PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 30320268-4 2018 A sulfated protein was prepared using a TPST-coupled protein sulfation system that involves the generation of the active sulfate 3"-phosphoadenosine-5"-phosphosulfate (PAPS) through either PAPS synthetase (PAPSS) or phenol sulfotransferase. sulfate 3"-phosphoadenosine-5"-phosphosulfate 121-166 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 189-204 29955124-7 2019 Moreover, PAPSS inhibitor sodium chlorate effectively decreases cell migration induced by Snail and PAPSS2. sodium chlorate 26-41 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 10-15 30320268-4 2018 A sulfated protein was prepared using a TPST-coupled protein sulfation system that involves the generation of the active sulfate 3"-phosphoadenosine-5"-phosphosulfate (PAPS) through either PAPS synthetase (PAPSS) or phenol sulfotransferase. sulfate 3"-phosphoadenosine-5"-phosphosulfate 121-166 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 206-211 30320268-4 2018 A sulfated protein was prepared using a TPST-coupled protein sulfation system that involves the generation of the active sulfate 3"-phosphoadenosine-5"-phosphosulfate (PAPS) through either PAPS synthetase (PAPSS) or phenol sulfotransferase. Phosphoadenosine Phosphosulfate 168-172 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 189-204 28790117-0 2017 In Vivo Validation of PAPSS1 (3"-phosphoadenosine 5"-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target. Cisplatin 85-94 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 22-28 29743239-1 2018 The high-energy sulfate donor 3"-phosphoadenosine-5"-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Sulfates 16-23 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 118-124 29743239-1 2018 The high-energy sulfate donor 3"-phosphoadenosine-5"-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Phosphoadenosine Phosphosulfate 30-67 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 118-124 29743239-1 2018 The high-energy sulfate donor 3"-phosphoadenosine-5"-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Phosphoadenosine Phosphosulfate 69-73 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 118-124 28790117-0 2017 In Vivo Validation of PAPSS1 (3"-phosphoadenosine 5"-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target. Cisplatin 85-94 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 30-78 28790117-4 2017 Finally, the association between PAPSS1 expression levels and survival in patients treated with standard chemotherapy was assessed.Results: Our results show a positive correlation between low PAPSS1 expression and increased cisplatin sensitivity in lung adenocarcinoma. Cisplatin 224-233 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 33-39 28790117-4 2017 Finally, the association between PAPSS1 expression levels and survival in patients treated with standard chemotherapy was assessed.Results: Our results show a positive correlation between low PAPSS1 expression and increased cisplatin sensitivity in lung adenocarcinoma. Cisplatin 224-233 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 192-198 28790117-8 2017 Clinical data suggest that NSCLC and ovarian cancer patients with low PAPSS1 expression survive longer following platinum-based chemotherapy.Conclusions: These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Platinum 113-121 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 70-76 28790117-8 2017 Clinical data suggest that NSCLC and ovarian cancer patients with low PAPSS1 expression survive longer following platinum-based chemotherapy.Conclusions: These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Platinum 113-121 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 181-187 28790117-8 2017 Clinical data suggest that NSCLC and ovarian cancer patients with low PAPSS1 expression survive longer following platinum-based chemotherapy.Conclusions: These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Platinum 113-121 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 181-187 28790117-8 2017 Clinical data suggest that NSCLC and ovarian cancer patients with low PAPSS1 expression survive longer following platinum-based chemotherapy.Conclusions: These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Cisplatin 208-217 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 70-76 28790117-8 2017 Clinical data suggest that NSCLC and ovarian cancer patients with low PAPSS1 expression survive longer following platinum-based chemotherapy.Conclusions: These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Cisplatin 208-217 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 181-187 28790117-8 2017 Clinical data suggest that NSCLC and ovarian cancer patients with low PAPSS1 expression survive longer following platinum-based chemotherapy.Conclusions: These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Cisplatin 208-217 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 181-187 17436279-2 2007 The enzyme 3"-phosphoadenosine 5"-phosphosulfate synthase (PAPSS) catalyzes the biosynthesis of PAPS (3"-phosphoadenosine 5"-phosphosulfate), which serves as the universal sulfate donor compound for all sulfotransferase reactions (Schwartz and Domowicz [2002] Glycobiology 109:143-151). Phosphoadenosine Phosphosulfate 11-48 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 59-64 25948711-10 2015 These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity, presumably to maintain bile acid-conjugating activity. Bile Acids and Salts 178-187 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 39-44 19008949-4 2008 This approach identified a role for 3"-phosphoadenosine 5"-phosphosulfate synthase 1 (PAPSS1), one of two enzymes that synthesize PAPS, the high energy sulfate donor used in all sulfonation reactions catalyzed by cellular sulfotransferases. Sulfates 66-73 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 86-92 17436279-2 2007 The enzyme 3"-phosphoadenosine 5"-phosphosulfate synthase (PAPSS) catalyzes the biosynthesis of PAPS (3"-phosphoadenosine 5"-phosphosulfate), which serves as the universal sulfate donor compound for all sulfotransferase reactions (Schwartz and Domowicz [2002] Glycobiology 109:143-151). Sulfates 41-48 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 59-64 10679223-3 2000 PAPS is synthesized from ATP and inorganic sulfate by PAPS synthetase (PAPSS). Adenosine Triphosphate 25-28 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 54-69 12781330-3 2003 In humans, PAPS is synthesized from ATP and SO(4)(2-) by two isoforms of PAPS synthetase (PAPSS): PAPSS1 and PAPSS2. Adenosine Triphosphate 36-39 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 73-88 12781330-3 2003 In humans, PAPS is synthesized from ATP and SO(4)(2-) by two isoforms of PAPS synthetase (PAPSS): PAPSS1 and PAPSS2. Adenosine Triphosphate 36-39 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 90-95 12781330-3 2003 In humans, PAPS is synthesized from ATP and SO(4)(2-) by two isoforms of PAPS synthetase (PAPSS): PAPSS1 and PAPSS2. Adenosine Triphosphate 36-39 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 98-104 12781330-13 2003 These observations represent a step toward testing the hypothesis that genetic variation in PAPS synthesis catalyzed by PAPSS1 might alter in vivo sulfate conjugation. Sulfates 147-154 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 120-126 11773860-3 2002 In humans, PAPS is synthesized from adenosine 5"-triphosphate (ATP) and inorganic sulfate (SO2-4) by two isoforms, PAPSS1 and PAPSS2. Sulfates 72-89 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 115-121 11773860-3 2002 In humans, PAPS is synthesized from adenosine 5"-triphosphate (ATP) and inorganic sulfate (SO2-4) by two isoforms, PAPSS1 and PAPSS2. so2-4 91-96 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 115-121 11159808-3 2001 The synthesis of PAPS from inorganic sulfate and ATP is catalyzed by PAPS synthetase (PAPSS). Phosphoadenosine Phosphosulfate 17-21 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 69-84 11159808-3 2001 The synthesis of PAPS from inorganic sulfate and ATP is catalyzed by PAPS synthetase (PAPSS). Phosphoadenosine Phosphosulfate 17-21 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 86-91 11159808-3 2001 The synthesis of PAPS from inorganic sulfate and ATP is catalyzed by PAPS synthetase (PAPSS). Sulfates 27-44 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 69-84 11159808-3 2001 The synthesis of PAPS from inorganic sulfate and ATP is catalyzed by PAPS synthetase (PAPSS). Sulfates 27-44 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 86-91 11159808-3 2001 The synthesis of PAPS from inorganic sulfate and ATP is catalyzed by PAPS synthetase (PAPSS). Adenosine Triphosphate 49-52 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 69-84 11159808-3 2001 The synthesis of PAPS from inorganic sulfate and ATP is catalyzed by PAPS synthetase (PAPSS). Adenosine Triphosphate 49-52 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 86-91 11159808-6 2001 This coupled assay uses the sulfation of 17beta-[(3)H]estradiol catalyzed by recombinant human SULT1E1 to measure PAPS, which has been generated by PAPSS during the initial step of the assay. 17beta-[(3)h]estradiol 41-63 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 148-153 11159808-7 2001 SULT1E1 proved to be ideal for this application both because of its relative resistance to inhibition by ATP, a substrate for the PAPSS-catalyzed step, and because of its low K(m) values for both PAPS (58 nM) and estradiol (29 nM). Adenosine Triphosphate 105-108 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 130-135 11159808-9 2001 Brain and liver cytosol PAPSS activities had apparent K(m) values for ATP of 0.26 and 0.62 mM, respectively, and for SO(4)(2-) of 0.08 and 0.31 mM, respectively. Adenosine Triphosphate 70-73 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 24-29 17276460-1 2007 Bifunctional human PAPS synthetase (PAPSS) catalyzes, in a two-step process, the formation of the activated sulfate carrier 3"-phosphoadenosine 5"-phosphosulfate (PAPS). Sulfates 108-115 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 19-34 17276460-1 2007 Bifunctional human PAPS synthetase (PAPSS) catalyzes, in a two-step process, the formation of the activated sulfate carrier 3"-phosphoadenosine 5"-phosphosulfate (PAPS). Sulfates 108-115 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 36-41 17276460-1 2007 Bifunctional human PAPS synthetase (PAPSS) catalyzes, in a two-step process, the formation of the activated sulfate carrier 3"-phosphoadenosine 5"-phosphosulfate (PAPS). Phosphoadenosine Phosphosulfate 124-161 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 19-34 17276460-1 2007 Bifunctional human PAPS synthetase (PAPSS) catalyzes, in a two-step process, the formation of the activated sulfate carrier 3"-phosphoadenosine 5"-phosphosulfate (PAPS). Phosphoadenosine Phosphosulfate 124-161 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 36-41 17276460-1 2007 Bifunctional human PAPS synthetase (PAPSS) catalyzes, in a two-step process, the formation of the activated sulfate carrier 3"-phosphoadenosine 5"-phosphosulfate (PAPS). Phosphoadenosine Phosphosulfate 19-23 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 36-41 17276460-11 2007 We report the structure of the APS-kinase domain of human PAPSS1 in complex with two APS molecules, demonstrating the ability of the ATP/ADP-binding site to bind APS. aps 31-34 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 58-64 17276460-11 2007 We report the structure of the APS-kinase domain of human PAPSS1 in complex with two APS molecules, demonstrating the ability of the ATP/ADP-binding site to bind APS. Adenosine Triphosphate 133-136 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 58-64 17276460-11 2007 We report the structure of the APS-kinase domain of human PAPSS1 in complex with two APS molecules, demonstrating the ability of the ATP/ADP-binding site to bind APS. Adenosine Diphosphate 137-140 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 58-64 12716056-1 2003 3"-phosphoadenosine 5"-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. sulfonate 127-136 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 55-60 10679223-3 2000 PAPS is synthesized from ATP and inorganic sulfate by PAPS synthetase (PAPSS). Adenosine Triphosphate 25-28 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 71-76 10679223-3 2000 PAPS is synthesized from ATP and inorganic sulfate by PAPS synthetase (PAPSS). Sulfates 33-50 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 54-69 10679223-3 2000 PAPS is synthesized from ATP and inorganic sulfate by PAPS synthetase (PAPSS). Sulfates 33-50 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 71-76 10657990-0 2000 Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells. Sulfates 45-52 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 24-41 10657990-2 2000 While sulfate activation has long been assumed to occur in the cytosol, we show in this study that human PAPS synthetase 1 (PAPSS1), a bifunctional ATP sulfurylase/adenosine 5"-phosphosulfate (APS) kinase enzyme sufficient for PAPS synthesis, accumulates in the nucleus of mammalian cells. Sulfates 6-13 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 105-122 10657990-2 2000 While sulfate activation has long been assumed to occur in the cytosol, we show in this study that human PAPS synthetase 1 (PAPSS1), a bifunctional ATP sulfurylase/adenosine 5"-phosphosulfate (APS) kinase enzyme sufficient for PAPS synthesis, accumulates in the nucleus of mammalian cells. Sulfates 6-13 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 124-130 10657990-4 2000 Human PAPSS1 and Drosophila melanogaster PAPSS localize to the nucleus in yeast and relieve the methionine auxotrophy of ATP sulfurylase- or APS kinase-deficient strains, suggesting that PAPSS1 is fully functional in vivo when targeted to the nucleus. Methionine 96-106 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 6-12 10657990-4 2000 Human PAPSS1 and Drosophila melanogaster PAPSS localize to the nucleus in yeast and relieve the methionine auxotrophy of ATP sulfurylase- or APS kinase-deficient strains, suggesting that PAPSS1 is fully functional in vivo when targeted to the nucleus. Methionine 96-106 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 187-193 10657990-8 2000 -Besset, S., Vincourt, J.-B., Amalric, F., Girard, J.-P. Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells. Sulfates 102-109 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 81-98 31659234-4 2020 Previously, we showed pure culture SRM adaptation to perchlorate stress through mutation of the sulfate adenylyltransferase, a central enzyme in the sulfate reduction pathway. perchlorate 53-64 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 96-123 34818583-2 2022 Human PAPS synthases (PAPSS1 and 2) are the only enzymes that catalyze PAPS production from inorganic sulfate. Sulfates 92-109 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 22-34 9668121-5 1998 The 1-268 fragment demonstrated Michaelis-Menten kinetics against ATP as substrate (Km 0.26 mM); however, full-length hPAPSS exhibited a sigmoidal response (apparent Km 1.5 mM) suggesting cooperative binding. Adenosine Triphosphate 66-69 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 118-124 9668121-6 1998 Catalytic efficiency (Vmax/Km) of the 1-268 fragment was 64-fold higher than full-length hPAPSS for ATP. Adenosine Triphosphate 100-103 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 89-95 9668121-9 1998 Purified full-length hPAPSS, in contrast to the COS-1 cell-expressed cDNA construct, exhibited a hyperbolic response curve against ATP suggesting that hPAPSS is perhaps modified in vivo. Adenosine Triphosphate 131-134 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 21-27 34712849-0 2021 Role of aspartic acid residues D87 and D89 in APS kinase domain of human 3"-phosphoadenosine 5"-phosphosulfate synthase 1 and 2b: A commonality with phosphatases/kinases. Aspartic Acid 8-21 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 73-128 34712849-1 2021 3"-phosphoadenosine 5"-phosphosulfate (PAPS) is synthesized in two steps by PAPS synthase (PAPSS). 3"-phosphoadenosine 5"-phosphosulfate 0-37 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 76-89 34712849-1 2021 3"-phosphoadenosine 5"-phosphosulfate (PAPS) is synthesized in two steps by PAPS synthase (PAPSS). 3"-phosphoadenosine 5"-phosphosulfate 0-37 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 91-96 34712849-1 2021 3"-phosphoadenosine 5"-phosphosulfate (PAPS) is synthesized in two steps by PAPS synthase (PAPSS). PAPS 39-43 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 76-89 34712849-1 2021 3"-phosphoadenosine 5"-phosphosulfate (PAPS) is synthesized in two steps by PAPS synthase (PAPSS). PAPS 39-43 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 91-96 34712849-7 2021 PAPSS is an, unique enzyme that binds to four different nucleotides: ATP and APS on both ATPS and APSK domains and ADP and PAPS exclusively on the APSK domain. Adenosine Triphosphate 69-72 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 0-5 34712849-7 2021 PAPSS is an, unique enzyme that binds to four different nucleotides: ATP and APS on both ATPS and APSK domains and ADP and PAPS exclusively on the APSK domain. Adenosine Phosphosulfate 77-80 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 0-5 34712849-7 2021 PAPSS is an, unique enzyme that binds to four different nucleotides: ATP and APS on both ATPS and APSK domains and ADP and PAPS exclusively on the APSK domain. Adenosine Diphosphate 115-118 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 0-5 34712849-13 2021 In addition, gamma32P-ATP, trapped phosphoryl enzyme intermediate more with PAPSS2 than with PAPSS1. gamma32p-atp 13-25 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 93-99