PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31673852-0	2019	Production of 5-aminolevulinic acid from glutamate by overexpressing HemA1 and pgr7 from Arabidopsis thaliana in Escherichia coli.	5-amino levulinic acid	14-35	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	69-74
31673852-0	2019	Production of 5-aminolevulinic acid from glutamate by overexpressing HemA1 and pgr7 from Arabidopsis thaliana in Escherichia coli.	Glutamic Acid	41-50	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	69-74
31673852-2	2019	In this study, we introduced the HemA1 and pgr7 genes from the higher plant Arabidopsis thaliana into recombinant Escherichia coli to overproduce extracellular 5-aminolevulinic acid via the C5 pathway.	5-amino levulinic acid	160-181	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	33-38
31673852-3	2019	In the E. coli BL21 (DE3) strain background, the ALA concentration of the strain expressing both HemA1 and pgr7 was the highest and reached 3080.62 mg/L.	5-amino levulinic acid	49-52	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	97-102
31673852-7	2019	The recombinant E. coli Transetta GTR/GBP was able to produce 7642 mg/L ALA in modified minimal medium supplemented with 10 g/L glutamate and 15 g/L glucose after 48 h of fermentation at 22  C. The results provide persuading evidence for the efficient production of ALA from glucose and glutamate in E. coli expressing A. thaliana HemA1 and pgr7.	5-amino levulinic acid	72-75	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	331-336
23888164-6	2013	A sophisticated response comprising the down-regulation of HEMA1 and NYC1, which catalyze the first committed step in tetrapyrrole biosynthesis and the conversion of Chl b to Chl a at the commencement of Chl breakdown, respectively, and the up-regulation of CGLD27, which is conserved in plastid-containing organisms and putatively involved in xanthophyll biosynthesis, indicates a carefully orchestrated balance of potentially toxic tetrapyrrole intermediates and functional end products to avoid photo-oxidative damage.	Tetrapyrroles	118-130	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	59-64
25706562-5	2015	In the pale-green leaves of the atl31/atl6, the expression of HEMA1, which encodes the key enzyme for 5-aminolevulinic acid synthesis, the rate-limiting step in chlorophyll biosynthesis, was markedly down-regulated.	5-amino levulinic acid	102-123	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	62-67
25706562-5	2015	In the pale-green leaves of the atl31/atl6, the expression of HEMA1, which encodes the key enzyme for 5-aminolevulinic acid synthesis, the rate-limiting step in chlorophyll biosynthesis, was markedly down-regulated.	Chlorophyll	161-172	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	62-67
24449654-1	2014	Arabidopsis HEMA1 and HEMA2 encode glutamyl-tRNA reductase (GluTR) 1 and 2, the two isoforms of the initial enzyme of tetrapyrrole biosynthesis.	Tetrapyrroles	118-130	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	12-17
24449654-4	2014	While hema1 accumulates low amounts of Chl, it contains more than half of the wild-type heme content.	Heme	88-92	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	6-11
27388681-5	2016	This effect of cytokinin on metabolite levels arises due to the modulation of expression for chlorophyll biosynthesis genes such as HEMA1, GUN4, GUN5, and CHLM Increased expression of HEMA1 is reflected in an enhanced level of the encoded glutamyl-tRNA reductase, which catalyzes one of the rate-limiting steps of chlorophyll biosynthesis.	Chlorophyll	93-104	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	132-137
27388681-5	2016	This effect of cytokinin on metabolite levels arises due to the modulation of expression for chlorophyll biosynthesis genes such as HEMA1, GUN4, GUN5, and CHLM Increased expression of HEMA1 is reflected in an enhanced level of the encoded glutamyl-tRNA reductase, which catalyzes one of the rate-limiting steps of chlorophyll biosynthesis.	Chlorophyll	93-104	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	184-189
27388681-5	2016	This effect of cytokinin on metabolite levels arises due to the modulation of expression for chlorophyll biosynthesis genes such as HEMA1, GUN4, GUN5, and CHLM Increased expression of HEMA1 is reflected in an enhanced level of the encoded glutamyl-tRNA reductase, which catalyzes one of the rate-limiting steps of chlorophyll biosynthesis.	Chlorophyll	314-325	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	132-137
27388681-5	2016	This effect of cytokinin on metabolite levels arises due to the modulation of expression for chlorophyll biosynthesis genes such as HEMA1, GUN4, GUN5, and CHLM Increased expression of HEMA1 is reflected in an enhanced level of the encoded glutamyl-tRNA reductase, which catalyzes one of the rate-limiting steps of chlorophyll biosynthesis.	Chlorophyll	314-325	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	184-189
27388681-8	2016	B-type ARRs bind to the promotors of HEMA1 and LHCB6 genes, indicating that cytokinin-dependent transcription factors directly regulate genes of chlorophyll biosynthesis and the light harvesting complex.	Chlorophyll	145-156	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	37-42
25840087-5	2015	In addition, a mutation in either HEMA1 or GSA1, two other enzymes for 5-ALA synthesis, also suppressed ssadh fully and partially, respectively.	5-amino levulinic acid	71-76	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	34-39
23888164-6	2013	A sophisticated response comprising the down-regulation of HEMA1 and NYC1, which catalyze the first committed step in tetrapyrrole biosynthesis and the conversion of Chl b to Chl a at the commencement of Chl breakdown, respectively, and the up-regulation of CGLD27, which is conserved in plastid-containing organisms and putatively involved in xanthophyll biosynthesis, indicates a carefully orchestrated balance of potentially toxic tetrapyrrole intermediates and functional end products to avoid photo-oxidative damage.	Tetrapyrroles	434-446	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	59-64
15584960-0	2004	Concurrent interactions of heme and FLU with Glu tRNA reductase (HEMA1), the target of metabolic feedback inhibition of tetrapyrrole biosynthesis, in dark- and light-grown Arabidopsis plants.	Heme	27-31	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	65-70
22102866-7	2011	Altering GNC and CGA1 expression was also found to modulate the expression of important chlorophyll biosynthesis genes (GUN4, HEMA1, PORB, and PORC).	Chlorophyll	88-99	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	126-131
21272955-3	2011	Induced inactivation of the HEMA1 gene encoding GluTR by RNAi expression in tobacco resulted in a reduced activity of Mg chelatase and Fe chelatase indicating a feed-forward regulatory mechanism that links ALA synthesis posttranslationally with late enzymes of tetrapyrrole biosynthesis (Hedtke et al., 2007).	5-amino levulinic acid	206-209	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	28-33
21272955-3	2011	Induced inactivation of the HEMA1 gene encoding GluTR by RNAi expression in tobacco resulted in a reduced activity of Mg chelatase and Fe chelatase indicating a feed-forward regulatory mechanism that links ALA synthesis posttranslationally with late enzymes of tetrapyrrole biosynthesis (Hedtke et al., 2007).	Tetrapyrroles	261-273	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	28-33
21272955-6	2011	While constitutive AtHEMA1 overexpression in tobacco stimulates ALA synthesis by 50-90% during light-exposed growth of seedlings, no increase in heme and chlorophyll contents is observed.	5-amino levulinic acid	64-67	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	19-26
21272955-7	2011	HEMA1 overexpression in etiolated and dark-grown Arabidopsis and tobacco seedlings leads to additional accumulation of protochlorophyllide.	Protochlorophyllide	119-138	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	0-5
20510016-0	2010	Expression of yeast Hem1 gene controlled by Arabidopsis HemA1 promoter improves salt tolerance in Arabidopsis plants.	Salts	80-84	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	56-61
15584960-0	2004	Concurrent interactions of heme and FLU with Glu tRNA reductase (HEMA1), the target of metabolic feedback inhibition of tetrapyrrole biosynthesis, in dark- and light-grown Arabidopsis plants.	Tetrapyrroles	120-132	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	65-70
12139011-11	2002	The roles of HEMA1 and HEMA2 in meeting cellular tetrapyrrole requirements are discussed.	Tetrapyrroles	49-61	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	13-18
12445126-2	2002	To understand how this co-ordination is achieved, we have made a detailed study of the light-regulated signalling pathways mediating the expression of the HEMA1 and Lhcb genes encoding glutamyl-tRNA reductase, the first committed enzyme of 5-aminolaevulinic acid formation, and chlorophyll a/b-binding proteins, respectively.	Aminolevulinic Acid	240-262	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	155-160
12139011-8	2002	In addition, elimination of a promotive plastid signal by Norflurazon-induced photobleaching of plastids had no effect on HEMA2 expression while being required for normal white-light induction of HEMA1.	norflurazone	58-69	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	196-201
12139011-10	2002	HEMA1 expression in cotyledons is also inhibited by sugars, but in a strictly light-dependent manner.	Sugars	52-58	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	0-5
12226519-1	2002	We have examined the expression of the HEMA1 gene, which encodes the key chlorophyll synthesis enzyme glutamyl-tRNA reductase, during the phytochrome A-mediated far-red light (FR) block of greening response in Arabidopsis.	Chlorophyll	73-84	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	39-44
11309145-9	2001	These results provide the most comprehensive analysis to date of the light-regulation of a tetrapyrrole biosynthetic gene and support a direct link between regulation of HEMA1 transcription and chlorophyll accumulation during seedling de-etiolation.	Tetrapyrroles	91-103	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	170-175
11309145-9	2001	These results provide the most comprehensive analysis to date of the light-regulation of a tetrapyrrole biosynthetic gene and support a direct link between regulation of HEMA1 transcription and chlorophyll accumulation during seedling de-etiolation.	Chlorophyll	194-205	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	170-175
10631248-0	2000	Antisense HEMA1 RNA expression inhibits heme and chlorophyll biosynthesis in arabidopsis.	Heme	40-44	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	10-15
10631248-0	2000	Antisense HEMA1 RNA expression inhibits heme and chlorophyll biosynthesis in arabidopsis.	Chlorophyll	49-60	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	10-15