PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 30604175-3 2019 To reveal how AtBI-1 regulates sphingolipid synthesis, we screened yeast sphingolipid-deficient mutants and identified yeast ELO2 and ELO3 as novel enzymes that are essential for AtBI-1 function. Sphingolipids 31-43 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 125-129 32033944-6 2020 Elo2, a sphingolipid acyl chain elongase, was related to osmotic tolerance, through transcriptome analysis of the wild-type strain and an osmotic tolerant strain generated from ALE. Sphingolipids 8-25 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 0-4 32033944-7 2020 Overexpression of ELO2 increased the content of complex sphingolipid with longer acyl chain, thus membrane integrity and osmotic tolerance improved. Sphingolipids 56-68 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 18-22 32033944-7 2020 Overexpression of ELO2 increased the content of complex sphingolipid with longer acyl chain, thus membrane integrity and osmotic tolerance improved. Acyl Coenzyme A 81-85 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 18-22 15638242-6 2004 Surprisingly, a deletion of ELO2, also required for the synthesis of sphingolipid-containing long-chain FA, did not suppress the erg2delta upc2delta ecm22delta triple mutant. Sphingolipids 69-81 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 28-32 20727985-8 2010 Activity and expression level of fatty acid elongases, Elo1p and Elo2p were enhanced as a consequence of reduced TAG lipolysis. Fatty Acids 33-43 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 65-70 17122407-7 2007 Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis showed that GhCER6 was enzymatically active since the yeast elo2 and elo3 double-deletion mutant expressing the cotton gene produced very-long-chain fatty acids that are essential for cell growth. -chain fatty acids 228-246 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 146-150 16449229-6 2006 Elo2p and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both Elo2p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular functions. long-chain fatty acids 55-77 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 0-5 16449229-6 2006 Elo2p and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both Elo2p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular functions. long-chain fatty acids 158-180 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 0-5 16449229-6 2006 Elo2p and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both Elo2p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular functions. long-chain fatty acids 158-180 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 104-109 29458843-1 2018 Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae. long-chain fatty acids 86-108 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 10-14 29458843-1 2018 Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae. long-chain fatty acids 86-108 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 15-19 29458843-1 2018 Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae. long-chain fatty acids 125-147 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 10-14 29458843-1 2018 Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae. long-chain fatty acids 125-147 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 15-19 29458843-4 2018 The spot test showed that yeast strains with the deletion of ELO2 or ELO3 were strikingly sensitive to oleic acid, while there was no change on the growth of strain with deleted ELO1 which was involved in the elongation of C14 fatty acid (FA) to C16 FA. Oleic Acid 103-113 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 61-65 29458843-5 2018 By using GC-MS, the unsaturation index was increased in elo2 and elo3 mutants after treatment with oleic acid (OLA). Oleic Acid 101-111 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 56-60 29458843-5 2018 By using GC-MS, the unsaturation index was increased in elo2 and elo3 mutants after treatment with oleic acid (OLA). Oleic Acid 113-116 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 56-60 29458843-7 2018 The growth inhibition of elo2 and elo3 could be partially rescued by two commonly used antioxidant agents N-acetyl cysteine (NAC) and Ascorbic acid (VC). Acetylcysteine 108-125 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 25-29 29458843-7 2018 The growth inhibition of elo2 and elo3 could be partially rescued by two commonly used antioxidant agents N-acetyl cysteine (NAC) and Ascorbic acid (VC). Acetylcysteine 127-130 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 25-29 29458843-7 2018 The growth inhibition of elo2 and elo3 could be partially rescued by two commonly used antioxidant agents N-acetyl cysteine (NAC) and Ascorbic acid (VC). Ascorbic Acid 136-149 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 25-29 29458843-7 2018 The growth inhibition of elo2 and elo3 could be partially rescued by two commonly used antioxidant agents N-acetyl cysteine (NAC) and Ascorbic acid (VC). Vinyl Chloride 151-153 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 25-29 29458843-11 2018 Taken together, although disruption of ELO2 or ELO3 did not affect the cellular lipid unsaturation, they altered the distribution and propotion of cellular VLCFAs, leading to the cell membrane impairment, which augmented the ability of OLA to permeabilize the plasma membrane. Oleic Acid 236-239 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 39-43 29458843-12 2018 The data suggest that the very long-chain fatty acids elongases ELO2 and ELO3 play important roles in lipotoxic cell death induced by OLA through maintaining a balanced FA composition in plasma membrane. long-chain fatty acids 31-53 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 64-68 29458843-12 2018 The data suggest that the very long-chain fatty acids elongases ELO2 and ELO3 play important roles in lipotoxic cell death induced by OLA through maintaining a balanced FA composition in plasma membrane. Oleic Acid 134-137 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 64-68 9988704-9 1999 Overexpression of Elo2p, a component of the fatty acid elongation system, in fat1Delta cells causes C20-C26 levels to rise to approximately 20% of the total fatty acids. Fatty Acids 44-54 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 18-23 10970790-1 2000 The Saccharomyces cerevisiae protein ELO2p is involved in the elongation of saturated and monounsaturated fatty acids. saturated and monounsaturated fatty acids 76-117 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 37-42 10970790-5 2000 The predicted amino acid sequence of the open reading frame had only 29% identity with the yeast ELO2 sequence, contained a single histidine-rich domain and had six transmembrane-spanning regions, as suggested by hydropathy analysis. Histidine 131-140 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 97-101 10770748-6 2000 Strains with deletions of SYR3/ELO2 and ELO3 were resistant to syringomycin E, and lipid analyses of both mutants revealed shortened fatty acid chains and lower levels of sphingolipids. Fatty Acids 133-143 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 31-35 10770748-6 2000 Strains with deletions of SYR3/ELO2 and ELO3 were resistant to syringomycin E, and lipid analyses of both mutants revealed shortened fatty acid chains and lower levels of sphingolipids. Sphingolipids 171-184 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 31-35 9988704-9 1999 Overexpression of Elo2p, a component of the fatty acid elongation system, in fat1Delta cells causes C20-C26 levels to rise to approximately 20% of the total fatty acids. Fatty Acids 157-168 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 18-23 7768822-0 1995 Cloning and characterization of GNS1: a Saccharomyces cerevisiae gene involved in synthesis of 1,3-beta-glucan in vitro. beta-1,3-glucan 95-110 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 32-36 7768822-1 1995 The GNS1 gene product is required for the synthesis of 1,3-beta-glucan in vitro, since mutations in this gene result in exhibit an 80 to 90% reduction in 1,3-beta-glucan synthase specific activity. beta-1,3-glucan 55-70 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 4-8 7768822-2 1995 gns1 mutant strains display a pleiotropic phenotype including resistance to a pneumocandin B0 analog (L-733,560), slow growth, and mating and sporulation defects. pneumocandin B(0) 78-93 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 0-4 7768822-4 1995 The wild-type GNS1 gene was isolated by complementing the pneumocandin resistance phenotype of the gns1-1 mutation and by hybridization with a chromosome III-derived sequence being used as a probe. Echinocandins 58-70 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 14-18 9832547-6 1998 Interestingly, VBM1 and VBM2 are allelic to ELO3 and ELO2, two genes that have been shown recently to mediate the elongation of very long chain fatty acids and subsequent ceramide and inositol sphingolipid synthesis. chain fatty acids 138-155 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 24-28 9832547-6 1998 Interestingly, VBM1 and VBM2 are allelic to ELO3 and ELO2, two genes that have been shown recently to mediate the elongation of very long chain fatty acids and subsequent ceramide and inositol sphingolipid synthesis. chain fatty acids 138-155 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 53-57 9832547-6 1998 Interestingly, VBM1 and VBM2 are allelic to ELO3 and ELO2, two genes that have been shown recently to mediate the elongation of very long chain fatty acids and subsequent ceramide and inositol sphingolipid synthesis. Ceramides 171-179 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 24-28 9832547-6 1998 Interestingly, VBM1 and VBM2 are allelic to ELO3 and ELO2, two genes that have been shown recently to mediate the elongation of very long chain fatty acids and subsequent ceramide and inositol sphingolipid synthesis. Ceramides 171-179 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 53-57 9832547-6 1998 Interestingly, VBM1 and VBM2 are allelic to ELO3 and ELO2, two genes that have been shown recently to mediate the elongation of very long chain fatty acids and subsequent ceramide and inositol sphingolipid synthesis. inositol sphingolipid 184-205 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 24-28 9832547-6 1998 Interestingly, VBM1 and VBM2 are allelic to ELO3 and ELO2, two genes that have been shown recently to mediate the elongation of very long chain fatty acids and subsequent ceramide and inositol sphingolipid synthesis. inositol sphingolipid 184-205 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 53-57 9211877-0 1997 ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. Fatty Acids 81-91 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 0-4 9211877-0 1997 ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. Sphingolipids 124-136 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 0-4 9211877-1 1997 ELO2 and ELO3 were identified from the Saccharomyces cerevisiae genome data base as homologues of ELO1, a gene involved in the elongation of the fatty acid 14:0 to 16:0. Fatty Acids 145-155 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 0-4 9211877-4 1997 Gas chromatography and gas chromatography/mass spectroscopy analyses reveal that null mutations of ELO2 and ELO3 produce defects in the formation of very long chain fatty acids. chain fatty acids 159-176 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 99-103 9211877-6 1997 Elo2p appears to be involved in the elongation of fatty acids up to 24 carbons. Fatty Acids 50-61 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 0-5 9211877-6 1997 Elo2p appears to be involved in the elongation of fatty acids up to 24 carbons. Carbon 71-78 fatty acid elongase ELO2 Saccharomyces cerevisiae S288C 0-5