PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
7504453-6	1993	Within the context of the microvasculature alpha-smooth muscle actin and the HMW-MAA chondroitin sulphate proteoglycan are useful markers for pericytes.	Chondroitin Sulfates	85-105	chondroitin sulfate proteoglycan 4	Homo sapiens	77-84
8275478-7	1994	This temporal relationship suggests but does not prove that the anti-HMW-MAA immunity elicited by anti-id mAb MK2-23 has a beneficial effect on the clinical course of the disease in patients with malignant melanoma.	mk2-23	110-116	chondroitin sulfate proteoglycan 4	Homo sapiens	69-76
8244345-2	1993	Although no genetic diseases of connective tissue map to this location, the malignant melanoma-associated surface antigen mel-CSPG is located here; mel-CSPG is a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	162-181	chondroitin sulfate proteoglycan 4	Homo sapiens	122-130
8244345-2	1993	Although no genetic diseases of connective tissue map to this location, the malignant melanoma-associated surface antigen mel-CSPG is located here; mel-CSPG is a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	162-181	chondroitin sulfate proteoglycan 4	Homo sapiens	148-156
8416734-2	1993	Administration with an adjuvant of mAb MK2-23 conjugated to a carrier has been shown to induce anti-HMW-MAA antibodies both in syngeneic hosts and in patients with malignant melanoma.	mk2-23	39-45	chondroitin sulfate proteoglycan 4	Homo sapiens	100-107
7686858-3	1993	Serological and immunochemical assays showed that the anti-anti-idiotypic (anti-anti-id) mAb GH827, GH1002 and GH1081 react only with the immunizing anti-id mAb MK2-23 and that the anti-anti-id mAb GH149, GH368, GH464, GH518, GH586, GH704, GH786 and GH1151 react with both mAb MK2-23 and HMW-MAA.	gh827	93-98	chondroitin sulfate proteoglycan 4	Homo sapiens	288-295
7686858-3	1993	Serological and immunochemical assays showed that the anti-anti-idiotypic (anti-anti-id) mAb GH827, GH1002 and GH1081 react only with the immunizing anti-id mAb MK2-23 and that the anti-anti-id mAb GH149, GH368, GH464, GH518, GH586, GH704, GH786 and GH1151 react with both mAb MK2-23 and HMW-MAA.	gh1081	111-117	chondroitin sulfate proteoglycan 4	Homo sapiens	288-295
1731316-0	1992	Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma.	mk2-23	118-124	chondroitin sulfate proteoglycan 4	Homo sapiens	6-55
1387883-5	1992	Functional studies revealed that the CTL 49 clone lysed all the HMW-MAA+ tumor lines in the presence of bsmAbs and that these reagents affected the target lysis in a cooperative fashion.	Antibodies, Bispecific	104-110	chondroitin sulfate proteoglycan 4	Homo sapiens	64-71
1731316-0	1992	Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma.	mk2-23	118-124	chondroitin sulfate proteoglycan 4	Homo sapiens	57-64
1731316-0	1992	Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma.	mk2-23	118-124	chondroitin sulfate proteoglycan 4	Homo sapiens	152-159
1760821-0	1991	Regression of human melanoma xenografts in nude mice injected with methotrexate linked to monoclonal antibody 225.28 to human high molecular weight-melanoma associated antigen.	Methotrexate	67-79	chondroitin sulfate proteoglycan 4	Homo sapiens	126-175
1409413-0	1992	Association between induction of anti high molecular weight-melanoma associated antigen (HMW-MAA) immunity with mouse antiidiotypic monoclonal antibody (MoAb) MK2-23 and prolongation of survival in patients with melanoma.	mk2-23	159-165	chondroitin sulfate proteoglycan 4	Homo sapiens	38-87
1409413-0	1992	Association between induction of anti high molecular weight-melanoma associated antigen (HMW-MAA) immunity with mouse antiidiotypic monoclonal antibody (MoAb) MK2-23 and prolongation of survival in patients with melanoma.	mk2-23	159-165	chondroitin sulfate proteoglycan 4	Homo sapiens	89-96
1934623-3	1991	IMelpgl represents an idiotypic mimic of the high-molecular-weight melanoma-associated antigen, HMW-MAA.	imelpgl	0-7	chondroitin sulfate proteoglycan 4	Homo sapiens	96-103
34883035-9	2022	In ex vivo skin permeation, nanoemulgel (NG2) showed increased penetration and localized accumulation of methoxsalen across the skin compared with plain gel.	Methoxsalen	105-116	chondroitin sulfate proteoglycan 4	Homo sapiens	41-44
34942534-0	2022	Chondroitin sulfate proteoglycan 4, a targetable oncoantigen that promotes ovarian cancer growth, invasion, cisplatin resistance and spheroid formation.	Cisplatin	108-117	chondroitin sulfate proteoglycan 4	Homo sapiens	0-34
34942534-5	2022	Our results show that CSPG4 promotes EOC cell invasion, cisplatin resistance and spheroid formation in vitro and tumor expansion in vivo.	Cisplatin	56-65	chondroitin sulfate proteoglycan 4	Homo sapiens	22-27
2273574-3	1990	In inhibition assay, sera were tested for their ability to inhibit the binding of murine antiidiotypic MoAbs to biotin conjugated anti HMW.MAA MoAbs.	Biotin	112-118	chondroitin sulfate proteoglycan 4	Homo sapiens	135-142
2273574-5	1990	In sandwich assay, sera were tested for their ability to bind to precoated murine antiidiotypic MoAb and to biotin conjugated anti HMW.MAA MoAbs.	Biotin	108-114	chondroitin sulfate proteoglycan 4	Homo sapiens	131-138
34952462-2	2022	Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutaredoxin 2 (Grx2c) regulates the redox state of the transcription factor SP-1 and thereby its binding affinity to both the promoter and an enhancer region of the CSPG4 gene encoding chondroitin sulfate proteoglycan nerve/glial antigen 2 (NG2).	Chondroitin Sulfates	276-295	chondroitin sulfate proteoglycan 4	Homo sapiens	256-261
34952462-2	2022	Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutaredoxin 2 (Grx2c) regulates the redox state of the transcription factor SP-1 and thereby its binding affinity to both the promoter and an enhancer region of the CSPG4 gene encoding chondroitin sulfate proteoglycan nerve/glial antigen 2 (NG2).	Chondroitin Sulfates	276-295	chondroitin sulfate proteoglycan 4	Homo sapiens	332-335
34593806-0	2021	NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety.	gamma-Aminobutyric Acid	17-21	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
34528358-3	2021	The azo-heptagon-embedded NG 1 leads to a saddle shape, and the azo-octagon-embedded NG 2 exhibits a distorted saddle-helix conformation with the largest torsion angle recorded so far in (5)helicenes.	azo-octagon	64-75	chondroitin sulfate proteoglycan 4	Homo sapiens	85-89
34528358-3	2021	The azo-heptagon-embedded NG 1 leads to a saddle shape, and the azo-octagon-embedded NG 2 exhibits a distorted saddle-helix conformation with the largest torsion angle recorded so far in (5)helicenes.	helicenes	190-199	chondroitin sulfate proteoglycan 4	Homo sapiens	85-89
34279819-3	2022	Recently, CSPG4 and FZD2 were reported to be the receptors that mediate TcdB cellular entry.	trimethylaminocarboxyldihydroboran	72-76	chondroitin sulfate proteoglycan 4	Homo sapiens	10-15
34509750-11	2021	Histopathological examination revealed that the NG2 expression was more intense in the group treated with phenytoin and levetiracetam (phenytoin was partly higher) and the amount of edema decreased.	Phenytoin	106-115	chondroitin sulfate proteoglycan 4	Homo sapiens	48-51
34509750-11	2021	Histopathological examination revealed that the NG2 expression was more intense in the group treated with phenytoin and levetiracetam (phenytoin was partly higher) and the amount of edema decreased.	Levetiracetam	120-133	chondroitin sulfate proteoglycan 4	Homo sapiens	48-51
34509750-11	2021	Histopathological examination revealed that the NG2 expression was more intense in the group treated with phenytoin and levetiracetam (phenytoin was partly higher) and the amount of edema decreased.	Phenytoin	135-144	chondroitin sulfate proteoglycan 4	Homo sapiens	48-51
34509750-12	2021	The NG2 expression increased and the edema decreased, though lower in the group treated with carbamazepine and valproic acid, compared with phenytoin and levetiracetam.	Carbamazepine	93-106	chondroitin sulfate proteoglycan 4	Homo sapiens	4-7
34509750-12	2021	The NG2 expression increased and the edema decreased, though lower in the group treated with carbamazepine and valproic acid, compared with phenytoin and levetiracetam.	Valproic Acid	111-124	chondroitin sulfate proteoglycan 4	Homo sapiens	4-7
34509750-12	2021	The NG2 expression increased and the edema decreased, though lower in the group treated with carbamazepine and valproic acid, compared with phenytoin and levetiracetam.	Phenytoin	140-149	chondroitin sulfate proteoglycan 4	Homo sapiens	4-7
34593806-4	2021	Here, we report that NG2 glia form synaptic complexes with hippocampal interneurons and that selective photostimulation of NG2 glia (expressing channelrhodopsin-2) functionally drives GABA release and enhances inhibitory synaptic transmission onto proximal interneurons in a microcircuit.	gamma-Aminobutyric Acid	184-188	chondroitin sulfate proteoglycan 4	Homo sapiens	21-24
35239034-6	2022	The versatility of the pretargeting approach was showcased in vitro using a series of fluorescein-binding bsAbs directed at various established cancer-associated targets, including the pan-carcinoma cell surface marker EpCAM, EGFR, melanoma marker MCSP (aka CSPG4), and immune checkpoint PD-L1, offering a range of potential future applications for this pretargeting platform.	Fluorescein	86-97	chondroitin sulfate proteoglycan 4	Homo sapiens	248-252
35501919-8	2022	We identified several genes that were commonly mutated in pre-NACT samples specific to platinum-resistant (CSPG4, SLC35G5, TUBA3D) or sensitive (CYP2D6, NUTM1, DNAH5) cases.	Platinum	87-95	chondroitin sulfate proteoglycan 4	Homo sapiens	107-112
35392631-14	2022	Other proteins (ORM1, APOE, NG2, CNTF) involved in NFkappaB-signaling were increased by SNI and decreased by DTMP.	2',3'-dideoxy-2',3'-didehydrothymidine monophosphate	109-113	chondroitin sulfate proteoglycan 4	Homo sapiens	28-31
35239034-6	2022	The versatility of the pretargeting approach was showcased in vitro using a series of fluorescein-binding bsAbs directed at various established cancer-associated targets, including the pan-carcinoma cell surface marker EpCAM, EGFR, melanoma marker MCSP (aka CSPG4), and immune checkpoint PD-L1, offering a range of potential future applications for this pretargeting platform.	Fluorescein	86-97	chondroitin sulfate proteoglycan 4	Homo sapiens	258-263
33903744-2	2021	Here, we show that the release-through the implantation of a hyaluronic acid hydrogel-of CAR-T cells targeting the human chondroitin sulfate proteoglycan 4, polymer nanoparticles encapsulating the cytokine interleukin-15 and platelets conjugated with the checkpoint inhibitor programmed death-ligand 1 into the tumour cavity of mice with a resected subcutaneous melanoma tumour inhibits the local recurrence of the tumour as well as the growth of distant tumours, through the abscopal effect.	Hyaluronic Acid	61-76	chondroitin sulfate proteoglycan 4	Homo sapiens	121-155
35127724-13	2021	In conclusion, CAV1, COL6A2, FABP4, FBLN1, PCOLCE, and CSPG4 were identified to be critical biomarkers through regulating the immune cell infiltration in an immune microenvironment of GEM-resistance and could act as promising treatment targets for GEM-resistant muscle-invasive BCa.	gemcitabine	184-187	chondroitin sulfate proteoglycan 4	Homo sapiens	55-60
2798319-3	1989	The present report describes the conjugation of dicesium-mercapto-undecahydrododecaborate (Cs2B12H11SH) to 225.28S monoclonal antibody directed against high molecular weight melanoma-associated antigens (HMW-MAA), using poly-L-ornithine as a "bridge" to increase the carrying capacity of the antibody and to minimize change in the conformational structure of antibody.	dicesium-mercapto-undecahydrododecaborate	48-89	chondroitin sulfate proteoglycan 4	Homo sapiens	152-202
2798319-3	1989	The present report describes the conjugation of dicesium-mercapto-undecahydrododecaborate (Cs2B12H11SH) to 225.28S monoclonal antibody directed against high molecular weight melanoma-associated antigens (HMW-MAA), using poly-L-ornithine as a "bridge" to increase the carrying capacity of the antibody and to minimize change in the conformational structure of antibody.	dicesium-mercapto-undecahydrododecaborate	48-89	chondroitin sulfate proteoglycan 4	Homo sapiens	204-211
2798319-3	1989	The present report describes the conjugation of dicesium-mercapto-undecahydrododecaborate (Cs2B12H11SH) to 225.28S monoclonal antibody directed against high molecular weight melanoma-associated antigens (HMW-MAA), using poly-L-ornithine as a "bridge" to increase the carrying capacity of the antibody and to minimize change in the conformational structure of antibody.	polyornithine	220-236	chondroitin sulfate proteoglycan 4	Homo sapiens	152-202
2916650-4	1989	The present study examined the tissue distribution of three prototype melanoma cell surface antigens, the Mr 57,000 glycoprotein (gp57) recognized by MAb A42, the GD3 ganglioside, and the mel-CSPG chondroitin sulfate proteoglycan.	Chondroitin Sulfates	197-216	chondroitin sulfate proteoglycan 4	Homo sapiens	188-196
3989605-0	1985	Immunoreactivity and biodistribution of indium-111-labeled monoclonal antibody to a human high molecular weight-melanoma associated antigen.	Indium-111	40-50	chondroitin sulfate proteoglycan 4	Homo sapiens	90-139
32546032-3	2021	Proliferation of cultured pericytes after treatment with cortisol and IL-1beta was analysed using radioactive labelled thymidine.Findings: The number of NG2+ pericytes was significantly higher in CMS animals than controls.	Hydrocortisone	57-65	chondroitin sulfate proteoglycan 4	Homo sapiens	153-156
33908562-6	2021	Furthermore, two structural variants of NG1, namely, NG2 and NG3, were synthesized, which suggest the crucial role of pyridine in imparting panchromatic emission properties and of both pyridine and acyl-thiourea side chain in the binding of Cu2+ ions.	pyridine	118-126	chondroitin sulfate proteoglycan 4	Homo sapiens	53-56
33908562-6	2021	Furthermore, two structural variants of NG1, namely, NG2 and NG3, were synthesized, which suggest the crucial role of pyridine in imparting panchromatic emission properties and of both pyridine and acyl-thiourea side chain in the binding of Cu2+ ions.	cupric ion	241-245	chondroitin sulfate proteoglycan 4	Homo sapiens	53-56
2472474-2	1989	In vitro incubation of melanoma cells with a combination of the three 125I-labeled anti-HMW-MAA MoAbs results in a marked additive binding only when the MoAbs are used at saturating concentrations.	Iodine-125	70-74	chondroitin sulfate proteoglycan 4	Homo sapiens	88-95
33864501-3	2021	In the present study, we directly examined the identities and distributions of NG2- and PDGFR-beta-positive cells in the control and lesioned striatum injured by the mitochondrial toxin 3-nitropropionic acid.	3-nitropropionic acid	186-207	chondroitin sulfate proteoglycan 4	Homo sapiens	79-82
33864501-0	2021	Temporal dynamics of cells expressing NG2 and platelet-derived growth factor receptor-beta in the fibrotic scar formation after 3-nitropropionic acid-induced acute brain injury.	3-nitropropionic acid	128-149	chondroitin sulfate proteoglycan 4	Homo sapiens	38-41
33202114-0	2021	A triple sense of oxygen promotes neurovascular angiogenesis in NG2-derived cells.	Oxygen	18-24	chondroitin sulfate proteoglycan 4	Homo sapiens	64-67
33918235-4	2021	For this purpose, CK2 activity was suppressed in the NG2-positive cell lines A1207 and U87 by the pharmacological inhibitor CX-4945 and CRISPR/Cas9-mediated knockout of CK2alpha.	silmitasertib	124-131	chondroitin sulfate proteoglycan 4	Homo sapiens	53-56
33918235-10	2021	Therefore, CX-4945 may be a suitable drug for the future treatment of NG2-positive GBM.	silmitasertib	11-18	chondroitin sulfate proteoglycan 4	Homo sapiens	70-73
33727640-9	2021	CSPG4, MCAM, and AOC3 responded to the MRTF-SRF inhibitor CCG-1423, to actin dynamics, and to ternary complex factors.	CCG 1423	58-66	chondroitin sulfate proteoglycan 4	Homo sapiens	0-5
33202114-3	2021	1 demonstrate how NG2-derived cells in the brain sense oxygen to promote neurovascular angiogenesis.	Oxygen	55-61	chondroitin sulfate proteoglycan 4	Homo sapiens	18-21
32722269-6	2020	Moreover, NaHS (10 muM), continuously administered in culture for 21 days, was able to significantly reduce NG2, Nestin and PDGFR-beta expression.	sodium bisulfide	10-14	chondroitin sulfate proteoglycan 4	Homo sapiens	108-111
33189883-13	2021	EtOH exposure also was associated with an increase in the proportion of cells expressing markers of early stage OPCs, such as A2B5 and NG2.	Ethanol	0-4	chondroitin sulfate proteoglycan 4	Homo sapiens	135-138
32719776-0	2020	Changes in Structure and Reactivity of Ng2 Encapsulated in Fullerenes: A Density Functional Theory Study.	Fullerenes	59-69	chondroitin sulfate proteoglycan 4	Homo sapiens	39-42
32719776-3	2020	In this contribution, we systematically investigate the impact of fullerene encapsulation on molecular structure and chemical reactivity of noble gas dimers (Ng2) in a few fullerene molecules.	Fullerenes	66-75	chondroitin sulfate proteoglycan 4	Homo sapiens	158-161
32719776-3	2020	In this contribution, we systematically investigate the impact of fullerene encapsulation on molecular structure and chemical reactivity of noble gas dimers (Ng2) in a few fullerene molecules.	Fullerenes	172-181	chondroitin sulfate proteoglycan 4	Homo sapiens	158-161
32719776-5	2020	We unveil that bond distances of Ng2 inside fullerene become substantially smaller and noble gas atoms become more electrophilic.	Fullerenes	44-53	chondroitin sulfate proteoglycan 4	Homo sapiens	33-36
32599896-0	2020	Chondroitin Sulphate Proteoglycan 4 (NG2/CSPG4) Localization in Low- and High-Grade Gliomas.	Chondroitin Sulfates	0-20	chondroitin sulfate proteoglycan 4	Homo sapiens	37-40
32599896-0	2020	Chondroitin Sulphate Proteoglycan 4 (NG2/CSPG4) Localization in Low- and High-Grade Gliomas.	Chondroitin Sulfates	0-20	chondroitin sulfate proteoglycan 4	Homo sapiens	41-46
32599896-1	2020	BACKGROUND: Neuron glial antigen 2 or chondroitin sulphate proteoglycan 4 (NG2/CSPG4) is expressed by immature precursors/progenitor cells and is possibly involved in malignant cell transformation.	Chondroitin Sulfates	38-58	chondroitin sulfate proteoglycan 4	Homo sapiens	75-78
32599896-1	2020	BACKGROUND: Neuron glial antigen 2 or chondroitin sulphate proteoglycan 4 (NG2/CSPG4) is expressed by immature precursors/progenitor cells and is possibly involved in malignant cell transformation.	Chondroitin Sulfates	38-58	chondroitin sulfate proteoglycan 4	Homo sapiens	79-84
32331232-6	2020	Furthermore, c-REL inhibition with pentoxifylline (PTXF) resulted in a complete shift towards oligodendroglial fate, as demonstrated by the presence of OLIG2+/O4+-oligodendrocytes, which showed PDGFRalpha, NG2 and MBP at the transcript level.	Pentoxifylline	35-49	chondroitin sulfate proteoglycan 4	Homo sapiens	206-209
32331232-6	2020	Furthermore, c-REL inhibition with pentoxifylline (PTXF) resulted in a complete shift towards oligodendroglial fate, as demonstrated by the presence of OLIG2+/O4+-oligodendrocytes, which showed PDGFRalpha, NG2 and MBP at the transcript level.	Pentoxifylline	51-55	chondroitin sulfate proteoglycan 4	Homo sapiens	206-209
32331483-0	2020	A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma.	Chondroitin Sulfates	82-101	chondroitin sulfate proteoglycan 4	Homo sapiens	116-121
32183204-11	2020	However, the NG2- and CD146-positive neovessels had significantly higher densities in the TOF-HIS group than in the TOF-IIS group.	Histidine	94-97	chondroitin sulfate proteoglycan 4	Homo sapiens	13-16
32265656-9	2020	Neuronal cells, astrocytes, microglia, NG2 glia, and oligodendrocytes all have their roles in what is known as glutamate excitotoxicity.	Glutamic Acid	111-120	chondroitin sulfate proteoglycan 4	Homo sapiens	39-42
31859500-1	2020	Two novel homo and hetero three-dimensional nanographenes - NG1 and NG2 - featuring a cyclooctatetraene core are designed, synthetized, and characterized.	1,3,5,7-cyclooctatetraene	86-103	chondroitin sulfate proteoglycan 4	Homo sapiens	68-71
31769737-4	2020	We generated a rat IgE against the human tumor-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) and cross-reactive for the rat antigen.	Sulfates	78-85	chondroitin sulfate proteoglycan 4	Homo sapiens	102-107
31140988-0	2019	Chondroitin sulfate proteoglycan 4 enhanced melanoma motility and growth requires a cysteine in the core protein transmembrane domain.	Cysteine	84-92	chondroitin sulfate proteoglycan 4	Homo sapiens	0-34
31578248-6	2019	Competitive enzyme-linked immunosorbent assays (ELISAs) showed that D16 blocks interactions between TcdB and its receptor, chondroitin sulfate proteoglycan 4 (CSPG4).	trimethylaminocarboxyldihydroboran	100-104	chondroitin sulfate proteoglycan 4	Homo sapiens	159-164
31578248-6	2019	Competitive enzyme-linked immunosorbent assays (ELISAs) showed that D16 blocks interactions between TcdB and its receptor, chondroitin sulfate proteoglycan 4 (CSPG4).	Chondroitin Sulfates	123-142	chondroitin sulfate proteoglycan 4	Homo sapiens	159-164
31426437-0	2019	Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance.	guanosine 5'-monophosphorothioate	136-139	chondroitin sulfate proteoglycan 4	Homo sapiens	106-111
31368564-5	2019	The results revealed that the optimal conditions for the reverse synthesis were as follows: nG2 :nbeta-CD , 8:1; enzyme concentration, 60 U/ml; reaction temperature, 60 C; pH, 4.5; reaction time, 60 hr.	nbeta-cd	97-105	chondroitin sulfate proteoglycan 4	Homo sapiens	92-95
31140988-5	2019	Enhanced directional motility promoted by this complex also requires a CSPG4 transmembrane cysteine residue C2230.	Cysteine	91-99	chondroitin sulfate proteoglycan 4	Homo sapiens	71-76
31140988-5	2019	Enhanced directional motility promoted by this complex also requires a CSPG4 transmembrane cysteine residue C2230.	c2230	108-113	chondroitin sulfate proteoglycan 4	Homo sapiens	71-76
31140988-6	2019	Substituting C2230 with alanine (CSPG4) still permits assembly of the signaling complex, however Src remains in an inactive state.	Alanine	24-31	chondroitin sulfate proteoglycan 4	Homo sapiens	33-38
31006910-0	2019	Furanodienone overcomes temozolomide resistance in glioblastoma through the downregulation of CSPG4-Akt-ERK signalling by inhibiting EGR1-dependent transcription.	furanodienone	0-13	chondroitin sulfate proteoglycan 4	Homo sapiens	94-99
31195686-7	2019	More importantly, CSPG4-specific CAR T cells evinced specific degranulation towards KOPN8 cells and specifically lysed KOPN8 target cells in chromium lysis experiments.	Chromium	141-149	chondroitin sulfate proteoglycan 4	Homo sapiens	18-23
30635633-5	2019	We here hypothesized that blocking NG2 may synergize with established induction therapy for B-ALL based on vincristine, glucocorticoids, and L-asparaginase (VxL).	Vincristine	107-118	chondroitin sulfate proteoglycan 4	Homo sapiens	35-38
31217827-11	2019	Moreover, CSPG4 immune-targeting has been shown to potentiate the effect of doxorubicin.	Doxorubicin	76-87	chondroitin sulfate proteoglycan 4	Homo sapiens	10-15
31006910-0	2019	Furanodienone overcomes temozolomide resistance in glioblastoma through the downregulation of CSPG4-Akt-ERK signalling by inhibiting EGR1-dependent transcription.	Temozolomide	24-36	chondroitin sulfate proteoglycan 4	Homo sapiens	94-99
31006910-4	2019	In this study, we found that furanodienone (FUR), a diene-type sesquiterpene isolated from the rhizomes of Rhizoma curcumae, exhibited a potential cytotoxic effect on temozolomide (TMZ)-resistant GBM cells in vitro by inhibiting CSPG4 and related signalling pathways.	furanodienone	29-42	chondroitin sulfate proteoglycan 4	Homo sapiens	229-234
31006910-4	2019	In this study, we found that furanodienone (FUR), a diene-type sesquiterpene isolated from the rhizomes of Rhizoma curcumae, exhibited a potential cytotoxic effect on temozolomide (TMZ)-resistant GBM cells in vitro by inhibiting CSPG4 and related signalling pathways.	furanodienone	44-47	chondroitin sulfate proteoglycan 4	Homo sapiens	229-234
31006910-4	2019	In this study, we found that furanodienone (FUR), a diene-type sesquiterpene isolated from the rhizomes of Rhizoma curcumae, exhibited a potential cytotoxic effect on temozolomide (TMZ)-resistant GBM cells in vitro by inhibiting CSPG4 and related signalling pathways.	Temozolomide	167-179	chondroitin sulfate proteoglycan 4	Homo sapiens	229-234
31006910-5	2019	Studies investigating the mechanism demonstrated that FUR suppressed CSPG4-Akt-ERK signalling, inflammatory responses, and cytokine levels but activated caspase-dependent pathways and mitochondrial dysfunction.	furanodienone	54-57	chondroitin sulfate proteoglycan 4	Homo sapiens	69-74
31006910-6	2019	Furthermore, an immunofluorescence assay and a dual-luciferase reporter assay revealed that inhibition of EGR1-mediated transcription might have contributed to the FUR-dependent blockade of CSPG4 signalling and glioma cell survival.	furanodienone	164-167	chondroitin sulfate proteoglycan 4	Homo sapiens	190-195
31006910-7	2019	These results established a link between FUR-induced CSPG4 inhibition and the suppression of EGR1-dependent transcription.	furanodienone	41-44	chondroitin sulfate proteoglycan 4	Homo sapiens	53-58
31006910-8	2019	Attenuation of ERK1/2 and cytokine signalling might have generated the EGR1-dependent negative feedback loop of the CSPG4 pathway during FUR-induced apoptosis.	furanodienone	137-140	chondroitin sulfate proteoglycan 4	Homo sapiens	116-121
31006910-9	2019	These findings suggested that FUR could be a therapeutic candidate for the treatment of malignant glioma via targeting CSPG4 signalling.	furanodienone	30-33	chondroitin sulfate proteoglycan 4	Homo sapiens	119-124
30771386-6	2019	Cellular uptake and cytotoxicity evaluation demonstrated that NG1/DOX could be successfully degraded and efficiently release DOX in acid cell organelles, leading to higher cytotoxicity than NG2/DOX.	Doxorubicin	66-69	chondroitin sulfate proteoglycan 4	Homo sapiens	190-193
30092984-3	2018	Doxorubicin (DOX) was successfully loaded into NG1 and NG2 to give NG1/DOX and NG2/DOX, both of them showed appropriate drug release profiles under mildly acidic conditions (pH 5.0).	Doxorubicin	0-11	chondroitin sulfate proteoglycan 4	Homo sapiens	55-58
31583586-3	2019	A significant population of OPCs persists in the adult CNS, where they are often referred to as NG2-glia, because they are identified by their expression of the NG2 chondroitin sulphate proteoglycan (CSPG4).	Chondroitin	165-185	chondroitin sulfate proteoglycan 4	Homo sapiens	96-99
31583586-3	2019	A significant population of OPCs persists in the adult CNS, where they are often referred to as NG2-glia, because they are identified by their expression of the NG2 chondroitin sulphate proteoglycan (CSPG4).	Chondroitin	165-185	chondroitin sulfate proteoglycan 4	Homo sapiens	161-164
31583586-3	2019	A significant population of OPCs persists in the adult CNS, where they are often referred to as NG2-glia, because they are identified by their expression of the NG2 chondroitin sulphate proteoglycan (CSPG4).	Chondroitin	165-185	chondroitin sulfate proteoglycan 4	Homo sapiens	200-205
31583586-5	2019	NG2-glia contact synapses and respond to neurotransmitters and potassium released during neuronal transmission; to this end, NG2-glia (OPCs) express multiple neurotransmitter receptors and ion channels, with prominent roles being identified for glutamatergic signalling and potassium channels in oligodendrocyte differentiation.	Potassium	63-72	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
31583586-5	2019	NG2-glia contact synapses and respond to neurotransmitters and potassium released during neuronal transmission; to this end, NG2-glia (OPCs) express multiple neurotransmitter receptors and ion channels, with prominent roles being identified for glutamatergic signalling and potassium channels in oligodendrocyte differentiation.	Potassium	274-283	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
31583586-5	2019	NG2-glia contact synapses and respond to neurotransmitters and potassium released during neuronal transmission; to this end, NG2-glia (OPCs) express multiple neurotransmitter receptors and ion channels, with prominent roles being identified for glutamatergic signalling and potassium channels in oligodendrocyte differentiation.	Potassium	274-283	chondroitin sulfate proteoglycan 4	Homo sapiens	125-128
30092984-3	2018	Doxorubicin (DOX) was successfully loaded into NG1 and NG2 to give NG1/DOX and NG2/DOX, both of them showed appropriate drug release profiles under mildly acidic conditions (pH 5.0).	Doxorubicin	0-11	chondroitin sulfate proteoglycan 4	Homo sapiens	79-82
30092984-3	2018	Doxorubicin (DOX) was successfully loaded into NG1 and NG2 to give NG1/DOX and NG2/DOX, both of them showed appropriate drug release profiles under mildly acidic conditions (pH 5.0).	Doxorubicin	13-16	chondroitin sulfate proteoglycan 4	Homo sapiens	55-58
30092984-3	2018	Doxorubicin (DOX) was successfully loaded into NG1 and NG2 to give NG1/DOX and NG2/DOX, both of them showed appropriate drug release profiles under mildly acidic conditions (pH 5.0).	Doxorubicin	13-16	chondroitin sulfate proteoglycan 4	Homo sapiens	79-82
30092984-3	2018	Doxorubicin (DOX) was successfully loaded into NG1 and NG2 to give NG1/DOX and NG2/DOX, both of them showed appropriate drug release profiles under mildly acidic conditions (pH 5.0).	Doxorubicin	71-74	chondroitin sulfate proteoglycan 4	Homo sapiens	55-58
30092984-3	2018	Doxorubicin (DOX) was successfully loaded into NG1 and NG2 to give NG1/DOX and NG2/DOX, both of them showed appropriate drug release profiles under mildly acidic conditions (pH 5.0).	Doxorubicin	71-74	chondroitin sulfate proteoglycan 4	Homo sapiens	55-58
30092984-4	2018	NG2/DOX possessed higher drug enrichment and lethality than NG1/DOX did on MCF-7/ADR cells.	Doxorubicin	4-7	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
30092984-5	2018	Analysis of corresponding index of efflux activity showed that NG2 could induce depolarization of mitochondrial membrane and interfere with ATP metabolism.	Adenosine Triphosphate	140-143	chondroitin sulfate proteoglycan 4	Homo sapiens	63-66
29957113-9	2018	However, the densities of NG2- and CD146-positive neovessels were significantly lower in the high IPH group than in the low IPH group (5.7 +- 0.5 vs. 17.1 +- 2.4, p < 0.0001; 6.6 +- 0.8 vs. 18.4 +- 2.5, p < 0.0001, respectively).CONCLUSIONSPlaques with high IPH are associated with fewer pericytes in the intraplaque neovessels.	Phenol	98-101	chondroitin sulfate proteoglycan 4	Homo sapiens	26-29
29730261-3	2018	Both NG1 and NG2 displayed excellent stability in neutral environment, while showed pH-triggered degradation behaviors under mildly acidic conditions resulting from the breakage of ortho ester bonds.	Esters	187-192	chondroitin sulfate proteoglycan 4	Homo sapiens	13-16
29770934-3	2018	Total mercury concentrations closer to shore (NG2) ranged between 0.073 +- 0.001 and 0.27 +- 0.01 mug/g, and between 0.038 +- 0.001 and 0.214 +- 0.008 mug/g at a site deeper in the lake (NG3).	Mercury	6-13	chondroitin sulfate proteoglycan 4	Homo sapiens	46-49
29770934-4	2018	Total mercury fluxes ranged between 0.144 +- 0.002 and 3.0 +- 0.1 mug/m2/day at NG2, and between 0.102 +- 0.008 and 1.32 +- 0.08 mug/m2/day at NG3.	Mercury	6-13	chondroitin sulfate proteoglycan 4	Homo sapiens	80-83
29565434-1	2018	Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan 4 (CSPG4/NG2).	Chondroitin Sulfates	127-146	chondroitin sulfate proteoglycan 4	Homo sapiens	163-168
29565434-1	2018	Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan 4 (CSPG4/NG2).	Chondroitin Sulfates	127-146	chondroitin sulfate proteoglycan 4	Homo sapiens	169-172
29126016-6	2017	Importantly, the functions of the kon and pros homologues NG2 and prox1, respectively, are conserved in mammalian NG2 glia.	Proline	42-46	chondroitin sulfate proteoglycan 4	Homo sapiens	58-61
29462330-0	2018	Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.	Heparitin Sulfate	88-104	chondroitin sulfate proteoglycan 4	Homo sapiens	13-48
29462330-0	2018	Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.	Heparitin Sulfate	88-104	chondroitin sulfate proteoglycan 4	Homo sapiens	50-55
29462330-3	2018	CSPG4 from the two melanoma cell lines differed in the amount of chondroitin sulphate (CS) decoration, as well as the way the protein core was fragmented.	Chondroitin Sulfates	65-85	chondroitin sulfate proteoglycan 4	Homo sapiens	0-5
29462330-4	2018	In contrast, the CSPG4 expressed by a colon carcinoma cell line, WiDr, was predominantly as a protein core on the cell surface lacking glycosaminoglycan (GAG) chains.	Glycosaminoglycans	135-152	chondroitin sulfate proteoglycan 4	Homo sapiens	17-22
29462330-4	2018	In contrast, the CSPG4 expressed by a colon carcinoma cell line, WiDr, was predominantly as a protein core on the cell surface lacking glycosaminoglycan (GAG) chains.	Glycosaminoglycans	154-157	chondroitin sulfate proteoglycan 4	Homo sapiens	17-22
29022246-4	2018	Surprisingly, ALA significantly stimulates population of NG2 chondroitin sulfate proteoglycan positive glia (NG2+ cells or polydendrocytes), from week 4 afterward.	Thioctic Acid	14-17	chondroitin sulfate proteoglycan 4	Homo sapiens	57-60
29022246-4	2018	Surprisingly, ALA significantly stimulates population of NG2 chondroitin sulfate proteoglycan positive glia (NG2+ cells or polydendrocytes), from week 4 afterward.	Thioctic Acid	14-17	chondroitin sulfate proteoglycan 4	Homo sapiens	109-112
29274429-0	2018	Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth.	Tretinoin	0-13	chondroitin sulfate proteoglycan 4	Homo sapiens	27-30
29126016-6	2017	Importantly, the functions of the kon and pros homologues NG2 and prox1, respectively, are conserved in mammalian NG2 glia.	Proline	42-46	chondroitin sulfate proteoglycan 4	Homo sapiens	114-117
28433626-8	2017	Compared to pre-DMPA endometria (n=5), stromal cells in post-DMPA endometria (n=5) displayed stronger CSPG4 immunostaining.	dmpa	61-65	chondroitin sulfate proteoglycan 4	Homo sapiens	102-107
27644104-0	2016	NG2 glial cells integrate synaptic input in global and dendritic calcium signals.	Calcium	65-72	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
27877042-6	2016	The flux rates of citral decreased in the order NE (1,026 mug/cm2) > NG1 (1,021 mug/cm2) > NG2 (541 mug/cm2) > NG3 (353 mug/cm2).	citral	18-24	chondroitin sulfate proteoglycan 4	Homo sapiens	97-100
27665146-9	2016	RESULTS: Water significantly increased the modulus of NG1 and NG2 dispersed in solvent, while significantly decreased the stiffness of NG3.	Water	9-14	chondroitin sulfate proteoglycan 4	Homo sapiens	62-65
27665146-11	2016	NG2 showed the highest DC in solvent and BisGMA/HEMA.	Deoxycytidine	23-25	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
27665146-11	2016	NG2 showed the highest DC in solvent and BisGMA/HEMA.	Bisphenol A-Glycidyl Methacrylate	41-47	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
27665146-11	2016	NG2 showed the highest DC in solvent and BisGMA/HEMA.	hydroxyethyl methacrylate	48-52	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
27877042-5	2016	Ex vivo skin permeation tests indicated that the percutaneous flux rates of terbinafine decreased in the order NE (215 mug/cm2) > NG1 (213 mug/cm2) > NG2 (123 mug/cm2) > NG3 (74.3 mug/cm2).	Terbinafine	76-87	chondroitin sulfate proteoglycan 4	Homo sapiens	156-159
27644104-2	2016	Here we show that NG2 cells perform linear integration of glutamatergic synaptic inputs and respond with increasing dendritic calcium elevations.	Calcium	126-133	chondroitin sulfate proteoglycan 4	Homo sapiens	18-21
27048321-11	2016	Functional studies in GH4 mammosomatotrophs showed that NG2 increases prolactin (PRL), reduces growth hormone (GH) expression, and enhances cell adhesion without influencing proliferation.	GH4	22-25	chondroitin sulfate proteoglycan 4	Homo sapiens	56-59
26232070-2	2016	This reaction is characterized by the retraction of cell processes, cell body swelling and increased expression of the NG2 chondroitin sulfate proteoglycan.	Chondroitin Sulfates	123-142	chondroitin sulfate proteoglycan 4	Homo sapiens	119-122
26461094-3	2015	In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4.	Chondroitin Sulfates	26-28	chondroitin sulfate proteoglycan 4	Homo sapiens	125-130
27292772-4	2016	Chondrosarcoma cells in which CSPG4/NG2 was knocked down were more sensitive to doxorubicin than wild-type cells.	Doxorubicin	80-91	chondroitin sulfate proteoglycan 4	Homo sapiens	30-35
27292772-4	2016	Chondrosarcoma cells in which CSPG4/NG2 was knocked down were more sensitive to doxorubicin than wild-type cells.	Doxorubicin	80-91	chondroitin sulfate proteoglycan 4	Homo sapiens	36-39
25997619-11	2015	Polyclonal anti-CSPG4-antibodies reduced the Transwell migration of vemurafenib-treated, BRAF V600E-mutant and CSPG4-expressing melanoma cells in hypoxia.	Vemurafenib	68-79	chondroitin sulfate proteoglycan 4	Homo sapiens	16-21
25934281-5	2015	Poly(lactic-co-glycolic acid)-based nanoparticles of ~120 nm diameter were constructed with LIF as cargo (LIF-NP) with surface antibodies against NG-2 chondroitin sulfate proteoglycan, expressed on OPC.	Polylactic Acid-Polyglycolic Acid Copolymer	0-29	chondroitin sulfate proteoglycan 4	Homo sapiens	146-150
25997619-13	2015	Our results highlight CSPG4 as a potential target for modulating treatment resistance to vemurafenib induced by the hypoxic microenvironment.	Vemurafenib	89-100	chondroitin sulfate proteoglycan 4	Homo sapiens	22-27
24354860-9	2014	The expression level of polyLacNAc of CSPG4 in WM266-4 cells was significantly higher than that in WM115 cells.	polylacnac	24-34	chondroitin sulfate proteoglycan 4	Homo sapiens	38-43
25987129-5	2015	We further demonstrate that microRNA 129-2 (miR129-2) is downregulated and hypermethylated in human DIPGs, resulting in the increased expression of NG2.	dipgs	100-105	chondroitin sulfate proteoglycan 4	Homo sapiens	148-151
25987129-6	2015	Treatment with 5-Azacytidine, a methyltransferase inhibitor, results in NG2 downregulation in DIPG primary tumor cells in vitro.	Azacitidine	15-28	chondroitin sulfate proteoglycan 4	Homo sapiens	72-75
25987129-6	2015	Treatment with 5-Azacytidine, a methyltransferase inhibitor, results in NG2 downregulation in DIPG primary tumor cells in vitro.	Dipinacoline glutamate	94-98	chondroitin sulfate proteoglycan 4	Homo sapiens	72-75
26178214-7	2015	Compared with the saline control group, the numbers of NG2 positive cells increased in RhEPO treatment group.	Sodium Chloride	18-24	chondroitin sulfate proteoglycan 4	Homo sapiens	55-58
25530119-7	2015	In the cuprizone-induced demyelination model, there was a dramatic increase in NG2-expressing cells with nuclear location of Olig1 in the corpus callosum during remyelination.	Cuprizone	7-16	chondroitin sulfate proteoglycan 4	Homo sapiens	79-82
24354860-10	2014	In addition, sulfation patterns of chondroitin sulfate (CS) chains in CSPG4 showed dramatic changes between these cell lines.	Chondroitin Sulfates	35-54	chondroitin sulfate proteoglycan 4	Homo sapiens	70-75
24354860-10	2014	In addition, sulfation patterns of chondroitin sulfate (CS) chains in CSPG4 showed dramatic changes between these cell lines.	Chondroitin Sulfates	56-58	chondroitin sulfate proteoglycan 4	Homo sapiens	70-75
23359523-0	2013	Human Ng2+ adipose stem cells loaded in vivo on a new crosslinked hyaluronic acid-Lys scaffold fabricate a skeletal muscle tissue.	Hyaluronic Acid	66-81	chondroitin sulfate proteoglycan 4	Homo sapiens	6-9
23925489-6	2014	siRNA-mediated NG2 knockdown in pericytes leads to reduced formation of pericyte/endothelial networks, reduced formation of ZO-1 positive endothelial cell junctions, and increased permeability of endothelial cell monolayers.	zo-1	124-128	chondroitin sulfate proteoglycan 4	Homo sapiens	15-18
23953863-6	2013	METHODS AND RESULTS: Immunoreactive CSPG4 localized to EVT cells in the trophoblast shell, subpopulations of interstitial EVT cells within the decidua and cytotrophoblast cells in placental villi.	EVT	55-58	chondroitin sulfate proteoglycan 4	Homo sapiens	36-41
23953863-10	2013	These data suggest that locally produced CSPG4 stimulates human EVT migration and invasion and suggests that IL11 and LIF regulate villous cytotrophoblast differentiation towards the invasive phenotype at least in part via CSPG4.	EVT	64-67	chondroitin sulfate proteoglycan 4	Homo sapiens	41-46
24278309-0	2013	Acetate supplementation induces growth arrest of NG2/PDGFRalpha-positive oligodendroglioma-derived tumor-initiating cells.	Acetates	0-7	chondroitin sulfate proteoglycan 4	Homo sapiens	49-52
23359523-0	2013	Human Ng2+ adipose stem cells loaded in vivo on a new crosslinked hyaluronic acid-Lys scaffold fabricate a skeletal muscle tissue.	Lysine	82-85	chondroitin sulfate proteoglycan 4	Homo sapiens	6-9
23249362-6	2013	Compared to OPCs derived from hESCs grown on ECM of animal origin, higher levels of NG2, a chondroitin sulfate proteoglycan expressed by OPCs, were observed in OPCs differentiated from H1 hESCs grown on VN-PAS, while the expression levels of Nestin and PDGFRalpha were comparable.	Chondroitin Sulfates	91-110	chondroitin sulfate proteoglycan 4	Homo sapiens	84-87
23729403-6	2013	Furthermore, BIBF 1120 showed potent antiangiogenic effects, including decreases in microvessel density (CD31), pericyte coverage (NG2), vessel permeability, and perfusion, while increasing hypoxia.	bibf	13-17	chondroitin sulfate proteoglycan 4	Homo sapiens	131-134
22699001-3	2012	Conversely, the expression of NG2 in mesenchymal sarcoma K2 cells as well as in A375M2 cells resulted in an enhanced amoeboid phenotype associated with increased invasiveness and elevated Rho-GTP levels.	Guanosine Triphosphate	192-195	chondroitin sulfate proteoglycan 4	Homo sapiens	30-33
21863242-12	2011	Our data establish NG2 as an important prognostic factor for GBM patient survival, by mediating resistance to radiotherapy through induction of ROS scavenging enzymes and preferential DNA damage signalling.	ros	144-147	chondroitin sulfate proteoglycan 4	Homo sapiens	19-22
22781335-6	2012	We investigated the cell fate of NG2 cells following SD-induced proliferation using 5"-bromodeoxyuridine labeling and immunohistochemical analysis.	Bromodeoxyuridine	84-104	chondroitin sulfate proteoglycan 4	Homo sapiens	33-36
21941360-8	2011	These cells located in the basal layer were negative for connexin-43 and positive for melanoma-associated chondroitin sulfate proteoglycan, containing holoclones with 0.2% CFE, thus representing the SC population.	holoclones	151-161	chondroitin sulfate proteoglycan 4	Homo sapiens	86-138
21482159-1	2011	Chondroitin sulfate proteoglycan-4 (CSPG4), also known as high molecular weight-melanoma associated antigen (HMW-MAA), is a membrane-bound chondroitin sulfate proteoglycan highly expressed by human melanoma cells.	Chondroitin Sulfates	139-158	chondroitin sulfate proteoglycan 4	Homo sapiens	0-34
21482159-1	2011	Chondroitin sulfate proteoglycan-4 (CSPG4), also known as high molecular weight-melanoma associated antigen (HMW-MAA), is a membrane-bound chondroitin sulfate proteoglycan highly expressed by human melanoma cells.	Chondroitin Sulfates	139-158	chondroitin sulfate proteoglycan 4	Homo sapiens	36-41
21482159-1	2011	Chondroitin sulfate proteoglycan-4 (CSPG4), also known as high molecular weight-melanoma associated antigen (HMW-MAA), is a membrane-bound chondroitin sulfate proteoglycan highly expressed by human melanoma cells.	Chondroitin Sulfates	139-158	chondroitin sulfate proteoglycan 4	Homo sapiens	58-107
21482159-1	2011	Chondroitin sulfate proteoglycan-4 (CSPG4), also known as high molecular weight-melanoma associated antigen (HMW-MAA), is a membrane-bound chondroitin sulfate proteoglycan highly expressed by human melanoma cells.	Chondroitin Sulfates	139-158	chondroitin sulfate proteoglycan 4	Homo sapiens	109-116
22108818-1	2011	NG2 cells are a novel distinct class of central nervous system (CNS) glial cells, characterized by the expression of the chondroitin sulfate proteoglycan NG2.	Chondroitin Sulfates	121-140	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
22108818-1	2011	NG2 cells are a novel distinct class of central nervous system (CNS) glial cells, characterized by the expression of the chondroitin sulfate proteoglycan NG2.	Chondroitin Sulfates	121-140	chondroitin sulfate proteoglycan 4	Homo sapiens	154-157
21352226-6	2011	Surprisingly, recent reports demonstrated that NG2 cells detect quantal glutamate release from unmyelinated axons in white matter regions.	Glutamic Acid	72-81	chondroitin sulfate proteoglycan 4	Homo sapiens	47-50
21717063-5	2011	Addition of 225.28 to the treatment regimen enhanced the in vitro response magnitude and the duration efficacy of PLX4032 in treating CSPG4(+), BRAF(V600E) melanoma cells (melanoma(BRAF(V600E)/CSPG4+) cells).	Vemurafenib	114-121	chondroitin sulfate proteoglycan 4	Homo sapiens	134-139
21717063-5	2011	Addition of 225.28 to the treatment regimen enhanced the in vitro response magnitude and the duration efficacy of PLX4032 in treating CSPG4(+), BRAF(V600E) melanoma cells (melanoma(BRAF(V600E)/CSPG4+) cells).	Vemurafenib	114-121	chondroitin sulfate proteoglycan 4	Homo sapiens	193-198
21352226-8	2011	In addition, we recently reported a new mode of extrasynaptic communication between neurones and NG2 cells that relies on pure GABA spillover and does not require GABAergic synaptic input.	gamma-Aminobutyric Acid	127-131	chondroitin sulfate proteoglycan 4	Homo sapiens	97-100
21658254-0	2011	Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells.	Chondroitin Sulfates	0-20	chondroitin sulfate proteoglycan 4	Homo sapiens	79-84
19785924-1	2009	Cells that express the NG2 chondroitin sulfate proteoglycan and platelet-derived growth factor receptor alpha (NG2 glia) are widespread in the adult human cerebral cortex and white matter and represent 10-15% of non-neuronal cells.	Chondroitin Sulfates	27-46	chondroitin sulfate proteoglycan 4	Homo sapiens	23-26
21092273-10	2010	Anti-MCSP:TRAIL activity was further synergized by co-treatment with rimcazole, a sigma-ligand currently in clinical trials for the treatment of various cancers.	rimcazole	69-78	chondroitin sulfate proteoglycan 4	Homo sapiens	5-9
20043946-5	2010	These synaptic NG2 cells respond to neuronal release of glutamate and GABA.	Glutamic Acid	56-65	chondroitin sulfate proteoglycan 4	Homo sapiens	15-18
20043946-5	2010	These synaptic NG2 cells respond to neuronal release of glutamate and GABA.	gamma-Aminobutyric Acid	70-74	chondroitin sulfate proteoglycan 4	Homo sapiens	15-18
20043946-8	2010	Since GRIP can bind subunits of the AMPA receptors expressed by NG2 cells, the interaction between GRIP and NG2 may orientate the glial AMPA receptors towards sites of neuronal glutamate release.	Glutamic Acid	177-186	chondroitin sulfate proteoglycan 4	Homo sapiens	64-67
20043946-8	2010	Since GRIP can bind subunits of the AMPA receptors expressed by NG2 cells, the interaction between GRIP and NG2 may orientate the glial AMPA receptors towards sites of neuronal glutamate release.	Glutamic Acid	177-186	chondroitin sulfate proteoglycan 4	Homo sapiens	108-111
20651032-0	2010	NG2-expressing glial precursor cells are a new potential oligodendroglioma cell initiating population in N-ethyl-N-nitrosourea-induced gliomagenesis.	Ethylnitrosourea	105-126	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
20448346-1	2010	The high molecular weight melanoma-associated antigen (HMW-MAA) is a membrane-bound chondroitin sulphate proteoglycan that is highly expressed on the surface of melanoma cells.	Chondroitin Sulfates	84-104	chondroitin sulfate proteoglycan 4	Homo sapiens	4-53
20448346-1	2010	The high molecular weight melanoma-associated antigen (HMW-MAA) is a membrane-bound chondroitin sulphate proteoglycan that is highly expressed on the surface of melanoma cells.	Chondroitin Sulfates	84-104	chondroitin sulfate proteoglycan 4	Homo sapiens	55-62
20448346-4	2010	In the present study, we examined the expression of HMW-MAA in 95 paraffin-embedded, primary ALM lesions and 13 primary superficial spreading melanoma (SSM) lesions.	Paraffin	66-74	chondroitin sulfate proteoglycan 4	Homo sapiens	52-59
19596850-0	2009	Ca(2+) signaling evoked by activation of Na(+) channels and Na(+)/Ca(2+) exchangers is required for GABA-induced NG2 cell migration.	gamma-Aminobutyric Acid	100-104	chondroitin sulfate proteoglycan 4	Homo sapiens	113-116
19596850-4	2009	We found that GABA induces membrane depolarization and Ca(2+) elevation in NG2 cells, a process requiring activation of GABA(A) receptors, Na(+) channels, and Na(+)/Ca(2+) exchangers (NCXs), but not Ca(2+) channels.	gamma-Aminobutyric Acid	14-18	chondroitin sulfate proteoglycan 4	Homo sapiens	75-78
20025816-1	2009	It is well established that NG2 cells throughout the young and adult brain consistently detect the release of single vesicles filled with glutamate from nearby axons.	Glutamic Acid	138-147	chondroitin sulfate proteoglycan 4	Homo sapiens	28-31
20025816-2	2009	The released neurotransmitter glutamate electrically excites NG2 cells via non-NMDA (N-methyl-D-aspartic acid) glutamate receptors but the individual contribution of AMPA and kainate receptors to neuron-NG2 cell signalling, is not well understood.	Glutamic Acid	30-39	chondroitin sulfate proteoglycan 4	Homo sapiens	61-64
20025816-2	2009	The released neurotransmitter glutamate electrically excites NG2 cells via non-NMDA (N-methyl-D-aspartic acid) glutamate receptors but the individual contribution of AMPA and kainate receptors to neuron-NG2 cell signalling, is not well understood.	Glutamic Acid	30-39	chondroitin sulfate proteoglycan 4	Homo sapiens	203-206
20025816-7	2009	In addition to this inward current, nanomolar concentrations of kainate also produced a dramatic increase in the frequency of spontaneous GABA-A receptor-mediated synaptic currents (IPSCs) in NG2 cells.	Kainic Acid	64-71	chondroitin sulfate proteoglycan 4	Homo sapiens	192-195
20025816-11	2009	Our data suggest that hippocampal kainate receptors are not only important for communication between neurons but may also play a dual and subtype-specific role for neuron-glia signalling: Firstly, extra-synaptic non-GluR5 kainate receptors in the membrane of NG2 cells are ideally suited to instruct NG2 cells on the population activity of local excitatory neurons via ambient glutamate.	Glutamic Acid	377-386	chondroitin sulfate proteoglycan 4	Homo sapiens	259-262
18677475-15	2009	CONCLUSIONS: HMW-MAA-specific mAb down-regulated P-Pyk2 expression and enhanced the anti-proliferative effect of cytarabine in vitro, but had no detectable effect on survival or growth of leukemia cells in vivo.	Cytarabine	113-123	chondroitin sulfate proteoglycan 4	Homo sapiens	13-20
16365873-6	2006	The C-terminal carbohydrate recognition domain of galectin-3 is responsible for binding to the NG2 core protein.	Carbohydrates	15-27	chondroitin sulfate proteoglycan 4	Homo sapiens	95-98
18560887-5	2008	The majority of the new cells were immunoreactive for NG2 chondroitin sulfate, a marker for specific progenitor cells, but not for NeuN, a neuronal marker.	Chondroitin Sulfates	58-77	chondroitin sulfate proteoglycan 4	Homo sapiens	54-57
17994581-3	2008	We replaced the leucine residues with norleucine residues at the hydrophobic positions in LG2 and LG3, to create NG2 and NG3, respectively.	Norleucine	38-48	chondroitin sulfate proteoglycan 4	Homo sapiens	113-116
17994581-5	2008	NG3 and NG2 were found to be slightly less helical and significantly less stable toward guanidine hydrochloride compared with their reference caviteins.	Guanidine	88-111	chondroitin sulfate proteoglycan 4	Homo sapiens	8-11
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	28-30	chondroitin sulfate proteoglycan 4	Homo sapiens	91-95
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	28-30	chondroitin sulfate proteoglycan 4	Homo sapiens	97-130
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	32-51	chondroitin sulfate proteoglycan 4	Homo sapiens	91-95
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	32-51	chondroitin sulfate proteoglycan 4	Homo sapiens	97-130
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Glycosaminoglycans	53-56	chondroitin sulfate proteoglycan 4	Homo sapiens	91-95
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Glycosaminoglycans	53-56	chondroitin sulfate proteoglycan 4	Homo sapiens	97-130
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Glycosaminoglycans	58-75	chondroitin sulfate proteoglycan 4	Homo sapiens	91-95
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Glycosaminoglycans	58-75	chondroitin sulfate proteoglycan 4	Homo sapiens	97-130
17217338-4	2007	When melanoma cells were treated with betaDX (p-nitro-beta-D-xylopyranoside) to inhibit coupling of CS on the core protein, both active form and proform of MMP-2 were no longer co-immunoprecipitated with either MCSP or MT3-MMP, suggesting a model in which CS directly binds to MMP-2 and presents the gelatinase to MT3-MMP to be activated.	betadx	38-44	chondroitin sulfate proteoglycan 4	Homo sapiens	211-215
17184184-7	2006	NG2(+) cells after SCI displayed altered voltage-gated potassium current profiles compared to normal adult and P7 animals.	Potassium	55-64	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
16407841-1	2006	The human high molecular weight-melanoma associated antigen (HMW-MAA) is a membrane-bound chondroitin sulfate proteoglycan that is variably expressed in a high percentage of melanoma cell lines and tumors.	Chondroitin Sulfates	90-109	chondroitin sulfate proteoglycan 4	Homo sapiens	10-59
16407841-1	2006	The human high molecular weight-melanoma associated antigen (HMW-MAA) is a membrane-bound chondroitin sulfate proteoglycan that is variably expressed in a high percentage of melanoma cell lines and tumors.	Chondroitin Sulfates	90-109	chondroitin sulfate proteoglycan 4	Homo sapiens	61-68
16407841-5	2006	Methylation-specific PCR and sodium bisulfite DNA sequencing analyses indicate that the HMW-MAA promoter is heavily methylated in melanoma cell lines, melanoma lesions and normal lymphocytes that do not express HMW-MAA; in contrast, the HMW-MAA promoter is not methylated in melanoma cell lines and tumors that express this antigen.	sodium bisulfite	29-45	chondroitin sulfate proteoglycan 4	Homo sapiens	88-95
16407841-6	2006	In addition, HMW-MAA expression is markedly induced in HMW-MAA-negative melanoma cell lines by incubation with the DNA methyltransferase inhibitor 5-aza-2"-deoxycytidine.	Decitabine	147-169	chondroitin sulfate proteoglycan 4	Homo sapiens	13-20
16407841-6	2006	In addition, HMW-MAA expression is markedly induced in HMW-MAA-negative melanoma cell lines by incubation with the DNA methyltransferase inhibitor 5-aza-2"-deoxycytidine.	Decitabine	147-169	chondroitin sulfate proteoglycan 4	Homo sapiens	55-62
18337643-5	2008	MCSP-ETA" induced cell death synergistically with cyclosporin A, both in established human melanoma cell lines and cultured primary melanoma cells.	Cyclosporine	50-63	chondroitin sulfate proteoglycan 4	Homo sapiens	0-4
17585905-3	2007	Combining such a prior peripheral nerve conditioning lesion with the infusion of antibodies that neutralize the growth inhibitory effects of the NG2 chondroitin sulfate proteoglycan promotes sensory axon growth through the glial scar and into the white matter of the dorsal columns.	Chondroitin Sulfates	149-168	chondroitin sulfate proteoglycan 4	Homo sapiens	145-148
17591920-1	2007	Two distinct Thr phosphorylation events within the cytoplasmic domain of the NG2 proteoglycan help regulate the cellular balance between proliferation and motility.	Threonine	13-16	chondroitin sulfate proteoglycan 4	Homo sapiens	77-80
17239557-6	2007	It is presumed that these cells release RA in a paracrine fashion in the region of the wound; however, the RALDH2/NG2-immunoreactive cells expressed the retinoid receptors RARalpha, RARbeta, RXRalpha and RXRbeta, suggesting that RA also serves an autocrine function.	Tretinoin	107-109	chondroitin sulfate proteoglycan 4	Homo sapiens	114-117
16365873-8	2006	The interaction between galectin-3 and NG2 is a carbohydrate-dependent one mediated by N-linked rather than O-linked oligosaccharides within the D3 domain of the NG2 core protein.	Carbohydrates	48-60	chondroitin sulfate proteoglycan 4	Homo sapiens	39-42
16365873-8	2006	The interaction between galectin-3 and NG2 is a carbohydrate-dependent one mediated by N-linked rather than O-linked oligosaccharides within the D3 domain of the NG2 core protein.	Carbohydrates	48-60	chondroitin sulfate proteoglycan 4	Homo sapiens	162-165
16365873-8	2006	The interaction between galectin-3 and NG2 is a carbohydrate-dependent one mediated by N-linked rather than O-linked oligosaccharides within the D3 domain of the NG2 core protein.	n-linked rather than o-linked oligosaccharides	87-133	chondroitin sulfate proteoglycan 4	Homo sapiens	39-42
16365873-8	2006	The interaction between galectin-3 and NG2 is a carbohydrate-dependent one mediated by N-linked rather than O-linked oligosaccharides within the D3 domain of the NG2 core protein.	n-linked rather than o-linked oligosaccharides	87-133	chondroitin sulfate proteoglycan 4	Homo sapiens	162-165
15924863-2	2005	Here, we show that release of glutamate from climbing fiber (CF) axons produces AMPA receptor currents with rapid kinetics in these NG2-immunoreactive glial cells (NG2+ cells) in cerebellar slices.	Glutamic Acid	30-39	chondroitin sulfate proteoglycan 4	Homo sapiens	132-135
16691121-5	2006	The data demonstrate that NG2 levels rise significantly between 3 and 7 days postinjury (dpi) and remain elevated chronically throughout the lesions.	3-aminodiphenyleneiodium	89-92	chondroitin sulfate proteoglycan 4	Homo sapiens	26-29
16253523-6	2006	Comparisons of Gd-DTPA-BMA and Gadomer revealed differences in their spatial distribution in the U251-NG2 and U251-WT tumours.	Gadolinium DTPA	15-22	chondroitin sulfate proteoglycan 4	Homo sapiens	102-105
16253523-6	2006	Comparisons of Gd-DTPA-BMA and Gadomer revealed differences in their spatial distribution in the U251-NG2 and U251-WT tumours.	bma	23-26	chondroitin sulfate proteoglycan 4	Homo sapiens	102-105
15949494-5	2005	A complex is formed between GRIP, NG2 and the AMPA class of glutamate receptors: this may position these glial receptors towards sites of neuronal glutamate release at synapses and during myelination.	Glutamic Acid	60-69	chondroitin sulfate proteoglycan 4	Homo sapiens	34-37
15924863-2	2005	Here, we show that release of glutamate from climbing fiber (CF) axons produces AMPA receptor currents with rapid kinetics in these NG2-immunoreactive glial cells (NG2+ cells) in cerebellar slices.	Glutamic Acid	30-39	chondroitin sulfate proteoglycan 4	Homo sapiens	164-167
15252819-4	2004	Two recent reports show that a ubiquitous class of progenitors that express the proteoglycan NG2 (NG2 cells) engage in rapid signaling with glutamatergic and gamma-aminobutyric acid (GABA)ergic neurons through direct neuron-glia synapses.	gamma-Aminobutyric Acid	158-181	chondroitin sulfate proteoglycan 4	Homo sapiens	93-96
15504744-1	2004	Protein kinase C (PKC)-alpha phosphorylation of recombinant NG2 cytoplasmic domain and phorbol ester-induced PKC-dependent phosphorylation of full-length NG2 expressed in U251 cells are both blocked by mutation of Thr(2256), identifying this residue as a primary phosphorylation site.	Phorbol Esters	87-100	chondroitin sulfate proteoglycan 4	Homo sapiens	154-157
15504744-1	2004	Protein kinase C (PKC)-alpha phosphorylation of recombinant NG2 cytoplasmic domain and phorbol ester-induced PKC-dependent phosphorylation of full-length NG2 expressed in U251 cells are both blocked by mutation of Thr(2256), identifying this residue as a primary phosphorylation site.	Threonine	214-217	chondroitin sulfate proteoglycan 4	Homo sapiens	60-63
15504744-1	2004	Protein kinase C (PKC)-alpha phosphorylation of recombinant NG2 cytoplasmic domain and phorbol ester-induced PKC-dependent phosphorylation of full-length NG2 expressed in U251 cells are both blocked by mutation of Thr(2256), identifying this residue as a primary phosphorylation site.	Threonine	214-217	chondroitin sulfate proteoglycan 4	Homo sapiens	154-157
15504744-4	2004	U251 cells expressing NG2 with a valine substitution at position 2256 are resistant to phorbol ester treatment: NG2 remains in membrane protrusions and cell motility is unchanged.	Valine	33-39	chondroitin sulfate proteoglycan 4	Homo sapiens	22-25
15504744-4	2004	U251 cells expressing NG2 with a valine substitution at position 2256 are resistant to phorbol ester treatment: NG2 remains in membrane protrusions and cell motility is unchanged.	Valine	33-39	chondroitin sulfate proteoglycan 4	Homo sapiens	112-115
15504744-4	2004	U251 cells expressing NG2 with a valine substitution at position 2256 are resistant to phorbol ester treatment: NG2 remains in membrane protrusions and cell motility is unchanged.	Phorbol Esters	87-100	chondroitin sulfate proteoglycan 4	Homo sapiens	22-25
15504744-4	2004	U251 cells expressing NG2 with a valine substitution at position 2256 are resistant to phorbol ester treatment: NG2 remains in membrane protrusions and cell motility is unchanged.	Phorbol Esters	87-100	chondroitin sulfate proteoglycan 4	Homo sapiens	112-115
15504744-5	2004	In contrast, NG2 with a glutamic acid substitution at position 2256 redistributes to lamellipodia even without phorbol ester treatment, rendering transfected U251 cells spontaneously motile.	Glutamic Acid	24-37	chondroitin sulfate proteoglycan 4	Homo sapiens	13-16
15504744-5	2004	In contrast, NG2 with a glutamic acid substitution at position 2256 redistributes to lamellipodia even without phorbol ester treatment, rendering transfected U251 cells spontaneously motile.	Phorbol Esters	111-124	chondroitin sulfate proteoglycan 4	Homo sapiens	13-16
15504744-6	2004	PKC-alpha-mediated NG2 phosphorylation at Thr(2256) is therefore a key step for initiating cell polarization and motility.	Threonine	42-45	chondroitin sulfate proteoglycan 4	Homo sapiens	19-22
15534596-8	2004	Oligodendrocytes, astrocytes, and NG2-glia all contact axons at nodes of Ranvier and respond to glutamate, ATP, and potassium released during axonal electrical activity.	Glutamic Acid	96-105	chondroitin sulfate proteoglycan 4	Homo sapiens	34-37
15534596-8	2004	Oligodendrocytes, astrocytes, and NG2-glia all contact axons at nodes of Ranvier and respond to glutamate, ATP, and potassium released during axonal electrical activity.	Adenosine Triphosphate	107-110	chondroitin sulfate proteoglycan 4	Homo sapiens	34-37
15534596-8	2004	Oligodendrocytes, astrocytes, and NG2-glia all contact axons at nodes of Ranvier and respond to glutamate, ATP, and potassium released during axonal electrical activity.	Potassium	116-125	chondroitin sulfate proteoglycan 4	Homo sapiens	34-37
15326615-3	2004	Acute bromodeoxyuridine (BrdU) labeling studies revealed a 4- to 6-fold increase in NG2(+) cell proliferation in shi spinal cord between postnatal day18 (P18) and P60, and most BrdU(+) cells were NG2(+) after P18.	Bromodeoxyuridine	6-23	chondroitin sulfate proteoglycan 4	Homo sapiens	84-87
15326615-3	2004	Acute bromodeoxyuridine (BrdU) labeling studies revealed a 4- to 6-fold increase in NG2(+) cell proliferation in shi spinal cord between postnatal day18 (P18) and P60, and most BrdU(+) cells were NG2(+) after P18.	Bromodeoxyuridine	25-29	chondroitin sulfate proteoglycan 4	Homo sapiens	84-87
15252819-4	2004	Two recent reports show that a ubiquitous class of progenitors that express the proteoglycan NG2 (NG2 cells) engage in rapid signaling with glutamatergic and gamma-aminobutyric acid (GABA)ergic neurons through direct neuron-glia synapses.	gamma-Aminobutyric Acid	158-181	chondroitin sulfate proteoglycan 4	Homo sapiens	98-101
15252819-4	2004	Two recent reports show that a ubiquitous class of progenitors that express the proteoglycan NG2 (NG2 cells) engage in rapid signaling with glutamatergic and gamma-aminobutyric acid (GABA)ergic neurons through direct neuron-glia synapses.	gamma-Aminobutyric Acid	183-187	chondroitin sulfate proteoglycan 4	Homo sapiens	93-96
15252819-4	2004	Two recent reports show that a ubiquitous class of progenitors that express the proteoglycan NG2 (NG2 cells) engage in rapid signaling with glutamatergic and gamma-aminobutyric acid (GABA)ergic neurons through direct neuron-glia synapses.	gamma-Aminobutyric Acid	183-187	chondroitin sulfate proteoglycan 4	Homo sapiens	98-101
15252819-5	2004	Quantal release of transmitter from neurons at these sites triggers rapid activation of aminomethylisoxazole propionic acid (AMPA) or GABA(A) receptors in NG2 cells.	aminomethylisoxazole propionic acid	88-123	chondroitin sulfate proteoglycan 4	Homo sapiens	155-158
15252819-8	2004	The ability of both glutamate and GABA to influence the morphology, physiology, and development of NG2 cells in vitro suggests that this rapid form of signaling may play important roles in adapting the behavior of these cells to the needs of surrounding neurons in vivo.	Glutamic Acid	20-29	chondroitin sulfate proteoglycan 4	Homo sapiens	99-102
15252819-8	2004	The ability of both glutamate and GABA to influence the morphology, physiology, and development of NG2 cells in vitro suggests that this rapid form of signaling may play important roles in adapting the behavior of these cells to the needs of surrounding neurons in vivo.	gamma-Aminobutyric Acid	34-38	chondroitin sulfate proteoglycan 4	Homo sapiens	99-102
15588226-0	2004	Human high molecular weight-melanoma-associated antigen (HMW-MAA): a melanoma cell surface chondroitin sulfate proteoglycan (MSCP) with biological and clinical significance.	Chondroitin Sulfates	91-110	chondroitin sulfate proteoglycan 4	Homo sapiens	6-55
15588226-0	2004	Human high molecular weight-melanoma-associated antigen (HMW-MAA): a melanoma cell surface chondroitin sulfate proteoglycan (MSCP) with biological and clinical significance.	Chondroitin Sulfates	91-110	chondroitin sulfate proteoglycan 4	Homo sapiens	57-64
10889192-1	2000	Interactions of the developmentally regulated chondroitin sulfate proteoglycan NG2 with human plasminogen and kringle domain-containing plasminogen fragments have been analyzed by solid-phase immunoassays and by surface plasmon resonance.	Chondroitin Sulfates	46-65	chondroitin sulfate proteoglycan 4	Homo sapiens	79-82
12514214-2	2003	The extracellular domain of the NG2 core protein contains three subdomains: an N-terminal globular domain (domain 1), a central extended domain that has the sites for glycosaminoglycan (GAG) attachment (domain 2), and a juxtamembrane domain (domain 3).	Glycosaminoglycans	167-184	chondroitin sulfate proteoglycan 4	Homo sapiens	32-35
12514214-2	2003	The extracellular domain of the NG2 core protein contains three subdomains: an N-terminal globular domain (domain 1), a central extended domain that has the sites for glycosaminoglycan (GAG) attachment (domain 2), and a juxtamembrane domain (domain 3).	Glycosaminoglycans	186-189	chondroitin sulfate proteoglycan 4	Homo sapiens	32-35
11493670-0	2001	Chondroitin sulfate and cytoplasmic domain-dependent membrane targeting of the NG2 proteoglycan promotes retraction fiber formation and cell polarization.	Chondroitin Sulfates	0-19	chondroitin sulfate proteoglycan 4	Homo sapiens	79-82
11493670-2	2001	Both the cytoplasmic domain and the chondroitin sulfate chain of NG2 appear to have roles in sorting NG2 to subcellular microdomains destined to become retraction fibers.	Chondroitin Sulfates	36-55	chondroitin sulfate proteoglycan 4	Homo sapiens	65-68
11493670-2	2001	Both the cytoplasmic domain and the chondroitin sulfate chain of NG2 appear to have roles in sorting NG2 to subcellular microdomains destined to become retraction fibers.	Chondroitin Sulfates	36-55	chondroitin sulfate proteoglycan 4	Homo sapiens	101-104
14501222-9	2002	Although the presence of Ca2+ permeable AMPA receptors provides a pathway to link neuronal activity to Ca2+ dependent processes within the NG2 cells, these receptors also put these cells at risk for glutamate-associated excitotoxicity.	Glutamic Acid	199-208	chondroitin sulfate proteoglycan 4	Homo sapiens	139-142
11278606-5	2001	The association between MT3-MMP and MCSP was largely disrupted by removing chondroitin sulfate glycosaminoglycan (CS) from the cell surface, suggesting CS could mediate the association between the two cell surface core proteins.	chondroitin sulfate glycosaminoglycan	75-112	chondroitin sulfate proteoglycan 4	Homo sapiens	36-40
11278606-5	2001	The association between MT3-MMP and MCSP was largely disrupted by removing chondroitin sulfate glycosaminoglycan (CS) from the cell surface, suggesting CS could mediate the association between the two cell surface core proteins.	chondroitin sulfate glycosaminoglycan	114-116	chondroitin sulfate proteoglycan 4	Homo sapiens	36-40
10889192-5	2000	Inhibition of plasminogen and angiostatin binding to NG2 by 6-aminohexanoic acid suggests that lysine binding sites are involved in kringle interaction with NG2.	Aminocaproic Acid	60-80	chondroitin sulfate proteoglycan 4	Homo sapiens	53-56
10889192-5	2000	Inhibition of plasminogen and angiostatin binding to NG2 by 6-aminohexanoic acid suggests that lysine binding sites are involved in kringle interaction with NG2.	Lysine	95-101	chondroitin sulfate proteoglycan 4	Homo sapiens	53-56
10889192-5	2000	Inhibition of plasminogen and angiostatin binding to NG2 by 6-aminohexanoic acid suggests that lysine binding sites are involved in kringle interaction with NG2.	Lysine	95-101	chondroitin sulfate proteoglycan 4	Homo sapiens	157-160
10967549-1	2000	A yeast two-hybrid screen was employed to identify ligands for the cytoplasmic domain of the NG2 chondroitin sulfate proteoglycan.	Chondroitin Sulfates	97-116	chondroitin sulfate proteoglycan 4	Homo sapiens	93-96
10029083-5	1999	We screened the amino acid sequence of the MCSP molecule for a region of homology to the consensus sequence and found that the amino acid sequence Val-His-Ile-Asn-Ala-His spanning positions 289 and 294 has high homology.	H-Val-His-OH	147-154	chondroitin sulfate proteoglycan 4	Homo sapiens	43-47
10737389-7	2000	Similarly, SK-mel-29 melanoma cells were also efficiently lysed by HLA-A2/gag-specific CTL when HLA-A2/gag complexes were linked to their surface via the HMW-MAA specific anti-melanoma antibody 225.28s.	Glycosaminoglycans	74-77	chondroitin sulfate proteoglycan 4	Homo sapiens	154-161
10587647-4	1999	Here we show that stimulated MCSP recruits tyrosine-phosphorylated p130 cas, an adaptor protein important in tumour cell motility and invasion.	Tyrosine	43-51	chondroitin sulfate proteoglycan 4	Homo sapiens	29-33
10587647-6	1999	MCSP-induced spreading of melanoma cells is dependent upon active Cdc42, a Cdc42-associated tyrosine kinase (Ack-1) and tyrosine phosphorylation of p130cas.	Tyrosine	92-100	chondroitin sulfate proteoglycan 4	Homo sapiens	0-4
10587647-7	1999	Furthermore, vectors inhibiting Ack-1 or Cdc42 expression and/or function abrogate MCSP-induced tyrosine phosphorylation and recruitment of p130cas.	Tyrosine	96-104	chondroitin sulfate proteoglycan 4	Homo sapiens	83-87
10587647-8	1999	Our findings indicate that MCSP may modify tumour growth or invasion by a unique signal-transduction pathway that links Cdc42 activation to downstream tyrosine phosphorylation and subsequent cytoskeletal reorganization.	Tyrosine	151-159	chondroitin sulfate proteoglycan 4	Homo sapiens	27-31
10457372-1	1999	The expression of NG2 chondroitin sulfate has been widely associated with oligodendrocyte precursors in rodents.	Chondroitin Sulfates	22-41	chondroitin sulfate proteoglycan 4	Homo sapiens	18-21
10737389-7	2000	Similarly, SK-mel-29 melanoma cells were also efficiently lysed by HLA-A2/gag-specific CTL when HLA-A2/gag complexes were linked to their surface via the HMW-MAA specific anti-melanoma antibody 225.28s.	Glycosaminoglycans	103-106	chondroitin sulfate proteoglycan 4	Homo sapiens	154-161
10583275-5	1999	These data demonstrate that, if NG2 expression in AL is the (in)direct result of MLL rearrangement, such activation is restricted to a monoblastic population in AML.	Aluminum	50-52	chondroitin sulfate proteoglycan 4	Homo sapiens	32-35
10571405-1	1999	The expression and function of NG2, a transmembrane chondroitin sulfate proteoglycan was studied in human gliomas of various histological types in culture using immunocytochemistry and flow cytometry.	Chondroitin Sulfates	52-71	chondroitin sulfate proteoglycan 4	Homo sapiens	31-34
10029083-5	1999	We screened the amino acid sequence of the MCSP molecule for a region of homology to the consensus sequence and found that the amino acid sequence Val-His-Ile-Asn-Ala-His spanning positions 289 and 294 has high homology.	Isoleucine	155-158	chondroitin sulfate proteoglycan 4	Homo sapiens	43-47
10029083-5	1999	We screened the amino acid sequence of the MCSP molecule for a region of homology to the consensus sequence and found that the amino acid sequence Val-His-Ile-Asn-Ala-His spanning positions 289 and 294 has high homology.	Asparagine	159-162	chondroitin sulfate proteoglycan 4	Homo sapiens	43-47
10029083-5	1999	We screened the amino acid sequence of the MCSP molecule for a region of homology to the consensus sequence and found that the amino acid sequence Val-His-Ile-Asn-Ala-His spanning positions 289 and 294 has high homology.	Alanine	163-166	chondroitin sulfate proteoglycan 4	Homo sapiens	43-47
10029083-5	1999	We screened the amino acid sequence of the MCSP molecule for a region of homology to the consensus sequence and found that the amino acid sequence Val-His-Ile-Asn-Ala-His spanning positions 289 and 294 has high homology.	Histidine	151-154	chondroitin sulfate proteoglycan 4	Homo sapiens	43-47
9671962-2	1998	Previous studies have demonstrated that these unusual glial cells, which can be identified by virtue of their expression of the NG2 chondroitin sulfate proteoglycan, react to traumatic brain injury.	Chondroitin Sulfates	132-151	chondroitin sulfate proteoglycan 4	Homo sapiens	128-131
10197164-12	1998	CONCLUSION: NG2/HMPG is expressed by human fetal and adult chondrocytes and in adult articular chondrocytes the core protein is chondroitin sulfated.	chondroitin sulfate D	128-148	chondroitin sulfate proteoglycan 4	Homo sapiens	12-15
9622083-8	1998	Furthermore, like some mouse mAbs, human scFvs react with rat neural cells expressing the chondroitin sulfate proteoglycan NG2, which shows 81% homology to the HMW-MAA.	Chondroitin Sulfates	90-109	chondroitin sulfate proteoglycan 4	Homo sapiens	160-167
9622083-12	1998	In contrast to mouse mAb, scFv 61 immunoprecipitates the >450-kDa chondroitin sulfate proteoglycan component of the HMW-MAA, but not its 250-kDa subunit from melanoma cells.	Chondroitin Sulfates	69-88	chondroitin sulfate proteoglycan 4	Homo sapiens	119-126
9117258-1	1996	In this review, we discuss the properties of the NG2 chondroitin sulfate proteoglycan, a structurally unique, integral membrane proteoglycan that is found on the surfaces of several different types of immature cells.	Chondroitin Sulfates	53-72	chondroitin sulfate proteoglycan 4	Homo sapiens	49-52
9099729-4	1997	Consistent with previous models of glycosaminoglycan attachment, roughly 50% of the recombinant NG2 fragments containing the central domain have chondroitin sulfate chains attached to the protein core.	Glycosaminoglycans	35-52	chondroitin sulfate proteoglycan 4	Homo sapiens	96-99
9099729-4	1997	Consistent with previous models of glycosaminoglycan attachment, roughly 50% of the recombinant NG2 fragments containing the central domain have chondroitin sulfate chains attached to the protein core.	Chondroitin Sulfates	145-164	chondroitin sulfate proteoglycan 4	Homo sapiens	96-99
8568901-2	1996	mAb GH1002 was elicited with the syngeneic anti-idiotype mAb MK2-23 which mimics the determinant defined by anti-human high molecular weight-melanoma associated antigen (HMW-MAA) mAb 763.74.	gh1002	4-10	chondroitin sulfate proteoglycan 4	Homo sapiens	119-168
8568901-2	1996	mAb GH1002 was elicited with the syngeneic anti-idiotype mAb MK2-23 which mimics the determinant defined by anti-human high molecular weight-melanoma associated antigen (HMW-MAA) mAb 763.74.	gh1002	4-10	chondroitin sulfate proteoglycan 4	Homo sapiens	170-177
8970159-4	1996	On poly-L-lysine-coated dishes, cell surface NG2 is associated with radial processes extending from the cell periphery.	Lysine	3-16	chondroitin sulfate proteoglycan 4	Homo sapiens	45-48
8970159-5	1996	Spreading on fibronectin/poly-L-lysine mixtures, as well as on matrix components such as laminin, tenascin, and type VI collagen, produces cells with mosaic characteristics, i.e., NG2 is associated with both types of structures.	Lysine	25-38	chondroitin sulfate proteoglycan 4	Homo sapiens	180-183
8562939-1	1996	Monoclonal antibody 7.1, which recognizes the chondroitin sulfate proteoglycan molecule NG2, was used to screen prospectively blast cells from 104 consecutive children at initial presentation with acute lymphoblastic leukemia (ALL).	Chondroitin Sulfates	46-65	chondroitin sulfate proteoglycan 4	Homo sapiens	88-91
7590776-4	1995	Anti-id MAb MK2-23 induced humoral anti-HMW-MAA immunity in about 60% of the immunized patients.	mk2-23	12-18	chondroitin sulfate proteoglycan 4	Homo sapiens	40-47