PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31125123-4	2020	VPS33B overexpression suppressed CRC proliferation, intrahepatic metastasis and chemoresistance of cisplatin (DDP) in vivo and in vitro through modulating the epidermal growth factor receptor (EGFR)/RAS/ERK/c-Myc/p53/miR-133a-3p feedback loop and the downstream cell cycle or EMT-related factors.	Cisplatin	99-108	VPS33B late endosome and lysosome associated	Homo sapiens	0-6
31125123-0	2020	VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer.	Nicotine	31-39	VPS33B late endosome and lysosome associated	Homo sapiens	0-6
31125123-4	2020	VPS33B overexpression suppressed CRC proliferation, intrahepatic metastasis and chemoresistance of cisplatin (DDP) in vivo and in vitro through modulating the epidermal growth factor receptor (EGFR)/RAS/ERK/c-Myc/p53/miR-133a-3p feedback loop and the downstream cell cycle or EMT-related factors.	Cisplatin	110-113	VPS33B late endosome and lysosome associated	Homo sapiens	0-6
31479177-7	2019	Serum bile acid profiles of our VPS33B/VIPAS39 mutated patients revealed similar changes to primary defect of bile salt export pump, among which those with isolated cholestasis phenotype had a higher level of total secondary bile acids than that with typical ARC phenotype, indicating the partial residual function of VPS33B.	Bile Acids and Salts	6-15	VPS33B late endosome and lysosome associated	Homo sapiens	32-38
33997178-0	2021	VPS33B suppresses lung adenocarcinoma metastasis and chemoresistance to cisplatin.	Cisplatin	72-81	VPS33B late endosome and lysosome associated	Homo sapiens	0-6
33997178-3	2021	Overexpressed VPS33B was shown to reduce the migration, invasion, metastasis, and chemoresistance of LUAD cells to cisplatin (DDP) in vivo and in vitro.	Cisplatin	115-124	VPS33B late endosome and lysosome associated	Homo sapiens	14-20
33997178-3	2021	Overexpressed VPS33B was shown to reduce the migration, invasion, metastasis, and chemoresistance of LUAD cells to cisplatin (DDP) in vivo and in vitro.	Cisplatin	126-129	VPS33B late endosome and lysosome associated	Homo sapiens	14-20
33997178-10	2021	Finally, we observed that nicotine suppressed VPS33B expression by inducing PI3K/AKT/c-Jun-mediated transcription suppression.	Nicotine	26-34	VPS33B late endosome and lysosome associated	Homo sapiens	46-52
31479177-7	2019	Serum bile acid profiles of our VPS33B/VIPAS39 mutated patients revealed similar changes to primary defect of bile salt export pump, among which those with isolated cholestasis phenotype had a higher level of total secondary bile acids than that with typical ARC phenotype, indicating the partial residual function of VPS33B.	Bile Acids and Salts	110-119	VPS33B late endosome and lysosome associated	Homo sapiens	32-38
27319744-5	2016	Tamoxifen-induced, haematopoietic stem cell (HSC)-specific Vps33b deletion completely depleted Vps33b in platelets, caused the absence of alpha-granules, and increased the number of vacuoles in platelets and megakaryocytes.	Tamoxifen	0-9	VPS33B late endosome and lysosome associated	Homo sapiens	59-65
31479177-7	2019	Serum bile acid profiles of our VPS33B/VIPAS39 mutated patients revealed similar changes to primary defect of bile salt export pump, among which those with isolated cholestasis phenotype had a higher level of total secondary bile acids than that with typical ARC phenotype, indicating the partial residual function of VPS33B.	Bile Acids and Salts	225-235	VPS33B late endosome and lysosome associated	Homo sapiens	32-38
30944308-0	2019	VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma.	Fluorouracil	97-111	VPS33B late endosome and lysosome associated	Homo sapiens	0-6
30944308-2	2019	In this research, we demonstrated that overexpression of VPS33B inhibited proliferation and chemoresistance to fluorouracil (5-FU) in nasopharyngeal carcinoma (NPC) in vivo and in vitro.	Fluorouracil	111-123	VPS33B late endosome and lysosome associated	Homo sapiens	57-63
30944308-2	2019	In this research, we demonstrated that overexpression of VPS33B inhibited proliferation and chemoresistance to fluorouracil (5-FU) in nasopharyngeal carcinoma (NPC) in vivo and in vitro.	Fluorouracil	125-129	VPS33B late endosome and lysosome associated	Homo sapiens	57-63
30944308-7	2019	Surprisingly, VPS33B was downregulated in the nicotine-treated and LMP-1-overexpressing NPC cells by targeting PI3K/AKT/c-Jun-mediated signaling.	Nicotine	46-54	VPS33B late endosome and lysosome associated	Homo sapiens	14-20
30944308-9	2019	Our study is the first to demonstrate that VPS33B is negatively regulated by LMP-1 and nicotine and thus suppresses the proliferation of NPC cells by interacting with NESG1 to regulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling in NPC cells.	Nicotine	87-95	VPS33B late endosome and lysosome associated	Homo sapiens	43-49
28017832-7	2017	Additionally, the epidermal ultrastructure of the p.Gly131Glu patients mirrored defects in tamoxifen-inducible VPS33B-deficient Vps33bfl/fl-ERT2 mice.	Tamoxifen	91-100	VPS33B late endosome and lysosome associated	Homo sapiens	111-117
27319744-5	2016	Tamoxifen-induced, haematopoietic stem cell (HSC)-specific Vps33b deletion completely depleted Vps33b in platelets, caused the absence of alpha-granules, and increased the number of vacuoles in platelets and megakaryocytes.	Tamoxifen	0-9	VPS33B late endosome and lysosome associated	Homo sapiens	95-101