta and IFN-gamma are sufficient to induce nitric oxide formation by human islets, whereas TNF-alpha potentiates nitrite production.	Nitric Oxide	49-61	interleukin 1 beta	Homo sapiens	0-9
8383325-8	1993	Higher concentrations (IL-1 beta at 75 units/ml, 3.5 nM TNF-alpha, and IFN-gamma at 750 units/ml) inhibit insulin secretion from human islets, and the inhibitory effect is prevented by NG-monomethyl-L-arginine.	omega-N-Methylarginine	185-209	interleukin 1 beta	Homo sapiens	23-32
8450021-6	1993	This method was also used in the large-scale separation of N-Met from des-Met recombinant human interleukin-1 beta.	n-met	59-64	interleukin 1 beta	Homo sapiens	96-114
8387070-9	1993	The in vitro production of interleukin-1 beta and IL-2 in supernatants obtained after stimulation of BMNC with phytohemagglutinin or lipopolysaccharide was not affected.	bmnc	101-105	interleukin 1 beta	Homo sapiens	27-45
8501138-5	1993	Similarly, IL-1 treatment resulted in a beta 2 integrin mediated increase in neutrophil adherence to the DMJ treated endothelial cells in a dose dependent manner.	1-Deoxynojirimycin	105-108	interleukin 1 beta	Homo sapiens	11-15
7679081-3	1993	Moreover, the stimulatory effects of recombinant IL-1 beta on NOS mRNA expression are prevented by co-incubation with an inhibitor of gene transcription (actinomycin D) or an inhibitor of protein synthesis (cycloheximide).	Dactinomycin	154-167	interleukin 1 beta	Homo sapiens	49-58
7679081-3	1993	Moreover, the stimulatory effects of recombinant IL-1 beta on NOS mRNA expression are prevented by co-incubation with an inhibitor of gene transcription (actinomycin D) or an inhibitor of protein synthesis (cycloheximide).	Cycloheximide	207-220	interleukin 1 beta	Homo sapiens	49-58
8450021-6	1993	This method was also used in the large-scale separation of N-Met from des-Met recombinant human interleukin-1 beta.	Diethylstilbestrol	70-73	interleukin 1 beta	Homo sapiens	96-114
8427707-0	1993	Regulation of interleukin-1ra, interleukin-1 alpha, and interleukin-1 beta production by human alveolar macrophages with phorbol myristate acetate, lipopolysaccharide, and interleukin-4.	Tetradecanoylphorbol Acetate	121-146	interleukin 1 beta	Homo sapiens	56-74
8447474-0	1993	Plasmin potentiates induction of nitric oxide synthesis by interleukin-1 beta in vascular smooth muscle cells.	Nitric Oxide	33-45	interleukin 1 beta	Homo sapiens	59-77
8447474-1	1993	Experiments were performed to examine the effect of the major fibrinolytic protease, plasmin, on the production of nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured human and rat aortic smooth muscle cells.	Nitric Oxide	115-127	interleukin 1 beta	Homo sapiens	133-151
8447474-1	1993	Experiments were performed to examine the effect of the major fibrinolytic protease, plasmin, on the production of nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured human and rat aortic smooth muscle cells.	Nitric Oxide	115-127	interleukin 1 beta	Homo sapiens	153-162
8447474-2	1993	Incubation of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite and nitrate in the culture media.	Nitrites	98-105	interleukin 1 beta	Homo sapiens	48-57
8447474-2	1993	Incubation of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite and nitrate in the culture media.	Nitrates	110-117	interleukin 1 beta	Homo sapiens	48-57
8447474-3	1993	Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta.	Nitrites	159-166	interleukin 1 beta	Homo sapiens	129-138
8447474-3	1993	Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta.	Nitrates	171-178	interleukin 1 beta	Homo sapiens	129-138
8447474-3	1993	Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta.	Nitrites	277-284	interleukin 1 beta	Homo sapiens	129-138
8447474-3	1993	Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta.	Nitrates	289-296	interleukin 1 beta	Homo sapiens	129-138
8447474-5	1993	The perfusates from columns containing IL-1 beta-treated smooth muscle cells relaxed detector blood vessels without endothelium, and the addition of IL-1 beta-treated smooth muscle cells to suspensions of indomethacin-treated platelets inhibited their aggregation.	Indomethacin	205-217	interleukin 1 beta	Homo sapiens	149-158
8447474-9	1993	These results demonstrate that the plasmin can enhance the production of nitric oxide by IL-1 beta-treated vascular smooth muscle cells.	Nitric Oxide	73-85	interleukin 1 beta	Homo sapiens	89-98
8427707-2	1993	We have previously shown that AM produce a specific interleukin-1 (IL-1) inhibitor of 20 to 25 kD that blocks biologic activities of IL-1 alpha and IL-1 beta such as prostaglandin E2 production by fibroblasts.	Dinoprostone	166-182	interleukin 1 beta	Homo sapiens	148-157
8043803-2	1993	In mice recombinant human IL-1 beta dose-dependently induces high level serum corticosterone.	Corticosterone	78-92	interleukin 1 beta	Homo sapiens	26-35
8431204-6	1993	RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls.	Phosphatidylcholines	88-107	interleukin 1 beta	Homo sapiens	56-65
8431204-6	1993	RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls.	Phosphatidylcholines	109-111	interleukin 1 beta	Homo sapiens	56-65
8431204-6	1993	RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls.	Phosphatidylinositols	114-134	interleukin 1 beta	Homo sapiens	56-65
8431204-6	1993	RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls.	phosphatidylethanolamine	145-169	interleukin 1 beta	Homo sapiens	56-65
8431204-6	1993	RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls.	phosphatidylethanolamine	171-173	interleukin 1 beta	Homo sapiens	56-65
8425476-3	1993	When freshly isolated cytotrophoblasts were incubated in medium supplemented with androstenedione, treatment with human IL-1 beta (hIL-1 beta) consistently increased the aromatization of this androgen to estrogens.	Androstenedione	82-97	interleukin 1 beta	Homo sapiens	120-129
8381442-1	1993	We have investigated the effect of (a) stress and (b) steroid feed-back on the interleukin-1 beta (IL-1 beta)-mediated increase of corticotropin-releasing factor (CRF) mRNA in the hypothalamic paraventricular nucleus.	Steroids	54-61	interleukin 1 beta	Homo sapiens	79-97
8381442-1	1993	We have investigated the effect of (a) stress and (b) steroid feed-back on the interleukin-1 beta (IL-1 beta)-mediated increase of corticotropin-releasing factor (CRF) mRNA in the hypothalamic paraventricular nucleus.	Steroids	54-61	interleukin 1 beta	Homo sapiens	99-108
8437102-5	1993	Ethoxyresorufin-O-deethylation was depressed 6-fold in arthritic rat liver microsomes and the highest dosage of IL-1 potentiated this depression.	ethoxyresorufin	0-15	interleukin 1 beta	Homo sapiens	112-116
8437102-6	1993	Pentoxyresorufin-O-deethylation decreased by 50% in arthritic rat, a dose-dependent decrease being observed after IL-1 treatment.	pentoxyresorufin-o	0-18	interleukin 1 beta	Homo sapiens	114-118
8437102-7	1993	Progesterone 6 beta-hydroxylation and P-450 IIIA protein increased by 2-fold in both untreated arthritic rat liver microsomes and those treated by the lowest dose of IL-1.	Progesterone	0-12	interleukin 1 beta	Homo sapiens	166-170
8437102-9	1993	Lauric acid hydroxylation increased 2-fold in arthritic rat and was further potentiated by IL-1.	lauric acid	0-11	interleukin 1 beta	Homo sapiens	91-95
7682199-1	1993	Compounds from two distinct pharmacological classes namely, SK&amp;F 86002 and pentoxifylline, were examined for their effects on TNF alpha and IL-1 beta release by human monocytes stimulated with LPS or monoclonal antibodies to three cell surface glycoproteins, CD44, CD45 and LFA-3 (LFA-3 is also known as CD58).	amicloral	60-66	interleukin 1 beta	Homo sapiens	144-153
7682199-1	1993	Compounds from two distinct pharmacological classes namely, SK&amp;F 86002 and pentoxifylline, were examined for their effects on TNF alpha and IL-1 beta release by human monocytes stimulated with LPS or monoclonal antibodies to three cell surface glycoproteins, CD44, CD45 and LFA-3 (LFA-3 is also known as CD58).	Pentoxifylline	79-93	interleukin 1 beta	Homo sapiens	144-153
7682199-2	1993	SK&amp;F 86002, an inhibitor of 5-LO and CO in arachidonic acid metabolism, inhibited LPS-induced release of TNF alpha and IL-1 beta with an IC50 of 1 microM.	amicloral	0-6	interleukin 1 beta	Homo sapiens	123-132
7682199-5	1993	TNF alpha and IL-1 beta release mediated by the monoclonal antibodies were inhibited by less than 30% in the presence of 100 microM pentoxifylline.	Pentoxifylline	132-146	interleukin 1 beta	Homo sapiens	14-23
7682199-6	1993	These results suggest that (a) LPS induced cytokine release shares a common step with the physiologically relevant stimuli (involving cross-linking of cell surface receptors), and that this pathway is sensitive to inhibition by SK&amp;F 86002 and, (b) SK&amp;F 86002 is more potent than pentoxifylline in inhibiting TNF alpha and IL-1 beta release induced by both stimuli.	amicloral	228-234	interleukin 1 beta	Homo sapiens	330-339
7682199-6	1993	These results suggest that (a) LPS induced cytokine release shares a common step with the physiologically relevant stimuli (involving cross-linking of cell surface receptors), and that this pathway is sensitive to inhibition by SK&amp;F 86002 and, (b) SK&amp;F 86002 is more potent than pentoxifylline in inhibiting TNF alpha and IL-1 beta release induced by both stimuli.	amicloral	252-258	interleukin 1 beta	Homo sapiens	330-339
8381442-3	1993	The effect of IL-1 beta was blunted by adrenalectomy, but returned when a replacement dose of dexamethasone was administered.	Dexamethasone	94-107	interleukin 1 beta	Homo sapiens	14-23
8425476-3	1993	When freshly isolated cytotrophoblasts were incubated in medium supplemented with androstenedione, treatment with human IL-1 beta (hIL-1 beta) consistently increased the aromatization of this androgen to estrogens.	Androstenedione	82-97	interleukin 1 beta	Homo sapiens	131-141
8425476-5	1993	This was indeed due to increased hIL-1 beta-mediated estrogen biosynthesis, rather than to decreased catabolism of estrogens, since cytotrophoblasts incubated in the presence of hIL-1 beta for 24 h exhibited 65% greater aromatase activity than control cells (P &lt; 0.0001), as quantitated by the specific release of 3H2O from [3H] androstenedione.	3h2o	317-321	interleukin 1 beta	Homo sapiens	178-188
8429822-2	1993	Dexamethasone (DEX) decreased levels of IL-1 alpha and IL-1 beta mRNAs in a dose-related fashion.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	55-64
8425476-5	1993	This was indeed due to increased hIL-1 beta-mediated estrogen biosynthesis, rather than to decreased catabolism of estrogens, since cytotrophoblasts incubated in the presence of hIL-1 beta for 24 h exhibited 65% greater aromatase activity than control cells (P &lt; 0.0001), as quantitated by the specific release of 3H2O from [3H] androstenedione.	Tritium	317-319	interleukin 1 beta	Homo sapiens	178-188
8429822-2	1993	Dexamethasone (DEX) decreased levels of IL-1 alpha and IL-1 beta mRNAs in a dose-related fashion.	Dexamethasone	15-18	interleukin 1 beta	Homo sapiens	55-64
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	79-104	interleukin 1 beta	Homo sapiens	150-168
8425476-5	1993	This was indeed due to increased hIL-1 beta-mediated estrogen biosynthesis, rather than to decreased catabolism of estrogens, since cytotrophoblasts incubated in the presence of hIL-1 beta for 24 h exhibited 65% greater aromatase activity than control cells (P &lt; 0.0001), as quantitated by the specific release of 3H2O from [3H] androstenedione.	Androstenedione	332-347	interleukin 1 beta	Homo sapiens	178-188
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	79-104	interleukin 1 beta	Homo sapiens	170-179
8429822-3	1993	The DEX-induced decrease in levels of IL-1 alpha and IL-1 beta mRNAs was abolished by the steroid receptor antagonist RU486.	Dexamethasone	4-7	interleukin 1 beta	Homo sapiens	53-62
8429822-3	1993	The DEX-induced decrease in levels of IL-1 alpha and IL-1 beta mRNAs was abolished by the steroid receptor antagonist RU486.	Mifepristone	118-123	interleukin 1 beta	Homo sapiens	53-62
8425476-7	1993	In time-course studies, significant stimulation of the conversion of androstenedione to estrogens by hIL-1 beta could be detected as early as after 4 h of treatment and persisted for at least 24 h. Human IL-1 alpha stimulated the conversion of androstenedione to estrogens to an extent similar to that of hIL-1 beta, whereas the effects of murine IL-1 beta on aromatase activity were inconsistent.	Androstenedione	69-84	interleukin 1 beta	Homo sapiens	101-111
8429822-4	1993	The levels of IL-1 alpha and IL-1 beta proteins within the cells and of IL-1 beta in the culture medium were decreased by DEX to comparable extents, so that DEX had no detectable effect on cytokine secretion.	Dexamethasone	122-125	interleukin 1 beta	Homo sapiens	29-38
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	106-109	interleukin 1 beta	Homo sapiens	150-168
8425476-7	1993	In time-course studies, significant stimulation of the conversion of androstenedione to estrogens by hIL-1 beta could be detected as early as after 4 h of treatment and persisted for at least 24 h. Human IL-1 alpha stimulated the conversion of androstenedione to estrogens to an extent similar to that of hIL-1 beta, whereas the effects of murine IL-1 beta on aromatase activity were inconsistent.	Androstenedione	69-84	interleukin 1 beta	Homo sapiens	305-315
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	106-109	interleukin 1 beta	Homo sapiens	170-179
8429822-4	1993	The levels of IL-1 alpha and IL-1 beta proteins within the cells and of IL-1 beta in the culture medium were decreased by DEX to comparable extents, so that DEX had no detectable effect on cytokine secretion.	Dexamethasone	122-125	interleukin 1 beta	Homo sapiens	72-81
8429822-6	1993	However, DEX markedly decreased the stability of IL-1 beta mRNA, as shown both by steady state measurements and by pulse-labeling.	Dexamethasone	9-12	interleukin 1 beta	Homo sapiens	49-58
8425476-7	1993	In time-course studies, significant stimulation of the conversion of androstenedione to estrogens by hIL-1 beta could be detected as early as after 4 h of treatment and persisted for at least 24 h. Human IL-1 alpha stimulated the conversion of androstenedione to estrogens to an extent similar to that of hIL-1 beta, whereas the effects of murine IL-1 beta on aromatase activity were inconsistent.	Androstenedione	244-259	interleukin 1 beta	Homo sapiens	101-111
8429822-7	1993	DEX-induced instability of IL-1 beta mRNA required protein synthesis.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	27-36
8457632-6	1993	Challenge with PMA induced low levels of IL-1 beta production with a relatively large percentage released.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 beta	Homo sapiens	41-50
8429822-8	1993	DEX was also found to be a potent inhibitor of IL-1-induced expression of the IL-6 gene in connective tissue-type cells from the synovium of patients with rheumatoid arthritis.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	47-51
8425476-7	1993	In time-course studies, significant stimulation of the conversion of androstenedione to estrogens by hIL-1 beta could be detected as early as after 4 h of treatment and persisted for at least 24 h. Human IL-1 alpha stimulated the conversion of androstenedione to estrogens to an extent similar to that of hIL-1 beta, whereas the effects of murine IL-1 beta on aromatase activity were inconsistent.	Androstenedione	244-259	interleukin 1 beta	Homo sapiens	305-315
7680174-0	1993	IL-1 beta-induced inhibition of beta-cell function is mediated through nitric oxide.	Nitric Oxide	71-83	interleukin 1 beta	Homo sapiens	0-9
8515598-1	1993	In order to investigate the role of interleukin-1 beta secreted by alveolar macrophages in the pathogenesis of pulmonary asbestosis, we performed bronchoalveolar lavage on 12 asbestos-exposed subjects and 10 control subjects, and measured interleukin-1 beta secreted by alveolar macrophages.	Asbestos	121-129	interleukin 1 beta	Homo sapiens	36-54
8515598-2	1993	Interleukin-1 beta production was increased in the asbestos-exposed subjects compared to control subjects (3.1 +/- 2.2 ng/ml versus 0.8 +/- 0.4 ng/ml, p &lt; 0.05).	Asbestos	51-59	interleukin 1 beta	Homo sapiens	0-18
8416817-0	1993	Continuous presence of phorbol ester is required for its IL-1 beta mRNA stabilizing effect.	Phorbol Esters	23-36	interleukin 1 beta	Homo sapiens	57-66
8422241-2	1993	The minimal IL-1 beta concentrations for stimulation of IL-6 and PGE2 production by SSc fibroblasts were 10-fold and 100-fold lower, respectively, than those for normal fibroblasts.	Dinoprostone	65-69	interleukin 1 beta	Homo sapiens	12-21
8512018-7	1993	After treatment with PMA and LPS, IL-1 alpha was detected in the culture fluid from two other lines and IL-1 beta in the medium from three lines.	Tetradecanoylphorbol Acetate	21-24	interleukin 1 beta	Homo sapiens	104-113
8424804-0	1993	Influence of human recombinant interleukin-1 beta on the enantioselective disposition of propranolol in rats.	Propranolol	89-100	interleukin 1 beta	Homo sapiens	31-49
8424804-2	1993	administration of 10 micrograms/kg recombinant human interleukin-1 beta (rhIL-1 beta), a putative mediator of inflammation, on the pharmacokinetics and metabolism of the propranolol enantiomers was studied in rats aged 3, 12 and 24 months.	Propranolol	170-181	interleukin 1 beta	Homo sapiens	53-71
7506004-3	1993	In this study we investigated whether the novel anti-inflammatory drug, SK&amp;F 86002 [5-4(-pyridyl)-6(4-fluorophenyl)-2,3-dihydroimidazole(2,1-b)thi azol] and related analogs of the pyridinyl imidazole class, inhibit IL-1 and TNF production via a cAMP-dependent mechanism.	Adenosine Monophosphate	75-78	interleukin 1 beta	Homo sapiens	219-223
7506004-0	1993	Inhibition of interleukin-1 (IL-1) and tumor necrosis factor (TNF) production by pyridinyl imidazole compounds is independent of cAMP elevating mechanisms.	2-(1H-imidazol-2-yl)pyridine	81-100	interleukin 1 beta	Homo sapiens	29-33
7506004-3	1993	In this study we investigated whether the novel anti-inflammatory drug, SK&amp;F 86002 [5-4(-pyridyl)-6(4-fluorophenyl)-2,3-dihydroimidazole(2,1-b)thi azol] and related analogs of the pyridinyl imidazole class, inhibit IL-1 and TNF production via a cAMP-dependent mechanism.	5-4(-pyridyl)-6(4-fluorophenyl)-2,3-dihydroimidazole	88-140	interleukin 1 beta	Homo sapiens	219-223
7506004-6	1993	In contrast, PGE2, which significantly elevated intracellular cAMP levels, inhibited TNF but not IL-1 production at the transcriptional level.	Dinoprostone	13-17	interleukin 1 beta	Homo sapiens	97-101
7506004-7	1993	Taken together, these results suggest that the pyridinyl imidazoles inhibit the production of IL-1 beta and TNF alpha through pathways independent of cAMP elevating mechanisms.	pyridinyl imidazoles	47-67	interleukin 1 beta	Homo sapiens	94-103
8273584-0	1993	Interleukin-1 beta induces cytosolic PLA2 in parallel with prostaglandin E2 in rheumatoid synovial fibroblasts.	Dinoprostone	59-75	interleukin 1 beta	Homo sapiens	0-18
8273589-0	1993	Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level.	pyridinyl imidazoles	0-20	interleukin 1 beta	Homo sapiens	29-33
8273591-7	1993	It is proposed that a novel protein kinase susceptible to geldanamycin inhibition may be involved in IL-1-mediated signal transduction.	geldanamycin	58-70	interleukin 1 beta	Homo sapiens	101-105
8273589-1	1993	The mechanism by which SK&amp;F 86002 and other pyridinyl imidazoles inhibit the production of IL-1 and TNF from LPS-stimulated human monocytes was examined.	amicloral	23-29	interleukin 1 beta	Homo sapiens	95-99
8273589-1	1993	The mechanism by which SK&amp;F 86002 and other pyridinyl imidazoles inhibit the production of IL-1 and TNF from LPS-stimulated human monocytes was examined.	pyridinyl imidazoles	48-68	interleukin 1 beta	Homo sapiens	95-99
8273589-2	1993	Inhibition of IL-1 and TNF production was found to depend on the time of addition of SK&amp;F 86002, with diminishing effect when added more than 2 h after LPS stimulation.	amicloral	85-91	interleukin 1 beta	Homo sapiens	14-26
8273589-3	1993	Analysis of Western blots confirmed that both intracellular IL-1 beta and extracellular TNF were significantly reduced in response to SK&amp;F 86002, but these reductions were not paralleled by changes in IL-1 and TNF mRNA.	amicloral	134-140	interleukin 1 beta	Homo sapiens	60-69
8273589-3	1993	Analysis of Western blots confirmed that both intracellular IL-1 beta and extracellular TNF were significantly reduced in response to SK&amp;F 86002, but these reductions were not paralleled by changes in IL-1 and TNF mRNA.	amicloral	134-140	interleukin 1 beta	Homo sapiens	60-64
8273584-4	1993	These findings support that an augmentation of CPLA2 activity, caused by an induction of cPLA2 protein, rather than sPLA2, is temporally associated with increased PGE2 production in IL-1 beta-treated RSF.	Dinoprostone	163-167	interleukin 1 beta	Homo sapiens	182-191
8273584-4	1993	These findings support that an augmentation of CPLA2 activity, caused by an induction of cPLA2 protein, rather than sPLA2, is temporally associated with increased PGE2 production in IL-1 beta-treated RSF.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	200-203	interleukin 1 beta	Homo sapiens	182-191
8273589-4	1993	35S methionine pulse and pulse-chase studies on IL-1 biosynthesis suggest that significant inhibition by SK&amp;F 86002 and related compounds occurs at the translational level.	Sulfur-35	0-3	interleukin 1 beta	Homo sapiens	48-52
8273592-5	1993	Zaprinast stimulated IL-1 beta and to a lesser extent TNF alpha production.	zaprinast	0-9	interleukin 1 beta	Homo sapiens	21-30
8273589-4	1993	35S methionine pulse and pulse-chase studies on IL-1 biosynthesis suggest that significant inhibition by SK&amp;F 86002 and related compounds occurs at the translational level.	Methionine	4-14	interleukin 1 beta	Homo sapiens	48-52
8273589-4	1993	35S methionine pulse and pulse-chase studies on IL-1 biosynthesis suggest that significant inhibition by SK&amp;F 86002 and related compounds occurs at the translational level.	amicloral	105-111	interleukin 1 beta	Homo sapiens	48-52
8456629-6	1993	In the absence of LPS and at therapeutic concentration, tiaprofenic acid decreased both the synthesis and release of IL-1 beta.	tiaprofenic acid	56-72	interleukin 1 beta	Homo sapiens	117-126
8480532-1	1993	Effects of hyaluronan (HA) on the prostaglandin E2 (PGE2) production induced by recombinant human interleukin-1 beta (rhIL-1 beta) in rabbit articular chondrocytes were studied in vitro.	Hyaluronic Acid	23-25	interleukin 1 beta	Homo sapiens	98-116
8456629-9	1993	As expected, hydrocortisone demonstrated a marked decrease on IL-1 alpha and IL-1 beta, both in the presence and absence of LPS.	Hydrocortisone	13-27	interleukin 1 beta	Homo sapiens	77-86
8273590-3	1993	As previously reported, the 5-lipoxygenase/cyclooxygenase (5-LO/CO) inhibitor, SKF86002 (30 microM), significantly inhibited both IL-1 beta and TNF-alpha release using either stimulus.	6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole	79-87	interleukin 1 beta	Homo sapiens	130-139
8273590-5	1993	Isoproterenol (beta-agonist), rolipram (a PDE-IV inhibitor), and IBMX (a nonselective PDE inhibitor), significantly inhibited TNF-alpha but not IL-1 beta in the LPS model while having no effect in the zymosan model.	Isoproterenol	0-13	interleukin 1 beta	Homo sapiens	144-153
8273590-5	1993	Isoproterenol (beta-agonist), rolipram (a PDE-IV inhibitor), and IBMX (a nonselective PDE inhibitor), significantly inhibited TNF-alpha but not IL-1 beta in the LPS model while having no effect in the zymosan model.	Rolipram	30-38	interleukin 1 beta	Homo sapiens	144-153
8273590-5	1993	Isoproterenol (beta-agonist), rolipram (a PDE-IV inhibitor), and IBMX (a nonselective PDE inhibitor), significantly inhibited TNF-alpha but not IL-1 beta in the LPS model while having no effect in the zymosan model.	1-Methyl-3-isobutylxanthine	65-69	interleukin 1 beta	Homo sapiens	144-153
8480532-1	1993	Effects of hyaluronan (HA) on the prostaglandin E2 (PGE2) production induced by recombinant human interleukin-1 beta (rhIL-1 beta) in rabbit articular chondrocytes were studied in vitro.	Dinoprostone	34-50	interleukin 1 beta	Homo sapiens	98-116
8480532-1	1993	Effects of hyaluronan (HA) on the prostaglandin E2 (PGE2) production induced by recombinant human interleukin-1 beta (rhIL-1 beta) in rabbit articular chondrocytes were studied in vitro.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	98-116
8430802-1	1993	We examined the ability of human recombinant interleukin-1 beta (hrIL-1 beta) to alter the release of [3H]norepinephrine ([3H]NE) by KCl or electrical field stimulation in longitudinal muscle-myenteric plexus of rat intestine.	[3H]norepinephrine	102-120	interleukin 1 beta	Homo sapiens	45-63
8430802-1	1993	We examined the ability of human recombinant interleukin-1 beta (hrIL-1 beta) to alter the release of [3H]norepinephrine ([3H]NE) by KCl or electrical field stimulation in longitudinal muscle-myenteric plexus of rat intestine.	Tritium	103-105	interleukin 1 beta	Homo sapiens	45-63
8430802-1	1993	We examined the ability of human recombinant interleukin-1 beta (hrIL-1 beta) to alter the release of [3H]norepinephrine ([3H]NE) by KCl or electrical field stimulation in longitudinal muscle-myenteric plexus of rat intestine.	Potassium Chloride	133-136	interleukin 1 beta	Homo sapiens	45-63
8419137-6	1993	The addition of human recombinant IL-1 beta (4 ng/ml) induced ovulation (1.6 +/- 0.4) and increased the LH-induced ovulation rate 3-fold (9.8 +/- 0.5).	Luteinizing Hormone	104-106	interleukin 1 beta	Homo sapiens	34-43
8427512-3	1993	The loss of glycosaminoglycan by rat and human femoral head cartilage in response to human recombinant interleukin 1 beta (rhIL-1 beta) was established, and the modulation of this loss by the metalloproteinase inhibitor U27391 was investigated.	Glycosaminoglycans	12-29	interleukin 1 beta	Homo sapiens	103-121
7692996-0	1993	Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: prevention by dexamethasone.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	22-31
7692996-0	1993	Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: prevention by dexamethasone.	Dexamethasone	89-102	interleukin 1 beta	Homo sapiens	22-31
7692996-1	1993	Nitric oxide has recently been implicated as a cellular molecule that mediates interleukin-1 beta (IL-1 beta)-induced inhibition of glucose-stimulated insulin secretion by islets of Langerhans.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	79-97
7692996-1	1993	Nitric oxide has recently been implicated as a cellular molecule that mediates interleukin-1 beta (IL-1 beta)-induced inhibition of glucose-stimulated insulin secretion by islets of Langerhans.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	99-108
7692996-1	1993	Nitric oxide has recently been implicated as a cellular molecule that mediates interleukin-1 beta (IL-1 beta)-induced inhibition of glucose-stimulated insulin secretion by islets of Langerhans.	Glucose	132-139	interleukin 1 beta	Homo sapiens	79-97
7692996-1	1993	Nitric oxide has recently been implicated as a cellular molecule that mediates interleukin-1 beta (IL-1 beta)-induced inhibition of glucose-stimulated insulin secretion by islets of Langerhans.	Glucose	132-139	interleukin 1 beta	Homo sapiens	99-108
7692996-4	1993	Both control and IL-1 beta-induced NADPH diaphorase staining of islets is inhibited by the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (NMMA).	omega-N-Methylarginine	123-147	interleukin 1 beta	Homo sapiens	17-26
7692996-4	1993	Both control and IL-1 beta-induced NADPH diaphorase staining of islets is inhibited by the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (NMMA).	omega-N-Methylarginine	149-153	interleukin 1 beta	Homo sapiens	17-26
7692996-7	1993	IL-1 beta is believed to stimulate the expression of cytokine inducible nitric oxide synthase because the synthetic glucocorticoid, dexamethasone, prevents IL-1 beta induced inhibition of glucose stimulated insulin secretion and cGMP accumulation by islets.	Dexamethasone	132-145	interleukin 1 beta	Homo sapiens	0-9
7692996-7	1993	IL-1 beta is believed to stimulate the expression of cytokine inducible nitric oxide synthase because the synthetic glucocorticoid, dexamethasone, prevents IL-1 beta induced inhibition of glucose stimulated insulin secretion and cGMP accumulation by islets.	Dexamethasone	132-145	interleukin 1 beta	Homo sapiens	156-165
7692996-7	1993	IL-1 beta is believed to stimulate the expression of cytokine inducible nitric oxide synthase because the synthetic glucocorticoid, dexamethasone, prevents IL-1 beta induced inhibition of glucose stimulated insulin secretion and cGMP accumulation by islets.	Glucose	188-195	interleukin 1 beta	Homo sapiens	0-9
7692996-7	1993	IL-1 beta is believed to stimulate the expression of cytokine inducible nitric oxide synthase because the synthetic glucocorticoid, dexamethasone, prevents IL-1 beta induced inhibition of glucose stimulated insulin secretion and cGMP accumulation by islets.	Glucose	188-195	interleukin 1 beta	Homo sapiens	156-165
7692996-7	1993	IL-1 beta is believed to stimulate the expression of cytokine inducible nitric oxide synthase because the synthetic glucocorticoid, dexamethasone, prevents IL-1 beta induced inhibition of glucose stimulated insulin secretion and cGMP accumulation by islets.	Cyclic GMP	229-233	interleukin 1 beta	Homo sapiens	0-9
7692996-7	1993	IL-1 beta is believed to stimulate the expression of cytokine inducible nitric oxide synthase because the synthetic glucocorticoid, dexamethasone, prevents IL-1 beta induced inhibition of glucose stimulated insulin secretion and cGMP accumulation by islets.	Cyclic GMP	229-233	interleukin 1 beta	Homo sapiens	156-165
7692996-8	1993	Both dexamethasone, and the nitric oxide synthase inhibitors NMMA and aminoguanidine also prevent IL-1 beta induced islet degeneration.	Dexamethasone	5-18	interleukin 1 beta	Homo sapiens	98-107
7692996-8	1993	Both dexamethasone, and the nitric oxide synthase inhibitors NMMA and aminoguanidine also prevent IL-1 beta induced islet degeneration.	omega-N-Methylarginine	61-65	interleukin 1 beta	Homo sapiens	98-107
7692996-8	1993	Both dexamethasone, and the nitric oxide synthase inhibitors NMMA and aminoguanidine also prevent IL-1 beta induced islet degeneration.	pimagedine	70-84	interleukin 1 beta	Homo sapiens	98-107
7679950-5	1993	The level of IL-6 activity in the CF and RF consistently increased; beginning 2 h after TNF alpha injection and reaching the maximum between 8 h and 12 h. It returned to the basal level within 48 h. IL-1 beta was detected in the CF of three patients, its level peaking at 8 h. Prostaglandin E2 also increased after injection of TNF alpha, peaking between 4 h and 12 h and then gradually decreasing.	Dinoprostone	277-293	interleukin 1 beta	Homo sapiens	199-208
8439987-4	1993	Generally, arabinogalactan pretreatment induced an increased release of interferon gamma (IFN gamma), tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta) and IL-6 but only IFN gamma was involved in enhancement of NK cytotoxicity since cytotoxicity enhancement of PBMC and PNAC but not that of monocytes could be blocked when anti-IFN gamma antibodies were present during pretreatment.	arabinogalactan	11-26	interleukin 1 beta	Homo sapiens	131-149
8439987-4	1993	Generally, arabinogalactan pretreatment induced an increased release of interferon gamma (IFN gamma), tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta) and IL-6 but only IFN gamma was involved in enhancement of NK cytotoxicity since cytotoxicity enhancement of PBMC and PNAC but not that of monocytes could be blocked when anti-IFN gamma antibodies were present during pretreatment.	arabinogalactan	11-26	interleukin 1 beta	Homo sapiens	151-160
8425226-8	1993	IL-1 beta, IL-2, and IFN-gamma, was also elevated in cDT-stimulated cultures; and (4) the enhanced proliferative response to cDT could be attributed to CD4+ helper T cells.	cdt	53-56	interleukin 1 beta	Homo sapiens	0-9
8419122-7	1993	Inhibition of LH-stimulated testosterone production was observed also when Leydig cells were cultured in the presence of testicular macrophages for 24 h before maximal LH stimulation (8 ng/ml) for a further 24 h. Human recombinant interleukin-1 alpha and interleukin-1 beta (0.5-10 U/ml) did not significantly alter basal or LH-stimulated Leydig cell testosterone production at 24, 48, or 72 h of culture.	Luteinizing Hormone	14-16	interleukin 1 beta	Homo sapiens	255-273
8476228-4	1993	On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1 beta production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1 beta induction.	Hydrolyzable Tannins	29-42	interleukin 1 beta	Homo sapiens	118-127
8476228-4	1993	On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1 beta production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1 beta induction.	Hydrolyzable Tannins	29-42	interleukin 1 beta	Homo sapiens	322-331
8476228-4	1993	On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1 beta production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1 beta induction.	rugosin A	77-86	interleukin 1 beta	Homo sapiens	118-127
8476228-4	1993	On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1 beta production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1 beta induction.	rugosin A	77-86	interleukin 1 beta	Homo sapiens	322-331
8476228-4	1993	On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1 beta production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1 beta induction.	casuarictin	91-102	interleukin 1 beta	Homo sapiens	118-127
8476228-4	1993	On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1 beta production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1 beta induction.	casuarictin	91-102	interleukin 1 beta	Homo sapiens	322-331
8490101-3	1993	Indeed, previous studies have shown that monocytes exposed to paraformaldehyde (PFA)-fixed, activated T cells produced high amounts of IL-1 beta.	paraform	62-78	interleukin 1 beta	Homo sapiens	135-144
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Alginates	134-142	interleukin 1 beta	Homo sapiens	0-9
8490101-3	1993	Indeed, previous studies have shown that monocytes exposed to paraformaldehyde (PFA)-fixed, activated T cells produced high amounts of IL-1 beta.	paraform	80-83	interleukin 1 beta	Homo sapiens	135-144
8490101-7	1993	De novo protein synthesis was required for the expression of the IL-1 beta inducing factor, as shown by cycloheximide treatment.	Cycloheximide	104-117	interleukin 1 beta	Homo sapiens	65-74
7803193-0	1993	A recombinant human interleukin-1 beta protects adriamycin-induced toxicity.	Doxorubicin	48-58	interleukin 1 beta	Homo sapiens	20-38
7803193-2	1993	Pretreatment with recombinant human interleukin-1 beta (IL-1) protected normal BALB/c mice from the lethal effect adriamycin (ADM) of related to dose and frequency of administration.	Doxorubicin	114-124	interleukin 1 beta	Homo sapiens	36-54
7803193-2	1993	Pretreatment with recombinant human interleukin-1 beta (IL-1) protected normal BALB/c mice from the lethal effect adriamycin (ADM) of related to dose and frequency of administration.	Doxorubicin	126-129	interleukin 1 beta	Homo sapiens	36-54
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Alginates	134-142	interleukin 1 beta	Homo sapiens	36-45
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Polylysine	143-153	interleukin 1 beta	Homo sapiens	0-9
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Polylysine	143-153	interleukin 1 beta	Homo sapiens	36-45
18475502-3	1993	Treatment of peripheral blood monocytes with 2 mug/ml lipopolysaccharide potently increased IL-1beta release (p = 0.001) and dexamethasone (10(-7) M) significantly reduced both resting and stimulated IL-1beta release (p = 0.009).	Dexamethasone	125-138	interleukin 1 beta	Homo sapiens	200-208
8144314-3	1993	Therefore, we investigated whether cyclic AMP, protein kinase A and NF kappa B are involved in the induction of IL-1 beta release by human peripheral blood monocyte-derived macrophages (HPBM) stimulated with a specific IL-1 beta inducer, 9-hydroxyoctadecadienoic acid (9-HODE).	Cyclic AMP	35-45	interleukin 1 beta	Homo sapiens	112-121
8144314-3	1993	Therefore, we investigated whether cyclic AMP, protein kinase A and NF kappa B are involved in the induction of IL-1 beta release by human peripheral blood monocyte-derived macrophages (HPBM) stimulated with a specific IL-1 beta inducer, 9-hydroxyoctadecadienoic acid (9-HODE).	Cyclic AMP	35-45	interleukin 1 beta	Homo sapiens	219-228
8144314-3	1993	Therefore, we investigated whether cyclic AMP, protein kinase A and NF kappa B are involved in the induction of IL-1 beta release by human peripheral blood monocyte-derived macrophages (HPBM) stimulated with a specific IL-1 beta inducer, 9-hydroxyoctadecadienoic acid (9-HODE).	hpbm	186-190	interleukin 1 beta	Homo sapiens	112-121
8144314-3	1993	Therefore, we investigated whether cyclic AMP, protein kinase A and NF kappa B are involved in the induction of IL-1 beta release by human peripheral blood monocyte-derived macrophages (HPBM) stimulated with a specific IL-1 beta inducer, 9-hydroxyoctadecadienoic acid (9-HODE).	hpbm	186-190	interleukin 1 beta	Homo sapiens	219-228
8144314-3	1993	Therefore, we investigated whether cyclic AMP, protein kinase A and NF kappa B are involved in the induction of IL-1 beta release by human peripheral blood monocyte-derived macrophages (HPBM) stimulated with a specific IL-1 beta inducer, 9-hydroxyoctadecadienoic acid (9-HODE).	9-hydroxyoctadecadienoic acid	238-267	interleukin 1 beta	Homo sapiens	112-121
8144314-5	1993	A role for cyclic AMP in IL-1 beta induction was suggested since forskolin was sufficient to induce IL-1 beta release from HPBM.	Cyclic AMP	11-21	interleukin 1 beta	Homo sapiens	25-34
8144314-5	1993	A role for cyclic AMP in IL-1 beta induction was suggested since forskolin was sufficient to induce IL-1 beta release from HPBM.	Colforsin	65-74	interleukin 1 beta	Homo sapiens	25-34
8144314-5	1993	A role for cyclic AMP in IL-1 beta induction was suggested since forskolin was sufficient to induce IL-1 beta release from HPBM.	Colforsin	65-74	interleukin 1 beta	Homo sapiens	100-109
8144314-7	1993	A requirement of protein kinase A in IL-1 beta induction was suggested since 9-HODE-induced IL-1 beta release was inhibited with a selective protein kinase A inhibitor, Rp-isomer (IC50:5 microM).	9-hydroxyoctadecadienoic acid	77-83	interleukin 1 beta	Homo sapiens	37-46
8144314-7	1993	A requirement of protein kinase A in IL-1 beta induction was suggested since 9-HODE-induced IL-1 beta release was inhibited with a selective protein kinase A inhibitor, Rp-isomer (IC50:5 microM).	9-hydroxyoctadecadienoic acid	77-83	interleukin 1 beta	Homo sapiens	92-101
8144314-8	1993	Lastly, to examine the role of NF kappa B, incubation of HPBM with a double-stranded oligodeoxyribonucleotide (ds-oligo) bearing the NF kappa B consensus sequence produced a dose-dependent enhancement of 9-HODE-induced IL-1 beta release, whereas a ds-oligo containing an unrelated Oct-1 motif had no effect.	Oligodeoxyribonucleotides	85-109	interleukin 1 beta	Homo sapiens	219-228
8341137-4	1993	The metabolite also stimulated IL-1 induced formation of 6-Keto PGF1 alpha, the stable breakdown product of PGI2, in a dose dependent manner.	Epoprostenol	108-112	interleukin 1 beta	Homo sapiens	31-35
8341137-5	1993	IL-1 beta induces release of [3H]-arachidonic acid ([3H]-AA) from prelabelled fibroblasts, which was potentiated by p-HPPH (&gt; or = 1.2 micrograms/ml).	Tritium	30-32	interleukin 1 beta	Homo sapiens	0-9
8341137-5	1993	IL-1 beta induces release of [3H]-arachidonic acid ([3H]-AA) from prelabelled fibroblasts, which was potentiated by p-HPPH (&gt; or = 1.2 micrograms/ml).	Arachidonic Acid	34-50	interleukin 1 beta	Homo sapiens	0-9
8341137-5	1993	IL-1 beta induces release of [3H]-arachidonic acid ([3H]-AA) from prelabelled fibroblasts, which was potentiated by p-HPPH (&gt; or = 1.2 micrograms/ml).	Tritium	53-55	interleukin 1 beta	Homo sapiens	0-9
8341137-5	1993	IL-1 beta induces release of [3H]-arachidonic acid ([3H]-AA) from prelabelled fibroblasts, which was potentiated by p-HPPH (&gt; or = 1.2 micrograms/ml).	p-hpph	116-122	interleukin 1 beta	Homo sapiens	0-9
8341137-8	1993	The results indicate that treatment with p-HPPH results in upregulation of prostaglandin synthesis in gingival fibroblasts challenged to IL-1 or TNF alpha at the level of phospholipase A2.	p-hpph	41-47	interleukin 1 beta	Homo sapiens	137-141
8341137-8	1993	The results indicate that treatment with p-HPPH results in upregulation of prostaglandin synthesis in gingival fibroblasts challenged to IL-1 or TNF alpha at the level of phospholipase A2.	Prostaglandins	75-88	interleukin 1 beta	Homo sapiens	137-141
8241800-4	1993	IL-1 beta, IL-3 or IL-5 gene expression was detected in cellular RNA isolated from both medium- and PAF-stimulated CBMCs using the reverse transcription polymerase chain reaction (RT-PCR) method; however, no expression of GM-CSF was detected.	cbmcs	115-120	interleukin 1 beta	Homo sapiens	0-9
8433563-10	1993	Western blot analysis of concentrated HPMC supernatants using specific anti-IL-6 antibody demonstrated immunoreactive bands at 23 and 28 Kd following IL-1 beta or TNF alpha treatment.	hydroxypropylmethylcellulose-lactose matrix	38-42	interleukin 1 beta	Homo sapiens	150-159
8341137-2	1993	IL-1 alpha, IL-1 beta and TNF alpha, dose-dependently, stimulated PGE2 formation in gingival fibroblasts.	Dinoprostone	66-70	interleukin 1 beta	Homo sapiens	12-21
8341137-3	1993	The metabolite, p-HPPH (1.2-2.4 micrograms/ml), did not induce PGE2 formation itself but potentiated IL-1 alpha and IL1 beta induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentration of both IL-1 and p-HPPH.	p-hpph	16-22	interleukin 1 beta	Homo sapiens	116-124
8341137-3	1993	The metabolite, p-HPPH (1.2-2.4 micrograms/ml), did not induce PGE2 formation itself but potentiated IL-1 alpha and IL1 beta induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentration of both IL-1 and p-HPPH.	p-hpph	16-22	interleukin 1 beta	Homo sapiens	101-105
8341137-3	1993	The metabolite, p-HPPH (1.2-2.4 micrograms/ml), did not induce PGE2 formation itself but potentiated IL-1 alpha and IL1 beta induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentration of both IL-1 and p-HPPH.	Dinoprostone	133-137	interleukin 1 beta	Homo sapiens	116-124
18475522-1	1993	Synthesis of IL-1beta and TNFalpha by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the muM range.	Benzylisoquinolines	103-125	interleukin 1 beta	Homo sapiens	13-21
18475522-1	1993	Synthesis of IL-1beta and TNFalpha by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the muM range.	Benzylisoquinolines	106-124	interleukin 1 beta	Homo sapiens	13-21
8489769-3	1993	Radioimmunoassay showed that after stimulation by RA, the IL-1 beta intracellular level is predominantly increased, with no significant modification of IL-1 alpha expression.	Tretinoin	50-52	interleukin 1 beta	Homo sapiens	58-67
8380885-6	1993	Treatment with the cyclooxygenase inhibitor indomethacin increased IL-1 beta and TNF-alpha secretion but not that of IL-6 or IL-8.	Indomethacin	44-56	interleukin 1 beta	Homo sapiens	67-76
8392688-2	1993	Massive liberation of bacterial cell wall components (Lipopolysaccharide, acid teichoic polymers) induce a cascade of reactions including the secretion of many cytokines (such as TNF alpha and IL-1 beta) and prostaglandins (such as PAF and PGE2) which in turn leads to the development of cerebral oedema, intracranial hypertension and cerebral blood flow reduction.	acid teichoic polymers	74-96	interleukin 1 beta	Homo sapiens	193-202
8392688-2	1993	Massive liberation of bacterial cell wall components (Lipopolysaccharide, acid teichoic polymers) induce a cascade of reactions including the secretion of many cytokines (such as TNF alpha and IL-1 beta) and prostaglandins (such as PAF and PGE2) which in turn leads to the development of cerebral oedema, intracranial hypertension and cerebral blood flow reduction.	Platelet Activating Factor	232-235	interleukin 1 beta	Homo sapiens	193-202
8392688-2	1993	Massive liberation of bacterial cell wall components (Lipopolysaccharide, acid teichoic polymers) induce a cascade of reactions including the secretion of many cytokines (such as TNF alpha and IL-1 beta) and prostaglandins (such as PAF and PGE2) which in turn leads to the development of cerebral oedema, intracranial hypertension and cerebral blood flow reduction.	Dinoprostone	240-244	interleukin 1 beta	Homo sapiens	193-202
8290803-0	1993	Quinacrine-induced pleural inflammation in malignant pleurisy: relation between drainage time of pleural fluid and local interleukin-1 beta levels.	Quinacrine	0-10	interleukin 1 beta	Homo sapiens	121-139
8290803-2	1993	IL-1 beta levels increased significantly within 24 h after the instillation of quinacrine (p &lt; 0.001).	Quinacrine	79-89	interleukin 1 beta	Homo sapiens	0-9
8489769-4	1993	The addition of hydrocortisone in the culture medium resulted in a decrease in RA-induced IL-1 beta overexpression, without notable modifications in untreated cultures.	Hydrocortisone	16-30	interleukin 1 beta	Homo sapiens	90-99
8489769-4	1993	The addition of hydrocortisone in the culture medium resulted in a decrease in RA-induced IL-1 beta overexpression, without notable modifications in untreated cultures.	Tretinoin	79-81	interleukin 1 beta	Homo sapiens	90-99
8489769-6	1993	The overexpression of IL-1 beta in control and RA-treated cultures mainly concerned the 52- and 31- to 36-kD biologically inactive precursor forms.	Tretinoin	47-49	interleukin 1 beta	Homo sapiens	22-31
8489769-7	1993	Northern blot using specific IL-1 alpha and -beta oligonucleotide probes showed that IL-1 beta mRNA predominate over IL-1 alpha mRNA and reach a maximal level 6 h before the IL-1 beta protein peak.	beta oligonucleotide	45-65	interleukin 1 beta	Homo sapiens	85-94
8489769-8	1993	These findings indicate that in cultured keratinocytes intracellular IL-1 beta is preferentially increased by RA but in its immature forms.	Tretinoin	110-112	interleukin 1 beta	Homo sapiens	69-78
8372524-10	1993	Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level.	Dinoprostone	6-22	interleukin 1 beta	Homo sapiens	78-87
8372524-10	1993	Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level.	Dinoprostone	6-22	interleukin 1 beta	Homo sapiens	204-213
8372524-10	1993	Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level.	Dinoprostone	24-28	interleukin 1 beta	Homo sapiens	78-87
8372524-10	1993	Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level.	Dinoprostone	24-28	interleukin 1 beta	Homo sapiens	204-213
8372524-10	1993	Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level.	Dinoprostone	150-154	interleukin 1 beta	Homo sapiens	78-87
8372524-10	1993	Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level.	Dinoprostone	150-154	interleukin 1 beta	Homo sapiens	204-213
8372524-10	1993	Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level.	Cyclic AMP	187-191	interleukin 1 beta	Homo sapiens	78-87
8372524-10	1993	Since Prostaglandin E2 (PGE2) has been found to have a vigorous impact on the IL-1 beta synthesis on the translational level, we assume that the high PGE2 levels post-trauma inhibit--via cAMP--sufficient IL-1 beta synthesis on the posttranscriptional level.	Cyclic AMP	187-191	interleukin 1 beta	Homo sapiens	204-213
1450407-2	1992	We have previously shown increased synthesis of interleukin-1 beta in lipopolysaccharide (LPS)-stimulated U937 cells after pretreatment with 10 nmol/L 1,25-(OH)2D3.	Calcitriol	151-163	interleukin 1 beta	Homo sapiens	48-66
1332947-4	1992	The secretory mechanism for thioredoxin shares several features with the alternative pathway described for interleukin-1 beta, such as the potentiating effect on secretion of several unrelated drugs and the sensitivity to methylamine.	methylamine	222-233	interleukin 1 beta	Homo sapiens	107-125
1332947-6	1992	In addition, when COS7 are transfected with plasmids encoding pro-interleukin-1 beta or thioredoxin, only the latter is detectable extracellularly.	cos7	18-22	interleukin 1 beta	Homo sapiens	62-84
1471697-7	1992	Endometrial explants responded to treatment with interleukin-1 beta and tumor necrosis factor by a concentration-dependent increase in the production of prostaglandin E2.	Dinoprostone	153-169	interleukin 1 beta	Homo sapiens	49-67
1471697-8	1992	Costimulation of late luteal endometrial explants with interleukin-1 beta (10 ng/ml) and progesterone (10(-6) mol/L) resulted in variable production of prostaglandin E2, suggesting that the histologic examination of the endometrium does not necessarily reflect the functional properties of the endometrium.	Dinoprostone	152-168	interleukin 1 beta	Homo sapiens	55-73
1459694-2	1992	We examined the cytokines interleukin-1-beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) for their effects on osteoblastic proliferation and development and expression of alkaline phosphate and the osteoblast-specific protein osteocalcin in a mineralizing environment.	alkaline phosphate	183-201	interleukin 1 beta	Homo sapiens	26-44
1336765-2	1992	When cultured in the presence of IL-1 beta these cell lines demonstrated a marked increase in interleukin-6 production and in [3H]-thymidine uptake.	Tritium	127-129	interleukin 1 beta	Homo sapiens	33-42
1336765-2	1992	When cultured in the presence of IL-1 beta these cell lines demonstrated a marked increase in interleukin-6 production and in [3H]-thymidine uptake.	Thymidine	131-140	interleukin 1 beta	Homo sapiens	33-42
1336765-3	1992	The addition of dbcAMP could mimic the first effect of IL-1 beta but at the same time suppressed cell proliferation.	Bucladesine	16-22	interleukin 1 beta	Homo sapiens	55-64
1459694-2	1992	We examined the cytokines interleukin-1-beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) for their effects on osteoblastic proliferation and development and expression of alkaline phosphate and the osteoblast-specific protein osteocalcin in a mineralizing environment.	alkaline phosphate	183-201	interleukin 1 beta	Homo sapiens	46-55
1336765-4	1992	These results suggest that IL-1 beta possibly exerts one of its biological effects (IL-6 synthesis) by means of the cyclic AMP pathway.	Cyclic AMP	116-126	interleukin 1 beta	Homo sapiens	27-36
1333514-13	1992	In summary, these studies suggest that interleukin 1-beta-mediated endothelial cell phospholipase A2 activity and prostacyclin synthesis occur via a novel transducing pathway that does not involve early activation of phospholipase C, phospholipase D, or adenylate cyclase.	Epoprostenol	114-126	interleukin 1 beta	Homo sapiens	39-57
1294780-5	1992	The results were as follows: (1) The production of IL-1 beta, TNF alpha and IL-6 in TB patients was significantly higher than that observed in the healthy control subjects.	Terbium	84-86	interleukin 1 beta	Homo sapiens	51-60
1333514-2	1992	We examined potential postreceptor transduction systems involved in human recombinant interleukin 1-beta-stimulated prostacyclin synthesis in human umbilical vein endothelium.	Epoprostenol	116-128	interleukin 1 beta	Homo sapiens	86-104
1333514-3	1992	Challenge of human umbilical vein endothelium monolayers with recombinant interleukin 1-beta resulted in dose- and time-dependent tritiated arachidonate release and prostacyclin synthesis consistent with phospholipase A2 activation.	Arachidonic Acid	140-152	interleukin 1 beta	Homo sapiens	74-92
1333514-3	1992	Challenge of human umbilical vein endothelium monolayers with recombinant interleukin 1-beta resulted in dose- and time-dependent tritiated arachidonate release and prostacyclin synthesis consistent with phospholipase A2 activation.	Epoprostenol	165-177	interleukin 1 beta	Homo sapiens	74-92
1333514-4	1992	Prostacyclin synthesis after interleukin 1-beta (10 ng/ml) was detected 4 hours after stimulation and peaked at 16 to 24 hours.	Epoprostenol	0-12	interleukin 1 beta	Homo sapiens	29-47
1333514-9	1992	The intracellular Ca++ antagonist BAPTA and the extracellular Ca++ chelator EGTA produced significant inhibition of interleukin 1-beta-stimulated prostacyclin generation at 4 to 8 hours, suggesting either an indirect inhibitory effect of these agents on phospholipase A2 activity or that an increase in Ca++ may be a late event in the transduction scheme after interleukin 1 stimulation.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	34-39	interleukin 1 beta	Homo sapiens	116-134
1333514-9	1992	The intracellular Ca++ antagonist BAPTA and the extracellular Ca++ chelator EGTA produced significant inhibition of interleukin 1-beta-stimulated prostacyclin generation at 4 to 8 hours, suggesting either an indirect inhibitory effect of these agents on phospholipase A2 activity or that an increase in Ca++ may be a late event in the transduction scheme after interleukin 1 stimulation.	Egtazic Acid	76-80	interleukin 1 beta	Homo sapiens	116-134
1333514-9	1992	The intracellular Ca++ antagonist BAPTA and the extracellular Ca++ chelator EGTA produced significant inhibition of interleukin 1-beta-stimulated prostacyclin generation at 4 to 8 hours, suggesting either an indirect inhibitory effect of these agents on phospholipase A2 activity or that an increase in Ca++ may be a late event in the transduction scheme after interleukin 1 stimulation.	Epoprostenol	146-158	interleukin 1 beta	Homo sapiens	116-134
1464740-4	1992	IL-1 beta and TNF alpha production in whole blood samples was stimulated with endotoxin and/or phytohemagglutinin in standard EDTA-containing vacuum collection tubes.	Edetic Acid	126-130	interleukin 1 beta	Homo sapiens	0-9
1466764-0	1992	Chemical modification of interleukin-1 beta: biochemical characterization of a carbodiimide-catalyzed intramolecular cross-linked protein.	Carbodiimides	79-91	interleukin 1 beta	Homo sapiens	25-43
1466764-1	1992	We have modified recombinant human Interleukin-1 beta using 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide at pH 6.5, resulting in the formation of an internally cross-linked protein.	Ethyldimethylaminopropyl Carbodiimide	60-105	interleukin 1 beta	Homo sapiens	35-53
1294780-6	1992	(2) The production of IL-1 beta, TNF alpha and IL-6 in TB+DM patients was significantly lower than that observed in the TB patients.	Terbium	55-57	interleukin 1 beta	Homo sapiens	22-31
1294780-7	1992	(3) The production of IL-1 beta and TNF alpha in TB+DM patients with poor control was significantly lower than that observed in the patients with good control.	Terbium	49-51	interleukin 1 beta	Homo sapiens	22-31
1337210-5	1992	Pretreatment of decidua cells with interleukin-1 beta (IL-1 beta) enhanced PGF2 alpha production but not arachidonate release in response to ET-1.	Dinoprost	75-79	interleukin 1 beta	Homo sapiens	55-64
1484875-0	1992	Food intake and body temperature responses of rats to recombinant human interleukin-1 beta and a tripeptide interleukin-1 beta antagonist.	tripeptide K-26	97-107	interleukin 1 beta	Homo sapiens	108-126
1334783-9	1992	Subsequently, we investigated the capacity of nedocromil to affect the capacity of IgE plus anti-IgE complexes, allergen, and LPS (16 hr/37 degrees C) to stimulate IL-1 beta and IL-6 production.	Nedocromil	46-56	interleukin 1 beta	Homo sapiens	164-173
1451738-0	1992	Dexamethasone attenuates altered insulin secretion elicited by interleukin-1 beta in HIT cells.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	63-81
1451738-2	1992	The addition of IL-1 from 1.2 x 10(-8) to 10(-10) M increased insulin secretion in the 0-4-h period after IL-1 administration and prostaglandin E2 (PGE2) production was suppressed by IL-1 from 1.2 x 10(-8) to 10(-12) M. At all doses used, IL-1 inhibited insulin secretion in the 4-24-h period after IL-1 administration and PGE2 levels were increased in the culture medium.	Dinoprostone	130-146	interleukin 1 beta	Homo sapiens	16-20
1451738-2	1992	The addition of IL-1 from 1.2 x 10(-8) to 10(-10) M increased insulin secretion in the 0-4-h period after IL-1 administration and prostaglandin E2 (PGE2) production was suppressed by IL-1 from 1.2 x 10(-8) to 10(-12) M. At all doses used, IL-1 inhibited insulin secretion in the 4-24-h period after IL-1 administration and PGE2 levels were increased in the culture medium.	Dinoprostone	148-152	interleukin 1 beta	Homo sapiens	16-20
1451738-2	1992	The addition of IL-1 from 1.2 x 10(-8) to 10(-10) M increased insulin secretion in the 0-4-h period after IL-1 administration and prostaglandin E2 (PGE2) production was suppressed by IL-1 from 1.2 x 10(-8) to 10(-12) M. At all doses used, IL-1 inhibited insulin secretion in the 4-24-h period after IL-1 administration and PGE2 levels were increased in the culture medium.	Dinoprostone	323-327	interleukin 1 beta	Homo sapiens	16-20
1451738-3	1992	In the second experiment, the addition of 10(-7) M dexamethasone prevented the inhibitory effects of IL-1 on insulin secretion.	Dexamethasone	51-64	interleukin 1 beta	Homo sapiens	101-105
1451738-4	1992	In the third experiment, dexamethasone at 10(-7) M attenuated both the short-term stimulation of insulin release and the long-term suppression of insulin release caused by IL-1.	Dexamethasone	25-38	interleukin 1 beta	Homo sapiens	172-176
1451738-5	1992	It also prevented the effects of IL-1 on PGE2 production.	Dinoprostone	41-45	interleukin 1 beta	Homo sapiens	33-37
1451738-6	1992	The present studies suggest that dexamethasone may have a suppressive action on the effects of IL-1 on in vitro insulin secretion.	Dexamethasone	33-46	interleukin 1 beta	Homo sapiens	95-99
1443100-2	1992	The amiloride analogue 5-(N-ethyl-N-isopropyl)amiloride (EIPA), an inhibitor of the Na(+)-H+ antiporter, inhibited extracellular IL-1 beta.	Amiloride	4-13	interleukin 1 beta	Homo sapiens	129-138
1443100-2	1992	The amiloride analogue 5-(N-ethyl-N-isopropyl)amiloride (EIPA), an inhibitor of the Na(+)-H+ antiporter, inhibited extracellular IL-1 beta.	ethylisopropylamiloride	23-55	interleukin 1 beta	Homo sapiens	129-138
1443100-2	1992	The amiloride analogue 5-(N-ethyl-N-isopropyl)amiloride (EIPA), an inhibitor of the Na(+)-H+ antiporter, inhibited extracellular IL-1 beta.	ethylisopropylamiloride	57-61	interleukin 1 beta	Homo sapiens	129-138
1443100-6	1992	EIPA at 10 microM inhibited the Na+ influx, the rise in pHi, and intra- and extracellular IL-1 beta production in activated monocytes; this inhibition was reversed by 10 nM monensin.	ethylisopropylamiloride	0-4	interleukin 1 beta	Homo sapiens	90-99
1443100-6	1992	EIPA at 10 microM inhibited the Na+ influx, the rise in pHi, and intra- and extracellular IL-1 beta production in activated monocytes; this inhibition was reversed by 10 nM monensin.	Monensin	173-181	interleukin 1 beta	Homo sapiens	90-99
1443100-7	1992	In the absence of bicarbonate, or in the presence of 10 microM 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid, the pHi of activated monocytes and the total protein synthesis did not change, but the production of IL-1 beta was inhibited.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	63-111	interleukin 1 beta	Homo sapiens	214-223
1472962-8	1992	Intracisternal injection of CRF (10 micrograms), bombesin (0.1 microgram) and human recombinant interleukin-1 beta (hIL-1 beta, 0.1 microgram) inhibited gastric acid response to pentagastrin by 72%, 56% and 62%, respectively.	Pentagastrin	178-190	interleukin 1 beta	Homo sapiens	96-114
1472962-8	1992	Intracisternal injection of CRF (10 micrograms), bombesin (0.1 microgram) and human recombinant interleukin-1 beta (hIL-1 beta, 0.1 microgram) inhibited gastric acid response to pentagastrin by 72%, 56% and 62%, respectively.	Pentagastrin	178-190	interleukin 1 beta	Homo sapiens	116-126
1327576-2	1992	Stimulation of thymidine incorporation by basic fibroblast growth factor or epidermal growth factor treatment of cultured quiescent smooth muscle cells (rat and human) was attenuated by the concomitant treatment with interleukin-1 beta in the presence of indomethacin.	Thymidine	15-24	interleukin 1 beta	Homo sapiens	217-235
1327576-2	1992	Stimulation of thymidine incorporation by basic fibroblast growth factor or epidermal growth factor treatment of cultured quiescent smooth muscle cells (rat and human) was attenuated by the concomitant treatment with interleukin-1 beta in the presence of indomethacin.	Indomethacin	255-267	interleukin 1 beta	Homo sapiens	217-235
1327576-4	1992	Elevation of nitrite levels in the conditioned medium of cultures exposed to interleukin-1 beta correlated with the inhibition of thymidine incorporation.	Nitrites	13-20	interleukin 1 beta	Homo sapiens	77-95
1327576-4	1992	Elevation of nitrite levels in the conditioned medium of cultures exposed to interleukin-1 beta correlated with the inhibition of thymidine incorporation.	Thymidine	130-139	interleukin 1 beta	Homo sapiens	77-95
1337210-5	1992	Pretreatment of decidua cells with interleukin-1 beta (IL-1 beta) enhanced PGF2 alpha production but not arachidonate release in response to ET-1.	Dinoprost	75-79	interleukin 1 beta	Homo sapiens	35-53
1443157-7	1992	Furthermore, we showed the dose- and time-dependent suppression of IL-1 beta-stimulated PF-derived MCP-1 by dexamethasone and prostaglandin E2.	Dexamethasone	108-121	interleukin 1 beta	Homo sapiens	67-76
1443157-7	1992	Furthermore, we showed the dose- and time-dependent suppression of IL-1 beta-stimulated PF-derived MCP-1 by dexamethasone and prostaglandin E2.	Dinoprostone	126-142	interleukin 1 beta	Homo sapiens	67-76
1445491-5	1992	Cholesterol biosynthesis from [14C]acetate, in contrast to the stimulation of LDL receptor activity, was inhibited by approximately two-fold by incubation with TGF-beta 1 at 50 ng/ml and IL-1 beta at 11,700 units/ml.	Cholesterol	0-11	interleukin 1 beta	Homo sapiens	187-196
1445491-5	1992	Cholesterol biosynthesis from [14C]acetate, in contrast to the stimulation of LDL receptor activity, was inhibited by approximately two-fold by incubation with TGF-beta 1 at 50 ng/ml and IL-1 beta at 11,700 units/ml.	[14c]acetate	30-42	interleukin 1 beta	Homo sapiens	187-196
1338913-0	1992	The relationship between polysaccharide antigen and interleukin-1 beta producing activity in Porphyromonas gingivalis.	Polysaccharides	25-39	interleukin 1 beta	Homo sapiens	52-70
1338913-6	1992	The results of immunoblotting tests and IL-1 beta production indicated that there are serogroup-specific polysaccharide other than lipopolysaccharide in P. gingivalis.	Polysaccharides	105-119	interleukin 1 beta	Homo sapiens	40-49
1424289-2	1992	In this study we have examined the effects of the corticosteroid prednisolone on the production of IL-1 alpha and IL-1 beta by lipopolysaccharide (LPS)-stimulated monocytes, and the ability of the monocyte conditioned media (MOCM) obtained under these conditions to induce human hepatoma HepG2 cells to produce serum amyloid A (SAA) and C-reactive protein (CRP).	Prednisolone	65-77	interleukin 1 beta	Homo sapiens	114-123
1424289-4	1992	The findings indicate: (i) prednisolone substantially inhibits the production of both IL-1 alpha and IL-1 beta by LPS-stimulated monocytes.	Prednisolone	27-39	interleukin 1 beta	Homo sapiens	101-110
1424289-5	1992	The MOCM from prednisolone-treated monocytes induced less SAA and CRP production by HepG2 cells; (ii) IL-1 alpha and IL-1 beta both induced CRP and SAA synthesis by HepG2 cells, but only in the presence of IL-6.	Prednisolone	14-26	interleukin 1 beta	Homo sapiens	117-126
1327576-5	1992	Platelet-derived growth factor-AB and -BB inhibited the production of nitric oxide (measured as nitrite levels in conditioned medium) by cells treated simultaneously with interleukin-1 beta and growth factor.	Nitric Oxide	70-82	interleukin 1 beta	Homo sapiens	171-207
1327576-5	1992	Platelet-derived growth factor-AB and -BB inhibited the production of nitric oxide (measured as nitrite levels in conditioned medium) by cells treated simultaneously with interleukin-1 beta and growth factor.	Nitrites	96-103	interleukin 1 beta	Homo sapiens	171-207
1425414-5	1992	During the infusion of 2.0 micrograms IL-1/day, the decrease in plasma free T4 levels was paralleled by a significant decline in plasma TSH values and an impaired TSH responsiveness to TRH administration on the second day of infusion.	Thyrotropin	136-139	interleukin 1 beta	Homo sapiens	38-42
1331181-3	1992	At a concentration of 1% (vol/vol), DMSO blocked IL-8 release by approximately 90% in the presence of 1 microgram/ml LPS at a 24-h time point, but did not affect cell viability or reduce the production of tumor necrosis factor (TNF), interleukin 6, or interleukin-1 beta (IL-1 beta).	Dimethyl Sulfoxide	36-40	interleukin 1 beta	Homo sapiens	252-270
1331181-3	1992	At a concentration of 1% (vol/vol), DMSO blocked IL-8 release by approximately 90% in the presence of 1 microgram/ml LPS at a 24-h time point, but did not affect cell viability or reduce the production of tumor necrosis factor (TNF), interleukin 6, or interleukin-1 beta (IL-1 beta).	Dimethyl Sulfoxide	36-40	interleukin 1 beta	Homo sapiens	272-281
1331181-5	1992	Furthermore, this effect was not LPS-specific, in that IL-8 production was reduced by DMSO to a similar extent upon stimulation of blood with phytohemagglutinin, aggregated immune complexes, TNF, or IL-1 beta.	Dimethyl Sulfoxide	86-90	interleukin 1 beta	Homo sapiens	199-208
1337000-0	1992	Proton, carbon, and nitrogen chemical shifts accurately delineate differences and similarities in secondary structure between the homologous proteins IRAP and IL-1 beta.	Nitrogen	20-28	interleukin 1 beta	Homo sapiens	159-168
1337000-1	1992	1H alpha, 13C alpha, and 15N alpha secondary shifts, defined as the difference between the observed value and the random coil value, have been calculated for interleukin-1 receptor antagonist protein and interleukin-1 beta.	Hydrogen	0-2	interleukin 1 beta	Homo sapiens	204-222
1401931-8	1992	However, total IL-1 beta protein production, as measured by [35S]methionine labeling with immunoprecipitation, demonstrated three- to sixfold higher amounts in macrophages at comparable time points.	Sulfur-35	61-64	interleukin 1 beta	Homo sapiens	15-24
1401931-8	1992	However, total IL-1 beta protein production, as measured by [35S]methionine labeling with immunoprecipitation, demonstrated three- to sixfold higher amounts in macrophages at comparable time points.	Methionine	65-75	interleukin 1 beta	Homo sapiens	15-24
1401932-11	1992	Administration of a single 50-mg dose of prednisone at 3 p.m. resulted in diminished IL-1 beta protein concentration in the BAL fluid (28.3 +/- 5.7 pg/ml; p &lt; 0.01 compared to baseline) and completely abrogated IL-1 beta mRNA expression.	Prednisone	41-51	interleukin 1 beta	Homo sapiens	85-94
1401932-11	1992	Administration of a single 50-mg dose of prednisone at 3 p.m. resulted in diminished IL-1 beta protein concentration in the BAL fluid (28.3 +/- 5.7 pg/ml; p &lt; 0.01 compared to baseline) and completely abrogated IL-1 beta mRNA expression.	Prednisone	41-51	interleukin 1 beta	Homo sapiens	214-223
1431212-5	1992	The effects of hydrocortisone, dexamethasone, calcitriol, acitretin, and cyclosporin A on TNF- or IL-1 beta-induced IL-6 production by HDMEC were determined by ELISA.	Acitretin	58-67	interleukin 1 beta	Homo sapiens	98-107
1431212-5	1992	The effects of hydrocortisone, dexamethasone, calcitriol, acitretin, and cyclosporin A on TNF- or IL-1 beta-induced IL-6 production by HDMEC were determined by ELISA.	Cyclosporine	73-86	interleukin 1 beta	Homo sapiens	98-107
1289500-2	1992	In vitro effects of 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-on e (T-614), a novel antiinflammatory compound, on the production of interleukin-1 (IL-1) and/or interleukin-6 (IL-6) by human monocytes and the THP-1 cells of a human monocytic cell line, were examined.	3-formylamino-7-methylsulfonylamino-6-phenoxy-4h-1-benzopyran-4	20-83	interleukin 1 beta	Homo sapiens	154-174
1289500-3	1992	T-614 inhibited the release of immunoreactive IL-1 beta from these cells stimulated with lipopolysaccharides (LPS) in a dose-dependent manner (0.3-30 micrograms/ml).	T 614	0-5	interleukin 1 beta	Homo sapiens	46-55
1289500-5	1992	Northern blotting analysis using LPS-stimulated THP-1 cells indicated that the inhibitory effect of T-614 on IL-1 beta production is caused by the suppression of IL-1 beta mRNA expression.	T 614	100-105	interleukin 1 beta	Homo sapiens	109-118
1289500-5	1992	Northern blotting analysis using LPS-stimulated THP-1 cells indicated that the inhibitory effect of T-614 on IL-1 beta production is caused by the suppression of IL-1 beta mRNA expression.	T 614	100-105	interleukin 1 beta	Homo sapiens	162-171
1460092-1	1992	Iodine-125-labelled recombinant human interleukin-1 (IL-1) receptor antagonist ([125I]IL-1ra) was utilized to further determine the characteristics of IL-1 receptors in the brain-endocrine-immune axis.	Iodine	0-6	interleukin 1 beta	Homo sapiens	53-57
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 beta	Homo sapiens	105-123
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 beta	Homo sapiens	125-134
1292632-8	1992	Glucocorticoids did not detectably affect IL-1 alpha or IL-1 beta mRNA levels following PMA induction, however, staurosporin inhibited IL-1 beta mRNA synthesis.	Staurosporine	112-124	interleukin 1 beta	Homo sapiens	135-144
1334474-0	1992	Stimulation of human monocyte beta-glucan receptors by glucan particles induces production of TNF-alpha and IL-1 beta.	Glucans	35-41	interleukin 1 beta	Homo sapiens	108-117
1334474-4	1992	By enzyme-linked immunosorbent assays (ELISAs), significant levels of TNF-alpha and IL-1 beta were present in supernatants of glucan-treated cells within 1 h and plateau levels of both cytokines were approached within 4 h. At particle-to-cell ratios of from 0.4 to 18, glucan particles induced dose-dependent increases in TNF-alpha and IL-1 beta mRNA and corresponding increases in TNF-alpha and IL-1 beta proteins.	Glucans	126-132	interleukin 1 beta	Homo sapiens	84-93
1334474-4	1992	By enzyme-linked immunosorbent assays (ELISAs), significant levels of TNF-alpha and IL-1 beta were present in supernatants of glucan-treated cells within 1 h and plateau levels of both cytokines were approached within 4 h. At particle-to-cell ratios of from 0.4 to 18, glucan particles induced dose-dependent increases in TNF-alpha and IL-1 beta mRNA and corresponding increases in TNF-alpha and IL-1 beta proteins.	Glucans	126-132	interleukin 1 beta	Homo sapiens	336-345
1334474-4	1992	By enzyme-linked immunosorbent assays (ELISAs), significant levels of TNF-alpha and IL-1 beta were present in supernatants of glucan-treated cells within 1 h and plateau levels of both cytokines were approached within 4 h. At particle-to-cell ratios of from 0.4 to 18, glucan particles induced dose-dependent increases in TNF-alpha and IL-1 beta mRNA and corresponding increases in TNF-alpha and IL-1 beta proteins.	Glucans	126-132	interleukin 1 beta	Homo sapiens	336-345
1334474-4	1992	By enzyme-linked immunosorbent assays (ELISAs), significant levels of TNF-alpha and IL-1 beta were present in supernatants of glucan-treated cells within 1 h and plateau levels of both cytokines were approached within 4 h. At particle-to-cell ratios of from 0.4 to 18, glucan particles induced dose-dependent increases in TNF-alpha and IL-1 beta mRNA and corresponding increases in TNF-alpha and IL-1 beta proteins.	Glucans	269-275	interleukin 1 beta	Homo sapiens	84-93
1334474-5	1992	Exposure of monocytes to glucan particles for 0-30 min and washing before continued incubation for 4 h in particle-free buffer induced production and secretion of TNF-alpha and IL-1 beta in a time-dependent fashion compatible with phagocytosis.	Glucans	25-31	interleukin 1 beta	Homo sapiens	177-186
1334474-6	1992	The pretreatment of monocyte monolayers with trypsin reduced glucan-induced production of TNF-alpha and IL-1 beta in a dose-dependent manner with 5 micrograms/ml of trypsin effecting reductions of greater than 50%.	Glucans	61-67	interleukin 1 beta	Homo sapiens	104-113
1334474-7	1992	Thus, glucan particles induce human monocyte production of TNF-alpha and IL-1 beta by a mechanism that is dependent on trypsin-sensitive beta-glucan receptors.	Glucans	6-12	interleukin 1 beta	Homo sapiens	73-82
1425414-5	1992	During the infusion of 2.0 micrograms IL-1/day, the decrease in plasma free T4 levels was paralleled by a significant decline in plasma TSH values and an impaired TSH responsiveness to TRH administration on the second day of infusion.	Thyrotropin	163-166	interleukin 1 beta	Homo sapiens	38-42
1425414-10	1992	Restriction of food consumption to the level observed in the 2.0 micrograms IL-1 experiment caused small decreases in T3, total and free T4, and TSH levels compared to those in ad libitum fed rats, but had no effects on T4 binding.	Thyrotropin	145-148	interleukin 1 beta	Homo sapiens	76-80
1445301-3	1992	The stimulating effect of IL-1 beta on iR-ET production was respectively inhibited by protein kinase C (C kinase) inhibitor (H-7), Ca-calmodulin inhibitor (W-7), cyclic AMP-dependent protein kinase (A kinase) inhibitor (H-8) and tyrosine kinase inhibitor (genistain) in a dose-dependent fashion.	W 7	156-159	interleukin 1 beta	Homo sapiens	26-35
1445301-3	1992	The stimulating effect of IL-1 beta on iR-ET production was respectively inhibited by protein kinase C (C kinase) inhibitor (H-7), Ca-calmodulin inhibitor (W-7), cyclic AMP-dependent protein kinase (A kinase) inhibitor (H-8) and tyrosine kinase inhibitor (genistain) in a dose-dependent fashion.	genistain	256-265	interleukin 1 beta	Homo sapiens	26-35
1384479-5	1992	The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1 alpha and IL-1 beta on the production of HGF.	tetradecanoylphorbol 13-acetate	20-51	interleukin 1 beta	Homo sapiens	117-126
1382715-7	1992	PMN surviving in response to LPS or IL-1 beta retained the capacity to produce superoxide anion when treated with phorbol esters or fMLP.	Superoxides	79-95	interleukin 1 beta	Homo sapiens	36-45
1382715-7	1992	PMN surviving in response to LPS or IL-1 beta retained the capacity to produce superoxide anion when treated with phorbol esters or fMLP.	Phorbol Esters	114-128	interleukin 1 beta	Homo sapiens	36-45
1384479-5	1992	The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1 alpha and IL-1 beta on the production of HGF.	Tetradecanoylphorbol Acetate	53-56	interleukin 1 beta	Homo sapiens	117-126
1384479-6	1992	The stimulatory effect of both IL-1 alpha and IL-1 beta and the synergistical stimulation with TPA were completely abrogated by 10 ng/ml TGF-beta 1 or 1 microM dexamethasone.	Dexamethasone	160-173	interleukin 1 beta	Homo sapiens	46-55
1390901-0	1992	Interleukin-1 beta enhances the response of human articular chondrocytes to extracellular ATP.	Adenosine Triphosphate	90-93	interleukin 1 beta	Homo sapiens	0-18
1390901-1	1992	It has been observed that both interleukin-1 (IL-1) and extracellular ATP stimulate the production of prostaglandin E (PGE) by human articular chondrocytes in monolayer culture.	Prostaglandins E	102-117	interleukin 1 beta	Homo sapiens	31-50
1390901-1	1992	It has been observed that both interleukin-1 (IL-1) and extracellular ATP stimulate the production of prostaglandin E (PGE) by human articular chondrocytes in monolayer culture.	Prostaglandins E	119-122	interleukin 1 beta	Homo sapiens	31-50
1400321-2	1992	We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol.	Sphingosine	30-41	interleukin 1 beta	Homo sapiens	51-69
1400321-2	1992	We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol.	Sphingosine	30-41	interleukin 1 beta	Homo sapiens	71-75
1390901-3	1992	IL-1 beta rapidly enhanced the response to a maximally effective concentration of ATP (100 microM).	Adenosine Triphosphate	82-85	interleukin 1 beta	Homo sapiens	0-9
1400321-2	1992	We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol.	Dinoprostone	86-102	interleukin 1 beta	Homo sapiens	51-69
1390901-6	1992	The enhancement of the response to 100 microM ATP by IL-1 beta was dose-dependent.	Adenosine Triphosphate	46-49	interleukin 1 beta	Homo sapiens	53-62
1400321-2	1992	We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol.	Dinoprostone	86-102	interleukin 1 beta	Homo sapiens	71-75
1390901-9	1992	IL-1 beta lowered the minimum concentration of ATP required to elicit an increase in the production of PGE by human articular chondrocytes.	Adenosine Triphosphate	47-50	interleukin 1 beta	Homo sapiens	0-9
1400321-2	1992	We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol.	Dinoprostone	104-108	interleukin 1 beta	Homo sapiens	51-69
1400321-2	1992	We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human dermal fibroblasts (Ballou, L. R., Barker, S. C., Postlethwaite, A. E., and Kang, A. H. (1990) J. Immunol.	Dinoprostone	104-108	interleukin 1 beta	Homo sapiens	71-75
1390901-9	1992	IL-1 beta lowered the minimum concentration of ATP required to elicit an increase in the production of PGE by human articular chondrocytes.	Prostaglandins E	103-106	interleukin 1 beta	Homo sapiens	0-9
1400321-4	1992	Because sphingosine and ceramide are interconvertable, we extended previous studies by treating cells with C2-ceramide (C2-cer), a membrane-soluble analogue of ceramide, and found that C2-cer stimulates IL-1-mediated PGE2 production to the same degree as sphingosine.	Sphingosine	8-19	interleukin 1 beta	Homo sapiens	203-207
1396331-6	1992	Human recombinant IL-1 beta caused a dose-dependent stimulation in the incorporation of [3H]thymidine into DNA in the Leydig cells from 10- and 20-day-old rats but had no effect on DNA synthesis in interstitial cells from adult rats.	Tritium	89-91	interleukin 1 beta	Homo sapiens	18-27
1400321-4	1992	Because sphingosine and ceramide are interconvertable, we extended previous studies by treating cells with C2-ceramide (C2-cer), a membrane-soluble analogue of ceramide, and found that C2-cer stimulates IL-1-mediated PGE2 production to the same degree as sphingosine.	N-acetylsphingosine	107-118	interleukin 1 beta	Homo sapiens	203-207
1400321-4	1992	Because sphingosine and ceramide are interconvertable, we extended previous studies by treating cells with C2-ceramide (C2-cer), a membrane-soluble analogue of ceramide, and found that C2-cer stimulates IL-1-mediated PGE2 production to the same degree as sphingosine.	Ceramides	110-118	interleukin 1 beta	Homo sapiens	203-207
1400321-8	1992	We also found that IL-1-mediated PGE2 production was dramatically enhanced in cells treated simultaneously with sphingomyelinase which led us to directly test the effect of IL-1 on sphingomyelin turnover.	Dinoprostone	33-37	interleukin 1 beta	Homo sapiens	19-23
1400321-9	1992	IL-1 treatment induced the hydrolysis of a significant fraction of prelabeled sphingomyelin which was accompanied by increased levels of intracellular ceramide.	Sphingomyelins	78-91	interleukin 1 beta	Homo sapiens	0-4
1400321-9	1992	IL-1 treatment induced the hydrolysis of a significant fraction of prelabeled sphingomyelin which was accompanied by increased levels of intracellular ceramide.	Ceramides	151-159	interleukin 1 beta	Homo sapiens	0-4
1400321-10	1992	Taken together, our results suggest that enhanced Cox expression may account for the observed enhancement of IL-1-mediated PGE2 production by sphingosine and C2-cer.	Dinoprostone	123-127	interleukin 1 beta	Homo sapiens	109-113
1400321-10	1992	Taken together, our results suggest that enhanced Cox expression may account for the observed enhancement of IL-1-mediated PGE2 production by sphingosine and C2-cer.	Sphingosine	142-153	interleukin 1 beta	Homo sapiens	109-113
1400321-10	1992	Taken together, our results suggest that enhanced Cox expression may account for the observed enhancement of IL-1-mediated PGE2 production by sphingosine and C2-cer.	N-acetylsphingosine	158-164	interleukin 1 beta	Homo sapiens	109-113
1400321-11	1992	These data also suggest that endogenous sphingomyelin metabolites, generated in response to IL-1, may play an important role in IL-1 signal transduction.	Sphingomyelins	40-53	interleukin 1 beta	Homo sapiens	92-96
1400321-11	1992	These data also suggest that endogenous sphingomyelin metabolites, generated in response to IL-1, may play an important role in IL-1 signal transduction.	Sphingomyelins	40-53	interleukin 1 beta	Homo sapiens	128-132
1384465-13	1992	These results show that IL-1 beta-induced nitric oxide formation parallels the ability of IL-1 beta to inhibit glucose-stimulated insulin secretion by islets, and that protein synthesis is required for IL-1 beta-induced nitric oxide formation.	Nitric Oxide	42-54	interleukin 1 beta	Homo sapiens	24-33
1384465-13	1992	These results show that IL-1 beta-induced nitric oxide formation parallels the ability of IL-1 beta to inhibit glucose-stimulated insulin secretion by islets, and that protein synthesis is required for IL-1 beta-induced nitric oxide formation.	Glucose	111-118	interleukin 1 beta	Homo sapiens	24-33
1384465-13	1992	These results show that IL-1 beta-induced nitric oxide formation parallels the ability of IL-1 beta to inhibit glucose-stimulated insulin secretion by islets, and that protein synthesis is required for IL-1 beta-induced nitric oxide formation.	Glucose	111-118	interleukin 1 beta	Homo sapiens	90-99
1384465-13	1992	These results show that IL-1 beta-induced nitric oxide formation parallels the ability of IL-1 beta to inhibit glucose-stimulated insulin secretion by islets, and that protein synthesis is required for IL-1 beta-induced nitric oxide formation.	Glucose	111-118	interleukin 1 beta	Homo sapiens	90-99
1384465-13	1992	These results show that IL-1 beta-induced nitric oxide formation parallels the ability of IL-1 beta to inhibit glucose-stimulated insulin secretion by islets, and that protein synthesis is required for IL-1 beta-induced nitric oxide formation.	Nitric Oxide	220-232	interleukin 1 beta	Homo sapiens	24-33
1384465-14	1992	These results also suggest that nitric oxide mediates IL-1 beta-induced inhibitory effects on the pancreatic beta-cell by functioning as an effector molecule responsible for the destruction of iron-sulphur centres of iron-containing proteins, resulting in an impairment of mitochondrial function.	Nitric Oxide	32-44	interleukin 1 beta	Homo sapiens	54-63
1384465-14	1992	These results also suggest that nitric oxide mediates IL-1 beta-induced inhibitory effects on the pancreatic beta-cell by functioning as an effector molecule responsible for the destruction of iron-sulphur centres of iron-containing proteins, resulting in an impairment of mitochondrial function.	Iron	193-197	interleukin 1 beta	Homo sapiens	54-63
1384465-14	1992	These results also suggest that nitric oxide mediates IL-1 beta-induced inhibitory effects on the pancreatic beta-cell by functioning as an effector molecule responsible for the destruction of iron-sulphur centres of iron-containing proteins, resulting in an impairment of mitochondrial function.	Iron	217-221	interleukin 1 beta	Homo sapiens	54-63
1384465-0	1992	Nitric oxide and cyclic GMP formation induced by interleukin 1 beta in islets of Langerhans.	Nitric Oxide	0-12	interleukin 1 beta	Homo sapiens	49-67
1384465-0	1992	Nitric oxide and cyclic GMP formation induced by interleukin 1 beta in islets of Langerhans.	Cyclic GMP	17-27	interleukin 1 beta	Homo sapiens	49-67
1384465-2	1992	Treatment of pancreatic islets with interleukin 1 (IL-1) results in a time-dependent inhibition of glucose-stimulated insulin secretion which has recently been demonstrated to be dependent on the metabolism of L-arginine to nitric oxide.	Glucose	99-106	interleukin 1 beta	Homo sapiens	36-55
1384465-2	1992	Treatment of pancreatic islets with interleukin 1 (IL-1) results in a time-dependent inhibition of glucose-stimulated insulin secretion which has recently been demonstrated to be dependent on the metabolism of L-arginine to nitric oxide.	Arginine	210-220	interleukin 1 beta	Homo sapiens	36-55
1384465-2	1992	Treatment of pancreatic islets with interleukin 1 (IL-1) results in a time-dependent inhibition of glucose-stimulated insulin secretion which has recently been demonstrated to be dependent on the metabolism of L-arginine to nitric oxide.	Nitric Oxide	224-236	interleukin 1 beta	Homo sapiens	36-55
1384465-3	1992	In this report IL-1 beta is shown to induce the accumulation of cyclic GMP (cGMP) in a time-dependent fashion that mimics the time-dependent inhibition of insulin secretion by IL-1 beta.	Cyclic GMP	64-74	interleukin 1 beta	Homo sapiens	15-24
1384465-3	1992	In this report IL-1 beta is shown to induce the accumulation of cyclic GMP (cGMP) in a time-dependent fashion that mimics the time-dependent inhibition of insulin secretion by IL-1 beta.	Cyclic GMP	64-74	interleukin 1 beta	Homo sapiens	176-185
1384465-3	1992	In this report IL-1 beta is shown to induce the accumulation of cyclic GMP (cGMP) in a time-dependent fashion that mimics the time-dependent inhibition of insulin secretion by IL-1 beta.	Cyclic GMP	76-80	interleukin 1 beta	Homo sapiens	15-24
1384465-3	1992	In this report IL-1 beta is shown to induce the accumulation of cyclic GMP (cGMP) in a time-dependent fashion that mimics the time-dependent inhibition of insulin secretion by IL-1 beta.	Cyclic GMP	76-80	interleukin 1 beta	Homo sapiens	176-185
1384465-4	1992	The accumulation of cGMP is dependent on nitric oxide synthase activity, since NG-monomethyl-L-arginine (a competitive inhibitor of nitric oxide synthase) prevents IL-1 beta-induced cGMP accumulation.	Cyclic GMP	20-24	interleukin 1 beta	Homo sapiens	164-173
1384465-4	1992	The accumulation of cGMP is dependent on nitric oxide synthase activity, since NG-monomethyl-L-arginine (a competitive inhibitor of nitric oxide synthase) prevents IL-1 beta-induced cGMP accumulation.	omega-N-Methylarginine	79-103	interleukin 1 beta	Homo sapiens	164-173
1384465-4	1992	The accumulation of cGMP is dependent on nitric oxide synthase activity, since NG-monomethyl-L-arginine (a competitive inhibitor of nitric oxide synthase) prevents IL-1 beta-induced cGMP accumulation.	Cyclic GMP	182-186	interleukin 1 beta	Homo sapiens	164-173
1384465-5	1992	cGMP formation and nitrite production induced by IL-1 beta pretreatment of islets are also blocked by the protein synthesis inhibitor, cycloheximide.	Cyclic GMP	0-4	interleukin 1 beta	Homo sapiens	49-58
1384465-5	1992	cGMP formation and nitrite production induced by IL-1 beta pretreatment of islets are also blocked by the protein synthesis inhibitor, cycloheximide.	Nitrites	19-26	interleukin 1 beta	Homo sapiens	49-58
1384465-5	1992	cGMP formation and nitrite production induced by IL-1 beta pretreatment of islets are also blocked by the protein synthesis inhibitor, cycloheximide.	Cycloheximide	135-148	interleukin 1 beta	Homo sapiens	49-58
1384465-6	1992	The formation of cGMP does not appear to mediate the inhibitory effects of IL-1 beta on insulin secretion since a concentration of cycloheximide (1 microM) that blocks IL-1 beta-induced inhibition of glucose-stimulated insulin secretion and nitric oxide formation does not prevent cGMP accumulation, thus dissociating the two events.	Cycloheximide	131-144	interleukin 1 beta	Homo sapiens	168-177
1384465-6	1992	The formation of cGMP does not appear to mediate the inhibitory effects of IL-1 beta on insulin secretion since a concentration of cycloheximide (1 microM) that blocks IL-1 beta-induced inhibition of glucose-stimulated insulin secretion and nitric oxide formation does not prevent cGMP accumulation, thus dissociating the two events.	Glucose	200-207	interleukin 1 beta	Homo sapiens	168-177
1384465-8	1992	spectroscopy, IL-1 beta is shown to induce the formation of a g = 2.04 iron-nitrosyl feature in islets which is prevented by cycloheximide, demonstrating the requirement of protein synthesis for IL-1 beta-induced nitric oxide formation.	Iron	71-75	interleukin 1 beta	Homo sapiens	14-23
1384465-8	1992	spectroscopy, IL-1 beta is shown to induce the formation of a g = 2.04 iron-nitrosyl feature in islets which is prevented by cycloheximide, demonstrating the requirement of protein synthesis for IL-1 beta-induced nitric oxide formation.	Iron	71-75	interleukin 1 beta	Homo sapiens	195-204
1384465-8	1992	spectroscopy, IL-1 beta is shown to induce the formation of a g = 2.04 iron-nitrosyl feature in islets which is prevented by cycloheximide, demonstrating the requirement of protein synthesis for IL-1 beta-induced nitric oxide formation.	Cycloheximide	125-138	interleukin 1 beta	Homo sapiens	14-23
1384465-8	1992	spectroscopy, IL-1 beta is shown to induce the formation of a g = 2.04 iron-nitrosyl feature in islets which is prevented by cycloheximide, demonstrating the requirement of protein synthesis for IL-1 beta-induced nitric oxide formation.	Cycloheximide	125-138	interleukin 1 beta	Homo sapiens	195-204
1384465-8	1992	spectroscopy, IL-1 beta is shown to induce the formation of a g = 2.04 iron-nitrosyl feature in islets which is prevented by cycloheximide, demonstrating the requirement of protein synthesis for IL-1 beta-induced nitric oxide formation.	Nitric Oxide	213-225	interleukin 1 beta	Homo sapiens	14-23
1384465-8	1992	spectroscopy, IL-1 beta is shown to induce the formation of a g = 2.04 iron-nitrosyl feature in islets which is prevented by cycloheximide, demonstrating the requirement of protein synthesis for IL-1 beta-induced nitric oxide formation.	Nitric Oxide	213-225	interleukin 1 beta	Homo sapiens	195-204
1384465-9	1992	Iron-nitrosyl complex-formation by islets confirms that IL-1 beta induces the generation of nitric oxide by islets, and provides evidence indicating that nitric oxide mediates destruction of iron-sulphur clusters of iron-containing enzymes.	dinitrosyl iron complex	0-13	interleukin 1 beta	Homo sapiens	56-65
1384465-9	1992	Iron-nitrosyl complex-formation by islets confirms that IL-1 beta induces the generation of nitric oxide by islets, and provides evidence indicating that nitric oxide mediates destruction of iron-sulphur clusters of iron-containing enzymes.	Nitric Oxide	92-104	interleukin 1 beta	Homo sapiens	56-65
1384465-9	1992	Iron-nitrosyl complex-formation by islets confirms that IL-1 beta induces the generation of nitric oxide by islets, and provides evidence indicating that nitric oxide mediates destruction of iron-sulphur clusters of iron-containing enzymes.	Iron	191-195	interleukin 1 beta	Homo sapiens	56-65
1384465-9	1992	Iron-nitrosyl complex-formation by islets confirms that IL-1 beta induces the generation of nitric oxide by islets, and provides evidence indicating that nitric oxide mediates destruction of iron-sulphur clusters of iron-containing enzymes.	Iron	216-220	interleukin 1 beta	Homo sapiens	56-65
1384465-12	1992	Inhibition of islet glucose oxidation appears to be mediated by nitric oxide since both NMMA and cycloheximide prevent IL-1 beta-induced inhibition of glucose oxidation.	Glucose	20-27	interleukin 1 beta	Homo sapiens	119-128
1384465-12	1992	Inhibition of islet glucose oxidation appears to be mediated by nitric oxide since both NMMA and cycloheximide prevent IL-1 beta-induced inhibition of glucose oxidation.	Nitric Oxide	64-76	interleukin 1 beta	Homo sapiens	119-128
1384465-12	1992	Inhibition of islet glucose oxidation appears to be mediated by nitric oxide since both NMMA and cycloheximide prevent IL-1 beta-induced inhibition of glucose oxidation.	N-methylmalonamic acid	88-92	interleukin 1 beta	Homo sapiens	119-128
1384465-12	1992	Inhibition of islet glucose oxidation appears to be mediated by nitric oxide since both NMMA and cycloheximide prevent IL-1 beta-induced inhibition of glucose oxidation.	Cycloheximide	97-110	interleukin 1 beta	Homo sapiens	119-128
1384465-12	1992	Inhibition of islet glucose oxidation appears to be mediated by nitric oxide since both NMMA and cycloheximide prevent IL-1 beta-induced inhibition of glucose oxidation.	Glucose	151-158	interleukin 1 beta	Homo sapiens	119-128
1400875-6	1992	Additionally, treatment of chorion cells with IL-1 beta in combination with actinomycin-D or cycloheximide attenuated the stimulatory action of IL-1 beta on IL-6 production.	Dactinomycin	76-89	interleukin 1 beta	Homo sapiens	144-153
1400875-6	1992	Additionally, treatment of chorion cells with IL-1 beta in combination with actinomycin-D or cycloheximide attenuated the stimulatory action of IL-1 beta on IL-6 production.	Cycloheximide	93-106	interleukin 1 beta	Homo sapiens	144-153
1331350-0	1992	Preventive effects of interleukin 1 beta for ACNU-induced myelosuppression in malignant brain tumors: the experimental and preliminary clinical studies.	Nimustine hydrochloride	45-49	interleukin 1 beta	Homo sapiens	22-40
1522134-6	1992	Treatment of amnion cells stimulated by IL-1 beta with cycloheximide resulted in increased IL-8 production, while incubation of IL-1 beta treated amnion cells with actinomycin D resulted in a concentration-dependent decrease in detectable amounts of IL-8.	Cycloheximide	55-68	interleukin 1 beta	Homo sapiens	40-49
1522134-6	1992	Treatment of amnion cells stimulated by IL-1 beta with cycloheximide resulted in increased IL-8 production, while incubation of IL-1 beta treated amnion cells with actinomycin D resulted in a concentration-dependent decrease in detectable amounts of IL-8.	Dactinomycin	164-177	interleukin 1 beta	Homo sapiens	128-137
1331350-1	1992	The effect of recombinant human interleukin 1 beta (rHuIL-1 beta) on myelosuppression induced by 3-[(4-amino-2-methyl-5-pyrimidynyl)methyl]-1-(2-chloroethyl)-1-nit rosourea hydrochloride (ACNU) was studied.	3-[(4-amino-2-methyl-5-pyrimidynyl)methyl]-1-(2-chloroethyl)-1-nit rosourea hydrochloride	97-186	interleukin 1 beta	Homo sapiens	32-50
1479572-4	1992	This priming effect of 1,25-(OH)2D3 was augmented by the addition of E2 and Te at physiologic concentrations, but not by that of P. E2, P and Te at physiologic concentrations enhanced IL-1 beta production by HL-60 cells that were pretreated with 1,25(OH)2D3 and stimulated by LPS.	Calcitriol	23-35	interleukin 1 beta	Homo sapiens	184-193
1479572-4	1992	This priming effect of 1,25-(OH)2D3 was augmented by the addition of E2 and Te at physiologic concentrations, but not by that of P. E2, P and Te at physiologic concentrations enhanced IL-1 beta production by HL-60 cells that were pretreated with 1,25(OH)2D3 and stimulated by LPS.	Calcitriol	246-257	interleukin 1 beta	Homo sapiens	184-193
1479572-3	1992	Pretreatment of HL-60 cells with 1,25-(OH)2D3 enhanced their ability to produce IL-1 beta in response to subsequent exposure to LPS, although 1,25-(OH)2D3 by itself did not induce IL-1 beta production by HL-60 cells.	Calcitriol	33-45	interleukin 1 beta	Homo sapiens	80-89
1479572-6	1992	These findings suggest that enhancing effects of sex steroids in IL-1 beta production by monocyte/macrophage lineage cells.	Steroids	53-61	interleukin 1 beta	Homo sapiens	65-74
1405754-2	1992	IL-1 stimulated tritiated thymidine (3H-TdR) uptake of AML cells in 8/12 cases, whereas IL-4 enhanced 3H-TdR uptake in 5/12.	Tritiated thymidine	16-35	interleukin 1 beta	Homo sapiens	0-4
1405754-2	1992	IL-1 stimulated tritiated thymidine (3H-TdR) uptake of AML cells in 8/12 cases, whereas IL-4 enhanced 3H-TdR uptake in 5/12.	Tritium	37-39	interleukin 1 beta	Homo sapiens	0-4
1387585-0	1992	Specific inhibition of interleukin 1 beta gene expression by an antisense oligonucleotide: obligatory role of interleukin 1 in the generation of lymphokine-activated killer cells.	Oligonucleotides	74-89	interleukin 1 beta	Homo sapiens	23-41
1526281-2	1992	In ABAE, endotoxin-, IL-1 beta- and TNF alpha-induced tissue factor expression was suppressed by interleukin-4 (IL-4) which also neutralized the pyrogenic effect of endotoxin in HUVEC and monocytes.	abae	3-7	interleukin 1 beta	Homo sapiens	21-30
1330615-8	1992	The carboxyl-terminal tripeptide portion of alpha-MSH may be important for the antagonistic action of alpha-MSH on the anorexia induced by IL-1.	tripeptide K-26	22-32	interleukin 1 beta	Homo sapiens	139-143
1387585-6	1992	However, a synthetic IL-1 beta antisense oligonucleotide, which could specifically inhibit intracellular IL-1 beta protein expression as detected by Western blot, was more effective in reducing LAK killing, but it could not suppress the cytotoxicity generated by exogenous IL-1 plus IL-2.	Oligonucleotides	41-56	interleukin 1 beta	Homo sapiens	21-30
1387585-6	1992	However, a synthetic IL-1 beta antisense oligonucleotide, which could specifically inhibit intracellular IL-1 beta protein expression as detected by Western blot, was more effective in reducing LAK killing, but it could not suppress the cytotoxicity generated by exogenous IL-1 plus IL-2.	Oligonucleotides	41-56	interleukin 1 beta	Homo sapiens	105-114
1525118-3	1992	We studied the effects of continuous administration of recombinant human interleukin-1 beta (rhIL-1 beta) on plasma levels of cholesterol and triglycerides.	Cholesterol	126-137	interleukin 1 beta	Homo sapiens	73-91
1444208-2	1992	A significant amount of IL-1 beta in the culture supernatant of the human PBMC stimulated with agrimoniin was detected with an enzyme-linked immunoadherent assay.	agrimoniin	95-105	interleukin 1 beta	Homo sapiens	24-33
1444208-3	1992	Agrimoniin induced IL-1 beta secretion dose- and time-dependently.	agrimoniin	0-10	interleukin 1 beta	Homo sapiens	19-28
1444189-0	1992	The role of granulocyte-macrophage colony-stimulating factor in induction of monocytic differentiation of HL-60 cells: synergistic interaction with 1 alpha, 25-dihydroxyvitamin D3 and interferon-gamma in inducing interleukin-1 beta.	Calcitriol	148-179	interleukin 1 beta	Homo sapiens	213-231
1417523-5	1992	In situ hybridization, using a synthetic oligonucleotide DNA probe of the IL-6 gene, revealed that most PDL cells expressed IL-6 mRNA in response to IL-1 beta treatment.	Oligonucleotides	41-56	interleukin 1 beta	Homo sapiens	149-158
1525118-3	1992	We studied the effects of continuous administration of recombinant human interleukin-1 beta (rhIL-1 beta) on plasma levels of cholesterol and triglycerides.	Triglycerides	142-155	interleukin 1 beta	Homo sapiens	73-91
1516257-6	1992	After ivermectin treatment, the OvAg-induced production of IL-1 beta and TNF-alpha increased significantly 1 and 14 months after treatment.	ovag	32-36	interleukin 1 beta	Homo sapiens	59-68
1358381-9	1992	Formoterol and salmeterol reduced the secretion of IL-1 beta only at the highest dose (1 x 10(-5) M).	Formoterol Fumarate	0-10	interleukin 1 beta	Homo sapiens	51-60
1420999-0	1992	Regulation of synovial cell growth: basic fibroblast growth factor synergizes with interleukin 1 beta stimulating phospholipase A2 enzyme activity, phospholipase A2 activating protein production and release of prostaglandin E2 by rheumatoid arthritis synovial cells in culture.	Dinoprostone	210-226	interleukin 1 beta	Homo sapiens	83-101
1326572-6	1992	In contrast, after 20 hours of preincubation, stimulated cAMP production of PBMCs was significantly diminished, with 63% by IL-1 (40 U/ml, p less than 0.01), with 36% by IL-2 (100 U/ml, p less than 0.05), with 37% by IFN-gamma (1000 U/ml, p less than 0.05), and with 21% by GM-CSF (100 U/ml, p less than 0.05).	Cyclic AMP	57-61	interleukin 1 beta	Homo sapiens	124-128
1333537-12	1992	However, a phosphorylation event may be involved in the signal transduction mechanism, as treatment with okadaic acid to inhibit protein phosphatase 2a potentiated the induction of NGF mRNA by Il-1 beta.	Okadaic Acid	105-117	interleukin 1 beta	Homo sapiens	193-202
1447600-7	1992	The IL-1 beta detection test proved further to be an important distinguishing parameter as it was 100% positive in patients with viral hepatitis but only 12.5% to 25% positive in patients with VC/TNT-induced liver damage.	Trinitrotoluene	196-199	interleukin 1 beta	Homo sapiens	4-13
1410528-4	1992	EGF, IL-1 beta and TNF-alpha alone caused a dose-dependent increase in PGE2 production, while IL-6, IL-8 and GM-CSF were ineffective over the dose range tested.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	5-14
1410528-5	1992	When cells were preincubated with IL-1 beta or TNF-alpha, there was a dose-dependent potentiation of EGF-induced PGE2 production that was greater than the sum of EGF alone and IL-1 beta or TNF-alpha alone.	Dinoprostone	113-117	interleukin 1 beta	Homo sapiens	34-43
1410528-6	1992	In each case, the minimum dose of IL-1 beta or TNF-alpha which amplified EGF-induced PGE2 production was 0.1 ng/ml (p less than 0.05, Student"s t-test).	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	34-43
1410528-7	1992	These data show that low concentrations of IL-1 beta or TNF-alpha may serve to amplify EGF-mediated PGE2 biosynthesis in amnion-derived cells and suggest that cytokines may modulate EGF function in responsive cells.	Dinoprostone	100-104	interleukin 1 beta	Homo sapiens	43-52
1381520-1	1992	The role of elevated intracellular calcium concentration [Ca2+]i in the LPS-induced activation of interleukin-1 beta (IL-1 beta) production was examined in cells representing different stages of myeloid differentiation (undifferentiated monocytic leukaemia cell line THP-1, THP-1 cells induced to adherent, macrophage-like cells by phorbol ester treatment and normal peripheral blood-derived adherent monocytes).	Calcium	35-42	interleukin 1 beta	Homo sapiens	98-116
1381520-1	1992	The role of elevated intracellular calcium concentration [Ca2+]i in the LPS-induced activation of interleukin-1 beta (IL-1 beta) production was examined in cells representing different stages of myeloid differentiation (undifferentiated monocytic leukaemia cell line THP-1, THP-1 cells induced to adherent, macrophage-like cells by phorbol ester treatment and normal peripheral blood-derived adherent monocytes).	Calcium	35-42	interleukin 1 beta	Homo sapiens	118-127
1381520-3	1992	When these cells were stimulated with LPS in the presence of the calcium ionophore A23187, a clear increase in the IL-1 beta protein production was observed in the undifferentiated THP-1 cells but not in the more differentiated cell types.	Calcium	65-72	interleukin 1 beta	Homo sapiens	115-124
1381520-3	1992	When these cells were stimulated with LPS in the presence of the calcium ionophore A23187, a clear increase in the IL-1 beta protein production was observed in the undifferentiated THP-1 cells but not in the more differentiated cell types.	Calcimycin	83-89	interleukin 1 beta	Homo sapiens	115-124
1358381-9	1992	Formoterol and salmeterol reduced the secretion of IL-1 beta only at the highest dose (1 x 10(-5) M).	Salmeterol Xinafoate	15-25	interleukin 1 beta	Homo sapiens	51-60
1458789-0	1992	Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids.	Fatty Acids, Omega-3	116-147	interleukin 1 beta	Homo sapiens	10-28
1458789-10	1992	We conclude that dietary supplementation with n-3 fatty acids results in significantly reduced plasma IL-1 beta levels in patients with rheumatoid arthritis.	Fatty Acids, Omega-3	46-61	interleukin 1 beta	Homo sapiens	102-111
1522240-11	1992	Cycloheximide was a potent LIF mRNA inducer and dexamethasone inhibited LIF induced by PMA or IL-1 beta.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	94-103
1522240-11	1992	Cycloheximide was a potent LIF mRNA inducer and dexamethasone inhibited LIF induced by PMA or IL-1 beta.	Dexamethasone	48-61	interleukin 1 beta	Homo sapiens	94-103
1387412-0	1992	Human dermal fibroblast interleukin-1 receptor antagonist (IL-1ra) and interleukin-1 beta (IL-1 beta) mRNA and protein are co-stimulated by phorbol ester: implication for a homeostatic mechanism.	Phorbol Esters	140-153	interleukin 1 beta	Homo sapiens	71-89
1387412-0	1992	Human dermal fibroblast interleukin-1 receptor antagonist (IL-1ra) and interleukin-1 beta (IL-1 beta) mRNA and protein are co-stimulated by phorbol ester: implication for a homeostatic mechanism.	Phorbol Esters	140-153	interleukin 1 beta	Homo sapiens	91-100
1387412-8	1992	Similarly, ELISA demonstrated that fibroblast cytoplasmic interleukin-1 receptor antagonist protein and interleukin-1 beta protein were co-stimulated by phorbol ester.	Phorbol Esters	153-166	interleukin 1 beta	Homo sapiens	104-122
1495696-7	1992	RESULTS: Interleukin-1 beta significantly inhibited 3H-thymidine uptake in freshly explanted endometrial stromal cells at all doses in a dose-dependent manner; a 44% inhibition was seen at 2.5 ng/mL IL-1 after 72 hours of incubation.	3h-thymidine	52-64	interleukin 1 beta	Homo sapiens	9-27
1495696-7	1992	RESULTS: Interleukin-1 beta significantly inhibited 3H-thymidine uptake in freshly explanted endometrial stromal cells at all doses in a dose-dependent manner; a 44% inhibition was seen at 2.5 ng/mL IL-1 after 72 hours of incubation.	3h-thymidine	52-64	interleukin 1 beta	Homo sapiens	199-203
1495696-8	1992	In first- and sixth-passage cells, 3H-thymidine uptake was inhibited only at intermediate and high doses of IL-1.	3h-thymidine	35-47	interleukin 1 beta	Homo sapiens	108-112
1438464-8	1992	In view of the interregulatory effects between prostanoids and macrophage cytokines in their production, these findings may indicate that the impaired release of PGI2 during peritonitis has allowed the macrophages to secrete more IL-1 beta after in vitro stimulation with LPS.	Prostaglandins	47-58	interleukin 1 beta	Homo sapiens	230-239
1438464-8	1992	In view of the interregulatory effects between prostanoids and macrophage cytokines in their production, these findings may indicate that the impaired release of PGI2 during peritonitis has allowed the macrophages to secrete more IL-1 beta after in vitro stimulation with LPS.	Epoprostenol	162-166	interleukin 1 beta	Homo sapiens	230-239
1381520-0	1992	The effect of calcium mobilization on LPS-induced IL-1 beta production depends on the differentiation stage of the monocytes/macrophages.	Calcium	14-21	interleukin 1 beta	Homo sapiens	50-59
1330055-1	1992	Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation.	Dinoprostone	95-111	interleukin 1 beta	Homo sapiens	18-36
1358037-7	1992	In the group treated with sulphasalazine there was a progressive and significant decline in serum IL-1 alpha, IL-1 beta, and TNF alpha levels over the six month period (median levels at six months were &lt; 0.1, 0.12, and 0.44 ng/ml respectively).	Sulfasalazine	26-40	interleukin 1 beta	Homo sapiens	110-119
1330055-1	1992	Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation.	Dinoprostone	95-111	interleukin 1 beta	Homo sapiens	38-47
1330055-4	1992	Ionomycin and A23187, two calcium ionophores, synergistically potentiated the stimulatory effect of IL-1 beta on PGE2 formation.	Ionomycin	0-9	interleukin 1 beta	Homo sapiens	100-109
1330055-4	1992	Ionomycin and A23187, two calcium ionophores, synergistically potentiated the stimulatory effect of IL-1 beta on PGE2 formation.	Calcimycin	14-20	interleukin 1 beta	Homo sapiens	100-109
1330055-1	1992	Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation.	Dinoprostone	113-117	interleukin 1 beta	Homo sapiens	18-36
1330055-4	1992	Ionomycin and A23187, two calcium ionophores, synergistically potentiated the stimulatory effect of IL-1 beta on PGE2 formation.	Calcium	26-33	interleukin 1 beta	Homo sapiens	100-109
1330055-1	1992	Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation.	Dinoprostone	113-117	interleukin 1 beta	Homo sapiens	38-47
1330055-4	1992	Ionomycin and A23187, two calcium ionophores, synergistically potentiated the stimulatory effect of IL-1 beta on PGE2 formation.	Dinoprostone	113-117	interleukin 1 beta	Homo sapiens	100-109
1330055-5	1992	Three different phorbol esters known to activate protein kinase C also synergistically potentiated the action of IL-1 beta on PGE2 formation.	Phorbol Esters	16-30	interleukin 1 beta	Homo sapiens	113-122
1330055-1	1992	Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation.	Cyclic AMP	275-285	interleukin 1 beta	Homo sapiens	18-36
1330055-5	1992	Three different phorbol esters known to activate protein kinase C also synergistically potentiated the action of IL-1 beta on PGE2 formation.	Dinoprostone	126-130	interleukin 1 beta	Homo sapiens	113-122
1330055-1	1992	Recombinant human interleukin-1 beta (IL-1 beta) and bradykinin (BK) synergistically stimulate prostaglandin E2 (PGE2) formation in human gingival fibroblasts cultured for 24 h. Neither BK or IL-1 beta per se, nor their combinations, caused any acute stimulation of cellular cyclic AMP accumulation.	Cyclic AMP	275-285	interleukin 1 beta	Homo sapiens	38-47
1330055-7	1992	In IL-1 beta treated cells, the enhancement of PGE2 formation seen after addition of arachidonic acid, was synergistically upregulated by IL-1 beta.	Dinoprostone	47-51	interleukin 1 beta	Homo sapiens	3-12
1330055-7	1992	In IL-1 beta treated cells, the enhancement of PGE2 formation seen after addition of arachidonic acid, was synergistically upregulated by IL-1 beta.	Dinoprostone	47-51	interleukin 1 beta	Homo sapiens	138-147
1639516-3	1992	In contrast, the secretion of IL-1 beta was blocked by a cyclic AMP- and cyclic GMP-dependent kinase inhibitor (HA1004) as well as by H7 and genistein.	Cyclic AMP	57-67	interleukin 1 beta	Homo sapiens	30-39
1330055-7	1992	In IL-1 beta treated cells, the enhancement of PGE2 formation seen after addition of arachidonic acid, was synergistically upregulated by IL-1 beta.	Arachidonic Acid	85-101	interleukin 1 beta	Homo sapiens	3-12
1330055-7	1992	In IL-1 beta treated cells, the enhancement of PGE2 formation seen after addition of arachidonic acid, was synergistically upregulated by IL-1 beta.	Arachidonic Acid	85-101	interleukin 1 beta	Homo sapiens	138-147
1525675-0	1992	Interleukin-1 beta depresses calcium currents in CA1 hippocampal neurons at pathophysiological concentrations.	Calcium	29-36	interleukin 1 beta	Homo sapiens	0-18
1525675-2	1992	In the present study, we examined the interaction between recombinant human interleukin-1 beta (rhIL-1 beta) and the voltage-dependent calcium (Ca2+) current using the whole-cell patch clamp technique.	Calcium	135-142	interleukin 1 beta	Homo sapiens	76-94
1322806-4	1992	IL-1 alpha and IL-1 beta stimulated a time (0-72 hr) and concentration-dependent (0.01-10 ng/ml) production of collagenase, gelatinase, caseinase, and prostaglandin E2 (PGE2) in BNC monolayer cultures.	Dinoprostone	151-167	interleukin 1 beta	Homo sapiens	15-24
1322806-4	1992	IL-1 alpha and IL-1 beta stimulated a time (0-72 hr) and concentration-dependent (0.01-10 ng/ml) production of collagenase, gelatinase, caseinase, and prostaglandin E2 (PGE2) in BNC monolayer cultures.	Dinoprostone	169-173	interleukin 1 beta	Homo sapiens	15-24
1426065-3	1992	The combination of cycloheximide and recombinant interleukin-1 caused a 14-fold enhancement of interleukin-1 alpha and interleukin-1 beta mRNA expression above that observed after cells were stimulated with interleukin-1 alone.	Cycloheximide	19-32	interleukin 1 beta	Homo sapiens	119-137
1639516-3	1992	In contrast, the secretion of IL-1 beta was blocked by a cyclic AMP- and cyclic GMP-dependent kinase inhibitor (HA1004) as well as by H7 and genistein.	N-(2-guanidinoethyl)-5-isoquinolinesulfonamide	112-118	interleukin 1 beta	Homo sapiens	30-39
1639516-3	1992	In contrast, the secretion of IL-1 beta was blocked by a cyclic AMP- and cyclic GMP-dependent kinase inhibitor (HA1004) as well as by H7 and genistein.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	134-136	interleukin 1 beta	Homo sapiens	30-39
1322431-4	1992	Both IL-1 alpha and beta inhibited [3H] thymidine uptake into NPA cell DNA in a dose- and time-dependent manner at concentrations ranging from 5 x 10(2) to 10(5) U/L; 10(5) U/L of IL-1 suppressed DNA synthesis by more than 40% of control.	Tritium	36-38	interleukin 1 beta	Homo sapiens	5-9
1365641-11	1992	Dexamethasone blunted the induction of MCP-1 gene expression by IL-1 and by activators of protein kinase A as well as protein kinase C signal transduction pathways.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	64-68
1639516-3	1992	In contrast, the secretion of IL-1 beta was blocked by a cyclic AMP- and cyclic GMP-dependent kinase inhibitor (HA1004) as well as by H7 and genistein.	Genistein	141-150	interleukin 1 beta	Homo sapiens	30-39
1365641-12	1992	In contrast, retinoic acid strongly increased phorbol myristate acetate-induced MCP-1 expression and potentiated the effects of IL-1 and LPS.	Tretinoin	13-26	interleukin 1 beta	Homo sapiens	128-140
1322431-4	1992	Both IL-1 alpha and beta inhibited [3H] thymidine uptake into NPA cell DNA in a dose- and time-dependent manner at concentrations ranging from 5 x 10(2) to 10(5) U/L; 10(5) U/L of IL-1 suppressed DNA synthesis by more than 40% of control.	Thymidine	40-49	interleukin 1 beta	Homo sapiens	5-9
1619653-0	1992	A 500 ps molecular dynamics simulation study of interleukin-1 beta in water.	Water	70-75	interleukin 1 beta	Homo sapiens	48-66
1639861-4	1992	Two PKC inhibitors, H7 and staurosporine (SS), abrogated IL-1 beta induced TNF-alpha expression in a dose-dependent fashion.	Staurosporine	27-40	interleukin 1 beta	Homo sapiens	57-66
1639861-4	1992	Two PKC inhibitors, H7 and staurosporine (SS), abrogated IL-1 beta induced TNF-alpha expression in a dose-dependent fashion.	Staurosporine	42-44	interleukin 1 beta	Homo sapiens	57-66
1282159-11	1992	Interleukin-1 beta induced a time- and concentration-dependent production of nitrite.	Nitrites	77-84	interleukin 1 beta	Homo sapiens	0-18
1282159-12	1992	Cycloheximide and nitro-L-arginine inhibited the relaxations and the production of nitrite evoked by interleukin-1 beta-treated cells.	Cycloheximide	0-13	interleukin 1 beta	Homo sapiens	101-119
1282159-12	1992	Cycloheximide and nitro-L-arginine inhibited the relaxations and the production of nitrite evoked by interleukin-1 beta-treated cells.	Nitroarginine	18-34	interleukin 1 beta	Homo sapiens	101-119
1282159-12	1992	Cycloheximide and nitro-L-arginine inhibited the relaxations and the production of nitrite evoked by interleukin-1 beta-treated cells.	Nitrites	83-90	interleukin 1 beta	Homo sapiens	101-119
1282159-14	1992	Transforming growth factor-beta 1 reduced the interleukin-1 beta-dependent generation of nitrite by cultured smooth muscle cells and relaxation of contracted bioassay tissues.	Nitrites	89-96	interleukin 1 beta	Homo sapiens	46-64
1322666-4	1992	DDTC treatment also increased interleukin-alpha (IL-1 alpha), IL-1 beta, and tumor necrosis factor (TNF) expression in these cells.	Ditiocarb	0-4	interleukin 1 beta	Homo sapiens	62-71
1322666-9	1992	These data suggest that the myeloprotective effects of DDTC may be mediated, at least in part, by the induction of TNF, IL-1 alpha, and IL-1 beta.	Ditiocarb	55-59	interleukin 1 beta	Homo sapiens	136-145
1352775-4	1992	In contrast to what occurs in dermal fibroblasts, IL-1 beta (5-20 units/ml) preferentially inhibited procollagen production as measured by [3H]proline incorporation.	Tritium	140-142	interleukin 1 beta	Homo sapiens	50-59
1352775-4	1992	In contrast to what occurs in dermal fibroblasts, IL-1 beta (5-20 units/ml) preferentially inhibited procollagen production as measured by [3H]proline incorporation.	Proline	143-150	interleukin 1 beta	Homo sapiens	50-59
1380063-11	1992	dLPS and its synthetic lipid A counterpart, LA-14-PP (also known as lipid Ia, lipid IVa, or compound 406) strongly inhibited LPS-induced NF-kappa B and IL-1 beta, yet neither antagonist inhibited the uptake of LPS via CD14.	la-14-pp	44-52	interleukin 1 beta	Homo sapiens	152-161
1386253-9	1992	Collapse of beta-strand 1 into a hydrated space between strands 1, 2, and 4 could structurally alter a cleft in IL-1 beta that contains a cluster of highly conserved amino acids, including a key aspartic acid residue [Ju et al.	Aspartic Acid	195-208	interleukin 1 beta	Homo sapiens	112-121
1629217-0	1992	Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid.	9-hydroxyoctadecadienoic acid	103-132	interleukin 1 beta	Homo sapiens	13-31
1629217-7	1992	When tested for activity in macrophage culture (3 x 10(6) cells/culture), it was found that 9-HODE and 13-HODE (final concentration 33 microM) induced the release of 122 and 43 pg of IL-1 beta/culture, respectively, whereas untreated cells released only 4 pg of IL-1 beta/culture.	9-hydroxy-10,12-octadecadienoic acid	92-98	interleukin 1 beta	Homo sapiens	183-192
1629217-7	1992	When tested for activity in macrophage culture (3 x 10(6) cells/culture), it was found that 9-HODE and 13-HODE (final concentration 33 microM) induced the release of 122 and 43 pg of IL-1 beta/culture, respectively, whereas untreated cells released only 4 pg of IL-1 beta/culture.	9-hydroxy-10,12-octadecadienoic acid	92-98	interleukin 1 beta	Homo sapiens	262-271
1629217-7	1992	When tested for activity in macrophage culture (3 x 10(6) cells/culture), it was found that 9-HODE and 13-HODE (final concentration 33 microM) induced the release of 122 and 43 pg of IL-1 beta/culture, respectively, whereas untreated cells released only 4 pg of IL-1 beta/culture.	Coriolic acid	103-110	interleukin 1 beta	Homo sapiens	183-192
1629217-7	1992	When tested for activity in macrophage culture (3 x 10(6) cells/culture), it was found that 9-HODE and 13-HODE (final concentration 33 microM) induced the release of 122 and 43 pg of IL-1 beta/culture, respectively, whereas untreated cells released only 4 pg of IL-1 beta/culture.	Coriolic acid	103-110	interleukin 1 beta	Homo sapiens	262-271
1629217-8	1992	Incubation of macrophages with cholesteryl-9-HODE also induced IL-1 beta release; however, the degree of induction of IL-1 beta release by 9-HODE or its cholesteryl ester relative to modified LDL suggests that other components in oxidized LDL may also contribute to IL-1 beta induction.	cholesteryl-9-hode	31-49	interleukin 1 beta	Homo sapiens	63-72
1629217-8	1992	Incubation of macrophages with cholesteryl-9-HODE also induced IL-1 beta release; however, the degree of induction of IL-1 beta release by 9-HODE or its cholesteryl ester relative to modified LDL suggests that other components in oxidized LDL may also contribute to IL-1 beta induction.	9-hydroxy-10,12-octadecadienoic acid	43-49	interleukin 1 beta	Homo sapiens	63-72
1629217-10	1992	A 1.5- to 6-fold increase in the level of IL-1 beta mRNA was detected as little as 3-h post-9-HODE treatment.	9-hydroxy-10,12-octadecadienoic acid	92-98	interleukin 1 beta	Homo sapiens	42-51
1629217-11	1992	The induction of IL-1 beta release from human monocyte-derived macrophages by 9-HODE and cholesteryl-9-HODE suggests a role for modified LDL, and its associated linoleate oxidation products, in vascular smooth muscle cell proliferation.	9-hydroxy-10,12-octadecadienoic acid	78-84	interleukin 1 beta	Homo sapiens	17-26
1629217-11	1992	The induction of IL-1 beta release from human monocyte-derived macrophages by 9-HODE and cholesteryl-9-HODE suggests a role for modified LDL, and its associated linoleate oxidation products, in vascular smooth muscle cell proliferation.	cholesteryl-9-hode	89-107	interleukin 1 beta	Homo sapiens	17-26
1629217-11	1992	The induction of IL-1 beta release from human monocyte-derived macrophages by 9-HODE and cholesteryl-9-HODE suggests a role for modified LDL, and its associated linoleate oxidation products, in vascular smooth muscle cell proliferation.	Linoleic Acid	161-170	interleukin 1 beta	Homo sapiens	17-26
1619653-2	1992	We report the results of a 500 ps molecular dynamics simulation of the cytokine interleukin-1 beta, a protein of 153 amino acids, immersed in a sphere of 3783 bulk water molecules with a radius of 33 A.	Water	164-169	interleukin 1 beta	Homo sapiens	80-98
1353306-3	1992	HTEC monolayers also exhibited no significant basal ICAM-1 expression but, in contrast to HUVEC monolayers, had marked increases in ICAM-1 expression and ICAM-1-dependent PMN adherence only after incubation with IFN-gamma (and not after IL-1 beta or TNF-alpha) treatment.	htec	0-4	interleukin 1 beta	Homo sapiens	237-246
1385767-6	1992	Gold-salt treatment led to a slightly delayed and enhanced secretion of TNF-alpha and IL-1 beta, an enhanced secretion of IL-2 and a restored secretion of IFN-gamma.	gold-salt	0-9	interleukin 1 beta	Homo sapiens	86-95
1504741-4	1992	IL-1 alpha (1.5-6.0 ng ml-1) and IL-1 beta (30-300 pg ml-1), dose-dependently, stimulated PGE2 formation, in 24 h cultures, with IL-beta being the most potent agonist.	Dinoprostone	90-94	interleukin 1 beta	Homo sapiens	33-42
1504741-6	1992	PHT (2.5-20 micrograms ml-1) did not induce PGE2 formation itself but potentiated IL-1 alpha- and IL-1 beta-induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentrations of both IL-1 and PHT.	Dinoprostone	116-120	interleukin 1 beta	Homo sapiens	98-107
1504741-6	1992	PHT (2.5-20 micrograms ml-1) did not induce PGE2 formation itself but potentiated IL-1 alpha- and IL-1 beta-induced PGE2 formation in the gingival fibroblasts in a manner dependent on the concentrations of both IL-1 and PHT.	Dinoprostone	116-120	interleukin 1 beta	Homo sapiens	82-86
1504741-8	1992	IL-1 beta (0.1-1.0 ng ml-1) induced release of [3H]-arachidonic acid ([3H]-AA) from prelabelled fibroblasts that was potentiated by PHT (20 micrograms ml-1).	Tritium	48-50	interleukin 1 beta	Homo sapiens	0-9
1504741-8	1992	IL-1 beta (0.1-1.0 ng ml-1) induced release of [3H]-arachidonic acid ([3H]-AA) from prelabelled fibroblasts that was potentiated by PHT (20 micrograms ml-1).	Arachidonic Acid	52-68	interleukin 1 beta	Homo sapiens	0-9
1504741-8	1992	IL-1 beta (0.1-1.0 ng ml-1) induced release of [3H]-arachidonic acid ([3H]-AA) from prelabelled fibroblasts that was potentiated by PHT (20 micrograms ml-1).	Tritium	71-73	interleukin 1 beta	Homo sapiens	0-9
1504741-8	1992	IL-1 beta (0.1-1.0 ng ml-1) induced release of [3H]-arachidonic acid ([3H]-AA) from prelabelled fibroblasts that was potentiated by PHT (20 micrograms ml-1).	Phenytoin	132-135	interleukin 1 beta	Homo sapiens	0-9
1504741-14	1992	The results indicate that treatment with PHT results in upregulation of prostaglandin biosynthesis in gingival fibroblasts challenged with IL-1 or TNF alpha, at least partly due to enhanced level of phospholipase A2 activity.	Phenytoin	41-44	interleukin 1 beta	Homo sapiens	139-143
1504741-14	1992	The results indicate that treatment with PHT results in upregulation of prostaglandin biosynthesis in gingival fibroblasts challenged with IL-1 or TNF alpha, at least partly due to enhanced level of phospholipase A2 activity.	Prostaglandins	72-85	interleukin 1 beta	Homo sapiens	139-143
1321178-7	1992	Nedocromil sodium reduced the IL-1-induced release of IL-8 in a dose-dependent manner, but concentrations of the compounds, up to 10(-5) mol/L, did not affect the constitutive production of this cytokine.	Nedocromil	0-17	interleukin 1 beta	Homo sapiens	30-34
1421015-8	1992	Recombinant IL-1 beta induced a very low level of TNF alpha production in PMA-treated cells.	Tetradecanoylphorbol Acetate	74-77	interleukin 1 beta	Homo sapiens	12-21
1607370-2	1992	Monocytes/macrophages incubated on biomedical polymers with or without protein preadsorption produce variable levels of IL-1-B, IL-6, and TNF-A dependent on the polymer and adsorbed protein.	Polymers	46-54	interleukin 1 beta	Homo sapiens	120-126
1641502-0	1992	Interleukin-1 beta stimulates decidual stromal cell cyclo-oxygenase enzyme and prostaglandin production.	Prostaglandins	79-92	interleukin 1 beta	Homo sapiens	0-18
1501156-3	1992	In fibroblasts, derived after 9 months of PHT therapy, IL-1 alpha, IL-1 beta and TNF alpha induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy.	Phenytoin	42-45	interleukin 1 beta	Homo sapiens	67-76
1501156-3	1992	In fibroblasts, derived after 9 months of PHT therapy, IL-1 alpha, IL-1 beta and TNF alpha induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy.	Dinoprostone	135-139	interleukin 1 beta	Homo sapiens	67-76
1501156-3	1992	In fibroblasts, derived after 9 months of PHT therapy, IL-1 alpha, IL-1 beta and TNF alpha induced a significantly higher formation of PGE2 compared to that in fibroblasts derived before PHT therapy.	Phenytoin	187-190	interleukin 1 beta	Homo sapiens	67-76
1501156-4	1992	IL-1 beta induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy.	3h-arachidonic acid	57-76	interleukin 1 beta	Homo sapiens	0-9
1501156-4	1992	IL-1 beta induced a significantly higher release also of 3H-arachidonic acid (3H-AA) from prelabelled PHT fibroblasts compared to that in prelabelled gingival fibroblasts isolated before the drug therapy.	3h-aa	78-83	interleukin 1 beta	Homo sapiens	0-9
1596574-0	1992	Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation.	Pentoxifylline	148-162	interleukin 1 beta	Homo sapiens	58-76
1596574-0	1992	Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation.	Pentoxifylline	148-162	interleukin 1 beta	Homo sapiens	78-87
1596574-0	1992	Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation.	Dexamethasone	167-180	interleukin 1 beta	Homo sapiens	58-76
1596574-0	1992	Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation.	Dexamethasone	167-180	interleukin 1 beta	Homo sapiens	78-87
1596574-0	1992	Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation.	acivicin	198-206	interleukin 1 beta	Homo sapiens	78-87
1596574-0	1992	Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation.	acivicin	260-268	interleukin 1 beta	Homo sapiens	78-87
1596574-11	1992	DEX and PTX reduced the acivicin-induced increases in TNF-alpha and IL-1 beta mRNA expression, but they had little or no effect on the acivicin-induced decreases in expression of mRNA for c-myc and c-myb.	Pentoxifylline	8-11	interleukin 1 beta	Homo sapiens	68-77
1596574-11	1992	DEX and PTX reduced the acivicin-induced increases in TNF-alpha and IL-1 beta mRNA expression, but they had little or no effect on the acivicin-induced decreases in expression of mRNA for c-myc and c-myb.	acivicin	24-32	interleukin 1 beta	Homo sapiens	68-77
1596574-12	1992	Thus, DEX and PTX effectively block the acivicin-induced expression of TNF-alpha and IL-1 beta, but they have little influence on the acivicin-induced differentiation process.	Dexamethasone	6-9	interleukin 1 beta	Homo sapiens	85-94
1596574-12	1992	Thus, DEX and PTX effectively block the acivicin-induced expression of TNF-alpha and IL-1 beta, but they have little influence on the acivicin-induced differentiation process.	Pentoxifylline	14-17	interleukin 1 beta	Homo sapiens	85-94
1596574-12	1992	Thus, DEX and PTX effectively block the acivicin-induced expression of TNF-alpha and IL-1 beta, but they have little influence on the acivicin-induced differentiation process.	acivicin	40-48	interleukin 1 beta	Homo sapiens	85-94
1385162-2	1992	TGF-beta 1, PDGFAB and PDGFBB but not PDGFAA inhibited in a concentration-dependent manner the production of nitrite, an oxidation product of nitric oxide, evoked by interleukin-1 beta.	Nitrites	109-116	interleukin 1 beta	Homo sapiens	166-184
1385162-2	1992	TGF-beta 1, PDGFAB and PDGFBB but not PDGFAA inhibited in a concentration-dependent manner the production of nitrite, an oxidation product of nitric oxide, evoked by interleukin-1 beta.	Nitric Oxide	142-154	interleukin 1 beta	Homo sapiens	166-184
1385162-4	1992	The addition of interleukin-1 beta-treated smooth muscle cells to suspensions of indomethacin-treated human washed platelets inhibited the aggregation evoked by thrombin whereas no effect was observed with untreated cells.	Indomethacin	81-93	interleukin 1 beta	Homo sapiens	16-34
1596574-1	1992	We have previously noted that the glutamine antagonist acivicin (alpha S,5S-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) induces monocytoid differentiation of freshly isolated human myeloid leukemia cells and cells of the myeloid leukemia cell line HL-60, and that the differentiation is accompanied by increases in expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta).	Glutamine	34-43	interleukin 1 beta	Homo sapiens	386-404
1596574-1	1992	We have previously noted that the glutamine antagonist acivicin (alpha S,5S-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) induces monocytoid differentiation of freshly isolated human myeloid leukemia cells and cells of the myeloid leukemia cell line HL-60, and that the differentiation is accompanied by increases in expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta).	Glutamine	34-43	interleukin 1 beta	Homo sapiens	406-415
1596574-1	1992	We have previously noted that the glutamine antagonist acivicin (alpha S,5S-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) induces monocytoid differentiation of freshly isolated human myeloid leukemia cells and cells of the myeloid leukemia cell line HL-60, and that the differentiation is accompanied by increases in expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta).	acivicin	55-63	interleukin 1 beta	Homo sapiens	386-404
1596574-1	1992	We have previously noted that the glutamine antagonist acivicin (alpha S,5S-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) induces monocytoid differentiation of freshly isolated human myeloid leukemia cells and cells of the myeloid leukemia cell line HL-60, and that the differentiation is accompanied by increases in expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta).	acivicin	55-63	interleukin 1 beta	Homo sapiens	406-415
1596574-1	1992	We have previously noted that the glutamine antagonist acivicin (alpha S,5S-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) induces monocytoid differentiation of freshly isolated human myeloid leukemia cells and cells of the myeloid leukemia cell line HL-60, and that the differentiation is accompanied by increases in expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta).	acivicin	65-131	interleukin 1 beta	Homo sapiens	386-404
1596574-1	1992	We have previously noted that the glutamine antagonist acivicin (alpha S,5S-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) induces monocytoid differentiation of freshly isolated human myeloid leukemia cells and cells of the myeloid leukemia cell line HL-60, and that the differentiation is accompanied by increases in expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta).	acivicin	65-131	interleukin 1 beta	Homo sapiens	406-415
1596574-2	1992	Because we also showed that TNF-alpha and IL-1 beta can act synergistically to cause monocytoid differentiation of HL-60 cells, we hypothesized that acivicin-induced TNF-alpha and IL-1 beta, in an autocrine manner, caused the differentiation.	acivicin	149-157	interleukin 1 beta	Homo sapiens	42-51
1596574-2	1992	Because we also showed that TNF-alpha and IL-1 beta can act synergistically to cause monocytoid differentiation of HL-60 cells, we hypothesized that acivicin-induced TNF-alpha and IL-1 beta, in an autocrine manner, caused the differentiation.	acivicin	149-157	interleukin 1 beta	Homo sapiens	180-189
1596574-3	1992	The purpose of the present study was to determine the causal roles of TNF-alpha and IL-1 beta in the acivicin-induced differentiation of HL-60 cells by the use of dexamethasone (DEX) and pentoxifylline (PTX), two drugs that effectively inhibit expression of TNF-alpha and IL-1 beta.	acivicin	101-109	interleukin 1 beta	Homo sapiens	84-93
1596574-3	1992	The purpose of the present study was to determine the causal roles of TNF-alpha and IL-1 beta in the acivicin-induced differentiation of HL-60 cells by the use of dexamethasone (DEX) and pentoxifylline (PTX), two drugs that effectively inhibit expression of TNF-alpha and IL-1 beta.	acivicin	101-109	interleukin 1 beta	Homo sapiens	272-281
1596574-5	1992	Acivicin treatment also caused the cells to have diminished steady-state expression of messenger RNA (mRNA) for c-myc and c-myb, and increased expression of mRNA for TNF-alpha and IL-1 beta.	acivicin	0-8	interleukin 1 beta	Homo sapiens	180-189
1596574-11	1992	DEX and PTX reduced the acivicin-induced increases in TNF-alpha and IL-1 beta mRNA expression, but they had little or no effect on the acivicin-induced decreases in expression of mRNA for c-myc and c-myb.	Dexamethasone	0-3	interleukin 1 beta	Homo sapiens	68-77
1641502-1	1992	The cytokine interleukin-1 (IL-1 beta) increased prostaglandin production by decidual stromal cells in culture in a time and dose dependent manner.	Prostaglandins	49-62	interleukin 1 beta	Homo sapiens	28-37
1641502-5	1992	A pre-incubation period of 72 hours was found to be necessary to observe the stimulatory effect of IL-1 beta on prostaglandin production, but this did not seem to be due to any change in the sensitivity of the cells to IL-1 beta; the increase in the number of cyclo-oxygenase positive cells was the same if IL-1 beta was added on day 1, day 2 or day 3 of culture, even though prostaglandin production was not stimulated on day 1 or day 2.	Prostaglandins	112-125	interleukin 1 beta	Homo sapiens	99-108
1641502-5	1992	A pre-incubation period of 72 hours was found to be necessary to observe the stimulatory effect of IL-1 beta on prostaglandin production, but this did not seem to be due to any change in the sensitivity of the cells to IL-1 beta; the increase in the number of cyclo-oxygenase positive cells was the same if IL-1 beta was added on day 1, day 2 or day 3 of culture, even though prostaglandin production was not stimulated on day 1 or day 2.	Prostaglandins	376-389	interleukin 1 beta	Homo sapiens	99-108
1597474-8	1992	We found that interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) upregulated PA activity in A549 human pulmonary epithelial cells.	Protactinium	101-103	interleukin 1 beta	Homo sapiens	14-32
1597474-8	1992	We found that interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) upregulated PA activity in A549 human pulmonary epithelial cells.	Protactinium	101-103	interleukin 1 beta	Homo sapiens	34-43
24193026-4	1992	In the IL-1 treated group, a reduction in flux was observed for only three AA, alanine, phenylalanine and serine.	Alanine	79-86	interleukin 1 beta	Homo sapiens	7-11
1591007-4	1992	In this study, we examine the role of amiloride for the regulation of AM-derived interleukin (IL)-8, tumor necrosis factor (TNF), IL-6, and IL-1 beta.	Amiloride	38-47	interleukin 1 beta	Homo sapiens	140-149
1591007-7	1992	Furthermore, the suppressive effect of amiloride appeared to be at the level of mRNA for IL-8, TNF, IL-1 beta, and IL-6, whereas steady-state levels of beta-actin mRNA remained unaltered.	Amiloride	39-48	interleukin 1 beta	Homo sapiens	100-109
1317194-6	1992	In the presence of pIE1+2, there was an approximate 15-fold increase in CAT activity compared with the control, pLink760, in cells with CAT plasmids containing the -1097 to +14 IL-1 sequence.	Tetrahydrocortisone	3-6	interleukin 1 beta	Homo sapiens	177-181
1621837-9	1992	In cells cultured in multiwell plates, interleukin-1 beta evoked a time- and concentration-dependent accumulation of nitrite in the extracellular medium that was inhibited dose dependently by transforming growth factor-beta 1.	Nitrites	117-124	interleukin 1 beta	Homo sapiens	39-57
24193026-4	1992	In the IL-1 treated group, a reduction in flux was observed for only three AA, alanine, phenylalanine and serine.	Phenylalanine	88-101	interleukin 1 beta	Homo sapiens	7-11
24193026-4	1992	In the IL-1 treated group, a reduction in flux was observed for only three AA, alanine, phenylalanine and serine.	Serine	106-112	interleukin 1 beta	Homo sapiens	7-11
24193026-5	1992	Glucose and urea production in the IL-1-treated group was slightly but not-significantly lower than in the controls.rhIL-1beta thus has only minor direct effects on AA flux and gluconeogenesis in the liver and cannot therefore be held responsible for the increase in hepatic amino acid uptake during stress.	Glucose	0-7	interleukin 1 beta	Homo sapiens	35-39
24193026-5	1992	Glucose and urea production in the IL-1-treated group was slightly but not-significantly lower than in the controls.rhIL-1beta thus has only minor direct effects on AA flux and gluconeogenesis in the liver and cannot therefore be held responsible for the increase in hepatic amino acid uptake during stress.	Urea	12-16	interleukin 1 beta	Homo sapiens	35-39
1317386-0	1992	Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3",5"-monophosphate-independent signal transduction pathway.	Cyclic AMP	159-188	interleukin 1 beta	Homo sapiens	15-19
1623646-5	1992	AECA seem to be directed against determinants consitutively expressed on the endothelial surface since the activation of endothelial cells by interleukin-1 beta or interferon-gamma affects neither the antibody binding nor their ability to mediate 51Cr release in the presence of PBM.	pbm	279-282	interleukin 1 beta	Homo sapiens	142-160
1627264-5	1992	It was found that recombinant human IL-1 beta elicited a dose-dependent luminol-enhanced chemiluminescence response in isolated human PMN leukocytes in the dose range 8.8 x 10(-11)-8.8 x 10(-8) M. The effect could be blocked by prior treatment with the IL-1 receptor antagonist, indicating a direct effect on the specific IL-1 receptor.	Luminol	72-79	interleukin 1 beta	Homo sapiens	36-45
1404130-2	1992	We investigated the effects of an NSAID, flurbiprofen, on production of the cytokines tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL-1 beta) and interleukin 6 (IL-6) by human peripheral blood monocytes and by the human cell lines U-937 and THP-1.	Flurbiprofen	41-53	interleukin 1 beta	Homo sapiens	127-145
1404130-5	1992	Flurbiprofen caused moderate inhibition of IL-1 beta and TNF alpha production by stimulated monocytes, but did not affect IL-6 production.	Flurbiprofen	0-12	interleukin 1 beta	Homo sapiens	43-52
1404130-6	1992	In contrast, flurbiprofen completely abolished IL-6 production by both cell lines and substantially inhibited IL-1 beta and TNF alpha production.	Flurbiprofen	13-25	interleukin 1 beta	Homo sapiens	110-119
1386466-1	1992	Intracerebroventricular (ICV) microinfusion of recombinant human interleukin-1 beta (rhIL-1 beta, 1.0 ng/rat) suppressed the short-term (2 h) food and water intakes in rats.	Water	151-156	interleukin 1 beta	Homo sapiens	65-83
1592120-0	1992	IL-1 beta, a strong mediator for glucose uptake by rheumatoid and non-rheumatoid cultured human synoviocytes.	Glucose	33-40	interleukin 1 beta	Homo sapiens	0-9
1592120-1	1992	Higher basal 2-deoxy-D-glucose uptake in rheumatoid synovial cells than in non-rheumatoid synovial cells, was found to be associated with an increased interleukin-1 beta (IL-1 beta) secretion (respectively 850 +/- 238 vs. 8.3 +/- 2.4 pg/24 h/10(5) cells, mean +/- S.E.M.).	Deoxyglucose	13-30	interleukin 1 beta	Homo sapiens	151-169
1592120-1	1992	Higher basal 2-deoxy-D-glucose uptake in rheumatoid synovial cells than in non-rheumatoid synovial cells, was found to be associated with an increased interleukin-1 beta (IL-1 beta) secretion (respectively 850 +/- 238 vs. 8.3 +/- 2.4 pg/24 h/10(5) cells, mean +/- S.E.M.).	Deoxyglucose	13-30	interleukin 1 beta	Homo sapiens	171-180
1592120-2	1992	When exogenous human recombinant IL-1 beta was added to cultures, a marked stimulation of 2-deoxy-D-glucose uptake was performed by both human synovial cultured cells, in a time-dependent and dose-dependent manner (IL-1 beta 0-100 ng/ml).	Deoxyglucose	90-107	interleukin 1 beta	Homo sapiens	33-42
1592120-2	1992	When exogenous human recombinant IL-1 beta was added to cultures, a marked stimulation of 2-deoxy-D-glucose uptake was performed by both human synovial cultured cells, in a time-dependent and dose-dependent manner (IL-1 beta 0-100 ng/ml).	Deoxyglucose	90-107	interleukin 1 beta	Homo sapiens	215-224
1592120-5	1992	IL-1 beta increased significantly the Vmax for 2-deoxy-D-glucose uptake by synovial cells, with no change in the Km.	Deoxyglucose	47-64	interleukin 1 beta	Homo sapiens	0-9
1592120-7	1992	IL-1 beta possesses an important effect on glucose homeostasis in synovial cells, which could be indirect and/or regulated by the presence of natural inhibitors.	Glucose	43-50	interleukin 1 beta	Homo sapiens	0-9
1534816-7	1992	Treatment of cell cultures with forskolin (25 microM) induced IL-1 beta transcripts in granulosa but not theca cells.	Colforsin	32-41	interleukin 1 beta	Homo sapiens	62-71
1321354-3	1992	This stimulatory action of IL-1 on ACTH was significantly attenuated by a short in vitro dexamethasone pretreatment.	Dexamethasone	89-102	interleukin 1 beta	Homo sapiens	27-31
1510423-6	1992	AB-induced IL-1 beta expression was suppressed by hydrocortisone (HC), pentoxifylline, and an investigational theobromine, A81-3138, in a linear, dose-related manner.	Hydrocortisone	50-64	interleukin 1 beta	Homo sapiens	11-20
1510423-6	1992	AB-induced IL-1 beta expression was suppressed by hydrocortisone (HC), pentoxifylline, and an investigational theobromine, A81-3138, in a linear, dose-related manner.	Pentoxifylline	71-85	interleukin 1 beta	Homo sapiens	11-20
1510423-6	1992	AB-induced IL-1 beta expression was suppressed by hydrocortisone (HC), pentoxifylline, and an investigational theobromine, A81-3138, in a linear, dose-related manner.	Theobromine	110-121	interleukin 1 beta	Homo sapiens	11-20
1510423-9	1992	Pentoxifylline and A81-3138 may also be effective in modulating IL-1 beta expression by mononuclear cells at concentrations achievable in serum.	Pentoxifylline	0-14	interleukin 1 beta	Homo sapiens	64-73
1627264-6	1992	Preincubation by IL-1 beta enhanced the effect of a secondary challenge with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe by 30-40%.	Tetradecanoylphorbol Acetate	77-108	interleukin 1 beta	Homo sapiens	17-26
1533323-8	1992	However, this phenomenon was not specific for LPS; 1 microgram/mL IL-1ra inhibited IL-1 beta synthesized in response to human recombinant IL-2 by 44% (P less than .001), toxic shock syndrome toxin-1 by 26% (P less than .05), and phorbol 12-myristate 13-acetate by 76% (P less than .001).	Tetradecanoylphorbol Acetate	229-260	interleukin 1 beta	Homo sapiens	83-92
1627264-6	1992	Preincubation by IL-1 beta enhanced the effect of a secondary challenge with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe by 30-40%.	N-Formylmethionine Leucyl-Phenylalanine	112-130	interleukin 1 beta	Homo sapiens	17-26
1498252-4	1992	Treatment of the cells with the systemic hormones 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] (10(-8) M) and parathyroid hormone (10(-7) M) induced an increase in TGF-beta mRNA but failed to stimulate the production of IL-1-beta mRNA.	Calcitriol	76-88	interleukin 1 beta	Homo sapiens	215-224
1498252-6	1992	The cytokines IL-1 alpha (200 pg/ml), tumour necrosis factor alpha (TNF-alpha) (17 ng/ml) and bacterial lipopolysaccharide (LPS) (500 ng/ml) stimulated the production of IL-1 beta mRNA after 6-8 hours.	bacterial lipopolysaccharide	94-122	interleukin 1 beta	Homo sapiens	170-179
1498252-9	1992	Treatment of the cells with hydrocortisone (10(-8) M) resulted in the suppression of both TGF-beta and IL-1 beta mRNA.	Hydrocortisone	28-42	interleukin 1 beta	Homo sapiens	103-112
1315688-2	1992	After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation.	Dinoprostone	217-233	interleukin 1 beta	Homo sapiens	62-71
1315688-2	1992	After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation.	Dinoprostone	217-233	interleukin 1 beta	Homo sapiens	48-52
1315688-2	1992	After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation.	Dinoprostone	235-239	interleukin 1 beta	Homo sapiens	62-71
1315688-2	1992	After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation.	Dinoprostone	235-239	interleukin 1 beta	Homo sapiens	48-52
1315688-2	1992	After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation.	Cyclic AMP	255-259	interleukin 1 beta	Homo sapiens	62-71
1315688-2	1992	After 2 h of stimulation with human recombinant IL-1 alpha or IL-1 beta, the levels of T cell/fibroblast-type IL-1R mRNA increased, and the elevation was sustained for at least 72 h. IL-1 also stimulated synthesis of prostaglandin E2 (PGE2) and secondary cAMP accumulation.	Cyclic AMP	255-259	interleukin 1 beta	Homo sapiens	48-52
1315688-5	1992	Indomethacin blocked IL-1 stimulation of IL-1R mRNA expression, PGE2 production and cAMP.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	21-25
1315688-5	1992	Indomethacin blocked IL-1 stimulation of IL-1R mRNA expression, PGE2 production and cAMP.	Dinoprostone	64-68	interleukin 1 beta	Homo sapiens	21-25
1315688-5	1992	Indomethacin blocked IL-1 stimulation of IL-1R mRNA expression, PGE2 production and cAMP.	Cyclic AMP	84-88	interleukin 1 beta	Homo sapiens	21-25
1315688-9	1992	These results indicate that IL-1 does not directly stimulate expression of IL-1R mRNA or cell surface IL-1R, but only indirectly by stimulation of endogenous PGE2.	Dinoprostone	158-162	interleukin 1 beta	Homo sapiens	28-32
1548355-5	1992	Treatment of decidual cells with actinomycin D or cycloheximide abrogated the increase in IL-6 production induced by IL-1 beta.	Dactinomycin	33-46	interleukin 1 beta	Homo sapiens	117-126
1575744-2	1992	RSF incubated in the presence of IL-1 beta (120 pg/ml) for 18 h secreted 35 fold more PGE2 than did those incubated without IL-1 beta.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	0-3	interleukin 1 beta	Homo sapiens	33-42
1575744-2	1992	RSF incubated in the presence of IL-1 beta (120 pg/ml) for 18 h secreted 35 fold more PGE2 than did those incubated without IL-1 beta.	Dinoprostone	86-90	interleukin 1 beta	Homo sapiens	33-42
1575744-5	1992	The IL-1 beta stimulated, cell-associated PLA2 required submicromolar concentrations of calcium for activity, a characteristic consistent with the calcium sensitivity of cytosolic PLA2 (cPLA2) activity reported in other cell types, such as U937 cells.	Calcium	88-95	interleukin 1 beta	Homo sapiens	4-13
1575744-5	1992	The IL-1 beta stimulated, cell-associated PLA2 required submicromolar concentrations of calcium for activity, a characteristic consistent with the calcium sensitivity of cytosolic PLA2 (cPLA2) activity reported in other cell types, such as U937 cells.	Calcium	147-154	interleukin 1 beta	Homo sapiens	4-13
1575744-6	1992	These findings demonstrate that an elevation in a cytosolic PLA2, rather than a sPLA2, is associated with increased PGE2 production in IL-1 beta stimulated RSF.	Dinoprostone	116-120	interleukin 1 beta	Homo sapiens	135-144
1575744-6	1992	These findings demonstrate that an elevation in a cytosolic PLA2, rather than a sPLA2, is associated with increased PGE2 production in IL-1 beta stimulated RSF.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	156-159	interleukin 1 beta	Homo sapiens	135-144
1373569-5	1992	A 24-h treatment with BLM (0.5-100 mU/ml) was found to result in 1) a concentration-dependent decrease in the ability of the macrophage to produce superoxide anion in response to phorbol 12,13-dibutyrate, 2) an increase in secreted interleukin-1 beta (IL-1 beta), and 3) a decrease in intracellular levels of adenosine 3",5"-cyclic monophosphate.	Bleomycin	22-25	interleukin 1 beta	Homo sapiens	232-250
1373569-5	1992	A 24-h treatment with BLM (0.5-100 mU/ml) was found to result in 1) a concentration-dependent decrease in the ability of the macrophage to produce superoxide anion in response to phorbol 12,13-dibutyrate, 2) an increase in secreted interleukin-1 beta (IL-1 beta), and 3) a decrease in intracellular levels of adenosine 3",5"-cyclic monophosphate.	Bleomycin	22-25	interleukin 1 beta	Homo sapiens	252-261
1373569-6	1992	Kinetic studies revealed a time-dependent appearance of BLM-induced cytokines; tumor necrosis factor-alpha could be detected as early as 4 h after stimulation, followed by IL-1 beta at 8 h. The secretion of these cytokines was found to precede the release of prostaglandin E2, which became significant only at 24 h. Taken together, the present results imply that the human alveolar macrophage does not contribute to BLM-induced oxidant injury of the lung but that it may contribute to the development of BLM-induced pulmonary fibrosis.	Bleomycin	56-59	interleukin 1 beta	Homo sapiens	172-181
1348040-2	1992	The present study examined the possibility that the mechanism underlying the protective effects of IL-1 in experimental nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy is related to effects on gastric acid secretion, on prostaglandin synthesis, and/or on neutrophil function.	Prostaglandins	236-249	interleukin 1 beta	Homo sapiens	99-103
1348040-3	1992	IL-1 alpha and IL-1 beta dose-dependently (1-10 micrograms/kg) reduced the severity of gastric damage induced by indomethacin, whereas tumor necrosis factor alpha (1-10 micrograms/kg) had no effect.	Indomethacin	113-125	interleukin 1 beta	Homo sapiens	15-24
1348040-5	1992	Whereas IL-1 alpha and IL-1 beta significantly inhibited pentagastrin-stimulated acid secretion, the dose-response relationship and time course of actions suggested that effects on acid secretion did not fully account for the ability of these agents to reduce indomethacin-induced gastric injury.	Pentagastrin	57-69	interleukin 1 beta	Homo sapiens	23-32
1348040-6	1992	The maximally effective dose of IL-1 beta (10 micrograms/kg) in terms of reduction of indomethacin-induced gastric injury did not significantly affect gastric prostaglandin synthesis.	Indomethacin	86-98	interleukin 1 beta	Homo sapiens	32-41
1348040-10	1992	Both IL-1 beta and dexamethasone could significantly reduce the extent of histologically detectable leukocyte margination within the gastric mucosal microcirculation after indomethacin administration.	Indomethacin	172-184	interleukin 1 beta	Homo sapiens	5-14
1570335-1	1992	Manidipine, a Ca(2+)-channel blocker, at concentrations that lower elevated blood pressure, modulates the transcription rates of cytokine genes in the mesangial cells of humans that had been stimulated with platelet-derived growth factor BB isomer; although the transcription for mRNA of interleukin 1 beta and granulocyte/monocyte colony-stimulating factor was inhibited, the transcription of mRNA for interleukin 6 was enhanced.	manidipine	0-10	interleukin 1 beta	Homo sapiens	288-357
1631796-1	1992	Diacylglycerol had the same effect and also enhanced synergistically the induction caused by endotoxin and interleukin-1 beta.	Diglycerides	0-14	interleukin 1 beta	Homo sapiens	107-125
1551107-0	1992	Role of aldehyde dehydrogenase in the protection of hematopoietic progenitor cells from 4-hydroperoxycyclophosphamide by interleukin 1 beta and tumor necrosis factor.	perfosfamide	88-117	interleukin 1 beta	Homo sapiens	121-139
1551107-1	1992	Preincubation of human bone marrow cells with interleukin 1 beta (IL-1) and tumor necrosis factor alpha (TNF-alpha) for 20 h can protect early progenitor cells from 4-hydroperoxycyclophosphamide (4-HC) toxicity.	perfosfamide	165-194	interleukin 1 beta	Homo sapiens	46-64
1551107-1	1992	Preincubation of human bone marrow cells with interleukin 1 beta (IL-1) and tumor necrosis factor alpha (TNF-alpha) for 20 h can protect early progenitor cells from 4-hydroperoxycyclophosphamide (4-HC) toxicity.	perfosfamide	165-194	interleukin 1 beta	Homo sapiens	66-70
1551107-1	1992	Preincubation of human bone marrow cells with interleukin 1 beta (IL-1) and tumor necrosis factor alpha (TNF-alpha) for 20 h can protect early progenitor cells from 4-hydroperoxycyclophosphamide (4-HC) toxicity.	perfosfamide	196-200	interleukin 1 beta	Homo sapiens	46-64
1551107-1	1992	Preincubation of human bone marrow cells with interleukin 1 beta (IL-1) and tumor necrosis factor alpha (TNF-alpha) for 20 h can protect early progenitor cells from 4-hydroperoxycyclophosphamide (4-HC) toxicity.	perfosfamide	196-200	interleukin 1 beta	Homo sapiens	66-70
1551107-6	1992	Diethylaminobenzaldehyde was added during the last 10 min of the 20-h preincubation with IL-1 and TNF-alpha.	2-(Diethylamino)benzaldehyde	0-24	interleukin 1 beta	Homo sapiens	89-93
1551107-8	1992	Finally, using the same protection assay system, we showed that a 20-h preincubation with IL-1 and TNF-alpha can also protect early progenitor cells from phenylketophosphamide, an analogue of 4-HC which is resistant to inactivation by ALDH.	phenylketophosphamide	154-175	interleukin 1 beta	Homo sapiens	90-94
1551107-11	1992	Preincubation with IL-1 and TNF-alpha also protects early progenitors from phenylketophosphamide.	phenylketophosphamide	75-96	interleukin 1 beta	Homo sapiens	19-23
1545128-5	1992	The functional relevance of tyrosine phosphorylation induced by TSST-1 was demonstrated by the finding that three specific inhibitors of protein tyrosine kinases strongly inhibited the induction of IL-1 beta mRNA by TSST-1.	Tyrosine	28-36	interleukin 1 beta	Homo sapiens	198-207
1548355-5	1992	Treatment of decidual cells with actinomycin D or cycloheximide abrogated the increase in IL-6 production induced by IL-1 beta.	Cycloheximide	50-63	interleukin 1 beta	Homo sapiens	117-126
1581422-0	1992	Removal of interleukin-1 beta and tumor necrosis factor from human plasma by in vitro dialysis with polyacrylonitrile membranes.	polyacrylonitrile	100-117	interleukin 1 beta	Homo sapiens	11-29
1581422-1	1992	We studied the suitability of in vitro dialysis with polyacrylonitrile (PAN) membranes to remove small amounts of interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF) from plasma to be used as diluent for the standards in radioimmunoassays (RIA).	polyacrylonitrile	53-70	interleukin 1 beta	Homo sapiens	114-132
1581422-1	1992	We studied the suitability of in vitro dialysis with polyacrylonitrile (PAN) membranes to remove small amounts of interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF) from plasma to be used as diluent for the standards in radioimmunoassays (RIA).	polyacrylonitrile	53-70	interleukin 1 beta	Homo sapiens	134-143
1581422-2	1992	Incubation of PAN membrane fragments with radiolabeled IL-1 beta or TNF yielded a significant binding of both cytokines to the membrane (percentage of membrane-bound cytokine after incubation in saline or plasma was 14-17% and 23-46%, respectively).	Sodium Chloride	195-201	interleukin 1 beta	Homo sapiens	55-64
1581422-4	1992	When plasma was dialyzed against saline the percentage of membrane-bound IL-1 beta and TNF was 63 and 37%, respectively.	Sodium Chloride	33-39	interleukin 1 beta	Homo sapiens	73-82
1372187-6	1992	The glucocorticoid, dexamethasone (10(-7) mol/L), inhibited IL-1-stimulated CSF production.	Dexamethasone	20-33	interleukin 1 beta	Homo sapiens	60-64
1532325-0	1992	Identification of a reactive lysyl residue (Lys103) of recombinant human interleukin-1 beta.	lysyl residue	29-42	interleukin 1 beta	Homo sapiens	73-91
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	4-(n,n-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid	80-146	interleukin 1 beta	Homo sapiens	18-36
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	4-(n,n-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid	80-146	interleukin 1 beta	Homo sapiens	40-49
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	4-(N,N-dimethylaminoazobenzene)-4'-isothiocyanate	148-156	interleukin 1 beta	Homo sapiens	18-36
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	4-(N,N-dimethylaminoazobenzene)-4'-isothiocyanate	148-156	interleukin 1 beta	Homo sapiens	40-49
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	Water	161-166	interleukin 1 beta	Homo sapiens	18-36
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	Water	161-166	interleukin 1 beta	Homo sapiens	40-49
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	Lysine	202-208	interleukin 1 beta	Homo sapiens	18-36
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	Lysine	202-208	interleukin 1 beta	Homo sapiens	40-49
1532325-6	1992	The results revealed that Lys103, Lys92, Lys93, and Lys94 of h-IL-1 beta reacted selectively with S-DABITC.	4-(N,N-dimethylaminoazobenzene)-4'-isothiocyanate	98-106	interleukin 1 beta	Homo sapiens	63-72
1532325-9	1992	Furthermore, a mutant of h-IL-1 beta (M9, Glu105 substituted by Lys) exhibits markedly impaired receptor binding, and the S-DABITC reactivity of its Lys103 was found to be reduced by 90%.	4-(N,N-dimethylaminoazobenzene)-4'-isothiocyanate	124-130	interleukin 1 beta	Homo sapiens	27-36
1544467-0	1992	Cytotoxic action of IL-1 beta against pancreatic islets is mediated via nitric oxide formation and is inhibited by NG-monomethyl-L-arginine.	Nitric Oxide	72-84	interleukin 1 beta	Homo sapiens	20-29
1544467-0	1992	Cytotoxic action of IL-1 beta against pancreatic islets is mediated via nitric oxide formation and is inhibited by NG-monomethyl-L-arginine.	omega-N-Methylarginine	115-139	interleukin 1 beta	Homo sapiens	20-29
1544467-2	1992	Here we show by electron microscopy of alginate encapsulated islets, that islet cell lysis is induced by culturing islets for 24 or 48 h in the presence of IL-1 beta.	Alginates	39-47	interleukin 1 beta	Homo sapiens	156-165
1544467-6	1992	The results indicate that IL-1 beta toxicity occurs via inducing in non-endocrine islet cells the synthesis and release of nitric oxide, which has been shown earlier to be highly toxic for islet cells.	Nitric Oxide	123-135	interleukin 1 beta	Homo sapiens	26-35
1531768-5	1992	Receptor-binding activity was studied for mutants (Asp-93)-, (Leu-93)- and des-(Arg-98)interleukin 1 beta"s.	Arginine	80-83	interleukin 1 beta	Homo sapiens	87-105
1531768-9	1992	209, 779-791; Clore, G. M., Wingfield, P. T., &amp; Gronenborn, A. M. (1991) Biochemistry 30, 2315-2323], which forms the receptor-binding site of IL-1 beta.	Adenosine Monophosphate	47-50	interleukin 1 beta	Homo sapiens	147-156
1529798-6	1992	The synovial and skin lines both exhibited a significant stimulation of PGE2 and all three metalloproteinases in response to interleukin-1 beta (IL-1 beta).	Dinoprostone	72-76	interleukin 1 beta	Homo sapiens	125-143
1533388-5	1992	This down-regulation of IL-1RtI by IL-1 is blocked by cycloheximide, suggesting de novo protein synthesis is necessary for decreased RNA stability.	Cycloheximide	54-67	interleukin 1 beta	Homo sapiens	24-28
1373684-4	1992	Addition of IL-1 to cultures stimulated with TNF in the presence of dexamethasone could overcome the inhibitory effects of corticosteroids.	Dexamethasone	68-81	interleukin 1 beta	Homo sapiens	12-16
1545152-5	1992	PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	100-109
1564418-3	1992	As shown in this paper, fusidin also prevents the inhibitory effect of human recombinant IL-1 beta (rIL-1 beta) and the stimulatory effect of human rIL-6, on glucose-induced insulin production in vitro by normal rat pancreatic islets.	Fusidic Acid	24-31	interleukin 1 beta	Homo sapiens	89-98
1529798-6	1992	The synovial and skin lines both exhibited a significant stimulation of PGE2 and all three metalloproteinases in response to interleukin-1 beta (IL-1 beta).	Dinoprostone	72-76	interleukin 1 beta	Homo sapiens	145-154
1371135-2	1992	After treatment with phorbol ester (PMA) or TNF-alpha, a 20- to 40-fold increase in the level of IL-1 beta mRNA was observed in the HIV-infected PLB-IIIB as compared with the parental PLB-985 cells.	Phorbol Esters	21-34	interleukin 1 beta	Homo sapiens	97-106
1531337-0	1992	Site-specific chemical modification of interleukin-1 beta by acrylodan at cysteine 8 and lysine 103.	acrylodan	61-70	interleukin 1 beta	Homo sapiens	39-57
1531337-0	1992	Site-specific chemical modification of interleukin-1 beta by acrylodan at cysteine 8 and lysine 103.	Cysteine	74-82	interleukin 1 beta	Homo sapiens	39-57
1531337-0	1992	Site-specific chemical modification of interleukin-1 beta by acrylodan at cysteine 8 and lysine 103.	Lysine	89-95	interleukin 1 beta	Homo sapiens	39-57
1531337-1	1992	Acrylodan, which normally modifies cysteine residues, was employed to derivatize recombinant interleukin-1 beta (rIL-1 beta) under native conditions, using a reagent:protein ratio of 3:1.	acrylodan	0-9	interleukin 1 beta	Homo sapiens	93-111
1531338-1	1992	We have determined the fluorescence properties of two covalently attached acrylodan derivatives of recombinant human interleukin-1 beta, namely the Cys-8 and Lys-103 adducts.	acrylodan	74-83	interleukin 1 beta	Homo sapiens	117-135
1531338-1	1992	We have determined the fluorescence properties of two covalently attached acrylodan derivatives of recombinant human interleukin-1 beta, namely the Cys-8 and Lys-103 adducts.	Cysteine	148-151	interleukin 1 beta	Homo sapiens	117-135
1531338-1	1992	We have determined the fluorescence properties of two covalently attached acrylodan derivatives of recombinant human interleukin-1 beta, namely the Cys-8 and Lys-103 adducts.	Lysine	158-161	interleukin 1 beta	Homo sapiens	117-135
1371135-2	1992	After treatment with phorbol ester (PMA) or TNF-alpha, a 20- to 40-fold increase in the level of IL-1 beta mRNA was observed in the HIV-infected PLB-IIIB as compared with the parental PLB-985 cells.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	97-106
1539653-0	1992	Effect of intravenous injection of IL-1 beta on PGE2 levels in several brain areas as determined by microdialysis.	Dinoprostone	48-52	interleukin 1 beta	Homo sapiens	35-44
1409001-5	1992	The inhibitory effect of hIL-1 beta was blocked by indomethacin and was not modified by IV injections of the CRF receptor antagonist, alpha-helical CRF(9-41), or the monoclonal somatostatin antibody CURE.S6, or by systemic capsaicin pretreatment.	Indomethacin	51-63	interleukin 1 beta	Homo sapiens	25-35
1409001-5	1992	The inhibitory effect of hIL-1 beta was blocked by indomethacin and was not modified by IV injections of the CRF receptor antagonist, alpha-helical CRF(9-41), or the monoclonal somatostatin antibody CURE.S6, or by systemic capsaicin pretreatment.	Capsaicin	223-232	interleukin 1 beta	Homo sapiens	25-35
1409001-6	1992	These results show that systemic hIL-1 beta-induced inhibition of gastric acid secretion is mediated through IL-1 receptors and prostaglandin pathways, and does not involves CRF receptors, afferent fibers, or changes in circulating gastrin or somatostatin levels.	Prostaglandins	128-141	interleukin 1 beta	Homo sapiens	33-43
1540091-4	1992	Treatment with recombinant human interleukin 1 beta in combination with indomethacin significantly reduced this overproduction of cytokines to normal levels, and this was associated with an improvement in survival after septic challenge (52% survival in interleukin 1 beta-indomethacin-treated group compared with 22% in burned vehicle control mice).	Indomethacin	72-84	interleukin 1 beta	Homo sapiens	254-272
1540091-4	1992	Treatment with recombinant human interleukin 1 beta in combination with indomethacin significantly reduced this overproduction of cytokines to normal levels, and this was associated with an improvement in survival after septic challenge (52% survival in interleukin 1 beta-indomethacin-treated group compared with 22% in burned vehicle control mice).	Indomethacin	273-285	interleukin 1 beta	Homo sapiens	33-51
1309839-8	1992	Bradykinin also stimulated prostaglandin F2 alpha production in both primary decidua cell cultures and fibroblasts in the presence of interleukin-1 beta.	Dinoprost	27-49	interleukin 1 beta	Homo sapiens	134-152
1539653-1	1992	Using perfusion microdialysis, the effect of intravenous injection of recombinant human interleukin-1 beta (IL-1 beta) on prostaglandin E2 (PGE2) release into the interstitial fluid of the organum vasculosum laminae terminalis (OVLT), medial preoptic area (MPOA), paraventricular nucleus (PVN), dorsal hippocampus (HPC), and cerebrospinal fluid (CSF) of the lateral ventricle (LV) was examined.	Dinoprostone	122-138	interleukin 1 beta	Homo sapiens	88-106
1539653-1	1992	Using perfusion microdialysis, the effect of intravenous injection of recombinant human interleukin-1 beta (IL-1 beta) on prostaglandin E2 (PGE2) release into the interstitial fluid of the organum vasculosum laminae terminalis (OVLT), medial preoptic area (MPOA), paraventricular nucleus (PVN), dorsal hippocampus (HPC), and cerebrospinal fluid (CSF) of the lateral ventricle (LV) was examined.	Dinoprostone	122-138	interleukin 1 beta	Homo sapiens	108-117
1539653-1	1992	Using perfusion microdialysis, the effect of intravenous injection of recombinant human interleukin-1 beta (IL-1 beta) on prostaglandin E2 (PGE2) release into the interstitial fluid of the organum vasculosum laminae terminalis (OVLT), medial preoptic area (MPOA), paraventricular nucleus (PVN), dorsal hippocampus (HPC), and cerebrospinal fluid (CSF) of the lateral ventricle (LV) was examined.	Dinoprostone	140-144	interleukin 1 beta	Homo sapiens	88-106
1732280-6	1992	Kinetic analysis demonstrated optimum TNF-alpha mRNA expression after a 4 h exposure to IL-1 beta, and peak TNF-alpha protein production at 18 h. Cycloheximide (CHX), an inhibitor of protein synthesis, markedly increased expression of TNF-alpha mRNA in IL-1 beta stimulated CH235-MG cells, indicating that de novo protein synthesis is not required for astroglioma TNF-alpha gene expression.	Cycloheximide	146-159	interleukin 1 beta	Homo sapiens	88-97
1732280-6	1992	Kinetic analysis demonstrated optimum TNF-alpha mRNA expression after a 4 h exposure to IL-1 beta, and peak TNF-alpha protein production at 18 h. Cycloheximide (CHX), an inhibitor of protein synthesis, markedly increased expression of TNF-alpha mRNA in IL-1 beta stimulated CH235-MG cells, indicating that de novo protein synthesis is not required for astroglioma TNF-alpha gene expression.	Cycloheximide	146-159	interleukin 1 beta	Homo sapiens	253-262
1732280-6	1992	Kinetic analysis demonstrated optimum TNF-alpha mRNA expression after a 4 h exposure to IL-1 beta, and peak TNF-alpha protein production at 18 h. Cycloheximide (CHX), an inhibitor of protein synthesis, markedly increased expression of TNF-alpha mRNA in IL-1 beta stimulated CH235-MG cells, indicating that de novo protein synthesis is not required for astroglioma TNF-alpha gene expression.	Cycloheximide	161-164	interleukin 1 beta	Homo sapiens	253-262
1732280-8	1992	Studies of TNF-alpha mRNA stability using actinomycin D show that IL-1 beta-induced TNF-alpha mRNA has a half-life of approximately 30 min, and CHX increases the half-life of IL-1 beta-induced TNF-alpha mRNA to approximately 210 min.	Dactinomycin	42-55	interleukin 1 beta	Homo sapiens	66-75
1539653-1	1992	Using perfusion microdialysis, the effect of intravenous injection of recombinant human interleukin-1 beta (IL-1 beta) on prostaglandin E2 (PGE2) release into the interstitial fluid of the organum vasculosum laminae terminalis (OVLT), medial preoptic area (MPOA), paraventricular nucleus (PVN), dorsal hippocampus (HPC), and cerebrospinal fluid (CSF) of the lateral ventricle (LV) was examined.	Dinoprostone	140-144	interleukin 1 beta	Homo sapiens	108-117
1539653-3	1992	The results showed that 1) IL-1 beta induced a significant increase in PGE2 levels in the OVLT and the medial part of the MPOA in the first 20 min, which is more rapid and to a greater extent than that in PVN, HPC, and LV; 2) inclusion of indomethacin in the perfusate abolished the IL-1 beta-induced PGE2 response in the OVLT, but a suppressive effect in the PVN was insignificant.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	27-36
1539653-3	1992	The results showed that 1) IL-1 beta induced a significant increase in PGE2 levels in the OVLT and the medial part of the MPOA in the first 20 min, which is more rapid and to a greater extent than that in PVN, HPC, and LV; 2) inclusion of indomethacin in the perfusate abolished the IL-1 beta-induced PGE2 response in the OVLT, but a suppressive effect in the PVN was insignificant.	Dinoprostone	71-75	interleukin 1 beta	Homo sapiens	283-292
1539653-3	1992	The results showed that 1) IL-1 beta induced a significant increase in PGE2 levels in the OVLT and the medial part of the MPOA in the first 20 min, which is more rapid and to a greater extent than that in PVN, HPC, and LV; 2) inclusion of indomethacin in the perfusate abolished the IL-1 beta-induced PGE2 response in the OVLT, but a suppressive effect in the PVN was insignificant.	Indomethacin	239-251	interleukin 1 beta	Homo sapiens	27-36
1539653-3	1992	The results showed that 1) IL-1 beta induced a significant increase in PGE2 levels in the OVLT and the medial part of the MPOA in the first 20 min, which is more rapid and to a greater extent than that in PVN, HPC, and LV; 2) inclusion of indomethacin in the perfusate abolished the IL-1 beta-induced PGE2 response in the OVLT, but a suppressive effect in the PVN was insignificant.	Dinoprostone	301-305	interleukin 1 beta	Homo sapiens	27-36
1561233-0	1992	Interaction of paracrine factors during labour: interleukin-1 beta causes amplification of decidua cell prostaglandin F2 alpha production in response to bradykinin and epidermal growth factor.	Dinoprost	104-126	interleukin 1 beta	Homo sapiens	48-66
19912845-4	1992	During short-term incubations of U87MG cells (6 h) in the presence of IL 1beta and dexamethasone (DEX), DEX inhibited IL 1beta-stimulated IL 6 production over the entire range of the dose-response curve.	Dexamethasone	83-96	interleukin 1 beta	Homo sapiens	118-126
19912845-4	1992	During short-term incubations of U87MG cells (6 h) in the presence of IL 1beta and dexamethasone (DEX), DEX inhibited IL 1beta-stimulated IL 6 production over the entire range of the dose-response curve.	Dexamethasone	98-101	interleukin 1 beta	Homo sapiens	118-126
19912845-4	1992	During short-term incubations of U87MG cells (6 h) in the presence of IL 1beta and dexamethasone (DEX), DEX inhibited IL 1beta-stimulated IL 6 production over the entire range of the dose-response curve.	Dexamethasone	104-107	interleukin 1 beta	Homo sapiens	70-78
19912845-4	1992	During short-term incubations of U87MG cells (6 h) in the presence of IL 1beta and dexamethasone (DEX), DEX inhibited IL 1beta-stimulated IL 6 production over the entire range of the dose-response curve.	Dexamethasone	104-107	interleukin 1 beta	Homo sapiens	118-126
19912845-5	1992	However, when cells were preincubated in the presence of DEX for 15 h and then challenged with IL 1beta or IL 1beta and DEX, there was a left-shift in the IL 1,B dose-response curve, suggesting an increased sensitivity of the cells to respond to IL 1 and produce IL 6.	Dexamethasone	57-60	interleukin 1 beta	Homo sapiens	95-103
19912845-5	1992	However, when cells were preincubated in the presence of DEX for 15 h and then challenged with IL 1beta or IL 1beta and DEX, there was a left-shift in the IL 1,B dose-response curve, suggesting an increased sensitivity of the cells to respond to IL 1 and produce IL 6.	Dexamethasone	57-60	interleukin 1 beta	Homo sapiens	107-115
19912845-5	1992	However, when cells were preincubated in the presence of DEX for 15 h and then challenged with IL 1beta or IL 1beta and DEX, there was a left-shift in the IL 1,B dose-response curve, suggesting an increased sensitivity of the cells to respond to IL 1 and produce IL 6.	Dexamethasone	57-60	interleukin 1 beta	Homo sapiens	155-161
19912845-5	1992	However, when cells were preincubated in the presence of DEX for 15 h and then challenged with IL 1beta or IL 1beta and DEX, there was a left-shift in the IL 1,B dose-response curve, suggesting an increased sensitivity of the cells to respond to IL 1 and produce IL 6.	Dexamethasone	120-123	interleukin 1 beta	Homo sapiens	155-161
19912845-6	1992	In fact, the ED(50) for IL 1beta-stimulated IL 6 production was about 1.3 pM in cells not preincubated with DEX, but was reduced to 0.25 pM in cells that were preincubated with DEX.	Dexamethasone	108-111	interleukin 1 beta	Homo sapiens	24-32
19912845-6	1992	In fact, the ED(50) for IL 1beta-stimulated IL 6 production was about 1.3 pM in cells not preincubated with DEX, but was reduced to 0.25 pM in cells that were preincubated with DEX.	Dexamethasone	177-180	interleukin 1 beta	Homo sapiens	24-32
1561233-2	1992	The aim of the present study is to investigate a potential interaction between interleukin-1 beta (IL-1) and bradykinin (BK) in the regulation of decidual PGF2 alpha production and PG precursor release.	Dinoprost	155-159	interleukin 1 beta	Homo sapiens	79-97
19912845-7	1992	However, maximum IL 6 production at high doses of IL 1beta was inhibited in cells cultured in the presence of DEX during the IL 1 challenge.	Dexamethasone	110-113	interleukin 1 beta	Homo sapiens	50-58
1741416-3	1992	We have employed IgG and IgE-coated Sepharose beads to investigate selective modulation of IgG and IgE-mediated enzyme release by IL-1 beta.	Sepharose	36-45	interleukin 1 beta	Homo sapiens	130-139
1561233-2	1992	The aim of the present study is to investigate a potential interaction between interleukin-1 beta (IL-1) and bradykinin (BK) in the regulation of decidual PGF2 alpha production and PG precursor release.	Dinoprost	155-159	interleukin 1 beta	Homo sapiens	99-103
1310816-1	1992	The capability of elevated intracellular cyclic AMP concentration to activate IL-1 gene expression and protein production was examined in human peripheral blood monocytes.	Cyclic AMP	41-51	interleukin 1 beta	Homo sapiens	78-82
1310816-3	1992	However, if the degradation of cyclic AMP was inhibited with isobutyl-methyl-xanthine (IBMX), IL-1 production was strongly activated.	Cyclic AMP	31-41	interleukin 1 beta	Homo sapiens	94-98
1310816-3	1992	However, if the degradation of cyclic AMP was inhibited with isobutyl-methyl-xanthine (IBMX), IL-1 production was strongly activated.	1-Methyl-3-isobutylxanthine	87-91	interleukin 1 beta	Homo sapiens	94-98
1310816-5	1992	The cyclic AMP-induced IL-1 production differed in some aspects from the bacterial lipopolysaccharide-induced IL-1 production: (1) the kinetics of both IL-1 gene expression and protein production was much slower; (2) the IL-1 beta gene expression was superinducible by inhibiting the protein synthesis with cycloheximide.	Cyclic AMP	4-14	interleukin 1 beta	Homo sapiens	23-27
1561233-2	1992	The aim of the present study is to investigate a potential interaction between interleukin-1 beta (IL-1) and bradykinin (BK) in the regulation of decidual PGF2 alpha production and PG precursor release.	Prostaglandins	155-157	interleukin 1 beta	Homo sapiens	79-97
1310816-5	1992	The cyclic AMP-induced IL-1 production differed in some aspects from the bacterial lipopolysaccharide-induced IL-1 production: (1) the kinetics of both IL-1 gene expression and protein production was much slower; (2) the IL-1 beta gene expression was superinducible by inhibiting the protein synthesis with cycloheximide.	Cyclic AMP	4-14	interleukin 1 beta	Homo sapiens	221-230
1310816-5	1992	The cyclic AMP-induced IL-1 production differed in some aspects from the bacterial lipopolysaccharide-induced IL-1 production: (1) the kinetics of both IL-1 gene expression and protein production was much slower; (2) the IL-1 beta gene expression was superinducible by inhibiting the protein synthesis with cycloheximide.	Cycloheximide	307-320	interleukin 1 beta	Homo sapiens	23-27
1561233-2	1992	The aim of the present study is to investigate a potential interaction between interleukin-1 beta (IL-1) and bradykinin (BK) in the regulation of decidual PGF2 alpha production and PG precursor release.	Prostaglandins	155-157	interleukin 1 beta	Homo sapiens	99-103
1310816-5	1992	The cyclic AMP-induced IL-1 production differed in some aspects from the bacterial lipopolysaccharide-induced IL-1 production: (1) the kinetics of both IL-1 gene expression and protein production was much slower; (2) the IL-1 beta gene expression was superinducible by inhibiting the protein synthesis with cycloheximide.	Cycloheximide	307-320	interleukin 1 beta	Homo sapiens	221-230
1310816-6	1992	Thus these data suggest that prolonged elevation of cyclic AMP is alone a sufficient signal to activate IL-1 production.	Cyclic AMP	52-62	interleukin 1 beta	Homo sapiens	104-108
1561233-3	1992	Pretreatment of primary decidua cell cultures with IL-1 significantly enhanced PGF2 alpha production in response to BK.	Dinoprost	79-83	interleukin 1 beta	Homo sapiens	51-55
1561233-6	1992	Decidual fibroblasts pretreated with IL-1 manifest a 10-fold increase in PGF2 alpha production in response to BK and EGF.	Dinoprost	73-77	interleukin 1 beta	Homo sapiens	37-41
1729366-7	1992	Metabolically labeled IL-1 beta-stimulated chondrocytes synthesize IL-8 de novo, which comigrates on SDS-PAGE with IL-8 produced by synovial fibroblasts.	Sodium Dodecyl Sulfate	101-104	interleukin 1 beta	Homo sapiens	22-31
1309558-0	1992	The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production.	Prostaglandins	75-88	interleukin 1 beta	Homo sapiens	48-52
1309558-7	1992	The toxin, or its B oligomer, inhibited PGE2 synthesis in human gingival fibroblasts stimulated by IL-1, but not by PMA.	Dinoprostone	40-44	interleukin 1 beta	Homo sapiens	99-103
1309561-9	1992	Finally, the decrease in PDGF beta-receptors after culturing of the cells in the presence of TNF-alpha and IL-1 was accompanied by a decreased incorporation of [3H]thymidine in response to PDGF-BB stimulation.	[3h]thymidine	160-173	interleukin 1 beta	Homo sapiens	107-111
1546442-2	1992	Human interleukin-1 beta was about three to ten times as active on equine synovial cells as human interleukin-1 alpha in terms of prostaglandin E2 production.	Dinoprostone	130-146	interleukin 1 beta	Homo sapiens	6-24
1730100-2	1992	Initial experiments designed to validate the assay revealed that the number of IL-1 beta spot forming cells was increased by exposing normal blood monocytes to LPS and that spot formation was prevented by incubating the cells with cycloheximide.	Cycloheximide	231-244	interleukin 1 beta	Homo sapiens	79-88
1319762-3	1992	The binding sites appeared to be predominantly type II since phorbol ester treatment of the cells, which selectively downregulates type II IL-1 receptors, reduced binding by 68% while treatment of the cells with an inhibitory monoclonal antibody specific for the type I receptor had no significant effect on IL-1 binding.	Phorbol Esters	61-74	interleukin 1 beta	Homo sapiens	139-143
1628488-4	1992	Treatment with Interleukin-1 (Il-1) or retinol resulted in diminished synthesis and enhanced catabolism of matrix proteoglycans, but the chondrocytes were more sensitive to human recombinant Il-1 alpha than to Il-1 beta.	Vitamin A	39-46	interleukin 1 beta	Homo sapiens	210-219
1309493-7	1992	Superoxide anion production and candicidal activity were measured in the presence of TNF-alpha and IL-1 beta.	Superoxides	0-16	interleukin 1 beta	Homo sapiens	99-108
1309493-9	1992	Diminished TNF-alpha and IL-1 beta binding reduced superoxide anion production by group 2 polymorphonuclear leukocytes.	Superoxides	51-67	interleukin 1 beta	Homo sapiens	25-34
1319762-3	1992	The binding sites appeared to be predominantly type II since phorbol ester treatment of the cells, which selectively downregulates type II IL-1 receptors, reduced binding by 68% while treatment of the cells with an inhibitory monoclonal antibody specific for the type I receptor had no significant effect on IL-1 binding.	Phorbol Esters	61-74	interleukin 1 beta	Homo sapiens	308-312
1582733-1	1992	The effect of intravenous administration of lentinan, an immunopotentiating polysaccharide, on the production of interleukin 1-alpha (IL 1-alpha), interleukin 1-beta (IL 1-beta) and tumor necrosis factor-alpha (TNF-alpha) by monocytes in peripheral blood mononuclear cells (PBM) was studied in patients with gastric carcinoma.	Lentinan	44-52	interleukin 1 beta	Homo sapiens	147-165
1547025-2	1992	In the present study we have investigated the modulation of LPS by the synthetic non-active tetraacylated precursor Ia of lipid A (compound 406) in the induction of tumor necrosis factor (TNF), interleukin 1 (IL-1) and interleukin 6 (IL-6) in human peripheral blood mononuclear cells (PBMC) and in human peripheral blood monocytes (PBMo).	Lipid A	122-129	interleukin 1 beta	Homo sapiens	194-214
1582733-1	1992	The effect of intravenous administration of lentinan, an immunopotentiating polysaccharide, on the production of interleukin 1-alpha (IL 1-alpha), interleukin 1-beta (IL 1-beta) and tumor necrosis factor-alpha (TNF-alpha) by monocytes in peripheral blood mononuclear cells (PBM) was studied in patients with gastric carcinoma.	Lentinan	44-52	interleukin 1 beta	Homo sapiens	167-176
1371299-3	1992	Paraformaldehyde-fixed macrophages like-wise showed augmentation of IL-1 activity, but whereas all of the bioactivity associated with the fixed macrophages could be neutralized by anti-IL-1 alpha antibody only approximately 40% of the supernate activity could be attributed to IL-1 alpha.	paraform	0-16	interleukin 1 beta	Homo sapiens	68-72
1339917-6	1992	The effect of methyl B12 on IL-1 beta production on Day I of the culture was small.	mecobalamin	14-24	interleukin 1 beta	Homo sapiens	28-37
1508964-1	1992	We determined a protective action of probucol (4,4"-[isopropylidenedithio]bis[2,6-di-tert-butylphenol]) on the reduction of serum immunoreactive insulin (IRI) levels by recombinant human interleukin-1 beta (IL-1) in adrenalectomized rats.	Probucol	37-45	interleukin 1 beta	Homo sapiens	187-205
1508964-1	1992	We determined a protective action of probucol (4,4"-[isopropylidenedithio]bis[2,6-di-tert-butylphenol]) on the reduction of serum immunoreactive insulin (IRI) levels by recombinant human interleukin-1 beta (IL-1) in adrenalectomized rats.	Probucol	37-45	interleukin 1 beta	Homo sapiens	207-211
1508964-1	1992	We determined a protective action of probucol (4,4"-[isopropylidenedithio]bis[2,6-di-tert-butylphenol]) on the reduction of serum immunoreactive insulin (IRI) levels by recombinant human interleukin-1 beta (IL-1) in adrenalectomized rats.	Probucol	47-101	interleukin 1 beta	Homo sapiens	187-205
1508964-1	1992	We determined a protective action of probucol (4,4"-[isopropylidenedithio]bis[2,6-di-tert-butylphenol]) on the reduction of serum immunoreactive insulin (IRI) levels by recombinant human interleukin-1 beta (IL-1) in adrenalectomized rats.	Probucol	47-101	interleukin 1 beta	Homo sapiens	207-211
1508964-4	1992	In contrast, IL-1 decreased plasma glucose levels in both groups.	Glucose	35-42	interleukin 1 beta	Homo sapiens	13-17
1409221-7	1992	The effect of phytohaemagglutinin or concanavalin A on the production of interleukin-1b, interleukin-2 and interleukin-2 receptors is profoundly affected by deoxypyridoxine.	4-deoxypyridoxine	157-172	interleukin 1 beta	Homo sapiens	73-87
1508964-5	1992	Although IL-1 reduced plasma prostaglandin (PG) E2 levels in standard diet-fed rats, IL-1 did not affect plasma PGE2 levels in the animals fed the probucol-containing diet.	Dinoprostone	29-50	interleukin 1 beta	Homo sapiens	9-13
1455368-6	1992	The RA patients demonstrated direct correlations between the level of IL-1 beta, TNF-alpha and PGE2 in supernatants of PBM, whereas the donors showed up a negative correlation between IL-1 beta activity and PGE2.	Dinoprostone	95-99	interleukin 1 beta	Homo sapiens	70-79
1455368-6	1992	The RA patients demonstrated direct correlations between the level of IL-1 beta, TNF-alpha and PGE2 in supernatants of PBM, whereas the donors showed up a negative correlation between IL-1 beta activity and PGE2.	Dinoprostone	207-211	interleukin 1 beta	Homo sapiens	184-193
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Arginine	25-28	interleukin 1 beta	Homo sapiens	106-115
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Leucine	32-35	interleukin 1 beta	Homo sapiens	106-115
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Phenylalanine	39-42	interleukin 1 beta	Homo sapiens	106-115
1660474-3	1991	The collagenase gene is transcriptionally activated in normal dermal or rheumatoid synovial fibroblasts by interleukin-1 beta (IL-1 beta), resulting in secretion of trypsin-activatable procollagenase measuring in the range of 2.0-5.0 units/10(6) cells/48 h in the 14C-fibril assay.	Carbon-14	264-267	interleukin 1 beta	Homo sapiens	107-125
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Isoleucine	47-50	interleukin 1 beta	Homo sapiens	106-115
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Lysine	55-58	interleukin 1 beta	Homo sapiens	106-115
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Lysine	63-66	interleukin 1 beta	Homo sapiens	106-115
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Glutamic Acid	76-79	interleukin 1 beta	Homo sapiens	106-115
1837236-5	1991	The stoichiometry of this modification revealed that a single arginine in either IL-1 alpha or IL-1 beta is responsible for the loss of activity.	Arginine	62-70	interleukin 1 beta	Homo sapiens	95-104
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Cyanogen Bromide	0-16	interleukin 1 beta	Homo sapiens	67-76
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Cyanogen Bromide	0-16	interleukin 1 beta	Homo sapiens	176-185
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Phenylglyoxal	29-42	interleukin 1 beta	Homo sapiens	67-76
1660474-3	1991	The collagenase gene is transcriptionally activated in normal dermal or rheumatoid synovial fibroblasts by interleukin-1 beta (IL-1 beta), resulting in secretion of trypsin-activatable procollagenase measuring in the range of 2.0-5.0 units/10(6) cells/48 h in the 14C-fibril assay.	Carbon-14	264-267	interleukin 1 beta	Homo sapiens	127-136
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Phenylglyoxal	29-42	interleukin 1 beta	Homo sapiens	176-185
1767825-9	1991	IL-1 beta significantly reduced PDGF-AA binding and significantly decreased both PDGF-AA-mediated cell migration and thymidine incorporation.	Thymidine	117-126	interleukin 1 beta	Homo sapiens	0-9
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	132-140	interleukin 1 beta	Homo sapiens	67-76
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	132-140	interleukin 1 beta	Homo sapiens	176-185
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	162-170	interleukin 1 beta	Homo sapiens	67-76
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	162-170	interleukin 1 beta	Homo sapiens	176-185
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Phenylglyoxal	283-296	interleukin 1 beta	Homo sapiens	176-185
1955561-0	1991	Benzodiazepine anesthesia in humans modulates the interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6 responses of blood monocytes.	Benzodiazepines	0-14	interleukin 1 beta	Homo sapiens	50-97
1937822-1	1991	Lipoteichoic acids (LTAs) isolated from bacterial species, including Staphylococcus aureus, Streptococcus pyogenes A, Enterococcus faecalis, Streptococcus pneumoniae, and Listeria monocytogenes, were tested for their ability to stimulate the production of interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha in cultured human monocytes.	lipoteichoic acid	0-18	interleukin 1 beta	Homo sapiens	276-285
1661707-2	1991	IL-1 alpha and IL-1 beta stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts with IL-1 beta being the most potent agonist.	Dinoprostone	36-52	interleukin 1 beta	Homo sapiens	15-24
1661707-2	1991	IL-1 alpha and IL-1 beta stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts with IL-1 beta being the most potent agonist.	Dinoprostone	54-58	interleukin 1 beta	Homo sapiens	15-24
1661707-3	1991	The effects of both IL-1 alpha and IL-1 beta on PGE2 biosynthesis was synergistically potentiated by BK, in a dose-related manner.	Dinoprostone	48-52	interleukin 1 beta	Homo sapiens	35-44
1661707-4	1991	The synergistic interaction between IL-1 beta and BK on PGE2 production was seen both with B1 (des-Arg9-BK) and B2 (BK, Lys-BK) BK receptor agonists.	Dinoprostone	56-60	interleukin 1 beta	Homo sapiens	36-45
1661292-1	1991	The effects of increasing intracellular cAMP levels on IL-1 alpha and IL-1 beta mRNA expression and IL-1 production in human monocytes and nonlymphoid hematopoietic cell lines were examined.	Cyclic AMP	40-44	interleukin 1 beta	Homo sapiens	70-79
1661292-1	1991	The effects of increasing intracellular cAMP levels on IL-1 alpha and IL-1 beta mRNA expression and IL-1 production in human monocytes and nonlymphoid hematopoietic cell lines were examined.	Cyclic AMP	40-44	interleukin 1 beta	Homo sapiens	55-59
1661292-2	1991	Peripheral monocytes and myelomonocytic cell lines could be stimulated by LPS or phorbol myristate acetate (PMA) to express IL-1 mRNA.	Tetradecanoylphorbol Acetate	81-106	interleukin 1 beta	Homo sapiens	124-128
1661292-2	1991	Peripheral monocytes and myelomonocytic cell lines could be stimulated by LPS or phorbol myristate acetate (PMA) to express IL-1 mRNA.	Tetradecanoylphorbol Acetate	108-111	interleukin 1 beta	Homo sapiens	124-128
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	dibutyryl	0-9	interleukin 1 beta	Homo sapiens	189-198
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Dinoprostone	66-70	interleukin 1 beta	Homo sapiens	189-198
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Tetradecanoylphorbol Acetate	87-90	interleukin 1 beta	Homo sapiens	189-198
1955561-3	1991	injection of 0.08 mg/kg midazolam induced a marked and delayed inhibition of the lipopolysaccharide-induced production of interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6 by monocytes isolated from peripheral blood.	Midazolam	24-33	interleukin 1 beta	Homo sapiens	122-169
1804308-2	1991	For this reason we attempted to localize IL-1 alpha and IL-1 beta directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy using immunohistochemical techniques and specific antibodies.	Formaldehyde	78-86	interleukin 1 beta	Homo sapiens	56-65
1666517-0	1991	Cholera toxin synergizes LPS- and IL-1 beta-induced PGE2 release: potential amplification systems in cholera.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	34-43
1666517-1	1991	Incubation of LPS/IL-1 beta and cholera toxin combinations resulted in a synergistic rise of immunoreactive and [3H]PGE2 released from HGFs.	Tritium	113-115	interleukin 1 beta	Homo sapiens	18-27
1666517-1	1991	Incubation of LPS/IL-1 beta and cholera toxin combinations resulted in a synergistic rise of immunoreactive and [3H]PGE2 released from HGFs.	Dinoprostone	116-120	interleukin 1 beta	Homo sapiens	18-27
1804308-2	1991	For this reason we attempted to localize IL-1 alpha and IL-1 beta directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy using immunohistochemical techniques and specific antibodies.	Paraffin	93-101	interleukin 1 beta	Homo sapiens	56-65
1788056-2	1991	Fever induced by icv administration of recombinant human interleukin-1 beta (rhIL-1 beta) was depressed by either icv or sc pretreatment with indomethacin.	icv	17-20	interleukin 1 beta	Homo sapiens	57-75
1787257-2	1991	administration of recombinant human interleukin-1 beta (rhIL-1 beta) on the activity of adrenal, splenic and renal sympathetic nerves were observed in urethane-anesthetized rats.	Urethane	151-159	interleukin 1 beta	Homo sapiens	36-54
1788056-2	1991	Fever induced by icv administration of recombinant human interleukin-1 beta (rhIL-1 beta) was depressed by either icv or sc pretreatment with indomethacin.	icv	114-117	interleukin 1 beta	Homo sapiens	57-75
1788056-2	1991	Fever induced by icv administration of recombinant human interleukin-1 beta (rhIL-1 beta) was depressed by either icv or sc pretreatment with indomethacin.	Indomethacin	142-154	interleukin 1 beta	Homo sapiens	57-75
1815239-7	1991	The combinations of IL-1 alpha or IL-1 beta with either TNF-alpha or TNF-beta caused a synergistic stimulation of amnion cell PGE2 production as well, whereas the combinations of IL-1 alpha with IL-1 beta or of TNF-alpha with TNF-beta were not synergistic.	Dinoprostone	126-130	interleukin 1 beta	Homo sapiens	34-43
1835838-3	1991	The human IL1 beta molecule contains a seven-amino-acid sequence (-Pro208-Lys-Lys-Lys-Met-Glu-Lys-) that shows some sequence identity with the nuclear localization sequence of the simian-virus-40 large T-antigen.	Lysine	74-77	interleukin 1 beta	Homo sapiens	10-18
1748298-12	1991	A modified form of IL-1 beta (Asn7----Gln7), in which the unique site for Asn-linked glycosylation was deleted, exhibited the same biological activity as native IL-1 beta.	asn7----gln7	30-42	interleukin 1 beta	Homo sapiens	19-28
1748298-12	1991	A modified form of IL-1 beta (Asn7----Gln7), in which the unique site for Asn-linked glycosylation was deleted, exhibited the same biological activity as native IL-1 beta.	asn7----gln7	30-42	interleukin 1 beta	Homo sapiens	161-170
1657959-0	1991	Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans.	Iron	55-59	interleukin 1 beta	Homo sapiens	0-18
1657959-1	1991	Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.	Nitric Oxide	8-20	interleukin 1 beta	Homo sapiens	24-42
1657959-3	1991	Evidence is presented which suggests that IL-1 beta-induced inhibition of insulin secretion is dependent on the metabolism of L-arginine to nitric oxide.	Arginine	126-136	interleukin 1 beta	Homo sapiens	42-51
1657959-3	1991	Evidence is presented which suggests that IL-1 beta-induced inhibition of insulin secretion is dependent on the metabolism of L-arginine to nitric oxide.	Nitric Oxide	140-152	interleukin 1 beta	Homo sapiens	42-51
1657959-5	1991	It is further shown that IL-1 beta induces nitric oxide formation in islets as evidenced by an electron paramagnetic resonance feature at g = 2.04 which is similar to previously reported iron-nitrosyl complexes formed from the destruction of iron-sulfur centers by nitric oxide.	Nitric Oxide	43-55	interleukin 1 beta	Homo sapiens	25-34
1657959-5	1991	It is further shown that IL-1 beta induces nitric oxide formation in islets as evidenced by an electron paramagnetic resonance feature at g = 2.04 which is similar to previously reported iron-nitrosyl complexes formed from the destruction of iron-sulfur centers by nitric oxide.	Iron	187-191	interleukin 1 beta	Homo sapiens	25-34
1657959-5	1991	It is further shown that IL-1 beta induces nitric oxide formation in islets as evidenced by an electron paramagnetic resonance feature at g = 2.04 which is similar to previously reported iron-nitrosyl complexes formed from the destruction of iron-sulfur centers by nitric oxide.	Iron	242-246	interleukin 1 beta	Homo sapiens	25-34
1657959-5	1991	It is further shown that IL-1 beta induces nitric oxide formation in islets as evidenced by an electron paramagnetic resonance feature at g = 2.04 which is similar to previously reported iron-nitrosyl complexes formed from the destruction of iron-sulfur centers by nitric oxide.	Sulfur	247-253	interleukin 1 beta	Homo sapiens	25-34
1657959-5	1991	It is further shown that IL-1 beta induces nitric oxide formation in islets as evidenced by an electron paramagnetic resonance feature at g = 2.04 which is similar to previously reported iron-nitrosyl complexes formed from the destruction of iron-sulfur centers by nitric oxide.	Nitric Oxide	265-277	interleukin 1 beta	Homo sapiens	25-34
1748298-12	1991	A modified form of IL-1 beta (Asn7----Gln7), in which the unique site for Asn-linked glycosylation was deleted, exhibited the same biological activity as native IL-1 beta.	Asparagine	30-33	interleukin 1 beta	Homo sapiens	19-28
1748298-12	1991	A modified form of IL-1 beta (Asn7----Gln7), in which the unique site for Asn-linked glycosylation was deleted, exhibited the same biological activity as native IL-1 beta.	Asparagine	30-33	interleukin 1 beta	Homo sapiens	161-170
1835838-3	1991	The human IL1 beta molecule contains a seven-amino-acid sequence (-Pro208-Lys-Lys-Lys-Met-Glu-Lys-) that shows some sequence identity with the nuclear localization sequence of the simian-virus-40 large T-antigen.	Lysine	78-81	interleukin 1 beta	Homo sapiens	10-18
1835838-3	1991	The human IL1 beta molecule contains a seven-amino-acid sequence (-Pro208-Lys-Lys-Lys-Met-Glu-Lys-) that shows some sequence identity with the nuclear localization sequence of the simian-virus-40 large T-antigen.	Glutamic Acid	90-93	interleukin 1 beta	Homo sapiens	10-18
1835838-3	1991	The human IL1 beta molecule contains a seven-amino-acid sequence (-Pro208-Lys-Lys-Lys-Met-Glu-Lys-) that shows some sequence identity with the nuclear localization sequence of the simian-virus-40 large T-antigen.	Lysine	78-81	interleukin 1 beta	Homo sapiens	10-18
1953785-3	1991	When human monocytes were preincubated with dexamethasone for 1 hour and then stimulated either with bacterial lipopolysaccharide or phorbol myristate, it was found that dexamethasone inhibited the lipopolysaccharide-induced interleukin-1 beta protein production, but the phorbol myristate-induced production was increased 3-10 fold.	Dexamethasone	170-183	interleukin 1 beta	Homo sapiens	225-243
1953785-5	1991	When dexamethasone was added to the cultures 3 hours after the stimulators, it clearly decreased the interleukin-1 beta mRNA levels regardless of the stimulator used (although the effect was clearly weaker on the PMA-induced mRNA).	Dexamethasone	5-18	interleukin 1 beta	Homo sapiens	101-119
1663075-3	1991	Polyinosinic acid (poly I) and fucoidan, both ligands known to bind to the scavenger receptor, induced IL-1 beta production in human monocytes.	Poly I	0-17	interleukin 1 beta	Homo sapiens	103-112
1790549-2	1991	When PBMCs were cultured with propentofylline in vitro, the production of IL-6 was markedly increased at concentrations of 0.1 to 3.0 mmol/L of propentofylline and the production of IL-1 beta was slightly increased at concentrations of 1.0 to 3.0 mmol/L.	propentofylline	30-45	interleukin 1 beta	Homo sapiens	182-191
1790549-5	1991	The results demonstrate that propentofylline has a differential effect on the production of IL-6, IL-1 beta, and TNF-alpha by PBMCs, and it is proposed that propentofylline may exert pharmacologic actions on the regulation of the production of cytokines in the central nervous system.	propentofylline	29-44	interleukin 1 beta	Homo sapiens	98-107
1717193-4	1991	The mechanism by which ATRA enhances IL-1-induced HSN proliferation does not appear mediated by changes in the affinity or number of IL-1 receptors expressed by HSN; however, treatment with dexamethasone (DEX, 10(-6)M) resulted in a twofold increase in IL-1 receptor number.	Tretinoin	23-27	interleukin 1 beta	Homo sapiens	37-41
1717193-4	1991	The mechanism by which ATRA enhances IL-1-induced HSN proliferation does not appear mediated by changes in the affinity or number of IL-1 receptors expressed by HSN; however, treatment with dexamethasone (DEX, 10(-6)M) resulted in a twofold increase in IL-1 receptor number.	Dexamethasone	190-203	interleukin 1 beta	Homo sapiens	37-41
1717193-5	1991	ATRA inhibited both IL-1 beta- and TNF alpha-induced secretion of prostaglandin-E2 (PGE2), a potent feedback inhibitor of cytokine-stimulated HSN proliferation.	Tretinoin	0-4	interleukin 1 beta	Homo sapiens	20-29
1717193-5	1991	ATRA inhibited both IL-1 beta- and TNF alpha-induced secretion of prostaglandin-E2 (PGE2), a potent feedback inhibitor of cytokine-stimulated HSN proliferation.	Dinoprostone	66-82	interleukin 1 beta	Homo sapiens	20-29
1717193-5	1991	ATRA inhibited both IL-1 beta- and TNF alpha-induced secretion of prostaglandin-E2 (PGE2), a potent feedback inhibitor of cytokine-stimulated HSN proliferation.	Dinoprostone	84-88	interleukin 1 beta	Homo sapiens	20-29
1717193-6	1991	However, the synergistic effect of ATRA on IL-1- or FGF-induced proliferation did not appear related to the secretion of cyclooxygenase products since ATRA had no effect on TNF alpha-induced HSN proliferation and indomethacin was included in all HSN proliferation experiments.	Tretinoin	35-39	interleukin 1 beta	Homo sapiens	43-47
1663075-3	1991	Polyinosinic acid (poly I) and fucoidan, both ligands known to bind to the scavenger receptor, induced IL-1 beta production in human monocytes.	Poly I	19-25	interleukin 1 beta	Homo sapiens	103-112
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	96-117	interleukin 1 beta	Homo sapiens	46-55
1663075-3	1991	Polyinosinic acid (poly I) and fucoidan, both ligands known to bind to the scavenger receptor, induced IL-1 beta production in human monocytes.	fucoidan	31-39	interleukin 1 beta	Homo sapiens	103-112
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	119-122	interleukin 1 beta	Homo sapiens	46-55
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	127-130	interleukin 1 beta	Homo sapiens	46-55
1660901-6	1991	By contrast, although increasing amounts of biologically active IL1 beta were detected in the supernatants of TDI-exposed epithelial cells throughout the 6-day period following exposure, augmented levels of IL1 beta mRNA were only evident 6 days after exposure, suggesting that TDI exposure might have initially affected the enzymatic cleavage of the intracellular IL1 beta precursor and the mechanisms which regulate the secretion of mature IL1 beta.	Toluene 2,4-Diisocyanate	110-113	interleukin 1 beta	Homo sapiens	64-72
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	Ionomycin	136-145	interleukin 1 beta	Homo sapiens	46-55
1834761-3	1991	Binding was found to be displaceable by mature human and murine IL-1 beta and human 31-kD IL-1 beta propeptide, but not displaceable by human and murine IL-1 alpha or human IL-1 receptor (IL-1R) antagonist.	propeptide	100-110	interleukin 1 beta	Homo sapiens	90-99
1748714-5	1991	When cultures were treated with both IL-1 beta and the cyclooxygenase inhibitor, indomethacin, the expression of alpha 2-, alpha 5-, and alpha v-subunit mRNA levels were dramatically increased relative to untreated controls; co-treatment with 0.5 mM prostaglandin E2 (PGE2) partially reversed this effect.	Dinoprostone	250-266	interleukin 1 beta	Homo sapiens	37-46
1748714-5	1991	When cultures were treated with both IL-1 beta and the cyclooxygenase inhibitor, indomethacin, the expression of alpha 2-, alpha 5-, and alpha v-subunit mRNA levels were dramatically increased relative to untreated controls; co-treatment with 0.5 mM prostaglandin E2 (PGE2) partially reversed this effect.	Dinoprostone	268-272	interleukin 1 beta	Homo sapiens	37-46
1748714-7	1991	Treatment with IL-1 beta or IL-1 beta + indomethacin also induced significant changes in MG-63 morphology (i.e., increased cell elongation) and increased the ability of cells to contract collagen gels.	Indomethacin	40-52	interleukin 1 beta	Homo sapiens	28-37
1748714-9	1991	These findings indicate that (a) IL-1 beta differentially regulates the expression of integrins and (b) that PGE2, which is induced by IL-1 beta, may provide a negative feedback loop which counteracts the stimulatory effect of IL-1 beta on integrin gene expression.	Dinoprostone	109-113	interleukin 1 beta	Homo sapiens	33-42
1748714-9	1991	These findings indicate that (a) IL-1 beta differentially regulates the expression of integrins and (b) that PGE2, which is induced by IL-1 beta, may provide a negative feedback loop which counteracts the stimulatory effect of IL-1 beta on integrin gene expression.	Dinoprostone	109-113	interleukin 1 beta	Homo sapiens	135-144
1748714-9	1991	These findings indicate that (a) IL-1 beta differentially regulates the expression of integrins and (b) that PGE2, which is induced by IL-1 beta, may provide a negative feedback loop which counteracts the stimulatory effect of IL-1 beta on integrin gene expression.	Dinoprostone	109-113	interleukin 1 beta	Homo sapiens	135-144
1919001-0	1991	IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.	Aspartic Acid	32-45	interleukin 1 beta	Homo sapiens	77-86
1919001-6	1991	Analysis of human IL-1 beta precursor mutants containing amino acid substitutions or deletions within each processing site demonstrated that omission or replacement of Asp at site 1 or site 2 prevented cleavage by ICE.	Aspartic Acid	168-171	interleukin 1 beta	Homo sapiens	18-27
1839507-6	1991	The IL-1 binding factor could be eliminated from plasma by incubation with protein A-Sepharose, suggesting that it consisted in IgG antibodies directed against IL-1.	Sepharose	85-94	interleukin 1 beta	Homo sapiens	4-8
1919001-12	1991	These results show that ICE is a highly specific IL-1 beta convertase with absolute requirements for Asp in P1 and a small hydrophobic amino acid in P1".	Aspartic Acid	101-104	interleukin 1 beta	Homo sapiens	49-58
1918980-8	1991	To determine if protein synthesis was required for induction of Il-1 beta gene expression, we treated PMN simultaneously with cytokines and cycloheximide, and found that cycloheximide enhanced the accumulation of Il-1-induced Il-1 beta mRNA, but abrogated the accumulation of Il-1 beta mRNA, by TNF- or TNF plus Il-1-treated PMN.	Cycloheximide	140-153	interleukin 1 beta	Homo sapiens	213-217
1839507-6	1991	The IL-1 binding factor could be eliminated from plasma by incubation with protein A-Sepharose, suggesting that it consisted in IgG antibodies directed against IL-1.	Sepharose	85-94	interleukin 1 beta	Homo sapiens	160-164
1717079-13	1991	Moreover, pretreatment of HUVECs with IL-1 beta increased prostacyclin (PGI2) production in response to a second stimulation by IL-1 beta, although such cells were unable to reexpress TF under the same conditions.	Epoprostenol	58-70	interleukin 1 beta	Homo sapiens	38-47
1717079-13	1991	Moreover, pretreatment of HUVECs with IL-1 beta increased prostacyclin (PGI2) production in response to a second stimulation by IL-1 beta, although such cells were unable to reexpress TF under the same conditions.	Epoprostenol	58-70	interleukin 1 beta	Homo sapiens	128-137
1717079-13	1991	Moreover, pretreatment of HUVECs with IL-1 beta increased prostacyclin (PGI2) production in response to a second stimulation by IL-1 beta, although such cells were unable to reexpress TF under the same conditions.	Epoprostenol	72-76	interleukin 1 beta	Homo sapiens	38-47
1717079-13	1991	Moreover, pretreatment of HUVECs with IL-1 beta increased prostacyclin (PGI2) production in response to a second stimulation by IL-1 beta, although such cells were unable to reexpress TF under the same conditions.	Epoprostenol	72-76	interleukin 1 beta	Homo sapiens	128-137
1717079-14	1991	This result suggests that distinct secondary messenger pathways are involved in TF induction and PGI2 synthesis by IL-1 beta in HUVECs.	Epoprostenol	97-101	interleukin 1 beta	Homo sapiens	115-124
1661797-4	1991	Treatment with purified human monocyte interleukin-1 beta, partially purified lapine, synovial IL-1 or phorbol myristate acetate strongly induced the synthesis of all these enzymes.	Tetradecanoylphorbol Acetate	103-128	interleukin 1 beta	Homo sapiens	39-57
1722831-1	1991	We studied the effects of recombinant human interleukin-1 beta (rhIL-1 beta) pretreatment on bleomycin (BLM)-induced pneumonitis in mice.	Bleomycin	93-102	interleukin 1 beta	Homo sapiens	44-62
1656470-4	1991	Specifically, opioids, including 2-n-pentyloxy-2-phenyl-4-methyl-morpholine, naloxone, and beta-endorphin, have been shown to interact with IL-2 receptors (134) and regulate production of IL-1 and IL-2 (48-50, 135).	2-n-pentyloxy-2-phenyl-4-methylmorpholine	33-75	interleukin 1 beta	Homo sapiens	188-192
1656470-4	1991	Specifically, opioids, including 2-n-pentyloxy-2-phenyl-4-methyl-morpholine, naloxone, and beta-endorphin, have been shown to interact with IL-2 receptors (134) and regulate production of IL-1 and IL-2 (48-50, 135).	Naloxone	77-85	interleukin 1 beta	Homo sapiens	188-192
1925598-0	1991	Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta.	Dioxins	12-18	interleukin 1 beta	Homo sapiens	68-86
1918980-8	1991	To determine if protein synthesis was required for induction of Il-1 beta gene expression, we treated PMN simultaneously with cytokines and cycloheximide, and found that cycloheximide enhanced the accumulation of Il-1-induced Il-1 beta mRNA, but abrogated the accumulation of Il-1 beta mRNA, by TNF- or TNF plus Il-1-treated PMN.	Cycloheximide	170-183	interleukin 1 beta	Homo sapiens	64-73
1918980-8	1991	To determine if protein synthesis was required for induction of Il-1 beta gene expression, we treated PMN simultaneously with cytokines and cycloheximide, and found that cycloheximide enhanced the accumulation of Il-1-induced Il-1 beta mRNA, but abrogated the accumulation of Il-1 beta mRNA, by TNF- or TNF plus Il-1-treated PMN.	Cycloheximide	170-183	interleukin 1 beta	Homo sapiens	64-68
1918980-8	1991	To determine if protein synthesis was required for induction of Il-1 beta gene expression, we treated PMN simultaneously with cytokines and cycloheximide, and found that cycloheximide enhanced the accumulation of Il-1-induced Il-1 beta mRNA, but abrogated the accumulation of Il-1 beta mRNA, by TNF- or TNF plus Il-1-treated PMN.	Cycloheximide	170-183	interleukin 1 beta	Homo sapiens	226-235
1918980-8	1991	To determine if protein synthesis was required for induction of Il-1 beta gene expression, we treated PMN simultaneously with cytokines and cycloheximide, and found that cycloheximide enhanced the accumulation of Il-1-induced Il-1 beta mRNA, but abrogated the accumulation of Il-1 beta mRNA, by TNF- or TNF plus Il-1-treated PMN.	Cycloheximide	170-183	interleukin 1 beta	Homo sapiens	226-235
1918980-8	1991	To determine if protein synthesis was required for induction of Il-1 beta gene expression, we treated PMN simultaneously with cytokines and cycloheximide, and found that cycloheximide enhanced the accumulation of Il-1-induced Il-1 beta mRNA, but abrogated the accumulation of Il-1 beta mRNA, by TNF- or TNF plus Il-1-treated PMN.	Cycloheximide	170-183	interleukin 1 beta	Homo sapiens	213-217
1746291-6	1991	Dexamethasone administration significantly suppressed the lectin-induced blastogenesis and the Il-1 beta production rate in normal volunteers, whereas depressives exhibited dexamethasone nonsuppression in those factors.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	95-104
1928366-0	1991	Colchicine has opposite effects on interleukin-1 beta and tumor necrosis factor-alpha production.	Colchicine	0-10	interleukin 1 beta	Homo sapiens	35-85
1681733-6	1991	In keeping with these biological activities and protein data, Northern blot analysis of total cellular RNA extracted from keratinocyte monolayers hybridized with a 32P-labelled 1-kb cDNA to IL-8 mRNA, revealed induction of the IL-8 gene in the presence of TNF-alpha and IL-1 beta, but not IFN-gamma.	Phosphorus-32	164-167	interleukin 1 beta	Homo sapiens	270-279
1928366-4	1991	Although colchicine resulted in a statistically significant increase in LPS-stimulated human alveolar macrophage IL-1 beta release, the increase was not as great as that observed with monocytes.	lps	72-75	interleukin 1 beta	Homo sapiens	113-122
1928366-5	1991	Northern blot analysis suggested that the colchicine effect occurs pretranslationally because colchicine caused an increase in LPS-stimulated IL-1 beta mRNA levels and a decrease in TNF-alpha mRNA levels.	Colchicine	42-52	interleukin 1 beta	Homo sapiens	142-151
1928366-5	1991	Northern blot analysis suggested that the colchicine effect occurs pretranslationally because colchicine caused an increase in LPS-stimulated IL-1 beta mRNA levels and a decrease in TNF-alpha mRNA levels.	Colchicine	94-104	interleukin 1 beta	Homo sapiens	142-151
1928366-5	1991	Northern blot analysis suggested that the colchicine effect occurs pretranslationally because colchicine caused an increase in LPS-stimulated IL-1 beta mRNA levels and a decrease in TNF-alpha mRNA levels.	lps	127-130	interleukin 1 beta	Homo sapiens	142-151
1928366-1	1991	To study the role of microtubules in cytokine production, the effect of the microtubule depolymerizing agent colchicine on lipopolysaccharide endotoxin (LPS)-induced interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) release by blood monocytes and alveolar macrophages were examined.	Colchicine	109-119	interleukin 1 beta	Homo sapiens	166-184
1928366-1	1991	To study the role of microtubules in cytokine production, the effect of the microtubule depolymerizing agent colchicine on lipopolysaccharide endotoxin (LPS)-induced interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) release by blood monocytes and alveolar macrophages were examined.	lipopolysaccharide endotoxin	123-151	interleukin 1 beta	Homo sapiens	166-184
1759822-3	1991	We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha production by human monocytes stimulated with lipopolysaccharide.	Erythromycin	85-97	interleukin 1 beta	Homo sapiens	173-182
1928366-1	1991	To study the role of microtubules in cytokine production, the effect of the microtubule depolymerizing agent colchicine on lipopolysaccharide endotoxin (LPS)-induced interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) release by blood monocytes and alveolar macrophages were examined.	lps	153-156	interleukin 1 beta	Homo sapiens	166-184
1928366-3	1991	Colchicine resulted in approximately 50% increase in LPS-induced IL-1 beta release and a 50% decrease in LPS-induced TNF-alpha release by human monocytes at all doses of LPS tested.	Colchicine	0-10	interleukin 1 beta	Homo sapiens	65-74
1928366-3	1991	Colchicine resulted in approximately 50% increase in LPS-induced IL-1 beta release and a 50% decrease in LPS-induced TNF-alpha release by human monocytes at all doses of LPS tested.	lps	53-56	interleukin 1 beta	Homo sapiens	65-74
1928366-4	1991	Although colchicine resulted in a statistically significant increase in LPS-stimulated human alveolar macrophage IL-1 beta release, the increase was not as great as that observed with monocytes.	Colchicine	9-19	interleukin 1 beta	Homo sapiens	113-122
1797949-1	1991	A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors.	Tetradecanoylphorbol Acetate	58-83	interleukin 1 beta	Homo sapiens	182-200
1940439-3	1991	We found that rhIL-6 mimicked some of the activities of IL-1 beta, as 24-96-h treatment of confluent fibroblast cultures with rhIL-6 caused concentration (10 to 1000 ng/ml)-dependent increases in the production of collagen and the glycosaminoglycans (GAG), hyaluronic acid and chondroitin-4/6-sulfates, but had little effect on fibronectin or total protein production.	Glycosaminoglycans	231-249	interleukin 1 beta	Homo sapiens	56-65
1940439-3	1991	We found that rhIL-6 mimicked some of the activities of IL-1 beta, as 24-96-h treatment of confluent fibroblast cultures with rhIL-6 caused concentration (10 to 1000 ng/ml)-dependent increases in the production of collagen and the glycosaminoglycans (GAG), hyaluronic acid and chondroitin-4/6-sulfates, but had little effect on fibronectin or total protein production.	Glycosaminoglycans	251-254	interleukin 1 beta	Homo sapiens	56-65
1940439-3	1991	We found that rhIL-6 mimicked some of the activities of IL-1 beta, as 24-96-h treatment of confluent fibroblast cultures with rhIL-6 caused concentration (10 to 1000 ng/ml)-dependent increases in the production of collagen and the glycosaminoglycans (GAG), hyaluronic acid and chondroitin-4/6-sulfates, but had little effect on fibronectin or total protein production.	Hyaluronic Acid	257-272	interleukin 1 beta	Homo sapiens	56-65
1940439-3	1991	We found that rhIL-6 mimicked some of the activities of IL-1 beta, as 24-96-h treatment of confluent fibroblast cultures with rhIL-6 caused concentration (10 to 1000 ng/ml)-dependent increases in the production of collagen and the glycosaminoglycans (GAG), hyaluronic acid and chondroitin-4/6-sulfates, but had little effect on fibronectin or total protein production.	chondroitin-4/6-sulfates	277-301	interleukin 1 beta	Homo sapiens	56-65
1661739-7	1991	Furthermore, IL-1 beta production was elevated to a lesser extent by the addition of increasing concentrations of the protein kinase C activator phorbol myristate acetate or by low concentration (0.001 microgram/ml) of PGE2.	myristate acetate	153-170	interleukin 1 beta	Homo sapiens	13-22
1661739-7	1991	Furthermore, IL-1 beta production was elevated to a lesser extent by the addition of increasing concentrations of the protein kinase C activator phorbol myristate acetate or by low concentration (0.001 microgram/ml) of PGE2.	Dinoprostone	219-223	interleukin 1 beta	Homo sapiens	13-22
1661739-10	1991	Together with the results obtained with phorbol myristate acetate, these data suggest that protein kinase C may play a role in the upregulation of IL-1 beta expression in normal skin fibroblasts.	Tetradecanoylphorbol Acetate	40-65	interleukin 1 beta	Homo sapiens	147-156
1797949-1	1991	A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors.	Tetradecanoylphorbol Acetate	85-88	interleukin 1 beta	Homo sapiens	182-200
1768743-3	1991	However, treatment of these cells with phorbol myristate acetate (PMA) resulted in the expression of IL-1 beta mRNA.	Tetradecanoylphorbol Acetate	39-64	interleukin 1 beta	Homo sapiens	101-110
1745007-1	1991	Interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF) have been reported to stimulate human mesangial cells (HMC) to proliferate and synthesize eicosanoids.	Eicosanoids	153-164	interleukin 1 beta	Homo sapiens	0-18
1745007-1	1991	Interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF) have been reported to stimulate human mesangial cells (HMC) to proliferate and synthesize eicosanoids.	Eicosanoids	153-164	interleukin 1 beta	Homo sapiens	20-29
1768743-3	1991	However, treatment of these cells with phorbol myristate acetate (PMA) resulted in the expression of IL-1 beta mRNA.	Tetradecanoylphorbol Acetate	66-69	interleukin 1 beta	Homo sapiens	101-110
1768743-4	1991	Likewise, treatment of PBM with phorbol dibutyrate (PdBu), phorbol diacetate (PDA), or mezerein, which, similar to PMA, were able to induce the translocation of protein kinase C (PKc) to the monocyte plasma membrane, resulted in predominantly IL-1 beta mRNA expression.	2,3-piperidinedicarboxylic acid	78-81	interleukin 1 beta	Homo sapiens	243-252
1768743-4	1991	Likewise, treatment of PBM with phorbol dibutyrate (PdBu), phorbol diacetate (PDA), or mezerein, which, similar to PMA, were able to induce the translocation of protein kinase C (PKc) to the monocyte plasma membrane, resulted in predominantly IL-1 beta mRNA expression.	pbm	23-26	interleukin 1 beta	Homo sapiens	243-252
1768743-4	1991	Likewise, treatment of PBM with phorbol dibutyrate (PdBu), phorbol diacetate (PDA), or mezerein, which, similar to PMA, were able to induce the translocation of protein kinase C (PKc) to the monocyte plasma membrane, resulted in predominantly IL-1 beta mRNA expression.	Phorbol 12,13-Dibutyrate	32-50	interleukin 1 beta	Homo sapiens	243-252
1768743-4	1991	Likewise, treatment of PBM with phorbol dibutyrate (PdBu), phorbol diacetate (PDA), or mezerein, which, similar to PMA, were able to induce the translocation of protein kinase C (PKc) to the monocyte plasma membrane, resulted in predominantly IL-1 beta mRNA expression.	Phorbol 12,13-Dibutyrate	52-56	interleukin 1 beta	Homo sapiens	243-252
1768743-4	1991	Likewise, treatment of PBM with phorbol dibutyrate (PdBu), phorbol diacetate (PDA), or mezerein, which, similar to PMA, were able to induce the translocation of protein kinase C (PKc) to the monocyte plasma membrane, resulted in predominantly IL-1 beta mRNA expression.	Phorbol 13,20-diacetate	59-76	interleukin 1 beta	Homo sapiens	243-252
1768743-4	1991	Likewise, treatment of PBM with phorbol dibutyrate (PdBu), phorbol diacetate (PDA), or mezerein, which, similar to PMA, were able to induce the translocation of protein kinase C (PKc) to the monocyte plasma membrane, resulted in predominantly IL-1 beta mRNA expression.	mezerein	87-95	interleukin 1 beta	Homo sapiens	243-252
1656517-0	1991	Dietary supplementation with omega-3-polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-1 beta content but not monokine secretion in healthy and insulin-dependent diabetic individuals.	omega-3-polyunsaturated fatty acids	29-64	interleukin 1 beta	Homo sapiens	110-128
1665294-1	1991	Aminophenyl mercuric acetate (APMA)-activated collagenase (C) (60 U/ml) obtained from in vitro cultures of human skin fibroblasts or recombinant interleukin-1 beta (IL-1 beta) (200 U/ml) was infused continuously for 7 days into the rabbit knee synovial space by means of an implanted Alzet osmotic pump.	aminophenyl mercuric acetate	0-28	interleukin 1 beta	Homo sapiens	165-174
1665294-1	1991	Aminophenyl mercuric acetate (APMA)-activated collagenase (C) (60 U/ml) obtained from in vitro cultures of human skin fibroblasts or recombinant interleukin-1 beta (IL-1 beta) (200 U/ml) was infused continuously for 7 days into the rabbit knee synovial space by means of an implanted Alzet osmotic pump.	N-(3-Aminopropyl)methacrylamide	30-34	interleukin 1 beta	Homo sapiens	145-163
1665294-1	1991	Aminophenyl mercuric acetate (APMA)-activated collagenase (C) (60 U/ml) obtained from in vitro cultures of human skin fibroblasts or recombinant interleukin-1 beta (IL-1 beta) (200 U/ml) was infused continuously for 7 days into the rabbit knee synovial space by means of an implanted Alzet osmotic pump.	N-(3-Aminopropyl)methacrylamide	30-34	interleukin 1 beta	Homo sapiens	165-174
1790636-5	1991	GM-CSF stimulated the proliferation of synovial cells and its effect was enhanced by the presence of indomethacin, like that of a potent stimulator of synovial cells, interleukin-1 beta (IL-1 beta).	Indomethacin	101-113	interleukin 1 beta	Homo sapiens	187-196
1831680-7	1991	Rocking endotoxin-stimulated PBMC produced 75% less IL-1ra but the same amount of IL-1 beta when compared with PBMC cultured in stationary plastic tubes.	PBMC	29-33	interleukin 1 beta	Homo sapiens	82-91
1874173-10	1991	IL-1 beta inhibited hCG-stimulated testosterone formation and P450scc mRNA expression in a dose-dependent manner.	Testosterone	35-47	interleukin 1 beta	Homo sapiens	0-9
1714478-4	1991	Increased levels of the CSF Ag were detected after 2 to 8 h stimulation with IL-1, and the optimum dose of IL-1 was 10 to 100 U/ml (0.06 to 0.6 nM IL-1 alpha; 0.02 to 0.2 nM IL-1 beta); neither CSF was detectable in nonstimulated cultures nor in IL-1-stimulated cultures treated with actinomycin D or cycloheximide, indicating the requirement for de novo RNA and protein synthesis.	Dactinomycin	284-297	interleukin 1 beta	Homo sapiens	107-111
1856599-6	1991	Antigenic and bioactive IL-8 were significantly apparent by 4-8 h, respectively, and increased significantly to maximal levels by 24 h. Furthermore, adherent PBMC IL-8 gene expression was suppressed by either concomitant treatment with actinomycin-D or cycloheximide, yet specific neutralizing antibodies directed against either IL-1 beta or tumor necrosis factor (TNF)-alpha failed to alter adherence-induced steady-state IL-8 mRNA levels.	Dactinomycin	236-249	interleukin 1 beta	Homo sapiens	329-338
1856599-6	1991	Antigenic and bioactive IL-8 were significantly apparent by 4-8 h, respectively, and increased significantly to maximal levels by 24 h. Furthermore, adherent PBMC IL-8 gene expression was suppressed by either concomitant treatment with actinomycin-D or cycloheximide, yet specific neutralizing antibodies directed against either IL-1 beta or tumor necrosis factor (TNF)-alpha failed to alter adherence-induced steady-state IL-8 mRNA levels.	Cycloheximide	253-266	interleukin 1 beta	Homo sapiens	329-338
1954699-3	1991	IL-1 beta was found to depress 35S-proteoglycan synthesis rates and to enhance prostaglandin E2 (PGE2) production in these monolayer cultured chondrocytes.	Sulfur-35	31-34	interleukin 1 beta	Homo sapiens	0-9
1954699-3	1991	IL-1 beta was found to depress 35S-proteoglycan synthesis rates and to enhance prostaglandin E2 (PGE2) production in these monolayer cultured chondrocytes.	Dinoprostone	79-95	interleukin 1 beta	Homo sapiens	0-9
1954699-3	1991	IL-1 beta was found to depress 35S-proteoglycan synthesis rates and to enhance prostaglandin E2 (PGE2) production in these monolayer cultured chondrocytes.	Dinoprostone	97-101	interleukin 1 beta	Homo sapiens	0-9
1954699-4	1991	Induction of 35S-proteoglycan-degradative activity by these cells also occurred in IL-1 beta treated cultures.	Sulfur-35	13-16	interleukin 1 beta	Homo sapiens	83-92
1954699-6	1991	IL-1 beta increased 3H-thymidine incorporation rates in the "old" cultures.	3h-thymidine	20-32	interleukin 1 beta	Homo sapiens	0-9
1714478-4	1991	Increased levels of the CSF Ag were detected after 2 to 8 h stimulation with IL-1, and the optimum dose of IL-1 was 10 to 100 U/ml (0.06 to 0.6 nM IL-1 alpha; 0.02 to 0.2 nM IL-1 beta); neither CSF was detectable in nonstimulated cultures nor in IL-1-stimulated cultures treated with actinomycin D or cycloheximide, indicating the requirement for de novo RNA and protein synthesis.	Dactinomycin	284-297	interleukin 1 beta	Homo sapiens	107-111
1714478-4	1991	Increased levels of the CSF Ag were detected after 2 to 8 h stimulation with IL-1, and the optimum dose of IL-1 was 10 to 100 U/ml (0.06 to 0.6 nM IL-1 alpha; 0.02 to 0.2 nM IL-1 beta); neither CSF was detectable in nonstimulated cultures nor in IL-1-stimulated cultures treated with actinomycin D or cycloheximide, indicating the requirement for de novo RNA and protein synthesis.	Cycloheximide	301-314	interleukin 1 beta	Homo sapiens	107-111
1872826-2	1991	We investigated the effect of chemically synthesized substances, 1,1"-ethylidene bis[tryptophan] (EBT) and its decomposition product, 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA) recently identified in the implicated LT, on the eosinophil differentiation and the induction of IL-1 and IL-6.	1,1'-ethylidene bis(tryptophan)	98-101	interleukin 1 beta	Homo sapiens	299-303
1714478-4	1991	Increased levels of the CSF Ag were detected after 2 to 8 h stimulation with IL-1, and the optimum dose of IL-1 was 10 to 100 U/ml (0.06 to 0.6 nM IL-1 alpha; 0.02 to 0.2 nM IL-1 beta); neither CSF was detectable in nonstimulated cultures nor in IL-1-stimulated cultures treated with actinomycin D or cycloheximide, indicating the requirement for de novo RNA and protein synthesis.	Cycloheximide	301-314	interleukin 1 beta	Homo sapiens	107-111
1714478-5	1991	The IL-1-mediated increase in GM-CSF could also be inhibited by the corticosteroid, dexamethasone, but not by the cyclo-oxygenase inhibitor, indomethacin.	Dexamethasone	84-97	interleukin 1 beta	Homo sapiens	4-8
1917593-7	1991	Actinomycin D suppressed the endogeneous and rIL-1-induced IL-1 mRNA expression Indomethacin, in the presence of rIL-1 alpha or beta, up-regulates the level of expression of IL-1 beta in ASLCs pretreated with rIFN gamma, but has the opposite effect in non-pretreated cells.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	46-50
1930911-4	1991	IL-1, IL-6 and TNF-alpha have several functions which suggest that they participate in the chronic disease process of rheumatoid arthritis, such as increasing production of eicosanoid, collagenase and prostaglandin E2.	Eicosanoids	173-183	interleukin 1 beta	Homo sapiens	0-4
1930911-4	1991	IL-1, IL-6 and TNF-alpha have several functions which suggest that they participate in the chronic disease process of rheumatoid arthritis, such as increasing production of eicosanoid, collagenase and prostaglandin E2.	Dinoprostone	201-217	interleukin 1 beta	Homo sapiens	0-4
1864014-2	1991	After 7 days of ciprofloxacin, the extracellular and cellular production of TNF-alpha, the cellular production of IL-1 activity, the extracellular and cellular production of IL-1 alpha, and the cellular production of IL-6 increased significantly.	Ciprofloxacin	16-29	interleukin 1 beta	Homo sapiens	114-118
1864014-0	1991	Ciprofloxacin treatment in vivo increases the ex vivo capacity of lipopolysaccharide-stimulated human monocytes to produce IL-1, IL-6 and tumour necrosis factor-alpha.	Ciprofloxacin	0-13	interleukin 1 beta	Homo sapiens	123-127
1917593-7	1991	Actinomycin D suppressed the endogeneous and rIL-1-induced IL-1 mRNA expression Indomethacin, in the presence of rIL-1 alpha or beta, up-regulates the level of expression of IL-1 beta in ASLCs pretreated with rIFN gamma, but has the opposite effect in non-pretreated cells.	Dactinomycin	0-13	interleukin 1 beta	Homo sapiens	174-183
1917593-7	1991	Actinomycin D suppressed the endogeneous and rIL-1-induced IL-1 mRNA expression Indomethacin, in the presence of rIL-1 alpha or beta, up-regulates the level of expression of IL-1 beta in ASLCs pretreated with rIFN gamma, but has the opposite effect in non-pretreated cells.	Indomethacin	80-92	interleukin 1 beta	Homo sapiens	46-50
1917593-7	1991	Actinomycin D suppressed the endogeneous and rIL-1-induced IL-1 mRNA expression Indomethacin, in the presence of rIL-1 alpha or beta, up-regulates the level of expression of IL-1 beta in ASLCs pretreated with rIFN gamma, but has the opposite effect in non-pretreated cells.	Indomethacin	80-92	interleukin 1 beta	Homo sapiens	174-183
1646841-0	1991	Retinoic acid enhances IL-1 beta expression in myeloid leukemia cells and in human monocytes.	Tretinoin	0-13	interleukin 1 beta	Homo sapiens	23-32
2071932-7	1991	In addition, preincubation of DMEC with TGF-beta completely blocked their response to the stimulating effects of TNF-alpha, IL-1-beta, or both cytokines.	dmec	30-34	interleukin 1 beta	Homo sapiens	124-133
2071932-8	1991	Furthermore, TGF-beta also abrogated the enhanced adhesiveness of DMEC pretreated with TNF-alpha and IL-1-beta.	dmec	66-70	interleukin 1 beta	Homo sapiens	101-110
1894750-1	1991	Interleukin 1 beta is a potent bone resorptive cytokine which also mediates soft tissue destruction through the stimulation of prostaglandin production, and the induction of collagenase and other proteases.	Prostaglandins	127-140	interleukin 1 beta	Homo sapiens	0-18
2065892-3	1991	In the present study, using the young rat model, recombinant human IL 1 beta produced excellent protection from cytosine arabinoside-induced alopecia.	Cytarabine	112-132	interleukin 1 beta	Homo sapiens	67-76
1711077-10	1991	IL-1 beta-pretreated basophils released minimal amounts of histamine in response to PAF.	Histamine	59-68	interleukin 1 beta	Homo sapiens	0-9
1646841-1	1991	We have examined the role of retinoic acid (RA), the biologically active metabolite of vitamin A, in expression of the IL-1 beta gene in the human myeloid leukemia cell line THP-1 and in human monocytes.	Tretinoin	29-42	interleukin 1 beta	Homo sapiens	119-128
1646841-1	1991	We have examined the role of retinoic acid (RA), the biologically active metabolite of vitamin A, in expression of the IL-1 beta gene in the human myeloid leukemia cell line THP-1 and in human monocytes.	Tretinoin	44-46	interleukin 1 beta	Homo sapiens	119-128
1646841-1	1991	We have examined the role of retinoic acid (RA), the biologically active metabolite of vitamin A, in expression of the IL-1 beta gene in the human myeloid leukemia cell line THP-1 and in human monocytes.	Vitamin A	87-96	interleukin 1 beta	Homo sapiens	119-128
1646841-2	1991	Both protein kinase C-activating phorbol esters, e.g., PMA, and LPS induce IL-1 beta expression in these cells.	Phorbol Esters	33-47	interleukin 1 beta	Homo sapiens	75-84
1717702-4	1991	Depolarizing agents, interferon-gamma, glucocorticoid hormones, and prostaglandin synthesis inhibitors all diminish the induction of SP and PPT mRNA by IL-1.	Prostaglandins	68-81	interleukin 1 beta	Homo sapiens	152-156
1646841-2	1991	Both protein kinase C-activating phorbol esters, e.g., PMA, and LPS induce IL-1 beta expression in these cells.	Tetradecanoylphorbol Acetate	55-58	interleukin 1 beta	Homo sapiens	75-84
1646841-3	1991	Physiologic RA concentrations alone were not able to induce any IL-1 beta production, but they strongly enhanced the PMA-induced IL-1 beta protein production and mRNA accumulation in both human monocytes and in THP-1 cells.	Tretinoin	12-14	interleukin 1 beta	Homo sapiens	129-138
1646841-5	1991	RA also slightly potentiated LPS-induced IL-1 beta expression in THP-1 cells but not in human monocytes.	Tretinoin	0-2	interleukin 1 beta	Homo sapiens	41-50
1946245-3	1991	In the present study we examined the effect of interleukin-1 beta (IL-1 beta), tumor necrosis factor (TNF), and endotoxin on prostaglandin production by chorion laeve cells.	Prostaglandins	125-138	interleukin 1 beta	Homo sapiens	47-65
1838083-5	1991	Similar to that reported previously, IL-1 beta caused a dose-dependent inhibition of hCG-induced testosterone.	Testosterone	97-109	interleukin 1 beta	Homo sapiens	37-46
1946245-3	1991	In the present study we examined the effect of interleukin-1 beta (IL-1 beta), tumor necrosis factor (TNF), and endotoxin on prostaglandin production by chorion laeve cells.	Prostaglandins	125-138	interleukin 1 beta	Homo sapiens	67-76
2053589-3	1991	Subsequent in situ hybridization using 35S-labeled synthetic oligonucleotide probes complementary to human IL-1 alpha and IL-1 beta mRNA showed IL-1 transcripts in macrophages predominantly but not in T cells or B cells.	Sulfur-35	39-42	interleukin 1 beta	Homo sapiens	122-131
1648785-0	1991	Cyclic adenosine monophosphate decreases the secretion, but not the cell-associated levels, of interleukin-1 beta in lipopolysaccharide-activated human monocytes.	Cyclic AMP	0-30	interleukin 1 beta	Homo sapiens	95-113
1648785-2	1991	Elevation of intracellular cyclic adenosine monophosphate (cAMP) is considered an important down-regulative signal in the production of IL-1 beta in lipopolysaccharide (LPS)-induced monocytes.	Cyclic AMP	27-57	interleukin 1 beta	Homo sapiens	136-145
1648785-2	1991	Elevation of intracellular cyclic adenosine monophosphate (cAMP) is considered an important down-regulative signal in the production of IL-1 beta in lipopolysaccharide (LPS)-induced monocytes.	Cyclic AMP	59-63	interleukin 1 beta	Homo sapiens	136-145
1648785-3	1991	In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged.	Cyclic AMP	70-74	interleukin 1 beta	Homo sapiens	196-205
1648785-3	1991	In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged.	Cyclic AMP	70-74	interleukin 1 beta	Homo sapiens	230-239
1648785-3	1991	In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged.	Dinoprostone	109-125	interleukin 1 beta	Homo sapiens	196-205
1648785-3	1991	In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged.	Dinoprostone	109-125	interleukin 1 beta	Homo sapiens	230-239
1648785-3	1991	In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged.	Colforsin	127-136	interleukin 1 beta	Homo sapiens	196-205
1905495-9	1991	Urinary 3-methylhistidine excretion correlated with mononuclear cell secretion of both IL-1 beta (P less than 0.05) and prostaglandin E2 (P less than 0.05), supporting the concept that these mononuclear cell products contribute to the regulation of muscle proteolysis.	3-methylhistidine	8-25	interleukin 1 beta	Homo sapiens	87-96
1648785-3	1991	In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged.	Bucladesine	140-159	interleukin 1 beta	Homo sapiens	196-205
1648785-3	1991	In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged.	Bucladesine	140-159	interleukin 1 beta	Homo sapiens	230-239
1903934-0	1991	Interleukin-1 beta-induced changes in the kinetic constants of L-proline uptake in human skin fibroblasts.	Proline	63-72	interleukin 1 beta	Homo sapiens	0-18
1903934-1	1991	The effects of interleukin-1 beta (IL-1) on L-proline uptake in human skin fibroblasts were investigated.	Proline	44-53	interleukin 1 beta	Homo sapiens	15-33
1903934-1	1991	The effects of interleukin-1 beta (IL-1) on L-proline uptake in human skin fibroblasts were investigated.	Proline	44-53	interleukin 1 beta	Homo sapiens	35-39
1903934-6	1991	To determine whether IL-1-induced prostaglandin release influences proline uptake, indomethacin (14 microM) was added as a cyclo-oxygenase inhibitor.	Prostaglandins	34-47	interleukin 1 beta	Homo sapiens	21-25
1903934-6	1991	To determine whether IL-1-induced prostaglandin release influences proline uptake, indomethacin (14 microM) was added as a cyclo-oxygenase inhibitor.	Proline	67-74	interleukin 1 beta	Homo sapiens	21-25
1903934-8	1991	When IL-1 was tested in the presence of indomethacin, the inhibition of L-proline uptake was still observed, with values between those obtained with each substance in isolation.	Indomethacin	40-52	interleukin 1 beta	Homo sapiens	5-9
1903934-8	1991	When IL-1 was tested in the presence of indomethacin, the inhibition of L-proline uptake was still observed, with values between those obtained with each substance in isolation.	Proline	72-81	interleukin 1 beta	Homo sapiens	5-9
2026872-5	1991	The initial 2 to 3 h lag period may be necessary for production of a protein(s) that mediates this inhibitory effect because treatment with the protein synthesis inhibitor, cycloheximide, blocked the marked reduction of IL-1 message levels induced by IL-4.	Cycloheximide	173-186	interleukin 1 beta	Homo sapiens	220-224
1903934-9	1991	This suggests that the inhibitory effect of IL-1 on proline uptake by skin fibroblast does not only involve the prostaglandins that accumulate in the medium, but no firm conclusion can be drawn, due to the fact that the inhibition by the two agents was not statistically independent.	Proline	52-59	interleukin 1 beta	Homo sapiens	44-48
1903934-9	1991	This suggests that the inhibitory effect of IL-1 on proline uptake by skin fibroblast does not only involve the prostaglandins that accumulate in the medium, but no firm conclusion can be drawn, due to the fact that the inhibition by the two agents was not statistically independent.	Prostaglandins	112-126	interleukin 1 beta	Homo sapiens	44-48
1903934-11	1991	Therefore the two systems of proline uptake in skin fibroblasts are probably inhibited by IL-1 via different mechanisms.	Proline	29-36	interleukin 1 beta	Homo sapiens	90-94
1893073-2	1991	Recombinant interleukin-1-beta (IL-1-beta) and tumor necrosis factor-alpha (TNF-alpha) stimulated moderately the DNA synthesis and markedly the production of PGE2.	Dinoprostone	158-162	interleukin 1 beta	Homo sapiens	12-30
2025958-1	1991	Coumarin as well as its derivatives 7-OH coumarin and 4-OH coumarin were found to stimulate interleukin-1 beta (IL-1 beta) release from freshly isolated human mononuclear cells (MNC) if the culture medium contained fetal calf serum.	coumarin	0-8	interleukin 1 beta	Homo sapiens	92-110
2025958-1	1991	Coumarin as well as its derivatives 7-OH coumarin and 4-OH coumarin were found to stimulate interleukin-1 beta (IL-1 beta) release from freshly isolated human mononuclear cells (MNC) if the culture medium contained fetal calf serum.	coumarin	0-8	interleukin 1 beta	Homo sapiens	112-121
1893073-2	1991	Recombinant interleukin-1-beta (IL-1-beta) and tumor necrosis factor-alpha (TNF-alpha) stimulated moderately the DNA synthesis and markedly the production of PGE2.	Dinoprostone	158-162	interleukin 1 beta	Homo sapiens	32-41
1893073-5	1991	Incubation with a crude T cell supernatant or a mixture of cytokines including IL-1-beta, TNF-alpha and IFN-gamma enhanced synovial cell growth and PGE2 production as compared to the effect elicited by each single cytokine.	Dinoprostone	148-152	interleukin 1 beta	Homo sapiens	79-88
2025958-1	1991	Coumarin as well as its derivatives 7-OH coumarin and 4-OH coumarin were found to stimulate interleukin-1 beta (IL-1 beta) release from freshly isolated human mononuclear cells (MNC) if the culture medium contained fetal calf serum.	7-oh coumarin	36-49	interleukin 1 beta	Homo sapiens	92-110
2025958-1	1991	Coumarin as well as its derivatives 7-OH coumarin and 4-OH coumarin were found to stimulate interleukin-1 beta (IL-1 beta) release from freshly isolated human mononuclear cells (MNC) if the culture medium contained fetal calf serum.	7-oh coumarin	36-49	interleukin 1 beta	Homo sapiens	112-121
1893074-4	1991	Southern blot analyses of plasmids containing IL-1 beta and IL-8 gave positive results with the 3" degenerate probe, 5"-acr-dTATTTATTN, clearly showing that the very short probe approach can be used in this type of analysis.	5"-acr-dtatttattn	117-134	interleukin 1 beta	Homo sapiens	46-55
2025958-1	1991	Coumarin as well as its derivatives 7-OH coumarin and 4-OH coumarin were found to stimulate interleukin-1 beta (IL-1 beta) release from freshly isolated human mononuclear cells (MNC) if the culture medium contained fetal calf serum.	4-hydroxycoumarin	54-67	interleukin 1 beta	Homo sapiens	92-110
2025958-1	1991	Coumarin as well as its derivatives 7-OH coumarin and 4-OH coumarin were found to stimulate interleukin-1 beta (IL-1 beta) release from freshly isolated human mononuclear cells (MNC) if the culture medium contained fetal calf serum.	4-hydroxycoumarin	54-67	interleukin 1 beta	Homo sapiens	112-121
2013367-1	1991	The cytokine interleukin 1 beta is an important mediator of inflammatory processes capable of inducing eicosanoid production, T-cell activation, and increased vascular permeability.	Eicosanoids	103-113	interleukin 1 beta	Homo sapiens	13-31
2025958-3	1991	Therefore, the combined action of endotoxin and coumarin was tested on MNC IL-1 beta production.	coumarin	48-56	interleukin 1 beta	Homo sapiens	75-84
2025958-4	1991	The coumarins were able to potentiate human MNC IL-1 beta production by lipopolysaccharide (LPS) in a dose-dependent manner.	Coumarins	4-13	interleukin 1 beta	Homo sapiens	48-57
2025958-8	1991	In addition, both the total amount of MNC IL-1 beta (cell-associated + extracellular) and the extracellular portion of the cytokine were synergistically decreased if coumarin or its derivatives were added to endotoxin-stimulated cultures.	coumarin	166-174	interleukin 1 beta	Homo sapiens	42-51
2040654-0	1991	Role of putrescine in interleukin 1 beta production in human histiocytic lymphoma cell line U937.	Putrescine	8-18	interleukin 1 beta	Homo sapiens	22-40
1367530-6	1991	In contrast, SMS118(pSM320) was able to secrete 0.27 mg of natural IL-1 beta per g of cells (6.7 mg l-1 of culture).	sms118	13-19	interleukin 1 beta	Homo sapiens	67-76
1367530-6	1991	In contrast, SMS118(pSM320) was able to secrete 0.27 mg of natural IL-1 beta per g of cells (6.7 mg l-1 of culture).	psm320	20-26	interleukin 1 beta	Homo sapiens	67-76
2022738-0	1991	Temperature-dependent modulation of lipopolysaccharide-induced interleukin-1 beta and tumor necrosis factor alpha expression in cultured human astroglial cells by dexamethasone and indomethacin.	Dexamethasone	163-176	interleukin 1 beta	Homo sapiens	63-81
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	15-52	interleukin 1 beta	Homo sapiens	112-130
2022738-0	1991	Temperature-dependent modulation of lipopolysaccharide-induced interleukin-1 beta and tumor necrosis factor alpha expression in cultured human astroglial cells by dexamethasone and indomethacin.	Indomethacin	181-193	interleukin 1 beta	Homo sapiens	63-81
2022738-7	1991	The effects of another antiinflammatory agent, indomethacin, on LPS induction of IL-1 beta and TNF alpha mRNA were temperature and cell line dependent.	Indomethacin	47-59	interleukin 1 beta	Homo sapiens	81-90
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	15-52	interleukin 1 beta	Homo sapiens	132-141
2022738-3	1991	Dexamethasone treatment improves outcome in bacterial meningitis possibly by inhibiting IL-1 beta and TNF alpha.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	88-97
2022738-4	1991	In this report, the effects of elevated temperature and dexamethasone on LPS-stimulated IL-1 beta and TNF alpha mRNA gene expression and protein synthesis were studied in human astrocytoma cell lines and primary cultures of human fetal astrocytes.	Dexamethasone	56-69	interleukin 1 beta	Homo sapiens	88-97
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	54-57	interleukin 1 beta	Homo sapiens	112-130
2022738-5	1991	Cells cultured at 40 degrees C exhibited smaller peaks of IL-1 beta and TNF alpha transcription and protein synthesis compared with cells cultured at 37 degrees C. The addition of dexamethasone before, during, or after exposure of the cells to LPS resulted in temperature-dependent inhibition of IL-1 beta transcription and protein synthesis.	Dexamethasone	180-193	interleukin 1 beta	Homo sapiens	58-67
2040654-8	1991	DFMO decreased the cellular levels of putrescine and spermidine and suppressed IL-1 beta release and IL-1 beta mRNA expression by 65%.	Eflornithine	0-4	interleukin 1 beta	Homo sapiens	101-110
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	54-57	interleukin 1 beta	Homo sapiens	132-141
2040654-11	1991	These results thus suggest that changes in either of these intracellular polyamines, especially putrescine, help to regulate the differentiation of U937 cells, resulting in partial control of the regulation of IL-1 beta production.	Polyamines	73-83	interleukin 1 beta	Homo sapiens	210-219
2040654-11	1991	These results thus suggest that changes in either of these intracellular polyamines, especially putrescine, help to regulate the differentiation of U937 cells, resulting in partial control of the regulation of IL-1 beta production.	Putrescine	96-106	interleukin 1 beta	Homo sapiens	210-219
2022738-5	1991	Cells cultured at 40 degrees C exhibited smaller peaks of IL-1 beta and TNF alpha transcription and protein synthesis compared with cells cultured at 37 degrees C. The addition of dexamethasone before, during, or after exposure of the cells to LPS resulted in temperature-dependent inhibition of IL-1 beta transcription and protein synthesis.	Dexamethasone	180-193	interleukin 1 beta	Homo sapiens	296-305
2040654-2	1991	Here we investigated the effect of treatment with both TPA and 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) on LPS-induced IL-1 beta production in U937 cells.	Tetradecanoylphorbol Acetate	55-58	interleukin 1 beta	Homo sapiens	124-133
2040654-2	1991	Here we investigated the effect of treatment with both TPA and 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) on LPS-induced IL-1 beta production in U937 cells.	Calcitriol	96-107	interleukin 1 beta	Homo sapiens	124-133
2040654-4	1991	Combined treatment with TPA and 1,25(OH)2D3 for 72 h followed by incubation with LPS for 24 h caused synergistic induction of both IL-1 beta release and mRNA expression.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Homo sapiens	131-140
2040654-4	1991	Combined treatment with TPA and 1,25(OH)2D3 for 72 h followed by incubation with LPS for 24 h caused synergistic induction of both IL-1 beta release and mRNA expression.	Calcitriol	32-43	interleukin 1 beta	Homo sapiens	131-140
2040654-7	1991	To find whether these peaks were related to IL-1 beta production, DL-alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ODC, was added together with TPA and 1,25(OH)2D3.	Eflornithine	66-98	interleukin 1 beta	Homo sapiens	44-53
2040654-8	1991	DFMO decreased the cellular levels of putrescine and spermidine and suppressed IL-1 beta release and IL-1 beta mRNA expression by 65%.	Eflornithine	0-4	interleukin 1 beta	Homo sapiens	79-88
1903479-4	1991	In human lung fibroblasts and in human umbilical vein endothelial cells, LIF was constitutively expressed and its accumulation was increased in a time-dependent manner following treatment with the phorbol ester TPA and in the presence of the two immediate response cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1-beta.	Tetradecanoylphorbol Acetate	211-214	interleukin 1 beta	Homo sapiens	313-336
2051729-6	1991	IL-1 beta concentrations correlated directly with those of IL-2; IL-1 beta presence was associated with higher stimulation indices, higher mean concentrations of TNF alpha, IL-2, stromelysin, and PGE2, and with positive endotoxin assays, suggesting activation of the cytokine cascade in vivo.	Dinoprostone	196-200	interleukin 1 beta	Homo sapiens	65-74
2016316-5	1991	In addition, cysteine residues that are exposed to solvent in the IL-1 beta precursor become buried in the mature protein.	Cysteine	13-21	interleukin 1 beta	Homo sapiens	66-75
1649133-2	1991	IL-1 beta markedly enhanced PGE2 production in chondrocytes and, to the lesser extent, in synovial cells.	Dinoprostone	28-32	interleukin 1 beta	Homo sapiens	0-9
1649133-4	1991	IL-1 beta significantly suppressed the release of NAG and superoxide by synovial cells, whereas it significantly enhanced the production of NAG and superoxide by chondrocytes.	Superoxides	58-68	interleukin 1 beta	Homo sapiens	0-9
1649133-4	1991	IL-1 beta significantly suppressed the release of NAG and superoxide by synovial cells, whereas it significantly enhanced the production of NAG and superoxide by chondrocytes.	Superoxides	148-158	interleukin 1 beta	Homo sapiens	0-9
1883481-5	1991	Sephacryl S-200 chromatography showed that the molecular weight of this factor was approximately 17.5 kDa, and Western blot analysis revealed that this factor reacted with polyclonal anti-IL-1 beta antibody under the reduced condition.	sephacryl S 200	0-15	interleukin 1 beta	Homo sapiens	188-197
1649133-0	1991	Effects of recombinant human IL-1 beta on production of prostaglandin E2, leukotriene B4, NAG, and superoxide by human synovial cells and chondrocytes.	Superoxides	99-109	interleukin 1 beta	Homo sapiens	29-38
2007907-4	1991	The (n-3) fatty acid supplementation reduced total interleukin (IL)-1 beta synthesis by 48% in young women but by 90% in older women; tumor necrosis factor was reduced by 58% in young and 70% in older women.	Fatty Acids, Omega-3	4-20	interleukin 1 beta	Homo sapiens	51-74
1873357-6	1991	A modest dose of IL-1 beta (1 microgram/kg) was found to stimulate transient increases in serum calcium, and a persistent elevation of urinary calcium excretion.	Calcium	96-103	interleukin 1 beta	Homo sapiens	17-26
1873357-6	1991	A modest dose of IL-1 beta (1 microgram/kg) was found to stimulate transient increases in serum calcium, and a persistent elevation of urinary calcium excretion.	Calcium	143-150	interleukin 1 beta	Homo sapiens	17-26
1712069-0	1991	Covalent disulfide binding of human IL-1 beta to alpha 2-macroglobulin: inhibition by D-penicillamine.	Disulfides	9-18	interleukin 1 beta	Homo sapiens	36-45
1873357-7	1991	IL-1 beta treatment also resulted in decreases in serum iron levels and in the albumin/globulin ratio, well-established in vivo effects of IL-1.	Iron	56-60	interleukin 1 beta	Homo sapiens	0-9
1712069-0	1991	Covalent disulfide binding of human IL-1 beta to alpha 2-macroglobulin: inhibition by D-penicillamine.	Penicillamine	86-101	interleukin 1 beta	Homo sapiens	36-45
1712069-1	1991	Secreted human IL-1 beta is known to have two free SH groups due to unpaired cysteines (positions 8 and 71).	Cysteine	77-86	interleukin 1 beta	Homo sapiens	15-24
1712069-4	1991	Thus, the possibility that IL-1 beta forms a disulfide bond with alpha 2M was investigated.	Disulfides	45-54	interleukin 1 beta	Homo sapiens	27-36
1712069-7	1991	IL-1 beta bound to commercially purified "aged" alpha 2M and to alpha 2M in methylamine-treated serum but not to native serum alpha 2M.	methylamine	76-87	interleukin 1 beta	Homo sapiens	0-9
1999487-7	1991	Chymotrypsin cleaves 31-kD IL-1 beta at Tyr 113-Val 114, generating an 18-kD IL-1 species with activity equivalent to the authentic mature IL-1 beta (NH2-terminal Ala 117).	Alanine	163-166	interleukin 1 beta	Homo sapiens	27-36
1825941-4	1991	However, the interleukins IL-1 alpha, IL-1 beta, IL-2, and tumour necrosis factor (TNF) alpha and beta, but not IL-6, stimulated neopterin production by unfractionated peripheral blood mononuclear cells (PBMC), and culture supernatants from PBMC stimulated with IL-1 alpha, IL-1 beta, IL-2 and IL-6, but not TNF-alpha or TNF-beta induced neopterin production following transfer to fresh monocyte cultures.	Neopterin	129-138	interleukin 1 beta	Homo sapiens	38-47
1880018-8	1991	Third, the effect of 1,25-(OH)2D3 on PWM driven MNC was reversed by addition of the recombinant monokines: interleukin (IL)-1 beta, tumour necrosis factor alpha (rTNF alpha), rIL-6, as well as the lymphokines: lymphotoxin (rLT) and rIL-2.	Calcitriol	21-33	interleukin 1 beta	Homo sapiens	107-130
1871044-3	1991	The degradation and inactivation of IL-1 beta at or above 39 degrees C were attributed to autoxidation of the two cysteine residues in the denatured protein, followed by hydrophobic/covalent aggregation and precipitation.	Cysteine	114-122	interleukin 1 beta	Homo sapiens	36-45
2001363-1	1991	The determination of the high-resolution three-dimensional solution structure of interleukin 1 beta (IL-1 beta), a protein of 153 residues and 17.4 kDa, which plays a central role in the immune and inflammatory responses, has been determined by heteronuclear (13C and 15N) three- and four-dimensional NMR spectroscopy.	13c	260-263	interleukin 1 beta	Homo sapiens	81-99
2001363-1	1991	The determination of the high-resolution three-dimensional solution structure of interleukin 1 beta (IL-1 beta), a protein of 153 residues and 17.4 kDa, which plays a central role in the immune and inflammatory responses, has been determined by heteronuclear (13C and 15N) three- and four-dimensional NMR spectroscopy.	13c	260-263	interleukin 1 beta	Homo sapiens	101-110
2001363-1	1991	The determination of the high-resolution three-dimensional solution structure of interleukin 1 beta (IL-1 beta), a protein of 153 residues and 17.4 kDa, which plays a central role in the immune and inflammatory responses, has been determined by heteronuclear (13C and 15N) three- and four-dimensional NMR spectroscopy.	15n	268-271	interleukin 1 beta	Homo sapiens	81-99
2001363-1	1991	The determination of the high-resolution three-dimensional solution structure of interleukin 1 beta (IL-1 beta), a protein of 153 residues and 17.4 kDa, which plays a central role in the immune and inflammatory responses, has been determined by heteronuclear (13C and 15N) three- and four-dimensional NMR spectroscopy.	15n	268-271	interleukin 1 beta	Homo sapiens	101-110
1888884-2	1991	In addition, IL-1 beta dose-dependently stimulated the formation of prostaglandin E2 (PGE2) and 6-keto-PGF1 alpha in the calvarial bones.	Dinoprostone	68-84	interleukin 1 beta	Homo sapiens	13-22
1888884-2	1991	In addition, IL-1 beta dose-dependently stimulated the formation of prostaglandin E2 (PGE2) and 6-keto-PGF1 alpha in the calvarial bones.	Dinoprostone	86-90	interleukin 1 beta	Homo sapiens	13-22
1888884-2	1991	In addition, IL-1 beta dose-dependently stimulated the formation of prostaglandin E2 (PGE2) and 6-keto-PGF1 alpha in the calvarial bones.	6-Ketoprostaglandin F1 alpha	96-113	interleukin 1 beta	Homo sapiens	13-22
1888884-3	1991	However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta.	Dinoprostone	85-89	interleukin 1 beta	Homo sapiens	9-18
1888884-3	1991	However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta.	Indomethacin	104-116	interleukin 1 beta	Homo sapiens	9-18
1888884-3	1991	However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta.	Dinoprostone	143-147	interleukin 1 beta	Homo sapiens	173-182
1888884-3	1991	However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta.	Dinoprostone	143-147	interleukin 1 beta	Homo sapiens	173-182
1888884-3	1991	However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta.	Prostaglandins	245-259	interleukin 1 beta	Homo sapiens	9-18
1888884-3	1991	However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta.	Prostaglandins	245-259	interleukin 1 beta	Homo sapiens	173-182
1888884-3	1991	However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta.	Prostaglandins	245-259	interleukin 1 beta	Homo sapiens	173-182
1888884-7	1991	These data indicate that (1) IL-1 beta-induced stimulation of bone resorption is dissociable from IL-1 beta-induced increase of prostanoid biosynthesis and (2) the epitope of the IL-1 beta molecule involved in the immunostimulatory effects may be different from that involved in the stimulatory effects on bone resorption.	Prostaglandins	128-138	interleukin 1 beta	Homo sapiens	98-107
1888884-7	1991	These data indicate that (1) IL-1 beta-induced stimulation of bone resorption is dissociable from IL-1 beta-induced increase of prostanoid biosynthesis and (2) the epitope of the IL-1 beta molecule involved in the immunostimulatory effects may be different from that involved in the stimulatory effects on bone resorption.	Prostaglandins	128-138	interleukin 1 beta	Homo sapiens	98-107
1999487-7	1991	Chymotrypsin cleaves 31-kD IL-1 beta at Tyr 113-Val 114, generating an 18-kD IL-1 species with activity equivalent to the authentic mature IL-1 beta (NH2-terminal Ala 117).	Alanine	163-166	interleukin 1 beta	Homo sapiens	139-148
1999487-9	1991	Monocytes contain an IL-1 convertase enzyme that cleaves the IL-1 beta promolecule at Ala 117.	Alanine	86-89	interleukin 1 beta	Homo sapiens	21-25
1999487-9	1991	Monocytes contain an IL-1 convertase enzyme that cleaves the IL-1 beta promolecule at Ala 117.	Alanine	86-89	interleukin 1 beta	Homo sapiens	61-70
1857723-5	1991	In all experiments interleukin 1 beta consistently induced a stimulation of prostaglandin production that greatly exceeded that caused by any bacterial product.	Prostaglandins	76-89	interleukin 1 beta	Homo sapiens	19-37
2017372-6	1991	In contrast, when IL-1 was present in the medium, the level of gro mRNA was stable over 8 hours following addition of actinomycin D.	Dactinomycin	118-131	interleukin 1 beta	Homo sapiens	18-22
1900463-5	1991	The results make a role for endogenous prostaglandins and leukotrienes in the regulation of monocyte IL-1 beta and TNF-alpha production unlikely.	Prostaglandins	39-53	interleukin 1 beta	Homo sapiens	101-110
1900463-5	1991	The results make a role for endogenous prostaglandins and leukotrienes in the regulation of monocyte IL-1 beta and TNF-alpha production unlikely.	Leukotrienes	58-70	interleukin 1 beta	Homo sapiens	101-110
1997162-11	1991	Our results demonstrate that the glutamine antagonist acivicin modulates HL-60 cell expression of TNF-alpha, interleukin 1 beta, c-myc, and c-myb and suggest that interleukin 1 beta and TNF-alpha might (in an autocrine manner) cause the differentiation.	acivicin	54-62	interleukin 1 beta	Homo sapiens	109-127
1847874-1	1991	We examined the effect of tebufelone, a dual cyclooxygenase (CO)/5-lipoxygenase (LO) inhibitor, on the synthesis, secretion and gene expression of interleukin (IL) 1 beta and tumor necrosis factor (TNF)-alpha by human peripheral blood mononuclear cells (PBMC).	tebufelone	26-36	interleukin 1 beta	Homo sapiens	147-170
1997162-5	1991	Acivicin caused a decreased expression of c-myc, and an increased expression of mRNA for interleukin 1 beta and tumor necrosis factor alpha (TNF-alpha).	acivicin	0-8	interleukin 1 beta	Homo sapiens	89-107
1997162-7	1991	Supernatants and lysates of acivicin-treated HL-60 cells contained increased levels of interleukin 1 beta.	acivicin	28-36	interleukin 1 beta	Homo sapiens	87-105
1997162-11	1991	Our results demonstrate that the glutamine antagonist acivicin modulates HL-60 cell expression of TNF-alpha, interleukin 1 beta, c-myc, and c-myb and suggest that interleukin 1 beta and TNF-alpha might (in an autocrine manner) cause the differentiation.	Glutamine	33-42	interleukin 1 beta	Homo sapiens	109-127
1872919-0	1991	Inhibition of IL-1 beta expression in THP-1 cells by probucol and tocopherol.	Probucol	53-61	interleukin 1 beta	Homo sapiens	14-23
1872919-0	1991	Inhibition of IL-1 beta expression in THP-1 cells by probucol and tocopherol.	Tocopherols	66-76	interleukin 1 beta	Homo sapiens	14-23
1872919-2	1991	The possible action of probucol and tocopherol on the expression and secretion of IL-1 beta was investigated using the human monocytic leukemia cell line, THP-1.	Probucol	23-31	interleukin 1 beta	Homo sapiens	82-91
1872919-2	1991	The possible action of probucol and tocopherol on the expression and secretion of IL-1 beta was investigated using the human monocytic leukemia cell line, THP-1.	Tocopherols	36-46	interleukin 1 beta	Homo sapiens	82-91
1872919-3	1991	Both probucol and D-alpha-tocopherol inhibit the phorbol ester-induced release of IL-1 beta without altering differentiation.	Probucol	5-13	interleukin 1 beta	Homo sapiens	82-91
1872919-3	1991	Both probucol and D-alpha-tocopherol inhibit the phorbol ester-induced release of IL-1 beta without altering differentiation.	alpha-Tocopherol	18-36	interleukin 1 beta	Homo sapiens	82-91
1872919-3	1991	Both probucol and D-alpha-tocopherol inhibit the phorbol ester-induced release of IL-1 beta without altering differentiation.	Phorbol Esters	49-62	interleukin 1 beta	Homo sapiens	82-91
1872919-4	1991	Analysis of IL-1 beta mRNA levels revealed that probucol and tocopherol had an inhibitory effect on the activation of expression of the IL-1 beta gene.	Probucol	48-56	interleukin 1 beta	Homo sapiens	12-21
1872919-4	1991	Analysis of IL-1 beta mRNA levels revealed that probucol and tocopherol had an inhibitory effect on the activation of expression of the IL-1 beta gene.	Probucol	48-56	interleukin 1 beta	Homo sapiens	136-145
1872919-4	1991	Analysis of IL-1 beta mRNA levels revealed that probucol and tocopherol had an inhibitory effect on the activation of expression of the IL-1 beta gene.	Tocopherols	61-71	interleukin 1 beta	Homo sapiens	12-21
1872919-4	1991	Analysis of IL-1 beta mRNA levels revealed that probucol and tocopherol had an inhibitory effect on the activation of expression of the IL-1 beta gene.	Tocopherols	61-71	interleukin 1 beta	Homo sapiens	136-145
1847874-3	1991	By contrast, preincubation (1 h) of cells, in amounts of tebufelone which decrease the formation of leukotriene (LT) B4, markedly enhanced (up to 500%) the synthesis of IL 1 beta and TNF-alpha following lipopolysaccharide (LPS), heat-killed Staphylococcus epidermidis or concanavalin A stimulation.	tebufelone	57-67	interleukin 1 beta	Homo sapiens	169-178
1847874-8	1991	In conclusion, we have demonstrated that tebufelone enhances IL 1 (alpha and beta) and TNF-alpha synthesis at concentrations which suppress leukotriene formation.	tebufelone	41-51	interleukin 1 beta	Homo sapiens	61-65
2027111-2	1991	Piroxicam has been shown to downregulate the expression of interleukin 1 (IL-1) associated chondrocyte enzyme inducing activity (catabolin) produced by OA synovium.	Piroxicam	0-9	interleukin 1 beta	Homo sapiens	129-138
1945479-0	1991	Divergent effect of the anaerobic bacteria by-product butyric acid on the immune response: suppression of T-lymphocyte proliferation and stimulation of interleukin-1 beta production.	Butyric Acid	54-66	interleukin 1 beta	Homo sapiens	152-170
1645452-0	1991	The human myelomonocytic cell line U-937 as a model for studying alterations in steroid-induced monokine gene expression: marked enhancement of lipopolysaccharide-stimulated interleukin-1 beta messenger RNA levels by 1,25-dihydroxyvitamin D3.	Steroids	80-87	interleukin 1 beta	Homo sapiens	174-192
1645452-0	1991	The human myelomonocytic cell line U-937 as a model for studying alterations in steroid-induced monokine gene expression: marked enhancement of lipopolysaccharide-stimulated interleukin-1 beta messenger RNA levels by 1,25-dihydroxyvitamin D3.	Calcitriol	217-241	interleukin 1 beta	Homo sapiens	174-192
1645452-4	1991	Preincubation of cells with 1,25-(OH)2D3 augmented IL-1 beta mRNA levels only in U-937 and HL-60 cells.	Calcitriol	28-40	interleukin 1 beta	Homo sapiens	51-60
1945479-6	1991	Furthermore, butyric acid displayed an interesting biphasic stimulation of monocyte interleukin-1 beta production, a cytokine with a powerful bone-resorbing activity.	Butyric Acid	13-25	interleukin 1 beta	Homo sapiens	84-102
1988012-0	1991	Four-dimensional 13C/13C-edited nuclear Overhauser enhancement spectroscopy of a protein in solution: application to interleukin 1 beta.	13c	17-20	interleukin 1 beta	Homo sapiens	117-135
1994545-3	1991	Using Northern blot analysis, we examined the effect of 1,25(OH)2D3 pretreatment on IL-1 beta and TNF gene expression in LPS- and PHA-stimulated human PBMNC and several human myeloid cell lines (U937 and THP1).	Calcitriol	56-67	interleukin 1 beta	Homo sapiens	84-93
1999290-8	1991	A method based on acidification of the water-soluble protein fraction to pH 4.0 has been developed that allows for the isolation of 80%-pure re-hIL-1 beta.	Water	39-44	interleukin 1 beta	Homo sapiens	144-154
1988012-0	1991	Four-dimensional 13C/13C-edited nuclear Overhauser enhancement spectroscopy of a protein in solution: application to interleukin 1 beta.	13c	21-24	interleukin 1 beta	Homo sapiens	117-135
2050779-2	1991	The separation patterns for recombinant derived interleukin-1 beta (IL-1 beta) on the C4 column eluted with TFA-acetonitrile and the DVB column eluted with acetic acid-acetonitrile were similar, but only the polymeric column was able to separate the components present in an iodinated IL-1 beta preparation.	Trifluoroacetic Acid	108-111	interleukin 1 beta	Homo sapiens	48-66
2050779-2	1991	The separation patterns for recombinant derived interleukin-1 beta (IL-1 beta) on the C4 column eluted with TFA-acetonitrile and the DVB column eluted with acetic acid-acetonitrile were similar, but only the polymeric column was able to separate the components present in an iodinated IL-1 beta preparation.	acetonitrile	112-124	interleukin 1 beta	Homo sapiens	48-66
2050779-2	1991	The separation patterns for recombinant derived interleukin-1 beta (IL-1 beta) on the C4 column eluted with TFA-acetonitrile and the DVB column eluted with acetic acid-acetonitrile were similar, but only the polymeric column was able to separate the components present in an iodinated IL-1 beta preparation.	acetonitrile	112-124	interleukin 1 beta	Homo sapiens	68-77
1988012-2	1991	The experiment is demonstrated for uniformly (greater than 95%) 13C-labeled interleukin 1 beta, a protein of 153 residues and 17.4 kDa, which plays a key role in the immune response.	13c	64-67	interleukin 1 beta	Homo sapiens	76-94
1819211-2	1991	Interleukin-1-beta (IL-1-beta) was measured in the plasma and peripheral blood mononuclear cell lysates of uremic patients undergoing maintenance hemodialysis by means of either cuprophane or polysulfone membranes.	cuprammonium cellulose	178-188	interleukin 1 beta	Homo sapiens	0-18
2069091-0	1991	A novel inhibitor of IL-1 generation, E5090: in vitro inhibitory effects on the generation of IL-1 by human monocytes.	E 5090	38-43	interleukin 1 beta	Homo sapiens	21-25
2069091-0	1991	A novel inhibitor of IL-1 generation, E5090: in vitro inhibitory effects on the generation of IL-1 by human monocytes.	E 5090	38-43	interleukin 1 beta	Homo sapiens	94-98
2069091-1	1991	E5090 is an orally active inhibitor of IL-1 generation, being converted in vivo into the pharmacologically active deacetylated form (DA-E5090).	E 5090	0-5	interleukin 1 beta	Homo sapiens	39-43
1819211-2	1991	Interleukin-1-beta (IL-1-beta) was measured in the plasma and peripheral blood mononuclear cell lysates of uremic patients undergoing maintenance hemodialysis by means of either cuprophane or polysulfone membranes.	polysulfone P 1700	192-203	interleukin 1 beta	Homo sapiens	0-18
1819211-5	1991	The study of the kinetics of IL-1-beta concentration during a single hemodialysis session revealed that the concentration of IL-1-beta fell to 21 and 22% of the predialysis level with cuprophane and polysulfone, respectively.	cuprammonium cellulose	184-194	interleukin 1 beta	Homo sapiens	29-38
2069091-1	1991	E5090 is an orally active inhibitor of IL-1 generation, being converted in vivo into the pharmacologically active deacetylated form (DA-E5090).	DA-E 5090	133-141	interleukin 1 beta	Homo sapiens	39-43
2069091-2	1991	In vitro effects of DA-E5090 on the generation of IL-1 by human monocytes stimulated with LPS were examined.	DA-E 5090	20-28	interleukin 1 beta	Homo sapiens	50-54
1819211-5	1991	The study of the kinetics of IL-1-beta concentration during a single hemodialysis session revealed that the concentration of IL-1-beta fell to 21 and 22% of the predialysis level with cuprophane and polysulfone, respectively.	cuprammonium cellulose	184-194	interleukin 1 beta	Homo sapiens	125-134
2069091-3	1991	DA-E5090 inhibited both IL-1 alpha and IL-1 beta generation by human monocytes stimulated with 1 microgram/ml of LPS in a dose dependent-manner (1-10 microM), as determined by LAF assay and ELISA.	DA-E 5090	0-8	interleukin 1 beta	Homo sapiens	39-48
1819211-5	1991	The study of the kinetics of IL-1-beta concentration during a single hemodialysis session revealed that the concentration of IL-1-beta fell to 21 and 22% of the predialysis level with cuprophane and polysulfone, respectively.	polysulfone P 1700	199-210	interleukin 1 beta	Homo sapiens	29-38
2069091-4	1991	Northern blotting analysis indicated that DA-E5090 inhibits transcription of IL-1 alpha and IL-1 beta m-RNAs.	DA-E 5090	42-50	interleukin 1 beta	Homo sapiens	92-101
1819211-5	1991	The study of the kinetics of IL-1-beta concentration during a single hemodialysis session revealed that the concentration of IL-1-beta fell to 21 and 22% of the predialysis level with cuprophane and polysulfone, respectively.	polysulfone P 1700	199-210	interleukin 1 beta	Homo sapiens	125-134
1651782-2	1991	Since IL-1 alpha, IL-1 beta and TNF alpha have been previously demonstrated to play an important role in connective tissue destruction by stimulating the production of prostaglandin E2 (PGE2) and collagenase, these functions were investigated in the presence or absence of natural human IL-6 (nhIL-6) or recombinant human IL-6 (rhIL-6).	Dinoprostone	186-190	interleukin 1 beta	Homo sapiens	18-27
1902078-5	1991	Indomethacin enhanced IFN-gamma release and spontaneous and induced TNF-alpha secretion in all groups but stimulated IL-1 only in irradiated patients.	Indomethacin	0-12	interleukin 1 beta	Homo sapiens	117-121
1651782-2	1991	Since IL-1 alpha, IL-1 beta and TNF alpha have been previously demonstrated to play an important role in connective tissue destruction by stimulating the production of prostaglandin E2 (PGE2) and collagenase, these functions were investigated in the presence or absence of natural human IL-6 (nhIL-6) or recombinant human IL-6 (rhIL-6).	Dinoprostone	168-184	interleukin 1 beta	Homo sapiens	18-27
1824616-1	1991	Recombinant human interleukin-1 alpha (IL-1 alpha) and recombinant human IL-1 beta stimulate matrix proteoglycan degradation and inhibit glycosaminoglycan synthesis in bovine nasal cartilage explants.	Glycosaminoglycans	137-154	interleukin 1 beta	Homo sapiens	73-82
1934023-8	1991	Treatment of NRSC with human recombinant interleukin-1 beta (IL-1 beta) enhanced glucose uptake to a level similar to basal uptake by RSC.	Glucose	81-88	interleukin 1 beta	Homo sapiens	41-59
1934023-8	1991	Treatment of NRSC with human recombinant interleukin-1 beta (IL-1 beta) enhanced glucose uptake to a level similar to basal uptake by RSC.	Glucose	81-88	interleukin 1 beta	Homo sapiens	61-70
1934023-8	1991	Treatment of NRSC with human recombinant interleukin-1 beta (IL-1 beta) enhanced glucose uptake to a level similar to basal uptake by RSC.	rsc	14-17	interleukin 1 beta	Homo sapiens	41-59
1934023-8	1991	Treatment of NRSC with human recombinant interleukin-1 beta (IL-1 beta) enhanced glucose uptake to a level similar to basal uptake by RSC.	rsc	14-17	interleukin 1 beta	Homo sapiens	61-70
1934023-9	1991	These results suggest that autocrine production of IL-1 beta by RSC could be responsible for the higher basal glucose uptake by these cells.	rsc	64-67	interleukin 1 beta	Homo sapiens	51-60
1934023-9	1991	These results suggest that autocrine production of IL-1 beta by RSC could be responsible for the higher basal glucose uptake by these cells.	Glucose	110-117	interleukin 1 beta	Homo sapiens	51-60
1846109-5	1991	Human IL-1 beta and human IL-6 also showed a stimulatory effect on corticosterone production, whereas human IL-2 was inactive in this system.	Corticosterone	67-81	interleukin 1 beta	Homo sapiens	6-15
1873492-6	1991	However, in contrast to mouse or human MC the potency of IL-1 beta to induce PGE2 in Sprague Dawley rat MC was 26-fold higher compared to IL-1 alpha.	Dinoprostone	77-81	interleukin 1 beta	Homo sapiens	57-66
1904515-8	1991	Further investigations on the regulation of cytokine production and release by TPA-differentiated U937 cells revealed that TNF-alpha and IL-1 beta synthesis was not influenced by exogenously added rhTNF-alpha or PGE2, whereas rh gamma-IFN specifically enhanced the IL-1 beta production.	Tetradecanoylphorbol Acetate	79-82	interleukin 1 beta	Homo sapiens	137-146
1997401-2	1991	We examined the effects of 1,25-(OH)2D3 on the regulation of interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) genes in HL-60 and U937 cells.	Calcitriol	27-39	interleukin 1 beta	Homo sapiens	61-79
1997401-2	1991	We examined the effects of 1,25-(OH)2D3 on the regulation of interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) genes in HL-60 and U937 cells.	Calcitriol	27-39	interleukin 1 beta	Homo sapiens	81-90
2026474-2	1991	Anti-rheumatic drugs including Auranofin and Sulphasalazine suppressed IL-1 beta release significantly at therapeutic concentrations, whereas Bucillamine, Lobenzarit, D-Penicillamine and Ibuprofen did not.	Auranofin	31-40	interleukin 1 beta	Homo sapiens	71-80
2026474-2	1991	Anti-rheumatic drugs including Auranofin and Sulphasalazine suppressed IL-1 beta release significantly at therapeutic concentrations, whereas Bucillamine, Lobenzarit, D-Penicillamine and Ibuprofen did not.	Sulfasalazine	45-59	interleukin 1 beta	Homo sapiens	71-80
2026475-0	1991	Interleukin-1 beta release from human peripheral blood monocytes associated with phagocytosis of carbonyl-iron or erythrocytes.	Iron Carbonyl Compounds	97-110	interleukin 1 beta	Homo sapiens	0-18
2026475-1	1991	Interleukin-1 beta (IL-1 beta) release from human peripheral blood monocytes during the incubation with carbonyl-iron or sheep red blood cells was investigated.	Iron Carbonyl Compounds	104-117	interleukin 1 beta	Homo sapiens	0-18
2026475-1	1991	Interleukin-1 beta (IL-1 beta) release from human peripheral blood monocytes during the incubation with carbonyl-iron or sheep red blood cells was investigated.	Iron Carbonyl Compounds	104-117	interleukin 1 beta	Homo sapiens	20-29
1824588-6	1991	Metabolic inactivation of T cells using paraformaldehyde demonstrated that the ability of T cells to induce IL-1 mRNA via cell contact was acquired only after activation of T cells via solid phase anti-CD3.	paraform	40-56	interleukin 1 beta	Homo sapiens	108-112
1824588-9	1991	However, supernatants from purified T cells that were activated with solid-phase anti-CD3 restored the ability of paraformaldehyde or emetine-treated T cells to induce IL-1 secretion.	paraform	114-130	interleukin 1 beta	Homo sapiens	168-172
1824588-9	1991	However, supernatants from purified T cells that were activated with solid-phase anti-CD3 restored the ability of paraformaldehyde or emetine-treated T cells to induce IL-1 secretion.	Emetine	134-141	interleukin 1 beta	Homo sapiens	168-172
1846838-0	1991	5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease.	Mesalamine	0-21	interleukin 1 beta	Homo sapiens	47-65
1846838-3	1991	Values of interleukin 1 beta after culture correlated with concentrations of thromboxane B2.	Thromboxane B2	77-91	interleukin 1 beta	Homo sapiens	10-28
1846838-4	1991	Organ culture of inflamed biopsy specimens in the presence of 5 aminosalicylic acid and dexamethasone reduced the amount of interleukin 1 beta detected.	Aminosalicylic Acid	64-83	interleukin 1 beta	Homo sapiens	124-142
1846838-4	1991	Organ culture of inflamed biopsy specimens in the presence of 5 aminosalicylic acid and dexamethasone reduced the amount of interleukin 1 beta detected.	Dexamethasone	88-101	interleukin 1 beta	Homo sapiens	124-142
1847694-0	1991	Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells.	Nucleotides, Cyclic	0-18	interleukin 1 beta	Homo sapiens	93-111
1713637-6	1991	In contrast, IL-1 beta, TNF, and TPA equally stimulated increased levels of M-CSF, GM-CSF, IL-1 beta and IL-6 RNAs.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 beta	Homo sapiens	91-100
1775252-5	1991	The alternate use of Cuprophan and Hemophan demonstrated that the production of TNF and IL1 was dependent on the type of haemodialysis membrane.	Hemophan	35-43	interleukin 1 beta	Homo sapiens	88-91
1775252-6	1991	We also found that Cuprophan induced a reversible decrease of spontaneous and LPS-stimulated production of TNF, IL1 and IL6 during the haemodialysis session.	cuprammonium cellulose	19-28	interleukin 1 beta	Homo sapiens	112-115
1775252-3	1991	Circulating levels of TNF and unstimulated production of TNF and IL1 by monocytes were increased in patients dialysed with Hemophan, whereas a greater LPS-stimulated production of TNF was observed in patients dialysed with Cuprophan.	Hemophan	123-131	interleukin 1 beta	Homo sapiens	65-68
1775252-5	1991	The alternate use of Cuprophan and Hemophan demonstrated that the production of TNF and IL1 was dependent on the type of haemodialysis membrane.	cuprammonium cellulose	21-30	interleukin 1 beta	Homo sapiens	88-91
2017267-8	1991	The IL-1 beta levels rose with CU from 87 +/-18 (ng/l) to 155 +/- 33 at 60 min and to 172 +/- 47 at 240 min.	cuprammonium cellulose	31-33	interleukin 1 beta	Homo sapiens	4-13
1845137-0	1991	Products of oxidized linoleate mediate the release of interleukin-1 beta from human macrophages.	Linoleic Acid	21-30	interleukin 1 beta	Homo sapiens	54-72
1997611-9	1991	Moreover, the IL-1 alpha and IL-1 beta concentrations correlated with those of Prostaglandin E2 and F2 alpha in AF, measured by RIA.	Dinoprostone	79-95	interleukin 1 beta	Homo sapiens	29-38
2124235-4	1990	Human IL-1 beta (180 pM) and human rTNF-alpha (3 nM) significantly stimulated both CAT activity and PGE2 release.	Dinoprostone	100-104	interleukin 1 beta	Homo sapiens	6-15
2125218-4	1990	In addition, insulin response to intravenous glucose loading was also attenuated in ADX rats with pretreatment by IL-1.	Glucose	45-52	interleukin 1 beta	Homo sapiens	114-118
2125218-5	1990	At 4 hours after injection, ibuprofen (IBP; 0.5-50.0 mg/kg, ip), selective cyclooxygenase blocker, attenuated insulin inhibition by IL-1 in a dose-dependent manner.	Ibuprofen	28-37	interleukin 1 beta	Homo sapiens	132-136
2125218-5	1990	At 4 hours after injection, ibuprofen (IBP; 0.5-50.0 mg/kg, ip), selective cyclooxygenase blocker, attenuated insulin inhibition by IL-1 in a dose-dependent manner.	Ibuprofen	39-42	interleukin 1 beta	Homo sapiens	132-136
2125218-6	1990	These data suggest that IL-1 may suppress in vivo insulin release at least in part through the mediation of prostaglandin synthesis in the absence of adrenal glands.	Prostaglandins	108-121	interleukin 1 beta	Homo sapiens	24-28
2175610-3	1990	We found that in the presence of a constant amount of IL-1 beta, stimulation of hyaluronic acid (HA) synthesis by the IL-1 inhibitor was inhibited in a dose-dependent manner.	Hyaluronic Acid	80-95	interleukin 1 beta	Homo sapiens	54-63
2175610-3	1990	We found that in the presence of a constant amount of IL-1 beta, stimulation of hyaluronic acid (HA) synthesis by the IL-1 inhibitor was inhibited in a dose-dependent manner.	Hyaluronic Acid	97-99	interleukin 1 beta	Homo sapiens	54-63
2175219-0	1990	Control of interleukin-1 beta expression by protein kinase C and cyclic adenosine monophosphate in myeloid leukemia cells.	Cyclic AMP	65-95	interleukin 1 beta	Homo sapiens	11-29
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	94-119	interleukin 1 beta	Homo sapiens	174-183
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	94-119	interleukin 1 beta	Homo sapiens	220-229
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	121-124	interleukin 1 beta	Homo sapiens	174-183
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	121-124	interleukin 1 beta	Homo sapiens	220-229
2175219-4	1990	A structural analog of cyclic adenosine monophosphate (dbcAMP) or agents elevating the endogenous cAMP levels (prostaglandin E2, forskolin) were not alone able to induce IL-1 beta expression, but they strongly enhanced the PMA-induced IL-1 beta production and IL-1 beta mRNA accumulation.	Cyclic AMP	23-53	interleukin 1 beta	Homo sapiens	170-179
2175219-4	1990	A structural analog of cyclic adenosine monophosphate (dbcAMP) or agents elevating the endogenous cAMP levels (prostaglandin E2, forskolin) were not alone able to induce IL-1 beta expression, but they strongly enhanced the PMA-induced IL-1 beta production and IL-1 beta mRNA accumulation.	Cyclic AMP	23-53	interleukin 1 beta	Homo sapiens	235-244
2175219-4	1990	A structural analog of cyclic adenosine monophosphate (dbcAMP) or agents elevating the endogenous cAMP levels (prostaglandin E2, forskolin) were not alone able to induce IL-1 beta expression, but they strongly enhanced the PMA-induced IL-1 beta production and IL-1 beta mRNA accumulation.	Cyclic AMP	23-53	interleukin 1 beta	Homo sapiens	235-244
2175219-4	1990	A structural analog of cyclic adenosine monophosphate (dbcAMP) or agents elevating the endogenous cAMP levels (prostaglandin E2, forskolin) were not alone able to induce IL-1 beta expression, but they strongly enhanced the PMA-induced IL-1 beta production and IL-1 beta mRNA accumulation.	Bucladesine	55-61	interleukin 1 beta	Homo sapiens	235-244
2175219-4	1990	A structural analog of cyclic adenosine monophosphate (dbcAMP) or agents elevating the endogenous cAMP levels (prostaglandin E2, forskolin) were not alone able to induce IL-1 beta expression, but they strongly enhanced the PMA-induced IL-1 beta production and IL-1 beta mRNA accumulation.	Bucladesine	55-61	interleukin 1 beta	Homo sapiens	235-244
2175219-4	1990	A structural analog of cyclic adenosine monophosphate (dbcAMP) or agents elevating the endogenous cAMP levels (prostaglandin E2, forskolin) were not alone able to induce IL-1 beta expression, but they strongly enhanced the PMA-induced IL-1 beta production and IL-1 beta mRNA accumulation.	Dinoprostone	111-127	interleukin 1 beta	Homo sapiens	170-179
2175219-7	1990	PKC inhibitor, H7, also blocked effectively the PMA plus dbcAMP induced IL-1 beta production, while the protein kinase A (PKA) inhibitor, HA1004, had no effect, suggesting that PKA activation is not involved in the mechanism of action of cAMP in this case.	Tetradecanoylphorbol Acetate	48-51	interleukin 1 beta	Homo sapiens	72-81
2175219-7	1990	PKC inhibitor, H7, also blocked effectively the PMA plus dbcAMP induced IL-1 beta production, while the protein kinase A (PKA) inhibitor, HA1004, had no effect, suggesting that PKA activation is not involved in the mechanism of action of cAMP in this case.	Bucladesine	57-63	interleukin 1 beta	Homo sapiens	72-81
2175219-7	1990	PKC inhibitor, H7, also blocked effectively the PMA plus dbcAMP induced IL-1 beta production, while the protein kinase A (PKA) inhibitor, HA1004, had no effect, suggesting that PKA activation is not involved in the mechanism of action of cAMP in this case.	Cyclic AMP	59-63	interleukin 1 beta	Homo sapiens	72-81
2175219-8	1990	Collectively, the present findings show that cAMP-dependent signals can have a positive regulatory effect on the PKC-dependent activation of the IL-1 beta gene in cells derived from different stages of myeloid differentiation.	Cyclic AMP	45-49	interleukin 1 beta	Homo sapiens	145-154
2086453-0	1990	Metabolism and beta-cell function of rat pancreatic islets exposed to human interleukin-1 beta in the presence of a high glucose concentration.	Glucose	121-128	interleukin 1 beta	Homo sapiens	76-94
2086453-2	1990	Rat pancreatic islets exposed to human recombinant IL-1 beta (rIL-1 beta) for 48 h in vitro exhibit a markedly reduced glucose-stimulated insulin secretion.	Glucose	119-126	interleukin 1 beta	Homo sapiens	51-60
2086454-0	1990	Short-term exposure of rat pancreatic islets to human interleukin-1 beta increases cellular uptake of calcium.	Calcium	102-109	interleukin 1 beta	Homo sapiens	54-72
1707461-5	1990	At a concentration of 10(-5) M, dexamethasone partially suppressed the IL-1 enhanced expression of IL-6.	Dexamethasone	32-45	interleukin 1 beta	Homo sapiens	71-75
1965653-4	1990	Cs also significantly inhibited IL-1 beta and TNF alpha production.	Cyclosporine	0-2	interleukin 1 beta	Homo sapiens	32-41
1700994-2	1990	The characteristics of the H alpha 2M IL-1 beta complex formation suggested, that cleavage of the internal thiol ester in other members of the alpha-macroglobulin family (alpha M) could enable these proteins to bind IL-1 beta.	thiol ester	107-118	interleukin 1 beta	Homo sapiens	38-47
1700994-2	1990	The characteristics of the H alpha 2M IL-1 beta complex formation suggested, that cleavage of the internal thiol ester in other members of the alpha-macroglobulin family (alpha M) could enable these proteins to bind IL-1 beta.	thiol ester	107-118	interleukin 1 beta	Homo sapiens	216-225
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Metals	201-206	interleukin 1 beta	Homo sapiens	56-65
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Metals	201-206	interleukin 1 beta	Homo sapiens	103-112
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Zinc	222-226	interleukin 1 beta	Homo sapiens	56-65
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Zinc	222-226	interleukin 1 beta	Homo sapiens	103-112
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	cupric ion	234-238	interleukin 1 beta	Homo sapiens	56-65
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	cupric ion	234-238	interleukin 1 beta	Homo sapiens	103-112
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Nickel(2+)	240-244	interleukin 1 beta	Homo sapiens	56-65
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Nickel(2+)	240-244	interleukin 1 beta	Homo sapiens	103-112
1700994-5	1990	Time kinetic studies showed that binding of IL-1 beta to H alpha 2M was complete within 200 min and that H alpha 2M-IL-1 beta complexes became increasingly resistant to dissociation by boiling in SDS as a function of incubation time.	Sodium Dodecyl Sulfate	196-199	interleukin 1 beta	Homo sapiens	116-125
1700994-7	1990	In each instance, alpha M-IL-1 beta complex formation was observed only after treatment of alpha M with methylamine, a primary amine that causes cleavage of the internal thiol ester in alpha M and the appearance of free thiol groups.	methylamine	104-115	interleukin 1 beta	Homo sapiens	26-35
1700994-7	1990	In each instance, alpha M-IL-1 beta complex formation was observed only after treatment of alpha M with methylamine, a primary amine that causes cleavage of the internal thiol ester in alpha M and the appearance of free thiol groups.	Amines	110-115	interleukin 1 beta	Homo sapiens	26-35
1700994-7	1990	In each instance, alpha M-IL-1 beta complex formation was observed only after treatment of alpha M with methylamine, a primary amine that causes cleavage of the internal thiol ester in alpha M and the appearance of free thiol groups.	thiol ester	170-181	interleukin 1 beta	Homo sapiens	26-35
1700994-7	1990	In each instance, alpha M-IL-1 beta complex formation was observed only after treatment of alpha M with methylamine, a primary amine that causes cleavage of the internal thiol ester in alpha M and the appearance of free thiol groups.	Sulfhydryl Compounds	170-175	interleukin 1 beta	Homo sapiens	26-35
2121579-10	1990	These results show that IC interleukin-1 beta acts centrally to induce a long-lasting inhibition of gastric acid secretion, and this effect requires the integrity of prostaglandin pathways.	Prostaglandins	166-179	interleukin 1 beta	Homo sapiens	27-45
2125363-6	1990	Both IL-1 alpha and IL-1 beta induced production of IL-6 mRNA and of PGE2 in these cell types.	Dinoprostone	69-73	interleukin 1 beta	Homo sapiens	20-29
2125363-8	1990	Dexamethasone did not inhibit HLA-DR expression in the cells studied but eliminated the inhibitory effect of IL-1 on such expression.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	109-113
2128336-19	1990	injection of IL-1 significantly decreased the plasma concentration of iron and zinc and increased the plasma fibrinogen concentration and the circulating leucocyte count in both the control and the trained groups.	Iron	70-74	interleukin 1 beta	Homo sapiens	13-17
1700730-2	1990	We demonstrate that both IL-1 alpha and IL-1 beta treatment of these cells led to stimulation of DNA synthesis (as shown by increase of 3H-thymidine incorporation up to 35-fold) and also resulted in colony formation of leukemic megakaryoblasts.	3h-thymidine	136-148	interleukin 1 beta	Homo sapiens	40-49
2145179-2	1990	One mutein, clone 18, which substitutes a threonine and methionine for the alanine and proline at positions 1 and 2 of the N-terminus of fully processed and active IL-1 beta, demonstrated similar activity to that of native IL-1 beta in inducing granulocyte-macrophage colony-stimulating activity (GM-CSA) from cultured fibroblasts.	Proline	87-94	interleukin 1 beta	Homo sapiens	164-173
2145179-2	1990	One mutein, clone 18, which substitutes a threonine and methionine for the alanine and proline at positions 1 and 2 of the N-terminus of fully processed and active IL-1 beta, demonstrated similar activity to that of native IL-1 beta in inducing granulocyte-macrophage colony-stimulating activity (GM-CSA) from cultured fibroblasts.	gm-csa	297-303	interleukin 1 beta	Homo sapiens	223-232
2145179-4	1990	The second mutein was GLU-4, which in addition to substituting alanine and proline by threonine and methionine also substituted glutamine for arginine at position 4 of the processed IL-1 beta molecule.	Glutamic Acid	22-25	interleukin 1 beta	Homo sapiens	182-191
2145179-5	1990	GLU-4 required a 3-log increase in concentration to obtain the same GM-CSA release from fibroblasts and to produce the same amount of competitive binding inhibition as clone 18 and native IL-1 beta.	Glutamic Acid	0-3	interleukin 1 beta	Homo sapiens	188-197
2145179-6	1990	In addition, preincubation of bone marrow cells with clone 18 and native IL-1 beta demonstrated a greater ability to protect early hematopoietic progenitors from the lethal effects of 4-hydroperoxycyclophosphamide when compared to similar concentrations of GLU-4.	perfosfamide	184-213	interleukin 1 beta	Homo sapiens	73-82
2145179-6	1990	In addition, preincubation of bone marrow cells with clone 18 and native IL-1 beta demonstrated a greater ability to protect early hematopoietic progenitors from the lethal effects of 4-hydroperoxycyclophosphamide when compared to similar concentrations of GLU-4.	Glutamic Acid	257-260	interleukin 1 beta	Homo sapiens	73-82
2145179-7	1990	A greater number of large granulocyte-macrophage, erythroid, and mixed colonies as well as blast cell colonies were observed when bone marrow cells were preincubated for 20 h with clone 18 or native IL-1 beta as compared to preincubation with GLU-4 or medium alone.	Glutamic Acid	243-246	interleukin 1 beta	Homo sapiens	199-208
2145179-8	1990	Therefore, arginine at position 4 of the processed IL-1 beta molecule was shown to be a key residue in the function of IL-1 beta as a hematopoietic regulator.	Arginine	11-19	interleukin 1 beta	Homo sapiens	51-60
2145179-8	1990	Therefore, arginine at position 4 of the processed IL-1 beta molecule was shown to be a key residue in the function of IL-1 beta as a hematopoietic regulator.	Arginine	11-19	interleukin 1 beta	Homo sapiens	119-128
2150740-8	1990	Treatment of synoviocytes for eight days with the same concentrations of Etodolac did not modify their collagen production but suppressed totally the inhibitory effect of IL-1.	Etodolac	73-81	interleukin 1 beta	Homo sapiens	171-175
2104237-7	1990	IL 1 concentration was high in spontaneous (IL 1 alpha, 3.7; IL 1 beta, 0.3 ng/mL) and pilocarpine induced sweat (IL 1 alpha, 3.9; IL 1 beta, 1.2 ng/mL), and it was much increased during jogging and sauna (IL 1 alpha, 22.6; IL 1 beta, 3.3 ng/mL).	Pilocarpine	87-98	interleukin 1 beta	Homo sapiens	131-140
2104237-7	1990	IL 1 concentration was high in spontaneous (IL 1 alpha, 3.7; IL 1 beta, 0.3 ng/mL) and pilocarpine induced sweat (IL 1 alpha, 3.9; IL 1 beta, 1.2 ng/mL), and it was much increased during jogging and sauna (IL 1 alpha, 22.6; IL 1 beta, 3.3 ng/mL).	Pilocarpine	87-98	interleukin 1 beta	Homo sapiens	131-140
2172027-4	1990	Furthermore, the guanylate cyclase inhibitor Methylene blue completely blocked IL-1 beta- and TNF alpha-stimulated cGMP generation.	Cyclic GMP	115-119	interleukin 1 beta	Homo sapiens	79-88
1699802-2	1990	The covalently cross-linked binding protein/[125I]IL-1 beta migrated at 60 kDa by SDS-PAGE.	Sodium Dodecyl Sulfate	82-85	interleukin 1 beta	Homo sapiens	50-59
2172027-5	1990	NG-mono-methyl-L-arginine attenuated IL-1 beta- and TNF alpha-induced cGMP production, an effect that was reversed by L-arginine.	omega-N-Methylarginine	0-25	interleukin 1 beta	Homo sapiens	37-46
2172027-1	1990	Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) or recombinant human tumor necrosis factor alpha (TNF alpha) dose-dependently increased cGMP formation.	Cyclic GMP	171-175	interleukin 1 beta	Homo sapiens	52-70
2172027-1	1990	Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) or recombinant human tumor necrosis factor alpha (TNF alpha) dose-dependently increased cGMP formation.	Cyclic GMP	171-175	interleukin 1 beta	Homo sapiens	72-81
2172027-5	1990	NG-mono-methyl-L-arginine attenuated IL-1 beta- and TNF alpha-induced cGMP production, an effect that was reversed by L-arginine.	Cyclic GMP	70-74	interleukin 1 beta	Homo sapiens	37-46
2172027-2	1990	Both IL-1 beta and TNF alpha-stimulated formation of cGMP occurred after a initial lag period of 4 to 8 hours.	Cyclic GMP	53-57	interleukin 1 beta	Homo sapiens	5-14
2172027-5	1990	NG-mono-methyl-L-arginine attenuated IL-1 beta- and TNF alpha-induced cGMP production, an effect that was reversed by L-arginine.	Arginine	15-25	interleukin 1 beta	Homo sapiens	37-46
2172027-4	1990	Furthermore, the guanylate cyclase inhibitor Methylene blue completely blocked IL-1 beta- and TNF alpha-stimulated cGMP generation.	Methylene Blue	45-59	interleukin 1 beta	Homo sapiens	79-88
2171341-3	1990	The intracellular concentration of both cyclic adenosine monophosphate and cyclic guanosine monophosphate increased in the presence of interleukin-1 beta.	Cyclic AMP	40-70	interleukin 1 beta	Homo sapiens	135-153
1700570-4	1990	At 3.3 mmol/l of glucose, 60,000 U/l of interleukin 1 beta caused an inhibition of medium insulin accumulation to 62 +/- 5% of control from 48 h to 6 days of exposure, whereas islet DNA content was unaffected.	Glucose	17-24	interleukin 1 beta	Homo sapiens	40-58
1700570-5	1990	At 11 mmol/l of glucose, interleukin 1 beta dose-dependently decreased medium insulin accumulation (e.g. 60,000 U/l of interleukin 1 beta, 12 +/- 3% of control) and islet content of DNA (60,000 U/l of interleukin 1 beta, 60 +/- 8% of control).	Glucose	16-23	interleukin 1 beta	Homo sapiens	25-43
1700570-5	1990	At 11 mmol/l of glucose, interleukin 1 beta dose-dependently decreased medium insulin accumulation (e.g. 60,000 U/l of interleukin 1 beta, 12 +/- 3% of control) and islet content of DNA (60,000 U/l of interleukin 1 beta, 60 +/- 8% of control).	Glucose	16-23	interleukin 1 beta	Homo sapiens	119-137
1700570-5	1990	At 11 mmol/l of glucose, interleukin 1 beta dose-dependently decreased medium insulin accumulation (e.g. 60,000 U/l of interleukin 1 beta, 12 +/- 3% of control) and islet content of DNA (60,000 U/l of interleukin 1 beta, 60 +/- 8% of control).	Glucose	16-23	interleukin 1 beta	Homo sapiens	119-137
1700570-6	1990	During beta-cell stimulation with tolbutamide, interleukin 1 beta caused inhibition of insulin accumulation to 36 +/- 9% of control.	Tolbutamide	34-45	interleukin 1 beta	Homo sapiens	47-65
1700570-7	1990	In contrast, on islets stimulated with iso-butyl 1-methyl-xanthine or glucagon, the effects of interleukin 1 beta were equivalent to those on non-stimulated islets.	iso-butyl 1-methyl-xanthine	39-66	interleukin 1 beta	Homo sapiens	95-113
1700570-7	1990	In contrast, on islets stimulated with iso-butyl 1-methyl-xanthine or glucagon, the effects of interleukin 1 beta were equivalent to those on non-stimulated islets.	Glucagon	70-78	interleukin 1 beta	Homo sapiens	95-113
2171341-3	1990	The intracellular concentration of both cyclic adenosine monophosphate and cyclic guanosine monophosphate increased in the presence of interleukin-1 beta.	Cyclic GMP	75-105	interleukin 1 beta	Homo sapiens	135-153
2171341-4	1990	The addition of indomethacin, a prostaglandin synthesis inhibitor, partially reversed the effect of interleukin-1 beta.	Indomethacin	16-28	interleukin 1 beta	Homo sapiens	100-118
2171341-4	1990	The addition of indomethacin, a prostaglandin synthesis inhibitor, partially reversed the effect of interleukin-1 beta.	Prostaglandins	32-45	interleukin 1 beta	Homo sapiens	100-118
2171341-5	1990	The same doses of interleukin-1 beta stimulated the release of adrenocorticotropin hormone and this effect was partially reversed by the addition of a synthetic corticotropin-releasing factor antagonist or by indomethacin.	Indomethacin	209-221	interleukin 1 beta	Homo sapiens	18-36
2288648-0	1990	Danazol suppresses the production of interleukin-1 beta and tumor necrosis factor by human monocytes.	Danazol	0-7	interleukin 1 beta	Homo sapiens	37-55
2118930-5	1990	Monocytes preincubated for 1 day in 1,25-(OH)2-D3 alone or in both IFN-gamma and 1,25-(OH)2-D3 exhibited similar kinetics and peak expression of LPS-induced IL-1 beta mRNA levels as cells cultured in medium.	Calcitriol	36-49	interleukin 1 beta	Homo sapiens	157-166
2288648-1	1990	The effects of estradiol (E2), progesterone (P), and danazol on the production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF) by OK-432 (a streptococcal preparation)-stimulated monocytes were examined.	Danazol	53-60	interleukin 1 beta	Homo sapiens	82-100
2288648-1	1990	The effects of estradiol (E2), progesterone (P), and danazol on the production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF) by OK-432 (a streptococcal preparation)-stimulated monocytes were examined.	Danazol	53-60	interleukin 1 beta	Homo sapiens	102-111
2288648-4	1990	Danazol inhibited IL-1 beta and TNF production by monocytes in a dose-dependent manner from not only donors with lower control levels of IL-1 beta and TNF but also donors with higher control levels of IL-1 beta and TNF.	Danazol	0-7	interleukin 1 beta	Homo sapiens	18-27
2288648-4	1990	Danazol inhibited IL-1 beta and TNF production by monocytes in a dose-dependent manner from not only donors with lower control levels of IL-1 beta and TNF but also donors with higher control levels of IL-1 beta and TNF.	Danazol	0-7	interleukin 1 beta	Homo sapiens	137-146
2288648-4	1990	Danazol inhibited IL-1 beta and TNF production by monocytes in a dose-dependent manner from not only donors with lower control levels of IL-1 beta and TNF but also donors with higher control levels of IL-1 beta and TNF.	Danazol	0-7	interleukin 1 beta	Homo sapiens	137-146
2288648-5	1990	Danazol at a concentration of 10(-6) M significantly suppressed IL-1 beta and TNF production in the presence of E2 and/or P at concentrations giving peak responses of IL-1 beta production.	Danazol	0-7	interleukin 1 beta	Homo sapiens	64-73
2288648-5	1990	Danazol at a concentration of 10(-6) M significantly suppressed IL-1 beta and TNF production in the presence of E2 and/or P at concentrations giving peak responses of IL-1 beta production.	Danazol	0-7	interleukin 1 beta	Homo sapiens	167-176
2172157-2	1990	The generation of superoxide by Epstein-Barr virus (EBV)-transformed human B lymphocytes can be stimulated by a range of compounds; receptor-dependent stimuli include tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and lipopolysaccharides (LPS), and independent stimuli include AlF3, A21387 and ionomycin.	Superoxides	18-28	interleukin 1 beta	Homo sapiens	209-227
2172157-2	1990	The generation of superoxide by Epstein-Barr virus (EBV)-transformed human B lymphocytes can be stimulated by a range of compounds; receptor-dependent stimuli include tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and lipopolysaccharides (LPS), and independent stimuli include AlF3, A21387 and ionomycin.	Superoxides	18-28	interleukin 1 beta	Homo sapiens	229-238
2394035-4	1990	Zymosan stimulated monocytes to produce IL-1 but not IL-1 inhibitor.	Zymosan	0-7	interleukin 1 beta	Homo sapiens	40-44
1698820-3	1990	After exposure to LPS (10 micrograms/ml) and 12-O-tetradecanoylphorbol-13-acetate (TPA, 100 nM) for 12 h, these HIV-1-infected monoblasts accumulated 8-15-fold greater levels of IL-1 beta RNA as compared with their HIV-1-uninfected counterparts that were similarly stimulated.	Tetradecanoylphorbol Acetate	45-81	interleukin 1 beta	Homo sapiens	178-187
1698820-3	1990	After exposure to LPS (10 micrograms/ml) and 12-O-tetradecanoylphorbol-13-acetate (TPA, 100 nM) for 12 h, these HIV-1-infected monoblasts accumulated 8-15-fold greater levels of IL-1 beta RNA as compared with their HIV-1-uninfected counterparts that were similarly stimulated.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 beta	Homo sapiens	178-187
1698820-6	1990	Time-course experiments showed that the maximal levels of IL-1 beta RNA occurred at 12 and 24 h after LPS and TPA stimulation of the HIV-1-infected and uninfected U937 cells, respectively.	Tetradecanoylphorbol Acetate	110-113	interleukin 1 beta	Homo sapiens	58-67
1698820-7	1990	Studies of stability of RNA using actinomycin D showed that IL-1 beta RNA was equally stable in infected and uninfected U937 cells after their stimulation with TPA and LPS.	Dactinomycin	34-47	interleukin 1 beta	Homo sapiens	60-69
1698820-7	1990	Studies of stability of RNA using actinomycin D showed that IL-1 beta RNA was equally stable in infected and uninfected U937 cells after their stimulation with TPA and LPS.	Tetradecanoylphorbol Acetate	160-163	interleukin 1 beta	Homo sapiens	60-69
2118930-5	1990	Monocytes preincubated for 1 day in 1,25-(OH)2-D3 alone or in both IFN-gamma and 1,25-(OH)2-D3 exhibited similar kinetics and peak expression of LPS-induced IL-1 beta mRNA levels as cells cultured in medium.	Calcitriol	81-94	interleukin 1 beta	Homo sapiens	157-166
2169012-11	1990	In addition, TN-55 may also work as an IL-1 antagonist to block PGE2 production induced by IL-1 through receptor competition.	tn-55	13-18	interleukin 1 beta	Homo sapiens	91-95
2169012-0	1990	A human IL-1 alpha derivative which lacks prostaglandin E2 inducing activity and inhibits the activity of IL-1 through receptor competition.	Dinoprostone	42-58	interleukin 1 beta	Homo sapiens	8-12
2121675-7	1990	This antiproliferative effect of IL-1 beta in combination with nHuTNF-alpha was reduced by the intravenous administration of anti-asialo GM1 antibody and carrageenan.	G(M1) Ganglioside	137-140	interleukin 1 beta	Homo sapiens	33-42
2121675-7	1990	This antiproliferative effect of IL-1 beta in combination with nHuTNF-alpha was reduced by the intravenous administration of anti-asialo GM1 antibody and carrageenan.	Carrageenan	154-165	interleukin 1 beta	Homo sapiens	33-42
2169012-11	1990	In addition, TN-55 may also work as an IL-1 antagonist to block PGE2 production induced by IL-1 through receptor competition.	tn-55	13-18	interleukin 1 beta	Homo sapiens	39-43
2169012-11	1990	In addition, TN-55 may also work as an IL-1 antagonist to block PGE2 production induced by IL-1 through receptor competition.	Dinoprostone	64-68	interleukin 1 beta	Homo sapiens	39-43
2121675-9	1990	It was suggested that asialo GM1-positive cells and macrophage were two of the most important effectors of the antiproliferative effect of IL-1 beta and TNF-alpha.	G(M1) Ganglioside	29-32	interleukin 1 beta	Homo sapiens	139-148
2169012-11	1990	In addition, TN-55 may also work as an IL-1 antagonist to block PGE2 production induced by IL-1 through receptor competition.	Dinoprostone	64-68	interleukin 1 beta	Homo sapiens	91-95
2098699-6	1990	The LPS of A. actinomycetemcomitans stimulated increased levels of IL-1 beta mRNA in the presence of cycloheximide, showing that stimulation by this LPS did not require new synthesis of protein.	Cycloheximide	101-114	interleukin 1 beta	Homo sapiens	67-76
2098699-7	1990	Furthermore, dexamethasone inhibited the ability of LPS from A. actinomycetemcomitans to stimulate the accumulation of mRNA coding for IL-1 beta.	Dexamethasone	13-26	interleukin 1 beta	Homo sapiens	135-144
2206968-4	1990	Immunoblot patterns of epidermal extracts revealed both the mature form of IL-1 (17 kDa) and the precursor (36 kDa) and were identical in amounts whether the specimens were from controls or from RA- or corticosteroid-treated skin.	Tretinoin	195-197	interleukin 1 beta	Homo sapiens	75-79
2261471-0	1990	Assignment of the side-chain 1H and 13C resonances of interleukin-1 beta using double- and triple-resonance heteronuclear three-dimensional NMR spectroscopy.	Hydrogen	29-31	interleukin 1 beta	Homo sapiens	54-72
2261471-0	1990	Assignment of the side-chain 1H and 13C resonances of interleukin-1 beta using double- and triple-resonance heteronuclear three-dimensional NMR spectroscopy.	13c	36-39	interleukin 1 beta	Homo sapiens	54-72
2261471-1	1990	The assignment of the aliphatic 1H and 13C resonances of IL-1 beta, a protein of 153 residues and molecular mass 17.4 kDa, is presented by use of a number of novel three-dimensional (3D) heteronuclear NMR experiments which rely on large heteronuclear one-bond J couplings to transfer magnetization and establish through-bond connectivities.	Hydrogen	32-34	interleukin 1 beta	Homo sapiens	57-66
2261471-1	1990	The assignment of the aliphatic 1H and 13C resonances of IL-1 beta, a protein of 153 residues and molecular mass 17.4 kDa, is presented by use of a number of novel three-dimensional (3D) heteronuclear NMR experiments which rely on large heteronuclear one-bond J couplings to transfer magnetization and establish through-bond connectivities.	13c	39-42	interleukin 1 beta	Homo sapiens	57-66
2202741-0	1990	Human recombinant interleukin-1 beta- and tumor necrosis factor alpha-mediated suppression of heparin-like compounds on cultured porcine aortic endothelial cells.	Heparin	94-101	interleukin 1 beta	Homo sapiens	18-69
2167234-2	1990	The protein kinase C inhibitor H-7 was shown to inhibit both IL-1 beta- and TNF alpha-induced granulocyte-macrophage colony-stimulating activity (GM-CSA) production and release from cultured fibroblasts in a dose-dependent manner, with 40 microM H-7 demonstrating maximum suppression of the GM-CSA response.	gm-csa	291-297	interleukin 1 beta	Homo sapiens	61-70
2167234-3	1990	In addition, 100-200 nM staurosporine, a more potent inhibitor of protein kinase C, also completely suppressed GM-CSA from IL-1 beta- and TNF alpha-induced fibroblasts.	Staurosporine	24-37	interleukin 1 beta	Homo sapiens	123-132
2167234-3	1990	In addition, 100-200 nM staurosporine, a more potent inhibitor of protein kinase C, also completely suppressed GM-CSA from IL-1 beta- and TNF alpha-induced fibroblasts.	gm-csa	111-117	interleukin 1 beta	Homo sapiens	123-132
2167234-8	1990	Furthermore, the addition of H-7 30 min after induction with IL-1 beta or TNF alpha showed little effect on the synthesis of GM-CSA by cultured fibroblasts, indicating that the signal transduction process probably occurred within the first 30 min of ligand-receptor interaction.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	29-32	interleukin 1 beta	Homo sapiens	61-70
2167234-9	1990	Finally, amelioride, an inhibitor of the Na(+)-H+ antiport, was shown to inhibit IL-1 beta-induced GM-CSA in a dose-dependent manner.	amelioride	9-19	interleukin 1 beta	Homo sapiens	81-90
2167234-9	1990	Finally, amelioride, an inhibitor of the Na(+)-H+ antiport, was shown to inhibit IL-1 beta-induced GM-CSA in a dose-dependent manner.	sodium bisulfide	41-49	interleukin 1 beta	Homo sapiens	81-90
2167234-9	1990	Finally, amelioride, an inhibitor of the Na(+)-H+ antiport, was shown to inhibit IL-1 beta-induced GM-CSA in a dose-dependent manner.	gm-csa	99-105	interleukin 1 beta	Homo sapiens	81-90
2167217-0	1990	Interleukin-1 beta modulates thyrotropin-induced thyroglobulin mRNA transcription through 3",5"-cyclic adenosine monophosphate.	3",5"-cyclic adenosine monophosphate	90-126	interleukin 1 beta	Homo sapiens	0-18
2167217-6	1990	IL-1 beta had no effect on basal TG release but modulates the TSH-stimulated TG secretion.	Thyrotropin	62-65	interleukin 1 beta	Homo sapiens	0-9
2167217-7	1990	At low dose (10(-5) to 10(-3) U/ml) IL-1 beta increased the TSH-stimulated TG secretion while higher doses (1-100 U/ml) of IL-1 beta had an inhibitory effect.	Thyrotropin	60-63	interleukin 1 beta	Homo sapiens	36-45
2167217-7	1990	At low dose (10(-5) to 10(-3) U/ml) IL-1 beta increased the TSH-stimulated TG secretion while higher doses (1-100 U/ml) of IL-1 beta had an inhibitory effect.	Thyrotropin	60-63	interleukin 1 beta	Homo sapiens	123-132
2167217-11	1990	This biphasic effect of IL-1 beta on TG synthesis is paralleled by a similar change in TSH-stimulated cAMP secretion.	Thyrotropin	87-90	interleukin 1 beta	Homo sapiens	24-33
2167217-11	1990	This biphasic effect of IL-1 beta on TG synthesis is paralleled by a similar change in TSH-stimulated cAMP secretion.	Cyclic AMP	102-106	interleukin 1 beta	Homo sapiens	24-33
2167217-12	1990	We conclude that IL-1 beta possesses hormonal action on TG gene transcription and its effect is mediated via cAMP.	Cyclic AMP	109-113	interleukin 1 beta	Homo sapiens	17-26
2167234-2	1990	The protein kinase C inhibitor H-7 was shown to inhibit both IL-1 beta- and TNF alpha-induced granulocyte-macrophage colony-stimulating activity (GM-CSA) production and release from cultured fibroblasts in a dose-dependent manner, with 40 microM H-7 demonstrating maximum suppression of the GM-CSA response.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	31-34	interleukin 1 beta	Homo sapiens	61-70
2167234-2	1990	The protein kinase C inhibitor H-7 was shown to inhibit both IL-1 beta- and TNF alpha-induced granulocyte-macrophage colony-stimulating activity (GM-CSA) production and release from cultured fibroblasts in a dose-dependent manner, with 40 microM H-7 demonstrating maximum suppression of the GM-CSA response.	gm-csa	146-152	interleukin 1 beta	Homo sapiens	61-70
2167234-2	1990	The protein kinase C inhibitor H-7 was shown to inhibit both IL-1 beta- and TNF alpha-induced granulocyte-macrophage colony-stimulating activity (GM-CSA) production and release from cultured fibroblasts in a dose-dependent manner, with 40 microM H-7 demonstrating maximum suppression of the GM-CSA response.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	246-249	interleukin 1 beta	Homo sapiens	61-70
2202741-3	1990	Incorporation of [35S]sulfate into heparan sulfate on cultured porcine aortic endothelial cells was suppressed by human recombinant interleukin-1 beta (rIL-1 beta) or tumor necrosis factor alpha (rTNF alpha) in a dose- and time-dependent manner with little effect on cell number, protein content, and [3H]leucine incorporation of cells.	Sulfur-35	18-21	interleukin 1 beta	Homo sapiens	132-150
2202741-3	1990	Incorporation of [35S]sulfate into heparan sulfate on cultured porcine aortic endothelial cells was suppressed by human recombinant interleukin-1 beta (rIL-1 beta) or tumor necrosis factor alpha (rTNF alpha) in a dose- and time-dependent manner with little effect on cell number, protein content, and [3H]leucine incorporation of cells.	Sulfates	22-29	interleukin 1 beta	Homo sapiens	132-150
2202741-3	1990	Incorporation of [35S]sulfate into heparan sulfate on cultured porcine aortic endothelial cells was suppressed by human recombinant interleukin-1 beta (rIL-1 beta) or tumor necrosis factor alpha (rTNF alpha) in a dose- and time-dependent manner with little effect on cell number, protein content, and [3H]leucine incorporation of cells.	Heparitin Sulfate	35-50	interleukin 1 beta	Homo sapiens	132-150
2202741-3	1990	Incorporation of [35S]sulfate into heparan sulfate on cultured porcine aortic endothelial cells was suppressed by human recombinant interleukin-1 beta (rIL-1 beta) or tumor necrosis factor alpha (rTNF alpha) in a dose- and time-dependent manner with little effect on cell number, protein content, and [3H]leucine incorporation of cells.	Tritium	302-304	interleukin 1 beta	Homo sapiens	132-150
2202741-3	1990	Incorporation of [35S]sulfate into heparan sulfate on cultured porcine aortic endothelial cells was suppressed by human recombinant interleukin-1 beta (rIL-1 beta) or tumor necrosis factor alpha (rTNF alpha) in a dose- and time-dependent manner with little effect on cell number, protein content, and [3H]leucine incorporation of cells.	Leucine	305-312	interleukin 1 beta	Homo sapiens	132-150
2290154-2	1990	Highly purified interleukin 1 (IL-1) (17 kDa) and recombinant IL-1 beta in the concentration range 0.2-20 U/ml released significant amounts of calcium.	Calcium	143-150	interleukin 1 beta	Homo sapiens	16-36
2290154-2	1990	Highly purified interleukin 1 (IL-1) (17 kDa) and recombinant IL-1 beta in the concentration range 0.2-20 U/ml released significant amounts of calcium.	Calcium	143-150	interleukin 1 beta	Homo sapiens	62-71
2126626-0	1990	Interleukin 1 beta modulation of TRH stimulated prolactin secretion and inositol phosphate production.	Inositol Phosphates	72-90	interleukin 1 beta	Homo sapiens	0-18
1696948-5	1990	Since the recruitment of stored ferritin mRNA onto polyribosomes is seen when iron enters the cell, the effect of IL-1 beta on iron uptake was tested and was found to be unaffected by the lymphokine.	Iron	127-131	interleukin 1 beta	Homo sapiens	114-123
2166111-0	1990	IL-1 binds to high affinity receptors on human osteosarcoma cells and potentiates prostaglandin E2 stimulation of cAMP production.	Dinoprostone	82-98	interleukin 1 beta	Homo sapiens	0-4
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 1 beta	Homo sapiens	99-118
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 1 beta	Homo sapiens	174-183
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 1 beta	Homo sapiens	114-118
2388269-0	1990	Low resolution structure of interleukin-1 beta in solution derived from 1H-15N heteronuclear three-dimensional nuclear magnetic resonance spectroscopy.	Hydrogen	72-74	interleukin 1 beta	Homo sapiens	28-46
2388269-0	1990	Low resolution structure of interleukin-1 beta in solution derived from 1H-15N heteronuclear three-dimensional nuclear magnetic resonance spectroscopy.	15n	75-78	interleukin 1 beta	Homo sapiens	28-46
2388269-1	1990	A low resolution solution structure of the cytokine interleukin-1 beta, a 153 residue protein of molecular weight 17,400, has been determined on the basis of 446 nuclear Overhauser effect (NOE) derived approximate interproton distance restraints involving solely NH, C alpha H and C beta H protons, supplemented by 90 distance restraints for 45 hydrogen bonds, and 79 phi torsion angle restraints.	Hydrogen	345-353	interleukin 1 beta	Homo sapiens	52-70
2203826-1	1990	Recombinant human IL 1 beta inhibits glucose-induced insulin secretion from isolated pancreatic islets and from purified beta-cells obtained by fluorescence-activated cell sorting (FACS) of dispersed islet cells.	Glucose	37-44	interleukin 1 beta	Homo sapiens	18-27
2169419-6	1990	In contrast to these results, cycloheximide did not induce collagenase mRNA but, rather, prevented its induction by interleukin-1 beta.	Cycloheximide	30-43	interleukin 1 beta	Homo sapiens	116-134
2166111-0	1990	IL-1 binds to high affinity receptors on human osteosarcoma cells and potentiates prostaglandin E2 stimulation of cAMP production.	Cyclic AMP	114-118	interleukin 1 beta	Homo sapiens	0-4
2166111-9	1990	Although IL-1 had no effect on PGE2 synthesis, both IL-1 alpha and IL-1 beta enhanced PGE2 stimulation of adenylate cyclase two- to four-fold in a dose-dependent manner.	Dinoprostone	86-90	interleukin 1 beta	Homo sapiens	67-76
2166111-12	1990	IL-1 enhancement of PGE2-stimulated adenylate cyclase was detected between 1 to 2 h, was maximal at 4 to 5 h, was not prevented by cycloheximide treatment, and was seen in membranes from IL-1 pretreated cells.	Dinoprostone	20-24	interleukin 1 beta	Homo sapiens	0-4
2166111-12	1990	IL-1 enhancement of PGE2-stimulated adenylate cyclase was detected between 1 to 2 h, was maximal at 4 to 5 h, was not prevented by cycloheximide treatment, and was seen in membranes from IL-1 pretreated cells.	Dinoprostone	20-24	interleukin 1 beta	Homo sapiens	187-191
2166111-12	1990	IL-1 enhancement of PGE2-stimulated adenylate cyclase was detected between 1 to 2 h, was maximal at 4 to 5 h, was not prevented by cycloheximide treatment, and was seen in membranes from IL-1 pretreated cells.	Cycloheximide	131-144	interleukin 1 beta	Homo sapiens	0-4
2115888-5	1990	Surprisingly, cell fractionation using cold (osmotic) shock indicated that proapoA-I, apoA-I, and IL-1 beta, but not its 31-kDa precursor, were segregated into the periplasmic space with high efficiency: the ratio of periplasmic space/spheroplast distribution ranged from 0.6 to 1.1 in cells harvested 60-180 min after nalidixic acid induction.	Nalidixic Acid	319-333	interleukin 1 beta	Homo sapiens	98-107
2383651-1	1990	We have previously reported that 20 hours" preincubation of human bone marrow cells with interleukin-1 beta (IL-1) can protect early progenitor cells from 4-hydroperoxycyclophosphamide (4-HC) cytotoxicity.	perfosfamide	186-190	interleukin 1 beta	Homo sapiens	89-107
2383651-1	1990	We have previously reported that 20 hours" preincubation of human bone marrow cells with interleukin-1 beta (IL-1) can protect early progenitor cells from 4-hydroperoxycyclophosphamide (4-HC) cytotoxicity.	perfosfamide	186-190	interleukin 1 beta	Homo sapiens	109-113
2383651-1	1990	We have previously reported that 20 hours" preincubation of human bone marrow cells with interleukin-1 beta (IL-1) can protect early progenitor cells from 4-hydroperoxycyclophosphamide (4-HC) cytotoxicity.	perfosfamide	155-184	interleukin 1 beta	Homo sapiens	89-107
2383651-1	1990	We have previously reported that 20 hours" preincubation of human bone marrow cells with interleukin-1 beta (IL-1) can protect early progenitor cells from 4-hydroperoxycyclophosphamide (4-HC) cytotoxicity.	perfosfamide	155-184	interleukin 1 beta	Homo sapiens	109-113
2223770-0	1990	Analysis of the backbone dynamics of interleukin-1 beta using two-dimensional inverse detected heteronuclear 15N-1H NMR spectroscopy.	15n	109-112	interleukin 1 beta	Homo sapiens	37-55
2223770-0	1990	Analysis of the backbone dynamics of interleukin-1 beta using two-dimensional inverse detected heteronuclear 15N-1H NMR spectroscopy.	Hydrogen	113-115	interleukin 1 beta	Homo sapiens	37-55
2223770-1	1990	The backbone dynamics of uniformly 15N-labeled interleukin-1 beta are investigated by using two-dimensional inverse detected heteronuclear 15N-1H NMR spectroscopy.	15n	35-38	interleukin 1 beta	Homo sapiens	47-65
2223770-1	1990	The backbone dynamics of uniformly 15N-labeled interleukin-1 beta are investigated by using two-dimensional inverse detected heteronuclear 15N-1H NMR spectroscopy.	15n	139-142	interleukin 1 beta	Homo sapiens	47-65
2223770-1	1990	The backbone dynamics of uniformly 15N-labeled interleukin-1 beta are investigated by using two-dimensional inverse detected heteronuclear 15N-1H NMR spectroscopy.	Hydrogen	143-145	interleukin 1 beta	Homo sapiens	47-65
2122226-7	1990	These studies demonstrated that combination therapy of CsA with steroid inhibits both gamma-IFN and IL-1 gene expression at the level of mRNA at physiological concentration.	Steroids	64-71	interleukin 1 beta	Homo sapiens	100-104
2116086-6	1990	Concentrations of PGE2 correlated significantly with PGI2, IL-1 beta, TNF, and lactate and inversely correlated with glucose concentrations in the first CSF specimens.	Dinoprostone	18-22	interleukin 1 beta	Homo sapiens	59-68
2116086-9	1990	Dexamethasone-treated patients had significantly lower PGE2, IL-1 beta, and lactate concentrations and higher glucose concentrations in CSF 18 to 30 hours later, shorter duration of fever, and a lower incidence of neurological sequelae than did placebo-treated patients.	Dexamethasone	0-13	interleukin 1 beta	Homo sapiens	61-70
2196229-9	1990	The majority of the IL-1-like factor with a low molecular weight in human gingival crevicular fluid migrated at a molecular weight of about 17,000 under the reducing conditions of sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	180-202	interleukin 1 beta	Homo sapiens	20-24
2196229-9	1990	The majority of the IL-1-like factor with a low molecular weight in human gingival crevicular fluid migrated at a molecular weight of about 17,000 under the reducing conditions of sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	polyacrylamide	203-217	interleukin 1 beta	Homo sapiens	20-24
2122226-7	1990	These studies demonstrated that combination therapy of CsA with steroid inhibits both gamma-IFN and IL-1 gene expression at the level of mRNA at physiological concentration.	Cyclosporine	55-58	interleukin 1 beta	Homo sapiens	100-104
2377896-2	1990	The power of this technique is demonstrated by the application of four-dimensional carbon-13--nitrogen-15 (13C-15N)--edited nuclear Overhauser effect (NOE) spectroscopy to interleukin-1 beta, a protein of 153 residues.	Carbon-13	83-94	interleukin 1 beta	Homo sapiens	172-190
2171043-7	1990	However, in cells labelled with [3H]glycerol or [3H]arachidonic acid, IL-1 beta caused an immediate rise in diglyceride (DG) accumulation.	[3h]glycerol	32-44	interleukin 1 beta	Homo sapiens	70-79
2171043-7	1990	However, in cells labelled with [3H]glycerol or [3H]arachidonic acid, IL-1 beta caused an immediate rise in diglyceride (DG) accumulation.	[3h]arachidonic acid	48-68	interleukin 1 beta	Homo sapiens	70-79
2171043-7	1990	However, in cells labelled with [3H]glycerol or [3H]arachidonic acid, IL-1 beta caused an immediate rise in diglyceride (DG) accumulation.	Diglycerides	108-119	interleukin 1 beta	Homo sapiens	70-79
2171043-8	1990	As the effects of IL-1 beta have been reported to be mimicked by tumour-promoting phorbol esters, this rise in DG suggested the involvement of protein kinase C (PKC).	Phorbol Esters	82-96	interleukin 1 beta	Homo sapiens	18-27
2171043-11	1990	Rather, IL-1 beta appeared to increase the synthesis of PKC in both membrane and cytosol preparations, an effect which could be prevented by coincubation with cycloheximide.	Cycloheximide	159-172	interleukin 1 beta	Homo sapiens	8-17
2171043-12	1990	These findings suggest that the diglyceride formed in response to IL-1 beta does not activate protein kinase C.	Diglycerides	32-43	interleukin 1 beta	Homo sapiens	66-75
2377896-2	1990	The power of this technique is demonstrated by the application of four-dimensional carbon-13--nitrogen-15 (13C-15N)--edited nuclear Overhauser effect (NOE) spectroscopy to interleukin-1 beta, a protein of 153 residues.	Nitrogen	94-102	interleukin 1 beta	Homo sapiens	172-190
2377896-2	1990	The power of this technique is demonstrated by the application of four-dimensional carbon-13--nitrogen-15 (13C-15N)--edited nuclear Overhauser effect (NOE) spectroscopy to interleukin-1 beta, a protein of 153 residues.	13c-15n	107-114	interleukin 1 beta	Homo sapiens	172-190
2104229-2	1990	PGE2 release by IL 1 beta-stimulated RA synovial cells grown for 14 days in serum-free RPMI was significantly less than that released by the same cells grown in medium plus 10% FBS (p less than 0.03; two-tailed).	Dinoprostone	0-4	interleukin 1 beta	Homo sapiens	16-25
2390678-16	1990	The different potencies of IL-l alpha and IL-1 beta may be related to their relative ability to stimulate prostanoid biosynthesis.	Prostaglandins	106-116	interleukin 1 beta	Homo sapiens	42-51
2390678-11	1990	A cyclo-oxygenase inhibitor, ketoprofen (3 mg kg-1) administered 15 min before either cytokine completely abolished the fever induced by both IL-1 alpha (2500 u kg-1) and IL-1 beta (500 u kg-1).	Ketoprofen	29-39	interleukin 1 beta	Homo sapiens	171-180
2390678-13	1990	Intravenous administration of the steroidal anti-inflammatory agent dexamethasone (3 mg kg-1) 1 h before either cytokine attenuated the fever induced by IL-1 alpha (2500 u kg-1) and IL-1 beta (500 u kg-1).	Dexamethasone	68-81	interleukin 1 beta	Homo sapiens	182-191
2104229-2	1990	PGE2 release by IL 1 beta-stimulated RA synovial cells grown for 14 days in serum-free RPMI was significantly less than that released by the same cells grown in medium plus 10% FBS (p less than 0.03; two-tailed).	rpmi	87-91	interleukin 1 beta	Homo sapiens	16-25
2104229-4	1990	Both EGF and bFGF significantly enhanced IL 1 beta-induced release of PGE2 (p less than 0.05; paired t test, one-tailed), while PDGF was synergistic with IL 1 beta, significantly increasing release of PGE2 by these cultured cells (p less than 0.02; two-tailed).	Dinoprostone	70-74	interleukin 1 beta	Homo sapiens	41-50
2104229-4	1990	Both EGF and bFGF significantly enhanced IL 1 beta-induced release of PGE2 (p less than 0.05; paired t test, one-tailed), while PDGF was synergistic with IL 1 beta, significantly increasing release of PGE2 by these cultured cells (p less than 0.02; two-tailed).	Dinoprostone	201-205	interleukin 1 beta	Homo sapiens	41-50
2104229-4	1990	Both EGF and bFGF significantly enhanced IL 1 beta-induced release of PGE2 (p less than 0.05; paired t test, one-tailed), while PDGF was synergistic with IL 1 beta, significantly increasing release of PGE2 by these cultured cells (p less than 0.02; two-tailed).	Dinoprostone	201-205	interleukin 1 beta	Homo sapiens	154-163
1698759-1	1990	The capacity of minocycline and tetracycline for modulation of IL-1 secretion by LPS-stimulated human monocytes was investigated in vitro.	Minocycline	16-27	interleukin 1 beta	Homo sapiens	63-67
1698759-1	1990	The capacity of minocycline and tetracycline for modulation of IL-1 secretion by LPS-stimulated human monocytes was investigated in vitro.	Tetracycline	32-44	interleukin 1 beta	Homo sapiens	63-67
1698759-3	1990	IL-1 beta secretion by LPS-stimulated human monocytes cultured for 24h at 1 x 10(6)/ml with 0, 5, 10 and 50 mg/l minocycline or tetracycline was therefore determined by ELISA.	Minocycline	113-124	interleukin 1 beta	Homo sapiens	0-9
2162889-2	1990	The density of beta AR, assayed by 125I-pindolol binding, was increased two- to threefold by a 24-h incubation of the cells with IL-1 alpha, IL-1 beta, and TNF-alpha (EC50: 2.7, 8.2, and 24 pM, respectively), although a series of other cytokines and growth factors did not have this effect.	125i-pindolol	35-48	interleukin 1 beta	Homo sapiens	141-150
2162889-5	1990	The IL-1-induced increase in beta AR density was half-maximal after 6 h, was reversible at a similar rate, and was blocked by 1 microM of cycloheximide.	Cycloheximide	138-151	interleukin 1 beta	Homo sapiens	4-8
2162889-6	1990	The effect of IL-1 on beta AR was specific, as the density of glucocorticoid receptors, measured by 3H-dexamethasone binding, was reduced by IL-1.	3h-dexamethasone	100-116	interleukin 1 beta	Homo sapiens	14-18
2162889-6	1990	The effect of IL-1 on beta AR was specific, as the density of glucocorticoid receptors, measured by 3H-dexamethasone binding, was reduced by IL-1.	3h-dexamethasone	100-116	interleukin 1 beta	Homo sapiens	141-145
2162889-7	1990	Both cortisol and IL-1 potentiated the isoproterenol-induced increase in cAMP accumulation.	Isoproterenol	39-52	interleukin 1 beta	Homo sapiens	18-22
2162889-7	1990	Both cortisol and IL-1 potentiated the isoproterenol-induced increase in cAMP accumulation.	Cyclic AMP	73-77	interleukin 1 beta	Homo sapiens	18-22
2162889-8	1990	IL-1 inhibited cell proliferation and thymidine uptake, and increased the adherence of A549 cells to the plastic culture flask, as quantified by a cell detachment assay.	Thymidine	38-47	interleukin 1 beta	Homo sapiens	0-4
2195296-3	1990	The rates of glucose appearance (Ra) and disappearance (Rd) were elevated only with IL-1 and were associated with an increase in glucagon and a concomitant decrease in the ratio of insulin to glucagon.	Glucose	13-20	interleukin 1 beta	Homo sapiens	84-88
2110990-6	1990	IL-4 can also suppress the increased release of IL-1 beta and TNF alpha by monocytes incubated with indomethacin, a non-steroidal anti-inflammatory drug.	Indomethacin	100-112	interleukin 1 beta	Homo sapiens	48-57
2195296-4	1990	Plasma glucose concentration was increased early after IL-1 administration and coincided with the peak in the Ra.	Glucose	7-14	interleukin 1 beta	Homo sapiens	55-59
2195296-5	1990	The augmentation of the metabolic clearance rate (MCR) and percent of flux oxidized by IL-1 suggest that this monokine induces the utilization of glucose as a substrate.	Glucose	146-153	interleukin 1 beta	Homo sapiens	87-91
2164143-0	1990	Production of interleukin-1 beta by periodic acid-oxidized human peripheral blood mononuclear cells.	Periodic Acid	36-49	interleukin 1 beta	Homo sapiens	14-32
2164143-3	1990	Thymocyte proliferation, driven by periodic acid-induced IL-1, was abolished by an antibody to IL-1 alpha and IL-1 beta.	Periodic Acid	35-48	interleukin 1 beta	Homo sapiens	110-119
2383553-0	1990	Identification and localization of bound internal water in the solution structure of interleukin 1 beta by heteronuclear three-dimensional 1H rotating-frame Overhauser 15N-1H multiple quantum coherence NMR spectroscopy.	Water	50-55	interleukin 1 beta	Homo sapiens	85-103
2164143-5	1990	Partial characterization of H5IO6-induced IL-1 beta indicated that it was identical to IL-1 produced by lipopolysaccharide-stimulated macrophages.	Periodic Acid	28-33	interleukin 1 beta	Homo sapiens	42-51
2383553-0	1990	Identification and localization of bound internal water in the solution structure of interleukin 1 beta by heteronuclear three-dimensional 1H rotating-frame Overhauser 15N-1H multiple quantum coherence NMR spectroscopy.	Hydrogen	139-141	interleukin 1 beta	Homo sapiens	85-103
1693528-6	1990	Furthermore, mRNA for IL-6 and IL-1 beta was dramatically superinduced by the combination of cycloheximide and TNF alpha.	Cycloheximide	93-106	interleukin 1 beta	Homo sapiens	31-40
2164143-6	1990	It is concluded that oxidation of human PBMN cells by H5IO6 triggers synthesis and release of IL-1, most of which was in its IL-1 beta form.	Periodic Acid	54-59	interleukin 1 beta	Homo sapiens	125-134
2383553-0	1990	Identification and localization of bound internal water in the solution structure of interleukin 1 beta by heteronuclear three-dimensional 1H rotating-frame Overhauser 15N-1H multiple quantum coherence NMR spectroscopy.	15n	168-171	interleukin 1 beta	Homo sapiens	85-103
1693636-8	1990	The anti-LFA-3-mediated augmentation of IL-1 release required both new protein and RNA synthesis as shown by the ability of cycloheximide and actinomycin-D to inhibit augmentation of IL-1 production by TE cells, and by direct quantitation of IL-1 alpha and IL-1 beta mRNA by Northern blot analysis.	Cycloheximide	124-137	interleukin 1 beta	Homo sapiens	40-44
2383553-0	1990	Identification and localization of bound internal water in the solution structure of interleukin 1 beta by heteronuclear three-dimensional 1H rotating-frame Overhauser 15N-1H multiple quantum coherence NMR spectroscopy.	Hydrogen	172-174	interleukin 1 beta	Homo sapiens	85-103
2383553-1	1990	The presence and location of bound internal water molecules in the solution structure of interleukin 1 beta have been investigated by means of three-dimensional 1H rotating-frame Overhauser 1H-15N multiple quantum coherence spectroscopy (ROESY-HMQC).	Water	44-49	interleukin 1 beta	Homo sapiens	89-107
2383553-1	1990	The presence and location of bound internal water molecules in the solution structure of interleukin 1 beta have been investigated by means of three-dimensional 1H rotating-frame Overhauser 1H-15N multiple quantum coherence spectroscopy (ROESY-HMQC).	Hydrogen	161-163	interleukin 1 beta	Homo sapiens	89-107
2383553-1	1990	The presence and location of bound internal water molecules in the solution structure of interleukin 1 beta have been investigated by means of three-dimensional 1H rotating-frame Overhauser 1H-15N multiple quantum coherence spectroscopy (ROESY-HMQC).	Hydrogen	190-192	interleukin 1 beta	Homo sapiens	89-107
2383553-1	1990	The presence and location of bound internal water molecules in the solution structure of interleukin 1 beta have been investigated by means of three-dimensional 1H rotating-frame Overhauser 1H-15N multiple quantum coherence spectroscopy (ROESY-HMQC).	15n	193-196	interleukin 1 beta	Homo sapiens	89-107
2383553-4	1990	By this means, the problems that prevent, in all but a very few limited cases, the interpretation, identification, and assignment of ROE peaks between NH protons and water in a 2D 1H-1H ROESY spectrum of a large protein such as interleukin 1 beta, namely, extensive NH chemical shift degeneracy and ROE peaks obscured by much stronger chemical exchange peaks, are completely circumvented.	Water	166-171	interleukin 1 beta	Homo sapiens	228-246
2383553-4	1990	By this means, the problems that prevent, in all but a very few limited cases, the interpretation, identification, and assignment of ROE peaks between NH protons and water in a 2D 1H-1H ROESY spectrum of a large protein such as interleukin 1 beta, namely, extensive NH chemical shift degeneracy and ROE peaks obscured by much stronger chemical exchange peaks, are completely circumvented.	Hydrogen	180-182	interleukin 1 beta	Homo sapiens	228-246
2383553-4	1990	By this means, the problems that prevent, in all but a very few limited cases, the interpretation, identification, and assignment of ROE peaks between NH protons and water in a 2D 1H-1H ROESY spectrum of a large protein such as interleukin 1 beta, namely, extensive NH chemical shift degeneracy and ROE peaks obscured by much stronger chemical exchange peaks, are completely circumvented.	Hydrogen	183-185	interleukin 1 beta	Homo sapiens	228-246
2383553-8	1990	209, 779-791], the results can be attributed to 11 water molecules that are involved in interactions bridging hydrogen-bonding interactions with backbone amide and carbonyl groups which stabilize the 3-fold pseudosymmetric topology of interleukin 1 beta and thus constitute an integral part of the protein structure in solution.	Water	51-56	interleukin 1 beta	Homo sapiens	235-253
2383553-8	1990	209, 779-791], the results can be attributed to 11 water molecules that are involved in interactions bridging hydrogen-bonding interactions with backbone amide and carbonyl groups which stabilize the 3-fold pseudosymmetric topology of interleukin 1 beta and thus constitute an integral part of the protein structure in solution.	Hydrogen	110-118	interleukin 1 beta	Homo sapiens	235-253
2383553-8	1990	209, 779-791], the results can be attributed to 11 water molecules that are involved in interactions bridging hydrogen-bonding interactions with backbone amide and carbonyl groups which stabilize the 3-fold pseudosymmetric topology of interleukin 1 beta and thus constitute an integral part of the protein structure in solution.	Amides	154-159	interleukin 1 beta	Homo sapiens	235-253
1693636-4	1990	Both autologous and allogenic emetine-treated thymocytes when cultured with TE cells augmented IL-1 release by TE cells.	Emetine	30-37	interleukin 1 beta	Homo sapiens	95-99
1693636-8	1990	The anti-LFA-3-mediated augmentation of IL-1 release required both new protein and RNA synthesis as shown by the ability of cycloheximide and actinomycin-D to inhibit augmentation of IL-1 production by TE cells, and by direct quantitation of IL-1 alpha and IL-1 beta mRNA by Northern blot analysis.	Cycloheximide	124-137	interleukin 1 beta	Homo sapiens	183-187
1693636-8	1990	The anti-LFA-3-mediated augmentation of IL-1 release required both new protein and RNA synthesis as shown by the ability of cycloheximide and actinomycin-D to inhibit augmentation of IL-1 production by TE cells, and by direct quantitation of IL-1 alpha and IL-1 beta mRNA by Northern blot analysis.	Cycloheximide	124-137	interleukin 1 beta	Homo sapiens	257-266
1693636-8	1990	The anti-LFA-3-mediated augmentation of IL-1 release required both new protein and RNA synthesis as shown by the ability of cycloheximide and actinomycin-D to inhibit augmentation of IL-1 production by TE cells, and by direct quantitation of IL-1 alpha and IL-1 beta mRNA by Northern blot analysis.	Dactinomycin	142-155	interleukin 1 beta	Homo sapiens	40-44
1693636-8	1990	The anti-LFA-3-mediated augmentation of IL-1 release required both new protein and RNA synthesis as shown by the ability of cycloheximide and actinomycin-D to inhibit augmentation of IL-1 production by TE cells, and by direct quantitation of IL-1 alpha and IL-1 beta mRNA by Northern blot analysis.	Dactinomycin	142-155	interleukin 1 beta	Homo sapiens	183-187
1693636-8	1990	The anti-LFA-3-mediated augmentation of IL-1 release required both new protein and RNA synthesis as shown by the ability of cycloheximide and actinomycin-D to inhibit augmentation of IL-1 production by TE cells, and by direct quantitation of IL-1 alpha and IL-1 beta mRNA by Northern blot analysis.	Dactinomycin	142-155	interleukin 1 beta	Homo sapiens	257-266
2334910-4	1990	With either TNF or IL-1 beta as the stimulus, TNF mRNA is induced first, peaks within 1-3 h, and declines to nearly undetectable levels by 9 h. TNF mRNA accumulation is enhanced in the presence of cycloheximide indicating that de novo protein synthesis is not required for maximal TNF mRNA induction.	Cycloheximide	197-210	interleukin 1 beta	Homo sapiens	19-28
2160861-0	1990	Quinolone-induced differential modification of IL-1 alpha and IL-1 beta production by LPS-stimulated human monocytes.	Quinolones	0-9	interleukin 1 beta	Homo sapiens	62-71
2160861-1	1990	We previously reported that ciprofloxacin (Cip), a quinoline-derivative antibiotic, decreases the biological activity of IL-1 released by LPS-stimulated monocytes after 24 hr of culture without affecting cell-associated IL-1 activity.	Ciprofloxacin	28-41	interleukin 1 beta	Homo sapiens	121-125
2160861-1	1990	We previously reported that ciprofloxacin (Cip), a quinoline-derivative antibiotic, decreases the biological activity of IL-1 released by LPS-stimulated monocytes after 24 hr of culture without affecting cell-associated IL-1 activity.	Ciprofloxacin	43-46	interleukin 1 beta	Homo sapiens	121-125
2334910-5	1990	In contrast, IL-1 beta mRNA is induced later, peaks at 3-9 h, and remains considerably elevated at 18 h. IL-1 beta mRNA accumulation is partially suppressed in the presence of cycloheximide.	Cycloheximide	176-189	interleukin 1 beta	Homo sapiens	13-22
2160861-1	1990	We previously reported that ciprofloxacin (Cip), a quinoline-derivative antibiotic, decreases the biological activity of IL-1 released by LPS-stimulated monocytes after 24 hr of culture without affecting cell-associated IL-1 activity.	Ciprofloxacin	43-46	interleukin 1 beta	Homo sapiens	220-224
2160861-1	1990	We previously reported that ciprofloxacin (Cip), a quinoline-derivative antibiotic, decreases the biological activity of IL-1 released by LPS-stimulated monocytes after 24 hr of culture without affecting cell-associated IL-1 activity.	quinoline	51-60	interleukin 1 beta	Homo sapiens	121-125
2334910-5	1990	In contrast, IL-1 beta mRNA is induced later, peaks at 3-9 h, and remains considerably elevated at 18 h. IL-1 beta mRNA accumulation is partially suppressed in the presence of cycloheximide.	Cycloheximide	176-189	interleukin 1 beta	Homo sapiens	105-114
2160861-3	1990	Cip had a post-transcriptional differential effect on the production of IL-1 alpha and IL-1 beta, reducing the total amount of IL-1 beta produced by LPS-stimulated monocytes, while that of IL-1 alpha was unaffected.	Ciprofloxacin	0-3	interleukin 1 beta	Homo sapiens	87-96
2112152-8	1990	Although the main mechanism of 131I uptake suppression in the thyroid gland in subacute thyroiditis is due to cellular damage and suppression of TSH release, our present findings suggest that IL-1, TNF alpha, and IFN gamma produced in the inflammatory process within the thyroid gland further inhibit iodine incorporation and at least partly account for the decreased 131I uptake by the thyroid gland in destruction-induced hyperthyroidism.	Iodine	301-307	interleukin 1 beta	Homo sapiens	192-196
2160861-3	1990	Cip had a post-transcriptional differential effect on the production of IL-1 alpha and IL-1 beta, reducing the total amount of IL-1 beta produced by LPS-stimulated monocytes, while that of IL-1 alpha was unaffected.	Ciprofloxacin	0-3	interleukin 1 beta	Homo sapiens	127-136
2160861-5	1990	These findings explain the discrepancy between the Cip-induced alteration of extracellular IL-1 activity and the preservation of cell-associated activity.	Ciprofloxacin	51-54	interleukin 1 beta	Homo sapiens	91-95
2160861-6	1990	Cip is, to our knowledge, the first pharmacological agent found to have a differential effect on the synthesis of IL-1 alpha and IL-1 beta.	Ciprofloxacin	0-3	interleukin 1 beta	Homo sapiens	129-138
2350191-2	1990	The direct effect of recombinant human IL-1 beta (rHuIL-1 beta) on cultured U-373 MG glioma cell was evaluated in vitro by BrdU uptake assay, and these effects were compared with those of human interferon beta (HuIFN-beta).	Bromodeoxyuridine	123-127	interleukin 1 beta	Homo sapiens	39-48
2112152-3	1990	IL-1 alpha and IL-1 beta inhibited 125I incorporation and [125I]iodothyronine release in a concentration-dependent manner.	Iodine-125	35-39	interleukin 1 beta	Homo sapiens	15-24
2112152-8	1990	Although the main mechanism of 131I uptake suppression in the thyroid gland in subacute thyroiditis is due to cellular damage and suppression of TSH release, our present findings suggest that IL-1, TNF alpha, and IFN gamma produced in the inflammatory process within the thyroid gland further inhibit iodine incorporation and at least partly account for the decreased 131I uptake by the thyroid gland in destruction-induced hyperthyroidism.	Iodine-131	368-372	interleukin 1 beta	Homo sapiens	192-196
2112152-3	1990	IL-1 alpha and IL-1 beta inhibited 125I incorporation and [125I]iodothyronine release in a concentration-dependent manner.	iodothyronine	64-77	interleukin 1 beta	Homo sapiens	15-24
1716487-2	1990	In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes.	Dinoprostone	40-56	interleukin 1 beta	Homo sapiens	211-220
2112152-8	1990	Although the main mechanism of 131I uptake suppression in the thyroid gland in subacute thyroiditis is due to cellular damage and suppression of TSH release, our present findings suggest that IL-1, TNF alpha, and IFN gamma produced in the inflammatory process within the thyroid gland further inhibit iodine incorporation and at least partly account for the decreased 131I uptake by the thyroid gland in destruction-induced hyperthyroidism.	Iodine-131	31-35	interleukin 1 beta	Homo sapiens	192-196
2372550-0	1990	Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy.	15n	137-140	interleukin 1 beta	Homo sapiens	67-85
2372550-0	1990	Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy.	Hydrogen	141-143	interleukin 1 beta	Homo sapiens	67-85
2372550-4	1990	Amide NH solvent exchange rates have been measured by following the time dependence of the 15N-1H correlation spectrum of interleukin-1 beta on dissolving the protein in D2O solution.	Amides	0-5	interleukin 1 beta	Homo sapiens	122-140
2372550-4	1990	Amide NH solvent exchange rates have been measured by following the time dependence of the 15N-1H correlation spectrum of interleukin-1 beta on dissolving the protein in D2O solution.	15n-1h	91-97	interleukin 1 beta	Homo sapiens	122-140
2372550-4	1990	Amide NH solvent exchange rates have been measured by following the time dependence of the 15N-1H correlation spectrum of interleukin-1 beta on dissolving the protein in D2O solution.	Deuterium Oxide	170-173	interleukin 1 beta	Homo sapiens	122-140
1716487-2	1990	In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes.	dibutyryl	102-111	interleukin 1 beta	Homo sapiens	211-220
1694134-1	1990	Serum-free culture of human monocytes in the presence of monoclonal antibodies to the LFA-1 alpha chain (CD11a), CR3 alpha chain (CD11b) or beta chain (CD18) bound to Sepharose induced the dose-dependent production of cell-associated interleukin (IL) 1 activity and of IL 1 alpha and IL 1 beta antigens, but no release of extracellular IL 1 activity or antigen in the culture medium.	Sepharose	167-176	interleukin 1 beta	Homo sapiens	284-293
1716487-2	1990	In this study, we report the effects of prostaglandin E2 (PGE2), and two other cAMP-elevating agents, dibutyryl cAMP and 3-isobutyl-1-methyl-xanthine, on the in vitro LPS-induced production of IL 6, IL 1 alpha, IL 1 beta and TNF alpha by human monocytes.	1-Methyl-3-isobutylxanthine	121-149	interleukin 1 beta	Homo sapiens	211-220
1716487-8	1990	These results demonstrate that IL 6, TNF alpha, IL 1 alpha and IL 1 beta production can be differently modulated by an agent, PGE2, which is produced simultaneously by LPS-stimulated monocytes.	Dinoprostone	126-130	interleukin 1 beta	Homo sapiens	63-72
2139669-6	1990	The recombinant IL-1ra also blocks IL-1 alpha and IL-1 beta stimulation of PGE2 production in human synovial cells and rabbit articular chondrocytes, and of collagenase production by the synovial cells.	Dinoprostone	75-79	interleukin 1 beta	Homo sapiens	50-59
2328723-6	1990	Secretion of IL-1 beta is blocked by methylamine, low temperature or serum free medium, and is increased by raising the culture temperature to 42 degrees C or by the presence of calcium ionophores, brefeldin A, monensin, dinitrophenol or carbonyl cyanide chlorophenylhydrazone.	methylamine	37-48	interleukin 1 beta	Homo sapiens	13-22
2328723-6	1990	Secretion of IL-1 beta is blocked by methylamine, low temperature or serum free medium, and is increased by raising the culture temperature to 42 degrees C or by the presence of calcium ionophores, brefeldin A, monensin, dinitrophenol or carbonyl cyanide chlorophenylhydrazone.	Calcium	178-185	interleukin 1 beta	Homo sapiens	13-22
2328723-6	1990	Secretion of IL-1 beta is blocked by methylamine, low temperature or serum free medium, and is increased by raising the culture temperature to 42 degrees C or by the presence of calcium ionophores, brefeldin A, monensin, dinitrophenol or carbonyl cyanide chlorophenylhydrazone.	Brefeldin A	198-209	interleukin 1 beta	Homo sapiens	13-22
2328723-6	1990	Secretion of IL-1 beta is blocked by methylamine, low temperature or serum free medium, and is increased by raising the culture temperature to 42 degrees C or by the presence of calcium ionophores, brefeldin A, monensin, dinitrophenol or carbonyl cyanide chlorophenylhydrazone.	Monensin	211-219	interleukin 1 beta	Homo sapiens	13-22
2328723-6	1990	Secretion of IL-1 beta is blocked by methylamine, low temperature or serum free medium, and is increased by raising the culture temperature to 42 degrees C or by the presence of calcium ionophores, brefeldin A, monensin, dinitrophenol or carbonyl cyanide chlorophenylhydrazone.	Dinitrophenols	221-234	interleukin 1 beta	Homo sapiens	13-22
2328723-6	1990	Secretion of IL-1 beta is blocked by methylamine, low temperature or serum free medium, and is increased by raising the culture temperature to 42 degrees C or by the presence of calcium ionophores, brefeldin A, monensin, dinitrophenol or carbonyl cyanide chlorophenylhydrazone.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	238-276	interleukin 1 beta	Homo sapiens	13-22
2335234-4	1990	In organ cultures resembling closely the in vivo system 10(6) chondrocytes incubated with 100 units of interleukin-1 beta per ml of medium led to the release of 6 X 10(3) units of IL-6 within 24 h. Chondrocytes cultured in agarose or as monolayers similarly incubated with IL-1 beta produced even higher amounts of IL-6: 70 X 10(3) units per 10(6) cells within 24 h. The induction of IL-6 synthesis by IL-1 beta was also shown at the mRNA level.	Sepharose	223-230	interleukin 1 beta	Homo sapiens	103-121
2138916-1	1990	The effect of tumor-promoting phorbol ester treatment on the binding of interleukin-1 beta (IL-1 beta) to specific cell surface receptors was investigated.	Phorbol Esters	30-43	interleukin 1 beta	Homo sapiens	72-90
2156847-3	1990	Elastase, collagenase, and cathepsin G cleaved the IL1 beta precursor at distinct sites which are amino-terminal to the monocyte-processing site, Ala-117 (Cameron, P., Lumjuco, G., Rodkey, J., Bennett, C., and Schmidt, J.	ala-117	146-153	interleukin 1 beta	Homo sapiens	51-59
2138916-1	1990	The effect of tumor-promoting phorbol ester treatment on the binding of interleukin-1 beta (IL-1 beta) to specific cell surface receptors was investigated.	Phorbol Esters	30-43	interleukin 1 beta	Homo sapiens	92-101
2138916-2	1990	A 1 h exposure of Raji human B lymphoma cells with the protein kinase C-activating phorbol ester, phorbol dibutyrate (PDBu), reduced IL-1 beta binding by up to 90% of control cells.	Phorbol Esters	83-96	interleukin 1 beta	Homo sapiens	133-142
2158905-0	1990	Modulation of interleukin-1 beta production by cyclic AMP in human monocytes.	Cyclic AMP	47-57	interleukin 1 beta	Homo sapiens	14-32
2138916-2	1990	A 1 h exposure of Raji human B lymphoma cells with the protein kinase C-activating phorbol ester, phorbol dibutyrate (PDBu), reduced IL-1 beta binding by up to 90% of control cells.	Phorbol 12,13-Dibutyrate	98-116	interleukin 1 beta	Homo sapiens	133-142
2158905-1	1990	Elevation of cAMP has been considered to be an important downregulative signal in the production of interleukin-1(IL-1).	Cyclic AMP	13-17	interleukin 1 beta	Homo sapiens	114-118
2138916-2	1990	A 1 h exposure of Raji human B lymphoma cells with the protein kinase C-activating phorbol ester, phorbol dibutyrate (PDBu), reduced IL-1 beta binding by up to 90% of control cells.	Phorbol 12,13-Dibutyrate	118-122	interleukin 1 beta	Homo sapiens	133-142
2158905-3	1990	The IL-1 beta production of lipopolysaccharide activated human monocytes was readily inhibited by dibutyryl cAMP.	Bucladesine	98-112	interleukin 1 beta	Homo sapiens	4-13
2138916-4	1990	Analysis of 125I-labeled IL-1 beta binding to intact cells revealed that PDBu caused a 91% decrease in high-affinity cell-surface receptor number without an effect on receptor affinity.	Iodine-125	12-16	interleukin 1 beta	Homo sapiens	25-34
2158905-5	1990	By contrast, in PMA activated monocytes 100 microM dibutyryl cAMP increased in IL-1 beta production ca.	dibutyryl	51-60	interleukin 1 beta	Homo sapiens	79-88
2158905-5	1990	By contrast, in PMA activated monocytes 100 microM dibutyryl cAMP increased in IL-1 beta production ca.	Cyclic AMP	61-65	interleukin 1 beta	Homo sapiens	79-88
2138916-6	1990	The PDBu-induced decrease in IL-1 beta receptor number was inhibited by prior incubation of cells for 30 min with the PKC inhibitor 1-(5-Isoquinoline sulfonyl)-2-methylpiperazine (H7).	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	132-178	interleukin 1 beta	Homo sapiens	29-38
2346722-2	1990	Recombinant human (rh) IL-1 alpha, IL-1 beta and TNF-alpha augmented production of IL-6 in human MC.	Methylcholanthrene	97-99	interleukin 1 beta	Homo sapiens	35-44
1695452-4	1990	IL-1 alpha, IL-1 beta, IL-3, colony stimulating factor (CSF) and granulocyte-macrophage-CSF (GM-CSF) caused significant histamine release from cells from a similar number of AIDS patients and controls.	Histamine	120-129	interleukin 1 beta	Homo sapiens	12-21
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	15n	49-52	interleukin 1 beta	Homo sapiens	121-139
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	Hydrogen	57-59	interleukin 1 beta	Homo sapiens	121-139
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	15n	205-208	interleukin 1 beta	Homo sapiens	121-139
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	Hydrogen	209-211	interleukin 1 beta	Homo sapiens	121-139
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	15n	205-208	interleukin 1 beta	Homo sapiens	121-139
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	Hydrogen	209-211	interleukin 1 beta	Homo sapiens	121-139
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	Hydrogen	209-211	interleukin 1 beta	Homo sapiens	121-139
2354151-4	1990	A doubling of some peaks in the spectrum was found to be due to N-terminal heterogeneity of the 15N-labeled protein, corresponding to a mixture of wild-type and des-Ala-1-interleukin 1 beta.	15n	96-99	interleukin 1 beta	Homo sapiens	171-189
2346722-6	1990	IL-1 alpha, IL-1 beta and TNF-alpha enhanced 3H-TdR uptake in myeloma cells through IL-6, as antibodies to IL-6 completely abolished the DNA synthesis induced by culture supernatants of MC exposed to these cytokines.	Tritium	45-47	interleukin 1 beta	Homo sapiens	12-21
2346722-6	1990	IL-1 alpha, IL-1 beta and TNF-alpha enhanced 3H-TdR uptake in myeloma cells through IL-6, as antibodies to IL-6 completely abolished the DNA synthesis induced by culture supernatants of MC exposed to these cytokines.	Methylcholanthrene	186-188	interleukin 1 beta	Homo sapiens	12-21
2346722-11	1990	The stimulatory activities of MC appeared to be mediated through endogenously released IL-1, as the addition of antibodies towards IL-1 at the initiation of cocultures completely abrogated the IL-6 production.	Methylcholanthrene	30-32	interleukin 1 beta	Homo sapiens	87-91
2346722-11	1990	The stimulatory activities of MC appeared to be mediated through endogenously released IL-1, as the addition of antibodies towards IL-1 at the initiation of cocultures completely abrogated the IL-6 production.	Methylcholanthrene	30-32	interleukin 1 beta	Homo sapiens	131-135
2157662-0	1990	Recombinant interleukin-1 beta interacts with high-affinity receptors to activate neutrophil leukotriene B4 synthesis.	Leukotriene B4	93-107	interleukin 1 beta	Homo sapiens	12-30
2157662-12	1990	In conclusion, recombinant IL-1 beta interacts with neutrophils through the presence on the PMN of a high-affinity receptor and results in the secretion of arachidonate metabolites.	Arachidonic Acid	156-168	interleukin 1 beta	Homo sapiens	27-36
2111375-0	1990	Secretion of interleukin-1 beta by a leukemia cell line in response to lipopolysaccharide and mezerein.	mezerein	94-102	interleukin 1 beta	Homo sapiens	13-31
2111375-5	1990	Silica-enhanced release of IL-1 was related to changes in cell membrane permeability.	Silicon Dioxide	0-6	interleukin 1 beta	Homo sapiens	27-31
2111375-7	1990	In contrast, mezerein stimulation led to higher extracellular concentrations of IL-1 beta and rIFN gamma augmented secretion by mezerein-treated cells.	mezerein	13-21	interleukin 1 beta	Homo sapiens	80-89
2182947-0	1990	Modulation of interleukin 1 beta gene expression using antisense phosphorothioate oligonucleotides.	Phosphorothioate Oligonucleotides	65-98	interleukin 1 beta	Homo sapiens	14-32
2182947-1	1990	The production of interleukin 1 beta (IL1 beta) in lipopolysaccharide (LPS) stimulated monocytes was inhibited by 98% using antisense phosphorothioate oligonucleotides complementary to the 5" untranslated and exon 6 regions of IL1 beta mRNA.	Phosphorothioate Oligonucleotides	134-167	interleukin 1 beta	Homo sapiens	18-36
2182947-1	1990	The production of interleukin 1 beta (IL1 beta) in lipopolysaccharide (LPS) stimulated monocytes was inhibited by 98% using antisense phosphorothioate oligonucleotides complementary to the 5" untranslated and exon 6 regions of IL1 beta mRNA.	Phosphorothioate Oligonucleotides	134-167	interleukin 1 beta	Homo sapiens	38-46
2182947-1	1990	The production of interleukin 1 beta (IL1 beta) in lipopolysaccharide (LPS) stimulated monocytes was inhibited by 98% using antisense phosphorothioate oligonucleotides complementary to the 5" untranslated and exon 6 regions of IL1 beta mRNA.	Phosphorothioate Oligonucleotides	134-167	interleukin 1 beta	Homo sapiens	227-235
2310829-6	1990	As judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, IL-6 species of relative molecular mass of 19 to 26 Kd could be specifically immunoprecipitated from supernatants of IL-1-induced monocytes.	Sodium Dodecyl Sulfate	13-35	interleukin 1 beta	Homo sapiens	215-219
2138199-1	1990	Selective biotinylation of human interleukin-1 beta was achieved by reaction of an interleukin-1 beta mutant protein containing a surface-accessible cysteine with maleimido-biotin.	Cysteine	149-157	interleukin 1 beta	Homo sapiens	33-51
2107032-2	1990	The secretion of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) was inhibited by copper under the same culture conditions, while zinc stimulated IL-1 beta secretion in a concentration-dependent manner and had no effect on leukocyte IL-6 release.	Copper	90-96	interleukin 1 beta	Homo sapiens	17-35
2107032-2	1990	The secretion of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) was inhibited by copper under the same culture conditions, while zinc stimulated IL-1 beta secretion in a concentration-dependent manner and had no effect on leukocyte IL-6 release.	Copper	90-96	interleukin 1 beta	Homo sapiens	37-46
2107032-9	1990	This study suggests that the trace metals copper and zinc may play important and possibly distinct roles in regulating leukocyte secretion of TNF, IL-1 beta, and IL-6.	Copper	42-48	interleukin 1 beta	Homo sapiens	147-156
2138199-1	1990	Selective biotinylation of human interleukin-1 beta was achieved by reaction of an interleukin-1 beta mutant protein containing a surface-accessible cysteine with maleimido-biotin.	Cysteine	149-157	interleukin 1 beta	Homo sapiens	83-101
2138199-1	1990	Selective biotinylation of human interleukin-1 beta was achieved by reaction of an interleukin-1 beta mutant protein containing a surface-accessible cysteine with maleimido-biotin.	maleimido-biotin	163-179	interleukin 1 beta	Homo sapiens	33-51
2138199-1	1990	Selective biotinylation of human interleukin-1 beta was achieved by reaction of an interleukin-1 beta mutant protein containing a surface-accessible cysteine with maleimido-biotin.	maleimido-biotin	163-179	interleukin 1 beta	Homo sapiens	83-101
2138199-4	1990	Biotinylated interleukin-1 beta mutant protein bound to fluorescein-labelled avidin was used in flow cytometric analysis of interleukin-1 receptors.	Fluorescein	56-67	interleukin 1 beta	Homo sapiens	13-31
2107353-7	1990	However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2.	Prostaglandins	66-76	interleukin 1 beta	Homo sapiens	47-56
2140248-2	1990	The assay is based on a competition between unlabeled IL-1 and 125I-labeled mouse recombinant IL-1 alpha for binding to soluble IL-1 receptor prepared from mouse EL-4 cells.	Iodine-125	63-67	interleukin 1 beta	Homo sapiens	94-98
2107353-4	1990	Stimulation with interleukin-1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha) induced up to 18-fold (IL-1 beta) or up to fourfold (TNF alpha) increases of prostanoid release.	Prostaglandins	168-178	interleukin 1 beta	Homo sapiens	17-35
2107353-4	1990	Stimulation with interleukin-1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha) induced up to 18-fold (IL-1 beta) or up to fourfold (TNF alpha) increases of prostanoid release.	Prostaglandins	168-178	interleukin 1 beta	Homo sapiens	37-46
2107353-4	1990	Stimulation with interleukin-1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha) induced up to 18-fold (IL-1 beta) or up to fourfold (TNF alpha) increases of prostanoid release.	Prostaglandins	168-178	interleukin 1 beta	Homo sapiens	114-123
1693606-6	1990	Pharmacological modulators of LPS-induced IL-1 production were identified: glucocorticoids were inhibitors whereas retinoic acid and 1.25-dihydroxy-vitamin D3 had no effects and prostaglandin E2 and IBMX were weak inhibitors.	Tretinoin	115-128	interleukin 1 beta	Homo sapiens	42-46
1693606-6	1990	Pharmacological modulators of LPS-induced IL-1 production were identified: glucocorticoids were inhibitors whereas retinoic acid and 1.25-dihydroxy-vitamin D3 had no effects and prostaglandin E2 and IBMX were weak inhibitors.	Calcitriol	133-158	interleukin 1 beta	Homo sapiens	42-46
1693606-6	1990	Pharmacological modulators of LPS-induced IL-1 production were identified: glucocorticoids were inhibitors whereas retinoic acid and 1.25-dihydroxy-vitamin D3 had no effects and prostaglandin E2 and IBMX were weak inhibitors.	1-Methyl-3-isobutylxanthine	199-203	interleukin 1 beta	Homo sapiens	42-46
2107353-7	1990	However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2.	Prostaglandins	66-76	interleukin 1 beta	Homo sapiens	141-150
2107353-7	1990	However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2.	Dinoprostone	218-222	interleukin 1 beta	Homo sapiens	47-56
2107353-7	1990	However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2.	6-keto	236-242	interleukin 1 beta	Homo sapiens	47-56
2107353-7	1990	However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2.	prostaglandin F1	243-247	interleukin 1 beta	Homo sapiens	47-56
2107353-7	1990	However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2.	Dinoprost	267-271	interleukin 1 beta	Homo sapiens	47-56
2107353-8	1990	In the case of IL-1 beta + PDGF-BB the induction of PGE2 release was at least partly due to the synergistic induction of cyclooxygenase activity.	Dinoprostone	52-56	interleukin 1 beta	Homo sapiens	15-24
2298922-10	1990	These data demonstrate that pretreatment with IL-1 beta 24 h before the induction of colitis reduces inflammation by a mechanism that requires prostaglandin synthesis.	Prostaglandins	143-156	interleukin 1 beta	Homo sapiens	46-55
2404746-11	1990	Islets cultured with human recombinant IL-1 beta (25 units/ml) showed a strong inhibition of the insulin accumulation in the culture medium and of glucose-stimulated insulin release and a marked decrease in the islet DNA and insulin content.	Glucose	147-154	interleukin 1 beta	Homo sapiens	39-48
2155610-2	1990	Among the analogues tested, [Gly4]-, [Leu93]- and [1-148]-interleukin-1 beta increased the plasma adrenocorticotropic hormone level to almost that induced by authentic human interleukin-1 beta.	glycyl-glycyl-glycyl-glycine	29-33	interleukin 1 beta	Homo sapiens	174-192
2155610-3	1990	Modifications of the N-terminus of the authentic molecule, i.e., [7-153]- and [Des-Ala1, Asp4]-interleukin-1 beta, significantly reduced the hormone-releasing activity.	des-ala1	79-87	interleukin 1 beta	Homo sapiens	95-113
2105995-2	1990	Enhancement of IL-1 production by muramyl dipeptide-stimulated monocytes.	Dipeptides	42-51	interleukin 1 beta	Homo sapiens	15-19
2105995-3	1990	paf-Acether (paf) is a phospholipid mediator of inflammation released from monocytes along with IL-1.	Platelet Activating Factor	0-11	interleukin 1 beta	Homo sapiens	96-100
2105995-3	1990	paf-Acether (paf) is a phospholipid mediator of inflammation released from monocytes along with IL-1.	Platelet Activating Factor	0-3	interleukin 1 beta	Homo sapiens	96-100
2105995-4	1990	In this study, we have examined the role of paf on IL-1 production by human monocytes.	Platelet Activating Factor	44-47	interleukin 1 beta	Homo sapiens	51-55
2105995-5	1990	When paf from 1 nM to 5 microM, but not its precursor lyso paf, was added to monocytes in the presence of muramyl dipeptide (MDP) or LPS, a marked increase in IL-1 activity over the value with MDP alone was observed.	Platelet Activating Factor	5-8	interleukin 1 beta	Homo sapiens	159-163
2105995-5	1990	When paf from 1 nM to 5 microM, but not its precursor lyso paf, was added to monocytes in the presence of muramyl dipeptide (MDP) or LPS, a marked increase in IL-1 activity over the value with MDP alone was observed.	Acetylmuramyl-Alanyl-Isoglutamine	125-128	interleukin 1 beta	Homo sapiens	159-163
2105995-10	1990	When the paf receptor antagonist, L-652,731 was added to monocytes, it prevented the enhancement of IL-1 activity induced by exogenous paf.	l-652	34-39	interleukin 1 beta	Homo sapiens	100-104
2105995-10	1990	When the paf receptor antagonist, L-652,731 was added to monocytes, it prevented the enhancement of IL-1 activity induced by exogenous paf.	Platelet Activating Factor	9-12	interleukin 1 beta	Homo sapiens	100-104
2105995-14	1990	Nevertheless, exogenous paf in association with a second signal, modulates IL-1 production from human monocytes in a positive manner.	Platelet Activating Factor	24-27	interleukin 1 beta	Homo sapiens	75-79
2182048-1	1990	Interleukin-1 beta (IL-1 beta) and N-terminally extended Met-Glu-Ala-Glu-IL-1 beta (MEAE-IL-1 beta) were cloned and expressed in E. coli.	Glutamic Acid	61-64	interleukin 1 beta	Homo sapiens	73-82
2138997-5	1990	Moreover, both IL-1 beta and IL-1 alpha stimulated prostaglandin E2 production of cultured porcine thyroid cells, although the potency of IL-1 alpha was slightly greater than that of IL-1 beta.	Dinoprostone	51-67	interleukin 1 beta	Homo sapiens	15-24
1967907-6	1990	Involvement of PGE in the OVLT and POA in the ACTH response to intravenous IL-1 beta is also suggested.	Prostaglandins E	15-18	interleukin 1 beta	Homo sapiens	75-84
2137098-2	1990	One specific IL1 beta binding protein was observed, that when cross-linked to 125I-IL1 beta migrated to approximately 60 kDa on SDS-PAGE.	Sodium Dodecyl Sulfate	128-131	interleukin 1 beta	Homo sapiens	13-21
2137098-2	1990	One specific IL1 beta binding protein was observed, that when cross-linked to 125I-IL1 beta migrated to approximately 60 kDa on SDS-PAGE.	Sodium Dodecyl Sulfate	128-131	interleukin 1 beta	Homo sapiens	83-91
2193579-5	1990	Reduced production of cyclooxygenase products such as PGE2 also occurs in rats fed supplemental N-3 fatty acids, and this was associated with a decreased anorexic response to IL-1.	Fatty Acids, Omega-3	96-111	interleukin 1 beta	Homo sapiens	175-179
2182048-1	1990	Interleukin-1 beta (IL-1 beta) and N-terminally extended Met-Glu-Ala-Glu-IL-1 beta (MEAE-IL-1 beta) were cloned and expressed in E. coli.	Glutamic Acid	61-64	interleukin 1 beta	Homo sapiens	73-82
2182048-1	1990	Interleukin-1 beta (IL-1 beta) and N-terminally extended Met-Glu-Ala-Glu-IL-1 beta (MEAE-IL-1 beta) were cloned and expressed in E. coli.	Alanine	65-68	interleukin 1 beta	Homo sapiens	73-82
2182048-1	1990	Interleukin-1 beta (IL-1 beta) and N-terminally extended Met-Glu-Ala-Glu-IL-1 beta (MEAE-IL-1 beta) were cloned and expressed in E. coli.	Alanine	65-68	interleukin 1 beta	Homo sapiens	73-82
2224955-3	1990	The effect of IL-1 beta (0.1 to 10 ng/ml) on the time course of proliferation showed that values for DNA synthesis and cell numbers in RSC cultures were higher than in NRSC cultures.	rsc	135-138	interleukin 1 beta	Homo sapiens	14-23
2224955-5	1990	These results demonstrate that RSC, which are continuously stimulated by IL-1 beta produced in the rheumatoid pannus in vivo, have a higher capacity for proliferation than NRSC but are less responsive to IL-1 beta.	rsc	31-34	interleukin 1 beta	Homo sapiens	73-82
2224955-5	1990	These results demonstrate that RSC, which are continuously stimulated by IL-1 beta produced in the rheumatoid pannus in vivo, have a higher capacity for proliferation than NRSC but are less responsive to IL-1 beta.	rsc	31-34	interleukin 1 beta	Homo sapiens	204-213
2406177-1	1990	We recently reported a potentiating effect of recombinant human interleukin-1 beta on glucose-stimulated insulin release from the isolated perfused pancreas.	Glucose	86-93	interleukin 1 beta	Homo sapiens	64-82
2193579-6	1990	Therefore, one mechanism by which IL-1 induces anorexia appears to require cyclooxygenase metabolites, such as PGE2.	Dinoprostone	111-115	interleukin 1 beta	Homo sapiens	34-38
2193579-10	1990	The ability of N-3 fatty acids to reduce IL-1 synthesis appears to be via the lipoxygenase pathway.	Fatty Acids, Omega-3	15-30	interleukin 1 beta	Homo sapiens	41-45
2193579-11	1990	Therefore, N-3 fatty acids may be beneficial to patients with anorexia, since such supplements would decrease both the anorexic response to IL-1 via reduced cyclooxygenase metabolites and the production of IL-1, via altered lipoxygenase metabolites.	Fatty Acids, Omega-3	11-26	interleukin 1 beta	Homo sapiens	140-144
2193579-11	1990	Therefore, N-3 fatty acids may be beneficial to patients with anorexia, since such supplements would decrease both the anorexic response to IL-1 via reduced cyclooxygenase metabolites and the production of IL-1, via altered lipoxygenase metabolites.	Fatty Acids, Omega-3	11-26	interleukin 1 beta	Homo sapiens	206-236
2210874-8	1990	Contaminating endotoxin present in the tannin preparation accounted for the majority of IL-1 beta released from monocytes alone stimulated with tannin, but only 20% of the IL-1 beta released from tannin-stimulated monocyte-T-lymphocyte co-cultures.	Tannins	39-45	interleukin 1 beta	Homo sapiens	88-97
2210874-8	1990	Contaminating endotoxin present in the tannin preparation accounted for the majority of IL-1 beta released from monocytes alone stimulated with tannin, but only 20% of the IL-1 beta released from tannin-stimulated monocyte-T-lymphocyte co-cultures.	Tannins	144-150	interleukin 1 beta	Homo sapiens	88-97
2295789-2	1990	The concept of a membrane form of IL-1 arose from the observation that paraformaldehyde-treated macrophages display IL-1 bioactivity.	paraform	71-87	interleukin 1 beta	Homo sapiens	34-38
2117000-5	1990	IL-1 beta and TNF-alpha were found to be more efficient than TGF-beta in stimulating the production of GAG by the synovial cells.	Glycosaminoglycans	103-106	interleukin 1 beta	Homo sapiens	0-9
2170299-1	1990	N-succinimidyl[2,3-3H]propionate was used for the radiolabeling of the biologically active peptide fragment 163-171 of human interleukin-1 beta (VQGEESNDK).	n-succinimidyl[2,3-3h]propionate	0-32	interleukin 1 beta	Homo sapiens	125-143
2295789-0	1990	Detection of IL-1 alpha and IL-1 beta in the supernatants of paraformaldehyde-treated human monocytes.	paraform	61-77	interleukin 1 beta	Homo sapiens	28-37
2295789-2	1990	The concept of a membrane form of IL-1 arose from the observation that paraformaldehyde-treated macrophages display IL-1 bioactivity.	paraform	71-87	interleukin 1 beta	Homo sapiens	116-120
2136879-1	1990	Soluble polymerized human C3b and C3b bound to Sepharose induced the production of cell-associated IL-1 and the extracellular release of IL-1 activity from cultured human adherent monocytes.	Sepharose	47-56	interleukin 1 beta	Homo sapiens	99-103
2295789-7	1990	IL-1 activity can be detected in the supernatants of paraformaldehyde-treated human monocytes.	paraform	53-69	interleukin 1 beta	Homo sapiens	0-4
2136879-1	1990	Soluble polymerized human C3b and C3b bound to Sepharose induced the production of cell-associated IL-1 and the extracellular release of IL-1 activity from cultured human adherent monocytes.	Sepharose	47-56	interleukin 1 beta	Homo sapiens	137-141
2140145-3	1990	IL-1 can in its turn activate the lymphocytes to secretion of beta E. Here we demonstrate that the glucocorticoid analogue dexamethasone is capable of modulating CRF-induced beta E secretion by lymphocytes.	Dexamethasone	123-136	interleukin 1 beta	Homo sapiens	0-4
2140145-4	1990	It appeared that dexamethasone can inhibit secretion of lymphocyte-derived beta E. The mechanism by which dexamethasone exerts its inhibitory activity is by blocking CRF-induced production of IL-1, thereby preventing induction of beta E secretion by B cells.	Dexamethasone	17-30	interleukin 1 beta	Homo sapiens	192-196
2140145-4	1990	It appeared that dexamethasone can inhibit secretion of lymphocyte-derived beta E. The mechanism by which dexamethasone exerts its inhibitory activity is by blocking CRF-induced production of IL-1, thereby preventing induction of beta E secretion by B cells.	Dexamethasone	106-119	interleukin 1 beta	Homo sapiens	192-196
2250583-3	1990	Using the technique for site-specific mutagenesis, we tested whether the arginine residue at the 4th position in human IL-1 beta is essential for multiple biological activities.	Arginine	73-81	interleukin 1 beta	Homo sapiens	119-128
2301010-2	1990	Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene.	glucocorticosteroids	0-20	interleukin 1 beta	Homo sapiens	99-108
1983705-7	1990	The FTAF activity was inhibited about 50% by recombinant human interleukin-1 (IL-1) beta antiserum but not by recombinant human IL-1 alpha antiserum.	ftaf	4-8	interleukin 1 beta	Homo sapiens	78-88
2075374-2	1990	With relevance to rheumatoid arthritis (RA) IL-1 augments release of prostanoids, proteinases and oxygen metabolites and is a potent inducer of bone and cartilage resorption.	Prostaglandins	69-80	interleukin 1 beta	Homo sapiens	44-48
2075374-2	1990	With relevance to rheumatoid arthritis (RA) IL-1 augments release of prostanoids, proteinases and oxygen metabolites and is a potent inducer of bone and cartilage resorption.	Oxygen	98-104	interleukin 1 beta	Homo sapiens	44-48
2091257-9	1990	Children with Haemophilus influenzae, type b meningitis treated with dexamethasone had significantly reduced levels of CSF IL-1 beta compared to placebo-treated controls.	Dexamethasone	69-82	interleukin 1 beta	Homo sapiens	123-132
2301010-3	1990	Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA.	glucocorticosteroids	0-20	interleukin 1 beta	Homo sapiens	58-62
24440992-10	2014	In vitro, HU-308, a selective CB2R agonist, inhibited IL-1beta-induced proliferation of RA-FLS as well as IL-1beta-induced production of MMP-3, MMP-13 and IL-6 in RA-FLS in a dose-dependent manner.	HU 308	10-16	interleukin 1 beta	Homo sapiens	54-62
33774155-6	2021	We recently demonstrated that AAT isolated from the blood of healthy persons efficiently inhibits the ATP-induced release of interleukin-1beta by human monocytes.	Adenosine Triphosphate	102-105	interleukin 1 beta	Homo sapiens	125-142
33941028-7	2021	In addition, the IL1B rs1143634 C/T polymorphism was related with the levels of blood lipids including low-density lipoprotein (LDL), and total cholesterol (TC).	Cholesterol	144-155	interleukin 1 beta	Homo sapiens	17-21
33941028-7	2021	In addition, the IL1B rs1143634 C/T polymorphism was related with the levels of blood lipids including low-density lipoprotein (LDL), and total cholesterol (TC).	Technetium	157-159	interleukin 1 beta	Homo sapiens	17-21
33941028-8	2021	This study uncovers that the IL1B rs1143634 C/T polymorphism may associate with the risk and blood lipid levels of MI in an Eastern Chinese Han population.Abbreviations: MI: myocardial infarction; IL-1: Interleukin-1; SNP: single nucleotide polymorphism; BMI: Body Mass Index; HDL: high-density lipoprotein; TC: total cholesterol; TG: triglyceride; LDL: low-density lipoprotein; PCR: polymerase chain reaction; 95% CI: 95% confidence interval; OR: odds ratio.	Technetium	308-310	interleukin 1 beta	Homo sapiens	29-33
33941028-8	2021	This study uncovers that the IL1B rs1143634 C/T polymorphism may associate with the risk and blood lipid levels of MI in an Eastern Chinese Han population.Abbreviations: MI: myocardial infarction; IL-1: Interleukin-1; SNP: single nucleotide polymorphism; BMI: Body Mass Index; HDL: high-density lipoprotein; TC: total cholesterol; TG: triglyceride; LDL: low-density lipoprotein; PCR: polymerase chain reaction; 95% CI: 95% confidence interval; OR: odds ratio.	Cholesterol	318-329	interleukin 1 beta	Homo sapiens	29-33
33941028-8	2021	This study uncovers that the IL1B rs1143634 C/T polymorphism may associate with the risk and blood lipid levels of MI in an Eastern Chinese Han population.Abbreviations: MI: myocardial infarction; IL-1: Interleukin-1; SNP: single nucleotide polymorphism; BMI: Body Mass Index; HDL: high-density lipoprotein; TC: total cholesterol; TG: triglyceride; LDL: low-density lipoprotein; PCR: polymerase chain reaction; 95% CI: 95% confidence interval; OR: odds ratio.	Thioguanine	331-333	interleukin 1 beta	Homo sapiens	29-33
33941028-8	2021	This study uncovers that the IL1B rs1143634 C/T polymorphism may associate with the risk and blood lipid levels of MI in an Eastern Chinese Han population.Abbreviations: MI: myocardial infarction; IL-1: Interleukin-1; SNP: single nucleotide polymorphism; BMI: Body Mass Index; HDL: high-density lipoprotein; TC: total cholesterol; TG: triglyceride; LDL: low-density lipoprotein; PCR: polymerase chain reaction; 95% CI: 95% confidence interval; OR: odds ratio.	Triglycerides	335-347	interleukin 1 beta	Homo sapiens	29-33
33941087-13	2021	AAE exhibited increased IL-1B and TNF-alpha expression compared with NAE (p < 0.05).	acetoacetic acid	0-3	interleukin 1 beta	Homo sapiens	24-29
33941087-15	2021	IL-1B and TNF-alpha could be useful to differentially diagnose AAE and NAE in the non-erosive phenotype using endoscopic biopsies.	acetoacetic acid	63-66	interleukin 1 beta	Homo sapiens	0-5
33941087-15	2021	IL-1B and TNF-alpha could be useful to differentially diagnose AAE and NAE in the non-erosive phenotype using endoscopic biopsies.	N-lauroylethanolamine	71-74	interleukin 1 beta	Homo sapiens	0-5
33798839-7	2021	Metformin exposure was also associated with decreased levels of the inflammatory cytokines TNFalpha, IL-1a, IL-1b and IL-6 in serum, placenta and omental tissue taken from pregnant women.	Metformin	0-9	interleukin 1 beta	Homo sapiens	108-113
31412862-6	2019	BBR also caused a marked reduction in the secretion of proinflammatory cytokines, Interleukin-1alpha (IL-1alpha), Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Berberine	0-3	interleukin 1 beta	Homo sapiens	114-131
26640530-13	2015	In the DEX group compared with the control group, IL-1beta, IL-6 and CRP levels were markedly decreased at 6 h and 1 day after surgery (P&lt;0.01).	Dextromethorphan	7-10	interleukin 1 beta	Homo sapiens	50-58
26640530-14	2015	Concentrations of IL-1beta, IL-6 and CRP were significantly higher in patients who developed POCD on day 1 following surgery than in the patients who did not develop POCD (P&lt;0.05).	pocd	93-97	interleukin 1 beta	Homo sapiens	18-26
25635622-9	2015	Cotreatment with RU486 (mifepristone) attenuated the inhibition of IL-1beta and leukemia inhibitory factor secretion.	Mifepristone	17-22	interleukin 1 beta	Homo sapiens	67-75
25635622-9	2015	Cotreatment with RU486 (mifepristone) attenuated the inhibition of IL-1beta and leukemia inhibitory factor secretion.	Mifepristone	24-36	interleukin 1 beta	Homo sapiens	67-75
25781159-8	2015	Neutralization of pro-inflammatory cytokines, especially interleukin 1beta with the IL-1 receptor antagonist (IL-1Ra) and/or IL-1beta antibodies might cause the extinction of the inflammatory process of pancreatic islets, and consequently normalize concentration of glucose in blood and decrease the insulin resistance.	Glucose	266-273	interleukin 1 beta	Homo sapiens	57-74
25781159-8	2015	Neutralization of pro-inflammatory cytokines, especially interleukin 1beta with the IL-1 receptor antagonist (IL-1Ra) and/or IL-1beta antibodies might cause the extinction of the inflammatory process of pancreatic islets, and consequently normalize concentration of glucose in blood and decrease the insulin resistance.	Glucose	266-273	interleukin 1 beta	Homo sapiens	125-133
31881266-0	2020	Title: Manganese is associated with increased plasma interleukin-1beta during pregnancy, within a mixtures analysis framework of urinary trace metals.	Manganese	7-16	interleukin 1 beta	Homo sapiens	53-70
31881266-4	2020	Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1beta (IL-1beta).	Manganese	17-26	interleukin 1 beta	Homo sapiens	95-112
31881266-4	2020	Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1beta (IL-1beta).	Manganese	17-26	interleukin 1 beta	Homo sapiens	114-122
31881266-4	2020	Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1beta (IL-1beta).	Nickel	28-34	interleukin 1 beta	Homo sapiens	95-112
31881266-4	2020	Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1beta (IL-1beta).	Nickel	28-34	interleukin 1 beta	Homo sapiens	114-122
31881266-5	2020	Elastic net and Bayesian kernel machine regression identified manganese as the dominant trace metal in association with IL-1beta.	Manganese	62-71	interleukin 1 beta	Homo sapiens	120-128
31881266-6	2020	An interquartile range difference in manganese (0.6 mug/L) was associated with a 29% increase in IL-1beta (95% CI: 12.4 - 48.2).	Manganese	37-46	interleukin 1 beta	Homo sapiens	97-105
29185963-9	2018	The peak calcium concentration evoked by 10 muM histamine was increased by IL-1beta and this increase was reversed under NMRT treatment.	Calcium	9-16	interleukin 1 beta	Homo sapiens	75-83
29185963-9	2018	The peak calcium concentration evoked by 10 muM histamine was increased by IL-1beta and this increase was reversed under NMRT treatment.	Histamine	48-57	interleukin 1 beta	Homo sapiens	75-83
29185963-11	2018	The IL-1beta-induced decline in intracellular ATP and the elevated NF-kappaB activity was reversed under NMRT stimulation.	Adenosine Triphosphate	46-49	interleukin 1 beta	Homo sapiens	4-12
26146191-5	2015	A significant (p &lt; 0.01) increase in pro-inflammatory cytokines (TNF-alpha and IL-1beta) and reactive oxygen species (ROS) was observed with a concomitant concentration dependent (0.5, 1, 5, 10, 15 and 20 mug/mL) decrease in the glutathione (GSH) levels as compared to control.	Glutathione	232-243	interleukin 1 beta	Homo sapiens	82-90
26146191-5	2015	A significant (p &lt; 0.01) increase in pro-inflammatory cytokines (TNF-alpha and IL-1beta) and reactive oxygen species (ROS) was observed with a concomitant concentration dependent (0.5, 1, 5, 10, 15 and 20 mug/mL) decrease in the glutathione (GSH) levels as compared to control.	Glutathione	245-248	interleukin 1 beta	Homo sapiens	82-90
25728492-5	2015	We also found that the level of adenosine triphosphate (ATP) in SF and ST was significantly increased in RA patients and that the level of IL-1beta in supernatants from Cyr61-activated FLS increased significantly when we added exogenous ATP to the culture.	Adenosine Triphosphate	237-240	interleukin 1 beta	Homo sapiens	139-147
25728492-6	2015	Mechanistically, Cyr61 induced proIL-1beta production in FLS via the AKT-dependent NF-kappaB signaling pathway, and ATP caused Cyr61-induced proIL-1beta to generate IL-1beta in a caspase-1-dependent manner.	Adenosine Triphosphate	116-119	interleukin 1 beta	Homo sapiens	141-152
24440992-10	2014	In vitro, HU-308, a selective CB2R agonist, inhibited IL-1beta-induced proliferation of RA-FLS as well as IL-1beta-induced production of MMP-3, MMP-13 and IL-6 in RA-FLS in a dose-dependent manner.	HU 308	10-16	interleukin 1 beta	Homo sapiens	106-114
20218345-8	2010	CONCLUSION: LX inhibits TLR-mediated production of both proinflammatory (IL-1, IL-6, IL-8, IL-12, TNFalpha) and anti-inflammatory (IL-10) cytokinesby PBMC of healthy subjects in vitro.	lx	12-14	interleukin 1 beta	Homo sapiens	73-77
9227316-0	1997	Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-alpha, IL-1 beta IL-10 by human leucocytes.	lisofylline	10-21	interleukin 1 beta	Homo sapiens	94-109
18321735-0	2008	Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.	diacerein	75-84	interleukin 1 beta	Homo sapiens	88-96
18321735-3	2008	METHODS: Interleukin-1beta (IL-1beta)-stimulated C-28/I2 cells were cultured in the presence of GlcN, curcumin, and diacerein prior to the evaluation of parameters such as viability, morphology and proliferation.	Glucosamine	96-100	interleukin 1 beta	Homo sapiens	9-26
18321735-3	2008	METHODS: Interleukin-1beta (IL-1beta)-stimulated C-28/I2 cells were cultured in the presence of GlcN, curcumin, and diacerein prior to the evaluation of parameters such as viability, morphology and proliferation.	Glucosamine	96-100	interleukin 1 beta	Homo sapiens	28-36
18321735-3	2008	METHODS: Interleukin-1beta (IL-1beta)-stimulated C-28/I2 cells were cultured in the presence of GlcN, curcumin, and diacerein prior to the evaluation of parameters such as viability, morphology and proliferation.	Curcumin	102-110	interleukin 1 beta	Homo sapiens	9-26
18321735-6	2008	Moreover, the IL-1beta-mediated shift in gene expression pattern was antagonized by GlcN and diacerein.	Glucosamine	84-88	interleukin 1 beta	Homo sapiens	14-22
18321735-6	2008	Moreover, the IL-1beta-mediated shift in gene expression pattern was antagonized by GlcN and diacerein.	diacerein	93-102	interleukin 1 beta	Homo sapiens	14-22
18684938-0	2008	Ethanol enhances neutrophil membrane tether growth and slows rolling on P-selectin but reduces capture from flow and firm arrest on IL-1-treated endothelium.	Ethanol	0-7	interleukin 1 beta	Homo sapiens	132-136
18684938-7	2008	On IL-1-stimulated endothelium, rolling velocity was unchanged by ethanol treatment, but the fraction of cells converting to firm arrest was reduced from 35% to 24% with ethanol.	Ethanol	170-177	interleukin 1 beta	Homo sapiens	3-7
14561211-13	2002	It has been shown that macrolides inhibit the production of IL-8 and IL-1beta and the expression of ICAM-1, suggesting that macrolides block the aforementioned dual positive feedback system of neutrophil recruitment and thereby exert their clinical efficacy in the treatment of chronic sinusitis.	Macrolides	23-33	interleukin 1 beta	Homo sapiens	69-77
14561211-13	2002	It has been shown that macrolides inhibit the production of IL-8 and IL-1beta and the expression of ICAM-1, suggesting that macrolides block the aforementioned dual positive feedback system of neutrophil recruitment and thereby exert their clinical efficacy in the treatment of chronic sinusitis.	Macrolides	124-134	interleukin 1 beta	Homo sapiens	69-77
9269788-7	1997	Compared with vehicle control, pretreatment with SDZ MRL 953 markedly reduced the release of TNF-alpha, IL-1beta, IL-8, IL-6, and G-CSF, but augmented the increase in granulocyte counts to endotoxin.	Sulfadiazine	49-52	interleukin 1 beta	Homo sapiens	104-112
9227316-0	1997	Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-alpha, IL-1 beta IL-10 by human leucocytes.	Pentoxifylline	26-40	interleukin 1 beta	Homo sapiens	94-109
7880975-2	1994	After one hour incubation with interleukin-1 beta (IL-1 beta), the uptake of alpha-(methylamino) isobutyric acid (MeAIB) by human osteoarthritic synovial cells appeared significantly increased.	2-(methylamino)isobutyric acid	77-112	interleukin 1 beta	Homo sapiens	31-49
7880975-2	1994	After one hour incubation with interleukin-1 beta (IL-1 beta), the uptake of alpha-(methylamino) isobutyric acid (MeAIB) by human osteoarthritic synovial cells appeared significantly increased.	2-(methylamino)isobutyric acid	77-112	interleukin 1 beta	Homo sapiens	51-60
7880975-2	1994	After one hour incubation with interleukin-1 beta (IL-1 beta), the uptake of alpha-(methylamino) isobutyric acid (MeAIB) by human osteoarthritic synovial cells appeared significantly increased.	2-(methylamino)isobutyric acid	114-119	interleukin 1 beta	Homo sapiens	31-49
7880975-2	1994	After one hour incubation with interleukin-1 beta (IL-1 beta), the uptake of alpha-(methylamino) isobutyric acid (MeAIB) by human osteoarthritic synovial cells appeared significantly increased.	2-(methylamino)isobutyric acid	114-119	interleukin 1 beta	Homo sapiens	51-60
7880975-5	1994	Finally, intracellular cAMP concentration measurements, the use of a phorbol ester, protein kinase inhibitors and forskolin+3-isobutyl-1-methylxantine (IBMX) provided evidence that a cAMP-dependent protein kinase is associated with interleukin-1 beta-mediated alpha-(methylamino) isobutyric acid uptake.	3-isobutyl-1-methylxantine	124-150	interleukin 1 beta	Homo sapiens	232-250
7880975-5	1994	Finally, intracellular cAMP concentration measurements, the use of a phorbol ester, protein kinase inhibitors and forskolin+3-isobutyl-1-methylxantine (IBMX) provided evidence that a cAMP-dependent protein kinase is associated with interleukin-1 beta-mediated alpha-(methylamino) isobutyric acid uptake.	1-Methyl-3-isobutylxanthine	152-156	interleukin 1 beta	Homo sapiens	232-250
7880975-5	1994	Finally, intracellular cAMP concentration measurements, the use of a phorbol ester, protein kinase inhibitors and forskolin+3-isobutyl-1-methylxantine (IBMX) provided evidence that a cAMP-dependent protein kinase is associated with interleukin-1 beta-mediated alpha-(methylamino) isobutyric acid uptake.	Cyclic AMP	183-187	interleukin 1 beta	Homo sapiens	232-250
7880977-3	1994	In situ hybridizations, using anti-sense 35S dUTP-labeled IL-1 beta, IL-6 and TNF-alpha riboprobes, were performed on cryostat liver sections; the sense probes were used as negative controls.	deoxyuridine triphosphate	45-49	interleukin 1 beta	Homo sapiens	58-67
34881566-9	2022	Furthermore, cell experiments demonstrated that such glyco-nanostructures can further facilitate the functions of a model drug of the pyridone agent to reduce the expression of monocyte chemotactic protein-1 (MCP-1) and interleukin -1beta (IL-1beta) in the primary peritoneal macrophages via encapsulating drugs.	Pyridones	134-142	interleukin 1 beta	Homo sapiens	220-238
34922939-9	2022	The induction of ROS affected the level of proinflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	Reactive Oxygen Species	17-20	interleukin 1 beta	Homo sapiens	69-86
34978772-5	2021	The anti-inflammatory effects of miR-181a-5p were evaluated by examining pro-inflammatory cytokines (interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha (TNF-alpha)) in the culture of RPMI-2650 cells stimulated by ovalbumin, using quantitative real-time reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay.	mir-181a-5p	33-44	interleukin 1 beta	Homo sapiens	100-123
34856207-12	2022	CPFX treatment (i) increased expression of CASP-3, CASP-9, and BCL2-L13, (ii) elevated the basal oxygen consumption rate, and (iii) lowered the mtDNA copy numbers and expression levels of TGF-B2, IL-6 and IL-1B compared to vehicle-control cells.	Ciprofloxacin	0-4	interleukin 1 beta	Homo sapiens	205-210
34916479-8	2021	NLRP3 was identified as being significantly activated by 5-FU, but galangin treatment reversed the effect and inhibited NLRP3 expression, which was accompanied by downregulated interleukin-1b levels.	Fluorouracil	57-61	interleukin 1 beta	Homo sapiens	177-191
34986125-9	2021	Finally, the binding modes of EGFR, IL1B, NOS3 and TP53 with quercetin were visualized.	Quercetin	61-70	interleukin 1 beta	Homo sapiens	36-40
34986125-10	2021	DISCUSSION AND CONCLUSION: Quercetin of Baiying Qinghou decoction showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway.	Quercetin	27-36	interleukin 1 beta	Homo sapiens	169-173
34916479-8	2021	NLRP3 was identified as being significantly activated by 5-FU, but galangin treatment reversed the effect and inhibited NLRP3 expression, which was accompanied by downregulated interleukin-1b levels.	galangin	67-75	interleukin 1 beta	Homo sapiens	177-191
34180760-15	2021	This study provides a theoretical basis for elucidating the mechanism of mepivacaine-induced nerve cell damage, and overexpressed miR-183-5p likely become a novel strategy to combat mepivacaine-induced nerve damage.Abbreviations:miRNA: Micro RNA; PDCD4: Programmed Cell Death 4; MDA: Malondialdehyde; SOD: Superoxide Dismutase; ROS: Reactive Oxygen Species; WT: Wild Type; Mut: Mutant; UTR: Untranslated Region; IL-6: Interleukin-6; IL-1beta: Interleukin-1beta; TNF-alpha: Tumor Necrosis Factor-alpha; IL-8: Interleukin-8; COX-2: Cyclooxygenase-2; iNOS: inducible NOS; MEP: Mepivacaine.	mir-183-5p	130-140	interleukin 1 beta	Homo sapiens	443-460
34904269-3	2022	This study was conducted to evaluate the expression of selected cytokine (IL1B, IL2, IL6, IL10, TNF, TGFB1, IFNG) and Toll-like receptor (TLR2) genes in lymphocytes isolated from whole human blood infected with S. aureus Newman strain treated with TA.	anethole	248-250	interleukin 1 beta	Homo sapiens	74-78
34904269-6	2022	The lymphocytes isolated from the blood infected with TA-treated staphylococcal cells demonstrated significantly greater IL10, IL1B, IL6, TNF and TLR2 expression.	anethole	54-56	interleukin 1 beta	Homo sapiens	127-131
34956864-6	2021	Results: In pre-treatment biopsies, TREM1 and known TREM-1 inducible cytokines (IL1B, IL8) were discovered by a statistical ranking procedure as top genes for which high expression was associated with reduced response to NAC, but only in the context of immunologically "hot" tumors otherwise associated with a high NAC response rate.	nac	221-224	interleukin 1 beta	Homo sapiens	80-84
34975889-3	2021	In our analysis of the mechanism of action, Antcin K inhibited the expression of three cytokines (tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and IL-8) in human RASFs; cytokines that are crucial to RA synovial inflammation.	antcin K	44-52	interleukin 1 beta	Homo sapiens	139-157
34427537-0	2021	The protective effects of naproxen against interleukin-1beta (IL-1beta)- induced damage in human umbilical vein endothelial cells (HUVECs).	Naproxen	26-34	interleukin 1 beta	Homo sapiens	43-60
34338149-7	2021	Furthermore, the activated NLRP3 inflammasome and the excessive production of interleukin 18 (IL-18) and interleukin 1beta (IL-1beta) in HrGECs induced by incubation with HG were pronouncedly reversed by the introduction of Omarigliptin, accompanied by the activation of the AMPK/mTOR signaling pathway.	2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)-2,6-dihydropyrrolo(3,4-c)pyrazol-5(4H)-yl)tetrahydro-2H-pyran-3-amine	224-236	interleukin 1 beta	Homo sapiens	105-122
34288819-0	2021	Anagliptin prevented interleukin 1beta (IL-1beta)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1).	anagliptin	0-10	interleukin 1 beta	Homo sapiens	21-38
34414854-10	2021	Transfection of p-LUCAT1 significantly reversed the decreased SOD levels, the increased MDA and ROS content, and the elevated tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1beta) in H2O2-stimulated cells (P < 0.001).	Hydrogen Peroxide	226-230	interleukin 1 beta	Homo sapiens	193-211
34709541-8	2021	CONCLUSION: Glutamine supplementation in COVID-19 patients with respiratory infection significantly reduces serum levels of interleukin-1 beta, hs-CRP, and tumor necrosis factor-alpha and significantly increases appetite, so glutamine supplementation may be useful for COVID-19 patients in the hospital.	Glutamine	12-21	interleukin 1 beta	Homo sapiens	124-142
34496682-5	2021	RESULTS: High cobalt chloride exposure mediated significant increase in caspase-1 activity, cytokine levels, and IL1B and NLRP3 expression with a corresponding regulatory decrease for CASP1 and PYCARD expression.	cobaltous chloride	14-29	interleukin 1 beta	Homo sapiens	113-117
34374483-10	2021	Co-treatment of macrophages with HGF and PGE2 reduced pro-IL-1beta expression level and active IL-1beta secretion.	Dinoprostone	41-45	interleukin 1 beta	Homo sapiens	54-66
34717170-3	2021	This open-label, prospective, observational study evaluated the effect of valproate and add-on levetiracetam on serum levels of C-C motif ligand 2 (CCL2) and Interleukin-1 beta (IL-1beta) in pediatric patients with epilepsy.	Valproic Acid	74-83	interleukin 1 beta	Homo sapiens	158-176
34717170-3	2021	This open-label, prospective, observational study evaluated the effect of valproate and add-on levetiracetam on serum levels of C-C motif ligand 2 (CCL2) and Interleukin-1 beta (IL-1beta) in pediatric patients with epilepsy.	Levetiracetam	95-108	interleukin 1 beta	Homo sapiens	158-176
34506261-8	2021	Argon increased the proliferation of cardiomyocytes induced by OGD, decreased the release of LDH in cell culture medium, increased miR-21 expression in cells, decreased the expression of miR-21 target proteins PDCD4 and PTEN, decreased the levels of inflammatory factors (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8)) and oxidative stress factors (ROS and MDA), increased the SOD content, and decreased the cell apoptosis rate.	Argon	0-5	interleukin 1 beta	Homo sapiens	272-289
34601327-0	2021	In-vitro immunomodulatory effects of nicotine on Nitric Oxide, interleukin 1beta and interleukin 37 production in human peripheral blood mononuclear cells (PBMC) from patients with Behcet disease.	Nicotine	37-45	interleukin 1 beta	Homo sapiens	63-80
34601327-2	2021	In our current study we sought to evaluate the in-vitro modulatory effect of nicotine, the principal alkaloid of tobacco, on nitric oxide (NO), interleukin 1beta (IL-1beta) and interleukin 37 (IL-37) production during Behcet"s disease.	Nicotine	77-85	interleukin 1 beta	Homo sapiens	144-161
34799616-11	2021	In the treatment of myocardial infarction, we have obtained key targets of Yixinyin, which are ALDH2, C5AR1, FOS, IL1B, TLR2, TXNRD1.	yixinyin	75-83	interleukin 1 beta	Homo sapiens	114-118
34555775-6	2021	Furthermore, lavandolide D inhibited NOD-, LRR- and pyrin domain-containing protein 3 inflammasome-mediated interleukin-1beta production through activating autophagy.	lavandolide d	13-26	interleukin 1 beta	Homo sapiens	108-125
34643000-5	2021	CBD caused a parallel inhibition of interleukin 1 beta (IL-1beta), IL-6, tumor necrosis factor alpha (TNF-alpha), and IL-18 by enzyme-linked immunosorbent assay (ELISA) assay.	Cannabidiol	0-3	interleukin 1 beta	Homo sapiens	36-54
34872043-5	2021	1,25(OH)2VD3 suppressed nigericin-induced interleukin-1beta (IL-1beta) secretion and caspase-1 activation in human primary keratinocytes.	Nigericin	24-33	interleukin 1 beta	Homo sapiens	42-59
34846578-4	2022	Primary human OA chondrocytes in vitro respond to carbohydrate-inhibitable Gal-4 binding with the upregulation of pro-degradative/-inflammatory proteins such as interleukin-1beta (IL-1beta) and matrix metalloproteinase-13 (MMP-13), as documented by RT-qPCR-based mRNA profiling and transcriptome data processing.	Carbohydrates	50-62	interleukin 1 beta	Homo sapiens	161-178
34433098-9	2021	After K-3-rh intervention, the expression of Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta(IL-1beta), and nitric oxide(NO) in microglia were reduced contrast with those in the virus group, and the expression of interleukin-10(IL-10) did not change.	kaempferol 3-O-rhamnoside	6-12	interleukin 1 beta	Homo sapiens	86-104
34827151-7	2021	The serum of traditional beer consumers did not exhibit the same capacity as the serum of alcohol-free beer consumers to reduce gene expression of pro-inflammatory interleukins; however, serum from traditional beer consumers showed a regulatory effect at the protein level by significantly decreasing the intracellular protein levels of pro-IL-1beta in primed macrophages and preventing cleaved-IL-1beta protein release.	Alcohols	90-97	interleukin 1 beta	Homo sapiens	337-349
34260712-0	2021	Cabergoline Stimulates Human Endometrial Stromal Cell Decidualization and Reverses Effects of Interleukin-1beta in vitro.	Cabergoline	0-11	interleukin 1 beta	Homo sapiens	94-111
34867921-1	2021	Nucleotide-binding domain and leucine-rich repeat-containing protein 3 (NLRP3) inflammasome-mediated interleukin-1 beta (IL-1beta) production is one of the crucial responses in innate immunity upon infection with viruses including influenza A virus (IAV) and is modulated by both viral and host cellular proteins.	Leucine	30-37	interleukin 1 beta	Homo sapiens	101-119
34836309-0	2021	Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1.	Vitamin D	20-29	interleukin 1 beta	Homo sapiens	142-146
34836309-9	2021	The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1.	25ohd	59-64	interleukin 1 beta	Homo sapiens	148-152
34836309-9	2021	The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1.	Vitamin D	84-93	interleukin 1 beta	Homo sapiens	148-152
34767572-6	2021	RESULTS: PKD activation/auto-phosphorylation always preceded cleavage of caspase-1 and gasdermin D, and treatment with the PKD inhibitor CRT0066101 could block NLRP3 inflammasome assembly and interleukin-1beta production.	CRT 0066101	137-147	interleukin 1 beta	Homo sapiens	192-209
34771080-6	2021	It has been shown that, in the presence of homocysteine, the secretion of IL-1, IL-6 and RANTES by PBMNCs was increased, whereas IL-10 concentration was significantly lower than that of the supernatant derived from a mitogen-stimulated cell culture without homocysteine.	Homocysteine	43-55	interleukin 1 beta	Homo sapiens	74-78
34146182-0	2021	Higenamine mitigates interleukin-1beta-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling.	higenamine	0-10	interleukin 1 beta	Homo sapiens	21-38
34310083-11	2021	Azithromycin concentration was positively correlated with IL-8 (r = 0.38, p = 0.03), IL1a (r = 0.39, p = 0.03), and IL-1b (r = 0.36, p = 0.04) in amniotic fluid.	Azithromycin	0-12	interleukin 1 beta	Homo sapiens	116-121
34509368-3	2021	Results of enzyme-linked immunosorbent assay (ELISA) showed that WEKPPVSH significantly mitigated the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) (P < 0.01).	wekppvsh	65-73	interleukin 1 beta	Homo sapiens	156-173
34675809-7	2021	Notably, the increased expression levels of TLR4, NLRP3, interleukin 1beta, and interleukin 18 proteins and the elevated activities of caspase-1 and lactic dehydrogenase in in vivo and in vitro disease models were markedly reversed by the treatment with BHGZD.	bhgzd	254-259	interleukin 1 beta	Homo sapiens	57-74
34371477-0	2021	Polymorphisms in the IL1-b gene are associated with increased Glu and Glx levels in treatment-resistant depression.	Glutamic Acid	62-65	interleukin 1 beta	Homo sapiens	21-26
34378862-0	2021	A single application of chlorhexidine gel reduces gingival inflammation and interleukin 1-beta following one-stage implant placement: A randomized controlled study.	Chlorhexidine	24-37	interleukin 1 beta	Homo sapiens	76-94
34671275-13	2021	CXCL8, IL6, and IL1B were increased by the MRTF-SRF inhibitor CCG-1423 and by MRTF-A silencing in hCASMCs, but depolymerization of actin, known to inhibit MRTF activity, had no stimulatory effect, an exception being IL1B.	CCG 1423	62-70	interleukin 1 beta	Homo sapiens	16-20
34469050-6	2021	Luminex assay of EAT-secretome identified increased release of various proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interferon-alpha 2 (IFNA2), interleukin 1 beta (IL1B), interleukin 5 (IL5), interleukin 13 (IL13), and CCL5, among others, in response to high glucose, high palmitate, and lipopolysaccharide.	Glucose	292-299	interleukin 1 beta	Homo sapiens	177-195
34469050-6	2021	Luminex assay of EAT-secretome identified increased release of various proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interferon-alpha 2 (IFNA2), interleukin 1 beta (IL1B), interleukin 5 (IL5), interleukin 13 (IL13), and CCL5, among others, in response to high glucose, high palmitate, and lipopolysaccharide.	Glucose	292-299	interleukin 1 beta	Homo sapiens	197-201
34447474-0	2021	Herbal melanin induces interleukin-1beta secretion and production by human THP-1 monocytes via Toll-like receptor 2 and p38 MAPK activation.	Melanins	7-14	interleukin 1 beta	Homo sapiens	23-40
34566641-8	2021	Plasma kallikrein treatment significantly increased the proliferation of CCl4-induced HepG2 cells and induced a significant increase in the gene expression of the thrombin receptor (protease activated receptor-1), interleukin 1 beta, and lectin-galactose binding soluble 3 (galectin-3) (p < 0.05, n = 4).	Carbon Tetrachloride	73-77	interleukin 1 beta	Homo sapiens	214-232
34447474-3	2021	However, the potential effect of HM on the production of interleukin-1beta (IL-1beta), the main immunoregulatory cytokine secreted by activated monocytes, has not been reported.	His-Met	33-35	interleukin 1 beta	Homo sapiens	57-74
34514543-10	2021	Conversely, alpha7 nAChR-specific agonist GTS-21 diminished the release of interleukin-1beta (IL-1beta), IL-6, IL-8, and tumor necrosis factor-alpha (TNFalpha) in SH-SY5Y cells under inflammatory conditions.	3-(2,4-dimethoxybenzylidene)anabaseine	42-48	interleukin 1 beta	Homo sapiens	75-92
34169408-12	2021	IL-1B had the diagnostic power of 0.72 in distinguishing between ADP cases and controls.	Adenosine Diphosphate	65-68	interleukin 1 beta	Homo sapiens	0-5
34584119-8	2021	Moreover, metformin also triggered mRNA expression of the proinflammatory cytokines IL1B, CXCL8 and growth factor GDF15 in human uroepithelial cells.	Metformin	10-19	interleukin 1 beta	Homo sapiens	84-88
34630388-6	2021	In the serum and jejunum, supplementation with more than 600 mg/kg GML reduced (P < 0.05) interleukin-1beta, tumor necrosis factor-alpha, and malondialdehyde levels and increased (P < 0.05) the levels of immunoglobulin G, jejunal mucin 2, total antioxidant capacity, and total superoxide dismutase.	monolaurin	67-70	interleukin 1 beta	Homo sapiens	90-107
34630388-7	2021	GML down-regulate (P < 0.05) jejunal interleukin-1beta and interferon-gamma expression and increased (P < 0.05) the mRNA level of zonula occludens 1 and occludin.	monolaurin	0-3	interleukin 1 beta	Homo sapiens	37-54
34533033-9	2021	Pathway analysis suggested gene expression changes, driven by a network of inflammatory cytokines centered on IL-1beta (interleukin 1beta), lead to repression of reno-protective eNOS (endothelial nitric oxide synthase) signaling during ADHF development, and following recovery, activation of glomerulosclerosis and reno-protective pathways and repression of proinflammatory/fibrotic pathways.	adhf	236-240	interleukin 1 beta	Homo sapiens	120-137
34214916-9	2021	What"s more, DMEP activated the Nuclear factor-kappaB (NF-kappaB) pathway and levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) were significantly upregulated, causing an inflammatory response.	dimethoxyethyl phthalate	13-17	interleukin 1 beta	Homo sapiens	129-146
34463643-7	2021	Glucose-stimulated insulin secretion and production of inflammatory cytokines (TNFa, IL1b and IFNg) were measured by ELISA.	Glucose	0-7	interleukin 1 beta	Homo sapiens	85-89
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	interleukin 1 beta	Homo sapiens	267-271
34497300-0	2021	Monocyte-derived and M1 macrophages from ankylosing spondylitis patients released higher TNF-alpha and expressed more IL1B in response to BzATP than macrophages from healthy subjects.	BzATP	138-143	interleukin 1 beta	Homo sapiens	118-122
34497300-7	2021	BzATP significantly increased the protein release of TNF-alpha and the expression of TNFA and IL1B in monocyte-generated macrophages.	BzATP	0-5	interleukin 1 beta	Homo sapiens	94-98
34497300-8	2021	Besides, BzATP treatment significantly upregulated IL1B expression, reduced TNFA and IL23A expression, and TNF-alpha release in M1 macrophages from both groups.	BzATP	9-14	interleukin 1 beta	Homo sapiens	51-55
34497300-9	2021	Monocyte-generated and M1 macrophages from AS patients released higher TNF-alpha and expressed more IL1B in response to the same concentration of BzATP treatment respectively.	BzATP	146-151	interleukin 1 beta	Homo sapiens	100-104
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Berberine	122-131	interleukin 1 beta	Homo sapiens	267-271
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	hederagenin	133-144	interleukin 1 beta	Homo sapiens	267-271
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	shionone	146-154	interleukin 1 beta	Homo sapiens	267-271
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	kaempferol	159-169	interleukin 1 beta	Homo sapiens	267-271
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Luteolin	112-120	interleukin 1 beta	Homo sapiens	267-271
34078001-0	2021	Ferulic acid suppresses interleukin-1beta-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1alpha signaling pathway.	ferulic acid	0-12	interleukin 1 beta	Homo sapiens	24-41
34147477-4	2021	Our results showed that both icariin and icaritin significantly inhibited LPS-induced mRNA expressions of tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta).	icariin	29-36	interleukin 1 beta	Homo sapiens	144-161
34147477-4	2021	Our results showed that both icariin and icaritin significantly inhibited LPS-induced mRNA expressions of tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta).	icaritin	41-49	interleukin 1 beta	Homo sapiens	144-161
34153368-0	2021	Examination of neuroinflammatory cytokine interleukin-1 beta expression in the medial prefrontal cortex, amygdala, and hippocampus for the paradoxical effects of reward and aversion induced by morphine.	Morphine	193-201	interleukin 1 beta	Homo sapiens	42-60
34578957-0	2021	Kaempferol Blocks the Skin Fibroblastic Interleukin 1beta Expression and Cytotoxicity Induced by 12-O-tetradecanoylphorbol-13-acetate by Suppressing c-Jun N-terminal Kinase.	kaempferol	0-10	interleukin 1 beta	Homo sapiens	40-57
34578957-0	2021	Kaempferol Blocks the Skin Fibroblastic Interleukin 1beta Expression and Cytotoxicity Induced by 12-O-tetradecanoylphorbol-13-acetate by Suppressing c-Jun N-terminal Kinase.	Tetradecanoylphorbol Acetate	97-133	interleukin 1 beta	Homo sapiens	40-57
34370102-7	2021	Quantitative PCR results revealed the significantly higher mRNA level of IL1B and CD69 in fresh NP-treated groups compared to that of aged ZnO NP- and zinc chloride-treated groups.	Zinc Oxide	139-142	interleukin 1 beta	Homo sapiens	73-77
34489672-11	2021	In the frontal voxel, NAA was predicted by more IL-1B and less TNF-alpha, Cr by less TNF-alpha and more IL-5, and Glx by less TNF-alpha.	1-naphthaleneacetic acid	22-25	interleukin 1 beta	Homo sapiens	48-53
34489672-12	2021	In the parietal voxel, MI was predicted by more IL-10 and IL-8 and less IL-2, Cho by more TNF-alpha and less IL-2, NAA by more IL-1B and TNF-alpha and less IL-13, IL-2, and IL-7, and Cr by more IL-10 and less IL-2.	1-naphthaleneacetic acid	115-118	interleukin 1 beta	Homo sapiens	127-132
34405373-7	2021	The fold-regulation values for the following genes for LA-5 and LR-32 were, respectively, IL-12B (431.94 and 33.30), IL-1Beta (76.73 and 17.14), TNF-alpha (94.63 and 2.49), CXCL-8 (89.59 and 4.18), and TLR-2 (49.68 and 3.40).	Lawrencium	64-66	interleukin 1 beta	Homo sapiens	117-125
34440184-6	2021	In intermittent treatment, cortisol acted mainly as an anti-inflammatory hormone, repressing gene expression of kinin B1 receptors, interleukin-6, and interleukin-1beta.	Hydrocortisone	27-35	interleukin 1 beta	Homo sapiens	151-168
34370102-7	2021	Quantitative PCR results revealed the significantly higher mRNA level of IL1B and CD69 in fresh NP-treated groups compared to that of aged ZnO NP- and zinc chloride-treated groups.	zinc chloride	151-164	interleukin 1 beta	Homo sapiens	73-77
34430504-0	2021	Efficacy of Xanthan-Based Chlorhexidine Gel on the Levels of Interleukin-1beta in Chronic Periodontitis: An Interventional Study.	Chlorhexidine	26-39	interleukin 1 beta	Homo sapiens	61-78
34188699-5	2021	Compared with those in the vehicle (DMSO)-treated control cells, artesunate enhanced the apoptotic rate and increased lactate dehydrogenase release, reactive oxygen species and IL1b and IL18 levels in C918 cells.	Dimethyl Sulfoxide	36-40	interleukin 1 beta	Homo sapiens	177-181
34188699-5	2021	Compared with those in the vehicle (DMSO)-treated control cells, artesunate enhanced the apoptotic rate and increased lactate dehydrogenase release, reactive oxygen species and IL1b and IL18 levels in C918 cells.	Artesunate	65-75	interleukin 1 beta	Homo sapiens	177-181
34290670-8	2021	Also, teduglutide had no effect on high glucose/palmitate- or LPS-induced dysfunction in cultured human islets but dampened LPS-induced macrophage-dependent IL1B and IL10 expression, while its antagonist GLP-2(3-33) abolished such reduction.	teduglutide	6-17	interleukin 1 beta	Homo sapiens	157-161
34360711-5	2021	In the present study, we found that M1 macrophages mediate the pyroptosis in the ischemia/reperfusion (I/R) injured hearts and identified miRNA-762 as an important regulator of interleukin 1beta production and subsequent pyroptosis.	mirna-762	138-147	interleukin 1 beta	Homo sapiens	177-194
34170130-5	2021	PCZ-treated cells activated intracellular oxidative stress via cytochrome P450 and had higher mRNA levels of interleukin-1beta, tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-2, MMP-9, and transforming growth factor-beta (TGF-beta) than the control.	propiconazole	0-3	interleukin 1 beta	Homo sapiens	109-126
34430504-0	2021	Efficacy of Xanthan-Based Chlorhexidine Gel on the Levels of Interleukin-1beta in Chronic Periodontitis: An Interventional Study.	xanthan gum	12-19	interleukin 1 beta	Homo sapiens	61-78
34319853-7	2021	Significant decreases in interleukin- 1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels were obtained in cultures treated with FA-MTX-BSA NPs compared to the untreated culture in a dose-dependent pattern.	Methotrexate	172-175	interleukin 1 beta	Homo sapiens	25-44
34634848-0	2021	(Correlation between insufficiency or deficiency of vitamin D levels and interleukins 1beta and 6).	Vitamin D	52-61	interleukin 1 beta	Homo sapiens	73-97
34143493-0	2021	Interleukin 1 beta-induced calcium signaling via TRPA1 channels promotes mitogen-activated protein kinase-dependent mesangial cell proliferation.	Calcium	27-34	interleukin 1 beta	Homo sapiens	0-18
34446131-11	2021	Furthermore, the RP1R3V6/AMO92a complex decreased the TNF-alpha and interleukin-1beta (IL-1beta) levels more efficiently than did the PEI25k/AMO92a and R3V6/AMO92a complexes, decreasing the damage in the lungs.	amo92a	25-31	interleukin 1 beta	Homo sapiens	68-85
34087700-4	2021	Similarly, PS at a dosage of 20 and 40 mg/kg increased the concentrations of interleukin-1beta, interferon-gamma, interleukin-2, and interleukin-6 but decreased triglyceride, total cholesterol, and low-density lipoprotein cholesterol content of serum (P < 0.05).	Phytosterols	11-13	interleukin 1 beta	Homo sapiens	77-94
34145895-8	2021	The increased malondialdehyde (MDA) and Interleukin-1beta (IL-1beta), and decreased superoxide dismutase (SOD) were observed in the DOX group, while tVNS significantly prevented these changes.	Doxorubicin	132-135	interleukin 1 beta	Homo sapiens	40-57
34262463-10	2021	Collectively, our results indicate that the ROS-NLRP3 inflammasome-interleukin-1beta axis may contribute to platelet hyperactivity in active CD.	Reactive Oxygen Species	44-47	interleukin 1 beta	Homo sapiens	67-84
34145895-8	2021	The increased malondialdehyde (MDA) and Interleukin-1beta (IL-1beta), and decreased superoxide dismutase (SOD) were observed in the DOX group, while tVNS significantly prevented these changes.	tvns	149-153	interleukin 1 beta	Homo sapiens	40-57
34072123-5	2021	In the current study, we determined that treating interleukin-1 beta (IL-1beta-stimulated chondrocyte cells) with cardamonin significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) and significantly inhibited the expression of pro-inflammatory proteins, including inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2).	Nitric Oxide	162-174	interleukin 1 beta	Homo sapiens	50-68
34075738-7	2021	Our data confirmed that Ononin could alleviate TNF-alpha-induced RA-FLS and MH7A cells viability, increase cell apoptosis, decrease the production of pro-inflammatory cytokines like interleukin-1beta (IL-1beta) and interleukin 6 (IL-6), and further inhibit the abnormal activation of NF-kappaB and MAPK pathways.	calycosin-7-O-beta-D-glucoside	24-30	interleukin 1 beta	Homo sapiens	182-199
34414298-2	2021	In randomised trials in patients with coronary disease, canukinumab (an interleukin-1B antagonist) and colchicine (a tubulin inhibitor with pleiotropic anti-inflammatory effects) reduced recurrent vascular events.Hypothesis: Anti-inflammatory therapy with low-dose colchicine plus usual care will reduce recurrent vascular events in patients with non-severe, non-cardioembolic stroke and TIA compared with usual care alone.	Colchicine	265-275	interleukin 1 beta	Homo sapiens	72-86
34072123-5	2021	In the current study, we determined that treating interleukin-1 beta (IL-1beta-stimulated chondrocyte cells) with cardamonin significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) and significantly inhibited the expression of pro-inflammatory proteins, including inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2).	Dinoprostone	184-200	interleukin 1 beta	Homo sapiens	50-68
34072123-5	2021	In the current study, we determined that treating interleukin-1 beta (IL-1beta-stimulated chondrocyte cells) with cardamonin significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) and significantly inhibited the expression of pro-inflammatory proteins, including inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2).	Dinoprostone	202-206	interleukin 1 beta	Homo sapiens	50-68
35514301-10	2022	The results revealed that interleukin 1beta, bone morphogenetic protein 4, interleukin 6 and C-X-C motif chemokine ligand 12 had great potential to mediate the differential effects of VSCC-SCs and SCC-SCs on TAM infiltration.	tam	208-211	interleukin 1 beta	Homo sapiens	26-43
34268359-13	2021	Moreover, gene set enrichment analysis showed that lysosomes, cell cycle, and calcium signaling pathways were associated with the biological processes in which IL1B plays a role.	Calcium	78-85	interleukin 1 beta	Homo sapiens	160-164
34268359-16	2021	Furthermore, by affecting lysosomal, cell cycle, and calcium signaling pathways, IL1B may be one of the factors involved in endometrial repair and receptivity recovery.	Calcium	53-60	interleukin 1 beta	Homo sapiens	81-85
34092579-2	2021	OBJECTIVES: We aimed to evaluate the effect of cytokine interleukin-1beta (IL-1beta) as a key mediator of inflammation on multidrug resistance associated protein 2 (MRP2) expression and tamoxifen toxicity in estrogen receptor positive (ER+) MCF-7 breast cancer cells.	Tamoxifen	186-195	interleukin 1 beta	Homo sapiens	56-73
35182670-8	2022	In addition, the GB-N and GB-F significantly ameliorated the PA-inducible proinflammatory cytokines mRNA expression, such as tumor necrosis factor-alpha and interleukin-1beta, compared to the PA-treated hepatic cells (p < 0.05).	gb-n	17-21	interleukin 1 beta	Homo sapiens	157-174
35182670-8	2022	In addition, the GB-N and GB-F significantly ameliorated the PA-inducible proinflammatory cytokines mRNA expression, such as tumor necrosis factor-alpha and interleukin-1beta, compared to the PA-treated hepatic cells (p < 0.05).	gb-f	26-30	interleukin 1 beta	Homo sapiens	157-174
35182670-8	2022	In addition, the GB-N and GB-F significantly ameliorated the PA-inducible proinflammatory cytokines mRNA expression, such as tumor necrosis factor-alpha and interleukin-1beta, compared to the PA-treated hepatic cells (p < 0.05).	Palmitic Acid	61-63	interleukin 1 beta	Homo sapiens	157-174
35182670-8	2022	In addition, the GB-N and GB-F significantly ameliorated the PA-inducible proinflammatory cytokines mRNA expression, such as tumor necrosis factor-alpha and interleukin-1beta, compared to the PA-treated hepatic cells (p < 0.05).	Palmitic Acid	192-194	interleukin 1 beta	Homo sapiens	157-174
34069060-10	2021	Luteinizing hormone, through interleukin-1beta, stimulates the nerve growth factor-tropomyosin receptor kinase A axis in the ovarian cells and promotes tropomyosin receptor kinase A and nerve growth factor gene expression and prostaglandin E2 release.	Dinoprostone	226-242	interleukin 1 beta	Homo sapiens	29-46
34141982-11	2021	We found that 13-HODE and 12,13-EpOME (elevated and decreased, respectively) in combination with elevated interleukin-1beta as independent predictors can effectively predict altered liver function as defined by elevated bilirubin levels.	Bilirubin	220-229	interleukin 1 beta	Homo sapiens	106-123
35314903-12	2022	Also, the in vitro experiment showed that UA induced epithelial-to-mesenchymal transition (EMT) and production of IL-1, IL-6, and TGF-beta in A549 cells.	Uric Acid	42-44	interleukin 1 beta	Homo sapiens	114-118
35144170-1	2022	In this study, protein-imprinted sensors were electrochemically fabricated on screen-printed carbon electrodes (SPCEs) for the cytokine interleukin-1beta (IL-1beta) detection.	Carbon	93-99	interleukin 1 beta	Homo sapiens	136-153
35170144-10	2022	Sputum inflammatory markers interleukin-1beta (P < 0.001), interleukin-8 (P < 0.001) and tumour necrosis factor-alpha (P = 0.003) were lower with gentamicin.	Gentamicins	146-156	interleukin 1 beta	Homo sapiens	28-45
35134851-7	2022	The mRNA levels of representative M1 markers (interleukin-1beta and interleukin-6) and M2 markers (interleukin-10 and arginase-1) were quantified with qPCR in M0 macrophages being stimulated with sulprostone (an EP3 agonist) or L-798, 106 (an EP3 antagonist).	sulprostone	196-207	interleukin 1 beta	Homo sapiens	46-63
35513427-4	2022	Stimulation of human mesangial cells with high glucose primed the inflammasome-driven interleukin 1 beta (IL-1beta) secretion, which in turn stimulated platelet-derived growth factor (PDGF-BB) release.	Glucose	47-54	interleukin 1 beta	Homo sapiens	86-104
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Cholesterol	139-150	interleukin 1 beta	Homo sapiens	291-295
35525893-10	2022	CRE and TC supplementation remarkably downregulated the interleukin-1alpha, tumor necrosis factor-alpha, interleukin-1beta, acetylcholinesterase, and beta-secretase pathological gene expression.	Technetium	8-10	interleukin 1 beta	Homo sapiens	105-122
35562512-4	2022	Vincristine-induced PN involves impaired calcium homeostasis, an increase of reactive oxygen species (ROS), and the upregulation of tumor necrosis factor-alpha (TNF-alpha), and interleukin 1 beta (IL-1beta) expression.	Vincristine	0-11	interleukin 1 beta	Homo sapiens	177-195
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	interleukin 1 beta	Homo sapiens	291-295
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Arachidonic Acid	89-101	interleukin 1 beta	Homo sapiens	291-295
35465785-0	2022	Release of Interleukin-1beta evaluation among mineral oil mist-exposed workers.	Mineral Oil	46-57	interleukin 1 beta	Homo sapiens	11-28
35255378-7	2022	A strong positive correlation of GSS score was noted with IL-17(r = 0.7), IL-6 (r = 0.7), IL-1b (r = 0.7), and IL-33 (r = 0.6).	gss	33-36	interleukin 1 beta	Homo sapiens	90-95
35600853-8	2022	PN-G also reduced the levels of interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta), in a dose dependent manner, in inflamed human macrophagic THP-1 cells, thereby, reaffirming its anti-inflammatory property at cytosafe concentrations.	pn-g	0-4	interleukin 1 beta	Homo sapiens	57-75
35182690-8	2022	Concomitantly, adjudin treatment significantly reduced SE-induced inflammatory processes, as confirmed by changes in the expression of inflammatory mediators such as tumor necrosis factor-alpha, interleukin-1beta, and arginase-1.	1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide	15-22	interleukin 1 beta	Homo sapiens	195-212
35465785-14	2022	Overall, the results of this study suggested that Interleukin-1beta evaluation in mineral oil mist exposure could be considered as both an acute and chronic inflammation marker.	Mineral Oil	82-93	interleukin 1 beta	Homo sapiens	50-67
35490742-8	2022	Instead, the SE -derived serine protease Esp was identified as a pro-IL-1beta processing factor leading to a proteolytic maturation of active IL-1beta.	Serine	25-31	interleukin 1 beta	Homo sapiens	65-77
35572519-10	2022	Regarding the direct effect of BHB on inflammasome activation, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha secretion in response to adenosine triphosphate or palmitate stimulation in human macrophages decreased significantly after isocaloric KD.	3-Hydroxybutyric Acid	31-34	interleukin 1 beta	Homo sapiens	63-80
35572519-10	2022	Regarding the direct effect of BHB on inflammasome activation, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha secretion in response to adenosine triphosphate or palmitate stimulation in human macrophages decreased significantly after isocaloric KD.	Adenosine	149-158	interleukin 1 beta	Homo sapiens	63-80
35572519-10	2022	Regarding the direct effect of BHB on inflammasome activation, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha secretion in response to adenosine triphosphate or palmitate stimulation in human macrophages decreased significantly after isocaloric KD.	Palmitates	175-184	interleukin 1 beta	Homo sapiens	63-80
35593365-12	2022	The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B.	Quercetin	27-36	interleukin 1 beta	Homo sapiens	89-93
35625225-6	2022	Furthermore, cefiderocol reduces interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and TNF-alpha release in peripheral blood mononuclear cells (PBMCs) following LPS stimulation in a dose-dependent manner.	cefiderocol	13-24	interleukin 1 beta	Homo sapiens	55-72
35530351-0	2022	IL1 Pathway in HPV-Negative HNSCC Cells Is an Indicator of Radioresistance After Photon and Carbon Ion Irradiation Without Functional Involvement.	Carbon	92-98	interleukin 1 beta	Homo sapiens	0-3
35471556-3	2022	MV treatment also decreased the production of pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in C6 glial cells stimulated by LPS/IFN-gamma.	mv	0-2	interleukin 1 beta	Homo sapiens	82-99
35593365-12	2022	The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B.	wogonin	41-48	interleukin 1 beta	Homo sapiens	89-93
35593365-14	2022	The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01).	Quercetin	61-70	interleukin 1 beta	Homo sapiens	30-34
35593365-14	2022	The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01).	wogonin	74-81	interleukin 1 beta	Homo sapiens	30-34
35436742-12	2022	Levels of interleukin-1beta (IL-1beta) were increased at varied time points after ATRA treatment.	Tretinoin	82-86	interleukin 1 beta	Homo sapiens	10-27
35248552-10	2022	In addition, quercetin exhibits anti-inflammatory activity by reducing tumor necrosis factor-alpha(TNF-alpha)and interleukin-1beta(IL-1beta)levels.	Quercetin	13-22	interleukin 1 beta	Homo sapiens	113-130
35462520-2	2022	In addition, a high carbohydrate diet can increase liver metabolic burden, increase mitochondrial oxidative phosphorylation, leading to oxidative stress, generate new fat during adenosine triphosphate synthesis, and thus resulting in ectopic fat accumulation, which further activate nuclear factor-kappaB signaling pathway and release inflam- matory factors such as tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-6, and so on.	Carbohydrates	20-32	interleukin 1 beta	Homo sapiens	395-412
35563682-6	2022	Rapa-ASCs further upregulated TNFalpha-stimulated gene-6 (TSG-6) and interleukin-1 beta (IL-1beta), indicating additional enhancement of immunomodulatory potential.	rapa-ascs	0-9	interleukin 1 beta	Homo sapiens	69-87
35404445-1	2022	The present study aims to explore the potential function of ketorolac tromethamine in treating osteoarthritis (OA) by examining its effects on interleukin-1beta (IL-1beta)-triggered cellular senescence in chondrocytes.	Ketorolac	60-69	interleukin 1 beta	Homo sapiens	143-160
35404445-1	2022	The present study aims to explore the potential function of ketorolac tromethamine in treating osteoarthritis (OA) by examining its effects on interleukin-1beta (IL-1beta)-triggered cellular senescence in chondrocytes.	Tromethamine	70-82	interleukin 1 beta	Homo sapiens	143-160
35454123-7	2022	Finally, PRS CK STORM prevents LPS-induced TNF-A and IL-1Beta secretion from PBMC and from THP-1 cells at the same level as hydrocortisone, demonstrating its anti-inflammatory potency.	Hydrocortisone	124-138	interleukin 1 beta	Homo sapiens	53-61
35366876-11	2022	PRM verified that the apoptosis-related proteins HMOX1 and GCLM were up-regulated and IL1B was down-regulated in BCPAP cells treated with parthenolide.	parthenolide	138-150	interleukin 1 beta	Homo sapiens	86-90
35189144-2	2022	Here, we explore the synergy that occurs between synthetic glucocorticoids (dexamethasone, budesonide) and pro-inflammatory cytokines (IL1B, TNF) on the expression of the toll-like receptor 2 (TLR2).	Budesonide	91-101	interleukin 1 beta	Homo sapiens	135-139
35378052-0	2022	Ellagic acid attenuates interleukin-1beta-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.	Ellagic Acid	0-12	interleukin 1 beta	Homo sapiens	24-41
35351143-5	2022	It has been reported that the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing (NLRP) 3 inflammasome, which contributes to the activation of interleukin-1 beta (IL-1beta), might be related to the progression of endometriosis.	Leucine	73-80	interleukin 1 beta	Homo sapiens	184-202
35301059-10	2022	Moreover, we found that cadmium exposure induces the pro-inflammatory state of the adipocytes by enhancing the expression of genes such as IL-6, IL-1B and CCL2, cytokines also induced in obesity.	Cadmium	24-31	interleukin 1 beta	Homo sapiens	145-150
35364429-7	2022	These vitamins can also modulate genes induced by DAB (IL1B, IL6, IL10, iNOS, COX2, NFkappaB, GSK3B, TNF, and APP) in SH-SY5Y cells.	3,3'-Diaminobenzidine	50-53	interleukin 1 beta	Homo sapiens	55-59
35260353-0	2022	Interleukin-1 beta is a potential mediator of airway nitric oxide deficiency in cystic fibrosis.	Nitric Oxide	53-65	interleukin 1 beta	Homo sapiens	0-18
35453501-8	2022	Additionally, the treatment with melatonin restored tight-junction expression and reduced pro-inflammatory cytokine levels, such as interleukin-1beta and interleukin-12.	Melatonin	33-42	interleukin 1 beta	Homo sapiens	132-149
35399295-10	2022	The mRNA levels for IL-1b, IL-6, and TNF-alpha increased significantly at the end of 2-h exposure of A549 cells to the positive control AgNP aerosols.	agnp	136-140	interleukin 1 beta	Homo sapiens	20-25
35285601-0	2022	Whole Salivary Cotinine Levels and Interleukin 1-beta Levels among Young Adults Involuntarily Exposed to Vapor from Electronic Nicotine Delivery Systems.	Nicotine	127-135	interleukin 1 beta	Homo sapiens	35-53
35164664-6	2022	Nintedanib reduced the production of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in TNF-alpha-induced CHON-001 chondrocytes.	nintedanib	0-10	interleukin 1 beta	Homo sapiens	89-106
35236262-5	2022	The co-activation of toll-like receptors 4 (TLR4) by lipopolysaccharide, a constituent of the cell membrane of gram negative bacteria, and the P2X7R by ATP leads to the generation and release of the pro-inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha.	Adenosine Triphosphate	152-155	interleukin 1 beta	Homo sapiens	226-243
35085532-5	2022	Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF.	Berberine	0-9	interleukin 1 beta	Homo sapiens	138-142
35299960-0	2022	miR-218-5p Induces Interleukin-1beta and Endovascular Trophoblast Differentiation by Targeting the Transforming Growth Factor beta-SMAD2 Pathway.	mir-218-5p	0-10	interleukin 1 beta	Homo sapiens	19-36
35299960-9	2022	On the other hand, overexpression of SMAD2 reduced IL1beta levels and blocked the stimulatory effects of miR-218-5p on IL1B expression, trophoblast migration and endothelial-like network formation.	mir-218-5p	105-115	interleukin 1 beta	Homo sapiens	119-123
35140721-6	2022	Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system.	Phorbol Esters	151-164	interleukin 1 beta	Homo sapiens	265-283
35335908-4	2022	The biochemical analysis indicated that either alcohol or ATOR or together in combination produced a significant increase in the nucleotide-binding domain-like receptor 3 (NLRP3), interleukin-1beta (IL-1beta) miRNA155 expression levels in the frontal cortex of the brain tissue.	Alcohols	47-54	interleukin 1 beta	Homo sapiens	180-197
35335908-4	2022	The biochemical analysis indicated that either alcohol or ATOR or together in combination produced a significant increase in the nucleotide-binding domain-like receptor 3 (NLRP3), interleukin-1beta (IL-1beta) miRNA155 expression levels in the frontal cortex of the brain tissue.	Atorvastatin	58-62	interleukin 1 beta	Homo sapiens	180-197
35335908-8	2022	ASA significantly decreased the expression levels of miRNA155, NLRP3, and IL1B, and produced a significant decrease in caspase-8 immunoreaction in the neurons and glial cells of the frontal cortex with a reduction in the process of neuroinflammation and neuronal damage.	Aspirin	0-3	interleukin 1 beta	Homo sapiens	74-78
35326266-7	2022	We investigated how a caloric restriction mimetic and glycolysis inhibitor, 2-deoxyglucose (2-DG), affects interleukin 1beta-induced inflammatory gene expression in human astrocytes.	Deoxyglucose	92-96	interleukin 1 beta	Homo sapiens	107-124
35038495-6	2022	The astaxanthin-loaded CCs could significantly inhibit the expression of inflammation factors such as interleukin-1beta, interleukin-6, tumor necrosis factor alpha, cyclooxygenase-2, myeloperoxidase, inducible nitric oxide synthase, and nitric oxide.	astaxanthine	4-15	interleukin 1 beta	Homo sapiens	102-119
35005769-13	2022	Moreover, both the overexpression of miR-24-3p and the suppression of NKAP can inhibit the NF-kB/pro-IL-1beta signaling pathway.	mir-24-3p	37-46	interleukin 1 beta	Homo sapiens	97-109
35195403-8	2022	Finally, ORV, GN, and their glucuronide metabolites (mainly at the C-3 position) decreased nitric oxide, reactive oxygen species, interleukin 1beta, and tumor necrosis factor alpha production in lipopolysaccharide-stimulated macrophages.	Glucuronides	28-39	interleukin 1 beta	Homo sapiens	130-147
35183882-8	2022	Furthermore, boron citrate in combination with oleoylethanolamide resulted in a significant reduction in the high-sensitivity C-reactive protein and interleukin-1beta concentrations (p = 0.031 and p = 0.027, respectively).	BORON CITRATE	13-26	interleukin 1 beta	Homo sapiens	149-166
35183882-8	2022	Furthermore, boron citrate in combination with oleoylethanolamide resulted in a significant reduction in the high-sensitivity C-reactive protein and interleukin-1beta concentrations (p = 0.031 and p = 0.027, respectively).	oleoylethanolamide	47-65	interleukin 1 beta	Homo sapiens	149-166
35115408-8	2022	Our findings corroborate the electrostatic influence of IL-1 transport exerted by the GSDMD pore and reveal extrinsic factors, including lipid and salt, that affect the electrostatic environment.	Salts	147-151	interleukin 1 beta	Homo sapiens	56-60
34998604-4	2022	We found that gene expression of the proinflammatory cytokine Il1b and the downstream transcription factor Irf7 was markedly upregulated in skin tissues after sdMN application.	sdmn	159-163	interleukin 1 beta	Homo sapiens	62-66
35164046-6	2022	In addition, the inhibitory effects of both doses of MiodesinTM (10 microg/mL and 200 microg/mL) resulted in reduced secretion of interleukin-1beta (IL-1beta), IL-6, IL-8, tumor necrosis factor alpha (TNF-alpha) (24 h, 48 h, and 72 h) and CCL2, CCL3, and CLL5 (p < 0.05) by VK2 E6/E7 cells.	miodesintm	53-63	interleukin 1 beta	Homo sapiens	130-147
35140721-6	2022	Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system.	Tetradecanoylphorbol Acetate	166-169	interleukin 1 beta	Homo sapiens	265-283
35061107-0	2022	Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival.	Pilocarpine	81-92	interleukin 1 beta	Homo sapiens	36-54
35061107-7	2022	We found that knocking down Il1b prior to pilocarpine injection increased the mortality rate of treated animals.	Pilocarpine	42-53	interleukin 1 beta	Homo sapiens	28-32
35061107-8	2022	Furthermore, we observed that, when exposing the animals to more Il1b by silencing its endogenous antagonist Il1rn, there was a better response to status epilepticus with decreased animal mortality in the acute phase of the PILO model.	Pilocarpine hydrochloride	224-228	interleukin 1 beta	Homo sapiens	65-69
35061107-10	2022	Furthermore, our results provide suggestive evidence that modulating endogenous Il1b improves animal survival in the acute phase of the PILO model and may have effects that extend into the chronic phase.	Pilocarpine hydrochloride	136-140	interleukin 1 beta	Homo sapiens	80-84
35355720-9	2022	There was a significant association of resveratrol with the levels of blood glucose (BG), serum creatinine (Scr), blood urea nitrogen (BUN), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), and interleukin-1beta (IL-1beta).	Resveratrol	39-50	interleukin 1 beta	Homo sapiens	261-278
34968169-0	2022	The protective effects of etomidate against interleukin-1beta (IL-1beta)-induced oxidative stress, extracellular matrix alteration and cellular senescence in chondrocytes.	Etomidate	26-35	interleukin 1 beta	Homo sapiens	44-61
34974796-0	2022	The protective effects of dezocine on interleukin-1beta-induced inflammation, oxidative stress and apoptosis of human nucleus pulposus cells and the possible mechanisms.	dezocine	26-34	interleukin 1 beta	Homo sapiens	38-55
35023445-11	2022	In vitro, co-incubation with a Gal-3 inhibitor (GB1107, 10 microM) led to a significant reduction in both interleukin-1beta and tumour necrosis factor-alpha secretion from FLS monocultures (both p < 0.05) and decreased monocyte-derived osteoclastogenesis compared with controls (both p < 0.05).	GB1107	48-54	interleukin 1 beta	Homo sapiens	106-123
35057081-10	2022	In addition, farnesol drastically increased the synthesis of COL II (2.5-fold) and GAG (15-fold) on interleukin-1beta-induced dedifferentiated chondrocytes.	Farnesol	13-21	interleukin 1 beta	Homo sapiens	100-117
35057081-10	2022	In addition, farnesol drastically increased the synthesis of COL II (2.5-fold) and GAG (15-fold) on interleukin-1beta-induced dedifferentiated chondrocytes.	col ii	61-67	interleukin 1 beta	Homo sapiens	100-117
35057081-10	2022	In addition, farnesol drastically increased the synthesis of COL II (2.5-fold) and GAG (15-fold) on interleukin-1beta-induced dedifferentiated chondrocytes.	Glycosaminoglycans	83-86	interleukin 1 beta	Homo sapiens	100-117
34967261-8	2022	Sitagliptin inhibited HG-induced production of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and interleukin-8 (IL-8) in HrGECs.	Sitagliptin Phosphate	0-11	interleukin 1 beta	Homo sapiens	74-91
34967261-8	2022	Sitagliptin inhibited HG-induced production of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and interleukin-8 (IL-8) in HrGECs.	Mercury	22-24	interleukin 1 beta	Homo sapiens	74-91