PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32046144-6	2020	MC-LR also induced significant upregulation of downstream lipid metabolism-related factors and genes including srebf1, srebf2, fatty acid synthase (fasn), acetyl-CoA carboxylase (acaca), stearoyl-CoA desaturase (scd), HMG CoA reductase (hmgcra), and HMG CoA synthase (hmgcs1), and downregulation of genes associated with lipolysis such as triglyceride hydrolase gene (atgl), hormone-sensitive enzyme gene (hsla), and carnitine palmitoyltransferase gene (cpt1aa).	cyanoginosin LR	0-5	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	268-274
35331265-12	2022	Furthermore, the expression levels of critical genes involved in ER stress (atf6, irela, bip, chop) and the key enzymes regulating lipid metabolism (acc1, fasn, hmgcs1 and hmgcra) were significantly higher in the alcohol-treated group than in the control group.	Alcohols	213-220	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	161-167
30987969-0	2019	Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development.	Terpenes	67-78	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	27-33
30987969-6	2019	hmgcs1 encodes the first enzyme in the cholesterol synthesis pathway and mutation of hmgcs1 inhibits cholesterol synthesis.	Cholesterol	39-50	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	0-6
30987969-6	2019	hmgcs1 encodes the first enzyme in the cholesterol synthesis pathway and mutation of hmgcs1 inhibits cholesterol synthesis.	Cholesterol	101-112	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	0-6
30987969-6	2019	hmgcs1 encodes the first enzyme in the cholesterol synthesis pathway and mutation of hmgcs1 inhibits cholesterol synthesis.	Cholesterol	101-112	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	85-91
24573296-4	2014	Through a forward genetic screen in zebrafish we discovered that mutation of hmgcs1, which encodes an enzyme necessary for isoprenoid and cholesterol synthesis, causes oligodendrocyte progenitor cells (OPCs) to migrate past their target axons and to fail to express myelin genes.	Terpenes	123-133	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	77-83
28686747-0	2017	Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development.	Cholesterol	90-101	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	49-55
28686747-0	2017	Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development.	Terpenes	106-117	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	49-55
28686747-7	2017	Our analysis confirmed that mutation of hmgcs1, which encodes the first enzyme in the cholesterol synthesis pathway, results in craniofacial abnormalities via defects in cranial neural crest cell differentiation.	Cholesterol	86-97	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	40-46
24573296-4	2014	Through a forward genetic screen in zebrafish we discovered that mutation of hmgcs1, which encodes an enzyme necessary for isoprenoid and cholesterol synthesis, causes oligodendrocyte progenitor cells (OPCs) to migrate past their target axons and to fail to express myelin genes.	Cholesterol	138-149	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Danio rerio	77-83