PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34060199-6	2021	Moreover, expression of oxidative stress, inflammatory cytokines and/or autophagy-related protein was tested when IP3 R was silenced or overexpressed in ESS-treated and/or 3-MA-treated cells.	ESS	153-156	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	114-119
2548727-6	1989	The IP3 receptor protein is selectively phosphorylated by cyclic AMP (cAMP) dependent protein kinase.	Cyclic AMP	58-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-16
2548727-6	1989	The IP3 receptor protein is selectively phosphorylated by cyclic AMP (cAMP) dependent protein kinase.	Cyclic AMP	70-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-16
34060199-9	2021	In addition, IP3 R was significantly decreased in patients with COPD and ESS-treated cells.	ESS	73-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	13-18
34060199-10	2021	Loss of IP3 R statistically increased expression of oxidative stress and inflammatory cytokines in ESS-treated HBE cells, and overexpression of IP3 R reversed the above functions.	ESS	99-102	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	8-13
34060199-12	2021	Additionally, we detected that administration of 3-MA significantly reversed the protective effects of IP3 R overexpression on ESS-induced oxidative stress and inflammatory injury.	3-methyladenine	49-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	103-108
34060199-12	2021	Additionally, we detected that administration of 3-MA significantly reversed the protective effects of IP3 R overexpression on ESS-induced oxidative stress and inflammatory injury.	ESS	127-130	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	103-108
34060199-13	2021	Our results suggest that IP3 R might exert a protective role against ESS-induced oxidative stress and inflammation damage in HBE cells.	ESS	69-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	25-30
33887224-10	2021	Simulations suggest the experimentally observed optimal timing window of CF stimuli to arise from the relative timing of CF influx of Ca2+ and IP3 production sensitizing IP3R for Ca2+ induced Ca2+ release.	Inositol 1,4,5-Trisphosphate	143-146	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	170-174
33661276-4	2021	Mechanistically, GRM8 activation counteracted neuronal cAMP accumulation, thereby directly desensitizing the inositol 1,4,5-trisphosphate receptor (IP3R).	Cyclic AMP	55-59	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	148-152
33751770-0	2021	Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival.	desmethylxestospongin b	54-77	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	26-30
33751715-9	2021	The inositol 1,4,5-triphosphate receptor (IP3R)-glucose-regulated protein 75 (Grp75)-voltage-dependent anion channel (VDAC) complex, which was enriched in MAMs, was also increased.	Glucose	48-55	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-46
33751715-10	2021	The accumulation of mitochondrial calcium could be blocked by inhibiting with the IP3R inhibitor Xestospongin C (XeC) in Hcy-treated cells.	Calcium	34-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-86
33751715-10	2021	The accumulation of mitochondrial calcium could be blocked by inhibiting with the IP3R inhibitor Xestospongin C (XeC) in Hcy-treated cells.	xestospongin C	97-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-86
33751715-10	2021	The accumulation of mitochondrial calcium could be blocked by inhibiting with the IP3R inhibitor Xestospongin C (XeC) in Hcy-treated cells.	xestospongin C	113-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-86
33751715-10	2021	The accumulation of mitochondrial calcium could be blocked by inhibiting with the IP3R inhibitor Xestospongin C (XeC) in Hcy-treated cells.	Homocysteine	121-124	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-86
33751715-12	2021	In conclusion, Hcy-induced mitochondrial dysfunction and dynamics disorder in endothelial cells were mainly related to the increase of calcium as a result of the upregulated expressions of the MCU and the IP3R-Grp75-VDAC complex in MAMs.	Homocysteine	15-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	205-209
33751715-12	2021	In conclusion, Hcy-induced mitochondrial dysfunction and dynamics disorder in endothelial cells were mainly related to the increase of calcium as a result of the upregulated expressions of the MCU and the IP3R-Grp75-VDAC complex in MAMs.	Calcium	135-142	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	205-209
33929090-5	2021	SFN reversed the increase of Ca2+ induced by fatty acid and inhibited the Ca2+ channel IP3R.	sulforaphane	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	87-91
33864571-0	2021	Upregulated SOCC and IP3R calcium channels and subsequent elevated cytoplasmic calcium signaling promote nonalcoholic fatty liver disease by inhibiting autophagy.	Calcium	26-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	21-25
33864571-1	2021	Nonalcoholic fatty liver disease (NAFLD) is related to elevated cytoplasmic calcium signaling in hepatocytes, which may be mediated by store-operated calcium channel (SOCC) and inositol triphosphate receptor (IP3R).	Calcium	76-83	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	209-213
33864571-9	2021	In the OOA model, upregulated extracellular regulated protein kinases 1/2 (ERK1/2), which can be regulated by SOCC and IP3R proteins transient receptor potential canonical 1 (TRPC1)/IP3R with elevated cytoplasmic calcium signaling, over-inhibited forkhead/winged helix O (FOXO) signaling and over-activated mammalian target of rapamycin complex 1 (mTORC1) signaling.	Calcium	213-220	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	119-123
33864571-9	2021	In the OOA model, upregulated extracellular regulated protein kinases 1/2 (ERK1/2), which can be regulated by SOCC and IP3R proteins transient receptor potential canonical 1 (TRPC1)/IP3R with elevated cytoplasmic calcium signaling, over-inhibited forkhead/winged helix O (FOXO) signaling and over-activated mammalian target of rapamycin complex 1 (mTORC1) signaling.	Calcium	213-220	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	182-186
33864571-9	2021	In the OOA model, upregulated extracellular regulated protein kinases 1/2 (ERK1/2), which can be regulated by SOCC and IP3R proteins transient receptor potential canonical 1 (TRPC1)/IP3R with elevated cytoplasmic calcium signaling, over-inhibited forkhead/winged helix O (FOXO) signaling and over-activated mammalian target of rapamycin complex 1 (mTORC1) signaling.	Sirolimus	327-336	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	119-123
33864571-9	2021	In the OOA model, upregulated extracellular regulated protein kinases 1/2 (ERK1/2), which can be regulated by SOCC and IP3R proteins transient receptor potential canonical 1 (TRPC1)/IP3R with elevated cytoplasmic calcium signaling, over-inhibited forkhead/winged helix O (FOXO) signaling and over-activated mammalian target of rapamycin complex 1 (mTORC1) signaling.	Sirolimus	327-336	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	182-186
33864571-12	2021	Our findings indicate that upregulated SOCC and IP3R channels and subsequent elevated cytoplasmic calcium signaling in hepatocyte fatty lesions inhibits hepatocyte autophagy through (TRPC1/IP3R)/ERK/(FOXO/mTORC1) signaling pathways, causes lipid accumulation and degeneration in hepatocytes, and promotes NAFLD occurrence and development.	Calcium	98-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	189-193
33832505-12	2021	Targeting Sig-1R, which interacts with IP3R, with the antagonist BD1047 also abrogated EGF-induced calcium release.	N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin	65-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	39-43
33792909-8	2021	PLC releases Inositol-1,4,5-trisphosphate (IP3) causing IP3-receptor (IP3R) activation and Ca2+ flux from the endoplasmic reticulum into the cytosol, which stimulates Ca2+ -release-activated-channels (CRAC)-mediated Ca2+ influx.	-1,4,5-trisphosphate	21-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-68
33421534-7	2021	The trypanosome IP3R is stimulated by luminal phosphate and pyrophosphate, which are hydrolysis products of polyphosphate (polyP), and inhibited by tripolyphosphate (polyP3), which is the most abundant polyP in acidocalcisomes.	Phenobarbital	38-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	16-20
33421534-7	2021	The trypanosome IP3R is stimulated by luminal phosphate and pyrophosphate, which are hydrolysis products of polyphosphate (polyP), and inhibited by tripolyphosphate (polyP3), which is the most abundant polyP in acidocalcisomes.	Phosphates	46-55	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	16-20
33421534-7	2021	The trypanosome IP3R is stimulated by luminal phosphate and pyrophosphate, which are hydrolysis products of polyphosphate (polyP), and inhibited by tripolyphosphate (polyP3), which is the most abundant polyP in acidocalcisomes.	diphosphoric acid	60-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	16-20
33421534-7	2021	The trypanosome IP3R is stimulated by luminal phosphate and pyrophosphate, which are hydrolysis products of polyphosphate (polyP), and inhibited by tripolyphosphate (polyP3), which is the most abundant polyP in acidocalcisomes.	Polyphosphates	108-121	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	16-20
33421534-7	2021	The trypanosome IP3R is stimulated by luminal phosphate and pyrophosphate, which are hydrolysis products of polyphosphate (polyP), and inhibited by tripolyphosphate (polyP3), which is the most abundant polyP in acidocalcisomes.	Polyphosphates	123-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	16-20
33421534-7	2021	The trypanosome IP3R is stimulated by luminal phosphate and pyrophosphate, which are hydrolysis products of polyphosphate (polyP), and inhibited by tripolyphosphate (polyP3), which is the most abundant polyP in acidocalcisomes.	triphosphoric acid	148-164	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	16-20
33421534-7	2021	The trypanosome IP3R is stimulated by luminal phosphate and pyrophosphate, which are hydrolysis products of polyphosphate (polyP), and inhibited by tripolyphosphate (polyP3), which is the most abundant polyP in acidocalcisomes.	polyp3	166-172	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	16-20
33421534-7	2021	The trypanosome IP3R is stimulated by luminal phosphate and pyrophosphate, which are hydrolysis products of polyphosphate (polyP), and inhibited by tripolyphosphate (polyP3), which is the most abundant polyP in acidocalcisomes.	Polyphosphates	166-171	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	16-20
33515654-5	2021	While, the orexin-A-induced potentiation was blocked when Ca2+ was chelated by internal infusion of BAPTA, and the orexin-A effect was abolished by the IP3 receptor antagonists heparin and Xe-C.	Heparin	177-184	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	152-164
33792909-8	2021	PLC releases Inositol-1,4,5-trisphosphate (IP3) causing IP3-receptor (IP3R) activation and Ca2+ flux from the endoplasmic reticulum into the cytosol, which stimulates Ca2+ -release-activated-channels (CRAC)-mediated Ca2+ influx.	-1,4,5-trisphosphate	21-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-74
33792909-8	2021	PLC releases Inositol-1,4,5-trisphosphate (IP3) causing IP3-receptor (IP3R) activation and Ca2+ flux from the endoplasmic reticulum into the cytosol, which stimulates Ca2+ -release-activated-channels (CRAC)-mediated Ca2+ influx.	Inositol 1,4,5-Trisphosphate	43-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-68
33792909-8	2021	PLC releases Inositol-1,4,5-trisphosphate (IP3) causing IP3-receptor (IP3R) activation and Ca2+ flux from the endoplasmic reticulum into the cytosol, which stimulates Ca2+ -release-activated-channels (CRAC)-mediated Ca2+ influx.	Inositol 1,4,5-Trisphosphate	43-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-74
33738285-2	2021	The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role.	Calcium	164-171	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	134-147
33427940-8	2021	Release of TRPC1 and IP3R from Cav1 would activate downstream signaling cascades, including store-operated calcium entry, which could explain the influx in calcium after nsPEF exposure.	Calcium	107-114	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	21-25
33427940-8	2021	Release of TRPC1 and IP3R from Cav1 would activate downstream signaling cascades, including store-operated calcium entry, which could explain the influx in calcium after nsPEF exposure.	Calcium	156-163	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	21-25
33797036-5	2021	We observe that pridopidine prevents the disruption of mitochondria-ER contact sites and improves the co-localization of inositol 1,4,5-trisphosphate receptor (IP3R) and its chaperone S1R with mitochondria in YAC128 neurons, leading to increased mitochondrial activity, elongation, and motility.	pridopidine	16-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	160-164
33738285-2	2021	The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role.	Calcium	164-171	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	149-153
33398498-4	2021	We discuss the contribution of the inositol 1,4,5-trisphosphate (IP3) receptor Ca2+ release channel as an auxiliary pathway to Ca2+ signaling, and we review IP3 receptor-induced Ca2+ release involvement in beat-to-beat ECC, nuclear Ca2+ signaling, and arrhythmogenesis.	Inositol 1,4,5-Trisphosphate	65-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	157-169
33404366-10	2021	Effects of O2 on [Ca2+]i are rescued by driving expression of clock proteins, via effects on the Ca2+ channels IP3R and Orai1.	Oxygen	11-13	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-115
33450506-3	2021	IP3R channels are targeted by the BH4 domain of Bcl-2.	sapropterin	34-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
33127334-8	2021	Bruton"s tyrosine kinase (Btk)/Phospholipase C(PLC) gamma/inositol 1,4,5-triphosphate receptor (IP3R) played a major role in regulating calcium overload in LPS-induced HUVEC.	Calcium	136-143	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-100
33573671-2	2021	ITPR3, as a ubiquitous endoplasmic reticulum calcium channel protein, was reported to be involved in the development and progression of various types of cancer.	Calcium	45-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-5
33214166-4	2021	Loss of type 3 inositol 1,4,5-trisphosphate receptor (ITPR3), an apical intracellular calcium channel necessary for cholangiocyte secretion, was used to reflect cholestatic changes.	Calcium	86-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	54-59
33441856-0	2021	D,L-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca2+ release and decrease in Ca2+ efflux, elevating [Ca2+]i.	d,l-methadone	0-13	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-84
33441856-5	2021	D,L-Methadone evokes IP3R-mediated ER Ca2+ release that is inhibited by OPRM1 loss.	d,l-methadone	0-13	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	21-25
33441856-9	2021	Altogether, our findings point to OPRM1 as a specific target of D,L-methadone in leukemic cells, and that OPRM1 activation by D,L-methadone disrupts IP3R-mediated ER Ca2+ release and rate of Ca2+ efflux, causing a rise in [Ca2+]i that upregulates the calpain-1-Bid-cytochrome C-caspase-3/12 apoptotic pathway.	d,l-methadone	126-139	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	149-153
33043479-8	2021	In additional experiments on the NFAT pathway, the very first phase (TCR signaling) remained unchanged on treatment with RNO, but RNO treatment increased IP3R expression and suppressed calcineurin activity.	roflumilast N-oxide	130-133	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	154-158
33043479-9	2021	Calcineurin activity, reduced by RNO, increased on treatment with an IP3 receptor agonist.PED4 inhibitor, roflumilast isspeculated to suppress T cell proliferation by interfering with IP3-IP3R binding to inhibit calcium emission, blocking pathway activation from this phase onward, eventually decreasing the level of a growth factor for T cell proliferation, IL-2.	Roflumilast	106-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	69-81
33043479-9	2021	Calcineurin activity, reduced by RNO, increased on treatment with an IP3 receptor agonist.PED4 inhibitor, roflumilast isspeculated to suppress T cell proliferation by interfering with IP3-IP3R binding to inhibit calcium emission, blocking pathway activation from this phase onward, eventually decreasing the level of a growth factor for T cell proliferation, IL-2.	Roflumilast	106-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	188-192
33043479-9	2021	Calcineurin activity, reduced by RNO, increased on treatment with an IP3 receptor agonist.PED4 inhibitor, roflumilast isspeculated to suppress T cell proliferation by interfering with IP3-IP3R binding to inhibit calcium emission, blocking pathway activation from this phase onward, eventually decreasing the level of a growth factor for T cell proliferation, IL-2.	Inositol 1,4,5-Trisphosphate	69-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	188-192
33043479-9	2021	Calcineurin activity, reduced by RNO, increased on treatment with an IP3 receptor agonist.PED4 inhibitor, roflumilast isspeculated to suppress T cell proliferation by interfering with IP3-IP3R binding to inhibit calcium emission, blocking pathway activation from this phase onward, eventually decreasing the level of a growth factor for T cell proliferation, IL-2.	Calcium	212-219	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	69-81
33043479-9	2021	Calcineurin activity, reduced by RNO, increased on treatment with an IP3 receptor agonist.PED4 inhibitor, roflumilast isspeculated to suppress T cell proliferation by interfering with IP3-IP3R binding to inhibit calcium emission, blocking pathway activation from this phase onward, eventually decreasing the level of a growth factor for T cell proliferation, IL-2.	Calcium	212-219	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	188-192
33408296-0	2021	Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor.	bis(4-hydroxyphenyl)sulfone	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-84
33408296-8	2021	We found that BPA bound directly to the IP3 binding core domain of the IP3 receptor, and BPA competed with IP3 on this site.	bisphenol A	14-17	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-83
33276427-4	2020	Inositol 1,4,5-trisphosphate receptor (IP3R) is a widely expressed channel for calcium stores.	Calcium	79-86	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	39-43
33408296-8	2021	We found that BPA bound directly to the IP3 binding core domain of the IP3 receptor, and BPA competed with IP3 on this site.	Inositol 1,4,5-Trisphosphate	40-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-83
33408296-8	2021	We found that BPA bound directly to the IP3 binding core domain of the IP3 receptor, and BPA competed with IP3 on this site.	bisphenol A	89-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-83
33408296-9	2021	In addition, overexpression of this domain of the IP3 receptor in Hep3B cells inhibited the stabilization of Nrf2 by BPA.	bisphenol A	117-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-62
33408296-10	2021	These results clarified that the IP3 receptor is a new target of BPA, and that BPA induces Ca2+ efflux from the endoplasmic reticulum via activation of the IP3 receptor.	bisphenol A	65-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	33-45
33408296-10	2021	These results clarified that the IP3 receptor is a new target of BPA, and that BPA induces Ca2+ efflux from the endoplasmic reticulum via activation of the IP3 receptor.	bisphenol A	65-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-168
33408296-10	2021	These results clarified that the IP3 receptor is a new target of BPA, and that BPA induces Ca2+ efflux from the endoplasmic reticulum via activation of the IP3 receptor.	bisphenol A	79-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-168
33113502-10	2021	In addition, ALA (0, 50, 100, and 200 muM) reduced Compound 48/80 (C48/80) (30 mug/ml)-or Substance P (SP) (4 mug/ml)-induced calcium influx, mast cell degranulation and cytokines and chemokine release in Laboratory of Allergic Disease 2 (LAD2) cells via Lyn-PLCgamma-IP3R-Ca2+ and Lyn-p38/NF-kappaB signaling pathway.	alpha-Linolenic Acid	13-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	268-272
33383780-6	2020	Further, we also investigated the role of stereo-specificity of IP3 molecule and its analogs in binding with the IP3 receptor.	Inositol 1,4,5-Trisphosphate	64-67	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	113-125
33276427-5	2020	After being activated by inositol 1,4,5-trisphosphate (IP3) and calcium signaling at a lower concentration, IP3R can regulate the release of Ca2+ from stores into cytoplasm, and eventually trigger downstream events.	Inositol 1,4,5-Trisphosphate	25-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	108-112
33276427-5	2020	After being activated by inositol 1,4,5-trisphosphate (IP3) and calcium signaling at a lower concentration, IP3R can regulate the release of Ca2+ from stores into cytoplasm, and eventually trigger downstream events.	Inositol 1,4,5-Trisphosphate	55-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	108-112
33276427-5	2020	After being activated by inositol 1,4,5-trisphosphate (IP3) and calcium signaling at a lower concentration, IP3R can regulate the release of Ca2+ from stores into cytoplasm, and eventually trigger downstream events.	Calcium	64-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	108-112
33276427-6	2020	The closure of the IP3R channel caused by a rise in intracellular calcium signals and the activation of the calcium pump jointly restores the calcium store to a normal level.	Calcium	66-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-23
33276427-6	2020	The closure of the IP3R channel caused by a rise in intracellular calcium signals and the activation of the calcium pump jointly restores the calcium store to a normal level.	Calcium	108-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-23
33276427-6	2020	The closure of the IP3R channel caused by a rise in intracellular calcium signals and the activation of the calcium pump jointly restores the calcium store to a normal level.	Calcium	108-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-23
33276427-7	2020	In this review, we aim to discuss structural features of IP3R channels and the underlying mechanism of IP3R channel-mediated calcium signaling and further focus on the research progress of IP3R expression and function in the male reproductive system.	Calcium	125-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	103-107
33276427-7	2020	In this review, we aim to discuss structural features of IP3R channels and the underlying mechanism of IP3R channel-mediated calcium signaling and further focus on the research progress of IP3R expression and function in the male reproductive system.	Calcium	125-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	103-107
32690540-5	2020	Mechanistically, BBOX1 binds with the calcium channel inositol-1,4,5-trisphosphate receptor type 3 (IP3R3) in an enzymatic-dependent manner and prevents its ubiquitination and proteasomal degradation.	Calcium	38-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-105
33002828-12	2020	Remarkably, kaempferol was found to bind with DJ-1 protein, and initially prevented DJ-1 from translocating to the plasma membrane, thereby inhibited full activation of Lyn, and eventually restrained those receptor-distal signaling molecules, involved Syk, Btk, PLCgamma, IP3R, PKC, MAPKs, Akt and NF-kappaB.	kaempferol	12-22	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	272-276
33335902-10	2020	Activation of ICl ,swell by Hypo was attenuated by blocking receptors for inositol trisphosphate and ryanodine (IP3R; RyR), as well as by inhibiting Ca2+ influx.	Ryanodine	101-110	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-116
32690540-5	2020	Mechanistically, BBOX1 binds with the calcium channel inositol-1,4,5-trisphosphate receptor type 3 (IP3R3) in an enzymatic-dependent manner and prevents its ubiquitination and proteasomal degradation.	,4,5-trisphosphate	64-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-105
32690540-6	2020	BBOX1 depletion suppresses IP3R3 mediated endoplasmic reticulum calcium release, therefore impairing calcium-dependent energy-generating processes including mitochondrial respiration and mTORC1 mediated glycolysis, which leads to apoptosis and impaired cell cycle progression in TNBC cells.	Calcium	64-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	27-32
32690540-6	2020	BBOX1 depletion suppresses IP3R3 mediated endoplasmic reticulum calcium release, therefore impairing calcium-dependent energy-generating processes including mitochondrial respiration and mTORC1 mediated glycolysis, which leads to apoptosis and impaired cell cycle progression in TNBC cells.	Calcium	101-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	27-32
32690540-8	2020	Our study highlights the importance of targeting previously uncharacterized BBOX1-IP3R3-calcium oncogenic signaling axis in TNBC.	Calcium	88-95	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-87
32871099-5	2020	A key result of our study is that IP3R activation increases Ca2+ transient duration for a broad range of IP3R properties, but the effect of IP3R activation on Ca2+ transient amplitude is dependent on IP3 concentration.	Inositol 1,4,5-Trisphosphate	34-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-109
32628939-5	2020	The model accounts for the biphasic regulation of Ca2+ on the IP3 receptor (IP3R) and the positive feedback from Ca2+ on IP3 metabolism, via activation of phospholipase C (PLC) by agonist and Ca2+.	Inositol 1,4,5-Trisphosphate	62-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-80
34056016-1	2020	Background: IP3-induced Ca2+ release, mediated by IP3R, is one of the most momentous cellular signaling mechanisms that regulate in a wide variety of essential cellular functions.	Inositol 1,4,5-Trisphosphate	12-15	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
32712383-6	2020	PLC catalyzes the hydrolysis of phosphatidyl-inositol-4,5-bisphosphate (PIP2) to diacylglycerol and inositol-trisphosphate (IP3), leading to activation of protein kinase C (PKC) and the IP3-receptor.	Phosphatidylinositol 4,5-Diphosphate	32-70	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	186-198
32712383-6	2020	PLC catalyzes the hydrolysis of phosphatidyl-inositol-4,5-bisphosphate (PIP2) to diacylglycerol and inositol-trisphosphate (IP3), leading to activation of protein kinase C (PKC) and the IP3-receptor.	Phosphatidylinositol 4,5-Diphosphate	72-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	186-198
32712383-6	2020	PLC catalyzes the hydrolysis of phosphatidyl-inositol-4,5-bisphosphate (PIP2) to diacylglycerol and inositol-trisphosphate (IP3), leading to activation of protein kinase C (PKC) and the IP3-receptor.	Diglycerides	81-95	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	186-198
32712383-6	2020	PLC catalyzes the hydrolysis of phosphatidyl-inositol-4,5-bisphosphate (PIP2) to diacylglycerol and inositol-trisphosphate (IP3), leading to activation of protein kinase C (PKC) and the IP3-receptor.	inositol-trisphosphate	100-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	186-198
32712383-6	2020	PLC catalyzes the hydrolysis of phosphatidyl-inositol-4,5-bisphosphate (PIP2) to diacylglycerol and inositol-trisphosphate (IP3), leading to activation of protein kinase C (PKC) and the IP3-receptor.	Inositol 1,4,5-Trisphosphate	124-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	186-198
32871099-5	2020	A key result of our study is that IP3R activation increases Ca2+ transient duration for a broad range of IP3R properties, but the effect of IP3R activation on Ca2+ transient amplitude is dependent on IP3 concentration.	Inositol 1,4,5-Trisphosphate	34-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-109
33241108-2	2020	Our recent study uncovered a novel signaling pathway implicating gamma-butyrobetaine hydroxylase 1 (BBOX1) in the control of cell growth in TNBC, via inositol 1, 4, 5-trisphosphate receptor type 3 (IP3R3) mediated calcium signaling which is essential for cellular energy metabolism.	Calcium	214-221	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	150-196
33241108-2	2020	Our recent study uncovered a novel signaling pathway implicating gamma-butyrobetaine hydroxylase 1 (BBOX1) in the control of cell growth in TNBC, via inositol 1, 4, 5-trisphosphate receptor type 3 (IP3R3) mediated calcium signaling which is essential for cellular energy metabolism.	Calcium	214-221	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-203
32903370-0	2020	IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency.	Calcium	41-48	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
32811377-12	2020	Within the GO:0050913 gene set, 3 genes were associated with extreme TCPA in our study (P<0.001): TAS2R20, TAS2R50, and ITPR3.	tcpa	69-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	120-125
32668368-3	2020	We highlight a recent paper that demonstrates that luminal [Ca2+] potently inhibits IP3R activity.	Phenobarbital	51-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	84-88
32101765-5	2020	The Ca2+ release was significantly attenuated by Xestospongin C, a known inhibitor of the Inositol 1,4,5-trisphosphate receptor (IP3R) channel and was unaffected by the phospholipase C (PLC) inhibitor, U73122.	xestospongin C	49-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-133
32903370-7	2020	Instead, compensatory mechanism for calcium handling in RYR2-/--iPSC-CMs is partially mediated by the inositol 1,4,5-trisphosphate receptor (IP3R).	Calcium	36-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
31183746-1	2020	The goal of this study was to investigate the immunolocalization of inositol 1,4,5-trisphosphate receptor (IP3R) and vacuolar ATPase (V-ATPase) in ameloblastomas with special attention to the invasive front.	-trisphosphate	82-96	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-111
32353764-1	2020	Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types.	Inositol 1,4,5-Trisphosphate	33-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-134
32353764-1	2020	Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types.	Inositol 1,4,5-Trisphosphate	33-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-140
32353764-1	2020	Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types.	Inositol 1,4,5-Trisphosphate	63-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-134
32353764-1	2020	Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types.	Inositol 1,4,5-Trisphosphate	63-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-140
32353764-1	2020	Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types.	Inositol 1,4,5-Trisphosphate	122-125	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-140
32119997-10	2020	Calcium chelators BAPTA-AM or APB, a specific inhibitor of IP3R, improved cell viability.	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	59-63
32421702-2	2020	EB3 contributes to pathological vascular leakage through interacting with the inositol 1,4,5-trisphosphate receptor 3 (IP3R3), a calcium channel located at the endoplasmic reticulum membrane.	Inositol 1,4,5-Trisphosphate	78-106	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	119-124
32421702-2	2020	EB3 contributes to pathological vascular leakage through interacting with the inositol 1,4,5-trisphosphate receptor 3 (IP3R3), a calcium channel located at the endoplasmic reticulum membrane.	Calcium	129-136	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	119-124
32101765-5	2020	The Ca2+ release was significantly attenuated by Xestospongin C, a known inhibitor of the Inositol 1,4,5-trisphosphate receptor (IP3R) channel and was unaffected by the phospholipase C (PLC) inhibitor, U73122.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	202-208	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-133
32178876-0	2020	C6-ceramide induces salivary adenoid cystic carcinoma cell apoptosis via IP3R-activated UPR and UPR-independent pathways.	N-caproylsphingosine	0-11	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	73-77
32178876-6	2020	We found that inositol 1,4,5-trisphosphate receptor 3 (IP3R3) was activated, leading to Ca2+ release from ER, soon after c6-ceramide treatment.	N-caproylsphingosine	121-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	55-60
32120195-1	2020	The outer mitochondrial membrane protein VDAC interacts with the ER protein IP3R via chaperone Grp75 to form a molecular complex that couples mitochondria to the ER and contributes to functional mitochondria-ER contacts (MERCs), essential for efficient calcium (Ca2+) transfer.	Calcium	253-260	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-80
32425799-6	2020	Mechanistically, CSE initially induced intracellular reactive oxygen species (ROS) production, which then triggered ER stress, leading to the release of Ca2+ from ER inositol trisphosphate receptor (IP3R)-mediated stores and finally cell death.	Reactive Oxygen Species	53-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	199-203
32202681-4	2020	Water transport is activated and, IP3 R, TRPA1, TRPV4, and Aquaporin-4 are all involved in shaping the dynamics of infrared pulse-evoked intracellular calcium signal.	Calcium	151-158	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	34-39
32425799-6	2020	Mechanistically, CSE initially induced intracellular reactive oxygen species (ROS) production, which then triggered ER stress, leading to the release of Ca2+ from ER inositol trisphosphate receptor (IP3R)-mediated stores and finally cell death.	Reactive Oxygen Species	78-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	199-203
32061592-8	2020	Besides, the results of transendothelial resistance measurement, paracellular flux assay and immunofluorescence showed that procaine induced H1R-dependent hyperpermeability, which involved in PLCgamma/IP3R/PKC, ERK1/2, Akt signaling pathways, downstream vascular endothelial cadherin (VE-cad) destabilization.	Procaine	124-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	201-205
32006470-0	2020	Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3.	Melatonin	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-100
32006470-5	2020	Further, renal IRI induces phosphorylation of inositol 1,4,5-trisphosphate receptor (IP3R) and expression of mitochondrial calcium uniporter (MCU), resulting in cytoplasmic calcium overload and mitochondrial calcium accumulation.	Inositol 1,4,5-Trisphosphate	46-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-89
32006470-5	2020	Further, renal IRI induces phosphorylation of inositol 1,4,5-trisphosphate receptor (IP3R) and expression of mitochondrial calcium uniporter (MCU), resulting in cytoplasmic calcium overload and mitochondrial calcium accumulation.	Calcium	173-180	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-89
32006470-7	2020	Melatonin also inhibits IP3R phosphorylation and MCU expression, thereby alleviating cytoplasmic and mitochondrial calcium overload.	Melatonin	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	24-28
32006470-7	2020	Melatonin also inhibits IP3R phosphorylation and MCU expression, thereby alleviating cytoplasmic and mitochondrial calcium overload.	Calcium	115-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	24-28
31941719-7	2020	formation in cells supplemented with inositol-1,4,5-trisphosphate receptor (IP3R) or ryanodine receptor (RyR) agonists.	Inositol 1,4,5-Trisphosphate	37-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-80
31941719-10	2020	The dramatic anticipation of, sensitization to, the effects of arsenite caused by the IP3R or RyR agonists was accompanied by a parallel significant genotoxic response in the absence of detectable mitochondrial dysfunction and cytotoxicity.	Arsenites	63-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-90
31941719-18	2020	Indeed, a brief exposure to nanomolar levels of arsenite produced maximal effects under conditions in which the [Ca2+]m was increased by IP3R or RyR agonists.	Arsenites	48-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	137-141
31941719-18	2020	Indeed, a brief exposure to nanomolar levels of arsenite produced maximal effects under conditions in which the [Ca2+]m was increased by IP3R or RyR agonists.	Calcium	113-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	137-141
31865041-2	2020	Yet, recent studies (Rezuchova et al, Cell Death Dis, 2019; Ueasilamongkol et al, Hepathology, 2019; Guerra et al, Gut, 2019) revealed that IP3R3 upregulation drives oncogenesis via ER-mitochondrial Ca2+ crosstalk, adding complexity to IP3R3"s role in cancer.	Calcium	199-203	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-145
32363317-6	2020	Hepatocytes began to express the type 3 isoform of the inositol trisphosphate receptor (ITPR3), an intracellular calcium (Ca2+) channel that is not normally expressed in hepatocytes.	Calcium	113-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	88-93
32165828-6	2020	Bioinformatics analysis of miRNA microarray and proteomics data predicted that six out of seven miRNAs are associated with aqueous humor outflow by targeting integrin and the downstream pathways (Src/Rho kinase, focal adhesion kinase (FAK)/NO-cGMP), and one miRNA might influence gap junction by targeting the Inositol trisphosphate receptor (IP3R) /Protein kinase C (PKC) pathway.	Cyclic GMP	243-247	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	343-347
31730387-1	2020	In the body, extracellular stimuli produce inositol 1,4,5-trisphosphate (IP3), an intracellular chemical signal that binds to the IP3 receptor (IP3R) to release calcium ions (Ca2+) from the endoplasmic reticulum.	Inositol 1,4,5-Trisphosphate	43-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-142
32004455-5	2020	IP3 receptor, gap junction, and mechanosensitive calcium channel TRPC1 are involved in calcium wave.	Calcium	87-94	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-12
32071168-7	2020	In enamel cells, fluoride exposure affected the functioning of the ER-localized Ca2+ channel IP3R and the activity of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) pump during Ca2+ refilling of the ER.	Fluorides	17-25	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-97
32071168-7	2020	In enamel cells, fluoride exposure affected the functioning of the ER-localized Ca2+ channel IP3R and the activity of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) pump during Ca2+ refilling of the ER.	Calcium	80-84	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-97
31730387-1	2020	In the body, extracellular stimuli produce inositol 1,4,5-trisphosphate (IP3), an intracellular chemical signal that binds to the IP3 receptor (IP3R) to release calcium ions (Ca2+) from the endoplasmic reticulum.	Inositol 1,4,5-Trisphosphate	43-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	144-148
31730387-1	2020	In the body, extracellular stimuli produce inositol 1,4,5-trisphosphate (IP3), an intracellular chemical signal that binds to the IP3 receptor (IP3R) to release calcium ions (Ca2+) from the endoplasmic reticulum.	Inositol 1,4,5-Trisphosphate	73-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-142
31730387-1	2020	In the body, extracellular stimuli produce inositol 1,4,5-trisphosphate (IP3), an intracellular chemical signal that binds to the IP3 receptor (IP3R) to release calcium ions (Ca2+) from the endoplasmic reticulum.	Inositol 1,4,5-Trisphosphate	73-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	144-148
31730387-1	2020	In the body, extracellular stimuli produce inositol 1,4,5-trisphosphate (IP3), an intracellular chemical signal that binds to the IP3 receptor (IP3R) to release calcium ions (Ca2+) from the endoplasmic reticulum.	Calcium	161-168	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-142
31730387-1	2020	In the body, extracellular stimuli produce inositol 1,4,5-trisphosphate (IP3), an intracellular chemical signal that binds to the IP3 receptor (IP3R) to release calcium ions (Ca2+) from the endoplasmic reticulum.	Calcium	161-168	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	144-148
31730387-3	2020	Recent cryo-electron microscopy and X-ray crystallography have resolved IP3R structures and begun to integrate with concurrent functional studies, which can explicate IP3-dependent opening of Ca2+-conducting gates placed ~90 A away from IP3-binding sites and its regulation by Ca2+.	Inositol 1,4,5-Trisphosphate	167-170	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-76
31906414-4	2020	During the initiation of cell death, numerous vacuoles formed from ER cisterns in the cytoplasm, and cell death was partially suppressed by the inhibitors of protein synthesis and folding, the IP3 receptor inhibitor as well as by thiols.	Sulfhydryl Compounds	230-236	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	193-205
31915246-4	2020	Here, we report structural findings of the human type-3 IP3R (IP3R-3) obtained by cryo-EM (at an overall resolution of 3.8 A), revealing an unanticipated regulatory mechanism where a loop distantly located in the primary sequence occupies the IP3-binding site and competitively inhibits IP3 binding.	Inositol 1,4,5-Trisphosphate	56-59	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-68
31915246-4	2020	Here, we report structural findings of the human type-3 IP3R (IP3R-3) obtained by cryo-EM (at an overall resolution of 3.8 A), revealing an unanticipated regulatory mechanism where a loop distantly located in the primary sequence occupies the IP3-binding site and competitively inhibits IP3 binding.	Inositol 1,4,5-Trisphosphate	62-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-60
31915246-5	2020	We propose that this inhibitory mechanism must differ qualitatively among IP3R subtypes because of their diverse loop sequences, potentially serving as a key molecular determinant of subtype-specific calcium signaling in IP3Rs.	Calcium	200-207	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-78
31915246-6	2020	In summary, our structural characterization of human IP3R-3 provides critical insights into the mechanistic function of IP3Rs and into subtype-specific regulation of these important calcium-regulatory channels.	Calcium	182-189	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	53-59
31646513-1	2020	The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a Ca2+-release channel mainly located in the endoplasmic reticulum (ER).	Inositol 1,4,5-Trisphosphate	4-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	34-47
31646513-1	2020	The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a Ca2+-release channel mainly located in the endoplasmic reticulum (ER).	Inositol 1,4,5-Trisphosphate	4-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
31501196-4	2020	Receptor signaling initiates in the PM via phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), and culminates with the activation of IP3R in the ER.	Phosphatidylinositol 4,5-Diphosphate	88-125	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-176
31501196-4	2020	Receptor signaling initiates in the PM via phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), and culminates with the activation of IP3R in the ER.	Phosphatidylinositol 4,5-Diphosphate	127-131	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-176
31672514-11	2020	CONCLUSIONS AND IMPLICATIONS: This study illustrated the use of quercetin for the treatment of allergic conjunctivitis, which might act through its ability to inhibit Lyn/PLCgamma/IP3R-Ca2+, Lyn/ERK1/2, and Lyn/NF-kappaB signaling.	Quercetin	64-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	180-184
31672514-7	2020	Quercetin also inhibited DNP-HSA/IgE induced Lyn/PLCgamma/IP3R-Ca2+ activation, Lyn/ERK1/2 signaling, and Lyn/NF-kappaB activation in LAD2 cells, all of which promote inflammation.	Quercetin	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
31672514-11	2020	CONCLUSIONS AND IMPLICATIONS: This study illustrated the use of quercetin for the treatment of allergic conjunctivitis, which might act through its ability to inhibit Lyn/PLCgamma/IP3R-Ca2+, Lyn/ERK1/2, and Lyn/NF-kappaB signaling.	Calcium	185-189	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	180-184
31672514-7	2020	Quercetin also inhibited DNP-HSA/IgE induced Lyn/PLCgamma/IP3R-Ca2+ activation, Lyn/ERK1/2 signaling, and Lyn/NF-kappaB activation in LAD2 cells, all of which promote inflammation.	Calcium	63-67	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
31773574-5	2020	Here we describe a fast, high-throughput FP assay to quantify the binding of fluorescently labeled inositol 1,4,5-trisphosphate (IP3) to N-terminal fragments of the IP3 receptor.	Inositol 1,4,5-Trisphosphate	99-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	165-177
31773574-5	2020	Here we describe a fast, high-throughput FP assay to quantify the binding of fluorescently labeled inositol 1,4,5-trisphosphate (IP3) to N-terminal fragments of the IP3 receptor.	Nitrogen	137-138	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	165-177
32115550-7	2020	Various potent IP3 receptor ligands, which were designed using the d-glucose structure as a bioisostere of the myo-inositol moiety of IP3, have been identified.	Glucose	67-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	15-27
32115550-7	2020	Various potent IP3 receptor ligands, which were designed using the d-glucose structure as a bioisostere of the myo-inositol moiety of IP3, have been identified.	Inositol	111-123	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	15-27
31920549-2	2019	Striatal neurons exhibit spontaneous slow Ca2+ oscillations that result from Ca2+ release from the endoplasmic reticulum (ER) induced by the mGluR5-IP3R signaling cascade.	Calcium	42-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	148-152
31920549-2	2019	Striatal neurons exhibit spontaneous slow Ca2+ oscillations that result from Ca2+ release from the endoplasmic reticulum (ER) induced by the mGluR5-IP3R signaling cascade.	Calcium	77-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	148-152
31920549-5	2019	SOCCs are opened by activating the metabotropic glutamate receptor type 5 and inositol 1,4,5-trisphosphate receptor (mGluR5-IP3R) signal transduction cascade and are related to the pathophysiology of several neurological disorders.	Glutamic Acid	48-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	124-128
31920549-5	2019	SOCCs are opened by activating the metabotropic glutamate receptor type 5 and inositol 1,4,5-trisphosphate receptor (mGluR5-IP3R) signal transduction cascade and are related to the pathophysiology of several neurological disorders.	Inositol 1,4,5-Trisphosphate	78-106	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	124-128
31984176-0	2019	Allosteric response to ligand binding: Molecular dynamics study of the N-terminal domains in IP 3 receptor.	Nitrogen	71-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-106
31614139-4	2019	Additionally, morin hydrate attenuated the phosphorylations of phospholipase Cgamma2 (PLCgamma2), cytosolic phospholipase A2 (cPLA2), phosphoinositide 3-kinase (PI3K), Akt, c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK), and enhanced the phosphorylations of inositol trisphosphate receptor (IP3 receptor) and cyclic adenosine monophosphate (cAMP) generation.	morin	14-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	322-335
31817172-6	2019	We further found that GEF stimulated hyaluronic acid (HA) release from HDFs in a dose- and time-dependent manner, which could be attenuated by Ki16425, U73122, a phospholipase C inhibitor, 2-Aminoethoxydiphenyl borate (2-APB), an IP3 receptor antagonist, and BAPTA-AM.	Hyaluronic Acid	54-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	230-242
31817172-6	2019	We further found that GEF stimulated hyaluronic acid (HA) release from HDFs in a dose- and time-dependent manner, which could be attenuated by Ki16425, U73122, a phospholipase C inhibitor, 2-Aminoethoxydiphenyl borate (2-APB), an IP3 receptor antagonist, and BAPTA-AM.	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	143-150	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	230-242
31585052-7	2019	Analysis of the inositol-1,4,5-trisphosphate (IP3) pathway revealed reduced IP3 receptor phosphorylation after KH7 application, which also prevented [Ca2+]i elevation induced by IP3 receptor agonist adenophostin A.	Inositol 1,4,5-Trisphosphate	16-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-88
31585052-7	2019	Analysis of the inositol-1,4,5-trisphosphate (IP3) pathway revealed reduced IP3 receptor phosphorylation after KH7 application, which also prevented [Ca2+]i elevation induced by IP3 receptor agonist adenophostin A.	Inositol 1,4,5-Trisphosphate	16-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	178-190
31585052-7	2019	Analysis of the inositol-1,4,5-trisphosphate (IP3) pathway revealed reduced IP3 receptor phosphorylation after KH7 application, which also prevented [Ca2+]i elevation induced by IP3 receptor agonist adenophostin A.	Calcium	150-154	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-88
31585052-7	2019	Analysis of the inositol-1,4,5-trisphosphate (IP3) pathway revealed reduced IP3 receptor phosphorylation after KH7 application, which also prevented [Ca2+]i elevation induced by IP3 receptor agonist adenophostin A.	Calcium	150-154	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	178-190
31585052-7	2019	Analysis of the inositol-1,4,5-trisphosphate (IP3) pathway revealed reduced IP3 receptor phosphorylation after KH7 application, which also prevented [Ca2+]i elevation induced by IP3 receptor agonist adenophostin A.	adenophostin A	199-213	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-88
31585052-7	2019	Analysis of the inositol-1,4,5-trisphosphate (IP3) pathway revealed reduced IP3 receptor phosphorylation after KH7 application, which also prevented [Ca2+]i elevation induced by IP3 receptor agonist adenophostin A.	adenophostin A	199-213	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	178-190
31920512-8	2019	The GPER antagonist G15, the PLC inhibitor U73122 and the IP3 receptor inhibitor 2-APB each virtually abolished the calcium responses to E2 or G-1.	2-aminoethoxydiphenyl borate	81-86	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-70
31920512-8	2019	The GPER antagonist G15, the PLC inhibitor U73122 and the IP3 receptor inhibitor 2-APB each virtually abolished the calcium responses to E2 or G-1.	Calcium	116-123	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-70
31767755-6	2019	Furthermore, DJ-1 ablation disturbed calcium efflux-induced IP3R3 degradation after carbachol treatment and caused IP3R3 accumulation at the MAM in vitro.	Calcium	37-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-65
31767755-6	2019	Furthermore, DJ-1 ablation disturbed calcium efflux-induced IP3R3 degradation after carbachol treatment and caused IP3R3 accumulation at the MAM in vitro.	Calcium	37-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-120
31767755-6	2019	Furthermore, DJ-1 ablation disturbed calcium efflux-induced IP3R3 degradation after carbachol treatment and caused IP3R3 accumulation at the MAM in vitro.	Carbachol	84-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-65
31984176-1	2019	Inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a huge tetrameric intracellular Ca2+ channel that mediates cytoplasmic Ca2+ signaling.	Inositol 1,4,5-Trisphosphate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-43
31984176-1	2019	Inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a huge tetrameric intracellular Ca2+ channel that mediates cytoplasmic Ca2+ signaling.	Inositol 1,4,5-Trisphosphate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-49
31984176-1	2019	Inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a huge tetrameric intracellular Ca2+ channel that mediates cytoplasmic Ca2+ signaling.	Calcium	86-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-43
31984176-1	2019	Inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a huge tetrameric intracellular Ca2+ channel that mediates cytoplasmic Ca2+ signaling.	Calcium	86-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-49
31984176-1	2019	Inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a huge tetrameric intracellular Ca2+ channel that mediates cytoplasmic Ca2+ signaling.	Calcium	125-129	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-43
31984176-1	2019	Inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a huge tetrameric intracellular Ca2+ channel that mediates cytoplasmic Ca2+ signaling.	Calcium	125-129	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-49
31984176-3	2019	Here, we conducted molecular dynamics (MD) simulations of the three N-terminal domains of IP3R responsible for IP3 binding (IBC/SD; two domains of the IP3 binding core, IBCbeta and IBCalpha, and suppressor domain, SD) as a model system to study the initial gating stage.	Nitrogen	68-69	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
31597594-8	2019	Importantly, ITPR3, a key component of calcium signaling in epithelial cells, that has previously shown to be downregulated in SS SG, was directly targeted and downregulated by miR-1248, inducing the same functional calcium signaling changes as observed in SS SGs.	Calcium	39-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	13-18
31597594-8	2019	Importantly, ITPR3, a key component of calcium signaling in epithelial cells, that has previously shown to be downregulated in SS SG, was directly targeted and downregulated by miR-1248, inducing the same functional calcium signaling changes as observed in SS SGs.	Calcium	216-223	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	13-18
31425510-6	2019	Here, we propose an IP3R-mediated calcium signaling model for dynamics in such small sub-cellular volumes.	Calcium	34-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-24
31247352-7	2019	Patients with SAH and DCI had significantly higher levels of methylation intensity of distal IGR upstream of ITPR3 than those without DCI (median, 0.941 [interquartile range (IQR), 0.857-0.984] versus (0.670 [IQR, 0.543-0.761]; P < 0.001).	dci	22-25	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-114
31247352-8	2019	In addition, patients with DCI showed decreased mRNA expression of ITPR3 compared with patients without DCI (median, 0.039 [IQR, 0.030-0.045] vs. 0.047 [IQR, 0.038-0.064]; P = 0.0328).	dci	27-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	67-72
31247352-10	2019	CONCLUSIONS: Hypermethylation of the distal IGR located upstream of ITPR3 is related to greater DCI development in patients with SAH.	dci	96-99	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	68-73
31425510-9	2019	The model reproduces the main forms of calcium signals and indicates that their frequency crucially depends on the spatial organization of the IP3R channels.	Calcium	39-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	143-147
31427578-0	2019	IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.	Calcium	79-86	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-12
30999216-10	2019	Blocking release of calcium from internal stores by loading cells with the IP3 receptor blocker heparin (1 mM) or the ryanodine receptor blocker dantrolene (20 muM) abolished both the calcium transients and the facilitation of evoked synaptic currents induced by dopamine.	Dopamine	263-271	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	75-87
31427578-1	2019	Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival.	Calcium	76-83	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	104-117
31427578-1	2019	Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival.	Calcium	76-83	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	119-123
31427578-5	2019	We also show that, while each isoform can support contacts, type 2 IP3R is the most effective in delivering calcium to the mitochondria.	Calcium	108-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	67-71
30999216-10	2019	Blocking release of calcium from internal stores by loading cells with the IP3 receptor blocker heparin (1 mM) or the ryanodine receptor blocker dantrolene (20 muM) abolished both the calcium transients and the facilitation of evoked synaptic currents induced by dopamine.	Calcium	20-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	75-87
30999216-10	2019	Blocking release of calcium from internal stores by loading cells with the IP3 receptor blocker heparin (1 mM) or the ryanodine receptor blocker dantrolene (20 muM) abolished both the calcium transients and the facilitation of evoked synaptic currents induced by dopamine.	Heparin	96-103	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	75-87
31153638-6	2019	The combined application of progesterone (1 muM medroxyprogesterone acetate) and cyclic AMP (0.5 mM) for 6 days not only elevated inositol 1,4,5-triphosphate receptor (IP3R)-mediated Ca2+ release and IP3R expression, it also promoted ORAI and STIM expression as well as cyclopiazonic acid-induced Ca2+ release.	Progesterone	28-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	168-172
31153638-6	2019	The combined application of progesterone (1 muM medroxyprogesterone acetate) and cyclic AMP (0.5 mM) for 6 days not only elevated inositol 1,4,5-triphosphate receptor (IP3R)-mediated Ca2+ release and IP3R expression, it also promoted ORAI and STIM expression as well as cyclopiazonic acid-induced Ca2+ release.	Progesterone	28-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	200-204
31153638-6	2019	The combined application of progesterone (1 muM medroxyprogesterone acetate) and cyclic AMP (0.5 mM) for 6 days not only elevated inositol 1,4,5-triphosphate receptor (IP3R)-mediated Ca2+ release and IP3R expression, it also promoted ORAI and STIM expression as well as cyclopiazonic acid-induced Ca2+ release.	Medroxyprogesterone Acetate	48-75	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	168-172
31153638-6	2019	The combined application of progesterone (1 muM medroxyprogesterone acetate) and cyclic AMP (0.5 mM) for 6 days not only elevated inositol 1,4,5-triphosphate receptor (IP3R)-mediated Ca2+ release and IP3R expression, it also promoted ORAI and STIM expression as well as cyclopiazonic acid-induced Ca2+ release.	Cyclic AMP	81-91	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	168-172
31153638-6	2019	The combined application of progesterone (1 muM medroxyprogesterone acetate) and cyclic AMP (0.5 mM) for 6 days not only elevated inositol 1,4,5-triphosphate receptor (IP3R)-mediated Ca2+ release and IP3R expression, it also promoted ORAI and STIM expression as well as cyclopiazonic acid-induced Ca2+ release.	Cyclic AMP	81-91	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	200-204
31203007-7	2019	Moreover, colon cancer cells also display dysregulation of the expression of 1,4,5-triphosphate receptors (IP3R) that could contribute to the enhanced SOCE.	,4,5-triphosphate	78-95	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-111
30999216-10	2019	Blocking release of calcium from internal stores by loading cells with the IP3 receptor blocker heparin (1 mM) or the ryanodine receptor blocker dantrolene (20 muM) abolished both the calcium transients and the facilitation of evoked synaptic currents induced by dopamine.	Calcium	184-191	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	75-87
30877106-5	2019	Moreover, the iEGFR gefitinib activated endoplasmic reticulum calcium channel inositol trisphosphate receptor 3 (IP3R3)-mediated release of calcium, which directly bound menin.	Gefitinib	20-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	113-118
30875538-8	2019	Based on the above experiments, the western blot analyses were conducted, the results indicated that isosalvianolic acid C induced Ca2+ mobilization and degranulation via the activation of PLC-gamma and IP3R, and releasing chemokines via the activation of PLC-gamma, PKC and P38.	isosalvianolic acid C	101-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	203-207
30848934-5	2019	The enhanced ryanodine receptor (RyR)-mediated and inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca2+ release from the ER aggravates cytosolic Ca2+ disorder and triggers apoptosis; the down-regulated ER Ca2+ sensor, stromal interaction molecule (STIM), alleviates store-operated Ca2+ entry in plasma membrane, leading to spine loss.	-trisphosphate	65-79	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
31171961-2	2019	Replacement of the alpha-glucopyranosyl unit of adenophostin A, a potent d-myo-inositol 1,4,5-trisphosphate (IP3R) agonist, with a d-chiro-inositol surrogate acting substantially as a pseudosugar, leads to "d-chiro-inositol adenophostin".	alpha-glucopyranosyl	19-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
31171961-2	2019	Replacement of the alpha-glucopyranosyl unit of adenophostin A, a potent d-myo-inositol 1,4,5-trisphosphate (IP3R) agonist, with a d-chiro-inositol surrogate acting substantially as a pseudosugar, leads to "d-chiro-inositol adenophostin".	adenophostin A	48-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
31171961-2	2019	Replacement of the alpha-glucopyranosyl unit of adenophostin A, a potent d-myo-inositol 1,4,5-trisphosphate (IP3R) agonist, with a d-chiro-inositol surrogate acting substantially as a pseudosugar, leads to "d-chiro-inositol adenophostin".	Inositol	131-147	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
30877106-5	2019	Moreover, the iEGFR gefitinib activated endoplasmic reticulum calcium channel inositol trisphosphate receptor 3 (IP3R3)-mediated release of calcium, which directly bound menin.	Calcium	62-69	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	113-118
30877106-7	2019	Together, these findings uncover a molecular convergence of menin and the iEGFR-induced, IP3R3-mediated calcium release on SKP2 transcription and reveal opportunities to enhance iEGFR efficacy to improve treatments for colorectal cancer.	Calcium	104-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-94
31023176-0	2019	IP3R and RyR channels are involved in traffic-related PM2.5-induced disorders of calcium homeostasis.	Calcium	81-88	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
28961124-9	2019	We also derived a discrete event calcium wave model from a deterministic model using the stochastic $\text{IP}_{3}\text{R}$IP3R structure.	Calcium	33-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	123-127
31023176-6	2019	The [Ca2+]i in Jurkat T cells significantly decreased after treatment with heparin as an inhibitor of inositol trisphosphate receptors (IP3 R), or procaine as an inhibitor of ryanodine receptors (RyR).	Heparin	75-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-141
30792485-0	2019	Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation.	Inositol 1,4,5-Trisphosphate	15-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-105
30764601-0	2019	G-Protein-Coupled Receptor 120 Mediates DHA-Induced Apoptosis by Regulating IP3R, ROS and, ER Stress Levels in Cisplatin-Resistant Cancer Cells.	Docosahexaenoic Acids	40-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-80
30764601-0	2019	G-Protein-Coupled Receptor 120 Mediates DHA-Induced Apoptosis by Regulating IP3R, ROS and, ER Stress Levels in Cisplatin-Resistant Cancer Cells.	Cisplatin	111-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-80
30764601-5	2019	The inositol 1,4,5-triphosphate receptor (IP3R) blocker 2-aminoethyl diphenylboninate (2-APB) reduced DHA-induced ROS production, consequently reducing apoptosis.	2-aminoethyl diphenylboninate	56-85	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-46
30764601-5	2019	The inositol 1,4,5-triphosphate receptor (IP3R) blocker 2-aminoethyl diphenylboninate (2-APB) reduced DHA-induced ROS production, consequently reducing apoptosis.	2-aminoethoxydiphenyl borate	87-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-46
30764601-5	2019	The inositol 1,4,5-triphosphate receptor (IP3R) blocker 2-aminoethyl diphenylboninate (2-APB) reduced DHA-induced ROS production, consequently reducing apoptosis.	Docosahexaenoic Acids	102-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-46
30764601-5	2019	The inositol 1,4,5-triphosphate receptor (IP3R) blocker 2-aminoethyl diphenylboninate (2-APB) reduced DHA-induced ROS production, consequently reducing apoptosis.	Reactive Oxygen Species	114-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-46
30764601-9	2019	These results suggest that GPR120 mediates DHA-induced apoptosis by regulating IP3R, ROS, and ER stress levels in cisplatin-resistant cancer cells, and that GPR120 is an effective chemotherapeutic target for cisplatin resistance.	Docosahexaenoic Acids	43-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-83
30191989-6	2019	Pharmacological manipulation showed that the Ca2+ response to Ach was mediated by InsP3 R3, TPC1-2, and store-operated Ca2+ entry (SOCE).	Acetylcholine	62-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-90
30681867-11	2019	SAgAIns induced a decrease in BCR expression and IP3R-mediated intracellular calcium release.	sagains	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
30681867-11	2019	SAgAIns induced a decrease in BCR expression and IP3R-mediated intracellular calcium release.	Calcium	77-84	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
29899382-2	2019	A peptide tool (Bcl-2/IP3R Disruptor-2; BIRD-2) was developed to abrogate the interaction of Bcl-2 with IP3Rs by targeting Bcl-2"s BH4 domain.	sapropterin	131-134	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-26
29899382-11	2019	Thus, constitutive IP3 signaling in lymphoma and leukemia cells is not only important for cancer cell survival, but also represents a vulnerability, rendering cancer cells dependent on Bcl-2 to limit IP3R activity.	Inositol 1,4,5-Trisphosphate	19-22	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	200-204
30792485-0	2019	Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation.	Inositol 1,4,5-Trisphosphate	45-48	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-105
30792485-1	2019	Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 A away from the IP3-binding core (IBC).	Inositol 1,4,5-Trisphosphate	0-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-83
30792485-1	2019	Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 A away from the IP3-binding core (IBC).	Inositol 1,4,5-Trisphosphate	0-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-89
30792485-1	2019	Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 A away from the IP3-binding core (IBC).	Inositol 1,4,5-Trisphosphate	32-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-83
30792485-1	2019	Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 A away from the IP3-binding core (IBC).	Inositol 1,4,5-Trisphosphate	32-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-89
30792485-1	2019	Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 A away from the IP3-binding core (IBC).	Inositol 1,4,5-Trisphosphate	71-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-89
30792485-2	2019	However, the precise mechanism of IP3 binding and correlated domain dynamics in the NT that are central to the IP3R activation, remains unknown.	Inositol 1,4,5-Trisphosphate	34-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-115
30792485-3	2019	Our all-atom molecular dynamics (MD) simulations recapitulate the characteristic twist motion of the suppressor domain (SD) and reveal correlated "clam closure" dynamics of IBC with IP3-binding, complementing existing suggestions on IP3R activation mechanism.	Inositol 1,4,5-Trisphosphate	182-185	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	233-237
31183833-7	2019	The resultant depolarisation leads to the opening of voltage-dependent Ca2+ channels and possibly increased production of IP3, which through Ca2+-induced Ca2+ release (CICR) of IP3Rs and/or RyRs and IP3R-mediated Ca2+ release provide a means by which store oscillators entrain their activity.	Inositol 1,4,5-Trisphosphate	122-125	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	177-181
30141207-3	2019	We examined effects of endotoxin on expression and function of the type 3 inositol trisphosphate receptor (ITPR3), because this is the main intracellular Ca2+ release channel in cholangiocytes, and loss of it impairs ductular bicarbonate secretion.	Bicarbonates	226-237	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-112
31183833-7	2019	The resultant depolarisation leads to the opening of voltage-dependent Ca2+ channels and possibly increased production of IP3, which through Ca2+-induced Ca2+ release (CICR) of IP3Rs and/or RyRs and IP3R-mediated Ca2+ release provide a means by which store oscillators entrain their activity.	cicr	168-172	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	177-181
29899383-9	2018	Opening of endoplasmic reticulum IP3R calcium channels stimulates cell swelling, cPLA2 activation, and arachidonic acid release.	Arachidonic Acid	103-119	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	33-37
30552138-4	2018	Radioligand binding confirmed that the 4,5-phosphates of IP3 are essential for activating IP3Rs, and facilitated IP3R purification and cloning, which paved the way for structural analyses.	4,5-phosphates	39-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
30552138-4	2018	Radioligand binding confirmed that the 4,5-phosphates of IP3 are essential for activating IP3Rs, and facilitated IP3R purification and cloning, which paved the way for structural analyses.	Inositol 1,4,5-Trisphosphate	57-60	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
30552138-6	2018	Structural analyses are now revealing how IP3 binding to the N-terminus of the tetrameric IP3R opens the pore ~7 nm away from the IP3-binding core (IBC).	Inositol 1,4,5-Trisphosphate	42-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
29619740-9	2018	Our results suggest that nicotine modulates mitochondrial dynamics and influences mitochondrial association from microtubules, increasing IP3 receptor clustering showing modulation between mitochondria-ER communications, together with the increase of mitochondrial biogenesis.	Nicotine	25-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	138-150
30424024-10	2018	Similarly, in addition to PTX/Gallein and U73122, the IP3R inhibitor 2-APB and a 0 mM Ca2+-EGTA solution partially inhibited the elevation of intracellular Ca2+ levels.	2-aminoethoxydiphenyl borate	69-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	54-58
30053503-3	2018	On the other hand, the BH4 domain of Bcl-2 binds to the inositol 1,4,5-trisphosphate receptor (IP3R), preventing Ca2+ signals that mediate cell death.	sapropterin	23-26	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	95-99
30355490-3	2018	Here, we show that the viral protein NS5A forms a trimeric complex with IP3R3 and FBXL2, unmasking IP3R3"s degron in the absence of inositol 1,4,5-trisphosphate (IP3) stimulation.	Inositol 1,4,5-Trisphosphate	72-75	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	99-104
30355490-7	2018	This study reveals an IP3-independent molecular mechanism through which HCV promotes IP3R3 degradation, thereby inhibiting virus-induced apoptosis and establishing chronic infection.	Inositol 1,4,5-Trisphosphate	22-25	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-90
29253316-1	2018	The inositol 1,4,5-trisphosphate receptor (IP3 R) is an intracellular ion channel that mediates the release of calcium ions from the endoplasmic reticulum.	-trisphosphate	18-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	43-48
29253316-1	2018	The inositol 1,4,5-trisphosphate receptor (IP3 R) is an intracellular ion channel that mediates the release of calcium ions from the endoplasmic reticulum.	Calcium	111-118	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	43-48
30185837-0	2018	Association of the IP3R to STIM1 provides a reduced intraluminal calcium microenvironment, resulting in enhanced store-operated calcium entry.	Calcium	65-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-23
30117680-7	2018	These results demonstrate for the first time that bradykinin-mediated increase in free Cai2+ via ER-IP3R3 Ca2+ release followed by Ca2+ influx through SOCE channel plays a crucial role in regulating cell growth and migration via activating pAkt, pERK1/2 and cyclin D1 in human cardiac c-Kit+ progenitor cells.	cai2+	87-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-105
30068729-4	2018	We therefore conclude that arsenite elevates the [Ca2+]i by directly targeting the IP3R and its intraluminal crosstalk with the RyR.	arsenite	27-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	83-87
30185837-7	2018	ER intraluminal calcium measurements using Mag-Fluo-4 showed enhanced calcium depletion when IP3R is overexpressed.	Calcium	16-23	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-97
30185837-0	2018	Association of the IP3R to STIM1 provides a reduced intraluminal calcium microenvironment, resulting in enhanced store-operated calcium entry.	Calcium	128-135	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-23
30185837-7	2018	ER intraluminal calcium measurements using Mag-Fluo-4 showed enhanced calcium depletion when IP3R is overexpressed.	Fluo 4	47-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-97
30185837-1	2018	The involvement of inositol trisphosphate receptor (IP3R) in modulating store-operated calcium entry (SOCE) was established many years ago.	Calcium	87-94	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	52-56
30185837-7	2018	ER intraluminal calcium measurements using Mag-Fluo-4 showed enhanced calcium depletion when IP3R is overexpressed.	Calcium	70-77	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-97
30185837-8	2018	A STIM1-GCaMP fusion protein indicates that STIM1 detects lower calcium concentrations near its EF-hand domain when IP3R is overexpressed when compared with the fluorescence reported by a GCaMP homogenously distributed in the ER lumen (ER-GCaMP).	Calcium	64-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	116-120
30185837-3	2018	In the present study we show that IP3R associates to STIM1 upon depletion of the endoplasmic reticulum (ER) by activation of the inositol trisphosphate signaling cascade via G-protein coupled receptors.	inositol 1,2,3-trisphosphate	129-151	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	34-38
30185837-9	2018	All these data together strongly suggest that activation of inositol trisphosphate signaling cascade induces the formation of the IP3R-STIM1 complex.	inositol 1,2,3-trisphosphate	60-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
30185837-10	2018	The activated IP3R provides a reduced intraluminal calcium microenvironment near STIM1, resulting in enhanced activation of Orai currents and SOCE.	Calcium	51-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	14-18
30185837-4	2018	IP3R-STIM1 association results in enhanced STIM1 puncta formation and larger Orai-mediated whole-cell currents as well as increased calcium influx.	Calcium	132-139	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
30197885-10	2018	Treatment of ciPTEC-PC1KD with 2-APB, an IP3R inhibitor, prevented the rescue of bioenergetics deficit induced by CaSR activation supporting a critical role of IP3Rs in driving ER-to-mitochondria Ca2+ shuttle.	2-aminoethoxydiphenyl borate	31-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	41-45
30120227-4	2018	Induction of calcium levels by inhibition of cathepsin S is markedly blocked by an inhibitor of the IP3 receptor and the ryanodine receptor Ca2+ channel in the ER, but an inhibitor of a mitochondrial Ca2+ uniporter had no effect on ZFL-induced calcium levels.	Calcium	13-20	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-112
29323715-0	2018	Alleviation of palmitic acid-induced endoplasmic reticulum stress by augmenter of liver regeneration through IP3R-controlled Ca2+ release.	Palmitic Acid	15-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
29323715-5	2018	The treatment of HepG2 cells with palmitic acid (PA) upregulated IP3R expression, triggering ER-luminal Ca2+ release and inducing ER stress.	Palmitic Acid	34-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-69
29323715-5	2018	The treatment of HepG2 cells with palmitic acid (PA) upregulated IP3R expression, triggering ER-luminal Ca2+ release and inducing ER stress.	Palmitic Acid	49-51	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-69
29323715-7	2018	After exposure to PA, IP3R expression was downregulated and ER stress was effectively inhibited in the ALR-Tx cells, and ER-Ca2+ release and simultaneous mitochondrial Ca2+ uptake were lower than those in vector-Tx cells.	Palmitic Acid	18-20	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-26
29323715-9	2018	PA treatment also suppressed the interaction between BCL-2 and IP3R in HepG2 cells, whereas this interaction was massively enhanced in the ALR-Tx cells, effectively reducing the IP3R-mediated ER-Ca2+ release and thus mitochondrial Ca2+ influx.	Palmitic Acid	0-2	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
29323715-9	2018	PA treatment also suppressed the interaction between BCL-2 and IP3R in HepG2 cells, whereas this interaction was massively enhanced in the ALR-Tx cells, effectively reducing the IP3R-mediated ER-Ca2+ release and thus mitochondrial Ca2+ influx.	Palmitic Acid	0-2	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	178-182
29676177-12	2018	CONCLUSIONS: These results indicate that the regulatory mechanism of the Ach-induced ciliary beat is dependent on extracellular Ca2+ and involves the muscarinic Ach receptor, IP3 receptor, pannexin-1 channel, purinergic P2X receptor, and connexin channel.	Acetylcholine	73-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	175-187
30093868-8	2018	Several lines of evidence implicate changes in expression/function levels of IP3R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging.	vsmc	127-131	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	77-81
30197841-1	2018	Calcium release into the cytosol via the inositol 1,4,5-trisphosphate receptor (IP3R) calcium channel is important for a variety of cellular processes.	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-84
29630900-8	2018	IP3R3 silencing revealed an oscillatory calcium signature, with a predominant oscillating profile occurring in early wound repair.	Calcium	40-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-5
29988564-0	2018	Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism.	Calcium	14-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	51-55
29988564-1	2018	Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single skeletal muscle fibers; this calcium increase would couple muscle fiber excitation to an increase in metabolic output from mitochondria (excitation-metabolism coupling).	Potassium	199-208	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	67-79
29988564-1	2018	Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single skeletal muscle fibers; this calcium increase would couple muscle fiber excitation to an increase in metabolic output from mitochondria (excitation-metabolism coupling).	Potassium	199-208	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-85
29988564-1	2018	Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single skeletal muscle fibers; this calcium increase would couple muscle fiber excitation to an increase in metabolic output from mitochondria (excitation-metabolism coupling).	Calcium	87-94	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	67-79
29988564-1	2018	Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single skeletal muscle fibers; this calcium increase would couple muscle fiber excitation to an increase in metabolic output from mitochondria (excitation-metabolism coupling).	Calcium	87-94	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-85
29988564-6	2018	Mitochondrial Ca2+ uptake required functional inositol IP3R and RyR1 channels.	Inositol	46-54	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	55-59
29287955-7	2018	Another regulatory protein of IP3R, IP3R-binding protein released with IP3 (IRBIT), cooperates with or counteracts the Bcl-2 family member depending on cellular states.	Inositol 1,4,5-Trisphosphate	30-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	36-40
30090602-7	2018	By utilizing the IP3R inhibitor 2-aminoethyldiphenylborate (2-APB) and SOCC inhibitor YM-58483, we found that the increase of Cr(vi)-induced cytosolic-free Ca2+ depended on IP3R-mediated Ca2+ release from the ER and SOCC-mediated Ca2+ influx from the extracellular space.	2-aminoethyldiphenylborate	32-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	17-21
30090602-9	2018	We reached the conclusion that IP3R-SOCCs played an important role in Cr(vi)-induced Ca2+ overload and apoptotic cell death in the hepatocytes, which will provide experimental evidence for the research on the exogenous chemical-induced Ca2+ overload of hepatocytes, and for the prevention and early treatment of liver damage in a Cr(vi)-exposed population.	chromium hexavalent ion	70-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	31-35
29413844-0	2018	Ripk3 regulates cardiac microvascular reperfusion injury: The role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action/filopodia-based cellular migration.	Calcium	85-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-74
29413844-6	2018	The higher IP3R content was associated with cellular calcium overload, and increased XO expression was involved in cellular oxidative injury.	Calcium	53-60	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	11-15
29413844-7	2018	Furthermore, IP3R-mediated calcium overload and XO-dependent oxidative damage were able to initiate cellular apoptosis.	Calcium	27-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	13-17
29413844-9	2018	Altogether, our data confirmed that Ripk3 was involved in microvascular IR injury via regulation of IP3R-mediated calcium overload, XO-dependent oxidative damage and filopodia-related cellular migration, ultimately leading to endothelial apoptosis and migratory inhibition.	Calcium	114-121	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-104
30090602-9	2018	We reached the conclusion that IP3R-SOCCs played an important role in Cr(vi)-induced Ca2+ overload and apoptotic cell death in the hepatocytes, which will provide experimental evidence for the research on the exogenous chemical-induced Ca2+ overload of hepatocytes, and for the prevention and early treatment of liver damage in a Cr(vi)-exposed population.	chromium hexavalent ion	330-336	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	31-35
30090602-7	2018	By utilizing the IP3R inhibitor 2-aminoethyldiphenylborate (2-APB) and SOCC inhibitor YM-58483, we found that the increase of Cr(vi)-induced cytosolic-free Ca2+ depended on IP3R-mediated Ca2+ release from the ER and SOCC-mediated Ca2+ influx from the extracellular space.	2-aminoethyldiphenylborate	32-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	173-177
30090602-7	2018	By utilizing the IP3R inhibitor 2-aminoethyldiphenylborate (2-APB) and SOCC inhibitor YM-58483, we found that the increase of Cr(vi)-induced cytosolic-free Ca2+ depended on IP3R-mediated Ca2+ release from the ER and SOCC-mediated Ca2+ influx from the extracellular space.	2-aminoethoxydiphenyl borate	60-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	17-21
30090602-7	2018	By utilizing the IP3R inhibitor 2-aminoethyldiphenylborate (2-APB) and SOCC inhibitor YM-58483, we found that the increase of Cr(vi)-induced cytosolic-free Ca2+ depended on IP3R-mediated Ca2+ release from the ER and SOCC-mediated Ca2+ influx from the extracellular space.	Chromium	126-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	17-21
30090602-7	2018	By utilizing the IP3R inhibitor 2-aminoethyldiphenylborate (2-APB) and SOCC inhibitor YM-58483, we found that the increase of Cr(vi)-induced cytosolic-free Ca2+ depended on IP3R-mediated Ca2+ release from the ER and SOCC-mediated Ca2+ influx from the extracellular space.	Chromium	126-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	173-177
29330143-5	2018	Mechanistic investigations showed that Nrh made BH4 domain-dependent interactions with the ligand-binding domain of the inositol-1,4,5-triphosphate receptor (IP3R), a type 1/3 Ca2+ channel, allowing Nrh to negatively regulate ER-Ca2+ release and to mediate antiapoptosis.	sapropterin	48-51	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	158-162
29706890-8	2018	The SV-enhanced phosphorylation of PKC was sensitive to the IP3R antagonist 2-APB.	2-aminoethoxydiphenyl borate	76-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-64
29920471-5	2018	The STIM1/Orai1-mediated SOC entry is the main cause of a sustained intracellular calcium ([Ca2+]i) elevation, which is different from a transient rise of [Ca2+]i mediated by IP3R and RyR.	Calcium	82-89	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	175-179
29330143-6	2018	Notably, disrupting Nrh/IP3R complexes by BH4 mimetic peptides was sufficient to inhibit the growth of breast cancer cells in vitro and in vivo Taken together, our results highlighted Nrh as a novel prognostic marker and a candidate therapeutic target for late stage breast cancers that may be addicted to Nrh.Significance: These findings offer a comprehensive molecular model for the activity of Nrh/BCL2L10, a little studied antiapoptotic molecule, prognostic marker, and candidate drug target in breast cancer.	sapropterin	42-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	24-28
29131377-9	2018	These findings identify the previously unknown role of FKBP12 in female reproduction which contributes to the release of calcium via IP3 R channel and might open up new strategies for women who want to bear a baby after transplantation.	Calcium	121-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	133-138
29456837-5	2018	However, this assumption does not consider IP3 Diffusion Coefficient (Dab), that activates IP3 Receptor (IP3R) releasing Ca2+ from intracellular stores.	Inositol 1,4,5-Trisphosphate	43-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	91-103
29456837-5	2018	However, this assumption does not consider IP3 Diffusion Coefficient (Dab), that activates IP3 Receptor (IP3R) releasing Ca2+ from intracellular stores.	Inositol 1,4,5-Trisphosphate	43-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-109
29456837-5	2018	However, this assumption does not consider IP3 Diffusion Coefficient (Dab), that activates IP3 Receptor (IP3R) releasing Ca2+ from intracellular stores.	diazobenzenesulfonic acid	70-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	91-103
29456837-5	2018	However, this assumption does not consider IP3 Diffusion Coefficient (Dab), that activates IP3 Receptor (IP3R) releasing Ca2+ from intracellular stores.	diazobenzenesulfonic acid	70-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-109
29456837-8	2018	The model predicts that IP3 concentration near the Ca2+ stores may activate IP3R, depending upon Phospholipase C (PLC) number and activity.	Inositol 1,4,5-Trisphosphate	24-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-80
29386119-4	2018	This effect requires the SH3-HOOK domain of Cavbeta3, includes physical beta3/IP3 receptor interaction, and prevails when agonist-induced IP3 formation is bypassed by photolysis of caged IP3.	Inositol 1,4,5-Trisphosphate	138-141	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-90
29207009-0	2018	TAT-fused IP3R-derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release.	Cisplatin	40-49	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	10-14
28669047-0	2018	Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca2+]c/VDAC-[Ca2+]m axis by activation of MAPK/ERK signaling pathway.	Melatonin	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-115
28669047-4	2018	We found that oxidative stress induced by H2O2 significantly activated cAMP response element binding protein (CREB) that enhanced IP3R and VDAC transcription and expression, leading to [Ca2+]c and [Ca2+]m overload.	Hydrogen Peroxide	42-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
28669047-6	2018	However, melatonin could protect CMECs against oxidative stress injury via stimulation of MAPK/ERK that inactivated CREB and therefore blocked IP3R/VDAC upregulation and [Ca2+]c/[Ca2+]m overload, sustaining mitochondrial structural and function integrity and ultimately blockading mitochondrial-mediated cellular death.	Melatonin	9-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	143-147
28803370-5	2017	Binding of IP3 to the IP3Rs initiates assembly of IP3R clusters, a key event responsible for amplification of Ca2+ signals in endothelial cells.	Inositol 1,4,5-Trisphosphate	11-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-26
28105751-6	2017	2-aminoethoxydiphenyl borate (2-APB), a dual non-competitive antagonist of IP3R and inhibitor of SOCE, decreased Ang-II-induced Ca2+ release and attenuated Ang-II-induced enhanced expression of Egr-1 protein and mRNA levels.	2-aminoethoxydiphenyl borate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	75-79
28105751-6	2017	2-aminoethoxydiphenyl borate (2-APB), a dual non-competitive antagonist of IP3R and inhibitor of SOCE, decreased Ang-II-induced Ca2+ release and attenuated Ang-II-induced enhanced expression of Egr-1 protein and mRNA levels.	2-aminoethoxydiphenyl borate	30-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	75-79
29340082-4	2017	Indeed, Bcl-2 via its BH4 domain prevents cytotoxic Ca2+ release from the endoplasmic reticulum (ER) by directly inhibiting the inositol 1,4,5-trisphosphate receptor (IP3R).	sapropterin	22-25	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	167-171
29340082-5	2017	The cell-permeable Bcl-2/IP3R disruptor-2 (BIRD-2) peptide can kill these Bcl-2-dependent cancers by targeting Bcl-2"s BH4 domain, unleashing pro-apoptotic Ca2+-release events.	sapropterin	119-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	25-29
28105751-3	2017	Ang-II elevates intracellular Ca2+ through activation of the store-operated calcium entry (SOCE) involving an inositol-3-phosphate receptor (IP3R)-coupled depletion of endoplasmic reticular Ca2+ and a subsequent activation of the stromal interaction molecule 1 (STIM-1)/Orai-1 complex.	Calcium	76-83	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
29040664-11	2017	Consistent with those results, treatment of JAR and JEG3 cells with a Ca2+ chelator and an inhibitor of IP3 receptor decreased coumestrol-induced depolarization of MMP and increased proliferation in JAR and JEG3 cells.	Coumestrol	127-137	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	104-116
28709993-0	2017	Intracellular calcium release through IP3R or RyR contributes to secondary axonal degeneration.	Calcium	14-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	38-42
29031723-10	2017	High glucose and FAs reduced endoplasmic reticulum (ER) Ca2+ storage capacity; however, preserving ER Ca2+ by blocking the IP3 receptor with xestospongin C did not protect islets from glucolipotoxic effects on insulin secretion.	xestospongin C	141-155	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	123-135
28644055-9	2017	In freshly-isolated human DSM cells, blocking the IP3Rs with the selective IP3R inhibitor xestospongin-C significantly decreased TICCs.	xestospongin C	90-104	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
28644055-9	2017	In freshly-isolated human DSM cells, blocking the IP3Rs with the selective IP3R inhibitor xestospongin-C significantly decreased TICCs.	ticcs	129-134	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
29069790-5	2017	We show that a higher IP3R3 expression level, but not IP3R1 nor IP3R2, is correlated to a stronger cell line migration capacity and a sustained calcium signal.	Calcium	144-151	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-27
28506554-5	2017	PD-induced calcium transience can be blocked by a calcium chelator, such as BAPTA-AM, or by pre-treatment of neurons with thapsigargin, a IP3 receptor antagonist, or a micromolar concentration of ryanodine, a ryanodine receptor (RyR) antagonist.	N-((4-(2-cyanophenyl)-1-piperazinyl)methyl)-3-methylbenzamide	0-2	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	138-150
28506554-5	2017	PD-induced calcium transience can be blocked by a calcium chelator, such as BAPTA-AM, or by pre-treatment of neurons with thapsigargin, a IP3 receptor antagonist, or a micromolar concentration of ryanodine, a ryanodine receptor (RyR) antagonist.	Calcium	11-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	138-150
28506554-7	2017	These results indicate that the calcium response induced by DR4 activation is mainly through activation of IP3 receptor in internal stores, which is likely to contribute to the DA modulation of synaptic transmission and cognitive function.	Calcium	32-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-119
29069790-6	2017	Interestingly, silencing of IP3R3 highlights an oscillating calcium signaling profile and leads to a significant decrease of cell migration capacities of the three breast cancer cell lines.	Calcium	60-67	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-33
29069790-9	2017	In conclusion, we demonstrate that IP3R3 expression level increases the migration capacity of human breast cancer cells by changing the calcium signature.	Calcium	136-143	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-40
28412247-5	2017	Furthermore, GL-V9 increased mitochondrial Ca2+ uptake through 1,4,5-triphosphate (IP3) receptor via the activation of phospholipase C-gamma1 and the translocation of phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase from nucleus to endoplasmic reticulum.	phosphatidylinositol 3,4,5-triphosphate	167-207	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	83-96
28506928-2	2017	Previously, we reported that integration of a cGMP-specific cyclic nucleotide phosphodiesterase, namely phosphodiesterase 5A (PDE5A), into a protein kinase G (PKG)- and inositol-1,4,5-trisphosphate receptor (IP3R)-containing endoplasmic reticulum (ER) signalosome allows localized control of PDE5A activity and of PKG-dependent inhibition of IP3-mediated release of ER Ca2+ in human platelets.	Cyclic GMP	46-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	208-212
28106298-4	2017	Inhibiting IP3 R sub types resulted in compromised bioenergetics both in terms of glucose and mitochondrial metabolism.	Glucose	82-89	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	11-16
28106298-5	2017	The siRNA mediated silencing of IP3 R or its blocking by its inhibitors Xestospongin C and 2-Amino-ethoxy diphenyl borate increased cell death and LC3II expression in MCF-7 cells as well as attenuated cellular bioenergetics.	xestospongin C	72-86	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	32-37
28106298-5	2017	The siRNA mediated silencing of IP3 R or its blocking by its inhibitors Xestospongin C and 2-Amino-ethoxy diphenyl borate increased cell death and LC3II expression in MCF-7 cells as well as attenuated cellular bioenergetics.	2-aminoethoxydiphenyl borate	91-121	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	32-37
28106298-8	2017	Inhibiting as well as silencing of IP3 R receptor also resulted in increase in ROS production which was abolished after pretreatment with N-acetyl cysteine.	ros	79-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-40
28751862-20	2017	Conclusion: UTP activates a predominant P2Y4R pathway to trigger Ca2+oscillations via internal Ca2+mobilization through a PLC/IP3/IP3R/SERCA Ca2+signaling pathway to stimulate 5-HT release; Ca2+influx is inhibitory.	Uridine Triphosphate	12-15	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
28179072-4	2017	Orai3 channel, but neither Orai1 nor Orai2, colocalizes with expressed IP3R and only Orai3 channel supported the 2-APB-induced ER Ca2+ leak, while Orai1 and Orai2 inhibited this type of ER Ca2+ leak.	2-aminoethoxydiphenyl borate	113-118	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-75
28106298-8	2017	Inhibiting as well as silencing of IP3 R receptor also resulted in increase in ROS production which was abolished after pretreatment with N-acetyl cysteine.	Acetylcysteine	138-155	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-40
28106298-9	2017	Its role in autophagy was confirmed through decrease in the levels of LC3 II after pretreatment with IP3 R inhibitor and N acetyl cysteine.Moreover, inhibiting as well as silencing IP3 R-induced cell death in MCF-7 cells was attenuated by autophagic inhibitors (Bafilomycin A1 or 3-Methyladeneine).	Acetylcysteine	121-138	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	181-186
28106298-9	2017	Its role in autophagy was confirmed through decrease in the levels of LC3 II after pretreatment with IP3 R inhibitor and N acetyl cysteine.Moreover, inhibiting as well as silencing IP3 R-induced cell death in MCF-7 cells was attenuated by autophagic inhibitors (Bafilomycin A1 or 3-Methyladeneine).	bafilomycin A1	262-276	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-106
28106298-9	2017	Its role in autophagy was confirmed through decrease in the levels of LC3 II after pretreatment with IP3 R inhibitor and N acetyl cysteine.Moreover, inhibiting as well as silencing IP3 R-induced cell death in MCF-7 cells was attenuated by autophagic inhibitors (Bafilomycin A1 or 3-Methyladeneine).	bafilomycin A1	262-276	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	181-186
28106298-9	2017	Its role in autophagy was confirmed through decrease in the levels of LC3 II after pretreatment with IP3 R inhibitor and N acetyl cysteine.Moreover, inhibiting as well as silencing IP3 R-induced cell death in MCF-7 cells was attenuated by autophagic inhibitors (Bafilomycin A1 or 3-Methyladeneine).	3-methyladeneine	280-296	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-106
28106298-9	2017	Its role in autophagy was confirmed through decrease in the levels of LC3 II after pretreatment with IP3 R inhibitor and N acetyl cysteine.Moreover, inhibiting as well as silencing IP3 R-induced cell death in MCF-7 cells was attenuated by autophagic inhibitors (Bafilomycin A1 or 3-Methyladeneine).	3-methyladeneine	280-296	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	181-186
27887748-2	2017	IP3 levels induce Ca2+ release from the endoplasmic reticulum (ER) via IP3 receptor (IP3R) located in the ER membrane.	Inositol 1,4,5-Trisphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-83
28614305-9	2017	Here, it binds, deubiquitylates, and stabilizes type 3 inositol-1,4,5-trisphosphate receptor (IP3R3), modulating calcium (Ca2+) release from the endoplasmic reticulum into the cytosol and mitochondria, promoting apoptosis.	Calcium	113-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	94-99
27887748-2	2017	IP3 levels induce Ca2+ release from the endoplasmic reticulum (ER) via IP3 receptor (IP3R) located in the ER membrane.	Inositol 1,4,5-Trisphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-89
27887748-4	2017	Therefore, monitoring and manipulating IP3 levels is important to elucidate not only the functions of IP3-mediated pathways but also the encoding mechanism of IP3R as a converter of intracellular signals from IP3 to Ca2+.	Inositol 1,4,5-Trisphosphate	39-42	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-163
28196740-10	2017	IP3Rs partly contributed to the DPB162-AE-induced Ca2+ leak, since pharmacologically and genetically inhibiting IP3R function reduced, but not completely blocked, the effects of DPB162-AE on the ER store content.	dpb162	32-38	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
28570539-3	2017	The dynamic release of calcium from these organelles is mediated by the ryanodine receptor (RyR) and the inositol 1,4,5-triphosphate receptor (IP3R) with refilling occurring through the sarco/endoplasmic reticulum calcium ATPase (SERCA) pump.	Calcium	23-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	143-147
28570539-7	2017	With this method, a decrease in ER calcium is seen with RyR activation with 4-chloro-m-cresol (4-cmc), the indirect activation of IP3R with adenosine triphosphate (ATP), and inhibition of the SERCA pump with cyclopiazonic acid (CPA).	Calcium	35-42	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
28570539-7	2017	With this method, a decrease in ER calcium is seen with RyR activation with 4-chloro-m-cresol (4-cmc), the indirect activation of IP3R with adenosine triphosphate (ATP), and inhibition of the SERCA pump with cyclopiazonic acid (CPA).	Adenosine Triphosphate	140-162	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
28570539-7	2017	With this method, a decrease in ER calcium is seen with RyR activation with 4-chloro-m-cresol (4-cmc), the indirect activation of IP3R with adenosine triphosphate (ATP), and inhibition of the SERCA pump with cyclopiazonic acid (CPA).	Adenosine Triphosphate	164-167	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
28570539-7	2017	With this method, a decrease in ER calcium is seen with RyR activation with 4-chloro-m-cresol (4-cmc), the indirect activation of IP3R with adenosine triphosphate (ATP), and inhibition of the SERCA pump with cyclopiazonic acid (CPA).	cyclopiazonic acid	208-226	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
28570539-7	2017	With this method, a decrease in ER calcium is seen with RyR activation with 4-chloro-m-cresol (4-cmc), the indirect activation of IP3R with adenosine triphosphate (ATP), and inhibition of the SERCA pump with cyclopiazonic acid (CPA).	cyclopiazonic acid	228-231	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
28012441-7	2017	Blocking Ca2+ mobilization, PLC, or IP3R diminished UgU-induced IL-1beta release, caspase-1 activation, and mitochondrial ROS generation.	Reactive Oxygen Species	122-125	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	36-40
28538151-4	2017	In this article, using a stochastic puff model and a single-channel data-based IP3R model, we establish the dependencies of lambda and xi on two important IP3R model parameters, IP3 concentration ([IP3]) and the recovery rate from Ca2+ inhibition (rlow).	Inositol 1,4,5-Trisphosphate	155-158	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-83
28538151-6	2017	The two combinations utilize very different mechanisms to maintain the same IPI distribution, and the mechanistic difference provides a way of identifying IP3R kinetic parameters by observing properties of the IPI.	diprotin A	210-213	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	155-159
28196740-10	2017	IP3Rs partly contributed to the DPB162-AE-induced Ca2+ leak, since pharmacologically and genetically inhibiting IP3R function reduced, but not completely blocked, the effects of DPB162-AE on the ER store content.	DPB162-AE	32-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
26642860-1	2017	OBJECTIVE: Caffeine reduces toxic Ca2+ signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP).	Caffeine	11-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	131-135
27936394-5	2017	TAT-conjugated IP3R-derived peptide (TAT-IDPS) increased cisplatin-induced iNOS expression and apoptosis in SKOV3/DDP cells.	Cisplatin	57-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	15-19
26642860-2	2017	We have determined effects of caffeine and its xanthine metabolites on pancreatic acinar IP3R-mediated Ca2+ signalling and experimental AP.	Caffeine	30-38	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-93
26642860-12	2017	CONCLUSIONS: Caffeine and its dimethylxanthine metabolites reduced pathological IP3R-mediated pancreatic acinar Ca2+ signals but only caffeine ameliorated experimental AP.	Caffeine	13-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-84
26642860-12	2017	CONCLUSIONS: Caffeine and its dimethylxanthine metabolites reduced pathological IP3R-mediated pancreatic acinar Ca2+ signals but only caffeine ameliorated experimental AP.	Theophylline	30-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-84
28122214-1	2017	Calcium cycling between the sarcoplasmic reticulum (SR) and the cytosol via the sarco-/endoplasmic reticulum Ca-ATPase (SERCA) pump, inositol-1,4,5-triphosphate receptor (IP3R), and Ryanodine receptor (RyR), plays a major role in agonist-induced intracellular calcium ([Ca2+]cyt) dynamics in vascular smooth muscle cells (VSMC).	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	171-175
28122214-5	2017	Model results show that agonist-induced intracellular calcium dynamics can be modified by changing the levels of SERCA, IP3R, and/or RyR.	Calcium	54-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	120-124
28122214-6	2017	Lowering SERCA level will enable intracellular calcium oscillations at low agonist concentrations whereas lowered levels of IP3R and RyR need higher agonist concentration for intracellular calcium oscillations.	Calcium	189-196	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	124-128
27979909-8	2016	The inferred parameter distribution predicts, and experiments confirm that variability in IP3R response explains the majority of calcium heterogeneity.	Calcium	129-136	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
29017172-4	2017	As a calcium binding protein, the roles of CIB1 in calcium signaling by binding calcium or modulating some key modulators, such as calcineurin, integrin, inositol 1,4,5-trisphosphate receptor (IP3R) and taste 1 receptor member 2 (TAS1R2).	Calcium	51-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	193-197
29017172-4	2017	As a calcium binding protein, the roles of CIB1 in calcium signaling by binding calcium or modulating some key modulators, such as calcineurin, integrin, inositol 1,4,5-trisphosphate receptor (IP3R) and taste 1 receptor member 2 (TAS1R2).	Calcium	51-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	193-197
29201062-4	2017	We provide evidence for the existence of intracellular calcium stores that respond to muscarinic activation of the cells, having sensitivity for ryanodine and thapsigargin possibly reflecting IP3 receptor activity and the presence of ryanodine receptors and calcium ATPase pumps.	Calcium	55-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	192-204
29201062-4	2017	We provide evidence for the existence of intracellular calcium stores that respond to muscarinic activation of the cells, having sensitivity for ryanodine and thapsigargin possibly reflecting IP3 receptor activity and the presence of ryanodine receptors and calcium ATPase pumps.	Thapsigargin	159-171	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	192-204
28072864-10	2017	We observed an increase in lipoprotein content and the levels of metabolites like lactate, lysine and alanine and a decrease in the levels of pyruvate and glucose in serum of high IP3R group patients when compared to those in healthy subjects.	Pyruvic Acid	142-150	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	180-184
28072864-10	2017	We observed an increase in lipoprotein content and the levels of metabolites like lactate, lysine and alanine and a decrease in the levels of pyruvate and glucose in serum of high IP3R group patients when compared to those in healthy subjects.	Glucose	155-162	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	180-184
27941214-3	2016	In hMESCs sublethal H2O2-treatment resulted in a rapid calcium release from intracellular stores mediated by the activation of PLC/IP3/IP3R pathway.	Hydrogen Peroxide	20-24	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	135-139
27995898-1	2016	IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.	Inositol 1,4,5-Trisphosphate	44-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-113
27995898-1	2016	IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.	Inositol 1,4,5-Trisphosphate	44-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-119
27995898-1	2016	IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.	Inositol 1,4,5-Trisphosphate	74-77	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-113
27995898-1	2016	IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.	Inositol 1,4,5-Trisphosphate	74-77	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-119
27995898-1	2016	IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.	Inositol 1,4,5-Trisphosphate	101-104	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-119
27941214-3	2016	In hMESCs sublethal H2O2-treatment resulted in a rapid calcium release from intracellular stores mediated by the activation of PLC/IP3/IP3R pathway.	Calcium	55-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	135-139
27941214-3	2016	In hMESCs sublethal H2O2-treatment resulted in a rapid calcium release from intracellular stores mediated by the activation of PLC/IP3/IP3R pathway.	Inositol 1,4,5-Trisphosphate	131-134	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	135-139
25758670-8	2016	Moreover, the CSE-induced intracellular calcium increase was suppressed by pretreatment with the inositol trisphosphate receptor (IP3R) inhibitor xestospongin C, the phospholipase C (PLC) inhibitor U-73122, and the protein kinase C (PKC) inhibitor GF109203X.	Calcium	40-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
27841000-2	2016	The authors of the present study hypothesized that a mutation in beta-amyloid precursor protein (APP), which is a gene associated with familial Alzheimer"s disease, may render cells vulnerable to isoflurane-induced cytotoxicity via activation of inositol 1,4,5-trisphosphate receptors (IP3R).	Isoflurane	196-206	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	286-290
27841000-5	2016	Treatment with isoflurane (1 MAC) for 8 h induced a higher degree of cytotoxicity, and a marked increase in [Ca2+]c and IP3R protein levels in mutated APP-transfected SH-SY5Y cells compared with vector-transfected SH-SY5Y cells.	Isoflurane	15-25	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	120-124
28066549-3	2016	Adenophostin A (AdA) is a potent agonist of IP3R and since some dimeric analogs of IP3R ligands are more potent than the corresponding monomer; we considered whether dimeric AdA analogs might provide agonists with increased potency.	adenophostin A	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	44-48
28066549-3	2016	Adenophostin A (AdA) is a potent agonist of IP3R and since some dimeric analogs of IP3R ligands are more potent than the corresponding monomer; we considered whether dimeric AdA analogs might provide agonists with increased potency.	adenophostin A	16-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	44-48
25758670-8	2016	Moreover, the CSE-induced intracellular calcium increase was suppressed by pretreatment with the inositol trisphosphate receptor (IP3R) inhibitor xestospongin C, the phospholipase C (PLC) inhibitor U-73122, and the protein kinase C (PKC) inhibitor GF109203X.	xestospongin C	146-160	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
27444647-2	2016	To determine the subtype-specific IP3-binding mechanism, we compared the thermodynamics, thermal stability, and conformational dynamics between the N-terminal regions of IP3R1 (IP3R1-NT) and IP3R3 (IP3R3-NT) by performing circular dichroism (CD), isothermal titration calorimetry (ITC), and hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Inositol 1,4,5-Trisphosphate	34-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	191-196
27444647-3	2016	Previously determined crystal structures of IP3R1-NT and HDX-MS results from this study revealed that both IP3R1 and IP3R3 adopt a similar IP3-binding mechanism.	Inositol 1,4,5-Trisphosphate	44-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-122
27235833-9	2016	Thus, hemichannels activated downstream of an alphaVbeta3 integrin-PI3K-PLCgamma-IP3R pathway are responsible for Thy-1-induced, hemichannel-mediated and Syndecan-4-modulated ATP release that transactivates P2X7Rs to induce Ca(2+) entry.	Adenosine Triphosphate	175-178	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-85
27198223-4	2016	Using reverse phase protein array (RPPA) and in-depth analysis of key stress signaling components, we observed that PAR formation induced by H2O2 was mediated by the PLC/IP3R/Ca(2+)/PKCalpha signaling axis.	Hydrogen Peroxide	141-145	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	170-174
27098757-13	2016	In contrast, both IP3R2 and IP3R3 contributed to UTP-induced Ca(2+) responses while ATP-induced Ca(2+) responses were more dependent on IP3R2 in the CVPCs.	Uridine Triphosphate	49-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-33
27235833-5	2016	Results obtained indicate that ATP was released by Thy-1 upon integrin engagement and required the participation of phosphatidylinositol-3-kinase (PI3K), phospholipase-C gamma (PLCgamma) and inositol trisphosphate (IP3) receptors (IP3R).	Adenosine Triphosphate	31-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	231-235
27235833-6	2016	IP3R activation leads to increased intracellular Ca(2+), hemichannel (Connexin-43 and Pannexin-1) opening, and ATP release.	hemichannel	57-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
27235833-6	2016	IP3R activation leads to increased intracellular Ca(2+), hemichannel (Connexin-43 and Pannexin-1) opening, and ATP release.	Adenosine Triphosphate	111-114	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
27235833-9	2016	Thus, hemichannels activated downstream of an alphaVbeta3 integrin-PI3K-PLCgamma-IP3R pathway are responsible for Thy-1-induced, hemichannel-mediated and Syndecan-4-modulated ATP release that transactivates P2X7Rs to induce Ca(2+) entry.	hemichannel	6-17	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-85
27184076-2	2016	They affect intracellular Ca(2+) homeostasis by increasing the open probability (Po) of inositol 1,4,5-trisposphate (IP3) receptor (IP3R) Ca(2+) release channel located on the endoplasmic reticulum (ER) leading to exaggerated Ca(2+) release into a cytoplasmic microdomain formed by neighboring cluster of a few IP3R channels and mitochondrial Ca(2+) uniporter (MCU).	inositol 1,4,5-trisposphate	88-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-130
27430888-4	2016	Furthermore, following the addition of exogenous ATP, an inositol trisphosphate receptor (IP3R) agonist, small Ca(2+) transients were generated from day 1 onward.	Adenosine Triphosphate	49-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
27430888-5	2016	That ATP was inducing Ca(2+) release from functional IP3Rs was demonstrated by treatment with 2-APB, a known IP3R antagonist.	Adenosine Triphosphate	5-8	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	53-57
27430888-5	2016	That ATP was inducing Ca(2+) release from functional IP3Rs was demonstrated by treatment with 2-APB, a known IP3R antagonist.	2-aminoethoxydiphenyl borate	94-99	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	53-57
27494888-4	2016	In contrast, the deletion of the C-terminus, containing the trans-membrane domain, which is only present in Bcl-2alpha, but not in Bcl-2beta, led to impaired inhibition of IP3R-mediated Ca2+ release and staurosporine-induced apoptosis.	Staurosporine	203-216	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-176
27494888-6	2016	We therefore propose a novel model, in which the Bcl-2"s C-terminus serves as a functional anchor, which beyond mere ER-membrane targeting, underlies efficient IP3R inhibition by (i) positioning the BH4 domain in the close proximity of its binding site on IP3R, thus facilitating their interaction; (ii) inhibiting IP3R-channel openings through a direct interaction with the C-terminal region of the channel downstream of the channel-pore.	sapropterin	199-202	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	160-164
27494888-6	2016	We therefore propose a novel model, in which the Bcl-2"s C-terminus serves as a functional anchor, which beyond mere ER-membrane targeting, underlies efficient IP3R inhibition by (i) positioning the BH4 domain in the close proximity of its binding site on IP3R, thus facilitating their interaction; (ii) inhibiting IP3R-channel openings through a direct interaction with the C-terminal region of the channel downstream of the channel-pore.	sapropterin	199-202	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	256-260
27494888-6	2016	We therefore propose a novel model, in which the Bcl-2"s C-terminus serves as a functional anchor, which beyond mere ER-membrane targeting, underlies efficient IP3R inhibition by (i) positioning the BH4 domain in the close proximity of its binding site on IP3R, thus facilitating their interaction; (ii) inhibiting IP3R-channel openings through a direct interaction with the C-terminal region of the channel downstream of the channel-pore.	sapropterin	199-202	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	256-260
27184076-2	2016	They affect intracellular Ca(2+) homeostasis by increasing the open probability (Po) of inositol 1,4,5-trisposphate (IP3) receptor (IP3R) Ca(2+) release channel located on the endoplasmic reticulum (ER) leading to exaggerated Ca(2+) release into a cytoplasmic microdomain formed by neighboring cluster of a few IP3R channels and mitochondrial Ca(2+) uniporter (MCU).	inositol 1,4,5-trisposphate	88-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	132-136
27184076-2	2016	They affect intracellular Ca(2+) homeostasis by increasing the open probability (Po) of inositol 1,4,5-trisposphate (IP3) receptor (IP3R) Ca(2+) release channel located on the endoplasmic reticulum (ER) leading to exaggerated Ca(2+) release into a cytoplasmic microdomain formed by neighboring cluster of a few IP3R channels and mitochondrial Ca(2+) uniporter (MCU).	inositol 1,4,5-trisposphate	88-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	311-315
27155879-4	2016	These mitochondrial changes appear to be IP3R3-dependent and resulted in decreased NAD/NADH ratios and higher electron transport chain oxidase activity.	NAD	83-86	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	41-46
27189081-6	2016	The stretch-induced Ca(2+) oscillations were greatly inhibited by the selective inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor xestospongin C and partially inhibited by ryanodine.	xestospongin C	135-149	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	119-123
27155879-4	2016	These mitochondrial changes appear to be IP3R3-dependent and resulted in decreased NAD/NADH ratios and higher electron transport chain oxidase activity.	NAD	87-91	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	41-46
27155879-6	2016	Indeed, confocal analysis indicated that Bcl-xL translocated to the MAM and increased its interaction with IP3R3 following extended Tg treatment.	Thapsigargin	132-134	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-112
26492105-8	2016	Taken together our results show that IP3 R and ryanodine receptor mediated release of Ca(2+) from the ER and its subsequent influx through the uniporter into mitochondria contributes to hesperidin-induced paraptosis in HepG2 cells.	Hesperidin	186-196	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	37-42
27048564-2	2016	Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.	Inositol 1,4,5-Trisphosphate	64-67	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	104-108
26592972-3	2016	The key event in activation of fluid secretion is an increase in [Ca(2+) ]i triggered by inositol 1,4,5-trisphosphate (IP3 )-induced release of Ca(2+) from ER via the IP3 receptor (IP3 R).	Inositol 1,4,5-Trisphosphate	89-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	167-179
26592972-3	2016	The key event in activation of fluid secretion is an increase in [Ca(2+) ]i triggered by inositol 1,4,5-trisphosphate (IP3 )-induced release of Ca(2+) from ER via the IP3 receptor (IP3 R).	Inositol 1,4,5-Trisphosphate	89-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	181-186
26592972-3	2016	The key event in activation of fluid secretion is an increase in [Ca(2+) ]i triggered by inositol 1,4,5-trisphosphate (IP3 )-induced release of Ca(2+) from ER via the IP3 receptor (IP3 R).	Inositol 1,4,5-Trisphosphate	119-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	167-179
26592972-3	2016	The key event in activation of fluid secretion is an increase in [Ca(2+) ]i triggered by inositol 1,4,5-trisphosphate (IP3 )-induced release of Ca(2+) from ER via the IP3 receptor (IP3 R).	Inositol 1,4,5-Trisphosphate	119-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	181-186
27048566-10	2016	These data provide definitive evidence that IP3-induced Ca(2+)release only occurs when each IP3R monomer within the tetramer is occupied by IP3, thereby ensuring fidelity of Ca(2+)release.	Inositol 1,4,5-Trisphosphate	44-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	92-96
27048564-2	2016	Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.	Inositol 1,4,5-Trisphosphate	64-67	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	220-224
27048564-2	2016	Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.	ip3before	119-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	104-108
27048564-2	2016	Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.	ip3before	119-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	220-224
27048564-2	2016	Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.	ip3and	213-219	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	104-108
27048564-2	2016	Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.	ip3and	213-219	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	220-224
26868821-9	2016	Changes in a calcium homeostasis result from IP3 receptor s up-regulation and down-regulation of the SERCA 2, which leads to a development of the endoplasmic reticulum stress.	Calcium	13-20	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-57
26980664-4	2016	Poly(I:C) exposure rather than LPS incubation not only elevated inositol 1,4,5-triphosphate receptor (IP3R) expression and IP3R-mediated Ca(2+) release, but also promoted Orai and STIM expression as well as store-operated Ca(2+) entry into hMSCs.	poly	0-4	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	102-106
26980664-4	2016	Poly(I:C) exposure rather than LPS incubation not only elevated inositol 1,4,5-triphosphate receptor (IP3R) expression and IP3R-mediated Ca(2+) release, but also promoted Orai and STIM expression as well as store-operated Ca(2+) entry into hMSCs.	poly	0-4	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	123-127
26755721-1	2016	The ability of inositol 1,4,5-trisphosphate receptors (IP3R) to precisely initiate and generate a diverse variety of intracellular Ca(2+) signals is in part mediated by the differential regulation of the three subtypes (R1, R2, and R3) by key functional modulators (IP3, Ca(2+), and ATP).	Adenosine Triphosphate	283-286	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	55-59
26755721-5	2016	Under conditions where key regulators of IP3R function are optimal for Ca(2+) release, we demonstrate that individual monomers within heteromeric IP3Rs contributed equally toward generating a distinct "blended" sensitivity to IP3 that is likely dictated by the unique IP3 binding affinity of the heteromers.	Inositol 1,4,5-Trisphosphate	146-149	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	41-45
26755721-10	2016	In summary, we demonstrate that heterotetrameric IP3R do not necessarily behave as the sum of the constituent subunits, and these properties likely extend the versatility of IP3-induced Ca(2+) signaling in cells expressing multiple IP3R isoforms.	Inositol 1,4,5-Trisphosphate	49-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	232-236
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol triphosphate	99-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	143-155
26884398-6	2016	We found that PLC/IP3/IP3R/Ryr1/Ca(2+) signaling is widely active in fetal DMD skeletal muscles and, through the calcium-dependent PKCalpha protein, exerts a fundamental regulatory role in delaying myogenesis and in myofiber commitment.	Calcium	113-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-26
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol triphosphate	99-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	157-161
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol triphosphate	99-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-202
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol 1,4,5-Trisphosphate	122-125	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	143-155
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol 1,4,5-Trisphosphate	122-125	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	157-161
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol 1,4,5-Trisphosphate	122-125	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-202
26551735-6	2016	While blocking the increase in intracellular Ca(2+) by locking the IP3R calcium channel with 2-APB had no effect on EGF activation of the ERK or AKT signaling pathways, it abolished the rapid EGF-mediated induction and repression of gene expression.	2-aminoethoxydiphenyl borate	93-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	67-71
27160165-9	2016	These results indicate that chloroquine, via the Gbetax03B3;-PLC-IP3-IP3R pathway, induces elevation of Ca2+, and this Ca2+ increase does not play a role in chloroqui-ne-evoked GTPM increase.	Chloroquine	28-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	69-73
26857816-7	2016	Pretreatment with a PLC inhibitor or an IP3 receptor antagonist reduced changes in resistance and permeability suggesting activation of sAC occurred through increased intracellular calcium.	Calcium	181-188	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-52
26206086-7	2016	We demonstrated that both pharmacological and genetic inhibition of GSK3beta decreased protein interaction of IP3R with the Ca(2+) channeling complex, impaired SR/ER Ca(2+) release and reduced the histamine-stimulated Ca(2+) exchange between SR/ER and mitochondria in cardiomyocytes.	Histamine	197-206	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
27160165-12	2016	CONCLUSION: Our data indicate that chloroquine via Gbetax03B3;-PLC-IP3-IP3R induces Ca2+ elevation, which in turn promotes GLUT4 fusion with the PM.	Chloroquine	35-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-75
26439382-1	2015	Familial Alzheimer"s disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+) release channels resulting in enhanced IP3R channel gating in an amyloid beta (Abeta) production-independent manner.	Inositol 1,4,5-Trisphosphate	81-109	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-124
26720343-3	2015	SCLC cells often overexpress Bcl-2, which protects cells from apoptosis both by sequestering pro-apoptotic family members and by modulating inositol 1,4,5-trisphosphate receptor (IP3R)-mediated calcium signaling.	Calcium	194-201	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	179-183
26344105-0	2015	Evidence that NO/cGMP/PKG signalling cascade mediates endothelium dependent inhibition of IP3R mediated Ca2+ oscillations in myocytes and pericytes of ureteric microvascular network in situ.	Cyclic GMP	17-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
26344105-11	2015	The inhibitory effect of NO/cGMP/PKG cascade is associated with suppressed Ca(2+) release from the SR of myocytes and pericytes selectively via the inositol triphosphate receptor (IP3R) channels.	Cyclic GMP	28-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	180-184
26497496-2	2015	In addition, it is suggested that the mechanism of spatial association of synaptic plasticity is based on intracellular calcium signaling that is mainly regulated by two types of receptors of endoplasmic reticulum calcium store: the ryanodine receptor (RyR) and the inositol triphosphate receptor (IP3R).	Calcium	120-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	298-302
26497496-2	2015	In addition, it is suggested that the mechanism of spatial association of synaptic plasticity is based on intracellular calcium signaling that is mainly regulated by two types of receptors of endoplasmic reticulum calcium store: the ryanodine receptor (RyR) and the inositol triphosphate receptor (IP3R).	Calcium	214-221	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	298-302
26439382-1	2015	Familial Alzheimer"s disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+) release channels resulting in enhanced IP3R channel gating in an amyloid beta (Abeta) production-independent manner.	Inositol 1,4,5-Trisphosphate	81-109	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-130
26439382-1	2015	Familial Alzheimer"s disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+) release channels resulting in enhanced IP3R channel gating in an amyloid beta (Abeta) production-independent manner.	Inositol 1,4,5-Trisphosphate	81-109	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	178-182
26439382-3	2015	In this paper, we employed computational modeling of single IP3R channel activity records obtained under optimal Ca(2+) and multiple IP3 concentrations to gain deeper insights into the enhancement of IP3R function.	Inositol 1,4,5-Trisphosphate	60-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	200-204
26439382-5	2015	The model is then used to extrapolate the behavior of the channel to a wide range of IP3 and Ca(2+) concentrations and quantify the sensitivity of IP3R to its two ligands.	Inositol 1,4,5-Trisphosphate	85-88	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	147-151
26439382-6	2015	We show that the gain-of-function enhancement is sensitive to both IP3 and Ca(2+) and that very small amount of IP3 is required to stimulate IP3R channels in the presence of FAD-causing mutant PS to the same level of activity as channels in control cells stimulated by significantly higher IP3 concentrations.	Inositol 1,4,5-Trisphosphate	112-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
26439382-6	2015	We show that the gain-of-function enhancement is sensitive to both IP3 and Ca(2+) and that very small amount of IP3 is required to stimulate IP3R channels in the presence of FAD-causing mutant PS to the same level of activity as channels in control cells stimulated by significantly higher IP3 concentrations.	Inositol 1,4,5-Trisphosphate	112-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
26317541-4	2015	The current anti-Bcl-2 agents, ABT-263 (Navitoclax) and ABT-199 (Venetoclax), induce apoptosis by displacing pro-apoptotic proteins from the hydrophobic pocket, but do not inhibit Bcl-2-IP3R interaction.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	31-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	186-190
26317541-4	2015	The current anti-Bcl-2 agents, ABT-263 (Navitoclax) and ABT-199 (Venetoclax), induce apoptosis by displacing pro-apoptotic proteins from the hydrophobic pocket, but do not inhibit Bcl-2-IP3R interaction.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	56-59	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	186-190
26317541-5	2015	Therefore, to target this interaction we developed BIRD-2 (Bcl-2 IP3 Receptor Disruptor-2), a decoy peptide that binds to the BH4 domain, blocking Bcl-2-IP3R interaction and thus inducing Ca2+-mediated apoptosis in chronic lymphocytic leukemia, multiple myeloma, and follicular lymphoma cells, including cells resistant to ABT-263, ABT-199, or the Bruton"s tyrosine kinase inhibitor Ibrutinib.	sapropterin	126-129	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	153-157
26317541-5	2015	Therefore, to target this interaction we developed BIRD-2 (Bcl-2 IP3 Receptor Disruptor-2), a decoy peptide that binds to the BH4 domain, blocking Bcl-2-IP3R interaction and thus inducing Ca2+-mediated apoptosis in chronic lymphocytic leukemia, multiple myeloma, and follicular lymphoma cells, including cells resistant to ABT-263, ABT-199, or the Bruton"s tyrosine kinase inhibitor Ibrutinib.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	323-326	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	153-157
26317541-5	2015	Therefore, to target this interaction we developed BIRD-2 (Bcl-2 IP3 Receptor Disruptor-2), a decoy peptide that binds to the BH4 domain, blocking Bcl-2-IP3R interaction and thus inducing Ca2+-mediated apoptosis in chronic lymphocytic leukemia, multiple myeloma, and follicular lymphoma cells, including cells resistant to ABT-263, ABT-199, or the Bruton"s tyrosine kinase inhibitor Ibrutinib.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	332-335	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	153-157
26317541-5	2015	Therefore, to target this interaction we developed BIRD-2 (Bcl-2 IP3 Receptor Disruptor-2), a decoy peptide that binds to the BH4 domain, blocking Bcl-2-IP3R interaction and thus inducing Ca2+-mediated apoptosis in chronic lymphocytic leukemia, multiple myeloma, and follicular lymphoma cells, including cells resistant to ABT-263, ABT-199, or the Bruton"s tyrosine kinase inhibitor Ibrutinib.	ibrutinib	383-392	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	153-157
26088141-7	2015	Expression of alpha7345-348A, however, did significantly attenuate the alpha7 nAChR-induced Galphaq calcium signaling response as evidenced by a decrease in PLC-beta activation and IP3R-mediated calcium store release in the presence of the alpha7 selective agonist choline.	Calcium	195-202	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	181-185
26393489-0	2015	Shared functional defect in IP3R-mediated calcium signaling in diverse monogenic autism syndromes.	Calcium	42-49	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-32
26393489-5	2015	This was apparent in Ca(2+) signals evoked by G protein-coupled receptors and by photoreleased IP3 at the levels of both global and local elementary Ca(2+) events, suggesting fundamental defects in IP3R channel activity in ASD.	Inositol 1,4,5-Trisphosphate	95-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-202
26108728-9	2015	An agonist of inositol 1,4,5-trisphosphate receptor (IP3R) was used to investigate the mechanism of dexamethasone-induced autophagy.	Dexamethasone	100-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	53-57
26108728-14	2015	Furthermore, our results showed that dexamethasone induced autophagy via suppressing the phosphorylation of IP3R.	Dexamethasone	37-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	108-112
26100947-9	2015	Exposure to KN-93 strongly diminished ER Ca(2+) content (-61%) by relieving CaMKII-dependent inhibition of IP3 receptors (IP3R).	KN 93	12-17	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-120
26100947-9	2015	Exposure to KN-93 strongly diminished ER Ca(2+) content (-61%) by relieving CaMKII-dependent inhibition of IP3 receptors (IP3R).	KN 93	12-17	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-126
26115837-6	2015	Moreover, fluoxetine was found to deplete intracellular Ca(2+) stores, thereby leaving less Ca(2+) available for release upon IP3- and ryanodine-receptor activation.	Fluoxetine	10-20	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-153
26115837-8	2015	In conclusion, these data show that fluoxetine decreases IP3- and ryanodine-receptor mediated Ca(2+) release in Jurkat T lymphocytes, an effect likely to be at the basis of the observed immunosuppression.	Fluoxetine	36-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	57-84
26142955-5	2015	After the addition of both PGE2 and PGF2alpha calcium activity in the PVCs was significantly reduced by both the SERCA inhibitor CPA and the IP3R antagonist 2-APB, but the changes in calcium activity were unrelated to the changes in tone induced by PGE2 and PGF2alpha.	Dinoprostone	27-31	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
26142955-5	2015	After the addition of both PGE2 and PGF2alpha calcium activity in the PVCs was significantly reduced by both the SERCA inhibitor CPA and the IP3R antagonist 2-APB, but the changes in calcium activity were unrelated to the changes in tone induced by PGE2 and PGF2alpha.	Dinoprost	36-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
26142955-5	2015	After the addition of both PGE2 and PGF2alpha calcium activity in the PVCs was significantly reduced by both the SERCA inhibitor CPA and the IP3R antagonist 2-APB, but the changes in calcium activity were unrelated to the changes in tone induced by PGE2 and PGF2alpha.	Calcium	46-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
26142955-5	2015	After the addition of both PGE2 and PGF2alpha calcium activity in the PVCs was significantly reduced by both the SERCA inhibitor CPA and the IP3R antagonist 2-APB, but the changes in calcium activity were unrelated to the changes in tone induced by PGE2 and PGF2alpha.	2-aminoethoxydiphenyl borate	157-162	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
25911230-10	2015	These data indicate strongly that CO.IP3R-A as an exemplar of ancestral IP3R-A orthologs forms bona fide IP3-gated channels.	Carbon Monoxide	34-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	37-41
25911230-10	2015	These data indicate strongly that CO.IP3R-A as an exemplar of ancestral IP3R-A orthologs forms bona fide IP3-gated channels.	Carbon Monoxide	34-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-76
25911230-10	2015	These data indicate strongly that CO.IP3R-A as an exemplar of ancestral IP3R-A orthologs forms bona fide IP3-gated channels.	Inositol 1,4,5-Trisphosphate	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-76
25921245-8	2015	In summary, IP3R-mediated ER Ca(2+) release promoted the elevations of [Ca(2+)]c and [Ca(2+)]mit in Pb-exposed rPT cells, which played a chief role in apoptosis induced by impaired calcium homeostasis.	Lead	100-102	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	12-16
26077147-12	2015	Thus, we identify a novel mechanism by which cocaine promotes activation of D1-expressing nAcc neurons: enhancement of IP3R-mediated responses via sigma1R activation at the endoplasmic reticulum, resulting in augmented Ca(2+) release and amplified depolarization due to subsequent stimulation of TRPC.	Cocaine	45-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	119-123
26078455-4	2015	These data indicate that oscillations elicited by IP3 uncaging are driven by the biphasic regulation of the IP3 receptor by Ca(2+), and, unlike hormone-dependent responses, do not require PLC.	Inositol 1,4,5-Trisphosphate	50-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	108-120
25921245-8	2015	In summary, IP3R-mediated ER Ca(2+) release promoted the elevations of [Ca(2+)]c and [Ca(2+)]mit in Pb-exposed rPT cells, which played a chief role in apoptosis induced by impaired calcium homeostasis.	Calcium	181-188	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	12-16
25847862-5	2015	MTT assay was used to assess the cytotoxic effects of curcumin on the lung cancer cells; the inositol 1,4,5-trisphosphate receptor (IP3R, a key regulator of [Ca2+]i signaling) was blocked by its specific inhibitor, xestospongin C (XSC).	monooxyethylene trimethylolpropane tristearate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	132-136
26005911-9	2015	In HCT116 and HT-29 cells, the alphaLA-induced [Ca(2+)]i increase was partially inhibited by pretreatment with EGTA, phospholipase C inhibitor edelfosine, cADPR inhibitors 8-bro-cADPR or DAB, and abolished by pretreatment with Ca(2+)ATPase inhibitor thapsigargin, but was not affected by Gi/o protein inhibitor PTX or IP3R inhibitor 2-APB.	alpha-Linolenic Acid	31-38	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	318-322
26005911-9	2015	In HCT116 and HT-29 cells, the alphaLA-induced [Ca(2+)]i increase was partially inhibited by pretreatment with EGTA, phospholipase C inhibitor edelfosine, cADPR inhibitors 8-bro-cADPR or DAB, and abolished by pretreatment with Ca(2+)ATPase inhibitor thapsigargin, but was not affected by Gi/o protein inhibitor PTX or IP3R inhibitor 2-APB.	Egtazic Acid	111-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	318-322
26311641-14	2015	(2) After treated with IP3 receptor antagonist, blocker of sarcoplasmic reticulum calcium-ATP, depleted agent of the ryanodine receptor-operated Ca(2+), the  F[Ca(2+)]i in both groups were significantly reduced (P &lt; 0.05), the increase in ADS group was significantly higher than that in the control (P &lt; 0.05).	calcium-atp	82-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	23-35
25796361-3	2015	ITPR3 is required for bicarbonate secretion by bile ducts, and its expression is reduced in intrahepatic bile ducts of patients with cholestatic disorders.	Bicarbonates	22-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-5
25796361-7	2015	ITPR3 activity was determined by measuring calcium signaling in normal human cholangiocyte cells and secretion in isolated bile duct units.	Calcium	43-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-5
25796361-13	2015	Knockdown of NRF2 with small interfering RNAs restored expression and function of ITPR3 in NHC cells incubated with quercetin.	Quercetin	116-125	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-87
25796361-15	2015	CONCLUSIONS: The transcription factor NRF2 binds to the promoter of ITPR3 to inhibit its expression in cholangiocytes, leading to reduced calcium signaling and bile duct secretion.	Calcium	138-145	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	68-73
26009185-4	2015	Adenophostin (AdA) is the most potent known agonist at the inositol 1,4,5-trisphosphate receptor (IP3R) and synthetic analogues provide a binding model for receptor activation and channel opening.	adenophostin A	0-12	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-102
26009185-5	2015	2-O-Modified inositol 1,4,5-trisphosphate (IP3) derivatives that are partial agonists at the IP3R reveal key conformational changes of the receptor upon ligand binding.	hippuric acid	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-97
26009185-5	2015	2-O-Modified inositol 1,4,5-trisphosphate (IP3) derivatives that are partial agonists at the IP3R reveal key conformational changes of the receptor upon ligand binding.	Inositol 1,4,5-Trisphosphate	13-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-97
26009185-5	2015	2-O-Modified inositol 1,4,5-trisphosphate (IP3) derivatives that are partial agonists at the IP3R reveal key conformational changes of the receptor upon ligand binding.	Inositol 1,4,5-Trisphosphate	43-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-97
26009185-6	2015	Biphenyl polyphosphates illustrate that simple non-inositol surrogates can be engineered to give prototype IP3R agonists or antagonists and act as templates for protein co-crystallization.	biphenyl polyphosphates	0-23	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-111
26009185-6	2015	Biphenyl polyphosphates illustrate that simple non-inositol surrogates can be engineered to give prototype IP3R agonists or antagonists and act as templates for protein co-crystallization.	Inositol	51-59	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-111
25847862-5	2015	MTT assay was used to assess the cytotoxic effects of curcumin on the lung cancer cells; the inositol 1,4,5-trisphosphate receptor (IP3R, a key regulator of [Ca2+]i signaling) was blocked by its specific inhibitor, xestospongin C (XSC).	xestospongin C	215-229	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	132-136
25847862-5	2015	MTT assay was used to assess the cytotoxic effects of curcumin on the lung cancer cells; the inositol 1,4,5-trisphosphate receptor (IP3R, a key regulator of [Ca2+]i signaling) was blocked by its specific inhibitor, xestospongin C (XSC).	xestospongin C	231-234	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	132-136
25847862-10	2015	Treatment with curcumin downregulated the expression of Bcl-2, and elevated the phosphorylation level of IP3R in a concentration-dependent manner.	Curcumin	15-23	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-109
25847862-12	2015	In conclusion, the cytotoxic effects of curcumin on lung cancer cells were induced by calcium overload, which involves Bcl-2 mediated IP3R phosphorylation.	Curcumin	40-48	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	134-138
25847862-12	2015	In conclusion, the cytotoxic effects of curcumin on lung cancer cells were induced by calcium overload, which involves Bcl-2 mediated IP3R phosphorylation.	Calcium	86-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	134-138
25650923-0	2015	Exact stochastic simulation of a calcium microdomain reveals the impact of Ca2+ fluctuations on IP3R gating.	Calcium	33-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-100
25765490-5	2015	Treatment with the IP3R antagonist heparin prevented mechanical allodynia with no effect on thermal response.	Heparin	35-42	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-23
24802256-9	2015	AA stimulated intracellular calcium release, which was attenuated by inositol 1,4,5-trisphosphate (IP3) receptor antagonists.	Calcium	28-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	99-112
24802256-9	2015	AA stimulated intracellular calcium release, which was attenuated by inositol 1,4,5-trisphosphate (IP3) receptor antagonists.	Inositol 1,4,5-Trisphosphate	69-97	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	99-112
25747709-9	2015	Hypoxia or GdCl3, an agonist of CaSR, increased the expression of BACE1 in hippocampal neurons and tissue, but Calhex 231 or Xesto C (a selective inhibitor of IP3 receptor) partly prevented hypoxia-induced BACE1 overexpression.	gadolinium chloride	11-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-171
25747709-9	2015	Hypoxia or GdCl3, an agonist of CaSR, increased the expression of BACE1 in hippocampal neurons and tissue, but Calhex 231 or Xesto C (a selective inhibitor of IP3 receptor) partly prevented hypoxia-induced BACE1 overexpression.	xesto c	125-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-171
25650923-7	2015	In a pure diffusion model the effects become apparent at elevated calcium concentrations, e.g., at [Ca(2+)] = 25 muM, tauac = 0.082 ms, the IP3R open probability increased by  20% and mean open times increased by  4 ms, compared to a zero noise model.	Calcium	66-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-144
25650923-7	2015	In a pure diffusion model the effects become apparent at elevated calcium concentrations, e.g., at [Ca(2+)] = 25 muM, tauac = 0.082 ms, the IP3R open probability increased by  20% and mean open times increased by  4 ms, compared to a zero noise model.	tauac	118-123	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-144
25650923-10	2015	These results suggest a functional role of local calcium noise properties on calcium-regulated target molecules such as the ubiquitous IP3R.	Calcium	49-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	135-139
25650923-10	2015	These results suggest a functional role of local calcium noise properties on calcium-regulated target molecules such as the ubiquitous IP3R.	Calcium	77-84	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	135-139
25442114-9	2015	Moreover, pharmacologic inhibition of endoplasmic reticulum (ER) inositol-1,4,5-triphosphate receptor (IP3R) and mitCa(2+) uniporter (MCU) evidenced that Abeta + NMDA-induced mitCa(2+) rise involves ER Ca(2+) release through IP3R and mitochondrial entry by the MCU.	N-Methylaspartate	162-166	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	103-107
25634048-3	2015	Inositol 1, 4, 5 trisphosphate (IP3) operates on IP3 receptor on the endoplasmic reticulum, and is related to a release of calcium in the cell.	Inositol 1,4,5-Trisphosphate	0-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-61
25634048-3	2015	Inositol 1, 4, 5 trisphosphate (IP3) operates on IP3 receptor on the endoplasmic reticulum, and is related to a release of calcium in the cell.	Inositol 1,4,5-Trisphosphate	32-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-61
25431134-8	2015	During prolonged stimulation with PTH(1-34), hyperactive cAMP signalling junctions, within which cAMP is delivered directly and at saturating concentrations to its targets, mediate sensitization of IP3R and a more slowly developing inhibition of IP3 accumulation.	Cyclic AMP	57-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-202
25431134-8	2015	During prolonged stimulation with PTH(1-34), hyperactive cAMP signalling junctions, within which cAMP is delivered directly and at saturating concentrations to its targets, mediate sensitization of IP3R and a more slowly developing inhibition of IP3 accumulation.	Cyclic AMP	97-101	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-202
25497594-1	2015	IP3 receptor (IP3R) was found to release Ca(2+) from non-mitochondrial store but the exact localization and the mode of action of IP3 remained a mystery.	Inositol 1,4,5-Trisphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	14-18
25569772-0	2015	Modulation of elementary calcium release mediates a transition from puffs to waves in an IP3R cluster model.	Calcium	25-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-93
25497594-8	2015	Moreover, IP3 was found not only to release Ca(2+), but also to release IRBIT (IP3receptor binding protein released with inositol trisphosphate) essential for the regulation of acid-base balance, RNA synthesis and ribonucleotide reductase.	Inositol 1,4,5-Trisphosphate	10-13	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-90
25497594-8	2015	Moreover, IP3 was found not only to release Ca(2+), but also to release IRBIT (IP3receptor binding protein released with inositol trisphosphate) essential for the regulation of acid-base balance, RNA synthesis and ribonucleotide reductase.	inositol 1,2,3-trisphosphate	121-143	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-90
25530524-4	2015	IP3 then binds to the IP3 receptor and mobilizes Ca2+ from endoplasmic reticulum Ca2+ stores, followed by Ca2+ influxes from the extracellular space.	Inositol 1,4,5-Trisphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-34
25399672-1	2014	Inositol 1,4,5-trisphosphate (IP3 ) is a universal signalling molecule that releases calcium from stores within cells by activating the IP3 receptor.	Inositol 1,4,5-Trisphosphate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-148
25704015-2	2015	Upon activation, the Sig-1R binds to the inositol trisphosphate receptor (IP3R), and modulates cellular calcium (Ca(2+)) homeostasis.	Calcium	104-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-78
25399672-1	2014	Inositol 1,4,5-trisphosphate (IP3 ) is a universal signalling molecule that releases calcium from stores within cells by activating the IP3 receptor.	Inositol 1,4,5-Trisphosphate	30-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-148
25399672-1	2014	Inositol 1,4,5-trisphosphate (IP3 ) is a universal signalling molecule that releases calcium from stores within cells by activating the IP3 receptor.	Calcium	85-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-148
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	6-carboxyfluorescein	88-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	9-13
24827904-9	2014	Ca(2+) flux assay and p-IP3R expression founded that homoharringtonine retained by the H1 R/CMC model increased phosphorylation of IP3R and promoted cytosolic free Ca(2+) elevation in a dose-dependent manner which further verified the activity of homoharringtonine in activating the H1 R.	Homoharringtonine	53-70	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	24-28
24827904-9	2014	Ca(2+) flux assay and p-IP3R expression founded that homoharringtonine retained by the H1 R/CMC model increased phosphorylation of IP3R and promoted cytosolic free Ca(2+) elevation in a dose-dependent manner which further verified the activity of homoharringtonine in activating the H1 R.	Homoharringtonine	53-70	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	131-135
25368151-1	2014	Calcium (Ca(2+)) is a secondary messenger in cells and Ca(2+) flux initiated from endoplasmic reticulum (ER) stores via inositol 1,4,5-triphosphate (IP3) binding to the IP3 receptor (IP3R) is particularly important for the activation and function of immune cells.	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	169-181
25368151-1	2014	Calcium (Ca(2+)) is a secondary messenger in cells and Ca(2+) flux initiated from endoplasmic reticulum (ER) stores via inositol 1,4,5-triphosphate (IP3) binding to the IP3 receptor (IP3R) is particularly important for the activation and function of immune cells.	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	183-187
25368151-1	2014	Calcium (Ca(2+)) is a secondary messenger in cells and Ca(2+) flux initiated from endoplasmic reticulum (ER) stores via inositol 1,4,5-triphosphate (IP3) binding to the IP3 receptor (IP3R) is particularly important for the activation and function of immune cells.	Inositol 1,4,5-Trisphosphate	120-147	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	169-181
25368151-1	2014	Calcium (Ca(2+)) is a secondary messenger in cells and Ca(2+) flux initiated from endoplasmic reticulum (ER) stores via inositol 1,4,5-triphosphate (IP3) binding to the IP3 receptor (IP3R) is particularly important for the activation and function of immune cells.	Inositol 1,4,5-Trisphosphate	120-147	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	183-187
25368151-1	2014	Calcium (Ca(2+)) is a secondary messenger in cells and Ca(2+) flux initiated from endoplasmic reticulum (ER) stores via inositol 1,4,5-triphosphate (IP3) binding to the IP3 receptor (IP3R) is particularly important for the activation and function of immune cells.	Inositol 1,4,5-Trisphosphate	149-152	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	169-181
25368151-1	2014	Calcium (Ca(2+)) is a secondary messenger in cells and Ca(2+) flux initiated from endoplasmic reticulum (ER) stores via inositol 1,4,5-triphosphate (IP3) binding to the IP3 receptor (IP3R) is particularly important for the activation and function of immune cells.	Inositol 1,4,5-Trisphosphate	149-152	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	183-187
25368151-3	2014	Here we show that Selk deficiency does not affect receptor-induced IP3 production, but Selk deficiency through genetic deletion or low selenium in culture media leads to low expression of the IP3R due to a defect in IP3R palmitoylation.	Selenium	135-143	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	192-196
25368151-7	2014	Mass spectrophotometric and bioinformatic analyses of the IP3R protein identified two palmitoylated cysteine residues and another potentially palmitoylated cysteine, and mutation of these three cysteines to alanines resulted in decreased IP3R palmitoylation and function.	Cysteine	100-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
25368151-7	2014	Mass spectrophotometric and bioinformatic analyses of the IP3R protein identified two palmitoylated cysteine residues and another potentially palmitoylated cysteine, and mutation of these three cysteines to alanines resulted in decreased IP3R palmitoylation and function.	Cysteine	156-164	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
25368151-7	2014	Mass spectrophotometric and bioinformatic analyses of the IP3R protein identified two palmitoylated cysteine residues and another potentially palmitoylated cysteine, and mutation of these three cysteines to alanines resulted in decreased IP3R palmitoylation and function.	Cysteine	194-203	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
25368151-7	2014	Mass spectrophotometric and bioinformatic analyses of the IP3R protein identified two palmitoylated cysteine residues and another potentially palmitoylated cysteine, and mutation of these three cysteines to alanines resulted in decreased IP3R palmitoylation and function.	Cysteine	194-203	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	238-242
25368151-7	2014	Mass spectrophotometric and bioinformatic analyses of the IP3R protein identified two palmitoylated cysteine residues and another potentially palmitoylated cysteine, and mutation of these three cysteines to alanines resulted in decreased IP3R palmitoylation and function.	Alanine	207-215	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
25368151-7	2014	Mass spectrophotometric and bioinformatic analyses of the IP3R protein identified two palmitoylated cysteine residues and another potentially palmitoylated cysteine, and mutation of these three cysteines to alanines resulted in decreased IP3R palmitoylation and function.	Alanine	207-215	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	238-242
24768714-8	2014	Bcl-2 at the ER acts via its N-terminal BH4 domain, which directly binds and inhibits the inositol 1,4,5-trisphosphate receptor (IP3R), the main intracellular Ca(2+)-release channel.	sapropterin	40-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-133
24768714-10	2014	The sensitivity of DLBCL cells to BH4-domain targeting tools strongly correlated with the expression levels of the IP3R2 channel, the IP3R isoform with the highest affinity for IP3.	sapropterin	34-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-119
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	6-carboxyfluorescein	88-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	6-carboxyfluorescein	88-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	6-carboxyfluorescein diacetate	110-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	9-13
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	6-carboxyfluorescein diacetate	110-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	6-carboxyfluorescein diacetate	110-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	ip3 ester	254-263	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	ip3 ester	254-263	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	Adenosine Triphosphate	267-270	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	Adenosine Triphosphate	267-270	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
25262337-7	2014	Likewise, 6-CFDA propagation through GJs was modulated by IP3R activation or inhibition in cell pairs of isolated adult cardiomyocytes.	6-carboxyfluorescein diacetate	10-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
25159857-4	2014	Very little, however, is known about their molecular architecture and therefore most critical issues surrounding gating of IP3R channels are still ambiguous, including the central question of how opening of the IP3R pore is initiated by IP3 and Ca(2+).	Inositol 1,4,5-Trisphosphate	123-126	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	211-215
25016315-1	2014	Calcium puffs are localized Ca(2+) signals mediated by Ca(2+) release from the endoplasmic reticulum (ER) through clusters of inositol trisphosphate receptor (IP3R) channels.	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-163
25149175-5	2014	Inhibition of the IP3 receptor (IP3R) with 2-aminoethoxydiphenyl borate (2-APB) also effectively blocked celastrol-induced mitochondrial Ca2+ accumulation and subsequent paraptotic events.	2-aminoethoxydiphenyl borate	43-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	18-30
25149175-5	2014	Inhibition of the IP3 receptor (IP3R) with 2-aminoethoxydiphenyl borate (2-APB) also effectively blocked celastrol-induced mitochondrial Ca2+ accumulation and subsequent paraptotic events.	2-aminoethoxydiphenyl borate	73-78	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	32-36
25149175-5	2014	Inhibition of the IP3 receptor (IP3R) with 2-aminoethoxydiphenyl borate (2-APB) also effectively blocked celastrol-induced mitochondrial Ca2+ accumulation and subsequent paraptotic events.	2-aminoethoxydiphenyl borate	43-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	32-36
25149175-5	2014	Inhibition of the IP3 receptor (IP3R) with 2-aminoethoxydiphenyl borate (2-APB) also effectively blocked celastrol-induced mitochondrial Ca2+ accumulation and subsequent paraptotic events.	celastrol	105-114	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	18-30
25149175-5	2014	Inhibition of the IP3 receptor (IP3R) with 2-aminoethoxydiphenyl borate (2-APB) also effectively blocked celastrol-induced mitochondrial Ca2+ accumulation and subsequent paraptotic events.	2-aminoethoxydiphenyl borate	73-78	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	18-30
25149175-5	2014	Inhibition of the IP3 receptor (IP3R) with 2-aminoethoxydiphenyl borate (2-APB) also effectively blocked celastrol-induced mitochondrial Ca2+ accumulation and subsequent paraptotic events.	celastrol	105-114	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	32-36
24747490-7	2014	Nevertheless, a phospholipase C (PLC) inhibitor and an inositol triphosphate (IP3) receptor antagonist considerably suppressed ugonin U-stimulated Ca(2+) mobilization and subsequent superoxide release.	Superoxides	182-192	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-91
25149175-6	2014	Collectively, our results show that the IP3R-mediated release of Ca2+ from the ER and its subsequent MCU-mediatedinflux into mitochondria critically contribute to celastrol-induced paraptosis in cancer cells.	celastrol	163-172	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-44
24789203-2	2014	The ICC generate pacemaking signals by membrane depolarizations associated with the release of intracellular calcium (Ca(2+)) in the endoplasmic reticulum (ER) through inositol-trisphosphate (IP3) receptors (IP3R) and uptake by mitochondria (MT).	Calcium	109-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	208-212
24628114-5	2014	KEY RESULTS: Functional analyses showed that heparin was a competitive antagonist of all IP3R subtypes with different affinities for each (IP3R3 &gt; IP3R1 &gt;= IP3R2).	Heparin	45-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-144
24896114-0	2014	Frequency and relative prevalence of calcium blips and puffs in a model of small IP3R clusters.	Calcium	37-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-85
24896114-1	2014	In this work, we model the local calcium release from clusters with a few inositol 1,4,5-trisphosphate receptor (IP3R) channels, focusing on the stochastic process in which an open channel either triggers other channels to open (as a puff) or fails to cause any channel to open (as a blip).	Calcium	33-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	113-117
24896114-5	2014	This result suggests that blips are not just lapses to trigger puffs, but they may also possess a biological function to contribute to the initiation of calcium waves by a preceding increase of basal [Ca(2+)] in cells that have small IP3R clusters.	Calcium	153-160	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	234-238
24269522-9	2014	DHA dilated resistance pulmonary arteries in a dose-dependent manner in hypoxic or normoxic solution, and the effects of DHA were abolished after pre-treatment with heparin (100 mug/ml), a 1,4,5-triphosphate (IP3) receptor (IP3R) inhibitor or iberiotoxin (100 nmol/L), a specific inhibitor of BKCa channel.	Docosahexaenoic Acids	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	209-222
24646566-4	2014	The key event in activation of fluid secretion is an increase in intracellular [Ca(2+)] ([Ca(2+)]i) triggered by IP3-induced release of Ca(2+) from ER via the IP3R.	Inositol 1,4,5-Trisphosphate	113-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-163
24104765-7	2014	While DR5-specific agonist induces calcium signaling mainly in the cilioplasm via ciliary CaV1.2, thrombin specifically induces cytosolic calcium signaling through the IP3 receptor.	Calcium	138-145	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	168-180
24809793-6	2014	Histamine"s regulation of collagen gel contraction was characterized by using specific histamine-receptor antagonists, an IP3 receptor antagonist and a PKC inhibitor.	Histamine	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-134
24269522-9	2014	DHA dilated resistance pulmonary arteries in a dose-dependent manner in hypoxic or normoxic solution, and the effects of DHA were abolished after pre-treatment with heparin (100 mug/ml), a 1,4,5-triphosphate (IP3) receptor (IP3R) inhibitor or iberiotoxin (100 nmol/L), a specific inhibitor of BKCa channel.	Docosahexaenoic Acids	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	224-228
24269522-9	2014	DHA dilated resistance pulmonary arteries in a dose-dependent manner in hypoxic or normoxic solution, and the effects of DHA were abolished after pre-treatment with heparin (100 mug/ml), a 1,4,5-triphosphate (IP3) receptor (IP3R) inhibitor or iberiotoxin (100 nmol/L), a specific inhibitor of BKCa channel.	Docosahexaenoic Acids	121-124	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	209-222
24269522-9	2014	DHA dilated resistance pulmonary arteries in a dose-dependent manner in hypoxic or normoxic solution, and the effects of DHA were abolished after pre-treatment with heparin (100 mug/ml), a 1,4,5-triphosphate (IP3) receptor (IP3R) inhibitor or iberiotoxin (100 nmol/L), a specific inhibitor of BKCa channel.	Docosahexaenoic Acids	121-124	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	224-228
24269522-9	2014	DHA dilated resistance pulmonary arteries in a dose-dependent manner in hypoxic or normoxic solution, and the effects of DHA were abolished after pre-treatment with heparin (100 mug/ml), a 1,4,5-triphosphate (IP3) receptor (IP3R) inhibitor or iberiotoxin (100 nmol/L), a specific inhibitor of BKCa channel.	Heparin	165-172	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	209-222
24269522-9	2014	DHA dilated resistance pulmonary arteries in a dose-dependent manner in hypoxic or normoxic solution, and the effects of DHA were abolished after pre-treatment with heparin (100 mug/ml), a 1,4,5-triphosphate (IP3) receptor (IP3R) inhibitor or iberiotoxin (100 nmol/L), a specific inhibitor of BKCa channel.	Heparin	165-172	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	224-228
24904548-10	2014	Reciprocal co-immunoprecipitation suggested that Gag and IP3R proximity is favored when the PTAP motif in Gag is intact.	1-(4-methylphenyl)propane-2-amine	92-96	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	57-61
24866019-5	2014	Inositol 1,4,5-trisphosphate (IP3), generated by PLCgamma1 in response to pressure, sensitized IP3 receptors (IP3Rs) to Ca(2+) influx mediated by the mechanosensitive TRPC6 channel, synergistically increasing IP3R-mediated Ca(2+) release to activate TRPM4 currents, leading to smooth muscle depolarization and constriction of isolated cerebral arteries.	Inositol 1,4,5-Trisphosphate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
24866019-5	2014	Inositol 1,4,5-trisphosphate (IP3), generated by PLCgamma1 in response to pressure, sensitized IP3 receptors (IP3Rs) to Ca(2+) influx mediated by the mechanosensitive TRPC6 channel, synergistically increasing IP3R-mediated Ca(2+) release to activate TRPM4 currents, leading to smooth muscle depolarization and constriction of isolated cerebral arteries.	Inositol 1,4,5-Trisphosphate	30-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
24557761-9	2014	These findings suggest that ethanol-induced [Ca(2+)]i release, mediated by stimulating IP3R-gated Ca(2+) channel, activates Rho/ROCK in Caco-2 cells, thereby contributing to ethanol-induced intestinal barrier dysfunction.	Ethanol	28-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	87-91
25009703-4	2014	cAMP-dependent protein kinase (A-kinase) inhibitor Rp-8-Br-cAMPS increased the CE-WIB801C-downregulated [Ca(2+)]i level in a dose dependent manner, and strongly inhibited CE-WIB801C-induced inositol 1, 4, 5-trisphosphate receptor (IP3R) phosphorylation.	Cyclic AMP	0-4	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	231-235
25009703-5	2014	These results suggest that the inhibition of [Ca(2+)]i mobilization by CE-WIB801C is resulted from the cAMP/A-kinase-dependent phosphorylation of IP3R.	Cyclic AMP	103-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	146-150
24786499-1	2014	The stochastic dynamics of the inositol-1,4,5-trisphosphate (IP3) receptor (IP3R) is key to understanding a wide range of observed calcium (Ca2+) signals.	Calcium	131-138	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-74
24786499-1	2014	The stochastic dynamics of the inositol-1,4,5-trisphosphate (IP3) receptor (IP3R) is key to understanding a wide range of observed calcium (Ca2+) signals.	Calcium	131-138	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-80
24569874-9	2014	We propose that, in addition to the canonical alpha,beta phosphatidylinositol 3-kinase to Akt pathway, insulin engages both RyR-mediated Ca(2+) release and IP3-receptor-mediated mitochondrial Ca(2+) uptake, and that these signals jointly stimulate glucose uptake.	Glucose	248-255	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-168
24776736-2	2014	IP3R-mediated Ca2+ signals involve Ca2+-induced Ca2+-release (CICR) whereby Ca2+ release through one open IP3R induces the opening of other channels.	cicr	62-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
24776736-2	2014	IP3R-mediated Ca2+ signals involve Ca2+-induced Ca2+-release (CICR) whereby Ca2+ release through one open IP3R induces the opening of other channels.	cicr	62-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	106-110
24557761-9	2014	These findings suggest that ethanol-induced [Ca(2+)]i release, mediated by stimulating IP3R-gated Ca(2+) channel, activates Rho/ROCK in Caco-2 cells, thereby contributing to ethanol-induced intestinal barrier dysfunction.	Ethanol	174-181	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	87-91
24586273-8	2014	hiPSC-derived neurons exhibited inositol tri-phosphate (IP3) receptor-dependent release of intracellular calcium from the endoplasmic reticulum in neuronal processes as calcium waves propagating from apical and distal dendrites, and in the soma.	triphosphoric acid	41-54	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-69
24586273-8	2014	hiPSC-derived neurons exhibited inositol tri-phosphate (IP3) receptor-dependent release of intracellular calcium from the endoplasmic reticulum in neuronal processes as calcium waves propagating from apical and distal dendrites, and in the soma.	Calcium	105-112	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-69
24586273-8	2014	hiPSC-derived neurons exhibited inositol tri-phosphate (IP3) receptor-dependent release of intracellular calcium from the endoplasmic reticulum in neuronal processes as calcium waves propagating from apical and distal dendrites, and in the soma.	Calcium	169-176	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-69
24450629-3	2014	High-resolution structures of the N-terminal region of the IP3R (IP3 receptor) have established that the two essential phosphate groups of IP3 bind to opposite sides of the IP3-binding site, pulling its two domains together.	Phosphates	119-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	59-63
24450629-3	2014	High-resolution structures of the N-terminal region of the IP3R (IP3 receptor) have established that the two essential phosphate groups of IP3 bind to opposite sides of the IP3-binding site, pulling its two domains together.	Phosphates	119-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-77
24450629-3	2014	High-resolution structures of the N-terminal region of the IP3R (IP3 receptor) have established that the two essential phosphate groups of IP3 bind to opposite sides of the IP3-binding site, pulling its two domains together.	Inositol 1,4,5-Trisphosphate	59-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-77
24450629-3	2014	High-resolution structures of the N-terminal region of the IP3R (IP3 receptor) have established that the two essential phosphate groups of IP3 bind to opposite sides of the IP3-binding site, pulling its two domains together.	Inositol 1,4,5-Trisphosphate	65-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	59-63
23848206-9	2013	The effects of xanthochymol were enhanced by U0126, at low doses, and were blocked by heparin, indicating that the MEK pathway is involved, while the ER IP3 receptor is critical for its action.	xanthochymol	15-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	153-165
23939423-9	2013	The ER IP3 receptor antagonist heparin blocked this release, indicating that the receptor is required for activity.	Heparin	31-38	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	7-19
23582047-4	2013	Concurrently, cytosolic calcium increased and reticular calcium was depleted in concentration-dependent manner, partially by the involvement of IP3 R.	Calcium	24-31	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	144-149
24323417-10	2013	New studies reveal that DHA blocks inositol trisphosphate receptor (IP3R)-mediated ER Ca(2+) depletion and ER stress.	Docosahexaenoic Acids	24-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	68-72
23838008-7	2013	Pertussis toxin (a specific inhibitor of Gi/o proteins), edelfosine (an inhibitor of phospholipase C), or 2-APB (an inhibitor of IP3 receptor) completely inhibited LPE-induced [Ca(2+)]i increases, whereas HA130, an inhibitor of autotaxin/lysophospholipase D, did not.	2-aminoethoxydiphenyl borate	106-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-141
23838008-7	2013	Pertussis toxin (a specific inhibitor of Gi/o proteins), edelfosine (an inhibitor of phospholipase C), or 2-APB (an inhibitor of IP3 receptor) completely inhibited LPE-induced [Ca(2+)]i increases, whereas HA130, an inhibitor of autotaxin/lysophospholipase D, did not.	lysophosphatidylethanolamine	164-167	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-141
23992640-9	2013	Indeed, ATP increased MCF-7 cell proliferation and this effect was impaired when the expression of BKCa and/or IP3R3 has been reduced by specific small interfering RNAs (siRNAs).	Adenosine Triphosphate	8-11	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-116
23992640-12	2013	Furthermore, ATP elicited a phospholipase C (PLC)-dependent elevation of internal Ca(2+) that triggered in turn an iberiotoxin (IbTx)- and a tetra-ethyl-ammonium (TEA)-sensitive membrane hyperpolarisation that was strongly reduced in the cells with silenced IP3R3 or BKCa.	Adenosine Triphosphate	13-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	258-263
23992640-12	2013	Furthermore, ATP elicited a phospholipase C (PLC)-dependent elevation of internal Ca(2+) that triggered in turn an iberiotoxin (IbTx)- and a tetra-ethyl-ammonium (TEA)-sensitive membrane hyperpolarisation that was strongly reduced in the cells with silenced IP3R3 or BKCa.	iberiotoxin	115-126	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	258-263
23992640-12	2013	Furthermore, ATP elicited a phospholipase C (PLC)-dependent elevation of internal Ca(2+) that triggered in turn an iberiotoxin (IbTx)- and a tetra-ethyl-ammonium (TEA)-sensitive membrane hyperpolarisation that was strongly reduced in the cells with silenced IP3R3 or BKCa.	iberiotoxin	128-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	258-263
23992640-15	2013	BKCa and IP3R3 also co-immunoprecipitated and this interaction seemed to occur in cholesterol-enriched microdomains.	Cholesterol	82-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	9-14
24086047-6	2013	Understanding how Ca(2+) effectively and specifically regulates so many cellular processes demands an understanding of the interplay between IP3 and Ca(2+) in controlling IP3R gating.	Inositol 1,4,5-Trisphosphate	141-144	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	171-175
24086050-2	2013	This protocol describes an FP assay for the binding of fluorescein-labeled inositol 1,4,5-trisphosphate (IP3) to amino-terminal fragments of the IP3 receptor at different temperatures and in the presence of competing ligands.	Fluorescein	55-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	145-157
24086050-2	2013	This protocol describes an FP assay for the binding of fluorescein-labeled inositol 1,4,5-trisphosphate (IP3) to amino-terminal fragments of the IP3 receptor at different temperatures and in the presence of competing ligands.	Inositol 1,4,5-Trisphosphate	75-103	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	145-157
24086050-2	2013	This protocol describes an FP assay for the binding of fluorescein-labeled inositol 1,4,5-trisphosphate (IP3) to amino-terminal fragments of the IP3 receptor at different temperatures and in the presence of competing ligands.	Inositol 1,4,5-Trisphosphate	105-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	145-157
23582047-4	2013	Concurrently, cytosolic calcium increased and reticular calcium was depleted in concentration-dependent manner, partially by the involvement of IP3 R.	Calcium	56-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	144-149
23653093-1	2013	The influence of stochastic inositol-1,4,5-trisphosphate receptor (IP3R) dynamics and their clustering have been extensively investigated to explore the mechanism through which the stochastic molecular event finally shape the intracellular calcium signaling.	Calcium	240-247	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	67-71
23653093-4	2013	In this work, we include both the IP3R dynamics and the typical agonist induced signaling transduction cascade in the model to investigate the essential influence of stochastic IP3R dynamics on the coding of the stimulus induced calcium signal.	Calcium	229-236	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	34-38
23653093-4	2013	In this work, we include both the IP3R dynamics and the typical agonist induced signaling transduction cascade in the model to investigate the essential influence of stochastic IP3R dynamics on the coding of the stimulus induced calcium signal.	Calcium	229-236	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	177-181
23380704-5	2013	The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) and IP3-induced Ca(2+) signaling are important players in these processes.	Inositol 1,4,5-Trisphosphate	34-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
23704996-9	2013	We found that PIP2 and adenophostin, a potent IP3-receptor agonist, rescued MARCKS inhibition in permeabilized sperm, suggesting that MARCKS inhibits acrosomal exocytosis by sequestering PIP2 and, indirectly, MARCKS regulates the intracellular calcium mobilization.	Phosphatidylinositol 4,5-Diphosphate	14-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-58
23602525-1	2013	2-Aminoethyl diphenylborinate (2-APB) is a known modulator of the IP3 receptor, the calcium ATPase SERCA, the calcium release-activated calcium channel Orai and TRP channels.	2-aminoethyl diphenylborinate	0-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	66-78
23615449-7	2013	This is accompanied by IL-1beta-induced apoptosis, which is prevented by JNK1/2 siRNA and the IP3R inhibitor xestospongin C.	xestospongin C	109-123	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	94-98
23704996-9	2013	We found that PIP2 and adenophostin, a potent IP3-receptor agonist, rescued MARCKS inhibition in permeabilized sperm, suggesting that MARCKS inhibits acrosomal exocytosis by sequestering PIP2 and, indirectly, MARCKS regulates the intracellular calcium mobilization.	adenophostin A	23-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-58
23525004-1	2013	Cholesterol depletion reversibly abolishes carbachol-evoked Ca(2+) release from inositol (1,4,5)-trisphosphate (IP3)-sensitive stores, without affecting the distribution of IP3 receptors (IP3R) or endoplasmic reticulum, IP3 formation or responses to photolysis of caged IP3.	Carbachol	43-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	188-192
23525004-4	2013	We suggest that muscarinic acetylcholine receptors in lipid rafts deliver IP3 at high concentration to associated IP3R, stimulating them to release Ca(2+).	Inositol 1,4,5-Trisphosphate	74-77	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	114-118
23525004-1	2013	Cholesterol depletion reversibly abolishes carbachol-evoked Ca(2+) release from inositol (1,4,5)-trisphosphate (IP3)-sensitive stores, without affecting the distribution of IP3 receptors (IP3R) or endoplasmic reticulum, IP3 formation or responses to photolysis of caged IP3.	Cholesterol	0-11	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	188-192
23525004-6	2013	These IP3R, probably type 2 IP3R within a discrete Ca(2+) store, are activated only when their sensitivity is increased by cAMP.	Cyclic AMP	123-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	6-10
23525004-6	2013	These IP3R, probably type 2 IP3R within a discrete Ca(2+) store, are activated only when their sensitivity is increased by cAMP.	Cyclic AMP	123-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-32
23525004-7	2013	Sensitization of IP3R by cAMP extends the effective range of signalling by phospholipase C, allowing muscarinic receptors that are otherwise ineffective to recruit additional IP3-sensitive Ca(2+) stores.	Cyclic AMP	25-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	17-21
23282150-1	2013	IP(3)R (IP(3) [inositol 1,4,5-trisphosphate] receptors) and ryanodine receptors are the most widely expressed intracellular Ca(2+) channels and both are regulated by thiol reagents.	Sulfhydryl Compounds	166-171	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-6
23614408-4	2013	Here we test the validity of the latter modeling approach by using two different models to calculate the frequency of localized calcium signals (calcium puffs) from clustered IP3 receptor channels.	Calcium	128-135	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	175-187
23395717-1	2013	Xestospongin C (XC), which is a group of macrocyclic bis-1-oxaquinolizidines, is a potent inhibitor of sarcoendoplasmic reticulum calcium transport ATPase and IP3 receptor.	xestospongin C	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-171
23395717-1	2013	Xestospongin C (XC), which is a group of macrocyclic bis-1-oxaquinolizidines, is a potent inhibitor of sarcoendoplasmic reticulum calcium transport ATPase and IP3 receptor.	xestospongin C	16-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-171
23395717-1	2013	Xestospongin C (XC), which is a group of macrocyclic bis-1-oxaquinolizidines, is a potent inhibitor of sarcoendoplasmic reticulum calcium transport ATPase and IP3 receptor.	bis-1-oxaquinolizidines	53-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-171
23282150-2	2013	In DT40 cells stably expressing single subtypes of mammalian IP(3)R, low concentrations of thimerosal (also known as thiomersal), which oxidizes thiols to form a thiomercurylethyl complex, increased the sensitivity of IP(3)-evoked Ca(2+) release via IP(3)R1 and IP(3)R2, but inhibited IP(3)R3.	Thimerosal	91-101	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-67
23282150-2	2013	In DT40 cells stably expressing single subtypes of mammalian IP(3)R, low concentrations of thimerosal (also known as thiomersal), which oxidizes thiols to form a thiomercurylethyl complex, increased the sensitivity of IP(3)-evoked Ca(2+) release via IP(3)R1 and IP(3)R2, but inhibited IP(3)R3.	Thimerosal	91-101	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	285-292
23282150-2	2013	In DT40 cells stably expressing single subtypes of mammalian IP(3)R, low concentrations of thimerosal (also known as thiomersal), which oxidizes thiols to form a thiomercurylethyl complex, increased the sensitivity of IP(3)-evoked Ca(2+) release via IP(3)R1 and IP(3)R2, but inhibited IP(3)R3.	Sulfhydryl Compounds	145-151	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-67
23282150-8	2013	Chimaeric proteins in which the SD of the IP(3)R was replaced by the structurally related A domain of a ryanodine receptor were functional, but thimerosal inhibited both IP(3) binding to the chimaeric NT and IP(3)-evoked Ca(2+) release from the chimaeric IP(3)R.	Thimerosal	144-154	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	255-261
23282150-9	2013	This is the first systematic analysis of the effects of a thiol reagent on each IP(3)R subtype.	Sulfhydryl Compounds	58-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-86
22955373-9	2013	Thus, IP3R-derived molecules that mimic the BH4 domain"s binding site on the IP3R may function synergistically with BH3-mimetic molecules selectivity suppressing Bcl-2"s proto-oncogenic activity.	sapropterin	44-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	6-10
23630568-12	2013	We conclude that the kinetics of IP3R with different concentrations of Ca(2+) and IP3 should be more carefully addressed when new models for IP3R are developed.	Inositol 1,4,5-Trisphosphate	33-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
22955373-9	2013	Thus, IP3R-derived molecules that mimic the BH4 domain"s binding site on the IP3R may function synergistically with BH3-mimetic molecules selectivity suppressing Bcl-2"s proto-oncogenic activity.	sapropterin	44-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	77-81
22955373-9	2013	Thus, IP3R-derived molecules that mimic the BH4 domain"s binding site on the IP3R may function synergistically with BH3-mimetic molecules selectivity suppressing Bcl-2"s proto-oncogenic activity.	BH 3	116-119	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	6-10
22955373-9	2013	Thus, IP3R-derived molecules that mimic the BH4 domain"s binding site on the IP3R may function synergistically with BH3-mimetic molecules selectivity suppressing Bcl-2"s proto-oncogenic activity.	BH 3	116-119	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	77-81
23228564-10	2013	Finally, in MEG 01 incubated with FK506 we observed a reduction in TRPC1/FKBP52 coupling, and similarly, FKBP52 silencing reduced the association between IP3R type II and TRPC1 during SOCE.	Tacrolimus	34-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	154-158
23122229-5	2013	Designed sensor comprising the IP(3)-binding core domain of IP(3)-receptor fused between complementary non-functional fragments of firefly luciferase allows direct detection of IP(3) in presence of luciferin substrate both in cell lysate and in living cells.	Inositol 1,4,5-Trisphosphate	31-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-74
23122229-5	2013	Designed sensor comprising the IP(3)-binding core domain of IP(3)-receptor fused between complementary non-functional fragments of firefly luciferase allows direct detection of IP(3) in presence of luciferin substrate both in cell lysate and in living cells.	D-luciferin	198-207	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-74
23469136-0	2013	Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues.	adenophostin A	71-85	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-58
23121601-6	2013	Pre-treatment of CGN cultures with an inhibitor (2-APB) of the inositol-triphosphate receptor (IP(3) R), which regulates Ca(2+) release from the endoplasmic reticulum (ER), blocked both the alcohol-induced rise in [Ca(2+)](i) and the neuronal death caused by alcohol.	2-aminoethoxydiphenyl borate	49-54	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	95-102
23121601-6	2013	Pre-treatment of CGN cultures with an inhibitor (2-APB) of the inositol-triphosphate receptor (IP(3) R), which regulates Ca(2+) release from the endoplasmic reticulum (ER), blocked both the alcohol-induced rise in [Ca(2+)](i) and the neuronal death caused by alcohol.	Alcohols	190-197	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	95-102
23121601-6	2013	Pre-treatment of CGN cultures with an inhibitor (2-APB) of the inositol-triphosphate receptor (IP(3) R), which regulates Ca(2+) release from the endoplasmic reticulum (ER), blocked both the alcohol-induced rise in [Ca(2+)](i) and the neuronal death caused by alcohol.	Alcohols	259-266	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	95-102
23122728-1	2013	An important role in the regulation of apoptotic calcium release is played by the ubiquitously expressed family of inositol 1,4,5-trisphosphate receptor (IP(3)R) channels.	Calcium	49-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	154-160
23122728-7	2013	Significantly, blocking IP(3) binding to the IP(3)R with an IP(3) sponge resulted in suppression of staurosporine-induced calcium release and cell death.	Staurosporine	100-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-51
23122728-7	2013	Significantly, blocking IP(3) binding to the IP(3)R with an IP(3) sponge resulted in suppression of staurosporine-induced calcium release and cell death.	Calcium	122-129	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-51
23305836-2	2013	Two distinct classes of Ca(2+) release channels, which mobilize Ca(2+) from the store, exist; the inositol 1,4,5-trisphosphate (IP(3)) receptor and the ryanodine receptor.	Inositol 1,4,5-Trisphosphate	98-126	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	128-143
23469136-4	2013	The two essential phosphate groups contribute to closure of the clam-like IP3-binding core (IBC), and thereby IP3R activation, by binding to each of its sides (the alpha- and beta-domains).	Phosphates	18-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
23469136-4	2013	The two essential phosphate groups contribute to closure of the clam-like IP3-binding core (IBC), and thereby IP3R activation, by binding to each of its sides (the alpha- and beta-domains).	Inositol 1,4,5-Trisphosphate	74-77	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
23469136-3	2013	Adenophostin A (AdA) is the most potent naturally occurring agonist of IP3R and it shares with IP3 the essential features of all IP3R agonists, namely structures equivalent to the 4,5-bisphosphate and 6-hydroxyl of IP3.	adenophostin A	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-75
23469136-4	2013	The two essential phosphate groups contribute to closure of the clam-like IP3-binding core (IBC), and thereby IP3R activation, by binding to each of its sides (the alpha- and beta-domains).	Bucrylate	92-95	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
23469136-3	2013	Adenophostin A (AdA) is the most potent naturally occurring agonist of IP3R and it shares with IP3 the essential features of all IP3R agonists, namely structures equivalent to the 4,5-bisphosphate and 6-hydroxyl of IP3.	adenophostin A	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-133
22033379-4	2012	How does IP3 binding to the IP3-binding core in each IP3R subunit cause opening of a cation-selective pore formed by residues towards the C-terminal?	Inositol 1,4,5-Trisphosphate	9-12	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	53-57
23469136-9	2013	The two complementary contacts between AdA and the alpha-domain (cation-pi interaction and 3""-phosphate) allow activation of IP3R by an analogue of AdA (3""-dephospho-AdA) that lacks a phosphate group equivalent to the essential 5-phosphate of IP3.	3""-phosphate	91-104	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-130
23469136-9	2013	The two complementary contacts between AdA and the alpha-domain (cation-pi interaction and 3""-phosphate) allow activation of IP3R by an analogue of AdA (3""-dephospho-AdA) that lacks a phosphate group equivalent to the essential 5-phosphate of IP3.	Phosphates	95-104	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-130
23469136-9	2013	The two complementary contacts between AdA and the alpha-domain (cation-pi interaction and 3""-phosphate) allow activation of IP3R by an analogue of AdA (3""-dephospho-AdA) that lacks a phosphate group equivalent to the essential 5-phosphate of IP3.	5-phosphate	230-241	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-130
23372785-7	2013	Most analogues of IP(3) interact similarly with the three IP(3)R subtypes, but the decrease in potency accompanying removal of the 1-phosphate from (1,4,5)IP(3) was least for IP(3)R3.	sphingosine 1-phosphate	131-142	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	175-182
23022152-6	2012	All these alterations were prevented by the inhibitors of the IP3R and RyR receptors, 2-Aminoethoxydiphenyl borate (2-APB) and dantrolene.	2-aminoethoxydiphenyl borate	116-121	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-66
23022152-8	2012	CONCLUSIONS: In Caco-2 cells, INDO stimulates ER Ca(2+) mobilization, probably through the activation of IP3R and RyR receptors, and the subsequent entry of Ca(2+) into the mitochondria.	Indomethacin	30-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-109
23086950-1	2012	We have combined alanine mutagenesis and functional assays to identify amino acid residues in the channel domain that are critical for inositol 1,4,5-trisphosphate receptor (IP(3)R) channel function.	Alanine	17-24	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	174-180
22713857-10	2012	We extend the original eight-state model to a 12-state model in order to illustrate this competition, and perform a similar reduction to that of Li and Rinzel in the first modeling study we are aware of considering PA effect on an IP(3) receptor.	Protactinium	215-217	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	231-245
23650607-3	2012	Two-consecutive phenylalanine residues (Phe185/Phe186) in Tespa1, which are conserved between Tespa1 and KRAP, are indispensable for the association between Tespa1 and IP3R.	Phenylalanine	16-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	168-172
22947927-2	2012	The model aims to represent accurately the kinetics of both receptor types of IP(3)R depending on the concentrations of inositol trisphosphate (IP(3)), adenosine trisphosphate (ATP), and intracellular calcium (Ca(2+)).	inositol 1,2,3-trisphosphate	120-142	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-84
22947927-2	2012	The model aims to represent accurately the kinetics of both receptor types of IP(3)R depending on the concentrations of inositol trisphosphate (IP(3)), adenosine trisphosphate (ATP), and intracellular calcium (Ca(2+)).	adenosine trisphosphate	152-175	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-84
22947927-2	2012	The model aims to represent accurately the kinetics of both receptor types of IP(3)R depending on the concentrations of inositol trisphosphate (IP(3)), adenosine trisphosphate (ATP), and intracellular calcium (Ca(2+)).	Adenosine Triphosphate	177-180	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-84
22947927-2	2012	The model aims to represent accurately the kinetics of both receptor types of IP(3)R depending on the concentrations of inositol trisphosphate (IP(3)), adenosine trisphosphate (ATP), and intracellular calcium (Ca(2+)).	Calcium	201-208	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-84
22033379-4	2012	How does IP3 binding to the IP3-binding core in each IP3R subunit cause opening of a cation-selective pore formed by residues towards the C-terminal?	Inositol 1,4,5-Trisphosphate	28-31	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	53-57
22033379-9	2012	The elementary Ca2+ release events evoked by IP3 in intact cells are mediated by very small numbers of active IP3R and the Ca2+-mediated interactions between them.	Inositol 1,4,5-Trisphosphate	45-48	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
22484014-3	2012	The release of neurotransmitters induced by K(+)-evoked stimulation was inhibited by perfusion with LEV in a concentration-dependent manner, and those induced by agonists of RyR and IP3R were also inhibited by LEV.	Levetiracetam	210-213	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	182-186
22695135-5	2012	Blockade of IP3R phosphorylation by the serine/threonine protein kinase Akt inhibitor wortmannin rescued calcium signaling.	Calcium	105-112	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	12-16
22695135-4	2012	We found that arsenic inhibited inositol trisphosphate receptor (IP3R) function in the endoplasmic reticulum by inducing phosphorylation, which led to decreased intracellular calcium levels.	Arsenic	14-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-69
22695135-4	2012	We found that arsenic inhibited inositol trisphosphate receptor (IP3R) function in the endoplasmic reticulum by inducing phosphorylation, which led to decreased intracellular calcium levels.	Calcium	175-182	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-69
22695135-5	2012	Blockade of IP3R phosphorylation by the serine/threonine protein kinase Akt inhibitor wortmannin rescued calcium signaling.	Wortmannin	86-96	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	12-16
22654111-4	2012	A combination of pharmacological and genetic tools demonstrated that the effect of elevated CO(2) on cAMP levels required the activity of the IP(3) receptor.	Carbon Dioxide	92-97	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	142-156
22654111-4	2012	A combination of pharmacological and genetic tools demonstrated that the effect of elevated CO(2) on cAMP levels required the activity of the IP(3) receptor.	Cyclic AMP	101-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	142-156
22654111-7	2012	Consistent with the cellular biochemistry, elevated CO(2) abrogated the inhibitory effect of cAMP on NHE3 function via an IP(3) receptor-dependent mechanism.	Carbon Dioxide	52-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-136
22654111-7	2012	Consistent with the cellular biochemistry, elevated CO(2) abrogated the inhibitory effect of cAMP on NHE3 function via an IP(3) receptor-dependent mechanism.	Cyclic AMP	93-97	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-136
22484014-4	2012	Specifically, the RyR-induced release was inhibited by 10 muM LEV, whereas the IP3R-induced release was inhibited by 100 muM LEV, but not by 10 or 30 muM LEV.	Levetiracetam	125-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-83
22484014-4	2012	Specifically, the RyR-induced release was inhibited by 10 muM LEV, whereas the IP3R-induced release was inhibited by 100 muM LEV, but not by 10 or 30 muM LEV.	Levetiracetam	125-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-83
22623752-2	2012	A fundamental question--how IP3 gates the Ca2+ channel within the IP3 receptor--remains unanswered.	Inositol 1,4,5-Trisphosphate	28-31	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	66-78
22465185-6	2012	100 muM PB212 induced a Ca(2+)-efflux from the endoplasmic reticulum through the inositol (1, 4, 5)-trisphosphate (IP(3)) receptor.	PB212	8-13	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-130
22465185-6	2012	100 muM PB212 induced a Ca(2+)-efflux from the endoplasmic reticulum through the inositol (1, 4, 5)-trisphosphate (IP(3)) receptor.	Inositol 1,4,5-Trisphosphate	81-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-130
22607572-10	2012	(iii) When the inositol triphosphate receptor (IP3R) calcium channel was blocked by 2-aminoethoxydiphenyl-borinate (2-APB), caspase-9 was completely inhibited, GRP78 and caspase-4 increased dramatically, and caspase-3 expression was not affected.	2-aminoethoxydiphenyl-borinate	84-114	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	47-51
22367186-4	2012	Here, we downregulated TRPC1 in CNE2 cells by RNAi             technology and by using 2-APB, an inhibitor of the inositol 1,4,5-trisphosphate             (IP3) receptor and of store-operated Ca2+ channel-mediated Ca2+ entry.	2-aminoethoxydiphenyl borate	87-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-169
22503562-2	2012	Here, we show that a calcium-sensing enzyme, CaMKII, is activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary hepatocytes and by glucagon and fasting in vivo.	Calcium	21-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	84-88
22503562-2	2012	Here, we show that a calcium-sensing enzyme, CaMKII, is activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary hepatocytes and by glucagon and fasting in vivo.	Cyclic AMP	109-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	84-88
22503562-2	2012	Here, we show that a calcium-sensing enzyme, CaMKII, is activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary hepatocytes and by glucagon and fasting in vivo.	Glucagon	118-126	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	84-88
22503562-2	2012	Here, we show that a calcium-sensing enzyme, CaMKII, is activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary hepatocytes and by glucagon and fasting in vivo.	Glucagon	157-165	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	84-88
22693433-12	2012	Thus our analysis hints at an additional role of IP3 and shows how cells can make use of the full complexity in IP3R gating behavior to achieve different signals.	Inositol 1,4,5-Trisphosphate	49-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-116
22552281-5	2012	Here, we show that Akt activation in COS7 cells, which lack of IP3R I, strongly suppresses IP3-mediated Ca2+ release and apoptosis.	cos7	37-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
22146309-5	2012	Blocking PLC and the downstream cascades with PLC inhibitor, IP(3) receptor antagonist, Ca(2+) chelator, and protein kinase C (PKC) inhibitors prevented the actions of corticosterone.	Corticosterone	168-182	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-75
22331871-3	2012	Here, we show that CB(2)Rs are located intracellularly in layer II/III pyramidal cells of the rodent medial prefrontal cortex (mPFC) and that their activation results in IP(3)R-dependent opening of Ca(2+)-activated Cl(-) channels.	cb(2)rs	19-26	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	170-176
22244921-3	2012	Pretreatment with U-73122 (a specific PLC inhibitor) or 2-APB (a specific IP3 receptor antagonist) attenuated this effect, suggesting that PLC/IP3 signaling cascade is involved in arsenite-induced elevation of [Ca2+]i. Cytotoxic concentrations of arsenite (5 and 10 muM) significantly enhanced endothelial nitric oxide synthase (eNOS) phosphorylation, nitric oxide (NO) production and apoptosis after 24-h exposure.	2-aminoethoxydiphenyl borate	56-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-86
22244921-3	2012	Pretreatment with U-73122 (a specific PLC inhibitor) or 2-APB (a specific IP3 receptor antagonist) attenuated this effect, suggesting that PLC/IP3 signaling cascade is involved in arsenite-induced elevation of [Ca2+]i. Cytotoxic concentrations of arsenite (5 and 10 muM) significantly enhanced endothelial nitric oxide synthase (eNOS) phosphorylation, nitric oxide (NO) production and apoptosis after 24-h exposure.	arsenite	180-188	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-86
22153976-9	2012	When a higher concentration (10mM) of BAPTA was included in the pipette solution, TICC activity was disrupted, suggesting that TRPM4 channels on the plasma membrane and IP(3)R on the SR are closely opposed but not physically coupled, and that endogenous Ca(2+) buffer proteins play a critical role in maintaining TRPM4 channel activity in native cerebral artery smooth muscle cells.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	38-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	169-175
21818117-5	2012	Changing Lys17 into Asp in BH4-Bcl-2 completely abolished its IP(3)R-binding and -inhibitory properties, whereas changing Asp11 into Lys in BH4-Bcl-Xl induced IP(3)R binding and inhibition.	sapropterin	140-143	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-165
21818117-9	2012	In agreement with the IP(3)R-binding properties, the antiapoptotic activity of BH4-Bcl-2 and BH4-Bcl-Xl was modulated by the Lys/Asp substitutions.	sapropterin	79-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-28
21818117-9	2012	In agreement with the IP(3)R-binding properties, the antiapoptotic activity of BH4-Bcl-2 and BH4-Bcl-Xl was modulated by the Lys/Asp substitutions.	Lysine	125-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-28
21818117-9	2012	In agreement with the IP(3)R-binding properties, the antiapoptotic activity of BH4-Bcl-2 and BH4-Bcl-Xl was modulated by the Lys/Asp substitutions.	Aspartic Acid	129-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-28
22209849-6	2012	Using an endoplasmic reticulum (ER)-Ca(2+) mobilizer (thapsigargin) and an ER-IP3R antagonist (heparin), results revealed ER as a major source of [Ca(2+)](c) which led to the activation of calpain and caspase12, and cleavage of fodrin.	Heparin	95-102	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-82
22185692-1	2012	The unique endoplasmic reticulum (ER) subdomain termed the mitochondria-associated ER membrane (MAM) engages the physical connection between the ER and the mitochondrial outer membrane and plays a role in regulating IP(3) receptor-mediated Ca(2+) influx and the phospholipid transport between the two organelles.	Phospholipids	262-274	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	216-230
21818117-0	2012	Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.	sapropterin	82-85	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	24-36
21818117-1	2012	Antiapoptotic B-cell lymphoma 2 (Bcl-2) targets the inositol 1,4,5-trisphosphate receptor (IP(3)R) via its BH4 domain, thereby suppressing IP(3)R Ca(2+)-flux properties and protecting against Ca(2+)-dependent apoptosis.	sapropterin	107-110	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	91-97
21818117-1	2012	Antiapoptotic B-cell lymphoma 2 (Bcl-2) targets the inositol 1,4,5-trisphosphate receptor (IP(3)R) via its BH4 domain, thereby suppressing IP(3)R Ca(2+)-flux properties and protecting against Ca(2+)-dependent apoptosis.	sapropterin	107-110	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-145
21818117-2	2012	Here, we directly compared IP(3)R inhibition by BH4-Bcl-2 and BH4-Bcl-Xl.	sapropterin	48-51	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	27-33
21818117-2	2012	Here, we directly compared IP(3)R inhibition by BH4-Bcl-2 and BH4-Bcl-Xl.	sapropterin	62-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	27-33
21818117-5	2012	Changing Lys17 into Asp in BH4-Bcl-2 completely abolished its IP(3)R-binding and -inhibitory properties, whereas changing Asp11 into Lys in BH4-Bcl-Xl induced IP(3)R binding and inhibition.	sapropterin	27-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-68
22453946-4	2012	The IP3R has an affinity for IP(3) in the low nanomolar range.	Inositol 1,4,5-Trisphosphate	29-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-8
22374086-1	2012	The Ca(2)                         (+) signals evoked by inositol 1,4,5-trisphosphate (IP(3)) are built from elementary Ca(2)                         (+) release events involving progressive recruitment of IP(3) receptors (IP(3)R), intracellular Ca(2)                         (+) channels that are expressed in almost all animal cells.	Inositol 1,4,5-Trisphosphate	56-84	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	205-228
22078634-6	2012	Both xestospongin C, a specific inhibitor of inositol 1,4,5-triphosphate receptors (IP(3)R), and ryanodine or ruthenium red, inhibitors of RyR, partially blocked LTD4-induced Ca(2+) oscillations.	xestospongin C	5-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	84-90
22078634-7	2012	Ca(2+) oscillations were almost completely inhibited by 50 muM of 2-aminoethoxydiphenyl borate (2-APB), which dominantly blocks SOCE but not IP(3)R at this concentration.	2-aminoethoxydiphenyl borate	66-94	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-147
22078634-7	2012	Ca(2+) oscillations were almost completely inhibited by 50 muM of 2-aminoethoxydiphenyl borate (2-APB), which dominantly blocks SOCE but not IP(3)R at this concentration.	2-aminoethoxydiphenyl borate	96-101	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-147
22078634-9	2012	We conclude that IL-13 enhances frequency of LTD4-induced Ca(2+) oscillations in human ASMCs, which may be cooperatively modulated by IP(3)R, RyR systems and possibly by SOCE.	asmcs	87-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	134-140
22374086-1	2012	The Ca(2)                         (+) signals evoked by inositol 1,4,5-trisphosphate (IP(3)) are built from elementary Ca(2)                         (+) release events involving progressive recruitment of IP(3) receptors (IP(3)R), intracellular Ca(2)                         (+) channels that are expressed in almost all animal cells.	Inositol 1,4,5-Trisphosphate	86-91	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	205-228
21701896-1	2011	The inositol 1,4,5-trisphosphate (IP(3)) receptor is highly expressed in cerebellar Purkinje cells and mediates conspicuous calcium release from intracellular calcium stores.	Calcium	124-131	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	34-49
21701896-1	2011	The inositol 1,4,5-trisphosphate (IP(3)) receptor is highly expressed in cerebellar Purkinje cells and mediates conspicuous calcium release from intracellular calcium stores.	Calcium	159-166	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	34-49
21701896-7	2011	The IP(3) receptor plays a central role in calcium signaling in Purkinje cells, affecting a wide variety of cellular functions, including development, plasticity, maintenance of synaptic functions, and cerebellar motor control.	Calcium	43-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-18
21782871-12	2011	The PLC inhibitor, U-73122, and the IP(3) receptor antagonist, 2-APB, also inhibited the sera-induced currents.	2-aminoethoxydiphenyl borate	63-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	36-50
21875593-0	2011	ESCRT machinery potentiates HIV-1 utilization of the PI(4,5)P(2)-PLC-IP3R-Ca(2+) signaling cascade.	(4,5)p	55-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	69-73
21875593-7	2011	PLC hydrolysis of phosphatidylinositol-(4,5)-bisphosphate generates inositol (1,4,5)-triphosphate, the ligand that activates IP3R.	Phosphatidylinositol 4,5-Diphosphate	18-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	125-129
21875593-7	2011	PLC hydrolysis of phosphatidylinositol-(4,5)-bisphosphate generates inositol (1,4,5)-triphosphate, the ligand that activates IP3R.	Inositol 1,4,5-Trisphosphate	68-97	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	125-129
21762810-2	2011	IP3R activation requires phospholipase C (PLC)-catalyzed hydrolysis of PI(4,5)P(2) to IP3 and diacylglycerol.	pi(4,5)p	71-79	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
21176957-3	2011	The number of secretory granules in the cell is directly related not only to the magnitude of IP(3)-induced Ca(2+) release, which accounts for the majority of the IP(3)-induced cytoplasmic Ca(2+) release in neuroendocrine cells, but also to the IP(3) sensitivity of the cytoplasmic IP(3) receptor (IP(3)R)/Ca(2+) channels.	Inositol 1,4,5-Trisphosphate	94-99	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	282-296
21176957-3	2011	The number of secretory granules in the cell is directly related not only to the magnitude of IP(3)-induced Ca(2+) release, which accounts for the majority of the IP(3)-induced cytoplasmic Ca(2+) release in neuroendocrine cells, but also to the IP(3) sensitivity of the cytoplasmic IP(3) receptor (IP(3)R)/Ca(2+) channels.	Inositol 1,4,5-Trisphosphate	94-99	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	298-304
21176957-3	2011	The number of secretory granules in the cell is directly related not only to the magnitude of IP(3)-induced Ca(2+) release, which accounts for the majority of the IP(3)-induced cytoplasmic Ca(2+) release in neuroendocrine cells, but also to the IP(3) sensitivity of the cytoplasmic IP(3) receptor (IP(3)R)/Ca(2+) channels.	Inositol 1,4,5-Trisphosphate	163-168	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	282-296
21176957-3	2011	The number of secretory granules in the cell is directly related not only to the magnitude of IP(3)-induced Ca(2+) release, which accounts for the majority of the IP(3)-induced cytoplasmic Ca(2+) release in neuroendocrine cells, but also to the IP(3) sensitivity of the cytoplasmic IP(3) receptor (IP(3)R)/Ca(2+) channels.	Inositol 1,4,5-Trisphosphate	163-168	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	298-304
21664910-3	2011	The effect of melatonin on platelets was abolished by luzindole, a melatonin receptor blocker, and rotenone, while it was unaffected by cell-permeable antagonists of either inositol 1,4,5-trisphosphate (IP(3)) receptor, phospholipase C (PLC), or bafilomycin A1, which discharges acidic calcium stores.	Melatonin	14-23	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	203-218
21762810-2	2011	IP3R activation requires phospholipase C (PLC)-catalyzed hydrolysis of PI(4,5)P(2) to IP3 and diacylglycerol.	Diglycerides	94-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-4
21762810-9	2011	Our findings suggest that Spry2 influences IP3R function through control of PI(4,5)P(2) and IP3R influences Spry2 function by controlling its distribution and ERK activation.	pi(4,5)p(2)	76-87	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	43-47
21457704-4	2011	Reduction of KRAP protein by KRAP-specific siRNA diminishes ATP-induced Ca(2+) release and the ATP-induced Ca(2+) release is completely quenched by the pretreatment with the IP(3)R inhibitor but not with the ryanodine receptor inhibitor, indicating that KRAP regulates IP(3)R-mediated Ca(2+) release.	Adenosine Triphosphate	60-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	174-180
21681021-8	2011	Furthermore, the inhibition of IP3R-mediated transient calcium flux is not required for the induction of autophagy.	Calcium	55-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	31-35
21550988-1	2011	Regulation of inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)R) by IP(3) and Ca(2+) allows them to initiate and regeneratively propagate intracellular Ca(2+) signals.	ip	44-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-68
21550988-4	2011	We used confocal microscopy and fluorescence recovery after photobleaching to define these properties for each IP(3)R subtype expressed heterologously in COS-7 cells.	carbonyl sulfide	154-157	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-117
21457704-4	2011	Reduction of KRAP protein by KRAP-specific siRNA diminishes ATP-induced Ca(2+) release and the ATP-induced Ca(2+) release is completely quenched by the pretreatment with the IP(3)R inhibitor but not with the ryanodine receptor inhibitor, indicating that KRAP regulates IP(3)R-mediated Ca(2+) release.	Adenosine Triphosphate	95-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	174-180
21457704-4	2011	Reduction of KRAP protein by KRAP-specific siRNA diminishes ATP-induced Ca(2+) release and the ATP-induced Ca(2+) release is completely quenched by the pretreatment with the IP(3)R inhibitor but not with the ryanodine receptor inhibitor, indicating that KRAP regulates IP(3)R-mediated Ca(2+) release.	Adenosine Triphosphate	95-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	269-275
21441586-5	2011	First, the work of several groups established that the dendritic calcium signal results from IP(3) receptor-mediated calcium release from internal stores.	Calcium	65-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-107
21383013-8	2011	Addition of O-GlcNAc by O-beta-N-acetylglucosaminyltransferase increased InsP(3)R-3 single channel open probability.	o-glcnac	12-20	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	73-83
21443511-6	2011	In cardiac cells, testosterone elicits voltage-dependent Ca2+ oscillations and IP3R-mediated Ca2+ release from internal stores, leading to activation of MAPK and mTOR signaling that promotes cardiac hypertrophy.	Testosterone	18-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-83
21441586-5	2011	First, the work of several groups established that the dendritic calcium signal results from IP(3) receptor-mediated calcium release from internal stores.	Calcium	117-124	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-107
21193695-4	2011	Another region of Bcl-2, the BH4 domain, also contributes to the antiapoptotic activity of Bcl-2 by binding to the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2(+) channel, inhibiting IP(3)-dependent Ca2(+) release from the endoplasmic reticulum.	sapropterin	29-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	154-158
21483779-8	2011	Finally, the presence of an IP3-releasable Ca(2+) pool in hiPSC-CMs and its contribution to whole-cell [Ca(2+)](i) transients was demonstrated by the inhibitory effects induced by the IP3-receptor blocker 2-Aminoethoxydiphenyl borate (2-APB) and the phospholipase C inhibitor U73122.	Inositol 1,4,5-Trisphosphate	28-31	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	184-196
21483779-8	2011	Finally, the presence of an IP3-releasable Ca(2+) pool in hiPSC-CMs and its contribution to whole-cell [Ca(2+)](i) transients was demonstrated by the inhibitory effects induced by the IP3-receptor blocker 2-Aminoethoxydiphenyl borate (2-APB) and the phospholipase C inhibitor U73122.	2-aminoethoxydiphenyl borate	205-233	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	184-196
21483779-8	2011	Finally, the presence of an IP3-releasable Ca(2+) pool in hiPSC-CMs and its contribution to whole-cell [Ca(2+)](i) transients was demonstrated by the inhibitory effects induced by the IP3-receptor blocker 2-Aminoethoxydiphenyl borate (2-APB) and the phospholipase C inhibitor U73122.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	276-282	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	184-196
21193695-4	2011	Another region of Bcl-2, the BH4 domain, also contributes to the antiapoptotic activity of Bcl-2 by binding to the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2(+) channel, inhibiting IP(3)-dependent Ca2(+) release from the endoplasmic reticulum.	Inositol 1,4,5-Trisphosphate	187-192	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	154-158
21193695-5	2011	We report that a novel synthetic peptide, modeled after the Bcl-2-interacting site on the IP3R, binds to the BH4 domain of Bcl-2 and functions as a competitive inhibitor of the Bcl-2-IP3R interaction.	sapropterin	109-112	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
21193695-5	2011	We report that a novel synthetic peptide, modeled after the Bcl-2-interacting site on the IP3R, binds to the BH4 domain of Bcl-2 and functions as a competitive inhibitor of the Bcl-2-IP3R interaction.	sapropterin	109-112	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	183-187
21084695-9	2011	On the basis of this novel binding mechanism, we propose a model in which the partial unfolding of the suppressor domain by apo-CaM and the stepwise binding of the N lobe of CaM to the suppressor domain are important elements of calcium/CaM inhibition of IP(3)R.	Calcium	229-236	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	255-261
21334066-2	2011	Regulation of the IP3 receptor by calcium is well characterized.	Calcium	34-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	18-30
21334066-7	2011	The main aim of this work is to constrain the AICT models with a wealth of experimental data characterizing calcium release from IP3 receptor clusters.	Calcium	108-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-141
21084695-10	2011	We believe that our working model encompasses previous regulation mechanisms of IP(3)R by calcium/CaM and provides new insights into the CaM-target interaction.	Calcium	90-97	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-86
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	25-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-121
21248136-6	2011	DHPG effects were inhibited by an mGluR5 antagonist (MTEP), IP(3) receptor blocker (xestospongin C), or ROS scavengers (PBN, tempol), but not by an mGluR1 antagonist (LY367385) or NO synthase inhibitor (l-NAME).	3,4-dihydroxyphenylglycol	0-4	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-74
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	25-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-221
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-121
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-221
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-121
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-221
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-121
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-221
21290308-7	2011	Competitive interactions between an excitatory effect of DAG and an inhibitory action of PIP(2) can also be modulated by IP(3) acting via an IP(3) receptor-independent mechanism.	Diglycerides	57-60	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-155
20843799-1	2010	The three isoforms of the inositol 1,4,5-trisphosphate receptor (IP(3)R) exhibit distinct IP(3) sensitivities and cooperativities in calcium (Ca(2+)) channel function.	Calcium	133-140	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-71
20727967-7	2011	Rapamycin also decreased carbachol-induced Ca(2+) release in HEK 293A cells in which IP(3)R-1 and IP(3)R-3 had been knocked down.	Sirolimus	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-106
20727967-7	2011	Rapamycin also decreased carbachol-induced Ca(2+) release in HEK 293A cells in which IP(3)R-1 and IP(3)R-3 had been knocked down.	Carbachol	25-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-106
20705074-2	2010	The pacemaking signals are generated by membrane depolarizations, which are in turn linked to the integrated transport of calcium between the endoplasmic reticulum (ER), through inositol-trisphosphate receptor (IP(3)R) release, and mitochondria, through the uniporter.	Calcium	122-129	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	211-217
20705074-7	2010	Without strong and persistent stimulation of the IP(3)R, reductions of calcium below baseline occur only with a non-physiological, time-dependent uniporter.	Calcium	71-78	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-55
20705074-8	2010	Alternatively, sufficient IP(3)R release leads to reductions of calcium below baseline, due to depletion of the ER calcium store over the time scale of seconds, although these reductions require strong mitochondrial and ER calcium uptake.	Calcium	64-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	26-32
20705074-8	2010	Alternatively, sufficient IP(3)R release leads to reductions of calcium below baseline, due to depletion of the ER calcium store over the time scale of seconds, although these reductions require strong mitochondrial and ER calcium uptake.	Calcium	115-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	26-32
20705074-8	2010	Alternatively, sufficient IP(3)R release leads to reductions of calcium below baseline, due to depletion of the ER calcium store over the time scale of seconds, although these reductions require strong mitochondrial and ER calcium uptake.	Calcium	115-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	26-32
20843799-5	2010	Our NMR and biochemical studies showed that three spatially clustered residues (Glu-20, Tyr-167, and Ser-217 in IP(3)R1 and Glu-19, Trp-168, and Ser-218 in IP(3)R3) within the N-terminal suppressor domains of IP(3)R1(SUP) and IP(3)R3(SUP) interact directly with their respective C-terminal fragments.	Glutamic Acid	124-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-163
20843799-5	2010	Our NMR and biochemical studies showed that three spatially clustered residues (Glu-20, Tyr-167, and Ser-217 in IP(3)R1 and Glu-19, Trp-168, and Ser-218 in IP(3)R3) within the N-terminal suppressor domains of IP(3)R1(SUP) and IP(3)R3(SUP) interact directly with their respective C-terminal fragments.	Glutamic Acid	124-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	226-233
20843799-5	2010	Our NMR and biochemical studies showed that three spatially clustered residues (Glu-20, Tyr-167, and Ser-217 in IP(3)R1 and Glu-19, Trp-168, and Ser-218 in IP(3)R3) within the N-terminal suppressor domains of IP(3)R1(SUP) and IP(3)R3(SUP) interact directly with their respective C-terminal fragments.	Tryptophan	132-135	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-163
20843799-5	2010	Our NMR and biochemical studies showed that three spatially clustered residues (Glu-20, Tyr-167, and Ser-217 in IP(3)R1 and Glu-19, Trp-168, and Ser-218 in IP(3)R3) within the N-terminal suppressor domains of IP(3)R1(SUP) and IP(3)R3(SUP) interact directly with their respective C-terminal fragments.	Serine	145-148	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-163
21984909-9	2011	Furthermore, 2-Aminoethoxydiphenyl borate, a reliable blocker of SOCE and an inhibitor of inositol 1,4,5-trisphosphate (IP3) receptor, evidently abolished SNP and NEM-induced calcium entry at 75 microM, while preventing calcium release in a concentration-dependent manner.	2-aminoethoxydiphenyl borate	13-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	120-133
21984909-9	2011	Furthermore, 2-Aminoethoxydiphenyl borate, a reliable blocker of SOCE and an inhibitor of inositol 1,4,5-trisphosphate (IP3) receptor, evidently abolished SNP and NEM-induced calcium entry at 75 microM, while preventing calcium release in a concentration-dependent manner.	Ethylmaleimide	163-166	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	120-133
21984909-9	2011	Furthermore, 2-Aminoethoxydiphenyl borate, a reliable blocker of SOCE and an inhibitor of inositol 1,4,5-trisphosphate (IP3) receptor, evidently abolished SNP and NEM-induced calcium entry at 75 microM, while preventing calcium release in a concentration-dependent manner.	Calcium	175-182	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	120-133
21984909-9	2011	Furthermore, 2-Aminoethoxydiphenyl borate, a reliable blocker of SOCE and an inhibitor of inositol 1,4,5-trisphosphate (IP3) receptor, evidently abolished SNP and NEM-induced calcium entry at 75 microM, while preventing calcium release in a concentration-dependent manner.	Calcium	220-227	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	120-133
20937770-8	2010	Further analysis indicates that nuclear accumulation of CPEB4 is controlled by the depletion of calcium from the ER, specifically, through the inositol-1,4,5-triphosphate (IP3) receptor, indicating a communication between these organelles in redistributing proteins between subcellular compartments.	Calcium	96-103	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-185
21092239-6	2010	U73122, a phospholipase C inhibitor, and 2-aminoethoxydiphenyl borate (2-APB), an antagonist of inositol-1,4,5-trisphosphate (IP3) receptor, were tested to determine the mechanism of this Ca2+ signaling pathway.	2-aminoethoxydiphenyl borate	71-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-139
20843799-8	2010	285, 36081-36091), we demonstrate that the single aromatic residue in this region (Tyr-167 in IP(3)R1 and Trp-168 in IP(3)R3) plays a critical role in the coupling between ligand binding and channel gating.	Tyrosine	83-86	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-124
20843799-8	2010	285, 36081-36091), we demonstrate that the single aromatic residue in this region (Tyr-167 in IP(3)R1 and Trp-168 in IP(3)R3) plays a critical role in the coupling between ligand binding and channel gating.	Tryptophan	106-109	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-124
20530483-9	2010	We conclude the following: a) that large conformational changes induced by Ca(2+) can be detected in IP(3)Rs in situ; b) these changes may be driven by Ca(2+) binding to the N-terminal suppressor domain and expose a group of closely spaced endogenous thiols in the channel domain; and c) that the C-terminal cytosol-exposed tail of the IP(3)R may be relatively inaccessible to regulatory proteins unless Ca(2+) is present.	Sulfhydryl Compounds	251-257	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-107
20603333-8	2010	Specifically, long-term potentiation is dependent on NMDA receptor activation, while long-term depression requires distinct coincidence detectors: the phospholipase Cbeta (PLCbeta) and the inositol-trisphosphate receptor (IP3R)-gated calcium stores.	Calcium	234-241	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	222-226
20395455-1	2010	Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) drive calcium signals involved in skeletal muscle excitation-transcription coupling and plasticity; IP(3)R subtype distribution and downstream events evoked by their activation have not been studied in human muscle nor has their possible alteration in Duchenne muscular dystrophy (DMD).	Calcium	63-70	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-54
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	Caffeine	66-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-47
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	Caffeine	66-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	2-aminoethoxydiphenyl borate	76-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-47
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	2-aminoethoxydiphenyl borate	76-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	xestospongin C	86-100	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-47
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	xestospongin C	86-100	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	xestospongin C	102-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-47
20565939-4	2010	RESULTS: Our results show that the IP3 receptor (IP3R) inhibitors caffeine, 2-APB and xestospongin C (XeC) inhibited the growth of MCF-7 stimulated by 5% foetal calf serum or 10 nM E2.	xestospongin C	102-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
20304819-5	2010	Such IP(3)R-gated Ca(2+) releases were amplified by Ca(2+)-induced Ca(2+) release (CICR) via RyRs since they were also reduced by compounds that block the RyRs (tetracaine) or deplete the Ca(2+) pools they gate (caffeine, ryanodine).	cicr	83-87	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	5-11
20304819-5	2010	Such IP(3)R-gated Ca(2+) releases were amplified by Ca(2+)-induced Ca(2+) release (CICR) via RyRs since they were also reduced by compounds that block the RyRs (tetracaine) or deplete the Ca(2+) pools they gate (caffeine, ryanodine).	Tetracaine	161-171	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	5-11
20304819-4	2010	Application of ATP and endothelin-1 to voltage-clamped, or IP(3) to permeabilized, cells produced smaller and slower Ca(2+) signals that were most prominent in subsarcolemmal regions and were suppressed by either the IP(3)R-blocker 2-aminoethoxydiphenylborate or replacement of the biologically active form of IP(3) with its L-stereoisomer.	Adenosine Triphosphate	15-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	217-223
20304819-5	2010	Such IP(3)R-gated Ca(2+) releases were amplified by Ca(2+)-induced Ca(2+) release (CICR) via RyRs since they were also reduced by compounds that block the RyRs (tetracaine) or deplete the Ca(2+) pools they gate (caffeine, ryanodine).	Caffeine	212-220	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	5-11
20304819-4	2010	Application of ATP and endothelin-1 to voltage-clamped, or IP(3) to permeabilized, cells produced smaller and slower Ca(2+) signals that were most prominent in subsarcolemmal regions and were suppressed by either the IP(3)R-blocker 2-aminoethoxydiphenylborate or replacement of the biologically active form of IP(3) with its L-stereoisomer.	2-aminoethoxydiphenyl borate	232-259	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	217-223
20304819-5	2010	Such IP(3)R-gated Ca(2+) releases were amplified by Ca(2+)-induced Ca(2+) release (CICR) via RyRs since they were also reduced by compounds that block the RyRs (tetracaine) or deplete the Ca(2+) pools they gate (caffeine, ryanodine).	Ryanodine	222-231	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	5-11
20039269-6	2010	The IP3R agonist thimerosal enhanced Ca(i) (2+) oscillations.	Thimerosal	17-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-8
20189985-1	2010	In HEK cells stably expressing type 1 receptors for parathyroid hormone (PTH), PTH causes a sensitization of inositol 1,4,5-trisphosphate receptors (IP(3)R) to IP(3) that is entirely mediated by cAMP and requires cAMP to pass directly from type 6 adenylyl cyclase (AC6) to IP(3)R2.	Cyclic AMP	195-199	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	149-155
20189985-1	2010	In HEK cells stably expressing type 1 receptors for parathyroid hormone (PTH), PTH causes a sensitization of inositol 1,4,5-trisphosphate receptors (IP(3)R) to IP(3) that is entirely mediated by cAMP and requires cAMP to pass directly from type 6 adenylyl cyclase (AC6) to IP(3)R2.	Cyclic AMP	213-217	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	149-155
20189985-2	2010	Using DT40 cells expressing single subtypes of mammalian IP(3)R, we demonstrate that high concentrations of cAMP similarly sensitize all IP(3)R isoforms to IP(3) by a mechanism that does not require cAMP-dependent protein kinase (PKA).	Cyclic AMP	108-112	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	57-63
20189985-2	2010	Using DT40 cells expressing single subtypes of mammalian IP(3)R, we demonstrate that high concentrations of cAMP similarly sensitize all IP(3)R isoforms to IP(3) by a mechanism that does not require cAMP-dependent protein kinase (PKA).	Cyclic AMP	108-112	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	137-143
20189985-5	2010	These results establish that cAMP itself increases the sensitivity of all IP(3)R subtypes to IP(3).	Cyclic AMP	29-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-80
20189985-9	2010	We conclude that all three subtypes of IP(3)R are regulated by cAMP independent of PKA.	Cyclic AMP	63-67	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	39-45
20039269-6	2010	The IP3R agonist thimerosal enhanced Ca(i) (2+) oscillations.	carboxyamido-triazole	37-42	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-8
19955332-5	2010	The thermotactic response was also inhibited by each of the following: La(3+), a general blocker of Ca(2+) channels; U73122, an inhibitor of phospholipase C (PLC); and 2-aminoethoxy diphenyl borate, an inhibitor of inositol 1,4,5-trisphosphate receptors (IP(3)R) and store-operated channels.	lanthanum(3+)	71-77	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	255-261
20176853-11	2010	Consequently, we conclude that NO, acting via the cGMP-PKG pathway, induced airway SMC relaxation by predominately inhibiting the release of Ca(2+) via the IP(3) receptor to decrease the frequency of agonist-induced Ca(2+) oscillations.	Cyclic GMP	50-54	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-170
20174630-3	2010	Calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3R"s) is a key component that participates in both local signals such as "puffs" and in global waves.	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	68-72
20174630-11	2010	The largest distance over which Ca2+-mediated coupling acts and the density of IP3-bound IP3R"s of the cluster can also be estimated.	Inositol 1,4,5-Trisphosphate	79-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-93
19958796-7	2010	Interestingly, promoting calcium oscillations through IP(3)R agonists increased both proliferation and levels of cell cycle regulators such as cyclins A and E. Conversely, blocking calcium events with IP(3)R antagonists had the opposite effect in both undifferentiated and neural progenitor cells.	Calcium	25-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	54-60
19958796-7	2010	Interestingly, promoting calcium oscillations through IP(3)R agonists increased both proliferation and levels of cell cycle regulators such as cyclins A and E. Conversely, blocking calcium events with IP(3)R antagonists had the opposite effect in both undifferentiated and neural progenitor cells.	Calcium	25-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	201-207
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	99-113
19997608-4	2009	Our data implicate a number of classic signal transduction pathways in the response and provide a model for the sequence of events, where the tmAC-cAMP-PKA pathway is activated first, followed by protein tyrosine phosphorylation (equatorial band and flagellum) and calcium mobilization (through IP(3)R and SOC channels), whereas the sGC-cGMP-PKG cascade, is activated later.	tmac	142-146	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	295-301
19997608-4	2009	Our data implicate a number of classic signal transduction pathways in the response and provide a model for the sequence of events, where the tmAC-cAMP-PKA pathway is activated first, followed by protein tyrosine phosphorylation (equatorial band and flagellum) and calcium mobilization (through IP(3)R and SOC channels), whereas the sGC-cGMP-PKG cascade, is activated later.	Cyclic AMP	147-151	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	295-301
20201888-4	2010	The involvement of 1,4,5-IP3-dependent intracellular Ca2+ release in AT-I-induced effects was supported by these findings: the effects of AT-II were blocked by 2-aminoethoxyphenyl borate (2-APB, a 1,4,5-IP3 receptor blocker) and U73122 (a phosopholipase C blocker); and hESC-CM express AT-II type 1 and IP3 type I and II receptors as determined by fluorescence immunostaining.	Inositol 1,4,5-Trisphosphate	19-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	203-215
20201888-4	2010	The involvement of 1,4,5-IP3-dependent intracellular Ca2+ release in AT-I-induced effects was supported by these findings: the effects of AT-II were blocked by 2-aminoethoxyphenyl borate (2-APB, a 1,4,5-IP3 receptor blocker) and U73122 (a phosopholipase C blocker); and hESC-CM express AT-II type 1 and IP3 type I and II receptors as determined by fluorescence immunostaining.	2-aminoethoxyphenyl borate	160-186	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	203-215
20201888-4	2010	The involvement of 1,4,5-IP3-dependent intracellular Ca2+ release in AT-I-induced effects was supported by these findings: the effects of AT-II were blocked by 2-aminoethoxyphenyl borate (2-APB, a 1,4,5-IP3 receptor blocker) and U73122 (a phosopholipase C blocker); and hESC-CM express AT-II type 1 and IP3 type I and II receptors as determined by fluorescence immunostaining.	2-aminoethoxydiphenyl borate	188-193	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	203-215
19782748-4	2010	PGF-mediated potentiation of cAMP release was abolished by antagonism of the FP receptor, inhibition of phospholipase C (PLC) and inositol phosphate receptor (IP3R) whereas inhibition of protein kinase C (PKC) had no effect.	Prostaglandins F	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-163
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	291-305
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	291-305
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	291-305
19785652-6	2009	KEY RESULTS: FK506 which displaces FKBP from each receptor (to inhibit calcineurin) increased the [Ca(2+)](cyto) rise evoked by activation of either RyR or IP(3)R.	Tacrolimus	13-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-162
19706611-6	2009	Knockdown of GIT induced and accelerated caspase-dependent apoptosis in both unstimulated and staurosporine-treated cells, which was attenuated by wild-type GIT1 overexpression or pharmacological inhibitors of IP(3)R, but not by a mutant form of GIT1 that abrogates the interaction.	Staurosporine	94-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	210-216
19442655-6	2009	Calcineurin is a cytosolic phosphatase, which was able to dephosphorylate the inositol-1,4,5-triphosphate receptor (IP(3)R) calcium channel to prevent the release of calcium from ER.	Calcium	124-131	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	116-122
19747726-5	2009	Furthermore, ryanodine and 2APB, RyR and IP(3)R inhibitors respectively, attenuated NMDA-triggered intracellular Ca(2+) increase and oxidative stress, whereas 2APB reduced mitochondrial membrane depolarization and caspase-3 cleavage.	N-Methylaspartate	84-88	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	41-47
19442655-8	2009	However, EGTA and the IP(3)R inhibitor, 2-APB, were able to partially modulate Cd cytotoxicity.	2-aminoethoxydiphenyl borate	40-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-28
19442655-8	2009	However, EGTA and the IP(3)R inhibitor, 2-APB, were able to partially modulate Cd cytotoxicity.	Cadmium	79-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-28
19792034-3	2009	We model calcium puffs using a simple, sequential-binding model for the IP(3) receptor in conjunction with a computationally inexpensive point-source approximation.	Calcium	9-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-86
19475562-5	2009	They were suppressed by the SOC entry channel blocker La3+, the phospholipase C (PLC) inhibitor U73122, the inositol trisphosphate receptor (IP3R) blocker 2-amino-ethoxydiphenyl borate, or the sarcoplasmic/endoplasmic reticulum Ca2+ pump (SERCA) inhibitors thapsigargin and cyclopiazonic acid, but not by ryanodine.	ethoxydiphenyl borate	163-184	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
19475562-5	2009	They were suppressed by the SOC entry channel blocker La3+, the phospholipase C (PLC) inhibitor U73122, the inositol trisphosphate receptor (IP3R) blocker 2-amino-ethoxydiphenyl borate, or the sarcoplasmic/endoplasmic reticulum Ca2+ pump (SERCA) inhibitors thapsigargin and cyclopiazonic acid, but not by ryanodine.	Thapsigargin	257-269	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
19475562-5	2009	They were suppressed by the SOC entry channel blocker La3+, the phospholipase C (PLC) inhibitor U73122, the inositol trisphosphate receptor (IP3R) blocker 2-amino-ethoxydiphenyl borate, or the sarcoplasmic/endoplasmic reticulum Ca2+ pump (SERCA) inhibitors thapsigargin and cyclopiazonic acid, but not by ryanodine.	cyclopiazonic acid	274-292	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
19475562-5	2009	They were suppressed by the SOC entry channel blocker La3+, the phospholipase C (PLC) inhibitor U73122, the inositol trisphosphate receptor (IP3R) blocker 2-amino-ethoxydiphenyl borate, or the sarcoplasmic/endoplasmic reticulum Ca2+ pump (SERCA) inhibitors thapsigargin and cyclopiazonic acid, but not by ryanodine.	Ryanodine	305-314	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
19475562-6	2009	The IP3R activator thimerosal increased Ca(i)2+ oscillations.	Thimerosal	19-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-8
19475562-6	2009	The IP3R activator thimerosal increased Ca(i)2+ oscillations.	ca(i)2	40-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-8
19668195-4	2009	We synthesized 2-O-modified IP(3) analogs that are partial agonists of IP(3)R.	hippuric acid	15-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-77
19458227-5	2009	Implicating IP(3)R-dependent stores, an IP(3)R antagonist, 2-APB, also decreased evoked [DA](o).	2-aminoethoxydiphenyl borate	59-64	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	12-18
19706527-0	2009	The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.	sapropterin	4-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	119-131
19706527-0	2009	The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.	Calcium	36-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	119-131
19706527-4	2009	Here we report that the BH4 domain mediates interaction of Bcl-2 with the inositol 1,4,5-trisphosphate (IP3) receptor, an IP3-gated Ca(2+) channel on the endoplasmic reticulum (ER).	sapropterin	24-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	104-117
19706527-5	2009	BH4 peptide binds to the regulatory and coupling domain of the IP3 receptor and inhibits IP3-dependent channel opening, Ca(2+) release from the ER, and Ca(2+)-mediated apoptosis.	sapropterin	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-75
19706527-6	2009	A peptide inhibitor of Bcl-2-IP3 receptor interaction prevents these BH4-mediated effects.	sapropterin	69-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	29-41
19429774-6	2009	The [Ca(2+)](i) increase was also abolished by pretreatment with 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate (IP(3)) receptor antagonist.	2-aminoethoxydiphenyl borate	65-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-151
19429774-6	2009	The [Ca(2+)](i) increase was also abolished by pretreatment with 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate (IP(3)) receptor antagonist.	Inositol 1,4,5-Trisphosphate	106-134	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-151
19473987-4	2009	Extensive phosphopeptide mapping of the IP(3)R resulted in approximately 70% coverage and identified three residues, Thr-931, Thr-1136, and Ser-114, which are specifically phosphorylated during maturation.	Threonine	117-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-46
19473987-4	2009	Extensive phosphopeptide mapping of the IP(3)R resulted in approximately 70% coverage and identified three residues, Thr-931, Thr-1136, and Ser-114, which are specifically phosphorylated during maturation.	Threonine	126-129	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-46
19473987-4	2009	Extensive phosphopeptide mapping of the IP(3)R resulted in approximately 70% coverage and identified three residues, Thr-931, Thr-1136, and Ser-114, which are specifically phosphorylated during maturation.	Serine	140-143	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-46
19325567-4	2009	Here, we show that the IP(3)R antagonist xestospongin B induces autophagy by disrupting a molecular complex formed by the IP(3)R and Beclin 1, an interaction that is increased or inhibited by overexpression or knockdown of Bcl-2, respectively.	xestospongin B	41-55	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	23-29
19325567-4	2009	Here, we show that the IP(3)R antagonist xestospongin B induces autophagy by disrupting a molecular complex formed by the IP(3)R and Beclin 1, an interaction that is increased or inhibited by overexpression or knockdown of Bcl-2, respectively.	xestospongin B	41-55	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-128
19325567-6	2009	Xestospongin B- or starvation-induced autophagy was inhibited by overexpression of the IP(3)R ligand-binding domain, which coimmunoprecipitated with Beclin 1.	xestospongin B	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	87-93
19056433-5	2009	This function is mediated through interaction of the Bcl-2 BH4 domain with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channel.	sapropterin	59-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	118-122
19458227-5	2009	Implicating IP(3)R-dependent stores, an IP(3)R antagonist, 2-APB, also decreased evoked [DA](o).	2-aminoethoxydiphenyl borate	59-64	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-46
19458227-7	2009	Release suppression by mGluR1 blockade was prevented by 2-APB or CPA, indicating facilitation of DA release by endogenous glutamate acting via mGluR1s and IP(3)R-gated Ca(2+) stores.	2-aminoethoxydiphenyl borate	56-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	155-161
19458227-7	2009	Release suppression by mGluR1 blockade was prevented by 2-APB or CPA, indicating facilitation of DA release by endogenous glutamate acting via mGluR1s and IP(3)R-gated Ca(2+) stores.	cyclopiazonic acid	65-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	155-161
19458227-7	2009	Release suppression by mGluR1 blockade was prevented by 2-APB or CPA, indicating facilitation of DA release by endogenous glutamate acting via mGluR1s and IP(3)R-gated Ca(2+) stores.	Glutamic Acid	122-131	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	155-161
19353780-7	2009	Blocking the muscarinic type 1 ACh receptor (M1), M3/5, intracellular inositol triphosphate (IP3) receptor, or protein kinase C (PKC) pathways inhibited VSMC-mediated CIHP, whereas blocking the M3/5, IP3 receptor, or PKC pathways inhibited VEC-mediated CIHP.	vsmc	153-157	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-106
19147678-6	2009	Moreover, the Hsp90 inhibitor geldanamycin (GA) disrupted the interaction between Hsp90 and the IP(3)R.	geldanamycin	30-42	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-102
19147678-6	2009	Moreover, the Hsp90 inhibitor geldanamycin (GA) disrupted the interaction between Hsp90 and the IP(3)R.	geldanamycin	44-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-102
19353780-7	2009	Blocking the muscarinic type 1 ACh receptor (M1), M3/5, intracellular inositol triphosphate (IP3) receptor, or protein kinase C (PKC) pathways inhibited VSMC-mediated CIHP, whereas blocking the M3/5, IP3 receptor, or PKC pathways inhibited VEC-mediated CIHP.	vsmc	153-157	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	194-212
19353780-7	2009	Blocking the muscarinic type 1 ACh receptor (M1), M3/5, intracellular inositol triphosphate (IP3) receptor, or protein kinase C (PKC) pathways inhibited VSMC-mediated CIHP, whereas blocking the M3/5, IP3 receptor, or PKC pathways inhibited VEC-mediated CIHP.	cihp	167-171	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-106
19236728-6	2009	The reduced Ca2+-content correlated with a reduced expression of SERCA 2 pumping calcium into the ER, an increased expression of IP3R releasing calcium from the ER, and a reduced expression of calreticulin buffering calcium within the ER.	Calcium	144-151	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-133
19100621-3	2009	In this study, we have described the actions of the IP(3)R and store-operated Ca(2+) channel antagonist, 2-aminoethoxydiphenyl-borate (2-APB), on internal Ca(2+) release and plasma membrane excitability in neocortical and hippocampal pyramidal neurons.	2-aminoethoxydiphenyl borate	105-133	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	52-58
19236728-6	2009	The reduced Ca2+-content correlated with a reduced expression of SERCA 2 pumping calcium into the ER, an increased expression of IP3R releasing calcium from the ER, and a reduced expression of calreticulin buffering calcium within the ER.	Calcium	144-151	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-133
19602879-4	2009	In the presence of tetracaine, IP(3)R-dependent Ca2+ events in AF atrial myocytes showed increased frequency, delayed termination and broadened width, compared with NSR myocytes.	Tetracaine	19-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	31-37
18782655-3	2008	Recent researches have indicated that a clinically relevant isoflurane treatment may induce neurodegeneration and apoptosis by activating the endoplasmic reticulum (ER) membrane inositol 1,4,5-trisphosphate (IP(3)) receptor, producing excessive calcium release from ER to the cytoplasm and triggering apoptosis.	Isoflurane	60-70	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	208-223
18692061-0	2008	IP(3)R-mediated Ca(2+) release is modulated by anandamide in isolated cardiac nuclei.	anandamide	47-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-6
18782655-3	2008	Recent researches have indicated that a clinically relevant isoflurane treatment may induce neurodegeneration and apoptosis by activating the endoplasmic reticulum (ER) membrane inositol 1,4,5-trisphosphate (IP(3)) receptor, producing excessive calcium release from ER to the cytoplasm and triggering apoptosis.	Calcium	245-252	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	208-223
18507737-5	2008	Following REOX, a biphasic change in Ca(2+)(ER) occurred with an initial release of Ca(2+)(ER) which was sensitive to inositol 1,4,5-trisphosphate receptor (IP(3)R) inhibition and a subsequent refilling of Ca(2+)(ER) stores.	Inositol	118-126	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	157-163
18787062-8	2008	The PLC inhibitor U73122 and the inositol 1,4,5-triphosphate (IP3) receptor inhibitor 2-APB both blocked the ATP-stimulated increase in [Ca(2+)](i) and membrane Cl(-) currents.	2-aminoethoxydiphenyl borate	86-91	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-75
18787062-8	2008	The PLC inhibitor U73122 and the inositol 1,4,5-triphosphate (IP3) receptor inhibitor 2-APB both blocked the ATP-stimulated increase in [Ca(2+)](i) and membrane Cl(-) currents.	Adenosine Triphosphate	109-112	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-75
18539593-1	2008	Sigma-1 receptor (sigma-1R) agonists enhance inositol 1,4,5-trisphosphate (IP3)-dependent calcium release from endoplasmic reticulum by inducing dissociation of ankyrin B 220 (ANK 220) from the IP3 receptor (IP3R-3), releasing it from inhibition.	Inositol 1,4,5-Trisphosphate	75-78	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	194-206
18539593-1	2008	Sigma-1 receptor (sigma-1R) agonists enhance inositol 1,4,5-trisphosphate (IP3)-dependent calcium release from endoplasmic reticulum by inducing dissociation of ankyrin B 220 (ANK 220) from the IP3 receptor (IP3R-3), releasing it from inhibition.	Inositol 1,4,5-Trisphosphate	75-78	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	208-214
18698039-6	2008	RESULTS: Gefitinib increases accumulation of 99mTc-Sestamibi in Bcl-2-overexpressing cells and enhances the physical interaction of phosphorylated Bcl-2 with inositol trisphosphate receptor type 3 (IP3R3).	Gefitinib	9-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-203
18698039-8	2008	Similarly, lung cancer cells showed an increase of tracer uptake and an enhanced interaction of Bcl-xL with IP3R3 on exposure to erlotinib concentrations achievable in plasma.	Erlotinib Hydrochloride	129-138	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	108-113
18572304-8	2008	This G protein-coupled receptor activates a phospholipase C that in turn increases inositol trisphosphate (IP3) levels mediating the release of intracellular stores of Ca2+ via an IP3 receptor gated Ca2+ channel.	inositol 1,2,3-trisphosphate	83-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	180-192
18572304-8	2008	This G protein-coupled receptor activates a phospholipase C that in turn increases inositol trisphosphate (IP3) levels mediating the release of intracellular stores of Ca2+ via an IP3 receptor gated Ca2+ channel.	Inositol 1,4,5-Trisphosphate	107-110	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	180-192
18562632-7	2008	Our model predicts that oscillations are more prone to occur when IP3R and RyR stores are separate because, in that case, Ca2+ released by RyR during CICR can enhance filling of adjacent IP3 stores to favor a high subsequent leak that generates further CICR events.	cicr	150-154	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	66-70
18562632-7	2008	Our model predicts that oscillations are more prone to occur when IP3R and RyR stores are separate because, in that case, Ca2+ released by RyR during CICR can enhance filling of adjacent IP3 stores to favor a high subsequent leak that generates further CICR events.	cicr	253-257	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	66-70
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	116-122
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	11-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	116-122
18755685-6	2008	CCh-stimulated recruitment of TRPC3-RACK1-IP(3)R complex as well as increased surface expression of TRPC3 and receptor-operated Ca(2+) entry were also attenuated.	Carbachol	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-48
18826956-7	2008	We conclude that IP3-mediated sensitization requires IP3 receptor binding to a TRPV4 C-terminal domain that overlaps with a previously described calmodulin-binding site.	Inositol 1,4,5-Trisphosphate	17-20	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	53-65
18653477-10	2008	Downregulation of both IP3R1 and IP3R3 was found in TGF-beta-treated PGASMC.	pgasmc	69-75	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	33-38
18723000-2	2008	A number of recent studies have highlighted the importance of the inositol 1,4,5-trisphosphate (IP3) receptor(IP3R) in mediating calcium (Ca2+) transfer from the endoplasmic reticulum (ER) to the mitochondriain several models of apoptosis.	Calcium	129-136	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-109
18723000-2	2008	A number of recent studies have highlighted the importance of the inositol 1,4,5-trisphosphate (IP3) receptor(IP3R) in mediating calcium (Ca2+) transfer from the endoplasmic reticulum (ER) to the mitochondriain several models of apoptosis.	Calcium	129-136	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
18936250-3	2008	We show that PTH communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3).	Cyclic AMP	47-51	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-41
18936250-3	2008	We show that PTH communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3).	Cyclic AMP	47-51	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	132-138
18936250-3	2008	We show that PTH communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3).	Cyclic AMP	124-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-41
18936250-3	2008	We show that PTH communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3).	Cyclic AMP	124-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	132-138
18320300-9	2008	We also show that inhomogeneity in IP(3)R density can account for calcium wave directionality.	Calcium	66-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-41
18452161-4	2008	Paclitaxel treatment not only activated calpain and caspase-4, but also induced a gradual increase in the cytosolic Ca(2+) concentration at 3-6 h. Paclitaxel-induced apoptosis can be inhibited by the calpain inhibitor calpeptin and IP(3) receptor inhibitors.	Paclitaxel	0-10	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	232-246
18667147-4	2008	Finally, new studies have elucidated the role by which presenilins modulate calcium signaling, including effects on SERCA2b and gating of the IP(3) receptor, and lead to Abeta production.	Calcium	76-83	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	142-156
18657507-4	2008	A peptide based on this IP3R sequence displaced Bcl-2 from the IP3R and reversed Bcl-2-mediated inhibition of IP3R channel activity in vitro, IP3-induced ER Ca2+ release in permeabilized cells, and cell-permeable IP3 ester-induced Ca2+ elevation in intact cells.	Inositol 1,4,5-Trisphosphate	24-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
18657507-4	2008	A peptide based on this IP3R sequence displaced Bcl-2 from the IP3R and reversed Bcl-2-mediated inhibition of IP3R channel activity in vitro, IP3-induced ER Ca2+ release in permeabilized cells, and cell-permeable IP3 ester-induced Ca2+ elevation in intact cells.	Inositol 1,4,5-Trisphosphate	24-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
18657507-4	2008	A peptide based on this IP3R sequence displaced Bcl-2 from the IP3R and reversed Bcl-2-mediated inhibition of IP3R channel activity in vitro, IP3-induced ER Ca2+ release in permeabilized cells, and cell-permeable IP3 ester-induced Ca2+ elevation in intact cells.	ip3 ester	213-222	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	24-28
18657507-4	2008	A peptide based on this IP3R sequence displaced Bcl-2 from the IP3R and reversed Bcl-2-mediated inhibition of IP3R channel activity in vitro, IP3-induced ER Ca2+ release in permeabilized cells, and cell-permeable IP3 ester-induced Ca2+ elevation in intact cells.	ip3 ester	213-222	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
18657507-4	2008	A peptide based on this IP3R sequence displaced Bcl-2 from the IP3R and reversed Bcl-2-mediated inhibition of IP3R channel activity in vitro, IP3-induced ER Ca2+ release in permeabilized cells, and cell-permeable IP3 ester-induced Ca2+ elevation in intact cells.	ip3 ester	213-222	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
18452161-4	2008	Paclitaxel treatment not only activated calpain and caspase-4, but also induced a gradual increase in the cytosolic Ca(2+) concentration at 3-6 h. Paclitaxel-induced apoptosis can be inhibited by the calpain inhibitor calpeptin and IP(3) receptor inhibitors.	Paclitaxel	147-157	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	232-246
18388325-0	2008	IP3 constricts cerebral arteries via IP3 receptor-mediated TRPC3 channel activation and independently of sarcoplasmic reticulum Ca2+ release.	Inositol 1,4,5-Trisphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	37-49
18544901-3	2008	Stimulation with ATP evoked GFP-IP(3)R3 clustering not only in cells with replete Ca(2+)-stores but also in cells with depleted Ca(2+) stores.	Adenosine Triphosphate	17-20	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-39
18544901-5	2008	Application of IP(3) caused GFP-IP(3)R3 clustering in permeabilized cells, and the response was completely inhibited by heparin, a competitive inhibitor of IP(3)R.	Heparin	120-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-39
18544901-5	2008	Application of IP(3) caused GFP-IP(3)R3 clustering in permeabilized cells, and the response was completely inhibited by heparin, a competitive inhibitor of IP(3)R.	Heparin	120-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	32-38
18364356-3	2008	Here, we show that Fas-dependent killing of Jurkat T lymphoma cells by SW620 colon cancer cells requires calcium release from IP3R.	ammonium ferrous sulfate	19-22	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-130
18364356-3	2008	Here, we show that Fas-dependent killing of Jurkat T lymphoma cells by SW620 colon cancer cells requires calcium release from IP3R.	Calcium	105-112	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-130
18364356-5	2008	Significantly, a specific inhibitor of apoptotic calcium release from IP3R strongly blocked lymphocyte apoptosis.	Calcium	49-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-74
18364356-6	2008	Thus, selective pharmacological targeting of apoptotic calcium release from IP3R may enhance tumor cell immunogenicity.	Calcium	55-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-80
18406528-0	2008	Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture.	Levetiracetam	0-13	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-54
18406528-0	2008	Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture.	Calcium	65-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-54
18406528-0	2008	Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture.	Calcium	81-88	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-54
18406528-3	2008	Intracellular calcium ([Ca2+]i) regulation by both inositol 1,4,5-triphosphate receptors (IP3R) and ryanodine receptors (RyR) has been implicated in epileptogenesis and the maintenance of epilepsy.	Calcium	14-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
18406528-4	2008	To this end, we investigated the effect of LEV on RyR and IP3R activated calcium-induced calcium release (CICR) in hippocampal neuronal cultures.	Calcium	73-80	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
18406528-4	2008	To this end, we investigated the effect of LEV on RyR and IP3R activated calcium-induced calcium release (CICR) in hippocampal neuronal cultures.	Calcium	89-96	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
18406528-8	2008	Bradykinin stimulates IP3R-activated CICR-to test the effect of LEV on IP3R-mediated CICR, bradykinin (1 microM) was used to stimulate cells pre-treated with LEV (100 microM).	cicr	37-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-26
18406528-8	2008	Bradykinin stimulates IP3R-activated CICR-to test the effect of LEV on IP3R-mediated CICR, bradykinin (1 microM) was used to stimulate cells pre-treated with LEV (100 microM).	cicr	85-89	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-75
18406528-9	2008	The data showed that LEV caused a 74% decrease in IP3R-mediated CICR compared to the control.	Levetiracetam	21-24	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
18406528-9	2008	The data showed that LEV caused a 74% decrease in IP3R-mediated CICR compared to the control.	cicr	64-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
18388325-5	2008	The IP(3)-induced I(Cat) and [Ca(2+)](i) elevation were attenuated by cation channel (Gd(3+), 2-APB) and IP(3) receptor (xestospongin C, heparin, 2-APB) blockers.	Heparin	137-144	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-119
18388325-9	2008	In summary, we describe a novel mechanism of IP(3)-induced vasoconstriction that does not occur as a result of SR Ca(2+) release but because of IP(3) receptor-dependent I(Cat) activation that requires TRPC3 channels.	Inositol 1,4,5-Trisphosphate	45-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	144-158
18289524-0	2008	Agonist-evoked calcium entry in vascular smooth muscle cells requires IP3 receptor-mediated activation of TRPC1.	Calcium	15-22	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-82
18443356-4	2008	IP3, without being an agonist itself, sensitizes TRPV4 to EET in epithelial ciliated cells and cells heterologously expressing TRPV4, an effect inhibited by the IP3 receptor antagonist xestospongin C. Coimmunoprecipitation assays indicated a physical interaction between TRPV4 and IP3 receptor 3.	Inositol 1,4,5-Trisphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	161-173
18443356-4	2008	IP3, without being an agonist itself, sensitizes TRPV4 to EET in epithelial ciliated cells and cells heterologously expressing TRPV4, an effect inhibited by the IP3 receptor antagonist xestospongin C. Coimmunoprecipitation assays indicated a physical interaction between TRPV4 and IP3 receptor 3.	Inositol 1,4,5-Trisphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	281-293
18303017-1	2008	Na,K-ATPase and inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) can form a signaling microdomain that in the presence of ouabain triggers highly regular calcium oscillations.	Ouabain	124-131	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-59
18303017-1	2008	Na,K-ATPase and inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) can form a signaling microdomain that in the presence of ouabain triggers highly regular calcium oscillations.	Ouabain	124-131	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-65
18303017-1	2008	Na,K-ATPase and inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) can form a signaling microdomain that in the presence of ouabain triggers highly regular calcium oscillations.	Calcium	156-163	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-59
18303017-1	2008	Na,K-ATPase and inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) can form a signaling microdomain that in the presence of ouabain triggers highly regular calcium oscillations.	Calcium	156-163	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-65
18203813-6	2008	The initial transient and sustained phases of increased [Ca2+]i were predominantly inhibited by the IP3 receptor antagonist 2-aminoethoxydiphenyl borate (2-APB) or the store-operated Ca2+ channel antagonist SKF-96365, respectively.	2-aminoethoxydiphenyl borate	124-152	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-112
18203813-6	2008	The initial transient and sustained phases of increased [Ca2+]i were predominantly inhibited by the IP3 receptor antagonist 2-aminoethoxydiphenyl borate (2-APB) or the store-operated Ca2+ channel antagonist SKF-96365, respectively.	2-aminoethoxydiphenyl borate	154-159	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-112
18263732-5	2008	Examination of its signaling pathway in HEK293 cells transiently expressing GPR55 found the calcium increase to involve G(q), G(12), RhoA, actin, phospholipase C, and calcium release from IP(3)R-gated stores.	Calcium	92-99	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	188-194
17915188-6	2008	In addition, LPA caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which was inhibited by pretreatment with Ki16425 or 2-aminoethoxy-diphenylborate (2-APB), an inositol 1,4,5-triphosphate (IP(3)) receptor (IP(3)R) blocker.	lysophosphatidic acid	13-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-230
17915188-6	2008	In addition, LPA caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which was inhibited by pretreatment with Ki16425 or 2-aminoethoxy-diphenylborate (2-APB), an inositol 1,4,5-triphosphate (IP(3)) receptor (IP(3)R) blocker.	lysophosphatidic acid	13-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	232-238
17915188-6	2008	In addition, LPA caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which was inhibited by pretreatment with Ki16425 or 2-aminoethoxy-diphenylborate (2-APB), an inositol 1,4,5-triphosphate (IP(3)) receptor (IP(3)R) blocker.	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	134-141	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-230
17915188-6	2008	In addition, LPA caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which was inhibited by pretreatment with Ki16425 or 2-aminoethoxy-diphenylborate (2-APB), an inositol 1,4,5-triphosphate (IP(3)) receptor (IP(3)R) blocker.	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	134-141	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	232-238
17941082-8	2008	Xestospongin C (XeC), which prevents Ca2+ release from intracellular Ca2+ stores by inhibition of inositol 1,4,5-trisphosphate (IP(3)) receptor, inhibited intercellular Ca2+ wave generation and endothelialization following denudation.	xestospongin C	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	128-143
17941082-8	2008	Xestospongin C (XeC), which prevents Ca2+ release from intracellular Ca2+ stores by inhibition of inositol 1,4,5-trisphosphate (IP(3)) receptor, inhibited intercellular Ca2+ wave generation and endothelialization following denudation.	xestospongin C	16-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	128-143
17941082-8	2008	Xestospongin C (XeC), which prevents Ca2+ release from intracellular Ca2+ stores by inhibition of inositol 1,4,5-trisphosphate (IP(3)) receptor, inhibited intercellular Ca2+ wave generation and endothelialization following denudation.	Inositol 1,4,5-Trisphosphate	98-126	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	128-143
18263732-5	2008	Examination of its signaling pathway in HEK293 cells transiently expressing GPR55 found the calcium increase to involve G(q), G(12), RhoA, actin, phospholipase C, and calcium release from IP(3)R-gated stores.	Calcium	167-174	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	188-194
19425119-3	2008	A common channel type present in many cell types is the inositol trisphosphate receptor (IP(3)R), which is activated by IP(3) and Ca(2+) itself leading to Ca(2+) induced Ca(2+) release (CICR).	cicr	186-190	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-95
18171931-2	2008	Here we show that the cerebellar inositol-1,4,5-trisphosphate (IP3) receptor, whose activation is required for LTD induction, is sensitive in situ to the order of presentation of its coagonists, IP3 and cytoplasmic calcium.	Calcium	215-222	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-76
18171931-5	2008	IP3 receptor binding thus acts as an eligibility trace that can drive temporal order-dependent calcium release and LTD induction in Purkinje cells and event order-dependent sensory plasticity in the whole animal.	Calcium	95-102	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-12
18158870-6	2008	Interestingly, the inclusion of inositol 1,4,5 trisphosphate (IP3; 100 micromol/L) in the patch pipette rendered the OAG-induced current susceptible to the persistent Ca2+-mediated inhibition independent of the IP3 receptor in the majority of the tested cells, as evidenced by the inability of heparin and thapsigargin in reversing the effect of IP3.	Inositol 1,4,5-Trisphosphate	32-60	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	211-223
18158870-6	2008	Interestingly, the inclusion of inositol 1,4,5 trisphosphate (IP3; 100 micromol/L) in the patch pipette rendered the OAG-induced current susceptible to the persistent Ca2+-mediated inhibition independent of the IP3 receptor in the majority of the tested cells, as evidenced by the inability of heparin and thapsigargin in reversing the effect of IP3.	Inositol 1,4,5-Trisphosphate	62-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	211-223
18158870-6	2008	Interestingly, the inclusion of inositol 1,4,5 trisphosphate (IP3; 100 micromol/L) in the patch pipette rendered the OAG-induced current susceptible to the persistent Ca2+-mediated inhibition independent of the IP3 receptor in the majority of the tested cells, as evidenced by the inability of heparin and thapsigargin in reversing the effect of IP3.	1-oleoyl-2-acetylglycerol	117-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	211-223
17646931-6	2007	Further investigation lead us to the novel discovery that 4OHT-induced increase of ATP-dependent Ca2+ release from the endoplasmic reticulum correlated with 4OHT-induced upregulation of protein phosphatase 1alpha (PP1alpha) and the inositol 1,4,5-trisphosphate receptor (IP3R).	4,17 beta-dihydroxy-4-androstene-3-one	58-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	271-275
17670901-7	2007	The effects of ouabain-mediated increases in IP3 production or IP3R conductance on [Ca2+](cyt) depend on their relative distributions between cellular microdomains and the bulk cytoplasm.	Ouabain	15-22	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
17592515-0	2007	IP(3) receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+-influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis.	2-aminoethoxydiphenyl borate	27-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-14
17761776-4	2007	In permeabilized myocytes IP(3) (20 microm) and the more potent IP(3)R agonist adenophostin (5 microm) caused an elevation of [Ca(2+)](Nuc).	adenophostin A	79-91	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	64-70
17761776-5	2007	An IP(3)-dependent increase of [Ca(2+)](Nuc) was still observed after pretreatment with tetracaine to block Ca(2+) release from ryanodine receptors (RyRs), and the effect of IP(3) was partially reversed or prevented by the IP(3)R blockers heparin and 2-APB.	Inositol 1,4,5-Trisphosphate	3-8	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	223-229
17761776-5	2007	An IP(3)-dependent increase of [Ca(2+)](Nuc) was still observed after pretreatment with tetracaine to block Ca(2+) release from ryanodine receptors (RyRs), and the effect of IP(3) was partially reversed or prevented by the IP(3)R blockers heparin and 2-APB.	Tetracaine	88-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	223-229
17761776-12	2007	Stimulation of IP(3)R caused depletion of the nuclear Ca(2+) stores by approximately 60% relative to the maximum depletion produced by the ionophores ionomycin and A23187.	Ionomycin	150-159	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	15-21
17761776-12	2007	Stimulation of IP(3)R caused depletion of the nuclear Ca(2+) stores by approximately 60% relative to the maximum depletion produced by the ionophores ionomycin and A23187.	Calcimycin	164-170	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	15-21
17951979-6	2007	U-73122 (1 microM), a PLC inhibitor, and xestospongin C (2 microM), an IP(3)-receptor antagonist, elicited 11.5 +/- 2.9% and 17.8 +/- 1.9% suppressions, respectively.	xestospongin C	41-55	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-85
17720133-6	2007	ATP-induced activation of MAPKs was diminished by two PI-PLC inhibitors and an IP(3) receptor antagonist.	Adenosine Triphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-93
17592515-0	2007	IP(3) receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+-influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis.	Cisplatin	45-54	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-14
17592515-9	2007	This elevation of [Ca(2+)](i) depended on extracellular Ca(2+) but was reduced by the IP(3) receptor blocker, 2-APB.	2-aminoethoxydiphenyl borate	110-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-100
17215326-0	2007	NF-kappaB activation by depolarization of skeletal muscle cells depends on ryanodine and IP3 receptor-mediated calcium signals.	Calcium	111-118	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-101
17404493-1	2007	The second messenger myo-inositol-1,4,5-trisphosphate (IP(3)) acts on the IP(3) receptor (IP(3)R), an IP(3)-activated Ca(2+) channel of the endoplasmic reticulum (ER).	Inositol 1,4,5-Trisphosphate	21-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-88
17404493-1	2007	The second messenger myo-inositol-1,4,5-trisphosphate (IP(3)) acts on the IP(3) receptor (IP(3)R), an IP(3)-activated Ca(2+) channel of the endoplasmic reticulum (ER).	Inositol 1,4,5-Trisphosphate	21-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-96
17404493-1	2007	The second messenger myo-inositol-1,4,5-trisphosphate (IP(3)) acts on the IP(3) receptor (IP(3)R), an IP(3)-activated Ca(2+) channel of the endoplasmic reticulum (ER).	ip	55-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-88
17404493-1	2007	The second messenger myo-inositol-1,4,5-trisphosphate (IP(3)) acts on the IP(3) receptor (IP(3)R), an IP(3)-activated Ca(2+) channel of the endoplasmic reticulum (ER).	ip	55-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-96
17404493-3	2007	The IP(3)R antagonist xestospongin B induces autophagy in human cells through a pathway that requires the obligate contribution of Beclin-1, Atg5, Atg10, Atg12 and hVps34, yet is inhibited by ER-targeted Bcl-2 or Bcl-XL, two proteins that physically interact with IP(3)R.	xestospongin B	22-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-10
17404493-3	2007	The IP(3)R antagonist xestospongin B induces autophagy in human cells through a pathway that requires the obligate contribution of Beclin-1, Atg5, Atg10, Atg12 and hVps34, yet is inhibited by ER-targeted Bcl-2 or Bcl-XL, two proteins that physically interact with IP(3)R.	xestospongin B	22-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	264-270
17395173-7	2007	The direct intracellular IP3 receptor antagonist xestospongin C (10 microM) reduced carbachol-stimulated intracellular Ca2+ to 41% of the control value.	xestospongin C	49-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	25-37
17395173-7	2007	The direct intracellular IP3 receptor antagonist xestospongin C (10 microM) reduced carbachol-stimulated intracellular Ca2+ to 41% of the control value.	Carbachol	84-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	25-37
17567812-4	2007	P2Y-R enhanced neuroprotection was blocked by oligomycin and by Xestospongin C, inhibitors of the ATP synthase and of inositol (1,4,5) triphosphate (IP3) binding to the IP3 receptor, respectively.	p2y-r	0-5	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	169-181
17567812-4	2007	P2Y-R enhanced neuroprotection was blocked by oligomycin and by Xestospongin C, inhibitors of the ATP synthase and of inositol (1,4,5) triphosphate (IP3) binding to the IP3 receptor, respectively.	xestospongin C	64-78	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	169-181
17567812-4	2007	P2Y-R enhanced neuroprotection was blocked by oligomycin and by Xestospongin C, inhibitors of the ATP synthase and of inositol (1,4,5) triphosphate (IP3) binding to the IP3 receptor, respectively.	Inositol 1,4,5-Trisphosphate	118-147	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	169-181
17460090-7	2007	These opposing effects on Ca2+ signals were both mediated by an increase in intracellular inositol 1,4,5-trisphosphate (IP3) levels, because they were blocked by heparin, an IP3 receptor antagonist, and reproduced by photolytic application of IP3.	1,4,5-trisphosphate	99-118	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	174-186
17460090-7	2007	These opposing effects on Ca2+ signals were both mediated by an increase in intracellular inositol 1,4,5-trisphosphate (IP3) levels, because they were blocked by heparin, an IP3 receptor antagonist, and reproduced by photolytic application of IP3.	Inositol 1,4,5-Trisphosphate	120-123	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	174-186
17460090-7	2007	These opposing effects on Ca2+ signals were both mediated by an increase in intracellular inositol 1,4,5-trisphosphate (IP3) levels, because they were blocked by heparin, an IP3 receptor antagonist, and reproduced by photolytic application of IP3.	Heparin	162-169	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	174-186
17341135-0	2007	Expanding the neuron"s calcium signaling repertoire: intracellular calcium release via voltage-induced PLC and IP3R activation.	Calcium	23-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-115
17395556-4	2007	The IP3R loop is an important part of the channel"s pore-forming region, and the chromogranin peptide has been shown to competitively inhibit calcium signaling by IP3R.	Calcium	142-149	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	163-167
17395556-1	2007	The inositol 1,4,5-trisphosphate receptor (IP3R) is a membrane channel that conducts calcium ions from the intracellular calcium stores.	Calcium	85-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	43-47
17395556-1	2007	The inositol 1,4,5-trisphosphate receptor (IP3R) is a membrane channel that conducts calcium ions from the intracellular calcium stores.	Calcium	121-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	43-47
17395556-4	2007	The IP3R loop is an important part of the channel"s pore-forming region, and the chromogranin peptide has been shown to competitively inhibit calcium signaling by IP3R.	Calcium	142-149	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-8
17341135-0	2007	Expanding the neuron"s calcium signaling repertoire: intracellular calcium release via voltage-induced PLC and IP3R activation.	Calcium	67-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-115
17241155-0	2007	Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release.	Alcohols	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	102-106
17262224-4	2007	When the stochastic opening and closing of IP(3)R channels are considered, it is shown that the membrane potential oscillation transfers from spiking to bursting with the channel number decreasing, and the average cytosolic free Ca(2+) concentration is increased with the increase of glucose concentration.	Glucose	284-291	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	43-49
17264956-8	2007	Thrombin-induced t-PA release was limited by a membrane-permeable Galphaq inhibitory peptide, the PLC-beta antagonist U73122, and the IP3 receptor antagonist 2-aminoethoxyphenylborane, while the Galphaq agonist Pasteurella toxin modestly induced t-PA release.	2-aminoethoxyphenylborane	158-183	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	134-146
16885398-2	2007	Inhibition of Ca(2+) mobilization by cAMP- (PKA) and cGMP-dependent (PKG) protein kinases reflects inhibition of PI hydrolysis by both kinases and PKG-specific inhibitory phosphorylation of IP(3) receptor type I.	Cyclic GMP	53-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	190-204
17241155-0	2007	Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release.	Calcium	128-135	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	102-106
17241155-5	2007	We proposed that EtOH metabolites stimulated inositol 1,4,5-triphosphate receptor (IP(3)R)-operated intracellular calcium (Ca(2+)) release, thereby causing the activation of MLCK in BMVEC.	Ethanol	17-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	83-89
17241155-5	2007	We proposed that EtOH metabolites stimulated inositol 1,4,5-triphosphate receptor (IP(3)R)-operated intracellular calcium (Ca(2+)) release, thereby causing the activation of MLCK in BMVEC.	Calcium	114-121	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	83-89
17241155-6	2007	Indeed, treatment of primary human BMVEC with EtOH or its metabolites resulted in the increased expression of IP(3)R protein and IP(3)R-gated intracellular Ca(2+) release.	Ethanol	46-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-116
17241155-6	2007	Indeed, treatment of primary human BMVEC with EtOH or its metabolites resulted in the increased expression of IP(3)R protein and IP(3)R-gated intracellular Ca(2+) release.	Ethanol	46-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-135
17241155-9	2007	These findings suggest that EtOH metabolites act as signaling molecules for the activation of MLCK via the stimulation of IP(3)R-gated intracellular Ca(2+) release in BMVEC.	Ethanol	28-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-128
16460762-6	2006	The model incorporates ATP-mediated IP3 production, the subsequent Ca2+ release from the ER through IP3R channels and ATP release into the extracellular space.	Adenosine Triphosphate	23-26	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-104
17031847-10	2006	The plasma membrane IP(3) receptor (IP(3)R) plays an essential role in Ca2+ influx, by interacting with the DAG-activated TRPC, without the requirement of binding to IP(3).	Diglycerides	108-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-34
17031847-10	2006	The plasma membrane IP(3) receptor (IP(3)R) plays an essential role in Ca2+ influx, by interacting with the DAG-activated TRPC, without the requirement of binding to IP(3).	Diglycerides	108-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	36-42
17130290-3	2006	We show that Fas-mediated apoptosis requires endoplasmic reticulum-mediated calcium release in a mechanism dependent on phospholipase C-gamma1 (PLC-gamma1) activation and Ca2+ release from inositol 1,4,5-trisphosphate receptor (IP3R) channels.	ammonium ferrous sulfate	13-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	228-232
17130290-3	2006	We show that Fas-mediated apoptosis requires endoplasmic reticulum-mediated calcium release in a mechanism dependent on phospholipase C-gamma1 (PLC-gamma1) activation and Ca2+ release from inositol 1,4,5-trisphosphate receptor (IP3R) channels.	Calcium	76-83	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	228-232
17130674-5	2006	2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP.	2-aminoethoxydiphenylborane	7-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-87
17130674-5	2006	2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP.	Uridine Triphosphate	110-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-87
16974067-4	2006	The increase that occurred during the administration partially remained in the Ca(2+)-free medium and was blocked by 2-aminoethoxydiphenyl borate (2-APB), an IP(3)-receptor blocker, indicating that the source of Ca(2+) for the increase could be ascribed to the intracellular store.	2-aminoethoxydiphenyl borate	117-145	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	158-172
17132820-1	2006	In both nonexcitable and excitable cells, the inositol 1,4,5-trisphosphate receptor (IP(3)R) is the primary cytosolic target responsible for the initiation of intracellular calcium (Ca(2+)) signaling.	Calcium	173-180	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-91
16533496-14	2006	Taken together, these observations highlight the importance of ATP as a co-neurotransmitter at the neuromuscular junction via dual signalling, i.e. IP3 receptor mediated Ca2+ transients and Ca2+ insensitive phosphorylation of ERK1/2.	Adenosine Triphosphate	63-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	148-160
16793548-0	2006	IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor.	Inositol 1,4,5-Trisphosphate	17-20	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-108
16793548-2	2006	We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence of IP3.	Inositol 1,4,5-Trisphosphate	28-31	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-102
16793548-2	2006	We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence of IP3.	Inositol 1,4,5-Trisphosphate	28-31	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-102
16793548-2	2006	We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence of IP3.	Inositol 1,4,5-Trisphosphate	76-79	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-32
16793548-2	2006	We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence of IP3.	Inositol 1,4,5-Trisphosphate	76-79	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-102
16793548-2	2006	We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence of IP3.	Inositol 1,4,5-Trisphosphate	76-79	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-102
16793548-3	2006	In the present study, we showed that IRBIT suppresses the activation of IP3R by competing with IP3 by [3H]IP3 binding assays, in vitro Ca2+ release assays, and Ca2+ imaging of intact cells.	Tritium	103-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-76
16793548-3	2006	In the present study, we showed that IRBIT suppresses the activation of IP3R by competing with IP3 by [3H]IP3 binding assays, in vitro Ca2+ release assays, and Ca2+ imaging of intact cells.	Inositol 1,4,5-Trisphosphate	95-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-76
16793548-4	2006	Multiserine phosphorylation of IRBIT was essential for the binding, and 10 of the 12 key amino acids in IP3R for IP3 recognition participated in binding to IRBIT.	multiserine	0-11	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	104-108
16899571-5	2006	When 2-aminoethoxydiphenyl borate (2APB) (an inhibitor of the inosital 1,4,5-trisphosphate receptor (IP3R) and possibly SOC) was used in conjunction with ATP, it was capable of completely inhibiting CCE.	2-aminoethoxydiphenyl borate	5-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-105
16899571-5	2006	When 2-aminoethoxydiphenyl borate (2APB) (an inhibitor of the inosital 1,4,5-trisphosphate receptor (IP3R) and possibly SOC) was used in conjunction with ATP, it was capable of completely inhibiting CCE.	Carbamylcholine	199-202	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-105
16500959-1	2006	Hormones that act through the calcium-releasing messenger, inositol 1,4,5-trisphosphate (IP3), cause intracellular calcium oscillations, which have been ascribed to calcium feedbacks on the IP3 receptor.	Inositol 1,4,5-Trisphosphate	59-87	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	190-202
16500959-1	2006	Hormones that act through the calcium-releasing messenger, inositol 1,4,5-trisphosphate (IP3), cause intracellular calcium oscillations, which have been ascribed to calcium feedbacks on the IP3 receptor.	Inositol 1,4,5-Trisphosphate	89-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	190-202
16500959-1	2006	Hormones that act through the calcium-releasing messenger, inositol 1,4,5-trisphosphate (IP3), cause intracellular calcium oscillations, which have been ascribed to calcium feedbacks on the IP3 receptor.	Calcium	30-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	190-202
16500959-1	2006	Hormones that act through the calcium-releasing messenger, inositol 1,4,5-trisphosphate (IP3), cause intracellular calcium oscillations, which have been ascribed to calcium feedbacks on the IP3 receptor.	Calcium	115-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	190-202
16554048-3	2006	We employed a norepinephrine uptake assay using SH-SY5Y cells and found that the IP3 receptor inhibitors, 2-aminoethoxydiphenyl borate and xestospongin C, reduced the NET Vmax.	Norepinephrine	14-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-93
16527252-1	2006	IRBIT has previously been shown to interact with the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) in an IP3-sensitive way.	Inositol 1,4,5-Trisphosphate	83-86	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-102
16527252-3	2006	We now show that IRBIT can directly interact with the IP3R, and that both the suppressor domain and the IP3-binding core of the IP3R are essential for a strong interaction.	Inositol 1,4,5-Trisphosphate	54-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	128-132
16527252-6	2006	Finally, we demonstrated that this interaction functionally affects the IP3R: IRBIT inhibits both IP3 binding and IP3-induced Ca2+ release.	Inositol 1,4,5-Trisphosphate	98-101	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-76
16554048-3	2006	We employed a norepinephrine uptake assay using SH-SY5Y cells and found that the IP3 receptor inhibitors, 2-aminoethoxydiphenyl borate and xestospongin C, reduced the NET Vmax.	2-aminoethoxydiphenyl borate	106-134	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-93
16554048-3	2006	We employed a norepinephrine uptake assay using SH-SY5Y cells and found that the IP3 receptor inhibitors, 2-aminoethoxydiphenyl borate and xestospongin C, reduced the NET Vmax.	xestospongin C	139-153	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-93
16562915-1	2006	[structure: see text] 5"-Deoxy-5"-phenyladenophostin A (5), designed as a useful IP(3) receptor ligand based on the previous structure-activity relationship studies, was successfully synthesized via two key stereoselective glycosidation steps.	5'-deoxy-5'-phenyladenophostin A	22-54	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-95
16623834-4	2006	The drug 2-aminoethoxydiphenyl borate (2APB), an IP3 receptor inhibitor, produced a marked decrease of mEPSP and spike frequency at low concentration (0.1 mm), without affecting mEPSP size or time course.	2-aminoethoxydiphenyl borate	9-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-61
16539376-7	2006	The alpha-C2-glucoside trisphosphate 8 stimulates Ca2+ release with a potency similar to that of IP3 in spite of its simplified structure, indicating a better fit to the receptor than the beta-C-glucoside trisphosphates and also the alpha-congeners having a shorter or longer C1 side chain, which was supported by molecular modeling using the ligand binding domain of the IP3 receptor.	alpha-c2-glucoside trisphosphate	4-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	372-384
16249374-2	2006	Xestospongin C (XeC) was shown to selectively block IP(3)-induced Ca(2+) release and IP(3)R-mediated signaling (Gafni et al., 1997).	xestospongin C	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-91
16445278-5	2006	Addition of heparin or IP(3)R antibody blocked the IP(3)-induced Ca(2+) releases, indicating the release of Ca(2+) through the IP(3)R/Ca(2+) channels.	Heparin	12-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	127-133
16446505-6	2006	Upon incubation with pertussis toxin (PTX), an inhibitory effect similar to that of the IP3R inhibitor (2-APB) was observed on K+-evoked calcium release.	Calcium	137-144	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	88-92
16485066-11	2006	2-APB (IP3R blocker) reduced the basal DNA synthesis to 51.3% +/- 8.4% but had no effect on either IGF.	2-aminoethoxydiphenyl borate	0-5	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	7-11
16289054-4	2006	We find that the zero-magnesium-induced synchronized activity is blocked by inhibition of sarco-endoplasmic reticulum Ca(2+)-ATPases, phospholipase C (PLC), the inositol 1,4,5-trisphosphate (IP3) receptor, and the ryanodine receptor.	Magnesium	22-31	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	191-204
16249374-2	2006	Xestospongin C (XeC) was shown to selectively block IP(3)-induced Ca(2+) release and IP(3)R-mediated signaling (Gafni et al., 1997).	xestospongin C	16-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-91
16249374-8	2006	A new finding is that XeD and related structures possessing a hydroxylated oxaquinolizidine ring are IP(3)R blockers that also enhance Ca(2+)-induced Ca(2+) release mediated by RyRs.	hexahydro-2H,6H-pyrido[2,1-b][1,3]oxazine	75-91	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-107
16173918-1	2006	The IP3R (inositol 1,4,5-trisphosphate receptor) Ca2+-release channel is known to be sensitive to thiol redox state.	Sulfhydryl Compounds	98-103	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-69
16173918-2	2006	The present study was undertaken to characterize the number and location of reactive thiol groups in the type-I IP3R.	Sulfhydryl Compounds	85-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-116
16173918-4	2006	70% of the 60 cysteine residues in the type-I IP3R are maintained in the reduced state.	Cysteine	14-22	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-50
16173918-5	2006	The accessibility of these residues was assessed by covalently tagging the IP3R in membranes with a 5 kDa or 20 kDa MPEG [methoxypoly(ethylene glycol) maleimide].	methyl cellosolve	116-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	75-79
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	methyl cellosolve	0-4	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	methyl cellosolve	0-4	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	246-250
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Sodium Dodecyl Sulfate	56-59	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Sodium Dodecyl Sulfate	56-59	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	246-250
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Dithiothreitol	120-134	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Dithiothreitol	120-134	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	246-250
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Ethylmaleimide	136-152	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Ethylmaleimide	136-152	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	246-250
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Mersalyl	154-162	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Mersalyl	154-162	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	246-250
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Thimerosal	166-176	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Thimerosal	166-176	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	246-250
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	methyl cellosolve	194-198	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	methyl cellosolve	194-198	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	246-250
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Sulfhydryl Compounds	226-231	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Sulfhydryl Compounds	226-231	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	246-250
16173918-13	2006	We conclude that a set of highly reactive cysteine residues in fragment I are differentially accessible in the SI(+) and SI(-) splice variants of the type-I IP3R.	Cysteine	42-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	157-161
16226241-5	2005	These results demonstrate that differentiated skeletal myotubes employ discrete pools of intracellular calcium to restrain (IP3R pool) or activate (RYR pool) NFAT-dependent signaling, in a manner distinct from undifferentiated myoblasts.	Calcium	103-110	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	124-128
16474998-0	2006	Effects of magnesium sulfate administration during hypoxia on Ca(2+) influx and IP(3) receptor modification in cerebral cortical neuronal nuclei of newborn piglets.	Magnesium Sulfate	11-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-94
16474998-10	2006	In addition results show that magnesium prevented hypoxia-induced modification of the IP(3) receptor.	Magnesium	30-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-100
16474998-12	2006	The results demonstrate that the administration of magnesium sulfate prior to hypoxia prevents the hypoxia-induced increase in intranuclear Ca(2+) and IP(3) receptor modifications.	Magnesium Sulfate	51-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	151-165
15947791-5	2005	We demonstrate that the predominate mechanism underlying caspase and Bax-mediated adult neural stem cell death lies in the modulation of calcium flux through interaction with the IP3 receptor.	Calcium	137-144	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	179-191
16897576-5	2006	A slow component of calcium release dependent on IP3R, as well as the production of IP3, were also reduced to normal levels by expression of mini-dystrophin.	Calcium	20-27	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
16169982-2	2005	It is found that the unusually high density and low sensitivity of inositol-1,4,5-trisphosphate receptors (IP3R) are critical to the ability of the cell to generate and localize a calcium spike in a single dendritic spine.	Calcium	180-187	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-111
16169982-5	2005	The sensitivity of calcium release rates from the IP3R to calcium concentrations, as well as IP3 concentrations, allows the calcium spike to form.	Calcium	19-26	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
16169982-5	2005	The sensitivity of calcium release rates from the IP3R to calcium concentrations, as well as IP3 concentrations, allows the calcium spike to form.	Calcium	58-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
16169982-5	2005	The sensitivity of calcium release rates from the IP3R to calcium concentrations, as well as IP3 concentrations, allows the calcium spike to form.	Calcium	58-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
16175570-5	2005	Xestospongin C (XeC), an antagonist of the inositol-3-phosphate (IP(3)) receptor (IP(3)R) also prevents neuronal damage.	xestospongin C	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-80
16266433-6	2005	Activation caused a biphasic increase in intracellular [Ca2+] that could be partially blocked by 2-aminoethoxy-diphenyl borate (2-APB), an inhibitor of the IP3 receptor and store-operated channels.	2-aminoethoxydiphenyl borate	97-126	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-168
16266433-6	2005	Activation caused a biphasic increase in intracellular [Ca2+] that could be partially blocked by 2-aminoethoxy-diphenyl borate (2-APB), an inhibitor of the IP3 receptor and store-operated channels.	2-aminoethoxydiphenyl borate	128-133	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-168
16291968-6	2005	Indirect immunofluorescence clearly detected both inositol 1,4,5-trisphosphate (IP(3)) receptor and calreticulin in the connecting piece, indicating the presence of internal calcium store.	Calcium	174-181	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-95
16175570-5	2005	Xestospongin C (XeC), an antagonist of the inositol-3-phosphate (IP(3)) receptor (IP(3)R) also prevents neuronal damage.	xestospongin C	16-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-80
16175570-5	2005	Xestospongin C (XeC), an antagonist of the inositol-3-phosphate (IP(3)) receptor (IP(3)R) also prevents neuronal damage.	inositol 3-phosphate	43-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-80
15767306-12	2005	The combination of the IP(3)R antagonists, 2-APB or TMB-8, with DPI or TEMPOL further reduced the response by 83%.	3-aminodiphenyleneiodium	64-67	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	23-29
15857686-6	2005	Postsynaptic perfusion of the IP(3)R agonist adenophostin (AdA) during subthreshold stimulation appeared to convert silent to active synapses; synaptic transmission at these active synapses was completely blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX).	6-Cyano-7-nitroquinoxaline-2,3-dione	254-258	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-36
15755493-1	2005	We focused our attention on Ca(2+) release from the endoplasmic reticulum through a cluster of inositol(1,4,5)-trisphosphate (IP(3)) receptor channels.	Inositol 1,4,5-Trisphosphate	95-124	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-141
15748704-1	2005	Effect of unfractionated heparin (UFH), described as a cell-impermeant IP3 receptor antagonist, was studied on the capacitive Ca(2+) entry in non-permeabilized, intact cells, measuring the intracellular Ca(2+) levels using fluorescence microplate technique.	Heparin	34-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-83
15767306-3	2005	IP(3)R-mediated release of SR Ca(2+) causes calcium-induced calcium release (CICR) via the ryanodine receptor (RyR), which can be sensitized by cyclic adeninediphosphate ribose (cADPR).	Calcium	44-51	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-6
15767306-3	2005	IP(3)R-mediated release of SR Ca(2+) causes calcium-induced calcium release (CICR) via the ryanodine receptor (RyR), which can be sensitized by cyclic adeninediphosphate ribose (cADPR).	Calcium	60-67	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-6
15942047-8	2005	IP3 receptor blockade by 10 microM TMB-8 (n = 6) reduced the peak to 22 +/- 8 and prevented the sustained response.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	35-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-12
15880446-5	2005	It was interestingly found that the higher activity of selenoproteins reduced the sensitivity of IP3 receptor to the IP3-triggered Ca2+ release from intracellular stores, but enhanced activation of the receptor-coupled phospholipase C in histamine-stimulated Se+ cells by showing much more generation of IP3 and higher elevation of cytosolic Ca2+.	Inositol 1,4,5-Trisphosphate	117-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	97-109
15814613-3	2005	Embryonic fibroblasts lacking the transactivating subunit of NF-kappaB RelA (p65) exhibit enhanced inositol 1,4,5-trisphosphate (IP(3)) receptor-mediated calcium release and increased sensitivity to apoptosis, which are restored upon re-expression of RelA.	Inositol 1,4,5-Trisphosphate	99-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-144
15814613-3	2005	Embryonic fibroblasts lacking the transactivating subunit of NF-kappaB RelA (p65) exhibit enhanced inositol 1,4,5-trisphosphate (IP(3)) receptor-mediated calcium release and increased sensitivity to apoptosis, which are restored upon re-expression of RelA.	Calcium	154-161	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	129-144
15911776-5	2005	Here, we use the expression of IP(3) binding protein domains tethered to the surface of the endoplasmic reticulum (ER) to show that the all-helical domain of the IP(3)R LBD is capable of depleting the ER Ca(2+) pools by opening the endogenous IP(3)Rs, even without IP(3) binding.	ip	31-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	162-168
15857686-6	2005	Postsynaptic perfusion of the IP(3)R agonist adenophostin (AdA) during subthreshold stimulation appeared to convert silent to active synapses; synaptic transmission at these active synapses was completely blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX).	adenophostin A	45-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-36
15857686-6	2005	Postsynaptic perfusion of the IP(3)R agonist adenophostin (AdA) during subthreshold stimulation appeared to convert silent to active synapses; synaptic transmission at these active synapses was completely blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX).	6-Cyano-7-nitroquinoxaline-2,3-dione	216-252	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-36
15767306-3	2005	IP(3)R-mediated release of SR Ca(2+) causes calcium-induced calcium release (CICR) via the ryanodine receptor (RyR), which can be sensitized by cyclic adeninediphosphate ribose (cADPR).	cicr	77-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-6
15665074-1	2005	Apoptotic stimuli augment intracellular calcium concentration through inositol 1,4,5-trisphosphate receptors (IP3R) on endoplasmic reticulum calcium stores.	Calcium	40-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
15767306-3	2005	IP(3)R-mediated release of SR Ca(2+) causes calcium-induced calcium release (CICR) via the ryanodine receptor (RyR), which can be sensitized by cyclic adeninediphosphate ribose (cADPR).	cyclic adeninediphosphate ribose	144-176	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-6
15767306-3	2005	IP(3)R-mediated release of SR Ca(2+) causes calcium-induced calcium release (CICR) via the ryanodine receptor (RyR), which can be sensitized by cyclic adeninediphosphate ribose (cADPR).	Cyclic ADP-Ribose	178-183	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-6
15665074-1	2005	Apoptotic stimuli augment intracellular calcium concentration through inositol 1,4,5-trisphosphate receptors (IP3R) on endoplasmic reticulum calcium stores.	Calcium	141-148	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
15677321-1	2005	NADH regulates the release of calcium from the endoplasmic reticulum by modulation of inositol 1,4,5-trisphosphate receptors (IP3R), accounting for the augmented calcium release of hypoxic cells.	Calcium	162-169	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-130
15677321-2	2005	We report selective binding of IP3R to GAPDH, whose activity leads to the local generation of NADH to regulate intracellular calcium signaling.	NAD	94-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	31-35
15677321-2	2005	We report selective binding of IP3R to GAPDH, whose activity leads to the local generation of NADH to regulate intracellular calcium signaling.	Calcium	125-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	31-35
15677321-3	2005	This interaction requires cysteines 992 and 995 of IP3R and C150 of GAPDH.	Cysteine	26-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	51-55
15677321-4	2005	Addition of native GAPDH and NAD+ to WT IP3R stimulates calcium release, whereas no stimulation occurs with C992S/995S IP3R that cannot bind GAPDH.	NAD	29-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-44
15677321-4	2005	Addition of native GAPDH and NAD+ to WT IP3R stimulates calcium release, whereas no stimulation occurs with C992S/995S IP3R that cannot bind GAPDH.	Calcium	56-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-44
15677321-5	2005	Thus, the IP3R/GAPDH interaction likely enables cellular energy dynamics to impact calcium signaling.	Calcium	83-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	10-14
15677321-1	2005	NADH regulates the release of calcium from the endoplasmic reticulum by modulation of inositol 1,4,5-trisphosphate receptors (IP3R), accounting for the augmented calcium release of hypoxic cells.	NAD	0-4	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-130
15677321-1	2005	NADH regulates the release of calcium from the endoplasmic reticulum by modulation of inositol 1,4,5-trisphosphate receptors (IP3R), accounting for the augmented calcium release of hypoxic cells.	Calcium	30-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-130
15665074-2	2005	We previously discovered an apoptotic cascade wherein cytochrome c binds to IP3R early in apoptosis, resulting in dysregulated calcium release.	Calcium	127-134	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-80
15665074-3	2005	Here we show that cytochrome c binding to IP3R depends on a cluster of glutamic acid residues within the C terminus of the channel.	Glutamic Acid	71-84	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-46
15665074-4	2005	A cell permeant peptide derived from this sequence displaces cytochrome c from IP3R and abrogates cell death induced by staurosporine treatment of HeLa cells and Fas ligand stimulation of Jurkat cells.	Staurosporine	120-133	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-83
15556942-9	2005	IL8 treatment resulted in the increase of cGMP level that was inhibited by the IP(3) receptor blocker but not a protein kinase C inhibitor.	Cyclic GMP	42-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-93
16245207-6	2005	TMB-8, inhibitor of IP3 receptor decreased PARP-1 activation evoked by carbachol/GTP(g)S. Stimulation of mChR did not lead to free radicals generation but activate PARP-1 through IP3/Ca2+ regulated processes.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	0-5	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-32
16245207-6	2005	TMB-8, inhibitor of IP3 receptor decreased PARP-1 activation evoked by carbachol/GTP(g)S. Stimulation of mChR did not lead to free radicals generation but activate PARP-1 through IP3/Ca2+ regulated processes.	Carbachol	71-80	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-32
16245207-6	2005	TMB-8, inhibitor of IP3 receptor decreased PARP-1 activation evoked by carbachol/GTP(g)S. Stimulation of mChR did not lead to free radicals generation but activate PARP-1 through IP3/Ca2+ regulated processes.	Guanosine Triphosphate	81-84	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-32
15604462-1	2005	We show that activation of postsynaptic inositol 1,4,5-tris-phosphate receptors (IP(3)Rs) with the IP(3)R agonist adenophostin A (AdA) produces large increases in AMPA receptor (AMPAR) excitatory postsynaptic current (EPSC) amplitudes at hippocampal CA1 synapses.	adenophostin A	114-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-87
15604462-1	2005	We show that activation of postsynaptic inositol 1,4,5-tris-phosphate receptors (IP(3)Rs) with the IP(3)R agonist adenophostin A (AdA) produces large increases in AMPA receptor (AMPAR) excitatory postsynaptic current (EPSC) amplitudes at hippocampal CA1 synapses.	adenophostin A	130-133	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-87
15316011-10	2004	Therefore, the cell-permeable IP(3)R antagonist 2-aminoethoxydiphenyl borate blocked the cAMP-promoted CICR.	2-aminoethoxydiphenyl borate	48-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-36
15829109-5	2005	This release can be completely blocked by heparin, a well-known antagonist of IP3 receptor, indicating a direct activation of IP3 receptor on endoplasmic reticulum (ER) membrane by H2O2.	Heparin	42-49	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-90
15829109-5	2005	This release can be completely blocked by heparin, a well-known antagonist of IP3 receptor, indicating a direct activation of IP3 receptor on endoplasmic reticulum (ER) membrane by H2O2.	Heparin	42-49	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-138
15829109-5	2005	This release can be completely blocked by heparin, a well-known antagonist of IP3 receptor, indicating a direct activation of IP3 receptor on endoplasmic reticulum (ER) membrane by H2O2.	Hydrogen Peroxide	181-185	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-90
15829109-5	2005	This release can be completely blocked by heparin, a well-known antagonist of IP3 receptor, indicating a direct activation of IP3 receptor on endoplasmic reticulum (ER) membrane by H2O2.	Hydrogen Peroxide	181-185	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-138
15558242-7	2004	This response was slightly attenuated by 2-aminoethyldiphenyl borate (2-APB), a D: -myo-inositol 1,4,5-trisphosphate (IP(3)) receptor blocker, and by genistein, a general tyrosine kinase inhibitor.	Inositol 1,4,5-Trisphosphate	80-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	118-133
15316011-10	2004	Therefore, the cell-permeable IP(3)R antagonist 2-aminoethoxydiphenyl borate blocked the cAMP-promoted CICR.	Cyclic AMP	89-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-36
15316011-10	2004	Therefore, the cell-permeable IP(3)R antagonist 2-aminoethoxydiphenyl borate blocked the cAMP-promoted CICR.	cicr	103-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-36
15326217-5	2004	To investigate the participation of the inositol trisphosphate (IP(3)) receptors (IP(3)R), we utilized two inhibitors of the mammalian IP(3)R, TMB-8 and 2-APB.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	143-148	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-88
15175223-1	2004	An increase in intracellular free Ca(2+) concentration ([Ca(2+)](i)) has been shown to be involved in the increase in ciliary beat frequency (CBF) in response to ATP; however, the signaling pathways associated with inositol 1,4,5-trisphosphate (IP(3)) receptor-dependent Ca(2+) mobilization remain unresolved.	Adenosine Triphosphate	162-165	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	245-260
15175223-1	2004	An increase in intracellular free Ca(2+) concentration ([Ca(2+)](i)) has been shown to be involved in the increase in ciliary beat frequency (CBF) in response to ATP; however, the signaling pathways associated with inositol 1,4,5-trisphosphate (IP(3)) receptor-dependent Ca(2+) mobilization remain unresolved.	Inositol 1,4,5-Trisphosphate	215-243	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	245-260
15175223-5	2004	Xestospongin C, an IP(3) receptor blocker, significantly diminished both the ATP-induced increase in CBF and the initial transient [Ca(2+)](i) component.	xestospongin C	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-33
15175223-5	2004	Xestospongin C, an IP(3) receptor blocker, significantly diminished both the ATP-induced increase in CBF and the initial transient [Ca(2+)](i) component.	Adenosine Triphosphate	77-80	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-33
15175223-6	2004	ATP addition in the presence of xestospongin C or thapsigargin revealed that the Ca(2+) influx is also dependent on IP(3) receptor activation.	Adenosine Triphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	116-130
15175223-6	2004	ATP addition in the presence of xestospongin C or thapsigargin revealed that the Ca(2+) influx is also dependent on IP(3) receptor activation.	xestospongin C	32-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	116-130
15175223-6	2004	ATP addition in the presence of xestospongin C or thapsigargin revealed that the Ca(2+) influx is also dependent on IP(3) receptor activation.	Thapsigargin	50-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	116-130
15175223-10	2004	Our study demonstrates for the first time the presence of IP(3) receptor type 3 in the plasma membrane in ciliated cells and leads us to postulate that the IP(3) receptor can directly trigger Ca(2+) influx in response to ATP.	Adenosine Triphosphate	221-224	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-72
15175223-10	2004	Our study demonstrates for the first time the presence of IP(3) receptor type 3 in the plasma membrane in ciliated cells and leads us to postulate that the IP(3) receptor can directly trigger Ca(2+) influx in response to ATP.	Adenosine Triphosphate	221-224	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	156-170
15384203-5	2004	In contrast, both caffeine, a RyR activator, and 2-aminoethoxydiphenylborate (2-APB), a membrane-permeable inositol 1,4,5-trisphosphate receptors, (IP3R) antagonist, increased STOCs activity.	2-aminoethoxydiphenyl borate	78-83	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	148-152
15326217-5	2004	To investigate the participation of the inositol trisphosphate (IP(3)) receptors (IP(3)R), we utilized two inhibitors of the mammalian IP(3)R, TMB-8 and 2-APB.	2-aminoethoxydiphenyl borate	153-158	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-88
15266018-7	2004	Therefore, suramin also potently inhibited IP(3)-induced Ca(2+) release (IICR) from permeabilized cells predominantly expressing IP(3)R1 (L15 fibroblasts) or IP(3)R3 (Lvec fibroblasts), even though the IP(3)R3 does not contain Ca(2+)-dependent CaM-binding sites.	Suramin	11-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	158-165
15266018-7	2004	Therefore, suramin also potently inhibited IP(3)-induced Ca(2+) release (IICR) from permeabilized cells predominantly expressing IP(3)R1 (L15 fibroblasts) or IP(3)R3 (Lvec fibroblasts), even though the IP(3)R3 does not contain Ca(2+)-dependent CaM-binding sites.	Suramin	11-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	202-209
15266018-7	2004	Therefore, suramin also potently inhibited IP(3)-induced Ca(2+) release (IICR) from permeabilized cells predominantly expressing IP(3)R1 (L15 fibroblasts) or IP(3)R3 (Lvec fibroblasts), even though the IP(3)R3 does not contain Ca(2+)-dependent CaM-binding sites.	Inositol 1,4,5-Trisphosphate	43-48	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	202-209
15223153-2	2004	The possible role of Ca(2+) release from the inositol 1,4,5-trisphosphate (IP(3)) receptor channel in the regulation of the phosphorylation-dephosphorylation cycle process involved in glycogen degradation by glycogen phosphorylase have theoretically investigated by using the Li-Rinzel model for cytosolic Ca(2+) oscillations.	Glycogen	184-192	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	75-90
15280576-5	2004	To account for the most recent findings, we propose that two distinct classes of calcium-conducting channels may exist in plasma membrane, which respond to different signals: SOCs, which are activated by depletion of calcium stores through the CIF-iPLA2 mechanism [no inositol triphosphate (IP3) needed]; and IP3 receptor-operated channels (IP3ROCs), which are activated by IP3 receptor through a direct coupling mechanism (no store depletion is needed).	Calcium	81-88	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	309-321
15280576-5	2004	To account for the most recent findings, we propose that two distinct classes of calcium-conducting channels may exist in plasma membrane, which respond to different signals: SOCs, which are activated by depletion of calcium stores through the CIF-iPLA2 mechanism [no inositol triphosphate (IP3) needed]; and IP3 receptor-operated channels (IP3ROCs), which are activated by IP3 receptor through a direct coupling mechanism (no store depletion is needed).	Calcium	81-88	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	374-386
15048932-9	2004	We found that diphenylboric acid 2-aminoethyl ester, a cell-permeable inositol 1,4,5-trisphosphate (IP(3)) receptor antagonist, greatly reduced mechanically induced glutamate release.	diphenylboric acid 2-aminoethyl ester	14-51	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-115
15066902-8	2004	Modulation of the ER calcium pools using CMC (4-chloro-m-cresol) and ATP revealed lower ryanodine receptor (RyR) and IP(3) receptor (IP(3)R)-sensitive Ca2+ stores in the chemoresistant cell line.	Calcium	21-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-131
15066902-8	2004	Modulation of the ER calcium pools using CMC (4-chloro-m-cresol) and ATP revealed lower ryanodine receptor (RyR) and IP(3) receptor (IP(3)R)-sensitive Ca2+ stores in the chemoresistant cell line.	Calcium	21-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	133-139
15066902-8	2004	Modulation of the ER calcium pools using CMC (4-chloro-m-cresol) and ATP revealed lower ryanodine receptor (RyR) and IP(3) receptor (IP(3)R)-sensitive Ca2+ stores in the chemoresistant cell line.	chlorocresol	41-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-131
15066902-8	2004	Modulation of the ER calcium pools using CMC (4-chloro-m-cresol) and ATP revealed lower ryanodine receptor (RyR) and IP(3) receptor (IP(3)R)-sensitive Ca2+ stores in the chemoresistant cell line.	chlorocresol	41-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	133-139
15066902-8	2004	Modulation of the ER calcium pools using CMC (4-chloro-m-cresol) and ATP revealed lower ryanodine receptor (RyR) and IP(3) receptor (IP(3)R)-sensitive Ca2+ stores in the chemoresistant cell line.	chlorocresol	46-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-131
14695351-5	2004	By voltage-clamp recording, Ca(2+) influx through voltage-dependent Ca(2+) channels (VDCCs) was shown to be responsible for activating the initial SK current, whereas the IP(3)R blocker heparin abolished the delayed component.	Heparin	186-193	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	171-177
15160398-7	2004	Dantrolene and xestospongin C, inhibitors of ER Ca(2+) release through RyR or IP(3)R, were able to prevent the increase in [Ca(2+)](i) and the activation of caspase-3 and to protect partially against apoptosis induced by treatment with A beta(25-35) or A beta(1-40).	Dantrolene	0-10	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-84
15160398-7	2004	Dantrolene and xestospongin C, inhibitors of ER Ca(2+) release through RyR or IP(3)R, were able to prevent the increase in [Ca(2+)](i) and the activation of caspase-3 and to protect partially against apoptosis induced by treatment with A beta(25-35) or A beta(1-40).	xestospongin C	15-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-84
15093614-11	2004	Thrombin-induced [Ca2+]i of GF is mainly due to PAR-1 activation, extracellular calcium influx via L-type calcium channel, PLC activation, then IP3 binding to IP3 receptor in sarcoplasmic reticulum, which leads to intracellular calcium release and subsequently alters cell membrane capacitative calcium entry.	Inositol 1,4,5-Trisphosphate	144-147	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-171
15066902-8	2004	Modulation of the ER calcium pools using CMC (4-chloro-m-cresol) and ATP revealed lower ryanodine receptor (RyR) and IP(3) receptor (IP(3)R)-sensitive Ca2+ stores in the chemoresistant cell line.	chlorocresol	46-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	133-139
15066902-8	2004	Modulation of the ER calcium pools using CMC (4-chloro-m-cresol) and ATP revealed lower ryanodine receptor (RyR) and IP(3) receptor (IP(3)R)-sensitive Ca2+ stores in the chemoresistant cell line.	Adenosine Triphosphate	69-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-131
15066902-8	2004	Modulation of the ER calcium pools using CMC (4-chloro-m-cresol) and ATP revealed lower ryanodine receptor (RyR) and IP(3) receptor (IP(3)R)-sensitive Ca2+ stores in the chemoresistant cell line.	Adenosine Triphosphate	69-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	133-139
15003850-0	2004	A model of IP3 receptor with a luminal calcium binding site: stochastic simulations and analysis.	Calcium	39-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	11-23
15048932-9	2004	We found that diphenylboric acid 2-aminoethyl ester, a cell-permeable inositol 1,4,5-trisphosphate (IP(3)) receptor antagonist, greatly reduced mechanically induced glutamate release.	Inositol 1,4,5-Trisphosphate	70-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-115
15048932-9	2004	We found that diphenylboric acid 2-aminoethyl ester, a cell-permeable inositol 1,4,5-trisphosphate (IP(3)) receptor antagonist, greatly reduced mechanically induced glutamate release.	Glutamic Acid	165-174	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	100-115
14726673-6	2004	This interaction blocks the calcium-dependent inhibition of IP3R function, resulting in increased calcium release from internal stores.	Calcium	28-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-64
14754996-4	2004	These effects were prevented by the IP(3) receptor (IP(3)R) blocker aminoethoxydiphenyl borate (2-APB), suggesting the involvement of IP(3)-dependent SR Ca(2+) release.	aminoethoxydiphenyl borate	68-94	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	36-50
14754996-4	2004	These effects were prevented by the IP(3) receptor (IP(3)R) blocker aminoethoxydiphenyl borate (2-APB), suggesting the involvement of IP(3)-dependent SR Ca(2+) release.	aminoethoxydiphenyl borate	68-94	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	52-58
14754996-4	2004	These effects were prevented by the IP(3) receptor (IP(3)R) blocker aminoethoxydiphenyl borate (2-APB), suggesting the involvement of IP(3)-dependent SR Ca(2+) release.	2-aminoethoxydiphenyl borate	96-101	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	36-50
14754996-4	2004	These effects were prevented by the IP(3) receptor (IP(3)R) blocker aminoethoxydiphenyl borate (2-APB), suggesting the involvement of IP(3)-dependent SR Ca(2+) release.	2-aminoethoxydiphenyl borate	96-101	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	52-58
14754996-5	2004	In saponin-permeabilized myocytes IP(3) and the more potent IP(3)R agonist adenophostin increased basal [Ca(2+)](i) and the frequency of spontaneous Ca(2+) sparks.	Saponins	3-10	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-66
14754996-5	2004	In saponin-permeabilized myocytes IP(3) and the more potent IP(3)R agonist adenophostin increased basal [Ca(2+)](i) and the frequency of spontaneous Ca(2+) sparks.	adenophostin A	75-87	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-66
14754996-6	2004	In the presence of tetracaine to eliminate Ca(2+) release from ryanodine receptor (RyR) SR Ca(2+) release channels, IP(3) and adenophostin triggered unique elementary, non-propagating IP(3)R-dependent Ca(2+) release events with amplitudes and kinetics that were distinctly different from classical RyR-dependent Ca(2+) sparks.	Inositol 1,4,5-Trisphosphate	116-121	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	184-190
14754996-6	2004	In the presence of tetracaine to eliminate Ca(2+) release from ryanodine receptor (RyR) SR Ca(2+) release channels, IP(3) and adenophostin triggered unique elementary, non-propagating IP(3)R-dependent Ca(2+) release events with amplitudes and kinetics that were distinctly different from classical RyR-dependent Ca(2+) sparks.	adenophostin A	126-138	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	184-190
14726673-6	2004	This interaction blocks the calcium-dependent inhibition of IP3R function, resulting in increased calcium release from internal stores.	Calcium	98-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-64
15189149-1	2004	The inositol 1,4,5 trisphosphate (IP3) receptor (IP3R) is a Ca2+ release channel that responds to the second messenger IP3.	Inositol 1,4,5-Trisphosphate	34-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
14755130-6	2004	The results showed that adenosine induced, in a dose-dependent manner, a calcium mobilization from IP(3)-sensitive intracellular stores since the IP(3) receptor blocker 2-APB was able to suppress the calcium response.	Adenosine	24-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	146-160
15709700-3	2004	In this tissue, most cytoplasmic and nuclear calcium signals originate from calcium release from internal stores, mediated either by ryanodine receptor (RyR) or IP3 receptor (IP3R) channels.	Calcium	45-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	161-173
15709700-3	2004	In this tissue, most cytoplasmic and nuclear calcium signals originate from calcium release from internal stores, mediated either by ryanodine receptor (RyR) or IP3 receptor (IP3R) channels.	Calcium	45-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	175-179
15709700-3	2004	In this tissue, most cytoplasmic and nuclear calcium signals originate from calcium release from internal stores, mediated either by ryanodine receptor (RyR) or IP3 receptor (IP3R) channels.	Calcium	76-83	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	175-179
15709700-5	2004	The calcium signals mediated by RyR and IP3R are very different in kinetics, amplitude and subcellular localization; an open question is whether these differences are differentially sensed by transcription factors.	Calcium	4-11	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-44
14755130-10	2004	Based on the experimental data, a signaling pathway is proposed involving adenylate cyclase and protein kinase A, which causes phosphorylation of the IP(3) receptor, with a cross-talk between the signaling pathways activated by ghrelin and adenosine.	Ghrelin	228-235	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	150-164
14755130-6	2004	The results showed that adenosine induced, in a dose-dependent manner, a calcium mobilization from IP(3)-sensitive intracellular stores since the IP(3) receptor blocker 2-APB was able to suppress the calcium response.	Calcium	73-80	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	146-160
14755130-10	2004	Based on the experimental data, a signaling pathway is proposed involving adenylate cyclase and protein kinase A, which causes phosphorylation of the IP(3) receptor, with a cross-talk between the signaling pathways activated by ghrelin and adenosine.	Adenosine	240-249	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	150-164
14755130-6	2004	The results showed that adenosine induced, in a dose-dependent manner, a calcium mobilization from IP(3)-sensitive intracellular stores since the IP(3) receptor blocker 2-APB was able to suppress the calcium response.	Inositol 1,4,5-Trisphosphate	99-104	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	146-160
14755130-6	2004	The results showed that adenosine induced, in a dose-dependent manner, a calcium mobilization from IP(3)-sensitive intracellular stores since the IP(3) receptor blocker 2-APB was able to suppress the calcium response.	2-aminoethoxydiphenyl borate	169-174	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	146-160
14755130-6	2004	The results showed that adenosine induced, in a dose-dependent manner, a calcium mobilization from IP(3)-sensitive intracellular stores since the IP(3) receptor blocker 2-APB was able to suppress the calcium response.	Calcium	200-207	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	146-160
15283963-3	2004	GABA(A)R-gated IPSCs were enhanced by the postsynaptic infusions of adenophostin (1 microM), a potent agonist of inositol-1,4,5-triphosphate receptor (IP(3)R) that induces Ca(2+) release.	gamma-Aminobutyric Acid	0-4	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	151-157
14706780-7	2004	Inhibition of the inositol 1,4,5-trisphosphate (IP(3)) receptor with 200 microM 2-aminoethoxydiphenylborate (2APB) abolished LPA signals.	2-aminoethoxydiphenyl borate	80-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-63
15283963-3	2004	GABA(A)R-gated IPSCs were enhanced by the postsynaptic infusions of adenophostin (1 microM), a potent agonist of inositol-1,4,5-triphosphate receptor (IP(3)R) that induces Ca(2+) release.	adenophostin A	68-80	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	151-157
15283963-8	2004	In the investigation of synaptic targets for the enhancement, we found that IP(3)R agonist-enhanced GABA(A)R-gated IPSCs were attenuated by co-infusing colchicine (30 microM), vincristine (3 microM) or cytochalasin D (1 microM) that inhibits tubulin or actin polymerization, implying that actin filament and microtubules are involved.	gamma-Aminobutyric Acid	100-104	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-82
15283963-8	2004	In the investigation of synaptic targets for the enhancement, we found that IP(3)R agonist-enhanced GABA(A)R-gated IPSCs were attenuated by co-infusing colchicine (30 microM), vincristine (3 microM) or cytochalasin D (1 microM) that inhibits tubulin or actin polymerization, implying that actin filament and microtubules are involved.	Colchicine	152-162	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-82
15283963-8	2004	In the investigation of synaptic targets for the enhancement, we found that IP(3)R agonist-enhanced GABA(A)R-gated IPSCs were attenuated by co-infusing colchicine (30 microM), vincristine (3 microM) or cytochalasin D (1 microM) that inhibits tubulin or actin polymerization, implying that actin filament and microtubules are involved.	Vincristine	176-187	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-82
15104179-5	2004	Although TRPC3 can also be activated by diacylglycerols, there is evidence suggesting that these channels can be activated by IP3 and the IP3 receptor through a conformational coupling mechanism.	Diglycerides	40-55	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	138-150
15283963-8	2004	In the investigation of synaptic targets for the enhancement, we found that IP(3)R agonist-enhanced GABA(A)R-gated IPSCs were attenuated by co-infusing colchicine (30 microM), vincristine (3 microM) or cytochalasin D (1 microM) that inhibits tubulin or actin polymerization, implying that actin filament and microtubules are involved.	Cytochalasin D	202-216	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-82
14500581-5	2003	Intracellular application of the IP3 receptor antagonist heparin abolished fNT-induced electrical activity.	Heparin	57-64	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	33-45
14644452-1	2003	Although the inositol 1,4,5-triphosphate (IP(3))-induced nuclear Ca(2+) release has been shown to play key roles in nuclear functions, the presence of IP(3) receptor (IP(3)R)/Ca(2+) channels in the nucleoplasm has not been found.	Inositol 1,4,5-Trisphosphate	13-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	167-173
14644452-1	2003	Although the inositol 1,4,5-triphosphate (IP(3))-induced nuclear Ca(2+) release has been shown to play key roles in nuclear functions, the presence of IP(3) receptor (IP(3)R)/Ca(2+) channels in the nucleoplasm has not been found.	Inositol 1,4,5-Trisphosphate	42-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	151-165
14644452-1	2003	Although the inositol 1,4,5-triphosphate (IP(3))-induced nuclear Ca(2+) release has been shown to play key roles in nuclear functions, the presence of IP(3) receptor (IP(3)R)/Ca(2+) channels in the nucleoplasm has not been found.	Inositol 1,4,5-Trisphosphate	42-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	167-173
14500581-5	2003	Intracellular application of the IP3 receptor antagonist heparin abolished fNT-induced electrical activity.	NIFURTHIAZOLE	75-78	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	33-45
14666665-11	2003	As cells which express IP3R3 mRNA (i.e. pancreas ascinar cells) are known to have a secretory function in which IP3/Ca2+ signaling has been shown to be involved, IP3R3 may be a prerequisite for secretion of an enzyme, such as protease, in gastric cancer cells.	Inositol 1,4,5-Trisphosphate	23-26	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	162-167
12820984-1	2003	Inositol 1,4,5-trisphosphate (IP(3)) is one of the second messengers produced by phosphoinositid hydrolysis and triggers IP(3) receptor (IP(3)R) mediated calcium release from intracellular pools.	Inositol 1,4,5-Trisphosphate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	121-135
12820984-1	2003	Inositol 1,4,5-trisphosphate (IP(3)) is one of the second messengers produced by phosphoinositid hydrolysis and triggers IP(3) receptor (IP(3)R) mediated calcium release from intracellular pools.	Inositol 1,4,5-Trisphosphate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	137-143
12820984-1	2003	Inositol 1,4,5-trisphosphate (IP(3)) is one of the second messengers produced by phosphoinositid hydrolysis and triggers IP(3) receptor (IP(3)R) mediated calcium release from intracellular pools.	Inositol 1,4,5-Trisphosphate	30-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	121-135
12820984-1	2003	Inositol 1,4,5-trisphosphate (IP(3)) is one of the second messengers produced by phosphoinositid hydrolysis and triggers IP(3) receptor (IP(3)R) mediated calcium release from intracellular pools.	Inositol 1,4,5-Trisphosphate	30-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	137-143
12820984-1	2003	Inositol 1,4,5-trisphosphate (IP(3)) is one of the second messengers produced by phosphoinositid hydrolysis and triggers IP(3) receptor (IP(3)R) mediated calcium release from intracellular pools.	phosphoinositid	81-96	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	137-143
12820984-1	2003	Inositol 1,4,5-trisphosphate (IP(3)) is one of the second messengers produced by phosphoinositid hydrolysis and triggers IP(3) receptor (IP(3)R) mediated calcium release from intracellular pools.	Calcium	154-161	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	121-135
12820984-1	2003	Inositol 1,4,5-trisphosphate (IP(3)) is one of the second messengers produced by phosphoinositid hydrolysis and triggers IP(3) receptor (IP(3)R) mediated calcium release from intracellular pools.	Calcium	154-161	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	137-143
14619519-11	2003	As cells that express IP3R3 mRNA (i.e., pancreatic aciner cells) are known to have a secretory function in which IP3/Ca2+ signaling has been shown to be involved, IP3R3 may be a prerequisite for secretion in gastric cancer cells.	Inositol 1,4,5-Trisphosphate	22-25	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	163-168
14505576-2	2003	For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C activates an intracellular store calcium channel, the IP(3)R.	Inositol triphosphate	13-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-146
14505576-2	2003	For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C activates an intracellular store calcium channel, the IP(3)R.	Inositol 1,4,5-Trisphosphate	36-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-146
12967979-5	2003	Ca2+ imaging experiments show calcium release at the motor endplate upon K+ depolarization precisely in these IP3R-rich regions.	Calcium	30-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
12921667-10	2003	(3)The increase of Ca(2+) concentration induced by caffeine or ryanodine suggested the involvement of both the cyclic adenosine diphosphate ribose and the inositol 1,4,5-triphosphate systems in the regulation of intracellular calcium in LEC-B3, and IP(3R) is more sensitive to free Ca(2+) modulation than RyR.	Caffeine	51-59	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	249-254
12754204-8	2003	Heparin inhibition of endogenous inositol trisphosphate receptors (IP3R) had little effect on intracellular Ca2+ handling or viability.	Heparin	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	67-71
12730194-5	2003	Mutation of conserved YQ and MKR motifs to alanine within the CIRB region in TRPC3-Topaz, which would be expected to interfere with IP3 receptor and/or calmodulin binding, had no effect on channel function or targeting.	Alanine	43-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	132-144
12921667-10	2003	(3)The increase of Ca(2+) concentration induced by caffeine or ryanodine suggested the involvement of both the cyclic adenosine diphosphate ribose and the inositol 1,4,5-triphosphate systems in the regulation of intracellular calcium in LEC-B3, and IP(3R) is more sensitive to free Ca(2+) modulation than RyR.	Ryanodine	63-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	249-254
12601149-1	2003	Examination of store-operated Ca(2+) entry (SOC) in single, mechanically skinned skeletal muscle cells by confocal microscopy shows that the inositol 1,4,5-trisphosphate (IP(3)) receptor acts as a sarcoplasmic reticulum [Ca(2+)] sensor and mediates SOC by physical coupling without playing a key role in Ca(2+) release from internal stores, as is the case with various cell types in which SOC was investigated previously.	1,4,5-trisphosphate	150-169	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	171-186
12747838-5	2003	This can be due to activation of PLCbeta1 or direct activation of the IP(3)R by Gbetagamma.	gbetagamma	80-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-76
12747838-6	2003	We report here that Gbetagamma potently activates the IP(3) receptor.	gbetagamma	20-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	54-68
12747838-12	2003	We propose that gating of IP(3)R by Gbetagamma is a new mode of Ca(2+) signaling with particular significance for Gi-coupled receptors.	gbetagamma	36-46	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	26-32
12719484-2	2003	For this purpose the membrane-permeable IP3 receptor antagonist 2-aminoethoxydiphenyl borate (2APB) (Maruyama, T., T. Kanaji, S. Nakade, T. Kanno, and K. Mikoshiba.	2-aminoethoxydiphenyl borate	64-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-52
12632182-3	2003	This review focuses on the pharmacological modulation of the various functionally important sub-domains of the IP(3)R, including the IP(3)-binding domain, calmodulin-binding sites, adenine nucleotide-binding sites and the sites for interaction for FK506-binding proteins and other regulators.	Adenine Nucleotides	181-199	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-117
12632182-3	2003	This review focuses on the pharmacological modulation of the various functionally important sub-domains of the IP(3)R, including the IP(3)-binding domain, calmodulin-binding sites, adenine nucleotide-binding sites and the sites for interaction for FK506-binding proteins and other regulators.	Tacrolimus	248-253	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	111-117
12429572-15	2002	Inositol 1,4,5-triphosphate IP3 receptor inhibitor heparin reduced ACh-induced contraction.	inositol 1,4,5	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-40
12529267-1	2003	This study examined the expression of inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) types and PKG isoforms in isolated gastric smooth muscle cells and determined the ability of PKG and PKA to phosphorylate IP(3)Rs and inhibit IP(3)-dependent Ca(2+) release, which mediates the initial phase of agonist-induced contraction.	Inositol 1,4,5-Trisphosphate	68-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-91
12468029-6	2002	Further, we found that FBP enhancement of phospho-ERK immunostaining depended on [Ca(2+)](i): PLC inhibition and the IP(3) receptor blocker xestospongin C prevented FBP from increasing [Ca(2+)](i) and increasing phospho-ERK levels.	xestospongin C	140-154	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-131
12429572-15	2002	Inositol 1,4,5-triphosphate IP3 receptor inhibitor heparin reduced ACh-induced contraction.	Heparin	51-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-40
12429572-15	2002	Inositol 1,4,5-triphosphate IP3 receptor inhibitor heparin reduced ACh-induced contraction.	Acetylcholine	67-70	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-40
12088506-2	2002	In cytosol-like medium, each of the three mammalian IP(3) receptor subtypes when expressed in Sf9 cells bound adenophostin A with greater affinity than IP(3).	adenophostin A	110-124	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	52-66
12453054-6	2002	Application of the membrane-permeant Ca2+ chelator BAPTA-AM, the sarcoendoplasmic reticulum Ca2+-ATPase inhibitor thapsigargin, or the IP3 receptor antagonist 2-APB suppressed the reduction of Ca2+ currents induced by f NT.	2-aminoethoxydiphenyl borate	159-164	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	135-147
12381785-7	2002	Likewise, inositol 1,4,5-trisphosphate (IP(3)) receptor antagonists xestospongin C and caffeine selectively blocked the second phase, but not the initiation of insulin signaling.	inositol 1,4,5	10-24	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-55
12381785-7	2002	Likewise, inositol 1,4,5-trisphosphate (IP(3)) receptor antagonists xestospongin C and caffeine selectively blocked the second phase, but not the initiation of insulin signaling.	xestospongin C	68-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-55
12381785-7	2002	Likewise, inositol 1,4,5-trisphosphate (IP(3)) receptor antagonists xestospongin C and caffeine selectively blocked the second phase, but not the initiation of insulin signaling.	Caffeine	87-95	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-55
12445455-4	2002	In this review we will first discuss the role of calcium as an activator and inactivator of the IP(3)R, concluding that calcium is the most important regulator of the IP(3)R.	Calcium	49-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-102
12445455-4	2002	In this review we will first discuss the role of calcium as an activator and inactivator of the IP(3)R, concluding that calcium is the most important regulator of the IP(3)R.	Calcium	120-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-102
12445455-4	2002	In this review we will first discuss the role of calcium as an activator and inactivator of the IP(3)R, concluding that calcium is the most important regulator of the IP(3)R.	Calcium	120-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	167-173
12513459-2	2002	We investigated the temporal behavior of a single cluster of inositol-(1,4,5)-triphosphate receptor (IP3R)-I channels and will present an analytic approach to obtain the spectrum of the calcium signal within the cluster.	Calcium	186-193	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-105
12198155-1	2002	We examined the roles of inositol 1,4,5-trisphosphate (IP3) receptors (IP3R) in calcium signaling using DT40 B lymphocytes, and a variant lacking the three IP3R isoforms (IP3R-KO).	Calcium	80-87	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	71-75
12198155-4	2002	Expression of the type-3 IP3R (IP3R-3) in the IP3R-KO cells rescued not only agonist-dependent release of intracellular Ca2+, but also Ba2+ influx following receptor stimulation.	N-methyl-valyl-amiclenomycin	135-139	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	25-29
12198155-4	2002	Expression of the type-3 IP3R (IP3R-3) in the IP3R-KO cells rescued not only agonist-dependent release of intracellular Ca2+, but also Ba2+ influx following receptor stimulation.	N-methyl-valyl-amiclenomycin	135-139	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	31-37
12198155-4	2002	Expression of the type-3 IP3R (IP3R-3) in the IP3R-KO cells rescued not only agonist-dependent release of intracellular Ca2+, but also Ba2+ influx following receptor stimulation.	N-methyl-valyl-amiclenomycin	135-139	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	31-35
12198155-5	2002	Similar results were obtained with an IP3R-3 mutant carrying a conservative point mutation in the selectivity filter region of the channel (D2477E); however, an IP3R-3 mutant in which this same aspartate was replaced by alanine (D2477A) failed to restore either BCR-induced Ca2+ release or receptor-dependent Ba2+ entry.	Alanine	220-227	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	161-167
11980717-1	2002	Calcium spikes established by IP(3) receptor-mediated Ca(2+) release from the endoplasmic reticulum (ER) are transmitted effectively to the mitochondria, utilizing local Ca(2+) interactions between closely associated subdomains of the ER and mitochondria.	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	30-44
12161107-7	2002	Ca(2+) humps in the transfected cells were associated with a high expression level of IP(3)R3.	ca(2+) humps	0-12	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-93
12065669-7	2002	Intracellular Ca2+ stores were implicated in both the initial and sustained nicotine-evoked Ca2+ responses, by the blockade observed after ryanodine (30 microm) and the inositoltriphosphate (IP3)-receptor antagonist, xestospongin-c (10 microm).	Nicotine	76-84	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	191-204
11958992-1	2002	Inositol 1,4,5-trisphosphate (IP(3)) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP(3) for strong binding to the IP(3) receptor.	Inositol 1,4,5-Trisphosphate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-186
11858944-11	2002	R-PIA-induced contraction of esophageal muscle cells was inhibited by IP(3) receptor antagonist heparin, which suggests that the contraction of esophageal smooth muscle cells is dependent on phosphatidylinositol-specific phospholipase (PI-PLC) and IP(3).	Heparin	96-103	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-84
11858944-11	2002	R-PIA-induced contraction of esophageal muscle cells was inhibited by IP(3) receptor antagonist heparin, which suggests that the contraction of esophageal smooth muscle cells is dependent on phosphatidylinositol-specific phospholipase (PI-PLC) and IP(3).	Phosphatidylinositols	191-211	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-84
11858944-14	2002	PI hydrolysis by PI-PLC forms IP(3), which binds to IP(3) receptor on endoplasmic reticulum, resulting in the release of intracellular Ca(2+).	Inositol 1,4,5-Trisphosphate	30-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	52-66
11971217-11	2002	(4) The expression of inositol- 1,4,5-triphosphate receptor (IP3R) was enhanced by H2O2.	Hydrogen Peroxide	83-87	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-65
12065669-7	2002	Intracellular Ca2+ stores were implicated in both the initial and sustained nicotine-evoked Ca2+ responses, by the blockade observed after ryanodine (30 microm) and the inositoltriphosphate (IP3)-receptor antagonist, xestospongin-c (10 microm).	inositoltriphosphate	169-189	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	191-204
12065669-7	2002	Intracellular Ca2+ stores were implicated in both the initial and sustained nicotine-evoked Ca2+ responses, by the blockade observed after ryanodine (30 microm) and the inositoltriphosphate (IP3)-receptor antagonist, xestospongin-c (10 microm).	xestospongin C	217-231	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	191-204
11958992-1	2002	Inositol 1,4,5-trisphosphate (IP(3)) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP(3) for strong binding to the IP(3) receptor.	Inositol 1,4,5-Trisphosphate	30-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-186
11958992-1	2002	Inositol 1,4,5-trisphosphate (IP(3)) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP(3) for strong binding to the IP(3) receptor.	sphingosine 1-phosphate	125-136	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-186
11784768-6	2002	These results indicate that the spontaneous calcium oscillations observed in hippocampal astrocytes in situ are mediated by IP3 receptor activation, are not dependent on neuronal activity, and do not depend on activation of metabotropic glutamate receptors or purinergic receptors.	Calcium	44-51	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	124-136
11782428-0	2002	BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.	Calcium	27-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-103
11782428-0	2002	BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.	Tyrosine	61-69	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-103
11885662-10	2002	Blockade of the inositol 1,4,5-trisphosphate (IP3) receptor on the sarcoplasmic reticulum Ca2+ stores with 2-aminoethoxydiphenyl borate and depletion of Ca2+ stores by inhibition of the sarcoplasmic Ca2+-ATPase with thapsigargin prevented ET-1-induced cytosolic Ca2+ increase and reduced the ET-1-induced vasoconstriction.	Borates	129-135	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-59
11885662-10	2002	Blockade of the inositol 1,4,5-trisphosphate (IP3) receptor on the sarcoplasmic reticulum Ca2+ stores with 2-aminoethoxydiphenyl borate and depletion of Ca2+ stores by inhibition of the sarcoplasmic Ca2+-ATPase with thapsigargin prevented ET-1-induced cytosolic Ca2+ increase and reduced the ET-1-induced vasoconstriction.	Thapsigargin	216-228	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-59
11885662-10	2002	Blockade of the inositol 1,4,5-trisphosphate (IP3) receptor on the sarcoplasmic reticulum Ca2+ stores with 2-aminoethoxydiphenyl borate and depletion of Ca2+ stores by inhibition of the sarcoplasmic Ca2+-ATPase with thapsigargin prevented ET-1-induced cytosolic Ca2+ increase and reduced the ET-1-induced vasoconstriction.	Endothelin-1	239-243	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-59
11885662-10	2002	Blockade of the inositol 1,4,5-trisphosphate (IP3) receptor on the sarcoplasmic reticulum Ca2+ stores with 2-aminoethoxydiphenyl borate and depletion of Ca2+ stores by inhibition of the sarcoplasmic Ca2+-ATPase with thapsigargin prevented ET-1-induced cytosolic Ca2+ increase and reduced the ET-1-induced vasoconstriction.	Endothelin-1	292-296	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-59
11874447-4	2002	From these, a general model is extracted that involves six types of concentration variables: inositol 1,4,5-trisphosphate (IP3), cytoplasmic, endoplasmic reticulum and mitochondrial calcium, the occupied binding sites of calcium buffers, and the fraction of active IP3 receptor calcium release channels.	Calcium	221-228	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	265-277
11969246-4	2002	Fluorescence confocal microscopy showed that the fluorescence of GFP-IP3R3 was distributed to reticular network structures, even after cell permeabilization with saponin.	Saponins	162-169	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	69-74
11687583-2	2002	The calcium pools can be induced to release Ca(2+) via two main types of calcium channel receptor: the inositol 1,4,5-trisphosphate receptor (IP(3)R) and the ryanodine receptor.	Calcium	4-11	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	142-149
11599006-5	2001	We found that the Ca(2+) increase induced by BDNF was completely blocked by xestospongin C, an IP(3) receptor antagonist, and U-73122, a PLC-gamma inhibitor.	xestospongin C	76-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	95-109
11730912-9	2002	The products of phospholipase C activity, diacylglycerol and inositol-trisphosphate (IP(3)), will lead to activation of protein kinase C (PKC) and IP(3)-receptor.	Diglycerides	42-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	147-161
11730912-9	2002	The products of phospholipase C activity, diacylglycerol and inositol-trisphosphate (IP(3)), will lead to activation of protein kinase C (PKC) and IP(3)-receptor.	inositol-trisphosphate	61-83	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	147-161
11730912-9	2002	The products of phospholipase C activity, diacylglycerol and inositol-trisphosphate (IP(3)), will lead to activation of protein kinase C (PKC) and IP(3)-receptor.	Inositol 1,4,5-Trisphosphate	85-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	147-161
12903086-0	2002	Synthesis and biological activity of adenophostin derivatives as IP3 receptor ligands.	adenophostin A	37-49	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-77
12903086-1	2002	The three derivatives of adenophostin A, which were the C-glycosidic analogs 3a and 3b, and the 5"-phenyl analog 4, were designed and synthesized as efficient IP3 receptor ligands.	adenophostin A	25-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-171
11704557-8	2001	Comparison of the effect of cGMP with that of xestospongin C, an inhibitor of the inositol 1,4,5-trisphosphate (IP(3)) receptor, revealed similarities between the action of cGMP and xestospongin C.	xestospongin C	46-60	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-127
11704557-8	2001	Comparison of the effect of cGMP with that of xestospongin C, an inhibitor of the inositol 1,4,5-trisphosphate (IP(3)) receptor, revealed similarities between the action of cGMP and xestospongin C.	Cyclic GMP	173-177	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-127
11704557-8	2001	Comparison of the effect of cGMP with that of xestospongin C, an inhibitor of the inositol 1,4,5-trisphosphate (IP(3)) receptor, revealed similarities between the action of cGMP and xestospongin C.	xestospongin C	182-196	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-127
11704557-9	2001	Therefore, it is likely that cGMP and PKG may target a signal transduction step(s) linked to IP(3) receptor-mediated Ca(2+) release.	Cyclic GMP	29-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-107
11701755-11	2001	These results suggested that the release of Ca(2+) from intracellular stores mediated by the IP(3) receptor was involved in the BDNF-enhanced glutamate release.	Glutamic Acid	142-151	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	93-107
11587552-8	2001	Using Ca2+ induced Ca2+ release (CICR) cell permeable inhibitors for the ryanodine receptor (dantrolene) and the IP3 receptor (2-amino-ethoxydiphenylborate, 2APB) mediated CICR, we demonstrated that CICR was significantly augmented in the "epileptic" neurons, and determined that the IP3 receptor mediated CICR was the major release mechanism altered in epileptogenesis.	cicr	33-37	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	113-125
11243933-1	2001	Calcium signal transmission between endoplasmic reticulum (ER) and mitochondria is supported by a local [Ca(2+)] control that operates between IP(3)receptor Ca(2+)release channels (IP(3)R) and mitochondrial Ca(2+)uptake sites, and displays functional similarities to synaptic transmission.	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	143-156
11465560-8	2001	Exposure to 20 microM Xestospongin D, a cell-permeant IP3 receptor antagonist, resulted in a 45+/-13% decrease in the [Ca2+]i response to halothane compared with halothane exposure alone.	xestospongin D	22-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	54-66
11465560-8	2001	Exposure to 20 microM Xestospongin D, a cell-permeant IP3 receptor antagonist, resulted in a 45+/-13% decrease in the [Ca2+]i response to halothane compared with halothane exposure alone.	Halothane	138-147	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	54-66
11465560-12	2001	CONCLUSIONS: The authors conclude that halothane reduces sarcoplasmic reticulum Ca2+ content in ASM cells via increased Ca2+ leak through both IP3 receptor and ryanodine receptor channels.	Halothane	39-48	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	143-155
11319137-10	2001	Eggs injected with adenophostin A, an IP(3) receptor agonist, showed enhanced Ca(2+) responses to CaCl(2) injections.	adenophostin A	19-33	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	38-52
11319137-10	2001	Eggs injected with adenophostin A, an IP(3) receptor agonist, showed enhanced Ca(2+) responses to CaCl(2) injections.	Calcium Chloride	98-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	38-52
11574661-7	2001	Localization of the IP(3) receptor to the CRT-containing vesicles, in the sperm neck and to the acrosome, suggests that capacitative calcium entry in human spermatozoa may be regulated from these putative calcium storage sites.	Calcium	133-140	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-34
11574661-7	2001	Localization of the IP(3) receptor to the CRT-containing vesicles, in the sperm neck and to the acrosome, suggests that capacitative calcium entry in human spermatozoa may be regulated from these putative calcium storage sites.	Calcium	205-212	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-34
11502886-3	2001	This result supports an intracellular action of 2APB on inositol 1,4,5-trisphosphate (IP(3))-receptor Ca(2+) channels.	Inositol 1,4,5-Trisphosphate	56-84	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-101
11522941-0	2001	Reduced IP3 sensitivity of IP3 receptor in Purkinje neurons.	Inositol 1,4,5-Trisphosphate	8-11	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	27-39
11522941-3	2001	The rate of Ca2+ release is dependent on the IP3 concentration with an EC50 of 25.8 microM, which is &gt; 20-fold greater than that of the IP3R in the isolated preparations or in peripheral cells.	Inositol 1,4,5-Trisphosphate	45-48	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-143
11547341-6	2001	The transient [Ca2+]i increase underwent rapid desensitization, was independent of extracellular Ca2+ and inhibited by the IP3-receptor blocker (75 microm) 2-aminoethoxydiphenyl borate (2-APB) and by depletion of Ca2+ stores with 10(-6) m thapsigargin.	2-aminoethoxydiphenyl borate	156-184	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	123-135
11547341-6	2001	The transient [Ca2+]i increase underwent rapid desensitization, was independent of extracellular Ca2+ and inhibited by the IP3-receptor blocker (75 microm) 2-aminoethoxydiphenyl borate (2-APB) and by depletion of Ca2+ stores with 10(-6) m thapsigargin.	2-aminoethoxydiphenyl borate	186-191	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	123-135
11547341-6	2001	The transient [Ca2+]i increase underwent rapid desensitization, was independent of extracellular Ca2+ and inhibited by the IP3-receptor blocker (75 microm) 2-aminoethoxydiphenyl borate (2-APB) and by depletion of Ca2+ stores with 10(-6) m thapsigargin.	Thapsigargin	239-251	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	123-135
11547341-11	2001	These observations demonstrate that ET-1 mediates a vasoconstriction of the gerbil spiral modiolar artery via ETA receptors and an IP3 receptor-mediated release of Ca2+ from thapsigargin-sensitive Ca2+ stores.	Thapsigargin	174-186	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	131-143
11336651-3	2001	Treatment with xestospongin C, an inhibitor of IP(3) receptor function, abolished SMCE and coupling between the IP(3) receptor and hTrp1.	xestospongin C	15-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	47-61
11336651-3	2001	Treatment with xestospongin C, an inhibitor of IP(3) receptor function, abolished SMCE and coupling between the IP(3) receptor and hTrp1.	xestospongin C	15-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-126
11278266-8	2001	We propose that the pore of IP(3)R channels has two distinct sites that control monovalent cation permeation (Val(2548)) and Ca(2+) selectivity (Asp(2550)).	Valine	110-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-34
11278266-8	2001	We propose that the pore of IP(3)R channels has two distinct sites that control monovalent cation permeation (Val(2548)) and Ca(2+) selectivity (Asp(2550)).	Aspartic Acid	145-148	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-34
11243933-1	2001	Calcium signal transmission between endoplasmic reticulum (ER) and mitochondria is supported by a local [Ca(2+)] control that operates between IP(3)receptor Ca(2+)release channels (IP(3)R) and mitochondrial Ca(2+)uptake sites, and displays functional similarities to synaptic transmission.	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	181-187
11050109-9	2000	The Ca(2+) chelator BAPTA, as well as inhibition of either the inositol trisphosphate (IP(3)) receptor or protein kinase C (PKC) abolished the mGluR7 effect.	Tris phosphate	72-85	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	87-102
11162852-4	2001	Instead, caffeine dose-dependently inhibited IP3 receptor (IP3R)-mediated Ca2+ release, RYR-mediated Ca2+ release and B cell receptor-initiated Ca2+ influx, while high concentrations of caffeine (&gt; or = 25 mM) induced a Ca2+ influx.	Caffeine	9-17	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-57
11162852-4	2001	Instead, caffeine dose-dependently inhibited IP3 receptor (IP3R)-mediated Ca2+ release, RYR-mediated Ca2+ release and B cell receptor-initiated Ca2+ influx, while high concentrations of caffeine (&gt; or = 25 mM) induced a Ca2+ influx.	Caffeine	9-17	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	59-63
11162852-6	2001	Thus, caffeine may act as an inhibitor on a single or multiple site(s) responsible for regulating the IP3R channel, RYR channel and presumably the receptor-mediated SOC channel.	Caffeine	6-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	102-106
11361033-7	2001	In smooth muscle, there are several targets for cyclic nucleotide inhibition and consequent relaxation, including the receptor, G proteins, phospholipase C-beta1-4 isoforms, IP3 receptor, Ca2+ mobilization, MLCK, MAP kinase, Rho-kinase, and myosin phosphatase.	Nucleotides, Cyclic	48-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-186
11469755-0	2001	Conformational analysis of cyclophostin and designed analogs in comparison with the potent IP3 receptor agonist adenophostin A.	adenophostin A	112-126	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	91-103
11469755-1	2001	A conformational analysis of 5"-6"-tethered cyclophostin was carried out in comparison with the mother compound, adenophostin A, which has a potent IP3 receptor agonistic activity.	5"-6"-tethered cyclophostin	29-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	148-160
11469755-1	2001	A conformational analysis of 5"-6"-tethered cyclophostin was carried out in comparison with the mother compound, adenophostin A, which has a potent IP3 receptor agonistic activity.	adenophostin A	113-127	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	148-160
11212221-7	2001	Thimerosal, a thiol reagent which sensitizes the inositol 1,4,5-trisphosphate (IP3) receptor, inhibited the spermine-induced increase in PA(Man) and, to a lesser extent, that of Jw.	Thimerosal	0-10	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-92
11212221-7	2001	Thimerosal, a thiol reagent which sensitizes the inositol 1,4,5-trisphosphate (IP3) receptor, inhibited the spermine-induced increase in PA(Man) and, to a lesser extent, that of Jw.	Sulfhydryl Compounds	14-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-92
11212221-7	2001	Thimerosal, a thiol reagent which sensitizes the inositol 1,4,5-trisphosphate (IP3) receptor, inhibited the spermine-induced increase in PA(Man) and, to a lesser extent, that of Jw.	Spermine	108-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-92
11248050-2	2001	Previous studies showed that human Trp3 is activated by inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) and identified interacting domains, one on Trp and two on IP(3)R.	Tryptophan	35-38	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	104-110
11259864-4	2001	[(3)H]Glutamate uptake was measured after the cells were exposed to 0.1--100 microM mercuric chloride and the selected regulators of protein kinase C (PKC) pathway: PKC activator SC10, PKC inhibitor chelerythrine chloride, phospholipase A(2)/C inhibitor manoalide, tyrosine kinase inhibitor lavendustin A, competitive NMDA receptor antagonist AP7 and IP(3) receptor antagonist heparin.	Glutamic Acid	6-15	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	351-365
11149946-2	2001	The present study found that sigma-1 receptors (Sig-1R), unique endoplasmic reticulum proteins that bind certain steroids, neuroleptics, and psychotropic drugs, form a trimeric complex with ankyrin B and IP(3)R type 3 (IP(3)R-3) in NG-108 cells.	Steroids	113-121	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	204-227
11149946-4	2001	Sig-1R agonists such as pregnenolone sulfate and cocaine caused the dissociation of an ankyrin B isoform (ANK 220) from IP(3)R-3.	pregnenolone sulfate	24-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	120-128
11149946-4	2001	Sig-1R agonists such as pregnenolone sulfate and cocaine caused the dissociation of an ankyrin B isoform (ANK 220) from IP(3)R-3.	Cocaine	49-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	120-128
11149946-8	2001	These results suggest that Sig-1R and associated ligands may play important roles in cells by controlling the function of cytoskeletal proteins and that the Sig-1R/ANK220/IP(3)R-3 complex regulating Ca(2+) signaling may represent a site of action for neurosteroids and cocaine.	Cocaine	269-276	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	164-179
11162491-4	2001	In addition, CaT1 channel activity was markedly inhibited by micromolar levels of a noncompetitive antagonist of the IP3 receptor originally isolated from a marine sponge, Xestospongin C.	xestospongin C	172-186	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	117-129
11068017-2	2000	Phenylephrine (0.1-10 microM) dose-dependently stimulated NO production (0.8-12.9 microM) and this was blocked by NO synthase inhibitor, prazosin, Ca2+-depletion and Xestospongin C (a blocker of the inositol 1,4,5-trisphosphate (IP3) receptor), suggesting that the alpha1-adrenoceptor signaling pathway mediates NO production in C6 cells.	Phenylephrine	0-13	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	229-243
11068017-2	2000	Phenylephrine (0.1-10 microM) dose-dependently stimulated NO production (0.8-12.9 microM) and this was blocked by NO synthase inhibitor, prazosin, Ca2+-depletion and Xestospongin C (a blocker of the inositol 1,4,5-trisphosphate (IP3) receptor), suggesting that the alpha1-adrenoceptor signaling pathway mediates NO production in C6 cells.	xestospongin C	166-180	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	229-243
11068017-5	2000	This finding suggests that cyclosporine may increase phenylephrine-induced NO production by accelerating IP3 receptor function in the alpha1-adrenoceptor signaling pathway in C6 cells.	Cyclosporine	27-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-117
11068017-5	2000	This finding suggests that cyclosporine may increase phenylephrine-induced NO production by accelerating IP3 receptor function in the alpha1-adrenoceptor signaling pathway in C6 cells.	Phenylephrine	53-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-117
11115374-1	2000	Intracellular calcium signals mediated by IP(3)and ryanodine receptors (IP(3)R/RyR) play a central role in cell survival, but emerging evidence suggests that IP(3)R/RyR are also important in apoptotic cell death.	Calcium	14-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-78
11115374-1	2000	Intracellular calcium signals mediated by IP(3)and ryanodine receptors (IP(3)R/RyR) play a central role in cell survival, but emerging evidence suggests that IP(3)R/RyR are also important in apoptotic cell death.	Calcium	14-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	158-164
11115374-4	2000	The functional importance of these mitochondrial calcium signalling pathways has been underscored by the elucidation of a highly effective, local Ca(2+)coupling between IP(3)R/RyR and mitochondrial Ca(2+)uptake sites.	Calcium	49-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	169-175
11032874-3	2000	Following induction of apoptosis by staurosporine, the immunoreactivity of the type I IP(3) receptor in microsome preparations from SH-SY5Y cells was reduced within 2 h, with a further reduction during subsequent hours.	Staurosporine	36-49	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-100
11032874-6	2000	Preincubation of the neuroblastoma cells with the caspase-3 inhibitor Z-Asp-Glu-Val-Asp-fluoromethyl ketone prevented IP(3) receptor degradation.	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	70-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	118-132
10764774-3	2000	Saponin-permeabilized COS cells transfected with type I IP(3)R showed a 50% increase in inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release at saturating [IP(3)] (10 micrometer) but no enhancement at subsaturating [IP(3)] (300 nm).	Inositol 1,4,5-Trisphosphate	118-124	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-62
11752610-0	2000	IP3 receptor-operated calcium entry.	Calcium	22-29	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-12
11752610-2	2000	The authors describe the regulated release of calcium from intracellular stores by the inositol 1,4,5 trisphosphate receptor (IP(3)R) and the relationship of this release mechanism to calcium influx from the extracellular milieu through store-operated calcium channels.	Calcium	46-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-133
11752610-2	2000	The authors describe the regulated release of calcium from intracellular stores by the inositol 1,4,5 trisphosphate receptor (IP(3)R) and the relationship of this release mechanism to calcium influx from the extracellular milieu through store-operated calcium channels.	Calcium	184-191	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-133
10966748-1	2000	Clustered disaccharide analogues of adenophostin A (2), i.e. mono-, di-, and tetravalent derivatives 6-8, respectively, were synthesized and evaluated as novel ligands for the tetrameric D-myo-inositol 1,4, 5-trisphosphate receptor (IP(3)R).	adenophostin A	36-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	233-239
10920015-5	2000	Mutant channels with amino acid residue substitutions that are identical in the RyR and IP(3)R families (D4899A, D4899R, and R4913E) exhibited a decreased K(+) conductance and showed a loss of high-affinity [(3)H]ryanodine binding and loss of single-channel pharmacology but maintained their response to caffeine in a cellular assay.	Ryanodine	213-222	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	88-94
10920015-5	2000	Mutant channels with amino acid residue substitutions that are identical in the RyR and IP(3)R families (D4899A, D4899R, and R4913E) exhibited a decreased K(+) conductance and showed a loss of high-affinity [(3)H]ryanodine binding and loss of single-channel pharmacology but maintained their response to caffeine in a cellular assay.	Caffeine	304-312	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	88-94
10764774-3	2000	Saponin-permeabilized COS cells transfected with type I IP(3)R showed a 50% increase in inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release at saturating [IP(3)] (10 micrometer) but no enhancement at subsaturating [IP(3)] (300 nm).	Saponins	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-62
10764774-3	2000	Saponin-permeabilized COS cells transfected with type I IP(3)R showed a 50% increase in inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release at saturating [IP(3)] (10 micrometer) but no enhancement at subsaturating [IP(3)] (300 nm).	carbonyl sulfide	22-25	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-62
10764774-6	2000	However, microsomal vesicles prepared from cells doubly transfected with IP(3)R and SERCA cDNAs released 33.0 +/- 0.04% of the A23187-sensitive pool within 30 s of 1 micrometer adenophostin A addition.	Calcimycin	127-133	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	73-79
10764774-3	2000	Saponin-permeabilized COS cells transfected with type I IP(3)R showed a 50% increase in inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release at saturating [IP(3)] (10 micrometer) but no enhancement at subsaturating [IP(3)] (300 nm).	Inositol 1,4,5-Trisphosphate	88-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-62
10764774-6	2000	However, microsomal vesicles prepared from cells doubly transfected with IP(3)R and SERCA cDNAs released 33.0 +/- 0.04% of the A23187-sensitive pool within 30 s of 1 micrometer adenophostin A addition.	adenophostin A	177-191	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	73-79
10764774-7	2000	Similarly, the initial rate of (45)Ca(2+) influx into oxalate-loaded microsomal vesicles was inhibited by IP(3) only when the microsomes were prepared from COS cells doubly transfected with SERCA-2b and IP(3)R DNA.	Oxalates	54-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	203-209
10891132-0	2000	Synthesis of the C-glycosidic analogue of adenophostin A and its uracil congener as potential IP(3) receptor ligands.	adenophostin A	42-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	94-108
10748130-5	2000	To examine the functional aspect of this coupling, we measured the IP(3)-mediated Ca(2+) release property of the IP(3)R reconstituted into liposomes in the presence and absence of CGA.	Inositol 1,4,5-Trisphosphate	67-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	113-119
10891132-0	2000	Synthesis of the C-glycosidic analogue of adenophostin A and its uracil congener as potential IP(3) receptor ligands.	Uracil	65-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	94-108
10891132-2	2000	Synthesis of the C-glycosidic analogue 9 of adenophostin A, a very potent IP(3) receptor agonist, and its uracil congener 10 was achieved via a temporary silicon-tethered radical coupling reaction as the key step.	adenophostin A	44-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-88
11013462-6	2000	Furthermore, the caspase inhibitor, Z-VAD-fmk, significantly reduces TNFalpha-mediated perturbation of IP(3)R1 and IP(3)R2 (but not IP(3)R3) function; whereas the calpain inhibitor I, ALLN, is capable of blocking the inhibitory effect of TNFalpha on IP(3)R3 function.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	36-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	250-257
10748130-8	2000	The fluorescence energy transfer and IP(3)R Trp fluorescence quenching studies indicated that the structure of reconstituted IP(3)R becomes more ordered and exposed in the presence of CGA, suggesting that the coupled CGA in the liposome caused structural changes of the IP(3)R, changing it to a structure that is better suited to IP(3) binding and subsequent Ca(2+) release.	Tryptophan	44-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	125-131
10748130-8	2000	The fluorescence energy transfer and IP(3)R Trp fluorescence quenching studies indicated that the structure of reconstituted IP(3)R becomes more ordered and exposed in the presence of CGA, suggesting that the coupled CGA in the liposome caused structural changes of the IP(3)R, changing it to a structure that is better suited to IP(3) binding and subsequent Ca(2+) release.	Tryptophan	44-47	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	125-131
10692444-2	2000	Human T lymphocytes (Jurkat) that are made deficient in IP(3)R do not generate Ca(2+) signals in response to T cell receptor stimulation, fail to translocate the nuclear factor for activated T cells to the nucleus, and are remarkably resistant to induction of apoptosis with CD95 (Fas), dexamethasone, gamma irradiation, and T cell receptor stimulation using anti-CD3 antibody.	ammonium ferrous sulfate	281-284	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-62
10751218-1	2000	Herein we demonstrate that replicative cellular senescence in vitro results in sharply reduced inositol 1,4,5-trisphosphate (IP(3)) receptor levels, reduced mitogen-evoked IP(3) formation and Ca(2+) release, and Ca(2+) store depletion.	Inositol 1,4,5-Trisphosphate	95-123	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	125-140
10692444-2	2000	Human T lymphocytes (Jurkat) that are made deficient in IP(3)R do not generate Ca(2+) signals in response to T cell receptor stimulation, fail to translocate the nuclear factor for activated T cells to the nucleus, and are remarkably resistant to induction of apoptosis with CD95 (Fas), dexamethasone, gamma irradiation, and T cell receptor stimulation using anti-CD3 antibody.	Dexamethasone	287-300	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-62
10644679-1	2000	A 592-amino acid segment of the regulatory domain of the neuronal type-I inositol 1,4,5-trisphosphate receptor (IP(3)R) isoform (type-I long, amino acids1314-1905) and the corresponding 552-amino acid alternatively spliced form present in peripheral tissues (type-I short, amino acids 1693-1733 deleted) were expressed as glutathione S-transferase fusion proteins.	amino acids1314	142-157	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-118
10712640-4	2000	Dialysis of the adenophostin analogues, novel IP3 receptor ligands, also induced inward currents with an increase in membrane conductance.	adenophostin A	16-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-58
10692497-1	2000	Inositol-1,4,5-trisphosphate (IP(3)) releases Ca(2+) from intracellular stores by binding to its receptor (IP(3)R), a multigene family of Ca(2+)-release channels consisting of IP(3)R1, IP(3)R2, and IP(3)R3.	Inositol 1,4,5-Trisphosphate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-113
10692497-1	2000	Inositol-1,4,5-trisphosphate (IP(3)) releases Ca(2+) from intracellular stores by binding to its receptor (IP(3)R), a multigene family of Ca(2+)-release channels consisting of IP(3)R1, IP(3)R2, and IP(3)R3.	Inositol 1,4,5-Trisphosphate	0-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-205
10692497-1	2000	Inositol-1,4,5-trisphosphate (IP(3)) releases Ca(2+) from intracellular stores by binding to its receptor (IP(3)R), a multigene family of Ca(2+)-release channels consisting of IP(3)R1, IP(3)R2, and IP(3)R3.	Inositol 1,4,5-Trisphosphate	30-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-113
10692497-1	2000	Inositol-1,4,5-trisphosphate (IP(3)) releases Ca(2+) from intracellular stores by binding to its receptor (IP(3)R), a multigene family of Ca(2+)-release channels consisting of IP(3)R1, IP(3)R2, and IP(3)R3.	Inositol 1,4,5-Trisphosphate	30-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-205
10836543-4	2000	When the anti-IP3 R antibody or antisense oligonucleotide for IP3 receptor is introduced into the living cells of Blepharisma, both the photosensitivity of the cells and content of blepharismin-200 kD protein are reduced.	Oligonucleotides	42-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-74
10644679-1	2000	A 592-amino acid segment of the regulatory domain of the neuronal type-I inositol 1,4,5-trisphosphate receptor (IP(3)R) isoform (type-I long, amino acids1314-1905) and the corresponding 552-amino acid alternatively spliced form present in peripheral tissues (type-I short, amino acids 1693-1733 deleted) were expressed as glutathione S-transferase fusion proteins.	Glutathione	322-333	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-118
10611319-0	1999	Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry.	Tryptophan	136-139	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-94
11036936-0	2000	Mechanism of capacitative Ca2+ entry (CCE): interaction between IP3 receptor and TRP links the internal calcium storage compartment to plasma membrane CCE channels.	Calcium	104-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	64-76
11036936-1	2000	Activation of cells by agents that stimulate inositol trisphoshate (IP3) formation causes, via IP3 receptor (IP3R) activation, the release of Ca2+ from internal stores and also the entry of Ca2+ via plasma membrane cation channels, referred to as capacitative Ca2+ entry or CCE channels.	inositol trisphoshate	45-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	95-107
11036936-1	2000	Activation of cells by agents that stimulate inositol trisphoshate (IP3) formation causes, via IP3 receptor (IP3R) activation, the release of Ca2+ from internal stores and also the entry of Ca2+ via plasma membrane cation channels, referred to as capacitative Ca2+ entry or CCE channels.	inositol trisphoshate	45-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
11036936-1	2000	Activation of cells by agents that stimulate inositol trisphoshate (IP3) formation causes, via IP3 receptor (IP3R) activation, the release of Ca2+ from internal stores and also the entry of Ca2+ via plasma membrane cation channels, referred to as capacitative Ca2+ entry or CCE channels.	Inositol 1,4,5-Trisphosphate	68-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	95-107
11036936-1	2000	Activation of cells by agents that stimulate inositol trisphoshate (IP3) formation causes, via IP3 receptor (IP3R) activation, the release of Ca2+ from internal stores and also the entry of Ca2+ via plasma membrane cation channels, referred to as capacitative Ca2+ entry or CCE channels.	Inositol 1,4,5-Trisphosphate	68-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
11036936-4	2000	These complexes appear to form in vivo, as evidenced by co-immunoprecipitation of Trp with IP3R and by the fact that expression of the respective interacting sequences modulates development of CCE brought about by store depletion.	Tryptophan	82-85	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	91-95
11036936-5	2000	The finding that a Trp-interacting sequence of IP3R interferes with natural CCE leads us to conclude that Trp proteins are, indeed, structural members of CCE channels.	Tryptophan	19-22	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	47-51
11036936-6	2000	We conclude further that direct coupling of IP3R to Trp is a physiological mechanism by which cells trigger CCE in response to signals that stimulate phosphoinositide hydrolysis and IP3 formation.	Tryptophan	52-55	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	44-48
11036936-6	2000	We conclude further that direct coupling of IP3R to Trp is a physiological mechanism by which cells trigger CCE in response to signals that stimulate phosphoinositide hydrolysis and IP3 formation.	Carbamylcholine	108-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	44-48
11036936-6	2000	We conclude further that direct coupling of IP3R to Trp is a physiological mechanism by which cells trigger CCE in response to signals that stimulate phosphoinositide hydrolysis and IP3 formation.	Phosphatidylinositols	150-166	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	44-48
10611319-2	1999	In agreement with this hypothesis, cells expressing TRPs display novel Ca(2+)-permeable cation channels that can be activated by the inositol 1,4,5-trisphosphate receptor (IP3R) protein.	Tryptophan	52-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-176
10611319-4	1999	Here, we document physical interaction of TRP and IP3R by coimmunoprecipitation and glutathione S-transferase-pulldown experiments and identify two regions of IP3R, F2q and F2g, that interact with one region of TRP, C7.	Glutathione	84-95	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
10611319-4	1999	Here, we document physical interaction of TRP and IP3R by coimmunoprecipitation and glutathione S-transferase-pulldown experiments and identify two regions of IP3R, F2q and F2g, that interact with one region of TRP, C7.	Tryptophan	211-214	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
10611319-4	1999	Here, we document physical interaction of TRP and IP3R by coimmunoprecipitation and glutathione S-transferase-pulldown experiments and identify two regions of IP3R, F2q and F2g, that interact with one region of TRP, C7.	Tryptophan	211-214	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-163
10397504-1	1999	IP3 analogs were synthesized by the modification of phosphate at the 1-position, and their affinity for the IP3 receptor was analyzed by means of surface plasmon resonance measurements.	Inositol 1,4,5-Trisphosphate	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	108-120
10551852-2	1999	With [Ca(2+)](i) strongly buffered to 100 nM, I(crac) was activated by ionomycin, thapsigargin, inositol 1,4,5-trisphosphate (IP(3)), and two metabolically stable IP(3) receptor agonists, adenophostin A and L-alpha-glycerophospho-D-myoinositol-4,5-bisphosphate (GPIP(2)).	crac	48-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	163-177
10551852-2	1999	With [Ca(2+)](i) strongly buffered to 100 nM, I(crac) was activated by ionomycin, thapsigargin, inositol 1,4,5-trisphosphate (IP(3)), and two metabolically stable IP(3) receptor agonists, adenophostin A and L-alpha-glycerophospho-D-myoinositol-4,5-bisphosphate (GPIP(2)).	ip	126-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	163-177
10551852-3	1999	With minimal [Ca(2+)](i) buffering, with [Ca(2+)](i) free to fluctuate I(crac) was activated by ionomycin, thapsigargin, and by the potent IP(3) receptor agonist, adenophostin A, but not by GPIP(2) or IP(3) itself.	crac	73-77	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-153
10551852-3	1999	With minimal [Ca(2+)](i) buffering, with [Ca(2+)](i) free to fluctuate I(crac) was activated by ionomycin, thapsigargin, and by the potent IP(3) receptor agonist, adenophostin A, but not by GPIP(2) or IP(3) itself.	Ionomycin	96-105	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-153
10551852-3	1999	With minimal [Ca(2+)](i) buffering, with [Ca(2+)](i) free to fluctuate I(crac) was activated by ionomycin, thapsigargin, and by the potent IP(3) receptor agonist, adenophostin A, but not by GPIP(2) or IP(3) itself.	Thapsigargin	107-119	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-153
10551852-3	1999	With minimal [Ca(2+)](i) buffering, with [Ca(2+)](i) free to fluctuate I(crac) was activated by ionomycin, thapsigargin, and by the potent IP(3) receptor agonist, adenophostin A, but not by GPIP(2) or IP(3) itself.	adenophostin A	163-177	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-153
10551852-3	1999	With minimal [Ca(2+)](i) buffering, with [Ca(2+)](i) free to fluctuate I(crac) was activated by ionomycin, thapsigargin, and by the potent IP(3) receptor agonist, adenophostin A, but not by GPIP(2) or IP(3) itself.	gpip	190-194	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-153
10551852-6	1999	Our findings suggest that when IP(3) activates the IP(3) receptor, the resulting influx of Ca(2+) quickly inactivates the receptor, and Ca(2+) is re-accumulated at sites that regulate I(crac).	Inositol 1,4,5-Trisphosphate	31-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	51-65
10551852-6	1999	Our findings suggest that when IP(3) activates the IP(3) receptor, the resulting influx of Ca(2+) quickly inactivates the receptor, and Ca(2+) is re-accumulated at sites that regulate I(crac).	crac	186-190	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	51-65
10551852-8	1999	Comparison of thapsigargin-releasable Ca(2+) pools following activation by different IP(3) receptor agonists indicates that the critical regulatory pool of Ca(2+) may be very small in comparison to the total IP(3)-sensitive component of the endoplasmic reticulum.	Thapsigargin	14-26	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	85-99
10516296-8	1999	Moreover, the phospholipase C inhibitor U-73122 and the inositol 1,4,5-trisphosphate (IP3) receptor antagonist xestospongin C blocked the cannabinoid effect, suggesting that the cannabinoid enhancement of NMDA-evoked Ca2+ signals results from enhanced release from IP3-sensitive Ca2+ stores.	Inositol 1,4,5-Trisphosphate	56-84	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-99
10516296-8	1999	Moreover, the phospholipase C inhibitor U-73122 and the inositol 1,4,5-trisphosphate (IP3) receptor antagonist xestospongin C blocked the cannabinoid effect, suggesting that the cannabinoid enhancement of NMDA-evoked Ca2+ signals results from enhanced release from IP3-sensitive Ca2+ stores.	Cannabinoids	138-149	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-99
10516296-8	1999	Moreover, the phospholipase C inhibitor U-73122 and the inositol 1,4,5-trisphosphate (IP3) receptor antagonist xestospongin C blocked the cannabinoid effect, suggesting that the cannabinoid enhancement of NMDA-evoked Ca2+ signals results from enhanced release from IP3-sensitive Ca2+ stores.	Cannabinoids	178-189	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-99
10491627-9	1999	In addition, injection of adenophostin A, a potent IP(3)R agonist that elicits high-frequency [Ca2+]i oscillations in mammalian oocytes, induced similar reduction in receptor numbers.	adenophostin A	26-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	51-57
9850611-2	1998	A family of three IP3 receptor subtype monomers form functional tetramers, which act as effectors for Ins(1,4,5)P3, providing a ligand-gated channel that allows Ca2+ ions to move between cellular compartments.	Inositol 1,4,5-Trisphosphate	102-114	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	18-30
10352035-5	1999	Model simulations agree with previous experimental work on the rates of activation and inactivation of the IP3 receptor by calcium (DuFour, J.-F., I.M.	Calcium	123-130	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	107-119
10352035-11	1999	The steady state open probability curve of the model IP3 receptor is an increasing function of calcium concentration, as found for type-III IP3 receptors by Hagar et al.	Calcium	95-102	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	53-65
10352035-20	1999	We conclude that the differences between CCh- and CCK-induced calcium oscillations in pancreatic acinar cells can be explained by two principal mechanisms: (a) CCK causes more phosphorylation of the IP3 receptor than does CCh, and the phosphorylated receptor cannot pass calcium current; and (b) the rate of calcium ATPase pumping and the rate of calcium influx from the outside the cell are greater in the presence of CCh than in the presence of CCK.	Carbachol	41-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	199-211
10341226-8	1999	Cessation of calcium release via the IP3 receptor might accelerate this fall and thus explain why the cone recovers much faster than the rod.	Calcium	13-20	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	37-49
10341226-9	1999	Furthermore, because its own activity of the IP3 receptor depends partly on cytoplasmic calcium, the receptor might control the set point of cytoplasmic calcium and thus affect cone sensitivity.	Calcium	88-95	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-57
10341226-9	1999	Furthermore, because its own activity of the IP3 receptor depends partly on cytoplasmic calcium, the receptor might control the set point of cytoplasmic calcium and thus affect cone sensitivity.	Calcium	153-160	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-57
10190972-2	1999	We studied these early glucose breakdown products for effects on calcium release and inositol 1,4, 5-trisphosphate (IP3) binding to the IP3 receptor in a pancreatic beta cell preparation.	Glucose	23-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-148
10190972-2	1999	We studied these early glucose breakdown products for effects on calcium release and inositol 1,4, 5-trisphosphate (IP3) binding to the IP3 receptor in a pancreatic beta cell preparation.	Inositol 1,4,5-Trisphosphate	85-114	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-148
10190972-2	1999	We studied these early glucose breakdown products for effects on calcium release and inositol 1,4, 5-trisphosphate (IP3) binding to the IP3 receptor in a pancreatic beta cell preparation.	Inositol 1,4,5-Trisphosphate	116-119	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-148
10213151-6	1999	Together, these data suggest the possibility that IP3-induced Ca2+ release through IP3-R plays a role in the entrainment of the mammalian circadian clock, the SCN.	Inositol 1,4,5-Trisphosphate	50-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	83-88
10378083-6	1999	The suggested mechanism is based on the regulation of local Ca2+ release by cyclic AMP-dependent protein kinase (PKA) and relies upon two experimental observations: first, some G-protein coupled signaling pathways activate PLC and regulate adenylate cyclase at the same time, leading to IP3 production and altering PKA activity via changes in cAMP level; second, phosphorylation by PKA alters the properties of IP3 receptor (IP3R).	Inositol 1,4,5-Trisphosphate	287-290	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	411-423
10378083-6	1999	The suggested mechanism is based on the regulation of local Ca2+ release by cyclic AMP-dependent protein kinase (PKA) and relies upon two experimental observations: first, some G-protein coupled signaling pathways activate PLC and regulate adenylate cyclase at the same time, leading to IP3 production and altering PKA activity via changes in cAMP level; second, phosphorylation by PKA alters the properties of IP3 receptor (IP3R).	Inositol 1,4,5-Trisphosphate	287-290	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	425-429
10378083-6	1999	The suggested mechanism is based on the regulation of local Ca2+ release by cyclic AMP-dependent protein kinase (PKA) and relies upon two experimental observations: first, some G-protein coupled signaling pathways activate PLC and regulate adenylate cyclase at the same time, leading to IP3 production and altering PKA activity via changes in cAMP level; second, phosphorylation by PKA alters the properties of IP3 receptor (IP3R).	Cyclic AMP	343-347	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	411-423
10378083-6	1999	The suggested mechanism is based on the regulation of local Ca2+ release by cyclic AMP-dependent protein kinase (PKA) and relies upon two experimental observations: first, some G-protein coupled signaling pathways activate PLC and regulate adenylate cyclase at the same time, leading to IP3 production and altering PKA activity via changes in cAMP level; second, phosphorylation by PKA alters the properties of IP3 receptor (IP3R).	Cyclic AMP	343-347	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	425-429
16801121-3	1999	Stimulation of platelets with thrombin resulted in tyrosine phosphorylation of the type 1 IP(3)R, which peaked at 3 min followed by dephosphorylation to the basal level by 10 min.	Tyrosine	51-59	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-96
10332802-6	1999	In contrast, intracellular infusion of either GDP beta S or the IP3 receptor antagonist heparin prevented oxo-M mediated enhancement of NMDA depolarizations.	Heparin	88-95	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	64-76
10332802-6	1999	In contrast, intracellular infusion of either GDP beta S or the IP3 receptor antagonist heparin prevented oxo-M mediated enhancement of NMDA depolarizations.	N-Methylaspartate	136-140	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	64-76
10332802-9	1999	Thus, muscarinic-mediated enhancement of NMDA responses involves activation of M1 receptors, leading to the engagement of a postsynaptic G-protein and subsequent IP3 receptor activity.	N-Methylaspartate	41-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	162-174
10318833-1	1999	The concerted action of inositol 1,4,5-trisphosphate (IP3) and Ca2+ on the IP3 receptor Ca2+ release channel (IP3R) is a fundamental step in the generation of cytosolic Ca2+ oscillations and waves, which underlie Ca2+ signaling in many cells.	Inositol 1,4,5-Trisphosphate	24-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
10318833-1	1999	The concerted action of inositol 1,4,5-trisphosphate (IP3) and Ca2+ on the IP3 receptor Ca2+ release channel (IP3R) is a fundamental step in the generation of cytosolic Ca2+ oscillations and waves, which underlie Ca2+ signaling in many cells.	Inositol 1,4,5-Trisphosphate	54-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
10064596-3	1999	We have studied the Ca2+-signalling mechanism in genetically engineered B cells that express either a single or a combination of IP3R subtypes, and show that Ca2+-signalling patterns depend on the IP3R subtypes, which differ significantly in their response to agonists, i.e. IP3, Ca2+ and ATP.	Inositol 1,4,5-Trisphosphate	129-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	197-201
10064596-3	1999	We have studied the Ca2+-signalling mechanism in genetically engineered B cells that express either a single or a combination of IP3R subtypes, and show that Ca2+-signalling patterns depend on the IP3R subtypes, which differ significantly in their response to agonists, i.e. IP3, Ca2+ and ATP.	Adenosine Triphosphate	289-292	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	197-201
9878054-1	1999	Transmission of cytosolic [Ca2+] ([Ca2+]c) oscillations into the mitochondrial matrix is thought to be supported by local calcium control between IP3 receptor Ca2+ channels (IP3R) and mitochondria, but study of the coupling mechanisms has been difficult.	Calcium	122-129	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	174-178
9878054-6	1999	This architecture explains why calcium oscillations evoked by synchronized periodic activation of IP3R are particularly effective in establishing dynamic control over mitochondrial metabolism.	Calcium	31-38	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-102
9808459-4	1998	A novel proline-rich "Homer ligand" (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain.	Proline	8-15	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-85
9652087-2	1998	Two modes of transmission are found in immature eggs, where the inositol 1,4,5-trisphosphate receptor (IP3R) controls release of calcium from the endoplasmic reticulum (ER).	Calcium	129-136	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	103-107
9688646-6	1998	The contraction induced by CCK was inhibited by the phospholipase C (PLC) inhibitor U-73122, anti-PLC-beta3 antibody, and the IP3 receptor antagonist heparin but was not inhibited by the the phospholipase D inhibitor propranolol or antibodies against PLC-beta1 or PLC-beta2.	Heparin	150-157	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-138
9678515-7	1998	By contrast, the staining pattern of the Purkinje cells of gc-CD case was uniform: almost all the Purkinje cells expressed P400/IP3R in cell bodies, axons and dendrites, but not in the dendritic spines and spiny branchlets.	gc-cd	59-64	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	128-132
9346894-4	1997	We now report that FKBP12 binds the IP3R at residues 1400-1401, a leucyl-prolyl dipeptide epitope that structurally resembles FK506.	Dipeptides	80-89	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	36-40
9586805-9	1998	While the IP3 receptor system is considered to be the main regulator of calcium release, liver also contains a ryanodine-sensitive calcium releasing store.	Calcium	72-79	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	10-22
9346894-4	1997	We now report that FKBP12 binds the IP3R at residues 1400-1401, a leucyl-prolyl dipeptide epitope that structurally resembles FK506.	Tacrolimus	126-131	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	36-40
9376222-13	1997	Furthermore, elevation of cAMP may inhibit IP3 production and [Ca2+]i mobilization through mechanisms involving PKA-dependent phosphorylation of PLC, G-proteins, IP3 receptor and/or IP3 metabolizing enzymes.	Cyclic AMP	26-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	162-174
9218795-0	1997	Minimal requirements for calcium oscillations driven by the IP3 receptor.	Calcium	25-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-72
9268725-2	1997	Here we show that two types of intracellular calcium release channel, the inositol 1,4,5-trisphosphate-gated channel (IP3R) and the ryanodine receptor (RyR) are modulated in an opposing manner by arachidonic acid and its product leukotriene B4 (LTB4).	Leukotriene B4	229-243	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	118-122
9268725-3	1997	The IP3R was inhibited by arachidonic acid (Ki = 27 nM), whereas the RyR was unaffected by this compound.	Arachidonic Acid	26-42	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-8
9268725-2	1997	Here we show that two types of intracellular calcium release channel, the inositol 1,4,5-trisphosphate-gated channel (IP3R) and the ryanodine receptor (RyR) are modulated in an opposing manner by arachidonic acid and its product leukotriene B4 (LTB4).	Arachidonic Acid	196-212	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	118-122
9218795-2	1997	Imaging of fluorescent Ca2+ indicators located within intracellular Ca2+ stores was used to monitor IP3 receptor channel (IP3R) function and to demonstrate that IP3-dependent oscillations of Ca2+ release and re-uptake can be reproduced in single permeabilized hepatocytes.	Inositol 1,4,5-Trisphosphate	100-103	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-126
9218795-4	1997	With IP3 clamped at a submaximal concentration, coordinated cycles of IP3R activation and subsequent inactivation were observed in each cell.	Inositol 1,4,5-Trisphosphate	5-8	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-74
9214625-4	1997	We demonstrate here that B cells in which a single type of IP3R has been deleted still mobilize calcium in response to BCR stimulation, whereas this calcium mobilization is abrogated in B cells lacking all three types of IP3R.	Calcium	96-103	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	59-63
8957234-7	1996	We concluded that CGRP receptor stimulation reduces substance-P-induced O2- production by the inhibition of IP3-induced transient increase in [Ca2+]i, probably via the phosphorylation of IP3 receptor by cAMP-dependent protein kinase.	Superoxides	72-74	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	187-199
9006903-8	1997	These data suggest sequential positive and negative regulation of the hepatic IP3 receptor by cytosolic calcium and by IP3, which may underlie hepatocellular propagation of regenerative, oscillatory calcium signals.	Calcium	104-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-90
9006903-8	1997	These data suggest sequential positive and negative regulation of the hepatic IP3 receptor by cytosolic calcium and by IP3, which may underlie hepatocellular propagation of regenerative, oscillatory calcium signals.	Calcium	199-206	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	78-90
9168020-1	1997	We present a theoretical analysis of intracellular calcium waves propagated by calcium feedback at the inositol 1,4,5-trisphosphate (IP3) receptor.	Calcium	51-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	133-146
9168020-1	1997	We present a theoretical analysis of intracellular calcium waves propagated by calcium feedback at the inositol 1,4,5-trisphosphate (IP3) receptor.	Calcium	79-86	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	133-146
8918899-7	1996	Thus, in several gastrointestinal tissues the Type 3 InsP3 receptor is specifically localized to a portion of the apical cytoskeletal domain in which resides the calcium-responsive effector CaM kinase II.	Calcium	162-169	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	46-67
8957234-7	1996	We concluded that CGRP receptor stimulation reduces substance-P-induced O2- production by the inhibition of IP3-induced transient increase in [Ca2+]i, probably via the phosphorylation of IP3 receptor by cAMP-dependent protein kinase.	Inositol 1,4,5-Trisphosphate	108-111	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	187-199
8957234-7	1996	We concluded that CGRP receptor stimulation reduces substance-P-induced O2- production by the inhibition of IP3-induced transient increase in [Ca2+]i, probably via the phosphorylation of IP3 receptor by cAMP-dependent protein kinase.	Cyclic AMP	203-207	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	187-199
8894271-8	1996	Additionally, IP3R partial agonists were found to exhibit lower intrinsic activity for both activation and inactivation of QCR, suggesting that ligand-induced inactivation of the IP3R was more important than inactivation mechanisms reliant on either Ca2+ flux through the channel and/or calcium store depletion.	Calcium	287-294	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	14-18
8894271-8	1996	Additionally, IP3R partial agonists were found to exhibit lower intrinsic activity for both activation and inactivation of QCR, suggesting that ligand-induced inactivation of the IP3R was more important than inactivation mechanisms reliant on either Ca2+ flux through the channel and/or calcium store depletion.	Calcium	287-294	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	179-183
8679550-9	1996	Immunoprecipitation experiments with 32P(i)-labeled cells provided the first evidence that inositol 1,4,5-trisphosphate receptor (IP3R) was phosphorylated by CaMK II in vivo.	Phosphorus-32	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
8627561-4	1996	Both an IP3 receptor monoclonal antibody (5 micrograms/ml) and an IP3 receptor antagonist, heparin (5 mg/ml), directly introduced into the cells via the patch pipette, reduced or abolished oscillations in Clca induced by ACh.	Heparin	91-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	66-78
8627561-4	1996	Both an IP3 receptor monoclonal antibody (5 micrograms/ml) and an IP3 receptor antagonist, heparin (5 mg/ml), directly introduced into the cells via the patch pipette, reduced or abolished oscillations in Clca induced by ACh.	Acetylcholine	221-224	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	8-20
8901022-6	1996	An IP3 receptor antagonist, heparin, reduced both the substance P-induced O2- production and the transient increase in [Ca2+]i without any significant effects on the sustained increase in [Ca2+]i.	Heparin	28-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	3-15
8901022-6	1996	An IP3 receptor antagonist, heparin, reduced both the substance P-induced O2- production and the transient increase in [Ca2+]i without any significant effects on the sustained increase in [Ca2+]i.	Superoxides	74-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	3-15
7589988-3	1995	One important class of oscillations and waves is dependent on the presence of inositol (1,4,5)-trisphosphate (IP3), which releases Ca2+ from internal stores via the IP3 receptor/Ca2+ channel.	Inositol 1,4,5-Trisphosphate	78-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	165-177
8647892-7	1996	Analysis of the rate of Ca2+ release at various IP3 concentrations indicated a significant shift of the IP3 dose response toward higher [IP3] with decreasing [Ca2+]s. We conclude that IP3-dependent Ca2+ release in HSY cells is a steady-state process wherein Ca2+ efflux via the IP3 receptor Ca2+ channel is regulated by [Ca2+]s, apparently via changes in the sensitivity of the channel to IP3.	Inositol 1,4,5-Trisphosphate	104-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	278-290
8647892-7	1996	Analysis of the rate of Ca2+ release at various IP3 concentrations indicated a significant shift of the IP3 dose response toward higher [IP3] with decreasing [Ca2+]s. We conclude that IP3-dependent Ca2+ release in HSY cells is a steady-state process wherein Ca2+ efflux via the IP3 receptor Ca2+ channel is regulated by [Ca2+]s, apparently via changes in the sensitivity of the channel to IP3.	Inositol 1,4,5-Trisphosphate	104-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	278-290
8647892-7	1996	Analysis of the rate of Ca2+ release at various IP3 concentrations indicated a significant shift of the IP3 dose response toward higher [IP3] with decreasing [Ca2+]s. We conclude that IP3-dependent Ca2+ release in HSY cells is a steady-state process wherein Ca2+ efflux via the IP3 receptor Ca2+ channel is regulated by [Ca2+]s, apparently via changes in the sensitivity of the channel to IP3.	Inositol 1,4,5-Trisphosphate	104-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	278-290
8647892-7	1996	Analysis of the rate of Ca2+ release at various IP3 concentrations indicated a significant shift of the IP3 dose response toward higher [IP3] with decreasing [Ca2+]s. We conclude that IP3-dependent Ca2+ release in HSY cells is a steady-state process wherein Ca2+ efflux via the IP3 receptor Ca2+ channel is regulated by [Ca2+]s, apparently via changes in the sensitivity of the channel to IP3.	Inositol 1,4,5-Trisphosphate	104-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	278-290
8521476-6	1995	We now report that calcineurin is physiologically associated with the IP3R-FKBP12 and RyR-FKBP12 receptor complexes and that this interaction can be disrupted by FK506 or rapamycin.	Tacrolimus	162-167	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-74
8521476-6	1995	We now report that calcineurin is physiologically associated with the IP3R-FKBP12 and RyR-FKBP12 receptor complexes and that this interaction can be disrupted by FK506 or rapamycin.	Sirolimus	171-180	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	70-74
7589988-3	1995	One important class of oscillations and waves is dependent on the presence of inositol (1,4,5)-trisphosphate (IP3), which releases Ca2+ from internal stores via the IP3 receptor/Ca2+ channel.	Inositol 1,4,5-Trisphosphate	110-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	165-177
7642703-9	1995	The IP3R fractionated with acrosomes by discontinuous sucrose gradient centrifugation and was enriched in the medium of acrosome-reacted sperm.	Sucrose	54-61	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-8
7646443-13	1995	The sensitivity of [3H]IP3 binding in permeabilized hepatocytes to varied ratios of GSSG and GSH suggests that the IP3 receptor responds to an oxidized redox environment such as that found in the lumen of the endoplasmic reticulum.	Tritium	20-22	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-127
7646443-13	1995	The sensitivity of [3H]IP3 binding in permeabilized hepatocytes to varied ratios of GSSG and GSH suggests that the IP3 receptor responds to an oxidized redox environment such as that found in the lumen of the endoplasmic reticulum.	Inositol 1,4,5-Trisphosphate	23-26	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-127
7646443-13	1995	The sensitivity of [3H]IP3 binding in permeabilized hepatocytes to varied ratios of GSSG and GSH suggests that the IP3 receptor responds to an oxidized redox environment such as that found in the lumen of the endoplasmic reticulum.	Glutathione Disulfide	84-88	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-127
7646443-13	1995	The sensitivity of [3H]IP3 binding in permeabilized hepatocytes to varied ratios of GSSG and GSH suggests that the IP3 receptor responds to an oxidized redox environment such as that found in the lumen of the endoplasmic reticulum.	Glutathione	93-96	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-127
8074237-5	1994	Monoclonal antibodies to the IP3 receptor abolished both ACh-induced K+ and Cl- currents.	Acetylcholine	57-60	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	29-41
7597070-2	1995	It has been suggested that the second messenger inositol 1,4,5-trisphosphate (IP3) produced after TCR stimulation binds to the IP3 receptor (IP3R), an intracellular Ca(2+)-release channel, and triggers the increase in [Ca2+]i that activates transcription of the gene for T-cell growth factor interleukin 2 (IL-2).	Inositol 1,4,5-Trisphosphate	48-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	127-139
7597070-2	1995	It has been suggested that the second messenger inositol 1,4,5-trisphosphate (IP3) produced after TCR stimulation binds to the IP3 receptor (IP3R), an intracellular Ca(2+)-release channel, and triggers the increase in [Ca2+]i that activates transcription of the gene for T-cell growth factor interleukin 2 (IL-2).	Inositol 1,4,5-Trisphosphate	48-76	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
7597070-2	1995	It has been suggested that the second messenger inositol 1,4,5-trisphosphate (IP3) produced after TCR stimulation binds to the IP3 receptor (IP3R), an intracellular Ca(2+)-release channel, and triggers the increase in [Ca2+]i that activates transcription of the gene for T-cell growth factor interleukin 2 (IL-2).	Inositol 1,4,5-Trisphosphate	78-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	127-139
7597070-2	1995	It has been suggested that the second messenger inositol 1,4,5-trisphosphate (IP3) produced after TCR stimulation binds to the IP3 receptor (IP3R), an intracellular Ca(2+)-release channel, and triggers the increase in [Ca2+]i that activates transcription of the gene for T-cell growth factor interleukin 2 (IL-2).	Inositol 1,4,5-Trisphosphate	78-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
7597070-4	1995	Stable transfection of T cells (Jurkat) with antisense type 1 IP3R cDNA prevented type 1 IP3R expression, providing a tool for dissecting the role of IP3 signaling during T-cell activation.	Inositol 1,4,5-Trisphosphate	62-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-93
7722640-6	1995	The ATP-evoked Ca2+ response was blocked by the IP3 receptor antagonist heparin, applied intracellularly, but not by N-desulfated heparin, which is not an antagonist at these receptors.	Adenosine Triphosphate	4-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-60
7722640-6	1995	The ATP-evoked Ca2+ response was blocked by the IP3 receptor antagonist heparin, applied intracellularly, but not by N-desulfated heparin, which is not an antagonist at these receptors.	Heparin	72-79	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-60
7860772-9	1995	RyR down-regulation could contribute to impaired contractility; IP3R up regulation may be a compensatory response providing an alternative pathway for mobilizing intracellular calcium release, possibly contributing to the increased diastolic tone associated with heart failure and the hypertrophic response of failing myocardium.	Calcium	176-183	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	64-68
8841603-2	1995	The first total synthesis of adenophostin A, a potent IP3-receptor agonist, was accomplished by AgCIO4-gamma-collidine-promoted glycosylation employing 2-O-benzyl-3,4,6-tri-O-acetyl-alpha-D-glucopyranosyl bromide as a glycosyl donor.	adenophostin A	29-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	54-66
8841603-2	1995	The first total synthesis of adenophostin A, a potent IP3-receptor agonist, was accomplished by AgCIO4-gamma-collidine-promoted glycosylation employing 2-O-benzyl-3,4,6-tri-O-acetyl-alpha-D-glucopyranosyl bromide as a glycosyl donor.	agcio4-gamma-collidine	96-118	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	54-66
7961860-3	1994	Using purified IP3 receptor (IP3R) protein reconstituted in vesicles, we demonstrate pronounced stimulation by thimerosal of its Ca2+ channel activity.	Thimerosal	111-121	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	15-27
7961860-3	1994	Using purified IP3 receptor (IP3R) protein reconstituted in vesicles, we demonstrate pronounced stimulation by thimerosal of its Ca2+ channel activity.	Thimerosal	111-121	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	29-33
7961860-4	1994	Effects of thimerosal are dependent on the redox state of the receptor, implying an action of thimerosal on a critical sulfhydryl group(s) of IP3R.	Thimerosal	11-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	142-146
7961860-4	1994	Effects of thimerosal are dependent on the redox state of the receptor, implying an action of thimerosal on a critical sulfhydryl group(s) of IP3R.	Thimerosal	94-104	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	142-146
7961860-5	1994	Thimerosal enhances the affinity of IP3R for IP3 binding.	Thimerosal	0-10	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	36-40
7961860-6	1994	The manner in which thimerosal modulates IP3R responsiveness to IP3 provides evidence for receptor heterogeneity with implications for mechanisms of quantal Ca2+ release.	Thimerosal	20-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	41-45
7994011-1	1994	The molecular, structural and functional characteristics of the intracellular Ca2+ release channel activated by inositol 1,4,5-trisphosphate (IP3), also named IP3 receptor (IP3R), are described here.	Inositol 1,4,5-Trisphosphate	112-140	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-171
7754532-3	1994	It was originally thought that caffeine acts solely as an agonist for the ryanodine receptor and heparin acts solely as an inhibitor for the IP3 receptor.	Heparin	97-104	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-153
7994011-1	1994	The molecular, structural and functional characteristics of the intracellular Ca2+ release channel activated by inositol 1,4,5-trisphosphate (IP3), also named IP3 receptor (IP3R), are described here.	Inositol 1,4,5-Trisphosphate	112-140	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	173-177
7994011-1	1994	The molecular, structural and functional characteristics of the intracellular Ca2+ release channel activated by inositol 1,4,5-trisphosphate (IP3), also named IP3 receptor (IP3R), are described here.	Inositol 1,4,5-Trisphosphate	142-145	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	159-171
7994011-1	1994	The molecular, structural and functional characteristics of the intracellular Ca2+ release channel activated by inositol 1,4,5-trisphosphate (IP3), also named IP3 receptor (IP3R), are described here.	Inositol 1,4,5-Trisphosphate	142-145	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	173-177
7754532-5	1994	In the same concentration range, caffeine activates the ryanodine receptor and inhibits the IP3 receptor, and heparin inhibits the IP3 receptor and activates the ryanodine receptor.	Caffeine	33-41	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	92-104
7754532-5	1994	In the same concentration range, caffeine activates the ryanodine receptor and inhibits the IP3 receptor, and heparin inhibits the IP3 receptor and activates the ryanodine receptor.	Heparin	110-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	131-143
8132598-3	1994	The purified IP3 receptor was phosphorylated using either the cGMP- or cAMP-dependent protein kinase in vitro.	Cyclic GMP	62-66	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	13-25
8132598-8	1994	Vascular smooth muscle cells prelabeled with [32P]orthophosphate and treated with atrial natriuretic peptide or sodium nitroprusside to elevate cGMP also resulted in increased labeling of the IP3 receptor.	Phosphate-32P	45-64	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	192-204
8132598-8	1994	Vascular smooth muscle cells prelabeled with [32P]orthophosphate and treated with atrial natriuretic peptide or sodium nitroprusside to elevate cGMP also resulted in increased labeling of the IP3 receptor.	Nitroprusside	112-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	192-204
8132598-8	1994	Vascular smooth muscle cells prelabeled with [32P]orthophosphate and treated with atrial natriuretic peptide or sodium nitroprusside to elevate cGMP also resulted in increased labeling of the IP3 receptor.	Cyclic GMP	144-148	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	192-204
8132598-9	1994	Phosphorylation of IP3 receptor by cGMP kinase may regulate the function of IP3 receptor in vascular smooth muscle cells and contribute to the effect of cGMP to regulate intracellular calcium levels.	Cyclic GMP	35-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-31
8132598-9	1994	Phosphorylation of IP3 receptor by cGMP kinase may regulate the function of IP3 receptor in vascular smooth muscle cells and contribute to the effect of cGMP to regulate intracellular calcium levels.	Cyclic GMP	35-39	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	76-88
8132598-9	1994	Phosphorylation of IP3 receptor by cGMP kinase may regulate the function of IP3 receptor in vascular smooth muscle cells and contribute to the effect of cGMP to regulate intracellular calcium levels.	Calcium	184-191	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	19-31
8081734-4	1994	COS-7 cells transfected with human type 3 IP3R showed characteristic inositol 1,4,5-trisphosphate (IP3)-binding properties with Kd values of 28.8 nM.	carbonyl sulfide	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-46
8137917-4	1994	Therefore, the pH-dependent potential interaction of the intraluminal loop domains of the IP3 receptor with chromogranin A was studied by analytical ultracentrifugation utilizing synthetic intraluminal loop peptides of the IP3 receptor labeled with 5-hydroxy-tryptophan at the N-terminus as a chromophore.	5-Hydroxytryptophan	249-269	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-102
8115665-14	1994	There is suggestive evidence linking the PI system, and thus the IP3R, to bipolar disorder and the actions of lithium.	Lithium	110-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-69
8081734-4	1994	COS-7 cells transfected with human type 3 IP3R showed characteristic inositol 1,4,5-trisphosphate (IP3)-binding properties with Kd values of 28.8 nM.	Inositol 1,4,5-Trisphosphate	69-97	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-46
8385671-8	1993	Evidence for IP3-sensitive Ca2+ stores in Purkinje myocytes was obtained by double immunolabeling experiments for IP3 receptor and cardiac calsequestrin, the sarcoplasmic reticulum intralumenal calcium binding protein.	Inositol 1,4,5-Trisphosphate	13-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	114-126
8279519-2	1993	Extraction of the membranes with the nonionic detergents Nonidet P-40 and Triton X-100, followed by centrifugation at 100,000 g, resulted in the doubling of the IP3 receptor in the pellets, whereas no detectable binding was found in the supernatants.	Nonidet P-40	57-69	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	161-173
8279519-2	1993	Extraction of the membranes with the nonionic detergents Nonidet P-40 and Triton X-100, followed by centrifugation at 100,000 g, resulted in the doubling of the IP3 receptor in the pellets, whereas no detectable binding was found in the supernatants.	Octoxynol	74-86	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	161-173
8279519-13	1993	Because cytochalasin D treatment of livers diminishes the ability of IP3 to raise cytosolic free Ca2+ levels, the attachment of the IP3 receptor to the cytoskeleton seems to involve an association with microfilaments.	Inositol 1,4,5-Trisphosphate	69-72	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	132-144
8263781-8	1993	The IP3 receptor antagonist heparin, and depletion of intracellular Ca++ stores by thapsigargin or A23187, inhibited ACh-induced contraction of LES but not of esophageal muscle.	Heparin	28-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-16
8263781-8	1993	The IP3 receptor antagonist heparin, and depletion of intracellular Ca++ stores by thapsigargin or A23187, inhibited ACh-induced contraction of LES but not of esophageal muscle.	Acetylcholine	117-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-16
8274628-0	1993	Calcium oscillations and waves: is the IP3R Ca2+ channel the culprit?	Calcium	0-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	39-43
8270909-19	1993	Intracellular application of heparin or of the monoclonal antibody against the IP3 receptor, mAb18A10, inhibited the ACh and His responses in a concentration-dependent fashion.	Heparin	29-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-91
8270909-19	1993	Intracellular application of heparin or of the monoclonal antibody against the IP3 receptor, mAb18A10, inhibited the ACh and His responses in a concentration-dependent fashion.	Acetylcholine	117-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-91
8292501-1	1993	This review focuses on the action of intracellular magnesium ion on the inositol 1,4,5-trisphosphate (IP3) receptor, the almost ubiquitous membrane-bound Ca2+ channel gated by the intracellular second messenger IP3.	Magnesium	51-60	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	102-115
8252824-6	1993	After frozen brains were cut into serial slices on a cryostat, the IP3 receptor binding was evaluated in vitro by using 3H-inositol 1,4,5-trisphosphate as the ligand.	3h-inositol 1,4,5-trisphosphate	120-151	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	67-79
7686381-2	1993	The effects of ATP on the IP3 receptor at the single-channel level were characterized after channel incorporation into planar lipid bilayers.	Adenosine Triphosphate	15-18	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	26-38
8447814-5	1993	Protein kinase C (PKC) inhibitor H7 (200 nM), calcium channel blocker verapamil (10 microM), or IP3 receptor antagonist ryonidine (5 microM) reduced ET-1 (100 nM)-induced release of 51Cr.	ryonidine	120-129	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	96-108
8382518-6	1993	A single purified [3H]BZDC-IP3-labeled peptide, corresponding to IP3R amino acids 476-501, was sequenced and shown to match specific sequences in the N-terminal 20% of the IP3 receptor, an area suggested on the basis of mutagenesis studies to contain the IP3 recognition site.	Tritium	19-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-69
8382518-3	1993	The high specific activity of [125I]ASA-IP3 allowed identification of a single photolabeling site within the IP3R by two-dimensional peptide analysis.	asa-ip3	36-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
8382518-2	1993	Both ligands have high affinity for the IP3 receptor and, when photoactivated, label the IP3 receptor protein with appropriate inositol phosphate selectivity.	Inositol Phosphates	127-145	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	40-52
8382518-6	1993	A single purified [3H]BZDC-IP3-labeled peptide, corresponding to IP3R amino acids 476-501, was sequenced and shown to match specific sequences in the N-terminal 20% of the IP3 receptor, an area suggested on the basis of mutagenesis studies to contain the IP3 recognition site.	Tritium	19-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-184
8382518-2	1993	Both ligands have high affinity for the IP3 receptor and, when photoactivated, label the IP3 receptor protein with appropriate inositol phosphate selectivity.	Inositol Phosphates	127-145	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-101
8382518-6	1993	A single purified [3H]BZDC-IP3-labeled peptide, corresponding to IP3R amino acids 476-501, was sequenced and shown to match specific sequences in the N-terminal 20% of the IP3 receptor, an area suggested on the basis of mutagenesis studies to contain the IP3 recognition site.	Inositol 1,4,5-Trisphosphate	26-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-69
8382518-6	1993	A single purified [3H]BZDC-IP3-labeled peptide, corresponding to IP3R amino acids 476-501, was sequenced and shown to match specific sequences in the N-terminal 20% of the IP3 receptor, an area suggested on the basis of mutagenesis studies to contain the IP3 recognition site.	Inositol 1,4,5-Trisphosphate	26-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-184
8382518-6	1993	A single purified [3H]BZDC-IP3-labeled peptide, corresponding to IP3R amino acids 476-501, was sequenced and shown to match specific sequences in the N-terminal 20% of the IP3 receptor, an area suggested on the basis of mutagenesis studies to contain the IP3 recognition site.	Inositol 1,4,5-Trisphosphate	27-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	65-69
8382518-6	1993	A single purified [3H]BZDC-IP3-labeled peptide, corresponding to IP3R amino acids 476-501, was sequenced and shown to match specific sequences in the N-terminal 20% of the IP3 receptor, an area suggested on the basis of mutagenesis studies to contain the IP3 recognition site.	Inositol 1,4,5-Trisphosphate	27-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-184
1313570-1	1992	The inositol 1,4,5-trisphosphate receptor (IP3R) associated with plasma membranes of lymphocytes differs in terminal sugar content and binding specificity from the cerebellar receptor, which is localized to endoplasmic reticulum.	Sugars	117-122	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	43-47
1313030-2	1992	The IP3 receptor is regulated by ATP, calcium, and phosphorylation by protein kinase A, protein kinase C, and calcium/calmodulin-dependent protein kinase II.	Adenosine Triphosphate	33-36	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-16
1313030-2	1992	The IP3 receptor is regulated by ATP, calcium, and phosphorylation by protein kinase A, protein kinase C, and calcium/calmodulin-dependent protein kinase II.	Calcium	38-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-16
1313030-3	1992	Its cDNA sequence predicts at least two consensus sequences where nucleotides might bind, and direct binding of ATP to the IP3 receptor has been demonstrated.	Adenosine Triphosphate	112-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	123-135
1313030-4	1992	In the present study, we demonstrate autophosphorylation of the purified and reconstituted IP3 receptor on serine and find serine protein kinase activity of the IP3 receptor toward a specific peptide substrate.	Serine	107-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	91-103
1411526-2	1992	To investigate this difference in Ca2+ signaling, airway epithelial cells were loaded with heparin, an inositol 1,4,5-triphosphate (IP3) receptor antagonist, by pulsed, high-frequency electroporation.	Heparin	91-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	132-145
1313570-2	1992	Lectin column chromatography reveals that 30% of IP3R in the thymus contains sialic acid, reflecting a plasma membrane association, in contrast to 5% of cerebellar IP3R.	N-Acetylneuraminic Acid	77-88	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
1313570-4	1992	The plasma membrane IP3R has lower affinity for IP3 but higher affinity for inositol 1,3,4,5-tetrakisphosphate, which may reflect a unique regulation of calcium at the plasma membrane by inositol phosphates.	inositol-1,3,4,5-tetrakisphosphate	76-110	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-24
1313570-4	1992	The plasma membrane IP3R has lower affinity for IP3 but higher affinity for inositol 1,3,4,5-tetrakisphosphate, which may reflect a unique regulation of calcium at the plasma membrane by inositol phosphates.	Inositol Phosphates	187-206	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-24
1894597-4	1991	This product has the biological characteristics of cADPR (it acts after depletion of the IP3 stores and after blockade of the IP3 receptor by heparin).	Heparin	142-149	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	126-138
15351206-9	2004	Together, these data indicate that A2A receptor activation increases protein phosphatase activity, which blocks IP3 receptor-regulated calcium release and reduction of intracellular calcium inhibits TNF-alpha production in monocytes.	Calcium	135-142	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-124
1848697-5	1991	Phosphorylation by PKC, which is stimulated by Ca2+ and diacylglycerol, and by CaM kinase II, which requires Ca2+, provides means whereby Ca2+ and diacylglycerol, formed during inositol phospholipid turnover, may regulate IP3 receptor physiology.	Diglycerides	147-161	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	222-234
1848697-5	1991	Phosphorylation by PKC, which is stimulated by Ca2+ and diacylglycerol, and by CaM kinase II, which requires Ca2+, provides means whereby Ca2+ and diacylglycerol, formed during inositol phospholipid turnover, may regulate IP3 receptor physiology.	Phosphatidylinositols	177-198	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	222-234
33811561-9	2021	Interestingly, by using both IP3R and VDAC inhibitors, a close cause-effect relationship between mitochondrial Ca2+ overload and ROS generation was evidenced.	ros	129-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	29-33
34748972-8	2022	A Ca2+-free medium and PLC inhibitor caused significant decreases in ET-1-induced lipolysis as well as ERK and HSL phosphorylation, and IP3 receptor activator (D-IP3) increased lipolysis.	d-ip3	160-165	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-148
34884629-6	2021	The generation of these Ca2+ signals by astrocytes occurs through the release of Ca2+ ions from the endoplasmic reticulum through the IP3 receptor upon activation of the phosphoinositide signaling pathway.	Phosphatidylinositols	170-186	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	134-146
34520633-10	2022	Most hepatocytes also expressed inositol 1,4,5-triphosphate receptor 3 (ITPR3), a calcium channel that becomes expressed in acute liver injury.	Calcium	82-89	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	32-70
34520633-10	2022	Most hepatocytes also expressed inositol 1,4,5-triphosphate receptor 3 (ITPR3), a calcium channel that becomes expressed in acute liver injury.	Calcium	82-89	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	72-77
34388674-6	2021	The up-regulation of Ca2+ was induced by inositol triphosphate (IP3) via its specific IP3 receptor.	Inositol triphosphate	41-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-98
34388674-6	2021	The up-regulation of Ca2+ was induced by inositol triphosphate (IP3) via its specific IP3 receptor.	Inositol 1,4,5-Trisphosphate	64-67	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-98
34839371-6	2022	Plethora of signaling cascades are defined including Src-Ras-MAPK signaling, IP3R-mediated calcium oscillation, inflammation, and autophagy though most underlying mechanisms remain elusive.	Calcium	91-98	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	77-81
34592660-0	2021	Mannan-binding lectin deficiency augments hepatic endoplasmic reticulum stress through IP3R-controlled calcium release.	Calcium	103-110	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	87-91
34592660-6	2021	Moreover, MBL deficiency led to enhanced activation of the PERK-C/EBP-homologous protein (CHOP) pathway and initiates an inositol 1,4,5-trisphosphate receptor (IP3R)-mediated calcium release from the ER, thereby aggravating the hepatic ER stress response.	Calcium	175-182	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	160-164
34884798-1	2021	Inositol 1, 4, 5-trisphosphate receptor (IP3R)-mediated Ca2+ signaling plays a pivotal role in different cellular processes, including cell proliferation and cell death.	inositol 1, 4,	0-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	41-45
34884798-1	2021	Inositol 1, 4, 5-trisphosphate receptor (IP3R)-mediated Ca2+ signaling plays a pivotal role in different cellular processes, including cell proliferation and cell death.	-trisphosphate	16-30	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	41-45
34884798-5	2021	Our pharmacophore model illuminates the existence of two hydrogen-bond acceptors (2.62 A and 4.79 A) and two hydrogen-bond donors (5.56 A and 7.68 A), respectively, from a hydrophobic group within the chemical scaffold, which may enhance the liability (IC50) of a compound for IP3R inhibition.	Hydrogen	57-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	277-281
34884798-5	2021	Our pharmacophore model illuminates the existence of two hydrogen-bond acceptors (2.62 A and 4.79 A) and two hydrogen-bond donors (5.56 A and 7.68 A), respectively, from a hydrophobic group within the chemical scaffold, which may enhance the liability (IC50) of a compound for IP3R inhibition.	Hydrogen	109-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	277-281
34884798-6	2021	Moreover, our GRIND model (PLS: Q2 = 0.70 and R2 = 0.72) further strengthens the identified pharmacophore features of IP3R modulators by probing the presence of complementary hydrogen-bond donor and hydrogen-bond acceptor hotspots at a distance of 7.6-8.0 A and 6.8-7.2 A, respectively, from a hydrophobic hotspot at the virtual receptor site (VRS).	Hydrogen	175-183	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	118-122
34884798-6	2021	Moreover, our GRIND model (PLS: Q2 = 0.70 and R2 = 0.72) further strengthens the identified pharmacophore features of IP3R modulators by probing the presence of complementary hydrogen-bond donor and hydrogen-bond acceptor hotspots at a distance of 7.6-8.0 A and 6.8-7.2 A, respectively, from a hydrophobic hotspot at the virtual receptor site (VRS).	Hydrogen	199-207	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	118-122
34827667-3	2021	These changes lead to alterations in the translocation of the MAM components, such as IP3R, VDAC, and MFN1 and 2, and consequently disrupt calcium homeostasis and cause misfolded proteins with impaired autophagy, distorted mitochondrial dynamics, and cell death.	Calcium	139-146	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-90
34685684-3	2021	Here, using biophysical, biochemical, pharmaceutical, and genetic approaches, we show that apoptotic cells induced the Orai1-STIM1 interaction, leading to store-operated calcium entry (SOCE) in phagocytes through the Mertk-phospholipase C (PLC) gamma1-inositol 1,4,5-triphosphate receptor (IP3R) axis.	Calcium	170-177	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	290-294
34400171-1	2021	Recently, a functional IP3R ortholog (CO.IP3R-A) capable of IP3-induced Ca2+ release has been discovered in Capsaspora owczarzaki, a close unicellular relative to Metazoa.	Inositol 1,4,5-Trisphosphate	60-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	23-27
34400171-1	2021	Recently, a functional IP3R ortholog (CO.IP3R-A) capable of IP3-induced Ca2+ release has been discovered in Capsaspora owczarzaki, a close unicellular relative to Metazoa.	Inositol 1,4,5-Trisphosphate	60-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	41-45
34400171-5	2021	We demonstrate that human Bcl-2 via its BH4 domain could functionally interact with CO.IP3R-A, thereby suppressing Ca2+ flux through CO.IP3R-A channels.	sapropterin	40-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	136-140
34400171-6	2021	The BH4 domain of Bcl-2 was sufficient for interaction with CO.IP3R-A channels.	sapropterin	4-7	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
34400171-7	2021	Moreover, mutating the Lys17 of Bcl-2"s BH4 domain, the residue critical for Bcl-2-dependent modulation of mammalian IP3Rs, abrogated Bcl-2"s ability to bind and inhibit CO.IP3R-A channels.	sapropterin	40-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	173-177
34089843-5	2021	Arsenite induced a slow and limited mobilization of Ca2+ from IP3R via a saturable mechanism, failing to increase the (Ca2+)m. This effect was however associated with the triggering of an intraluminal crosstalk between the IP3R and the ryanodine receptor (RyR), causing a large and concentration dependent release of Ca2+ from RyR and a parallel increase in (Ca2+)m. Thus, the Ca2+-dependent mitoO2-.	arsenite	0-8	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-66
34089843-7	2021	We also speculate on the possibility that the ER stress response might regulate the above effects on the intraluminal crosstalk between the IP3R and the RyR via oxidation of critical thiols mediated by the H2O2 locally released by oxidoreductin 1alpha.	Sulfhydryl Compounds	183-189	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-144
34089843-7	2021	We also speculate on the possibility that the ER stress response might regulate the above effects on the intraluminal crosstalk between the IP3R and the RyR via oxidation of critical thiols mediated by the H2O2 locally released by oxidoreductin 1alpha.	Hydrogen Peroxide	206-210	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-144
34685684-6	2021	In addition, the depletion of Mertk, which indirectly senses phosphatidylserine on apoptotic cells, reduced the phosphorylation levels of PLCgamma1 and IP3R, resulting in attenuation of the Orai1-STIM1 interaction and inefficient SOCE upon apoptotic cell stimulation.	Phosphatidylserines	61-79	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	152-156
34750538-6	2022	Single-channel recordings demonstrate that purified Bcl-xL, but not Bcl-xLK87D, suppressed IP3R single-channel openings stimulated by sub-maximal and threshold (IP3).	Inositol 1,4,5-Trisphosphate	161-164	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	91-95
34734188-5	2021	We found that TRPM4 currents activated by stretching the plasma membrane or directly activating IP3Rs were suppressed by exogenous NO or a membrane-permeable cGMP analog, the latter of which also impaired IP3R-mediated release of Ca2+ from the SR.	Cyclic GMP	158-162	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	205-209
34734188-9	2021	We conclude that NO/cGMP/PKG signaling through IRAG inhibits IP3R-dependent activation of TRPM4 channels in SMCs to dilate arteries.	Cyclic GMP	20-24	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-65
34516972-7	2021	Cd-induced MTTP protein and TG levels were significantly reduced by pretreatments of BAPTA/AM chelation of intracellular Ca2+, 2-APB inhibition of ER Ca2+ release channel inositol 1,4,5-trisphosphate receptor (IP3R) and CDN1163 activation of ER Ca2+ reuptake pump sarcoplasmic reticulum Ca2+-ATPase (SERCA).	Cadmium	0-2	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	210-214
34415786-5	2021	The quantitative measurement of FKBP interactions was performed using a cell model with a specific G protein-coupled receptor, as FKBPs had been known to act at the inositol 1,4,5-trisphosphate receptor (IP3R) leading to the inhibition of intracellular calcium mobilization.	Calcium	253-260	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	204-208
34516972-7	2021	Cd-induced MTTP protein and TG levels were significantly reduced by pretreatments of BAPTA/AM chelation of intracellular Ca2+, 2-APB inhibition of ER Ca2+ release channel inositol 1,4,5-trisphosphate receptor (IP3R) and CDN1163 activation of ER Ca2+ reuptake pump sarcoplasmic reticulum Ca2+-ATPase (SERCA).	2-aminoethoxydiphenyl borate	127-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	210-214
35598692-7	2022	Heparin and Xe-C, which are IP3 receptor antagonists, also totally abolished the pilocarpine effect.	xe-c	12-16	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-40
34327909-7	2021	RT-qPCR results of 6 calcium transport-related genes showed that the overexpression of the C-terminal half of the ITPR1 gene significantly inhibited the expression of the IP3R2, VDAC2 and CAV1 genes, and the overexpression of the N-terminal half of the ITPR1 gene significantly promoted the expression of the IP3R3 and CACNA2D1 genes.	Calcium	21-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	309-314
35421768-0	2022	Endoplasmic reticulum-mitochondria coupling attenuates vanadium-induced apoptosis via IP3R in duck renal tubular epithelial cells.	Vanadium	55-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-90
34569666-7	2021	We exposed in vitro acetoacetate-treated PBMCs to the specific IP3R inhibitor Xestospongin B (XeB) to reduce IP3R-mediated mitochondrial Ca2+ accumulation.	acetoacetic acid	20-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
34569666-7	2021	We exposed in vitro acetoacetate-treated PBMCs to the specific IP3R inhibitor Xestospongin B (XeB) to reduce IP3R-mediated mitochondrial Ca2+ accumulation.	acetoacetic acid	20-32	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
34569666-7	2021	We exposed in vitro acetoacetate-treated PBMCs to the specific IP3R inhibitor Xestospongin B (XeB) to reduce IP3R-mediated mitochondrial Ca2+ accumulation.	xestospongin B	78-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
34569666-7	2021	We exposed in vitro acetoacetate-treated PBMCs to the specific IP3R inhibitor Xestospongin B (XeB) to reduce IP3R-mediated mitochondrial Ca2+ accumulation.	xestospongin B	78-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
34569666-7	2021	We exposed in vitro acetoacetate-treated PBMCs to the specific IP3R inhibitor Xestospongin B (XeB) to reduce IP3R-mediated mitochondrial Ca2+ accumulation.	xestospongin B	94-97	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	63-67
34569666-7	2021	We exposed in vitro acetoacetate-treated PBMCs to the specific IP3R inhibitor Xestospongin B (XeB) to reduce IP3R-mediated mitochondrial Ca2+ accumulation.	xestospongin B	94-97	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	109-113
34212292-1	2021	Mitochondrial-associated endoplasmic reticulum (ER) membranes (MAMs) regulate calcium (Ca2+) homeostasis via Ca2+ transport-related proteins such as inositol-1,4,5-triphosphate receptor (IP3R).	Calcium	78-85	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	187-191
34360859-7	2021	At the level of intracellular signaling, the generation of Ca2+ oscillations in white adipocytes in response to a decrease in (Ca2+)ex occurred due to the mobilization of the Ca2+ ions from the thapsigargin-sensitive Ca2+ pool of IP3R as a result of activation of the purinergic P2Y1 receptors and phosphoinositide signaling pathway.	Thapsigargin	194-206	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	230-234
34360859-7	2021	At the level of intracellular signaling, the generation of Ca2+ oscillations in white adipocytes in response to a decrease in (Ca2+)ex occurred due to the mobilization of the Ca2+ ions from the thapsigargin-sensitive Ca2+ pool of IP3R as a result of activation of the purinergic P2Y1 receptors and phosphoinositide signaling pathway.	Phosphatidylinositols	298-314	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	230-234
34472451-6	2021	Intracellular Ca2+ release triggered by GLA was suppressed by 3 muM xestospongin C (XeC, IP3 receptor-channel blocker) and 100 muM ryanodine (ryanodine receptor-channel blocker), suggesting that the Ca2+ release was via IP3 receptor-channel and ryanodine receptor-channel.	gamma-Linolenic Acid	40-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-101
34472451-6	2021	Intracellular Ca2+ release triggered by GLA was suppressed by 3 muM xestospongin C (XeC, IP3 receptor-channel blocker) and 100 muM ryanodine (ryanodine receptor-channel blocker), suggesting that the Ca2+ release was via IP3 receptor-channel and ryanodine receptor-channel.	gamma-Linolenic Acid	40-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	220-232
34472451-6	2021	Intracellular Ca2+ release triggered by GLA was suppressed by 3 muM xestospongin C (XeC, IP3 receptor-channel blocker) and 100 muM ryanodine (ryanodine receptor-channel blocker), suggesting that the Ca2+ release was via IP3 receptor-channel and ryanodine receptor-channel.	xestospongin C	68-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	89-101
34472451-6	2021	Intracellular Ca2+ release triggered by GLA was suppressed by 3 muM xestospongin C (XeC, IP3 receptor-channel blocker) and 100 muM ryanodine (ryanodine receptor-channel blocker), suggesting that the Ca2+ release was via IP3 receptor-channel and ryanodine receptor-channel.	xestospongin C	68-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	220-232
34472451-6	2021	Intracellular Ca2+ release triggered by GLA was suppressed by 3 muM xestospongin C (XeC, IP3 receptor-channel blocker) and 100 muM ryanodine (ryanodine receptor-channel blocker), suggesting that the Ca2+ release was via IP3 receptor-channel and ryanodine receptor-channel.	Ryanodine	131-140	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	220-232
34472451-11	2021	GLA-induced Ca2+ store depletion resulted from opening of IP3 receptor-channel and ryanodine receptor-channel.	gamma-Linolenic Acid	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-70
35598692-7	2022	Heparin and Xe-C, which are IP3 receptor antagonists, also totally abolished the pilocarpine effect.	Pilocarpine	81-92	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	28-40
35487218-0	2022	Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization.	Calcium	43-50	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	37-42
35634274-9	2022	Mechanistically, experiments confirmed the involvement of PLC/Ca2+ since inhibition of PLC or 1,4,5-trisphosphate (IP3) receptor to reduce cytosolic Ca2+ reverted the effects of PF-IgG on Dsg1 intra-membrane mobility and localization.	1,4,5-trisphosphate	94-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-128
35487218-4	2022	ITPR3 is a caffeine-sensitive inositol 1,4,5-triphosphate (IP3) receptor that releases calcium from the endoplasmic reticulum and enhanced metastatic colonization by inducing expression of RELB, a transcription factor that is associated with non-canonical NF-kappaB signaling.	Caffeine	11-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-5
35487218-4	2022	ITPR3 is a caffeine-sensitive inositol 1,4,5-triphosphate (IP3) receptor that releases calcium from the endoplasmic reticulum and enhanced metastatic colonization by inducing expression of RELB, a transcription factor that is associated with non-canonical NF-kappaB signaling.	Inositol 1,4,5-Trisphosphate	30-57	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-5
35487218-4	2022	ITPR3 is a caffeine-sensitive inositol 1,4,5-triphosphate (IP3) receptor that releases calcium from the endoplasmic reticulum and enhanced metastatic colonization by inducing expression of RELB, a transcription factor that is associated with non-canonical NF-kappaB signaling.	Inositol 1,4,5-Trisphosphate	59-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-5
35487218-4	2022	ITPR3 is a caffeine-sensitive inositol 1,4,5-triphosphate (IP3) receptor that releases calcium from the endoplasmic reticulum and enhanced metastatic colonization by inducing expression of RELB, a transcription factor that is associated with non-canonical NF-kappaB signaling.	Calcium	87-94	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-5
35339877-4	2022	We found that excessive Cu disrupted MAM integrity, decreased the mitochondrial calcium level, co-localization of IP3R and VDAC1, the mRNA levels of PACS2, Mfn2, IP3R and MCU, and Mfn2 and VDAC1 protein levels, causing MAM dysfunction.	Copper	24-26	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	114-118
35367758-3	2022	Here we found that GBM cells treated with cytotoxic concentrations of NNC-55-0396 paradoxically increased cytosolic calcium levels through the activation of inositol triphosphate receptors (IP3R) and ER stress.	NNC 55-0396	70-81	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	190-194
35367758-3	2022	Here we found that GBM cells treated with cytotoxic concentrations of NNC-55-0396 paradoxically increased cytosolic calcium levels through the activation of inositol triphosphate receptors (IP3R) and ER stress.	Calcium	116-123	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	190-194
35367758-5	2022	Calcium chelation or IP3R inhibition prevented NNC-55-0396-mediated cytotoxicity, indicating that ER calcium efflux is the cause of cell death.	NNC 55-0396	47-58	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	21-25
35367758-5	2022	Calcium chelation or IP3R inhibition prevented NNC-55-0396-mediated cytotoxicity, indicating that ER calcium efflux is the cause of cell death.	Calcium	101-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	21-25
35496076-0	2022	Protodioscin Induces Mitochondrial Apoptosis of Human Hepatocellular Carcinoma Cells Through Eliciting ER Stress-Mediated IP3R Targeting Mfn1/Bak Expression.	protodioscin	0-12	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-126
35496076-0	2022	Protodioscin Induces Mitochondrial Apoptosis of Human Hepatocellular Carcinoma Cells Through Eliciting ER Stress-Mediated IP3R Targeting Mfn1/Bak Expression.	bakuchiol	142-145	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	122-126
35235701-5	2022	RESULTS: LPS induced the release of Exo in a TLR4-dependent manner in vitro, which effect can be partly abrogated by an membrane-permeable IP 3 R antagonist, 2-aminoethyl diphenylborinate (2-APB), but not PLC inhibitor, U-73122.	2-aminoethyl diphenylborinate	158-187	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-145
35235701-5	2022	RESULTS: LPS induced the release of Exo in a TLR4-dependent manner in vitro, which effect can be partly abrogated by an membrane-permeable IP 3 R antagonist, 2-aminoethyl diphenylborinate (2-APB), but not PLC inhibitor, U-73122.	2-aminoethyl diphenylborinate	189-194	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-145
35235701-5	2022	RESULTS: LPS induced the release of Exo in a TLR4-dependent manner in vitro, which effect can be partly abrogated by an membrane-permeable IP 3 R antagonist, 2-aminoethyl diphenylborinate (2-APB), but not PLC inhibitor, U-73122.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	220-227	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	139-145
35496076-8	2022	Further analysis revealed that Mfn1 and Bak will form a complex with IP3R to facilitate the transfer of Ca2+ from ER to mitochondria and apoptosis.	bakuchiol	40-43	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	69-73
35339877-4	2022	We found that excessive Cu disrupted MAM integrity, decreased the mitochondrial calcium level, co-localization of IP3R and VDAC1, the mRNA levels of PACS2, Mfn2, IP3R and MCU, and Mfn2 and VDAC1 protein levels, causing MAM dysfunction.	Copper	24-26	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	162-166
35269695-1	2022	Calcium homeostasis endoplasmic reticulum protein (CHERP) is colocalized with the inositol 1,4,5-trisphosphate receptor (IP3R) in the endoplasmic reticulum or perinuclear region, and has been involved in intracellular calcium signaling.	Calcium	218-225	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	121-125
35494252-4	2022	Both IP3R-triple-knockout (IP3R-TKO) and calcineurin inhibition dramatically suppress the metabolic switch in oxidative phosphorylation and glycolysis of stimulated B cells through regulation of glucose uptake, glycolytic enzyme expression, and mitochondrial remodeling, leading to impaired cell-cycle entry and survival.	Glucose	195-202	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	5-9
35494252-4	2022	Both IP3R-triple-knockout (IP3R-TKO) and calcineurin inhibition dramatically suppress the metabolic switch in oxidative phosphorylation and glycolysis of stimulated B cells through regulation of glucose uptake, glycolytic enzyme expression, and mitochondrial remodeling, leading to impaired cell-cycle entry and survival.	Glucose	195-202	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	27-31
35220394-3	2022	Transmission electron microscopy, proximity ligation assays for mitochondrial VDAC1 and endoplasmic reticulum IP3R, and immunoanalyses of p-DRP1 and OPA1, demonstrate that low-oxygen conditions in early 1st trimester and PE promote mitochondrial fission in pMSCs.	Oxygen	176-182	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	110-114
35266886-0	2022	3,3"-Diindolylmethane induces ferroptosis by BAP1-IP3R axis in BGC-823 gastric cancer cells.	3,3'-diindolylmethane	0-21	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	50-54
35189109-1	2022	Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO2-.) via a Ca2+-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IP3R) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca2+ to the mitochondria.	arsenite	0-8	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	240-244
35189109-1	2022	Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO2-.) via a Ca2+-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IP3R) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca2+ to the mitochondria.	Superoxides	106-116	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	240-244
35189109-1	2022	Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO2-.) via a Ca2+-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IP3R) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca2+ to the mitochondria.	mitoo2-.	118-126	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	240-244
35189109-1	2022	Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO2-.) via a Ca2+-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IP3R) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca2+ to the mitochondria.	Inositol 1,4,5-Trisphosphate	199-229	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	240-244
35300350-6	2021	Caffeine can also directly inhibit IP3R3, p38 phosphorylation, and rho-associated protein kinase (ROCK), decreasing cell invasion and migration capacity or indirectly by inhibiting the tissue inhibitor metalloproteinase-1 (TIMP-1) and integrins beta1 and beta3, leading to lower matrix metalloproteinases, MMP-2 and MMP-9.	Caffeine	0-8	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-40
35159324-6	2022	Interestingly, in Mfn2 knock-down cells, the inhibition of the inositol 1,4,5-trisphosphate receptor (IP3R) and the mitochondrial calcium (Ca2+) uniporter (MCU) restored vesicle protein content and attenuated exocytosis.	Inositol 1,4,5-Trisphosphate	63-91	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	102-106
35211031-8	2022	Endothelial cell IP3R- and TRPV4-mediated Ca2+ signals also control the production of endothelial cell vasodilator autacoids, such as NO, PGI2, and epoxides of arachidonic acid contributing to control of overlying vascular smooth muscle contractile activity.	Epoprostenol	138-142	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	17-21
35211031-8	2022	Endothelial cell IP3R- and TRPV4-mediated Ca2+ signals also control the production of endothelial cell vasodilator autacoids, such as NO, PGI2, and epoxides of arachidonic acid contributing to control of overlying vascular smooth muscle contractile activity.	Epoxy Compounds	148-156	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	17-21
35211031-8	2022	Endothelial cell IP3R- and TRPV4-mediated Ca2+ signals also control the production of endothelial cell vasodilator autacoids, such as NO, PGI2, and epoxides of arachidonic acid contributing to control of overlying vascular smooth muscle contractile activity.	Arachidonic Acid	160-176	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	17-21
35163507-7	2022	As a result, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) production were increased significantly by artesunate relative to the doses, as well as phosphorylated vasodilator-stimulated phosphoprotein (VASP) and inositol 1,4,5-trisphosphate receptor (IP3R), substrates to cAMP-dependent kinase and cGMP-dependent kinase, in a significant manner.	Artesunate	136-146	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	284-288
35051621-4	2022	We first found that post-training administration of the IP3R antagonist 2-aminoethyl diphenylborinate (2-APB) impaired memory consolidation in a dose and time-dependent manner.	2-aminoethyl diphenylborinate	72-101	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-60
35051621-4	2022	We first found that post-training administration of the IP3R antagonist 2-aminoethyl diphenylborinate (2-APB) impaired memory consolidation in a dose and time-dependent manner.	2-aminoethyl diphenylborinate	103-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-60
35163507-8	2022	The Ca2+, normally mobilized from the dense tubular system, was inhibited due to IP3R phosphorylation from artesunate, and phosphorylated VASP aided in inhibiting platelet activity via alphaIIb/beta3 platelet membrane inactivation and inhibiting fibrinogen binding.	Artesunate	107-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-85
35022238-9	2022	Enhancing, or decreasing, IP3R function at ambient (IP3) causes corresponding increase, or attenuation, of immobile STIM2 clusters.	Inositol 1,4,5-Trisphosphate	52-55	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	26-30
35022238-11	2022	Finally, under basal conditions, ambient PIP2-PLC activity of the cell determines IP3R function, immobilization of STIM2, and basal Ca2+ entry while agonist stimulation augments these processes.	Phosphatidylinositol 4,5-Diphosphate	41-45	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-86
35328381-5	2022	The IP3Rs (and particularly the IP3R3 subtype) are known to be involved in proliferation, migration, and invasion processes in breast cancer cell lines.	ip3rs	4-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	32-37