PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34856328-0	2021	Up-regulation of VSIG4 alleviates kidney transplantation-associated acute kidney injury through suppressing inflammation and ROS via regulation of AKT signaling.	Reactive Oxygen Species	125-128	V-set and immunoglobulin domain containing 4	Mus musculus	17-22
19833734-5	2009	Using the crystal structure of CRIg in complex with C3b as a guide for library design, we isolated a CRIg-ECD double mutant (Q64R/M86Y, CRIg-v27) that showed increased binding affinity and improved complement inhibitory activity relative to CRIg-ECD.	1-D-glucopyranosyl cytosine	52-55	V-set and immunoglobulin domain containing 4	Mus musculus	31-35
19833734-5	2009	Using the crystal structure of CRIg in complex with C3b as a guide for library design, we isolated a CRIg-ECD double mutant (Q64R/M86Y, CRIg-v27) that showed increased binding affinity and improved complement inhibitory activity relative to CRIg-ECD.	1-D-glucopyranosyl cytosine	52-55	V-set and immunoglobulin domain containing 4	Mus musculus	101-109
19833734-5	2009	Using the crystal structure of CRIg in complex with C3b as a guide for library design, we isolated a CRIg-ECD double mutant (Q64R/M86Y, CRIg-v27) that showed increased binding affinity and improved complement inhibitory activity relative to CRIg-ECD.	1-D-glucopyranosyl cytosine	52-55	V-set and immunoglobulin domain containing 4	Mus musculus	101-105
19833734-5	2009	Using the crystal structure of CRIg in complex with C3b as a guide for library design, we isolated a CRIg-ECD double mutant (Q64R/M86Y, CRIg-v27) that showed increased binding affinity and improved complement inhibitory activity relative to CRIg-ECD.	1-D-glucopyranosyl cytosine	52-55	V-set and immunoglobulin domain containing 4	Mus musculus	241-249
34856328-7	2021	Oxidative stress and reactive oxygen species (ROS) accumulation in renal tissues were also mitigated by exogenous VSIG4 in CI/KT mice through improving nuclear factor-erythroid 2 related factor 2 (Nrf2) nuclear expression.	Reactive Oxygen Species	21-44	V-set and immunoglobulin domain containing 4	Mus musculus	114-119
34856328-7	2021	Oxidative stress and reactive oxygen species (ROS) accumulation in renal tissues were also mitigated by exogenous VSIG4 in CI/KT mice through improving nuclear factor-erythroid 2 related factor 2 (Nrf2) nuclear expression.	Reactive Oxygen Species	46-49	V-set and immunoglobulin domain containing 4	Mus musculus	114-119
34856328-8	2021	The inhibitory effects of VSIG4 on inflammation, ROS generation and cell death were confirmed in OGD/R-treated macrophages, which further ameliorated oxidative damage and apoptosis in podocytes.	Reactive Oxygen Species	49-52	V-set and immunoglobulin domain containing 4	Mus musculus	26-31
35112881-8	2022	In lean CRIg-/- or C3-/- (complement component 3) mice intravenously injected with gut mEVs, adrenal microbial DNA accumulation elevated adrenal inflammation and norepinephrine secretion, concomitant with hypertension.	Norepinephrine	162-176	V-set and immunoglobulin domain containing 4	Mus musculus	8-12
34433706-0	2021	VISTA stimulation of VSIG4-positive macrophages strongly suppresses T cell proliferation via excessive nitric oxide production in sepsis.	fluquinconazole	0-5	V-set and immunoglobulin domain containing 4	Mus musculus	21-26
34433706-0	2021	VISTA stimulation of VSIG4-positive macrophages strongly suppresses T cell proliferation via excessive nitric oxide production in sepsis.	Nitric Oxide	103-115	V-set and immunoglobulin domain containing 4	Mus musculus	21-26
34433706-6	2021	When cocultured with splenic T cells, VSIG4(+) cells inhibited the proliferation of activated T cells through the release of nitric oxide compared to VSIG4(-) cells.	Nitric Oxide	125-137	V-set and immunoglobulin domain containing 4	Mus musculus	38-43
34433706-7	2021	Stimulation of VSIG4(+) cells with VISTA antibody increased the expression of several cytokine genes and the release of nitric oxide, but not phagocytosis, compared to those of hamster IgG-stimulated VSIG4(+) cells.	Nitric Oxide	120-132	V-set and immunoglobulin domain containing 4	Mus musculus	15-20
34433706-8	2021	When cocultured with splenic T cells, VISTA-stimulated VSIG4(+) cells induced excessive T cell suppression via more NO secretion compared to hamster IgG-stimulated VSIG4(+) cells.	fluquinconazole	38-43	V-set and immunoglobulin domain containing 4	Mus musculus	55-60
35013905-12	2022	Ad-VSIG4 attenuated NLRP3 levels and inhibited inflammation, as well as improved neurological function and reduced BBB disruption and brain water content.	Water	140-145	V-set and immunoglobulin domain containing 4	Mus musculus	3-8
31752725-10	2019	Serum creatinine and BUN levels in MRL/lpr mice was maintained in highest CRIg/FH dose (10 mg/kg twice a week) to be significantly lower than that in prednisone treated MRL/lpr mice at 20 weeks age.	Creatinine	6-16	V-set and immunoglobulin domain containing 4	Mus musculus	74-78
31784084-12	2020	In vitro, the neuron-glial mixed culture by fluorescent staining showed that oxygen glucose deprivation (OGD) treatment led to significant cell death, while being attenuated by Vsig4 over-expression in primary microglial cells.	Oxygen	77-83	V-set and immunoglobulin domain containing 4	Mus musculus	177-182
29525783-0	2018	Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80+Clec4f+Vsig4+Ly6C- Kupffer Cell Subsets.	Cholesterol Esters	26-43	V-set and immunoglobulin domain containing 4	Mus musculus	88-93
31288389-2	2019	Here, we further addressed the specificity and assessed the potential for arthritis monitoring using near-infrared fluorescence (NIRF) Cy7-labeled Vsig4 nanobody (Cy7-Nb119).	cyanine dye 7	135-138	V-set and immunoglobulin domain containing 4	Mus musculus	147-152
30662948-5	2019	Exaggerated NLRP3 and IL-1beta expression in Vsig4-/- mice is accountable for deleterious disease severity in experimental autoimmune encephalomyelitis (EAE) and resistance to dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	176-198	V-set and immunoglobulin domain containing 4	Mus musculus	45-50
30662948-5	2019	Exaggerated NLRP3 and IL-1beta expression in Vsig4-/- mice is accountable for deleterious disease severity in experimental autoimmune encephalomyelitis (EAE) and resistance to dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	200-203	V-set and immunoglobulin domain containing 4	Mus musculus	45-50
30429287-8	2018	The specific PI3K antagonist duvelisib almost completely abrogated AKT phosphorylation, thus abolishing the renoprotective role of CRIg/FH.	duvelisib	29-38	V-set and immunoglobulin domain containing 4	Mus musculus	131-135
29525783-7	2018	After ablation hepatic macrophages via injection with liposomal clodronate, the reappearance of hepatic gene and protein expression of CETP coincided with Clec4f and Vsig4, but not Ly6C.	Clodronic Acid	64-74	V-set and immunoglobulin domain containing 4	Mus musculus	166-171
25929804-4	2015	2,4,6-Trinitrophenyl hapten (TNP) - Keyhole Limpet Hemocyanin (KLH)-primed B cells cocultured with OVA-primed CD4(+) T cells from OVA-immunized VSIG4 KO mice in the presence of TNP-OVA showed enhanced isotype switching to IgG subclasses compared to those cocultured with cells isolated from OVA-immunized wild-type (WT) mice.	2,4,6-trinitrophenyl hapten	0-27	V-set and immunoglobulin domain containing 4	Mus musculus	144-149
29109438-4	2017	VSIG4 activates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive oxygen species secretion, and macrophage inhibition.	Pyruvic Acid	55-63	V-set and immunoglobulin domain containing 4	Mus musculus	0-5
29109438-4	2017	VSIG4 activates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive oxygen species secretion, and macrophage inhibition.	Acetyl Coenzyme A	204-214	V-set and immunoglobulin domain containing 4	Mus musculus	0-5
29109438-4	2017	VSIG4 activates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive oxygen species secretion, and macrophage inhibition.	Reactive Oxygen Species	241-264	V-set and immunoglobulin domain containing 4	Mus musculus	0-5
29109438-6	2017	Forced expression of Vsig4 in mice ameliorates MHV-3-induced viral fulminant hepatitis.	mhv-3	47-52	V-set and immunoglobulin domain containing 4	Mus musculus	21-26
25929804-4	2015	2,4,6-Trinitrophenyl hapten (TNP) - Keyhole Limpet Hemocyanin (KLH)-primed B cells cocultured with OVA-primed CD4(+) T cells from OVA-immunized VSIG4 KO mice in the presence of TNP-OVA showed enhanced isotype switching to IgG subclasses compared to those cocultured with cells isolated from OVA-immunized wild-type (WT) mice.	IP3K Inhibitor	29-32	V-set and immunoglobulin domain containing 4	Mus musculus	144-149
24686780-9	2014	SPECT/CT imaging revealed that (99m)Tc-NbV4m119 specifically targeted CRIg-positive liver macrophages in naive wild-type but not in CRIg(-/-) (CRIg knockout) mice.	tc-nbv4m119	36-47	V-set and immunoglobulin domain containing 4	Mus musculus	70-74
21768202-6	2012	On the other hand, intestinal Mphi from 2,4,6-trinitrobenzene sulfonic acid-treated mice had decreased CRIg expression but increased CD11b expression, implying some contribution to the removal of immune complexes.	Trinitrobenzenesulfonic Acid	40-75	V-set and immunoglobulin domain containing 4	Mus musculus	103-107
20806290-6	2010	Treatment with CRIg-Fc also led to reduced T-cell proliferation and IFN-gamma, TNF-alpha, IL-17, and IL-6 cytokine production by T cells, and reduced nitric oxide production in BM-derived macrophages.	Nitric Oxide	150-162	V-set and immunoglobulin domain containing 4	Mus musculus	15-19
20806290-8	2010	CRIg-Fc suppressed retinal inflammation in EAU by blocking AP-mediated complement activation with probable direct effects on C3/C5 activation of macrophages, thus leading to reduced nitric oxide production by infiltrating CRIg(-) macrophages.	Nitric Oxide	182-194	V-set and immunoglobulin domain containing 4	Mus musculus	0-4
22711680-7	2012	Administration of soluble VSIG4.Ig to wildtype mice prevented CIH development and prolonged the survival of mice with established CIH.	cih	62-65	V-set and immunoglobulin domain containing 4	Mus musculus	26-31
22711680-7	2012	Administration of soluble VSIG4.Ig to wildtype mice prevented CIH development and prolonged the survival of mice with established CIH.	cih	130-133	V-set and immunoglobulin domain containing 4	Mus musculus	26-31