PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
15033991-6	2004	In several notable cases (e.g. claudin-1 and meprin-1beta) the pattern of gene expression identified in adriamycin nephropathy in vivo was replicated during transdifferentiation of renal tubule epithelial cells to a fibroblast-like phenotype in vitro on exposure to transforming growth factor-beta and epidermal growth factor suggesting a role in fibrogenesis.	Doxorubicin	104-114	meprin 1 beta	Mus musculus	45-57
25957482-0	2015	Basement membrane protein nidogen-1 is a target of meprin beta in cisplatin nephrotoxicity.	Cisplatin	66-75	meprin 1 beta	Mus musculus	51-62
1929422-1	1991	Meprin A and B are disulfide-linked, tetrameric metalloendopeptidases in renal brush border membranes.	Disulfides	19-28	meprin 1 beta	Mus musculus	0-14
34508852-6	2021	To avoid influence by other fra-2 regulated genes, we additionally generated a mouse model that enabled tamoxifen-inducible expression of meprin beta under the Krt5-promotor to mimic the pathological condition.	Tamoxifen	104-113	meprin 1 beta	Mus musculus	138-149
31411076-0	2019	LC-MS-based metabolomics analysis to identify meprin beta-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury.	Streptozocin	109-112	meprin 1 beta	Mus musculus	46-57
31411076-7	2019	In the current study, global metabolomics analysis identified differentiating metabolites in kidney tissues from wild-type (WT) and meprin beta knockout (betaKO) mice with STZ-induced type 1 diabetes.	Streptozocin	172-175	meprin 1 beta	Mus musculus	132-143
31411076-13	2019	The data suggest that meprin beta activity enhances diabetic kidney injury in part by altering the metabolite balance in kidneys, favoring high levels of uremic toxins such as indoxyl sulfate and N-Methyl-pyridone-carboxamide.	Indican	176-191	meprin 1 beta	Mus musculus	22-33
31411076-13	2019	The data suggest that meprin beta activity enhances diabetic kidney injury in part by altering the metabolite balance in kidneys, favoring high levels of uremic toxins such as indoxyl sulfate and N-Methyl-pyridone-carboxamide.	n-methyl-pyridone-carboxamide	196-225	meprin 1 beta	Mus musculus	22-33
28003343-4	2017	This finding fits perfectly to the unique cleavage specificity of meprin beta with a strong preference for aspartate residues and suggests coevolution of protease and substrate.	Aspartic Acid	107-116	meprin 1 beta	Mus musculus	66-77
34435182-4	2021	The other subclass of ALPs in vertebrates - the meprins, comprised of meprin alpha and meprin beta - are emerging as regulators of tissue and ECM homeostasis but have so far been only limitedly investigated.	Tiopronin	48-55	meprin 1 beta	Mus musculus	87-98
35235058-3	2022	A potential candidate for alternative Abeta peptides generation is the metalloproteinase meprin beta, which cleaves APP predominantly at alanine in p2 and in this study we can detect an increased meprin beta expression in AD brain.	Alanine	137-144	meprin 1 beta	Mus musculus	89-100
35235058-3	2022	A potential candidate for alternative Abeta peptides generation is the metalloproteinase meprin beta, which cleaves APP predominantly at alanine in p2 and in this study we can detect an increased meprin beta expression in AD brain.	P-2	148-150	meprin 1 beta	Mus musculus	89-100
31023251-9	2019	METHODS: Low dose STZ was used to induce type 1 diabetes in 8-week old wild-type (WT) and meprin beta knockout (betaKO) mice.	Streptozocin	18-21	meprin 1 beta	Mus musculus	90-101
31023251-15	2019	Annotated meprin beta expression-associated metabolites with strong variable importance in projection (VIP) scores play roles in lipid metabolism (LysoPC(16:1(9Z)), taurocholic acid), amino acid metabolism (indoxyl sulfate, hippuric acid), and neurotransmitter/stress hormone synthesis (cortisol, 3-methoxy-4-hydroxyphenylethylene glycolsulfate, homovanillic acid sulfate).	Taurocholic Acid	165-181	meprin 1 beta	Mus musculus	10-21
31023251-15	2019	Annotated meprin beta expression-associated metabolites with strong variable importance in projection (VIP) scores play roles in lipid metabolism (LysoPC(16:1(9Z)), taurocholic acid), amino acid metabolism (indoxyl sulfate, hippuric acid), and neurotransmitter/stress hormone synthesis (cortisol, 3-methoxy-4-hydroxyphenylethylene glycolsulfate, homovanillic acid sulfate).	Indican	207-222	meprin 1 beta	Mus musculus	10-21
31023251-15	2019	Annotated meprin beta expression-associated metabolites with strong variable importance in projection (VIP) scores play roles in lipid metabolism (LysoPC(16:1(9Z)), taurocholic acid), amino acid metabolism (indoxyl sulfate, hippuric acid), and neurotransmitter/stress hormone synthesis (cortisol, 3-methoxy-4-hydroxyphenylethylene glycolsulfate, homovanillic acid sulfate).	hippuric acid	224-237	meprin 1 beta	Mus musculus	10-21
31023251-15	2019	Annotated meprin beta expression-associated metabolites with strong variable importance in projection (VIP) scores play roles in lipid metabolism (LysoPC(16:1(9Z)), taurocholic acid), amino acid metabolism (indoxyl sulfate, hippuric acid), and neurotransmitter/stress hormone synthesis (cortisol, 3-methoxy-4-hydroxyphenylethylene glycolsulfate, homovanillic acid sulfate).	Hydrocortisone	287-295	meprin 1 beta	Mus musculus	10-21
31023251-15	2019	Annotated meprin beta expression-associated metabolites with strong variable importance in projection (VIP) scores play roles in lipid metabolism (LysoPC(16:1(9Z)), taurocholic acid), amino acid metabolism (indoxyl sulfate, hippuric acid), and neurotransmitter/stress hormone synthesis (cortisol, 3-methoxy-4-hydroxyphenylethylene glycolsulfate, homovanillic acid sulfate).	3-methoxy-4-hydroxyphenylglycol sulfate	297-344	meprin 1 beta	Mus musculus	10-21
31023251-15	2019	Annotated meprin beta expression-associated metabolites with strong variable importance in projection (VIP) scores play roles in lipid metabolism (LysoPC(16:1(9Z)), taurocholic acid), amino acid metabolism (indoxyl sulfate, hippuric acid), and neurotransmitter/stress hormone synthesis (cortisol, 3-methoxy-4-hydroxyphenylethylene glycolsulfate, homovanillic acid sulfate).	Homovanillic acid sulfate	346-371	meprin 1 beta	Mus musculus	10-21
27478637-8	2016	Transfection of kidney cells (MDCK and HEK293) with meprin beta cDNA prevented accumulation of OS-9 following exposure to the hypoxia mimic, CoCl2.	cobaltous chloride	141-146	meprin 1 beta	Mus musculus	52-63
25957482-7	2015	In addition, meprin beta-deficient mice, but not meprin alpha-deficient mice, subjected to cisplatin nephrotoxicity significantly suppressed excretion of cleaved nidogen-1, further suggesting that meprin beta is involved in the cleavage of nidogen-1.	Cisplatin	91-100	meprin 1 beta	Mus musculus	13-24
25957482-7	2015	In addition, meprin beta-deficient mice, but not meprin alpha-deficient mice, subjected to cisplatin nephrotoxicity significantly suppressed excretion of cleaved nidogen-1, further suggesting that meprin beta is involved in the cleavage of nidogen-1.	Cisplatin	91-100	meprin 1 beta	Mus musculus	197-208
25957482-8	2015	These studies provide strong evidence for a pathophysiological link between meprin beta and urinary excretion of cleaved nidogen-1 during cisplatin-induced AKI.	Cisplatin	138-147	meprin 1 beta	Mus musculus	76-87
18786924-4	2008	The results demonstrate that the meprin beta subunit of meprins A and B cleaves proIL-18 into a smaller 17-kDa product.	proil-18	80-88	meprin 1 beta	Mus musculus	33-44
18786924-6	2008	The cleavage occurred in vitro with a Km of 1.3 microm and in Madin-Darby canine kidney cells transfected with meprin beta when proIL-18 was added to the culture medium.	proil-18	128-136	meprin 1 beta	Mus musculus	111-122
18786924-11	2008	This study identifies proIL-18 as a biologically important substrate for meprin beta and implicates meprins in the modulation of inflammation.	proil	22-27	meprin 1 beta	Mus musculus	73-84
22940918-4	2013	Of the 151 new extracellular substrates we identified, it was notable that ADAM10 (a disintegrin and metalloprotease domain-containing protein 10)-the constitutive alpha-secretase-is activated by meprin beta through cleavage of the propeptide.	propeptide	232-242	meprin 1 beta	Mus musculus	196-207
21795642-7	2011	The meprin B cleavage site in villin was Glu(744)-Val(745).	Glutamic Acid	41-44	meprin 1 beta	Mus musculus	4-12
21795642-7	2011	The meprin B cleavage site in villin was Glu(744)-Val(745).	Valine	50-53	meprin 1 beta	Mus musculus	4-12
21646356-5	2011	Based on a novel proteomics technique termed terminal amine isotopic labeling of substrates (TAILS), APP was identified as a substrate for meprin beta.	Amines	54-59	meprin 1 beta	Mus musculus	139-150