PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34383980-3	2021	Here, we demonstrate that Nor1 is a non-conventional target of SUMO2/3 conjugation at Lys-137 contained in an atypic psiKxSP motif referred to as the pSuM.	Lysine	86-89	small ubiquitin-like modifier 2	Mus musculus	63-70
34588985-12	2021	ER, ERK and SUMO2 inhibitors attenuated the cardioprotective effects of puerarin.	puerarin	72-80	small ubiquitin-like modifier 2	Mus musculus	12-17
30559154-8	2019	In a SCA7 knock-in mouse model, we similarly observed colocalization of SUMO2/3 with polyQ-ATXN7 inclusions in the cerebellum and retina.	polyglutamine	85-90	small ubiquitin-like modifier 2	Mus musculus	72-79
32237051-3	2020	The SUMO2/3 protease SENP3 is redox-sensitive, and SENP3 accumulation in lipopolysaccharide (LPS)-activated macrophages is ROS-dependent.	Reactive Oxygen Species	123-126	small ubiquitin-like modifier 2	Mus musculus	4-11
32232156-5	2020	The stability and catalytic function of DUSP6 are maintained through conjugation of small ubiquitin-like modifier-1 (SUMO1) and SUMO2/3 at lysine-234 (K234), which is disrupted during oxidation through transcriptional up-regulation of SUMO-deconjugating enzyme, SENP1, causing DUSP6 degradation by ubiquitin-proteasome.	Lysine	139-145	small ubiquitin-like modifier 2	Mus musculus	128-135
31749687-6	2019	We found that SUMO1, SUMO2/3, and Ubc9 are primarily nuclear proteins, which also colocalize partially with pre- and post-synaptic markers such as synaptophysin and PSD95.	Synaptophysin	147-160	small ubiquitin-like modifier 2	Mus musculus	21-26
23094087-3	2012	We have also shown that overexpression of Ubc9, SUMO-1, or SUMO-2/3 provides protection against ischemic damage in cell lines and cortical neurons exposed to oxygen/glucose deprivation, and in mice exposed to middle cerebral artery occlusion.	Oxygen	158-164	small ubiquitin-like modifier 2	Mus musculus	59-65
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	small ubiquitin-like modifier 2	Mus musculus	56-64
27412403-5	2016	Upon BA signalling, RanBP2 co-localizes with SHP at the nuclear envelope region and mediates SUMO2 modification at K68, which facilitates nuclear transport of SHP and its interaction with repressive histone modifiers to inhibit BA synthetic genes.	Bile Acids and Salts	5-7	small ubiquitin-like modifier 2	Mus musculus	93-98
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	small ubiquitin-like modifier 2	Mus musculus	21-54
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	Tretinoin	19-23	small ubiquitin-like modifier 2	Mus musculus	110-116
21291420-7	2011	In the present study, we checked SUMO2 and SUMO3 mRNA levels in cells exposed to various doses of H2O2 and in cells bearing different levels of ROS (reactive oxygen species).	Hydrogen Peroxide	98-102	small ubiquitin-like modifier 2	Mus musculus	33-38
21291420-10	2011	This revealed for the first time that the expression of SUMO2 and SUMO3 is regulated differently by ROS.	Reactive Oxygen Species	100-103	small ubiquitin-like modifier 2	Mus musculus	56-61
20941751-3	2010	In bead halo assays, the interaction between centrin-1 and SUMO-2/3 was reduced in the presence of EGTA and facilitated by the addition of CaCl2.	Egtazic Acid	99-103	small ubiquitin-like modifier 2	Mus musculus	59-65
20941751-3	2010	In bead halo assays, the interaction between centrin-1 and SUMO-2/3 was reduced in the presence of EGTA and facilitated by the addition of CaCl2.	Calcium Chloride	139-144	small ubiquitin-like modifier 2	Mus musculus	59-65
20941751-5	2010	Identification of centrin-1 as the EGTA-sensitive SUMO-2/3-interacting protein indicates the possible role of calcium in modulating the centrin-1-SUMO-2/3 interaction and suggests the importance of this interaction in mouse testis.	Egtazic Acid	35-39	small ubiquitin-like modifier 2	Mus musculus	50-56
20941751-5	2010	Identification of centrin-1 as the EGTA-sensitive SUMO-2/3-interacting protein indicates the possible role of calcium in modulating the centrin-1-SUMO-2/3 interaction and suggests the importance of this interaction in mouse testis.	Egtazic Acid	35-39	small ubiquitin-like modifier 2	Mus musculus	146-152
20941751-5	2010	Identification of centrin-1 as the EGTA-sensitive SUMO-2/3-interacting protein indicates the possible role of calcium in modulating the centrin-1-SUMO-2/3 interaction and suggests the importance of this interaction in mouse testis.	Calcium	110-117	small ubiquitin-like modifier 2	Mus musculus	50-56
20941751-5	2010	Identification of centrin-1 as the EGTA-sensitive SUMO-2/3-interacting protein indicates the possible role of calcium in modulating the centrin-1-SUMO-2/3 interaction and suggests the importance of this interaction in mouse testis.	Calcium	110-117	small ubiquitin-like modifier 2	Mus musculus	146-152
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	Tretinoin	19-23	small ubiquitin-like modifier 2	Mus musculus	208-214
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	Lysine	25-31	small ubiquitin-like modifier 2	Mus musculus	110-116
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	Lysine	25-31	small ubiquitin-like modifier 2	Mus musculus	208-214
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	didanosine	37-41	small ubiquitin-like modifier 2	Mus musculus	110-116
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	trans-1,4-dibromo-2-butene	47-51	small ubiquitin-like modifier 2	Mus musculus	110-116
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	K399	150-154	small ubiquitin-like modifier 2	Mus musculus	110-116
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	K399	150-154	small ubiquitin-like modifier 2	Mus musculus	208-214
18729496-9	2008	We showed that both free small ubiquitin-related modifier SUMO-2/3 and SUMO-1 levels are subject to tight control by the androgen 5alpha-dihydrotestosterone (DHT).	Dihydrotestosterone	130-156	small ubiquitin-like modifier 2	Mus musculus	58-66
18729496-9	2008	We showed that both free small ubiquitin-related modifier SUMO-2/3 and SUMO-1 levels are subject to tight control by the androgen 5alpha-dihydrotestosterone (DHT).	Dihydrotestosterone	158-161	small ubiquitin-like modifier 2	Mus musculus	58-66
18602382-3	2008	Immunofluorescence microscopy revealed that SUMO1, SUMO2/3 and UBE2I (also known as UBC9) were localized to the XY body in pachytene and diplotene spermatocytes, while only SUMO2/3 and UBE2I were detected near centromeres in metaphase I spermatocytes.	pachytene	123-132	small ubiquitin-like modifier 2	Mus musculus	51-56