PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
9419418-4	1997	Moreover, in the DN16 cell line, which exhibits the lowest PKA activity among the mutant cell lines [22% of wild type (WT) at 1 microM cAMP], there was a significant decrease in the cAMP-associated activation of the LAMB1 gene DNase I hypersensitivity site 2 enhancer, as measured by chloramphenicol acetyl transferase assays.	Cyclic AMP	182-186	laminin subunit beta 1	Homo sapiens	216-221
31963361-9	2020	The administration of cyclosporine A was followed by down-regulation of other genes: COL7A1, the transmembrane receptors ITGB2 and ITGB4, and the basement membrane constituents LAMA2 and LAMB1.	Cyclosporine	22-36	laminin subunit beta 1	Homo sapiens	187-192
2163993-1	1990	Retinoic acid (RA) treatment of F-9 embryonal carcinoma cells resulted in cell flattening and increased production of laminin B1 chain, both indicating differentiation to endoderm-like cells.	Tretinoin	0-13	laminin subunit beta 1	Homo sapiens	118-134
2163993-1	1990	Retinoic acid (RA) treatment of F-9 embryonal carcinoma cells resulted in cell flattening and increased production of laminin B1 chain, both indicating differentiation to endoderm-like cells.	Tretinoin	15-17	laminin subunit beta 1	Homo sapiens	118-134
35119561-7	2022	Combined with in vitro experiments, we found that an excessive H2S concentration promotes the expression of STAT1 and EGFR in HT22 and MML1 cells by inhibiting the expression of LAMB1.	Deuterium	63-66	laminin subunit beta 1	Homo sapiens	178-183
2527512-2	1989	This binding can be inhibited competitively by a specific pentapeptide sequence (Tyr-Ile-Gly-Ser-Arg) of the laminin B1 chain, and this peptide can prevent metastasis formation in vivo.	tyrosyl-isoleucyl-glycyl-seryl-arginine	81-100	laminin subunit beta 1	Homo sapiens	109-125
33435161-9	2021	U0126, an extracellular signal-regulated kinase (ERK) inhibitor, regulated the expression of LAMB1 in gastric cancer cells.	U 0126	0-5	laminin subunit beta 1	Homo sapiens	93-98
19094985-4	2009	The results indicated that atRA treatment up-regulated de novo synthesis of collagen type I, but decreased that of laminin beta1 in a dose-dependent manner.	Tretinoin	27-31	laminin subunit beta 1	Homo sapiens	115-128
30920297-13	2019	NEW & NOTEWORTHY Prioritized liver fibrosis-specific genes THBS2, COL4A2, ITGAV, LAMB1, and PDGFRA were identified and significantly associated with liver fibrosis progression and could be combined to discriminate liver fibrosis stages regardless of any etiology.	Adenosine Monophosphate	5-8	laminin subunit beta 1	Homo sapiens	85-90
30816547-10	2019	Further molecular docking simulation suggested a relatively stable binding selectivity between Bepridil and eight proteins (CRK, FGFR4, LAMB1, PIK3R2, CD47, ELANE, HPGD, and PRKCB).	Bepridil	95-103	laminin subunit beta 1	Homo sapiens	136-141
25257191-4	2015	In a public database, we found that laminin chain genes LAMA1, LAMA3, LAMB1 and LAMB4 had mononucleotide repeats in the coding sequences that might be mutation targets in the cancers with microsatellite instability (MSI).	mononucleotide	90-104	laminin subunit beta 1	Homo sapiens	70-75
20939100-6	2010	We predict that laminin beta(1) and gamma(1) LN domains share the galactose-binding domain-like fold.	Galactose	66-75	laminin subunit beta 1	Homo sapiens	16-44
17259394-0	2007	High glucose, high insulin, and their combination rapidly induce laminin-beta1 synthesis by regulation of mRNA translation in renal epithelial cells.	Glucose	5-12	laminin subunit beta 1	Homo sapiens	65-78
17259394-2	2007	We investigated regulation of laminin-beta1 synthesis in murine renal proximal tubular epithelial cells by 30 mmol/l glucose (high glucose), 1 nmol/l insulin (high insulin), and their combination (high glucose+high insulin), simulating conditions observed during progression of type 2 diabetes.	Glucose	117-124	laminin subunit beta 1	Homo sapiens	30-43
17259394-3	2007	Compared with 5 mmol/l glucose and no insulin (control), high glucose alone, high insulin alone, or high glucose+high insulin together increased laminin-beta1 chain protein synthesis within 5 min, lasting for up to 60 min with no change in laminin-beta1 mRNA levels.	Glucose	62-69	laminin subunit beta 1	Homo sapiens	145-158
17259394-3	2007	Compared with 5 mmol/l glucose and no insulin (control), high glucose alone, high insulin alone, or high glucose+high insulin together increased laminin-beta1 chain protein synthesis within 5 min, lasting for up to 60 min with no change in laminin-beta1 mRNA levels.	Glucose	62-69	laminin subunit beta 1	Homo sapiens	145-158
17259394-4	2007	Cycloheximide, but not actinomycin-D, abrogated increased laminin-beta1 synthesis.	Cycloheximide	0-13	laminin subunit beta 1	Homo sapiens	58-71
16690806-3	2006	Treatment of human endometrial stromal cells with hormones (estradiol and medroxyprogesterone acetate) plus dibutyryl cAMP (H+dbcAMP) for 48 h increased expression of IGFBP1, PRL, TIMP3, CNR1, and DCN but not LAMB1, as measured by real-time PCR.	Estradiol	60-69	laminin subunit beta 1	Homo sapiens	209-214
16690806-3	2006	Treatment of human endometrial stromal cells with hormones (estradiol and medroxyprogesterone acetate) plus dibutyryl cAMP (H+dbcAMP) for 48 h increased expression of IGFBP1, PRL, TIMP3, CNR1, and DCN but not LAMB1, as measured by real-time PCR.	Medroxyprogesterone Acetate	74-101	laminin subunit beta 1	Homo sapiens	209-214
16690806-3	2006	Treatment of human endometrial stromal cells with hormones (estradiol and medroxyprogesterone acetate) plus dibutyryl cAMP (H+dbcAMP) for 48 h increased expression of IGFBP1, PRL, TIMP3, CNR1, and DCN but not LAMB1, as measured by real-time PCR.	Cyclic AMP	118-122	laminin subunit beta 1	Homo sapiens	209-214
17259394-7	2007	High glucose, high insulin, and high glucose+high insulin increased Erk phosphorylation, which is an upstream regulator of eIF4E phosphorylation, and PD098059, which is a MEK inhibitor that blocks Erk activation, abolished laminin-beta1 synthesis.	Glucose	37-44	laminin subunit beta 1	Homo sapiens	223-236
17259394-7	2007	High glucose, high insulin, and high glucose+high insulin increased Erk phosphorylation, which is an upstream regulator of eIF4E phosphorylation, and PD098059, which is a MEK inhibitor that blocks Erk activation, abolished laminin-beta1 synthesis.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	150-158	laminin subunit beta 1	Homo sapiens	223-236
17259394-8	2007	This is the first demonstration of rapid increment in laminin-beta1 synthesis by regulation of its mRNA translation by cells exposed to high glucose, high insulin, or high glucose+high insulin.	Glucose	141-148	laminin subunit beta 1	Homo sapiens	54-67
17259394-8	2007	This is the first demonstration of rapid increment in laminin-beta1 synthesis by regulation of its mRNA translation by cells exposed to high glucose, high insulin, or high glucose+high insulin.	Glucose	172-179	laminin subunit beta 1	Homo sapiens	54-67
16690806-3	2006	Treatment of human endometrial stromal cells with hormones (estradiol and medroxyprogesterone acetate) plus dibutyryl cAMP (H+dbcAMP) for 48 h increased expression of IGFBP1, PRL, TIMP3, CNR1, and DCN but not LAMB1, as measured by real-time PCR.	Bucladesine	126-132	laminin subunit beta 1	Homo sapiens	209-214
16690806-9	2006	LAMB1, which was unresponsive to FOXO1A, decreased when H+dbcAMP was added.	h+dbcamp	56-64	laminin subunit beta 1	Homo sapiens	0-5
11791895-3	2001	METHODS: The major fluvoxamine metabolite, the 5-demethoxylated carboxylic acid metabolite, was analyzed in urine from 50 healthy volunteers after intake of a single oral dose of 50 mg fluvoxamine, and the formation clearance for the metabolite (CLm) was calculated.	Fluvoxamine	19-30	laminin subunit beta 1	Homo sapiens	246-249
11791895-11	2001	CLm decreased with increasing fluvoxamine dosage, but the decrease in oral clearance was even higher.	Fluvoxamine	30-41	laminin subunit beta 1	Homo sapiens	0-3
10623479-8	2000	However, following immunoaffinity purification on a laminin beta1 antibody-Sepharose column, a 200-kDa band was readily detected by the antibodies to laminin alpha4 chain.	Sepharose	75-84	laminin subunit beta 1	Homo sapiens	52-65
10585296-4	1999	Immunoaffinity purification on a laminin beta1 antibody-Sepharose column yielded polypeptides of 230, 220, 200, and 180 kDa from platelet lysates.	Sepharose	56-65	laminin subunit beta 1	Homo sapiens	33-46