PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25525879-7	2014	We demonstrate SIRT4-mediated regulation of DLAT lipoyl levels and PDH activity in cells and in vivo, in mouse liver.	Alpha Lipoyl	49-55	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	44-48
29307284-9	2018	2-nonyamide is another xenobiotic that also has the optimal chemical structure for xenobiotic modification of the PDC-E2 epitope, as demonstrated by the enhanced epitope recognition with AMA-positive PBC sera.	2-nonyamide	0-11	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	114-120
22519590-3	2012	In particular, following immunization with 2-octynoic acid (a synthetic chemical mimic of lipoic acid-lysine located within the inner domain of PDC-E2) coupled to bovine serum albumin (BSA), several strains of mice develop typical anti-mitochondrial autoantibodies and portal inflammation.	2-octynoic acid	43-58	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	144-150
22920894-2	2012	The PBC-related autoepitope of PDC-E2 contains lipoic acid, and previous work has demonstrated that mimics of lipoic acid following immunization of mice lead to a PBC-like disease.	Thioctic Acid	47-58	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	31-37
22920894-2	2012	The PBC-related autoepitope of PDC-E2 contains lipoic acid, and previous work has demonstrated that mimics of lipoic acid following immunization of mice lead to a PBC-like disease.	Thioctic Acid	110-121	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	31-37
22519590-3	2012	In particular, following immunization with 2-octynoic acid (a synthetic chemical mimic of lipoic acid-lysine located within the inner domain of PDC-E2) coupled to bovine serum albumin (BSA), several strains of mice develop typical anti-mitochondrial autoantibodies and portal inflammation.	lipoic acid-lysine	90-108	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	144-150
20224397-6	2010	Recently, we have also established a successful murine model following the immunization with a chemical mimicry of the lipoyl-lysine residue of the E2 component of PDC-E2.	lipoyllysine	119-132	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	164-170
21397011-7	2011	IL-3-induced tyrosine-phosphorylated STAT5 associated with nuclear PDC-E2 in co-immunoprecipitation analysis.	Tyrosine	13-21	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	67-73
18290765-9	2008	However, exogenous administration of queuine to DLAT mouse improves the activities of antioxidant enzymes.	queuine	37-44	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	48-52
18563844-5	2008	We have also demonstrated that several chemical xenobiotics, chosen based on quantitative structural activity relationship analysis and rigorous epitope analysis, when coupled to the lysine residue that normally binds the lipoic acid cofactor of PDC-E2, reacts as well or better to PBC sera than native autoantigen.	Lysine	183-189	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	246-252
18563844-5	2008	We have also demonstrated that several chemical xenobiotics, chosen based on quantitative structural activity relationship analysis and rigorous epitope analysis, when coupled to the lysine residue that normally binds the lipoic acid cofactor of PDC-E2, reacts as well or better to PBC sera than native autoantigen.	Thioctic Acid	222-233	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	246-252
18057548-10	2007	For this DLAT cancerous mouse, U87 cell line and HepG2 cell line are treated with different concentrations of queuine and the effect of queuine on cell proliferation and apoptosis are studied.	queuine	110-117	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	9-13
17564608-4	2007	Insertional inactivation of the dltA gene resulted in complete depletion of D-alanine substitution of lipoteichoic acids.	dalbergioidin	76-85	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	32-36
17564608-4	2007	Insertional inactivation of the dltA gene resulted in complete depletion of D-alanine substitution of lipoteichoic acids.	lipoteichoic acid	102-120	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	32-36
18347422-10	2008	The present study is aimed to investigate queuine mediated modulation in the activity of lactate dehydrogenase and expression of proto-oncogenes like c-myc and c-fos in T-cell lymphoma (DLAT) induced cancerous mouse.	queuine	42-49	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	186-190
18347422-11	2008	The results indicate that elevated lactate dehydrogenase activity is brought down by queuine treatments and the elevated levels of c-Myc and c-Fos in DLAT cancerous mouse are down-regulated, suggesting that queuine inhibits anaerobic metabolism and cell proliferation.	queuine	207-214	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	150-154
16368957-2	2006	To defend itself against oxidative/nitrosative stress, M. tuberculosis expresses an NADH-dependent peroxidase and peroxynitrite reductase that is encoded by ahpC, ahpD, lpd, and dlaT.	NAD	84-88	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	178-182
35362381-12	2022	CONCLUSIONS: Curcumin decreased the fructose-induced glycation level of the ACO2, NDUFS7, and DLAT proteins.	Curcumin	13-21	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	94-98
35397283-13	2022	Alo also inhibited the binding of RIPK3 and PDC-E1alpha, PDC-E1beta, PDC-E2, and PDC-E3 and the ROS production in LPS-treated MLE-12 cells.	aloperine	0-3	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	69-75
11849532-1	2002	The dlt operon of Gram-positive bacteria comprises four genes (dltA, dltB, dltC and dltD) that catalyse the incorporation of D-alanine residues into the cell wall-associated lipoteichoic acids (LTAs).	dalbergioidin	125-134	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	63-67
11849532-1	2002	The dlt operon of Gram-positive bacteria comprises four genes (dltA, dltB, dltC and dltD) that catalyse the incorporation of D-alanine residues into the cell wall-associated lipoteichoic acids (LTAs).	lipoteichoic acid	174-192	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	63-67
11584357-3	2001	We immunized mice with PDC-E2 to obtain 13 HmAbs, including 4 IgG(2) and 9 IgM isotypes.	hmabs	43-48	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	23-29
35362381-12	2022	CONCLUSIONS: Curcumin decreased the fructose-induced glycation level of the ACO2, NDUFS7, and DLAT proteins.	Fructose	36-44	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	94-98