PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 24512852-0 2013 Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic beta-cells. Palmitates 0-9 zinc finger protein 148 Homo sapiens 51-56 28072746-7 2017 Correlation analysis demonstrated that levels of ZNF148 mRNA were negatively associated with levels of miR144, miR335, and miR365. mir365 123-129 zinc finger protein 148 Homo sapiens 49-55 24396871-0 2013 Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic beta-cells. Palmitates 0-9 zinc finger protein 148 Homo sapiens 51-56 24396871-4 2013 Chromatin immunoprecipitation, transient transfection and siRNA-mediated knockdown assays revealed that palmitate induced Nur77 promoter activation involves Sp1 recruitment and ZBP89 release from the gene promoter. Palmitates 104-113 zinc finger protein 148 Homo sapiens 177-182 24512852-4 2013 Chromatin immunoprecipitation, transient transfection and siRNA-mediated knockdown assays revealed that palmitate induced Nur77 promoter activation involves Sp1 recruitment and ZBP89 release from the gene promoter. Palmitates 104-113 zinc finger protein 148 Homo sapiens 177-182 22214764-5 2012 Overexpression of ZBP-89 protein enhanced the lethal effectiveness of Trichostatin A (TSA). trichostatin A 70-84 zinc finger protein 148 Homo sapiens 18-24 22111549-11 2012 Reporter gene analysis showed a significant up-regulation of basal promoter activity by co-transfection with ZBP-89, which could be abolished by mithramycin treatment. Plicamycin 145-156 zinc finger protein 148 Homo sapiens 109-115 22214764-5 2012 Overexpression of ZBP-89 protein enhanced the lethal effectiveness of Trichostatin A (TSA). trichostatin A 86-89 zinc finger protein 148 Homo sapiens 18-24 22214764-8 2012 Functionally, the cytoplasmic accumulation of ZBP-89 by p53(G245D) significantly abrogated the induction of p21 caused by sodium butyrate (NaB) treatment and protected cells from TSA-induced death. Butyric Acid 122-137 zinc finger protein 148 Homo sapiens 46-52 22214764-8 2012 Functionally, the cytoplasmic accumulation of ZBP-89 by p53(G245D) significantly abrogated the induction of p21 caused by sodium butyrate (NaB) treatment and protected cells from TSA-induced death. nab 139-142 zinc finger protein 148 Homo sapiens 46-52 22214764-8 2012 Functionally, the cytoplasmic accumulation of ZBP-89 by p53(G245D) significantly abrogated the induction of p21 caused by sodium butyrate (NaB) treatment and protected cells from TSA-induced death. trichostatin A 179-182 zinc finger protein 148 Homo sapiens 46-52 20230874-6 2010 In addition, ZBP-89 potentiates in butyrate-induced endogenous p21(waf1) up-regulation. Butyrates 35-43 zinc finger protein 148 Homo sapiens 13-19 19362768-7 2009 With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells. Fluorouracil 99-113 zinc finger protein 148 Homo sapiens 46-52 19362768-7 2009 With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells. Staurosporine 117-130 zinc finger protein 148 Homo sapiens 46-52 15736967-1 2005 Human tryptase-beta (HTbeta) is a serine protease with an atypical tetrameric structure and an unusual dependence on heparin binding or high salt for functional and structural stability. Heparin 117-124 zinc finger protein 148 Homo sapiens 6-28 16825291-9 2006 Mutational analyses of the two ZBP-89 binding sites revealed that both the sites are essential for palmitic acid"s inhibitory effect on the L2 promoter and for the enhancing effect of ZBP-89 on palmitic acid-induced inhibition of the L2 promoter. Palmitic Acid 99-112 zinc finger protein 148 Homo sapiens 31-37 16825291-9 2006 Mutational analyses of the two ZBP-89 binding sites revealed that both the sites are essential for palmitic acid"s inhibitory effect on the L2 promoter and for the enhancing effect of ZBP-89 on palmitic acid-induced inhibition of the L2 promoter. Palmitic Acid 194-207 zinc finger protein 148 Homo sapiens 31-37 16825291-9 2006 Mutational analyses of the two ZBP-89 binding sites revealed that both the sites are essential for palmitic acid"s inhibitory effect on the L2 promoter and for the enhancing effect of ZBP-89 on palmitic acid-induced inhibition of the L2 promoter. Palmitic Acid 194-207 zinc finger protein 148 Homo sapiens 184-190 18496767-5 2009 Using in vitro binding assays we have demonstrated that transcription factors Sp3, ZBP-89 and NF-Y are capable of binding to the SOX18 promoter region spanning the sequence -200 to -162 relative to ATG and that formation of complexes could be efficiently reduced by mithramycin A. mithramycin A 266-279 zinc finger protein 148 Homo sapiens 83-89 17560543-0 2007 ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. Butyrates 71-79 zinc finger protein 148 Homo sapiens 19-25 17560543-5 2007 Disruption of the ATM phosphorylation motif (202)SQ within the zinc finger domain of ZBP-89 attenuated its ability to enhance p21(waf1) activation by butyrate. Butyrates 150-158 zinc finger protein 148 Homo sapiens 85-91 17560543-6 2007 Moreover, disruption of the ATM phosphorylation site abrogated the ability of ZBP-89 to potentiate butyrate induction of endogenous p21(waf1) expression. Butyrates 99-107 zinc finger protein 148 Homo sapiens 78-84 16827139-7 2006 ZBP-89 potentiated p53-mediated cell death with 10 nM staurosporine and 100 nM etoposide, but did not in the presence of the R273H p53 mutation. Staurosporine 54-67 zinc finger protein 148 Homo sapiens 0-6 16827139-7 2006 ZBP-89 potentiated p53-mediated cell death with 10 nM staurosporine and 100 nM etoposide, but did not in the presence of the R273H p53 mutation. Etoposide 79-88 zinc finger protein 148 Homo sapiens 0-6 15736967-1 2005 Human tryptase-beta (HTbeta) is a serine protease with an atypical tetrameric structure and an unusual dependence on heparin binding or high salt for functional and structural stability. Salts 141-145 zinc finger protein 148 Homo sapiens 6-28 15736967-2 2005 In the absence of heparin and at physiological salt, pH, and temperature, HTbeta rapidly loses activity by a reversible process that we have called spontaneous inactivation. Salts 47-51 zinc finger protein 148 Homo sapiens 74-80 15736967-4 2005 Using small irreversible or competitive inhibitors of HTbeta as stabilizing ligands, we were able to examine tetramer stability under inactivating (decay) conditions in the absence of heparin and to define further the process of spontaneous inactivation. Heparin 184-191 zinc finger protein 148 Homo sapiens 54-60 15736967-8 2005 At high concentrations of si-HTbeta (4-5 microM), the binding of inhibitor alone provided sufficient free energy for complete reactivation and tetramer stabilization, whereas at low si-HTbeta concentration (0.1 microM) where the destabilized tetramer would be mostly dissociated, reactivation required more free energy which was provided by the binding of both an inhibitor and heparin. Heparin 378-385 zinc finger protein 148 Homo sapiens 29-35 10899165-0 2000 Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells. Butyrates 82-90 zinc finger protein 148 Homo sapiens 0-27 14963412-4 2004 ZBP-89-induced apoptosis was markedly enhanced by ERK inhibition with U0126. U 0126 70-75 zinc finger protein 148 Homo sapiens 0-6 12840224-5 2003 We sought to determine whether ZBP-89 is a target of p300 during butyrate induction of p21(Waf1). Butyrates 65-73 zinc finger protein 148 Homo sapiens 31-37 12840224-6 2003 This review summarizes the evidence that supports a crucial role for ZBP-89 in butyrate regulation of p21(Waf1). Butyrates 79-87 zinc finger protein 148 Homo sapiens 69-75 12840224-7 2003 Adenovirus-mediated expression of ZBP-89 in HT-29 cells reveals that ZBP-89 potentiates butyrate induction of endogenous p21(Waf1) gene expression. Butyrates 88-96 zinc finger protein 148 Homo sapiens 34-40 12840224-7 2003 Adenovirus-mediated expression of ZBP-89 in HT-29 cells reveals that ZBP-89 potentiates butyrate induction of endogenous p21(Waf1) gene expression. Butyrates 88-96 zinc finger protein 148 Homo sapiens 69-75 12840224-15 2003 Overall, ZBP-89 is a butyrate-regulated coactivator of p53 and is able to induce p21(Waf1) gene expression through both p53-dependent and -independent mechanisms to inhibit cell growth. Butyrates 21-29 zinc finger protein 148 Homo sapiens 9-15 12393719-6 2003 Overexpression of ZBP-89 in the monocyte precursor cell line U937 reduced CD11b promoter-driven luciferase activity when U937 cells were induced to differentiate into monocytelike cells using phorbol esters. Phorbol Esters 192-206 zinc finger protein 148 Homo sapiens 18-24 12622418-4 2002 A variety of extracellular regulators including TGFbeta, retinoic acid and butyrate stimulate ZBP-89 gene expression. Tretinoin 57-70 zinc finger protein 148 Homo sapiens 94-100 12622418-4 2002 A variety of extracellular regulators including TGFbeta, retinoic acid and butyrate stimulate ZBP-89 gene expression. Butyrates 75-83 zinc finger protein 148 Homo sapiens 94-100 12622418-5 2002 Butyrate activation of p21WAF1 is potentiated by ZBP-89 through the recruitment of the co-activator p300, while chronic stimulation by butyrate increases ZBP-89 gene expression correlating with cell differentiation. Butyrates 0-8 zinc finger protein 148 Homo sapiens 49-55 12622418-5 2002 Butyrate activation of p21WAF1 is potentiated by ZBP-89 through the recruitment of the co-activator p300, while chronic stimulation by butyrate increases ZBP-89 gene expression correlating with cell differentiation. Butyrates 135-143 zinc finger protein 148 Homo sapiens 154-160 10899165-11 2000 Deletion of the N-terminal domain of ZBP-89 abolished the potentiation mediated by butyrate treatment. Butyrates 83-91 zinc finger protein 148 Homo sapiens 37-43 10899165-15 2000 Together, these findings demonstrate that ZBP-89 also plays a critical role in butyrate activation of the p21(waf1) promoter and reveals preferential cooperation of this four-zinc finger transcription factor with p300. Butyrates 79-87 zinc finger protein 148 Homo sapiens 42-48 14750171-6 2004 NaB stimulated recruitment of the transcription factors ZBP89 and Sp1 as well as GCN5, but did not influence recruitment of Sp3, HDAC1, p300, or CBP. nab 0-3 zinc finger protein 148 Homo sapiens 56-61 10899165-4 2000 This study sought to determine whether ZBP-89 rather than Sp1 is the direct target of p300 during butyrate induction of p21(waf1). Butyrates 98-106 zinc finger protein 148 Homo sapiens 39-45 10899165-6 2000 Adenoviral-mediated expression of ZBP-89 in HT-29 cells revealed that ZBP-89 potentiates butyrate induction of endogenous p21(waf1) gene expression. Butyrates 89-97 zinc finger protein 148 Homo sapiens 34-40 10899165-6 2000 Adenoviral-mediated expression of ZBP-89 in HT-29 cells revealed that ZBP-89 potentiates butyrate induction of endogenous p21(waf1) gene expression. Butyrates 89-97 zinc finger protein 148 Homo sapiens 70-76 10899165-7 2000 Further, cotransfection of a ZBP-89 expression vector with a 2.3-kilobase p21(waf1) reporter recapitulated the potentiation by butyrate. Butyrates 127-135 zinc finger protein 148 Homo sapiens 29-35 32060966-2 2020 Here we show that succinate accumulation induced by SDHB loss-of-function increased expression of Zinc finger protein 148 (ZNF148, also named ZBP-89) in GIST cells. Succinates 18-27 zinc finger protein 148 Homo sapiens 98-121 32060966-2 2020 Here we show that succinate accumulation induced by SDHB loss-of-function increased expression of Zinc finger protein 148 (ZNF148, also named ZBP-89) in GIST cells. Succinates 18-27 zinc finger protein 148 Homo sapiens 123-129 32060966-2 2020 Here we show that succinate accumulation induced by SDHB loss-of-function increased expression of Zinc finger protein 148 (ZNF148, also named ZBP-89) in GIST cells. Succinates 18-27 zinc finger protein 148 Homo sapiens 142-148 32060966-3 2020 Meanwhile, ZNF148 is found to be phosphorylated by ERK at Ser306, and this phosphorylation results in ZNF148 binding to Forkhead box M1 (FOXM1). seryl-seryl-seryl-arginine 58-61 zinc finger protein 148 Homo sapiens 11-17 32060966-3 2020 Meanwhile, ZNF148 is found to be phosphorylated by ERK at Ser306, and this phosphorylation results in ZNF148 binding to Forkhead box M1 (FOXM1). seryl-seryl-seryl-arginine 58-61 zinc finger protein 148 Homo sapiens 102-108