PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32123287-0	2020	PROM2 promotes gemcitabine chemoresistance via activating the Akt signaling pathway in pancreatic cancer.	gemcitabine	15-26	prominin 2	Homo sapiens	0-5
32123287-6	2020	We provide evidence that PROM2 promotes chemoresistance to gemcitabine both in vivo and in vitro.	gemcitabine	59-70	prominin 2	Homo sapiens	25-30
32123287-7	2020	Mechanistically, we demonstrate that PROM2 could directly interacted with Akt and activates the Akt signaling pathway, which thus inhibiting gemcitabine-induced apoptosis.	gemcitabine	141-152	prominin 2	Homo sapiens	37-42
32123287-8	2020	As further evidence, we show PROM2 expression and Akt phosphorylation both promote gemcitabine chemoresistance, and cause poorer survival in clinical samples with pancreatic cancer.	gemcitabine	83-94	prominin 2	Homo sapiens	29-34
32123287-10	2020	Our findings not only establish PROM2 as a novel positive regulator of the Akt signaling pathway and a candidate prognostic indicator of gemcitabine response, but also provide a neo-therapeutic approach for patients resistant to gemcitabine treatment.	gemcitabine	137-148	prominin 2	Homo sapiens	32-37
32123287-10	2020	Our findings not only establish PROM2 as a novel positive regulator of the Akt signaling pathway and a candidate prognostic indicator of gemcitabine response, but also provide a neo-therapeutic approach for patients resistant to gemcitabine treatment.	gemcitabine	229-240	prominin 2	Homo sapiens	32-37
31735663-0	2019	Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export.	Iron	55-59	prominin 2	Homo sapiens	0-9
31735663-5	2019	Mechanistically, prominin2 promotes the formation of ferritin-containing multivesicular bodies (MVBs) and exosomes that transport iron out of the cell, inhibiting ferroptosis.	Iron	130-134	prominin 2	Homo sapiens	17-26
31735663-6	2019	These findings reveal that ferroptosis resistance can be driven by a prominin2-MVB-exosome-ferritin pathway and have broad implications for iron homeostasis, intracellular trafficking, and cancer.	Iron	140-144	prominin 2	Homo sapiens	69-78
25906737-0	2015	Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation.	diproline	62-71	prominin 2	Homo sapiens	40-46
25906737-1	2015	With the aim of developing polyproline type II helix (PPII) secondary-structure mimetics for the modulation of prolin-rich-mediated protein-protein interactions, the novel diproline mimetic ProM-2 was designed by bridging the two pyrrolidine rings of a diproline (Pro-Pro) unit through a Z-vinylidene moiety.	polyproline	27-38	prominin 2	Homo sapiens	190-196
25906737-1	2015	With the aim of developing polyproline type II helix (PPII) secondary-structure mimetics for the modulation of prolin-rich-mediated protein-protein interactions, the novel diproline mimetic ProM-2 was designed by bridging the two pyrrolidine rings of a diproline (Pro-Pro) unit through a Z-vinylidene moiety.	diproline	172-181	prominin 2	Homo sapiens	190-196
25906737-1	2015	With the aim of developing polyproline type II helix (PPII) secondary-structure mimetics for the modulation of prolin-rich-mediated protein-protein interactions, the novel diproline mimetic ProM-2 was designed by bridging the two pyrrolidine rings of a diproline (Pro-Pro) unit through a Z-vinylidene moiety.	pyrrolidine	230-241	prominin 2	Homo sapiens	190-196
25906737-1	2015	With the aim of developing polyproline type II helix (PPII) secondary-structure mimetics for the modulation of prolin-rich-mediated protein-protein interactions, the novel diproline mimetic ProM-2 was designed by bridging the two pyrrolidine rings of a diproline (Pro-Pro) unit through a Z-vinylidene moiety.	diproline	253-262	prominin 2	Homo sapiens	190-196
25906737-1	2015	With the aim of developing polyproline type II helix (PPII) secondary-structure mimetics for the modulation of prolin-rich-mediated protein-protein interactions, the novel diproline mimetic ProM-2 was designed by bridging the two pyrrolidine rings of a diproline (Pro-Pro) unit through a Z-vinylidene moiety.	Pro-Pro	264-271	prominin 2	Homo sapiens	190-196
25906737-1	2015	With the aim of developing polyproline type II helix (PPII) secondary-structure mimetics for the modulation of prolin-rich-mediated protein-protein interactions, the novel diproline mimetic ProM-2 was designed by bridging the two pyrrolidine rings of a diproline (Pro-Pro) unit through a Z-vinylidene moiety.	z-vinylidene	288-300	prominin 2	Homo sapiens	190-196
32391424-2	2020	We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.	Iron	78-82	prominin 2	Homo sapiens	58-67
32391424-2	2020	We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.	Iron	151-155	prominin 2	Homo sapiens	58-67
32391424-2	2020	We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.	Iron	151-155	prominin 2	Homo sapiens	58-67