PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
16348081-1	1989	A simple and rapid method was developed to detect beta-galactosidase by using alpha- or beta-naphthyl-beta-d-galactopyranoside as substrate and fast garnet GBC as a dye coupler following polyacrylamide gel electrophoresis.	alpha- or beta-naphthyl-beta-d-galactopyranoside	78-126	galactosidase beta 1	Homo sapiens	50-68
2558971-4	1989	Stable transformants induced with dexamethasone, a synthetic glucocorticoid hormone, demonstrated beta-galactosidase activity 60-140-fold higher than uninduced controls.	Dexamethasone	34-47	galactosidase beta 1	Homo sapiens	98-116
16348081-1	1989	A simple and rapid method was developed to detect beta-galactosidase by using alpha- or beta-naphthyl-beta-d-galactopyranoside as substrate and fast garnet GBC as a dye coupler following polyacrylamide gel electrophoresis.	polyacrylamide	187-201	galactosidase beta 1	Homo sapiens	50-68
2512653-4	1989	We conclude that the ovine disease is due to a mutation at the genetic locus homologous with that of GM1 gangliosidosis and mucopolysaccharidosis type IVB, suggesting that the primary defect in the ovine disease is a mutation of the beta-galactosidase structural gene.	G(M1) Ganglioside	101-104	galactosidase beta 1	Homo sapiens	233-251
2481319-7	1989	A cell line that stably carries both the lacI and lacZ genes was efficiently induced to synthesize beta-galactosidase after isopropyl beta-D-thiogalactoside administration.	Isopropyl Thiogalactoside	124-156	galactosidase beta 1	Homo sapiens	99-117
2513881-0	1989	Construction of an artificial bifunctional enzyme, beta-galactosidase/galactose dehydrogenase, exhibiting efficient galactose channeling.	Galactose	70-79	galactosidase beta 1	Homo sapiens	51-69
2808357-6	1989	Structures of the oligosaccharides were estimated from the data of the binding specificities of immobilized lectin columns and the effective size of each oligosaccharide determined by passing through a Bio-Gel P-4 column and were then confirmed by endo-beta-galactosidase digestion, sequential digestion with exoglycosidases with different aglycon specificities, and methylation analysis.	Oligosaccharides	18-34	galactosidase beta 1	Homo sapiens	253-271
2550705-2	1989	EIAs using beta-galactosidase linked to P11-HS, 11 alpha-hydroxyprogesterone 11-hemimaleate (P11-HM), 11 alpha-hydroxyprogesterone 11-glucuronide (P11-Glu) or progesterone 3-(o-carboxymethyl) oxime (P3-CMO) were compared.	Hydrogen	43-46	galactosidase beta 1	Homo sapiens	11-29
2550705-2	1989	EIAs using beta-galactosidase linked to P11-HS, 11 alpha-hydroxyprogesterone 11-hemimaleate (P11-HM), 11 alpha-hydroxyprogesterone 11-glucuronide (P11-Glu) or progesterone 3-(o-carboxymethyl) oxime (P3-CMO) were compared.	11 alpha-hydroxyprogesterone 11-hemimaleate	48-91	galactosidase beta 1	Homo sapiens	11-29
2550705-2	1989	EIAs using beta-galactosidase linked to P11-HS, 11 alpha-hydroxyprogesterone 11-hemimaleate (P11-HM), 11 alpha-hydroxyprogesterone 11-glucuronide (P11-Glu) or progesterone 3-(o-carboxymethyl) oxime (P3-CMO) were compared.	p11-hm	93-99	galactosidase beta 1	Homo sapiens	11-29
2550705-2	1989	EIAs using beta-galactosidase linked to P11-HS, 11 alpha-hydroxyprogesterone 11-hemimaleate (P11-HM), 11 alpha-hydroxyprogesterone 11-glucuronide (P11-Glu) or progesterone 3-(o-carboxymethyl) oxime (P3-CMO) were compared.	11 alpha-hydroxyprogesterone 11-glucuronide	102-145	galactosidase beta 1	Homo sapiens	11-29
18588124-0	1989	Effects of temperature on the hydrolysis of lactose by immobilized beta-galactosidase in a capillary bed reactor.	Lactose	44-51	galactosidase beta 1	Homo sapiens	67-85
18588124-1	1989	The effects of temperature on the hydrolysis of lactose by immobilized beta-galactosidase were studied in a continuous flow capillary bed reactor.	Lactose	48-55	galactosidase beta 1	Homo sapiens	71-89
18588125-0	1989	Lactose hydrolysis by immobilized beta-galactosidase in capillary bed reactor.	Lactose	0-7	galactosidase beta 1	Homo sapiens	34-52
18588125-1	1989	The hydrolysis of lactose by immobilized beta-galactosidase was studied in a continuous-flow capillary bed reactor operating at 30 degrees C. Solutions containing 50, 100, and 150 g lactose and 0.5 g sodium acetate/L were fed to the reactor.	Lactose	18-25	galactosidase beta 1	Homo sapiens	41-59
18588125-1	1989	The hydrolysis of lactose by immobilized beta-galactosidase was studied in a continuous-flow capillary bed reactor operating at 30 degrees C. Solutions containing 50, 100, and 150 g lactose and 0.5 g sodium acetate/L were fed to the reactor.	Lactose	182-189	galactosidase beta 1	Homo sapiens	41-59
18588125-1	1989	The hydrolysis of lactose by immobilized beta-galactosidase was studied in a continuous-flow capillary bed reactor operating at 30 degrees C. Solutions containing 50, 100, and 150 g lactose and 0.5 g sodium acetate/L were fed to the reactor.	Sodium Acetate	200-214	galactosidase beta 1	Homo sapiens	41-59
2504311-5	1989	In addition, differences were noted in the activity of beta-galactosidase toward oligosaccharides having the Gal beta(1----3)GlcNAc or Gal beta(1----4)GlcNAc structure at reducing termini.	Oligosaccharides	81-97	galactosidase beta 1	Homo sapiens	55-73
2758123-0	1989	Elevation of urinary N-acetyl-beta-D-glucosaminidase and beta-galactosidase activities in workers with long-term exposure to aromatic nitro-amino compounds.	aromatic nitro-amino compounds	125-155	galactosidase beta 1	Homo sapiens	57-75
2498341-2	1989	The reaction was carried out over the temperature range 282-316 K and in 0.1 M sodium acetate buffer at a pH of 5.65 using the enzyme beta-galactosidase to catalyze the reaction.	Sodium Acetate	79-93	galactosidase beta 1	Homo sapiens	134-152
2499620-7	1989	SBA reactivity in UEA-I-negative cells from secretors, or in cells from fetuses and newborn infants, was markedly reduced by beta-galactosidase digestion.	sba	0-3	galactosidase beta 1	Homo sapiens	125-143
2470771-9	1989	Western blot analysis carried out on the latter samples showed that in 2 samples the apparent C2Ab reactivity was due to the presence of antibodies reacting with beta-galactosidase.	c2ab	94-98	galactosidase beta 1	Homo sapiens	162-180
2475168-2	1989	Endo-beta-galactosidase treatment resulted in the almost complete disappearance of HNK-1 staining of proteoglycan immunoblots, indicating that a significant portion of the 3-sulfated sugar residues recognized by this antibody are present on poly(N-acetyllactosaminyl) oligosaccharides.	Sugars	183-188	galactosidase beta 1	Homo sapiens	5-23
2475168-2	1989	Endo-beta-galactosidase treatment resulted in the almost complete disappearance of HNK-1 staining of proteoglycan immunoblots, indicating that a significant portion of the 3-sulfated sugar residues recognized by this antibody are present on poly(N-acetyllactosaminyl) oligosaccharides.	poly(n-acetyllactosaminyl) oligosaccharides	241-284	galactosidase beta 1	Homo sapiens	5-23
2475168-3	1989	However, after treatment with chondroitinase ABC followed by endo-beta-galactosidase, several proteoglycan species showed HNK-1 reactivity, presumably due to the presence of this epitope on other oligosaccharides which are both resistant to endo-beta-galactosidase and inaccessible to the antibody in the native proteoglycan.	Oligosaccharides	196-212	galactosidase beta 1	Homo sapiens	66-84
2475168-6	1989	However, after treatment of the proteoglycans with chondroitinase ABC (or chondroitinase and endo-beta-galactosidase) in the presence of protease inhibitors, seven bands with molecular sizes ranging from 80 to 200 kDa appear in Coomassie Blue stained gels, and two additional bands with molecular sizes of 67 and 350-400 kDa are apparent in fluorographs of sodium [35S]sulfate labeled proteoglycans.	Coomassie blue	228-242	galactosidase beta 1	Homo sapiens	98-116
2475168-6	1989	However, after treatment of the proteoglycans with chondroitinase ABC (or chondroitinase and endo-beta-galactosidase) in the presence of protease inhibitors, seven bands with molecular sizes ranging from 80 to 200 kDa appear in Coomassie Blue stained gels, and two additional bands with molecular sizes of 67 and 350-400 kDa are apparent in fluorographs of sodium [35S]sulfate labeled proteoglycans.	sodium [35s]sulfate	357-376	galactosidase beta 1	Homo sapiens	98-116
2497633-6	1989	However, the buffering capacity of the yogurt that protects bacteria from acidic gastric secretion also prevents microbial beta-galactosidase from hydrolyzing lactose in the duodenum.	Lactose	159-166	galactosidase beta 1	Homo sapiens	123-141
2504311-5	1989	In addition, differences were noted in the activity of beta-galactosidase toward oligosaccharides having the Gal beta(1----3)GlcNAc or Gal beta(1----4)GlcNAc structure at reducing termini.	gal beta(1----3)glcnac	109-131	galactosidase beta 1	Homo sapiens	55-73
2504311-5	1989	In addition, differences were noted in the activity of beta-galactosidase toward oligosaccharides having the Gal beta(1----3)GlcNAc or Gal beta(1----4)GlcNAc structure at reducing termini.	gal beta(1----4)glcnac	135-157	galactosidase beta 1	Homo sapiens	55-73
2540417-2	1989	In a cya mutant, addition of cAMP reduced the induction lag and increased the amount of beta-galactosidase produced.	Cyclic AMP	29-33	galactosidase beta 1	Homo sapiens	88-106
2538455-3	1989	We first isolated high affinity 125I-beta-galactosidase by affinity chromatography on an IGF-II/Man-6-P receptor-Sepharose column.	Sepharose	113-122	galactosidase beta 1	Homo sapiens	37-55
2538455-4	1989	Specific uptake (mannose 6-phosphate-inhibitable) of 125I-beta-galactosidase in BRL 3A2 rat liver cells and in rat C6 glial cells was 3.7-4.8 and 4.0-8.0% of added tracer, respectively.	mannose-6-phosphate	17-36	galactosidase beta 1	Homo sapiens	58-76
2538455-5	1989	The cell-associated 125I-beta-galactosidase in the uptake experiments largely represented internalized radioligand as measured by acid or mannose 6-phosphate washing.	mannose-6-phosphate	138-157	galactosidase beta 1	Homo sapiens	25-43
2499087-0	1989	[Interaction of block-polyurethane containing lactose linkages and immobilized beta-galactosidase with body tissues].	Polyurethanes	22-34	galactosidase beta 1	Homo sapiens	79-97
2538923-3	1989	This multiubiquitin chain is linked to one of two specific Lys residues in beta gal.	Lysine	59-62	galactosidase beta 1	Homo sapiens	75-83
2538923-4	1989	These same Lys residues have been identified by molecular genetic analysis as components of the aminoterminal degradation signal in beta gal.	Lysine	11-14	galactosidase beta 1	Homo sapiens	132-140
2496942-1	1989	In order to delineate clinical subtypes of GM1 gangliosidosis enzymologically, we prepared galactosyl oligosaccharides from the urine of patients, as substrates, and established the method of the galactosyl oligosaccharide beta-galactosidase assay.	galactosyl oligosaccharides	91-118	galactosidase beta 1	Homo sapiens	223-241
2496942-1	1989	In order to delineate clinical subtypes of GM1 gangliosidosis enzymologically, we prepared galactosyl oligosaccharides from the urine of patients, as substrates, and established the method of the galactosyl oligosaccharide beta-galactosidase assay.	galactosyl oligosaccharide	91-117	galactosidase beta 1	Homo sapiens	223-241
2496942-2	1989	Galactosyl oligosaccharides beta-galactosidase activities (nmol/mg protein/20 h) in vitro, using substrates without repeating structures were; type 1, 1.0 +/- 0.5 (n = 6), type 2A, 2.1, type 2B, 3.4 +/- 0.7 (n = 5), type 3, 4.9 +/- 0.2 (n = 2).	galactosyl oligosaccharides	0-27	galactosidase beta 1	Homo sapiens	28-46
2910868-5	1989	A considerable portion of neutral alditols is represented by branched isomers of the linear species, which are distinguished by their content of 3,6-disubstituted galactose and their partial resistance to endo-beta-galactosidase digestion.	Sugar Alcohols	34-42	galactosidase beta 1	Homo sapiens	210-228
2492258-4	1989	A third, sialic acid-specific adhesion activity was suggested for two additional strains on the basis of their agglutination of native and endo-beta-galactosidase-treated but not sialidase-treated erythrocytes.	N-Acetylneuraminic Acid	9-20	galactosidase beta 1	Homo sapiens	144-162
3170547-4	1988	Studies on glycopeptides modified by desialylation, desulfation, and beta-galactosidase treatment indicated that the majority (approximately 70%) of the complex carbohydrate units contain sulfate groups and that Gal-3-SO4 and sialic acid residues can coexist in terminal positions on the same N-linked oligosaccharide.	Glycopeptides	11-24	galactosidase beta 1	Homo sapiens	69-87
3141588-1	1988	Poly(N-acetyllactosaminyl) oligosaccharides have been identified, on the basis of their susceptibility to endo-beta-galactosidase, in a large-molecular-size glycopeptide fraction derived from chromaffin granule membrane glycoproteins.	poly(n-acetyllactosaminyl) oligosaccharides	0-43	galactosidase beta 1	Homo sapiens	111-129
3141588-2	1988	The glycoproteins containing poly(N-acetyl-lactosaminyl) oligosaccharides were selectively labeled by treatment of chromaffin granule membranes with endo-beta-galactosidase to expose N-acetylglucosamine residues, followed by incubation with galactosyltransferase and UDP-[14C]galactose.	poly(n-acetyl-lactosaminyl) oligosaccharides	29-73	galactosidase beta 1	Homo sapiens	154-172
3141588-2	1988	The glycoproteins containing poly(N-acetyl-lactosaminyl) oligosaccharides were selectively labeled by treatment of chromaffin granule membranes with endo-beta-galactosidase to expose N-acetylglucosamine residues, followed by incubation with galactosyltransferase and UDP-[14C]galactose.	Acetylglucosamine	183-202	galactosidase beta 1	Homo sapiens	154-172
2492796-1	1989	The beta-galactosidase (EC 3.2.1.32) of Corynebacterium murisepticum (inducible by lactose and galactose) was purified by successive column chromatography on Sephadex G-200, DEAE-Sephadex A-50 and DEAE-cellulose (DE52).	Lactose	83-90	galactosidase beta 1	Homo sapiens	4-22
2492796-1	1989	The beta-galactosidase (EC 3.2.1.32) of Corynebacterium murisepticum (inducible by lactose and galactose) was purified by successive column chromatography on Sephadex G-200, DEAE-Sephadex A-50 and DEAE-cellulose (DE52).	Galactose	95-104	galactosidase beta 1	Homo sapiens	4-22
2492796-1	1989	The beta-galactosidase (EC 3.2.1.32) of Corynebacterium murisepticum (inducible by lactose and galactose) was purified by successive column chromatography on Sephadex G-200, DEAE-Sephadex A-50 and DEAE-cellulose (DE52).	sephadex	158-172	galactosidase beta 1	Homo sapiens	4-22
2492796-1	1989	The beta-galactosidase (EC 3.2.1.32) of Corynebacterium murisepticum (inducible by lactose and galactose) was purified by successive column chromatography on Sephadex G-200, DEAE-Sephadex A-50 and DEAE-cellulose (DE52).	DEAE-Sephadex A-50	174-192	galactosidase beta 1	Homo sapiens	4-22
2492796-1	1989	The beta-galactosidase (EC 3.2.1.32) of Corynebacterium murisepticum (inducible by lactose and galactose) was purified by successive column chromatography on Sephadex G-200, DEAE-Sephadex A-50 and DEAE-cellulose (DE52).	DEAE-Cellulose	197-211	galactosidase beta 1	Homo sapiens	4-22
3063259-7	1988	Digestion of the [125I]IAPS-forskolin-labelled placental and WT lymphoma membranes with endo-beta-galactosidase showed a reduction in the apparent molecular mass of the radiolabelled band to approx.	Colforsin	28-37	galactosidase beta 1	Homo sapiens	93-111
3170547-4	1988	Studies on glycopeptides modified by desialylation, desulfation, and beta-galactosidase treatment indicated that the majority (approximately 70%) of the complex carbohydrate units contain sulfate groups and that Gal-3-SO4 and sialic acid residues can coexist in terminal positions on the same N-linked oligosaccharide.	Carbohydrates	161-173	galactosidase beta 1	Homo sapiens	69-87
3170988-3	1988	Beta-galactosidase-conjugated streptavidin was used for detection of the captured allergen, 4-methylumbelliferyl-beta-D-galactoside was used as the enzyme substrate, and fluorescence intensity of the product, 4-methylumbelliferone, was measured by a fluorometric reader.	4-methylumbelliferyl-galactopyranoside	92-131	galactosidase beta 1	Homo sapiens	0-18
3147126-2	1988	Two forms, I and II, of beta-galactosidase [EC 3.2.1.23] from fowl spermatozoa were separated by Blue-Sepharose CL-6B chromatography.	sepharose CL 6B	102-117	galactosidase beta 1	Homo sapiens	24-42
3170988-3	1988	Beta-galactosidase-conjugated streptavidin was used for detection of the captured allergen, 4-methylumbelliferyl-beta-D-galactoside was used as the enzyme substrate, and fluorescence intensity of the product, 4-methylumbelliferone, was measured by a fluorometric reader.	Hymecromone	209-230	galactosidase beta 1	Homo sapiens	0-18
3218125-1	1988	Correlation between activity of beta-galactosidase, N-acetyl-beta-D-glucosaminidase and content of cAMP and cGMP was studied in lymphocytes and polymorphonuclear leukocytes obtained from 20 children with atopic form of bronchial asthma and 9 patients with dermorespiratory syndrome.	Cyclic AMP	99-103	galactosidase beta 1	Homo sapiens	32-50
3142291-1	1988	Two novel affinity tails, polycysteine and polyphenylalanine, have been genetically attached to galactokinase (EC 2.7.1.6) and beta-galactosidase (EC 3.2.1.23) in order to facilitate their purification.	polycysteine	26-38	galactosidase beta 1	Homo sapiens	127-145
3142291-1	1988	Two novel affinity tails, polycysteine and polyphenylalanine, have been genetically attached to galactokinase (EC 2.7.1.6) and beta-galactosidase (EC 3.2.1.23) in order to facilitate their purification.	polyphenylalanine	43-60	galactosidase beta 1	Homo sapiens	127-145
3142291-7	1988	One of the obtained genetic transformants coding for a beta-galactosidase carrying 11 phenylalanine residues at the N-terminus of the enzyme was isolated.	Phenylalanine	86-99	galactosidase beta 1	Homo sapiens	55-73
2967821-6	1988	Affinity cross-linking of 125I-IGF-II to the Man-6-P receptor and analysis by sodium dodecyl sulfate-gel electrophoresis showed that beta-galactosidase, but not Man-6-P, inhibited the formation of the 250-kDa 125I-IGF-II-receptor complex.	Sodium Dodecyl Sulfate	78-100	galactosidase beta 1	Homo sapiens	133-151
3146253-4	1988	6-HMGal analogues with shorter acyl residues, octanoyl (OMGal) and butanoyl (BMGal), were cleaved by another type of beta-galactosidase, GM1-ganglioside-beta-galactosidase.	octanoyl	46-54	galactosidase beta 1	Homo sapiens	117-135
3146253-4	1988	6-HMGal analogues with shorter acyl residues, octanoyl (OMGal) and butanoyl (BMGal), were cleaved by another type of beta-galactosidase, GM1-ganglioside-beta-galactosidase.	octanoyl	46-54	galactosidase beta 1	Homo sapiens	153-171
3146253-4	1988	6-HMGal analogues with shorter acyl residues, octanoyl (OMGal) and butanoyl (BMGal), were cleaved by another type of beta-galactosidase, GM1-ganglioside-beta-galactosidase.	butanoyl	67-75	galactosidase beta 1	Homo sapiens	117-135
3146253-4	1988	6-HMGal analogues with shorter acyl residues, octanoyl (OMGal) and butanoyl (BMGal), were cleaved by another type of beta-galactosidase, GM1-ganglioside-beta-galactosidase.	butanoyl	67-75	galactosidase beta 1	Homo sapiens	153-171
3146253-4	1988	6-HMGal analogues with shorter acyl residues, octanoyl (OMGal) and butanoyl (BMGal), were cleaved by another type of beta-galactosidase, GM1-ganglioside-beta-galactosidase.	G(M1) Ganglioside	137-152	galactosidase beta 1	Homo sapiens	117-135
3146253-4	1988	6-HMGal analogues with shorter acyl residues, octanoyl (OMGal) and butanoyl (BMGal), were cleaved by another type of beta-galactosidase, GM1-ganglioside-beta-galactosidase.	G(M1) Ganglioside	137-152	galactosidase beta 1	Homo sapiens	153-171
2837176-4	1988	Fractions from a modified sucrose equilibrium gradient exhibited beta-galactosidase activity in fractions corresponding to outer membrane-heavy (OMH) and outer membrane light (OML).	Sucrose	26-33	galactosidase beta 1	Homo sapiens	65-83
3379051-15	1988	About 30% of the 35S-labeled oligosaccharides from CPAE were sensitive to endo-beta-galactosidase, indicating that poly-N-acetyl-lactosamine structures were present on some chains.	Sulfur-35	17-20	galactosidase beta 1	Homo sapiens	79-97
3379051-15	1988	About 30% of the 35S-labeled oligosaccharides from CPAE were sensitive to endo-beta-galactosidase, indicating that poly-N-acetyl-lactosamine structures were present on some chains.	Oligosaccharides	29-45	galactosidase beta 1	Homo sapiens	79-97
3379051-15	1988	About 30% of the 35S-labeled oligosaccharides from CPAE were sensitive to endo-beta-galactosidase, indicating that poly-N-acetyl-lactosamine structures were present on some chains.	cpae	51-55	galactosidase beta 1	Homo sapiens	79-97
3379051-15	1988	About 30% of the 35S-labeled oligosaccharides from CPAE were sensitive to endo-beta-galactosidase, indicating that poly-N-acetyl-lactosamine structures were present on some chains.	poly-N-acetyllactosamine	115-140	galactosidase beta 1	Homo sapiens	79-97
3132345-5	1988	Only for men was a positive relation between the level of mercury in urine and the activity of beta-galactosidase found.	Mercury	58-65	galactosidase beta 1	Homo sapiens	95-113
3129960-5	1988	Then, the beta-galactosidase specifically bound to the antibody was assayed fluorometrically, and the enzyme activity was correlated with the amount of unlabeled prostaglandin E2.	Dinoprostone	162-178	galactosidase beta 1	Homo sapiens	10-28
3360793-5	1988	The oligosaccharide of GM1 and deacetyl-fatty acid free GM1 (II3-NeuGg-Ose4-sphingosine) were hydrolyzed by beta-galactosidase in the absence of this activator protein.	Oligosaccharides	4-19	galactosidase beta 1	Homo sapiens	108-126
3360793-5	1988	The oligosaccharide of GM1 and deacetyl-fatty acid free GM1 (II3-NeuGg-Ose4-sphingosine) were hydrolyzed by beta-galactosidase in the absence of this activator protein.	G(M1) Ganglioside	23-26	galactosidase beta 1	Homo sapiens	108-126
3360793-5	1988	The oligosaccharide of GM1 and deacetyl-fatty acid free GM1 (II3-NeuGg-Ose4-sphingosine) were hydrolyzed by beta-galactosidase in the absence of this activator protein.	deacetyl-fatty acid	31-50	galactosidase beta 1	Homo sapiens	108-126
3360793-5	1988	The oligosaccharide of GM1 and deacetyl-fatty acid free GM1 (II3-NeuGg-Ose4-sphingosine) were hydrolyzed by beta-galactosidase in the absence of this activator protein.	G(M1) Ganglioside	56-59	galactosidase beta 1	Homo sapiens	108-126
3360793-5	1988	The oligosaccharide of GM1 and deacetyl-fatty acid free GM1 (II3-NeuGg-Ose4-sphingosine) were hydrolyzed by beta-galactosidase in the absence of this activator protein.	ii3-neugg-ose4-sphingosine	61-87	galactosidase beta 1	Homo sapiens	108-126
3133384-0	1988	Microassay for GM1 ganglioside beta-galactosidase activity using high-performance liquid chromatography.	G(M1) Ganglioside	15-18	galactosidase beta 1	Homo sapiens	31-49
3133384-1	1988	A simple and sensitive assay for GM1 ganglioside (GM1) beta-galactosidase activity was devised by direct measurement of released D-galactose using high-performance liquid chromatography (HPLC).	G(M1) Ganglioside	33-48	galactosidase beta 1	Homo sapiens	55-73
3133384-1	1988	A simple and sensitive assay for GM1 ganglioside (GM1) beta-galactosidase activity was devised by direct measurement of released D-galactose using high-performance liquid chromatography (HPLC).	G(M1) Ganglioside	33-36	galactosidase beta 1	Homo sapiens	55-73
3133384-1	1988	A simple and sensitive assay for GM1 ganglioside (GM1) beta-galactosidase activity was devised by direct measurement of released D-galactose using high-performance liquid chromatography (HPLC).	Galactose	129-140	galactosidase beta 1	Homo sapiens	55-73
2897256-3	1988	The biotinylated enzymatic product is immobilized onto 96-well microtiter plates, complexed with streptavidin-beta-galactosidase, and the absorbance at 405 nm is monitored for production of p-nitrophenol from p-nitrophenyl-beta-D-galactopyranoside.	4-nitrophenol	190-203	galactosidase beta 1	Homo sapiens	110-128
3128327-0	1988	beta-Galactosidase-induced destabilization of liposome composed of phosphatidylethanolamine and ganglioside GM1.	phosphatidylethanolamine	67-91	galactosidase beta 1	Homo sapiens	0-18
3128327-0	1988	beta-Galactosidase-induced destabilization of liposome composed of phosphatidylethanolamine and ganglioside GM1.	Gangliosides	96-107	galactosidase beta 1	Homo sapiens	0-18
3128327-0	1988	beta-Galactosidase-induced destabilization of liposome composed of phosphatidylethanolamine and ganglioside GM1.	G(M1) Ganglioside	108-111	galactosidase beta 1	Homo sapiens	0-18
3128327-4	1988	Treatment of these GM1/PE liposomes with beta-galactosidase induces a rapid leakage (3-6 min) of the entrapped fluorescent dye, calcein.	G(M1) Ganglioside	19-22	galactosidase beta 1	Homo sapiens	41-59
3128279-1	1988	of oligosaccharides of N-acetyl-lactosamine-type released from human erythrocyte glycopeptides by endo-beta-galactosidase.	Oligosaccharides	3-19	galactosidase beta 1	Homo sapiens	103-121
3128279-1	1988	of oligosaccharides of N-acetyl-lactosamine-type released from human erythrocyte glycopeptides by endo-beta-galactosidase.	N-acetyllactosamine	23-43	galactosidase beta 1	Homo sapiens	103-121
3128279-1	1988	of oligosaccharides of N-acetyl-lactosamine-type released from human erythrocyte glycopeptides by endo-beta-galactosidase.	Glycopeptides	81-94	galactosidase beta 1	Homo sapiens	103-121
3128279-3	1988	spectroscopy has been used in structural studies of three linear and five branched oligosaccharides of N-acetyl-lactosamine-type that were released from desialylated blood group O erythrocyte glycopeptides by treatment with the endo-beta-galactosidase of Bacteroides fragilis followed by reduction.	Oligosaccharides	83-99	galactosidase beta 1	Homo sapiens	233-251
3128279-3	1988	spectroscopy has been used in structural studies of three linear and five branched oligosaccharides of N-acetyl-lactosamine-type that were released from desialylated blood group O erythrocyte glycopeptides by treatment with the endo-beta-galactosidase of Bacteroides fragilis followed by reduction.	N-acetyllactosamine	103-123	galactosidase beta 1	Homo sapiens	233-251
3693367-7	1987	Endo-beta-galactosidase digestion of [125I] IAPS-forskolin-labeled ghosts and purified transporter resulted in a dramatic sharpening of the specifically radiolabeled transporter to 40 kDa.	Colforsin	49-58	galactosidase beta 1	Homo sapiens	5-23
3147610-0	1988	Lactose hydrolysis and oligosaccharide formation catalyzed by beta-galactosidase.	Lactose	0-7	galactosidase beta 1	Homo sapiens	62-80
3147610-0	1988	Lactose hydrolysis and oligosaccharide formation catalyzed by beta-galactosidase.	Oligosaccharides	23-38	galactosidase beta 1	Homo sapiens	62-80
3389687-3	1988	Kinetic curves of excretion for adriamycin, bleomycin, dacarbazine, cis-platinum and vincristine and their mixtures have been constructed from standard curves relating the intensity of the beta-galactosidase response to the concentration of drugs dissolved in normal urine.	Vincristine	85-96	galactosidase beta 1	Homo sapiens	189-207
3145222-0	1988	[Effect of penicillin and D-penicillamine on beta-galactosidase activity in patients with progressive scleroderma].	Penicillins	11-21	galactosidase beta 1	Homo sapiens	45-63
3145222-0	1988	[Effect of penicillin and D-penicillamine on beta-galactosidase activity in patients with progressive scleroderma].	Penicillamine	26-41	galactosidase beta 1	Homo sapiens	45-63
18581545-1	1987	Enzymatic lactose hydrolysis by beta-galactosidase (lactase) was investigated with respect to the formation of oligosaccharides.	Lactose	10-17	galactosidase beta 1	Homo sapiens	32-50
18581545-1	1987	Enzymatic lactose hydrolysis by beta-galactosidase (lactase) was investigated with respect to the formation of oligosaccharides.	Oligosaccharides	111-127	galactosidase beta 1	Homo sapiens	32-50
3692478-1	1987	Galactosyl ceramide beta-galactosidase activity was determined in chorionic villi (CV) samples obtained between the 9th and 11th weeks of gestation from 5 women with pregnancies at risk for Krabbe"s disease (globoid-cell leukodystrophy, KD).	Galactosylceramides	0-19	galactosidase beta 1	Homo sapiens	20-38
3116836-7	1987	Peak hydrogen excretion after consumption of frozen yogurt with high beta-gal was less than one-half of that observed after the other five test meals and intolerance symptoms were absent.	Hydrogen	5-13	galactosidase beta 1	Homo sapiens	69-77
3121219-3	1987	Study of the residual fibroblast beta-galactosidase activity towards 4-methylumbelliferyl and p-nitrophenyl beta-D-galactosides indicated that the mutation resembles that in typical Morquio B disease (increased Km and similar pH maximum) rather than that in GM1-gangliosidosis.	4-nitrophenylgalactoside	94-127	galactosidase beta 1	Homo sapiens	33-51
3122722-6	1987	The glycopeptides which were specifically bound to the lectin column were largely degraded by endo-beta-galactosidase, thereby indicating that they consisted of fucosylated polylactosaminoglycans.	lactosaminoglycan	173-195	galactosidase beta 1	Homo sapiens	99-117
3122598-2	1987	The optimum conditions of beta-galactosidase in the 80% ammonium sulfate precipitates of the culture medium of Streptococcus (Diplococcus) pneumoniae were determined with nLcOse4Cer radiolabeled by the galactose oxidase-NaB3H4 procedure.	Ammonium Sulfate	56-72	galactosidase beta 1	Homo sapiens	26-44
2823641-3	1987	The lysosomal enzyme ligand, testicular beta-galactosidase, was added and receptor-bound beta-galactosidase was measured by conventional colorimetric analysis using p-nitrophenyl beta-galactoside as substrate.	p-nitrophenyl beta-galactoside	165-195	galactosidase beta 1	Homo sapiens	89-107
2823641-6	1987	Binding of beta-galactosidase to the receptor was specifically inhibited by 5 mM mannose 6-phosphate.	mannose-6-phosphate	81-100	galactosidase beta 1	Homo sapiens	11-29
2823641-7	1987	The receptor exhibited optimum binding of beta-galactosidase at pH 5.7 and was saturated with beta-galactosidase at 320 munits/ml in the presence of 20 mM MnCl2.	manganese chloride	155-160	galactosidase beta 1	Homo sapiens	42-60
2823641-7	1987	The receptor exhibited optimum binding of beta-galactosidase at pH 5.7 and was saturated with beta-galactosidase at 320 munits/ml in the presence of 20 mM MnCl2.	manganese chloride	155-160	galactosidase beta 1	Homo sapiens	94-112
2823641-8	1987	The requirement for MnCl2 was greatly diminished at higher concentrations of beta-galactosidase.	manganese chloride	20-25	galactosidase beta 1	Homo sapiens	77-95
2959666-10	1987	Biochemical analysis of the internalized ligands indicates that: (a) the subunit molecular mass of both beta-glucuronidase and beta-galactosidase decrease upon cell association relative to the input form of the enzymes, and (b) the beta-glucuronidase molecules experience a limited dephosphorylation such that high-mannose-type oligosaccharides containing two phosphomonoesters are converted to single phosphomonoester forms.	Mannose	315-322	galactosidase beta 1	Homo sapiens	127-145
2959666-10	1987	Biochemical analysis of the internalized ligands indicates that: (a) the subunit molecular mass of both beta-glucuronidase and beta-galactosidase decrease upon cell association relative to the input form of the enzymes, and (b) the beta-glucuronidase molecules experience a limited dephosphorylation such that high-mannose-type oligosaccharides containing two phosphomonoesters are converted to single phosphomonoester forms.	Oligosaccharides	328-344	galactosidase beta 1	Homo sapiens	127-145
3122598-2	1987	The optimum conditions of beta-galactosidase in the 80% ammonium sulfate precipitates of the culture medium of Streptococcus (Diplococcus) pneumoniae were determined with nLcOse4Cer radiolabeled by the galactose oxidase-NaB3H4 procedure.	nlcose4cer	171-181	galactosidase beta 1	Homo sapiens	26-44
3122598-2	1987	The optimum conditions of beta-galactosidase in the 80% ammonium sulfate precipitates of the culture medium of Streptococcus (Diplococcus) pneumoniae were determined with nLcOse4Cer radiolabeled by the galactose oxidase-NaB3H4 procedure.	nab3h4	220-226	galactosidase beta 1	Homo sapiens	26-44
3123472-5	1987	beta-Galactosidase-treated embryoglycan (poly-N-acetyllactosamine) and asialo-agalactofetuin could serve as acceptors with the purified enzyme.	poly-N-acetyllactosamine	41-65	galactosidase beta 1	Homo sapiens	0-18
3429451-4	1987	The presence of oligo-N-acetyllactosamine units in the N-linked type sugars was indicated by endo-beta-galactosidase digestion.	oligo-n-acetyllactosamine	16-41	galactosidase beta 1	Homo sapiens	98-116
3429451-4	1987	The presence of oligo-N-acetyllactosamine units in the N-linked type sugars was indicated by endo-beta-galactosidase digestion.	Sugars	69-75	galactosidase beta 1	Homo sapiens	98-116
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	p-aminophenyl alpha- or beta-glycosides	42-81	galactosidase beta 1	Homo sapiens	7-15
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	p-aminophenyl alpha- or beta-glycosides	42-81	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	p-aminophenyl alpha- or beta-glycosides	42-81	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	p-aminophenyl alpha- or beta-glycosides	42-81	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	4-Aminophenyl beta-D-glucopyranoside	106-142	galactosidase beta 1	Homo sapiens	7-15
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	4-Aminophenyl beta-D-glucopyranoside	106-142	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	4-Aminophenyl beta-D-glucopyranoside	106-142	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	4-Aminophenyl beta-D-glucopyranoside	106-142	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	beta-D-galactose	241-259	galactosidase beta 1	Homo sapiens	7-15
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	beta-D-galactose	241-259	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	beta-D-galactose	241-259	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	beta-D-galactose	241-259	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	alpha-D-Mannose	269-286	galactosidase beta 1	Homo sapiens	7-15
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	alpha-D-Mannose	269-286	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	alpha-D-Mannose	269-286	galactosidase beta 1	Homo sapiens	83-91
3116472-2	1987	Out of beta-gal modified with a series of p-aminophenyl alpha- or beta-glycosides, beta-gal modified with p-aminophenyl beta-D-glucopyranoside (beta-D-Glc beta-gal) was bound to the synaptosomes most effectively, then beta-gal modified with beta-D-galactoside and with alpha-D-mannoside.	alpha-D-Mannose	269-286	galactosidase beta 1	Homo sapiens	83-91
3116472-3	1987	Kinetic studies on the binding of beta-D-Glc beta-gal indicated the presence of saturable binding on human brain synaptosomes.	Zymosan	34-44	galactosidase beta 1	Homo sapiens	45-53
3116472-5	1987	The specificity of the sugar recognition site proved by the competitive inhibition of the binding of beta-D-Glc beta-gal by bovine serum albumin modified with the same glycoside.	Sugars	23-28	galactosidase beta 1	Homo sapiens	112-120
3116472-5	1987	The specificity of the sugar recognition site proved by the competitive inhibition of the binding of beta-D-Glc beta-gal by bovine serum albumin modified with the same glycoside.	Glycosides	168-177	galactosidase beta 1	Homo sapiens	112-120
3116472-6	1987	The binding of beta-gal modified with beta-D-galactoside was inhibited by treatment of the synaptosomes with trypsin, phospholipase A2, C and D, and with neuraminidase, while the binding of beta-D-Glc beta-gal was inhibited by neuraminidase treatment of synaptosomes.	beta-D-galactose	38-56	galactosidase beta 1	Homo sapiens	15-23
3116472-6	1987	The binding of beta-gal modified with beta-D-galactoside was inhibited by treatment of the synaptosomes with trypsin, phospholipase A2, C and D, and with neuraminidase, while the binding of beta-D-Glc beta-gal was inhibited by neuraminidase treatment of synaptosomes.	beta-D-galactose	38-56	galactosidase beta 1	Homo sapiens	201-209
3111543-4	1987	Lactosylsphingosine beta-galactosidase activities assayed in the absence and the presence of taurocholate (probably lactosylceramidase I) were deficient in fibroblasts from patients with globoid cell leukodystrophy, while the activity assayed with sodium cholate (probably lactosylceramidase II) was deficient in GM1 gangliosidosis fibroblasts.	Sodium Cholate	248-262	galactosidase beta 1	Homo sapiens	20-38
3111543-4	1987	Lactosylsphingosine beta-galactosidase activities assayed in the absence and the presence of taurocholate (probably lactosylceramidase I) were deficient in fibroblasts from patients with globoid cell leukodystrophy, while the activity assayed with sodium cholate (probably lactosylceramidase II) was deficient in GM1 gangliosidosis fibroblasts.	G(M1) Ganglioside	313-316	galactosidase beta 1	Homo sapiens	20-38
3609611-2	1987	The oligosaccharide chains of this enzyme were enzymatically removed with various glycosidic enzymes (endoglycosidases D, F, and H; glycopeptidase F; alpha-mannosidase; neuraminidase; and beta-galactosidase).	Oligosaccharides	4-19	galactosidase beta 1	Homo sapiens	188-206
3117549-0	1987	Characterisation of oligosaccharides released from human-blood-group O erythrocyte glycopeptides by the endo-beta-galactosidase of Bacteroides fragilis.	Oligosaccharides	20-36	galactosidase beta 1	Homo sapiens	109-127
3117549-8	1987	259, 6586-6592], the endo-beta-galactosidase of Bacteroides fragilis cannot hydrolyse branch-point beta-galactosidic linkages on erythrocyte membrane glycopeptides.	Glycopeptides	150-163	galactosidase beta 1	Homo sapiens	26-44
3615358-1	1987	Chorionic villi obtained during the first trimester from a pregnancy at risk for Krabbe"s disease were shown to have reduced cerebroside-beta-galactosidase (E.C.3.2.1.46) activity using the artificial substrate trinitrophenylaminolauryl galactocerebroside (TNPAL-galactocerebroside).	trinitrophenylaminolauryl galactocerebroside	211-255	galactosidase beta 1	Homo sapiens	137-155
3106349-9	1987	Treatment of membranes labeled with either cytochalasin B or forskolin with endo-beta-galactosidase resulted in identical shifts of the 43 to 75-kDa peaks to 42 kDa.	Cytochalasin B	43-57	galactosidase beta 1	Homo sapiens	81-99
3106349-9	1987	Treatment of membranes labeled with either cytochalasin B or forskolin with endo-beta-galactosidase resulted in identical shifts of the 43 to 75-kDa peaks to 42 kDa.	Colforsin	61-70	galactosidase beta 1	Homo sapiens	81-99
3117033-3	1987	The enzyme is active against a wide range of aryl beta-glycosides and beta-linked disaccharides, with beta-galactosidase activity only slightly less than beta-glucosidase activity, and significant beta-xylosidase activity.	aryl beta-glycosides	45-65	galactosidase beta 1	Homo sapiens	102-120
3035998-0	1987	Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.	G(M1) Ganglioside	16-31	galactosidase beta 1	Homo sapiens	32-50
3035998-0	1987	Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.	Gangliosides	20-31	galactosidase beta 1	Homo sapiens	32-50
3035998-2	1987	Utilizing a specific inactivator of the lysosomal enzyme GM1-ganglioside beta-galactosidase (beta-D-galactopyranosylmethyl-p-nitrophenyltriazene [beta-GalMNT]) and neuroblastoma X glioma hybrid cells (NG108-15), we suppressed beta-galactosidase activity for up to 72 hours.	G(M1) Ganglioside	57-72	galactosidase beta 1	Homo sapiens	73-91
3035998-2	1987	Utilizing a specific inactivator of the lysosomal enzyme GM1-ganglioside beta-galactosidase (beta-D-galactopyranosylmethyl-p-nitrophenyltriazene [beta-GalMNT]) and neuroblastoma X glioma hybrid cells (NG108-15), we suppressed beta-galactosidase activity for up to 72 hours.	G(M1) Ganglioside	57-72	galactosidase beta 1	Homo sapiens	226-244
3035998-2	1987	Utilizing a specific inactivator of the lysosomal enzyme GM1-ganglioside beta-galactosidase (beta-D-galactopyranosylmethyl-p-nitrophenyltriazene [beta-GalMNT]) and neuroblastoma X glioma hybrid cells (NG108-15), we suppressed beta-galactosidase activity for up to 72 hours.	beta-D-galactopyranosylmethyl-4-nitrophenyltriazene	146-157	galactosidase beta 1	Homo sapiens	73-91
3117033-3	1987	The enzyme is active against a wide range of aryl beta-glycosides and beta-linked disaccharides, with beta-galactosidase activity only slightly less than beta-glucosidase activity, and significant beta-xylosidase activity.	beta-linked disaccharides	70-95	galactosidase beta 1	Homo sapiens	102-120
3104037-7	1987	By using a third enzyme, galactose dehydrogenase, which competes with galactokinase for the galactose formed by beta-galactosidase, substrate channeling can be detected.	Galactose	25-34	galactosidase beta 1	Homo sapiens	112-130
3298291-6	1987	Components c and d were also cleaved slowly, resulting in the production of monodansyl hydroxylysine by the successive action of beta-galactosidase on dansyl galactosyl hydroxylysine.	monodansyl hydroxylysine	76-100	galactosidase beta 1	Homo sapiens	129-147
3103693-6	1987	It was thus suggested that the endo-types of beta-xylosidase, beta-galactosidase and beta-glucuronidase acted on the carbohydrate-peptide linkage region of proteo-chondroitin sulfate in the tissues and produced various types of urinary chondroitin sulfate with heterogeneity at reducing terminals.	Carbohydrates	117-129	galactosidase beta 1	Homo sapiens	62-80
3103693-6	1987	It was thus suggested that the endo-types of beta-xylosidase, beta-galactosidase and beta-glucuronidase acted on the carbohydrate-peptide linkage region of proteo-chondroitin sulfate in the tissues and produced various types of urinary chondroitin sulfate with heterogeneity at reducing terminals.	Chondroitin Sulfates	163-182	galactosidase beta 1	Homo sapiens	62-80
3103693-6	1987	It was thus suggested that the endo-types of beta-xylosidase, beta-galactosidase and beta-glucuronidase acted on the carbohydrate-peptide linkage region of proteo-chondroitin sulfate in the tissues and produced various types of urinary chondroitin sulfate with heterogeneity at reducing terminals.	Chondroitin Sulfates	236-255	galactosidase beta 1	Homo sapiens	62-80
3107972-6	1987	Valproic acid was the only medication to act as a differentiating agent, significantly increasing the activity of choline acetyltransferase, beta-galactosidase, and muscarinic cholinergic receptor binding.	Valproic Acid	0-13	galactosidase beta 1	Homo sapiens	141-196
3109465-0	1987	Strong inhibitory effect of furanoses and sugar lactones on beta-galactosidase Escherichia coli.	furanoses	28-37	galactosidase beta 1	Homo sapiens	60-78
3109465-0	1987	Strong inhibitory effect of furanoses and sugar lactones on beta-galactosidase Escherichia coli.	sugar lactones	42-56	galactosidase beta 1	Homo sapiens	60-78
3109465-1	1987	Various sugars and their lactones were tested for their inhibition of beta-galactosidase (Escherichia coli).	Sugars	8-14	galactosidase beta 1	Homo sapiens	70-88
3109465-1	1987	Various sugars and their lactones were tested for their inhibition of beta-galactosidase (Escherichia coli).	Lactones	25-33	galactosidase beta 1	Homo sapiens	70-88
3109465-5	1987	This is the first report of the inhibitory effect of furanose on beta-galactosidase.	furanose	53-61	galactosidase beta 1	Homo sapiens	65-83
3109465-10	1987	Inhibition of beta-galactosidases from mammalian sources by lactones has been reported previously, but this is the first report of the effect of beta-galactosidase from E. coli.	Lactones	60-68	galactosidase beta 1	Homo sapiens	14-32
3109465-11	1987	Since furanoses in the envelope form are analogous (in some ways) to half-chair or sofa conformations and since lactones with six-membered rings probably have half-chair or sofa conformations, the results indicate that beta-galactosidase probably destabilizes its substrate into a planar conformation of some type and that the galactose in the transition state may, therefore, also be quite planar.	furanoses	6-15	galactosidase beta 1	Homo sapiens	219-237
3109465-11	1987	Since furanoses in the envelope form are analogous (in some ways) to half-chair or sofa conformations and since lactones with six-membered rings probably have half-chair or sofa conformations, the results indicate that beta-galactosidase probably destabilizes its substrate into a planar conformation of some type and that the galactose in the transition state may, therefore, also be quite planar.	Lactones	112-120	galactosidase beta 1	Homo sapiens	219-237
3109465-11	1987	Since furanoses in the envelope form are analogous (in some ways) to half-chair or sofa conformations and since lactones with six-membered rings probably have half-chair or sofa conformations, the results indicate that beta-galactosidase probably destabilizes its substrate into a planar conformation of some type and that the galactose in the transition state may, therefore, also be quite planar.	Galactose	327-336	galactosidase beta 1	Homo sapiens	219-237
2965059-10	1987	This protein was recognized by antibody to the human acid phosphatase isoenzyme 2a/4 and anti-beta-galactosidase and was produced only upon induction with IPTG.	Isopropyl Thiogalactoside	155-159	galactosidase beta 1	Homo sapiens	94-112
3106281-8	1987	Three species of antigenic gangliosides in pooled meconium were tentatively identified as GM3(NeuGc), sialylparagloboside and sialylhexaosylceramide on the basis of their migration positions on 2d-TLC and the results of endo-beta-galactosidase treatment.	Gangliosides	27-39	galactosidase beta 1	Homo sapiens	225-243
3553256-10	1987	Improved lactose digestion appears due to autodigestion by microbial beta-galactosidase.	Lactose	9-16	galactosidase beta 1	Homo sapiens	69-87
3118327-0	1987	Efficacy testing of beta-galactosidase with H2 breath test in patients with carbohydrate malabsorption.	Carbohydrates	76-88	galactosidase beta 1	Homo sapiens	20-38
3118327-4	1987	It was established that pretreatment of milk with beta-galactosidase has a beneficial effect in adult lactose maldigestion, since it stops dyspeptic complaints and diarrhoea due to milk, it reduces the H2 content of expired air increases blood glucose concentration.	Lactose	102-109	galactosidase beta 1	Homo sapiens	50-68
3118327-4	1987	It was established that pretreatment of milk with beta-galactosidase has a beneficial effect in adult lactose maldigestion, since it stops dyspeptic complaints and diarrhoea due to milk, it reduces the H2 content of expired air increases blood glucose concentration.	Hydrogen	202-204	galactosidase beta 1	Homo sapiens	50-68
3118327-4	1987	It was established that pretreatment of milk with beta-galactosidase has a beneficial effect in adult lactose maldigestion, since it stops dyspeptic complaints and diarrhoea due to milk, it reduces the H2 content of expired air increases blood glucose concentration.	Glucose	244-251	galactosidase beta 1	Homo sapiens	50-68
3038688-3	1987	It is retained in the host by the presence of ampicillin, and each inserted promoter yielded consistent values of beta Gal activity under all the conditions tested.	Ampicillin	46-56	galactosidase beta 1	Homo sapiens	114-122
2438419-3	1986	Amino-terminal analysis of a transposase-beta-galactosidase fusion protein gave the sequence Met-Ile-Thr-Ser-Ala, which corresponds to the predicted amino acid sequence starting at position 93 of IS50.	Met-Ile-Thr	93-104	galactosidase beta 1	Homo sapiens	41-59
3109975-6	1987	SDS-polyacrylamide gel electrophoresis of the beta-galactosidase showed three protein bands with molecular weights of 63,000, 31,000 and 20,000.	sds-polyacrylamide	0-18	galactosidase beta 1	Homo sapiens	46-64
3119960-0	1987	Disaccharide synthesis with immobilized beta-galactosidase.	Disaccharides	0-12	galactosidase beta 1	Homo sapiens	40-58
3331711-3	1987	Starting with clones identified as efficient producers of beta-galactosidase on indicator agar plates, the coding sequence for hpreproPTH was reconstituted intact.	Agar	90-94	galactosidase beta 1	Homo sapiens	58-76
3098853-2	1986	In the assay a beta 2-microglobulin-beta-galactosidase conjugate competes with beta 2-microglobulin from the sample for the binding to anti-beta 2-microglobulin antibodies bound to small size agarose particles (micro-Sepharose) via a double antibody.	Sepharose	192-199	galactosidase beta 1	Homo sapiens	36-54
2438419-3	1986	Amino-terminal analysis of a transposase-beta-galactosidase fusion protein gave the sequence Met-Ile-Thr-Ser-Ala, which corresponds to the predicted amino acid sequence starting at position 93 of IS50.	Serine	105-108	galactosidase beta 1	Homo sapiens	41-59
3098853-2	1986	In the assay a beta 2-microglobulin-beta-galactosidase conjugate competes with beta 2-microglobulin from the sample for the binding to anti-beta 2-microglobulin antibodies bound to small size agarose particles (micro-Sepharose) via a double antibody.	Sepharose	217-226	galactosidase beta 1	Homo sapiens	36-54
2438419-3	1986	Amino-terminal analysis of a transposase-beta-galactosidase fusion protein gave the sequence Met-Ile-Thr-Ser-Ala, which corresponds to the predicted amino acid sequence starting at position 93 of IS50.	Alanine	109-112	galactosidase beta 1	Homo sapiens	41-59
3098853-4	1986	This is achieved by the heterobifunctional reagent SPDP and the subsequent linkage of the formed derivative to beta-galactosidase by a thioldisulphide exchange reaction.	thioldisulphide	135-150	galactosidase beta 1	Homo sapiens	111-129
3829205-7	1986	Presently, we have isolated polylactosaminyl lipids from HEMPAS blood cells and analyzed their structures by fast atom bombardment-mass spectrometry (FAB-MS), methylation analysis, endo-beta-galactosidase digestion.	polylactosaminyl lipids	28-51	galactosidase beta 1	Homo sapiens	186-204
2430799-2	1986	Conditions were established for desulphation of hexa-, octa-, deca- and larger oligosaccharides derived from corneal keratan sulphate after treatment with endo-beta-galactosidase.	Oligosaccharides	79-95	galactosidase beta 1	Homo sapiens	160-178
2430799-2	1986	Conditions were established for desulphation of hexa-, octa-, deca- and larger oligosaccharides derived from corneal keratan sulphate after treatment with endo-beta-galactosidase.	Keratan Sulfate	117-133	galactosidase beta 1	Homo sapiens	160-178
3100590-0	1986	Effect of various conditions on the formation of oligosaccharides in milk treated with beta-galactosidase.	Oligosaccharides	49-65	galactosidase beta 1	Homo sapiens	87-105
3101480-0	1987	Lactose digestion by yogurt beta-galactosidase: influence of pH and microbial cell integrity.	Lactose	0-7	galactosidase beta 1	Homo sapiens	28-46
3092188-5	1986	In a construct for producing beta-galactosidase, the effects on translational yields of the tri-nucleotide 5" to the initiation codon are dependent on the entire triplet.	tri-nucleotide	92-106	galactosidase beta 1	Homo sapiens	29-47
3101480-1	1987	Lactase-deficient subjects more effectively digest lactose in yogurt than lactose in other dairy products, apparently due to yogurt microbial beta-galactosidase (beta-gal) which is active in the GI tract.	Lactose	51-58	galactosidase beta 1	Homo sapiens	142-160
3101480-1	1987	Lactase-deficient subjects more effectively digest lactose in yogurt than lactose in other dairy products, apparently due to yogurt microbial beta-galactosidase (beta-gal) which is active in the GI tract.	Lactose	51-58	galactosidase beta 1	Homo sapiens	142-150
3101480-1	1987	Lactase-deficient subjects more effectively digest lactose in yogurt than lactose in other dairy products, apparently due to yogurt microbial beta-galactosidase (beta-gal) which is active in the GI tract.	Lactose	74-81	galactosidase beta 1	Homo sapiens	142-160
3093179-1	1986	The fluorogenic substrate fluorescein-di-beta-D-galactopyranoside was used to detect acid beta-galactosidase in intact cultured human fibroblasts.	fluorescein-digalactoside	26-65	galactosidase beta 1	Homo sapiens	90-108
3093179-4	1986	Within one control cell population there was a positive correlation between the amount of accumulated intracellular fluorescein fluorescence and the specific acid beta-galactosidase activity as measured biochemically on sorted cells from different zones of the fluorescence distribution.	Fluorescein	116-127	galactosidase beta 1	Homo sapiens	163-181
2432161-2	1986	Inhibitors of both gyrase subunits, nalidixic acid and novobiocin, affect the expression of cysB, as monitored by beta-galactosidase activity in cysB::lac fusion strains.	Nalidixic Acid	36-50	galactosidase beta 1	Homo sapiens	114-132
2432161-2	1986	Inhibitors of both gyrase subunits, nalidixic acid and novobiocin, affect the expression of cysB, as monitored by beta-galactosidase activity in cysB::lac fusion strains.	Novobiocin	55-65	galactosidase beta 1	Homo sapiens	114-132
3092133-4	1986	Therefore, the adult disorder must be due to a mutation of the structural gene for beta-galactosidase, which is allelic to the mutations in type 1 GM1 gangliosidosis and Morquio B syndrome.	G(M1) Ganglioside	147-150	galactosidase beta 1	Homo sapiens	83-101
3084467-0	1986	Urinary endo-beta-galactosidase capable of depolymerizing polylactosaminoglycans.	lactosaminoglycan	58-80	galactosidase beta 1	Homo sapiens	13-31
3765107-6	1986	NR, AO and NH4+ accumulation in cells resulted in inhibition of the activity of the following lysosomal hydrolases: cathepsins B and D, acid lipase, N-acetyl-beta,D-glucosaminidase, beta-galactosidase, acid phosphatase and galactosyltransferase, the latter being a marker of Golgi apparatus.	Acridine Orange	4-6	galactosidase beta 1	Homo sapiens	182-200
3765107-6	1986	NR, AO and NH4+ accumulation in cells resulted in inhibition of the activity of the following lysosomal hydrolases: cathepsins B and D, acid lipase, N-acetyl-beta,D-glucosaminidase, beta-galactosidase, acid phosphatase and galactosyltransferase, the latter being a marker of Golgi apparatus.	Ammonium Compounds	11-15	galactosidase beta 1	Homo sapiens	182-200
3524437-5	1986	Unbound FDR was hydrolyzed by beta-galactosidase to release a fluorescent product that is proportional to the kanamycin concentration in the sample.	Kanamycin	110-119	galactosidase beta 1	Homo sapiens	30-48
3084467-5	1986	The oligosaccharide profiles produced from various keratan sulfates and erythroglycan by the action of urinary endo-beta-galactosidase are quite similar to those produced by Escherichia freundii endo-beta-galactosidase (Nakagawa, H., Yamada, T., Chien, J.-L., Gardas, A., Kitamikado, M., Li, S.-C., and Li, Y.-T. (1980) J. Biol.	Oligosaccharides	4-19	galactosidase beta 1	Homo sapiens	116-134
3084467-5	1986	The oligosaccharide profiles produced from various keratan sulfates and erythroglycan by the action of urinary endo-beta-galactosidase are quite similar to those produced by Escherichia freundii endo-beta-galactosidase (Nakagawa, H., Yamada, T., Chien, J.-L., Gardas, A., Kitamikado, M., Li, S.-C., and Li, Y.-T. (1980) J. Biol.	Oligosaccharides	4-19	galactosidase beta 1	Homo sapiens	200-218
3084467-5	1986	The oligosaccharide profiles produced from various keratan sulfates and erythroglycan by the action of urinary endo-beta-galactosidase are quite similar to those produced by Escherichia freundii endo-beta-galactosidase (Nakagawa, H., Yamada, T., Chien, J.-L., Gardas, A., Kitamikado, M., Li, S.-C., and Li, Y.-T. (1980) J. Biol.	Keratan Sulfate	51-67	galactosidase beta 1	Homo sapiens	116-134
3084467-5	1986	The oligosaccharide profiles produced from various keratan sulfates and erythroglycan by the action of urinary endo-beta-galactosidase are quite similar to those produced by Escherichia freundii endo-beta-galactosidase (Nakagawa, H., Yamada, T., Chien, J.-L., Gardas, A., Kitamikado, M., Li, S.-C., and Li, Y.-T. (1980) J. Biol.	Keratan Sulfate	51-67	galactosidase beta 1	Homo sapiens	200-218
3084467-8	1986	The presence of urinary endo-beta-galactosidase indicates the existence of a new catabolic pathway for polylactosaminoglycans.	lactosaminoglycan	103-125	galactosidase beta 1	Homo sapiens	29-47
3084467-1	1986	Human urine was found to contain an endo-beta-galactosidase capable of depolymerizing sulfated and non-sulfated polylactosaminoglycans.	lactosaminoglycan	112-134	galactosidase beta 1	Homo sapiens	41-59
3086209-5	1986	Fibroblasts from different types of galactosialidosis, a recessive disease associated with a coexistent beta-galactosidase/neuraminidase deficiency all showed degradation of ingested GM1.	G(M1) Ganglioside	183-186	galactosidase beta 1	Homo sapiens	104-122
3086297-7	1986	A rabbit anti-blasticidin S (BLS) antiserum analyzed by the present method using beta-galactosidase-labeled BLS as the labeled ligand was found to be fairly homogeneous with respect to the affinity and to have a binding constant of 1.48 +/- 0.24 (S.D.)	blasticidin S	14-27	galactosidase beta 1	Homo sapiens	81-99
3088498-5	1986	Treatment with endo-beta-galactosidase showed that the stored material contained N-acetyllactosamine repeating units.	N-acetyllactosamine	81-100	galactosidase beta 1	Homo sapiens	20-38
3088498-7	1986	Treatment with exo-beta-galactosidase transformed the trisaccharide OS II into the disaccharide OS I, indicating that the deficiency of beta-galactosidase in GM1 gangliosidosis type I, but not in type II, also affects glycoprotein catabolism, leading to the accumulation of glycopeptides containing terminal beta-galactosyl residues and N-acetyllactosamine repeating units.	trisaccharide os ii	54-73	galactosidase beta 1	Homo sapiens	19-37
3088498-7	1986	Treatment with exo-beta-galactosidase transformed the trisaccharide OS II into the disaccharide OS I, indicating that the deficiency of beta-galactosidase in GM1 gangliosidosis type I, but not in type II, also affects glycoprotein catabolism, leading to the accumulation of glycopeptides containing terminal beta-galactosyl residues and N-acetyllactosamine repeating units.	disaccharide os i	83-100	galactosidase beta 1	Homo sapiens	19-37
3088498-7	1986	Treatment with exo-beta-galactosidase transformed the trisaccharide OS II into the disaccharide OS I, indicating that the deficiency of beta-galactosidase in GM1 gangliosidosis type I, but not in type II, also affects glycoprotein catabolism, leading to the accumulation of glycopeptides containing terminal beta-galactosyl residues and N-acetyllactosamine repeating units.	G(M1) Ganglioside	158-161	galactosidase beta 1	Homo sapiens	19-37
3088498-7	1986	Treatment with exo-beta-galactosidase transformed the trisaccharide OS II into the disaccharide OS I, indicating that the deficiency of beta-galactosidase in GM1 gangliosidosis type I, but not in type II, also affects glycoprotein catabolism, leading to the accumulation of glycopeptides containing terminal beta-galactosyl residues and N-acetyllactosamine repeating units.	Glycopeptides	274-287	galactosidase beta 1	Homo sapiens	19-37
3088498-7	1986	Treatment with exo-beta-galactosidase transformed the trisaccharide OS II into the disaccharide OS I, indicating that the deficiency of beta-galactosidase in GM1 gangliosidosis type I, but not in type II, also affects glycoprotein catabolism, leading to the accumulation of glycopeptides containing terminal beta-galactosyl residues and N-acetyllactosamine repeating units.	N-acetyllactosamine	337-356	galactosidase beta 1	Homo sapiens	19-37
3084137-2	1986	Culture for 5 days with thiol protease inhibitors such as leupeptin, E-64 or Z-Phe-Phe-CHN2 partially restored the beta-galactosidase activity of fibroblasts from patients, but did not affect the beta-galactosidase activity of fibroblasts from control subjects.	leupeptin	58-67	galactosidase beta 1	Homo sapiens	115-133
3146011-3	1986	Differences were observed in the induction factors of these samples when p-nitrophenyl-beta-D-galactopyranoside (p-NPG) and o-nitrophenyl-beta-D-galactopyranoside (o-NPG) were used as substrates for the beta-galactosidase assay in the SOS Chromotest.	2-nitrophenylgalactoside	124-162	galactosidase beta 1	Homo sapiens	203-221
3146011-3	1986	Differences were observed in the induction factors of these samples when p-nitrophenyl-beta-D-galactopyranoside (p-NPG) and o-nitrophenyl-beta-D-galactopyranoside (o-NPG) were used as substrates for the beta-galactosidase assay in the SOS Chromotest.	4-nitrophenylgalactoside	73-111	galactosidase beta 1	Homo sapiens	203-221
2881844-8	1986	The beta-galactosidase fusion proteins produced from the LacZ+ recombinants are identified on sodium dodecyl sulfate polyacrylamide gels by their large size and high level of production.	Sodium Dodecyl Sulfate	94-116	galactosidase beta 1	Homo sapiens	4-22
3084462-4	1986	Acid beta-galactosidase was characterized as a thiol enzyme which was inactivated by a mercuric compound.	Sulfhydryl Compounds	47-52	galactosidase beta 1	Homo sapiens	0-23
3084462-6	1986	The microscale purification system using Con A-Sepharose, PAT-Sepharose, and Hg-agarose column chromatography achieved 565- and 7,970-fold purifications of acid beta-galactosidase with an overall yields of 44% and 45% from normal and GM1-gangliosidosis fibroblasts, respectively.	Sepharose	80-87	galactosidase beta 1	Homo sapiens	156-179
3082241-4	1986	In addition, beta-galactosidase activity was successfully determined with [3H]galactosylceramide as the enzyme substrate; the Km was 18.73 mM and the Vmax was 11.63 nmol/mg/h, indicating that no significant structural modification occurs during the oxidation.	[3h]galactosylceramide	74-96	galactosidase beta 1	Homo sapiens	13-31
3517989-2	1986	Nicotine enzyme immunoassay has been developed for the first time using antibodies produced against 6-epsilon-aminocapramido -DL-nicotine and beta-galactosidase nicotine enzyme.	Nicotine	0-8	galactosidase beta 1	Homo sapiens	142-160
3003205-4	1986	Removal of terminal beta-linked galactose from the HeLa cell surface with beta-galactosidase increased toxin binding and activity, and it also potentiated the effects of lysozyme and wheat-germ agglutinin, which recognize oligomeric beta 1----4-linked N-acetyl-D-glucosamine and inhibit toxin activity as well.	beta-linked galactose	20-41	galactosidase beta 1	Homo sapiens	74-92
3003205-6	1986	Effects of beta-galactosidase were reversed by readdition of galactose to cell-surface oligosaccharide acceptors.	Galactose	61-70	galactosidase beta 1	Homo sapiens	11-29
3003205-6	1986	Effects of beta-galactosidase were reversed by readdition of galactose to cell-surface oligosaccharide acceptors.	Oligosaccharides	87-102	galactosidase beta 1	Homo sapiens	11-29
3104141-3	1986	Viruses synthesizing beta Gal were determined by utilizing the chromogenic substrate, 5-bromo-4-chloro-3-indoyl-beta-D-galactoside to form blue plaques.	5-bromo-4-chloro-3-indoyl-beta-d-galactoside	86-130	galactosidase beta 1	Homo sapiens	21-29
2881844-8	1986	The beta-galactosidase fusion proteins produced from the LacZ+ recombinants are identified on sodium dodecyl sulfate polyacrylamide gels by their large size and high level of production.	polyacrylamide	117-131	galactosidase beta 1	Homo sapiens	4-22
3934152-6	1985	The purified beta-galactosidase had galactosylceramidase II activity, which was competitively inhibited by GM1 ganglioside.	G(M1) Ganglioside	107-122	galactosidase beta 1	Homo sapiens	13-31
3086147-1	1986	Sucrose gradient centrifugation of the monomeric form (A1) of porcine spleen beta-galactosidase showed a pH-dependent equilibrium between monomer at neutral pH (pH 7.0) and dimer at acidic pH (pH 5.4-3.0), independent of ionic strength.	Sucrose	0-7	galactosidase beta 1	Homo sapiens	77-95
3531895-2	1986	Parallely the change of mutagenic activity of decomposing mixture was studied by SOS chromotest (in which the change of beta-galactosidase was observed).	sulfur monoxide	81-84	galactosidase beta 1	Homo sapiens	120-138
3934152-7	1985	Thus, galactosylceramidase II seems to be identical to GM1 ganglioside beta-galactosidase and lactosylceramidase II.	G(M1) Ganglioside	55-70	galactosidase beta 1	Homo sapiens	71-89
3005249-5	1985	It was found that these sugar chains comprise about 40% of total alkali-labile oligosaccharides of asialo GP-2 and contain endo-beta-galactosidase (Flavobacterium keratolyticus)-resistant highly branched and heterogeneous oligosaccharides of poly-N-acetyllactosamine type which are linked O-glycosidically to the peptide backbone through N-acetylgalactosamine.	Sugars	24-29	galactosidase beta 1	Homo sapiens	128-146
3005249-5	1985	It was found that these sugar chains comprise about 40% of total alkali-labile oligosaccharides of asialo GP-2 and contain endo-beta-galactosidase (Flavobacterium keratolyticus)-resistant highly branched and heterogeneous oligosaccharides of poly-N-acetyllactosamine type which are linked O-glycosidically to the peptide backbone through N-acetylgalactosamine.	Oligosaccharides	222-238	galactosidase beta 1	Homo sapiens	128-146
3005249-5	1985	It was found that these sugar chains comprise about 40% of total alkali-labile oligosaccharides of asialo GP-2 and contain endo-beta-galactosidase (Flavobacterium keratolyticus)-resistant highly branched and heterogeneous oligosaccharides of poly-N-acetyllactosamine type which are linked O-glycosidically to the peptide backbone through N-acetylgalactosamine.	poly-N-acetyllactosamine	242-266	galactosidase beta 1	Homo sapiens	128-146
3005249-5	1985	It was found that these sugar chains comprise about 40% of total alkali-labile oligosaccharides of asialo GP-2 and contain endo-beta-galactosidase (Flavobacterium keratolyticus)-resistant highly branched and heterogeneous oligosaccharides of poly-N-acetyllactosamine type which are linked O-glycosidically to the peptide backbone through N-acetylgalactosamine.	Acetylgalactosamine	338-359	galactosidase beta 1	Homo sapiens	128-146
3930908-2	1985	Treatment of the lipids with graded neuraminidase and beta-galactosidase, gas chromatographic analysis of their carbohydrates, sphingosine bases and molecular species of sialic acid revealed that the structure of these gangliosides were GM3(NeuAc), GM3(NeuGc), GD3(NeuAc) and GD3(NeuGc), each of which was 16 +/- 2 micrograms, 304 +/- 42 micrograms, 30 +/- 3 micrograms and 240 +/- 26 micrograms, respectively, per gram of the dry erythrocyte stroma.	Gangliosides	219-231	galactosidase beta 1	Homo sapiens	54-72
2933078-4	1985	In addition, it was susceptible to degradation by keratan sulphate endo-beta-galactosidase and thus was assumed to be keratan sulphate.	Keratan Sulfate	50-66	galactosidase beta 1	Homo sapiens	72-90
2933078-4	1985	In addition, it was susceptible to degradation by keratan sulphate endo-beta-galactosidase and thus was assumed to be keratan sulphate.	Keratan Sulfate	118-134	galactosidase beta 1	Homo sapiens	72-90
3935648-1	1985	A solid-phase enzyme immunoassay for thromboxane B2 was developed using a conjugate of thromboxane B2 and beta-galactosidase.	Thromboxane B2	37-51	galactosidase beta 1	Homo sapiens	106-124
3935648-3	1985	Then, the specifically bound beta-galactosidase was assayed fluorimetrically, and the enzyme activity was correlated with the amount of unlabeled thromboxane B2.	Thromboxane B2	146-160	galactosidase beta 1	Homo sapiens	29-47
3931638-0	1985	m-Fluorotyrosine substitution in beta-galactosidase; evidence for the existence of a catalytically active tyrosine.	fluorotyrosine	2-16	galactosidase beta 1	Homo sapiens	33-51
3931638-0	1985	m-Fluorotyrosine substitution in beta-galactosidase; evidence for the existence of a catalytically active tyrosine.	Tyrosine	8-16	galactosidase beta 1	Homo sapiens	33-51
3931638-1	1985	The pH profiles of beta-galactosidase, having tyr replaced by m-fluorotyrosine, were compared to those of normal enzyme.	Tyrosine	46-49	galactosidase beta 1	Homo sapiens	19-37
3931638-1	1985	The pH profiles of beta-galactosidase, having tyr replaced by m-fluorotyrosine, were compared to those of normal enzyme.	3-fluorotyrosine	62-78	galactosidase beta 1	Homo sapiens	19-37
3931638-5	1985	This shows that a tyr in beta-galactosidase is a general-acid catalyst in the glycosidic bond breaking reaction and a tyr (probably the same one) is a general-base catalyst in the hydrolytic reaction.	Tyrosine	18-21	galactosidase beta 1	Homo sapiens	25-43
3931638-5	1985	This shows that a tyr in beta-galactosidase is a general-acid catalyst in the glycosidic bond breaking reaction and a tyr (probably the same one) is a general-base catalyst in the hydrolytic reaction.	Tyrosine	118-121	galactosidase beta 1	Homo sapiens	25-43
2415273-2	1985	With a previously reported, simple and sensitive fluorometric assay for GM1 ganglioside beta-galactosidase using high performance liquid chromatography (HPLC), optimal reaction conditions were determined for the assay of acid beta-galactosidase activity toward asialofetuin in skin fibroblast homogenates.	G(M1) Ganglioside	72-87	galactosidase beta 1	Homo sapiens	88-106
2415273-2	1985	With a previously reported, simple and sensitive fluorometric assay for GM1 ganglioside beta-galactosidase using high performance liquid chromatography (HPLC), optimal reaction conditions were determined for the assay of acid beta-galactosidase activity toward asialofetuin in skin fibroblast homogenates.	G(M1) Ganglioside	72-87	galactosidase beta 1	Homo sapiens	226-244
3929841-1	1985	A solid-phase enzyme immunoassay of 6-ketoprostaglandin F1 alpha (a stable degradation product of prostaglandin I2) was developed in which the hapten molecule was labeled with beta-galactosidase.	6-ketoprostaglandin	36-55	galactosidase beta 1	Homo sapiens	176-194
3929841-1	1985	A solid-phase enzyme immunoassay of 6-ketoprostaglandin F1 alpha (a stable degradation product of prostaglandin I2) was developed in which the hapten molecule was labeled with beta-galactosidase.	Epoprostenol	98-114	galactosidase beta 1	Homo sapiens	176-194
3929841-3	1985	The activity of the immunologically bound beta-galactosidase was assayed by fluorometry, and correlated with the amount of unlabeled 6-ketoprostaglandin F1 alpha.	6-ketoprostaglandin	133-152	galactosidase beta 1	Homo sapiens	42-60
4067042-3	1985	The principle of the Boehringer-Mannheim method is presented, i.e., lactose is hydrolyzed to glucose and beta-galactose in the presence of beta-galactosidase and water.	Lactose	68-75	galactosidase beta 1	Homo sapiens	139-157
4067042-3	1985	The principle of the Boehringer-Mannheim method is presented, i.e., lactose is hydrolyzed to glucose and beta-galactose in the presence of beta-galactosidase and water.	Glucose	93-100	galactosidase beta 1	Homo sapiens	139-157
4067042-3	1985	The principle of the Boehringer-Mannheim method is presented, i.e., lactose is hydrolyzed to glucose and beta-galactose in the presence of beta-galactosidase and water.	beta-D-galactose	105-119	galactosidase beta 1	Homo sapiens	139-157
6096007-3	1984	The implication that the sequence element around Lys-128 acts as an autonomous signal capable of specifying nuclear location was tested directly by transferring it to the amino termini of beta-galactosidase and of pyruvate kinase, normally a cytoplasmic protein.	Lysine	49-52	galactosidase beta 1	Homo sapiens	188-206
2410029-2	1985	Macromolecular beta-galactosidase substrates were prepared by attaching o-nitrophenyl-beta-galactoside to carboxymethyldextran with positively charged linking groups.	2-nitrophenylgalactoside	72-102	galactosidase beta 1	Homo sapiens	15-33
2410029-2	1985	Macromolecular beta-galactosidase substrates were prepared by attaching o-nitrophenyl-beta-galactoside to carboxymethyldextran with positively charged linking groups.	carboxymethyl dextran	106-126	galactosidase beta 1	Homo sapiens	15-33
3891865-3	1985	The use of beta-galactosidase-monosaccharide-phenytoin derivatives in the development of sensitive phenytoin enzyme immunoassays is described and the assays are compared with hapten-heterologous, site-heterologous and homologous phenytoin enzyme immunoassays prepared using other phenytoin derivatives.	Phenytoin	45-54	galactosidase beta 1	Homo sapiens	11-29
3922758-6	1985	Sucrose density gradient centrifugation experiments demonstrate that the neuraminidase activity is exclusively present in a high density multimeric form of beta-galactosidase.	Sucrose	0-7	galactosidase beta 1	Homo sapiens	156-174
4026310-7	1985	Digestion with neuraminidase and beta-galactosidase of the O-linked oligosaccharides supported the idea that the common disaccharide core was mainly of the structure beta-galactosyl-N-acetylgalactosamine.	o-linked oligosaccharides	59-84	galactosidase beta 1	Homo sapiens	33-51
4026310-7	1985	Digestion with neuraminidase and beta-galactosidase of the O-linked oligosaccharides supported the idea that the common disaccharide core was mainly of the structure beta-galactosyl-N-acetylgalactosamine.	Disaccharides	120-132	galactosidase beta 1	Homo sapiens	33-51
3157598-3	1985	By measuring fluorescence emitted from the hydrolyzed product by beta-galactosidase of 4-methylumbelliferyl-beta-D-galactoside, it has become possible to quantify a few picograms of specific DNA in DNA samples immobilized in plastic microtiter wells.	4-methylumbelliferyl-galactopyranoside	87-126	galactosidase beta 1	Homo sapiens	65-83
3920213-8	1985	Removal of polylactosamine sequences from the former glycopeptide by endo-beta-galactosidase digestion caused the elution peak for this fraction to change from 2.0 to 2.5 M, the same as for the complex N-linked carbohydrate-containing glycopeptide.	polylactosamine	11-26	galactosidase beta 1	Homo sapiens	74-92
3920213-8	1985	Removal of polylactosamine sequences from the former glycopeptide by endo-beta-galactosidase digestion caused the elution peak for this fraction to change from 2.0 to 2.5 M, the same as for the complex N-linked carbohydrate-containing glycopeptide.	Glycopeptides	53-65	galactosidase beta 1	Homo sapiens	74-92
3917866-5	1985	In parallel studies, a glycolipid-enriched extract from U937 cells, a human macrophage-like cell line, known to enhance the monocyte response to MIF, lost this activity when treated with neuraminidase and alpha-L-fucosidase, but not with beta-galactosidase.	Glycolipids	23-33	galactosidase beta 1	Homo sapiens	238-256
3919971-3	1985	Incubating cells with 0.5 or 1.0 mmol/l cysteamine, a substance used in the clinical treatment of cystinosis because it depletes cells of excess cystine, greatly decreased beta-galactosidase activity in both cystinotic and normal cells.	Cysteamine	40-50	galactosidase beta 1	Homo sapiens	172-190
3919971-5	1985	Thus, cysteamine, although effective in depleting cystinotic cells of excess cystine, may have the undesired side-effect of severely decreasing lysosomal beta-galactosidase.	Cysteamine	6-16	galactosidase beta 1	Homo sapiens	154-172
6239876-7	1984	Further treatment of von Willebrand factor with neuraminidase and beta-galactosidase reduced the D-galactose to 15% and ristocetin cofactor activity to 57%.	Galactose	97-108	galactosidase beta 1	Homo sapiens	66-84
6099327-1	1984	The versatility of insertional inactivation of beta-galactosidase activity for subcloning and sequencing has been enhanced by combining a chemically synthesized oligonucleotide which specifies nine 6-bp-cutter restriction sites including BglII, XhoI, NruI, ClaI, SacI and EcoRV in various configurations with existing polylinkers to create a set of highly versatile cloning sites.	Oligonucleotides	161-176	galactosidase beta 1	Homo sapiens	47-65
6239876-7	1984	Further treatment of von Willebrand factor with neuraminidase and beta-galactosidase reduced the D-galactose to 15% and ristocetin cofactor activity to 57%.	Ristocetin	120-130	galactosidase beta 1	Homo sapiens	66-84
6239876-8	1984	A similar decrease in ristocetin cofactor activity was seen if von Willebrand factor was treated only with neuraminidase and beta-galactosidase.	Ristocetin	22-32	galactosidase beta 1	Homo sapiens	125-143
6094178-9	1984	Chromatography of the oligosaccharides on Bio-Gel P6 and Concanavalin A columns indicated a spectrum of oligosaccharides which include those of high mannose type labelled with [3H]glucosamine, and a mixture of oligosaccharides labelled with [3H]fucose and [3H]glucosamine of bi- and multiantennary complex types of which a subpopulation is susceptible to digestion with endo-beta-galactosidase.	Oligosaccharides	22-38	galactosidase beta 1	Homo sapiens	375-393
6431970-5	1984	It could be converted to a sharper band (apparent Mr 23000) by treatment with endo-beta-galactosidase from Bacteroides fragilis and so probably contains one or more sites at which an oligosaccharide of the poly(N-acetyl-lactosamine) type is attached.	Oligosaccharides	183-198	galactosidase beta 1	Homo sapiens	83-101
6094178-7	1984	A proportion of [3H]fucose-labelled glycopeptides was susceptible to endo-beta-galactosidase, confirming the immunoblotting experiment using antibodies against the Lea and the difucosylated Type 2 antigenic determinants.	Tritium	17-19	galactosidase beta 1	Homo sapiens	74-92
6094178-7	1984	A proportion of [3H]fucose-labelled glycopeptides was susceptible to endo-beta-galactosidase, confirming the immunoblotting experiment using antibodies against the Lea and the difucosylated Type 2 antigenic determinants.	Fucose	20-26	galactosidase beta 1	Homo sapiens	74-92
6094178-7	1984	A proportion of [3H]fucose-labelled glycopeptides was susceptible to endo-beta-galactosidase, confirming the immunoblotting experiment using antibodies against the Lea and the difucosylated Type 2 antigenic determinants.	Glycopeptides	36-49	galactosidase beta 1	Homo sapiens	74-92
6736034-2	1984	The glycopeptides were digested by endo-beta-galactosidase under various conditions and oligosaccharides and core glycopeptides thus obtained and intact glycopeptides were analyzed by methylation, exoglycosidase digestion, and fast atom bombardment mass spectrometry.	Glycopeptides	4-17	galactosidase beta 1	Homo sapiens	40-58
6435528-10	1984	When SAP-1 from GM1 gangliosidosis liver was treated sequentially with neuraminidase, beta-galactosidase, and endoglycosidase D, almost all of it was converted to the forms found in control human liver.	G(M1) Ganglioside	16-19	galactosidase beta 1	Homo sapiens	86-104
18553475-0	1984	Hydrolysis of milk lactose by immobilized beta-galactosidase-hen egg white powder.	Lactose	19-26	galactosidase beta 1	Homo sapiens	42-60
18553475-1	1984	Immobilized beta-galactosidase was obtained by crosslinking the enzyme with hen egg white using 2% glutaraldehyde.	Glutaral	99-113	galactosidase beta 1	Homo sapiens	12-30
6432371-0	1984	Application of a GM1 ganglioside beta-galactosidase microassay method to diagnosis of GM1 gangliosidosis.	G(M1) Ganglioside	17-20	galactosidase beta 1	Homo sapiens	33-51
6432371-1	1984	The enzymatic diagnosis of GM1 gangliosidosis, including the diagnosis of heterozygosity, requires a microassay of GM1 ganglioside beta-galactosidase activity in lymphocytes and cultured skin fibroblasts.	G(M1) Ganglioside	115-130	galactosidase beta 1	Homo sapiens	131-149
6432371-3	1984	Reaction conditions were examined to determine those optimal for the assay of GM1 ganglioside beta-galactosidase activity in lymphocyte and skin fibroblast homogenates.	G(M1) Ganglioside	78-93	galactosidase beta 1	Homo sapiens	94-112
6435475-0	1984	A fluorometric microassay procedure for monitoring the enzymatic activity of GM1-ganglioside beta-galactosidase by use of high-performance liquid chromatography.	G(M1) Ganglioside	77-80	galactosidase beta 1	Homo sapiens	93-111
6435475-1	1984	For the measurement of the enzymatic activity of GM1-ganglioside (II3 NeuAcGgOse4Cer, galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminosyl) galactosyl-glucosylceramide) beta-galactosidase in crude enzyme samples, a microassay using nonradioisotopic GM1-ganglioside was devised.	G(M1) Ganglioside	49-64	galactosidase beta 1	Homo sapiens	172-190
6435475-1	1984	For the measurement of the enzymatic activity of GM1-ganglioside (II3 NeuAcGgOse4Cer, galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminosyl) galactosyl-glucosylceramide) beta-galactosidase in crude enzyme samples, a microassay using nonradioisotopic GM1-ganglioside was devised.	galactosyl-n-acetylgalactosaminyl-(n-acetylneuraminosyl) galactosyl-glucosylceramide	86-170	galactosidase beta 1	Homo sapiens	172-190
6431970-5	1984	It could be converted to a sharper band (apparent Mr 23000) by treatment with endo-beta-galactosidase from Bacteroides fragilis and so probably contains one or more sites at which an oligosaccharide of the poly(N-acetyl-lactosamine) type is attached.	poly-N-acetyllactosamine	206-231	galactosidase beta 1	Homo sapiens	83-101
6431970-7	1984	Cleavage of the intact, endo-beta-galactosidase-treated, photoaffinity-labelled protein at its cysteine residues with 2-nitro-5-thiocyanobenzoic acid yielded a prominent, unlabelled fragment of apparent Mr 38000 and several smaller fragments which stained less intensely on SDS/polyacrylamide gels.	Cysteine	95-103	galactosidase beta 1	Homo sapiens	29-47
6431970-7	1984	Cleavage of the intact, endo-beta-galactosidase-treated, photoaffinity-labelled protein at its cysteine residues with 2-nitro-5-thiocyanobenzoic acid yielded a prominent, unlabelled fragment of apparent Mr 38000 and several smaller fragments which stained less intensely on SDS/polyacrylamide gels.	2-nitro-5-thiocyanobenzoic acid	118-149	galactosidase beta 1	Homo sapiens	29-47
6431970-7	1984	Cleavage of the intact, endo-beta-galactosidase-treated, photoaffinity-labelled protein at its cysteine residues with 2-nitro-5-thiocyanobenzoic acid yielded a prominent, unlabelled fragment of apparent Mr 38000 and several smaller fragments which stained less intensely on SDS/polyacrylamide gels.	Sodium Dodecyl Sulfate	274-277	galactosidase beta 1	Homo sapiens	29-47
6431970-7	1984	Cleavage of the intact, endo-beta-galactosidase-treated, photoaffinity-labelled protein at its cysteine residues with 2-nitro-5-thiocyanobenzoic acid yielded a prominent, unlabelled fragment of apparent Mr 38000 and several smaller fragments which stained less intensely on SDS/polyacrylamide gels.	polyacrylamide	278-292	galactosidase beta 1	Homo sapiens	29-47
6436145-1	1984	A one-step purification method of hybrid proteins exhibiting beta-galactosidase activity, based on affinity chromatography in the presence of high salt concentration, is described.	Salts	147-151	galactosidase beta 1	Homo sapiens	61-79
6431895-0	1984	The role of lysosomal sialidase and beta-galactosidase in processing the complex carbohydrate chains on lysosomal enzymes and possibly other glycoproteins.	Carbohydrates	81-93	galactosidase beta 1	Homo sapiens	36-54
6431895-1	1984	Previous studies using the lectin RCA-I from Ricinus communis have indicated that several lysosomal enzymes in the fibroblasts of patients deficient in beta-galactosidase carry excess terminal galactose.	Galactose	193-202	galactosidase beta 1	Homo sapiens	152-170
6431895-3	1984	In this paper we confirm, using Jack-bean beta-galactosidase, that the binding to RCA-I of the purified N-acetyl-beta-D-hexosaminidase from a patient with GM1 gangliosidosis depends on a terminal beta-linked galactose.	rca-i	82-87	galactosidase beta 1	Homo sapiens	42-60
6431895-3	1984	In this paper we confirm, using Jack-bean beta-galactosidase, that the binding to RCA-I of the purified N-acetyl-beta-D-hexosaminidase from a patient with GM1 gangliosidosis depends on a terminal beta-linked galactose.	beta-linked galactose	196-217	galactosidase beta 1	Homo sapiens	42-60
6232275-8	1984	Me-GM1 and HO-GM1 could be hydrolyzed by human hepatic beta-galactosidase in the presence of GM1-activator at rates comparable to that of the native GM1.	me-gm1	0-6	galactosidase beta 1	Homo sapiens	55-73
6232275-8	1984	Me-GM1 and HO-GM1 could be hydrolyzed by human hepatic beta-galactosidase in the presence of GM1-activator at rates comparable to that of the native GM1.	ho-gm1	11-17	galactosidase beta 1	Homo sapiens	55-73
6232275-8	1984	Me-GM1 and HO-GM1 could be hydrolyzed by human hepatic beta-galactosidase in the presence of GM1-activator at rates comparable to that of the native GM1.	G(M1) Ganglioside	3-6	galactosidase beta 1	Homo sapiens	55-73
6232275-8	1984	Me-GM1 and HO-GM1 could be hydrolyzed by human hepatic beta-galactosidase in the presence of GM1-activator at rates comparable to that of the native GM1.	G(M1) Ganglioside	14-17	galactosidase beta 1	Homo sapiens	55-73
6325875-3	1984	Recombinant viruses were selected as blue plaques in the presence of a beta-galactosidase indicator, 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside.	5-bromo-4-chloro-3-indolyl beta-galactoside	101-152	galactosidase beta 1	Homo sapiens	71-89
6704415-3	1984	Digestion of these 3H-labeled glycopeptides with endo-beta-galactosidase resulted in the release of smaller size saccharides, which were characterized as having the structure sialic acid----Gal----GlcNAc----Gal.	Tritium	19-21	galactosidase beta 1	Homo sapiens	54-72
6704415-3	1984	Digestion of these 3H-labeled glycopeptides with endo-beta-galactosidase resulted in the release of smaller size saccharides, which were characterized as having the structure sialic acid----Gal----GlcNAc----Gal.	sialic acid----gal----glcnac	175-203	galactosidase beta 1	Homo sapiens	54-72
6704415-3	1984	Digestion of these 3H-labeled glycopeptides with endo-beta-galactosidase resulted in the release of smaller size saccharides, which were characterized as having the structure sialic acid----Gal----GlcNAc----Gal.	cyclohexenoesculetin-beta-galactoside	190-193	galactosidase beta 1	Homo sapiens	54-72
6704415-8	1984	These high molecular weight 3H-labeled glycopeptides were degraded with endo-beta-galactosidase but not with testicular hyaluronidase.	Tritium	28-30	galactosidase beta 1	Homo sapiens	77-95
6704415-8	1984	These high molecular weight 3H-labeled glycopeptides were degraded with endo-beta-galactosidase but not with testicular hyaluronidase.	Glycopeptides	39-52	galactosidase beta 1	Homo sapiens	77-95
6206870-3	1984	Lithium bromide inactivated both beta-galactosidase and beta-amylase.	lithium bromide	0-15	galactosidase beta 1	Homo sapiens	33-51
6206870-6	1984	Both enzymes were stable in rubidium chloride gradients, while potassium bromide inactivated beta-galactosidase, even in the presence of 10 mM 2-mercaptoethanol.	potassium bromide	63-80	galactosidase beta 1	Homo sapiens	93-111
6424097-1	1984	The effects of the following pyrimidine nucleoside 5"-triphosphates: f5 UTP, br5 UTP, rTTP, s2 UTP, s4 UTP and s2 CTP on cell-free expression of the beta-galactosidase gene in lambda h80dlac DNA as well as the galactokinase gene in plasmid 01-14 were investigated.	pyrimidine nucleoside 5"-triphosphates	29-67	galactosidase beta 1	Homo sapiens	149-167
6424097-1	1984	The effects of the following pyrimidine nucleoside 5"-triphosphates: f5 UTP, br5 UTP, rTTP, s2 UTP, s4 UTP and s2 CTP on cell-free expression of the beta-galactosidase gene in lambda h80dlac DNA as well as the galactokinase gene in plasmid 01-14 were investigated.	rttp	86-90	galactosidase beta 1	Homo sapiens	149-167
6202333-1	1984	Described is a novel method of fabrication of crystallized carbohydrate spheres with entrapped substances where it is shown that entrapped peptide hormones such as insulin and interferon, enzymes such as plasmin and beta-galactosidase and monoclonal antibodies retain their biological activity after release from the matrix.	Carbohydrates	59-71	galactosidase beta 1	Homo sapiens	216-234
6422434-6	1984	Treatment of beta-gal-/neur- fibroblasts with leupeptin or EP475, two inhibitors of lysosomal thiol-proteases, partially restored beta-galactosidase activity but caused no significant improvement in neuraminidase levels.	leupeptin	46-55	galactosidase beta 1	Homo sapiens	130-148
6422434-2	1984	As observed with neuraminidase activity, beta-galactosidase also showed complementation with an increase in activity when beta-gal-/neur- fibroblasts were fused with an ML II or a GMI gangliosidosis cell line.	misonidazole-glutathione conjugate	180-183	galactosidase beta 1	Homo sapiens	41-59
6422434-7	1984	The partial corrective effect of leupeptin on beta-galactosidase activity persisted for at least 2 d after removal of the drug, even in the presence of cycloheximide.	leupeptin	33-42	galactosidase beta 1	Homo sapiens	46-64
6422455-0	1984	[Method of determining the activity of beta-galactosidase with lactose as substrate].	Lactose	63-70	galactosidase beta 1	Homo sapiens	39-57
6704377-7	1984	However, chemotactic activity is only minimally reduced subsequent to hydrolysis by both neuraminidase and beta-galactosidase, indicating that receptor recognition and stimulated cell movement are mainly a function of structure of the cyanogen bromide derived fragment rather than of asparagine-linked carbohydrates.	Cyanogen Bromide	235-251	galactosidase beta 1	Homo sapiens	107-125
6704377-7	1984	However, chemotactic activity is only minimally reduced subsequent to hydrolysis by both neuraminidase and beta-galactosidase, indicating that receptor recognition and stimulated cell movement are mainly a function of structure of the cyanogen bromide derived fragment rather than of asparagine-linked carbohydrates.	Carbohydrates	302-315	galactosidase beta 1	Homo sapiens	107-125
6421574-2	1984	In the first step, the cells were incubated with endo-beta-galactosidase to selectively expose terminal N-acetylglucosamine residues of the lactosamine backbone to the chains.	Acetylglucosamine	104-123	galactosidase beta 1	Homo sapiens	54-72
6421574-2	1984	In the first step, the cells were incubated with endo-beta-galactosidase to selectively expose terminal N-acetylglucosamine residues of the lactosamine backbone to the chains.	lactosamine	140-151	galactosidase beta 1	Homo sapiens	54-72
6439694-1	1984	A quantitative cytochemical method for the measurement of beta-galactosidase activity in cultured human skin fibroblasts has been developed using 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside as the indigogenic substrate.	5-bromo-4-chloro-3-indolyl beta-galactoside	146-197	galactosidase beta 1	Homo sapiens	58-76
6439694-6	1984	The presence of sodium chloride activated beta-galactosidase up to 100 mM, but was inhibitory above that concentration.	Sodium Chloride	16-31	galactosidase beta 1	Homo sapiens	42-60
30925647-6	1984	Beta-galactosidase was added and whey was held at 5 C for 18 h to hydrolyze the lactose.	Lactose	80-87	galactosidase beta 1	Homo sapiens	0-18
6538436-5	1984	HEMPAS glycan was characterized by micelle formation, a monomer molecular weight of 4000, susceptibility to endo-beta-galactosidase and resistance to protease.	Polysaccharides	7-13	galactosidase beta 1	Homo sapiens	113-131
6422455-1	1984	A method for estimating beta-galactosidase activity (beta-D-galactosidase-galactohydrolase, EC 3.2.1.23) with lactose as substrate was developed.	Lactose	110-117	galactosidase beta 1	Homo sapiens	24-42
6414834-3	1983	E-64, a specific inhibitor of thiol proteases, prolonged 3-fold a half life of the exogenous beta-galactosidase and when the enzyme was supplied as liposomes, the half life was prolonged 9-fold in these cells.	E 64	0-4	galactosidase beta 1	Homo sapiens	93-111
6415049-3	1983	The mechanism of protection of lysosomal beta-galactosidase against proteolytic degradation is elucidated by sucrose density gradient centrifugation and immunoprecipitation studies.	Sucrose	109-116	galactosidase beta 1	Homo sapiens	41-59
6417139-3	1983	A simple and rapid purification scheme for the hybrid beta-galactosidase is described, involving ammonium sulfate fractionation, DEAE-Bio-Gel, and Bio-Gel A-1.5 chromatography.	Ammonium Sulfate	97-113	galactosidase beta 1	Homo sapiens	54-72
6417139-3	1983	A simple and rapid purification scheme for the hybrid beta-galactosidase is described, involving ammonium sulfate fractionation, DEAE-Bio-Gel, and Bio-Gel A-1.5 chromatography.	2-diethylaminoethanol	129-133	galactosidase beta 1	Homo sapiens	54-72
6417139-8	1983	The nature of the new sequence apparently has no influence on stability or activity of the hybrid, but those hybrids with more of the beta-galactosidase sequence deleted are less stable to heat or urea treatment and tend to dissociate to dimeric form.	Urea	197-201	galactosidase beta 1	Homo sapiens	134-152
6310564-5	1983	The fused preproinsulin-beta-galactosidase was further characterized by gel electrophoresis of nondenatured cell extracts stained by a fluorogenic substrate and by immunoprecipitation and gel electrophoresis of 3H-labeled cell proteins.	Tritium	211-213	galactosidase beta 1	Homo sapiens	24-42
6141130-5	1983	The activator also bound to galactosylceramide and GM2 ganglioside but scarcely to GM1 ganglioside, and activated to some extent beta-N-acetyl-hexosaminidase A and beta-galactosidase, although the CSase activator could be clearly distinguished from the GM1 beta-galactosidase activator so far known.	Galactosylceramides	28-46	galactosidase beta 1	Homo sapiens	257-275
6414473-1	1983	Human Tamm-Horsfall urinary glycoprotein from an individual of the blood group Sd(a+) phenotype was tritium-labelled by treatment with galactose oxidase and sodium boro[3H]hydride and was then digested with endo-beta-galactosidase.	Tritium	100-107	galactosidase beta 1	Homo sapiens	212-230
6310564-7	1983	The expression of preproinsulin-beta-galactosidase activity was measured in the presence of high glucose, insulin, dexamethasone, or epidermal growth factor but no regulatory changes were observed.	Glucose	97-104	galactosidase beta 1	Homo sapiens	32-50
6415880-1	1983	It is shown that segmented polyurethanes with D-lactose and D-maltose residues in the main polymer chain are subjected to a specific effect of enzymes: beta-galactosidase and alpha-amylase, respectively.	Polyurethanes	27-40	galactosidase beta 1	Homo sapiens	152-170
6310564-7	1983	The expression of preproinsulin-beta-galactosidase activity was measured in the presence of high glucose, insulin, dexamethasone, or epidermal growth factor but no regulatory changes were observed.	Dexamethasone	115-128	galactosidase beta 1	Homo sapiens	32-50
6415880-1	1983	It is shown that segmented polyurethanes with D-lactose and D-maltose residues in the main polymer chain are subjected to a specific effect of enzymes: beta-galactosidase and alpha-amylase, respectively.	Lactose	46-55	galactosidase beta 1	Homo sapiens	152-170
6357071-6	1983	Unbound FDR is hydrolyzed by beta-galactosidase to release a fluorescent product that is proportional to the dibekacin concentration in the sample.	Dibekacin	109-118	galactosidase beta 1	Homo sapiens	29-47
6415880-1	1983	It is shown that segmented polyurethanes with D-lactose and D-maltose residues in the main polymer chain are subjected to a specific effect of enzymes: beta-galactosidase and alpha-amylase, respectively.	Maltose	60-69	galactosidase beta 1	Homo sapiens	152-170
6415880-1	1983	It is shown that segmented polyurethanes with D-lactose and D-maltose residues in the main polymer chain are subjected to a specific effect of enzymes: beta-galactosidase and alpha-amylase, respectively.	Polymers	91-98	galactosidase beta 1	Homo sapiens	152-170
18551445-2	1983	This produces, however, a high concentration of galactose, which is inhibitory for the enzyme catalyst (beta-galactosidase).	Galactose	48-57	galactosidase beta 1	Homo sapiens	104-122
6408079-11	1983	Golgi mannosidase II had no action on the hybrid oligosaccharide, and little action on asialo hybrid, but both were converted to the mannosidase II substrate, GlcNAcMan5GlcNAc, by appropriate treatment with neuraminidase and beta-galactosidase.	glcnacman5glcnac	159-175	galactosidase beta 1	Homo sapiens	225-243
6411075-4	1983	The addition of 2-deoxyglucose to incubation media, however, strongly inhibited both zymosan- and methylamine-stimulated beta-galactosidase secretion.	Deoxyglucose	16-30	galactosidase beta 1	Homo sapiens	121-139
6411075-4	1983	The addition of 2-deoxyglucose to incubation media, however, strongly inhibited both zymosan- and methylamine-stimulated beta-galactosidase secretion.	Zymosan	85-92	galactosidase beta 1	Homo sapiens	121-139
6411075-4	1983	The addition of 2-deoxyglucose to incubation media, however, strongly inhibited both zymosan- and methylamine-stimulated beta-galactosidase secretion.	methylamine	98-109	galactosidase beta 1	Homo sapiens	121-139
6134282-5	1983	When 150 micrograms of purified activator protein for GM1 ganglioside beta-galactosidase and sulfatide sulfatase was added in 4 ml of medium with the 14C-labeled sulfatide, correction of the sulfatide metabolism to the normal range was found.	G(M1) Ganglioside	54-57	galactosidase beta 1	Homo sapiens	70-88
6601805-3	1983	Release of penultimate galactose by beta-galactosidase or modification by galactose oxidase results in loss of the largest molecular weight multimers and increased numbers of intermediate and smaller multimers.	Galactose	23-32	galactosidase beta 1	Homo sapiens	36-54
6304737-3	1983	The cDNA sequences were inserted into the beta-galactosidase gene of an ampicillin-resistant derivative of the temperature-sensitive lysogenic bacteriophage lambda gt11.	Ampicillin	72-82	galactosidase beta 1	Homo sapiens	42-60
6311045-2	1983	The liberated lactose is hydrolyzed with beta-galactosidase, and the released galactose is oxidized with galactose dehydrogenase and NAD+; finally, the NADH produced is measured by fluorometry (excitation at 340 nm and analysis of emitted light at 465 nm).	Lactose	14-21	galactosidase beta 1	Homo sapiens	41-59
6311045-2	1983	The liberated lactose is hydrolyzed with beta-galactosidase, and the released galactose is oxidized with galactose dehydrogenase and NAD+; finally, the NADH produced is measured by fluorometry (excitation at 340 nm and analysis of emitted light at 465 nm).	NAD	152-156	galactosidase beta 1	Homo sapiens	41-59
6342533-1	1983	Verification of membrane filter total coliform colonies from drinking water was increased 87% by testing for the presence of beta-galactosidase and cytochrome oxidase, compared with verification by determination of gas production in lauryl tryptose broth.	Water	70-75	galactosidase beta 1	Homo sapiens	125-143
6407530-1	1983	An immunoassay for thromboxane B2 was developed in which the hapten molecule was labeled with beta-galactosidase.	Thromboxane B2	19-33	galactosidase beta 1	Homo sapiens	94-112
6402368-5	1983	Chronic lymphocytic leukemia cell contained lesser amounts of three other gangliosides of the neolacto or lacto series as determined by endo-beta-galactosidase treatment.	Gangliosides	74-86	galactosidase beta 1	Homo sapiens	141-159
6407530-2	1983	The immunoprecipitate formed after competition between enzyme-labeled and unlabeled thromboxane B2 was subjected to a fluorometric assay of beta-galactosidase.	Thromboxane B2	84-98	galactosidase beta 1	Homo sapiens	140-158
6816855-2	1982	Increased sensitivity was achieved by using 4-methyl-umbelliferyl-beta-D-galactopyranoside as the substrate for beta-galactosidase coupled to the purified antiferritin antibody.	4-methylumbelliferyl-galactopyranoside	44-90	galactosidase beta 1	Homo sapiens	112-130
6416742-0	1983	A beta-galactosidase isoenzyme from Turbo cornutus with substrate specificity toward GM1-ganglioside and glycoproteins.	G(M1) Ganglioside	85-100	galactosidase beta 1	Homo sapiens	2-20
6416742-7	1983	The optimal conditions for the hydrolysis of the terminal galactose from GM1-ganglioside which does not occur in gastropods, such as T. cornutus, was found to require 40 mM NaCl and 1 mM sodium taurodeoxycholate at pH 3.0 in 50 mM sodium citrate buffer, conditions similar to those by mammalian beta-galactosidase.	Galactose	58-67	galactosidase beta 1	Homo sapiens	295-313
6416742-7	1983	The optimal conditions for the hydrolysis of the terminal galactose from GM1-ganglioside which does not occur in gastropods, such as T. cornutus, was found to require 40 mM NaCl and 1 mM sodium taurodeoxycholate at pH 3.0 in 50 mM sodium citrate buffer, conditions similar to those by mammalian beta-galactosidase.	G(M1) Ganglioside	73-88	galactosidase beta 1	Homo sapiens	295-313
6416742-7	1983	The optimal conditions for the hydrolysis of the terminal galactose from GM1-ganglioside which does not occur in gastropods, such as T. cornutus, was found to require 40 mM NaCl and 1 mM sodium taurodeoxycholate at pH 3.0 in 50 mM sodium citrate buffer, conditions similar to those by mammalian beta-galactosidase.	Sodium Chloride	173-177	galactosidase beta 1	Homo sapiens	295-313
6416742-7	1983	The optimal conditions for the hydrolysis of the terminal galactose from GM1-ganglioside which does not occur in gastropods, such as T. cornutus, was found to require 40 mM NaCl and 1 mM sodium taurodeoxycholate at pH 3.0 in 50 mM sodium citrate buffer, conditions similar to those by mammalian beta-galactosidase.	Taurodeoxycholic Acid	187-211	galactosidase beta 1	Homo sapiens	295-313
6819368-5	1982	However, the mean values of urinary beta-galactosidase in the control and acute MI groups were 158.68 and 333.3 nmol/mg creatinine/hr, respectively (p less than 0.046).	Creatinine	120-130	galactosidase beta 1	Homo sapiens	36-54
6433925-1	1983	beta-Galactosidase was normalized by a serine-thiol protease inhibitor, leupeptin with concentration of 10 micrograms/ml in cultured skin fibroblasts from patients with beta-galactosidase-alpha-neuraminidase deficiency (beta-Gal-/Neu-).	leupeptin	72-81	galactosidase beta 1	Homo sapiens	0-18
7151275-1	1982	Cerebroside-beta-galactosidase (galactosylceramidase EC 3.2.1.4.6) activity was studied using galactosylceramides of uniform fatty acid composition.	Cerebrosides	0-11	galactosidase beta 1	Homo sapiens	12-30
7151275-1	1982	Cerebroside-beta-galactosidase (galactosylceramidase EC 3.2.1.4.6) activity was studied using galactosylceramides of uniform fatty acid composition.	Galactosylceramides	94-113	galactosidase beta 1	Homo sapiens	12-30
7151275-1	1982	Cerebroside-beta-galactosidase (galactosylceramidase EC 3.2.1.4.6) activity was studied using galactosylceramides of uniform fatty acid composition.	uniform fatty acid	117-135	galactosidase beta 1	Homo sapiens	12-30
7151275-4	1982	In two methods the C 24: 1 cerebroside was used as substrate in the assay of the cerebroside-beta-galactosidase activity in leukocytes from 12 Krabbe patients, 14 parents and 22 controls.	Cerebrosides	27-38	galactosidase beta 1	Homo sapiens	93-111
6816855-3	1982	Further enhancement of the specific antigen-antibody reaction was attained by the addition of 4% polyethylene glycol 6000 to the antiferritin-beta-galactosidase conjugate.	Polyethylene Glycol 6000	97-121	galactosidase beta 1	Homo sapiens	142-160
6811267-4	1982	On the basis of methylation analysis and susceptibility towards beta-galactosidase the reaction product has been identified as neolactotetraosylceramide.	paragloboside	127-152	galactosidase beta 1	Homo sapiens	64-82
6812049-5	1982	The excessive intralysosomal degradation that is responsible for the deficiency of mature beta-galactosidase can be partially corrected by addition of the protease inhibitor leupeptin, which results in the accumulation of 85,000-dalton precursor beta-galactosidase and of a partially processed 66,000-dalton form.	leupeptin	174-183	galactosidase beta 1	Homo sapiens	90-108
6812049-5	1982	The excessive intralysosomal degradation that is responsible for the deficiency of mature beta-galactosidase can be partially corrected by addition of the protease inhibitor leupeptin, which results in the accumulation of 85,000-dalton precursor beta-galactosidase and of a partially processed 66,000-dalton form.	leupeptin	174-183	galactosidase beta 1	Homo sapiens	246-264
6812049-6	1982	When mutant cells were grown in the presence of a "corrective factor" purified from the medium of NH4Cl-stimulated cell cultures, both beta-galactosidase and neuraminidase activities were restored to low control levels.	Ammonium Chloride	98-103	galactosidase beta 1	Homo sapiens	135-153
7044615-2	1982	The method involves labeling the two with separate enzymes (beta-galactosidase and alkaline phosphatase, respectively), whose catalyzed reactions can easily be distinguished from each other by absorption spectrophotometry, with o-nitrophenyl-beta-galactoside and phenolphthalein monophosphate as substrates.	2-nitrophenylgalactoside	228-258	galactosidase beta 1	Homo sapiens	60-78
7044615-2	1982	The method involves labeling the two with separate enzymes (beta-galactosidase and alkaline phosphatase, respectively), whose catalyzed reactions can easily be distinguished from each other by absorption spectrophotometry, with o-nitrophenyl-beta-galactoside and phenolphthalein monophosphate as substrates.	phenolphthalein monophosphate	263-292	galactosidase beta 1	Homo sapiens	60-78
6814483-0	1982	Inactivation of beta-Galactosidase by iodination of tyrosine-253.	Tyrosine	52-60	galactosidase beta 1	Homo sapiens	16-34
6814483-1	1982	Beta-Galactosidase is rapidly inactivated by iodination catalyzed by lactoperoxidase but is not inactivated in the presence of the substrate analogue, isopropyl beta-D-thiogalactoside (IPTG).	Isopropyl Thiogalactoside	185-189	galactosidase beta 1	Homo sapiens	0-18
6814483-6	1982	Thus, Tyr-253 is the most reactive tyrosine in beta-galactosidase.	Tyrosine	6-9	galactosidase beta 1	Homo sapiens	47-65
6814483-6	1982	Thus, Tyr-253 is the most reactive tyrosine in beta-galactosidase.	Tyrosine	35-43	galactosidase beta 1	Homo sapiens	47-65
6890381-8	1982	Both the intact transporter and transporter that had been partially depleted of carbohydrate by treatment with endo-beta-galactosidase were found to migrate anomalously upon sodium dodecyl sulfate--polyacrylamide gel electrophoresis, relative to the behavior of standard proteins.	Carbohydrates	80-92	galactosidase beta 1	Homo sapiens	116-134
6890381-8	1982	Both the intact transporter and transporter that had been partially depleted of carbohydrate by treatment with endo-beta-galactosidase were found to migrate anomalously upon sodium dodecyl sulfate--polyacrylamide gel electrophoresis, relative to the behavior of standard proteins.	Sodium Dodecyl Sulfate	174-196	galactosidase beta 1	Homo sapiens	116-134
6890381-8	1982	Both the intact transporter and transporter that had been partially depleted of carbohydrate by treatment with endo-beta-galactosidase were found to migrate anomalously upon sodium dodecyl sulfate--polyacrylamide gel electrophoresis, relative to the behavior of standard proteins.	polyacrylamide	198-212	galactosidase beta 1	Homo sapiens	116-134
6811570-1	1982	1) Two forms of acid beta-galactosidase [EC 3.1.23] with different molecular weights catalyzing the hydrolysis of GM1-ganglioside and p-nitrophenyl-beta-D-galactoside were separated and purified from porcine spleen.	G(M1) Ganglioside	114-129	galactosidase beta 1	Homo sapiens	21-39
6284772-1	1982	Surface carbohydrates of Friend erythroleukemic-cells were modified by treatment with the exoglycosidases, alpha-galactosidase, beta-galactosidase, and neuraminidase without affecting cell growth and viability either in the presence of absence of 1.8% DMSO as inducer.	Carbohydrates	8-21	galactosidase beta 1	Homo sapiens	128-146
6811570-1	1982	1) Two forms of acid beta-galactosidase [EC 3.1.23] with different molecular weights catalyzing the hydrolysis of GM1-ganglioside and p-nitrophenyl-beta-D-galactoside were separated and purified from porcine spleen.	4-nitrophenylgalactoside	134-166	galactosidase beta 1	Homo sapiens	21-39
6804462-11	1982	When acid and beta-galactosidase-treated human tracheobronchial mucin was used as the acceptor, 3.3% of the product was found as [14C]Gal-GalNAc-H2.	Carbon-14	130-133	galactosidase beta 1	Homo sapiens	14-32
6979604-4	1982	We determined, therefore, the absolute frequency of LPS- and NDCM-sensitive B lymphocytes secreting immunoglobulin molecules that bear three idiotopes originally found on a monoclonal anti-beta galactosidase antibody.	Nocardia delipidated cell mitogen	61-65	galactosidase beta 1	Homo sapiens	189-207
6277894-9	1982	beta-Galactosidase from Aspergillus niger selectively cleaved the Gal beta 1-4GlcNAc linkage in the intact tetrasaccharide.	tetrasaccharide	107-122	galactosidase beta 1	Homo sapiens	0-18
6807347-5	1982	Addition of 0.1 M galactose caused at pH 3.5, but not at pH 4.0 and 7.0, an increased formation of multimeric beta-galactosidase which eluted with the void volume of the column.	Galactose	18-27	galactosidase beta 1	Homo sapiens	110-128
6807347-12	1982	The affinity of beta-galactosidase for [3H]keratan sulfate and the 3H-labelled pentasaccharide was at least one order of magnitude lower than for the amphiphilic substrates.	[3h]keratan sulfate	39-58	galactosidase beta 1	Homo sapiens	16-34
6807347-12	1982	The affinity of beta-galactosidase for [3H]keratan sulfate and the 3H-labelled pentasaccharide was at least one order of magnitude lower than for the amphiphilic substrates.	Tritium	40-42	galactosidase beta 1	Homo sapiens	16-34
6807347-12	1982	The affinity of beta-galactosidase for [3H]keratan sulfate and the 3H-labelled pentasaccharide was at least one order of magnitude lower than for the amphiphilic substrates.	pentasaccharide	79-94	galactosidase beta 1	Homo sapiens	16-34
6810568-3	1982	The quantitative amounts of beta-galactosidase produced in each clone were estimated by assaying enzyme activity and by measuring the specific beta-galactosidase protein following fractionation of total cells" proteins on polyacrylamide gel.	polyacrylamide	222-236	galactosidase beta 1	Homo sapiens	28-46
6212169-2	1982	This substrate was prepared from a cornea keratan sulfate by digestion with endo-beta-galactosidase, followed by isolation of disaccharide on gel filtration chromatography and chemical desulfation.	Keratan Sulfate	42-57	galactosidase beta 1	Homo sapiens	81-99
6811372-6	1982	The beta-galactosidase present in the bands used for Glb-1 typing resembles human GM1 gangliosidase (GLB1) with respect to pH optimum, substrate specificity, and susceptibility to inhibition by PMB.	4-mercuribenzoate	194-197	galactosidase beta 1	Homo sapiens	4-22
6811372-6	1982	The beta-galactosidase present in the bands used for Glb-1 typing resembles human GM1 gangliosidase (GLB1) with respect to pH optimum, substrate specificity, and susceptibility to inhibition by PMB.	4-mercuribenzoate	194-197	galactosidase beta 1	Homo sapiens	53-58
6811372-6	1982	The beta-galactosidase present in the bands used for Glb-1 typing resembles human GM1 gangliosidase (GLB1) with respect to pH optimum, substrate specificity, and susceptibility to inhibition by PMB.	4-mercuribenzoate	194-197	galactosidase beta 1	Homo sapiens	101-105
6807295-2	1982	(1) The release of beta-galactosidase from macrophages exposed to methylamine and chloroquine was found to be highly dependent on the pH of the incubation medium; the degree of lysosomal secretion correlated closely with the amount of free base in solution at each pH investigated.	methylamine	66-77	galactosidase beta 1	Homo sapiens	19-37
6807295-2	1982	(1) The release of beta-galactosidase from macrophages exposed to methylamine and chloroquine was found to be highly dependent on the pH of the incubation medium; the degree of lysosomal secretion correlated closely with the amount of free base in solution at each pH investigated.	Chloroquine	82-93	galactosidase beta 1	Homo sapiens	19-37
6807295-3	1982	(2) The secretion of beta-galactosidase induced by methylamine was additively enhanced by a fixed dose of zymosan; likewise, chloroquine additively enhanced the secretion of beta-galactosidase during exposure to zymosan.	methylamine	51-62	galactosidase beta 1	Homo sapiens	21-39
6807295-3	1982	(2) The secretion of beta-galactosidase induced by methylamine was additively enhanced by a fixed dose of zymosan; likewise, chloroquine additively enhanced the secretion of beta-galactosidase during exposure to zymosan.	methylamine	51-62	galactosidase beta 1	Homo sapiens	174-192
6807295-3	1982	(2) The secretion of beta-galactosidase induced by methylamine was additively enhanced by a fixed dose of zymosan; likewise, chloroquine additively enhanced the secretion of beta-galactosidase during exposure to zymosan.	Zymosan	106-113	galactosidase beta 1	Homo sapiens	21-39
6807295-3	1982	(2) The secretion of beta-galactosidase induced by methylamine was additively enhanced by a fixed dose of zymosan; likewise, chloroquine additively enhanced the secretion of beta-galactosidase during exposure to zymosan.	Chloroquine	125-136	galactosidase beta 1	Homo sapiens	21-39
6807295-3	1982	(2) The secretion of beta-galactosidase induced by methylamine was additively enhanced by a fixed dose of zymosan; likewise, chloroquine additively enhanced the secretion of beta-galactosidase during exposure to zymosan.	Chloroquine	125-136	galactosidase beta 1	Homo sapiens	174-192
6807295-3	1982	(2) The secretion of beta-galactosidase induced by methylamine was additively enhanced by a fixed dose of zymosan; likewise, chloroquine additively enhanced the secretion of beta-galactosidase during exposure to zymosan.	Zymosan	212-219	galactosidase beta 1	Homo sapiens	21-39
6807295-3	1982	(2) The secretion of beta-galactosidase induced by methylamine was additively enhanced by a fixed dose of zymosan; likewise, chloroquine additively enhanced the secretion of beta-galactosidase during exposure to zymosan.	Zymosan	212-219	galactosidase beta 1	Homo sapiens	174-192
7053380-9	1982	In addition, a specific limited enzyme digestion of Ad-glycolipid was made by incorporating the glycolipid into liposomes before endo-beta-galactosidase digestion.	ad-glycolipid	52-65	galactosidase beta 1	Homo sapiens	134-152
6280513-0	1982	Beta-Galactosidase immunoassay for the measurement of cyclic AMP.	Cyclic AMP	54-64	galactosidase beta 1	Homo sapiens	0-18
7053380-9	1982	In addition, a specific limited enzyme digestion of Ad-glycolipid was made by incorporating the glycolipid into liposomes before endo-beta-galactosidase digestion.	Glycolipids	55-65	galactosidase beta 1	Homo sapiens	134-152
6189376-1	1982	Alkaline phosphate, catalase and beta-galactosidase activities of Vibrio et tor were decreased after acquisition of resistance towards rifampicin.	Rifampin	135-145	galactosidase beta 1	Homo sapiens	33-51
6807121-4	1982	However, the amount of the brain GM1-ganglioside was accumulated to a less degree in comparison with that of typical type 2 GM1-gangliosidosis, though the activity of GM1-beta-galactosidase in the brain was deficient to the same degree as in the typical case.	G(M1) Ganglioside	33-48	galactosidase beta 1	Homo sapiens	171-189
24234084-0	1982	Enzymes coimmobilized with microorganisms : The bioconversion of whey permeate to ethanol with Beta-galactosidase andSaccharomyces cerevisiae.	Ethanol	82-89	galactosidase beta 1	Homo sapiens	95-113
24234084-1	1982	The enzyme Beta-galactosidase was coimmobilized with the yeastSaccharomyces cerevisiae in alginate.	Alginates	90-98	galactosidase beta 1	Homo sapiens	11-29
6269648-3	1981	On a 4.6% gel (acrylamide:bisacrylamide, 20:1), the material migrated as a diffuse band to a position between those of beta-galactosidase (Mr 130 000) and myosin (Mr 200 000).	N,N'-methylenebisacrylamide	26-39	galactosidase beta 1	Homo sapiens	119-137
7044895-2	1981	The gene, composed of oligonucleotide fragments synthesized by the triester method, was cloned and expressed as a beta-galactosidase hybrid protein.	Oligonucleotides	22-37	galactosidase beta 1	Homo sapiens	114-132
6947231-4	1981	The quantity and structure of the carbohydrate chains susceptible to endo-beta-galactosidase ("lactosaminoglycan") are also significantly different among cell lines.	Carbohydrates	34-46	galactosidase beta 1	Homo sapiens	74-92
6790542-4	1981	All these 95 oligosaccharides contain Gal beta 1 leads to 4GlcNAc beta 1 lead to 3 repeating structures in their outer chain moieties, indicating that the tissues of GM1-gangliosidosis Type 2 patients do contain beta-galactosidase activity which releases readily galactose residue from such repeating sugar chains.	Oligosaccharides	13-29	galactosidase beta 1	Homo sapiens	212-230
6790542-4	1981	All these 95 oligosaccharides contain Gal beta 1 leads to 4GlcNAc beta 1 lead to 3 repeating structures in their outer chain moieties, indicating that the tissues of GM1-gangliosidosis Type 2 patients do contain beta-galactosidase activity which releases readily galactose residue from such repeating sugar chains.	Galactose	263-272	galactosidase beta 1	Homo sapiens	212-230
6790542-4	1981	All these 95 oligosaccharides contain Gal beta 1 leads to 4GlcNAc beta 1 lead to 3 repeating structures in their outer chain moieties, indicating that the tissues of GM1-gangliosidosis Type 2 patients do contain beta-galactosidase activity which releases readily galactose residue from such repeating sugar chains.	Sugars	301-306	galactosidase beta 1	Homo sapiens	212-230
6800355-2	1981	beta-Galactosidase was specifically inactivated with the suicide substrate beta-D-galactopyranosylmethyl-p-nitro-phenyltriazene (beta-Gal-MNT) and from the subsequent restoration of enzyme activity in cell cultures turnover times were calculated.	beta-D-galactopyranosylmethyl-4-nitrophenyltriazene	75-127	galactosidase beta 1	Homo sapiens	0-18
6800355-3	1981	By using [3H]beta-Gal-MNT, the hydrolytic activity per molecule of beta-galactosidase was determined.	Tritium	10-12	galactosidase beta 1	Homo sapiens	67-85
6796568-0	1981	beta-Galactosidase-linked immunoassay of prostaglandin F2 alpha.	Dinoprost	41-63	galactosidase beta 1	Homo sapiens	0-18
6269648-3	1981	On a 4.6% gel (acrylamide:bisacrylamide, 20:1), the material migrated as a diffuse band to a position between those of beta-galactosidase (Mr 130 000) and myosin (Mr 200 000).	Acrylamide	15-25	galactosidase beta 1	Homo sapiens	119-137
6793566-1	1981	Beta-Galactosidase was partially restored by protease inhibitors, leupeptin, chymostatin and E-64 in cultured fibroblasts from three patients with beta-galactosidase-neuraminidase deficiency.	leupeptin	66-75	galactosidase beta 1	Homo sapiens	0-18
6789880-4	1981	Specific cleavage of the enzymatic product by beta-galactosidase indicated a beta-configuration for incorporated galactose.	Galactose	113-122	galactosidase beta 1	Homo sapiens	46-64
6787458-3	1981	GM1 gangliosidosis was diagnosed by absence of beta-galactosidase activity in leukocytes and fibroblasts.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	47-65
7230738-5	1981	Using the analytical method of sequential enzymatic degradation, confluent cultures of corneal fibroblasts, but not cutaneous fibroblasts, were found to synthesize and secrete into the nutrient medium a small quantity of sulfate glycosaminoglycans that was susceptible to keratan sulfate endo-beta-galactosidase (Pseudomonas)--an enzyme that degrades corneal keratan sulfate to oligosaccharides of variable size and sulfation.	sulfate glycosaminoglycans	221-247	galactosidase beta 1	Homo sapiens	293-311
7230738-7	1981	Although cutaneous fibroblasts do not produce significant quantities of sulfated material with the attributes of keratan sulfate, they do incorporate 3H-glucosamine into macromolecules that are susceptible to keratan sulfate endo-beta-galactosidase.	beta-D-Glucosamine	150-164	galactosidase beta 1	Homo sapiens	230-248
7237832-4	1981	The highest specific cerebroside-beta-galactosidase activities were obtained with N-palmitoyl galactosyl- and lactosylceramides.	n-palmitoyl galactosyl- and lactosylceramides	82-127	galactosidase beta 1	Homo sapiens	33-51
6791575-4	1981	In brain and liver, the 4-methylumbelliferyl beta-galactosidase with acidic pH optimum and lactosylceramidase II were deficient while other hydrolases were present in normal amounts, including sialidase determined with N-acetylneuramin-lactose and fetuin as substrates.	N-acetylneuraminoyllactose	219-243	galactosidase beta 1	Homo sapiens	45-63
6788082-2	1981	Oxygen-18 leaving group kinetic isotope effects (KIEs) have been determined on both Vmax (V) and Vmax/Km (V/K) for the beta-galactosidase-catalyzed hydrolysis of p-nitrophenyl beta-D-galactoside (I) and 2,4-dinitrophenyl beta-D-galactoside (II).	Oxygen	0-6	galactosidase beta 1	Homo sapiens	119-137
6788082-2	1981	Oxygen-18 leaving group kinetic isotope effects (KIEs) have been determined on both Vmax (V) and Vmax/Km (V/K) for the beta-galactosidase-catalyzed hydrolysis of p-nitrophenyl beta-D-galactoside (I) and 2,4-dinitrophenyl beta-D-galactoside (II).	4-nitrophenylgalactoside	162-194	galactosidase beta 1	Homo sapiens	119-137
6788082-2	1981	Oxygen-18 leaving group kinetic isotope effects (KIEs) have been determined on both Vmax (V) and Vmax/Km (V/K) for the beta-galactosidase-catalyzed hydrolysis of p-nitrophenyl beta-D-galactoside (I) and 2,4-dinitrophenyl beta-D-galactoside (II).	2',4'-Dinitrophenyl-beta-galactopyranoside	203-239	galactosidase beta 1	Homo sapiens	119-137
7237832-7	1981	With galactosylceramides as substrates the residual cerebroside-beta-galactosidase activity was 7%, with lactosylceramides 8%, and there was no overlap in enzyme activity between the 45 patients and 42 parents.	Galactosylceramides	5-24	galactosidase beta 1	Homo sapiens	64-82
6784662-2	1981	Certain genetic and biochemical studies have suggested that the phenotypic variation found in GM1 gangliosidosis results from different allelic mutations affecting the GM1 ganglioside beta-galactosidase locus and that different combinations of these mutations accounts for the clinical heterogeneity of this illness.	G(M1) Ganglioside	94-97	galactosidase beta 1	Homo sapiens	184-202
6784662-2	1981	Certain genetic and biochemical studies have suggested that the phenotypic variation found in GM1 gangliosidosis results from different allelic mutations affecting the GM1 ganglioside beta-galactosidase locus and that different combinations of these mutations accounts for the clinical heterogeneity of this illness.	G(M1) Ganglioside	168-171	galactosidase beta 1	Homo sapiens	184-202
6784662-3	1981	A family in which both the infantile and juvenile forms of GM1 gangliosidosis occurred, the children sharing a common mutation of their acid beta-galactosidase activity, supports the allelic nature of these different clinical forms of the disease.	G(M1) Ganglioside	59-62	galactosidase beta 1	Homo sapiens	141-159
7305960-2	1981	A method is described for following continuously the action of beta-galactosidase on 4-methylumbelliferyl beta-D-galactoside at pH 4.5, in which 4-methylumbelliferone production is measured at fluorescence excitation and emission wavelengths of 324 and 444nm respectively.	4-methylumbelliferyl-galactopyranoside	85-124	galactosidase beta 1	Homo sapiens	63-81
7305960-2	1981	A method is described for following continuously the action of beta-galactosidase on 4-methylumbelliferyl beta-D-galactoside at pH 4.5, in which 4-methylumbelliferone production is measured at fluorescence excitation and emission wavelengths of 324 and 444nm respectively.	Hymecromone	145-166	galactosidase beta 1	Homo sapiens	63-81
6784663-1	1981	Acid beta-galactosidase activity can be separated into multiple molecular forms by isoelectric focusing on cellulose acetate membranes.	acetylcellulose	107-124	galactosidase beta 1	Homo sapiens	5-23
7305960-4	1981	Initial-rate studies show that the presence of salt activates beta-galactosidase up to 100 mM, but is inhibitory above that concentration.	Salts	47-51	galactosidase beta 1	Homo sapiens	62-80
6784663-2	1981	The residual acid beta-galactosidase in the juvenile form of GM1 gangliosidosis has three bands of enzyme activity with an apparent isoelectric pH (pI) range from 4.9 to 5.2, whereas that in the infantile form has a single band with an apparent pI of 5.2.	G(M1) Ganglioside	61-64	galactosidase beta 1	Homo sapiens	18-36
6784663-3	1981	Separation of residual acid beta-galactosidase into multiple molecular forms by analytical isoelectric focusing demonstrates enzymatic differences that can be correlated with the allelic mutations that affect the GM1 ganglioside beta-galactosidase locus.	G(M1) Ganglioside	213-228	galactosidase beta 1	Homo sapiens	28-46
6784663-3	1981	Separation of residual acid beta-galactosidase into multiple molecular forms by analytical isoelectric focusing demonstrates enzymatic differences that can be correlated with the allelic mutations that affect the GM1 ganglioside beta-galactosidase locus.	G(M1) Ganglioside	213-228	galactosidase beta 1	Homo sapiens	229-247
6792285-2	1981	Purified rabbit IgG anti-human IgG antibodies are conjugated to beta-galactosidase with meta-maleimidobenzoyl-hydroxysuccinimide ester as a bifunctional reagent and o-nitrophenyl-beta-galactopyranoside as a substrate to evaluate the enzymatic activity of the labeled antiglobulin.	meta-maleimidobenzoyl-hydroxysuccinimide ester	88-134	galactosidase beta 1	Homo sapiens	64-82
6787801-0	1981	[Possibility of obtaining low-lactose infant dairy products by using beta-galactosidase].	Lactose	30-37	galactosidase beta 1	Homo sapiens	69-87
7213594-10	1981	Retention by concanavalin A-Sepharose was observed only after treatment of the oligosaccharide with beta-galactosidase.	Sepharose	28-37	galactosidase beta 1	Homo sapiens	100-118
7213594-10	1981	Retention by concanavalin A-Sepharose was observed only after treatment of the oligosaccharide with beta-galactosidase.	Oligosaccharides	79-94	galactosidase beta 1	Homo sapiens	100-118
6793470-0	1981	Activity of beta-galactosidase in soil continuously supplemented with lactose.	Lactose	70-77	galactosidase beta 1	Homo sapiens	12-30
6782107-5	1981	The cell adhesion on beta-galactosidase coat was inhibited by 1,4-D-galactonolactone and beta-methylgalactoside but not by alpha-methylgalactoside.	galactonolactone	62-84	galactosidase beta 1	Homo sapiens	21-39
6782107-5	1981	The cell adhesion on beta-galactosidase coat was inhibited by 1,4-D-galactonolactone and beta-methylgalactoside but not by alpha-methylgalactoside.	beta-methylgalactoside	89-111	galactosidase beta 1	Homo sapiens	21-39
6792285-2	1981	Purified rabbit IgG anti-human IgG antibodies are conjugated to beta-galactosidase with meta-maleimidobenzoyl-hydroxysuccinimide ester as a bifunctional reagent and o-nitrophenyl-beta-galactopyranoside as a substrate to evaluate the enzymatic activity of the labeled antiglobulin.	o-nitrophenyl-beta-galactopyranoside	165-201	galactosidase beta 1	Homo sapiens	64-82
7466801-10	1980	Nevertheless, the presence of small portions of galactose and xylose residues at the reducing ends of the carbohydrate chains suggested a possibility of  exertion of endo-beta-galactosidase and endo-beta-xylosidase activities for the linkage regions.	Galactose	48-57	galactosidase beta 1	Homo sapiens	171-189
6780781-0	1980	Comparative effects of methyl- and ethylnitrosourea on DNA directing cell-free DNA-dependent synthesis of beta-galactosidase.	methyl- and ethylnitrosourea	23-51	galactosidase beta 1	Homo sapiens	106-124
6774880-1	1980	We synthesized the m-maleimidobenzoyl derivative of digoxigenin-3-0-succinate (through a p-phenylenediamine bridge) as a hapten derivative directed towards coupling to sulfhydryl grouos of beta-galactosidase.	m-maleimidobenzoyl	19-37	galactosidase beta 1	Homo sapiens	189-207
6774880-1	1980	We synthesized the m-maleimidobenzoyl derivative of digoxigenin-3-0-succinate (through a p-phenylenediamine bridge) as a hapten derivative directed towards coupling to sulfhydryl grouos of beta-galactosidase.	digoxigenin-3-0-succinate	52-77	galactosidase beta 1	Homo sapiens	189-207
6774961-1	1980	An in vitro coupled transcription-translation system was used to synthesize transaminase B and beta-galactosidase in the presence of a deoxyribonucleic acid template containing lac deoxyribonucleic acid under normal lac-specific control and in the presence of several deoxyribonucleic acid templates containing lac deoxyribonucleic acid fused to the ilvD gene.	lac deoxyribonucleic acid	177-202	galactosidase beta 1	Homo sapiens	95-113
6774961-1	1980	An in vitro coupled transcription-translation system was used to synthesize transaminase B and beta-galactosidase in the presence of a deoxyribonucleic acid template containing lac deoxyribonucleic acid under normal lac-specific control and in the presence of several deoxyribonucleic acid templates containing lac deoxyribonucleic acid fused to the ilvD gene.	lac deoxyribonucleic acid	311-336	galactosidase beta 1	Homo sapiens	95-113
6774961-7	1980	beta-Galactosidase synthesis was stimulated by guanosine 3"-pyrophosphate-5"-pyrophosphate with all templates tested except that in which the ilv-lac fusion had been inverted.	guanosine 3"-pyrophosphate-5"-pyrophosphate	47-90	galactosidase beta 1	Homo sapiens	0-18
6773584-7	1980	Since 80-90% of lactosylceramide-cleaving activity in normal fibroblasts is due to GM1-ganglioside beta-galactosidase and since fibroblasts of globoid cell leukodystrophy patients are genetically deficient in galactosylceramidase but normal in GM1-ganglioside beta-galactosidase, these rsults are also consistent with specific activation of galactosylceramidase by phosphatidylserine.	CDw17 antigen	16-32	galactosidase beta 1	Homo sapiens	99-117
6773584-7	1980	Since 80-90% of lactosylceramide-cleaving activity in normal fibroblasts is due to GM1-ganglioside beta-galactosidase and since fibroblasts of globoid cell leukodystrophy patients are genetically deficient in galactosylceramidase but normal in GM1-ganglioside beta-galactosidase, these rsults are also consistent with specific activation of galactosylceramidase by phosphatidylserine.	CDw17 antigen	16-32	galactosidase beta 1	Homo sapiens	260-278
6773584-7	1980	Since 80-90% of lactosylceramide-cleaving activity in normal fibroblasts is due to GM1-ganglioside beta-galactosidase and since fibroblasts of globoid cell leukodystrophy patients are genetically deficient in galactosylceramidase but normal in GM1-ganglioside beta-galactosidase, these rsults are also consistent with specific activation of galactosylceramidase by phosphatidylserine.	G(M1) Ganglioside	83-98	galactosidase beta 1	Homo sapiens	99-117
6795597-1	1981	A cell-free system for the expression of the beta-galactosidase gene was employed to study the effects of the UTP and CTP analogs: s2UTP, s2CTP, f5UTP and rTTP on transcription-translation.	Uridine Triphosphate	110-113	galactosidase beta 1	Homo sapiens	45-63
6795597-1	1981	A cell-free system for the expression of the beta-galactosidase gene was employed to study the effects of the UTP and CTP analogs: s2UTP, s2CTP, f5UTP and rTTP on transcription-translation.	Cytidine Triphosphate	118-121	galactosidase beta 1	Homo sapiens	45-63
6795597-2	1981	From the analogs investigated, only rTTP turned out to be able to substitute UTP in the cell-free synthesis of beta-galactosidase.	rttp	36-40	galactosidase beta 1	Homo sapiens	111-129
6795597-2	1981	From the analogs investigated, only rTTP turned out to be able to substitute UTP in the cell-free synthesis of beta-galactosidase.	Uridine Triphosphate	77-80	galactosidase beta 1	Homo sapiens	111-129
6253579-4	1980	Hydrolytic cleavage of exposed carbohydrate moieties by purified glycosidases revealed increased fluorescence after treatment of fixed cells by neuramindase, no perceptible change after N-acetylhexosaminidase treatment, but a pronounced decrease after exposure to beta-galactosidase.	Carbohydrates	31-43	galactosidase beta 1	Homo sapiens	264-282
6253579-4	1980	Hydrolytic cleavage of exposed carbohydrate moieties by purified glycosidases revealed increased fluorescence after treatment of fixed cells by neuramindase, no perceptible change after N-acetylhexosaminidase treatment, but a pronounced decrease after exposure to beta-galactosidase.	neuramindase	144-156	galactosidase beta 1	Homo sapiens	264-282
6107184-1	1980	The activation of sphingomyelinase, galactosyl- and lactosylceramide beta-galactosidases, GM1, beta-galactosidase, cerebroside sulphate sulphatase, trihexosylceramide alpha-galactosidase and globoside beta-hexosaminidase by a number of bile salts was studied.	Bile Acids and Salts	236-246	galactosidase beta 1	Homo sapiens	69-87
6774745-0	1980	Comparison of the beta-galactosidase conformations induced by D-galactal and by magnesium ions.	Magnesium	80-89	galactosidase beta 1	Homo sapiens	18-36
6774976-0	1980	pH-dependent association-dissociation of GM1-beta-galactosidase purified from porcine spleen.	G(M1) Ganglioside	41-44	galactosidase beta 1	Homo sapiens	45-63
6774976-1	1980	A beta-galactosidase [EC 3.1.23] catalyzing the hydrolysis of GM1-ganglioside was purified from porcine spleen to a homogeneous form.	G(M1) Ganglioside	62-77	galactosidase beta 1	Homo sapiens	2-20
7004339-3	1980	This beta-galactosyl-umbelliferone-amikacin conjugate is nonfluorescent under assay conditions until it is hydrolyzed by beta-galactosidase to yield a fluorescent product.	beta-galactosyl-umbelliferone	5-34	galactosidase beta 1	Homo sapiens	121-139
7004339-3	1980	This beta-galactosyl-umbelliferone-amikacin conjugate is nonfluorescent under assay conditions until it is hydrolyzed by beta-galactosidase to yield a fluorescent product.	Amikacin	35-43	galactosidase beta 1	Homo sapiens	121-139
7466801-10	1980	Nevertheless, the presence of small portions of galactose and xylose residues at the reducing ends of the carbohydrate chains suggested a possibility of  exertion of endo-beta-galactosidase and endo-beta-xylosidase activities for the linkage regions.	Xylose	62-68	galactosidase beta 1	Homo sapiens	171-189
7466801-10	1980	Nevertheless, the presence of small portions of galactose and xylose residues at the reducing ends of the carbohydrate chains suggested a possibility of  exertion of endo-beta-galactosidase and endo-beta-xylosidase activities for the linkage regions.	Carbohydrates	106-118	galactosidase beta 1	Homo sapiens	171-189
6774338-1	1980	HUMAN ERYTHROBLASTS IN CULTURE, IRRESPECTIVE OF THE ONTOGENIC STAGE OF THEIR PROGENITORS, ARE CHARACTERIZED BY: (i) the barely detectable amount of band 3 glycoprotein, (ii) the presence of two glycoproteins with molecular weights 105,000 and 95,000, (iii) the high concentration of glycophorin, and (iv) a minimum quantity of the carbohydrate chain susceptible to endo-beta-galactosidase ("polylactosaminoglycan").	Carbohydrates	331-343	galactosidase beta 1	Homo sapiens	370-388
6774338-5	1980	The profiles of oligosaccharides released by endo-beta-galactosidase and immunofluorescence studies with anti-Ii antibodies indicated that a linear polylactosaminoglycan structure was present in erythroblasts as well as in erythrocytes of the fetal and newborn stage, whereas a branched polylactosaminoglycan structure was present in erythroblasts as well as erythrocytes of adult blood.	Oligosaccharides	16-32	galactosidase beta 1	Homo sapiens	50-68
6772162-6	1980	Both beta-galactosidase and beta-glucosidase activities in triazene-treated confluent fibroblast cultures recover exponentially; if zero-order enzyme production is assumed, turnover times of 10 and 5 days respectively can be estimated.	Triazenes	59-67	galactosidase beta 1	Homo sapiens	5-23
6791848-0	1980	Inhibition of DNA-directed beta-galactosidase synthesis in a cell-free system by dimethyl sulfate and N-methyl-N-nitrosourea.	dimethyl sulfate	81-97	galactosidase beta 1	Homo sapiens	27-45
6791848-0	1980	Inhibition of DNA-directed beta-galactosidase synthesis in a cell-free system by dimethyl sulfate and N-methyl-N-nitrosourea.	Methylnitrosourea	102-124	galactosidase beta 1	Homo sapiens	27-45
6768582-1	1980	A new cortisol derivative, cortisol-21-m-maleimidobenzoate (CMB), was synthesized and conjugated with sulfhydryl groups of beta-galactosidase (BG).	Hydrocortisone	6-14	galactosidase beta 1	Homo sapiens	123-141
7188422-9	1980	Most of these oligosaccharides were digested with a mixture of beta-galactosidase and beta-N-acetylhexosaminidase after alpha-L-fucosidase treatment to give a small oligosaccharide with the structure alpha Man2-beta Man-beta GlcNAc-GlcNAc.	Oligosaccharides	14-30	galactosidase beta 1	Homo sapiens	63-81
7188422-9	1980	Most of these oligosaccharides were digested with a mixture of beta-galactosidase and beta-N-acetylhexosaminidase after alpha-L-fucosidase treatment to give a small oligosaccharide with the structure alpha Man2-beta Man-beta GlcNAc-GlcNAc.	Oligosaccharides	14-29	galactosidase beta 1	Homo sapiens	63-81
7188422-9	1980	Most of these oligosaccharides were digested with a mixture of beta-galactosidase and beta-N-acetylhexosaminidase after alpha-L-fucosidase treatment to give a small oligosaccharide with the structure alpha Man2-beta Man-beta GlcNAc-GlcNAc.	Acetylglucosamine	220-231	galactosidase beta 1	Homo sapiens	63-81
7188422-9	1980	Most of these oligosaccharides were digested with a mixture of beta-galactosidase and beta-N-acetylhexosaminidase after alpha-L-fucosidase treatment to give a small oligosaccharide with the structure alpha Man2-beta Man-beta GlcNAc-GlcNAc.	Acetylglucosamine	225-231	galactosidase beta 1	Homo sapiens	63-81
6768582-1	1980	A new cortisol derivative, cortisol-21-m-maleimidobenzoate (CMB), was synthesized and conjugated with sulfhydryl groups of beta-galactosidase (BG).	cortisol-21-3-maleimidobenzoate	27-58	galactosidase beta 1	Homo sapiens	123-141
6768582-1	1980	A new cortisol derivative, cortisol-21-m-maleimidobenzoate (CMB), was synthesized and conjugated with sulfhydryl groups of beta-galactosidase (BG).	cortisol-21-3-maleimidobenzoate	60-63	galactosidase beta 1	Homo sapiens	123-141
6767344-0	1980	The specificity of beta-galactosidase in the degradation of gangliosides.	Gangliosides	60-72	galactosidase beta 1	Homo sapiens	19-37
6446239-5	1980	Deficient beta-gal activity was observed toward p-nitrophenyl-beta-galactoside, 4-methylumbelliferyl-beta-galactoside (4 MU-beta-gal), lactose, GM1 ganglioside, keratan sulfate, and asialofetuin (ASF).	p-nitrophenyl-beta-galactoside	48-78	galactosidase beta 1	Homo sapiens	10-18
6446239-5	1980	Deficient beta-gal activity was observed toward p-nitrophenyl-beta-galactoside, 4-methylumbelliferyl-beta-galactoside (4 MU-beta-gal), lactose, GM1 ganglioside, keratan sulfate, and asialofetuin (ASF).	4-methylumbelliferyl-galactopyranoside	80-117	galactosidase beta 1	Homo sapiens	10-18
6446239-5	1980	Deficient beta-gal activity was observed toward p-nitrophenyl-beta-galactoside, 4-methylumbelliferyl-beta-galactoside (4 MU-beta-gal), lactose, GM1 ganglioside, keratan sulfate, and asialofetuin (ASF).	Lactose	135-142	galactosidase beta 1	Homo sapiens	10-18
6446239-5	1980	Deficient beta-gal activity was observed toward p-nitrophenyl-beta-galactoside, 4-methylumbelliferyl-beta-galactoside (4 MU-beta-gal), lactose, GM1 ganglioside, keratan sulfate, and asialofetuin (ASF).	G(M1) Ganglioside	144-159	galactosidase beta 1	Homo sapiens	10-18
6446239-5	1980	Deficient beta-gal activity was observed toward p-nitrophenyl-beta-galactoside, 4-methylumbelliferyl-beta-galactoside (4 MU-beta-gal), lactose, GM1 ganglioside, keratan sulfate, and asialofetuin (ASF).	Keratan Sulfate	161-176	galactosidase beta 1	Homo sapiens	10-18
6766333-1	1980	The hydrophobic interaction of beta-galactosidase with Sepharose 4B substituted with 3,3"-diaminodipropylamine was studied in both batch and column experiments.	Sepharose	55-67	galactosidase beta 1	Homo sapiens	31-49
6766333-1	1980	The hydrophobic interaction of beta-galactosidase with Sepharose 4B substituted with 3,3"-diaminodipropylamine was studied in both batch and column experiments.	3,3"-diaminodipropylamine	85-110	galactosidase beta 1	Homo sapiens	31-49
6766828-0	1980	A comparison of the properties and bile salt specificities of galactosylceramide and lactosyl ceramide beta-galactosidase activities in human leucocytes and fibroblasts.	Bile Acids and Salts	35-44	galactosidase beta 1	Homo sapiens	103-121
6766828-1	1980	The properties and bile salt specificities of galactosylceramide and lactosylceramide beta-galactosidase activities (GC and LC-beta-galactosidases) of human leucocytes and fibroblasts were compared.	Bile Acids and Salts	19-28	galactosidase beta 1	Homo sapiens	86-104
6766828-4	1980	Glycocholate and cholate were more active stimulators of the GC-beta-galactosidase than the more frequently used taurocholate which was the most effective stimulator of LC-beta-galactosidase activity.	Glycocholic Acid	0-12	galactosidase beta 1	Homo sapiens	64-82
6766828-4	1980	Glycocholate and cholate were more active stimulators of the GC-beta-galactosidase than the more frequently used taurocholate which was the most effective stimulator of LC-beta-galactosidase activity.	Glycocholic Acid	0-12	galactosidase beta 1	Homo sapiens	172-190
6766828-4	1980	Glycocholate and cholate were more active stimulators of the GC-beta-galactosidase than the more frequently used taurocholate which was the most effective stimulator of LC-beta-galactosidase activity.	Cholates	5-12	galactosidase beta 1	Homo sapiens	64-82
6766828-4	1980	Glycocholate and cholate were more active stimulators of the GC-beta-galactosidase than the more frequently used taurocholate which was the most effective stimulator of LC-beta-galactosidase activity.	Cholates	5-12	galactosidase beta 1	Homo sapiens	172-190
6766828-4	1980	Glycocholate and cholate were more active stimulators of the GC-beta-galactosidase than the more frequently used taurocholate which was the most effective stimulator of LC-beta-galactosidase activity.	Taurocholic Acid	113-125	galactosidase beta 1	Homo sapiens	172-190
6766828-7	1980	Residual LC-beta-galactosidase activity detected in these cells was much higher ranging from 13% of the lowest measured value when measured with taurocholate to approximately normal values with glycocholate.	Taurocholic Acid	145-157	galactosidase beta 1	Homo sapiens	12-30
6766828-7	1980	Residual LC-beta-galactosidase activity detected in these cells was much higher ranging from 13% of the lowest measured value when measured with taurocholate to approximately normal values with glycocholate.	Glycocholic Acid	194-206	galactosidase beta 1	Homo sapiens	12-30
6766461-1	1980	Enzyme immunoassay for cortisol was developed using beta-galactosidase as an enzyme label and m-maleimidobenzoyl derivatives of cortisol, i.e. cortisol-21-m-maleimidobenzoate (CT-MB) and cortisol-21-hemisuccinate conjugated with m-maleimidobenzoic acid through p-phenylenediamine linkage (CHS-MB), as the haptens coupled to sulfhydryl groups of the enzyme.	Hydrocortisone	23-31	galactosidase beta 1	Homo sapiens	52-70
6766461-4	1980	CT-MB-beta-galactosidase conjugate, however, showed not only a high immunoreactivity to the antibody but also displaced well with cortisol, showing maximum sensitivity of 1 microgram/dl with a 20-microliter sample size.	Hydrocortisone	130-138	galactosidase beta 1	Homo sapiens	6-24
6767344-2	1980	One of them, galactosylceramidase, is primarily responsible for degradation of galactosylceramide, galactosylsphingosine, and monogalactosyl-diglyceride, while the other, GM1-ganglioside beta-galactosidase, degrades GM1-ganglioside and asialo GM1-ganglioside.	monogalactosyl diglyceride	126-152	galactosidase beta 1	Homo sapiens	187-205
6767344-2	1980	One of them, galactosylceramidase, is primarily responsible for degradation of galactosylceramide, galactosylsphingosine, and monogalactosyl-diglyceride, while the other, GM1-ganglioside beta-galactosidase, degrades GM1-ganglioside and asialo GM1-ganglioside.	G(M1) Ganglioside	171-186	galactosidase beta 1	Homo sapiens	187-205
6778958-3	1980	Activity of PNP-beta-galactosidase in normal brain tissue, like that of cerebroside beta-galactosidase from the same source, was considerably more heat-stable than the activity of either 4-MU-beta-galactosidase or the predominant GM1 beta-D-galactosidase (EC 3.2.1.23).	G(M1) Ganglioside	230-233	galactosidase beta 1	Homo sapiens	16-34
6153145-0	1980	Immobilization of beta-galactosidase, albumin, and gamma-globulin on epoxy-activated acrylic beads.	acrylic	85-92	galactosidase beta 1	Homo sapiens	18-36
6153145-4	1980	For beta-galactosidase a saturation activity of 1300 U/g oxirane C was reached.	oxirane c	57-66	galactosidase beta 1	Homo sapiens	4-22
6778958-4	1980	Lac-cer and GM1, as well as 4-MU-gal and PNP-gal, were competitive inhibitors of human-brain cerebroside beta-galactosidase.	CDw17 antigen	0-7	galactosidase beta 1	Homo sapiens	105-123
6778958-4	1980	Lac-cer and GM1, as well as 4-MU-gal and PNP-gal, were competitive inhibitors of human-brain cerebroside beta-galactosidase.	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	105-123
6778958-4	1980	Lac-cer and GM1, as well as 4-MU-gal and PNP-gal, were competitive inhibitors of human-brain cerebroside beta-galactosidase.	4-methylumbelliferyl-galactopyranoside	28-36	galactosidase beta 1	Homo sapiens	105-123
7013165-3	1980	The labeled drug, galactosyl umbelliferone-PB (GUPB), is nonfluorescent under conditions of the assay; however, hydrolysis of the galactosyl moiety by bacterial beta-galactosidase yields a fluorescent product.	galactosyl umbelliferone-pb	18-45	galactosidase beta 1	Homo sapiens	161-179
7455622-3	1980	Indomethacin reduced the release of beta-glucuronidase, beta-galactosidase and beta-N-acetylglucosaminidase, diminished glucose consumption and lactate production, but showed no effect on the release of lactate dehydrogenase.	Indomethacin	0-12	galactosidase beta 1	Homo sapiens	56-74
118935-4	1979	Interferon production was inhibited to the same extent (99%) by pretreatment of the cells with beta-galactosidase or with neuraminidase followed by beta-galactosidase, suggesting that the critical event for activation of interferon production is the oxidation of exposed galactose residues on lymphocyte membrane.	Galactose	271-280	galactosidase beta 1	Homo sapiens	95-113
390656-3	1979	When beta-galactosidase was conjugated with choriomammotropin using the N-hydroxy-succinamide ester of m-maleimidobenzoic acid the affinity of the enzyme conjugate to beta-D-galactosylamine attached to agarose diminished markedly following incubation with antibody.	n-hydroxy-succinamide ester	72-99	galactosidase beta 1	Homo sapiens	5-23
117700-4	1979	beta-Galactosidase activity was deficient in cultured fibroblasts using [3H]GM1 ganglioside and [3H]ceramide-lactose as substrates.	Tritium	72-76	galactosidase beta 1	Homo sapiens	0-18
117700-4	1979	beta-Galactosidase activity was deficient in cultured fibroblasts using [3H]GM1 ganglioside and [3H]ceramide-lactose as substrates.	G(M1) Ganglioside	76-91	galactosidase beta 1	Homo sapiens	0-18
117700-4	1979	beta-Galactosidase activity was deficient in cultured fibroblasts using [3H]GM1 ganglioside and [3H]ceramide-lactose as substrates.	[3h]ceramide	96-108	galactosidase beta 1	Homo sapiens	0-18
117700-4	1979	beta-Galactosidase activity was deficient in cultured fibroblasts using [3H]GM1 ganglioside and [3H]ceramide-lactose as substrates.	Lactose	109-116	galactosidase beta 1	Homo sapiens	0-18
115863-6	1979	In connection with the enzymic hydrolysis of GM1 and GM2, we found that the hydrolysis of GM2 by human hepatic beta-N-acetylhexosaminidase A was severely inhibited by a buffer of high ionic strength, whereas no such inhibition was observed in the hydrolysis of GM1 by beta-galactosidase.	G(M1) Ganglioside	45-48	galactosidase beta 1	Homo sapiens	268-286
115863-6	1979	In connection with the enzymic hydrolysis of GM1 and GM2, we found that the hydrolysis of GM2 by human hepatic beta-N-acetylhexosaminidase A was severely inhibited by a buffer of high ionic strength, whereas no such inhibition was observed in the hydrolysis of GM1 by beta-galactosidase.	gm2	90-93	galactosidase beta 1	Homo sapiens	268-286
112098-2	1979	Coomassie blue staining of stroma components separated by sodium dodecyl sulfate-acrylamide gel electrophoresis indicates that treatment of red cells with endo-beta-galactosidase converts Protein 3, the anion transporter of the erythrocyte, to a more compact staining band.	Coomassie blue	0-14	galactosidase beta 1	Homo sapiens	160-178
112098-2	1979	Coomassie blue staining of stroma components separated by sodium dodecyl sulfate-acrylamide gel electrophoresis indicates that treatment of red cells with endo-beta-galactosidase converts Protein 3, the anion transporter of the erythrocyte, to a more compact staining band.	Sodium Dodecyl Sulfate	58-80	galactosidase beta 1	Homo sapiens	160-178
112098-1	1979	Endo-beta-galactosidase, a glycosidase that hydrolyzes Gal beta 1-4 GlcNAc linkages in glycoconjugates, has been used to probe the plasma membrane of human erythrocytes.	gal beta 1-4 glcnac	55-74	galactosidase beta 1	Homo sapiens	5-23
390656-3	1979	When beta-galactosidase was conjugated with choriomammotropin using the N-hydroxy-succinamide ester of m-maleimidobenzoic acid the affinity of the enzyme conjugate to beta-D-galactosylamine attached to agarose diminished markedly following incubation with antibody.	3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid	103-126	galactosidase beta 1	Homo sapiens	5-23
112098-2	1979	Coomassie blue staining of stroma components separated by sodium dodecyl sulfate-acrylamide gel electrophoresis indicates that treatment of red cells with endo-beta-galactosidase converts Protein 3, the anion transporter of the erythrocyte, to a more compact staining band.	Acrylamide	81-91	galactosidase beta 1	Homo sapiens	160-178
112098-4	1979	Following labeling of red cells with galactose oxidase + NaB3H4, 45 to 50% of the [3H]galactose residues can be released by endo-beta-galactosidase.	nab3h4	57-63	galactosidase beta 1	Homo sapiens	129-147
112098-4	1979	Following labeling of red cells with galactose oxidase + NaB3H4, 45 to 50% of the [3H]galactose residues can be released by endo-beta-galactosidase.	Tritium	60-62	galactosidase beta 1	Homo sapiens	129-147
390656-3	1979	When beta-galactosidase was conjugated with choriomammotropin using the N-hydroxy-succinamide ester of m-maleimidobenzoic acid the affinity of the enzyme conjugate to beta-D-galactosylamine attached to agarose diminished markedly following incubation with antibody.	galactosylamine	167-189	galactosidase beta 1	Homo sapiens	5-23
112098-4	1979	Following labeling of red cells with galactose oxidase + NaB3H4, 45 to 50% of the [3H]galactose residues can be released by endo-beta-galactosidase.	Galactose	37-46	galactosidase beta 1	Homo sapiens	129-147
390656-3	1979	When beta-galactosidase was conjugated with choriomammotropin using the N-hydroxy-succinamide ester of m-maleimidobenzoic acid the affinity of the enzyme conjugate to beta-D-galactosylamine attached to agarose diminished markedly following incubation with antibody.	Sepharose	202-209	galactosidase beta 1	Homo sapiens	5-23
107853-3	1979	At the beginning of the process the oil eliminated the biomass accumulation lag-phase connected with beta-galactosidase repression by glucose.	Oils	36-39	galactosidase beta 1	Homo sapiens	101-119
114170-3	1979	Recognition of alpha-N-acetylglucosaminidase by a cell-surface receptor specific for terminal galactose/N-acetylgalactosamine residues is supported by the observations (a) that neuraminidase pretreatment of the enzyme enhances endocytosis, (b) that beta-galactosidase treatment decreases endocytosis and (c) that neuraminidase pretreatment of hepatocytes decreases alpha-N-acetylglucosaminidase endocytosis.	Galactose	94-103	galactosidase beta 1	Homo sapiens	249-267
108135-1	1979	Meta-maleimidobenzoyl derivative of L-thyroxine methyl ester (MBTM) was synthesized and coupled to beta-galactosidase at molar ratio of over 5 to 1.	maleimidobenzoyl	5-21	galactosidase beta 1	Homo sapiens	99-117
108135-1	1979	Meta-maleimidobenzoyl derivative of L-thyroxine methyl ester (MBTM) was synthesized and coupled to beta-galactosidase at molar ratio of over 5 to 1.	Thyroxine Methyl Ester	36-60	galactosidase beta 1	Homo sapiens	99-117
108135-1	1979	Meta-maleimidobenzoyl derivative of L-thyroxine methyl ester (MBTM) was synthesized and coupled to beta-galactosidase at molar ratio of over 5 to 1.	mbtm	62-66	galactosidase beta 1	Homo sapiens	99-117
110764-0	1979	Lactose metabolism involving phospho-beta-galactosidase in Klebsiella.	Lactose	0-7	galactosidase beta 1	Homo sapiens	37-55
110764-1	1979	Klebsiella strain RE1755A is a Lac- Gal- mutant which has lost both of its lac operons, but possesses a gene specifying beta-galactosidase III, an enzyme which hydrolyzes o-nitrophenyl-beta-D-galactopyranoside but does not hydrolyze lactose.	2-nitrophenylgalactoside	171-209	galactosidase beta 1	Homo sapiens	120-138
110764-1	1979	Klebsiella strain RE1755A is a Lac- Gal- mutant which has lost both of its lac operons, but possesses a gene specifying beta-galactosidase III, an enzyme which hydrolyzes o-nitrophenyl-beta-D-galactopyranoside but does not hydrolyze lactose.	Lactose	233-240	galactosidase beta 1	Homo sapiens	120-138
110764-4	1979	Lactose utilization was shown to result from a pleiotropic mutation which also (i) permits galactose utilization and (ii) prevents induction of beta-galactosidase III synthesis by lactose.	Lactose	0-7	galactosidase beta 1	Homo sapiens	144-162
110764-5	1979	Evidence is presented suggesting that a phospho-beta-galactosidase enzyme is involved in lactose metabolism.	Lactose	89-96	galactosidase beta 1	Homo sapiens	48-66
452769-8	1979	In the genus Salmonella, ONPG-positive strains of sub-genus III and strains harboring a lactose-plasmid have a true beta-galactosidase.	Lactose	88-95	galactosidase beta 1	Homo sapiens	116-134
84682-2	1979	M15 protein lacks residues 11--41 and is a dimer; the active complex, like native beta-galactosidase, is tetrameric [Langley, K. E., & Zabin, I.	Adenosine Monophosphate	134-137	galactosidase beta 1	Homo sapiens	82-100
84682-6	1979	Treatment of native beta-galactosidase with trypsin, followed by reaction of the mixture with cyanogen bromide, yields intact CNBr2 as measured by its ability to complement M15 protein.	Cyanogen Bromide	94-110	galactosidase beta 1	Homo sapiens	20-38
84682-7	1979	Active CNBr2 is not obtained when urea-denatured beta-galactosidase is treated in the same way.	Urea	34-38	galactosidase beta 1	Homo sapiens	49-67
107853-3	1979	At the beginning of the process the oil eliminated the biomass accumulation lag-phase connected with beta-galactosidase repression by glucose.	Glucose	134-141	galactosidase beta 1	Homo sapiens	101-119
105984-4	1979	In some experiments the antigenic behavior of resultant beta-galactoside activity in lambda plac DNA-treated cells resembled that of mutant E. coli beta-galactosidase.	beta-galactoside	56-72	galactosidase beta 1	Homo sapiens	148-166
110596-5	1979	The increased release of beta-galactosidase by the kidney suggested that cadmium can damage some epithelial cells.	Cadmium	73-80	galactosidase beta 1	Homo sapiens	25-43
103660-2	1979	Unlabeled hormone competes with choriomammotropin-beta-galactosidase conjugate for antibody bound to polystyrene tubes.	Polystyrenes	101-112	galactosidase beta 1	Homo sapiens	50-68
118216-2	1979	beta-Galactosidase was conjugated to antibodies raised against rabbit Fc fragments using m-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS).	3-maleimidobenzoyl N-hydroxysuccinimide	89-134	galactosidase beta 1	Homo sapiens	0-18
104950-0	1979	p-Hydroxyphenylacetaldoxime, an inhibitor of beta-galactosidase, produced by actinomycetes.	4-Hydroxyphenylacetaldoxime	0-27	galactosidase beta 1	Homo sapiens	45-63
103801-3	1978	GM1-ganglioside beta-galactosidase activity was reduced to 1% of the control value in both the brain and liver of the affected fetus.	G(M1) Ganglioside	0-15	galactosidase beta 1	Homo sapiens	16-34
102644-2	1978	Its structure was determined by degradation with exo- and endoglycosidases, by mass spectrometric characterization of a nonasaccharide liberated by endo-beta-galactosidase, and by methylation analysis and mass spectrometry of permethylated glycolipids before and after enzymatic degradation.	Nonasaccharide Glc4Xyl3Gal2	120-134	galactosidase beta 1	Homo sapiens	153-171
99449-0	1978	Release of oligosaccharides from various glycosphingolipids by endo-beta-galactosidase.	Oligosaccharides	11-27	galactosidase beta 1	Homo sapiens	68-86
31052-5	1978	The other natural beta-galactoside substrates used in this investigation were different oligosaccharides, one glycopeptide and ceramide-beta-galactosidase.	beta-galactoside	18-34	galactosidase beta 1	Homo sapiens	136-154
99449-0	1978	Release of oligosaccharides from various glycosphingolipids by endo-beta-galactosidase.	Glycosphingolipids	41-59	galactosidase beta 1	Homo sapiens	68-86
29729-1	1978	Neutral beta-galactosidase was partially purified from liver of normal controls, a patient with Niemann-Pick disease type A and the previously described patient with lactosyl ceramidosis using Concanavalin A-Sepharose adsorption and Sephadex G-100 gel filtration.	sephadex	233-247	galactosidase beta 1	Homo sapiens	8-26
31052-6	1978	The beta-galactosidase forms with acidic pH optimum towards synthetic substrate (A forms) exhibit activity towards the natural substrate (except ceramide-beta-galactoside).	ceramide-beta-galactoside	145-170	galactosidase beta 1	Homo sapiens	4-22
31052-7	1978	The "neutral" beta-galactosidase with broad substrate specificity (B form) which includes beta-glucosides had no activity towards the natural substrates used.	beta-glucosides	90-105	galactosidase beta 1	Homo sapiens	14-32
31052-8	1978	It could also be shown that the activity towards ceramide-beta-galactoside was a third type of beta-galactosidase different from A and B forms.	ceramide-beta-galactoside	49-74	galactosidase beta 1	Homo sapiens	95-113
731265-8	1978	These findings are consistent with the known substrate specificities of the two acidic beta-galactosidases in human tissues; galactosylceramide is hydrolyzed almost exclusively by galactosylceramidase, while lactosylceramide can be hydrolyzed by both galactosylceramidase and GM1-ganglioside beta-galactosidase.	Galactosylceramides	125-143	galactosidase beta 1	Homo sapiens	87-105
731265-8	1978	These findings are consistent with the known substrate specificities of the two acidic beta-galactosidases in human tissues; galactosylceramide is hydrolyzed almost exclusively by galactosylceramidase, while lactosylceramide can be hydrolyzed by both galactosylceramidase and GM1-ganglioside beta-galactosidase.	CDw17 antigen	127-143	galactosidase beta 1	Homo sapiens	87-105
731265-8	1978	These findings are consistent with the known substrate specificities of the two acidic beta-galactosidases in human tissues; galactosylceramide is hydrolyzed almost exclusively by galactosylceramidase, while lactosylceramide can be hydrolyzed by both galactosylceramidase and GM1-ganglioside beta-galactosidase.	G(M1) Ganglioside	276-291	galactosidase beta 1	Homo sapiens	87-105
104712-3	1978	beta-Galactosidase A2 and A3 were purified to final specific activities of 45.5 and 20.6 mumol/min per mg respectively with 4-methylumbelliferyl beta-D-galactopyranoside as substrate.	4-methylumbelliferyl-galactopyranoside	124-169	galactosidase beta 1	Homo sapiens	0-18
104712-22	1978	beta-Galactosidase A2 contained 7.5% carbohydrate by weight and sialic acid, D-galactose, D-glucosamine and D-mannose were present in the molar proportions 1.1:1.0:1.7:2.7.	Carbohydrates	37-49	galactosidase beta 1	Homo sapiens	0-18
104712-22	1978	beta-Galactosidase A2 contained 7.5% carbohydrate by weight and sialic acid, D-galactose, D-glucosamine and D-mannose were present in the molar proportions 1.1:1.0:1.7:2.7.	N-Acetylneuraminic Acid	64-75	galactosidase beta 1	Homo sapiens	0-18
104712-22	1978	beta-Galactosidase A2 contained 7.5% carbohydrate by weight and sialic acid, D-galactose, D-glucosamine and D-mannose were present in the molar proportions 1.1:1.0:1.7:2.7.	Mannose	108-117	galactosidase beta 1	Homo sapiens	0-18
29729-8	1978	These data suggest that neutral beta-galactosidase may have an in vivo role in the cleavage of lactosyl ceramide and that a deficiency of this activity may be related to the lactosyl ceramide accumulation observed in the patient with lactosyl ceramidosis.	CDw17 antigen	95-112	galactosidase beta 1	Homo sapiens	32-50
29729-8	1978	These data suggest that neutral beta-galactosidase may have an in vivo role in the cleavage of lactosyl ceramide and that a deficiency of this activity may be related to the lactosyl ceramide accumulation observed in the patient with lactosyl ceramidosis.	CDw17 antigen	174-191	galactosidase beta 1	Homo sapiens	32-50
97290-0	1978	Methionine 500, the site of covalent attachment of an active site-directed reagent of beta-galactosidase.	Methionine	0-10	galactosidase beta 1	Homo sapiens	86-104
83795-1	1978	The residual liver acid beta-galactosidase (beta-gal) activity from a case of feline GM1 gangliosidosis was partially purified and characterized with respect to its pH optimum, kinetic properties, thermostability, isoelectric point, molecular weight, and antigenicity.	G(M1) Ganglioside	85-88	galactosidase beta 1	Homo sapiens	24-42
83795-1	1978	The residual liver acid beta-galactosidase (beta-gal) activity from a case of feline GM1 gangliosidosis was partially purified and characterized with respect to its pH optimum, kinetic properties, thermostability, isoelectric point, molecular weight, and antigenicity.	G(M1) Ganglioside	85-88	galactosidase beta 1	Homo sapiens	24-32
83795-4	1978	The results suggest that the mutation in the Birmingham GM1 cat is structural and that the residual enzyme activity is a structurally altered acid beta-gal.	G(M1) Ganglioside	56-59	galactosidase beta 1	Homo sapiens	147-155
97290-1	1978	The site of attachment to beta-galactosidase of the active site-directed inhibitor, beta-D-galactopyranosylmethyl p-nitrophenyl triazene, was determined.	beta-D-galactopyranosylmethyl-4-nitrophenyltriazene	84-136	galactosidase beta 1	Homo sapiens	26-44
97293-2	1978	The amino acid sequence of 72 chymotryptic peptides isolated from 14C-, 3H-labeled carboxymethyl-beta-galactosidase has been determined.	Peptides	43-51	galactosidase beta 1	Homo sapiens	97-115
97293-2	1978	The amino acid sequence of 72 chymotryptic peptides isolated from 14C-, 3H-labeled carboxymethyl-beta-galactosidase has been determined.	Carbon-14	66-69	galactosidase beta 1	Homo sapiens	97-115
97293-2	1978	The amino acid sequence of 72 chymotryptic peptides isolated from 14C-, 3H-labeled carboxymethyl-beta-galactosidase has been determined.	Tritium	72-74	galactosidase beta 1	Homo sapiens	97-115
97294-3	1978	All of the 24 cyanogen bromide peptides of beta-galactosidase have been isolated in pure form.	Cyanogen Bromide	14-30	galactosidase beta 1	Homo sapiens	43-61
97296-3	1978	The amino acid sequence in the 8 cyanogen bromide peptides comprising the central segment of beta-galactosidase is presented.	Cyanogen Bromide	33-49	galactosidase beta 1	Homo sapiens	93-111
27585-0	1978	Effect of hydrocortisone and thyroxine on arylsulphatases and beta-galactosidase of primary cell cultures of neuronal and glial types.	Hydrocortisone	10-24	galactosidase beta 1	Homo sapiens	62-80
27358-0	1978	Dependence upon pH of steady-state parameters for the beta-galactosidase-catalysed hydrolyses of beta-D-galactopyranosyl derivatives of different chemical types.	beta-d-galactopyranosyl	97-120	galactosidase beta 1	Homo sapiens	54-72
27358-1	1978	The effect of pH upon the beta-galactosidase-catalyzed hydrolyses of aryl galactosides is essentially similar for each of the three steps of their hydrolysis.	aryl galactosides	69-86	galactosidase beta 1	Homo sapiens	26-44
27585-0	1978	Effect of hydrocortisone and thyroxine on arylsulphatases and beta-galactosidase of primary cell cultures of neuronal and glial types.	Thyroxine	29-38	galactosidase beta 1	Homo sapiens	62-80
27787-4	1978	Because the soluble beta-glucosidase, beta-xylosidase, and a portion of the beta-galactosidase activities from control human liver all cochromatographed on a gel filtration column of Sephadex G-200, it is suggested that these activities all reside in a single enzyme, analogous to the situation described in a number of nonhuman, mammalian tissues.	sephadex	183-197	galactosidase beta 1	Homo sapiens	76-94
96823-0	1978	Regulation of the in vitro synthesis of the alpha-peptide of beta-galactosidase directed by a restriction fragment of the lactose operon.	Lactose	122-129	galactosidase beta 1	Homo sapiens	61-79
27879-0	1978	The abnormalities of beta-galactosidase in GM1-gangliosidoses.	G(M1) Ganglioside	43-46	galactosidase beta 1	Homo sapiens	21-39
27879-1	1978	The activity of GM1 beta-galactosidase in the brain and liver of patients with GM1-gangliosidosis was assayed using GM1-ganglioside tritiated in the terminal galactose.	G(M1) Ganglioside	16-19	galactosidase beta 1	Homo sapiens	20-38
27879-1	1978	The activity of GM1 beta-galactosidase in the brain and liver of patients with GM1-gangliosidosis was assayed using GM1-ganglioside tritiated in the terminal galactose.	G(M1) Ganglioside	116-131	galactosidase beta 1	Homo sapiens	20-38
27879-1	1978	The activity of GM1 beta-galactosidase in the brain and liver of patients with GM1-gangliosidosis was assayed using GM1-ganglioside tritiated in the terminal galactose.	Galactose	158-167	galactosidase beta 1	Homo sapiens	20-38
417994-1	1978	Total lactosyl ceramide beta-galactosidase (LC) activity from normal and pathologic human leukocytes and tissues was subdivided into LC I (EC 3.2.1.46) and LC II (EC 3.2.1.23) activity by means of specific inhibition of LC II with 5 mM p-nitrophenyl-beta-D-galactoside (Ki = 1.5 mM).	CDw17 antigen	6-23	galactosidase beta 1	Homo sapiens	24-42
413573-0	1978	Purification and characterization of GM1 ganglioside beta-galactosidase from normal feline liver and brain.	G(M1) Ganglioside	37-40	galactosidase beta 1	Homo sapiens	53-71
663933-1	1978	A mannose-containing sialooligosaccharide has been isolated from the urine of a patient with a newly recognized mucolipidosis which showed a low liver beta-galactosidase activity and hyperglycopeptiduria.	Mannose	2-9	galactosidase beta 1	Homo sapiens	151-169
663933-1	1978	A mannose-containing sialooligosaccharide has been isolated from the urine of a patient with a newly recognized mucolipidosis which showed a low liver beta-galactosidase activity and hyperglycopeptiduria.	sialooligosaccharides	21-41	galactosidase beta 1	Homo sapiens	151-169
413573-1	1978	GM1 ganglioside beta-galactosidase (GM1-beta-galactosidase) was purified from normal cat brain and liver by a combination of classical and affinity procedures.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	16-34
413573-1	1978	GM1 ganglioside beta-galactosidase (GM1-beta-galactosidase) was purified from normal cat brain and liver by a combination of classical and affinity procedures.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	40-58
413573-6	1978	Both liver and brain GM1-beta-galactosidase(s) eluted as sharp symmetrical peaks from Sephadex G-200 with molecular weights of 250 000 +/- 50 000.	sephadex	86-100	galactosidase beta 1	Homo sapiens	25-43
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	4-methylumbelliferyl-galactopyranoside	31-76	galactosidase beta 1	Homo sapiens	123-141
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	4-methylumbelliferyl-galactopyranoside	31-76	galactosidase beta 1	Homo sapiens	173-191
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	4-methylumbelliferyl-galactopyranoside	78-86	galactosidase beta 1	Homo sapiens	123-141
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	4-methylumbelliferyl-galactopyranoside	78-86	galactosidase beta 1	Homo sapiens	173-191
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	G(M1) Ganglioside	119-122	galactosidase beta 1	Homo sapiens	123-141
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	G(M1) Ganglioside	119-122	galactosidase beta 1	Homo sapiens	173-191
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	G(M1) Ganglioside	169-172	galactosidase beta 1	Homo sapiens	123-141
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	4-methylumbelliferyl-galactopyranoside	207-215	galactosidase beta 1	Homo sapiens	123-141
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	Tritium	244-246	galactosidase beta 1	Homo sapiens	123-141
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	G(M1) Ganglioside	247-262	galactosidase beta 1	Homo sapiens	123-141
413833-2	1978	The action of different effectors, glycosides, and alcohols on the reactions catalyzed by beta-galactosidase is analyzed in this paper.	Glycosides	35-45	galactosidase beta 1	Homo sapiens	90-108
413833-2	1978	The action of different effectors, glycosides, and alcohols on the reactions catalyzed by beta-galactosidase is analyzed in this paper.	Alcohols	51-59	galactosidase beta 1	Homo sapiens	90-108
413833-6	1978	The analysis of the data indicates that the active center of beta-galactosidase is made up of two subsites: a galactose and a glucose subsite.	Galactose	110-119	galactosidase beta 1	Homo sapiens	61-79
413833-6	1978	The analysis of the data indicates that the active center of beta-galactosidase is made up of two subsites: a galactose and a glucose subsite.	Glucose	126-133	galactosidase beta 1	Homo sapiens	61-79
411612-0	1977	GM1-ganglioside beta-galactosidase in leukocytes and cultured fibroblasts.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	16-34
732308-5	1978	Incubation of VCN-treated marrow with either beta-galactosidase or trypsin had no effect on the VCN-induced reduction in CFUs.	polyacrylonitrile	14-17	galactosidase beta 1	Homo sapiens	45-63
414740-2	1977	A new method was devised for the estimation of human galactosylceramide, lactosylceramide, and GMI-ganglioside beta-galactosidase activities in the presence of their mouse counterparts, which takes advantage of the reproducible specific activity of lysosomal hydrolases under a given set of culture conditions and is based on differences in both pH optima and sensitivity to chloride ion.	gmi-ganglioside	95-110	galactosidase beta 1	Homo sapiens	111-129
414740-2	1977	A new method was devised for the estimation of human galactosylceramide, lactosylceramide, and GMI-ganglioside beta-galactosidase activities in the presence of their mouse counterparts, which takes advantage of the reproducible specific activity of lysosomal hydrolases under a given set of culture conditions and is based on differences in both pH optima and sensitivity to chloride ion.	Chlorides	375-383	galactosidase beta 1	Homo sapiens	111-129
411612-0	1977	GM1-ganglioside beta-galactosidase in leukocytes and cultured fibroblasts.	Gangliosides	4-15	galactosidase beta 1	Homo sapiens	16-34
71736-1	1977	The immune response to beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23)is characterized by a wave of early help followed by a wave of suppression to a subsequent in vitro challenge with galactosidase-fluorescein.	Fluorescein	221-232	galactosidase beta 1	Homo sapiens	23-41
908752-3	1977	Results presented here show that mannose-6-phosphate is also a potent inhibitor of pinocytosis of the following enzyme preparations: (a) beta-glucuronidase from human spleen, liver, placenta, and urine; (b) beta-hexosaminidase and beta-galactosidase from human platelets; (c) beta-hexosaminidase from human fibroblast secretions.	mannose-6-phosphate	33-52	galactosidase beta 1	Homo sapiens	231-249
596013-1	1977	Differential diagnosis of enterobacteria is based on the determination of beta-galactosidase enzyme, hydrolyzing lactose in the nutrient substrates; however, the tests suggested for its determination are time consuming and their use in practice is limited.	Lactose	113-120	galactosidase beta 1	Homo sapiens	74-92
31273-3	1977	Sphingolipid catabolism was evaluated in fetal lung and brain through the measurement of relevant acid hydrolases (arylsulfatase A, beta-galactosidase, and hexosaminidase).	Sphingolipids	0-12	galactosidase beta 1	Homo sapiens	132-170
409573-2	1977	We have demonstrated complete inhibition of GM1 ganglioside beta-galactosidase activity in vitro by both heparan sulfate and dermatan sulfate, but the effect on lactosylceramide and galactosylceramide hydrolysis was less marked.	G(M1) Ganglioside	44-59	galactosidase beta 1	Homo sapiens	60-78
409573-2	1977	We have demonstrated complete inhibition of GM1 ganglioside beta-galactosidase activity in vitro by both heparan sulfate and dermatan sulfate, but the effect on lactosylceramide and galactosylceramide hydrolysis was less marked.	Heparitin Sulfate	105-120	galactosidase beta 1	Homo sapiens	60-78
409573-2	1977	We have demonstrated complete inhibition of GM1 ganglioside beta-galactosidase activity in vitro by both heparan sulfate and dermatan sulfate, but the effect on lactosylceramide and galactosylceramide hydrolysis was less marked.	Dermatan Sulfate	125-141	galactosidase beta 1	Homo sapiens	60-78
191258-9	1977	Preincubation with neuraminidase had no effect on the elution profiles of six liver hydrolases whereas the major isoenzymes of alpha-mannosidase, beta-galactosidase and alpha-L-arabinofuranosidase were eluted at markedly lower salt concentrations.	Salts	227-231	galactosidase beta 1	Homo sapiens	146-164
890133-2	1977	The intraperitoneal injection of tyrocalcitonine (TCT), deoxycorticosterone (DOCS), hydrocortisone (HC), and somatotropic hormone (STH) influenced both the activity of beta-galactosidase, beta-glucosidase, and hyaluronidase, the the functional state of thy lysosomal membranes of the connective tissues under investigation.	tyrocalcitonine	33-48	galactosidase beta 1	Homo sapiens	168-186
890133-2	1977	The intraperitoneal injection of tyrocalcitonine (TCT), deoxycorticosterone (DOCS), hydrocortisone (HC), and somatotropic hormone (STH) influenced both the activity of beta-galactosidase, beta-glucosidase, and hyaluronidase, the the functional state of thy lysosomal membranes of the connective tissues under investigation.	Desoxycorticosterone	56-75	galactosidase beta 1	Homo sapiens	168-186
890133-2	1977	The intraperitoneal injection of tyrocalcitonine (TCT), deoxycorticosterone (DOCS), hydrocortisone (HC), and somatotropic hormone (STH) influenced both the activity of beta-galactosidase, beta-glucosidase, and hyaluronidase, the the functional state of thy lysosomal membranes of the connective tissues under investigation.	Desoxycorticosterone	77-81	galactosidase beta 1	Homo sapiens	168-186
890133-2	1977	The intraperitoneal injection of tyrocalcitonine (TCT), deoxycorticosterone (DOCS), hydrocortisone (HC), and somatotropic hormone (STH) influenced both the activity of beta-galactosidase, beta-glucosidase, and hyaluronidase, the the functional state of thy lysosomal membranes of the connective tissues under investigation.	Hydrocortisone	84-98	galactosidase beta 1	Homo sapiens	168-186
890133-2	1977	The intraperitoneal injection of tyrocalcitonine (TCT), deoxycorticosterone (DOCS), hydrocortisone (HC), and somatotropic hormone (STH) influenced both the activity of beta-galactosidase, beta-glucosidase, and hyaluronidase, the the functional state of thy lysosomal membranes of the connective tissues under investigation.	STH	131-134	galactosidase beta 1	Homo sapiens	168-186
330219-0	1977	The inactivation of beta-galactosidase by N-bromoacetyl-beta-D-glucosylamine.	N-bromoacetylglucosamine	42-76	galactosidase beta 1	Homo sapiens	20-38
13910-6	1977	Relative specific activities of GM1-ganglioside beta-galactosidase toward the same series of the substrates were 0.3, 78, 19, 100, 150 and 240; However, the optimal assay conditions for any given natural substrate were sufficiently different for each beta-galactosidase so that diagnostic assays for the two genetic diseases due to beta-galactosidase deficiencies could be carried out in whole tissues.	G(M1) Ganglioside	32-47	galactosidase beta 1	Homo sapiens	48-66
13910-6	1977	Relative specific activities of GM1-ganglioside beta-galactosidase toward the same series of the substrates were 0.3, 78, 19, 100, 150 and 240; However, the optimal assay conditions for any given natural substrate were sufficiently different for each beta-galactosidase so that diagnostic assays for the two genetic diseases due to beta-galactosidase deficiencies could be carried out in whole tissues.	G(M1) Ganglioside	32-47	galactosidase beta 1	Homo sapiens	251-269
19090-0	1977	[Soluble and immobilized beta-galactosidase; differential kinetics towards p-nitrophenyl-beta-D-galactoside].	4-nitrophenylgalactoside	75-107	galactosidase beta 1	Homo sapiens	25-43
827447-18	1976	However, the removal of terminal galactose with beta-galactosidase affects I-activity only slightly.	Galactose	33-42	galactosidase beta 1	Homo sapiens	48-66
827294-0	1976	The role of glycosidically bound mannose in the assimilation of beta-galactosidase by generalized gangliosidosis fibroblasts.	Mannose	33-40	galactosidase beta 1	Homo sapiens	64-82
11913-1	1976	Colorimetric methods using 4-nitrophenyl-glycoside substrates for the assay of beta-galactosidase and N-acetyl-beta-glucosaminidase in human urine are described.	4-nitrophenyl-glycoside	27-50	galactosidase beta 1	Homo sapiens	79-97
790385-1	1976	We have isolated a series of strains in which the lacZ gene has been fused to one of the maltose operons, such that the synthesis of beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23) is inducible by maltose.	Maltose	89-96	galactosidase beta 1	Homo sapiens	133-151
984856-0	1976	Stimulation by spermidine of the DNA-directed in vitro synthesis of beta-galactosidase.	Spermidine	15-25	galactosidase beta 1	Homo sapiens	68-86
790385-1	1976	We have isolated a series of strains in which the lacZ gene has been fused to one of the maltose operons, such that the synthesis of beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23) is inducible by maltose.	Maltose	219-226	galactosidase beta 1	Homo sapiens	133-151
954131-1	1976	A template DNA from phage lambdah80dlacp5 coding for the in vitro synthesis of beta-galactosidase was used to study the effect of DNA methylation by the alkylating agent, dimethyl sulfate (DMS).	dimethyl sulfate	171-187	galactosidase beta 1	Homo sapiens	79-97
822669-2	1976	Terminal sialic acid and galactose were released by stepwise hydrolysis with neuraminidase and beta-galactosidase.	N-Acetylneuraminic Acid	9-20	galactosidase beta 1	Homo sapiens	95-113
822669-2	1976	Terminal sialic acid and galactose were released by stepwise hydrolysis with neuraminidase and beta-galactosidase.	Galactose	25-34	galactosidase beta 1	Homo sapiens	95-113
962854-3	1976	It has the same ability to hydrolyse GM1 ganglioside as the two other acid beta-galactosidase forms.	G(M1) Ganglioside	37-52	galactosidase beta 1	Homo sapiens	75-93
962854-5	1976	The low-molecular-weight forms of acid beta-galactosidase undergo salt-dependent aggregation.	Salts	66-70	galactosidase beta 1	Homo sapiens	39-57
962854-10	1976	The neutral beta-galactosidase activity can be resolved into two forms by DEAE-cellulose chromatography.	DEAE-Cellulose	74-88	galactosidase beta 1	Homo sapiens	12-30
954131-1	1976	A template DNA from phage lambdah80dlacp5 coding for the in vitro synthesis of beta-galactosidase was used to study the effect of DNA methylation by the alkylating agent, dimethyl sulfate (DMS).	dimethyl sulfate	189-192	galactosidase beta 1	Homo sapiens	79-97
779770-1	1976	Aminoethylated beta-galactosidase from Escherichia coli was cleaved by CNBr.	Cyanogen Bromide	71-75	galactosidase beta 1	Homo sapiens	15-33
20673-1	1976	(+)--Cyanidanol, a water-soluble flavonoid, when added to cultured skin fibroblasts of a patient with I-cell disease raised the intracellular concentration of beta-galactosidase but did not affect the distribution of <protein-id="410">arylsulfatase.	Catechin	0-15	galactosidase beta 1	Homo sapiens	159-177
779770-0	1976	A cyanogen bromide fragment of beta-galactosidase from Escherichia coli with alpha-donor activity in complementation of the enzyme from mutant M15.	Cyanogen Bromide	2-18	galactosidase beta 1	Homo sapiens	31-49
176142-2	1976	More beta-galactosidase messenger ribonucleic acid (as determined by hybridization) is made in fully induced lacOc mutants and in trp-lac fusions than is eventually translated into enzyme.	Tryptophan	130-133	galactosidase beta 1	Homo sapiens	5-23
814123-5	1976	The purified activator stimulates the hydrolysis of GM1 by beta-galactosidase, GM2 by beta-hexosaminidase, as well as ceramide trihexoside by alpha-galactosidase A or B.	G(M1) Ganglioside	52-55	galactosidase beta 1	Homo sapiens	59-77
1253978-0	1976	2,6-anhydro-1-diazo-1-deoxy-D-glycero-L-manno-heptitol: a specific blocking agent for the active site of beta-galactosidase.	2,6-anhydro-1-diazo-1-deoxy-d-glycero-l-manno-heptitol	0-54	galactosidase beta 1	Homo sapiens	105-123
1044283-1	1976	Lactase (beta-galactosidase) was attached to the inner surface of nylon tubing.	Nylons	66-71	galactosidase beta 1	Homo sapiens	9-27
812551-0	1975	Effect of bile salts on lactosylceramide beta-galactosidase activities in human brain, liver and cultured skin fibroblasts.	Bile Acids and Salts	10-20	galactosidase beta 1	Homo sapiens	41-59
812551-5	1975	In place of crude taurocholate the pure salts of glycodeoxycholate, taurodeoxycholate and taurochenodeoxycholate worked even better to stimulate the second lactosylceramide beta-galactosidase activity and GM1 gangliosidosis patients exhibiting little if any activity.	Glycodeoxycholic Acid	49-66	galactosidase beta 1	Homo sapiens	173-191
812551-5	1975	In place of crude taurocholate the pure salts of glycodeoxycholate, taurodeoxycholate and taurochenodeoxycholate worked even better to stimulate the second lactosylceramide beta-galactosidase activity and GM1 gangliosidosis patients exhibiting little if any activity.	Taurodeoxycholic Acid	68-85	galactosidase beta 1	Homo sapiens	173-191
812551-5	1975	In place of crude taurocholate the pure salts of glycodeoxycholate, taurodeoxycholate and taurochenodeoxycholate worked even better to stimulate the second lactosylceramide beta-galactosidase activity and GM1 gangliosidosis patients exhibiting little if any activity.	Taurochenodeoxycholic Acid	90-112	galactosidase beta 1	Homo sapiens	173-191
821451-5	1975	In leukocytes, the activity of p-nitrophenyl-beta-galactosidase was below 5%, and that of GM1-ganglioside beta-galactosidase below 1% of values obtained in controls.	G(M1) Ganglioside	90-105	galactosidase beta 1	Homo sapiens	106-124
817853-2	1976	In fibroblasts, ganglioside GM1 beta-galactosidase activity averaged 7% of the normal mean while asialofetuin beta-galactosidase and 4-methylumbe lifery-beta-galactosidase averaged 1.4% and 3.5%, respectively.	G(M1) Ganglioside	16-31	galactosidase beta 1	Homo sapiens	32-50
817853-3	1976	Activities for all three substrates in leucocytes from both her parents were close to 50% of the normal mean indicating that the patient is homozygous for a mutation (or mutations) affecting GM1 beta-galactosidase.	G(M1) Ganglioside	191-194	galactosidase beta 1	Homo sapiens	195-213
1005366-0	1976	[Hydrolysis of lactose by immobilized beta-galactosidase].	Lactose	15-22	galactosidase beta 1	Homo sapiens	38-56
939225-2	1976	The high-molecular-weight acidic beta-galactosidase form was converted into the smaller major form by sodium dodecyl sulfate treatment.	Sodium Dodecyl Sulfate	102-124	galactosidase beta 1	Homo sapiens	33-51
11192-2	1976	Carboxymethylated Escherichia coli beta-galactosidase EC 3.2.1.23 could be broken to polypeptides of fairly uniform size (average molecular weight about 22,000 daltons) by heating for less than or equal to 8 h at 100 degrees C and pH 7.5 IN 8 M-urea.	Urea	245-249	galactosidase beta 1	Homo sapiens	35-53
799231-0	1976	Lactose reduction of milk by fiber-entrapped beta-galactosidase.	Lactose	0-7	galactosidase beta 1	Homo sapiens	45-63
1206002-0	1975	Isoflavone rhamuniosides inhibitors of beta-galactosidase produced by actinomycetes.	Isoflavones	0-10	galactosidase beta 1	Homo sapiens	39-57
1206002-0	1975	Isoflavone rhamuniosides inhibitors of beta-galactosidase produced by actinomycetes.	rhamuniosides	11-24	galactosidase beta 1	Homo sapiens	39-57
1177265-11	1975	Crude sodium taurocholate was far more effective than pure taurocholate in stimulating hydrolysis of the three glycosphingolipids by the beta-galactosidase.	Taurocholic Acid	6-25	galactosidase beta 1	Homo sapiens	137-155
1177265-11	1975	Crude sodium taurocholate was far more effective than pure taurocholate in stimulating hydrolysis of the three glycosphingolipids by the beta-galactosidase.	Taurocholic Acid	13-25	galactosidase beta 1	Homo sapiens	137-155
1742-0	1975	[Preparation and properties of beta-galactosidase linked covalently with KM-cellulose].	km-cellulose	73-85	galactosidase beta 1	Homo sapiens	31-49
1742-1	1975	Fungal beta-galactosidase was immobilized by covalent binding with KM-cellulose.	km-cellulose	67-79	galactosidase beta 1	Homo sapiens	7-25
1043782-0	1975	Flow kinetics of beta-galactosidase chemically attached to nylon tubing.	Nylons	59-64	galactosidase beta 1	Homo sapiens	17-35
1043782-1	1975	Beta-Galactosidase (EC 3.2.1.23) has been attached covalently to the inner surface of nylon tubing.	Nylons	86-91	galactosidase beta 1	Homo sapiens	0-18
1174525-0	1975	Activity of human hepatic beta-galactosidase toward natural glycosphingolipid substrates.	Glycosphingolipids	60-77	galactosidase beta 1	Homo sapiens	26-44
1213985-5	1975	It produced galactose on incubation  with beta-galactosidase, and N-acetyllactosamine and aspartic acid on incubation with 4-L-aspartylglycosylamine amindo hydrolase.	Galactose	12-21	galactosidase beta 1	Homo sapiens	42-60
1174525-12	1975	Crude sodium taurocholate was far more effective than pure taurocholate in stimualting hydrolysis of the three glycosphingolipids by the beta-galactosidase.	Taurocholic Acid	6-25	galactosidase beta 1	Homo sapiens	137-155
1174525-12	1975	Crude sodium taurocholate was far more effective than pure taurocholate in stimualting hydrolysis of the three glycosphingolipids by the beta-galactosidase.	Taurocholic Acid	13-25	galactosidase beta 1	Homo sapiens	137-155
1091637-3	1975	Intracistronic alpha-complementation between a cyanogen bromide digest of beta-galactosidase and an extract of the lac Zminus operator-proximal deletion mutant M15 was used to monitor the purification of a cyanogen bromide peptide (CB2) responsible for the complementation.	Cyanogen Bromide	47-63	galactosidase beta 1	Homo sapiens	74-92
1150547-0	1975	Pyridindolol, a new beta-galactosidase inhibitor produced by actinomycetes.	pyridindolol	0-12	galactosidase beta 1	Homo sapiens	20-38
164897-0	1975	Different cyclic adenosine 3",5"-monophosphate requirements for induction of beta-galactosidase and tryptophanase.	Cyclic AMP	10-46	galactosidase beta 1	Homo sapiens	77-95
164897-6	1975	Although external cAMP concentrations, 10 times higher than the usual intracellular levels, are required for induction of beta-galactosidase and tryptophanase, the difference of requirements of cAMP is maintained.	Cyclic AMP	18-22	galactosidase beta 1	Homo sapiens	122-140
238516-0	1975	The beta-galactosidase-catalyzed hydrolysis of o-nitrophenol-beta-D-galactoside at subzero temperatures: evidence for a galactosyl-enzyme intermediate.	o-nitrophenol-beta-d-galactoside	47-79	galactosidase beta 1	Homo sapiens	4-22
236034-2	1975	Evidence is presented for the existence of three distinct mammalian glycosphingolipid beta-galactosidase responsible for the hydrolysis of galactosylceramide, lactosylceramide and GM1 gangliside, respectively.	Galactosylceramides	139-157	galactosidase beta 1	Homo sapiens	86-104
236034-2	1975	Evidence is presented for the existence of three distinct mammalian glycosphingolipid beta-galactosidase responsible for the hydrolysis of galactosylceramide, lactosylceramide and GM1 gangliside, respectively.	CDw17 antigen	141-157	galactosidase beta 1	Homo sapiens	86-104
236034-2	1975	Evidence is presented for the existence of three distinct mammalian glycosphingolipid beta-galactosidase responsible for the hydrolysis of galactosylceramide, lactosylceramide and GM1 gangliside, respectively.	gm1 gangliside	180-194	galactosidase beta 1	Homo sapiens	86-104
1091637-3	1975	Intracistronic alpha-complementation between a cyanogen bromide digest of beta-galactosidase and an extract of the lac Zminus operator-proximal deletion mutant M15 was used to monitor the purification of a cyanogen bromide peptide (CB2) responsible for the complementation.	Cyanogen Bromide	206-222	galactosidase beta 1	Homo sapiens	74-92
4214813-0	1974	GM1 ganglioside beta-galactosidase.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	16-34
123040-0	1975	Chloride ions cancel out inhibition of beta-galactosidase activity by acid mucopolyaccharides.	Chlorides	0-8	galactosidase beta 1	Homo sapiens	39-57
123040-0	1975	Chloride ions cancel out inhibition of beta-galactosidase activity by acid mucopolyaccharides.	acid mucopolyaccharides	70-93	galactosidase beta 1	Homo sapiens	39-57
811282-0	1975	Correction of accumulation of sulfate-containing compounds in cultured generalized gangliosidosis fibroblasts by beta-galactosidase.	Sulfates	30-37	galactosidase beta 1	Homo sapiens	113-131
1093175-1	1975	In previous studies, a cyanogen bromide peptide derived from amino-acid residues 3-92 of beta-galactosidase (EC 3.2.1.23; beta-D-galactoside galactohydrolase) was shown to have alpha-donor activity in intracistronic alpha-complementation.	Cyanogen Bromide	23-39	galactosidase beta 1	Homo sapiens	89-107
1093175-3	1975	This is demonstrated by the isolation and sequence determination of a cyanogen bromide peptide from the M15 protein, which is identical to the corresponding peptide from beta-galactosidase except for the missing amino acids.	Cyanogen Bromide	70-86	galactosidase beta 1	Homo sapiens	170-188
804170-6	1975	Beta-Galactosidase from the patient had a Km that was higher then normal; 5-fold higher with ganglioside GM1 and 2-fold higher with 4-methylumbelliferyl beta-galactoside.	Gangliosides	93-104	galactosidase beta 1	Homo sapiens	0-18
804170-6	1975	Beta-Galactosidase from the patient had a Km that was higher then normal; 5-fold higher with ganglioside GM1 and 2-fold higher with 4-methylumbelliferyl beta-galactoside.	G(M1) Ganglioside	105-108	galactosidase beta 1	Homo sapiens	0-18
804170-6	1975	Beta-Galactosidase from the patient had a Km that was higher then normal; 5-fold higher with ganglioside GM1 and 2-fold higher with 4-methylumbelliferyl beta-galactoside.	4-methylumbelliferyl-galactopyranoside	132-169	galactosidase beta 1	Homo sapiens	0-18
4616952-1	1974	Adam Kepes suggested that the cellular transport and hydrolysis of orthonitrophenyl-beta-d-galactopyranoside is powered by the counterflux of the d-galactose resulting from beta-galactosidase action within the cell.	orthonitrophenyl-beta-d-galactopyranoside	67-108	galactosidase beta 1	Homo sapiens	173-191
4616952-1	1974	Adam Kepes suggested that the cellular transport and hydrolysis of orthonitrophenyl-beta-d-galactopyranoside is powered by the counterflux of the d-galactose resulting from beta-galactosidase action within the cell.	Galactose	146-157	galactosidase beta 1	Homo sapiens	173-191
4373526-0	1974	The effects of beta-galactosidase activity and cyclic AMP on lactose-accelerated death.	Lactose	61-68	galactosidase beta 1	Homo sapiens	15-33
4406193-0	1974	Hydrolysis of lactose in acid whey using beta-galactosidase immobilized on porous glass particles: preparation and characterization of a reusable catalyst for the production of low-lactose dairy products.	Lactose	14-21	galactosidase beta 1	Homo sapiens	41-59
4459261-0	1974	An enzyme-immunoassay of antibody specific for adenosine using beta-galactosidase.	Adenosine	47-56	galactosidase beta 1	Homo sapiens	63-81
4406193-0	1974	Hydrolysis of lactose in acid whey using beta-galactosidase immobilized on porous glass particles: preparation and characterization of a reusable catalyst for the production of low-lactose dairy products.	Lactose	181-188	galactosidase beta 1	Homo sapiens	41-59
4774399-0	1973	Hydrolysis of GM1-ganglioside by human liver beta-galactosidase isoenzymes.	G(M1) Ganglioside	14-29	galactosidase beta 1	Homo sapiens	45-63
4206908-6	1974	The linked enzyme system, comprising beta-galactosidase immobilized within a nylon tube acting in series with glucose oxidase immobilized in a similar way, was used for the automated determination of lactose.	Lactose	200-207	galactosidase beta 1	Homo sapiens	37-55
4590555-0	1973	Some properties alpha-chymotrypsin and beta-galactosidase supported in polyacrylamide gels.	polyacrylamide	71-85	galactosidase beta 1	Homo sapiens	39-57
4796096-0	1973	Formation of oligosaccharides during beta-galactosidase action on lactose.	Oligosaccharides	13-29	galactosidase beta 1	Homo sapiens	37-55
4796096-0	1973	Formation of oligosaccharides during beta-galactosidase action on lactose.	Lactose	66-73	galactosidase beta 1	Homo sapiens	37-55
4774399-2	1973	GM(1)-ganglioside, specifically tritiated in the terminal galactose, was hydrolysed by two forms of ;acid" methylumbelliferyl beta-galactosidase isolated on gel filtration.	G(M1) Ganglioside	0-17	galactosidase beta 1	Homo sapiens	126-144
4774399-2	1973	GM(1)-ganglioside, specifically tritiated in the terminal galactose, was hydrolysed by two forms of ;acid" methylumbelliferyl beta-galactosidase isolated on gel filtration.	Galactose	58-67	galactosidase beta 1	Homo sapiens	126-144
4774399-4	1973	Identification of GM(1)-ganglioside beta-galactosidase activity with the ;acid" methyl-umbelliferyl beta-galactosidases was based on the following: coincident elution profiles on gel filtration; simultaneous inactivation by heat and other treatments; stabilization of both activities by chloride ions; mutual inhibition of hydrolysis by the two substrates.	G(M1) Ganglioside	18-35	galactosidase beta 1	Homo sapiens	36-54
4747599-0	1973	Antagonistic action of chondroitin sulphate and cetylpyridinium chloride on human liver beta-galactosidase.	Chondroitin Sulfates	23-43	galactosidase beta 1	Homo sapiens	88-106
4774399-4	1973	Identification of GM(1)-ganglioside beta-galactosidase activity with the ;acid" methyl-umbelliferyl beta-galactosidases was based on the following: coincident elution profiles on gel filtration; simultaneous inactivation by heat and other treatments; stabilization of both activities by chloride ions; mutual inhibition of hydrolysis by the two substrates.	Chlorides	287-295	galactosidase beta 1	Homo sapiens	36-54
4747599-0	1973	Antagonistic action of chondroitin sulphate and cetylpyridinium chloride on human liver beta-galactosidase.	Cetylpyridinium	48-72	galactosidase beta 1	Homo sapiens	88-106
4583266-0	1973	Immobilization of beta-galactosidase on an insoluble carrier with a polyisocyanate polymer.	Polyurethanes	68-82	galactosidase beta 1	Homo sapiens	18-36
4590119-0	1973	Effects of alcohols on beta-galactosidase-catalyzed hydrolysis of n-alkyl-beta-D-galactopyranosides.	Alcohols	11-19	galactosidase beta 1	Homo sapiens	23-41
4590119-0	1973	Effects of alcohols on beta-galactosidase-catalyzed hydrolysis of n-alkyl-beta-D-galactopyranosides.	n-alkyl-beta-d-galactopyranosides	66-99	galactosidase beta 1	Homo sapiens	23-41
4583267-0	1973	Immobilization of beta-galactosidase on an insoluble carrier with a polyisocyanate polymer.	Polyurethanes	68-82	galactosidase beta 1	Homo sapiens	18-36
4270231-2	1973	Changes in subcellular distribution of the lysosomal enzymes acid deoxyribonuclease and beta-galactosidase during acute intoxication by diethylnitrosamine].	Diethylnitrosamine	136-154	galactosidase beta 1	Homo sapiens	88-106
4268963-5	1973	After the addition of chondroitin sulfate, the total activity of beta-galactosidase is inhibited, whereas other hydrolases are affected only slightly or not at all.	Chondroitin Sulfates	22-41	galactosidase beta 1	Homo sapiens	65-83
4522795-1	1974	Activity of lactosyl ceramide beta-galactosidase (beta-D-galactoside galactohydrolase, EC 3.2.1.23) was found to be extremely low in enzyme preparations from liver, brain, and cultured skin fibroblasts from patients with Krabbe"s disease.	CDw17 antigen	12-29	galactosidase beta 1	Homo sapiens	30-48
4522795-4	1974	Beta-galactosidase activity toward galactocerebroside, psychosine, and monogalactosyl diglyceride is also low in patients with Krabbe"s disease.	galactocerebroside	35-53	galactosidase beta 1	Homo sapiens	0-18
4522795-4	1974	Beta-galactosidase activity toward galactocerebroside, psychosine, and monogalactosyl diglyceride is also low in patients with Krabbe"s disease.	Psychosine	55-65	galactosidase beta 1	Homo sapiens	0-18
4522795-4	1974	Beta-galactosidase activity toward galactocerebroside, psychosine, and monogalactosyl diglyceride is also low in patients with Krabbe"s disease.	monogalactosyl diglyceride	71-97	galactosidase beta 1	Homo sapiens	0-18
4578762-3	1973	Steady-state kinetic parameters for the beta-galactosidase-catalysed hydrolysis of 13 aryl beta-d-galactopyranosides show no simple dependence on aglycone acidity.	aryl beta-d-galactopyranosides	86-116	galactosidase beta 1	Homo sapiens	40-58
4578762-3	1973	Steady-state kinetic parameters for the beta-galactosidase-catalysed hydrolysis of 13 aryl beta-d-galactopyranosides show no simple dependence on aglycone acidity.	CHEBI:166892	146-154	galactosidase beta 1	Homo sapiens	40-58
4721624-0	1973	The effect of methanol and dioxan on the rates of the beta-galactosidase-catalysed hydrolyses of some beta-D-galactrophyranosides: rate-limiting degalactosylation.	Methanol	14-22	galactosidase beta 1	Homo sapiens	54-72
4721624-0	1973	The effect of methanol and dioxan on the rates of the beta-galactosidase-catalysed hydrolyses of some beta-D-galactrophyranosides: rate-limiting degalactosylation.	1,4-dioxane	27-33	galactosidase beta 1	Homo sapiens	54-72
4621795-4	1972	In cultures without added beta-galactosidase, a low concentration of galactose accumulated in the milk, whereas glucose was not detected after 2 hr of incubation.	Galactose	69-78	galactosidase beta 1	Homo sapiens	26-44
4721624-0	1973	The effect of methanol and dioxan on the rates of the beta-galactosidase-catalysed hydrolyses of some beta-D-galactrophyranosides: rate-limiting degalactosylation.	beta-d-galactrophyranosides	102-129	galactosidase beta 1	Homo sapiens	54-72
4721624-3	1973	The effect of methanol on the beta-galactosidase-catalysed hydrolysis of some nitrophenyl beta-d-galactopyranosides has been studied under steady-state conditions.	Methanol	14-22	galactosidase beta 1	Homo sapiens	30-48
4721624-3	1973	The effect of methanol on the beta-galactosidase-catalysed hydrolysis of some nitrophenyl beta-d-galactopyranosides has been studied under steady-state conditions.	nitrophenyl beta-d-galactopyranosides	78-115	galactosidase beta 1	Homo sapiens	30-48
4721625-0	1973	The role of magnesium ions in beta-galactosidase hydrolyses.	Magnesium	12-21	galactosidase beta 1	Homo sapiens	30-48
4721625-3	1973	beta-d-Galactopyranosyl trimethylammonium bromide is a competitive inhibitor of beta-galactosidase, K(i)=1.4+/-0.2mm at 25 degrees C. 2.	Galactosyltrimethylammonium	0-49	galactosidase beta 1	Homo sapiens	80-98
4724607-0	1973	The immobilization of beta-galactosidase through encapsulation in water-insoluble microcapsules.	Water	66-71	galactosidase beta 1	Homo sapiens	22-40
4278241-0	1973	Purification and properties of a keratan sulfate hydrolyzing enzyme, an endo-beta-galactosidase.	Keratan Sulfate	33-48	galactosidase beta 1	Homo sapiens	77-95
4258708-0	1972	Leukocyte beta-galactosidase activity in the diagnosis of generalized GM 1  gangliosidosis.	G(M1) Ganglioside	70-74	galactosidase beta 1	Homo sapiens	10-28
4198387-0	1973	[On the histochemical and microchemical demonstration of beta-galactosidase by means of 1-naphthyl-beta-galactopyranoside].	1-naphthyl-beta-galactopyranoside	88-121	galactosidase beta 1	Homo sapiens	57-75
4118294-1	1972	The catabolite repression caused by glucose and glucose-6-phosphate has been studied for both beta-galactosidase and thiogalactoside transacetylase, the products of the operator proximal and distal cistrons of the lac operon, respectively.	catabolite	4-14	galactosidase beta 1	Homo sapiens	94-112
4118294-1	1972	The catabolite repression caused by glucose and glucose-6-phosphate has been studied for both beta-galactosidase and thiogalactoside transacetylase, the products of the operator proximal and distal cistrons of the lac operon, respectively.	Glucose	36-43	galactosidase beta 1	Homo sapiens	94-112
4118294-1	1972	The catabolite repression caused by glucose and glucose-6-phosphate has been studied for both beta-galactosidase and thiogalactoside transacetylase, the products of the operator proximal and distal cistrons of the lac operon, respectively.	Glucose-6-Phosphate	48-67	galactosidase beta 1	Homo sapiens	94-112
4621795-7	1972	In addition to providing the culture with a more readily available energy source, it is possible that the culture produced more acidic metabolites as a result of preferentially utilizing the glucose released by the action of the beta-galactosidase.	Glucose	191-198	galactosidase beta 1	Homo sapiens	229-247
4945186-2	1971	Undelayed beta-galactosidase formation was found in stringent auxotrophs recovering from amino acid starvation, in cells recovering from glycerol or potassium starvation, and in bacteria recovering from puromycin treatment.	Potassium	149-158	galactosidase beta 1	Homo sapiens	10-28
4945186-2	1971	Undelayed beta-galactosidase formation was found in stringent auxotrophs recovering from amino acid starvation, in cells recovering from glycerol or potassium starvation, and in bacteria recovering from puromycin treatment.	Glycerol	137-145	galactosidase beta 1	Homo sapiens	10-28
4945186-2	1971	Undelayed beta-galactosidase formation was found in stringent auxotrophs recovering from amino acid starvation, in cells recovering from glycerol or potassium starvation, and in bacteria recovering from puromycin treatment.	Puromycin	203-212	galactosidase beta 1	Homo sapiens	10-28
4945186-3	1971	Delayed beta-galactosidase formation was found in relaxed auxotrophs recovering from amino acid starvation and in prototrophs recovering from chloramphenicol or from tetracycline treatment.	Chloramphenicol	142-157	galactosidase beta 1	Homo sapiens	8-26
4945186-3	1971	Delayed beta-galactosidase formation was found in relaxed auxotrophs recovering from amino acid starvation and in prototrophs recovering from chloramphenicol or from tetracycline treatment.	Tetracycline	166-178	galactosidase beta 1	Homo sapiens	8-26
5117032-7	1971	Separation on a Sephadex G-200 column revealed that the acid beta-galactosidase could occur in at least three different forms, probably representing monomer, dimer and octamer or polymer of the enzyme.	sephadex	16-30	galactosidase beta 1	Homo sapiens	61-79
5117032-9	1971	The properties of the different forms of the acid beta-galactosidase were studied with regard to pH optimum, K(m), rate of hydrolysis of different substrates, and sensitivity to p-chloromercuribenzoate and tris as inhibitors.	p-chloromercuribenzoate	178-201	galactosidase beta 1	Homo sapiens	50-68
5117032-9	1971	The properties of the different forms of the acid beta-galactosidase were studied with regard to pH optimum, K(m), rate of hydrolysis of different substrates, and sensitivity to p-chloromercuribenzoate and tris as inhibitors.	Tromethamine	206-210	galactosidase beta 1	Homo sapiens	50-68
5117032-12	1971	The acid beta-galactosidase hydrolyses lactose as well as hetero beta-galactosides and contributes to the lactase activity of intestinal biopsies also when measured at pH 6.	Lactose	39-46	galactosidase beta 1	Homo sapiens	9-27
5117032-12	1971	The acid beta-galactosidase hydrolyses lactose as well as hetero beta-galactosides and contributes to the lactase activity of intestinal biopsies also when measured at pH 6.	hetero beta-galactosides	58-82	galactosidase beta 1	Homo sapiens	9-27
4991355-0	1970	[Decoupled induction of "lactose" messenger RNA by an anti-inductor agnent of beta-galactosidase].	Lactose	25-32	galactosidase beta 1	Homo sapiens	78-96
4911377-0	1970	Studies on the interaction of the inhibitor o-mercuriphenyl beta-D-galactoside chloride with beta-galactosidase from Escherichiacoli K 12.	o-mercuriphenyl beta-d-galactoside chloride	44-87	galactosidase beta 1	Homo sapiens	93-111
4919959-0	1970	Beta-galactosidase: alpha-complementation of a deletion mutant with cyanogen bromide peptides.	Cyanogen Bromide	68-84	galactosidase beta 1	Homo sapiens	0-18
4910384-0	1970	The non-simultaneous dissociation and loss of activity of beta-galactosidase in urea.	Urea	80-84	galactosidase beta 1	Homo sapiens	58-76
4893080-0	1969	The stability of beta galactosidase in the presence of urea.	Urea	55-59	galactosidase beta 1	Homo sapiens	17-35
11945805-0	1971	Labelling of the active site of beta-galactosidase by N-bromoacetyl beta-D-galactopyranosylamine.	n-bromoacetyl beta-d-galactopyranosylamine	54-96	galactosidase beta 1	Homo sapiens	32-50
4927396-0	1970	Effect of factor C on glucose repression of induced beta-galactosidase synthesis.	Glucose	22-29	galactosidase beta 1	Homo sapiens	52-70
4900984-0	1969	Evidence for pyrrolidone carboxylic acid in beta-galactosidase from E.	Pyrrolidonecarboxylic Acid	13-40	galactosidase beta 1	Homo sapiens	44-62
5821405-0	1969	The kinetics of beta-galactosidase attached to porous cellulose sheets.	Cellulose	54-63	galactosidase beta 1	Homo sapiens	16-34
4303478-0	1968	The role of the lac promotor locus in the regulation of beta-galactosidase synthesis by cyclic 3",5"-adenosine monophosphate.	cyclic 3",5"-adenosine monophosphate	88-124	galactosidase beta 1	Homo sapiens	56-74
4883493-0	1969	The effect of ethionine on the synthesis of beta galactosidase: formation of an immunologically cross-reacting protein.	Ethionine	14-23	galactosidase beta 1	Homo sapiens	44-62
4888281-0	1969	Effect of alcohols on the enzymatic activity and subunit association of beta-galactosidase.	Alcohols	10-18	galactosidase beta 1	Homo sapiens	72-90
4981101-0	1969	[Sucrose density gradient centrifugation fractionation of an E coli particulate preparation induced to synthesize beta-galactosidase].	Sucrose	1-8	galactosidase beta 1	Homo sapiens	114-132
5647842-1	1968	A profound deficiency (10- to 30-fold) of beta-galactosidase activity was found in tissues (liver, spleen, kidney, and brain) from two patients with generalized gangliosidosis; this deficiency is demonstrated as a failure to cleave both p-nitrophenyl-beta-D-galactopyranoside and ganglioside GM(1) labeled with C(14) in the terminal galactose.	4-nitrophenylgalactoside	237-275	galactosidase beta 1	Homo sapiens	42-60
5672844-0	1968	Identity of beta-glucosidase, beta-xylosidase and one of the beta-galactosidase activities in human liver when assayed with 4-methylumbelliferyl-beta-D-glycosides studies in cases of Gaucher"s disease.	4-methylumbelliferyl-beta-d-glycosides	124-162	galactosidase beta 1	Homo sapiens	61-79
5647842-1	1968	A profound deficiency (10- to 30-fold) of beta-galactosidase activity was found in tissues (liver, spleen, kidney, and brain) from two patients with generalized gangliosidosis; this deficiency is demonstrated as a failure to cleave both p-nitrophenyl-beta-D-galactopyranoside and ganglioside GM(1) labeled with C(14) in the terminal galactose.	ganglioside gm	280-294	galactosidase beta 1	Homo sapiens	42-60
5647842-1	1968	A profound deficiency (10- to 30-fold) of beta-galactosidase activity was found in tissues (liver, spleen, kidney, and brain) from two patients with generalized gangliosidosis; this deficiency is demonstrated as a failure to cleave both p-nitrophenyl-beta-D-galactopyranoside and ganglioside GM(1) labeled with C(14) in the terminal galactose.	Galactose	333-342	galactosidase beta 1	Homo sapiens	42-60
4860414-0	1967	Synergistic activation of beta-galactosidase by Na and Cs.	Cesium	55-57	galactosidase beta 1	Homo sapiens	26-44
4382321-0	1967	Metabolite-promoted heat lability of beta-galactosidase and its relation to catabolite repression.	catabolite	76-86	galactosidase beta 1	Homo sapiens	37-55
4871031-2	1968	Effects of methyl-beta-D-thiogalactopyranoside and phenethyl alcohol on induced and repressed beta-galactosidase systems.	thiomethylgalactoside	11-46	galactosidase beta 1	Homo sapiens	94-112
4871031-2	1968	Effects of methyl-beta-D-thiogalactopyranoside and phenethyl alcohol on induced and repressed beta-galactosidase systems.	Phenylethyl Alcohol	51-68	galactosidase beta 1	Homo sapiens	94-112
5326545-0	1965	Enhancement of catabolite repression by mitomycin C in the induced synthesis of beta-galactosidase.	catabolite	15-25	galactosidase beta 1	Homo sapiens	80-98
4958494-1	1966	Many nonsense mutants that map in the beta-galactosidase structural gene produce material that forms precipitin lines when tested by double diffusion on agar against antiserum prepared from native beta-galactosidase.	Agar	153-157	galactosidase beta 1	Homo sapiens	38-56
5949569-2	1966	The presence of beta-galactosidase (EC 3.2.1.23) in an acetic acid extract of ram testis is reported.	Acetic Acid	55-66	galactosidase beta 1	Homo sapiens	16-34
5949569-5	1966	The purification of beta-acetylglucosaminase (EC 3.2.1.30) and of beta-galactosidase from the ram-testis extract by ammonium sulphate precipitation and chromatography on a CM-cellulose column is described.	Ammonium Sulfate	116-133	galactosidase beta 1	Homo sapiens	66-84
5338572-0	1966	Heat denaturation of beta-galactosidase: a possible approach to the problem of catabolite repression and its site of action.	catabolite	79-89	galactosidase beta 1	Homo sapiens	21-39
5335384-1	1966	Detection of beta-galactosidase with the aid of o-nitrophenyl-beta-d-galactopyranoside (ONPG) was examined as a means for distinguishing between Citrobacter and Salmonella.	2-nitrophenylgalactoside	48-86	galactosidase beta 1	Homo sapiens	13-31
5326545-0	1965	Enhancement of catabolite repression by mitomycin C in the induced synthesis of beta-galactosidase.	Mitomycin	40-51	galactosidase beta 1	Homo sapiens	80-98
14062647-0	1963	A STUDY OF THE UREA-PRODUCED SUBUNITS OF BETA-GALACTOSIDASE.	Urea	15-19	galactosidase beta 1	Homo sapiens	41-59
14300753-0	1965	CARBOXYPEPTIDASE STUDIES ON BETA-GALACTOSIDASE: DETECTION OF ONE C-TERMINAL LYSINE PER MONOMER.	Lysine	76-82	galactosidase beta 1	Homo sapiens	28-46
14186909-0	1964	[DIFFERENCES EXISTING BETWEEN THE PROPERTIES OF NORMAL BETA-GALACTOSIDASE AND THOSE OF BETA-GALACTOSIDASE IN WHICH THE TYROSINE GROUPS ARE REPLACED BY 3-FLUOROTYROSINE].	3-fluorotyrosine	151-167	galactosidase beta 1	Homo sapiens	55-73
13953707-0	1962	Differential inhibition of beta-galactosidase induction and synthesis by deuterium oxide.	Deuterium Oxide	73-88	galactosidase beta 1	Homo sapiens	27-45
33937931-10	2021	The beta-galactosidase from Bacillus licheniformis immobilized in Duolite A568 is a promising technique to produce reduced or lactose-free dairy products, as it allows reuse of the biocatalyst, decreasing operational costs.Key Points  Immobilization of beta-galactosidase from Bacillus licheniformis in batch reactor  Influence of buffer pH and ionic concentration and offered enzyme activity on immobilization  Influence of glutaraldehyde on operational stability.	Lactose	126-133	galactosidase beta 1	Homo sapiens	4-22
13729467-0	1961	An ultrasensitive assay of beta-galactosidase with C14-labeled o-nitrophenyl-beta-D-galactoside.	2-nitrophenylgalactoside	63-95	galactosidase beta 1	Homo sapiens	27-45
33774147-6	2021	METHODS: beta-Galactosidase was immobilized by physical adsorption on halloysite, an aluminosilicate nanomaterial.	aluminosilicate	85-100	galactosidase beta 1	Homo sapiens	9-27
33246685-0	2021	Anion carboxymethylated beta-glucan alleviates undesirable binding between procyanidins and beta-galactosidase.	anion carboxymethylated beta-glucan	0-35	galactosidase beta 1	Homo sapiens	92-110
33246685-0	2021	Anion carboxymethylated beta-glucan alleviates undesirable binding between procyanidins and beta-galactosidase.	Proanthocyanidins	75-87	galactosidase beta 1	Homo sapiens	92-110
33246685-1	2021	To solve the potential problem of hindered beta-galactosidase activity by procyanidins, carboxymethylated Pachyman (CMP), a negatively-charged carboxymethylated (1   3)-beta-d-glucan, was applied to mitigate inhibition by procyanidins.	Proanthocyanidins	74-86	galactosidase beta 1	Homo sapiens	43-61
33246685-1	2021	To solve the potential problem of hindered beta-galactosidase activity by procyanidins, carboxymethylated Pachyman (CMP), a negatively-charged carboxymethylated (1   3)-beta-d-glucan, was applied to mitigate inhibition by procyanidins.	carboxymethylated pachyman	88-114	galactosidase beta 1	Homo sapiens	43-61
33246685-4	2021	The competitive/noncompetitive inhibition constants, fluorescence quenching constants, and molecular docking results indicated that the mechanism of this effect might be CMP competing with beta-galactosidase to bind procyanidins, resulting in restoration of the catalytic centre and key active site of procyanidin-bound lactase.	Proanthocyanidins	216-228	galactosidase beta 1	Homo sapiens	189-207
14098355-0	1963	A COMPARATIVE STUDY OF A SERIES OF NEW INDOLYL  COMPOUNDS TO LOCALIZE BETA-GALACTOSIDASE IN TISSUES.	indolyl	39-46	galactosidase beta 1	Homo sapiens	70-88
33937931-10	2021	The beta-galactosidase from Bacillus licheniformis immobilized in Duolite A568 is a promising technique to produce reduced or lactose-free dairy products, as it allows reuse of the biocatalyst, decreasing operational costs.Key Points  Immobilization of beta-galactosidase from Bacillus licheniformis in batch reactor  Influence of buffer pH and ionic concentration and offered enzyme activity on immobilization  Influence of glutaraldehyde on operational stability.	Glutaral	425-439	galactosidase beta 1	Homo sapiens	4-22
33448121-5	2021	The enzyme beta-galactosidase (beta-Gal) is efficiently entrapped into phase-separated coacervates of ureido polymers upon cooling.	ureido polymers	102-117	galactosidase beta 1	Homo sapiens	11-29
24156116-0	1993	GLB1-Related Disorders CLINICAL CHARACTERISTICS: GLB1-related disorders comprise two phenotypically distinct lysosomal storage disorders: GM1 gangliosidosis and mucopolysaccharidosis type IVB (MPS IVB).	G(M1) Ganglioside	138-141	galactosidase beta 1	Homo sapiens	0-4
24156116-0	1993	GLB1-Related Disorders CLINICAL CHARACTERISTICS: GLB1-related disorders comprise two phenotypically distinct lysosomal storage disorders: GM1 gangliosidosis and mucopolysaccharidosis type IVB (MPS IVB).	G(M1) Ganglioside	138-141	galactosidase beta 1	Homo sapiens	49-53
33687404-2	2021	The 3-O-sulfo-beta-galactose linker is cleaved sequentially by two lysosomal enzymes - arylsulfatase A and beta-galactosidase - to release the payload in targeted cells.	3-o-sulfo-beta-galactose	4-28	galactosidase beta 1	Homo sapiens	107-125
33859490-2	2021	Mutation of the GLB1 gene, which codes for beta-gal, prevents cleavage of the terminal beta-1,4-linked galactose residue from GM1 ganglioside.	1,4-linked galactose	92-112	galactosidase beta 1	Homo sapiens	16-20
33859490-2	2021	Mutation of the GLB1 gene, which codes for beta-gal, prevents cleavage of the terminal beta-1,4-linked galactose residue from GM1 ganglioside.	G(M1) Ganglioside	126-141	galactosidase beta 1	Homo sapiens	16-20
33736637-10	2021	A full biochemical characterization of the recombinant beta-galactosidase has been carried out and the ability of this enzyme to perform homo- and hetero-condensation reactions to produce galacto-oligosaccharides, has been demonstrated.	galacto-oligosaccharides	188-212	galactosidase beta 1	Homo sapiens	55-73
33656174-5	2022	beta-galactosidase is employed by many food industries to degrade lactose and improve the digestibility, sweetness, solubility and flavor of dairy products.	Lactose	66-73	galactosidase beta 1	Homo sapiens	0-18
33656174-6	2022	beta-Galactosidase enzymes have various families and are applied in the food processing industries such as hydrolyzed-milk products, whey, and galacto-oligosaccharides.	galacto-oligosaccharides	143-167	galactosidase beta 1	Homo sapiens	0-18
32871299-1	2021	In this work, one kind of zeolite imidazole frameworks containing bovine serum albumin stabilized Au nanoclusters (AuNCs), beta-galactosidase (beta-Gal) and glucose oxidase (GOx) (AuNCs/beta-Gal/GOx@ZIF-8) were obtained to detect lactose.	imidazole	34-43	galactosidase beta 1	Homo sapiens	123-141
33606064-1	2021	beta-Galactosidase (beta-Gal) is a widely used enzyme as a reporter gene in the field of molecular biology which hydrolyzes the beta-galactosides into monosaccharides.	beta-galactoside	128-145	galactosidase beta 1	Homo sapiens	0-18
33606064-1	2021	beta-Galactosidase (beta-Gal) is a widely used enzyme as a reporter gene in the field of molecular biology which hydrolyzes the beta-galactosides into monosaccharides.	Monosaccharides	151-166	galactosidase beta 1	Homo sapiens	0-18
33668968-0	2021	Stabilization of beta-Galactosidase on Modified Gold Nanoparticles: A Preliminary Biochemical Study to Obtain Lactose-Free Dairy Products for Lactose-Intolerant Individuals.	Lactose	110-117	galactosidase beta 1	Homo sapiens	17-35
33668968-0	2021	Stabilization of beta-Galactosidase on Modified Gold Nanoparticles: A Preliminary Biochemical Study to Obtain Lactose-Free Dairy Products for Lactose-Intolerant Individuals.	Lactose	142-149	galactosidase beta 1	Homo sapiens	17-35
33450376-7	2021	The addition of HNE and ONE (4-oxo-2-nonenal), to cultured HTR-8/SVneo human trophoblasts activated the senescence-activated beta-galactosidase, and generated an accumulation of acetylated proteins, consistent with a modification of SIRT1 by HNE.	2-nonenal	35-44	galactosidase beta 1	Homo sapiens	125-143
33437209-7	2021	Furthermore, p-cresol and indoxyl sulfate gradually increased senescence-associated beta-galactosidase positive cells while upregulated the expression of p21 which participate in senescent process.	4-cresol	13-21	galactosidase beta 1	Homo sapiens	84-102
33562281-5	2021	Moreover, exogenous NAD+ reduced senescence-associated-beta-galactosidase activity, and downregulated poly (ADP-ribose) polymerase 1 expression.	NAD	20-24	galactosidase beta 1	Homo sapiens	55-73
33529089-5	2021	Among the 10 resveratrol analogues, Pts and Pts nicotinate attenuated the expression of senescence-associated beta-galactosidase, downregulated p21 and p53, and increased the production of NO in both angiotensin II and H2O2-induced endothelial senescence models.	Resveratrol	13-24	galactosidase beta 1	Homo sapiens	110-128
33529089-5	2021	Among the 10 resveratrol analogues, Pts and Pts nicotinate attenuated the expression of senescence-associated beta-galactosidase, downregulated p21 and p53, and increased the production of NO in both angiotensin II and H2O2-induced endothelial senescence models.	Niacin	48-58	galactosidase beta 1	Homo sapiens	110-128
33128213-5	2021	We observed increased percentage of cells with increased SA-beta-galactosidase activity, decreased cell viability/proliferation and increased level of p21 in both models.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	57-59	galactosidase beta 1	Homo sapiens	60-78
32813504-3	2021	In this work, we fabricated boronic ester-based dynamic covalent hydrogels for the encapsulation and in vitro release of a model biologic (beta-galactosidase).	boronic ester	28-41	galactosidase beta 1	Homo sapiens	139-157
33437209-7	2021	Furthermore, p-cresol and indoxyl sulfate gradually increased senescence-associated beta-galactosidase positive cells while upregulated the expression of p21 which participate in senescent process.	Indican	26-41	galactosidase beta 1	Homo sapiens	84-102
33320602-1	2020	A dual-enzyme metal-organic hybrid crystal was constructed through self-assembling of manganese phosphate embedded with beta-galactosidase and L-arabinose isomerase for facile synthesis of rare sugar D-tagatose.	Metals	14-19	galactosidase beta 1	Homo sapiens	120-138
33320602-1	2020	A dual-enzyme metal-organic hybrid crystal was constructed through self-assembling of manganese phosphate embedded with beta-galactosidase and L-arabinose isomerase for facile synthesis of rare sugar D-tagatose.	manganese phosphate	86-105	galactosidase beta 1	Homo sapiens	120-138
33320602-1	2020	A dual-enzyme metal-organic hybrid crystal was constructed through self-assembling of manganese phosphate embedded with beta-galactosidase and L-arabinose isomerase for facile synthesis of rare sugar D-tagatose.	sugar d-tagatose	194-210	galactosidase beta 1	Homo sapiens	120-138
32563033-0	2020	Facile and label-free fluorescence sensing of beta-galactosidase activity by graphene quantum dots.	Graphite	77-85	galactosidase beta 1	Homo sapiens	46-64
33052367-0	2020	Far-red imaging of beta-galactosidase through a phospha-fluorescein.	phospha-fluorescein	48-67	galactosidase beta 1	Homo sapiens	19-37
33052367-3	2020	Probe DiMe-PF-Gal without further structural decoration was designed for accurately monitoring beta-galactosidase in vivo.	dime-pf-gal	6-17	galactosidase beta 1	Homo sapiens	95-113
33274583-4	2020	In vitro, cyanidin-3-rutinoside (C-3-R) and cyanidin-3-glucoside (C-3-G) inhibited the d-galactose (d-gal)-induced senescence in human endothelial cells, as indicated by reduced senescence-associated-beta-galactosidase activity, p21, and p16INK4a .	cyanidin 3-rutinoside	10-31	galactosidase beta 1	Homo sapiens	200-218
33274583-4	2020	In vitro, cyanidin-3-rutinoside (C-3-R) and cyanidin-3-glucoside (C-3-G) inhibited the d-galactose (d-gal)-induced senescence in human endothelial cells, as indicated by reduced senescence-associated-beta-galactosidase activity, p21, and p16INK4a .	cyanidin-3-o-glucoside	44-64	galactosidase beta 1	Homo sapiens	200-218
33274583-4	2020	In vitro, cyanidin-3-rutinoside (C-3-R) and cyanidin-3-glucoside (C-3-G) inhibited the d-galactose (d-gal)-induced senescence in human endothelial cells, as indicated by reduced senescence-associated-beta-galactosidase activity, p21, and p16INK4a .	cyanidin-3-o-glucoside	66-71	galactosidase beta 1	Homo sapiens	200-218
33274583-4	2020	In vitro, cyanidin-3-rutinoside (C-3-R) and cyanidin-3-glucoside (C-3-G) inhibited the d-galactose (d-gal)-induced senescence in human endothelial cells, as indicated by reduced senescence-associated-beta-galactosidase activity, p21, and p16INK4a .	Galactose	87-98	galactosidase beta 1	Homo sapiens	200-218
33274583-4	2020	In vitro, cyanidin-3-rutinoside (C-3-R) and cyanidin-3-glucoside (C-3-G) inhibited the d-galactose (d-gal)-induced senescence in human endothelial cells, as indicated by reduced senescence-associated-beta-galactosidase activity, p21, and p16INK4a .	Galactose	87-92	galactosidase beta 1	Homo sapiens	200-218
32997490-5	2020	In the cytosol, endogenous small peptides and amino acids with relatively high charge densities, such as glutathione, trigger NP disassembly through competitive supramolecular interactions, thereby releasing functional bioactive proteins, as validated using cytochrome C and beta-galactosidase.	Peptides	33-41	galactosidase beta 1	Homo sapiens	275-293
32997490-5	2020	In the cytosol, endogenous small peptides and amino acids with relatively high charge densities, such as glutathione, trigger NP disassembly through competitive supramolecular interactions, thereby releasing functional bioactive proteins, as validated using cytochrome C and beta-galactosidase.	Glutathione	105-116	galactosidase beta 1	Homo sapiens	275-293
32993878-2	2020	Probe FR-2a integrated water-soluble fluorophore (HT-4a) and beta-galactosidase (beta-gal) trigger into one entity by a p-hydroxybenzyl quaternary ammonium linker.	p-hydroxybenzyl quaternary ammonium	120-155	galactosidase beta 1	Homo sapiens	61-79
31481471-1	2020	Autosomal recessive mutations in the galactosidase beta1 (GLB1) gene cause lysosomal beta-gal deficiency, resulting in accumulation of galactose-containing substrates and onset of the progressive and fatal neurodegenerative lysosomal storage disease, GM1 gangliosidosis.	Galactose	135-144	galactosidase beta 1	Homo sapiens	37-56
32779865-1	2020	BACKGROUND: In GM1 gangliosidosis the lack of function of beta-galactosidase results in an accumulation of GM1 ganglioside and related glycoconjugates in visceral organs, and particularly in the central nervous system, leading to severe disability and premature death.	G(M1) Ganglioside	15-18	galactosidase beta 1	Homo sapiens	58-76
32779865-1	2020	BACKGROUND: In GM1 gangliosidosis the lack of function of beta-galactosidase results in an accumulation of GM1 ganglioside and related glycoconjugates in visceral organs, and particularly in the central nervous system, leading to severe disability and premature death.	G(M1) Ganglioside	107-122	galactosidase beta 1	Homo sapiens	58-76
32278244-2	2020	In this work, as well as studying the effect of ultrasound (US) on glucose oxidase (Gox) activation during gluconic acid (GA) production, we have carried out an investigation into the selective oxidation of glucose to gluconic acid in multienzymatic reactions (beta-galactosidase (beta-gal) and Gox) assisted by power US using different sources of lactose as substrate (lactose solution, whey permeate, cheese whey).	gluconic acid	218-231	galactosidase beta 1	Homo sapiens	261-279
31481471-1	2020	Autosomal recessive mutations in the galactosidase beta1 (GLB1) gene cause lysosomal beta-gal deficiency, resulting in accumulation of galactose-containing substrates and onset of the progressive and fatal neurodegenerative lysosomal storage disease, GM1 gangliosidosis.	Galactose	135-144	galactosidase beta 1	Homo sapiens	58-62
32657300-2	2020	These precursors, comprising galactose sensitive units at both polar heads, showed the formation of hydrogels upon the action of beta-galactosidase.	Galactose	29-38	galactosidase beta 1	Homo sapiens	129-147
32629071-9	2020	SLNs containing metformin showed anti-senescence effects on UVB-induced senescence of human dermal fibroblasts, this effect was confirmed by senescence-associated beta-galactosidase staining, RT q-PCR and cell cycle analyses.	Metformin	16-25	galactosidase beta 1	Homo sapiens	163-181
32335492-2	2020	beta-Galactosidase formulations can be added to infant milks prior to feeding to reduce the level of lactose and to avoid symptoms of lactose intolerance.	Lactose	101-108	galactosidase beta 1	Homo sapiens	0-18
32335492-2	2020	beta-Galactosidase formulations can be added to infant milks prior to feeding to reduce the level of lactose and to avoid symptoms of lactose intolerance.	Lactose	134-141	galactosidase beta 1	Homo sapiens	0-18
32538077-5	2020	Upon removal of the galactosyl group in MUGF by beta-galactosidase labeling of the target cell surface proteins, the resulting product containing the quinone methide group was found to be both cell-membrane-permeable and reactive with intracellular nucleophiles, thereby providing fluorescent adducts.	quinone	150-157	galactosidase beta 1	Homo sapiens	48-66
32305635-1	2020	OBJECTIVE: lacZ encodes for beta-galactosidase within the galactose operon of bacterial cells.	Galactose	58-67	galactosidase beta 1	Homo sapiens	28-46
32335158-1	2020	The aggregation behavior of two model proteins- i) bovine serum albumin (BSA) and ii) beta-galactosidase (beta-gal), was investigated by micro-flow imaging (MFI) during freeze-thaw cycling in phosphate buffered solutions.	phosphate buffered	192-210	galactosidase beta 1	Homo sapiens	86-104
32068065-4	2020	The results demonstrated that, in comparison to the control Anxi persimmons, the Anxi persimmons treated with 1.35 muL/L 1-MCP manifested higher fruit firmness, higher contents of protopectin, cellulose, and hemicellulose, but a lower level of water-soluble pectin, lower activities of pectin methylesterase, polygalacturonase, cellulase, and beta-galactosidase in Anxi persimmons during postharvest storage.	1-methylcyclopropene	121-126	galactosidase beta 1	Homo sapiens	286-361
32695819-5	2020	Moreover, compared with the H2O2-induced damage group, the WHT treatment group can significantly increase the viability of cells and decrease the ratio of senescence-associated beta-galactosidase-positive cells, intracellular malondialdehyde levels, and the percentage of G1 phase.	wht	59-62	galactosidase beta 1	Homo sapiens	177-195
31792920-6	2020	RESULTS: High glucose (60 mM) significantly decreased cellular viability and increased reactive oxygen species and cellular senescence through the reduction of senescence-associated beta-galactosidase activity.	Glucose	14-21	galactosidase beta 1	Homo sapiens	182-200
32219518-0	2020	The pharmacological chaperone N-n-butyl-deoxygalactonojirimycin enhances beta-galactosidase processing and activity in fibroblasts of a patient with infantile GM1-gangliosidosis.	n-n-butyl-deoxygalactonojirimycin	30-63	galactosidase beta 1	Homo sapiens	73-91
32179165-5	2020	Our results show that Uro-A (but not Uro-C, IsoUro-A, or Uro-B) leads to a dose-dependent anti-clonogenic effect through the increase of the senescence-associated beta-galactosidase activity, rather than by reversible cell cycle arrest and(or) apoptosis which require much higher concentrations.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	22-27	galactosidase beta 1	Homo sapiens	163-181
32267306-0	2020	beta-galactosidase Encapsulated in Carrageenan, Pectin and Carrageenan/Pectin: Comparative Study, Stability and Controlled Release.	Carrageenan	35-46	galactosidase beta 1	Homo sapiens	0-18
32326017-7	2020	The ratio was determined via enzymatic hydrolysis of the lactose moieties using beta-galactosidase and the subsequent detection of the released galactose.	Lactose	57-64	galactosidase beta 1	Homo sapiens	80-98
32355541-10	2020	Senescence-associated beta-galactosidase (beta-Gal) levels were higher in cisplatin-resistant ovarian cancer cells as compared with cisplatin-sensitive ovarian cancer cells.	Cisplatin	74-83	galactosidase beta 1	Homo sapiens	22-40
32355541-10	2020	Senescence-associated beta-galactosidase (beta-Gal) levels were higher in cisplatin-resistant ovarian cancer cells as compared with cisplatin-sensitive ovarian cancer cells.	Cisplatin	132-141	galactosidase beta 1	Homo sapiens	22-40
32549919-4	2020	beta-Galactosidase (beta-Gal) was used to label hCG beta and can catalyze the conversion of nonfluorescent substrate fluorescein di-beta-d-galactopyranoside to produce fluorescein to amplify the signal strength.	fluorescein-digalactoside	117-156	galactosidase beta 1	Homo sapiens	0-18
32549919-4	2020	beta-Galactosidase (beta-Gal) was used to label hCG beta and can catalyze the conversion of nonfluorescent substrate fluorescein di-beta-d-galactopyranoside to produce fluorescein to amplify the signal strength.	Fluorescein	117-128	galactosidase beta 1	Homo sapiens	0-18
32267306-1	2020	The present study investigated the encapsulation of beta-galactosidase in carrageenan, pectin and its hybrid hydrogels by using the ionotropic gelation method.	Carrageenan	74-85	galactosidase beta 1	Homo sapiens	52-70
32267306-8	2020	Carrageenan and pectin hydrogels were 2.0 and 2.4 times more efficiently than commercial tablet in the releasing beta-galactosidase under in vitro conditions, respectively.	Carrageenan	0-11	galactosidase beta 1	Homo sapiens	113-131
32267306-9	2020	The results suggest that pectin and carrageenan hydrogels may be useful for the development of new formulation of beta-galactosidase.	Carrageenan	36-47	galactosidase beta 1	Homo sapiens	114-132
32014016-7	2020	Treatment with AICAR or NAM led to decreased expression of beta-galactosidase, reduced accumulation of dysfunctional lysosomes, and characteristic morphologic features of young MSCs.	AICA ribonucleotide	15-20	galactosidase beta 1	Homo sapiens	59-77
32041778-9	2020	STUB1 expression attenuates hydrogen peroxide-induced cell senescence, indicated by a reduced signal in senescence-associated beta-galactosidase staining and decreased protein levels of two cell senescence markers, p53 and p21.	Hydrogen Peroxide	28-45	galactosidase beta 1	Homo sapiens	126-144
31828913-4	2020	One of the scaffolds made of 2-pyrimidinecarbonitrile and cysteine joined by a benzyl linker was applied to design fluorescent probes to image caspase-3/7  and beta-galactosidase activity in live cells.	4-amino-5-pyrimidinecarbonitrile	29-53	galactosidase beta 1	Homo sapiens	160-178
31828913-4	2020	One of the scaffolds made of 2-pyrimidinecarbonitrile and cysteine joined by a benzyl linker was applied to design fluorescent probes to image caspase-3/7  and beta-galactosidase activity in live cells.	Cysteine	58-66	galactosidase beta 1	Homo sapiens	160-178
31828913-4	2020	One of the scaffolds made of 2-pyrimidinecarbonitrile and cysteine joined by a benzyl linker was applied to design fluorescent probes to image caspase-3/7  and beta-galactosidase activity in live cells.	benzyl 2,3,4-tri-O-benzylglucopyranoside	79-85	galactosidase beta 1	Homo sapiens	160-178
32066852-5	2020	The hydrolysis of lactose over beta-galactosidase converted 95.77 +- 0.67% of lactose into glucose and galactose.	Lactose	18-25	galactosidase beta 1	Homo sapiens	31-49
32066852-5	2020	The hydrolysis of lactose over beta-galactosidase converted 95.77 +- 0.67% of lactose into glucose and galactose.	Lactose	78-85	galactosidase beta 1	Homo sapiens	31-49
32066852-5	2020	The hydrolysis of lactose over beta-galactosidase converted 95.77 +- 0.67% of lactose into glucose and galactose.	Glucose	91-98	galactosidase beta 1	Homo sapiens	31-49
32066852-5	2020	The hydrolysis of lactose over beta-galactosidase converted 95.77 +- 0.67% of lactose into glucose and galactose.	Galactose	103-112	galactosidase beta 1	Homo sapiens	31-49
31606677-0	2020	Immobilization of beta-galactosidase on tannic acid stabilized silver nanoparticles: A safer way towards its industrial application.	Tannins	40-51	galactosidase beta 1	Homo sapiens	18-36
31606677-0	2020	Immobilization of beta-galactosidase on tannic acid stabilized silver nanoparticles: A safer way towards its industrial application.	Silver	63-69	galactosidase beta 1	Homo sapiens	18-36
31606677-1	2020	In this study, beta-galactosidase has been immobilized on tannic acid stabilized silver nanoparticles (AgNPs).	Tannins	58-69	galactosidase beta 1	Homo sapiens	15-33
31606677-1	2020	In this study, beta-galactosidase has been immobilized on tannic acid stabilized silver nanoparticles (AgNPs).	Silver	81-87	galactosidase beta 1	Homo sapiens	15-33
31606677-5	2020	beta-galactosidase immobilized on tannic acid stabilized AgNPs (83.6% Immobilization yield) exhibited good activity with a high enzyme to carrier ratio as compared to the previous reports.	Tannins	34-45	galactosidase beta 1	Homo sapiens	0-18
31606677-10	2020	beta-galactosidase immobilized on tannic acid stabilized AgNPs are free from toxicity hazards of the linker molecules.	Tannins	34-45	galactosidase beta 1	Homo sapiens	0-18
31806373-7	2020	Senescence-associated beta-galactosidase activity increased in human dermal fibroblasts cultured in a high glucose environment, but SP inhibited the beta-galactosidase activity of the fibroblasts.	Glucose	107-114	galactosidase beta 1	Homo sapiens	22-40
32014016-7	2020	Treatment with AICAR or NAM led to decreased expression of beta-galactosidase, reduced accumulation of dysfunctional lysosomes, and characteristic morphologic features of young MSCs.	Niacinamide	24-27	galactosidase beta 1	Homo sapiens	59-77
31670609-6	2020	Therefore, the 63rd residue was found to be significant for the prenyl-substrate preference.Abbreviations: GPP: geranyl diphosphate; FPP: farnesyl diphosphate; IPP: isopentenyl diphosphate; GGPP: geranylgeranyl diphosphate; FARM: first aspartate-rich motif; SARM: second aspartate-rich motif; beta-Gal: beta-galactosidase; TBABG: tryptose blood agar base supplemented with glucose; X-gal: 5-bromo-4-chloro-3-indolyl-beta-D-galactoside.	prenyl	64-70	galactosidase beta 1	Homo sapiens	303-321
31494342-2	2020	The main application of beta-galactosidase is related to the production of low-lactose and lactose-free milk and dairy products, which are now common consumer goods in supermarket shelves.	Lactose	79-86	galactosidase beta 1	Homo sapiens	24-42
31566298-6	2020	Furthermore, aging markers such as senescence-associated beta-galactosidase p53, p21Cip1/WAF1 , and p16INK4A were upregulated under H2 O2 exposure and galangin could reverse its effects.	Water	132-137	galactosidase beta 1	Homo sapiens	57-75
31566298-6	2020	Furthermore, aging markers such as senescence-associated beta-galactosidase p53, p21Cip1/WAF1 , and p16INK4A were upregulated under H2 O2 exposure and galangin could reverse its effects.	galangin	151-159	galactosidase beta 1	Homo sapiens	57-75
31494342-2	2020	The main application of beta-galactosidase is related to the production of low-lactose and lactose-free milk and dairy products, which are now common consumer goods in supermarket shelves.	Lactose	91-98	galactosidase beta 1	Homo sapiens	24-42
31494342-7	2020	This article reviews the main applications of beta-galactosidase, going from its conventional use related to its hydrolytic activity to the ongoing non-conventional applications in the synthesis of high added-value oligosaccharides based on its transgalactosylation activity.	Oligosaccharides	215-231	galactosidase beta 1	Homo sapiens	46-64
31746354-6	2020	The present study demonstrated that Hnk was able to prevent Dox-induced senescence of H9c2 cardiomyocytes, indicated by decreased senescence-associated beta-galactosidase (SA-beta-gal) staining, as well as decreased expression of p16INK4A and p21.	honokiol	36-39	galactosidase beta 1	Homo sapiens	152-170
31746354-6	2020	The present study demonstrated that Hnk was able to prevent Dox-induced senescence of H9c2 cardiomyocytes, indicated by decreased senescence-associated beta-galactosidase (SA-beta-gal) staining, as well as decreased expression of p16INK4A and p21.	Doxorubicin	60-63	galactosidase beta 1	Homo sapiens	152-170
31908576-5	2020	In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways.	Hydrogen Peroxide	19-36	galactosidase beta 1	Homo sapiens	150-168
31908576-5	2020	In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways.	Water	38-42	galactosidase beta 1	Homo sapiens	150-168
31563443-8	2019	Using the developed setup, we demonstrated the dependency of the microdroplets" fluorescence intensity on their volume, as well as characterized the time-dependent enzyme reaction kinetics of beta-galactosidase-mediated cleavage of the substrate fluorescein di-beta-d-galactopyranoside (FDG).	fluorescein-digalactoside	246-285	galactosidase beta 1	Homo sapiens	192-210
31931994-0	2020	Multiwalled carbon nanotubes bound beta-galactosidase: It"s activity, stability and reusability.	Carbon	12-18	galactosidase beta 1	Homo sapiens	35-53
31931994-5	2020	In this chapter, we used polyaniline cobalt multiwalled CNTs to immobilize beta-galactosidase, by adopting both noncovalent and covalent strategies.	polyaniline	25-43	galactosidase beta 1	Homo sapiens	75-93
31563443-8	2019	Using the developed setup, we demonstrated the dependency of the microdroplets" fluorescence intensity on their volume, as well as characterized the time-dependent enzyme reaction kinetics of beta-galactosidase-mediated cleavage of the substrate fluorescein di-beta-d-galactopyranoside (FDG).	fluorescein-digalactoside	287-290	galactosidase beta 1	Homo sapiens	192-210
30942622-0	2019	Safeguarding the catalytic activity and stability of polyaniline chitosan silver nanocomposite bound beta-galactosidase against product inhibitors and structurally related compound.	polyaniline chitosan	53-73	galactosidase beta 1	Homo sapiens	101-119
31777880-1	2019	Reported herein is a novel p-quinone methide-based self-immobilizing fluorogenic probe for the visualization of beta-galactosidase activities in live cells.	quinone methide	29-44	galactosidase beta 1	Homo sapiens	112-130
30942622-1	2019	In this study, an attempt has been made to evaluate the effect of products of beta-galactosidase (betaGS) catalyzed reaction i.e. glucose and galactose and their structurally related compound vitamin C (VC) on the catalytic activity of native and PANI-CS-NC and PANI-CS-Ag-NC adsorbed betaGS.	Glucose	130-137	galactosidase beta 1	Homo sapiens	78-96
30942622-1	2019	In this study, an attempt has been made to evaluate the effect of products of beta-galactosidase (betaGS) catalyzed reaction i.e. glucose and galactose and their structurally related compound vitamin C (VC) on the catalytic activity of native and PANI-CS-NC and PANI-CS-Ag-NC adsorbed betaGS.	Galactose	142-151	galactosidase beta 1	Homo sapiens	78-96
30942622-1	2019	In this study, an attempt has been made to evaluate the effect of products of beta-galactosidase (betaGS) catalyzed reaction i.e. glucose and galactose and their structurally related compound vitamin C (VC) on the catalytic activity of native and PANI-CS-NC and PANI-CS-Ag-NC adsorbed betaGS.	Ascorbic Acid	192-201	galactosidase beta 1	Homo sapiens	78-96
30942622-1	2019	In this study, an attempt has been made to evaluate the effect of products of beta-galactosidase (betaGS) catalyzed reaction i.e. glucose and galactose and their structurally related compound vitamin C (VC) on the catalytic activity of native and PANI-CS-NC and PANI-CS-Ag-NC adsorbed betaGS.	Ascorbic Acid	203-205	galactosidase beta 1	Homo sapiens	78-96
31801274-3	2019	Dry drop blood test (DBS) and colorimetric 2-step enzymatic assay were used to assess the activity of human blood aSMase, beta-galactosidase, and beta-glucosidase, these enzymes are lysosomal hydrolases that catalyze the degradation of related sphingolipids, of sphingolipid signaling molecules.	Sphingolipids	244-257	galactosidase beta 1	Homo sapiens	122-140
31801274-3	2019	Dry drop blood test (DBS) and colorimetric 2-step enzymatic assay were used to assess the activity of human blood aSMase, beta-galactosidase, and beta-glucosidase, these enzymes are lysosomal hydrolases that catalyze the degradation of related sphingolipids, of sphingolipid signaling molecules.	Sphingolipids	244-256	galactosidase beta 1	Homo sapiens	122-140
31124078-10	2019	Prolonged exposure to Palbociclib induced a senescent-like phenotype characterized by flattened morphology, cell cycle arrest, increased beta-galactosidase activity and induction of other senescent-associated markers.	palbociclib	22-33	galactosidase beta 1	Homo sapiens	137-155
31720227-1	2019	Introduction: GM1 gangliosidosis is a rare autosomal recessive genetic disorder caused by the disruption of the GLB1 gene that encodes beta-galactosidase, a lysosomal hydrolase that removes beta-linked galactose from the non-reducing end of glycans.	Galactose	202-211	galactosidase beta 1	Homo sapiens	112-116
31720227-1	2019	Introduction: GM1 gangliosidosis is a rare autosomal recessive genetic disorder caused by the disruption of the GLB1 gene that encodes beta-galactosidase, a lysosomal hydrolase that removes beta-linked galactose from the non-reducing end of glycans.	Galactose	202-211	galactosidase beta 1	Homo sapiens	135-153
31720227-3	2019	In addition to GM1 and GA1, there are other glycoconjugates that contain beta-linked galactose whose metabolites are substrates for beta-galactosidase.	Galactose	85-94	galactosidase beta 1	Homo sapiens	132-150
31720227-11	2019	Conclusions: Our studies illustrate that GLB1 deficiency is not purely a ganglioside accumulation disorder, but instead a broad oligosaccharidosis that include representatives of many beta-linked galactose containing glycans and glycoconjugates including glycolipids, N-linked glycans, and various O-linked glycans.	Galactose	196-205	galactosidase beta 1	Homo sapiens	41-45
31720227-11	2019	Conclusions: Our studies illustrate that GLB1 deficiency is not purely a ganglioside accumulation disorder, but instead a broad oligosaccharidosis that include representatives of many beta-linked galactose containing glycans and glycoconjugates including glycolipids, N-linked glycans, and various O-linked glycans.	Nitrogen	268-269	galactosidase beta 1	Homo sapiens	41-45
31676820-3	2019	A range of enzymes, namely beta-glucosidase, invertase, beta-galactosidase, and catalase, are encapsulated in ZIF-8, UiO-66-NH2, or Zn-MOF-74 via a ball milling process.	T-66	117-127	galactosidase beta 1	Homo sapiens	56-88
31676820-3	2019	A range of enzymes, namely beta-glucosidase, invertase, beta-galactosidase, and catalase, are encapsulated in ZIF-8, UiO-66-NH2, or Zn-MOF-74 via a ball milling process.	Zinc	132-138	galactosidase beta 1	Homo sapiens	56-88
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	47-50	galactosidase beta 1	Homo sapiens	71-75
31395344-1	2019	Galactooligosaccharides (GOS) are currently attracting considerable interest as prebiotic substances and can be prepared by transgalactosylation reactions from lactose using beta-galactosidase.	galactooligosaccharides	0-23	galactosidase beta 1	Homo sapiens	174-192
31395344-1	2019	Galactooligosaccharides (GOS) are currently attracting considerable interest as prebiotic substances and can be prepared by transgalactosylation reactions from lactose using beta-galactosidase.	D-Glucitol-1,6-bisphosphate	25-28	galactosidase beta 1	Homo sapiens	174-192
31395344-1	2019	Galactooligosaccharides (GOS) are currently attracting considerable interest as prebiotic substances and can be prepared by transgalactosylation reactions from lactose using beta-galactosidase.	Lactose	160-167	galactosidase beta 1	Homo sapiens	174-192
31537069-1	2019	There are ongoing interests in improving the galactooligosaccharides (GOS) synthesis efficiency of beta-galactosidase by protein engineering.	galactooligosaccharides	45-68	galactosidase beta 1	Homo sapiens	99-117
31537069-1	2019	There are ongoing interests in improving the galactooligosaccharides (GOS) synthesis efficiency of beta-galactosidase by protein engineering.	D-Glucitol-1,6-bisphosphate	70-73	galactosidase beta 1	Homo sapiens	99-117
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	glbs	38-42	galactosidase beta 1	Homo sapiens	71-75
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	glbs	38-42	galactosidase beta 1	Homo sapiens	174-178
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	47-50	galactosidase beta 1	Homo sapiens	174-178
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	71-75
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	174-178
31453659-5	2019	The most important biological activities of Artemisia"s alkaloids are including hepatoprotective, local anesthetic, beta-galactosidase, and antiparasitic activities; treatment of angina pectoris, opening blocked arteries, as a sleep-inducing agents and inhibition of HIV viral protease, CYP450, melanin biosynthesis, human carbonic anhydrase, [3H]-AEA metabolism, kinases, and DNA polymerase beta1 .	Alkaloids	56-65	galactosidase beta 1	Homo sapiens	116-134
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	71-75
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	174-178
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	71-75
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	174-178
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	71-75
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	174-178
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	71-75
31148289-7	2019	We demonstrate an interaction between Glbs and ABA on several grounds: Glb1 and Glb2 scavenge NO produced in stomatal guard cells following ABA supply; plants overexpressing Glb1 show higher constitutive expression of the ABA responsive genes Responsive to ABA (RAB18), Responsive to Dehydration (RD29A) and Highly ABA-Induced 2 (HAI2), and are more tolerant to dehydration; and ABA strongly upregulates class 1 Glbs.	Abscisic Acid	140-143	galactosidase beta 1	Homo sapiens	174-178
31534909-0	2019	Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis.	G(M1) Ganglioside	112-127	galactosidase beta 1	Homo sapiens	6-10
31260766-0	2019	Oligosaccharides act as the high efficiency stabilizer for beta-galactosidase under heat treatment.	Oligosaccharides	0-16	galactosidase beta 1	Homo sapiens	59-77
31260766-1	2019	beta-Galactosidase (beta-Gal) as dietary supplement has the ability to alleviate symptoms of lactose intolerance.	Lactose	93-100	galactosidase beta 1	Homo sapiens	0-18
31260766-1	2019	beta-Galactosidase (beta-Gal) as dietary supplement has the ability to alleviate symptoms of lactose intolerance.	Lactose	93-100	galactosidase beta 1	Homo sapiens	0-8
31260766-2	2019	This study investigated the ability of oligosaccharides to protect beta-Gal against heat stress.	Oligosaccharides	39-55	galactosidase beta 1	Homo sapiens	67-75
31260766-3	2019	Four kinds of oligosaccharides including Isomalto-oligosaccharides (IMO), Xylo-oligosaccharides (XOS), Konjac-oligosaccharides (KOS), and Mycose significantly increased the activity retention of beta-Gal under heat treatment.	isomalto-oligosaccharides	41-66	galactosidase beta 1	Homo sapiens	195-203
31260766-3	2019	Four kinds of oligosaccharides including Isomalto-oligosaccharides (IMO), Xylo-oligosaccharides (XOS), Konjac-oligosaccharides (KOS), and Mycose significantly increased the activity retention of beta-Gal under heat treatment.	xylooligosaccharide	74-95	galactosidase beta 1	Homo sapiens	195-203
31260766-3	2019	Four kinds of oligosaccharides including Isomalto-oligosaccharides (IMO), Xylo-oligosaccharides (XOS), Konjac-oligosaccharides (KOS), and Mycose significantly increased the activity retention of beta-Gal under heat treatment.	konjac-oligosaccharides	103-126	galactosidase beta 1	Homo sapiens	195-203
31260766-4	2019	The results of three assays including circular dichroism, fluorescence, and Fourier transform infrared spectroscopy (FTIR) illustrated that these oligosaccharides could stabilize the secondary and tertiary structure of beta-Gal under thermal conditions through hydrogen bond interaction.	Oligosaccharides	146-162	galactosidase beta 1	Homo sapiens	219-227
31260766-4	2019	The results of three assays including circular dichroism, fluorescence, and Fourier transform infrared spectroscopy (FTIR) illustrated that these oligosaccharides could stabilize the secondary and tertiary structure of beta-Gal under thermal conditions through hydrogen bond interaction.	Hydrogen	261-269	galactosidase beta 1	Homo sapiens	219-227
31260766-5	2019	Unlike these four oligosaccharides, Chito-oligosaccharides (COS) changed the secondary and tertiary structure of beta-Gal, thus decreasing its activity retention rate.	oligochitosan	36-58	galactosidase beta 1	Homo sapiens	113-121
31260766-5	2019	Unlike these four oligosaccharides, Chito-oligosaccharides (COS) changed the secondary and tertiary structure of beta-Gal, thus decreasing its activity retention rate.	oligochitosan	60-63	galactosidase beta 1	Homo sapiens	113-121
31534909-0	2019	Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis.	G(M1) Ganglioside	112-127	galactosidase beta 1	Homo sapiens	81-85
31534909-7	2019	Analysis of GLB1 knockout organoids in culture revealed progressive accumulation of GM1 ganglioside.	G(M1) Ganglioside	84-99	galactosidase beta 1	Homo sapiens	12-16
31534909-8	2019	GLB1 knockout organoids microinjected with AAV9-GLB1 vector showed a significant increase in beta-gal activity and a significant reduction in GM1 ganglioside content compared with AAV9-GFP-injected organoids, demonstrating the efficacy of an AAV9 gene therapy-based approach in GM1 gangliosidosis.	G(M1) Ganglioside	142-157	galactosidase beta 1	Homo sapiens	0-4
31534909-8	2019	GLB1 knockout organoids microinjected with AAV9-GLB1 vector showed a significant increase in beta-gal activity and a significant reduction in GM1 ganglioside content compared with AAV9-GFP-injected organoids, demonstrating the efficacy of an AAV9 gene therapy-based approach in GM1 gangliosidosis.	G(M1) Ganglioside	142-157	galactosidase beta 1	Homo sapiens	48-52
31480728-5	2019	However, senescence-associated (SA)-beta-galactosidase (beta-gal) was regulated in MCF-7 cells after C2-ceramide treatment.	N-acetylsphingosine	101-112	galactosidase beta 1	Homo sapiens	36-54
31505751-0	2019	Conjugation of Carbon Dots with beta-Galactosidase Enzyme: Surface Chemistry and Use in Biosensing.	Carbon	15-21	galactosidase beta 1	Homo sapiens	32-50
31505751-3	2019	We have developed a sensing platform by the conjugation of beta-galactosidase, a crucial enzyme, with lab-synthesized gel-like carbon dots (CDs) which have high luminescence, photostability, and easy surface functionalization.	Methane	127-138	galactosidase beta 1	Homo sapiens	59-77
31505751-3	2019	We have developed a sensing platform by the conjugation of beta-galactosidase, a crucial enzyme, with lab-synthesized gel-like carbon dots (CDs) which have high luminescence, photostability, and easy surface functionalization.	cds	140-143	galactosidase beta 1	Homo sapiens	59-77
31523478-5	2019	73.33% of the beta-galactosidase missense mutants could be rescued by salt, while only 33.33% of the catechol 2,3 dioxygenase missense mutants could be rescued by salt.	Salts	70-74	galactosidase beta 1	Homo sapiens	14-32
31269795-1	2019	beta-Galactosidase (beta-Gal), as a lysosomal hydrolytic enzyme, plays an important physiological role in catalyzing the hydrolysis of glycosidic bonds which convert lactose into galactose.	Lactose	166-173	galactosidase beta 1	Homo sapiens	0-18
31269795-1	2019	beta-Galactosidase (beta-Gal), as a lysosomal hydrolytic enzyme, plays an important physiological role in catalyzing the hydrolysis of glycosidic bonds which convert lactose into galactose.	Lactose	166-173	galactosidase beta 1	Homo sapiens	0-8
31269795-1	2019	beta-Galactosidase (beta-Gal), as a lysosomal hydrolytic enzyme, plays an important physiological role in catalyzing the hydrolysis of glycosidic bonds which convert lactose into galactose.	Galactose	179-188	galactosidase beta 1	Homo sapiens	0-18
31269795-1	2019	beta-Galactosidase (beta-Gal), as a lysosomal hydrolytic enzyme, plays an important physiological role in catalyzing the hydrolysis of glycosidic bonds which convert lactose into galactose.	Galactose	179-188	galactosidase beta 1	Homo sapiens	0-8
31523478-7	2019	Catechol 2,3 dioxygenase is almost twice as dense or compact as beta-galactosidase and thus it is far easier for salts to penetrate and rescue inactive beta-galactosidase proteins.	catechol	0-8	galactosidase beta 1	Homo sapiens	152-170
31700699-3	2019	Furthermore, the G1 phase of cell cycle with high activity of senescence-associated beta-galactosidase was also significantly (P &lt; .05) increased in the 250 muM NVP-treated DSCs, compared with untreated DSCs.	Nevirapine	164-167	galactosidase beta 1	Homo sapiens	84-102
30959081-3	2019	In the current study, inhibitory effects on AGEs formation were investigated using bio-enzymatically synthesized nanoformulations of gold (AuNPs) and silver (AgNPs) by physiologically important enzyme, beta galactosidase.	Silver	150-156	galactosidase beta 1	Homo sapiens	202-220
30902269-0	2019	Design of combined crosslinked enzyme aggregates (combi-CLEAs) of beta-galactosidase and glucose isomerase for the one-pot production of fructose syrup from lactose.	combi-cleas	50-61	galactosidase beta 1	Homo sapiens	66-84
30902269-0	2019	Design of combined crosslinked enzyme aggregates (combi-CLEAs) of beta-galactosidase and glucose isomerase for the one-pot production of fructose syrup from lactose.	Fructose	137-145	galactosidase beta 1	Homo sapiens	66-84
30902269-0	2019	Design of combined crosslinked enzyme aggregates (combi-CLEAs) of beta-galactosidase and glucose isomerase for the one-pot production of fructose syrup from lactose.	Lactose	157-164	galactosidase beta 1	Homo sapiens	66-84
30902269-1	2019	A new bi-enzymatic catalyst has been produced by precipitation and crosslinking (combi-CLEAs) of beta-galactosidase and glucose isomerase for catalyzing the cascade reactions of lactose conversion into fructose, producing a lactose-fructose syrup (LFS).	Lactose	178-185	galactosidase beta 1	Homo sapiens	97-115
30902269-1	2019	A new bi-enzymatic catalyst has been produced by precipitation and crosslinking (combi-CLEAs) of beta-galactosidase and glucose isomerase for catalyzing the cascade reactions of lactose conversion into fructose, producing a lactose-fructose syrup (LFS).	Fructose	202-210	galactosidase beta 1	Homo sapiens	97-115
30508396-5	2019	Fetal ASM exposed to 40% O2 for 7 days exhibited elevated concentrations of senescence-associated markers, including beta-galactosidase; cell cycle checkpoint proteins p16, p21, and p-p53; and the DNA damage marker p-gammaH2A.X (phosphorylated gamma-histone family member X).	Oxygen	25-27	galactosidase beta 1	Homo sapiens	117-135
30508396-6	2019	The combination of dasatinib and quercetin, compounds known to eliminate senescent cells (senolytics), reduced the number of hyperoxia-exposed beta-galactosidase-, p21-, p16-, and p-gammaH2A.X-positive ASM cells.	Dasatinib	19-28	galactosidase beta 1	Homo sapiens	143-161
30508396-6	2019	The combination of dasatinib and quercetin, compounds known to eliminate senescent cells (senolytics), reduced the number of hyperoxia-exposed beta-galactosidase-, p21-, p16-, and p-gammaH2A.X-positive ASM cells.	Quercetin	33-42	galactosidase beta 1	Homo sapiens	143-161
30608861-6	2019	Exposing human lung fibroblasts to 150 muM hydrogen peroxide (H2O2) resulted in increased senescence-associated beta-galactosidase content and expression of p21 and IL-6, all of which are features of senescence.	Hydrogen Peroxide	43-60	galactosidase beta 1	Homo sapiens	112-130
30608861-6	2019	Exposing human lung fibroblasts to 150 muM hydrogen peroxide (H2O2) resulted in increased senescence-associated beta-galactosidase content and expression of p21 and IL-6, all of which are features of senescence.	Hydrogen Peroxide	62-66	galactosidase beta 1	Homo sapiens	112-130
30608861-9	2019	Targeting STAT3 activity using the small-molecule inhibitor STA-21 attenuated IL-6 production, reduced p21 levels, decreased senescence-associated beta-galactosidase accumulation, and restored normal mitochondrial function.	STA-21	60-66	galactosidase beta 1	Homo sapiens	147-165
30959081-3	2019	In the current study, inhibitory effects on AGEs formation were investigated using bio-enzymatically synthesized nanoformulations of gold (AuNPs) and silver (AgNPs) by physiologically important enzyme, beta galactosidase.	aunps	139-144	galactosidase beta 1	Homo sapiens	202-220
31081634-3	2019	In this paper, we immobilized a beta-galactosidase enzyme in the LB films of stearic acid and the conjugated polymer poly[(9,9-dioctylfluorene)- co-thiophene].	stearic acid	77-89	galactosidase beta 1	Homo sapiens	32-50
31038250-0	2019	Calmodulin-like skin protein suppresses the increase in senescence-associated beta-galactosidase induced by hydrogen peroxide or ultraviolet irradiation in keratinocytes.	Hydrogen Peroxide	108-125	galactosidase beta 1	Homo sapiens	78-96
31038250-6	2019	Furthermore, co-incubation with recombinant CLSP reduced the increase in senescence-associated beta-galactosidase-positivity in keratinocytes that were induced by H2 O2 or UV.	Hydrogen Peroxide	163-168	galactosidase beta 1	Homo sapiens	95-113
31361226-9	2019	The activity of beta-galactosidase was colorimetrically estimated in the cell lysate using orthonitro phenyl beta-D-galactopyanoside (ONPG) as a substrate.	orthonitro phenyl beta-d-galactopyanoside	91-132	galactosidase beta 1	Homo sapiens	16-34
31361226-9	2019	The activity of beta-galactosidase was colorimetrically estimated in the cell lysate using orthonitro phenyl beta-D-galactopyanoside (ONPG) as a substrate.	2-Nitrophenyl-beta-D-galactopyranoside	134-138	galactosidase beta 1	Homo sapiens	16-34
31305507-5	2019	Live cell measurements of senescence-associated beta-galactosidase (SA-beta-Gal) activity using the fluorescent substrate C12FDG in combination with the determination of the total cell number using a DNA intercalating Hoechst dye opens the possibility to screen for senotherapeutic drugs that either reduce overall SA-beta-Gal activity by killing of senescent cells (senolytics) or by suppressing SA-beta-Gal and other phenotypes of senescent cells (senomorphics).	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	68-79	galactosidase beta 1	Homo sapiens	48-66
31305507-5	2019	Live cell measurements of senescence-associated beta-galactosidase (SA-beta-Gal) activity using the fluorescent substrate C12FDG in combination with the determination of the total cell number using a DNA intercalating Hoechst dye opens the possibility to screen for senotherapeutic drugs that either reduce overall SA-beta-Gal activity by killing of senescent cells (senolytics) or by suppressing SA-beta-Gal and other phenotypes of senescent cells (senomorphics).	5-octanoylaminofluorescein digalactopyranoside	122-128	galactosidase beta 1	Homo sapiens	48-66
31115488-5	2019	GDP-Man (30 microg/ml GDP-Man PLGA NPs) was incubated for 48 h with the cells and the specific activities of alpha-mannosidase and beta-galactosidase were estimated at 69 and 92% compared with healthy controls.	GDP-D-mannose disodium salt	0-7	galactosidase beta 1	Homo sapiens	131-149
31115488-5	2019	GDP-Man (30 microg/ml GDP-Man PLGA NPs) was incubated for 48 h with the cells and the specific activities of alpha-mannosidase and beta-galactosidase were estimated at 69 and 92% compared with healthy controls.	GDP-D-mannose disodium salt	22-29	galactosidase beta 1	Homo sapiens	131-149
31081634-3	2019	In this paper, we immobilized a beta-galactosidase enzyme in the LB films of stearic acid and the conjugated polymer poly[(9,9-dioctylfluorene)- co-thiophene].	(9,9-dioctylfluorene)- co-thiophene	122-157	galactosidase beta 1	Homo sapiens	32-50
30836860-4	2019	Here we show that PFG can induce cellular senescence, evidenced by the expression of senescence-associated beta-galactosidase, G0/G1 cell cycle arrest and permanent loss of proliferative ability, in normal TIG-1 diploid fibroblast but not cancerous HeLa cells.	pfg	18-21	galactosidase beta 1	Homo sapiens	107-125
30805890-2	2019	The staining of SA-beta-galactosidase, an aging marker, was remarkably increased in the cells aged with H2O2 at 62.5 microM or more compared with young cells.	Hydrogen Peroxide	104-108	galactosidase beta 1	Homo sapiens	19-37
31205361-2	2019	Lactose intolerance affects more than 70% of the world population, being apparent by the absence of beta-galactosidase enzyme, thus leading to the inability to consume dairy products.	Lactose	0-7	galactosidase beta 1	Homo sapiens	100-118
30852321-7	2019	Enzymatic removal of sialic acids results in the removal of galactose residues from the EPS upon subsequent treatment with beta-galactosidase, indicating a linkage between galactose and sialic acid at the terminus of glycan chains.	Sialic Acids	21-33	galactosidase beta 1	Homo sapiens	123-141
30852321-7	2019	Enzymatic removal of sialic acids results in the removal of galactose residues from the EPS upon subsequent treatment with beta-galactosidase, indicating a linkage between galactose and sialic acid at the terminus of glycan chains.	Galactose	60-69	galactosidase beta 1	Homo sapiens	123-141
30852321-7	2019	Enzymatic removal of sialic acids results in the removal of galactose residues from the EPS upon subsequent treatment with beta-galactosidase, indicating a linkage between galactose and sialic acid at the terminus of glycan chains.	Galactose	172-181	galactosidase beta 1	Homo sapiens	123-141
30852321-7	2019	Enzymatic removal of sialic acids results in the removal of galactose residues from the EPS upon subsequent treatment with beta-galactosidase, indicating a linkage between galactose and sialic acid at the terminus of glycan chains.	N-Acetylneuraminic Acid	21-32	galactosidase beta 1	Homo sapiens	123-141
30852321-7	2019	Enzymatic removal of sialic acids results in the removal of galactose residues from the EPS upon subsequent treatment with beta-galactosidase, indicating a linkage between galactose and sialic acid at the terminus of glycan chains.	Polysaccharides	217-223	galactosidase beta 1	Homo sapiens	123-141
31030313-0	2019	Enzymatic synthesis of beta-galactosyl fucose using recombinant bifidobacterial beta-galactosidase and its prebiotic effect.	beta-galactosyl fucose	23-45	galactosidase beta 1	Homo sapiens	80-98
31139612-3	2019	In this work, we developed an elaborated near-infrared (NIR) aggregation-induced emission (AIE)-active fluorescent probe, which is composed of a hydrophobic 2-(2-hydroxyphenyl) benzothiazole (HBT) moiety for extending into the NIR wavelength, and a hydrophilic beta-galactosidase (beta-gal) triggered unit for improving miscibility and guaranteeing its non-emission in aqueous media.	hbt	192-195	galactosidase beta 1	Homo sapiens	261-279
31139612-3	2019	In this work, we developed an elaborated near-infrared (NIR) aggregation-induced emission (AIE)-active fluorescent probe, which is composed of a hydrophobic 2-(2-hydroxyphenyl) benzothiazole (HBT) moiety for extending into the NIR wavelength, and a hydrophilic beta-galactosidase (beta-gal) triggered unit for improving miscibility and guaranteeing its non-emission in aqueous media.	hbt	192-195	galactosidase beta 1	Homo sapiens	261-269
31139612-4	2019	This probe is virtually activated by beta-gal, and then specific enzymatic turnover would liberate hydrophobic AIE luminogen (AIEgen) QM-HBT-OH.	aie luminogen	111-124	galactosidase beta 1	Homo sapiens	37-45
31139612-4	2019	This probe is virtually activated by beta-gal, and then specific enzymatic turnover would liberate hydrophobic AIE luminogen (AIEgen) QM-HBT-OH.	aiegen	126-132	galactosidase beta 1	Homo sapiens	37-45
31139612-4	2019	This probe is virtually activated by beta-gal, and then specific enzymatic turnover would liberate hydrophobic AIE luminogen (AIEgen) QM-HBT-OH.	qm-hbt-oh	134-143	galactosidase beta 1	Homo sapiens	37-45
31139612-6	2019	By virtue of the NIR AIE-active performance of enzyme-catalyzed nanoaggregates, QM-HBT-betagal is capable of affording a localizable fluorescence signal and long-term tracking of endogenous beta-gal activity.	qm-hbt-betagal	80-94	galactosidase beta 1	Homo sapiens	190-198
30611496-0	2019	Effect of metal ions present in milk on the structure and functional integrity of native and polyaniline chitosan nanocomposites bound beta-galactosidase: A multi-spectroscopic approach.	Metals	10-15	galactosidase beta 1	Homo sapiens	135-153
30611496-0	2019	Effect of metal ions present in milk on the structure and functional integrity of native and polyaniline chitosan nanocomposites bound beta-galactosidase: A multi-spectroscopic approach.	polyaniline	93-104	galactosidase beta 1	Homo sapiens	135-153
30611496-1	2019	beta-Galactosidase is vital to dairy industries because it catalyzes the hydrolysis of lactose into glucose and galactose making it useful for lactose intolerant patients to consume milk and its products.	Lactose	87-94	galactosidase beta 1	Homo sapiens	0-18
30611496-1	2019	beta-Galactosidase is vital to dairy industries because it catalyzes the hydrolysis of lactose into glucose and galactose making it useful for lactose intolerant patients to consume milk and its products.	Glucose	100-107	galactosidase beta 1	Homo sapiens	0-18
30611496-1	2019	beta-Galactosidase is vital to dairy industries because it catalyzes the hydrolysis of lactose into glucose and galactose making it useful for lactose intolerant patients to consume milk and its products.	Galactose	112-121	galactosidase beta 1	Homo sapiens	0-18
30611496-2	2019	The present study demonstrates the effect of metal ions commonly found in milk, namely Zn2+, K+, Ca2+ and Mn2+ on the activity of native and polyaniline chitosan nanocomposites bound Aspergillus oryzae beta-galactosidase.	Metals	45-50	galactosidase beta 1	Homo sapiens	202-220
30611496-2	2019	The present study demonstrates the effect of metal ions commonly found in milk, namely Zn2+, K+, Ca2+ and Mn2+ on the activity of native and polyaniline chitosan nanocomposites bound Aspergillus oryzae beta-galactosidase.	Manganese(2+)	106-110	galactosidase beta 1	Homo sapiens	202-220
30611496-2	2019	The present study demonstrates the effect of metal ions commonly found in milk, namely Zn2+, K+, Ca2+ and Mn2+ on the activity of native and polyaniline chitosan nanocomposites bound Aspergillus oryzae beta-galactosidase.	polyaniline	141-152	galactosidase beta 1	Homo sapiens	202-220
30611496-3	2019	In polyaniline chitosan silver nanocomposite adsorbed beta-galactosidase, a multi-fold enhancement in catalytic activity was observed in the presence of cocktail of Zn2+, K+, Ca2+ and Mn2+ ions.	polyaniline chitosan	3-23	galactosidase beta 1	Homo sapiens	54-72
30611496-3	2019	In polyaniline chitosan silver nanocomposite adsorbed beta-galactosidase, a multi-fold enhancement in catalytic activity was observed in the presence of cocktail of Zn2+, K+, Ca2+ and Mn2+ ions.	Zinc	165-169	galactosidase beta 1	Homo sapiens	54-72
30611496-3	2019	In polyaniline chitosan silver nanocomposite adsorbed beta-galactosidase, a multi-fold enhancement in catalytic activity was observed in the presence of cocktail of Zn2+, K+, Ca2+ and Mn2+ ions.	Manganese(2+)	184-188	galactosidase beta 1	Homo sapiens	54-72
30611496-4	2019	3D fluorescence, CD and FTIR studies established significant conformational changes in the secondary structure of polyaniline chitosan silver nanocomposite bound beta-galactosidase on addition of metal ions as compared to the native and other bound enzyme.	polyaniline chitosan	114-134	galactosidase beta 1	Homo sapiens	162-180
30611496-4	2019	3D fluorescence, CD and FTIR studies established significant conformational changes in the secondary structure of polyaniline chitosan silver nanocomposite bound beta-galactosidase on addition of metal ions as compared to the native and other bound enzyme.	Silver	135-141	galactosidase beta 1	Homo sapiens	162-180
30611496-4	2019	3D fluorescence, CD and FTIR studies established significant conformational changes in the secondary structure of polyaniline chitosan silver nanocomposite bound beta-galactosidase on addition of metal ions as compared to the native and other bound enzyme.	Metals	196-201	galactosidase beta 1	Homo sapiens	162-180
30708952-0	2019	Degradation of Proteins and Starch by Combined Immobilization of Protease, alpha-Amylase and beta-Galactosidase on a Single Electrospun Nanofibrous Membrane.	Starch	28-34	galactosidase beta 1	Homo sapiens	93-111
30740957-4	2019	METHODS: The effects of olaparib on the senescence of ovarian cancer cells were detected by using the senescence-associated beta-galactosidase (SA-beta-Gal) and senescence-associated heterochromatin aggregation (SAHF).	olaparib	24-32	galactosidase beta 1	Homo sapiens	124-142
30863014-10	2019	The remarkably higher positive rate of senescence-associated beta-galactosidase and increased intracellular ROS levels in the H2O2 treatment group were reversed by treatment with 10 microM RESV.	Hydrogen Peroxide	126-130	galactosidase beta 1	Homo sapiens	61-79
30703229-9	2019	CONCLUSION: The c.2006-2007insT and c.475-476 insGGTCC mutations of the GLB1 gene probably underlie the GM1 gangliosidosis resulting in the growth retardation in the child.	G(M1) Ganglioside	104-107	galactosidase beta 1	Homo sapiens	72-76
30609517-0	2019	New optical method for the determination of beta-galactosidase and alpha-fetoprotein based on oxidase-like activity of fluorescein.	Fluorescein	119-130	galactosidase beta 1	Homo sapiens	44-62
30609517-2	2019	Herein, a facile colorimetric strategy for beta-galactosidase (beta-gal) was developed using fluorescein di beta-D-galactopyranoside (FDG) as a probe based on the analyte induced change in oxidase mimicking activity of fluorescein derivatives.	fluorescein-digalactoside	93-132	galactosidase beta 1	Homo sapiens	43-61
30609517-2	2019	Herein, a facile colorimetric strategy for beta-galactosidase (beta-gal) was developed using fluorescein di beta-D-galactopyranoside (FDG) as a probe based on the analyte induced change in oxidase mimicking activity of fluorescein derivatives.	fluorescein-digalactoside	93-132	galactosidase beta 1	Homo sapiens	43-51
30609517-2	2019	Herein, a facile colorimetric strategy for beta-galactosidase (beta-gal) was developed using fluorescein di beta-D-galactopyranoside (FDG) as a probe based on the analyte induced change in oxidase mimicking activity of fluorescein derivatives.	Fluorescein	93-104	galactosidase beta 1	Homo sapiens	43-61
30609517-2	2019	Herein, a facile colorimetric strategy for beta-galactosidase (beta-gal) was developed using fluorescein di beta-D-galactopyranoside (FDG) as a probe based on the analyte induced change in oxidase mimicking activity of fluorescein derivatives.	Fluorescein	93-104	galactosidase beta 1	Homo sapiens	43-51
30609517-3	2019	FDG doesn"t possess any visible-light-induced oxidase activity and can generate fluorescein and fluorescein mono beta-D-galactopyranoside (FMG) in the presence of beta-gal.	fmg	139-142	galactosidase beta 1	Homo sapiens	163-171
30723285-5	2019	We synthesized NO-Rosa-Gal bearing D-galactose (Gal) at this location, and showed that hydrolysis by beta-galactosidase restored the photoresponse.	Galactose	35-46	galactosidase beta 1	Homo sapiens	101-119
30723285-5	2019	We synthesized NO-Rosa-Gal bearing D-galactose (Gal) at this location, and showed that hydrolysis by beta-galactosidase restored the photoresponse.	Galactose	23-26	galactosidase beta 1	Homo sapiens	101-119
30404027-1	2019	In the present work, we aimed to explore the molecular binding between alginate and beta-galactosidase, as well as the effect of this interaction on the activity retention, thermal stability, and kinetic properties of the enzyme.	Alginates	71-79	galactosidase beta 1	Homo sapiens	84-102
30404027-4	2019	The binding between beta-galactosidase and alginate was an equilibrium between enthalpic and entropic contributions, which promoted changes in the structure of the enzyme.	Alginates	43-51	galactosidase beta 1	Homo sapiens	20-38
30097403-1	2019	In this study, an amino-functionalized silica matrix encapsulating beta-galactosidase was first synthesized in situ, with subsequent covalent anchoring of lysozyme to the outer part of the amino-grafted matrix.	Silicon Dioxide	39-45	galactosidase beta 1	Homo sapiens	67-85
30348394-2	2019	A novel, ratiometric water-soluble fluorescent probe (FLM) for beta-gal was developed.	Water	21-26	galactosidase beta 1	Homo sapiens	63-71
30497782-0	2019	beta-sheet to alpha-helix conversion and thermal stability of beta-Galactosidase encapsulated in a nanoporous silica gel.	Silica Gel	110-120	galactosidase beta 1	Homo sapiens	62-80
30555092-0	2018	Identification of a novel GLB1 mutation in a consanguineous Pakistani family affected by rare infantile GM1 gangliosidosis.	G(M1) Ganglioside	104-107	galactosidase beta 1	Homo sapiens	26-30
30230030-8	2019	Moreover, magnolin increased SA-beta-galactosidase-positive cells in a dose-dependent manner in TOV-112D cells, but not in SKOV3 cells.	magnolin	10-18	galactosidase beta 1	Homo sapiens	32-50
30675867-1	2019	GM1 gangliosidosis is an autosomal recessive disorder caused by galactosidase beta1 (GLB1) gene variants which affect the activity of beta-galactosidase (GLB).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	64-83
30675867-1	2019	GM1 gangliosidosis is an autosomal recessive disorder caused by galactosidase beta1 (GLB1) gene variants which affect the activity of beta-galactosidase (GLB).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	85-89
30675867-1	2019	GM1 gangliosidosis is an autosomal recessive disorder caused by galactosidase beta1 (GLB1) gene variants which affect the activity of beta-galactosidase (GLB).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	134-152
30411897-4	2018	Anthocyanin- and flavonoid-rich fractions shared similar advantages in preventing the expression of senescence-associated beta-galactosidase (34.8% +- 11.1% and 32.2% +- 9.7% of aged cells, respectively) and overexpression of vascular endothelial growth factor (51.8 +- 3.5 and 54.1 +- 6.5 pg/mL, respectively).	Anthocyanins	0-11	galactosidase beta 1	Homo sapiens	122-140
30411897-4	2018	Anthocyanin- and flavonoid-rich fractions shared similar advantages in preventing the expression of senescence-associated beta-galactosidase (34.8% +- 11.1% and 32.2% +- 9.7% of aged cells, respectively) and overexpression of vascular endothelial growth factor (51.8 +- 3.5 and 54.1 +- 6.5 pg/mL, respectively).	Flavonoids	17-26	galactosidase beta 1	Homo sapiens	122-140
30411897-7	2018	Improved inhibitory effects of polyphenol mixture on cell death and senescence-associated beta-galactosidase expression were also observed.	Polyphenols	31-41	galactosidase beta 1	Homo sapiens	90-108
29991711-7	2018	Knockdown of Rictor or treatment with the Akt inhibitor MK-2206 attenuated senescence-associated beta-galactosidase (beta-gal) staining and expression of p53 and p21 proteins in the senescent endothelial cells, suggesting that mTORC2/Akt facilitates endothelial senescence.	MK 2206	56-63	galactosidase beta 1	Homo sapiens	97-115
29991711-7	2018	Knockdown of Rictor or treatment with the Akt inhibitor MK-2206 attenuated senescence-associated beta-galactosidase (beta-gal) staining and expression of p53 and p21 proteins in the senescent endothelial cells, suggesting that mTORC2/Akt facilitates endothelial senescence.	MK 2206	56-63	galactosidase beta 1	Homo sapiens	97-105
30273665-10	2018	The trehalose/pullulan ratio had no impact on the stability of lysozyme, while the stability of beta-galactosidase increased with increasing trehalose/pullulan ratios.	Trehalose	141-150	galactosidase beta 1	Homo sapiens	96-114
30273665-10	2018	The trehalose/pullulan ratio had no impact on the stability of lysozyme, while the stability of beta-galactosidase increased with increasing trehalose/pullulan ratios.	pullulan	151-159	galactosidase beta 1	Homo sapiens	96-114
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	0-32	galactosidase beta 1	Homo sapiens	145-161
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	0-32	galactosidase beta 1	Homo sapiens	163-167
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	34-37	galactosidase beta 1	Homo sapiens	124-132
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	34-37	galactosidase beta 1	Homo sapiens	145-161
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	0-32	galactosidase beta 1	Homo sapiens	124-132
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	34-37	galactosidase beta 1	Homo sapiens	163-167
29746796-0	2018	Detection of Bacteria in Water with beta-Galactosidase-Coated Magnetic Nanoparticles.	Water	25-30	galactosidase beta 1	Homo sapiens	36-54
30267299-1	2018	GM1 gangliosidosis is an autosomal recessive lysosomal storage disease caused by the deficiency of beta-galactosidase activity, precisely due to mutations in the GLB1 gene.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	162-166
30267299-2	2018	To explore the clinical and molecular characteristics of GM1 gangliosidosis patients from China, GLB1 gene were analyzed in 11 probands with GM1 gangliosidosis by exploiting direct Sanger-sequencing.	G(M1) Ganglioside	57-60	galactosidase beta 1	Homo sapiens	97-101
30267299-2	2018	To explore the clinical and molecular characteristics of GM1 gangliosidosis patients from China, GLB1 gene were analyzed in 11 probands with GM1 gangliosidosis by exploiting direct Sanger-sequencing.	G(M1) Ganglioside	141-144	galactosidase beta 1	Homo sapiens	97-101
30542517-7	2018	In this study two enzyme activatable probes, gamma-glutamylhydroxymethyl rhodamine green (gGlu-HMRG) that reacted with gamma-glutamyltransferase and SPiDER-betaGal that reacted with beta-galactosidase, were employed to determine the effects of temperature on fluorescence signal kinetics in both fresh and frozen and then thawed ex vivo experimental ovarian cancer tissue samples.	rhodamine green	73-88	galactosidase beta 1	Homo sapiens	182-200
30581635-1	2018	GM1 gangliosidosis is an autosomal recessive lysosomal storage disorder due to mutations in the lysosomal acid 3-galactosidase gene, GLB1.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	133-137
30172326-2	2018	They function by beta-gal-cleaving the beta-galactoside bond of fluorescent substrates, followed by self-immolation to liberate the amino group of fluorophore.	beta-galactoside	39-55	galactosidase beta 1	Homo sapiens	17-25
30177150-1	2018	beta-galactosidase was successfully immobilized onto chitosan (CS)/polyvinyl alcohol (PVA) blend nanofibers through electrospinning.	Chitosan	63-65	galactosidase beta 1	Homo sapiens	0-18
30177150-1	2018	beta-galactosidase was successfully immobilized onto chitosan (CS)/polyvinyl alcohol (PVA) blend nanofibers through electrospinning.	Polyvinyl Alcohol	67-84	galactosidase beta 1	Homo sapiens	0-18
30177150-1	2018	beta-galactosidase was successfully immobilized onto chitosan (CS)/polyvinyl alcohol (PVA) blend nanofibers through electrospinning.	Polyvinyl Alcohol	86-89	galactosidase beta 1	Homo sapiens	0-18
30194939-5	2018	Increased levels of ATM, HMGA2, phosphorylated ATM, and SA-beta-galactosidase staining indicated that EGCG caused cellular senescence, whereas BIX-01294 did not.	epigallocatechin gallate	102-106	galactosidase beta 1	Homo sapiens	59-77
30350619-2	2018	Lactose was equipped with an azide-functionalized linker and was supplemented to bacterial cultures as an artificial substrate for bacterial beta-galactosidase enzyme.	Lactose	0-7	galactosidase beta 1	Homo sapiens	141-159
30350619-2	2018	Lactose was equipped with an azide-functionalized linker and was supplemented to bacterial cultures as an artificial substrate for bacterial beta-galactosidase enzyme.	Azides	29-34	galactosidase beta 1	Homo sapiens	141-159
30270003-1	2018	(5aR)-5a-C-pentyl-4-epi-isofagomine 1 is a powerful inhibitor of lysosomal beta-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.	(5aR)-5a-C-pentyl-4-epi-isofagomine	0-35	galactosidase beta 1	Homo sapiens	75-93
30270410-3	2018	The self-assembled protein-enzyme conjugates streptavidin (SA) -beta-galactosidase (beta-Gal)-CaHPO4 nanoflowers load sufficient enzymes without damaging their activity, which meets the requirements of signal tags for biosensing.	calcium phosphate, dibasic, anhydrous	94-100	galactosidase beta 1	Homo sapiens	64-82
30270003-4	2018	Based on these results and on docking studies, the 5-C-pentyl derivative 1 was selected as the optimal structure for further investigations: this compound induces the maturation of mutated beta-galactosidase in fibroblasts of a GM1-gangliosidosis patient and promote the decrease of keratan sulfate and oligosaccharide load in patient cells.	Keratan Sulfate	283-298	galactosidase beta 1	Homo sapiens	189-207
30270003-4	2018	Based on these results and on docking studies, the 5-C-pentyl derivative 1 was selected as the optimal structure for further investigations: this compound induces the maturation of mutated beta-galactosidase in fibroblasts of a GM1-gangliosidosis patient and promote the decrease of keratan sulfate and oligosaccharide load in patient cells.	Oligosaccharides	303-318	galactosidase beta 1	Homo sapiens	189-207
30375484-3	2018	In cells with glucocorticoid receptor-alpha (GR) expression corresponding to higher clinical tumor levels, Dex-induced growth arrest was followed by marked cell expansion, beta-galactosidase expression and Ki67 negativity, despite variable p53 and K-RAS status.	Dexamethasone	107-110	galactosidase beta 1	Homo sapiens	172-190
30176285-2	2018	In the present study, spray congealing was used to prepare solid lipid microparticles (SLMs) loaded with beta-galactosidase (lactase), an enzyme used for the treatment of lactose intolerance, to achieve a local drug delivery to the small intestine.	Lactose	171-178	galactosidase beta 1	Homo sapiens	105-123
30187681-1	2018	BACKGROUND: Beta-galactosidase-1 (GLB1) is a lysosomal hydrolase that is responsible for breaking down specific glycoconjugates, particularly GM1 (monosialotetrahexosylganglioside).	G(M1) Ganglioside	142-145	galactosidase beta 1	Homo sapiens	34-38
30187681-1	2018	BACKGROUND: Beta-galactosidase-1 (GLB1) is a lysosomal hydrolase that is responsible for breaking down specific glycoconjugates, particularly GM1 (monosialotetrahexosylganglioside).	G(M1) Ganglioside	147-179	galactosidase beta 1	Homo sapiens	34-38
30187681-4	2018	We present a 22-month-old proband with GM1 gangliosidosis type II (late-infantile form) in whom a novel homozygous in-frame deletion (c.1468_1470delAAC, p.Asn490del) in GLB1 was detected.	G(M1) Ganglioside	39-42	galactosidase beta 1	Homo sapiens	169-173
32254972-0	2018	Lipid-coated mesoporous silica microparticles for the controlled delivery of beta-galactosidase into intestines.	mesoporous silica	13-30	galactosidase beta 1	Homo sapiens	77-95
30276401-2	2018	Here, we report a beta-galactosidase (beta-gal)-responsive acetaminophen (beta-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection.	Acetaminophen	59-72	galactosidase beta 1	Homo sapiens	18-36
30276401-2	2018	Here, we report a beta-galactosidase (beta-gal)-responsive acetaminophen (beta-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection.	Acetaminophen	59-72	galactosidase beta 1	Homo sapiens	18-26
30276401-2	2018	Here, we report a beta-galactosidase (beta-gal)-responsive acetaminophen (beta-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection.	beta-gr-apap	74-86	galactosidase beta 1	Homo sapiens	18-36
30276401-2	2018	Here, we report a beta-galactosidase (beta-gal)-responsive acetaminophen (beta-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection.	beta-gr-apap	74-86	galactosidase beta 1	Homo sapiens	18-26
30746088-3	2019	Here we report an enzyme-activatable aggregation-induced emission (AIE) probe QM-betagal, which is composed of a hydrophilic beta-galactosidase (beta-gal)-triggered galactose moiety and a hydrophobic AIE-active fluorophore QM-OH.	Galactose	165-174	galactosidase beta 1	Homo sapiens	125-143
30746088-3	2019	Here we report an enzyme-activatable aggregation-induced emission (AIE) probe QM-betagal, which is composed of a hydrophilic beta-galactosidase (beta-gal)-triggered galactose moiety and a hydrophobic AIE-active fluorophore QM-OH.	Galactose	165-174	galactosidase beta 1	Homo sapiens	125-133
30746088-5	2019	Notably, taking advantage of the improved intracellular retention of nanoaggregates, we further exemplify QM-betagal for long-term (~12 h) visualization of beta-gal-overexpressing ovarian cancer cells with high fidelity, which is essential for biomedicine and diagnostics.	biomedicine	244-255	galactosidase beta 1	Homo sapiens	156-164
30886651-8	2018	Finally, integrated devices were used to perform a proof-of-concept in-droplet beta-galactosidase enzymatic assay combining enzyme-magnetic bead containing droplet generation, resorufin-beta-D-galactopyranoside substrate injection, enzyme-substrate reaction, and enzyme-magnetic bead washing.	resorufin galactopyranoside	176-210	galactosidase beta 1	Homo sapiens	79-97
29784319-3	2018	The extract was then treated with beta-galactosidase to hydrolyze GOS and lactose.	D-Glucitol-1,6-bisphosphate	66-69	galactosidase beta 1	Homo sapiens	34-52
29784319-3	2018	The extract was then treated with beta-galactosidase to hydrolyze GOS and lactose.	Lactose	74-81	galactosidase beta 1	Homo sapiens	34-52
29784319-6	2018	The glucose in a beta-galactosidase solution was also determined.	Glucose	4-11	galactosidase beta 1	Homo sapiens	17-35
29922971-1	2018	beta-Galactosidase is an essential enzyme for the metabolism of lactose in human beings and has an important role in the treatment of lactose intolerance (LI).	Lactose	64-71	galactosidase beta 1	Homo sapiens	0-18
29922971-1	2018	beta-Galactosidase is an essential enzyme for the metabolism of lactose in human beings and has an important role in the treatment of lactose intolerance (LI).	Lactose	134-141	galactosidase beta 1	Homo sapiens	0-18
29922971-2	2018	beta-Galactosidase expressed by intestinal microflora, such as lactic acid bacteria (LAB), also alleviates LI.	Lactic Acid	63-74	galactosidase beta 1	Homo sapiens	0-18
29922971-5	2018	Western blot and immunofluorescence analyses confirmed that beta-galactosidase was expressed on the cell surface of recombinant L. lactis stain NZ-SDL.	nz-sdl	144-150	galactosidase beta 1	Homo sapiens	60-78
32254972-1	2018	beta-Galactosidase has been drawing increasing attention for the treatment of lactose intolerance, but its delivery has been impeded by degradation under gastric conditions.	Lactose	78-85	galactosidase beta 1	Homo sapiens	0-18
32254972-3	2018	Once the particles are transferred to simulated intestinal conditions, the digestion of phosphatidylcholine with pancreatin led to the release of functional beta-galactosidase.	Phosphatidylcholines	88-107	galactosidase beta 1	Homo sapiens	157-175
30373877-7	2018	Cellular senescence is associated with shortening of telomeres and decreased activity of telomerase, and exposure of cultured endothelial cells to homocysteine causes cellular senescence, shortened telomeres, and increased acidic beta-galactosidase, a marker of cellular senescence.	Homocysteine	147-159	galactosidase beta 1	Homo sapiens	230-248
29421315-3	2018	The activities of alpha-fucosidase, beta-galactosidase, beta-glucuronidase and alpha-mannosidase were determined by colorimetric method and expressed in pKat/mug of creatine (pKat/mug Cr.).	Creatine	165-173	galactosidase beta 1	Homo sapiens	36-54
29989110-2	2018	Enzymatic hydrolysis of the lactose moiety using beta-galactosidase allowed a gel-to-sol phase transition of the supramolecular hydrogel.	Lactose	28-35	galactosidase beta 1	Homo sapiens	49-67
29954182-8	2018	The stability of the enzyme at 37  C under gastric and neutral pH conditions was tested and led to the conclusion that the cross-linked microgels could be suitable for use in food-industry, where beta-Gal carriers are of interest for hydrolyzing lactose in milk products.	Lactose	246-253	galactosidase beta 1	Homo sapiens	196-204
29784356-6	2018	To be specific, firstly SA-beta-gal was conjugated to biotin-labeled AFP antibody, and then the unbounded signal tag in the reaction solution was taken out for digital detection with droplet-based microfluidic.	Biotin	54-60	galactosidase beta 1	Homo sapiens	27-35
29992759-3	2018	Kallistatin inhibited H2 O2 -induced senescence in human endothelial cells, as indicated by reduced senescence-associated-beta-galactosidase activity, p16INK4a and plasminogen activator inhibitor-1 expression, and elevated telomerase activity.	Hydrogen Peroxide	22-27	galactosidase beta 1	Homo sapiens	122-140
29784356-2	2018	The beta-Gal was quantified according to the Poisson Distribution in digital analysis with droplets containing beta-Gal and fluorogenic substrate fluorescein di-beta-D-galactopyranoside (FDG).	fluorescein-digalactoside	146-185	galactosidase beta 1	Homo sapiens	4-12
29784356-2	2018	The beta-Gal was quantified according to the Poisson Distribution in digital analysis with droplets containing beta-Gal and fluorogenic substrate fluorescein di-beta-D-galactopyranoside (FDG).	fluorescein-digalactoside	187-190	galactosidase beta 1	Homo sapiens	4-12
29649531-2	2018	In this work, beta-gal loaded beta-chitosan (CS) nanoparticles (NPs) were successfully prepared based on ionic gelation technique and electrostatic attraction for improving its EE and in vitro releasing capacity.	beta-chitosan	30-43	galactosidase beta 1	Homo sapiens	14-22
29649531-2	2018	In this work, beta-gal loaded beta-chitosan (CS) nanoparticles (NPs) were successfully prepared based on ionic gelation technique and electrostatic attraction for improving its EE and in vitro releasing capacity.	Cesium	45-47	galactosidase beta 1	Homo sapiens	14-22
29649531-3	2018	The particle size of beta-gal loaded low and high molecular weight (LMW and HMW) beta-CS NPs reached 584.37 and 652.46nm, with Zeta-potential (ZP) of 26.37 and 16.46mV under the optimal conditions, respectively.	beta-cs	81-88	galactosidase beta 1	Homo sapiens	21-29
29649531-4	2018	In vitro release study conducted at pH4.5 and 7.4 showed that beta-gal loaded LMW and HMW beta-CS NPs with EE of 68.32 and 58.64% sustained the release of the beta-gal over 12h.	2-(4-Amino-N-ethylanilino)ethanol	78-81	galactosidase beta 1	Homo sapiens	62-70
29649531-4	2018	In vitro release study conducted at pH4.5 and 7.4 showed that beta-gal loaded LMW and HMW beta-CS NPs with EE of 68.32 and 58.64% sustained the release of the beta-gal over 12h.	2-(4-Amino-N-ethylanilino)ethanol	78-81	galactosidase beta 1	Homo sapiens	159-167
29649531-4	2018	In vitro release study conducted at pH4.5 and 7.4 showed that beta-gal loaded LMW and HMW beta-CS NPs with EE of 68.32 and 58.64% sustained the release of the beta-gal over 12h.	beta-cs	90-97	galactosidase beta 1	Homo sapiens	62-70
29649531-4	2018	In vitro release study conducted at pH4.5 and 7.4 showed that beta-gal loaded LMW and HMW beta-CS NPs with EE of 68.32 and 58.64% sustained the release of the beta-gal over 12h.	beta-cs	90-97	galactosidase beta 1	Homo sapiens	159-167
29649531-5	2018	The beta-gal incorporated into beta-CS NPs was confirmed with the results of physicochemical and structural properties of beta-gal loaded beta-CS NPs, and prepared NPs had hardly any cytotoxicity in the range of 0.1-1.0mg/mL.	beta-cs	31-38	galactosidase beta 1	Homo sapiens	4-12
29649531-5	2018	The beta-gal incorporated into beta-CS NPs was confirmed with the results of physicochemical and structural properties of beta-gal loaded beta-CS NPs, and prepared NPs had hardly any cytotoxicity in the range of 0.1-1.0mg/mL.	beta-cs	31-38	galactosidase beta 1	Homo sapiens	122-130
29649531-5	2018	The beta-gal incorporated into beta-CS NPs was confirmed with the results of physicochemical and structural properties of beta-gal loaded beta-CS NPs, and prepared NPs had hardly any cytotoxicity in the range of 0.1-1.0mg/mL.	beta-cs	138-145	galactosidase beta 1	Homo sapiens	4-12
29649531-5	2018	The beta-gal incorporated into beta-CS NPs was confirmed with the results of physicochemical and structural properties of beta-gal loaded beta-CS NPs, and prepared NPs had hardly any cytotoxicity in the range of 0.1-1.0mg/mL.	beta-cs	138-145	galactosidase beta 1	Homo sapiens	122-130
29649531-6	2018	The results indicated that beta-gal loaded beta-CS NPs could serve as non-toxic delivery carriers for the treatment of lactose intolerance.	beta-cs	43-50	galactosidase beta 1	Homo sapiens	27-35
29649531-6	2018	The results indicated that beta-gal loaded beta-CS NPs could serve as non-toxic delivery carriers for the treatment of lactose intolerance.	Lactose	119-126	galactosidase beta 1	Homo sapiens	27-35
30094186-1	2018	Morquio B disease (MBD) or Mucopolysaccharidosis type IV B (MPS IV B) is caused by particular GLB1 mutations specifically affecting the affinity of beta-galactosidase to keratan sulphate, resulting in dysostosis multiplex resembling Morquio A (MPS IV A) disease (GALNS deficiency).	Keratan Sulfate	170-186	galactosidase beta 1	Homo sapiens	94-98
29786931-4	2018	As a representative model, we prepared a prodrug from the chemotherapeutic monomethyl auristatin E, which was modified for activation by beta-galactosidase.	monomethyl auristatin E	75-98	galactosidase beta 1	Homo sapiens	137-155
30094186-1	2018	Morquio B disease (MBD) or Mucopolysaccharidosis type IV B (MPS IV B) is caused by particular GLB1 mutations specifically affecting the affinity of beta-galactosidase to keratan sulphate, resulting in dysostosis multiplex resembling Morquio A (MPS IV A) disease (GALNS deficiency).	Keratan Sulfate	170-186	galactosidase beta 1	Homo sapiens	148-166
29925967-5	2018	The highest level of beta-galactosidase gene expression (10.07 x 10-3 +- 0.09 x 10-3 U/mL) was obtained following treatment of B16F10-Luc cells with G4-dendrimer PEGylated with PEG2K at a dendrimer: DNA ratio of 20:1.	peg2	177-181	galactosidase beta 1	Homo sapiens	21-39
29988039-9	2018	In addition, GSH depletion induced SIPS, as evidenced by increased percentage of the senescence-associated beta-galactosidase-positive cells, increased senescence-associated heterochromatin foci (SAHF), as well as cell cycle arrest at the G1 phase.	Glutathione	13-16	galactosidase beta 1	Homo sapiens	107-125
29596893-13	2018	In addition, all CPA cases examined were positive for senescence-associated beta-galactosidase.	cpa	17-20	galactosidase beta 1	Homo sapiens	76-94
29427610-2	2018	Here, we found that DTBP induces senescence in human gastric adenocarcinoma AGS cells as evidenced by upregulation of p21 and Rb and increased beta-galactosidase activity.	2,4-di-tert-butylphenol	20-24	galactosidase beta 1	Homo sapiens	143-161
29799197-1	2018	Bivalent DNA conjugates of beta-galactosidase (betaGal), having pairs of oligonucleotides positioned closely on opposing faces of the protein, have been synthesized and characterized.	Oligonucleotides	73-89	galactosidase beta 1	Homo sapiens	27-45
29799197-1	2018	Bivalent DNA conjugates of beta-galactosidase (betaGal), having pairs of oligonucleotides positioned closely on opposing faces of the protein, have been synthesized and characterized.	Oligonucleotides	73-89	galactosidase beta 1	Homo sapiens	47-54
29754312-5	2018	The addition of Mg2+-ions decreased the activity of the beta-galactosidase, whereas other metal ions or EDTA showed no inhibitory effect.	magnesium ion	16-20	galactosidase beta 1	Homo sapiens	56-74
29754826-3	2018	These advances enable determination of a cryo-EM density map for beta-galactosidase bound to the inhibitor phenylethyl beta-D-thiogalactopyranoside where the ordered regions are resolved at a level of detail seen in X-ray maps at ~ 1.5 A resolution.	2-Phenylethyl 1-Thio-Beta-D-Galactopyranoside	107-147	galactosidase beta 1	Homo sapiens	65-83
29439846-1	2018	BACKGROUND: GM1 gangliosidosis is a rare lysosomal storage disorder caused by GLB1 mutations.	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	78-82
29439846-4	2018	METHODS: We confirmed a diagnosis of GM1 gangliosidosis based on GLB1 mutations and/or the deficiency of beta-galactosidase activity.	G(M1) Ganglioside	37-40	galactosidase beta 1	Homo sapiens	65-69
33350129-1	2018	Galactooligosaccharides (GOS) are synthesized by the enzyme beta-galactosidase during the hydrolysis of lactose.	galactooligosaccharides	0-23	galactosidase beta 1	Homo sapiens	60-78
29396849-8	2018	Further, we investigated the phenotype severity of known disease-causing mutations of the GLB1 gene, which lead to 2 LSDs (GM1 gangliosidosis and Morquio disease type B).	G(M1) Ganglioside	123-126	galactosidase beta 1	Homo sapiens	90-94
33350129-1	2018	Galactooligosaccharides (GOS) are synthesized by the enzyme beta-galactosidase during the hydrolysis of lactose.	D-Glucitol-1,6-bisphosphate	25-28	galactosidase beta 1	Homo sapiens	60-78
33350129-1	2018	Galactooligosaccharides (GOS) are synthesized by the enzyme beta-galactosidase during the hydrolysis of lactose.	Lactose	104-111	galactosidase beta 1	Homo sapiens	60-78
29315935-4	2018	Here, we report molecular dynamics (MD) simulations of a solvated beta-galactosidase monomer, which illustrate how a water molecule located at the pi face of an indole side chain of tryptophan can adapt to the position of proximate residues and "select" its binding mode.	Water	117-122	galactosidase beta 1	Homo sapiens	66-84
29550585-6	2018	Moreover, when HPMCs subjected to the malignant ascites were protected against oxidative stress with a spin-trap scavenger of reactive oxygen species, they displayed decreased expression of senescence-associated beta-galactosidase and their potential to stimulate cancer cell adhesion, proliferation, and migration was significantly diminished.	Reactive Oxygen Species	126-149	galactosidase beta 1	Homo sapiens	212-230
29315935-4	2018	Here, we report molecular dynamics (MD) simulations of a solvated beta-galactosidase monomer, which illustrate how a water molecule located at the pi face of an indole side chain of tryptophan can adapt to the position of proximate residues and "select" its binding mode.	Tryptophan	182-192	galactosidase beta 1	Homo sapiens	66-84
28801702-5	2018	In this study, we first established a senescent human fetal lung fibroblast MRC-5 cell model using hydrogen peroxide evaluated by senescence-associated beta-galactosidase assay.	Hydrogen Peroxide	99-116	galactosidase beta 1	Homo sapiens	152-170
32254437-2	2018	We now report the detection and assay of two biologically important enzymes, alkaline phosphatase and beta-galactosidase, in Eu- or Tb-based cholate hydrogels, respectively, and on filter paper discs coated with such hydrogels.	Terbium	132-134	galactosidase beta 1	Homo sapiens	102-120
32254437-2	2018	We now report the detection and assay of two biologically important enzymes, alkaline phosphatase and beta-galactosidase, in Eu- or Tb-based cholate hydrogels, respectively, and on filter paper discs coated with such hydrogels.	Cholates	141-148	galactosidase beta 1	Homo sapiens	102-120
29255925-6	2018	Senescence-associated beta galactosidase activity was also measured in CD8+ T cells using flow cytometry with 5-dodecanoylaminofluorescein di-beta-D-galactopyranoside.	5-dodecanoylaminofluorescein di-beta-d-galactopyranoside	110-166	galactosidase beta 1	Homo sapiens	22-40
29444596-4	2018	Our findings demonstrate that agonist arachidonyl-2-chloroethylamidedecreased senescence-associated beta-galactosidase activity and cell cycle arrest in the G0/G1 phase induced by interleukin-1beta.	arachidonyl-2-chloroethylamidedecreased	38-77	galactosidase beta 1	Homo sapiens	100-118
28905280-0	2018	Enzymatic synthesis of fucose-containing galacto-oligosaccharides using beta-galactosidase and identification of novel disaccharide structures.	Fucose	23-29	galactosidase beta 1	Homo sapiens	72-90
28905280-0	2018	Enzymatic synthesis of fucose-containing galacto-oligosaccharides using beta-galactosidase and identification of novel disaccharide structures.	galacto-oligosaccharides	41-65	galactosidase beta 1	Homo sapiens	72-90
28905280-2	2018	This study employed a commercial beta-galactosidase in the production of fucose-containing galacto-oligosaccharides (fGOS) from lactose and fucose.	Fucose	73-79	galactosidase beta 1	Homo sapiens	33-51
28905280-2	2018	This study employed a commercial beta-galactosidase in the production of fucose-containing galacto-oligosaccharides (fGOS) from lactose and fucose.	galacto-oligosaccharides	91-115	galactosidase beta 1	Homo sapiens	33-51
28905280-2	2018	This study employed a commercial beta-galactosidase in the production of fucose-containing galacto-oligosaccharides (fGOS) from lactose and fucose.	fgos	117-121	galactosidase beta 1	Homo sapiens	33-51
28905280-2	2018	This study employed a commercial beta-galactosidase in the production of fucose-containing galacto-oligosaccharides (fGOS) from lactose and fucose.	Lactose	128-135	galactosidase beta 1	Homo sapiens	33-51
28905280-2	2018	This study employed a commercial beta-galactosidase in the production of fucose-containing galacto-oligosaccharides (fGOS) from lactose and fucose.	Fucose	140-146	galactosidase beta 1	Homo sapiens	33-51
28107614-8	2018	After exposure to 100 mum H2 O2 , fewer senescence-associated beta-galactosidase-positive cells were observed on DECM than those on TCPS (17.6  +-  4.0% vs. 60.4  +-  6.2%).	Hydrogen Peroxide	26-31	galactosidase beta 1	Homo sapiens	62-80
29579543-5	2018	First of all, the senescent cells and the cells aged by H2O2 showed higher level of SA-beta-galactosidase staining than young cells.	Hydrogen Peroxide	56-60	galactosidase beta 1	Homo sapiens	87-105
28521673-1	2018	BACKGROUND: Lactose intolerance is characterized by the absence of the enzyme lactase (beta-galactosidase) and affects two thirds of the world adult population.	Lactose	12-19	galactosidase beta 1	Homo sapiens	87-105
29235592-3	2018	Here we use an engineered beta-galactosidase that can be chemically immobilized on a surface with a well-defined orientation through unique surface-accessible cysteine residues.	Cysteine	159-167	galactosidase beta 1	Homo sapiens	26-44
29434841-8	2018	In addition, A172 cells treated with SB exhibited positivity for senescence-associated (SA) beta-galactosidase (gal) staining and elevated protein expression of p53 and p21 in a time- and dose-dependent manner, whereas the expression of p21 mRNA decreased.	Butyric Acid	37-39	galactosidase beta 1	Homo sapiens	92-110
29348392-4	2018	The senescence-associated beta-galactosidase activity, the protein expression of P16 and P21, and inflammatory-related marker gene levels IL-1beta, IL-6, and TNF-alpha were increased in bleomycin-treated AFSCs in a dose-dependent manner.	Bleomycin	186-195	galactosidase beta 1	Homo sapiens	26-44
29235592-5	2018	Two beta-galactosidase variants that were immobilized through cysteine introduced at positions 227 and 308 were studied.	Cysteine	62-70	galactosidase beta 1	Homo sapiens	4-22
29203451-3	2018	A colorimetric beta-galactosidase substrate, chlorophenol-red beta-d-galactopyranoside (CPRG), was used to detect enzymatic activity.	chlorophenol red galactopyranoside	45-86	galactosidase beta 1	Homo sapiens	15-33
29053388-7	2018	The cells treated with 5-FU or IRINO exhibited several hallmarks of SIPS: growth arrest, increased size and granularity, polyploidization, augmented activity of the SA-beta-galactosidase, accumulation of P21 and CYCLIN D1 proteins, and the senescence-associated secretory phenotype.	Fluorouracil	23-27	galactosidase beta 1	Homo sapiens	168-186
30025493-4	2018	Approximately 60% of GBM cells became senescent after treatment with FKB as assessed in the senescence-associated (SA)-GLB1/SA-beta-galactosidase assay.	flavokawain B	69-72	galactosidase beta 1	Homo sapiens	119-123
30025493-4	2018	Approximately 60% of GBM cells became senescent after treatment with FKB as assessed in the senescence-associated (SA)-GLB1/SA-beta-galactosidase assay.	flavokawain B	69-72	galactosidase beta 1	Homo sapiens	127-145
29203451-3	2018	A colorimetric beta-galactosidase substrate, chlorophenol-red beta-d-galactopyranoside (CPRG), was used to detect enzymatic activity.	chlorophenol red galactopyranoside	88-92	galactosidase beta 1	Homo sapiens	15-33
29203451-9	2018	RESULTS: An increased CPRG substrate concentration combined with a different detergent, Saponin, and an optimal wavelength recording markedly increased the sensitivity for the detection of beta-galactosidase activity ( 4-fold increase).	Saponins	88-95	galactosidase beta 1	Homo sapiens	189-207
28795570-6	2017	To allow versatile and sensitive beta-galactosidase (LacZ) based readout we produce autolysates with no detectable background LacZ activity and use them to produce sensitive mercury(II) biosensors with LacZ-mediated colorimetric and fluorescent outputs.	Mercuric cation	174-185	galactosidase beta 1	Homo sapiens	33-51
29473800-3	2018	A LacZ gene-containing E. coli strain that is capable of producing beta-galactosidase enzyme was induced by isopropyl beta-D-1-thiogalactopyranoside with concomitant treatment with test chemicals.	Isopropyl Thiogalactoside	108-148	galactosidase beta 1	Homo sapiens	67-85
29473800-4	2018	After 6-hr incubation, cells were lysed and beta-galactosidase enzyme activity was monitored colorimetrically by using O-nitrophenyl-D-galactopyranoside as a substrate.	o-nitrophenyl-d-galactopyranoside	119-152	galactosidase beta 1	Homo sapiens	44-62
28733703-5	2017	Senescence-associated-beta-galactosidase activity was increased by peloruside A, similar to paclitaxel, discodermolde, and doxorubicin, with a potency heirarchy of doxorubicin &gt; paclitaxel &gt; discodermolide &gt; peloruside, based on IC25 concentrations that inhibit proliferation.	peloruside A	67-79	galactosidase beta 1	Homo sapiens	22-40
28733703-5	2017	Senescence-associated-beta-galactosidase activity was increased by peloruside A, similar to paclitaxel, discodermolde, and doxorubicin, with a potency heirarchy of doxorubicin &gt; paclitaxel &gt; discodermolide &gt; peloruside, based on IC25 concentrations that inhibit proliferation.	Paclitaxel	92-102	galactosidase beta 1	Homo sapiens	22-40
28733703-5	2017	Senescence-associated-beta-galactosidase activity was increased by peloruside A, similar to paclitaxel, discodermolde, and doxorubicin, with a potency heirarchy of doxorubicin &gt; paclitaxel &gt; discodermolide &gt; peloruside, based on IC25 concentrations that inhibit proliferation.	Doxorubicin	123-134	galactosidase beta 1	Homo sapiens	22-40
28733703-5	2017	Senescence-associated-beta-galactosidase activity was increased by peloruside A, similar to paclitaxel, discodermolde, and doxorubicin, with a potency heirarchy of doxorubicin &gt; paclitaxel &gt; discodermolide &gt; peloruside, based on IC25 concentrations that inhibit proliferation.	Doxorubicin	164-175	galactosidase beta 1	Homo sapiens	22-40
28733703-5	2017	Senescence-associated-beta-galactosidase activity was increased by peloruside A, similar to paclitaxel, discodermolde, and doxorubicin, with a potency heirarchy of doxorubicin &gt; paclitaxel &gt; discodermolide &gt; peloruside, based on IC25 concentrations that inhibit proliferation.	Paclitaxel	181-191	galactosidase beta 1	Homo sapiens	22-40
28733703-5	2017	Senescence-associated-beta-galactosidase activity was increased by peloruside A, similar to paclitaxel, discodermolde, and doxorubicin, with a potency heirarchy of doxorubicin &gt; paclitaxel &gt; discodermolide &gt; peloruside, based on IC25 concentrations that inhibit proliferation.	discodermolide	197-211	galactosidase beta 1	Homo sapiens	22-40
28733703-5	2017	Senescence-associated-beta-galactosidase activity was increased by peloruside A, similar to paclitaxel, discodermolde, and doxorubicin, with a potency heirarchy of doxorubicin &gt; paclitaxel &gt; discodermolide &gt; peloruside, based on IC25 concentrations that inhibit proliferation.	peloruside	67-77	galactosidase beta 1	Homo sapiens	22-40
29111890-5	2017	PEGPLA polymersomes facilitate delivery of active beta-galactosidase to an in vitro model of GM1 gangliosidosis.	G(M1) Ganglioside	93-96	galactosidase beta 1	Homo sapiens	50-68
28927620-0	2017	Addition of Pullulan to Trehalose Glasses Improves the Stability of beta-Galactosidase at High Moisture Conditions.	pullulan	12-20	galactosidase beta 1	Homo sapiens	68-86
28927620-5	2017	Storage stability testing up to 4 weeks of the model protein beta-galactosidase incorporated in pullulan/trehalose blends showed superior behavior of pure trehalose at 30 C/0% RH, while pullulan/trehalose blends yielded the best stability at 30 C/56% RH.	pullulan	96-104	galactosidase beta 1	Homo sapiens	61-79
28927620-5	2017	Storage stability testing up to 4 weeks of the model protein beta-galactosidase incorporated in pullulan/trehalose blends showed superior behavior of pure trehalose at 30 C/0% RH, while pullulan/trehalose blends yielded the best stability at 30 C/56% RH.	Trehalose	105-114	galactosidase beta 1	Homo sapiens	61-79
28927620-5	2017	Storage stability testing up to 4 weeks of the model protein beta-galactosidase incorporated in pullulan/trehalose blends showed superior behavior of pure trehalose at 30 C/0% RH, while pullulan/trehalose blends yielded the best stability at 30 C/56% RH.	Trehalose	155-164	galactosidase beta 1	Homo sapiens	61-79
28927620-5	2017	Storage stability testing up to 4 weeks of the model protein beta-galactosidase incorporated in pullulan/trehalose blends showed superior behavior of pure trehalose at 30 C/0% RH, while pullulan/trehalose blends yielded the best stability at 30 C/56% RH.	Rhodium	176-178	galactosidase beta 1	Homo sapiens	61-79
28927620-5	2017	Storage stability testing up to 4 weeks of the model protein beta-galactosidase incorporated in pullulan/trehalose blends showed superior behavior of pure trehalose at 30 C/0% RH, while pullulan/trehalose blends yielded the best stability at 30 C/56% RH.	Trehalose	155-164	galactosidase beta 1	Homo sapiens	61-79
28830687-7	2017	Senescence of human disc cells treated with hydrogen peroxide was confirmed by growth arrest, senescence-associated beta-galactosidase activity, gammaH2AX foci, and acquisition of senescence-associated secretory phenotype.	Hydrogen Peroxide	44-61	galactosidase beta 1	Homo sapiens	116-134
28419749-0	2017	Novel 19 F-MRS beta-galactosidase reporter molecules incorporated nitrogen mustard analogues.	Nitrogen	66-74	galactosidase beta 1	Homo sapiens	15-33
28419749-1	2017	In this study, we propose a novel molecular platform-integrated fluorinated antitumor nitrogen mustards for 19 F-MRS assay of beta-galactosidase (beta-gal) activity.	Nitrogen	86-94	galactosidase beta 1	Homo sapiens	126-144
28419749-1	2017	In this study, we propose a novel molecular platform-integrated fluorinated antitumor nitrogen mustards for 19 F-MRS assay of beta-galactosidase (beta-gal) activity.	Nitrogen	86-94	galactosidase beta 1	Homo sapiens	126-134
28419749-3	2017	Among them, 2-fluoro-4-[bis(2"-chloroethyl)amino]phenyl beta-D-galacto-pyranoside 5 was found very sensitive to beta-gal (E801A) in PBS at 37 C with big DeltadeltaF response.	2-fluoro-4-[bis(2"-chloroethyl)amino]phenyl beta-d-galacto-pyranoside	12-81	galactosidase beta 1	Homo sapiens	112-120
28419749-3	2017	Among them, 2-fluoro-4-[bis(2"-chloroethyl)amino]phenyl beta-D-galacto-pyranoside 5 was found very sensitive to beta-gal (E801A) in PBS at 37 C with big DeltadeltaF response.	Lead	132-135	galactosidase beta 1	Homo sapiens	112-120
28419749-3	2017	Among them, 2-fluoro-4-[bis(2"-chloroethyl)amino]phenyl beta-D-galacto-pyranoside 5 was found very sensitive to beta-gal (E801A) in PBS at 37 C with big DeltadeltaF response.	deltadeltaf	153-164	galactosidase beta 1	Homo sapiens	112-120
28929976-1	2017	The experiments reported in this research paper describe the effects of beta-galactosidase enzyme dose and cheese whey amount, on the maximum concentration and yield of galacto-oligosaccahride (GOS) and reaction time.	galacto-oligosaccahride	169-192	galactosidase beta 1	Homo sapiens	72-90
28929976-1	2017	The experiments reported in this research paper describe the effects of beta-galactosidase enzyme dose and cheese whey amount, on the maximum concentration and yield of galacto-oligosaccahride (GOS) and reaction time.	D-Glucitol-1,6-bisphosphate	194-197	galactosidase beta 1	Homo sapiens	72-90
29084133-5	2017	Both phenols were effective in reducing beta-galactosidase-positive cell number and p16 protein expression.	Phenols	5-12	galactosidase beta 1	Homo sapiens	40-58
27048255-6	2017	RESULTS: Treatment with high concentrations of glucose induced GMC senescence accompanied by shortened telomere length and increase of beta-galactosidase staining as well as P53 protein, which was abrogated after application of caveolin-1-siRNA.	Glucose	47-54	galactosidase beta 1	Homo sapiens	135-153
28612507-7	2017	We show here that HIV and meth induce significant senescence of primary human fetal astrocytes, as evaluated by induction of senescence markers (beta-galactosidase and p16INK4A ), senescence-associated morphologic changes, and cell cycle arrest.	Methamphetamine	26-30	galactosidase beta 1	Homo sapiens	145-163
28861993-0	2017	Fabrication of Stable and Luminescent Copper Nanocluster-Based AIE Particles and Their Application in beta-Galactosidase Activity Assay.	Copper	38-44	galactosidase beta 1	Homo sapiens	102-120
28524263-5	2017	Encapsulation by PICsome provides a stability enhancement of enzymes after 24 h incubation at 37  C, which is particularly helpful for maintaining the high effective concentration of beta-galactosidase.	picsome	17-24	galactosidase beta 1	Homo sapiens	183-201
28828425-1	2017	A novel ferrocene-based substrate for the ratiometric electrochemical detection of beta-galactosidase was designed and synthesised.	ferrocene	8-17	galactosidase beta 1	Homo sapiens	83-101
28726964-7	2017	This reactive alkylating agent forms covalent tellurophene bearing conjugates with local nucleophiles, allowing for the quantification of beta-galactosidase activity in individual cells.	Tellurophene	46-58	galactosidase beta 1	Homo sapiens	138-156
28295567-8	2017	These results demonstrated that melatonin reduced a number of beta-galactosidase (SA-betagal)-positive cells, a senescent marker.	Melatonin	32-41	galactosidase beta 1	Homo sapiens	62-80
28524263-6	2017	Moreover, to control the microenvironment inside the nanoreactor, a large amount of dextran, a neutral macromolecule, is encapsulated together with beta-galactosidase in the PICsome.	Dextrans	84-91	galactosidase beta 1	Homo sapiens	148-166
28732539-4	2017	Addition of beta-galactosidase (beta-gal) to these dispersions leads to complete enzyme adsorption and the generation of beta-gal/TiO2 heteroaggregates.	titanium dioxide	130-134	galactosidase beta 1	Homo sapiens	12-20
28732539-4	2017	Addition of beta-galactosidase (beta-gal) to these dispersions leads to complete enzyme adsorption and the generation of beta-gal/TiO2 heteroaggregates.	titanium dioxide	130-134	galactosidase beta 1	Homo sapiens	32-40
28732539-4	2017	Addition of beta-galactosidase (beta-gal) to these dispersions leads to complete enzyme adsorption and the generation of beta-gal/TiO2 heteroaggregates.	titanium dioxide	130-134	galactosidase beta 1	Homo sapiens	12-30
28732539-6	2017	Parallel ATR-IR-spectroscopic characterization of beta-gal/TiO2 heteroaggregates reveals an adsorption-induced decrease of the beta-sheet content and the formation of random structures leading to the deterioration of the active site.	titanium dioxide	59-63	galactosidase beta 1	Homo sapiens	50-58
28678845-5	2017	Single molecules of the biotin-labeled probe were then labeled with streptavidin-beta-galactosidase (SbetaG), the beads were resuspended in a fluorogenic enzyme substrate, loaded into an array of femtoliter wells, and sealed with oil.	Biotin	24-30	galactosidase beta 1	Homo sapiens	81-99
28716012-0	2017	Case reports of juvenile GM1 gangliosidosisis type II caused by mutation in GLB1 gene.	G(M1) Ganglioside	25-28	galactosidase beta 1	Homo sapiens	76-80
28229451-7	2017	Finally, honokiol reduced senescence-associated beta-galactosidase expression in HFF-1.	honokiol	9-17	galactosidase beta 1	Homo sapiens	48-66
27942976-2	2017	In this work, the activity of beta-galactosidase (EC 3.2.1.23), a cell-wall-bound enzyme known to degrade the wall polysaccharides, has been demonstrated to remarkably enhance during senescence-induced loss in photosynthesis in Arabidopsis thaliana.	Polysaccharides	115-130	galactosidase beta 1	Homo sapiens	30-48
28526263-6	2017	Cellular senescence and tau aberrant modification appeared after tau transfection and aggravated by H2O2 insult which detected by beta-galactosidase staining analysis and western blotting analysis.	Hydrogen Peroxide	100-104	galactosidase beta 1	Homo sapiens	130-148
28193420-1	2017	beta-Galactosidase enzymes are used in the dairy industry to convert lactose into galactooligosaccharides (GOS) that are added to infant formula to mimic the molecular sizes and prebiotic functions of human milk oligosaccharides.	Lactose	69-76	galactosidase beta 1	Homo sapiens	0-18
28193420-1	2017	beta-Galactosidase enzymes are used in the dairy industry to convert lactose into galactooligosaccharides (GOS) that are added to infant formula to mimic the molecular sizes and prebiotic functions of human milk oligosaccharides.	galactooligosaccharides	82-105	galactosidase beta 1	Homo sapiens	0-18
28193420-1	2017	beta-Galactosidase enzymes are used in the dairy industry to convert lactose into galactooligosaccharides (GOS) that are added to infant formula to mimic the molecular sizes and prebiotic functions of human milk oligosaccharides.	D-Glucitol-1,6-bisphosphate	107-110	galactosidase beta 1	Homo sapiens	0-18
28193420-1	2017	beta-Galactosidase enzymes are used in the dairy industry to convert lactose into galactooligosaccharides (GOS) that are added to infant formula to mimic the molecular sizes and prebiotic functions of human milk oligosaccharides.	Oligosaccharides	89-105	galactosidase beta 1	Homo sapiens	0-18
28213701-5	2017	Triterpenotids (5-10 microM) caused G0/G1 cell cycle arrest, an increase in p21 levels and SA-beta-galactosidase staining that was accompanied by oxidative stress and DNA damage.	triterpenotids	0-14	galactosidase beta 1	Homo sapiens	94-112
28144742-2	2017	(Bioprocess Biosyst Eng 39:807-814, 2016) have reported "the synthesis and characterization of graphene for the immobilization of beta-galactosidase for improved galacto-oligosaccharide (GOS) production".	D-Glucitol-1,6-bisphosphate	187-190	galactosidase beta 1	Homo sapiens	130-148
28395779-1	2017	A novel near-infrared fluorescent probe for beta-galactosidase has been developed based on a hemicyanine skeleton, which is conjugated with a d-galactose residue via a glycosidic bond.	tetramethylene hemicyanine	93-104	galactosidase beta 1	Homo sapiens	44-62
28395779-1	2017	A novel near-infrared fluorescent probe for beta-galactosidase has been developed based on a hemicyanine skeleton, which is conjugated with a d-galactose residue via a glycosidic bond.	Galactose	142-153	galactosidase beta 1	Homo sapiens	44-62
29029391-3	2017	The results revealed that ginsenoside Rg3 decreased the number of stromal cells positively stained with a senescent cell marker (senescence-associated beta-galactosidase).	Ginsenosides	26-37	galactosidase beta 1	Homo sapiens	151-169
28340718-0	2017	Metal-to-ligand charge-transfer: Applications to visual detection of beta-galactosidase activity and sandwich immunoassay.	Metals	0-5	galactosidase beta 1	Homo sapiens	69-87
28340718-1	2017	In this work, we report a novel use of the distinctive metal-to-ligand charge-transfer (MLCT) absorption properties of the chromogenic Fe(BPDS)34- (BPDS=bathophenanthroline disulfonic acid) reporter for the visual detection of beta-galactosidase (beta-Gal) activity and sandwich immunoassay.	Metals	55-60	galactosidase beta 1	Homo sapiens	227-245
28340718-1	2017	In this work, we report a novel use of the distinctive metal-to-ligand charge-transfer (MLCT) absorption properties of the chromogenic Fe(BPDS)34- (BPDS=bathophenanthroline disulfonic acid) reporter for the visual detection of beta-galactosidase (beta-Gal) activity and sandwich immunoassay.	Metals	55-60	galactosidase beta 1	Homo sapiens	247-255
28340718-1	2017	In this work, we report a novel use of the distinctive metal-to-ligand charge-transfer (MLCT) absorption properties of the chromogenic Fe(BPDS)34- (BPDS=bathophenanthroline disulfonic acid) reporter for the visual detection of beta-galactosidase (beta-Gal) activity and sandwich immunoassay.	bathophenanthroline disulfonic acid	153-188	galactosidase beta 1	Homo sapiens	227-245
28340718-1	2017	In this work, we report a novel use of the distinctive metal-to-ligand charge-transfer (MLCT) absorption properties of the chromogenic Fe(BPDS)34- (BPDS=bathophenanthroline disulfonic acid) reporter for the visual detection of beta-galactosidase (beta-Gal) activity and sandwich immunoassay.	bathophenanthroline disulfonic acid	153-188	galactosidase beta 1	Homo sapiens	247-255
28144742-0	2017	Comment on ""Elucidating the binding efficacy of beta-galactosidase on graphene by docking approach and its potential application in galacto-oligosaccharide production".	Graphite	71-79	galactosidase beta 1	Homo sapiens	49-67
28559606-4	2017	Protein hydrolysate was again hydrolyzed at 30  C with beta-galactosidase at pH 5.5 to hydrolyze lactose.	Lactose	97-104	galactosidase beta 1	Homo sapiens	55-73
28144742-0	2017	Comment on ""Elucidating the binding efficacy of beta-galactosidase on graphene by docking approach and its potential application in galacto-oligosaccharide production".	galacto-oligosaccharide	133-156	galactosidase beta 1	Homo sapiens	49-67
28144742-2	2017	(Bioprocess Biosyst Eng 39:807-814, 2016) have reported "the synthesis and characterization of graphene for the immobilization of beta-galactosidase for improved galacto-oligosaccharide (GOS) production".	Graphite	95-103	galactosidase beta 1	Homo sapiens	130-148
28144742-2	2017	(Bioprocess Biosyst Eng 39:807-814, 2016) have reported "the synthesis and characterization of graphene for the immobilization of beta-galactosidase for improved galacto-oligosaccharide (GOS) production".	galacto-oligosaccharide	162-185	galactosidase beta 1	Homo sapiens	130-148
28383580-0	2017	A selective and light-up fluorescent probe for beta-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative.	tetraphenylethylene	129-148	galactosidase beta 1	Homo sapiens	47-65
28264511-0	2017	Prevention of Bacterial Contamination of a Silica Matrix Containing Entrapped beta-Galactosidase through the Action of Covalently Bound Lysozymes.	Silicon Dioxide	43-49	galactosidase beta 1	Homo sapiens	78-96
28167527-8	2017	Importantly, endo-beta-galactosidase coupled with MALDI-MS allowed these two epitopes, for the first time, to be directly identified on the polylactosamines of N-glycans of SKOV3, IGROV1, OV90, and OVCA433.	polylactosamine	140-156	galactosidase beta 1	Homo sapiens	18-36
28167527-8	2017	Importantly, endo-beta-galactosidase coupled with MALDI-MS allowed these two epitopes, for the first time, to be directly identified on the polylactosamines of N-glycans of SKOV3, IGROV1, OV90, and OVCA433.	n-glycans	160-169	galactosidase beta 1	Homo sapiens	18-36
28301164-0	2017	Effect of Meso vs Macro Size of Hierarchical Porous Silica on the Adsorption and Activity of Immobilized beta-Galactosidase.	Silicon Dioxide	52-58	galactosidase beta 1	Homo sapiens	105-123
28301164-2	2017	Herein, beta-Gal has been entrapped into a meso-macroporous material (average pore size 9 and 200 nm, respectively) prepared by a sol-gel method from a silica precursor and a dispersion of solid lipid nanoparticles in a micelle phase.	Silicon Dioxide	152-158	galactosidase beta 1	Homo sapiens	8-16
28254702-1	2017	Galactose (Gal) is incorporated into cell wall polysaccharides as flowers open, but then is lost because of beta-galactosidase activity as flowers mature and wilt.	Galactose	0-9	galactosidase beta 1	Homo sapiens	108-126
28254702-1	2017	Galactose (Gal) is incorporated into cell wall polysaccharides as flowers open, but then is lost because of beta-galactosidase activity as flowers mature and wilt.	Galactose	0-3	galactosidase beta 1	Homo sapiens	108-126
32263951-0	2017	A universal fluorometric assay strategy for glycosidases based on functional carbon quantum dots: beta-galactosidase activity detection in vitro and in living cells.	Carbon	77-83	galactosidase beta 1	Homo sapiens	98-116
28110172-3	2017	As a model system for in vivo targeted imaging, DCDHF-betagal possessing galactose unit selectively target hepatocyte and monitor the beta-galactosidase activity with deep tissue penetration, and low background interference.	Galactose	73-82	galactosidase beta 1	Homo sapiens	134-152
28193331-0	2017	Colorimetric enumeration of bacterial contamination in water based on beta-galactosidase gold nanoshell activity.	Water	55-60	galactosidase beta 1	Homo sapiens	70-88
28193331-2	2017	The CTAB capped gold nanoshells are electrostatically attracted by both the bacterial surface and the enzyme beta-galactosidase.	Cetrimonium	4-8	galactosidase beta 1	Homo sapiens	109-127
28193331-3	2017	The preferential binding of cationic (CTAB)-functionalized gold nanoshells to the more negative bacterial surfaces leaves active beta-galactosidase in solution, providing an enzyme-amplified colorimetric response of the binding event.	Cetrimonium	38-42	galactosidase beta 1	Homo sapiens	129-147
28286417-11	2017	beta-Galactosidase staining analysis and p16INK4a expression analysis showed that LEE011 treatment can induce cell senescence of leukemia cells.	ribociclib	82-88	galactosidase beta 1	Homo sapiens	0-18
28264511-1	2017	beta-galactosidase was successfully encapsulated within an amino-functionalised silica matrix using a "fish-in-net" approach and molecular imprinting technique followed by covalent binding of lysozyme via a glutaraldehyde-based method.	Silicon Dioxide	80-86	galactosidase beta 1	Homo sapiens	0-18
28264511-1	2017	beta-galactosidase was successfully encapsulated within an amino-functionalised silica matrix using a "fish-in-net" approach and molecular imprinting technique followed by covalent binding of lysozyme via a glutaraldehyde-based method.	Glutaral	207-221	galactosidase beta 1	Homo sapiens	0-18
27718039-13	2017	For both cell lines the mechanisms of tumor suppression involved was senescence, since the combination of 4MU and Imatinib arrested the cell cycle and increased senescence associated beta-galactosidase activity and senescence associated heterochromatin foci presence when compared to each drug alone.	Imatinib Mesylate	114-122	galactosidase beta 1	Homo sapiens	183-201
28234906-2	2017	Senescence is terminal growth arrest in response to cell stress that is characterized by increased lysosomal-beta-galactosidase (GLB1) the origin of senescence associated-beta-gal activity (SA-beta-gal).	beta-D-galactose	109-117	galactosidase beta 1	Homo sapiens	129-133
28234906-2	2017	Senescence is terminal growth arrest in response to cell stress that is characterized by increased lysosomal-beta-galactosidase (GLB1) the origin of senescence associated-beta-gal activity (SA-beta-gal).	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	190-201	galactosidase beta 1	Homo sapiens	129-133
28234906-9	2017	In PC treated with neoadjuvant ADT, GLB1 expression increased in intermediate Gleason score (GS 6-7; p = 0.001), but not high grade (GS 8-10) cancer.	adt	31-34	galactosidase beta 1	Homo sapiens	36-40
28234906-10	2017	Significantly higher levels of GLB1 were seen in tissues undergoing neoadjuvant ADT longer than 5 months compared to untreated tissues (p = 0.002).	adt	80-83	galactosidase beta 1	Homo sapiens	31-35
28234906-12	2017	CONCLUSIONS: Increased GLB1 after neoadjuvant ADT occurs primarily among more clinically favorable intermediate grade cancers and enrichment of the phenotype occurs in a temporally prolonged fashion.	adt	46-49	galactosidase beta 1	Homo sapiens	23-27
27845246-8	2017	The cardiac fibroblast phenotype caused by palmitate, in an LPS and NLRP3 independent manner, was characterized by decreased cellular proliferation, contractility, collagen and MMP-2 expression, as well as increased senescence-associated beta-galactosidase activity, and consistent with a state of cellular senescence.	Palmitates	43-52	galactosidase beta 1	Homo sapiens	238-256
27342764-1	2016	BACKGROUND: Different types of reduced-lactose yogurt, obtained by lactose hydrolysis using beta-galactosidase enzyme, are commercially available.	Lactose	39-46	galactosidase beta 1	Homo sapiens	92-110
27789075-2	2017	The addition of a long alkyl chain, such as decyl or dodecyl, to the nitrogen led to the production of highly potent inhibitors of alpha-l-rhamnosidase; it also caused broad inhibition spectrum against beta-glucosidase and beta-galactosidase.	Nitrogen	69-77	galactosidase beta 1	Homo sapiens	223-241
27514909-4	2017	When a water sample without antibiotics is applied to the paper discs, beta-galactosidase can be synthesized, and it hydrolyzes a colorimetric substrate, resulting in a color change from yellow to purple.	Water	7-12	galactosidase beta 1	Homo sapiens	71-89
27958341-8	2016	Additionally, enhanced cellular senescence, determined by senescence-associated beta-galactosidase staining, was obviously attenuated by p38-MAPK inhibitor SB203580.	SB 203580	156-164	galactosidase beta 1	Homo sapiens	80-98
27750150-0	2017	(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal beta-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.	(5aR)-5a-C-pentyl-4-epi-isofagomine	0-35	galactosidase beta 1	Homo sapiens	71-89
27750150-1	2017	This report is about the identification, synthesis and initial biological characterization of derivatives of 4-epi-isofagomine as pharmacological chaperones (PC) for human lysosomal beta-galactosidase.	isofagomine	109-126	galactosidase beta 1	Homo sapiens	182-200
27750150-3	2017	Both epimers were evaluated as inhibitors of the human beta-galactosidase: the (5aR)-stereoisomer (compound 1) was found to be a very potent inhibitor of the enzyme (IC50 = 8 nM, 30x more potent than 4-epi-isofagomine at pH 7.3) with a high selectivity for this glycosidase whereas the (5aS) epimer was a much weaker inhibitor.	isofagomine	200-217	galactosidase beta 1	Homo sapiens	55-73
28280523-5	2017	Using CuSO4-SIPS WI-38 fibroblasts, resveratrol is shown to attenuate typical senescence alterations on cell morphology, senescence-associated beta-galactosidase activity, and cell proliferation.	Resveratrol	36-47	galactosidase beta 1	Homo sapiens	143-161
27878149-1	2016	We developed a new efficient method for the synthesis of important indoxyl glycoside substrates for beta-glucosidase and beta-galactosidase by using 1-acetylindol-3-ones as intermediates.	indoxyl glycoside	67-84	galactosidase beta 1	Homo sapiens	121-139
27878149-1	2016	We developed a new efficient method for the synthesis of important indoxyl glycoside substrates for beta-glucosidase and beta-galactosidase by using 1-acetylindol-3-ones as intermediates.	1-acetylindol-3-ones	149-169	galactosidase beta 1	Homo sapiens	121-139
27934226-2	2016	We have demonstrated that the beta-galactosidase in the monolayer form remained active and performed hydrolysis of the X-gal in the subphase.	5-bromo-4-chloro-3-indolyl beta-galactoside	119-124	galactosidase beta 1	Homo sapiens	30-48
27342764-1	2016	BACKGROUND: Different types of reduced-lactose yogurt, obtained by lactose hydrolysis using beta-galactosidase enzyme, are commercially available.	Lactose	67-74	galactosidase beta 1	Homo sapiens	92-110
27673450-8	2016	When ASPL-TFE3 was expressed in human bone marrow-derived mesenchymal stem cells in a tetracycline-inducible manner, we observed the up-regulation of p21 expression and the induction of senescence-associated beta-galactosidase activity.	Tetracycline	86-98	galactosidase beta 1	Homo sapiens	208-226
26970021-5	2016	In addition, part of N-acetyl-beta-D-glucosaminidase, beta-galactosidase, and beta-glucuronidase can also be released by mannose-6-phosphate.	mannose-6-phosphate	121-140	galactosidase beta 1	Homo sapiens	54-72
27531889-4	2016	In this study, we constructed two doxycycline-inducing KLF4 cell models, and demonstrated overexpression of KLF4 could promote cell senescence, detected by senescence-associated beta-galactosidase activity assay.	Doxycycline	34-45	galactosidase beta 1	Homo sapiens	178-196
27295070-6	2016	Delivered beta-galactosidase, inactive within the MC complex, became enzymatically active within cells to convert a prodrug.	Methylcholanthrene	50-52	galactosidase beta 1	Homo sapiens	10-28
27305312-6	2016	The enzyme was efficiently labeled with biotin, and the kinetic data for the biotinylated enzyme were comparable to those for unlabeled beta-galactosidase.	Biotin	40-46	galactosidase beta 1	Homo sapiens	136-154
27093475-7	2016	Moreover, CS extract induced cellular senescence in cultured human airway epithelial cells, represented by induced senescence-associated beta-galactosidase activity, inhibited cell proliferation, increased p21 expression, and increased release of high-mobility group box 1 and IL-6.	Cesium	10-12	galactosidase beta 1	Homo sapiens	137-155
27237816-12	2016	In CSE stimulated bronchial epithelial cells carbocysteine reverted these phenomena by increasing cell proliferation, and SIRT1 and FoxO3 nuclear expression, and by reducing beta galactosidase staining and survivin expression.	Carbocysteine	45-58	galactosidase beta 1	Homo sapiens	174-192
27477846-7	2016	This concentration gradually decreased, and H2was almost undetectable in medium after 12 h. At 24 h after TCDD exposure, HUVECs treated with TCDD exhibited increased 8OHdG and acetyl-p53 expression, decreased nicotinamide adenine dinucleotide (NAD(+))/NADH ratio, impaired Sirt1 activity, and enhanced senescence-associated beta-galactosidase.	Polychlorinated Dibenzodioxins	141-145	galactosidase beta 1	Homo sapiens	324-342
27063389-0	2016	Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable beta-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal beta-galactosidase mutant R201C.	isofagomine	45-62	galactosidase beta 1	Homo sapiens	72-90
27063389-0	2016	Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable beta-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal beta-galactosidase mutant R201C.	isofagomine	45-62	galactosidase beta 1	Homo sapiens	171-189
27036870-9	2016	Treatment with the concentration of 27-OHC detected in COPD airways significantly augmented expression of senescence-associated proteins and senescence-associated beta-galactosidase activity, and delayed cell growth through the prostaglandin E2-reactive nitrogen species pathway.	27-hydroxycholesterol	36-42	galactosidase beta 1	Homo sapiens	163-181
26830562-0	2016	Encapsulation of lactase (beta-galactosidase) into kappa-carrageenan-based hydrogel beads: Impact of environmental conditions on enzyme activity.	Carrageenan	51-68	galactosidase beta 1	Homo sapiens	26-44
26830562-2	2016	In this study, the potential of carrageenan hydrogel beads for encapsulating beta-galactosidase was investigated.	Carrageenan	32-43	galactosidase beta 1	Homo sapiens	77-95
27018312-2	2016	The capabilities of the technology are examined in a comprehensive analysis of the effects of a variety of diverse factors on the performance of enzyme beta-galactosidase in formulations for reduction of levels of lactose in infant milks.	Lactose	214-221	galactosidase beta 1	Homo sapiens	152-170
27174424-3	2016	beta-Gal and GOx are assembled on two separated gold films patterned in a polydimethylsiloxane (PDMS) microchannel with a controllable distance from 50 to 100 mum.	baysilon	74-94	galactosidase beta 1	Homo sapiens	0-8
27174424-3	2016	beta-Gal and GOx are assembled on two separated gold films patterned in a polydimethylsiloxane (PDMS) microchannel with a controllable distance from 50 to 100 mum.	baysilon	96-100	galactosidase beta 1	Homo sapiens	0-8
27054782-3	2016	DCM-betagal manifests significantly ratiometric and turn-on NIR fluorescent signals simultaneously in response to beta-gal concentration, which makes it favorable for monitoring dynamic beta-gal activity in vivo with self-calibration in fluorescent mode.	dcm	0-3	galactosidase beta 1	Homo sapiens	114-122
26210997-7	2016	The activity of SA-beta-galactosidase and the expression of senescence proteins p53 and p16 were reduced in RG108-treated ALS-MSCs.	RG108	108-113	galactosidase beta 1	Homo sapiens	19-37
26861556-0	2016	Elucidating the binding efficacy of beta-galactosidase on graphene by docking approach and its potential application in galacto-oligosaccharide production.	Graphite	58-66	galactosidase beta 1	Homo sapiens	36-54
26861556-0	2016	Elucidating the binding efficacy of beta-galactosidase on graphene by docking approach and its potential application in galacto-oligosaccharide production.	galacto-oligosaccharide	120-143	galactosidase beta 1	Homo sapiens	36-54
26861556-1	2016	Herein, we propose the synthesis and characterization of graphene for the immobilization of beta-galactosidase for improved galacto-oligosaccharide (GOS) production.	Graphite	57-65	galactosidase beta 1	Homo sapiens	92-110
26861556-1	2016	Herein, we propose the synthesis and characterization of graphene for the immobilization of beta-galactosidase for improved galacto-oligosaccharide (GOS) production.	galacto-oligosaccharide	124-147	galactosidase beta 1	Homo sapiens	92-110
26861556-1	2016	Herein, we propose the synthesis and characterization of graphene for the immobilization of beta-galactosidase for improved galacto-oligosaccharide (GOS) production.	D-Glucitol-1,6-bisphosphate	149-152	galactosidase beta 1	Homo sapiens	92-110
26420897-10	2016	The VEGFR-selective tyrosine kinase inhibitor cediranib decreased tumor DNA synthesis, increased staining for senescence-associated beta-galactosidase, reduced retinoblastoma phosphorylation, and increased p27(Kip1), all markers of cellular senescence.	cediranib	46-55	galactosidase beta 1	Homo sapiens	132-150
27054782-3	2016	DCM-betagal manifests significantly ratiometric and turn-on NIR fluorescent signals simultaneously in response to beta-gal concentration, which makes it favorable for monitoring dynamic beta-gal activity in vivo with self-calibration in fluorescent mode.	dcm	0-3	galactosidase beta 1	Homo sapiens	186-194
27054782-4	2016	We exemplify DCM-betagal for the ratiometric tracking of endogenously overexpressed beta-gal distribution in living 293T cells via the lacZ gene transfection method and OVCAR-3 cells, and further realize real-time in vivo bioimaging of beta-gal activity in colorectal tumor-bearing nude mice.	dcm-betagal	13-24	galactosidase beta 1	Homo sapiens	84-92
27054782-4	2016	We exemplify DCM-betagal for the ratiometric tracking of endogenously overexpressed beta-gal distribution in living 293T cells via the lacZ gene transfection method and OVCAR-3 cells, and further realize real-time in vivo bioimaging of beta-gal activity in colorectal tumor-bearing nude mice.	dcm-betagal	13-24	galactosidase beta 1	Homo sapiens	236-244
26818323-8	2016	Quantitative analysis revealed that the beta-galactosidase activity within cells exposed to tetracycline increased 181-fold at 48 hours (p &lt; 0.001) and 47-fold at 72 hours after infection (p &lt; 0.05) compared with those without tetracycline.	Tetracycline	92-104	galactosidase beta 1	Homo sapiens	40-58
26838810-0	2016	Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful beta-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal beta-galactosidase.	isofagomine	48-65	galactosidase beta 1	Homo sapiens	76-94
26838810-0	2016	Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful beta-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal beta-galactosidase.	isofagomine	48-65	galactosidase beta 1	Homo sapiens	185-203
26827776-2	2016	Functionalized dendrimer-like hierarchically porous silica nanoparticles (HPSNs) was fabricated for assembling beta-galactosidase nanobiocatalysts for bioconversion of lactose to galacto-oligosaccharides (GOS).	Silicon Dioxide	52-58	galactosidase beta 1	Homo sapiens	111-129
26827776-2	2016	Functionalized dendrimer-like hierarchically porous silica nanoparticles (HPSNs) was fabricated for assembling beta-galactosidase nanobiocatalysts for bioconversion of lactose to galacto-oligosaccharides (GOS).	Lactose	168-175	galactosidase beta 1	Homo sapiens	111-129
26827776-2	2016	Functionalized dendrimer-like hierarchically porous silica nanoparticles (HPSNs) was fabricated for assembling beta-galactosidase nanobiocatalysts for bioconversion of lactose to galacto-oligosaccharides (GOS).	galacto-oligosaccharides	179-203	galactosidase beta 1	Homo sapiens	111-129
26827776-2	2016	Functionalized dendrimer-like hierarchically porous silica nanoparticles (HPSNs) was fabricated for assembling beta-galactosidase nanobiocatalysts for bioconversion of lactose to galacto-oligosaccharides (GOS).	D-Glucitol-1,6-bisphosphate	205-208	galactosidase beta 1	Homo sapiens	111-129
26827776-10	2016	Our research findings show the amino-functionalized HPSNs can selectively promote the enzyme activity of beta-galactosidase for transgalactosylation, which is beneficial for GOS production.	D-Glucitol-1,6-bisphosphate	174-177	galactosidase beta 1	Homo sapiens	105-123
26112901-1	2016	AIM: The purposes of this study were to investigate senescence-associated beta-galactosidase (SA-beta-Gal) levels in articular cartilage of knee osteoarthritis (OA) and the relationship with severity of the disease.	beta-D-galactose	97-105	galactosidase beta 1	Homo sapiens	74-92
26730435-7	2016	In SW620 cell line, 37.5% giant multinucleated cells induced by FLU treatment showed positivity for SA-beta-galactosidase staining.	flubendazole	64-67	galactosidase beta 1	Homo sapiens	103-121
26766614-7	2016	Purified proteins representing both fusion orientations were efficiently taken up into GM1 patient fibroblasts and mediated the reduction of GM1 ganglioside substrate with activities matching mammalian cell-derived beta-galactosidase.	G(M1) Ganglioside	141-156	galactosidase beta 1	Homo sapiens	215-233
26875935-3	2016	However, beta-glycosidases are not known to play a role in N- and O-glycan processing, although both glycans provide partial structures as substrates for beta-galactosidase and beta-N-acetylglucosaminidase in the Golgi apparatus of human cells.	Polysaccharides	101-108	galactosidase beta 1	Homo sapiens	154-172
26875935-4	2016	We explored human Golgi beta-galactosidase using fluorescent substrates based on a quinone methide cleavage (QMC) substrate design platform that was previously developed to image exo-type glycosidases in living cells.	qmc	109-112	galactosidase beta 1	Homo sapiens	24-42
26875935-6	2016	It is possible to predict a novel and important function in glycan processing of this beta-galactosidase, because various beta-galactosyl linkages in N- and O-glycans exist in Golgi apparatus.	Polysaccharides	60-66	galactosidase beta 1	Homo sapiens	86-104
26875935-6	2016	It is possible to predict a novel and important function in glycan processing of this beta-galactosidase, because various beta-galactosyl linkages in N- and O-glycans exist in Golgi apparatus.	n- and o-glycans	150-166	galactosidase beta 1	Homo sapiens	86-104
26794530-7	2016	Moreover, GSK461364 exerted a cytotoxic effect by inducing apoptosis in OS, and induced cellular senescence in OS cell lines, as indicated by an increased senescence-associated beta-galactosidase activity and enhanced DcR2 and interleukin-1alpha expression.	GSK 461364	10-19	galactosidase beta 1	Homo sapiens	177-195
26460847-9	2016	Moreover, senescence-associated beta-galactosidase staining showed that in response to boanmycin, there were 90% senescence cells in IMR90 and 95% in OBs.	bleomycin A6	87-96	galactosidase beta 1	Homo sapiens	32-50
26259553-4	2016	OBJECTIVES: The aim of this study was to determine the chaperone effect of N-octyl-4-epi-beta-valienamine (NOEV) on beta-gal proteins in skin fibroblasts of PPCA-deficit patients.	N-octyl-beta-valienamine	75-105	galactosidase beta 1	Homo sapiens	116-124
26818323-8	2016	Quantitative analysis revealed that the beta-galactosidase activity within cells exposed to tetracycline increased 181-fold at 48 hours (p &lt; 0.001) and 47-fold at 72 hours after infection (p &lt; 0.05) compared with those without tetracycline.	Tetracycline	233-245	galactosidase beta 1	Homo sapiens	40-58
26794644-4	2016	VO-OHpic inhibited cell viability, cell proliferation and colony formation, and induced senescence-associated beta-galactosidase activity in Hep3B (low PTEN expression) and to a lesser extent in PLC/PRF/5 (high PTEN expression) cells, but not in PTEN-negative SNU475 cells.	VO-OHpic	0-8	galactosidase beta 1	Homo sapiens	110-128
26644389-7	2016	In contrast, alkyl substitution at C5 resulted in enhanced beta-galactosidase inhibitory activity by a factor of up to 1000, with at least six carbon atoms in the alkyl substituent.	Carbon	143-149	galactosidase beta 1	Homo sapiens	59-77
26644389-9	2016	Human lysosomal beta-galactosidase from leukocyte lysate was, however, poorly inhibited by all iminoribitol derivatives tested (IC50 values in the 100 muM range), while 4-epi-IFG was a good inhibitor of this enzyme.	IMINORIBITOL	95-107	galactosidase beta 1	Homo sapiens	16-34
26291713-1	2015	When lactose was incubated with G794A-beta-galactosidase (a variant with a "closed" active site loop that binds transition state analogs well) an allolactose was trapped with its Gal moiety in a (4)H3 conformation, similar to the oxocarbenium ion-like conformation expected of the transition state.	Lactose	5-12	galactosidase beta 1	Homo sapiens	38-56
26586589-0	2016	Hydrolysis of whey lactose by immobilized beta-galactosidase in a bioreactor with a spirally wound membrane.	Lactose	19-26	galactosidase beta 1	Homo sapiens	42-60
26586589-1	2016	The beta-galactosidase was covalently immobilized onto a modified polypropylene membrane, using glutaraldehyde.	Polypropylenes	66-79	galactosidase beta 1	Homo sapiens	4-22
26586589-1	2016	The beta-galactosidase was covalently immobilized onto a modified polypropylene membrane, using glutaraldehyde.	Glutaral	96-110	galactosidase beta 1	Homo sapiens	4-22
26586589-2	2016	The optimal conditions for hydrolysis of lactose (4.7%) by immobilized beta-galactosidase in a batch process were determined 13.6 U enzyme activity, 40 C, pH 6.8 and 10h.	Lactose	41-48	galactosidase beta 1	Homo sapiens	71-89
26586589-6	2016	The obtained immobilized system beta-galactosidase/polypropylene membrane was applied to produce glucose-galactose syrup from waste whey.	Polypropylenes	51-64	galactosidase beta 1	Homo sapiens	32-50
27119009-8	2016	EGCG inhibited accumulation of senescence-associated beta-galactosidase but did not affect the loss of proliferative capacity, suggesting that EGCG did not fully neutralize exogenous radicals.	epigallocatechin gallate	0-4	galactosidase beta 1	Homo sapiens	53-71
27159975-7	2016	RESULTS: The greatest levels of beta-galactosidase expression were observed using a DNA:Lipofectamine  ratio of 1:5 (mug/mul) on day 3 after transfection, using culture medium at pH 7, and in the presence of hydrocortisone.	Lipofectamine	88-101	galactosidase beta 1	Homo sapiens	32-50
27159975-7	2016	RESULTS: The greatest levels of beta-galactosidase expression were observed using a DNA:Lipofectamine  ratio of 1:5 (mug/mul) on day 3 after transfection, using culture medium at pH 7, and in the presence of hydrocortisone.	Hydrocortisone	208-222	galactosidase beta 1	Homo sapiens	32-50
26587747-3	2015	The covalent attachment of a shell of oligonucleotides to the surface of beta-galactosidase enhances its cellular uptake of by up to ~280-fold and allows for the use of working concentrations as low as 100 pM enzyme.	Oligonucleotides	38-54	galactosidase beta 1	Homo sapiens	73-91
32263131-1	2015	A novel fluorescent probe SA-betaGal is reported here with light-up response to beta-galactosidase.	sa-betagal	26-36	galactosidase beta 1	Homo sapiens	80-98
32263131-2	2015	SA-betaGal possesses the beta-galactopyranoside group to react with beta-galactosidase and releases the fluorescent salicylaldehyde azine with both aggregation induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	0-2	galactosidase beta 1	Homo sapiens	68-86
32263131-2	2015	SA-betaGal possesses the beta-galactopyranoside group to react with beta-galactosidase and releases the fluorescent salicylaldehyde azine with both aggregation induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics.	beta-galactopyranoside	25-47	galactosidase beta 1	Homo sapiens	68-86
32263131-5	2015	Moreover, thanks to its good retention in living cells, the application of SA-betaGal for the imaging of cellular beta-galactosidase was also achieved with high contrast.	sa-betagal	75-85	galactosidase beta 1	Homo sapiens	114-132
26291713-7	2015	Computational studies of the energy of sugar ring distortion show that the beta-galactosidase reaction itinerary is driven by energetic considerations in utilization of a (4)H3 transition state with a novel (4)C1-(4)H3-(4)C1 conformation itinerary.	Sugars	39-44	galactosidase beta 1	Homo sapiens	75-93
26291713-1	2015	When lactose was incubated with G794A-beta-galactosidase (a variant with a "closed" active site loop that binds transition state analogs well) an allolactose was trapped with its Gal moiety in a (4)H3 conformation, similar to the oxocarbenium ion-like conformation expected of the transition state.	cyclohexenoesculetin-beta-galactoside	179-182	galactosidase beta 1	Homo sapiens	38-56
26291713-1	2015	When lactose was incubated with G794A-beta-galactosidase (a variant with a "closed" active site loop that binds transition state analogs well) an allolactose was trapped with its Gal moiety in a (4)H3 conformation, similar to the oxocarbenium ion-like conformation expected of the transition state.	oxocarbenium	230-242	galactosidase beta 1	Homo sapiens	38-56
26467393-4	2015	Human aortic smooth muscle cells treated with beta-Glycerophosphate (BGP, 10mM) suffered cellular senescence by increasing p53, p21 and p16 expression and the senescence associated beta-galactosidase activity.	beta-glycerophosphoric acid	46-67	galactosidase beta 1	Homo sapiens	181-199
26365722-0	2015	A dendritic beta-galactosidase-responsive folate-monomethylauristatin E conjugate.	Folic Acid	42-48	galactosidase beta 1	Homo sapiens	12-30
25676326-5	2015	Among the isolated compounds, ergosterol peroxide (2) reduced senescence associated beta-galactosidase (SA-beta-gal) activity increased in HUVECs treated with adriamycin.	ergosterol-5,8-peroxide	30-49	galactosidase beta 1	Homo sapiens	84-102
25676326-5	2015	Among the isolated compounds, ergosterol peroxide (2) reduced senescence associated beta-galactosidase (SA-beta-gal) activity increased in HUVECs treated with adriamycin.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	104-115	galactosidase beta 1	Homo sapiens	84-102
25676326-5	2015	Among the isolated compounds, ergosterol peroxide (2) reduced senescence associated beta-galactosidase (SA-beta-gal) activity increased in HUVECs treated with adriamycin.	Doxorubicin	159-169	galactosidase beta 1	Homo sapiens	84-102
26365722-0	2015	A dendritic beta-galactosidase-responsive folate-monomethylauristatin E conjugate.	monomethyl auristatin E	49-71	galactosidase beta 1	Homo sapiens	12-30
25842188-0	2015	Lactose hydrolysis by beta-galactosidase enzyme: optimization using response surface methodology.	Lactose	0-7	galactosidase beta 1	Homo sapiens	22-40
26474283-4	2015	This response leads to G2/M cell cycle arrest and induces a senescent-like phenotype accompanied by enlargement of cells and increased senescence-associated beta-galactosidase activity, which are abrogated by N-acetyl cysteine (NAC) pre-treatment.	Acetylcysteine	209-226	galactosidase beta 1	Homo sapiens	157-175
26474283-4	2015	This response leads to G2/M cell cycle arrest and induces a senescent-like phenotype accompanied by enlargement of cells and increased senescence-associated beta-galactosidase activity, which are abrogated by N-acetyl cysteine (NAC) pre-treatment.	Acetylcysteine	228-231	galactosidase beta 1	Homo sapiens	157-175
25842188-1	2015	In the present study, it was aimed to optimize the process of lactose hydrolysis using free and immobilized beta-galactosidase to produce glucose and galactose.	Lactose	62-69	galactosidase beta 1	Homo sapiens	108-126
25842188-1	2015	In the present study, it was aimed to optimize the process of lactose hydrolysis using free and immobilized beta-galactosidase to produce glucose and galactose.	Glucose	138-145	galactosidase beta 1	Homo sapiens	108-126
25842188-1	2015	In the present study, it was aimed to optimize the process of lactose hydrolysis using free and immobilized beta-galactosidase to produce glucose and galactose.	Galactose	150-159	galactosidase beta 1	Homo sapiens	108-126
26163092-12	2015	A larger population of senescence-activated beta-galactosidase-positive cells was seen in the trametinib pretreated group, and this correlated with activation of two of the major mediators of induced senescence, p53 and pRb.	trametinib	94-104	galactosidase beta 1	Homo sapiens	44-62
26476078-9	2015	Among the found hits, a benzimidazolone compound, CB-20903630, had low micromolar IC50 for growth inhibition of HCT116 cells and selectively induced senescence-associated beta-galactosidase activity in the entire treated cell population without cytotoxicity or apoptosis induction.	benzimidazolone	24-39	galactosidase beta 1	Homo sapiens	171-189
27134760-3	2015	In addition, we demonstrate that this device can be used for droplet clustering and real-time analysis by clustering several droplets together into microwells and monitoring diffusion of fluorescein, a product of the enzymatic reaction of beta-galactosidase and its fluorogenic substrate FDG, between droplets.	Fluorescein	187-198	galactosidase beta 1	Homo sapiens	239-257
25655189-4	2015	VSMC senescence was induced by hydrogen peroxide (H(2)O(2)), followed by detection using a senescence-associated beta-galactosidase staining kit.	vsmc	0-4	galactosidase beta 1	Homo sapiens	113-131
26104537-0	2015	Enhancing enzyme stability and metabolic functional ability of beta-galactosidase through functionalized polymer nanofiber immobilization.	Polymers	105-112	galactosidase beta 1	Homo sapiens	63-81
26104537-1	2015	A functionalized polystyrene nanofiber (PSNF) immobilized beta-galactosidase assembly (PSNF-Gal) was synthesized as a nanobiocatalyst aiming to enhance the biocatalyst stability and functional ability.	Polystyrenes	17-28	galactosidase beta 1	Homo sapiens	58-76
26337541-6	2015	Prolonged exposure to H2O2 led to premature cellular senescence, as characterised by the inhibition of proliferation, the enhanced senescence-associated beta galactosidase staining and the over-expression of known molecular markers, without though a significant decrease in the chromosome telomere length.	Hydrogen Peroxide	22-26	galactosidase beta 1	Homo sapiens	153-171
26237524-8	2015	To demonstrate the practical utility of 2-COOH DCTM as a novel scaffold for red fluorescent probes, we employed it to develop a probe for beta-galactosidase.	2-cooh dctm	40-51	galactosidase beta 1	Homo sapiens	138-156
26476078-9	2015	Among the found hits, a benzimidazolone compound, CB-20903630, had low micromolar IC50 for growth inhibition of HCT116 cells and selectively induced senescence-associated beta-galactosidase activity in the entire treated cell population without cytotoxicity or apoptosis induction.	cb-20903630	50-61	galactosidase beta 1	Homo sapiens	171-189
25988728-3	2015	Here, we sought to transplant adipose derived-mesenchymal stem cells (AD-MSCs) with a hydrogel (NapFF-NO), naphthalene covalently conjugated a short peptide, FFGGG, and beta-galactose caged nitric oxide (NO) donor, which can release NO molecule in response to beta-galactosidase.	naphthalene	107-118	galactosidase beta 1	Homo sapiens	260-278
26252905-9	2015	Another cell study demonstrated that beta-galactosidase premixed with polymers was taken up into cells in its active tetrameric form.	Polymers	70-78	galactosidase beta 1	Homo sapiens	37-55
26101788-7	2015	We also demonstrated a dual-color digital enzyme assay with a ALP/4-MUP and beta-galactosidase (beta-gal)/resorufin-beta-d-galactopyranoside combination.	resorufin	106-115	galactosidase beta 1	Homo sapiens	76-94
26101788-7	2015	We also demonstrated a dual-color digital enzyme assay with a ALP/4-MUP and beta-galactosidase (beta-gal)/resorufin-beta-d-galactopyranoside combination.	resorufin	106-115	galactosidase beta 1	Homo sapiens	76-84
26345950-3	2015	Assessments of the expression of the beta-galactosidase enzyme were performed in the presence of menadione (MEN) and phenazine methosulfate (PMS) compounds at different final concentrations to evaluate the heterologous activation of the predicted promoter region of interest in C. violaceum induced by these substrates.	Vitamin K 3	97-106	galactosidase beta 1	Homo sapiens	37-55
26345950-3	2015	Assessments of the expression of the beta-galactosidase enzyme were performed in the presence of menadione (MEN) and phenazine methosulfate (PMS) compounds at different final concentrations to evaluate the heterologous activation of the predicted promoter region of interest in C. violaceum induced by these substrates.	Methylphenazonium Methosulfate	117-139	galactosidase beta 1	Homo sapiens	37-55
26345950-3	2015	Assessments of the expression of the beta-galactosidase enzyme were performed in the presence of menadione (MEN) and phenazine methosulfate (PMS) compounds at different final concentrations to evaluate the heterologous activation of the predicted promoter region of interest in C. violaceum induced by these substrates.	Methylphenazonium Methosulfate	141-144	galactosidase beta 1	Homo sapiens	37-55
26345950-5	2015	On the other hand, significantly higher levels in the expression of the beta-galactosidase enzyme were detected exclusively in the presence of the PMS reagent at a final concentration of 50 mug/mL.	Methylphenazonium Methosulfate	147-150	galactosidase beta 1	Homo sapiens	72-90
25955790-5	2015	Further experiments confirmed that troxerutin inhibited the H2O2-induced production of ROS and upregulation of senescence-associated beta-galactosidase activity.	troxerutin	35-45	galactosidase beta 1	Homo sapiens	133-151
25923376-2	2015	Herein, to ascertain the effect of supramolecular backbone structure of cationic polyrotaxanes, the physicochemical properties and biological activity of polyelectrolyte complex with anionic beta-galactosidase (beta-gal) were investigated in comparison to a cationic linear polymer, poly[2-(N,N-dimethylaminoethyl) methacrylate] (PDMAEMA).	Rotaxanes	81-94	galactosidase beta 1	Homo sapiens	191-209
25923376-2	2015	Herein, to ascertain the effect of supramolecular backbone structure of cationic polyrotaxanes, the physicochemical properties and biological activity of polyelectrolyte complex with anionic beta-galactosidase (beta-gal) were investigated in comparison to a cationic linear polymer, poly[2-(N,N-dimethylaminoethyl) methacrylate] (PDMAEMA).	Rotaxanes	81-94	galactosidase beta 1	Homo sapiens	191-199
25923376-2	2015	Herein, to ascertain the effect of supramolecular backbone structure of cationic polyrotaxanes, the physicochemical properties and biological activity of polyelectrolyte complex with anionic beta-galactosidase (beta-gal) were investigated in comparison to a cationic linear polymer, poly[2-(N,N-dimethylaminoethyl) methacrylate] (PDMAEMA).	Polymers	274-281	galactosidase beta 1	Homo sapiens	191-209
25923376-2	2015	Herein, to ascertain the effect of supramolecular backbone structure of cationic polyrotaxanes, the physicochemical properties and biological activity of polyelectrolyte complex with anionic beta-galactosidase (beta-gal) were investigated in comparison to a cationic linear polymer, poly[2-(N,N-dimethylaminoethyl) methacrylate] (PDMAEMA).	Polymers	274-281	galactosidase beta 1	Homo sapiens	191-199
25923376-2	2015	Herein, to ascertain the effect of supramolecular backbone structure of cationic polyrotaxanes, the physicochemical properties and biological activity of polyelectrolyte complex with anionic beta-galactosidase (beta-gal) were investigated in comparison to a cationic linear polymer, poly[2-(N,N-dimethylaminoethyl) methacrylate] (PDMAEMA).	poly[2-(n,n-dimethylaminoethyl) methacrylate]	283-328	galactosidase beta 1	Homo sapiens	191-209
25923376-2	2015	Herein, to ascertain the effect of supramolecular backbone structure of cationic polyrotaxanes, the physicochemical properties and biological activity of polyelectrolyte complex with anionic beta-galactosidase (beta-gal) were investigated in comparison to a cationic linear polymer, poly[2-(N,N-dimethylaminoethyl) methacrylate] (PDMAEMA).	poly[2-(n,n-dimethylaminoethyl) methacrylate]	283-328	galactosidase beta 1	Homo sapiens	191-199
25923376-2	2015	Herein, to ascertain the effect of supramolecular backbone structure of cationic polyrotaxanes, the physicochemical properties and biological activity of polyelectrolyte complex with anionic beta-galactosidase (beta-gal) were investigated in comparison to a cationic linear polymer, poly[2-(N,N-dimethylaminoethyl) methacrylate] (PDMAEMA).	pdmaema	330-337	galactosidase beta 1	Homo sapiens	191-209
25923376-2	2015	Herein, to ascertain the effect of supramolecular backbone structure of cationic polyrotaxanes, the physicochemical properties and biological activity of polyelectrolyte complex with anionic beta-galactosidase (beta-gal) were investigated in comparison to a cationic linear polymer, poly[2-(N,N-dimethylaminoethyl) methacrylate] (PDMAEMA).	pdmaema	330-337	galactosidase beta 1	Homo sapiens	191-199
25964111-2	2015	Using this compound, we developed highly sensitive fluorescence-based high-throughput assays for both endo-beta-galactosidase and alpha-N-acetylgalactosaminidase activity specific for the oligosaccharide structure of the blood group A antigen.	Oligosaccharides	188-203	galactosidase beta 1	Homo sapiens	107-125
25955790-5	2015	Further experiments confirmed that troxerutin inhibited the H2O2-induced production of ROS and upregulation of senescence-associated beta-galactosidase activity.	Hydrogen Peroxide	60-64	galactosidase beta 1	Homo sapiens	133-151
26102064-3	2015	The guanidinium-cholesterol cationic lipid bis (guanidinium)-tren-cholesterol (BGTC) (bis (guanidinium)-tren-cholesterol) combined to the colipid dioleoyl phosphatidylethanolamine (DOPE) (dioleoyl phosphatidylethanolamine) was shown to efficiently deliver the beta-gal intracellularly without compromising its activity.	guanidinium-cholesterol	4-27	galactosidase beta 1	Homo sapiens	260-268
25722137-1	2015	Chitosan-grafted hydrogels were employed for immobilization and controlled released of beta-galactosidase.	Chitosan	0-8	galactosidase beta 1	Homo sapiens	87-105
25722137-2	2015	These hydrogels containing immobilized enzymes were employed to simulate the production of lactose-free food and controlled release of beta-galactosidase into lactose-intolerant individuals.	Lactose	159-166	galactosidase beta 1	Homo sapiens	135-153
26147980-6	2015	Final enzymatic product, 4-methylumbelliferone, obtained after adding exogenous beta-galactosidase, was quantified by LC/MRM-MS (liquid-chromatography/multiple-reaction-monitoring mass-spectrometry).	Hymecromone	25-46	galactosidase beta 1	Homo sapiens	80-98
26100615-3	2015	The light energy is provided by enzymatic activation of metastable 1,2-dioxetane substrates, whose protective groups are removed by hydrolytic enzymes such as beta-galactosidase and alkaline phosphatase.	1,2-dioxetane	67-80	galactosidase beta 1	Homo sapiens	159-177
26100615-6	2015	Using cells stained with fluorescent dialkylcarbocyanines as the energy recipients, we demonstrated CIEEL imaging of cellular beta-galactosidase or alkaline phosphatase activity.	dialkylcarbocyanines	37-57	galactosidase beta 1	Homo sapiens	126-144
26100615-6	2015	Using cells stained with fluorescent dialkylcarbocyanines as the energy recipients, we demonstrated CIEEL imaging of cellular beta-galactosidase or alkaline phosphatase activity.	cieel	100-105	galactosidase beta 1	Homo sapiens	126-144
26102064-3	2015	The guanidinium-cholesterol cationic lipid bis (guanidinium)-tren-cholesterol (BGTC) (bis (guanidinium)-tren-cholesterol) combined to the colipid dioleoyl phosphatidylethanolamine (DOPE) (dioleoyl phosphatidylethanolamine) was shown to efficiently deliver the beta-gal intracellularly without compromising its activity.	3-((N',N'-diguanidinoethylaminoethyl)carbamoyl)cholesterol	43-77	galactosidase beta 1	Homo sapiens	260-268
26102064-3	2015	The guanidinium-cholesterol cationic lipid bis (guanidinium)-tren-cholesterol (BGTC) (bis (guanidinium)-tren-cholesterol) combined to the colipid dioleoyl phosphatidylethanolamine (DOPE) (dioleoyl phosphatidylethanolamine) was shown to efficiently deliver the beta-gal intracellularly without compromising its activity.	3-((N',N'-diguanidinoethylaminoethyl)carbamoyl)cholesterol	79-83	galactosidase beta 1	Homo sapiens	260-268
26102064-3	2015	The guanidinium-cholesterol cationic lipid bis (guanidinium)-tren-cholesterol (BGTC) (bis (guanidinium)-tren-cholesterol) combined to the colipid dioleoyl phosphatidylethanolamine (DOPE) (dioleoyl phosphatidylethanolamine) was shown to efficiently deliver the beta-gal intracellularly without compromising its activity.	3-((N',N'-diguanidinoethylaminoethyl)carbamoyl)cholesterol	86-120	galactosidase beta 1	Homo sapiens	260-268
26102064-3	2015	The guanidinium-cholesterol cationic lipid bis (guanidinium)-tren-cholesterol (BGTC) (bis (guanidinium)-tren-cholesterol) combined to the colipid dioleoyl phosphatidylethanolamine (DOPE) (dioleoyl phosphatidylethanolamine) was shown to efficiently deliver the beta-gal intracellularly without compromising its activity.	colipid dioleoyl phosphatidylethanolamine	138-179	galactosidase beta 1	Homo sapiens	260-268
26047337-1	2015	beta-Galactosidase was immobilized on chitosan-coated magnetic Fe3O4 nanoparticles and was used to produce galactooligosaccharides (GOS) from lactose.	galactooligosaccharides	107-130	galactosidase beta 1	Homo sapiens	0-18
26047337-1	2015	beta-Galactosidase was immobilized on chitosan-coated magnetic Fe3O4 nanoparticles and was used to produce galactooligosaccharides (GOS) from lactose.	D-Glucitol-1,6-bisphosphate	132-135	galactosidase beta 1	Homo sapiens	0-18
26047337-0	2015	Production of Galactooligosaccharides Using beta-Galactosidase Immobilized on Chitosan-Coated Magnetic Nanoparticles with Tris(hydroxymethyl)phosphine as an Optional Coupling Agent.	galactooligosaccharides	14-37	galactosidase beta 1	Homo sapiens	44-62
26047337-0	2015	Production of Galactooligosaccharides Using beta-Galactosidase Immobilized on Chitosan-Coated Magnetic Nanoparticles with Tris(hydroxymethyl)phosphine as an Optional Coupling Agent.	Chitosan	78-86	galactosidase beta 1	Homo sapiens	44-62
26047337-1	2015	beta-Galactosidase was immobilized on chitosan-coated magnetic Fe3O4 nanoparticles and was used to produce galactooligosaccharides (GOS) from lactose.	Lactose	142-149	galactosidase beta 1	Homo sapiens	0-18
25839136-4	2015	However, amino iminosugar 8 showed selective inhibition against the beta-galactosidase (IC50 = 43 muM, Ki = 153 muM).	amino iminosugar	9-25	galactosidase beta 1	Homo sapiens	68-86
26047337-0	2015	Production of Galactooligosaccharides Using beta-Galactosidase Immobilized on Chitosan-Coated Magnetic Nanoparticles with Tris(hydroxymethyl)phosphine as an Optional Coupling Agent.	tris(hydroxymethyl)phosphine	122-150	galactosidase beta 1	Homo sapiens	44-62
26047337-1	2015	beta-Galactosidase was immobilized on chitosan-coated magnetic Fe3O4 nanoparticles and was used to produce galactooligosaccharides (GOS) from lactose.	ferryl iron	63-68	galactosidase beta 1	Homo sapiens	0-18
30647561-5	2015	A high elevation of NO level [achieved pharmacologically using the NO donor sodium nitroprusside (SNP), or genetically using the Glb1 suppressing line], activated the two ethylene biosynthetic genes 1-aminocyclopropane-1-carboxylate synthase (ACC synthase) and 1-aminocyclopropane-1-carboxylate oxidase (ACC oxidase).	ethylene	171-179	galactosidase beta 1	Homo sapiens	129-133
25952528-3	2015	Herein, we present an environmentally friendly strategy to construct a novel allosteric effect-based beta-galactosidase/Mg-Al layered double hydroxide (beta-gal/Mg-Al-LDH) nanobiocatalytic system via the delamination-reconstruction method.	double hydroxide	134-150	galactosidase beta 1	Homo sapiens	101-119
25876105-2	2015	Lysosomal-beta-galactosidase (GLB1) hydrolyzes beta-galactose from glycoconjugates and is the origin of senescence-associated beta-gal activity (SA-beta-gal).	beta-D-galactose	47-61	galactosidase beta 1	Homo sapiens	30-34
24931169-6	2015	When expressed in a tetracycline-inducible manner, the ectopically expressed activated form of Notch1 (ICN1) displayed oncogene-like characteristics inducing cellular senescence corroborated by the induction of G0/G1 cell-cycle arrest, Rb dephosphorylation, flat and enlarged cell morphology and senescence-associated beta-galactosidase activity.	Tetracycline	20-32	galactosidase beta 1	Homo sapiens	318-336
25758427-7	2015	Phosphorylation of Smad2 and Smad3 increased after 1 h of glycitin treatment, and phosphorylation continued for 24 h. Furthermore, the phosphorylated form of AKT was increased in glycitin-treated cells after 3 h and remained higher for 24 h. Thus, glycitin treatment produces anti-aging effects including increased total collagen in the culture media, decreased elastase, and decreased beta-galactosidase.	glycitin	179-187	galactosidase beta 1	Homo sapiens	386-404
25758427-7	2015	Phosphorylation of Smad2 and Smad3 increased after 1 h of glycitin treatment, and phosphorylation continued for 24 h. Furthermore, the phosphorylated form of AKT was increased in glycitin-treated cells after 3 h and remained higher for 24 h. Thus, glycitin treatment produces anti-aging effects including increased total collagen in the culture media, decreased elastase, and decreased beta-galactosidase.	glycitin	179-187	galactosidase beta 1	Homo sapiens	386-404
25876105-2	2015	Lysosomal-beta-galactosidase (GLB1) hydrolyzes beta-galactose from glycoconjugates and is the origin of senescence-associated beta-gal activity (SA-beta-gal).	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	145-156	galactosidase beta 1	Homo sapiens	30-34
25876105-11	2015	CONCLUSION: Increased GLB1 is a valuable marker in formalin-fixed paraffin-embedded (FFPE) tissues for the senescence-like phenotype and associates with improved cancer outcomes.	Formaldehyde	51-59	galactosidase beta 1	Homo sapiens	22-26
25437011-5	2015	Activation of the Wnt pathway by treatment with Wnt3a-conditioned medium or glycogen synthase kinase 3beta inhibitors, such as SB-216763 and 6-bromoindirubin-3"-oxime, delays the progression of cellular senescence as shown by the decrease in the senescence effectors p53 and pRb, lowered senescence-associated beta-galactosidase activity, and increased telomerase activity.	SB 216763	127-136	galactosidase beta 1	Homo sapiens	310-328
25876105-11	2015	CONCLUSION: Increased GLB1 is a valuable marker in formalin-fixed paraffin-embedded (FFPE) tissues for the senescence-like phenotype and associates with improved cancer outcomes.	Paraffin	66-74	galactosidase beta 1	Homo sapiens	22-26
25437011-5	2015	Activation of the Wnt pathway by treatment with Wnt3a-conditioned medium or glycogen synthase kinase 3beta inhibitors, such as SB-216763 and 6-bromoindirubin-3"-oxime, delays the progression of cellular senescence as shown by the decrease in the senescence effectors p53 and pRb, lowered senescence-associated beta-galactosidase activity, and increased telomerase activity.	6-bromoindirubin-3'-oxime	141-166	galactosidase beta 1	Homo sapiens	310-328
25600812-5	2015	GM1 gangliosidosis is caused by mutations in the GLB1 gene that encodes beta-galactosidase.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	49-53
24909670-7	2015	Cy-3-glu and Pg-3-glu treatments significantly (P &lt; 0.05) inhibited the increase in beta-galactosidase during the RPE cell ageing caused by visible light exposure.	cyanidin-3-o-glucoside	0-8	galactosidase beta 1	Homo sapiens	87-105
24909670-7	2015	Cy-3-glu and Pg-3-glu treatments significantly (P &lt; 0.05) inhibited the increase in beta-galactosidase during the RPE cell ageing caused by visible light exposure.	pelargonidin-3-glucoside	13-21	galactosidase beta 1	Homo sapiens	87-105
25647617-6	2015	beta-Galactosidase and beta-N-acetylhexosaminidase were used to convert complex oligosaccharides into two peaks containing either GlcNAc2Man3Fuc or GlcNAc2Man3, which simplified the chromatograms and data analysis.	Oligosaccharides	80-96	galactosidase beta 1	Homo sapiens	0-18
25647617-7	2015	More importantly, low abundance hybrid oligosaccharides can only be detected and qualified after beta-galactosidase and beta-N-acetylhexosaminidase digestion.	Oligosaccharides	39-55	galactosidase beta 1	Homo sapiens	97-115
25659627-0	2015	Transgalactosylation and hydrolytic activities of commercial preparations of beta-galactosidase for the synthesis of prebiotic carbohydrates.	Carbohydrates	127-140	galactosidase beta 1	Homo sapiens	77-95
25600812-5	2015	GM1 gangliosidosis is caused by mutations in the GLB1 gene that encodes beta-galactosidase.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	72-90
25733920-1	2015	AIM: Lactose and complex carbohydrates maldigestion, common food intolerances due to low gut content of alpha- and beta-galactosidase, lead to abdominal symptoms including pain, diarrhea, bloating, flatulence, and cramping.	Lactose	5-12	galactosidase beta 1	Homo sapiens	104-133
25733920-1	2015	AIM: Lactose and complex carbohydrates maldigestion, common food intolerances due to low gut content of alpha- and beta-galactosidase, lead to abdominal symptoms including pain, diarrhea, bloating, flatulence, and cramping.	Carbohydrates	25-38	galactosidase beta 1	Homo sapiens	104-133
25600812-6	2015	A lack of beta-galactosidase activity leads to the massive accumulation of GM1 ganglioside, which results in neurodegenerative pathology.	G(M1) Ganglioside	75-90	galactosidase beta 1	Homo sapiens	10-28
25451783-4	2015	To that purpose, we synthesized biotin-labeled peptides, corresponding to aggregation-determining sequences of the bacterial protein beta-galactosidase and two human disease biomarkers: C-reactive protein and prostate-specific antigen.	Biotin	32-38	galactosidase beta 1	Homo sapiens	133-151
25462622-3	2015	Screening of these polyhydroxylated azepanes toward a range of commercially available glycosidases was performed and one of the stereoisomers showed potent and selective inhibition toward beta-galactosidase (IC50=21 muM).	hexahydroazepine	36-44	galactosidase beta 1	Homo sapiens	188-206
24909380-1	2015	Recombinant alpha- and beta-galactosidases could be prepared in larger amounts for chemoenzymatic syntheses of glycosylated oligosaccharides relevant in nutrition approaches.	Oligosaccharides	124-140	galactosidase beta 1	Homo sapiens	12-42
25691190-1	2015	BACKGROUND: GM1 gangliosidosis is a disorder due to GLB1 gene mutation.	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	52-56
24993871-4	2015	(-)-Loliolide diminished senescence-associated beta-galactosidase activity (SA-beta-gal), the level of p21 protein, and the level of reactive oxygen species in senescent cells induced by adriamycin treatment.	loliolide	0-13	galactosidase beta 1	Homo sapiens	47-65
25557319-0	2015	Characterization of the cross-linked enzyme aggregates of a novel beta-galactosidase, a potential catalyst for the synthesis of galacto-oligosaccharides.	galacto-oligosaccharides	128-152	galactosidase beta 1	Homo sapiens	66-84
25557319-8	2015	To the best of our knowledge, this is the first report on the GOS synthesis using CLEAs of beta-galactosidase in an organic-aqueous biphasic system.	D-Glucitol-1,6-bisphosphate	62-65	galactosidase beta 1	Homo sapiens	91-109
25266506-5	2015	In that study, the binding of several proteins, including beta-galactosidase, to all possible dipeptides, tripeptides and tetrapeptides (using seven selected amino acids) was performed and analyzed in terms of the charge characteristics, hydrophobicity, etc., of the binding interaction.	Dipeptides	94-104	galactosidase beta 1	Homo sapiens	58-76
25266506-5	2015	In that study, the binding of several proteins, including beta-galactosidase, to all possible dipeptides, tripeptides and tetrapeptides (using seven selected amino acids) was performed and analyzed in terms of the charge characteristics, hydrophobicity, etc., of the binding interaction.	tripeptides	106-117	galactosidase beta 1	Homo sapiens	58-76
25450024-7	2015	Furthermore, the antiproliferative activity of the selected galactosides was successfully investigated in the presence of beta-galactosidase as a preliminary model of antibody directed enzyme prodrug therapy.	Galactosides	60-72	galactosidase beta 1	Homo sapiens	122-140
26235577-6	2015	Results showed that pretreatment with curcumin significantly attenuated the H2O2-induced HUVECs" premature senescence, which was evidenced by a decreased percentage of senescence-associated beta-galactosidase positive cells, improved cell division and decreased expression of senescence-associated protein p21 (all p&lt;0.05).	Curcumin	38-46	galactosidase beta 1	Homo sapiens	190-208
26235577-6	2015	Results showed that pretreatment with curcumin significantly attenuated the H2O2-induced HUVECs" premature senescence, which was evidenced by a decreased percentage of senescence-associated beta-galactosidase positive cells, improved cell division and decreased expression of senescence-associated protein p21 (all p&lt;0.05).	Hydrogen Peroxide	76-80	galactosidase beta 1	Homo sapiens	190-208
25483279-6	2015	The study indicated the contribution of an operon consisted of LacS symporter and beta-galactosidase to bifidobacterial GOS consumption.	D-Glucitol-1,6-bisphosphate	120-123	galactosidase beta 1	Homo sapiens	82-100
25444767-0	2014	(1)H NMR analysis of the lactose/beta-galactosidase-derived galacto-oligosaccharide components of Vivinal  GOS up to DP5.	Lactose	25-32	galactosidase beta 1	Homo sapiens	33-51
25670982-0	2014	Release of beta-galactosidase from poloxamine/alpha-cyclodextrin hydrogels.	poloxamine	35-45	galactosidase beta 1	Homo sapiens	11-29
25670982-0	2014	Release of beta-galactosidase from poloxamine/alpha-cyclodextrin hydrogels.	alpha-cyclodextrin	46-64	galactosidase beta 1	Homo sapiens	11-29
25670982-1	2014	All mammals lose their ability to produce lactase (beta-galactosidase), the enzyme that cleaves lactose into galactose and glucose, after weaning.	Lactose	96-103	galactosidase beta 1	Homo sapiens	51-69
25670982-1	2014	All mammals lose their ability to produce lactase (beta-galactosidase), the enzyme that cleaves lactose into galactose and glucose, after weaning.	Galactose	109-118	galactosidase beta 1	Homo sapiens	51-69
25670982-1	2014	All mammals lose their ability to produce lactase (beta-galactosidase), the enzyme that cleaves lactose into galactose and glucose, after weaning.	Glucose	123-130	galactosidase beta 1	Homo sapiens	51-69
25670982-6	2014	In this work, gels obtained by complexation of Tetronic 90R4 with alpha-cyclodextrin loaded with beta-galactosidase are proposed as a way to administer the enzyme immediately before or with the lactose-containing meal.	alpha-cyclodextrin	66-84	galactosidase beta 1	Homo sapiens	97-115
25670982-6	2014	In this work, gels obtained by complexation of Tetronic 90R4 with alpha-cyclodextrin loaded with beta-galactosidase are proposed as a way to administer the enzyme immediately before or with the lactose-containing meal.	Lactose	194-201	galactosidase beta 1	Homo sapiens	97-115
25444767-0	2014	(1)H NMR analysis of the lactose/beta-galactosidase-derived galacto-oligosaccharide components of Vivinal  GOS up to DP5.	galacto-oligosaccharide	60-83	galactosidase beta 1	Homo sapiens	33-51
25277226-6	2014	We observed that C-alkylation of the L-ido tetrahydroxylated azepane converts it from an alpha-L-fucosidase to a beta-glucosidase and beta-galactosidase inhibitor while N-alkylation of the D-gluco iminosugar significantly improves its inhibition profile leading to potent beta-glucosidase, beta-galactosidase, alpha-L-rhamnosidase and beta-glucuronidase inhibitors whatever the stereochemistry of the alkyl chain.	idose	37-42	galactosidase beta 1	Homo sapiens	134-152
24862567-5	2014	MTX variably inhibited the survival of melanoma cells and induced apoptosis as evident by annexin V positivity and senescence associated beta-galactosidase activity induction.	Methotrexate	0-3	galactosidase beta 1	Homo sapiens	137-155
25277226-6	2014	We observed that C-alkylation of the L-ido tetrahydroxylated azepane converts it from an alpha-L-fucosidase to a beta-glucosidase and beta-galactosidase inhibitor while N-alkylation of the D-gluco iminosugar significantly improves its inhibition profile leading to potent beta-glucosidase, beta-galactosidase, alpha-L-rhamnosidase and beta-glucuronidase inhibitors whatever the stereochemistry of the alkyl chain.	idose	37-42	galactosidase beta 1	Homo sapiens	290-308
25277226-6	2014	We observed that C-alkylation of the L-ido tetrahydroxylated azepane converts it from an alpha-L-fucosidase to a beta-glucosidase and beta-galactosidase inhibitor while N-alkylation of the D-gluco iminosugar significantly improves its inhibition profile leading to potent beta-glucosidase, beta-galactosidase, alpha-L-rhamnosidase and beta-glucuronidase inhibitors whatever the stereochemistry of the alkyl chain.	hexahydroazepine	61-68	galactosidase beta 1	Homo sapiens	134-152
25277226-6	2014	We observed that C-alkylation of the L-ido tetrahydroxylated azepane converts it from an alpha-L-fucosidase to a beta-glucosidase and beta-galactosidase inhibitor while N-alkylation of the D-gluco iminosugar significantly improves its inhibition profile leading to potent beta-glucosidase, beta-galactosidase, alpha-L-rhamnosidase and beta-glucuronidase inhibitors whatever the stereochemistry of the alkyl chain.	hexahydroazepine	61-68	galactosidase beta 1	Homo sapiens	290-308
25293992-10	2014	Functionally, the metabolism of carbohydrates, amino acids, and to a lesser extent, the metabolism of cofactors and vitamins were most dominant, and of which the enzymes beta-glucosidase (EC 3.2.1.21), beta-galactosidase (EC 3.2.1.23) and beta-N-acetylhexosaminidase (EC 3.2.1.52) were most dominant.	Carbohydrates	32-45	galactosidase beta 1	Homo sapiens	202-220
25260221-0	2014	Effect of copper oxide nanoparticles on the conformation and activity of beta-galactosidase.	cupric oxide	10-22	galactosidase beta 1	Homo sapiens	73-91
25260221-1	2014	The primary objective of this study is to explore the interaction of beta-galactosidase with copper oxide nanoparticles (CuO NPs).	cupric oxide	93-105	galactosidase beta 1	Homo sapiens	69-87
25260221-5	2014	The binding was studied by isothermal titration calorimetry (ITC) and the result revealed that the complexation is enthalpy driven, the DeltaH &lt;0, DeltaS &lt;0 indicates the formation of hydrogen bonds between beta-galactosidase and CuO NPs occurs.	Hydrogen	190-198	galactosidase beta 1	Homo sapiens	213-231
25152419-0	2014	Co-immobilized glucose oxidase and beta-galactosidase on bovine serum albumin coated allyl glycidyl ether (AGE)-ethylene glycol dimethacrylate (EGDM) copolymer as a biosensor for lactose determination in milk.	allyl glycidyl ether	85-105	galactosidase beta 1	Homo sapiens	35-53
25152419-0	2014	Co-immobilized glucose oxidase and beta-galactosidase on bovine serum albumin coated allyl glycidyl ether (AGE)-ethylene glycol dimethacrylate (EGDM) copolymer as a biosensor for lactose determination in milk.	ethylene dimethacrylate	112-142	galactosidase beta 1	Homo sapiens	35-53
25152419-0	2014	Co-immobilized glucose oxidase and beta-galactosidase on bovine serum albumin coated allyl glycidyl ether (AGE)-ethylene glycol dimethacrylate (EGDM) copolymer as a biosensor for lactose determination in milk.	ethylene dimethacrylate	144-148	galactosidase beta 1	Homo sapiens	35-53
25152419-0	2014	Co-immobilized glucose oxidase and beta-galactosidase on bovine serum albumin coated allyl glycidyl ether (AGE)-ethylene glycol dimethacrylate (EGDM) copolymer as a biosensor for lactose determination in milk.	copolymer	150-159	galactosidase beta 1	Homo sapiens	35-53
25152419-2	2014	The amino, thiol and carboxylic acid functional groups available on protein coated surface were utilized for covalent immobilization of glucose oxidase and beta-galactosidase, both independently, and in a step-wise manner on the same matrix, with no more than 10% loss of enzyme activity during immobilization.	amino,	4-10	galactosidase beta 1	Homo sapiens	156-174
25152419-2	2014	The amino, thiol and carboxylic acid functional groups available on protein coated surface were utilized for covalent immobilization of glucose oxidase and beta-galactosidase, both independently, and in a step-wise manner on the same matrix, with no more than 10% loss of enzyme activity during immobilization.	Sulfhydryl Compounds	11-16	galactosidase beta 1	Homo sapiens	156-174
25152419-2	2014	The amino, thiol and carboxylic acid functional groups available on protein coated surface were utilized for covalent immobilization of glucose oxidase and beta-galactosidase, both independently, and in a step-wise manner on the same matrix, with no more than 10% loss of enzyme activity during immobilization.	Carboxylic Acids	21-36	galactosidase beta 1	Homo sapiens	156-174
24971952-1	2014	Newly developed parallel small-scale enzymatic membrane reactors (EMRs) were used to enhance the synthesis of lactulose using beta-galactosidase.	Lactulose	110-119	galactosidase beta 1	Homo sapiens	126-144
24971952-3	2014	This was presumably caused by the action of beta-galactosidase which performed secondary hydrolysis upon the produced lactulose.	Lactulose	118-127	galactosidase beta 1	Homo sapiens	44-62
25004867-1	2014	Novel fluorogenic 2-deoxy-2-fluoroglycosyl acridinone active site titrating reagents were synthesised and kinetic parameters determined for their inactivation of two retaining beta-glucosidases, a beta-galactosidase, a beta-xylosidase and several cellulases.	2-deoxy-2-fluoroglycosyl acridinone	18-53	galactosidase beta 1	Homo sapiens	197-215
23727633-3	2014	METHODS: Features of senescence (beta-galactosidase activity at pH 6 (SA-beta-gal) and active mammalian/mechanistic target of rapamycin (mTOR) in cell cycle arrest) as well as the activity of the two main pathways leading to cell senescence were examined in glucocorticoid-treated primary human tenocytes.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	70-81	galactosidase beta 1	Homo sapiens	33-51
25263933-0	2014	Enteric-coated capsule containing beta-galactosidase-loaded polylactic acid nanocapsules: enzyme stability and milk lactose hydrolysis under simulated gastrointestinal conditions.	poly(lactide)	60-75	galactosidase beta 1	Homo sapiens	34-52
25263933-6	2014	Under the simulated intestinal condition, the enteric coating dissolved rapidly and released the beta-galactosidase-loaded PLA NCs, which exhibited greater stability against enzymatic degradation and higher hydrolysis ratio (~100%) towards milk lactose than the free beta-galactosidase.	Lactose	245-252	galactosidase beta 1	Homo sapiens	97-115
30011632-1	2014	The aim of this work was to investigate the possibility of producing microparticles containing beta-galactosidase, using different biopolymers (arabic gum, chitosan, modified chitosan, calcium alginate and sodium alginate) as encapsulating agents by a spray-drying process.	Alginates	185-201	galactosidase beta 1	Homo sapiens	95-113
30011632-1	2014	The aim of this work was to investigate the possibility of producing microparticles containing beta-galactosidase, using different biopolymers (arabic gum, chitosan, modified chitosan, calcium alginate and sodium alginate) as encapsulating agents by a spray-drying process.	Alginates	206-221	galactosidase beta 1	Homo sapiens	95-113
25216853-7	2014	The expression of the senescence associated beta galactosidase is observed by treatment with the natural androgen DHT or the less metabolized synthetic androgen R1881.	Dihydrotestosterone	114-117	galactosidase beta 1	Homo sapiens	44-62
24991705-0	2014	Amperometric detection of lactose using beta-galactosidase immobilized in layer-by-layer films.	Lactose	26-33	galactosidase beta 1	Homo sapiens	40-58
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Lactose	86-93	galactosidase beta 1	Homo sapiens	109-127
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Lactose	86-93	galactosidase beta 1	Homo sapiens	129-137
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Lactose	168-175	galactosidase beta 1	Homo sapiens	109-127
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Lactose	168-175	galactosidase beta 1	Homo sapiens	129-137
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Glucose	181-188	galactosidase beta 1	Homo sapiens	109-127
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Glucose	181-188	galactosidase beta 1	Homo sapiens	129-137
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Galactose	193-202	galactosidase beta 1	Homo sapiens	109-127
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Galactose	193-202	galactosidase beta 1	Homo sapiens	129-137
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Lactose	168-175	galactosidase beta 1	Homo sapiens	109-127
24991705-2	2014	In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme beta-galactosidase (beta-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people.	Lactose	168-175	galactosidase beta 1	Homo sapiens	129-137
24991705-3	2014	The biosensor was made with beta-Gal immobilized in layer-by-layer (LbL) films with the polyelectrolyte poly(ethylene imine) (PEI) and poly(vinyl sufonate) (PVS) on an indium tin oxide (ITO) electrode modified with a layer of Prussian Blue (PB).	poly	88-92	galactosidase beta 1	Homo sapiens	28-36
24991705-4	2014	With an ITO/PB/(PEI/PVS)1(PEI/beta-Gal)30 architecture, lactose could be determined with an amperometric method with sensitivity of 0.31 muA mmol(-1) cm(-2) and detection limit of 1.13 mmol L(-1), which is sufficient for detecting lactose in milk and for clinical exams.	Lactose	56-63	galactosidase beta 1	Homo sapiens	30-38
24991705-6	2014	Sum-frequency generation spectroscopy data for the interface between the LbL film and a buffer containing lactose indicated that beta-Gal lost order, which is the first demonstration of structural effects induced by the molecular recognition interaction with lactose.	Lactose	106-113	galactosidase beta 1	Homo sapiens	129-137
24991705-6	2014	Sum-frequency generation spectroscopy data for the interface between the LbL film and a buffer containing lactose indicated that beta-Gal lost order, which is the first demonstration of structural effects induced by the molecular recognition interaction with lactose.	Lactose	259-266	galactosidase beta 1	Homo sapiens	129-137
24713392-6	2014	Combining in vivo and in vitro studies, we show that M2 macrophages trigger hepatocyte senescence and enhance alcohol-induced hepatocyte senescence, as indicated by increased beta-galactosidase activity, elevated CDKN1A mRNA expression, and induction of nuclear p21.	Alcohols	110-117	galactosidase beta 1	Homo sapiens	175-193
24995152-5	2014	The galactoside glycoside 3b was assayed as substrate for in vitro beta-galactosidase enzymatic activity showing strong absorbance after releasing of the azoic chromophore.	galactoside glycoside	4-25	galactosidase beta 1	Homo sapiens	67-85
24970385-4	2014	Here, we report that exposure to DAC triggers senescence in chronic leukemia cell lines as evidenced by increased senescence-associated beta-galactosidase activity and lysosomal mass, accompanied by an up-regulation of cell cycle-related genes.	Decitabine	33-36	galactosidase beta 1	Homo sapiens	136-154
24737316-1	2014	GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal beta-galactosidase (beta-Gal), frequently related to misfolding and subsequent endoplasmic reticulum-associated degradation.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	112-130
24737316-1	2014	GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal beta-galactosidase (beta-Gal), frequently related to misfolding and subsequent endoplasmic reticulum-associated degradation.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	132-140
24737316-3	2014	In this report, we describe the enzymological properties of purified recombinant human beta-Gal(WT) and two representative mutations in GM1 gangliosidosis Japanese patients, beta-Gal(R201C) and beta-Gal(I51T).	G(M1) Ganglioside	136-139	galactosidase beta 1	Homo sapiens	174-182
24737316-6	2014	All compounds bind to the active site of beta-Gal with the sugar-mimicking moiety making hydrogen bonds to active site residues.	Sugars	59-64	galactosidase beta 1	Homo sapiens	41-49
24737316-6	2014	All compounds bind to the active site of beta-Gal with the sugar-mimicking moiety making hydrogen bonds to active site residues.	Hydrogen	89-97	galactosidase beta 1	Homo sapiens	41-49
24737316-8	2014	These results provide understanding on the mechanism of action of beta-Gal selective chaperoning by newly developed PC compounds.	pc	116-118	galactosidase beta 1	Homo sapiens	66-74
24737316-3	2014	In this report, we describe the enzymological properties of purified recombinant human beta-Gal(WT) and two representative mutations in GM1 gangliosidosis Japanese patients, beta-Gal(R201C) and beta-Gal(I51T).	G(M1) Ganglioside	136-139	galactosidase beta 1	Homo sapiens	174-182
24735108-0	2014	Synthesis of 1,5-dideoxy-1,5-iminoribitol C-glycosides through a nitrone-olefin cycloaddition domino strategy: identification of pharmacological chaperones of mutant human lysosomal beta-galactosidase.	1,5-dideoxy-1,5-iminoribitol c-glycosides	13-54	galactosidase beta 1	Homo sapiens	182-200
24735108-3	2014	The iminoribitol C-glycosides 7a-e and 8 were found to be modest beta-galactosidase (bGal) inhibitors.	iminoribitol c-glycosides	4-29	galactosidase beta 1	Homo sapiens	65-83
24735108-3	2014	The iminoribitol C-glycosides 7a-e and 8 were found to be modest beta-galactosidase (bGal) inhibitors.	iminoribitol c-glycosides	4-29	galactosidase beta 1	Homo sapiens	85-89
24646820-4	2014	For people lacking the LP trait, the fermentation of milk into yogurt and related products (a process known for &gt;=8500 y) aids milk digestion through the breakdown of some lactose and the provision of beta-galactosidase, which remains active in the gastrointestinal tract.	leucylproline	23-25	galactosidase beta 1	Homo sapiens	204-222
24762088-9	2014	A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase, p21, p27 and p53.	mir-125b	27-35	galactosidase beta 1	Homo sapiens	192-210
24608564-3	2014	The galactoside hydrolyzing enzymes of alpha- and beta-galactosidases have been shown to reduce the levels of galactosides in both the food matrix and the human gastrointestinal tract.	Galactosides	110-122	galactosidase beta 1	Homo sapiens	39-69
24629264-9	2014	These results indicated that Glyt110 is an unusual enzyme with beta-galactosidase activity but phylogenetically related to glycosyltransferase.	glyt110	29-36	galactosidase beta 1	Homo sapiens	63-81
24629264-3	2014	Sequence analysis revealed that glyt110 encoded a protein of 369 amino acids that, rather than belonging to a family typically known for beta-galactosidase activity, belonged to glycosyltransferase family 4.	glyt110	32-39	galactosidase beta 1	Homo sapiens	137-155
24672334-0	2014	Optimal immobilization of beta-galactosidase onto kappa-carrageenan gel beads using response surface methodology and its applications.	Carrageenan	50-67	galactosidase beta 1	Homo sapiens	26-44
24629264-5	2014	Biochemical characterization revealed that the beta-galactosidase activity of Glyt110 toward o-nitrophenyl-beta-D-galactopyranoside (ONPG) and lactose were identified to be 314+-18.3 and 32+-2.7 U/mg, correspondingly.	glyt110	78-85	galactosidase beta 1	Homo sapiens	47-65
24629264-5	2014	Biochemical characterization revealed that the beta-galactosidase activity of Glyt110 toward o-nitrophenyl-beta-D-galactopyranoside (ONPG) and lactose were identified to be 314+-18.3 and 32+-2.7 U/mg, correspondingly.	2-nitrophenylgalactoside	93-131	galactosidase beta 1	Homo sapiens	47-65
24629264-5	2014	Biochemical characterization revealed that the beta-galactosidase activity of Glyt110 toward o-nitrophenyl-beta-D-galactopyranoside (ONPG) and lactose were identified to be 314+-18.3 and 32+-2.7 U/mg, correspondingly.	Lactose	143-150	galactosidase beta 1	Homo sapiens	47-65
24503541-1	2014	Galectin-1 (Gal-1) belongs to a family of endogenous lectins with conserved carbohydrate recognition domains binding beta-galactosidase sugars and plays a vital role in regulating stem cell functions including determination of cell fate.	Carbohydrates	76-88	galactosidase beta 1	Homo sapiens	117-135
24503541-1	2014	Galectin-1 (Gal-1) belongs to a family of endogenous lectins with conserved carbohydrate recognition domains binding beta-galactosidase sugars and plays a vital role in regulating stem cell functions including determination of cell fate.	Sugars	136-142	galactosidase beta 1	Homo sapiens	117-135
24476133-7	2014	We observed that administration of MK-2206, an allosteric AKT inhibitor, increased levels of reactive oxygen species, up-regulated the microRNA miR-182 and several senescence-associated genes (including p16, p53, p21, and beta-galactosidase), and drove leiomyoma cells into stress-induced premature senescence (SIPS).	MK 2206	35-42	galactosidase beta 1	Homo sapiens	222-240
24672334-1	2014	beta-Galactosidase (beta-gal) was immobilized by covalent binding on novel kappa-carrageenan gel beads activated by two-step method; the gel beads were soaked in polyethyleneimine followed by glutaraldehyde.	Carrageenan	75-92	galactosidase beta 1	Homo sapiens	0-18
24672334-1	2014	beta-Galactosidase (beta-gal) was immobilized by covalent binding on novel kappa-carrageenan gel beads activated by two-step method; the gel beads were soaked in polyethyleneimine followed by glutaraldehyde.	Carrageenan	75-92	galactosidase beta 1	Homo sapiens	20-28
24672334-1	2014	beta-Galactosidase (beta-gal) was immobilized by covalent binding on novel kappa-carrageenan gel beads activated by two-step method; the gel beads were soaked in polyethyleneimine followed by glutaraldehyde.	aziridine	162-179	galactosidase beta 1	Homo sapiens	0-18
24672334-1	2014	beta-Galactosidase (beta-gal) was immobilized by covalent binding on novel kappa-carrageenan gel beads activated by two-step method; the gel beads were soaked in polyethyleneimine followed by glutaraldehyde.	aziridine	162-179	galactosidase beta 1	Homo sapiens	20-28
24672334-1	2014	beta-Galactosidase (beta-gal) was immobilized by covalent binding on novel kappa-carrageenan gel beads activated by two-step method; the gel beads were soaked in polyethyleneimine followed by glutaraldehyde.	Glutaral	192-206	galactosidase beta 1	Homo sapiens	0-18
24672334-1	2014	beta-Galactosidase (beta-gal) was immobilized by covalent binding on novel kappa-carrageenan gel beads activated by two-step method; the gel beads were soaked in polyethyleneimine followed by glutaraldehyde.	Glutaral	192-206	galactosidase beta 1	Homo sapiens	20-28
24672334-7	2014	The full conversion experiment showed that the immobilized enzyme form is active as that of the free enzyme as both of them reached their maximum 100% relative hydrolysis at 4 h. The reusability test proved the durability of the kappa-carrageenan beads loaded with beta -galactosidase for 20 cycles with retention of 60% of the immobilized enzyme activity to be more convenient for industrial uses.	Carrageenan	229-246	galactosidase beta 1	Homo sapiens	265-284
23968720-2	2013	While analyzing human sperm motility, we found that sperm treated with endo-beta-galactosidase (EBG), which specifically hydrolyzes poly-N-acetyllactosamine type glycans (polyLacs), enhanced motility.	poly-N-acetyllactosamine	132-156	galactosidase beta 1	Homo sapiens	76-94
24411444-1	2014	The study demonstrates the properties of conjugation of beta-galactosidase with a thermo-responsive polymer, poly-N-isopropylacrylamide (PNIPAAm) in comparison to a non-responsive polymer, poly-acrylamide (PAAm).	Polymers	100-107	galactosidase beta 1	Homo sapiens	56-74
24411444-1	2014	The study demonstrates the properties of conjugation of beta-galactosidase with a thermo-responsive polymer, poly-N-isopropylacrylamide (PNIPAAm) in comparison to a non-responsive polymer, poly-acrylamide (PAAm).	poly-N-isopropylacrylamide	109-135	galactosidase beta 1	Homo sapiens	56-74
24411444-1	2014	The study demonstrates the properties of conjugation of beta-galactosidase with a thermo-responsive polymer, poly-N-isopropylacrylamide (PNIPAAm) in comparison to a non-responsive polymer, poly-acrylamide (PAAm).	poly-N-isopropylacrylamide	137-144	galactosidase beta 1	Homo sapiens	56-74
24411444-1	2014	The study demonstrates the properties of conjugation of beta-galactosidase with a thermo-responsive polymer, poly-N-isopropylacrylamide (PNIPAAm) in comparison to a non-responsive polymer, poly-acrylamide (PAAm).	polyacrylamide	140-144	galactosidase beta 1	Homo sapiens	56-74
24411444-5	2014	The addition of ethylene glycol (20%, v/v) enhances the activity (by 45%) of PNIPAAm-beta-galactosidase with no loss in stability; however; the trend is reversed with the addition of ethanol.	Ethylene Glycol	16-31	galactosidase beta 1	Homo sapiens	85-103
24411444-5	2014	The addition of ethylene glycol (20%, v/v) enhances the activity (by 45%) of PNIPAAm-beta-galactosidase with no loss in stability; however; the trend is reversed with the addition of ethanol.	Ethanol	183-190	galactosidase beta 1	Homo sapiens	85-103
24411444-9	2014	Finally, PNIPAAm-beta-galactosidase was tested to synthesize galacto-oligosaccharides from lactose solution.	galacto-oligosaccharides	61-85	galactosidase beta 1	Homo sapiens	17-35
24411444-9	2014	Finally, PNIPAAm-beta-galactosidase was tested to synthesize galacto-oligosaccharides from lactose solution.	Lactose	91-98	galactosidase beta 1	Homo sapiens	17-35
24411611-6	2014	In irradiated H460 xenografts, concurrent therapy with BEZ235 and AG014699 resulted in sustained Gamma-H2AX (gammaH2AX) staining and prominent beta-galactosidase activity.	dactolisib	55-61	galactosidase beta 1	Homo sapiens	143-161
24411611-6	2014	In irradiated H460 xenografts, concurrent therapy with BEZ235 and AG014699 resulted in sustained Gamma-H2AX (gammaH2AX) staining and prominent beta-galactosidase activity.	rucaparib	66-74	galactosidase beta 1	Homo sapiens	143-161
25109641-1	2014	We immobilized an antibody (anti-beta-Galactosidase) on a polystyrene microsphere by using a covalent bond, and observed the resonance peaks in the scattered light intensity spectra related to the whispering gallery mode (WGM) excitation of the microsphere.	Polystyrenes	58-69	galactosidase beta 1	Homo sapiens	33-51
25115457-7	2014	Treatment with hecogenin acetate induced G0/G1-phase arrest at two concentrations (75 and 100 microM, 74% and 84.3% respectively), and increased the staining of senescence-associated beta -galactosidase positive cells.	hecogenin acetate	15-32	galactosidase beta 1	Homo sapiens	183-202
24967391-1	2014	OBJECTIVE: To establish whether supplementation with a standard oral dose of Beta-Galactosidase affects hydrogen breath excretion in patients presenting with lactose malabsorption.	Hydrogen	104-112	galactosidase beta 1	Homo sapiens	77-95
24478550-4	2014	A principle of the determination of beta-galactosidase activity was fluorometric measurement of a deprotonated form of 4-methylumbelliferone released in the enzymatic reaction.	Hymecromone	119-140	galactosidase beta 1	Homo sapiens	36-54
24478550-6	2014	We observed the temperature-dependent substrate inhibition effect and determined the substrate (4-MU-beta-d-galactopyranoside) concentration which should be used to determine acid beta-galactosidase activity at 37  C (0.8 mM) and at room temperature (0.6 mM).	4-mu-beta-d-galactopyranoside	96-125	galactosidase beta 1	Homo sapiens	180-198
24790757-7	2014	Alanine was found to be significant and high in the helix region of psychrophiles and valine counters in thermophilic beta -galactosidase.	Alanine	0-7	galactosidase beta 1	Homo sapiens	118-137
24790757-7	2014	Alanine was found to be significant and high in the helix region of psychrophiles and valine counters in thermophilic beta -galactosidase.	Valine	86-92	galactosidase beta 1	Homo sapiens	118-137
24156787-3	2013	Notably, the derived heterofusion proteins are able to cross cellular membranes, dissociate at acidic pH due to the iminobiotin linker and preserve the enzymatic activity of the cargo proteins beta-galactosidase and the enzymatic subunit of Clostridium botulinum C2 toxin.	iminobiotin	116-127	galactosidase beta 1	Homo sapiens	193-211
23933099-3	2013	Our results demonstrated that exposure of human metastatic melanoma cells (WM9) to simvastatin induces a senescent phenotype, characterized by G1 arrest, positive staining for senescence-associated beta-galactosidase assay, and morphological changes.	Simvastatin	83-94	galactosidase beta 1	Homo sapiens	198-216
24003438-3	2013	Careful choice of reagents allowed the preparation of high resolution cellular activity maps highlighting the specific conversion of the commonly used ELISA reagent 5-bromo-4-chloro-3-indolyl beta-D-galactopyranoside (X-Gal), by wild type beta-galactosidase enzymes.	5-bromo-4-chloro-3-indolyl beta-galactoside	165-216	galactosidase beta 1	Homo sapiens	239-257
24003438-3	2013	Careful choice of reagents allowed the preparation of high resolution cellular activity maps highlighting the specific conversion of the commonly used ELISA reagent 5-bromo-4-chloro-3-indolyl beta-D-galactopyranoside (X-Gal), by wild type beta-galactosidase enzymes.	5-bromo-4-chloro-3-indolyl beta-galactoside	218-223	galactosidase beta 1	Homo sapiens	239-257
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	Acrylamide	91-101	galactosidase beta 1	Homo sapiens	13-31
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	N,N'-methylenebisacrylamide	125-152	galactosidase beta 1	Homo sapiens	13-31
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	Bismuth	154-157	galactosidase beta 1	Homo sapiens	13-31
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	poly(ethylene glycol)diacrylate	178-210	galactosidase beta 1	Homo sapiens	13-31
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	poly(ethylene glycol)diacrylate	212-217	galactosidase beta 1	Homo sapiens	13-31
24105816-0	2013	Development of luminescent coelenterazine derivatives activatable by beta-galactosidase for monitoring dual gene expression.	coelenterazine	27-41	galactosidase beta 1	Homo sapiens	69-87
24105816-1	2013	Two bioluminogenic caged coelenterazine derivatives (bGalCoel and bGalNoCoel) were designed and synthesized to detect beta-galactosidase activity and expression by means of bioluminescence imaging.	coelenterazine	25-39	galactosidase beta 1	Homo sapiens	118-136
24105816-3	2013	Both probes contain beta-galactosidase cleavable caging groups at the carbonyl group of the imidazo-pyrazinone moiety.	imidazo-pyrazinone	92-110	galactosidase beta 1	Homo sapiens	20-38
24105816-6	2013	It was determined that coelenterazine readily diffuses in and out of cells after uncaging by beta-galactosidase.	coelenterazine	23-37	galactosidase beta 1	Homo sapiens	93-111
24293256-4	2014	beta-Galactosidase and glucose oxidase were selected as a model for enzyme assays to demonstrate the applicability of Co3O4-SiO2 mesoporous nanocomposite material in multienzyme immobilization.	co3o4	118-123	galactosidase beta 1	Homo sapiens	0-18
24267340-3	2014	EXPERIMENTS: Two enzymes, beta-galactosidase (beta-Gal) and alkaline phosphatase (AP) were immobilized onto SIFs using the interactions of avidin-modified enzymes with (i) a monolayer of biotinylated bovine serum albumin (b-BSA) and/or (ii) a monolayer of biotinylated poly(ethylene-glycol)-amine (BEA molecular weight: 550-10,000Da).	poly(ethylene-glycol)-amine	269-296	galactosidase beta 1	Homo sapiens	26-44
24156692-0	2013	Metagenomic approach for the isolation of a thermostable beta-galactosidase with high tolerance of galactose and glucose from soil samples of Turpan Basin.	Galactose	99-108	galactosidase beta 1	Homo sapiens	57-75
24156692-0	2013	Metagenomic approach for the isolation of a thermostable beta-galactosidase with high tolerance of galactose and glucose from soil samples of Turpan Basin.	Glucose	113-120	galactosidase beta 1	Homo sapiens	57-75
24156692-5	2013	RESULTS: In the present study, a novel beta-galactosidase (Gal308) consisting of 658 amino acids was identified from a metagenomic library from soil samples of Turpan Basin in China by functional screening.	gal308	59-65	galactosidase beta 1	Homo sapiens	39-57
23968720-2	2013	While analyzing human sperm motility, we found that sperm treated with endo-beta-galactosidase (EBG), which specifically hydrolyzes poly-N-acetyllactosamine type glycans (polyLacs), enhanced motility.	Polysaccharides	162-169	galactosidase beta 1	Homo sapiens	76-94
23968720-2	2013	While analyzing human sperm motility, we found that sperm treated with endo-beta-galactosidase (EBG), which specifically hydrolyzes poly-N-acetyllactosamine type glycans (polyLacs), enhanced motility.	polylacs	171-179	galactosidase beta 1	Homo sapiens	76-94
23931694-4	2013	Besides glucose bioassay, the amplification of calibration parameters was also studied in cascaded two-enzyme lactose biosensor, where the initial step of lactose bio-recognition, the beta-galactosidase - catalyzed lactose hydrolysis, was additionally accelerated by magnesium ions.	Lactose	110-117	galactosidase beta 1	Homo sapiens	184-202
23931694-4	2013	Besides glucose bioassay, the amplification of calibration parameters was also studied in cascaded two-enzyme lactose biosensor, where the initial step of lactose bio-recognition, the beta-galactosidase - catalyzed lactose hydrolysis, was additionally accelerated by magnesium ions.	Lactose	155-162	galactosidase beta 1	Homo sapiens	184-202
23931694-4	2013	Besides glucose bioassay, the amplification of calibration parameters was also studied in cascaded two-enzyme lactose biosensor, where the initial step of lactose bio-recognition, the beta-galactosidase - catalyzed lactose hydrolysis, was additionally accelerated by magnesium ions.	Lactose	155-162	galactosidase beta 1	Homo sapiens	184-202
23931694-4	2013	Besides glucose bioassay, the amplification of calibration parameters was also studied in cascaded two-enzyme lactose biosensor, where the initial step of lactose bio-recognition, the beta-galactosidase - catalyzed lactose hydrolysis, was additionally accelerated by magnesium ions.	Magnesium	267-276	galactosidase beta 1	Homo sapiens	184-202
23871936-3	2013	The results showed that conditioned medium (CM) derived from senescent HPMCs elicited a senescence response (growth inhibition coupled with increased expression of senescence-associated beta-galactosidase and accumulation of histone gamma-H2A.X) in either early-passage HPMCs or HPFBs.	hpmcs	71-76	galactosidase beta 1	Homo sapiens	186-204
23984931-3	2013	In our study, tert-butyl hydroperoxide (tBHP)-induced cells accelerated HMC senescence, as judged by increased senescence-associated beta-galactosidase stained positive cells, morphological changes, and G0-G1 cell cycle arrest.	tert-Butylhydroperoxide	14-38	galactosidase beta 1	Homo sapiens	133-151
23984931-3	2013	In our study, tert-butyl hydroperoxide (tBHP)-induced cells accelerated HMC senescence, as judged by increased senescence-associated beta-galactosidase stained positive cells, morphological changes, and G0-G1 cell cycle arrest.	tert-Butylhydroperoxide	40-44	galactosidase beta 1	Homo sapiens	133-151
24067199-7	2013	Elevated levels of senescence-associated beta-galactosidase was observed in HepG2 cells exposed to low doses of cisplatin.	Cisplatin	112-121	galactosidase beta 1	Homo sapiens	41-59
24018455-0	2013	The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data.	Alcohols	84-91	galactosidase beta 1	Homo sapiens	22-40
23831247-1	2013	BACKGROUND: GM1 gangliosidosis is a rare disease due to mutations in the GLB1 gene and autosomal recessive deficiency of beta-galactosidase.	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	73-77
24018455-0	2013	The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data.	Nicotine	96-104	galactosidase beta 1	Homo sapiens	22-40
24018455-3	2013	This is the first study to evaluate the activity of the serum senescence marker GAL in colon cancer patients with a history of alcohol and nicotine dependence, as a potential factor of worse cancer prognosis.	Alcohols	127-134	galactosidase beta 1	Homo sapiens	80-83
24018455-3	2013	This is the first study to evaluate the activity of the serum senescence marker GAL in colon cancer patients with a history of alcohol and nicotine dependence, as a potential factor of worse cancer prognosis.	Nicotine	139-147	galactosidase beta 1	Homo sapiens	80-83
24018455-9	2013	RESULTS: The activity of serum GAL was significantly higher in colon cancer patients with a history of alcohol and nicotine dependence, in comparison to colon cancer patients without a history of drinking/smoking (p=0.015; 46% increase), and the controls (p=0.0002; 81% increase).	Alcohols	103-110	galactosidase beta 1	Homo sapiens	31-34
24018455-9	2013	RESULTS: The activity of serum GAL was significantly higher in colon cancer patients with a history of alcohol and nicotine dependence, in comparison to colon cancer patients without a history of drinking/smoking (p=0.015; 46% increase), and the controls (p=0.0002; 81% increase).	Nicotine	115-123	galactosidase beta 1	Homo sapiens	31-34
24018455-10	2013	The activity of serum GAL in colon cancer patients without a history of alcohol/nicotine dependence was higher than the activity in the controls (p = 0.043; 24% increase).	Alcohols	72-79	galactosidase beta 1	Homo sapiens	22-25
24018455-10	2013	The activity of serum GAL in colon cancer patients without a history of alcohol/nicotine dependence was higher than the activity in the controls (p = 0.043; 24% increase).	Nicotine	80-88	galactosidase beta 1	Homo sapiens	22-25
24018455-11	2013	DISCUSSION/CONCLUSION: Higher activity of beta-galactosidase may potentially reflect the accelerated growth of the cancer, invasion, metastases, and maturation, when alcohol and nicotine dependence coincide with colon cancer.	Alcohols	166-173	galactosidase beta 1	Homo sapiens	42-60
24018455-11	2013	DISCUSSION/CONCLUSION: Higher activity of beta-galactosidase may potentially reflect the accelerated growth of the cancer, invasion, metastases, and maturation, when alcohol and nicotine dependence coincide with colon cancer.	Nicotine	178-186	galactosidase beta 1	Homo sapiens	42-60
23607751-9	2013	After doxorubicin, beta-Gal staining increased significantly in SSc-MSCs.	Doxorubicin	6-17	galactosidase beta 1	Homo sapiens	19-27
23690541-2	2013	Etoposide- or doxorubicin-treated cells exhibited senescent morphology, growth arrest, and positive staining for senescence-associated beta-galactosidase.	Etoposide	0-9	galactosidase beta 1	Homo sapiens	135-153
23690541-2	2013	Etoposide- or doxorubicin-treated cells exhibited senescent morphology, growth arrest, and positive staining for senescence-associated beta-galactosidase.	Doxorubicin	14-25	galactosidase beta 1	Homo sapiens	135-153
23463175-6	2013	Yeast two-hybrid, beta-galactosidase filter, and bimolecular fluorescence complementation (BiFC) assays confirmed that ten of the 12 alanine-substituted mutations blocked the interaction with NbPCIP1.	Alanine	133-140	galactosidase beta 1	Homo sapiens	18-36
23775268-5	2013	As a promising alternative to the chemical method, enzymatic conversion of lactose into lactulose by beta-galactosidase or cellobiose 2-epimerase has recently gained a great deal of attention.	Lactose	75-82	galactosidase beta 1	Homo sapiens	101-119
23775268-5	2013	As a promising alternative to the chemical method, enzymatic conversion of lactose into lactulose by beta-galactosidase or cellobiose 2-epimerase has recently gained a great deal of attention.	Lactulose	88-97	galactosidase beta 1	Homo sapiens	101-119
23775268-9	2013	Furthermore, future research needs of beta-galactosidase and cellobiose 2-epimerase for the enzymatic synthesis of lactulose and 1-lactulose are reviewed.	Lactulose	115-124	galactosidase beta 1	Homo sapiens	38-56
23775268-9	2013	Furthermore, future research needs of beta-galactosidase and cellobiose 2-epimerase for the enzymatic synthesis of lactulose and 1-lactulose are reviewed.	1-Lactulose	129-140	galactosidase beta 1	Homo sapiens	38-56
23744352-8	2013	Consequently, cells responded to NS1643 by developing a senescence-like phenotype associated with increased protein levels of the tumor suppressors p21 and p16(INK4a) and by a positive beta-galactosidase assay.	1,3-bis(2-hydroxy-5-trifluoromethylphenyl)urea	33-39	galactosidase beta 1	Homo sapiens	185-203
23722550-7	2013	In tumor xenografts, we showed that administering rapamycin delayed tumor regrowth after irradiation and increased senescence-associated beta-galactosidase staining in the tumor.	Sirolimus	50-59	galactosidase beta 1	Homo sapiens	137-155
23602729-7	2013	Thus, C3-GD successfully detects beta-galactosidase activity in vivo and shows promise as a lacZ gene (1)H MR reporter molecule.	c3-gd	6-11	galactosidase beta 1	Homo sapiens	33-51
23661043-9	2013	In addition, idebenone pretreatment significantly attenuated the increase of histone-associated DNA fragmentation, induction of senescence-associated beta-galactosidase, and intracellular reactive oxygen species after treatment with H2O2.	idebenone	13-22	galactosidase beta 1	Homo sapiens	150-168
23661043-9	2013	In addition, idebenone pretreatment significantly attenuated the increase of histone-associated DNA fragmentation, induction of senescence-associated beta-galactosidase, and intracellular reactive oxygen species after treatment with H2O2.	Hydrogen Peroxide	233-237	galactosidase beta 1	Homo sapiens	150-168
23730211-8	2013	Therefore, using different markers of senescence [senescence-associated beta-galactosidase (SA-beta-gal) activity, Ki-67 and Lamin B1 levels, and bromodeoxyuridine incorporation], we have shown that curcumin markedly suppresses Lamin B1 and triggers DNA damage-independent senescence in proliferating but not quiescent breast stromal fibroblasts.	Curcumin	199-207	galactosidase beta 1	Homo sapiens	72-90
23305208-8	2013	No interference from substrates/products made SDESA of beta-galactosidase and ALP simple for ELISA of penicillin G and clenbuterol in one well, and the quantification limit of either hapten was comparable to that via a separate assay.	sdesa	46-51	galactosidase beta 1	Homo sapiens	55-73
23486479-3	2013	beta-Galactosidase promotes the isomerization by means of an acceptor site that binds glucose after its cleavage from lactose and thus delays its exit from the site.	Glucose	86-93	galactosidase beta 1	Homo sapiens	0-18
23486479-3	2013	beta-Galactosidase promotes the isomerization by means of an acceptor site that binds glucose after its cleavage from lactose and thus delays its exit from the site.	Lactose	118-125	galactosidase beta 1	Homo sapiens	0-18
23486479-5	2013	We present structural data mapping the glucose site based on a substituted enzyme (G794A-beta-galactosidase) that traps allolactose.	Glucose	39-46	galactosidase beta 1	Homo sapiens	89-107
23486479-15	2013	This shows that the glucose binding site of beta-galactosidase played an important role in lac operon evolution.	Glucose	20-27	galactosidase beta 1	Homo sapiens	44-62
23183935-5	2013	All of the enzyme activities were strongly affected by metal contamination and showed the following inhibition sequence: phosphatase (30-64 %) &lt; arylsulfatase (38-97 %) &lt;= urease (1-100 %) &lt;= beta-galactosidase (30-100 %) &lt; dehydrogenase (69-100 %).	Metals	55-60	galactosidase beta 1	Homo sapiens	201-219
23756401-9	2013	Exposure of both cell types to lower concentrations of MTX resulted in premature senescence (SIPS), which was accompanied with typical morphological changes, increased activity of senescence-associated beta-galactosidase, persisting DSBs-associated gammaH2AX foci and cell cycle arrest in G2 phase.	Mitoxantrone	55-58	galactosidase beta 1	Homo sapiens	202-220
23391334-0	2013	Novel molecular platform integrated iron chelation therapy for 1H-MRI detection of beta-galactosidase activity.	Iron	36-40	galactosidase beta 1	Homo sapiens	83-101
23391334-0	2013	Novel molecular platform integrated iron chelation therapy for 1H-MRI detection of beta-galactosidase activity.	Hydrogen	63-65	galactosidase beta 1	Homo sapiens	83-101
23391334-1	2013	Targeting the increased Fe(3+) content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for (1)H-magnetic resonance imaging (MRI) detection of beta-galactosidase (beta-gal) activity.	ferric sulfate	24-30	galactosidase beta 1	Homo sapiens	184-202
23391334-1	2013	Targeting the increased Fe(3+) content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for (1)H-magnetic resonance imaging (MRI) detection of beta-galactosidase (beta-gal) activity.	ferric sulfate	24-30	galactosidase beta 1	Homo sapiens	184-192
23391334-1	2013	Targeting the increased Fe(3+) content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for (1)H-magnetic resonance imaging (MRI) detection of beta-galactosidase (beta-gal) activity.	Iron	106-110	galactosidase beta 1	Homo sapiens	184-202
23391334-1	2013	Targeting the increased Fe(3+) content in tumors, we propose a novel molecular platform integrated cancer iron chelation therapy for (1)H-magnetic resonance imaging (MRI) detection of beta-galactosidase (beta-gal) activity.	Iron	106-110	galactosidase beta 1	Homo sapiens	184-192
23391334-2	2013	Following this idea, we have designed, synthesized, and characterized a series of beta-d-galactosides conjugated with various chelators and demonstrated the feasibility of this concept for assessing beta-gal activity in solution by (1)H-MRI T1 and T2 relaxation mapping.	beta-D-galactose	82-101	galactosidase beta 1	Homo sapiens	199-207
23364789-7	2013	Cells treated with SN-38 displayed morphological characteristics of senescence and express senescence-associated beta-galactosidase activity.	Irinotecan	19-24	galactosidase beta 1	Homo sapiens	113-131
23478908-4	2013	Using this device we determine Km and kcat for beta-galactosidase and the fluorogenic substrate Resorufin beta-D-galactopyranoside (RBG) to be 442 muM and 1070 s(-1), respectively.	resorufin galactopyranoside	132-135	galactosidase beta 1	Homo sapiens	47-65
23478908-5	2013	Furthermore, we examine the inhibitory effects of isopropyl-beta-D-thiogalactopyranoside (IPTG) on beta-galactosidase.	Isopropyl Thiogalactoside	50-88	galactosidase beta 1	Homo sapiens	99-117
23478908-5	2013	Furthermore, we examine the inhibitory effects of isopropyl-beta-D-thiogalactopyranoside (IPTG) on beta-galactosidase.	Isopropyl Thiogalactoside	90-94	galactosidase beta 1	Homo sapiens	99-117
23519143-0	2013	Enzyme-mediated nutrient release: glucose-precursor activation by beta-galactosidase to induce bacterial growth.	Glucose	34-41	galactosidase beta 1	Homo sapiens	66-84
23519143-3	2013	A masked glucose precursor that is activated by beta-galactosidase was used as a carbon source for bacterial growth in a glucose-deficient medium.	Glucose	9-16	galactosidase beta 1	Homo sapiens	48-66
23519143-3	2013	A masked glucose precursor that is activated by beta-galactosidase was used as a carbon source for bacterial growth in a glucose-deficient medium.	Carbon	81-87	galactosidase beta 1	Homo sapiens	48-66
23353997-0	2013	Optimization of lactulose synthesis from whey lactose by immobilized beta-galactosidase and glucose isomerase.	Lactulose	16-25	galactosidase beta 1	Homo sapiens	69-87
23353997-0	2013	Optimization of lactulose synthesis from whey lactose by immobilized beta-galactosidase and glucose isomerase.	Lactose	46-53	galactosidase beta 1	Homo sapiens	69-87
23353997-1	2013	In the present study, commercially available whey was used as a lactose source, and immobilized beta-galactosidase and glucose isomerase were used to synthesize lactulose from whey lactose in the absence of fructose.	Lactulose	161-170	galactosidase beta 1	Homo sapiens	96-114
23353997-1	2013	In the present study, commercially available whey was used as a lactose source, and immobilized beta-galactosidase and glucose isomerase were used to synthesize lactulose from whey lactose in the absence of fructose.	Lactose	181-188	galactosidase beta 1	Homo sapiens	96-114
23353997-1	2013	In the present study, commercially available whey was used as a lactose source, and immobilized beta-galactosidase and glucose isomerase were used to synthesize lactulose from whey lactose in the absence of fructose.	Fructose	207-215	galactosidase beta 1	Homo sapiens	96-114
23353997-4	2013	When the lactulose synthesis was carried out at 53.5 C using 20% (w/v) whey lactose, 12U/ml of immobilized beta-galactosidase and 60U/ml of immobilized glucose isomerase in 100mM sodium phosphate buffer at pH 7.5, the lactulose concentration and specific productivity were 7.68g/l and 0.32mg/Uh, respectively.	Lactulose	9-18	galactosidase beta 1	Homo sapiens	107-125
23305208-8	2013	No interference from substrates/products made SDESA of beta-galactosidase and ALP simple for ELISA of penicillin G and clenbuterol in one well, and the quantification limit of either hapten was comparable to that via a separate assay.	Penicillin G	102-114	galactosidase beta 1	Homo sapiens	55-73
23305208-8	2013	No interference from substrates/products made SDESA of beta-galactosidase and ALP simple for ELISA of penicillin G and clenbuterol in one well, and the quantification limit of either hapten was comparable to that via a separate assay.	Clenbuterol	119-130	galactosidase beta 1	Homo sapiens	55-73
23274723-0	2013	Effects of alcohols and compatible solutes on the activity of beta-galactosidase.	Alcohols	11-19	galactosidase beta 1	Homo sapiens	62-80
23274723-2	2013	The effects of alcohols on the steady-state kinetic parameters of the model enzyme beta-galactosidase were studied.	Alcohols	15-23	galactosidase beta 1	Homo sapiens	83-101
23274723-7	2013	In the case of the ethanol- or propanol-inhibited beta-galactosidase, the addition of compatible solutes was unable to restore the enzyme"s kinetic parameters to their uninhibited levels; addition of chaotropic solutes such as urea tended to enhance the effects of these alcohols.	Ethanol	19-26	galactosidase beta 1	Homo sapiens	50-68
23274723-7	2013	In the case of the ethanol- or propanol-inhibited beta-galactosidase, the addition of compatible solutes was unable to restore the enzyme"s kinetic parameters to their uninhibited levels; addition of chaotropic solutes such as urea tended to enhance the effects of these alcohols.	1-Propanol	31-39	galactosidase beta 1	Homo sapiens	50-68
23274723-7	2013	In the case of the ethanol- or propanol-inhibited beta-galactosidase, the addition of compatible solutes was unable to restore the enzyme"s kinetic parameters to their uninhibited levels; addition of chaotropic solutes such as urea tended to enhance the effects of these alcohols.	Urea	227-231	galactosidase beta 1	Homo sapiens	50-68
23274723-7	2013	In the case of the ethanol- or propanol-inhibited beta-galactosidase, the addition of compatible solutes was unable to restore the enzyme"s kinetic parameters to their uninhibited levels; addition of chaotropic solutes such as urea tended to enhance the effects of these alcohols.	Alcohols	271-279	galactosidase beta 1	Homo sapiens	50-68
23122115-0	2013	Batch and continuous synthesis of lactulose from whey lactose by immobilized beta-galactosidase.	Lactulose	34-43	galactosidase beta 1	Homo sapiens	77-95
23122115-0	2013	Batch and continuous synthesis of lactulose from whey lactose by immobilized beta-galactosidase.	Lactose	54-61	galactosidase beta 1	Homo sapiens	77-95
23122115-1	2013	In this study, lactulose synthesis from whey lactose was investigated in batch and continuous systems using immobilized beta-galactosidase.	Lactulose	15-24	galactosidase beta 1	Homo sapiens	120-138
23122115-2	2013	In the batch system, the optimal concentration of fructose for lactulose synthesis was 20%, and the effect of galactose, glucose and fructose on beta-galactosidase activity was determined for hydrolysis of whey lactose and the transgalactosylation reaction for lactulose synthesis.	Fructose	50-58	galactosidase beta 1	Homo sapiens	145-163
23122115-2	2013	In the batch system, the optimal concentration of fructose for lactulose synthesis was 20%, and the effect of galactose, glucose and fructose on beta-galactosidase activity was determined for hydrolysis of whey lactose and the transgalactosylation reaction for lactulose synthesis.	Lactulose	63-72	galactosidase beta 1	Homo sapiens	145-163
23122115-2	2013	In the batch system, the optimal concentration of fructose for lactulose synthesis was 20%, and the effect of galactose, glucose and fructose on beta-galactosidase activity was determined for hydrolysis of whey lactose and the transgalactosylation reaction for lactulose synthesis.	Galactose	110-119	galactosidase beta 1	Homo sapiens	145-163
23122115-2	2013	In the batch system, the optimal concentration of fructose for lactulose synthesis was 20%, and the effect of galactose, glucose and fructose on beta-galactosidase activity was determined for hydrolysis of whey lactose and the transgalactosylation reaction for lactulose synthesis.	Glucose	121-128	galactosidase beta 1	Homo sapiens	145-163
23122115-2	2013	In the batch system, the optimal concentration of fructose for lactulose synthesis was 20%, and the effect of galactose, glucose and fructose on beta-galactosidase activity was determined for hydrolysis of whey lactose and the transgalactosylation reaction for lactulose synthesis.	Fructose	133-141	galactosidase beta 1	Homo sapiens	145-163
23122115-2	2013	In the batch system, the optimal concentration of fructose for lactulose synthesis was 20%, and the effect of galactose, glucose and fructose on beta-galactosidase activity was determined for hydrolysis of whey lactose and the transgalactosylation reaction for lactulose synthesis.	Lactose	112-119	galactosidase beta 1	Homo sapiens	145-163
23122115-2	2013	In the batch system, the optimal concentration of fructose for lactulose synthesis was 20%, and the effect of galactose, glucose and fructose on beta-galactosidase activity was determined for hydrolysis of whey lactose and the transgalactosylation reaction for lactulose synthesis.	Lactulose	261-270	galactosidase beta 1	Homo sapiens	145-163
23122115-5	2013	In addition, when immobilized beta-galactosidase was reused for lactulose synthesis, its catalytic activity was retained to the extent of 52.9% after 10 reuses.	Lactulose	64-73	galactosidase beta 1	Homo sapiens	30-48
24078830-5	2013	The results demonstrated that BDMC attenuated oxidative stress-induced senescence-like features which include the induction of an enlarged cellular appearance, higher frequency of senescence-associated beta -galactosidase staining activity, appearance of senescence-associated heterochromatic foci in nuclei, decrease in proliferation capability, and alteration in related molecules such as p16 and retinoblastoma protein.	bisdemethoxycurcumin	30-34	galactosidase beta 1	Homo sapiens	202-221
24406044-4	2013	The activity of beta-galactosidase was measured for functional analysis after miR-138 mimic transfection.	mir-138	78-85	galactosidase beta 1	Homo sapiens	16-34
23046582-3	2013	Here we review GLB1 mutations and clinical features from 65 Brazilian GM1 gangliosidosis patients.	G(M1) Ganglioside	70-73	galactosidase beta 1	Homo sapiens	15-19
22731854-7	2013	MSCs expanded with 20% oxygen contained a greater proportion of senescent cells than those under physiological oxygen levels, indicated by a three to fourfold increase in beta-galactosidase staining.	Oxygen	23-29	galactosidase beta 1	Homo sapiens	171-189
22395907-1	2012	The endogenous beta-galactosidase expressed in intestinal microbes is demonstrated to help humans in lactose usage, and treatment associated with the promotion of beneficial microorganism in the gut is correlated with lactose tolerance.	Lactose	101-108	galactosidase beta 1	Homo sapiens	15-33
22395907-1	2012	The endogenous beta-galactosidase expressed in intestinal microbes is demonstrated to help humans in lactose usage, and treatment associated with the promotion of beneficial microorganism in the gut is correlated with lactose tolerance.	Lactose	218-225	galactosidase beta 1	Homo sapiens	15-33
22817995-0	2012	Monogalactopyranosides of fluorescein and fluorescein methyl ester: synthesis, enzymatic hydrolysis by biotnylated beta-galactosidase, and determination of translational diffusion coefficient.	Fluorescein Methyl ester	42-66	galactosidase beta 1	Homo sapiens	115-133
22922114-0	2012	Immobilization of beta-galactosidase on modified polypropilene membranes.	polypropilene	49-62	galactosidase beta 1	Homo sapiens	18-36
22922114-1	2012	A new immobilized system: beta-galactosidase-modified polypropylene membrane was created.	Polypropylenes	54-67	galactosidase beta 1	Homo sapiens	26-44
22922114-6	2012	beta-Galactosidase was chemically immobilized on the obtained carries by glutaraldehyde.	Glutaral	73-87	galactosidase beta 1	Homo sapiens	0-18
22922114-12	2012	The stability of the free and immobilized beta-galactosidase on the modified membrane 5 with 10% HMDA in aqueous solutions of alcohols - mono-, diol and triol was studied.	3,4-methylenedioxyphenylisobutylamine	97-101	galactosidase beta 1	Homo sapiens	42-60
22922114-12	2012	The stability of the free and immobilized beta-galactosidase on the modified membrane 5 with 10% HMDA in aqueous solutions of alcohols - mono-, diol and triol was studied.	Alcohols	126-134	galactosidase beta 1	Homo sapiens	42-60
22922114-12	2012	The stability of the free and immobilized beta-galactosidase on the modified membrane 5 with 10% HMDA in aqueous solutions of alcohols - mono-, diol and triol was studied.	mono-, diol	137-148	galactosidase beta 1	Homo sapiens	42-60
22922114-12	2012	The stability of the free and immobilized beta-galactosidase on the modified membrane 5 with 10% HMDA in aqueous solutions of alcohols - mono-, diol and triol was studied.	Calcitriol	153-158	galactosidase beta 1	Homo sapiens	42-60
22922114-14	2012	It was concluded that the modified agent - hexamethylenediamine, with long aliphatic chain ensures the best immobilized beta-galactosidase system.	1,6-diaminohexane	43-63	galactosidase beta 1	Homo sapiens	120-138
23057072-0	2012	Enzymatic transglycosylation of PEG brushes by beta-galactosidase.	Polyethylene Glycols	32-35	galactosidase beta 1	Homo sapiens	47-65
23057072-1	2012	Enzymatic transglycosylation has been successfully implemented by beta-galactosidase (beta-Gal) on PEG brushes.	peg brushes	99-110	galactosidase beta 1	Homo sapiens	66-84
23057072-1	2012	Enzymatic transglycosylation has been successfully implemented by beta-galactosidase (beta-Gal) on PEG brushes.	peg brushes	99-110	galactosidase beta 1	Homo sapiens	86-94
22807415-3	2012	Enzymatic reactions between beta-galactosidase and fluorescein di-beta-D-galactopyranoside were succeeded in manipulated droplets, which was confirmed by fluorescence imaging.	fluorescein-digalactoside	51-90	galactosidase beta 1	Homo sapiens	28-46
23013131-9	2012	Exposure of cells to aldosterone for 3 or 5 days increased senescence-associated beta-galactosidase staining, p21 and TNF-alpha mRNA expression and secretion of TNF-alpha into the culture medium.	Aldosterone	21-32	galactosidase beta 1	Homo sapiens	81-99
22817995-0	2012	Monogalactopyranosides of fluorescein and fluorescein methyl ester: synthesis, enzymatic hydrolysis by biotnylated beta-galactosidase, and determination of translational diffusion coefficient.	monogalactopyranosides	0-22	galactosidase beta 1	Homo sapiens	115-133
22817995-0	2012	Monogalactopyranosides of fluorescein and fluorescein methyl ester: synthesis, enzymatic hydrolysis by biotnylated beta-galactosidase, and determination of translational diffusion coefficient.	Fluorescein	26-37	galactosidase beta 1	Homo sapiens	115-133
22941309-0	2012	Galacto-oligosaccharides synthesis from lactose and whey by beta-galactosidase immobilized in PVA.	galacto-oligosaccharides	0-24	galactosidase beta 1	Homo sapiens	60-78
22941309-0	2012	Galacto-oligosaccharides synthesis from lactose and whey by beta-galactosidase immobilized in PVA.	Lactose	40-47	galactosidase beta 1	Homo sapiens	60-78
22941309-1	2012	The synthesis of galacto-oligosaccharides (GOS) by beta-galactosidase immobilized in both polyvinyl alcohol (PVA) lenses and sol-gel carriers was studied and compared with the performance of the free enzyme.	galacto-oligosaccharides	17-41	galactosidase beta 1	Homo sapiens	51-69
22941309-1	2012	The synthesis of galacto-oligosaccharides (GOS) by beta-galactosidase immobilized in both polyvinyl alcohol (PVA) lenses and sol-gel carriers was studied and compared with the performance of the free enzyme.	D-Glucitol-1,6-bisphosphate	43-46	galactosidase beta 1	Homo sapiens	51-69
22941309-2	2012	PVA-immobilized beta-galactosidase retained 95 % of the initial activity after seven repeated uses and retained 51 % of the initial activity after 3 months of storage, while sol-gel-immobilized beta-galactosidase only retained 39 % of the initial activity under storage.	Polyvinyl Alcohol	0-3	galactosidase beta 1	Homo sapiens	16-34
22941309-3	2012	Lactose conversion takes place at a higher rate in the PVA-immobilized beta-galactosidase, while the lowest rate of lactose conversion was noticed with immobilized beta-galactosidase in sol-gel.	Lactose	0-7	galactosidase beta 1	Homo sapiens	71-89
22941309-3	2012	Lactose conversion takes place at a higher rate in the PVA-immobilized beta-galactosidase, while the lowest rate of lactose conversion was noticed with immobilized beta-galactosidase in sol-gel.	Lactose	116-123	galactosidase beta 1	Homo sapiens	164-182
22941309-4	2012	Continuous production of GOS from either lactose or whey, with PVA-immobilized beta-galactosidase, was performed in a packed-bed reactor.	D-Glucitol-1,6-bisphosphate	25-28	galactosidase beta 1	Homo sapiens	79-97
22880882-5	2012	We studied the enzymatic reaction for beta-galactosidase and its substrate (resorufin-beta-D-galactopyranoside) and found K(m) and k(cat) to be 333 +- 130 muM and 64 +- 8 s(-1), respectively, which are in agreement with published data.	resorufin galactopyranoside	76-110	galactosidase beta 1	Homo sapiens	38-56
22821882-2	2012	The enzymatic conversion of this probe by beta-galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd(3+) complex to modulate the (1) H MR signal intensity of the surrounding water molecules.	Fluorine	106-114	galactosidase beta 1	Homo sapiens	42-60
22821882-2	2012	The enzymatic conversion of this probe by beta-galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd(3+) complex to modulate the (1) H MR signal intensity of the surrounding water molecules.	Water	225-230	galactosidase beta 1	Homo sapiens	42-60
22608766-3	2012	4-Aminophenol (PAP) produced by enzyme reaction of beta-gal was introduced into the anode compartment consisting of a comb type of an interdigitated array (IDA) electrode.	4-aminophenol	0-13	galactosidase beta 1	Homo sapiens	51-59
22538800-1	2012	Galactooligosaccharides are sugars composed of 3-10 molecules of galactose and glucose via a transgalactosylation reaction mediated by the enzyme beta-galactosidase.	galactooligosaccharides	0-23	galactosidase beta 1	Homo sapiens	146-164
22538800-1	2012	Galactooligosaccharides are sugars composed of 3-10 molecules of galactose and glucose via a transgalactosylation reaction mediated by the enzyme beta-galactosidase.	Sugars	28-34	galactosidase beta 1	Homo sapiens	146-164
22538800-1	2012	Galactooligosaccharides are sugars composed of 3-10 molecules of galactose and glucose via a transgalactosylation reaction mediated by the enzyme beta-galactosidase.	Galactose	65-74	galactosidase beta 1	Homo sapiens	146-164
22538800-1	2012	Galactooligosaccharides are sugars composed of 3-10 molecules of galactose and glucose via a transgalactosylation reaction mediated by the enzyme beta-galactosidase.	Glucose	79-86	galactosidase beta 1	Homo sapiens	146-164
22724592-7	2012	beta-Galactosidase immobilized on chitosan macro and nanoparticles exhibited excellent operational stability at 37  C, because it was still able to hydrolyze 83.2 and 75.93% of lactose, respectively, after 50 cycles of reuse.	Lactose	177-184	galactosidase beta 1	Homo sapiens	0-18
22784478-7	2012	In this report, we identify a novel enzyme enhancement-agent, N-nonyl-deoxygalactonojirimycin, that enhances the mutant beta-galactosidase activity in the lysosomes of a number of patient cell lines containing a variety of missense mutations.	n-nonyl-deoxygalactonojirimycin	62-93	galactosidase beta 1	Homo sapiens	120-138
22608766-3	2012	4-Aminophenol (PAP) produced by enzyme reaction of beta-gal was introduced into the anode compartment consisting of a comb type of an interdigitated array (IDA) electrode.	Phosphoadenosine Phosphosulfate	15-18	galactosidase beta 1	Homo sapiens	51-59
22817923-0	2012	beta-Galactosidase activity in mixed micelles of imidazolium ionic liquids and sodium dodecylsulfate: A sequential injection kinetic study.	imidazolium	49-60	galactosidase beta 1	Homo sapiens	0-18
22817923-0	2012	beta-Galactosidase activity in mixed micelles of imidazolium ionic liquids and sodium dodecylsulfate: A sequential injection kinetic study.	Sodium Dodecyl Sulfate	79-100	galactosidase beta 1	Homo sapiens	0-18
22817923-1	2012	An automated methodology for the kinetic study of beta-galactosidase activity in sodium dodecylsulfate (SDS)/ionic liquid (IL) mixed micelles was developed.	Sodium Dodecyl Sulfate	81-102	galactosidase beta 1	Homo sapiens	50-68
22817923-1	2012	An automated methodology for the kinetic study of beta-galactosidase activity in sodium dodecylsulfate (SDS)/ionic liquid (IL) mixed micelles was developed.	Sodium Dodecyl Sulfate	104-107	galactosidase beta 1	Homo sapiens	50-68
22817923-12	2012	These results evidenced that the studied ILs can modify the physico-chemical properties of the surfactant solution in a favourable way regarding beta-galactosidase activity being an important achievement for the future implementation of industrial processes catalyzed by this enzyme, mainly the synthesis of glyco-oligossacharides.	glyco-oligossacharides	308-330	galactosidase beta 1	Homo sapiens	145-163
23115978-1	2012	OBJECTIVE: In order to compare the infection of HIV-1 pseudovirus to suspended and adherent cells, Tzmbl cells containing beta-gal (beta-galactosidase) reporter gene were used here to do the analysis.	beta-D-galactose	122-130	galactosidase beta 1	Homo sapiens	132-150
22618082-1	2012	Competitive inhibitors of either alpha-galactosidase (alpha-Gal) or beta-galactosidase (beta-Gal) with high affinity and selectivity have been accessed by exploiting aglycone interactions with conformationally locked sp(2)-iminosugars.	CHEBI:166892	166-174	galactosidase beta 1	Homo sapiens	68-86
22618082-1	2012	Competitive inhibitors of either alpha-galactosidase (alpha-Gal) or beta-galactosidase (beta-Gal) with high affinity and selectivity have been accessed by exploiting aglycone interactions with conformationally locked sp(2)-iminosugars.	CHEBI:166892	166-174	galactosidase beta 1	Homo sapiens	88-96
22618082-1	2012	Competitive inhibitors of either alpha-galactosidase (alpha-Gal) or beta-galactosidase (beta-Gal) with high affinity and selectivity have been accessed by exploiting aglycone interactions with conformationally locked sp(2)-iminosugars.	sp(2)-iminosugars	217-234	galactosidase beta 1	Homo sapiens	68-86
22033734-0	2012	Fluorous iminoalditols act as effective pharmacological chaperones against gene products from GLB1 alleles causing GM1-gangliosidosis and Morquio B disease.	fluorous iminoalditols	0-22	galactosidase beta 1	Homo sapiens	94-98
22618082-1	2012	Competitive inhibitors of either alpha-galactosidase (alpha-Gal) or beta-galactosidase (beta-Gal) with high affinity and selectivity have been accessed by exploiting aglycone interactions with conformationally locked sp(2)-iminosugars.	sp(2)-iminosugars	217-234	galactosidase beta 1	Homo sapiens	88-96
22482531-5	2012	Second, we synthesized a probe for beta-galactosidase (widely used as a reporter of gene expression) by means of beta-galactosyl substitution of the squarylium scaffold; this sensor was able to visualize beta-galactosidase activity both in vitro and in vivo.	squarylium	149-159	galactosidase beta 1	Homo sapiens	35-53
22482531-5	2012	Second, we synthesized a probe for beta-galactosidase (widely used as a reporter of gene expression) by means of beta-galactosyl substitution of the squarylium scaffold; this sensor was able to visualize beta-galactosidase activity both in vitro and in vivo.	squarylium	149-159	galactosidase beta 1	Homo sapiens	204-222
23807909-0	2012	Novel Fe3+-Based 1H MRI beta-Galactosidase Reporter Molecules** There is increasing interest in the development of reporter agents to reveal enzyme activity in vivo using small animal imaging.	ferric sulfate	6-10	galactosidase beta 1	Homo sapiens	24-42
23807909-0	2012	Novel Fe3+-Based 1H MRI beta-Galactosidase Reporter Molecules** There is increasing interest in the development of reporter agents to reveal enzyme activity in vivo using small animal imaging.	Hydrogen	17-19	galactosidase beta 1	Homo sapiens	24-42
23807909-2	2012	Specifically, beta-galactosidase (beta-gal) releases the aglycone, which forms an MR contrast-inducing paramagnetic precipitate in the presence of Fe3+.	CHEBI:166892	57-65	galactosidase beta 1	Homo sapiens	14-32
23807909-2	2012	Specifically, beta-galactosidase (beta-gal) releases the aglycone, which forms an MR contrast-inducing paramagnetic precipitate in the presence of Fe3+.	CHEBI:166892	57-65	galactosidase beta 1	Homo sapiens	14-22
23807909-2	2012	Specifically, beta-galactosidase (beta-gal) releases the aglycone, which forms an MR contrast-inducing paramagnetic precipitate in the presence of Fe3+.	ferric sulfate	147-151	galactosidase beta 1	Homo sapiens	14-32
23807909-2	2012	Specifically, beta-galactosidase (beta-gal) releases the aglycone, which forms an MR contrast-inducing paramagnetic precipitate in the presence of Fe3+.	ferric sulfate	147-151	galactosidase beta 1	Homo sapiens	14-22
23807909-5	2012	We now report the design and successful synthesis of novel analogues together with characterization of 1H MRI contrast based on both T1 and T2 response to beta-gal activity in vitro for the lead agent.	Hydrogen	103-105	galactosidase beta 1	Homo sapiens	155-163
22683026-1	2012	beta-Galactosidase is a hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides; its major application in the food industry is to reduce the content of lactose in lactic products.	beta-galactoside	74-91	galactosidase beta 1	Homo sapiens	0-18
22683026-1	2012	beta-Galactosidase is a hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides; its major application in the food industry is to reduce the content of lactose in lactic products.	Monosaccharides	97-112	galactosidase beta 1	Homo sapiens	0-18
22683026-1	2012	beta-Galactosidase is a hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides; its major application in the food industry is to reduce the content of lactose in lactic products.	Lactose	185-192	galactosidase beta 1	Homo sapiens	0-18
22360414-0	2012	Trans-alpha-xylosidase and trans-beta-galactosidase activities, widespread in plants, modify and stabilize xyloglucan structures.	xyloglucan	107-117	galactosidase beta 1	Homo sapiens	33-51
22360414-10	2012	Thus plants exhibit trans-alpha-xylosidase and trans-beta-galactosidase (but not trans-alpha-fucosidase) activities that graft sugar residues from one xyloglucan oligosaccharide to another.	Sugars	127-132	galactosidase beta 1	Homo sapiens	53-71
22360414-10	2012	Thus plants exhibit trans-alpha-xylosidase and trans-beta-galactosidase (but not trans-alpha-fucosidase) activities that graft sugar residues from one xyloglucan oligosaccharide to another.	xyloglucan oligosaccharide	151-177	galactosidase beta 1	Homo sapiens	53-71
22613224-4	2012	The SA-beta-galactosidase activation was observed both in p53+/+ and p53-/- cells, however the latter ones were less sensitive to the prosenescent activity of curcumin.	Curcumin	159-167	galactosidase beta 1	Homo sapiens	7-25
22588235-5	2012	HEX, GAL, and GLUC activity was assessed on basis of p-nitrophenol release from derivatives of the substrate (HEX: N-acetylglucosamine i N-acetylgalactosamine, GAL from galactose, and GLUC from glucuronide).	4-nitrophenol	53-66	galactosidase beta 1	Homo sapiens	160-163
22588235-5	2012	HEX, GAL, and GLUC activity was assessed on basis of p-nitrophenol release from derivatives of the substrate (HEX: N-acetylglucosamine i N-acetylgalactosamine, GAL from galactose, and GLUC from glucuronide).	1,2,3,4,5,6-hexabromocyclohexane	0-3	galactosidase beta 1	Homo sapiens	160-163
22588235-5	2012	HEX, GAL, and GLUC activity was assessed on basis of p-nitrophenol release from derivatives of the substrate (HEX: N-acetylglucosamine i N-acetylgalactosamine, GAL from galactose, and GLUC from glucuronide).	Galactose	169-178	galactosidase beta 1	Homo sapiens	160-163
22234367-0	2012	Four novel mutations in the beta-galactosidase gene identified in infantile type of GM1 gangliosidosis.	G(M1) Ganglioside	84-87	galactosidase beta 1	Homo sapiens	28-46
22234367-5	2012	Mutations in exons 4 and 6 are in the active site and mutation in exon is in the galactose-binding domain of the beta-galactosidase gene.	Galactose	81-90	galactosidase beta 1	Homo sapiens	113-131
22033734-5	2012	Our previous work on mutations of the beta-galactosidase (beta-gal) gene, causing GM1 gangliosidosis (GM1) and Morquio B disease (MBD), respectively, characterized clinical phenotypes as well as biosynthesis, intracellular transport and subcellular localization of mutants.	G(M1) Ganglioside	82-85	galactosidase beta 1	Homo sapiens	38-56
22033734-5	2012	Our previous work on mutations of the beta-galactosidase (beta-gal) gene, causing GM1 gangliosidosis (GM1) and Morquio B disease (MBD), respectively, characterized clinical phenotypes as well as biosynthesis, intracellular transport and subcellular localization of mutants.	G(M1) Ganglioside	82-85	galactosidase beta 1	Homo sapiens	38-46
23272236-4	2012	Etoposide-treated cells exhibited a senescent phenotype characterized by senile morphology, positive staining for senescence-associated beta-galactosidase, growth arrest and induction of p53 and p21(WAF1/CIP1).	Etoposide	0-9	galactosidase beta 1	Homo sapiens	136-154
22294162-5	2012	N-acetylcysteine, a reactive oxygen species scavenger, not only blocked the oridonin-induced increase in hydrogen peroxide and glutathione depletion, but also blocked apoptosis and senescence induced by oridonin, as evidenced by the decrease in Annexin V and senescence-associated beta-galactosidase- positive cells and the inhibition of oridonin-induced upregulation of p53 and p16 and downregulation of c-Myc.	Acetylcysteine	0-16	galactosidase beta 1	Homo sapiens	281-299
22294162-5	2012	N-acetylcysteine, a reactive oxygen species scavenger, not only blocked the oridonin-induced increase in hydrogen peroxide and glutathione depletion, but also blocked apoptosis and senescence induced by oridonin, as evidenced by the decrease in Annexin V and senescence-associated beta-galactosidase- positive cells and the inhibition of oridonin-induced upregulation of p53 and p16 and downregulation of c-Myc.	oridonin	76-84	galactosidase beta 1	Homo sapiens	281-299
22040225-6	2012	Lectin-fluorescent staining with RCA-I also revealed that PQQ contributed to expression upregulation of the galactosidase beta-1 (Gal beta-1), 4-galactosyltransferase N-acylsphingosine (4-GlcNAc) group in microglia and neurons of the cortex and hippocampal CA2 region.	4-glcnac	186-194	galactosidase beta 1	Homo sapiens	108-128
22320263-5	2012	In contrast to PAA, alpha-amylase and beta-galactosidase were inactivated by PEAMA-b-PEG with the formation of soluble complexes.	peama-b-peg	77-88	galactosidase beta 1	Homo sapiens	38-56
21971529-5	2012	Codons containing more adenines, irrespective of being common or rare, (AAA, ATA and AGA) promoted a higher synthesis of beta-galactosidase (beta-gal) in comparison with those rich in guanines (GGG and AGG) in a wild type transcription-translation system.	Adenine	23-31	galactosidase beta 1	Homo sapiens	121-139
21971529-5	2012	Codons containing more adenines, irrespective of being common or rare, (AAA, ATA and AGA) promoted a higher synthesis of beta-galactosidase (beta-gal) in comparison with those rich in guanines (GGG and AGG) in a wild type transcription-translation system.	Adenine	23-31	galactosidase beta 1	Homo sapiens	121-129
21978926-5	2012	beta-hexosaminidase and beta-galactosidase cleave specific beta-linked terminal residues from a wide range of glycoconjugates and in particular are involved in the stepwise degradation of GM1 to GM3 ganglioside.	G(M1) Ganglioside	188-191	galactosidase beta 1	Homo sapiens	24-42
21978926-5	2012	beta-hexosaminidase and beta-galactosidase cleave specific beta-linked terminal residues from a wide range of glycoconjugates and in particular are involved in the stepwise degradation of GM1 to GM3 ganglioside.	G(M3) Ganglioside	195-210	galactosidase beta 1	Homo sapiens	24-42
21978926-8	2012	The non-random distribution of plasma membrane-associated beta-hexosaminidase and beta-galactosidase and their localization within lipid microdomains, suggest a role of these enzymes in the local reorganization of glycosphingolipid-based signalling units.	Glycosphingolipids	214-231	galactosidase beta 1	Homo sapiens	82-100
22240458-8	2012	However, despite the initiation of apoptotic pathways and transient changes in nuclear morphology, cell death was not observed following aminoglycoside treatment, while administration of CDDP led to significant cell death as determined by flow cytometric measurements; beta-galactosidase analysis ruled out senescence in gentamicin-treated cells.	Cisplatin	187-191	galactosidase beta 1	Homo sapiens	269-287
22219322-7	2012	These findings were supported by the observation that in situ activation of DC before adoptive transfer of beta-galactosidase-specific T cells dramatically increased severity and incidence of EAU.	Water	192-195	galactosidase beta 1	Homo sapiens	107-125
22367946-0	2012	A selected probiotic strain of Lactobacillus fermentum CM33 isolated from breast-fed infants as a potential source of beta-galactosidase for prebiotic oligosaccharide synthesis.	Oligosaccharides	151-166	galactosidase beta 1	Homo sapiens	118-136
22367946-1	2012	Lactic acid bacteria from healthy breast-fed infants were isolated and screened for beta-galactosidase production in MRS broth.	Lactic Acid	0-11	galactosidase beta 1	Homo sapiens	84-102
22367946-1	2012	Lactic acid bacteria from healthy breast-fed infants were isolated and screened for beta-galactosidase production in MRS broth.	mrs broth	117-126	galactosidase beta 1	Homo sapiens	84-102
22367946-6	2012	A preliminary study on the enzymatic synthesis of oligosaccharide using crude beta-galactosidase revealed the capability for oligosaccharide synthesis by the transgalactosylation activity.	Oligosaccharides	50-65	galactosidase beta 1	Homo sapiens	78-96
22367946-6	2012	A preliminary study on the enzymatic synthesis of oligosaccharide using crude beta-galactosidase revealed the capability for oligosaccharide synthesis by the transgalactosylation activity.	Oligosaccharides	125-140	galactosidase beta 1	Homo sapiens	78-96
22213022-3	2012	We synthesized and investigated a series of Gd(3+) and Yb(3+) complexes, including those bearing a self-immolative arm and a sugar unit as selective substrates for beta-galactosidase; we synthesized complex LnL(1), its NH(2) amine derivatives formed after enzymatic cleavage, LnL(2), and two model compounds, LnL(3) and LnL(4).	Sugars	125-130	galactosidase beta 1	Homo sapiens	164-182
23008759-0	2012	Kinetic Analysis of Guanidine Hydrochloride Inactivation of beta-Galactosidase in the Presence of Galactose.	Guanidine	20-43	galactosidase beta 1	Homo sapiens	60-78
23008759-0	2012	Kinetic Analysis of Guanidine Hydrochloride Inactivation of beta-Galactosidase in the Presence of Galactose.	Galactose	98-107	galactosidase beta 1	Homo sapiens	60-78
23008759-1	2012	Inactivation of purified beta-Galactosidase was done with GdnHCl in the absence and presence of varying [galactose] at 50 C and at pH 4.5.	Guanidine	58-64	galactosidase beta 1	Homo sapiens	25-43
23008759-1	2012	Inactivation of purified beta-Galactosidase was done with GdnHCl in the absence and presence of varying [galactose] at 50 C and at pH 4.5.	Galactose	105-114	galactosidase beta 1	Homo sapiens	25-43
22444544-7	2012	To monitor the performance of each technique, the catalytic constants (V(max) and K(m)) of 4-nitro-phenyl-d-galactopyranoside (PNPG) hydrolysis by beta-Gal as well as the inhibition constants (K(i) and IC(50)) by a competitive inhibitor 2-nitrophenyl-1-thio-beta-d-thiogalactopyranoside (ONPTG) were determined.	4-nitrophenylgalactoside	127-131	galactosidase beta 1	Homo sapiens	147-155
22304398-7	2012	We demonstrate pan-analyte immobilization of sized CTAB-laden model proteins (protein G, ovalbumin, bovine serum albumin, beta-galactosidase, lactoferrin) on the EIG with initial capture efficiencies ranging from 21 to 100%.	Cetrimonium	51-55	galactosidase beta 1	Homo sapiens	122-140
22192536-11	2012	Expression of beta-galactosidase as the reporter gene, upon intratumoral injection of DNA, in complex with TMAF, lends credence to specific DNA import and distribution within the tumor tissue that was attributed to high HER2 receptor overexpression in MDA-MB-453 cells.	Tetramethylammonium fluoride	107-111	galactosidase beta 1	Homo sapiens	14-32
22815797-0	2012	Immobilization of beta-galactosidase onto functionalized graphene nano-sheets using response surface methodology and its analytical applications.	Graphite	57-65	galactosidase beta 1	Homo sapiens	18-36
22379801-5	2011	METHODS: By using lactose as the main carbon source and X-Gal as chromogenic agent in the medium, cold-adapted strains producing beta-galactosidase were detected.	Lactose	18-25	galactosidase beta 1	Homo sapiens	129-147
22001501-1	2011	GM1 gangliosidosis, a neurodegenerative disorder, and Morquio B disease, a skeletal disorder, are lysosomal storage disorders caused by inherited defects in the enzyme beta-galactosidase (GLB1; EC 3.1.2.23; MIM #611458).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	188-192
22001501-7	2011	Despite our attempts to improve the extracellular stability of human GLB1 through sequence modification and the use of chemical chaperone N-butyldeoxygalactonojirimycin, the specific enzyme activity remained well below that of mGLB1.	migalastat	138-168	galactosidase beta 1	Homo sapiens	69-73
22379801-5	2011	METHODS: By using lactose as the main carbon source and X-Gal as chromogenic agent in the medium, cold-adapted strains producing beta-galactosidase were detected.	Carbon	38-44	galactosidase beta 1	Homo sapiens	129-147
22379801-5	2011	METHODS: By using lactose as the main carbon source and X-Gal as chromogenic agent in the medium, cold-adapted strains producing beta-galactosidase were detected.	Acetaminophen	56-57	galactosidase beta 1	Homo sapiens	129-147
22379801-5	2011	METHODS: By using lactose as the main carbon source and X-Gal as chromogenic agent in the medium, cold-adapted strains producing beta-galactosidase were detected.	cyclohexenoesculetin-beta-galactoside	58-61	galactosidase beta 1	Homo sapiens	129-147
21973025-3	2011	NrTP6/beta-galactosidase conjugates, prepared by maleimide-based chemistry, were stable and enzymatically active on the standard 4-methylumbelliferyl beta-d-galactopyranoside substrate.	maleimide	49-58	galactosidase beta 1	Homo sapiens	6-24
21803488-2	2011	ATRA induced several biomarkers of cellular senescence including irreversible G1 arrest, morphological changes, senescence-associated beta-galactosidase, and heterochromatin foci in HepG2 cells.	Tretinoin	0-4	galactosidase beta 1	Homo sapiens	134-152
21973025-3	2011	NrTP6/beta-galactosidase conjugates, prepared by maleimide-based chemistry, were stable and enzymatically active on the standard 4-methylumbelliferyl beta-d-galactopyranoside substrate.	methylumbelliferyl	131-149	galactosidase beta 1	Homo sapiens	6-24
21973025-3	2011	NrTP6/beta-galactosidase conjugates, prepared by maleimide-based chemistry, were stable and enzymatically active on the standard 4-methylumbelliferyl beta-d-galactopyranoside substrate.	beta-D-galactopyranoside	150-174	galactosidase beta 1	Homo sapiens	6-24
21973212-4	2011	In MRC-5 cells treated with methylseleninic acid (MSeA, 0-10 muM), depletion of p53 hampers senescence-associated expression of beta-galactosidase, disrupts the otherwise S and G2/M cell cycle arrest, desensitizes such cells to MSeA treatment, and increases genome instability.	methylselenic acid	28-48	galactosidase beta 1	Homo sapiens	128-146
21702056-5	2011	In addition, 1-MCP treatment reduced the activities of fruit-softening enzymes such as pectin methyl esterase, polygalacturonase, endo-1,4-beta-glucanase and beta-galactosidase.	1-methylcyclopropene	13-18	galactosidase beta 1	Homo sapiens	158-176
21943731-3	2011	The proposed method is based on the rapid hydrolysis of lactose using beta-galactosidase and subsequently measuring glucose using a blood glucose meter.	Lactose	56-63	galactosidase beta 1	Homo sapiens	70-88
21909125-7	2011	In contrast, treatment with H2O2 (25, 50 and 100 mumol/L) for 6 d dose-dependently increased beta-galactosidase positive cells.	Hydrogen Peroxide	28-32	galactosidase beta 1	Homo sapiens	93-111
21338333-0	2011	beta-galactosidase determination by an electrochemical biosensor mediated with ferrocene.	ferrocene	79-88	galactosidase beta 1	Homo sapiens	0-18
21338333-4	2011	In this reaction, substrate of glucose oxidase, glucose was provided by the activity of beta-galactosidase in the sample.	Glucose	31-38	galactosidase beta 1	Homo sapiens	88-106
21888996-1	2011	After the complete gene of a beta-galactosidase from human isolate Bifidobacterium breve B24 was isolated by PCR and overexpressed in E. coli, the recombinant beta-galactosidase was purified to homogeneity and characterized for the glycoside transferase (GT) and glycoside hydrolase (GH) activities on lactose.	Lactose	302-309	galactosidase beta 1	Homo sapiens	29-47
21888996-1	2011	After the complete gene of a beta-galactosidase from human isolate Bifidobacterium breve B24 was isolated by PCR and overexpressed in E. coli, the recombinant beta-galactosidase was purified to homogeneity and characterized for the glycoside transferase (GT) and glycoside hydrolase (GH) activities on lactose.	Lactose	302-309	galactosidase beta 1	Homo sapiens	159-177
21888996-7	2011	The results suggest that this recombinant beta-galactosidase derived from a human isolate B. breve B24 may be suitable for both the hydrolysis and synthesis of galacto-oligosaccharides (GOS) in milk and lactose processing.	galacto-oligosaccharides	160-184	galactosidase beta 1	Homo sapiens	42-60
21888996-7	2011	The results suggest that this recombinant beta-galactosidase derived from a human isolate B. breve B24 may be suitable for both the hydrolysis and synthesis of galacto-oligosaccharides (GOS) in milk and lactose processing.	D-Glucitol-1,6-bisphosphate	186-189	galactosidase beta 1	Homo sapiens	42-60
21888996-7	2011	The results suggest that this recombinant beta-galactosidase derived from a human isolate B. breve B24 may be suitable for both the hydrolysis and synthesis of galacto-oligosaccharides (GOS) in milk and lactose processing.	Lactose	203-210	galactosidase beta 1	Homo sapiens	42-60
21607678-3	2011	We encapsulate o-nitrophenyl-beta,D: -galactopyranoside (ONPG) and measure its release by detecting the levels of o-nitrophenol created when the encapsulated ONPG is released and hydrolyzed by beta-galactosidase.	2-nitrophenylgalactoside	15-55	galactosidase beta 1	Homo sapiens	193-211
21601441-5	2011	DNA sequence detection is achieved through a hybridization sandwich of an immobilized complementary probe, the target DNA sequence, and a second complementary probe labeled with beta-galactosidase (beta-GAL); the beta-GAL converts its substrate, 4-aminophenyl-d-galactopyranoside (PAPG), into PAP.	4-aminophenyl-d-galactopyranoside	246-279	galactosidase beta 1	Homo sapiens	178-196
21413094-9	2011	Isolation of nongalloylated and galloylated constituents was successfully achieved through enzymatic transformation of the flavonol mixture using combinations of tannase, beta-glucosidase and beta-galactosidase, followed by chromatographic fractionation.	3-hydroxyflavone	123-131	galactosidase beta 1	Homo sapiens	192-210
21574888-5	2011	When DBS was stored at 37 C the activity of beta-galactosidase dropped to 85% of the initial value after 180 days (p&lt;0.05).	dbs	5-8	galactosidase beta 1	Homo sapiens	44-62
21275828-3	2011	Plain and RhB-modified liposomes were prepared by hydration of lipid films and loaded with FD or with 5-dodecanoylaminofluorescein di-beta-d-galactopyranoside (C(12)FDG), a specific substrate for the intralysosomal beta-galactosidase.	octadecylrhodamine B	10-13	galactosidase beta 1	Homo sapiens	215-233
21275828-3	2011	Plain and RhB-modified liposomes were prepared by hydration of lipid films and loaded with FD or with 5-dodecanoylaminofluorescein di-beta-d-galactopyranoside (C(12)FDG), a specific substrate for the intralysosomal beta-galactosidase.	5-dodecanoylaminofluorescein di-beta-d-galactopyranoside	102-158	galactosidase beta 1	Homo sapiens	215-233
21323488-0	2011	Immobilization of beta-galactosidase on novel polymers having Schiff bases.	Polymers	46-54	galactosidase beta 1	Homo sapiens	18-36
21323488-0	2011	Immobilization of beta-galactosidase on novel polymers having Schiff bases.	Schiff Bases	62-74	galactosidase beta 1	Homo sapiens	18-36
21323488-1	2011	We have developed a strategy to immobilize beta-galactosidase as a model enzyme by using polymeric supports having Schiff bases, which were prepared from (aminomethyl)polystyrene and 2-phenlyindole-3-carboxaldehyde by condensation.	Schiff Bases	115-127	galactosidase beta 1	Homo sapiens	43-61
21323488-1	2011	We have developed a strategy to immobilize beta-galactosidase as a model enzyme by using polymeric supports having Schiff bases, which were prepared from (aminomethyl)polystyrene and 2-phenlyindole-3-carboxaldehyde by condensation.	Ammonia	154-178	galactosidase beta 1	Homo sapiens	43-61
21323488-1	2011	We have developed a strategy to immobilize beta-galactosidase as a model enzyme by using polymeric supports having Schiff bases, which were prepared from (aminomethyl)polystyrene and 2-phenlyindole-3-carboxaldehyde by condensation.	2-phenlyindole-3-carboxaldehyde	183-214	galactosidase beta 1	Homo sapiens	43-61
21323488-2	2011	beta-galactosidase was immobilized onto the new polymer supports via covalent bonds.	Polymers	48-55	galactosidase beta 1	Homo sapiens	0-18
21323488-4	2011	Our results indicate that the (aminomethyl)polystyrene with Schiff bases is most suitable for the immobilization of beta-galactosidase.	Ammonia	30-54	galactosidase beta 1	Homo sapiens	116-134
21323488-4	2011	Our results indicate that the (aminomethyl)polystyrene with Schiff bases is most suitable for the immobilization of beta-galactosidase.	Schiff Bases	60-72	galactosidase beta 1	Homo sapiens	116-134
21601441-5	2011	DNA sequence detection is achieved through a hybridization sandwich of an immobilized complementary probe, the target DNA sequence, and a second complementary probe labeled with beta-galactosidase (beta-GAL); the beta-GAL converts its substrate, 4-aminophenyl-d-galactopyranoside (PAPG), into PAP.	4-aminophenyl-d-galactopyranoside	246-279	galactosidase beta 1	Homo sapiens	198-206
21601441-5	2011	DNA sequence detection is achieved through a hybridization sandwich of an immobilized complementary probe, the target DNA sequence, and a second complementary probe labeled with beta-galactosidase (beta-GAL); the beta-GAL converts its substrate, 4-aminophenyl-d-galactopyranoside (PAPG), into PAP.	4-aminophenyl-d-galactopyranoside	246-279	galactosidase beta 1	Homo sapiens	213-221
21601441-5	2011	DNA sequence detection is achieved through a hybridization sandwich of an immobilized complementary probe, the target DNA sequence, and a second complementary probe labeled with beta-galactosidase (beta-GAL); the beta-GAL converts its substrate, 4-aminophenyl-d-galactopyranoside (PAPG), into PAP.	((2R,3S,4R,5R)-3-(((((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)oxidophosphoryl)oxy)-5-(6-amino-9H-purin-9-yl)-4-hydroxytetrahydrofuran-2-yl)methyl phosphate	281-285	galactosidase beta 1	Homo sapiens	198-206
21601441-5	2011	DNA sequence detection is achieved through a hybridization sandwich of an immobilized complementary probe, the target DNA sequence, and a second complementary probe labeled with beta-galactosidase (beta-GAL); the beta-GAL converts its substrate, 4-aminophenyl-d-galactopyranoside (PAPG), into PAP.	((2R,3S,4R,5R)-3-(((((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)oxidophosphoryl)oxy)-5-(6-amino-9H-purin-9-yl)-4-hydroxytetrahydrofuran-2-yl)methyl phosphate	281-285	galactosidase beta 1	Homo sapiens	213-221
21497194-2	2011	Here we report the beta-galactosidase gene (GLB1) mutation analysis of 21 unrelated GM1 gangliosidosis patients, and of 4 Morquio B patients, of whom two are brothers.	G(M1) Ganglioside	84-87	galactosidase beta 1	Homo sapiens	44-48
21700008-8	2011	The 2 most active enzymes, as determined by the beta-galactosidase assay, hydrolyzed over 98% of the lactose in 24h at 2 C using the supplier"s recommended dosage.	Lactose	101-108	galactosidase beta 1	Homo sapiens	48-66
21520340-4	2011	We have previously reported the chaperone effect of N-octyl-4-epi-beta-valienamine (NOEV) on mutant beta-galactosidase proteins.	N-octyl-beta-valienamine	52-82	galactosidase beta 1	Homo sapiens	100-118
21478297-4	2011	Among the compounds tested under UVA irradiation, methylene blue, neutral red and dichlorobenzidine showed only a slight induction of beta-galactosidase activity, whereas 8-methoxypsoralen, chloropromazine and 9,10-dimethylbenzanthracene showed a significant increase in the relative LacZ level as an indicator of genotoxicity.	Methylene Blue	50-64	galactosidase beta 1	Homo sapiens	134-152
21464199-2	2011	We have demonstrated that depletion of CTP induced by cyclopentenyl cytosine (CPEC; NSC 375575), a specific inhibitor of the enzyme CTP synthetase, induces irreversible growth arrest and senescence characterized by altered morphology and expression of senescence-associated beta-galactosidase activity in MCF-7 breast cancer cells expressing wild-type p53.	cyclopentenyl cytosine	54-76	galactosidase beta 1	Homo sapiens	274-292
21478297-4	2011	Among the compounds tested under UVA irradiation, methylene blue, neutral red and dichlorobenzidine showed only a slight induction of beta-galactosidase activity, whereas 8-methoxypsoralen, chloropromazine and 9,10-dimethylbenzanthracene showed a significant increase in the relative LacZ level as an indicator of genotoxicity.	Dichlorobenzidine	82-99	galactosidase beta 1	Homo sapiens	134-152
21464199-2	2011	We have demonstrated that depletion of CTP induced by cyclopentenyl cytosine (CPEC; NSC 375575), a specific inhibitor of the enzyme CTP synthetase, induces irreversible growth arrest and senescence characterized by altered morphology and expression of senescence-associated beta-galactosidase activity in MCF-7 breast cancer cells expressing wild-type p53.	cyclopentenyl cytosine	78-82	galactosidase beta 1	Homo sapiens	274-292
21357660-4	2011	Exposure of human endothelial cells to high glucose (22 mM) for 3 days increased senescence-associated-beta-galactosidase activity, a senescence marker, and decreased telomerase activity, a replicative senescence marker.	Glucose	44-51	galactosidase beta 1	Homo sapiens	103-121
21627131-3	2011	In this approach, cationic gold nanoparticles (NPs) featuring quaternary amine headgroups are electrostatically bound to an enzyme [beta-galactosidase (beta-Gal)], inhibiting enzyme activity.	quaternary amine	62-78	galactosidase beta 1	Homo sapiens	132-150
21627131-3	2011	In this approach, cationic gold nanoparticles (NPs) featuring quaternary amine headgroups are electrostatically bound to an enzyme [beta-galactosidase (beta-Gal)], inhibiting enzyme activity.	quaternary amine	62-78	galactosidase beta 1	Homo sapiens	152-160
21460750-5	2011	We showed that overexpression of miR-125b induced typical senescent cell morphology, including increased cytoplasmatic/nucleus ratio and intensive cytoplasmatic beta-galactosidase expression.	mir-125b	33-41	galactosidase beta 1	Homo sapiens	161-179
21677876-2	2011	Here we show that androgen deprivation therapy (ADT), a widely used treatment for advanced prostate cancer, induces a senescence-associated secretory phenotype in prostate cancer epithelial cells, indicated by increases in senescence-associated beta-galactosidase activity, heterochromatin protein 1beta foci, and expression of cathepsin B and insulin-like growth factor binding protein 3.	adt	48-51	galactosidase beta 1	Homo sapiens	245-263
21663649-11	2011	However, after repeated NA exposure, BrdU induced epithelial cell (Clara cell) senescence, as demonstrated by a DNA damage response, p21 overexpression, increased senescence-associated beta-galactosidase activity, and growth arrest, which resulted in impaired epithelial regeneration.	Bromodeoxyuridine	37-41	galactosidase beta 1	Homo sapiens	185-203
21191810-4	2011	PGE(2) treatment induces cellular senescence, as determined by a decrease in cell proliferation and an increase in senescence-associated beta-galactosidase staining.	Prostaglandins E	0-3	galactosidase beta 1	Homo sapiens	137-155
21460363-1	2011	A series of experiments were performed, in which p-nitrophenyl-beta-D-cellobioside (PNPC) was hydrolyzed by 1, 4-beta-D-glucan-cellobiohydrolase (CBHI: EC 3.2.1.91), and O-nitrophenyl-beta-D-galactoside (ONPG) was hydrolyzed by beta-galactosidase (EC 3.2.1.23) under different combinations of temperature and time period.	4-nitrophenyl beta-cellobioside	49-82	galactosidase beta 1	Homo sapiens	228-246
21277918-3	2011	These water-soluble PAAs efficiently condense beta-galactosidase by self-assembly into nanoscaled and positively-charged complexes.	Water	6-11	galactosidase beta 1	Homo sapiens	46-64
21539811-5	2011	We found that CPT- and DOX-induced morphology changes and increases in senescence-associated beta-galactosidase staining were significantly inhibited in EJ human bladder cancer cells and H1299 human lung cancer cells overexpressing HA-Nek6.	Camptothecin	14-17	galactosidase beta 1	Homo sapiens	93-111
21539811-5	2011	We found that CPT- and DOX-induced morphology changes and increases in senescence-associated beta-galactosidase staining were significantly inhibited in EJ human bladder cancer cells and H1299 human lung cancer cells overexpressing HA-Nek6.	Doxorubicin	23-26	galactosidase beta 1	Homo sapiens	93-111
21226520-3	2011	Here we choose eosin as the photosensitizing chromophore showing 11-fold more production of ((1)O(2)) than fluorescein and about 5-fold efficiency in CALI of beta-galactosidase by using an eosin-labeled anti-beta-galactosidase antibody compared with the fluorescein-labeled one.	Eosine Yellowish-(YS)	15-20	galactosidase beta 1	Homo sapiens	158-176
21226520-3	2011	Here we choose eosin as the photosensitizing chromophore showing 11-fold more production of ((1)O(2)) than fluorescein and about 5-fold efficiency in CALI of beta-galactosidase by using an eosin-labeled anti-beta-galactosidase antibody compared with the fluorescein-labeled one.	Eosine Yellowish-(YS)	15-20	galactosidase beta 1	Homo sapiens	208-226
21226520-3	2011	Here we choose eosin as the photosensitizing chromophore showing 11-fold more production of ((1)O(2)) than fluorescein and about 5-fold efficiency in CALI of beta-galactosidase by using an eosin-labeled anti-beta-galactosidase antibody compared with the fluorescein-labeled one.	Eosine Yellowish-(YS)	189-194	galactosidase beta 1	Homo sapiens	158-176
21226520-3	2011	Here we choose eosin as the photosensitizing chromophore showing 11-fold more production of ((1)O(2)) than fluorescein and about 5-fold efficiency in CALI of beta-galactosidase by using an eosin-labeled anti-beta-galactosidase antibody compared with the fluorescein-labeled one.	Eosine Yellowish-(YS)	189-194	galactosidase beta 1	Homo sapiens	208-226
21226520-3	2011	Here we choose eosin as the photosensitizing chromophore showing 11-fold more production of ((1)O(2)) than fluorescein and about 5-fold efficiency in CALI of beta-galactosidase by using an eosin-labeled anti-beta-galactosidase antibody compared with the fluorescein-labeled one.	Fluorescein	254-265	galactosidase beta 1	Homo sapiens	158-176
21460363-1	2011	A series of experiments were performed, in which p-nitrophenyl-beta-D-cellobioside (PNPC) was hydrolyzed by 1, 4-beta-D-glucan-cellobiohydrolase (CBHI: EC 3.2.1.91), and O-nitrophenyl-beta-D-galactoside (ONPG) was hydrolyzed by beta-galactosidase (EC 3.2.1.23) under different combinations of temperature and time period.	4-nitrophenyl beta-cellobioside	84-88	galactosidase beta 1	Homo sapiens	228-246
21740754-7	2011	Ultrasonic destruction of microbubbles during calcium phosphate precipitation gene transfection enhanced beta-galactosidase activity nearly 8-fold compared with calcium phosphate precipitation gene transfection alone ((111.35 +- 11.21) U/g protein vs. (14.13 +- 2.58) U/g protein, P &lt; 0.01).	calcium phosphate	46-63	galactosidase beta 1	Homo sapiens	105-123
21481687-4	2011	We further showed that resveratrol-induced hypertrophic cells expressed senescence-associated-beta-galactosidase, suggesting that resveratrol-induced cellular senescence in glioma cells.	Resveratrol	23-34	galactosidase beta 1	Homo sapiens	94-112
21481687-4	2011	We further showed that resveratrol-induced hypertrophic cells expressed senescence-associated-beta-galactosidase, suggesting that resveratrol-induced cellular senescence in glioma cells.	Resveratrol	130-141	galactosidase beta 1	Homo sapiens	94-112
21270817-7	2011	Pretreatment with CV11974 (100 nM) or tempol (3 mM) abolished Ang II-induced astrocyte beta-galactosidase staining.	candesartan	18-25	galactosidase beta 1	Homo sapiens	87-105
21270817-7	2011	Pretreatment with CV11974 (100 nM) or tempol (3 mM) abolished Ang II-induced astrocyte beta-galactosidase staining.	tempol	38-44	galactosidase beta 1	Homo sapiens	87-105
21280615-6	2011	Furthermore, in situ enzyme kinetic measurements of the beta-galactosidase-catalyzed hydrolysis of resorufin-beta-d-galactopyranoside were performed to demonstrate the application potential of our simple, time-effective, and low sample volume microfluidic device.	resorufin galactopyranoside	99-133	galactosidase beta 1	Homo sapiens	56-74
20967490-0	2011	The use of disaccharides in inhibiting enzymatic activity loss and secondary structure changes in freeze-dried beta-galactosidase during storage.	Disaccharides	11-24	galactosidase beta 1	Homo sapiens	111-129
21103910-2	2011	A supplemental beta-galactosidase administered orally to treat lactose intolerance was conjugated to 40 kDa, branched polyethylene glycol (PEG).	Lactose	63-70	galactosidase beta 1	Homo sapiens	15-33
21103910-2	2011	A supplemental beta-galactosidase administered orally to treat lactose intolerance was conjugated to 40 kDa, branched polyethylene glycol (PEG).	branched polyethylene glycol	109-137	galactosidase beta 1	Homo sapiens	15-33
21103910-2	2011	A supplemental beta-galactosidase administered orally to treat lactose intolerance was conjugated to 40 kDa, branched polyethylene glycol (PEG).	Polyethylene Glycols	139-142	galactosidase beta 1	Homo sapiens	15-33
21468560-10	2011	The AngII + losartan group displayed longer telomere lengths, further reduced beta-galactosidase staining and decreased P53 and P21 expression compared to the AngII group.	Losartan	12-20	galactosidase beta 1	Homo sapiens	78-96
20967490-1	2011	PURPOSE: The purpose of this study is to show how disaccharides differ in their ability to protect lyophilized beta-galactosidase from enzymatic activity loss and secondary structure changes during storage.	Disaccharides	50-63	galactosidase beta 1	Homo sapiens	111-129
20967490-4	2011	RESULTS: The enzymatic activity of beta-galactosidase decreased more slowly in lyophilizates containing trehalose or melibiose at 2:1 excipient/protein weight ratio when compared to those containing sucrose or cellobiose.	Trehalose	104-113	galactosidase beta 1	Homo sapiens	35-53
20967490-4	2011	RESULTS: The enzymatic activity of beta-galactosidase decreased more slowly in lyophilizates containing trehalose or melibiose at 2:1 excipient/protein weight ratio when compared to those containing sucrose or cellobiose.	Sucrose	199-206	galactosidase beta 1	Homo sapiens	35-53
20967490-4	2011	RESULTS: The enzymatic activity of beta-galactosidase decreased more slowly in lyophilizates containing trehalose or melibiose at 2:1 excipient/protein weight ratio when compared to those containing sucrose or cellobiose.	Cellobiose	210-220	galactosidase beta 1	Homo sapiens	35-53
21190955-4	2011	Aldosterone induced senescence-like changes in the kidney, exhibited by increased expression of the senescence-associated beta-galactosidase, overexpression of p53 and cyclin-dependent kinase inhibitor (p21), and decreased expression of SIRT1.	Aldosterone	0-11	galactosidase beta 1	Homo sapiens	122-140
21044612-5	2011	Furthermore, DAC treatment induced cellular senescence and autophagy as shown by beta-galactosidase staining and by autophagosome formation, respectively.	Decitabine	13-16	galactosidase beta 1	Homo sapiens	81-99
21146809-3	2011	Among the compounds synthesized, the polyhydroxy 7-butyl azepane (compound 3), which possessed the R-configuration at C-7 position, is shown to give potent inhibition against beta-galactosidase (IC(50)= 3 microM).	polyhydroxy 7-butyl azepane	37-64	galactosidase beta 1	Homo sapiens	175-193
21500551-7	2011	RESULTS: Compared with control group, percentage of positive cells of senescence-associated beta-galactosidase staining increased significantly in high glucose groups.	Glucose	152-159	galactosidase beta 1	Homo sapiens	92-110
21500551-11	2011	KU55993, an inhibitor of ATM, significantly reduced the levels of gamma-H2AX, phosphorylated P53 protein, and positive rate of senescence-associated beta-galactosidase staining.	ku55993	0-7	galactosidase beta 1	Homo sapiens	149-167
20948431-9	2011	Low concentrations of boningmycin led to a senescent phenotype with an increase in senescence-associated beta-galactosidase activity and the time-dependent increase of p21, p27, and p53 expressions from 48 to120 h. Taken together, the results showed that boningmycin exhibits potent antitumor actions through the induction of apoptosis and cellular senescence.	boningmycin	22-33	galactosidase beta 1	Homo sapiens	105-123
21190955-6	2011	Furthermore, aldosterone induced similar changes in senescence-associated beta-galactosidase, p21, and SIRT1 expression in cultured human proximal tubular cells, which were normalized by an antioxidant, N-acetyl L-cysteine, or gene silencing of MR. Aldosterone significantly delayed wound healing and reduced the number of proliferating human proximal tubular cells, while gene silencing of p21 diminished the effects, suggesting impaired recovery from tubular damage.	Aldosterone	13-24	galactosidase beta 1	Homo sapiens	74-92
21059349-5	2011	RESULTS: Double dilution tests showed a clear nonlinearity, suggesting that antibody interference not related to heterophilic antibodies had occurred; false-positive concentrations of cyclosporin obtained when using an antibody-conjugated to beta-galactosidase suggested the presence of endogenous antibodies directed against beta-galactosidase.	Cyclosporine	184-195	galactosidase beta 1	Homo sapiens	242-260
21059349-5	2011	RESULTS: Double dilution tests showed a clear nonlinearity, suggesting that antibody interference not related to heterophilic antibodies had occurred; false-positive concentrations of cyclosporin obtained when using an antibody-conjugated to beta-galactosidase suggested the presence of endogenous antibodies directed against beta-galactosidase.	Cyclosporine	184-195	galactosidase beta 1	Homo sapiens	326-344
20829890-0	2011	Enhanced tumor therapy using vaccinia virus strain GLV-1h68 in combination with a beta-galactosidase-activatable prodrug seco-analog of duocarmycin SA.	duocarmycin SA	136-150	galactosidase beta 1	Homo sapiens	82-100
21084274-7	2011	Brief exposure of apoptosis-resistant renal, lung and prostate cancer cell lines to ABT-737, although not capable of inducing cell death, causes the induction of senescence-associated beta-galactosidase and inhibition of cell growth consistent with the induction of cellular senescence.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	84-87	galactosidase beta 1	Homo sapiens	184-202
20829890-4	2011	Here, the lacZ-carrying vaccinia virus (VACV) strain GLV-1h68 was used in combination with a beta-galactosidase-activatable prodrug derived from a seco-analog of the natural antibiotic duocarmycin SA.	duocarmycin SA	185-199	galactosidase beta 1	Homo sapiens	93-111
21054932-4	2011	It was found that the frequency of cycling cells was significantly increased, while senescence markers such as beta-galactosidase activities and p16(INK4a) expression level were markedly reduced in MSCs under low-glucose culture condition.	Glucose	213-220	galactosidase beta 1	Homo sapiens	111-129
22043305-5	2011	After being exposed to 50 microM H(2)O(2) for 2 weeks, HLECs senescent-morphological changes appeared, cell viability decreased dramatically, cell proliferation reduced from 37.4% to 16.1%, and senescence-associated beta-galactosidase activity increased from 0 to 90.3%.	Hydrogen Peroxide	33-41	galactosidase beta 1	Homo sapiens	216-234
21671223-2	2011	In developing structures derived from a null mutant for smdA (a smdA- strain), prestalk patterning is normal, but using a prespore lacZ reporter fusion, there is ectopic accumulation of beta-galactosidase in the prestalk region.	smda	56-60	galactosidase beta 1	Homo sapiens	186-204
20204527-7	2010	The synthesis of beta-galactosidase from the PDI2-lacZ fusion gene was markedly enhanced in the Pap1-positive KP1 cells by SNP and nitrogen starvation.	Nitrogen	131-139	galactosidase beta 1	Homo sapiens	17-35
21234407-2	2010	The use of beta-galactosidase for the hydrolysis of lactose in milk and whey is one of the promising enzymatic applications in food and dairy processing industries.	Lactose	52-59	galactosidase beta 1	Homo sapiens	11-29
20549306-4	2010	In A172 cells, BeSO(4) produced a G(0)/G(1)-phase cell cycle arrest and increased expression of senescence-associated beta-galactosidase, an enzymatic marker of senescence.	beso	15-19	galactosidase beta 1	Homo sapiens	118-136
21248428-4	2010	In this study, thus, glycophorin A which is a highly glycosylated sialoglycoprotein with approximately 12 O-glycans was sequentially treated with sialidase and beta-galactosidase to remove sialic acid and galactose residues.	o-glycans	106-115	galactosidase beta 1	Homo sapiens	160-178
21248428-4	2010	In this study, thus, glycophorin A which is a highly glycosylated sialoglycoprotein with approximately 12 O-glycans was sequentially treated with sialidase and beta-galactosidase to remove sialic acid and galactose residues.	N-Acetylneuraminic Acid	189-200	galactosidase beta 1	Homo sapiens	160-178
21248428-4	2010	In this study, thus, glycophorin A which is a highly glycosylated sialoglycoprotein with approximately 12 O-glycans was sequentially treated with sialidase and beta-galactosidase to remove sialic acid and galactose residues.	Galactose	205-214	galactosidase beta 1	Homo sapiens	160-178
20204527-8	2010	However, the enhancement in the synthesis of beta-galactosidase from the PDI2-lacZ fusion gene by SNP and nitrogen starvation appeared to be relatively reduced in the Pap1-negative TP108-3C cells than in the Pap1-positive KP1 cells.	Nitrogen	106-114	galactosidase beta 1	Homo sapiens	45-63
20435074-1	2010	BACKGROUND: Peroral beta-galactosidase preparations for the management of lactose intolerance need to be administered in large doses (1500 to 6000 U) immediately before or together with a lactose-containing meal.	Lactose	74-81	galactosidase beta 1	Homo sapiens	20-38
20826101-3	2010	We have previously reported that N-octyl-4-epi-beta-valienamine (NOEV), a chemical chaperone compound, stabilized various mutant human beta-gal proteins and increased residual enzyme activities in cultured fibroblasts from human patients.	N-octyl-beta-valienamine	33-63	galactosidase beta 1	Homo sapiens	135-143
20435074-1	2010	BACKGROUND: Peroral beta-galactosidase preparations for the management of lactose intolerance need to be administered in large doses (1500 to 6000 U) immediately before or together with a lactose-containing meal.	Lactose	188-195	galactosidase beta 1	Homo sapiens	20-38
20435074-4	2010	METHODS: Spray-dried poly(D,L-lactide-co-glycolide) (PLGA) particles with 2.78+-1.05microm in diameter were functionalized with beta-galactosidase from Kluyveromyces lactis and WGA using different types of spacers (polyethyleneimine, hexamethylene diamine, 6-aminocaproic acid) and coupling methods (carbodiimide and glutaraldehyde).	Polylactic Acid-Polyglycolic Acid Copolymer	21-51	galactosidase beta 1	Homo sapiens	128-146
20435074-4	2010	METHODS: Spray-dried poly(D,L-lactide-co-glycolide) (PLGA) particles with 2.78+-1.05microm in diameter were functionalized with beta-galactosidase from Kluyveromyces lactis and WGA using different types of spacers (polyethyleneimine, hexamethylene diamine, 6-aminocaproic acid) and coupling methods (carbodiimide and glutaraldehyde).	aziridine	215-232	galactosidase beta 1	Homo sapiens	128-146
20435074-4	2010	METHODS: Spray-dried poly(D,L-lactide-co-glycolide) (PLGA) particles with 2.78+-1.05microm in diameter were functionalized with beta-galactosidase from Kluyveromyces lactis and WGA using different types of spacers (polyethyleneimine, hexamethylene diamine, 6-aminocaproic acid) and coupling methods (carbodiimide and glutaraldehyde).	1,6-diaminohexane	234-255	galactosidase beta 1	Homo sapiens	128-146
20435074-4	2010	METHODS: Spray-dried poly(D,L-lactide-co-glycolide) (PLGA) particles with 2.78+-1.05microm in diameter were functionalized with beta-galactosidase from Kluyveromyces lactis and WGA using different types of spacers (polyethyleneimine, hexamethylene diamine, 6-aminocaproic acid) and coupling methods (carbodiimide and glutaraldehyde).	Aminocaproic Acid	257-276	galactosidase beta 1	Homo sapiens	128-146
20435074-4	2010	METHODS: Spray-dried poly(D,L-lactide-co-glycolide) (PLGA) particles with 2.78+-1.05microm in diameter were functionalized with beta-galactosidase from Kluyveromyces lactis and WGA using different types of spacers (polyethyleneimine, hexamethylene diamine, 6-aminocaproic acid) and coupling methods (carbodiimide and glutaraldehyde).	Carbodiimides	300-312	galactosidase beta 1	Homo sapiens	128-146
20435074-4	2010	METHODS: Spray-dried poly(D,L-lactide-co-glycolide) (PLGA) particles with 2.78+-1.05microm in diameter were functionalized with beta-galactosidase from Kluyveromyces lactis and WGA using different types of spacers (polyethyleneimine, hexamethylene diamine, 6-aminocaproic acid) and coupling methods (carbodiimide and glutaraldehyde).	Glutaral	317-331	galactosidase beta 1	Homo sapiens	128-146
20435074-10	2010	CONCLUSIONS: For the delivery of beta-galactosidase WGA-targeted PLGA microparticles were prepared, which represent promising candidates for a convenient biomimetic treatment regimen of lactose intolerance.	Lactose	186-193	galactosidase beta 1	Homo sapiens	33-51
20175788-1	2010	GM1 gangliosidosis manifests with progressive psychomotor deterioration and dysostosis of infantile, juvenile, or adult onset, caused by alterations in the structural gene coding for lysosomal acid beta-galactosidase (GLB1).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	193-216
20925095-0	2010	Difluorotetrahydropyridothiazinone: a selective beta-galactosidase inhibitor.	difluorotetrahydropyridothiazinone	0-34	galactosidase beta 1	Homo sapiens	48-66
20925095-1	2010	Selective difluorination, introducing a lactame moiety (instead of an amine) and a double bond in a trihydroxy-2-thiaquinolizidine derivative reverses the selectivity of the glycosidase inhibitor - a selective inhibitor for an alpha-glucosidase is altered into an excellent, competitive inhibitor for a beta-galactosidase.	lactame	40-47	galactosidase beta 1	Homo sapiens	303-321
20925095-1	2010	Selective difluorination, introducing a lactame moiety (instead of an amine) and a double bond in a trihydroxy-2-thiaquinolizidine derivative reverses the selectivity of the glycosidase inhibitor - a selective inhibitor for an alpha-glucosidase is altered into an excellent, competitive inhibitor for a beta-galactosidase.	Amines	70-75	galactosidase beta 1	Homo sapiens	303-321
20925095-1	2010	Selective difluorination, introducing a lactame moiety (instead of an amine) and a double bond in a trihydroxy-2-thiaquinolizidine derivative reverses the selectivity of the glycosidase inhibitor - a selective inhibitor for an alpha-glucosidase is altered into an excellent, competitive inhibitor for a beta-galactosidase.	trihydroxy-2-thiaquinolizidine	100-130	galactosidase beta 1	Homo sapiens	303-321
33467831-5	2010	A GOS can be produced by a series of enzymatic reactions catalyzed by beta-galactosidase, where the glycosyl group of one or more D-galactosyl units is transferred onto the D-galactose moiety of lactose, in a process known as transgalactosylation.	D-Glucitol-1,6-bisphosphate	2-5	galactosidase beta 1	Homo sapiens	70-88
33467831-5	2010	A GOS can be produced by a series of enzymatic reactions catalyzed by beta-galactosidase, where the glycosyl group of one or more D-galactosyl units is transferred onto the D-galactose moiety of lactose, in a process known as transgalactosylation.	Galactose	173-184	galactosidase beta 1	Homo sapiens	70-88
33467831-5	2010	A GOS can be produced by a series of enzymatic reactions catalyzed by beta-galactosidase, where the glycosyl group of one or more D-galactosyl units is transferred onto the D-galactose moiety of lactose, in a process known as transgalactosylation.	Lactose	177-184	galactosidase beta 1	Homo sapiens	70-88
33467831-6	2010	Microbes can be used as a source for the beta-galactosidase enzyme or as agents to produce GOS molecules.	D-Glucitol-1,6-bisphosphate	91-94	galactosidase beta 1	Homo sapiens	41-59
33467831-7	2010	Commercial beta-galactosidase enzymes also do have a great potential for their use in GOS synthesis.	D-Glucitol-1,6-bisphosphate	86-89	galactosidase beta 1	Homo sapiens	11-29
20920281-0	2010	Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity.	G(M1) Ganglioside	75-78	galactosidase beta 1	Homo sapiens	12-30
20920281-1	2010	BACKGROUND: GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease caused by deficiency of acid beta-galactosidase (GLB1; EC3.2.1.23).	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	138-142
20920281-1	2010	BACKGROUND: GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease caused by deficiency of acid beta-galactosidase (GLB1; EC3.2.1.23).	G(M1) Ganglioside	32-35	galactosidase beta 1	Homo sapiens	138-142
20920281-2	2010	Here, we identify three novel mutations in the GLB1 gene from two Han Chinese patients with GM1 that appear correlated with clinical phenotype.	G(M1) Ganglioside	92-95	galactosidase beta 1	Homo sapiens	47-51
20695638-3	2010	In control samples, maltose and maltotriose were hydrolyzed by alpha-glucosidase and not beta-galactosidase, whereas lactose was resistant to alpha-glucosidase but was hydrolyzed with beta-galactosidase.	Lactose	117-124	galactosidase beta 1	Homo sapiens	184-202
20483570-9	2010	The assay of enzymatic activity of beta-galactosidase in hydrolysis of o-nitrophenyl-beta-d-galactopyranoside (ONPG) indicated that over 90% of the protein recovered from the microspheres was active.	2-nitrophenylgalactoside	71-109	galactosidase beta 1	Homo sapiens	35-53
20175788-1	2010	GM1 gangliosidosis manifests with progressive psychomotor deterioration and dysostosis of infantile, juvenile, or adult onset, caused by alterations in the structural gene coding for lysosomal acid beta-galactosidase (GLB1).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	218-222
20175788-3	2010	More than 100 sequence alterations in the GLB1 gene have been identified so far, but only few could be proven to be predictive for one of the GM1 gangliosidosis subtypes or MBD.	G(M1) Ganglioside	142-145	galactosidase beta 1	Homo sapiens	42-46
20615703-5	2010	As proof of concept, we designed and synthesized a xanthene-based photosensitizer, TGI-betaGal, whose oxidative stress induction ability is switched on following hydrolysis reaction with beta-galactosidase, a widely used gene marker.	Xanthenes	51-59	galactosidase beta 1	Homo sapiens	187-205
20812435-0	2010	Falsely elevated tacrolimus levels caused by immunoassay interference secondary to beta-galactosidase antibodies in an infected liver transplant recipient.	Tacrolimus	17-27	galactosidase beta 1	Homo sapiens	83-101
20398956-6	2010	RESULTS: High glucose significantly increased number of beta-galactosidase-positive stained cells, inhibited telomerase activity, increased proportion of cells in the G(0)/G(1) phase and reduced proportion in the S phase, and decreased NO synthesis.	Glucose	14-21	galactosidase beta 1	Homo sapiens	56-74
20452981-6	2010	Several senescence-associated (SA) phenotypes including increased SA-beta-galactosidase activities, decreased bromodeoxyuridine incorporation, and increased SA-heterochromatin foci formation were also observed in PTTG1-expressing cells, indicating that PTTG1 overexpression induced a senescent phenotype in normal cells.	sa	31-33	galactosidase beta 1	Homo sapiens	69-87
20409738-2	2010	Its main gene product, human acid beta-galactosidase (beta-Gal) degrades two functionally important molecules, G(M1)-ganglioside and keratan sulfate in brain and connective tissues, respectively.	Gangliosides	117-128	galactosidase beta 1	Homo sapiens	29-52
20572145-0	2010	S-Gal, a novel 1H MRI reporter for beta-galactosidase.	Hydrogen	15-17	galactosidase beta 1	Homo sapiens	35-53
20572145-3	2010	3,4-Cyclohexenoesculetin beta-D-galactopyranoside (S-Gal) is a commercial histologic stain, which forms a black precipitate in the presence of beta-gal and ferric ions, suggesting potential detectability by MRI.	cyclohexenoesculetin-beta-galactoside	0-49	galactosidase beta 1	Homo sapiens	143-151
20572145-3	2010	3,4-Cyclohexenoesculetin beta-D-galactopyranoside (S-Gal) is a commercial histologic stain, which forms a black precipitate in the presence of beta-gal and ferric ions, suggesting potential detectability by MRI.	cyclohexenoesculetin-beta-galactoside	51-56	galactosidase beta 1	Homo sapiens	143-151
20409738-2	2010	Its main gene product, human acid beta-galactosidase (beta-Gal) degrades two functionally important molecules, G(M1)-ganglioside and keratan sulfate in brain and connective tissues, respectively.	Gangliosides	117-128	galactosidase beta 1	Homo sapiens	54-62
20409738-2	2010	Its main gene product, human acid beta-galactosidase (beta-Gal) degrades two functionally important molecules, G(M1)-ganglioside and keratan sulfate in brain and connective tissues, respectively.	Keratan Sulfate	133-148	galactosidase beta 1	Homo sapiens	29-52
20409738-2	2010	Its main gene product, human acid beta-galactosidase (beta-Gal) degrades two functionally important molecules, G(M1)-ganglioside and keratan sulfate in brain and connective tissues, respectively.	Keratan Sulfate	133-148	galactosidase beta 1	Homo sapiens	54-62
20224429-6	2010	Selaginellin was shown to protect endothelial cells against homocysteine-induced senescence, as determined by senescence-associated beta-galactosidase activity, telomerase activity, and cell cycle distribution.	selaginellin S	0-12	galactosidase beta 1	Homo sapiens	132-150
20685473-1	2010	A novel enzyme reactor with co-immobilization of beta-galactosidase and glucose oxidase in calcium alginate fiber (CAF) and amine modified nanosized mesoporous silica (AMNMS) was prepared which incorporate the adsorption and catalysis of AMNMS with the cage effect of the polymer to increase catalytic activity and stability of immobilized enzyme.	Alginates	91-107	galactosidase beta 1	Homo sapiens	49-67
20685473-1	2010	A novel enzyme reactor with co-immobilization of beta-galactosidase and glucose oxidase in calcium alginate fiber (CAF) and amine modified nanosized mesoporous silica (AMNMS) was prepared which incorporate the adsorption and catalysis of AMNMS with the cage effect of the polymer to increase catalytic activity and stability of immobilized enzyme.	cafestol palmitate	115-118	galactosidase beta 1	Homo sapiens	49-67
20512434-0	2010	Nano-coating of beta-galactosidase onto the surface of lactose by using an ultrasound-assisted technique.	Lactose	55-62	galactosidase beta 1	Homo sapiens	16-34
20512434-1	2010	We nano-coated powdered lactose particles with the enzyme beta-galactosidase using an ultrasound-assisted technique.	Lactose	24-31	galactosidase beta 1	Homo sapiens	58-76
20512434-3	2010	The amount of surface-attached beta-galactosidase was measured through its enzymatic reaction product D-galactose using a standardized method.	Galactose	102-113	galactosidase beta 1	Homo sapiens	31-49
20512434-5	2010	Interestingly, lactose, which is a substrate for beta-galactosidase, did not undergo enzymatic degradation during processing and remained unchanged for at least 1 month.	Lactose	15-22	galactosidase beta 1	Homo sapiens	49-67
20216109-5	2010	Immunoabsorption studies showed that the cause of the interference was an endogenous antibody present in the patient"s plasma that recognized a unique epitope present on the antibody-enzyme (beta-galactosidase) conjugate used in the Siemens tacrolimus immunoassay but not on the antibody or beta-galactosidase alone.	Tacrolimus	241-251	galactosidase beta 1	Homo sapiens	191-209
20222868-6	2010	A subcytotoxic concentration of Adriamycin induced polyploid cells having the features of senescence, such as flattened and enlarged cell shape and activated beta-galactosidase activity.	Doxorubicin	32-42	galactosidase beta 1	Homo sapiens	158-176
19768521-4	2010	Thus we analyzed the D-amino acid contents of His-tag-purified beta-galactosidase and human urocortin, which were synthesized by Escherichia coli grown in controlled synthetic media.	d-amino acid	21-33	galactosidase beta 1	Homo sapiens	63-81
19768521-4	2010	Thus we analyzed the D-amino acid contents of His-tag-purified beta-galactosidase and human urocortin, which were synthesized by Escherichia coli grown in controlled synthetic media.	Histidine	46-49	galactosidase beta 1	Homo sapiens	63-81
20213119-0	2010	Ternary system of solution additives with arginine and salt for refolding of beta-galactosidase.	Arginine	42-50	galactosidase beta 1	Homo sapiens	77-95
20213119-0	2010	Ternary system of solution additives with arginine and salt for refolding of beta-galactosidase.	Salts	55-59	galactosidase beta 1	Homo sapiens	77-95
20213119-2	2010	This paper presents an investigation of the refolding of tetrameric beta-galactosidase (beta-gal) using Arg HCl and other salts.	Arginine	104-107	galactosidase beta 1	Homo sapiens	68-86
20213119-2	2010	This paper presents an investigation of the refolding of tetrameric beta-galactosidase (beta-gal) using Arg HCl and other salts.	Arginine	104-107	galactosidase beta 1	Homo sapiens	68-76
20213119-2	2010	This paper presents an investigation of the refolding of tetrameric beta-galactosidase (beta-gal) using Arg HCl and other salts.	Hydrochloric Acid	108-111	galactosidase beta 1	Homo sapiens	68-86
20213119-2	2010	This paper presents an investigation of the refolding of tetrameric beta-galactosidase (beta-gal) using Arg HCl and other salts.	Hydrochloric Acid	108-111	galactosidase beta 1	Homo sapiens	68-76
20213119-3	2010	In a binary system using only Arg HCl, the refolding yield of beta-gal increased with increasing concentration up to 0.2 M. However, the refolding yield sharply decreased above this concentration, reaching the level below the control yield of 5% at 0.5 M and near zero above 0.75 M, an observation unexpected from monomeric proteins.	Arginine	30-33	galactosidase beta 1	Homo sapiens	62-70
20213119-3	2010	In a binary system using only Arg HCl, the refolding yield of beta-gal increased with increasing concentration up to 0.2 M. However, the refolding yield sharply decreased above this concentration, reaching the level below the control yield of 5% at 0.5 M and near zero above 0.75 M, an observation unexpected from monomeric proteins.	Hydrochloric Acid	34-37	galactosidase beta 1	Homo sapiens	62-70
20501362-3	2010	The enzyme activities of beta-galactosidase were detected by a chromogenic substrate, chlorophenol red-beta-galactopyranoside (CPRG).	chlorophenol red-beta-galactopyranoside	86-125	galactosidase beta 1	Homo sapiens	25-43
20501362-3	2010	The enzyme activities of beta-galactosidase were detected by a chromogenic substrate, chlorophenol red-beta-galactopyranoside (CPRG).	Chlorophenol red galactopyranoside	127-131	galactosidase beta 1	Homo sapiens	25-43
20193693-0	2010	Gi-protein inhibitor, guanosine 5"-O-(2-thiodiphosphate), induces senescence-associated beta-galactosidase positive cell formation through CREB phosphorylation.	guanosine 5'-O-(2-thiodiphosphate)	22-55	galactosidase beta 1	Homo sapiens	88-106
20193693-1	2010	AIMS: We evaluated Gi-protein inhibitor, guanosine 5"-O-(2-thiodiphosphate)(GOT)-induced senescence-associated(SA)-beta-galactosidase(Gal) positive cell formation to determine if it occurred through phosphorylation of cyclic AMP-dependent response element binding protein (CREB).	guanosine 5'-O-(2-thiodiphosphate)	41-75	galactosidase beta 1	Homo sapiens	115-133
20216109-5	2010	Immunoabsorption studies showed that the cause of the interference was an endogenous antibody present in the patient"s plasma that recognized a unique epitope present on the antibody-enzyme (beta-galactosidase) conjugate used in the Siemens tacrolimus immunoassay but not on the antibody or beta-galactosidase alone.	Tacrolimus	241-251	galactosidase beta 1	Homo sapiens	291-309
19943044-0	2010	Galacto-oligosaccharide production using microbial beta-galactosidase: current state and perspectives.	galacto-oligosaccharide	0-23	galactosidase beta 1	Homo sapiens	51-69
19288068-5	2010	The effect of various preparation conditions on the activity of the immobilized beta-galactosidase, such as immobilizing time, amount of enzyme, and the concentration of glutaraldehyde, were investigated.	Glutaral	170-184	galactosidase beta 1	Homo sapiens	80-98
21386213-9	2010	beta-galactosidase activity was measured with the chromogenic substrates 5-bromo-4-chloro-3-indoyl-beta-d-galactopyranoside and isopropyl-beta-d-thiogalactopyranoside.	5-bromo-4-chloro-3-indoyl-beta-d-galactopyranoside	73-123	galactosidase beta 1	Homo sapiens	0-18
21386213-9	2010	beta-galactosidase activity was measured with the chromogenic substrates 5-bromo-4-chloro-3-indoyl-beta-d-galactopyranoside and isopropyl-beta-d-thiogalactopyranoside.	Isopropyl Thiogalactoside	128-166	galactosidase beta 1	Homo sapiens	0-18
21386213-10	2010	beta-galactosidase activity was positively correlated with malodor strength (organoleptic score, portable sulfide monitor score and VSC concentrations).	Sulfides	106-113	galactosidase beta 1	Homo sapiens	0-18
20338856-6	2010	Second, the method is applied to a biological cell system, employing as reporter a cytosolic fusion protein of beta-galactosidase with SNAP-tag labeled with tetramethylrhodamine.	tetramethylrhodamine	157-177	galactosidase beta 1	Homo sapiens	111-129
20027484-2	2010	Relative estrogenic potency was expressed by determining the beta-galactosidase activity (EC(50)) of the tuber extracts in relation to 17beta-estradiol.	Estradiol	135-151	galactosidase beta 1	Homo sapiens	61-79
21071905-6	2010	An increase in the beta-galactosidase activity in the umu-test observed with the migration solution of soup bowl was due not to polylactic acid, but to the polyurethane coating.	poly(lactide)	128-143	galactosidase beta 1	Homo sapiens	19-37
20410591-7	2010	Phloridzin induced beta-galactosidase activity in a yeast two-hybrid assay.	Phlorhizin	0-10	galactosidase beta 1	Homo sapiens	19-37
21071905-6	2010	An increase in the beta-galactosidase activity in the umu-test observed with the migration solution of soup bowl was due not to polylactic acid, but to the polyurethane coating.	Polyurethanes	156-168	galactosidase beta 1	Homo sapiens	19-37
19966440-8	2009	Structural comparisons of (II) with related disaccharides bound to a mutant beta-galactosidase reveal significant differences in hydroxymethyl conformation and in the degree of ring distortion of the betaGlcp residue.	Disaccharides	44-57	galactosidase beta 1	Homo sapiens	76-94
19836729-0	2009	Action of beta-galactosidase in medium on the Lemna minor (L.) callus polysaccharides.	Polysaccharides	70-85	galactosidase beta 1	Homo sapiens	10-28
19836729-1	2009	The callus culture of duckweed cultivated on medium containing different concentrations of beta-galactosidase was shown to produce the following polysaccharides: pectin lemnan LMC, intracellular AG1, and extracellular AG2 arabinogalactans.	Polysaccharides	145-160	galactosidase beta 1	Homo sapiens	91-109
19082762-0	2009	Lactose hydrolysis by beta-galactosidase covalently immobilized to thermally stable biopolymers.	Lactose	0-7	galactosidase beta 1	Homo sapiens	22-40
19082762-1	2009	Lactose has been hydrolyzed using covalently immobilized beta-galactosidase on thermally stable carrageenan coated with chitosan (hydrogel).	Lactose	0-7	galactosidase beta 1	Homo sapiens	57-75
19082762-1	2009	Lactose has been hydrolyzed using covalently immobilized beta-galactosidase on thermally stable carrageenan coated with chitosan (hydrogel).	Carrageenan	96-107	galactosidase beta 1	Homo sapiens	57-75
19082762-1	2009	Lactose has been hydrolyzed using covalently immobilized beta-galactosidase on thermally stable carrageenan coated with chitosan (hydrogel).	Chitosan	120-128	galactosidase beta 1	Homo sapiens	57-75
19698731-4	2009	The positive staining ratio of senescence-associated beta-galactosidase, number of cells in G1 phase, and cellular volume were all increased in WI-38 cells treated with l-leucine when the cellular population doubling (PD) number was 34, while the above phenotypes did not appear in control group until its PD number reached 40 (P &lt; 0.05).	Leucine	169-178	galactosidase beta 1	Homo sapiens	53-71
19467772-1	2009	Human colorectal adenocarcinoma C85 cells, treated with high dose methotrexate (1 microM; IC(50)=51 nM), undergo accelerated senescence, as the cells (i) are growth arrested at the G(1) and S phases of the cell cycle, (ii) are SA-beta-galactosidase-positive, (iii) show induced expression of p21(waf1/cip1) and decreased expression of p16(INK4a), and (iv) show DNA synthesis continued at the reduced level.	Methotrexate	66-78	galactosidase beta 1	Homo sapiens	230-248
20448926-4	2009	The beta-galactosidase label catalyzed the hydrolysis of 6,8-difluoro-4-methylumbelliferyl-beta-D-galactopyranoside (DiFMUG) and the resulting DiFMU(-) anion was detected by potentiometric microelectrodes with anion-exchanger membrane.	6,8-difluoro-4-methylumbelliferyl-beta-d-galactopyranoside	57-115	galactosidase beta 1	Homo sapiens	4-22
19564843-9	2009	Cultured HGECs treated with lysolecithin, the level of which is elevated in gallbladder bile of PBM, showed increased expression of p16(INK4A) and senescence-associated beta-galactosidase.	Lysophosphatidylcholines	28-40	galactosidase beta 1	Homo sapiens	169-187
19644515-4	2009	The human beta-galactosidase consists of three domains, such as, a TIM barrel fold domain, which functions as a catalytic domain, and two galactose-binding domain-like fold domains.	Galactose	138-147	galactosidase beta 1	Homo sapiens	10-28
20448926-4	2009	The beta-galactosidase label catalyzed the hydrolysis of 6,8-difluoro-4-methylumbelliferyl-beta-D-galactopyranoside (DiFMUG) and the resulting DiFMU(-) anion was detected by potentiometric microelectrodes with anion-exchanger membrane.	6,8-Difluoro-4-methyl-7-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one	117-123	galactosidase beta 1	Homo sapiens	4-22
20448926-4	2009	The beta-galactosidase label catalyzed the hydrolysis of 6,8-difluoro-4-methylumbelliferyl-beta-D-galactopyranoside (DiFMUG) and the resulting DiFMU(-) anion was detected by potentiometric microelectrodes with anion-exchanger membrane.	6,8-difluoro-4-methylumbelliferyl sulfate	117-122	galactosidase beta 1	Homo sapiens	4-22
19393360-6	2009	0.37 V vs. Ag/AgCl over a range of electrode materials within the working pH range of beta-galactosidase.	silver chloride	14-18	galactosidase beta 1	Homo sapiens	86-104
19472408-1	2009	Alterations in GLB1, the gene coding for acid beta-D-galactosidase (beta-Gal), can result in GM1 gangliosidosis (GM1), a neurodegenerative disorder, or in Morquio B disease (MBD), a phenotype with dysostosis multiplex and normal central nervous system (CNS) function.	G(M1) Ganglioside	93-96	galactosidase beta 1	Homo sapiens	15-19
19627195-6	2009	Exposure of young HDFs to H(2)O(2) induced G2/M cell cycle arrest, positive senescence-associated (SA) beta-galactosidase (beta-gal) staining, and elevated p53, p21, and p16 protein levels.	Hydrogen Peroxide	26-34	galactosidase beta 1	Homo sapiens	103-121
19627195-6	2009	Exposure of young HDFs to H(2)O(2) induced G2/M cell cycle arrest, positive senescence-associated (SA) beta-galactosidase (beta-gal) staining, and elevated p53, p21, and p16 protein levels.	Hydrogen Peroxide	26-34	galactosidase beta 1	Homo sapiens	103-111
19644418-1	2009	BACKGROUND: The aim was to study the effects of a single large dose of ethanol (approximately 2.0 g/kg of body weight, as 40% vodka) on the specific activities of alpha-mannosidase, alpha-fucosidase, beta-glucuronidase, and beta-galactosidase as well as on the total protein concentration in saliva in eight healthy young volunteers.	Ethanol	71-78	galactosidase beta 1	Homo sapiens	224-242
20021886-7	2009	SA-beta-galactosidase was detected by 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-Gal) staining method respectively in keratoconus and normal corneas.	5-bromo-4-chloro-3-indolyl beta-galactoside	38-89	galactosidase beta 1	Homo sapiens	3-21
20021886-7	2009	SA-beta-galactosidase was detected by 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-Gal) staining method respectively in keratoconus and normal corneas.	5-bromo-4-chloro-3-indolyl beta-galactoside	91-96	galactosidase beta 1	Homo sapiens	3-21
19407340-8	2009	Although increased MMP-1 levels are usually associated with angiogenesis in enabled proliferative EC, the exogenous addition of activated MMP-1 on lithium- arrested EC increases the number of EC positive for the senescent-associated-beta-galactosidase marker.	Lithium	147-154	galactosidase beta 1	Homo sapiens	233-251
19407340-9	2009	Conversely, down-regulation of MMP-1 expression by small interfering RNAs blunts the lithium-dependent increase in senescent-associated-beta-galactosidase positive cells.	Lithium	85-92	galactosidase beta 1	Homo sapiens	136-154
19286324-6	2009	HDFs exposed to pyocyanin (1-50 microM; 0.2-10.5 microg/ml) underwent growth arrest at all concentrations and developed morphological characteristics associated with cellular senescence, including expression of senescence-associated beta-galactosidase.	Pyocyanine	16-25	galactosidase beta 1	Homo sapiens	233-251
19531570-5	2009	Panc1 cells that survived high concentrations of gemcitabine had an increase in beta-galactosidase activity, a marker of senescence.	gemcitabine	49-60	galactosidase beta 1	Homo sapiens	80-98
19531570-6	2009	The inclusion of sphingomyelin with gemcitabine reduced beta-galactosidase activity, as compared with cells treated with gemcitabine alone.	Sphingomyelins	17-30	galactosidase beta 1	Homo sapiens	56-74
19531570-6	2009	The inclusion of sphingomyelin with gemcitabine reduced beta-galactosidase activity, as compared with cells treated with gemcitabine alone.	gemcitabine	36-47	galactosidase beta 1	Homo sapiens	56-74
19440623-1	2009	The conformational behaviour in aqueous solution of the EgadMe complex, a conditional gadolinium-based contrast agent sensitive to beta-galactosidase enzymatic activity, is investigated by means of ab initio calculations and classical molecular dynamics simulations.	Gadolinium	86-96	galactosidase beta 1	Homo sapiens	131-149
19111682-10	2009	Reliability of assays on DBS needs to be checked using a control enzyme such as beta-galactosidase.	dbs	25-28	galactosidase beta 1	Homo sapiens	80-98
19338287-4	2009	We used beta-galactosidase and its substrate, resorufin-beta-D-galactopyranoside, as the model system of the enzyme reaction.	resorufin galactopyranoside	46-80	galactosidase beta 1	Homo sapiens	8-26
19185564-1	2009	Although the primary response to Adriamycin (doxorubicin) in p53 mutant MDA-MB231 and p53 null MCF-7/E6 breast tumor cells is apoptotic cell death, the residual surviving population appears to be in a state of senescence, based on cell morphology, beta galactosidase staining, induction of p21(waf1/cip1) and down regulation of cdc2/cdk1.	Doxorubicin	33-43	galactosidase beta 1	Homo sapiens	248-266
19185564-1	2009	Although the primary response to Adriamycin (doxorubicin) in p53 mutant MDA-MB231 and p53 null MCF-7/E6 breast tumor cells is apoptotic cell death, the residual surviving population appears to be in a state of senescence, based on cell morphology, beta galactosidase staining, induction of p21(waf1/cip1) and down regulation of cdc2/cdk1.	Doxorubicin	45-56	galactosidase beta 1	Homo sapiens	248-266
19103143-0	2009	beta-Galactosidase activity assay using far-red-shifted fluorescent substrate DDAOG.	ddaog	78-83	galactosidase beta 1	Homo sapiens	0-18
19124464-4	2009	(i) In vitro and in situ, the inhibitory effect of GM3 on EGFR tyrosine kinase was much higher in A431 cells upon exposure of the GlcNAc termini of the N-glycans to glycosidase treatment (neuraminidase and beta-galactosidase) than in untreated A431 cells.	gm3	51-54	galactosidase beta 1	Homo sapiens	206-224
19147730-6	2009	RESULTS: AgNO(3) was a competitive inhibitor of beta-galactosidase [inhibition constant (K(i)) = 0.12 micromol/L] and completely inhibited beta-galactosidase activity when used at a concentration of 11 micromol/L.	agno	9-13	galactosidase beta 1	Homo sapiens	48-66
19147730-6	2009	RESULTS: AgNO(3) was a competitive inhibitor of beta-galactosidase [inhibition constant (K(i)) = 0.12 micromol/L] and completely inhibited beta-galactosidase activity when used at a concentration of 11 micromol/L.	agno	9-13	galactosidase beta 1	Homo sapiens	139-157
19243940-4	2009	By following this principle, phosphorylated and galactosylated analogues of 8-hydroxyquinolinylazo dyes were prepared and shown to act as reporters of enzymatic activity for alkaline phosphatase and beta-galactosidase respectively when using SERRS.	8-hydroxyquinolinylazo dyes	76-103	galactosidase beta 1	Homo sapiens	199-217
19243940-4	2009	By following this principle, phosphorylated and galactosylated analogues of 8-hydroxyquinolinylazo dyes were prepared and shown to act as reporters of enzymatic activity for alkaline phosphatase and beta-galactosidase respectively when using SERRS.	serrs	242-247	galactosidase beta 1	Homo sapiens	199-217
19103143-2	2009	One substrate, 9H-(1,3-dichloro-9,9-dimethylacridin-2-one-7-yl) beta-d-galactopyranoside (DDAOG), can be cleaved by beta-gal to produce 7-hydroxy-9H(I,3-dichloro-9,9-dimethylacridin-2-one) (DDAO).	9h-(1,3-dichloro-9,9-dimethylacridin-2-one-7-yl) beta-d-galactopyranoside	15-88	galactosidase beta 1	Homo sapiens	116-124
19103143-2	2009	One substrate, 9H-(1,3-dichloro-9,9-dimethylacridin-2-one-7-yl) beta-d-galactopyranoside (DDAOG), can be cleaved by beta-gal to produce 7-hydroxy-9H(I,3-dichloro-9,9-dimethylacridin-2-one) (DDAO).	ddaog	90-95	galactosidase beta 1	Homo sapiens	116-124
19103143-2	2009	One substrate, 9H-(1,3-dichloro-9,9-dimethylacridin-2-one-7-yl) beta-d-galactopyranoside (DDAOG), can be cleaved by beta-gal to produce 7-hydroxy-9H(I,3-dichloro-9,9-dimethylacridin-2-one) (DDAO).	7-hydroxy-9h(i,3-dichloro-9,9-dimethylacridin-2-one	136-187	galactosidase beta 1	Homo sapiens	116-124
19103143-2	2009	One substrate, 9H-(1,3-dichloro-9,9-dimethylacridin-2-one-7-yl) beta-d-galactopyranoside (DDAOG), can be cleaved by beta-gal to produce 7-hydroxy-9H(I,3-dichloro-9,9-dimethylacridin-2-one) (DDAO).	DDAO	90-94	galactosidase beta 1	Homo sapiens	116-124
19103143-11	2009	The beta-gal/DDAOG assay method should provide a fluorescent reporter assay system for the wide variety of beta-gal systems currently in use.	ddaog	13-18	galactosidase beta 1	Homo sapiens	107-115
19212656-7	2009	The response of the cell line to high glucose damaging stimulus was also evaluated, as senescence-associated beta-galactosidase activity and cell proliferation and a clear negative effect of high glucose on Bmi-HRP proliferation and senescence, in line with the characteristic response of wild-type cells, was observed.	Glucose	38-45	galactosidase beta 1	Homo sapiens	109-127
18571950-0	2009	The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient.	Galactose	24-33	galactosidase beta 1	Homo sapiens	73-91
18571950-7	2009	A significant increase (2,5 fold) in beta galactosidase activity occurred when galactose was added to the cultured fibroblasts of an adult patient.	Galactose	79-88	galactosidase beta 1	Homo sapiens	37-55
18571950-10	2009	The p.R442Q mutation was therefore selected as a potential target for the galactose chaperone; after the addition of galactose, COS-1 cells transfected with this mutation showed an increase in beta galactosidase activity from 6.9% to 12% of control values.	Galactose	74-83	galactosidase beta 1	Homo sapiens	193-211
18571950-10	2009	The p.R442Q mutation was therefore selected as a potential target for the galactose chaperone; after the addition of galactose, COS-1 cells transfected with this mutation showed an increase in beta galactosidase activity from 6.9% to 12% of control values.	Galactose	117-126	galactosidase beta 1	Homo sapiens	193-211
21383454-5	2009	Results showed that beta-galactosidase activity occurs in the outer layers and disappears following vancomycin addition, whereas VSC production occurs deeper within the biofilm and disappears following metronidazole application.	Vancomycin	100-110	galactosidase beta 1	Homo sapiens	20-38
18395435-1	2008	beta-Galactosidase is an hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides.	beta-galactoside	75-92	galactosidase beta 1	Homo sapiens	0-18
18339303-4	2008	Among them the positively charged Cys-containing peptide P10C demonstrated the most effective beta-galactosidase intracellular delivery.	Cysteine	34-37	galactosidase beta 1	Homo sapiens	94-112
18538675-4	2008	Supplementation of PUVA-treated fibroblasts with alpha-tocopherol (alpha-Toc), N-acetylcysteine (NAC), or alpha-lipoic acid (alpha-LA) abrogated the increased ROS generation and rescued fibroblasts from the ROS-dependent changes into the cellular senescence phenotype, such as cytoplasmic enlargement, enhanced expression of senescence-associated-beta-galactosidase and matrix-metalloproteinase-1, hallmarks of photoaging and intrinsic aging.	puva	19-23	galactosidase beta 1	Homo sapiens	347-365
18538675-4	2008	Supplementation of PUVA-treated fibroblasts with alpha-tocopherol (alpha-Toc), N-acetylcysteine (NAC), or alpha-lipoic acid (alpha-LA) abrogated the increased ROS generation and rescued fibroblasts from the ROS-dependent changes into the cellular senescence phenotype, such as cytoplasmic enlargement, enhanced expression of senescence-associated-beta-galactosidase and matrix-metalloproteinase-1, hallmarks of photoaging and intrinsic aging.	alpha-Tocopherol	49-65	galactosidase beta 1	Homo sapiens	347-365
18538675-4	2008	Supplementation of PUVA-treated fibroblasts with alpha-tocopherol (alpha-Toc), N-acetylcysteine (NAC), or alpha-lipoic acid (alpha-LA) abrogated the increased ROS generation and rescued fibroblasts from the ROS-dependent changes into the cellular senescence phenotype, such as cytoplasmic enlargement, enhanced expression of senescence-associated-beta-galactosidase and matrix-metalloproteinase-1, hallmarks of photoaging and intrinsic aging.	Acetylcysteine	79-95	galactosidase beta 1	Homo sapiens	347-365
18538675-4	2008	Supplementation of PUVA-treated fibroblasts with alpha-tocopherol (alpha-Toc), N-acetylcysteine (NAC), or alpha-lipoic acid (alpha-LA) abrogated the increased ROS generation and rescued fibroblasts from the ROS-dependent changes into the cellular senescence phenotype, such as cytoplasmic enlargement, enhanced expression of senescence-associated-beta-galactosidase and matrix-metalloproteinase-1, hallmarks of photoaging and intrinsic aging.	Acetylcysteine	97-100	galactosidase beta 1	Homo sapiens	347-365
18538675-4	2008	Supplementation of PUVA-treated fibroblasts with alpha-tocopherol (alpha-Toc), N-acetylcysteine (NAC), or alpha-lipoic acid (alpha-LA) abrogated the increased ROS generation and rescued fibroblasts from the ROS-dependent changes into the cellular senescence phenotype, such as cytoplasmic enlargement, enhanced expression of senescence-associated-beta-galactosidase and matrix-metalloproteinase-1, hallmarks of photoaging and intrinsic aging.	Thioctic Acid	106-123	galactosidase beta 1	Homo sapiens	347-365
18581104-3	2008	Furthermore, we successfully demonstrated an enzyme reaction in which the fluorogenic substrate TokyoGreen-beta-galactoside (TG-beta-gal) was hydrolyzed to the fluorescein derivative TokyoGreen (TG) and beta-galactose by the action of beta-galactosidase enzyme as a calalyst in a Y-shaped extended nanospace channel.	beta-galactoside	106-123	galactosidase beta 1	Homo sapiens	235-253
18581104-3	2008	Furthermore, we successfully demonstrated an enzyme reaction in which the fluorogenic substrate TokyoGreen-beta-galactoside (TG-beta-gal) was hydrolyzed to the fluorescein derivative TokyoGreen (TG) and beta-galactose by the action of beta-galactosidase enzyme as a calalyst in a Y-shaped extended nanospace channel.	tg-beta-gal	125-136	galactosidase beta 1	Homo sapiens	235-253
18581104-3	2008	Furthermore, we successfully demonstrated an enzyme reaction in which the fluorogenic substrate TokyoGreen-beta-galactoside (TG-beta-gal) was hydrolyzed to the fluorescein derivative TokyoGreen (TG) and beta-galactose by the action of beta-galactosidase enzyme as a calalyst in a Y-shaped extended nanospace channel.	Fluorescein	160-171	galactosidase beta 1	Homo sapiens	235-253
18441310-7	2008	RESULTS: The highest percentages of beta-gal expression in HCECs and MLPCs were achieved when the transfection reagent Lipofectamine 2000 was used.	Lipofectamine	119-137	galactosidase beta 1	Homo sapiens	36-44
19382700-1	2009	This was the first study to apply cyclodextrin glucanotransferases (CGTase, EC 2.4.1.19) produced by mesophilic, thermophilic, alkaliphilic, and halophilic bacilli as well as pullulanase, beta-amylase, beta-galactosidase, and beta-fructofuranosidase for transglycosylation of benzo[h]quinazolines.	Cyclodextrins	34-46	galactosidase beta 1	Homo sapiens	202-220
19028508-7	2009	In a bacterial based functional assay to rejoin a DNA break within the beta-galactosidase gene, RPMI 8226 demonstrated a 4-fold reduction in rejoining fidelity compared to U266, with OPM2 showing an intermediate capacity.	rpmi	96-100	galactosidase beta 1	Homo sapiens	71-89
19526476-1	2009	Involuntary association: Anionic beta-galactosidase enzymes associate with positively charged Au nanoparticles to produce reduced-charge conjugates, which assemble at oil-water interfaces to result in stable microcapsules (see picture).	Gold	94-96	galactosidase beta 1	Homo sapiens	33-51
19526476-1	2009	Involuntary association: Anionic beta-galactosidase enzymes associate with positively charged Au nanoparticles to produce reduced-charge conjugates, which assemble at oil-water interfaces to result in stable microcapsules (see picture).	Oils	167-170	galactosidase beta 1	Homo sapiens	33-51
19526476-1	2009	Involuntary association: Anionic beta-galactosidase enzymes associate with positively charged Au nanoparticles to produce reduced-charge conjugates, which assemble at oil-water interfaces to result in stable microcapsules (see picture).	Water	171-176	galactosidase beta 1	Homo sapiens	33-51
18538372-3	2009	We showed that after treatment of HCT116 cells with a low dose of doxorubicin most of them stopped proliferation as documented by SA-beta-galactosidase activity and the lack of Ki67 expression.	Doxorubicin	66-77	galactosidase beta 1	Homo sapiens	133-151
18481296-3	2008	Senescent cells were characterized using the senescence-associated-beta-galactosidase marker (SA-beta-Gal marker) by staining with chromogenic substrate (X-Gal) to produce blue coloration of SA-beta-Gal-positive cells and microscopy analysis.	beta-D-galactose	97-105	galactosidase beta 1	Homo sapiens	67-85
18957176-3	2008	Reactive oxygen species generation, lipid peroxidation, and senescence-associated beta-galactosidase activity were elevated in TIG-1 cells under SIPS induced by H2O2.	Hydrogen Peroxide	161-165	galactosidase beta 1	Homo sapiens	82-100
18830969-4	2008	Plasmid pCMVbeta, expressing beta-galactosidase, was encapsulated with cationic liposome, and then the histidine-tagged preS domain of hepatitis B virus was coated on the surface of liposome/DNA to form preS/liposome/ DNA VLP.	Histidine	103-112	galactosidase beta 1	Homo sapiens	29-47
18556572-3	2008	METHODS AND RESULTS: Prematurely senescent human umbilical vein endothelial cells (HUVECs) were induced by treatment with hydrogen peroxide (H(2)O(2)) as judged by senescence-associated beta-galactosidase assay (SA-betagal), cell morphological appearance, and plasminogen activator inhibitor-1 (PAI-1) expression.	Hydrogen Peroxide	122-139	galactosidase beta 1	Homo sapiens	186-204
18581104-3	2008	Furthermore, we successfully demonstrated an enzyme reaction in which the fluorogenic substrate TokyoGreen-beta-galactoside (TG-beta-gal) was hydrolyzed to the fluorescein derivative TokyoGreen (TG) and beta-galactose by the action of beta-galactosidase enzyme as a calalyst in a Y-shaped extended nanospace channel.	Thioguanine	125-127	galactosidase beta 1	Homo sapiens	235-253
18581104-3	2008	Furthermore, we successfully demonstrated an enzyme reaction in which the fluorogenic substrate TokyoGreen-beta-galactoside (TG-beta-gal) was hydrolyzed to the fluorescein derivative TokyoGreen (TG) and beta-galactose by the action of beta-galactosidase enzyme as a calalyst in a Y-shaped extended nanospace channel.	beta-D-galactose	203-217	galactosidase beta 1	Homo sapiens	235-253
18498442-9	2008	Furthermore, treatment with lithium decreased beta-gal complementation of both T4 and C3 indicating that the interaction of these proteins was attenuated.	Lithium	28-35	galactosidase beta 1	Homo sapiens	46-54
18395435-1	2008	beta-Galactosidase is an hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides.	Monosaccharides	98-113	galactosidase beta 1	Homo sapiens	0-18
18837381-0	2008	[Recent progress on galacto-oligosaccharides synthesis by microbial beta-galactosidase--a review].	galacto-oligosaccharides	20-44	galactosidase beta 1	Homo sapiens	68-86
18439774-0	2008	Concanavalin A layered calcium alginate-starch beads immobilized beta galactosidase as a therapeutic agent for lactose intolerant patients.	Alginates	23-39	galactosidase beta 1	Homo sapiens	65-83
18439774-0	2008	Concanavalin A layered calcium alginate-starch beads immobilized beta galactosidase as a therapeutic agent for lactose intolerant patients.	Starch	40-46	galactosidase beta 1	Homo sapiens	65-83
18439774-1	2008	A novel therapeutic agent in the form of beta galactosidase immobilized on the surface of concanavalin A layered calcium alginate-starch beads has been developed.	Alginates	113-129	galactosidase beta 1	Homo sapiens	41-59
18439774-1	2008	A novel therapeutic agent in the form of beta galactosidase immobilized on the surface of concanavalin A layered calcium alginate-starch beads has been developed.	Starch	130-136	galactosidase beta 1	Homo sapiens	41-59
19123989-0	2008	Radiosynthesis and evaluation of 5-[125I]iodoindol-3-yl-beta-D-galactopyranoside as a beta-galactosidase imaging radioligand.	5-(125I)iodoindol-3-yl-beta-D-galactopyranoside	33-80	galactosidase beta 1	Homo sapiens	86-104
19123989-3	2008	[125I]IBDG was evaluated as a substrate using beta-galactosidase-expressing (D54L) and nonexpressing (D54) human glioma cell lines.	ibdg	6-10	galactosidase beta 1	Homo sapiens	46-64
19123989-7	2008	Based on dynamic SPECT imaging and blood metabolite analysis, we conclude that although [125I]IBDG is an efficient in vivo substrate for beta-galactosidase, its rapid renal clearance hampers its intratumoral availability on systemic administration.	ibdg	94-98	galactosidase beta 1	Homo sapiens	137-155
18837381-2	2008	Commercial GOS are synthesized from lactose using the transglycosylation activity of beta-galactosidase from microorganisms.	Lactose	36-43	galactosidase beta 1	Homo sapiens	85-103
18226607-4	2008	After exposure to 8 mM tert-butylhydroperoxide (tert-BHP) for 1 h daily for 5 days, the cells showed four well-known senescence biomarkers: hypertrophy, senescence-associated beta-galactosidase activity, growth arrest, and cell cycle arrest in G1.	tert-Butylhydroperoxide	23-46	galactosidase beta 1	Homo sapiens	175-193
20641353-23	2004	The presence of beta-gal allows for quantitative measurement of transduction efficiency of Baavi-bUSPIO in vitro and/or histological evaluation of Baavi-bUSPIO in targeted tissues ex vivo.	baavi-buspio	91-103	galactosidase beta 1	Homo sapiens	16-24
18353697-4	2008	The putative signal sequence consists of amino acids 1-24 of the beta-galactosidase precursor protein, which contains seven potential N-linked glycosylation sites, as in the human protein.	Nitrogen	134-135	galactosidase beta 1	Homo sapiens	65-83
18391207-6	2008	IMR-90 fibroblast populations cultured in magnesium-deficient conditions had increased senescence-associated beta-galactosidase activity and increased p16(INK4a) and p21(WAF1) protein expression compared with cultures from standard media conditions.	Magnesium	42-51	galactosidase beta 1	Homo sapiens	109-127
18392450-0	2008	Transient high-level expression of beta-galactosidase after transfection of fibroblasts from GM1 gangliosidosis patients with plasmid DNA.	G(M1) Ganglioside	93-96	galactosidase beta 1	Homo sapiens	35-53
18392450-1	2008	GM1 gangliosidosis is an autosomal recessive disorder caused by the deficiency of lysosomal acid hydrolase beta-galactosidase (beta-Gal).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	107-125
18392450-1	2008	GM1 gangliosidosis is an autosomal recessive disorder caused by the deficiency of lysosomal acid hydrolase beta-galactosidase (beta-Gal).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	127-135
18226607-4	2008	After exposure to 8 mM tert-butylhydroperoxide (tert-BHP) for 1 h daily for 5 days, the cells showed four well-known senescence biomarkers: hypertrophy, senescence-associated beta-galactosidase activity, growth arrest, and cell cycle arrest in G1.	tert-Butylhydroperoxide	48-56	galactosidase beta 1	Homo sapiens	175-193
18293901-0	2008	Novel dense CO2 technique for beta-galactosidase immobilization in polystyrene microchannels.	Carbon Dioxide	12-15	galactosidase beta 1	Homo sapiens	30-48
18385095-12	2008	Hydrogen peroxide caused a large (&gt;90%) dose-dependent increase in beta-galactosidase-positive cells, whereas in the untreated control only single cells expressed this enzyme (&lt;5%).	Hydrogen Peroxide	0-17	galactosidase beta 1	Homo sapiens	70-88
18293901-0	2008	Novel dense CO2 technique for beta-galactosidase immobilization in polystyrene microchannels.	Polystyrenes	67-78	galactosidase beta 1	Homo sapiens	30-48
18293901-3	2008	Carbon dioxide at 40 degrees C and between 4.48 and 6.89 MPa was used to immobilize the biologically active molecule, beta-galactosidase (beta-gal), on the surface of polystyrene microchannels.	Carbon Dioxide	0-14	galactosidase beta 1	Homo sapiens	118-136
18293901-3	2008	Carbon dioxide at 40 degrees C and between 4.48 and 6.89 MPa was used to immobilize the biologically active molecule, beta-galactosidase (beta-gal), on the surface of polystyrene microchannels.	Carbon Dioxide	0-14	galactosidase beta 1	Homo sapiens	118-126
18293901-3	2008	Carbon dioxide at 40 degrees C and between 4.48 and 6.89 MPa was used to immobilize the biologically active molecule, beta-galactosidase (beta-gal), on the surface of polystyrene microchannels.	Polystyrenes	167-178	galactosidase beta 1	Homo sapiens	118-136
18293901-3	2008	Carbon dioxide at 40 degrees C and between 4.48 and 6.89 MPa was used to immobilize the biologically active molecule, beta-galactosidase (beta-gal), on the surface of polystyrene microchannels.	Polystyrenes	167-178	galactosidase beta 1	Homo sapiens	118-126
18034356-5	2008	By germinating the lines in a medium containing the nitric oxide (NO) donor, sodium nitroprusside (SNP), it was demonstrated that both GLB1 and GLB2 promote bolting by antagonizing the effect of NO, suggesting that non-symbiotic plant hemoglobin controls bolting by scavenging the floral transition signal molecule, NO.	Nitric Oxide	52-64	galactosidase beta 1	Homo sapiens	135-139
18034356-5	2008	By germinating the lines in a medium containing the nitric oxide (NO) donor, sodium nitroprusside (SNP), it was demonstrated that both GLB1 and GLB2 promote bolting by antagonizing the effect of NO, suggesting that non-symbiotic plant hemoglobin controls bolting by scavenging the floral transition signal molecule, NO.	Nitroprusside	77-97	galactosidase beta 1	Homo sapiens	135-139
18341246-0	2008	Kinetic analysis of urea-inactivation of beta-galactosidase in the presence of galactose.	Urea	20-24	galactosidase beta 1	Homo sapiens	41-59
18341246-0	2008	Kinetic analysis of urea-inactivation of beta-galactosidase in the presence of galactose.	Galactose	79-88	galactosidase beta 1	Homo sapiens	41-59
18341246-1	2008	The effect of galactose on the inactivation of purified beta-galactosidase from the black bean, Kestingiella geocarpa, in 5 M urea at 50 degrees C and at pH 4.5, was determined.	Galactose	14-23	galactosidase beta 1	Homo sapiens	56-74
18341246-1	2008	The effect of galactose on the inactivation of purified beta-galactosidase from the black bean, Kestingiella geocarpa, in 5 M urea at 50 degrees C and at pH 4.5, was determined.	Urea	126-130	galactosidase beta 1	Homo sapiens	56-74
17928415-5	2008	Based on the above findings of lysosomal permeabilization, we hypothesized that the reduced activity of senescence-associated beta-galactosidase could be responsible for the cellular accumulation of gangliosides, previously shown to induce cell senescence.	Gangliosides	199-211	galactosidase beta 1	Homo sapiens	126-144
18389896-9	2008	At passages 8-12, fibroblasts exposed to stavudine or zidovudine but not abacavir, didanosine, lamivudine and tenofovir were senescent, on the basis of p16(INK4) and p21(WAF-1) protein expression, cell morphology and senescence-associated-beta-galactosidase activity.	Stavudine	41-50	galactosidase beta 1	Homo sapiens	239-257
18389896-9	2008	At passages 8-12, fibroblasts exposed to stavudine or zidovudine but not abacavir, didanosine, lamivudine and tenofovir were senescent, on the basis of p16(INK4) and p21(WAF-1) protein expression, cell morphology and senescence-associated-beta-galactosidase activity.	Zidovudine	54-64	galactosidase beta 1	Homo sapiens	239-257
21591161-3	2008	The substrate for the continuous assay of beta-galactosidase is the chromogenic 2-nitrophenyl-beta-D-galactopyranoside that produces 2-NP.	2-nitrophenylgalactoside	80-118	galactosidase beta 1	Homo sapiens	42-60
21591161-3	2008	The substrate for the continuous assay of beta-galactosidase is the chromogenic 2-nitrophenyl-beta-D-galactopyranoside that produces 2-NP.	2-nitrophenol	133-137	galactosidase beta 1	Homo sapiens	42-60
17992679-0	2008	A Gd3+-based magnetic resonance imaging contrast agent sensitive to beta-galactosidase activity utilizing a receptor-induced magnetization enhancement (RIME) phenomenon.	ganglioside, GD3	2-6	galactosidase beta 1	Homo sapiens	68-86
17992679-6	2008	Here we describe the design and synthesis of a novel beta-galactosidase-activated MRI contrast agent, the Gd(3+) complex [Gd-5], by using the RIME approach.	ganglioside, GD3	106-112	galactosidase beta 1	Homo sapiens	53-71
17992679-6	2008	Here we describe the design and synthesis of a novel beta-galactosidase-activated MRI contrast agent, the Gd(3+) complex [Gd-5], by using the RIME approach.	Gadolinium	106-108	galactosidase beta 1	Homo sapiens	53-71
17992679-6	2008	Here we describe the design and synthesis of a novel beta-galactosidase-activated MRI contrast agent, the Gd(3+) complex [Gd-5], by using the RIME approach.	rime	142-146	galactosidase beta 1	Homo sapiens	53-71
17992679-8	2008	This newly synthesized compound exhibited a 57% increase in the r(1) relaxivity in phosphate-buffered saline (PBS) with 4.5% w/v human serum albumin (HSA) in the presence of beta-galactosidase.	Phosphate-Buffered Saline	83-108	galactosidase beta 1	Homo sapiens	174-192
18690875-8	2008	Indeed, we have shown that AZT-treated K562 cells exhibited a reduced sialylation of proteins and lipids, and a strong inhibition of alpha,(2--&gt;8) sialyltransferase activity while beta,(1--&gt;4)galactosyltransferase and beta-galactosidase activities were significantly increased.	Zidovudine	27-30	galactosidase beta 1	Homo sapiens	224-242
18047931-11	2008	The cell-stimulating effects of N- and R-THP could be abolished by digesting them with CHO-degrading enzymes, beta-galactosidase and neuraminidase.	n- and r-thp	32-44	galactosidase beta 1	Homo sapiens	110-128
17943217-3	2007	Preliminary biological data indicate that two of these novel amino pyrrolidines are moderate inhibitors of beta-galactosidase.	amino pyrrolidines	61-79	galactosidase beta 1	Homo sapiens	107-125
17994547-2	2007	In this study, we performed oral administration of a chaperone compound N-octyl-4-epi-beta-valienamine to G(M1)-gangliosidosis model mice expressing R201C mutant human beta-galactosidase.	N-octyl-beta-valienamine	72-102	galactosidase beta 1	Homo sapiens	168-186
17935289-7	2007	The signal intensity of the MR image for [Gd(DOTA-FPG)(H 2O)] in the presence of human serum albumin and beta-galactosidase (2670 +/- 210) is significantly higher than that of [Gd(DOTA-FPG)(H 2O)] in the sodium phosphate buffer solution (1490 +/- 160).	sodium phosphate	204-220	galactosidase beta 1	Homo sapiens	105-123
17854772-2	2007	The binding was inhibited by anti-band 3 serum and prevented by pretreatment of erythrocytes with a polylactosamine-cleaving enzyme endo-beta-galactosidase, indicating that polylactosaminyl sugar chains of band 3 are recognized by macrophages.	polylactosamine	100-115	galactosidase beta 1	Homo sapiens	137-155
17854772-2	2007	The binding was inhibited by anti-band 3 serum and prevented by pretreatment of erythrocytes with a polylactosamine-cleaving enzyme endo-beta-galactosidase, indicating that polylactosaminyl sugar chains of band 3 are recognized by macrophages.	Sugars	190-195	galactosidase beta 1	Homo sapiens	137-155
17620292-3	2007	Treatment with apigenin (0, 20, 40, 60, and 80 microM) for 48 h resulted in reduction in the cell number (P &lt; 0.05) concurrent with flow cytometry results showing a dose-dependent accumulation of cells in the G2/M phase in both HT29-APC and HT29-GAL cells without ZnCl(2) treatment.	Apigenin	15-23	galactosidase beta 1	Homo sapiens	249-252
17944861-2	2007	We determined the distribution of beta-galactosidase (beta-gal), phospho-beta-galactosidase (P-betagal) and phospho-beta-glucosidase (P-beta-glc) activities in species of lactic acid bacteria (LAB) isolated from human faeces to select strains for potential use in fermented dairy products, e.g. yogurt.	Lactic Acid	171-182	galactosidase beta 1	Homo sapiens	34-52
17944861-2	2007	We determined the distribution of beta-galactosidase (beta-gal), phospho-beta-galactosidase (P-betagal) and phospho-beta-glucosidase (P-beta-glc) activities in species of lactic acid bacteria (LAB) isolated from human faeces to select strains for potential use in fermented dairy products, e.g. yogurt.	Lactic Acid	171-182	galactosidase beta 1	Homo sapiens	34-42
17661304-0	2007	Thioglycoligase-based assembly of thiodisaccharides: screening as beta-galactosidase inhibitors.	thiodisaccharides	34-51	galactosidase beta 1	Homo sapiens	66-84
17924880-13	2007	The expression of senescence-associated-beta-galactosidase was only significantly elevated in cells chronically exposed to 5 microM HP.	Hydrogen Peroxide	132-134	galactosidase beta 1	Homo sapiens	40-58
17404806-0	2007	Significance of local mobility in aggregation of beta-galactosidase lyophilized with trehalose, sucrose or stachyose.	Trehalose	85-94	galactosidase beta 1	Homo sapiens	49-67
17765639-3	2007	DDMC has been confirmed as having a high protection facility for DNase by DNase degradation test.Transfection activity was determined using the beta-galactosidase assay, and a higher value of 16 times or more was confirmed for the DDMC samples in comparison with one of the starting DEAE-dextran hydrochloride samples.	2',3'-dideoxy-5-methylcytidine	0-4	galactosidase beta 1	Homo sapiens	144-162
17404806-4	2007	Furthermore, the T(1rho) of the beta-GA carbonyl carbon was measured by (13)C solid-state NMR, and T(g) was measured by modulated temperature differential scanning calorimetry.	Carbon	40-46	galactosidase beta 1	Homo sapiens	32-39
17404806-0	2007	Significance of local mobility in aggregation of beta-galactosidase lyophilized with trehalose, sucrose or stachyose.	Sucrose	96-103	galactosidase beta 1	Homo sapiens	49-67
17404806-7	2007	Although the T(g) rank order of beta-GA formulations was sucrose &lt; trehalose &lt; stachyose, the rank order of beta-GA aggregation rate at temperatures below and above T(g) was also sucrose &lt; trehalose &lt; stachyose, thus suggesting that beta-GA aggregation rate is not related to (T-T(g)).	Sucrose	57-64	galactosidase beta 1	Homo sapiens	32-39
17404806-8	2007	The local mobility of beta-GA, as determined by the T(1rho) of the beta-GA carbonyl carbon, was more markedly decreased by the addition of sucrose than by the addition of stachyose.	Carbon	75-81	galactosidase beta 1	Homo sapiens	22-29
17404806-0	2007	Significance of local mobility in aggregation of beta-galactosidase lyophilized with trehalose, sucrose or stachyose.	stachyose	107-116	galactosidase beta 1	Homo sapiens	49-67
17404806-8	2007	The local mobility of beta-GA, as determined by the T(1rho) of the beta-GA carbonyl carbon, was more markedly decreased by the addition of sucrose than by the addition of stachyose.	Carbon	75-81	galactosidase beta 1	Homo sapiens	67-74
17404806-2	2007	MATERIALS AND METHODS: The storage stability of beta-GA lyophilized with sucrose, trehalose or stachyose was investigated at 12% relative humidity and various temperatures (40-90 degrees C).	Sucrose	73-80	galactosidase beta 1	Homo sapiens	48-55
17404806-8	2007	The local mobility of beta-GA, as determined by the T(1rho) of the beta-GA carbonyl carbon, was more markedly decreased by the addition of sucrose than by the addition of stachyose.	Sucrose	139-146	galactosidase beta 1	Homo sapiens	22-29
17404806-8	2007	The local mobility of beta-GA, as determined by the T(1rho) of the beta-GA carbonyl carbon, was more markedly decreased by the addition of sucrose than by the addition of stachyose.	Sucrose	139-146	galactosidase beta 1	Homo sapiens	67-74
17636988-7	2007	To enable digestion of complex and hybrid type N-glycans, a number of exoglycosidases (beta-galactosidase, neuraminidase and N-acetyl-beta-glucosaminidase) are also included.	n-glycans	47-56	galactosidase beta 1	Homo sapiens	87-105
17661814-7	2007	He was a heterozygous compound with p.Arg595Trp in trans with one of the disease-causing mutations identified in his daughter; in leukocytes and plasma he showed lower beta-galactosidase activity than that observed in GM1 gangliosidosis carriers.	G(M1) Ganglioside	218-221	galactosidase beta 1	Homo sapiens	168-186
17627580-3	2007	Among them, N-octyl-4-epi-beta-valienamine as a lysosomal beta-galactosidase inhibitor is currently undergoing a new molecular therapeutic trial (chemical chaperone therapy) for control of the human beta-galactosidase deficiency disorder, G(M1)-gangliosidosis.	N-octyl-beta-valienamine	12-42	galactosidase beta 1	Homo sapiens	58-76
17512738-3	2007	The longitudinal proton relaxivities of the neutral [Gd-(Gal-PA-DO3A-NH2)] and [Gd-(Gal-DO3A)] complexes were increased by 28% and 37% in the presence of beta-galactosidase, respectively.	Gadolinium	53-55	galactosidase beta 1	Homo sapiens	154-172
17512738-3	2007	The longitudinal proton relaxivities of the neutral [Gd-(Gal-PA-DO3A-NH2)] and [Gd-(Gal-DO3A)] complexes were increased by 28% and 37% in the presence of beta-galactosidase, respectively.	gal-pa-do3a-nh2	57-72	galactosidase beta 1	Homo sapiens	154-172
17512738-3	2007	The longitudinal proton relaxivities of the neutral [Gd-(Gal-PA-DO3A-NH2)] and [Gd-(Gal-DO3A)] complexes were increased by 28% and 37% in the presence of beta-galactosidase, respectively.	Gadolinium	53-56	galactosidase beta 1	Homo sapiens	154-172
17512738-3	2007	The longitudinal proton relaxivities of the neutral [Gd-(Gal-PA-DO3A-NH2)] and [Gd-(Gal-DO3A)] complexes were increased by 28% and 37% in the presence of beta-galactosidase, respectively.	gal-do3a	84-92	galactosidase beta 1	Homo sapiens	154-172
17711777-4	2007	A375 cells expressing beta-galactosidase were similarly exposed to hypoxia, with activity of the reporter monitored by cleavage of the fluorescent substrate 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one)-beta-galactoside (DDAOG).	7-hydroxy-9h-(1,3-dichloro-9,9-dimethylacridin-2-one)-beta-galactoside	157-227	galactosidase beta 1	Homo sapiens	22-40
17307293-8	2007	This methodology was first tested to model complexities encountered in inhibition by imidazole of beta-galactosidase, an enzyme that obeys Michaelis-Menten kinetics.	imidazole	85-94	galactosidase beta 1	Homo sapiens	98-116
17785060-5	2007	RESULTS: The HSFs of the control and EGCG groups only showed a few beta-GAL positive cells, and the beta-GAL positive cell ratios of the other 4 groups were higher and could be arranged from low to high according to the sequence: UVB group (43% +/- 4%) &lt; UVA group (54% +/- 4%) &lt; EGCG + UVB group (64% +/- 5%) &lt; EGCG + UVA group (75% +/- 5%).	epigallocatechin gallate	37-41	galactosidase beta 1	Homo sapiens	67-75
17352500-1	2007	This work describes the immobilization of beta-galactosidase onto polyelectrolyte multilayer assemblies of the polyanion poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) and the polycation poly(ethylenimine) (PEI) constructed by electrostatic self-assembly (ESA).	polyanions	111-120	galactosidase beta 1	Homo sapiens	42-60
17418177-4	2007	The beta-gal specific landscape phage 1G40 has been immobilized on the gold surface of SPR SPREETA sensor chip through physical adsorption [V. Nanduri, A.M. Samoylova, V.Petrenko, V. Vodyanoy and A.L.Simonian, Comparison of optical and acoustic wave phage biosensors, 206th Meeting of The Electrochemical Society, Honolulu, Hawaii, October 3-8, (2004)].	spreeta	91-98	galactosidase beta 1	Homo sapiens	4-12
17307730-4	2007	Furthermore, reducing Nampt activity with the antagonist FK866 induced premature senescence in SMCs, assessed by serial quantification of the proportion of cells with senescence-associated beta-galactosidase activity.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	57-62	galactosidase beta 1	Homo sapiens	189-207
17352500-1	2007	This work describes the immobilization of beta-galactosidase onto polyelectrolyte multilayer assemblies of the polyanion poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) and the polycation poly(ethylenimine) (PEI) constructed by electrostatic self-assembly (ESA).	poly(1-(4-(3-carboxy-4 hydroxyphenylazo)benzene sulfonamido)-1,2-ethanediyl, sodium salt)	121-209	galactosidase beta 1	Homo sapiens	42-60
17352500-1	2007	This work describes the immobilization of beta-galactosidase onto polyelectrolyte multilayer assemblies of the polyanion poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) and the polycation poly(ethylenimine) (PEI) constructed by electrostatic self-assembly (ESA).	poly(1-(4-(3-carboxy-4 hydroxyphenylazo)benzene sulfonamido)-1,2-ethanediyl, sodium salt)	211-215	galactosidase beta 1	Homo sapiens	42-60
17352500-1	2007	This work describes the immobilization of beta-galactosidase onto polyelectrolyte multilayer assemblies of the polyanion poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) and the polycation poly(ethylenimine) (PEI) constructed by electrostatic self-assembly (ESA).	Polyethyleneimine	236-254	galactosidase beta 1	Homo sapiens	42-60
17662641-3	2007	We show that bleomycin-treated A549 cells exhibit: senescence-like cell morphology; a senescence-associated increase in SA-beta-galactosidase activity; cell cycle arrest; and upregulation of p53 and p21.	Bleomycin	13-22	galactosidase beta 1	Homo sapiens	123-141
17624240-4	2007	Results show that in TBL during spontaneous apoptosis, there is a significant increase in the activity of beta-hexosaminidases, alpha-mannosidase, beta-mannosidase and beta-galactosidase.	thalicarpine	21-24	galactosidase beta 1	Homo sapiens	168-186
17234690-6	2007	FS-induced NO(i) production was decreased in myocytes infected (100 multiplicity of viral infection (MOI); 24 h) with a replication-deficient adenovirus expressing a dominant-negative mutant of protein kinase B (Akt) compared with cells infected with a control adenovirus expressing beta-galactosidase.	phenylalanylserine	0-2	galactosidase beta 1	Homo sapiens	283-301
17300128-2	2007	beta-D-Galactopyranoside, the substrate of beta-galactosidase, was conjugated to 2SBPO through a para-substituted benzyloxycarbonyl group and a glycine residue, which serve as a self-immolative spacer and as a molecular blocker to mask the optical signal of 2SBPO, respectively.	beta-D-galactopyranoside	0-24	galactosidase beta 1	Homo sapiens	43-61
17300128-2	2007	beta-D-Galactopyranoside, the substrate of beta-galactosidase, was conjugated to 2SBPO through a para-substituted benzyloxycarbonyl group and a glycine residue, which serve as a self-immolative spacer and as a molecular blocker to mask the optical signal of 2SBPO, respectively.	2sbpo	81-86	galactosidase beta 1	Homo sapiens	43-61
17300128-2	2007	beta-D-Galactopyranoside, the substrate of beta-galactosidase, was conjugated to 2SBPO through a para-substituted benzyloxycarbonyl group and a glycine residue, which serve as a self-immolative spacer and as a molecular blocker to mask the optical signal of 2SBPO, respectively.	Glycine	144-151	galactosidase beta 1	Homo sapiens	43-61
17300128-2	2007	beta-D-Galactopyranoside, the substrate of beta-galactosidase, was conjugated to 2SBPO through a para-substituted benzyloxycarbonyl group and a glycine residue, which serve as a self-immolative spacer and as a molecular blocker to mask the optical signal of 2SBPO, respectively.	2sbpo	258-263	galactosidase beta 1	Homo sapiens	43-61
17052245-0	2007	Optimization of transfection mediated by calcium phosphate for plasmid rAAV-LacZ (recombinant adeno-associated virus-beta-galactosidase reporter gene) production in suspension-cultured HEK-293 (human embryonic kidney 293) cells.	calcium phosphate	41-58	galactosidase beta 1	Homo sapiens	117-135
17052245-3	2007	An optimal suspension-culture transfection procedure was developed for rAAV-LacZ production in suspended HEK-293 cells mediated by calcium phosphate (lacZ, a reporter gene, codes for beta-galactosidase).	raav-lacz	71-80	galactosidase beta 1	Homo sapiens	183-201
17221873-0	2007	GM1 gangliosidosis: molecular analysis of nine patients and development of an RT-PCR assay for GLB1 gene expression profiling.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	95-99
17221873-5	2007	We also report the characterisation of GLB1 gene mutations in nine GM1 gangliosidosis patients in order to correlate the genetic lesions with mRNA levels and phenotypes.	G(M1) Ganglioside	67-70	galactosidase beta 1	Homo sapiens	39-43
17662641-4	2007	As predicted, we find that caveolin-1 amount increases in response to bleomycin-treatment and that modulation of caveolin-1 affects p21 and p53 levels, cell cycling, and senescence (SA-beta-galactosidase activity).	Bleomycin	70-79	galactosidase beta 1	Homo sapiens	185-203
17662641-5	2007	Interestingly, senescence-associated cell cycle arrest via p53 and p21 and SA-beta-galactosidase activity is reduced in young A549 cells when short hairpin RNA specific for caveolin-1 was applied before bleomycin-treatment.	Bleomycin	203-212	galactosidase beta 1	Homo sapiens	78-96
17373452-4	2007	The principle of the method is the hydrolysis of lactose to D-glucose and D-galactose by beta-galactosidase, followed by the oxidation of beta-D-galactose by nicotinamide adenine dinucleotide (NAD+) in the presence of beta-galactose dehydrogenase.	Lactose	49-56	galactosidase beta 1	Homo sapiens	89-107
17373452-4	2007	The principle of the method is the hydrolysis of lactose to D-glucose and D-galactose by beta-galactosidase, followed by the oxidation of beta-D-galactose by nicotinamide adenine dinucleotide (NAD+) in the presence of beta-galactose dehydrogenase.	Glucose	60-69	galactosidase beta 1	Homo sapiens	89-107
17373452-4	2007	The principle of the method is the hydrolysis of lactose to D-glucose and D-galactose by beta-galactosidase, followed by the oxidation of beta-D-galactose by nicotinamide adenine dinucleotide (NAD+) in the presence of beta-galactose dehydrogenase.	Galactose	74-85	galactosidase beta 1	Homo sapiens	89-107
17995883-2	2007	Beta-galactosidase (lactase) was covalently attached to surface-functionalized low-density polyethylene films.	Polyethylene	91-103	galactosidase beta 1	Homo sapiens	0-18
17634571-4	2007	Several years ago, we described a biomarker associated with the senescent phenotype, a senescence associated beta-galactosidase (SA-beta-gal), which is detected by histochemical staining of cells using the artificial substrate X-gal.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	129-140	galactosidase beta 1	Homo sapiens	109-127
17335496-3	2007	* An arginine-rich intracellular delivery (AID) peptide could rapidly deliver fluorescent proteins or beta-galactosidase enzyme into plant and animal cells in a noncovalent fashion.	Arginine	5-13	galactosidase beta 1	Homo sapiens	102-120
17115280-4	2006	(2) Multi-antennary complex-type N-linked OS isolated from fetuin, treated by sialidase followed by beta-galactosidase, having three or four GlcNAc termini exposed.	n-linked os	33-44	galactosidase beta 1	Homo sapiens	100-118
16970315-6	2006	Potentials for using the system in enzyme inhibition assays were demonstrated by a reaction involving the conversion of fluorescein digalactoside to fluorescent hydrolysates via beta-galactosidase and the inhibition of beta-galactosidase by diethylenetriaminepentaacetic acid.	fluorescein-digalactoside	120-145	galactosidase beta 1	Homo sapiens	178-196
17034135-0	2006	Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates.	benzoquinone ansamycin	30-52	galactosidase beta 1	Homo sapiens	83-101
17034135-1	2006	To activate prodrugs for cancer treatment, an anti-TAG-72 antibody (HuCC49DeltaCH2) was used for delivery of an activation enzyme (beta-galactosidase) to specifically activate a geldanamycin prodrug (17-AG-C2-Gal) against colon cancer.	geldanamycin	178-190	galactosidase beta 1	Homo sapiens	131-149
17034135-3	2006	Molecular docking with two different programs (Affinity and Autodock) showed that the prodrug (17-AG-C2-Gal) was unable to bind to Hsp90; however, the product (17-AG-C2), enzymatically cleaved by beta-galactosidase conjugate, bound to Hsp90 in a similar way as geldanamycin and 17-AG.	17-amino-17-demethoxygeldanamycin -C2-galactose	95-107	galactosidase beta 1	Homo sapiens	196-214
17034135-3	2006	Molecular docking with two different programs (Affinity and Autodock) showed that the prodrug (17-AG-C2-Gal) was unable to bind to Hsp90; however, the product (17-AG-C2), enzymatically cleaved by beta-galactosidase conjugate, bound to Hsp90 in a similar way as geldanamycin and 17-AG.	17-AG	95-100	galactosidase beta 1	Homo sapiens	196-214
16970315-6	2006	Potentials for using the system in enzyme inhibition assays were demonstrated by a reaction involving the conversion of fluorescein digalactoside to fluorescent hydrolysates via beta-galactosidase and the inhibition of beta-galactosidase by diethylenetriaminepentaacetic acid.	fluorescein-digalactoside	120-145	galactosidase beta 1	Homo sapiens	219-237
16970315-6	2006	Potentials for using the system in enzyme inhibition assays were demonstrated by a reaction involving the conversion of fluorescein digalactoside to fluorescent hydrolysates via beta-galactosidase and the inhibition of beta-galactosidase by diethylenetriaminepentaacetic acid.	Pentetic Acid	241-275	galactosidase beta 1	Homo sapiens	178-196
16970315-6	2006	Potentials for using the system in enzyme inhibition assays were demonstrated by a reaction involving the conversion of fluorescein digalactoside to fluorescent hydrolysates via beta-galactosidase and the inhibition of beta-galactosidase by diethylenetriaminepentaacetic acid.	Pentetic Acid	241-275	galactosidase beta 1	Homo sapiens	219-237
17052929-1	2006	GM1 gangliosidosis is an autosomal recessive glycosphingolipid storage disease caused by defects in the enzyme beta-galactosidase.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	111-129
16984130-9	2006	In knockdown experiments using NIH/3T3 fibroblasts stably expressing beta-galactosidase, it was shown that PEG chain length had a significant influence on biological activity of siRNA.	Polyethylene Glycols	107-110	galactosidase beta 1	Homo sapiens	69-87
16781666-3	2006	In the current study, we demonstrate that arginine-rich intracellular delivery (AID) peptides are able to deliver fluorescent proteins or beta-galactosidase enzyme into animal and plant cells, as well as animal tissue.	Arginine	42-50	galactosidase beta 1	Homo sapiens	138-156
16916713-0	2006	Imaging beta-galactosidase activity using 19F chemical shift imaging of LacZ gene-reporter molecule 2-fluoro-4-nitrophenol-beta-D-galactopyranoside.	2-fluoro-4-nitrophenol-beta-d-galactopyranoside	100-147	galactosidase beta 1	Homo sapiens	8-26
16916713-1	2006	2-Fluoro-4-nitrophenol-beta-D-galactopyranoside (OFPNPG) belongs to a novel class of NMR active molecules (fluoroaryl-beta-D-galactopyranosides), which are highly responsive to the action of beta-galactosidase (beta-gal).	2-fluoro-4-nitrophenol-beta-d-galactopyranoside	0-47	galactosidase beta 1	Homo sapiens	191-209
16916713-1	2006	2-Fluoro-4-nitrophenol-beta-D-galactopyranoside (OFPNPG) belongs to a novel class of NMR active molecules (fluoroaryl-beta-D-galactopyranosides), which are highly responsive to the action of beta-galactosidase (beta-gal).	2-fluoro-4-nitrophenol-beta-d-galactopyranoside	0-47	galactosidase beta 1	Homo sapiens	191-199
16916713-1	2006	2-Fluoro-4-nitrophenol-beta-D-galactopyranoside (OFPNPG) belongs to a novel class of NMR active molecules (fluoroaryl-beta-D-galactopyranosides), which are highly responsive to the action of beta-galactosidase (beta-gal).	ofpnpg	49-55	galactosidase beta 1	Homo sapiens	191-209
16916713-1	2006	2-Fluoro-4-nitrophenol-beta-D-galactopyranoside (OFPNPG) belongs to a novel class of NMR active molecules (fluoroaryl-beta-D-galactopyranosides), which are highly responsive to the action of beta-galactosidase (beta-gal).	ofpnpg	49-55	galactosidase beta 1	Homo sapiens	191-199
16916713-1	2006	2-Fluoro-4-nitrophenol-beta-D-galactopyranoside (OFPNPG) belongs to a novel class of NMR active molecules (fluoroaryl-beta-D-galactopyranosides), which are highly responsive to the action of beta-galactosidase (beta-gal).	fluoroaryl-beta-d-galactopyranosides	107-143	galactosidase beta 1	Homo sapiens	191-209
16916713-1	2006	2-Fluoro-4-nitrophenol-beta-D-galactopyranoside (OFPNPG) belongs to a novel class of NMR active molecules (fluoroaryl-beta-D-galactopyranosides), which are highly responsive to the action of beta-galactosidase (beta-gal).	fluoroaryl-beta-d-galactopyranosides	107-143	galactosidase beta 1	Homo sapiens	191-199
16916713-3	2006	Upon cleavage by beta-gal, the pH sensitive aglycone 2-fluoro-4-nitrophenol (OFPNP) is observed at a chemical shift of -59 to -61 ppm.	CHEBI:166892	44-52	galactosidase beta 1	Homo sapiens	17-25
16916713-3	2006	Upon cleavage by beta-gal, the pH sensitive aglycone 2-fluoro-4-nitrophenol (OFPNP) is observed at a chemical shift of -59 to -61 ppm.	2-fluoro-4-nitrophenol	53-75	galactosidase beta 1	Homo sapiens	17-25
16916713-3	2006	Upon cleavage by beta-gal, the pH sensitive aglycone 2-fluoro-4-nitrophenol (OFPNP) is observed at a chemical shift of -59 to -61 ppm.	ofpnp	77-82	galactosidase beta 1	Homo sapiens	17-25
16914157-4	2006	The presence of beta-Gal was detected by dual staining transfected murine skin by both immunohistochemical (alkaline phosphatase) as well as histochemical staining (5-bromo-indolyl-beta-o-galactopyranoside [Bluo-Gal]).	5-bromo-indolyl-beta-o-galactopyranoside	165-205	galactosidase beta 1	Homo sapiens	16-24
16914157-4	2006	The presence of beta-Gal was detected by dual staining transfected murine skin by both immunohistochemical (alkaline phosphatase) as well as histochemical staining (5-bromo-indolyl-beta-o-galactopyranoside [Bluo-Gal]).	5-BROMO-3-INDOLYL-beta-D-GALACTOPYRANOSIDE	207-215	galactosidase beta 1	Homo sapiens	16-24
16828709-4	2006	Using these markers in conjunction with senescence-associated beta-galactosidase expression, we have developed and screened novel nitrone based anti-oxidant compounds.	nitrones	130-137	galactosidase beta 1	Homo sapiens	62-80
16838159-0	2006	Measurement of hydrolysis kinetics of galactose-substituted fluorescein by beta-galactosidase at the toluene-water interface by spinning microtube fluorometry.	Galactose	38-47	galactosidase beta 1	Homo sapiens	75-93
16838159-0	2006	Measurement of hydrolysis kinetics of galactose-substituted fluorescein by beta-galactosidase at the toluene-water interface by spinning microtube fluorometry.	Fluorescein	60-71	galactosidase beta 1	Homo sapiens	75-93
16838159-0	2006	Measurement of hydrolysis kinetics of galactose-substituted fluorescein by beta-galactosidase at the toluene-water interface by spinning microtube fluorometry.	Toluene	101-108	galactosidase beta 1	Homo sapiens	75-93
16838159-0	2006	Measurement of hydrolysis kinetics of galactose-substituted fluorescein by beta-galactosidase at the toluene-water interface by spinning microtube fluorometry.	Water	109-114	galactosidase beta 1	Homo sapiens	75-93
16838159-1	2006	A new analytical technique, spinning microtube fluorometry (SMF), was developed and applied to the study of interfacial hydrolysis of 5-dodecanoylaminofluorescein di-beta-D: -galactopyranoside (C12FDG) by beta-galactosidase (beta-gal) in the toluene-water system.	5-dodecanoylaminofluorescein di-beta-d: -galactopyranoside	134-192	galactosidase beta 1	Homo sapiens	205-223
16838159-1	2006	A new analytical technique, spinning microtube fluorometry (SMF), was developed and applied to the study of interfacial hydrolysis of 5-dodecanoylaminofluorescein di-beta-D: -galactopyranoside (C12FDG) by beta-galactosidase (beta-gal) in the toluene-water system.	5-dodecanoylaminofluorescein di-beta-d: -galactopyranoside	134-192	galactosidase beta 1	Homo sapiens	205-213
16838159-1	2006	A new analytical technique, spinning microtube fluorometry (SMF), was developed and applied to the study of interfacial hydrolysis of 5-dodecanoylaminofluorescein di-beta-D: -galactopyranoside (C12FDG) by beta-galactosidase (beta-gal) in the toluene-water system.	5-octanoylaminofluorescein digalactopyranoside	194-200	galactosidase beta 1	Homo sapiens	205-223
16838159-1	2006	A new analytical technique, spinning microtube fluorometry (SMF), was developed and applied to the study of interfacial hydrolysis of 5-dodecanoylaminofluorescein di-beta-D: -galactopyranoside (C12FDG) by beta-galactosidase (beta-gal) in the toluene-water system.	5-octanoylaminofluorescein digalactopyranoside	194-200	galactosidase beta 1	Homo sapiens	205-213
16838159-5	2006	The kinetic experiments with the SMF method concluded that the rate-determining step of the enzymatic hydrolysis at the interface and in the aqueous phase was the 1:1 reaction of C12FDG and beta-gal and that the hydrolysis reaction rate constant at the interface at pH 7.3 was 1.84 x 10(3) M(-1)s(-1), almost equal to that in the aqueous solution, 1.76 x 10(3) M(-1)s(-1).	smf	33-36	galactosidase beta 1	Homo sapiens	190-198
16838159-5	2006	The kinetic experiments with the SMF method concluded that the rate-determining step of the enzymatic hydrolysis at the interface and in the aqueous phase was the 1:1 reaction of C12FDG and beta-gal and that the hydrolysis reaction rate constant at the interface at pH 7.3 was 1.84 x 10(3) M(-1)s(-1), almost equal to that in the aqueous solution, 1.76 x 10(3) M(-1)s(-1).	5-octanoylaminofluorescein digalactopyranoside	179-185	galactosidase beta 1	Homo sapiens	190-198
16889370-3	2006	We have developed and validated a Monte Carlo simulation model of pooling and used it to screen a library of beta-galactosidase mutants randomized in the active site to increase their activity toward fucosides.	fucosides	200-209	galactosidase beta 1	Homo sapiens	109-127
16713997-5	2006	Co-incubation with l-arginine enhanced PD, inhibited senescence associated beta-galactosidase activity, and increased telomerase activity.	Arginine	19-29	galactosidase beta 1	Homo sapiens	75-93
16889370-5	2006	In unpooled conditions, we found a total of three mutants with higher activity toward p-nitrophenyl-beta-D-fucoside than that of the wild-type beta-galactosidase, whereas when pooling 10 cells per well we found a total of approximately 10 improved mutants.	p-nitrophenyl-beta-d-fucoside	86-115	galactosidase beta 1	Homo sapiens	143-161
16337670-8	2006	For o,p"-dicofol, the beta-galactosidase induction by (-)-o,p"-dicofol (EC(50): 5.1 x 10(-7)M) was greater than the racemic mixture.	o,p'-Dicofol	4-16	galactosidase beta 1	Homo sapiens	22-40
16337670-8	2006	For o,p"-dicofol, the beta-galactosidase induction by (-)-o,p"-dicofol (EC(50): 5.1 x 10(-7)M) was greater than the racemic mixture.	(-)-o,p"-dicofol	54-70	galactosidase beta 1	Homo sapiens	22-40
16337670-8	2006	For o,p"-dicofol, the beta-galactosidase induction by (-)-o,p"-dicofol (EC(50): 5.1 x 10(-7)M) was greater than the racemic mixture.	ec	72-74	galactosidase beta 1	Homo sapiens	22-40
16516177-2	2006	Further, the regioselective transfer of sulfate to an N-acetyllactosamine derivative could be realised with soluble chimeric GP3ST, also in combination with Lac transglycosylation by means of beta-galactosidase.	Sulfates	40-47	galactosidase beta 1	Homo sapiens	192-210
16516177-2	2006	Further, the regioselective transfer of sulfate to an N-acetyllactosamine derivative could be realised with soluble chimeric GP3ST, also in combination with Lac transglycosylation by means of beta-galactosidase.	N-acetyllactosamine	54-73	galactosidase beta 1	Homo sapiens	192-210
16683771-1	2006	In this communication, single molecules of beta-galactosidase were captured on a 1 mm femtoliter array using biotin-streptavidin binding.	Biotin	109-115	galactosidase beta 1	Homo sapiens	43-61
16569047-7	2006	The release of beta-galactosidase showed a similar trend to that of isoflavone.	Isoflavones	68-78	galactosidase beta 1	Homo sapiens	15-33
16739972-2	2006	The well-known beta-gal substrate analog, o-nitrophenyl beta-d-galactopyranoside, yields the visibly colored, o-nitrophenol product upon hydrolysis, whereas the substrate, p-aminophenyl beta-D-galactopyranoside, gives rise to an electrooxidizable product, p-aminophenol.	2-nitrophenylgalactoside	42-80	galactosidase beta 1	Homo sapiens	15-23
16739972-2	2006	The well-known beta-gal substrate analog, o-nitrophenyl beta-d-galactopyranoside, yields the visibly colored, o-nitrophenol product upon hydrolysis, whereas the substrate, p-aminophenyl beta-D-galactopyranoside, gives rise to an electrooxidizable product, p-aminophenol.	2-nitrophenol	110-123	galactosidase beta 1	Homo sapiens	15-23
16739972-2	2006	The well-known beta-gal substrate analog, o-nitrophenyl beta-d-galactopyranoside, yields the visibly colored, o-nitrophenol product upon hydrolysis, whereas the substrate, p-aminophenyl beta-D-galactopyranoside, gives rise to an electrooxidizable product, p-aminophenol.	4-aminophenyl-beta-galactoside	172-210	galactosidase beta 1	Homo sapiens	15-23
16739972-2	2006	The well-known beta-gal substrate analog, o-nitrophenyl beta-d-galactopyranoside, yields the visibly colored, o-nitrophenol product upon hydrolysis, whereas the substrate, p-aminophenyl beta-D-galactopyranoside, gives rise to an electrooxidizable product, p-aminophenol.	4-aminophenol	256-269	galactosidase beta 1	Homo sapiens	15-23
16739972-3	2006	These beta-gal substrates made possible the demonstration of both photometric and electrochemical signal transduction schemes for beta-gal-based EMAT detection of estradiol (as the estradiol-bovine serum albumin (E-BSA) conjugate).	Estradiol	163-172	galactosidase beta 1	Homo sapiens	6-14
16739972-3	2006	These beta-gal substrates made possible the demonstration of both photometric and electrochemical signal transduction schemes for beta-gal-based EMAT detection of estradiol (as the estradiol-bovine serum albumin (E-BSA) conjugate).	Estradiol	163-172	galactosidase beta 1	Homo sapiens	130-138
16739972-4	2006	The EMAT system is composed of the reporter enzyme, beta-gal, with covalently attached estradiol, and estrogen antibody, which inhibits enzyme activity of the beta-gal-estradiol conjugate up to approximately 75%.	Estradiol	168-177	galactosidase beta 1	Homo sapiens	52-60
16739972-4	2006	The EMAT system is composed of the reporter enzyme, beta-gal, with covalently attached estradiol, and estrogen antibody, which inhibits enzyme activity of the beta-gal-estradiol conjugate up to approximately 75%.	Estradiol	168-177	galactosidase beta 1	Homo sapiens	159-167
16584916-3	2006	We found that N-acetyl-beta-d-hexosaminidase (HEX) was significantly increased and beta-galactosidase and alpha-mannosidase also showed an increase in Lyme arthritis patients compared to healthy persons and normalised after treatment with doxycycline.	Doxycycline	239-250	galactosidase beta 1	Homo sapiens	83-101
16569047-10	2006	The present study indicated that isoflavone or beta-galactosidase could be microencapsulated with fatty acid esters and released effectively in simulated intestinal condition.	Fatty Acids	98-115	galactosidase beta 1	Homo sapiens	47-65
16626397-2	2006	The most widely used biomarker for senescent and aging cells is senescence-associated beta-galactosidase (SA-beta-gal), which is defined as beta-galactosidase activity detectable at pH 6.0 in senescent cells, but the origin of SA-beta-gal and its cellular roles in senescence are not known.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	106-117	galactosidase beta 1	Homo sapiens	86-104
16626397-2	2006	The most widely used biomarker for senescent and aging cells is senescence-associated beta-galactosidase (SA-beta-gal), which is defined as beta-galactosidase activity detectable at pH 6.0 in senescent cells, but the origin of SA-beta-gal and its cellular roles in senescence are not known.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	106-117	galactosidase beta 1	Homo sapiens	140-158
16626397-2	2006	The most widely used biomarker for senescent and aging cells is senescence-associated beta-galactosidase (SA-beta-gal), which is defined as beta-galactosidase activity detectable at pH 6.0 in senescent cells, but the origin of SA-beta-gal and its cellular roles in senescence are not known.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	227-238	galactosidase beta 1	Homo sapiens	86-104
16626397-2	2006	The most widely used biomarker for senescent and aging cells is senescence-associated beta-galactosidase (SA-beta-gal), which is defined as beta-galactosidase activity detectable at pH 6.0 in senescent cells, but the origin of SA-beta-gal and its cellular roles in senescence are not known.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	227-238	galactosidase beta 1	Homo sapiens	140-158
16626397-3	2006	We demonstrate here that SA-beta-gal activity is expressed from GLB1, the gene encoding lysosomal beta-D-galactosidase, the activity of which is typically measured at acidic pH 4.5.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	25-36	galactosidase beta 1	Homo sapiens	64-68
16626397-7	2006	SA-beta-gal induction during senescence was due at least in part to increased expression of the lysosomal beta-galactosidase protein.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	0-11	galactosidase beta 1	Homo sapiens	106-124
16636462-0	2006	Enzymatic production of highly soluble myricitrin glycosides using beta-galactosidase.	myricitrin glycosides	39-60	galactosidase beta 1	Homo sapiens	67-85
16636462-4	2006	Myricitrin was galactosylated by beta-galactosidase from Bacillus circulans using lactose as a sugar donor.	myricitrin	0-10	galactosidase beta 1	Homo sapiens	33-51
16636462-4	2006	Myricitrin was galactosylated by beta-galactosidase from Bacillus circulans using lactose as a sugar donor.	Lactose	82-89	galactosidase beta 1	Homo sapiens	33-51
16636462-4	2006	Myricitrin was galactosylated by beta-galactosidase from Bacillus circulans using lactose as a sugar donor.	Sugars	95-100	galactosidase beta 1	Homo sapiens	33-51
16648559-9	2006	However, a larger population of senescence-activated beta-galactosidase-positive cells was seen in IUdR/methoxyamine/ionizing radiation-treated cells, which was correlated with the increased activation of the senescence factors p53 and pRb.	methoxyamine	104-116	galactosidase beta 1	Homo sapiens	53-71
16495920-4	2006	Documented increases in beta-galactosidase activity suggest that boric acid induces conversion to a senescent-like cellular phenotype.	boric acid	65-75	galactosidase beta 1	Homo sapiens	24-42
16539386-0	2006	Synthesis and characterization of novel lacZ gene reporter molecules: detection of beta-galactosidase activity by 19F nuclear magnetic resonance of polyglycosylated fluorinated vitamin B6.	Vitamin B 6	177-187	galactosidase beta 1	Homo sapiens	83-101
16539386-4	2006	We have previously demonstrated the ability to detect beta-galactosidase (beta-gal) activity on the basis of 19F NMR chemical shift associated with release of fluorophenyl aglycons from galactopyranoside conjugates.	aglycons	172-180	galactosidase beta 1	Homo sapiens	54-72
16539386-4	2006	We have previously demonstrated the ability to detect beta-galactosidase (beta-gal) activity on the basis of 19F NMR chemical shift associated with release of fluorophenyl aglycons from galactopyranoside conjugates.	aglycons	172-180	galactosidase beta 1	Homo sapiens	54-62
16539386-4	2006	We have previously demonstrated the ability to detect beta-galactosidase (beta-gal) activity on the basis of 19F NMR chemical shift associated with release of fluorophenyl aglycons from galactopyranoside conjugates.	Galactose	186-203	galactosidase beta 1	Homo sapiens	54-72
16539386-4	2006	We have previously demonstrated the ability to detect beta-galactosidase (beta-gal) activity on the basis of 19F NMR chemical shift associated with release of fluorophenyl aglycons from galactopyranoside conjugates.	Galactose	186-203	galactosidase beta 1	Homo sapiens	54-62
16539386-7	2006	Compounds 4, 12, and 13 all show promising characteristics including highly sensitive 19F NMR response to beta-gal activity (Deltadelta=9.0 approximately 9.4 ppm), minimal toxicity for substrate or aglycon, and good water solubility.	deltadelta	125-135	galactosidase beta 1	Homo sapiens	106-114
16508959-8	2006	Both IL-1beta and H2O2 up-regulated caveolin 1 messenger RNA and protein levels, and both treatments induced marked expression of senescent phenotypes: altered cellular morphology, cell growth arrest, telomere erosion, and specific senescence-associated beta-galactosidase activity.	Hydrogen Peroxide	18-22	galactosidase beta 1	Homo sapiens	254-272
16544977-9	2006	In control (beta-Gal-infected) HuH7 cells, exposure to H2O2 produced a dose-dependent increase in apoptosis, regardless of NF-kappaB status.	Hydrogen Peroxide	55-59	galactosidase beta 1	Homo sapiens	12-20
16143503-1	2006	Using a fluorescein di-beta-D-galactopyranoside (FDG) substrate we show that in live cells of an estrogen-sensitive yeast strain RMY/ER-ERE with human estrogen receptor (ERalpha) gene and the lacZ gene which encodes beta-galactosidase, the uptake of 17beta-estradiol (E2) and the subsequent production of beta-galactosidase enzyme occur quite rapidly, with maximal enzyme-catalyzed product formation evident after about 30 min of exposure to E2.	fluorescein-digalactoside	8-47	galactosidase beta 1	Homo sapiens	216-234
16143503-1	2006	Using a fluorescein di-beta-D-galactopyranoside (FDG) substrate we show that in live cells of an estrogen-sensitive yeast strain RMY/ER-ERE with human estrogen receptor (ERalpha) gene and the lacZ gene which encodes beta-galactosidase, the uptake of 17beta-estradiol (E2) and the subsequent production of beta-galactosidase enzyme occur quite rapidly, with maximal enzyme-catalyzed product formation evident after about 30 min of exposure to E2.	fluorescein-digalactoside	49-52	galactosidase beta 1	Homo sapiens	216-234
16143503-1	2006	Using a fluorescein di-beta-D-galactopyranoside (FDG) substrate we show that in live cells of an estrogen-sensitive yeast strain RMY/ER-ERE with human estrogen receptor (ERalpha) gene and the lacZ gene which encodes beta-galactosidase, the uptake of 17beta-estradiol (E2) and the subsequent production of beta-galactosidase enzyme occur quite rapidly, with maximal enzyme-catalyzed product formation evident after about 30 min of exposure to E2.	fluorescein-digalactoside	49-52	galactosidase beta 1	Homo sapiens	305-323
16442104-5	2006	Treatment of IMR-90 cells with CKII inhibitors 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and apigenin led cells to acquire a senescent phenotype as judged by the senescence-associated beta-galactosidase marker and overexpression of p53 and p21(Waf-1).	Dichlororibofuranosylbenzimidazole	47-95	galactosidase beta 1	Homo sapiens	191-209
16112873-5	2006	However, when Grx2 was fused to either the 27 kDa green fluorescent protein or the 116 kDa beta-galactosidase, the fusion proteins lost their ability to bind glutathione-Sepharose.	Glutathione	158-169	galactosidase beta 1	Homo sapiens	91-109
16185878-0	2006	Synthesis and evaluation of novel enhanced gene reporter molecules: detection of beta-galactosidase activity using 19F NMR of trifluoromethylated aryl beta-D-galactopyranosides.	trifluoromethylated aryl beta-d-galactopyranosides	126-176	galactosidase beta 1	Homo sapiens	81-99
18200779-2	2006	Administration of small, sub-antihypertensive dosages of nifedipine has been associated with a decrease in beta-galactosidase stain-positive cells (which is marker of cellular aging) and in atherosclerotic plaque area in an experimental model.	Nifedipine	57-67	galactosidase beta 1	Homo sapiens	107-125
16257520-8	2006	In in vivo-animal studies blue color was observed with X-gal (4-chloro-5-bromo-3-indolyl-beta-galactosidase) staining of histological stomach and small intestine sections after oral administration of pDNA-chitosan microparticles as an indicator of exogeneous gene expression.	5-bromo-4-chloro-3-indolyl beta-galactoside	55-60	galactosidase beta 1	Homo sapiens	89-107
16257520-8	2006	In in vivo-animal studies blue color was observed with X-gal (4-chloro-5-bromo-3-indolyl-beta-galactosidase) staining of histological stomach and small intestine sections after oral administration of pDNA-chitosan microparticles as an indicator of exogeneous gene expression.	4-chloro-5-bromo-3-indolyl	62-88	galactosidase beta 1	Homo sapiens	89-107
16428019-8	2006	In a yeast-based ERalpha assay, all test substances and 17beta-estradiol as endogenous agonist, showed a significant induction of beta-galactosidase activity.	Estradiol	56-72	galactosidase beta 1	Homo sapiens	130-148
16428019-9	2006	The test compounds at the concentration of 5 x 10(-6) M could achieve 59-121% of the beta-galactosidase induction obtained with 10(-8) M 17beta-estradiol (100%).	Estradiol	137-153	galactosidase beta 1	Homo sapiens	85-103
16170353-4	2006	Here, we show that Sirt1 inhibitor, Sirtinol, induced senescence-like growth arrest characterized by induction of senescence-associated beta-galactosidase activity and increased expression of plasminogen activator inhibitor 1 in human breast cancer MCF-7 cells and lung cancer H1299 cells.	sirtinol	36-44	galactosidase beta 1	Homo sapiens	136-154
16112873-5	2006	However, when Grx2 was fused to either the 27 kDa green fluorescent protein or the 116 kDa beta-galactosidase, the fusion proteins lost their ability to bind glutathione-Sepharose.	Sepharose	170-179	galactosidase beta 1	Homo sapiens	91-109
16468641-0	2006	[Relief effect of beta-galactosidase genetically engineered lactococcus lactis on the cell toxicity caused by lactose].	Lactose	110-117	galactosidase beta 1	Homo sapiens	18-36
16468641-1	2006	OBJECTIVE: To assess the relief effect of beta-galactosidase genetically engineered Lactococcus lactis on the cell toxicity caused by lactose in vitro.	Lactose	134-141	galactosidase beta 1	Homo sapiens	42-60
16468641-5	2006	CONCLUSION: The beta-galactosidase genetically engineered Lactococcus lactis has significant relief effect on the cell toxicity caused by lactose in vitro, which lays a foundation for food-grade alternation of this bacterium.	Lactose	138-145	galactosidase beta 1	Homo sapiens	16-34
16160862-3	2005	The general procedure proposed has been particularized and applied to experimental results obtained with two enzymatic reactions carried out in a hollow-fibre reactor, enzymatic hydrolysis of lactose by beta-galactosidase and glucose-fructose isomerization by glucose isomerase.	Lactose	192-199	galactosidase beta 1	Homo sapiens	203-221
16273243-7	2005	beta-galactosidase expression was measured by X-Gal staining in 7.0% of HMG, 17.0% of HOSM-1 and 11.5% of HOSM-2 cells.	Acetaminophen	46-47	galactosidase beta 1	Homo sapiens	0-18
16273243-7	2005	beta-galactosidase expression was measured by X-Gal staining in 7.0% of HMG, 17.0% of HOSM-1 and 11.5% of HOSM-2 cells.	cyclohexenoesculetin-beta-galactoside	48-51	galactosidase beta 1	Homo sapiens	0-18
16273243-7	2005	beta-galactosidase expression was measured by X-Gal staining in 7.0% of HMG, 17.0% of HOSM-1 and 11.5% of HOSM-2 cells.	Menotropins	72-75	galactosidase beta 1	Homo sapiens	0-18
15870702-1	2005	Chronic exposure of many human hepatoma cell lines to a low dose (LD) of doxorubicin induced a senescence-like phenotype (SLP) accompanied by enlargement of cells and increased senescence-associated beta-galactosidase activity.	Doxorubicin	73-84	galactosidase beta 1	Homo sapiens	199-217
16425153-3	2005	The X-gal stain was used to detect the activity of the expressed beta-galactosidase enzyme.	5-bromo-4-chloro-3-indolyl beta-galactoside	4-9	galactosidase beta 1	Homo sapiens	65-83
21180149-2	2005	METHODS: The perfluoropropane-exposed sonicated dextrose albumin(PESDA) microbubbles were made and mixed with indicated volume reporter gene encoding beta-galactosidase prior to gene transfection.	perflutren	13-29	galactosidase beta 1	Homo sapiens	150-168
16202243-5	2005	The synthesis of beta-galactosidase from the GGTII-lacZ fusion gene was significantly enhanced by NO-generating SNP and hydrogen peroxide in the wildtype yeast cells.	Hydrogen Peroxide	120-137	galactosidase beta 1	Homo sapiens	17-35
16202243-8	2005	Fermentable carbon sources, such as glucose (at low concentrations), lactose and sucrose, as a sole carbon source, enhanced the synthesis of beta-galactosidase from the GGTII-lacZ fusion gene in wildtype KP1 cells but not in Pap1-negative cells.	Carbon	12-18	galactosidase beta 1	Homo sapiens	141-159
16202243-8	2005	Fermentable carbon sources, such as glucose (at low concentrations), lactose and sucrose, as a sole carbon source, enhanced the synthesis of beta-galactosidase from the GGTII-lacZ fusion gene in wildtype KP1 cells but not in Pap1-negative cells.	Glucose	36-43	galactosidase beta 1	Homo sapiens	141-159
16173798-2	2005	Polycations of dextran grafted with MQ ammonium oligoamines of two to four amino groups were investigated for their ability to cause pCMV-GFP encoding for green fluorescence protein and beta-Gal encoding for beta-galactosidase protein transfection on EPC and HEK-293 cell lines.	Dextrans	15-22	galactosidase beta 1	Homo sapiens	208-226
16004951-2	2005	This enzymatic activity has generally been measured by staining cells with the chromogenic substrate 5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside (X-gal) at pH 6.0, a reaction condition that suppresses lysosomal beta-galactosidase activity sufficiently to ensure that most nonsenescent cells will appear unstained.	5-bromo-4-chloro-3-indolyl beta-galactoside	101-152	galactosidase beta 1	Homo sapiens	219-237
16004951-2	2005	This enzymatic activity has generally been measured by staining cells with the chromogenic substrate 5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside (X-gal) at pH 6.0, a reaction condition that suppresses lysosomal beta-galactosidase activity sufficiently to ensure that most nonsenescent cells will appear unstained.	5-bromo-4-chloro-3-indolyl beta-galactoside	154-159	galactosidase beta 1	Homo sapiens	219-237
15703907-1	2005	A novel strain of Bifidobacterium bifidum NCIMB 41171, isolated from a faecal sample from a healthy human volunteer and able to express beta-galactosidase activity, was used in synthesis reactions for the production of galactooligosaccharide from lactose.	4'-Galactooligosaccharide	219-241	galactosidase beta 1	Homo sapiens	136-154
15703907-1	2005	A novel strain of Bifidobacterium bifidum NCIMB 41171, isolated from a faecal sample from a healthy human volunteer and able to express beta-galactosidase activity, was used in synthesis reactions for the production of galactooligosaccharide from lactose.	Lactose	247-254	galactosidase beta 1	Homo sapiens	136-154
15703907-2	2005	The beta-galactosidase activity of whole bifidobacterial cells showed an optimum activity at pH 6.8-7.0 and 40 degrees C. The transgalactosylation activity of the B. bifidum cells from 50% (w/w) lactose resulted in a galactooligosaccharide mixture (20% w/w) comprising (w/w): 25% disaccharides, 35% trisaccharides, 25% tetrasaccharides and 15% pentasaccharides.	Lactose	195-202	galactosidase beta 1	Homo sapiens	4-22
15703907-2	2005	The beta-galactosidase activity of whole bifidobacterial cells showed an optimum activity at pH 6.8-7.0 and 40 degrees C. The transgalactosylation activity of the B. bifidum cells from 50% (w/w) lactose resulted in a galactooligosaccharide mixture (20% w/w) comprising (w/w): 25% disaccharides, 35% trisaccharides, 25% tetrasaccharides and 15% pentasaccharides.	4'-Galactooligosaccharide	217-239	galactosidase beta 1	Homo sapiens	4-22
15703907-2	2005	The beta-galactosidase activity of whole bifidobacterial cells showed an optimum activity at pH 6.8-7.0 and 40 degrees C. The transgalactosylation activity of the B. bifidum cells from 50% (w/w) lactose resulted in a galactooligosaccharide mixture (20% w/w) comprising (w/w): 25% disaccharides, 35% trisaccharides, 25% tetrasaccharides and 15% pentasaccharides.	Disaccharides	280-293	galactosidase beta 1	Homo sapiens	4-22
15703907-2	2005	The beta-galactosidase activity of whole bifidobacterial cells showed an optimum activity at pH 6.8-7.0 and 40 degrees C. The transgalactosylation activity of the B. bifidum cells from 50% (w/w) lactose resulted in a galactooligosaccharide mixture (20% w/w) comprising (w/w): 25% disaccharides, 35% trisaccharides, 25% tetrasaccharides and 15% pentasaccharides.	Trisaccharides	299-313	galactosidase beta 1	Homo sapiens	4-22
15703907-2	2005	The beta-galactosidase activity of whole bifidobacterial cells showed an optimum activity at pH 6.8-7.0 and 40 degrees C. The transgalactosylation activity of the B. bifidum cells from 50% (w/w) lactose resulted in a galactooligosaccharide mixture (20% w/w) comprising (w/w): 25% disaccharides, 35% trisaccharides, 25% tetrasaccharides and 15% pentasaccharides.	tetrasaccharides	319-335	galactosidase beta 1	Homo sapiens	4-22
15703907-2	2005	The beta-galactosidase activity of whole bifidobacterial cells showed an optimum activity at pH 6.8-7.0 and 40 degrees C. The transgalactosylation activity of the B. bifidum cells from 50% (w/w) lactose resulted in a galactooligosaccharide mixture (20% w/w) comprising (w/w): 25% disaccharides, 35% trisaccharides, 25% tetrasaccharides and 15% pentasaccharides.	pentasaccharides	344-360	galactosidase beta 1	Homo sapiens	4-22
16228649-3	2005	This dipeptide was capable of hydrolyzing ONPG at a specific activity lower only 1000 fold than that of beta galactosidase.	Dipeptides	5-14	galactosidase beta 1	Homo sapiens	104-122
16332343-2	2005	beta-Galactosidase is the bacterial enzyme which catalyzes the first step of lactose fermentation in the colon.	Lactose	77-84	galactosidase beta 1	Homo sapiens	0-18
16332343-3	2005	We propose a practical method to differentiate and identify bacteria with beta-galactosidase activity in faeces which combines a colony-lift filter assay with X-gal (5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside) as substrate for differentiation and the fluorescent in situ hybridization technique for identification.	5-bromo-4-chloro-3-indolyl beta-galactoside	159-164	galactosidase beta 1	Homo sapiens	74-92
16332343-3	2005	We propose a practical method to differentiate and identify bacteria with beta-galactosidase activity in faeces which combines a colony-lift filter assay with X-gal (5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside) as substrate for differentiation and the fluorescent in situ hybridization technique for identification.	5-bromo-4-chloro-3-indolyl beta-galactoside	166-217	galactosidase beta 1	Homo sapiens	74-92
16202243-8	2005	Fermentable carbon sources, such as glucose (at low concentrations), lactose and sucrose, as a sole carbon source, enhanced the synthesis of beta-galactosidase from the GGTII-lacZ fusion gene in wildtype KP1 cells but not in Pap1-negative cells.	Lactose	69-76	galactosidase beta 1	Homo sapiens	141-159
16202243-8	2005	Fermentable carbon sources, such as glucose (at low concentrations), lactose and sucrose, as a sole carbon source, enhanced the synthesis of beta-galactosidase from the GGTII-lacZ fusion gene in wildtype KP1 cells but not in Pap1-negative cells.	Sucrose	81-88	galactosidase beta 1	Homo sapiens	141-159
16202243-8	2005	Fermentable carbon sources, such as glucose (at low concentrations), lactose and sucrose, as a sole carbon source, enhanced the synthesis of beta-galactosidase from the GGTII-lacZ fusion gene in wildtype KP1 cells but not in Pap1-negative cells.	Carbon	100-106	galactosidase beta 1	Homo sapiens	141-159
16202243-9	2005	Glycerol, a non-fermentable carbon source, was also able to induce the synthesis of beta-galactosidase from the fusion gene, but other non-fermentable carbon sources such as acetate and ethanol were not.	Glycerol	0-8	galactosidase beta 1	Homo sapiens	84-102
16202243-9	2005	Glycerol, a non-fermentable carbon source, was also able to induce the synthesis of beta-galactosidase from the fusion gene, but other non-fermentable carbon sources such as acetate and ethanol were not.	Carbon	28-34	galactosidase beta 1	Homo sapiens	84-102
16202243-9	2005	Glycerol, a non-fermentable carbon source, was also able to induce the synthesis of beta-galactosidase from the fusion gene, but other non-fermentable carbon sources such as acetate and ethanol were not.	Carbon	151-157	galactosidase beta 1	Homo sapiens	84-102
16202243-9	2005	Glycerol, a non-fermentable carbon source, was also able to induce the synthesis of beta-galactosidase from the fusion gene, but other non-fermentable carbon sources such as acetate and ethanol were not.	Acetates	174-181	galactosidase beta 1	Homo sapiens	84-102
16202243-9	2005	Glycerol, a non-fermentable carbon source, was also able to induce the synthesis of beta-galactosidase from the fusion gene, but other non-fermentable carbon sources such as acetate and ethanol were not.	Ethanol	186-193	galactosidase beta 1	Homo sapiens	84-102
16202243-11	2005	Nitrogen starvation was also able to induce the synthesis of beta-galactosidase from the GGTII-lacZ fusiongene in a Pap1-dependent manner.	Nitrogen	0-8	galactosidase beta 1	Homo sapiens	61-79
16039999-3	2005	Incubation with aspirin inhibited senescence-associated beta-galactosidase activity and increased telomerase activity.	Aspirin	16-23	galactosidase beta 1	Homo sapiens	56-74
15963932-2	2005	We screened polymers from a library of beta-amino esters for their ability to augment transgene expression as measured by beta-galactosidase activity and cellular immune responses.	Polymers	12-20	galactosidase beta 1	Homo sapiens	122-140
15963932-2	2005	We screened polymers from a library of beta-amino esters for their ability to augment transgene expression as measured by beta-galactosidase activity and cellular immune responses.	beta-amino esters	39-56	galactosidase beta 1	Homo sapiens	122-140
15867375-12	2005	Actin staining of S1P stimulated U118 cells overexpressing beta-galactosidase resulted in pronounced stress fiber formation that was exacerbated by S1P2 overexpression, partially blocked by S1P1, or totally abolished by pretreatment with Y-27632.	Y 27632	238-245	galactosidase beta 1	Homo sapiens	59-77
15932276-2	2005	The insertion of two copies of the human interferon beta SAR element at the 5" and 3" flanking regions of the beta-galactosidase reporter gene increased the frequency of beta-galactosidase positive colonies by up to 75% and enhanced beta-galactosidase expression by 15- to 20-fold after G418 selection or 30- to 40-fold at the initial stage of the MTX selection procedure.	antibiotic G 418	287-291	galactosidase beta 1	Homo sapiens	110-128
15932276-2	2005	The insertion of two copies of the human interferon beta SAR element at the 5" and 3" flanking regions of the beta-galactosidase reporter gene increased the frequency of beta-galactosidase positive colonies by up to 75% and enhanced beta-galactosidase expression by 15- to 20-fold after G418 selection or 30- to 40-fold at the initial stage of the MTX selection procedure.	antibiotic G 418	287-291	galactosidase beta 1	Homo sapiens	170-188
15932276-2	2005	The insertion of two copies of the human interferon beta SAR element at the 5" and 3" flanking regions of the beta-galactosidase reporter gene increased the frequency of beta-galactosidase positive colonies by up to 75% and enhanced beta-galactosidase expression by 15- to 20-fold after G418 selection or 30- to 40-fold at the initial stage of the MTX selection procedure.	antibiotic G 418	287-291	galactosidase beta 1	Homo sapiens	170-188
15932276-2	2005	The insertion of two copies of the human interferon beta SAR element at the 5" and 3" flanking regions of the beta-galactosidase reporter gene increased the frequency of beta-galactosidase positive colonies by up to 75% and enhanced beta-galactosidase expression by 15- to 20-fold after G418 selection or 30- to 40-fold at the initial stage of the MTX selection procedure.	Methotrexate	348-351	galactosidase beta 1	Homo sapiens	110-128
15932276-2	2005	The insertion of two copies of the human interferon beta SAR element at the 5" and 3" flanking regions of the beta-galactosidase reporter gene increased the frequency of beta-galactosidase positive colonies by up to 75% and enhanced beta-galactosidase expression by 15- to 20-fold after G418 selection or 30- to 40-fold at the initial stage of the MTX selection procedure.	Methotrexate	348-351	galactosidase beta 1	Homo sapiens	170-188
15932276-2	2005	The insertion of two copies of the human interferon beta SAR element at the 5" and 3" flanking regions of the beta-galactosidase reporter gene increased the frequency of beta-galactosidase positive colonies by up to 75% and enhanced beta-galactosidase expression by 15- to 20-fold after G418 selection or 30- to 40-fold at the initial stage of the MTX selection procedure.	Methotrexate	348-351	galactosidase beta 1	Homo sapiens	170-188
15849197-8	2005	Cleavage of G1-G2 by aggrecanase was markedly reduced when keratan sulfate chains were removed by treatment with keratanase, keratanase II, endo-beta-galactosidase, or N-glycosidase F. These results indicate that modification of oligosaccharides in the aggrecan interglobular domain with keratan sulfate, most likely at asparagine residue 368, potentiates aggrecanase activity in this part of the core protein.	Keratan Sulfate	59-74	galactosidase beta 1	Homo sapiens	145-163
15850798-4	2005	Treatment of Intestine-407 cells with neuraminidase led to a significant increase in the binding of type A PTX, while further digestion of cell surface oligosaccharides by beta-galactosidase and beta-N-acetylhexosaminidase decreased the binding.	Oligosaccharides	152-168	galactosidase beta 1	Homo sapiens	172-190
15784258-8	2005	The resultant beta-galactosidase enzyme is active, conferring a Lac+ phenotype (blue colonies on indicator 5-bromo-4-chloro-3-indolyl beta-D-galactoside (X-gal) plates), while induction of NS3 expression results in loss of beta-galactosidase activity (transparent colonies on X-gal plates).	Lactose	64-67	galactosidase beta 1	Homo sapiens	14-32
15604092-4	2005	In-gel deglycosylation of the electrophoretically separated ZPA protein and comparison of the pattern obtained from the native, the desialylated and the endo-beta-galactosidase-treated glycoprotein allowed the assignment of the glycan structures by MALDI-TOF MS by considering the reported oligosaccharide structures.	Polysaccharides	228-234	galactosidase beta 1	Homo sapiens	158-176
15901356-7	2005	beta-glucosidase or beta-galactosidase (lactase/phloridzin hydrolase, LPH) and alpha-glucosidase (sucrase-isomaltase) had different pH-dependent activities for disaccharide conjugates.	Disaccharides	160-172	galactosidase beta 1	Homo sapiens	20-38
16787321-0	2005	Synthesis and evaluation of a novel gene reporter molecule: detection of beta-galactosidase activity using 19F NMR of a fluorinated vitamin B6 conjugate+.	Vitamin B 6	132-142	galactosidase beta 1	Homo sapiens	73-91
15784258-8	2005	The resultant beta-galactosidase enzyme is active, conferring a Lac+ phenotype (blue colonies on indicator 5-bromo-4-chloro-3-indolyl beta-D-galactoside (X-gal) plates), while induction of NS3 expression results in loss of beta-galactosidase activity (transparent colonies on X-gal plates).	5-bromo-4-chloro-3-indolyl beta-galactoside	107-152	galactosidase beta 1	Homo sapiens	14-32
15784258-8	2005	The resultant beta-galactosidase enzyme is active, conferring a Lac+ phenotype (blue colonies on indicator 5-bromo-4-chloro-3-indolyl beta-D-galactoside (X-gal) plates), while induction of NS3 expression results in loss of beta-galactosidase activity (transparent colonies on X-gal plates).	5-bromo-4-chloro-3-indolyl beta-galactoside	154-159	galactosidase beta 1	Homo sapiens	14-32
15864436-0	2005	Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2"-deoxycytidine.	Butyrates	96-104	galactosidase beta 1	Homo sapiens	62-81
15762555-4	2005	Using fluorescein di-beta-d-galactopyranoside, which is a fluorogenic substrate for the intracellular enzyme beta-galactosidase, we also assayed the activity of this enzyme from a single cell following the laser-induced lysis of the cell.	fluorescein-digalactoside	6-45	galactosidase beta 1	Homo sapiens	109-127
15711127-6	2005	However, discodermolide, but not Taxol, also produced a large increase in senescence-associated beta-galactosidase activity and altered levels of known senescence markers.	discodermolide	9-23	galactosidase beta 1	Homo sapiens	96-114
15711127-7	2005	Although some of these differences between Taxol and discodermolide were dose dependent, only discodermolide produced a doxorubicin-like induction of a senescence phenotype, including a senescence-associated beta-galactosidase activity, up-regulation of PAI-1 and p66Shc, and a strong, sustained, Erk1/2 activation.	discodermolide	94-108	galactosidase beta 1	Homo sapiens	208-226
15864436-0	2005	Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2"-deoxycytidine.	trichostatin A	106-119	galactosidase beta 1	Homo sapiens	62-81
15864436-0	2005	Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2"-deoxycytidine.	Decitabine	125-147	galactosidase beta 1	Homo sapiens	62-81
15661609-11	2005	Activity of beta-galactosidase in the presence of a toxaphene solution was significantly increased after 6 and 9 h irradiation, reaching values that were 2.4- and 3.1-fold higher, respectively, than the control, which exceeded the criteria of significant genotoxicity.	Toxaphene	52-61	galactosidase beta 1	Homo sapiens	12-30
15631888-1	2005	In lineage tracing analysis, the beta-galactosidase (beta-gal) gene is a commonly used as a reporter gene because it is relatively stable and highly sensitive in histochemical detection using 5-bromo-4-chloro-3-indolyl-beta-d-galactoside (X-gal).	5-bromo-4-chloro-3-indolyl beta-galactoside	192-237	galactosidase beta 1	Homo sapiens	33-51
15631888-1	2005	In lineage tracing analysis, the beta-galactosidase (beta-gal) gene is a commonly used as a reporter gene because it is relatively stable and highly sensitive in histochemical detection using 5-bromo-4-chloro-3-indolyl-beta-d-galactoside (X-gal).	5-bromo-4-chloro-3-indolyl beta-galactoside	192-237	galactosidase beta 1	Homo sapiens	33-41
15631888-1	2005	In lineage tracing analysis, the beta-galactosidase (beta-gal) gene is a commonly used as a reporter gene because it is relatively stable and highly sensitive in histochemical detection using 5-bromo-4-chloro-3-indolyl-beta-d-galactoside (X-gal).	5-bromo-4-chloro-3-indolyl beta-galactoside	239-244	galactosidase beta 1	Homo sapiens	33-51
15631888-1	2005	In lineage tracing analysis, the beta-galactosidase (beta-gal) gene is a commonly used as a reporter gene because it is relatively stable and highly sensitive in histochemical detection using 5-bromo-4-chloro-3-indolyl-beta-d-galactoside (X-gal).	5-bromo-4-chloro-3-indolyl beta-galactoside	239-244	galactosidase beta 1	Homo sapiens	33-41
15631888-3	2005	X-gal staining, which involves the precipitate formed by the reaction between beta-gal and X-gal, is usually recognized as a light blue or green reaction product on light microscopic (LM) examination.	5-bromo-4-chloro-3-indolyl beta-galactoside	0-5	galactosidase beta 1	Homo sapiens	78-86
15658879-10	2005	However, when galactose- and lactose-GA were incubated with beta-galactosidase in the cells, their anticancer activity was enhanced by 3- to 40-fold.	Galactose	14-23	galactosidase beta 1	Homo sapiens	60-78
15658879-10	2005	However, when galactose- and lactose-GA were incubated with beta-galactosidase in the cells, their anticancer activity was enhanced by 3- to 40-fold.	Lactose	16-23	galactosidase beta 1	Homo sapiens	60-78
15658879-11	2005	The results suggest that GA can be inactivated by glycosylation of C-17-position and reactivated for anticancer activity by beta-galactosidase.	geldanamycin	25-27	galactosidase beta 1	Homo sapiens	124-142
15658879-12	2005	Therefore, galactose-GA can be exploited in antibody-directed enzyme prodrug therapy (ADEPT) with beta-galactosidase for enzyme-specific activation in tumors to increase tumor selectivity.	Galactose	11-20	galactosidase beta 1	Homo sapiens	98-116
15658879-12	2005	Therefore, galactose-GA can be exploited in antibody-directed enzyme prodrug therapy (ADEPT) with beta-galactosidase for enzyme-specific activation in tumors to increase tumor selectivity.	geldanamycin	21-23	galactosidase beta 1	Homo sapiens	98-116
15491613-4	2004	beta-galactosidase and its complex with galactose solved by the SIRAS quick cryo-soaking technique at 1.90 A and 2.10 A resolution, respectively.	Galactose	40-49	galactosidase beta 1	Homo sapiens	0-18
15877208-3	2005	The lysosomal enzymes N-acetylgalactosamine-6-sulphate sulphatase and beta-galactosidase involve the stepwise degradation of keratan sulphate (KS).	Keratan Sulfate	125-141	galactosidase beta 1	Homo sapiens	70-88
15877208-3	2005	The lysosomal enzymes N-acetylgalactosamine-6-sulphate sulphatase and beta-galactosidase involve the stepwise degradation of keratan sulphate (KS).	Keratan Sulfate	143-145	galactosidase beta 1	Homo sapiens	70-88
15556773-1	2004	In the course of chemical modification of alpha-fucosidase inhibitors of 5a-carba-fucopyranosylamine type, an N-dodecyl derivative of the enantiomer 6-deoxy-5a-carba-beta-D-galactopyranosylamine demonstrated very strong inhibition of beta-galactosidase and beta-glucosidase.	Nitrogen	110-111	galactosidase beta 1	Homo sapiens	234-252
15556773-1	2004	In the course of chemical modification of alpha-fucosidase inhibitors of 5a-carba-fucopyranosylamine type, an N-dodecyl derivative of the enantiomer 6-deoxy-5a-carba-beta-D-galactopyranosylamine demonstrated very strong inhibition of beta-galactosidase and beta-glucosidase.	n-dodecyl radical	112-119	galactosidase beta 1	Homo sapiens	234-252
15491613-12	2004	beta-galactosidase is a glycoprotein containing seven N-linked oligosaccharide chains and is the only structure of a glycosylated beta-galactosidase described to date.	n-linked oligosaccharide	54-78	galactosidase beta 1	Homo sapiens	0-18
15491613-12	2004	beta-galactosidase is a glycoprotein containing seven N-linked oligosaccharide chains and is the only structure of a glycosylated beta-galactosidase described to date.	n-linked oligosaccharide	54-78	galactosidase beta 1	Homo sapiens	130-148
15546200-3	2004	Fluorophenyl-beta-d-galactopyranosides provide a novel class of NMR active molecules, which are highly responsive to the action of beta-galactosidase (beta-gal), the product of the lacZ gene.	fluorophenyl-beta-d-galactopyranosides	0-38	galactosidase beta 1	Homo sapiens	131-149
15546200-3	2004	Fluorophenyl-beta-d-galactopyranosides provide a novel class of NMR active molecules, which are highly responsive to the action of beta-galactosidase (beta-gal), the product of the lacZ gene.	fluorophenyl-beta-d-galactopyranosides	0-38	galactosidase beta 1	Homo sapiens	131-139
15127211-5	2004	The activity of the soluble lysosomal enzymes cathepsin C and beta-galactosidase in the culture medium was increased upon ionomycin treatment.	Ionomycin	122-131	galactosidase beta 1	Homo sapiens	62-80
15322894-0	2004	Bounded water kinetic model of beta-galactosidase in reverse micelles.	Water	8-13	galactosidase beta 1	Homo sapiens	31-49
15322894-1	2004	In the present investigation, beta-galactosidase was solubilized into Aerosol OT (AOT)/isooctane reverse micelles.	Dioctyl Sulfosuccinic Acid	82-85	galactosidase beta 1	Homo sapiens	30-48
15322894-1	2004	In the present investigation, beta-galactosidase was solubilized into Aerosol OT (AOT)/isooctane reverse micelles.	2,2,4-trimethylpentane	87-96	galactosidase beta 1	Homo sapiens	30-48
15326589-3	2004	Arabinose, which regulates the position of the arm in AraC protein now regulates the availability of the alpha-peptide to alpha-acceptor beta-galactosidase, thereby modulating its activity in response to arabinose.	Arabinose	0-9	galactosidase beta 1	Homo sapiens	137-155
15326589-3	2004	Arabinose, which regulates the position of the arm in AraC protein now regulates the availability of the alpha-peptide to alpha-acceptor beta-galactosidase, thereby modulating its activity in response to arabinose.	Arabinose	204-213	galactosidase beta 1	Homo sapiens	137-155
15355077-3	2004	Particularly, polystyrene-conjugated beta-galactosidase showed a catalytic efficiency that was more than 145 times higher than that of the native enzyme for a transgalactosylation reaction.	Polystyrenes	14-25	galactosidase beta 1	Homo sapiens	37-55
15267233-4	2004	The transfection inhibiting role of the five-carbon spacer unit in the headgroup region of the present novel class of cationic lipids was demonstrated by both beta-galactosidase reporter gene expression and histochemical X-gal staining assays.	Carbon	45-51	galactosidase beta 1	Homo sapiens	159-177
15207696-9	2004	Taking together with results from FACS analysis revealing that more than 90% of CBMN cells were positive for X-gal staining after treatment of C45D18-conjugated beta-galactosidase, we propose that C45D18 translocates bioactive macromolecules directly into the nucleus.	5-bromo-4-chloro-3-indolyl beta-galactoside	109-114	galactosidase beta 1	Homo sapiens	161-179
15506760-0	2004	Tunable reactivation of nanoparticle-inhibited beta-galactosidase by glutathione at intracellular concentrations.	Glutathione	69-80	galactosidase beta 1	Homo sapiens	47-65
15506760-1	2004	Positively charged trimethylammonium-functionalized mixed monolayer protected clusters (MMPCs) of different chain lengths (C(8) and C(11)) have been used to bind beta-galactosidase through complementary electrostatic interactions, resulting in complete enzyme inhibition.	Cetrimonium	19-36	galactosidase beta 1	Homo sapiens	162-180
15456960-6	2004	On average, Lipofectamine 2000 was the most effective nonviral method examined yielding consistently high transfection rates (8.1% beta-galactosidase-positive cells) combined with low toxicity.	Lipofectamine	12-30	galactosidase beta 1	Homo sapiens	131-149
18969385-5	2004	Using the developed method, the enzymatic activities of invertase and beta-galactosidase were determined through their reaction with sucrose and lactose, respectively.	Sucrose	133-140	galactosidase beta 1	Homo sapiens	70-88
15174060-5	2004	Three model proteins with molecular mass ranging from 14 kDa (cytochrome c) to 116 kDa (beta-galactosidase) are stained by Coomassie blue and electrophoretically extracted from gels with protein loadings as low as 50 ng.	Coomassie blue	123-137	galactosidase beta 1	Homo sapiens	88-106
15111593-4	2004	The distribution of beta-galactosidase expression was analyzed in paraffin-embedded sections.	Paraffin	66-74	galactosidase beta 1	Homo sapiens	20-38
15183847-6	2004	This PSK-induced apoptosis was neutralized by the addition of galactose to the culture medium, whereas apoptosis was augmented by treatment with beta-galactosidase, indicating the inhibitory involvement of galactose in the mechanism of action.	Galactose	206-215	galactosidase beta 1	Homo sapiens	145-163
18969385-5	2004	Using the developed method, the enzymatic activities of invertase and beta-galactosidase were determined through their reaction with sucrose and lactose, respectively.	Lactose	145-152	galactosidase beta 1	Homo sapiens	70-88
15056864-1	2004	In the course of our search for natural estrogenic compounds from medicinal plants, we found that the methanolic extract from the roots of Moghania philippinensis (Fabaceae) showed significant effects on the proliferation of MCF-7 cells (human breast cancer) and induction of beta-galactosidase activity in a yeast two-hybrid assay.	methanolic	102-112	galactosidase beta 1	Homo sapiens	276-294
15034616-1	2004	In examining C-6 modified 4-nitrophenyl beta-D-galactopyranosides as donor structures the beta-galactosidase (Bacillus circulans) revealed an unexpectedly broad substrate specificity which allowed successful syntheses of various disaccharide components.	Carbon	13-14	galactosidase beta 1	Homo sapiens	90-108
15034616-1	2004	In examining C-6 modified 4-nitrophenyl beta-D-galactopyranosides as donor structures the beta-galactosidase (Bacillus circulans) revealed an unexpectedly broad substrate specificity which allowed successful syntheses of various disaccharide components.	4-nitrophenylgalactoside	26-65	galactosidase beta 1	Homo sapiens	90-108
15034616-1	2004	In examining C-6 modified 4-nitrophenyl beta-D-galactopyranosides as donor structures the beta-galactosidase (Bacillus circulans) revealed an unexpectedly broad substrate specificity which allowed successful syntheses of various disaccharide components.	Disaccharides	229-241	galactosidase beta 1	Homo sapiens	90-108
15056864-4	2004	Antiestrogenic activities were also examined based on the inhibition of MCF-7 cell proliferation and beta-galactosidase activity in the yeast two-hybrid assay, mediated by 17beta-estradiol.	Estradiol	172-188	galactosidase beta 1	Homo sapiens	101-119
15060622-0	2004	A study of the relationships of interactions between Asp-201, Na+ or K+, and galactosyl C6 hydroxyl and their effects on binding and reactivity of beta-galactosidase.	Aspartic Acid	53-56	galactosidase beta 1	Homo sapiens	147-165
15060622-0	2004	A study of the relationships of interactions between Asp-201, Na+ or K+, and galactosyl C6 hydroxyl and their effects on binding and reactivity of beta-galactosidase.	galactosyl c6 hydroxyl	77-99	galactosidase beta 1	Homo sapiens	147-165
15060622-1	2004	The interactions between Na+ (and K+) and Asp-201 of beta-galactosidase were studied.	Aspartic Acid	42-45	galactosidase beta 1	Homo sapiens	53-71
15060622-17	2004	D201F-beta-galactosidase, with a very bulky hydrophobic side chain in place of Asp, essentially obliterated all binding and catalysis.	Aspartic Acid	79-82	galactosidase beta 1	Homo sapiens	6-24
15090209-5	2004	Here, we describe a cAMP assay based on the enzyme fragmentation complementation (EFC) of beta-galactosidase.	Cyclic AMP	20-24	galactosidase beta 1	Homo sapiens	90-108
15004806-0	2004	Novel NMR approach to assessing gene transfection: 4-fluoro-2-nitrophenyl-beta-D-galactopyranoside as a prototype reporter molecule for beta-galactosidase.	4-fluoro-2-nitrophenyl-beta-d-galactopyranoside	51-98	galactosidase beta 1	Homo sapiens	136-154
15004806-4	2004	4-Fluoro-2-nitrophenyl-beta-D-galactopyranoside (PFONPG) is a novel prototype NMR-sensitive molecule, which is highly responsive to the action of beta-galactosidase (beta-gal), the product of the lacZ gene.	4-fluoro-2-nitrophenyl-beta-d-galactopyranoside	0-47	galactosidase beta 1	Homo sapiens	146-164
15004806-4	2004	4-Fluoro-2-nitrophenyl-beta-D-galactopyranoside (PFONPG) is a novel prototype NMR-sensitive molecule, which is highly responsive to the action of beta-galactosidase (beta-gal), the product of the lacZ gene.	4-fluoro-2-nitrophenyl-beta-d-galactopyranoside	0-47	galactosidase beta 1	Homo sapiens	146-154
15004806-4	2004	4-Fluoro-2-nitrophenyl-beta-D-galactopyranoside (PFONPG) is a novel prototype NMR-sensitive molecule, which is highly responsive to the action of beta-galactosidase (beta-gal), the product of the lacZ gene.	pfonpg	49-55	galactosidase beta 1	Homo sapiens	146-164
15004806-4	2004	4-Fluoro-2-nitrophenyl-beta-D-galactopyranoside (PFONPG) is a novel prototype NMR-sensitive molecule, which is highly responsive to the action of beta-galactosidase (beta-gal), the product of the lacZ gene.	pfonpg	49-55	galactosidase beta 1	Homo sapiens	146-154
14996712-3	2004	Here we show that DDAOG, a conjugate of beta-galactoside and 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO), is not only a chromogenic beta-gal substrate but that the cleavage product has far-red fluorescence properties detectable by imaging.	ddaog	18-23	galactosidase beta 1	Homo sapiens	40-48
14996712-3	2004	Here we show that DDAOG, a conjugate of beta-galactoside and 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO), is not only a chromogenic beta-gal substrate but that the cleavage product has far-red fluorescence properties detectable by imaging.	DDAO	61-114	galactosidase beta 1	Homo sapiens	40-48
14996712-3	2004	Here we show that DDAOG, a conjugate of beta-galactoside and 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO), is not only a chromogenic beta-gal substrate but that the cleavage product has far-red fluorescence properties detectable by imaging.	DDAO	18-22	galactosidase beta 1	Homo sapiens	40-48
14745516-3	2004	We synthesised and purified radioiodine-labelled phenylethyl-beta- d-thiogalactopyranoside (PETG), a competitive inhibitor specific against Escherichia coli beta-galactosidase.	Iodine-131	28-39	galactosidase beta 1	Homo sapiens	157-175
14745516-3	2004	We synthesised and purified radioiodine-labelled phenylethyl-beta- d-thiogalactopyranoside (PETG), a competitive inhibitor specific against Escherichia coli beta-galactosidase.	phenylethyl-beta- d-thiogalactopyranoside	49-90	galactosidase beta 1	Homo sapiens	157-175
14745516-3	2004	We synthesised and purified radioiodine-labelled phenylethyl-beta- d-thiogalactopyranoside (PETG), a competitive inhibitor specific against Escherichia coli beta-galactosidase.	petg	92-96	galactosidase beta 1	Homo sapiens	157-175
14745516-4	2004	We showed that [(125)I]iodo-PETG specifically binds to beta-galactosidase as verified by column chromatography and polyacrylamide gel electrophoresis after incubation of radiotracer with the protein.	iodo-petg	23-32	galactosidase beta 1	Homo sapiens	55-73
14745516-4	2004	We showed that [(125)I]iodo-PETG specifically binds to beta-galactosidase as verified by column chromatography and polyacrylamide gel electrophoresis after incubation of radiotracer with the protein.	polyacrylamide	115-129	galactosidase beta 1	Homo sapiens	55-73
14745516-5	2004	We also showed through enzyme kinetic studies that iodo-PETG retains inhibitory action against beta-galactosidase activity.	iodo-petg	51-60	galactosidase beta 1	Homo sapiens	95-113
14745516-8	2004	These results confirm that radioiodine-labelled PETG specifically targets beta-galactosidase and that its uptake rates faithfully reflect levels of expression of the lacZ reporter gene.	Iodine-131	27-38	galactosidase beta 1	Homo sapiens	74-92
14767868-4	2004	Treatment of these cells with varying concentrations of indomethacin (INDO, 0, 50, 100, and 300 micromol/L) resulted in a dose-dependent decrease in apoAI promoter activity (% acetylation corrected for beta-galactosidase activity: were 46.1 +/- 2.6, 29.9 +/- 1.2, 25.2 +/- 2.9, and 17.2 +/- 2.8, respectively, P &lt;.001).	Indomethacin	56-68	galactosidase beta 1	Homo sapiens	202-220
15009703-7	2004	The effects of ED on melanoma cells were found to be mediated by splicing form of beta-galactosidase (S-Gal) occupancy, as being suppressed by lactose.	Lactose	143-150	galactosidase beta 1	Homo sapiens	82-100
14697524-4	2004	Dose-response curves for 17beta-estradiol (E2) obtained with the beta Gal assay were similar to those reported and the calculated EC(50) of 0.2 nM was even slightly better.	Estradiol	25-41	galactosidase beta 1	Homo sapiens	65-73
14753708-2	2004	When lac-repressor-beta-galactosidase fusion protein is loaded onto a new DNA-Sepharose column, less elutes from a new column than one that has been used two or more times.	Sepharose	78-87	galactosidase beta 1	Homo sapiens	19-37
14717178-6	2003	It was found that 4-chloro-E2 elicited strong estrogenic activity, at almost the same level as that of estrone (EC50 = 10(2) nM), while 2,4-dichloro-E2 elicited weaker beta-galactosidase activity compared with that of 4-chloro-E2.	2,4-dichloro-e2	136-151	galactosidase beta 1	Homo sapiens	168-186
14670055-1	2003	The enzyme beta-galactosidase has been covalently immobilized onto a gold-coated magnetoelastic film via a self-assembled monolayer (SAM) of omega-carboxylic acid alkylthiol.	omega-carboxylic acid alkylthiol	141-173	galactosidase beta 1	Homo sapiens	11-29
14733541-1	2004	The enzyme beta-galactosidase has been immobilized through incorporation into a selectively soluble microgel, prepared from DNA, biotinylated peptide nucleic acid (PNA), and the protein avidin.	Peptides	142-149	galactosidase beta 1	Homo sapiens	11-29
14717178-9	2003	The maximal beta-galactosidase activity for 2,4-dichloro-E1 was lower than that of 2,4-dichloro-E2, while its EC50 was similar to that of 2,4-dichloro-E2.	2,4-dichloro-e1	44-59	galactosidase beta 1	Homo sapiens	12-30
14717178-9	2003	The maximal beta-galactosidase activity for 2,4-dichloro-E1 was lower than that of 2,4-dichloro-E2, while its EC50 was similar to that of 2,4-dichloro-E2.	2,4-dichloro-e2	83-98	galactosidase beta 1	Homo sapiens	12-30
14717178-9	2003	The maximal beta-galactosidase activity for 2,4-dichloro-E1 was lower than that of 2,4-dichloro-E2, while its EC50 was similar to that of 2,4-dichloro-E2.	2,4-dichloro-e2	138-153	galactosidase beta 1	Homo sapiens	12-30
14665375-8	2003	Urinary TBARS and MDA had statistically significant correlations with alphaGST, GAL, NAG, Ca, and oxalate, but had no correlation with piGST, citrate, OPN, Mg, and P. Urinary citrate had a negative, linear, and statistically significant correlation with alphaGST, GAL, and NAG.	Thiobarbituric Acid Reactive Substances	8-13	galactosidase beta 1	Homo sapiens	264-267
14678774-5	2003	When these cells were exposed to 1, 5, or 10 microM glucosylsphingosine for a period of 18 h, they became shriveled, neurite outgrowth was suppressed, and the activities of the lysosomal enzymes glucocerebrosidase, sphingomyelinase, and beta-galactosidase were reduced in a dose-dependent manner.	sphingosyl beta-glucoside	52-71	galactosidase beta 1	Homo sapiens	237-255
14665375-8	2003	Urinary TBARS and MDA had statistically significant correlations with alphaGST, GAL, NAG, Ca, and oxalate, but had no correlation with piGST, citrate, OPN, Mg, and P. Urinary citrate had a negative, linear, and statistically significant correlation with alphaGST, GAL, and NAG.	Thiobarbituric Acid Reactive Substances	8-13	galactosidase beta 1	Homo sapiens	80-83
14577575-1	2003	In this paper we report that 3"-azido-3"-deoxythymidine (AZT) treatment of human erythroleukemia (K562) cells greatly alters the pattern of protein glycans and significantly modifies beta,(1 --&gt; 4)galactosyltransferase, beta-galactosidase, and alpha,(2 --&gt; 8)sialyltransferase activities.	Zidovudine	57-60	galactosidase beta 1	Homo sapiens	223-252
12896982-4	2003	ANS-green fluorescence protein and ANS-beta-galactosidase chimeras were both expressed exclusively in the nucleus, whereas wild-type chimeras or an ACF deletion mutant lacking the ANS were cytoplasmic.	1-anilino-8-naphthalenesulfonate	35-38	galactosidase beta 1	Homo sapiens	39-57
12896982-4	2003	ANS-green fluorescence protein and ANS-beta-galactosidase chimeras were both expressed exclusively in the nucleus, whereas wild-type chimeras or an ACF deletion mutant lacking the ANS were cytoplasmic.	1-anilino-8-naphthalenesulfonate	35-38	galactosidase beta 1	Homo sapiens	39-57
14550747-6	2003	Finally, dioxin decreases SA (senescence associated) beta-galactosidase staining, an indicator of senescence, in the differentiating keratinocytes.	Dioxins	9-15	galactosidase beta 1	Homo sapiens	53-71
14550747-6	2003	Finally, dioxin decreases SA (senescence associated) beta-galactosidase staining, an indicator of senescence, in the differentiating keratinocytes.	sa	26-28	galactosidase beta 1	Homo sapiens	53-71
14551989-3	2003	The estrogenic activity of BPA and its mono- and di-beta-D-glucopyranosides were measured with an enzyme-linked immunosorbent assay (ELISA)-based estrogen receptor competitive binding assay and with a yeast two-hybrid assay adapted to a chemiluminescent reporter gene (for beta-galactosidase).	bisphenol A	27-30	galactosidase beta 1	Homo sapiens	273-291
14616021-3	2003	The nanopipettor was combined with capillary electrophoresis using laser-induced fluorescence detection to monitor a small-scale enzyme reaction (beta-galactosidase) using a tetramethylrhodamine-labeled substrate.	tetramethylrhodamine	174-194	galactosidase beta 1	Homo sapiens	146-164
14505649-1	2003	Chemical modification of 5a-carba-beta-DL-fucopyranosylamine (3) generated six N-substituted derivatives 9a-f, among which N-octyl 9b, decyl 9c, and phenylbutyl ones 9f were found to be very strong beta-galactosidase as well as beta-glucosidase inhibitors.	5a-carba-beta-dl-fucopyranosylamine	25-60	galactosidase beta 1	Homo sapiens	198-216
14505649-3	2003	Therefore, 6-deoxy-5a-carba-beta-D-galactopyranosylamine (D-3) might be a promising lead compound for further design of new carba sugar-type beta-galactosidase inhibitors.	Cholecalciferol	58-61	galactosidase beta 1	Homo sapiens	141-159
14577575-1	2003	In this paper we report that 3"-azido-3"-deoxythymidine (AZT) treatment of human erythroleukemia (K562) cells greatly alters the pattern of protein glycans and significantly modifies beta,(1 --&gt; 4)galactosyltransferase, beta-galactosidase, and alpha,(2 --&gt; 8)sialyltransferase activities.	Zidovudine	29-55	galactosidase beta 1	Homo sapiens	223-252
12918048-5	2003	Maximal beta-galactosidase expression was observed on day 1, followed by a rapid decrease that continued up to 1 month for a styrenated gelatin gel prepared with a low styrenated gelatin concentration and a low CQ concentration.	camphorquinone	211-213	galactosidase beta 1	Homo sapiens	8-26
12907950-3	2003	The lacZ gene contains a G to A nucleotide change, (Glu to Lys mutation) that abrogates beta-galactosidase activity.	Glutamic Acid	52-55	galactosidase beta 1	Homo sapiens	88-106
12907950-3	2003	The lacZ gene contains a G to A nucleotide change, (Glu to Lys mutation) that abrogates beta-galactosidase activity.	Lysine	59-62	galactosidase beta 1	Homo sapiens	88-106
12918048-6	2003	Dose-dependent reduced expression of beta-galactosidase activity with increasing CQ under photoirradiation was observed.	camphorquinone	81-83	galactosidase beta 1	Homo sapiens	37-55
12877804-4	2003	Meanwhile, LY294002 contributed to apoptosis, caused 2BS cell growth arrest, and activated senescence association beta-galactosidase (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	galactosidase beta 1	Homo sapiens	114-132
12915210-9	2003	These results support the hypothesis that, during fibroblast aging, the increase of autophagic vacuoles, as well as that of beta-galactosidase activity, may be associated to an increase of lysosomal mass and to an accumulation of degradative autolysosomes with lipofuscin.	Lipofuscin	261-271	galactosidase beta 1	Homo sapiens	124-142
12818818-0	2003	Compression behaviour of the enzyme beta-galactosidase and its mixture with microcrystalline cellulose.	microcrystalline cellulose	76-102	galactosidase beta 1	Homo sapiens	36-54
12818818-4	2003	Microcrystalline cellulose is known as a model substance for plastic powders, the used beta-galactosidase was found to be a brittle substance.	microcrystalline cellulose	0-26	galactosidase beta 1	Homo sapiens	87-105
12872989-5	2003	Tissue transglutaminase (tTGase) and beta-galactosidase (pIs, 5.1 and 5.3, respectively) were preferentially bound to the positively charged PDDA surface, whereas lysozyme (pI, 11.0) was selectively bound to the negatively charged PSS surface.	Monothiopyrophosphoric acid	57-60	galactosidase beta 1	Homo sapiens	37-55
12872989-5	2003	Tissue transglutaminase (tTGase) and beta-galactosidase (pIs, 5.1 and 5.3, respectively) were preferentially bound to the positively charged PDDA surface, whereas lysozyme (pI, 11.0) was selectively bound to the negatively charged PSS surface.	styrenesulfonic acid polymer	231-234	galactosidase beta 1	Homo sapiens	37-55
12721802-5	2003	Its sensitivity to endo-beta-galactosidase digestion indicates that poly-N-acetyllactosamine is present on the individually-expressed protein, but not on the authentic GP(5) anchored into the virion envelope.	poly-N-acetyllactosamine	68-92	galactosidase beta 1	Homo sapiens	24-42
12751628-5	2003	A model plasmid DNA, pSV-beta-Gal containing a reporter gene for beta-galactosidase was carried by the nanoemulsion/poly-L-lysine particles.	Lysine	116-129	galactosidase beta 1	Homo sapiens	65-83
12621071-9	2003	Treatment with UV light and heat shock resulted in a small increase in beta-galactosidase activity from one promoter, while treatment with tetradecanoylphorbol 13-acetate resulted in small increases in beta-galactosidase activity from both promoters.	tetradecanoylphorbol 13-acetate	139-170	galactosidase beta 1	Homo sapiens	202-220
12713034-4	2003	Beta-galactosidase (beta-Gal) was chosen as a model enzyme for these studies and was used to convert the substrate fluorescein mono-beta-D-galactopyranoside (FMG) into fluorescein.	fluorescein monogalactoside	115-156	galactosidase beta 1	Homo sapiens	0-18
12713034-4	2003	Beta-galactosidase (beta-Gal) was chosen as a model enzyme for these studies and was used to convert the substrate fluorescein mono-beta-D-galactopyranoside (FMG) into fluorescein.	fluorescein monogalactoside	115-156	galactosidase beta 1	Homo sapiens	20-28
12713034-4	2003	Beta-galactosidase (beta-Gal) was chosen as a model enzyme for these studies and was used to convert the substrate fluorescein mono-beta-D-galactopyranoside (FMG) into fluorescein.	fmg	158-161	galactosidase beta 1	Homo sapiens	0-18
12713034-4	2003	Beta-galactosidase (beta-Gal) was chosen as a model enzyme for these studies and was used to convert the substrate fluorescein mono-beta-D-galactopyranoside (FMG) into fluorescein.	fmg	158-161	galactosidase beta 1	Homo sapiens	20-28
12713034-4	2003	Beta-galactosidase (beta-Gal) was chosen as a model enzyme for these studies and was used to convert the substrate fluorescein mono-beta-D-galactopyranoside (FMG) into fluorescein.	Fluorescein	115-126	galactosidase beta 1	Homo sapiens	0-18
12713034-4	2003	Beta-galactosidase (beta-Gal) was chosen as a model enzyme for these studies and was used to convert the substrate fluorescein mono-beta-D-galactopyranoside (FMG) into fluorescein.	Fluorescein	115-126	galactosidase beta 1	Homo sapiens	20-28
12770766-3	2003	Then, in a one-pot reaction employing beta-galactosidase and core-2 beta6-N-acetylglucosaminyltransferase the core-2 O-glycan structure was prepared.	o-glycan	117-125	galactosidase beta 1	Homo sapiens	38-56
12554371-1	2003	Microcapsules containing beta-galactosidase (lactase) were prepared by solvent evaporation using the pH sensitive polymer, Eudragit L-100.	Polymers	114-121	galactosidase beta 1	Homo sapiens	25-43
12554371-1	2003	Microcapsules containing beta-galactosidase (lactase) were prepared by solvent evaporation using the pH sensitive polymer, Eudragit L-100.	l-100	132-137	galactosidase beta 1	Homo sapiens	25-43
12504378-1	2003	A potent inhibitor of beta-galactosidase (EC 3.2.1.23), 2-phenylethyl 1-thio-beta-D-galactopyranoside (PETG), was radioiodinated for noninvasive imaging of LacZ gene expression.	2-Phenylethyl 1-Thio-Beta-D-Galactopyranoside	56-101	galactosidase beta 1	Homo sapiens	22-40
12852088-4	2003	RESULTS: Cultured human IPE cells stained positively anticytokeratin, The titer of rAAV-LacZ was 2.1 x 10(8) virus particles/ml, 42% cultured human IPE cells expressed beta-galactosidase 7 days after transfection and 67% after 14 days.	ipe	24-27	galactosidase beta 1	Homo sapiens	168-186
12445450-6	2003	Because the assay for lactose measured glucose subsequent to the hydrolysis of lactose by beta-galactosidase, the same degree of precision was observed in lactose.	Lactose	79-86	galactosidase beta 1	Homo sapiens	90-108
12445450-6	2003	Because the assay for lactose measured glucose subsequent to the hydrolysis of lactose by beta-galactosidase, the same degree of precision was observed in lactose.	Lactose	79-86	galactosidase beta 1	Homo sapiens	90-108
12559848-7	2003	The mutant beta-Gal activities were inhibited by Galbeta1-3GalNAc and Galbeta1-4GlcNAc in a concentration-dependent manner.	N-Acetyl-D-lactosamine	70-86	galactosidase beta 1	Homo sapiens	11-19
12652592-7	2003	Enzyme kinetics and inhibition of the beta-galactosidase using FMG and 2-phenylethyl beta-D-thiogalactoside, respectively, were also studied with microchip electrophoresis.	fmg	63-66	galactosidase beta 1	Homo sapiens	38-56
12652592-7	2003	Enzyme kinetics and inhibition of the beta-galactosidase using FMG and 2-phenylethyl beta-D-thiogalactoside, respectively, were also studied with microchip electrophoresis.	2-Phenylethyl 1-Thio-Beta-D-Galactopyranoside	71-107	galactosidase beta 1	Homo sapiens	38-56
12467649-9	2003	We then determined that beta-galactosidase expression was dependent upon the dose of ponasterone A and duration of exposure to inducer.	ponasterone A	85-98	galactosidase beta 1	Homo sapiens	24-42
12467926-5	2003	The bound antibody complexes with the analyte and the labelled analyte were trapped in a protein G column, while the unbound free labelled analyte was eluted and detected colorimetrically down-stream, after reaction with chlorophenolic red-beta-D-galactopyranoside as a substrate for the beta-GAL enzyme.	chlorophenolic red-beta-d-galactopyranoside	221-264	galactosidase beta 1	Homo sapiens	288-296
12392953-6	2002	The bioelectrocatalytic properties of this biosensor offer an additional amplification and thus allow a very sensitive quantification of 4-aminophenol, generated by the beta-galactosidase.	4-aminophenol	137-150	galactosidase beta 1	Homo sapiens	169-187
14599348-4	2002	In the present study, staurosporine, a potent, nonselective kinase inhibitor, was chemically conjugated to a small fragment of beta-galactosidase (termed ED-SS).	Staurosporine	22-35	galactosidase beta 1	Homo sapiens	127-145
12417103-4	2002	beta-galactosidase acts on the substrate 4-methylumbelliferyl-galactoside (MUG) to produce 4-methylumbelliferone (4-MU), detected fluorimetrically with excitation wavelength 355 nm and emission wavelength 460 nm.	4-methylumbelliferyl-galactoside	41-73	galactosidase beta 1	Homo sapiens	0-18
12417103-4	2002	beta-galactosidase acts on the substrate 4-methylumbelliferyl-galactoside (MUG) to produce 4-methylumbelliferone (4-MU), detected fluorimetrically with excitation wavelength 355 nm and emission wavelength 460 nm.	Hymecromone	91-112	galactosidase beta 1	Homo sapiens	0-18
12417103-4	2002	beta-galactosidase acts on the substrate 4-methylumbelliferyl-galactoside (MUG) to produce 4-methylumbelliferone (4-MU), detected fluorimetrically with excitation wavelength 355 nm and emission wavelength 460 nm.	Hymecromone	114-118	galactosidase beta 1	Homo sapiens	0-18
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	Cyclic AMP	11-15	galactosidase beta 1	Homo sapiens	27-45
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	Cyclic AMP	11-15	galactosidase beta 1	Homo sapiens	27-35
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	Cyclic AMP	11-15	galactosidase beta 1	Homo sapiens	47-55
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	Cyclic AMP	11-15	galactosidase beta 1	Homo sapiens	47-55
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	Cyclic AMP	72-76	galactosidase beta 1	Homo sapiens	27-45
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	Cyclic AMP	72-76	galactosidase beta 1	Homo sapiens	27-35
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	Cyclic AMP	72-76	galactosidase beta 1	Homo sapiens	47-55
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	Cyclic AMP	72-76	galactosidase beta 1	Homo sapiens	47-55
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	ed-camp	78-85	galactosidase beta 1	Homo sapiens	27-45
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	ed-camp	78-85	galactosidase beta 1	Homo sapiens	27-35
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	ed-camp	78-85	galactosidase beta 1	Homo sapiens	47-55
14599349-4	2002	In the EFC-cAMP assay, the beta-galactosidase (beta-gal) donor fragment-cAMP (ED-cAMP) conjugate complements with the beta-gal enzyme acceptor (EA) fragment to form an active beta-gal enzyme.	ed-camp	78-85	galactosidase beta 1	Homo sapiens	47-55
12427304-7	2002	By using the beta-galactosidase reporter vector, H5.CMV-lacZ, the purity of the product is improved compared to the same vector purified by 2x CsCl or anion-exchange alone as determined by high-performance liquid chromatography (HPLC), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE; silver stain), Western analysis, electron microscopy, and particle:infectious (VP:IU) unit ratio.	Sodium Dodecyl Sulfate	236-258	galactosidase beta 1	Homo sapiens	13-31
12427304-7	2002	By using the beta-galactosidase reporter vector, H5.CMV-lacZ, the purity of the product is improved compared to the same vector purified by 2x CsCl or anion-exchange alone as determined by high-performance liquid chromatography (HPLC), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE; silver stain), Western analysis, electron microscopy, and particle:infectious (VP:IU) unit ratio.	polyacrylamide	259-273	galactosidase beta 1	Homo sapiens	13-31
12427304-7	2002	By using the beta-galactosidase reporter vector, H5.CMV-lacZ, the purity of the product is improved compared to the same vector purified by 2x CsCl or anion-exchange alone as determined by high-performance liquid chromatography (HPLC), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE; silver stain), Western analysis, electron microscopy, and particle:infectious (VP:IU) unit ratio.	Sodium Dodecyl Sulfate	295-298	galactosidase beta 1	Homo sapiens	13-31
12427304-7	2002	By using the beta-galactosidase reporter vector, H5.CMV-lacZ, the purity of the product is improved compared to the same vector purified by 2x CsCl or anion-exchange alone as determined by high-performance liquid chromatography (HPLC), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE; silver stain), Western analysis, electron microscopy, and particle:infectious (VP:IU) unit ratio.	Silver	305-311	galactosidase beta 1	Homo sapiens	13-31
12519628-2	2002	The plasmid DNA that contained the Escherichia coli beta-galactosidase reporter gene was condensed using poly-l-lysine of molecular mass 20,700 (PLK99) to form a polyplex which was interacted with several anionic liposome formulations to form lipopolyplexes.	Lysine	105-118	galactosidase beta 1	Homo sapiens	52-70
12519628-9	2002	The lipopolyplexes with lipid composition DOPE/cholesterol/OA/DSPE-PEG2000 anti-CD3+ PLK99-plasmid DNA had significant gene transfer activity, as monitored by beta-galactosidase expression, that depended on the charge ratio of the component polyplex and the lipid/DNA weight ratio.	Cholesterol	47-58	galactosidase beta 1	Homo sapiens	159-177
12430595-2	2002	Two encoding enzymes, alkaline phosphatase and beta-galactosidase, are used to differentiate the signals of two DNA targets in connection to chronopotentiometric measurements of their electroactive phenol and alpha-naphthol products.	Phenol	198-204	galactosidase beta 1	Homo sapiens	47-65
12414652-8	2002	The biological significance of these results was established by showing that block of p300 activity by overexpression of DN p300 or by Lys-CoA, a specific chemical inhibitor of p300, resulted in growth inhibition, down-regulation of cyclin E, and activation of the senescence-associated beta-galactosidase marker in human melanocytes and melanoma cells.	lys-coa	135-142	galactosidase beta 1	Homo sapiens	287-305
12430595-2	2002	Two encoding enzymes, alkaline phosphatase and beta-galactosidase, are used to differentiate the signals of two DNA targets in connection to chronopotentiometric measurements of their electroactive phenol and alpha-naphthol products.	1-naphthol	209-223	galactosidase beta 1	Homo sapiens	47-65
12101184-3	2002	Cells acutely exposed to adriamycin exhibited an increase in p53 activity, a decline in telomerase activity, and a dramatic increase in beta-galactosidase, a marker of senescence.	Doxorubicin	25-35	galactosidase beta 1	Homo sapiens	136-154
12364575-7	2002	Paraformaldehyde and formaldehyde were effective as fixatives only at 4C for a period of less than 4 hr, and Carnoy"s solution destroyed beta-Gal activity.	Carnoy's solution	109-126	galactosidase beta 1	Homo sapiens	137-145
12161128-0	2002	Synthesis of [(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-5-methylfuran-4-carboxylic acid derivatives: new leads as selective beta-galactosidase inhibitors.	[(2s,3s,4r)-3,4-dihydroxypyrrolidin-2-yl]-5-methylfuran-4-carboxylic acid	13-86	galactosidase beta 1	Homo sapiens	123-141
12238777-8	2002	High-level rAAV-mediated beta-galactosidase expression was achieved in HeLa cells from CAG, CMV, RSV and SV40 promoters, respectively, but notfrom the CK6 promoter.	raav	11-15	galactosidase beta 1	Homo sapiens	25-43
11900490-3	2002	We herein report that PUVA-induced growth arrest, the senescent phenotype with long-term induction of senescence-associated beta-galactosidase, as well as increased expression of matrix metalloprotease-1 are fully reversible at days 100 to 130 post PUVA treatment in four independently tested fibroblast strains.	puva	22-26	galactosidase beta 1	Homo sapiens	124-142
12051701-4	2002	Exposure of pyruvate treated cells to the antioxidant and glutathione precursor N-acetylcysteine restores cell growth and reverses the increase in senescence-associated beta-galactosidase activity.	Pyruvic Acid	12-20	galactosidase beta 1	Homo sapiens	169-187
12051701-4	2002	Exposure of pyruvate treated cells to the antioxidant and glutathione precursor N-acetylcysteine restores cell growth and reverses the increase in senescence-associated beta-galactosidase activity.	Glutathione	58-69	galactosidase beta 1	Homo sapiens	169-187
12051701-4	2002	Exposure of pyruvate treated cells to the antioxidant and glutathione precursor N-acetylcysteine restores cell growth and reverses the increase in senescence-associated beta-galactosidase activity.	Acetylcysteine	80-96	galactosidase beta 1	Homo sapiens	169-187
12112318-3	2002	The addition of ZnCl(2) to HT29-APC cells increased wild-type APC protein and Mad1 RNA and protein and decreased levels of c-myc and ODC RNA and protein, relative to these parameters in HT29 cells transfected with the same plasmid containing the beta-galactosidase gene in place of APC.	zncl	16-20	galactosidase beta 1	Homo sapiens	246-264
12270661-4	2002	The assay was carried out in 96-well plates and the unneutralized virus was quantitated by spectrophotometric measurement of the beta-galactosidase enzymatic reaction following incubation of the infected cell lysate with the enzyme substrate, chlorophenol red beta-D-galactopyranoside (CPRG).	chlorophenol red galactopyranoside	243-284	galactosidase beta 1	Homo sapiens	129-147
12195949-4	2002	The beta-galactosidase label hydrolyses the substrate aminophenyl-beta-galactopyranoside, and the generated aminophenol enters then into a bioelectrocatalytic amplification cycle at the GDH biosensor.	aminophenyl-beta-galactopyranoside	54-88	galactosidase beta 1	Homo sapiens	4-22
12195949-4	2002	The beta-galactosidase label hydrolyses the substrate aminophenyl-beta-galactopyranoside, and the generated aminophenol enters then into a bioelectrocatalytic amplification cycle at the GDH biosensor.	Aminophenols	108-119	galactosidase beta 1	Homo sapiens	4-22
12180905-3	2002	These columns were used to measure the specific interactions between the bound beta-galactosidase and a library of modified beta-galactopyranosides using electrospray mass spectrometry as the means of detection.	beta-galactopyranosides	124-147	galactosidase beta 1	Homo sapiens	79-97
12080380-4	2002	When luciferase and beta-galactosidase genes were used as reporter genes, O-Chol showed better efficiency than other commercial transfection reagents such as lipofectin, lipofectAMINE, DC-Chol, and FuGENE 6, both in vitro and in vivo.	o-chol	74-80	galactosidase beta 1	Homo sapiens	20-38
12146464-3	2002	With the multianalyte sensor it was possible to detect glucose and galactose by sequential injection of their corresponding oxidase enzymes: glucose oxidase and galactose oxidase, while lactose was determined by injection of a mixture of beta-galactosidase and glucose oxidase enzymes.	Glucose	55-62	galactosidase beta 1	Homo sapiens	238-256
12146464-3	2002	With the multianalyte sensor it was possible to detect glucose and galactose by sequential injection of their corresponding oxidase enzymes: glucose oxidase and galactose oxidase, while lactose was determined by injection of a mixture of beta-galactosidase and glucose oxidase enzymes.	Lactose	69-76	galactosidase beta 1	Homo sapiens	238-256
11971989-8	2002	Small increases in beta-galactosidase activity were observed with both L1Hs promoters after treatment with serum, testosterone, dihydrotestosterone and organochloride pesticides, indicating that these agents can influence L1Hs transcription.	Testosterone	114-126	galactosidase beta 1	Homo sapiens	19-37
11971989-8	2002	Small increases in beta-galactosidase activity were observed with both L1Hs promoters after treatment with serum, testosterone, dihydrotestosterone and organochloride pesticides, indicating that these agents can influence L1Hs transcription.	Dihydrotestosterone	128-147	galactosidase beta 1	Homo sapiens	19-37
11971989-8	2002	Small increases in beta-galactosidase activity were observed with both L1Hs promoters after treatment with serum, testosterone, dihydrotestosterone and organochloride pesticides, indicating that these agents can influence L1Hs transcription.	organochloride	152-166	galactosidase beta 1	Homo sapiens	19-37
11959797-15	2002	Streptavidin with a single molecule of DNA-biotin bound was used to tag biotinylated beta-galactosidase, a model multimeric enzyme.	Biotin	43-49	galactosidase beta 1	Homo sapiens	85-103
11814461-0	2002	Residual galactosylsphingosine (psychosine) beta-galactosidase activities and associated GALC mutations in late and very late onset Krabbe disease.	Psychosine	9-30	galactosidase beta 1	Homo sapiens	44-62
11911659-0	2002	Bacterium-based heavy metal biosorbents: enhanced uptake of cadmium by E. coli expressing a metallothionein fused to beta-galactosidase.	Metals	22-27	galactosidase beta 1	Homo sapiens	117-135
11911659-0	2002	Bacterium-based heavy metal biosorbents: enhanced uptake of cadmium by E. coli expressing a metallothionein fused to beta-galactosidase.	Cadmium	60-67	galactosidase beta 1	Homo sapiens	117-135
11792172-1	2002	Mixed monolayer protected gold clusters (MMPCs) functionalized with quaternary ammonium chains efficiently transfect mammalian cell cultures, as determined through beta-galactosidase transfer and activity.	quaternary ammonium	68-87	galactosidase beta 1	Homo sapiens	164-182
11844492-2	2002	Thus, methyl alpha-D-galactopyranosyl-(1--&gt;3)-alpha-D-galactopyranoside (3a) produced by reaction of alpha-D-galactopyranosyl fluoride 1 with methyl alpha-D-galactopyranoside (2) is obtained with 51% yield in ice while only 29% is synthesized at 37 degrees C. This result, already previously found by others with proteases and by us with a beta-galactosidase appears to be a general property of hydrolases.	methyl alpha-d-galactopyranosyl-(1--&gt;3)-alpha-d-galactopyranoside	6-74	galactosidase beta 1	Homo sapiens	343-361
11844492-2	2002	Thus, methyl alpha-D-galactopyranosyl-(1--&gt;3)-alpha-D-galactopyranoside (3a) produced by reaction of alpha-D-galactopyranosyl fluoride 1 with methyl alpha-D-galactopyranoside (2) is obtained with 51% yield in ice while only 29% is synthesized at 37 degrees C. This result, already previously found by others with proteases and by us with a beta-galactosidase appears to be a general property of hydrolases.	galactopyranosyl fluoride	104-137	galactosidase beta 1	Homo sapiens	343-361
11844492-2	2002	Thus, methyl alpha-D-galactopyranosyl-(1--&gt;3)-alpha-D-galactopyranoside (3a) produced by reaction of alpha-D-galactopyranosyl fluoride 1 with methyl alpha-D-galactopyranoside (2) is obtained with 51% yield in ice while only 29% is synthesized at 37 degrees C. This result, already previously found by others with proteases and by us with a beta-galactosidase appears to be a general property of hydrolases.	methyl-galactopyranoside	145-177	galactosidase beta 1	Homo sapiens	343-361
11874116-1	2002	Coimmobilization of beta-galactosidase and glucose oxidase in a redox polymer, polyvinylferrocenium perchlorate (PVF+ ClO4-), led to the development of an enzyme electrode for the determination of lactose.	polyvinylferrocenium	79-111	galactosidase beta 1	Homo sapiens	20-38
11874116-1	2002	Coimmobilization of beta-galactosidase and glucose oxidase in a redox polymer, polyvinylferrocenium perchlorate (PVF+ ClO4-), led to the development of an enzyme electrode for the determination of lactose.	polyvinyl fluoride	113-116	galactosidase beta 1	Homo sapiens	20-38
11874116-1	2002	Coimmobilization of beta-galactosidase and glucose oxidase in a redox polymer, polyvinylferrocenium perchlorate (PVF+ ClO4-), led to the development of an enzyme electrode for the determination of lactose.	perchlorate	118-123	galactosidase beta 1	Homo sapiens	20-38
11874116-1	2002	Coimmobilization of beta-galactosidase and glucose oxidase in a redox polymer, polyvinylferrocenium perchlorate (PVF+ ClO4-), led to the development of an enzyme electrode for the determination of lactose.	Lactose	197-204	galactosidase beta 1	Homo sapiens	20-38
11818519-9	2002	Transfection studies revealed that in the presence of 100 nmol/l estradiol-17 beta (E(2)), a minimal 0.3 kb promoter construct (pH-298/+25 beta Gal) mediated a high level of beta-Gal expression in immortalized human oviductal epithelial OE-E6/E7 cells, but not in MCF-7 and CHO-K1 cells.	Estradiol	65-82	galactosidase beta 1	Homo sapiens	174-182
11852701-6	2002	Of all the conjugates tested, basic fuchsin-modified alginate produced the greatest increase in the transfection of a plasmid coding for beta-galactosidase into HeLa cells.	Alginates	53-61	galactosidase beta 1	Homo sapiens	137-155
11786040-7	2002	In animals receiving either vector alone or vector with perflubron, in situ beta-galactosidase expression was observed in a variety of cells including large airway, bronchiolar, and alveolar epithelial cells.	perflubron	56-66	galactosidase beta 1	Homo sapiens	76-94
11684050-8	2001	These enhancing effects of APP on the glutamate-induced vulnerability in hippocampal neurons and the glutamate (NMDA)-dependent survival in cerebellar neurons were blocked by glutamate receptor inhibitors, and were not seen after application of a control adenovirus carrying cDNA of beta-galactosidase.	N-Methylaspartate	112-116	galactosidase beta 1	Homo sapiens	283-301
11689613-4	2001	When tested in an RSV minigenome replicon system using beta-galactosidase as a reporter gene, C7G, C15G, and C21G located in the Cys(3)-His(1) motif showed a significant reduction in processive RNA synthesis compared to wild-type (wt) M2-1.	Cysteine	129-132	galactosidase beta 1	Homo sapiens	55-73
11689613-4	2001	When tested in an RSV minigenome replicon system using beta-galactosidase as a reporter gene, C7G, C15G, and C21G located in the Cys(3)-His(1) motif showed a significant reduction in processive RNA synthesis compared to wild-type (wt) M2-1.	Histidine	136-139	galactosidase beta 1	Homo sapiens	55-73
11675146-3	2001	A novel, non-nucleoside inhibitor of HCMV replication, PD0084430, was identified in a screening assay using the HCMV beta-galactosidase recombinant RC256.	PD 0084430	55-64	galactosidase beta 1	Homo sapiens	117-135
11814060-2	2001	Here we report that nicotinamide (NAA) can induce rapid and reversible reversion of aging phenotypes in human diploid fibroblasts in terms of cell morphology and senescence-associated beta-galactosidase activity.	Niacinamide	20-32	galactosidase beta 1	Homo sapiens	184-202
11814060-2	2001	Here we report that nicotinamide (NAA) can induce rapid and reversible reversion of aging phenotypes in human diploid fibroblasts in terms of cell morphology and senescence-associated beta-galactosidase activity.	1-naphthaleneacetic acid	34-37	galactosidase beta 1	Homo sapiens	184-202
11851821-2	2001	This galactoside is utilized as a substrate for the detection of the beta-galactosidase activity of coliform bacteria in water analysis.	Galactosides	5-16	galactosidase beta 1	Homo sapiens	69-87
11851821-2	2001	This galactoside is utilized as a substrate for the detection of the beta-galactosidase activity of coliform bacteria in water analysis.	Water	121-126	galactosidase beta 1	Homo sapiens	69-87
12549215-5	2001	It has been reported that the C6 ceramide can induce senescence of WI-38 HDF and promote the activity of beta-galactosidase, but, C2 ceramide has no such effect.	Ceramides	33-41	galactosidase beta 1	Homo sapiens	105-123
12549215-7	2001	10 mumol/ml of C6 ceramide treatment for more than 72 hours can induce morphological alterations (such as: enlarged, flattened and irregular cell body), cell cycle arrested at G1 phase and the expression of the senescent histochemical marker-beta-galactosidase in HUVECs.	Ceramides	18-26	galactosidase beta 1	Homo sapiens	242-260
11811064-2	2001	Octyl beta-D-galactopyranoside and octyl beta-D-glucopyranoside were synthesized from the corresponding sugars (lactose or glucose) and octyl alcohol under catalysis with glycolytic enzymes, beta-galactosidase and beta-glucosidase, respectively.	octyl galactopyranoside	0-30	galactosidase beta 1	Homo sapiens	191-209
11689267-6	2001	Finally the ability of the PAHy-GTA(b) derivative to mediate the transfection of HepG2 cells using the marker gene beta-galactosidase was studied.	pahy-gta	27-35	galactosidase beta 1	Homo sapiens	115-133
11701079-1	2001	BACKGROUND: Ganglioside G(M1) is a membrane glycolipid typical of nerve cell membranes, where it partakes in neurotransmitter release and is catabolized by the lysosomal beta-galactosidase (GM1ase) (EC 3.2.1.23).	Gangliosides	12-23	galactosidase beta 1	Homo sapiens	170-188
11701079-1	2001	BACKGROUND: Ganglioside G(M1) is a membrane glycolipid typical of nerve cell membranes, where it partakes in neurotransmitter release and is catabolized by the lysosomal beta-galactosidase (GM1ase) (EC 3.2.1.23).	Glycolipids	44-54	galactosidase beta 1	Homo sapiens	170-188
11811064-2	2001	Octyl beta-D-galactopyranoside and octyl beta-D-glucopyranoside were synthesized from the corresponding sugars (lactose or glucose) and octyl alcohol under catalysis with glycolytic enzymes, beta-galactosidase and beta-glucosidase, respectively.	octyl-beta-D-glucoside	35-63	galactosidase beta 1	Homo sapiens	191-209
11811064-2	2001	Octyl beta-D-galactopyranoside and octyl beta-D-glucopyranoside were synthesized from the corresponding sugars (lactose or glucose) and octyl alcohol under catalysis with glycolytic enzymes, beta-galactosidase and beta-glucosidase, respectively.	Sugars	104-110	galactosidase beta 1	Homo sapiens	191-209
11811064-2	2001	Octyl beta-D-galactopyranoside and octyl beta-D-glucopyranoside were synthesized from the corresponding sugars (lactose or glucose) and octyl alcohol under catalysis with glycolytic enzymes, beta-galactosidase and beta-glucosidase, respectively.	Octanols	136-149	galactosidase beta 1	Homo sapiens	191-209
11504597-0	2001	Galactonojirimycin derivatives restore mutant human beta-galactosidase activities expressed in fibroblasts from enzyme-deficient knockout mouse.	galactonojirimycin	0-18	galactosidase beta 1	Homo sapiens	52-70
11602356-3	2001	beta-Galactosidase could be induced over 300 fold with this system, and the extent of induction could be varied depending upon the amount of tetracycline added.	Tetracycline	141-153	galactosidase beta 1	Homo sapiens	0-18
12386455-3	2001	In this study, we have used fast atom bombardment mass spectrometry (FAB-MS) to examine terminal sequences released by endo-beta-galactosidase from O-glycans obtained by reductive elimination of bronchial mucins purified from the sputum of 8 CF and 8 CB patients.	o-glycans	148-157	galactosidase beta 1	Homo sapiens	124-142
11559825-8	2001	High salt extraction, in vitro transcription and translation, and posttranslational membrane binding analyses indicated that the beta-galactosidase/LLP fusion proteins were inserted into membranes via the LLP sequences.	Salts	5-9	galactosidase beta 1	Homo sapiens	129-147
11447231-6	2001	First, intracellular beta-galactosidase activity was clearly demonstrated within X-gal-stained cells after TFA-DODAPL:DOPE-mediated delivery of the enzyme.	tfa-dodapl	107-117	galactosidase beta 1	Homo sapiens	21-39
11447231-6	2001	First, intracellular beta-galactosidase activity was clearly demonstrated within X-gal-stained cells after TFA-DODAPL:DOPE-mediated delivery of the enzyme.	dioleoyl phosphatidylethanolamine	118-122	galactosidase beta 1	Homo sapiens	21-39
11745778-2	2001	Previous reports indicate significantly more inactivation and secondary structural perturbation of monomeric and tetrameric beta-galactosidase (beta-gal) during freeze-thawing in sodium phosphate (NaP) buffer as compared with potassium phosphate (KP) buffer.	sodium phosphate	179-195	galactosidase beta 1	Homo sapiens	124-142
11745778-2	2001	Previous reports indicate significantly more inactivation and secondary structural perturbation of monomeric and tetrameric beta-galactosidase (beta-gal) during freeze-thawing in sodium phosphate (NaP) buffer as compared with potassium phosphate (KP) buffer.	sodium phosphate	179-195	galactosidase beta 1	Homo sapiens	124-132
11745778-2	2001	Previous reports indicate significantly more inactivation and secondary structural perturbation of monomeric and tetrameric beta-galactosidase (beta-gal) during freeze-thawing in sodium phosphate (NaP) buffer as compared with potassium phosphate (KP) buffer.	N-(4-aminophenethyl)spiroperidol	197-200	galactosidase beta 1	Homo sapiens	124-142
11745778-2	2001	Previous reports indicate significantly more inactivation and secondary structural perturbation of monomeric and tetrameric beta-galactosidase (beta-gal) during freeze-thawing in sodium phosphate (NaP) buffer as compared with potassium phosphate (KP) buffer.	N-(4-aminophenethyl)spiroperidol	197-200	galactosidase beta 1	Homo sapiens	124-132
11745778-11	2001	However, sucrose, which hydrogen bonds to dried protein in the place of lost water, greatly reduced freezing- and drying-induced denaturation, as observed by the high retention of native protein in the dried state as well as the complete recovery of active beta-gal on reconstitution.	Sucrose	9-16	galactosidase beta 1	Homo sapiens	257-265
11504597-1	2001	Ten low molecular compounds analogous to galactose were screened for inhibition of human beta-galactosidase activity.	Galactose	41-50	galactosidase beta 1	Homo sapiens	89-107
11511921-8	2001	Our results confirm the high impact of Trp 273 for the function of beta-galactosidase and the expression of the Morquio B phenotype.	Tryptophan	39-42	galactosidase beta 1	Homo sapiens	67-85
11521863-12	2001	Enzyme activity of immobilized beta-galactosidase (beta-Gal) was monitored by following the hydrolysis of fluorescein mono-beta-D-galactopyranoside to fluorescein with laser-induced fluorescence.	fluorescein monogalactoside	106-147	galactosidase beta 1	Homo sapiens	31-49
11521863-12	2001	Enzyme activity of immobilized beta-galactosidase (beta-Gal) was monitored by following the hydrolysis of fluorescein mono-beta-D-galactopyranoside to fluorescein with laser-induced fluorescence.	fluorescein monogalactoside	106-147	galactosidase beta 1	Homo sapiens	51-59
11521863-12	2001	Enzyme activity of immobilized beta-galactosidase (beta-Gal) was monitored by following the hydrolysis of fluorescein mono-beta-D-galactopyranoside to fluorescein with laser-induced fluorescence.	Fluorescein	106-117	galactosidase beta 1	Homo sapiens	31-49
11521863-12	2001	Enzyme activity of immobilized beta-galactosidase (beta-Gal) was monitored by following the hydrolysis of fluorescein mono-beta-D-galactopyranoside to fluorescein with laser-induced fluorescence.	Fluorescein	106-117	galactosidase beta 1	Homo sapiens	51-59
11478504-9	2001	Fecal beta-galactosidase significantly increased after lactulose.	Lactulose	55-64	galactosidase beta 1	Homo sapiens	6-24
11447073-7	2001	Analysis of beta-galactosidase staining revealed transmural myocardial gene expression among animals receiving adeno-beta-gal.	adeno-beta-gal	111-125	galactosidase beta 1	Homo sapiens	12-30
11464512-2	2001	To achieve this, we generated stable cell lines that express the modified tetracycline repressor molecule (rtTA) and the beta-gal gene under control of tetracycline-responsive cis-elements.	Tetracycline	152-164	galactosidase beta 1	Homo sapiens	121-129
11464512-3	2001	The resulting cell lines express functional beta-gal following treatment with the tetracycline analog doxycyclin (Dox).	Tetracycline	82-94	galactosidase beta 1	Homo sapiens	44-52
11464512-3	2001	The resulting cell lines express functional beta-gal following treatment with the tetracycline analog doxycyclin (Dox).	Doxycycline	102-112	galactosidase beta 1	Homo sapiens	44-52
11464512-3	2001	The resulting cell lines express functional beta-gal following treatment with the tetracycline analog doxycyclin (Dox).	Doxycycline	114-117	galactosidase beta 1	Homo sapiens	44-52
11464512-5	2001	The xenografts were found to express beta-gal when the animals were fed drinking water containing Dox.	Water	81-86	galactosidase beta 1	Homo sapiens	37-45
11464512-5	2001	The xenografts were found to express beta-gal when the animals were fed drinking water containing Dox.	Doxycycline	98-101	galactosidase beta 1	Homo sapiens	37-45
11397458-1	2001	The behaviour of five different hydrophobic beta-galactosidase derivatives, obtained by grafting different amount of butylmethacrylate (BMA) on planar nylon membranes, has been studied under isothermal and non-isothermal conditions.Under isothermal conditions the effect of the grafting percentage on the enzyme activity has been studied as a function of pH, temperature and substrate concentration.	butyl methacrylate	117-134	galactosidase beta 1	Homo sapiens	44-62
11467805-0	2001	Microencapsulation of beta-galactosidase with fatty acid esters.	Fatty Acids	46-63	galactosidase beta 1	Homo sapiens	22-40
11397458-1	2001	The behaviour of five different hydrophobic beta-galactosidase derivatives, obtained by grafting different amount of butylmethacrylate (BMA) on planar nylon membranes, has been studied under isothermal and non-isothermal conditions.Under isothermal conditions the effect of the grafting percentage on the enzyme activity has been studied as a function of pH, temperature and substrate concentration.	butyl methacrylate	136-139	galactosidase beta 1	Homo sapiens	44-62
11397458-1	2001	The behaviour of five different hydrophobic beta-galactosidase derivatives, obtained by grafting different amount of butylmethacrylate (BMA) on planar nylon membranes, has been studied under isothermal and non-isothermal conditions.Under isothermal conditions the effect of the grafting percentage on the enzyme activity has been studied as a function of pH, temperature and substrate concentration.	Nylons	151-156	galactosidase beta 1	Homo sapiens	44-62
11417694-1	2001	Viable lactic acid-producing bacteria in frozen dairy desserts can be a source of beta-galactosidase for persons who absorb lactose insufficiently.	Lactic Acid	7-18	galactosidase beta 1	Homo sapiens	82-100
11375903-8	2001	Both N-hydroxy-2AAF and N-hydroxy-PhIP stimulated a dose-dependent increase in bacterial beta-galactosidase activity.	n-hydroxy-2aaf	5-19	galactosidase beta 1	Homo sapiens	89-107
11375903-8	2001	Both N-hydroxy-2AAF and N-hydroxy-PhIP stimulated a dose-dependent increase in bacterial beta-galactosidase activity.	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	24-38	galactosidase beta 1	Homo sapiens	89-107
11166807-0	2001	trans-Sialidase catalyzed sialylation of beta-galactosyldisaccharide with an introduction of beta-galactosidase.	beta-galactosyldisaccharide	41-68	galactosidase beta 1	Homo sapiens	93-111
11180065-1	2001	The study of the effects of nonuniform distributions of immobilized beta-galactosidase on the overall reaction rate of the hydrolysis of lactose are presented.	Lactose	137-144	galactosidase beta 1	Homo sapiens	68-86
11272022-6	2001	However, the transgalactosylation of lactose from hexanol, catalyzed by a fungal beta-galactosidase, showed only a feeble reactivity.	Lactose	37-44	galactosidase beta 1	Homo sapiens	81-99
11272022-6	2001	However, the transgalactosylation of lactose from hexanol, catalyzed by a fungal beta-galactosidase, showed only a feeble reactivity.	Hexanols	50-57	galactosidase beta 1	Homo sapiens	81-99
11313816-1	2001	We demonstrate that relatively short single-stranded oligodeoxynucleotides, 25-61 bases homologous to the target sequence except for a single mismatch to the targeted base, are capable of correcting a single point mutation (G to A) in the mutant beta-galactosidase gene, in nuclear extracts, episome, and chromosome of mammalian cells, with correction rates of approximately 0.05%, 1% and 0.1%, respectively.	Oligodeoxyribonucleotides	53-74	galactosidase beta 1	Homo sapiens	246-264
11238974-9	2001	Mutations in EII(Man) or CcpA resulted in a relief of catabolite repression exerted by EII(Man) substrates on the activity of beta-galactosidase and beta-glucosidase, indicating that EII(Man) and CcpA are important components in catabolite repression in L. pentosus.	2-chloro-N(6)cyclopentyladenosine	25-29	galactosidase beta 1	Homo sapiens	126-144
11238974-9	2001	Mutations in EII(Man) or CcpA resulted in a relief of catabolite repression exerted by EII(Man) substrates on the activity of beta-galactosidase and beta-glucosidase, indicating that EII(Man) and CcpA are important components in catabolite repression in L. pentosus.	catabolite	54-64	galactosidase beta 1	Homo sapiens	126-144
11238974-9	2001	Mutations in EII(Man) or CcpA resulted in a relief of catabolite repression exerted by EII(Man) substrates on the activity of beta-galactosidase and beta-glucosidase, indicating that EII(Man) and CcpA are important components in catabolite repression in L. pentosus.	catabolite	229-239	galactosidase beta 1	Homo sapiens	126-144
11166807-1	2001	Introduction of beta-galactosidase into a trans-sialidase reaction, i.e. sialic acid transfer reaction from a donor substrate (alpha2,3-sialyllactose) to an acceptor substrate (beta-galactosyldisaccharide), could improve the yield of desired sialylated trisaccharide by hydrolyzing lactose, a byproduct from the donor.	N-Acetylneuraminic Acid	73-84	galactosidase beta 1	Homo sapiens	16-34
11161618-5	2001	Gold particles coated with plasmids containing the gene for the reporter beta-galactosidase were propelled by helium at 150--200 psi toward the exposed floor of the 4th ventricle.	Helium	110-116	galactosidase beta 1	Homo sapiens	73-91
11166807-1	2001	Introduction of beta-galactosidase into a trans-sialidase reaction, i.e. sialic acid transfer reaction from a donor substrate (alpha2,3-sialyllactose) to an acceptor substrate (beta-galactosyldisaccharide), could improve the yield of desired sialylated trisaccharide by hydrolyzing lactose, a byproduct from the donor.	N-acetylneuraminoyllactose	127-149	galactosidase beta 1	Homo sapiens	16-34
11166807-1	2001	Introduction of beta-galactosidase into a trans-sialidase reaction, i.e. sialic acid transfer reaction from a donor substrate (alpha2,3-sialyllactose) to an acceptor substrate (beta-galactosyldisaccharide), could improve the yield of desired sialylated trisaccharide by hydrolyzing lactose, a byproduct from the donor.	beta-galactosyldisaccharide	177-204	galactosidase beta 1	Homo sapiens	16-34
11166807-1	2001	Introduction of beta-galactosidase into a trans-sialidase reaction, i.e. sialic acid transfer reaction from a donor substrate (alpha2,3-sialyllactose) to an acceptor substrate (beta-galactosyldisaccharide), could improve the yield of desired sialylated trisaccharide by hydrolyzing lactose, a byproduct from the donor.	Trisaccharides	253-266	galactosidase beta 1	Homo sapiens	16-34
11166807-1	2001	Introduction of beta-galactosidase into a trans-sialidase reaction, i.e. sialic acid transfer reaction from a donor substrate (alpha2,3-sialyllactose) to an acceptor substrate (beta-galactosyldisaccharide), could improve the yield of desired sialylated trisaccharide by hydrolyzing lactose, a byproduct from the donor.	Lactose	142-149	galactosidase beta 1	Homo sapiens	16-34
11166807-2	2001	When trans-sialidase reaction was performed with stoichiometric amounts (2 mM) of alpha2,3-sialyllactose and Galbeta(1,3)GlcNAc, the yield of NeuAcalpha(2,3)Galbeta(1,3)GlcNAc increased from 45% to 75% by the coupling of Escherichia coli beta-galactosidase.	N-acetylneuraminoyllactose	82-104	galactosidase beta 1	Homo sapiens	238-256
11166807-2	2001	When trans-sialidase reaction was performed with stoichiometric amounts (2 mM) of alpha2,3-sialyllactose and Galbeta(1,3)GlcNAc, the yield of NeuAcalpha(2,3)Galbeta(1,3)GlcNAc increased from 45% to 75% by the coupling of Escherichia coli beta-galactosidase.	neuacalpha(2,3)galbeta(1,3)glcnac	142-175	galactosidase beta 1	Homo sapiens	238-256
11166807-7	2001	The conversion yield of the sialylation of Galbeta(1,6)GlcNAc could be improved by employing Bacillus circulans beta-galactosidase.	galbeta(1,6)glcnac	43-61	galactosidase beta 1	Homo sapiens	112-130
11196151-5	2001	Under these conditions, both Bcr-Abl-positive and -negative hematopoietic cells can be efficiently infected by adenovirus, as demonstrated by 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside staining of cells infected by beta-galactosidase (beta-GAL) adenovirus.	5-bromo-4-chloro-3-indolyl beta-galactoside	142-193	galactosidase beta 1	Homo sapiens	224-242
11196151-5	2001	Under these conditions, both Bcr-Abl-positive and -negative hematopoietic cells can be efficiently infected by adenovirus, as demonstrated by 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside staining of cells infected by beta-galactosidase (beta-GAL) adenovirus.	5-bromo-4-chloro-3-indolyl beta-galactoside	142-193	galactosidase beta 1	Homo sapiens	244-252
11097942-0	2000	Evaluation of p-naphtholbenzein-beta-D-galactoside as a substrate for bacterial beta-galactosidase.	p-naphtholbenzeingalactoside	14-50	galactosidase beta 1	Homo sapiens	80-98
11550799-1	2001	Lysosomal enzymes sialidase (alpha-neuraminidase), beta-galactosidase, and N-acetylaminogalacto-6-sulfate sulfatase are involved in the catabolism of glycolipids, glycoproteins, and oligosaccharides.	Glycolipids	150-161	galactosidase beta 1	Homo sapiens	51-69
11550799-1	2001	Lysosomal enzymes sialidase (alpha-neuraminidase), beta-galactosidase, and N-acetylaminogalacto-6-sulfate sulfatase are involved in the catabolism of glycolipids, glycoproteins, and oligosaccharides.	Oligosaccharides	182-198	galactosidase beta 1	Homo sapiens	51-69
10942779-9	2000	The enzymatic hydrolysis of the ganglioside GM1 is catalyzed by beta-galactosidase, a water-soluble acid exohydrolase.	Gangliosides	32-43	galactosidase beta 1	Homo sapiens	64-82
11228536-4	2000	Furthermore, intravesical administration of the LacZ adenovirus vector resulted in significant beta-galactosidase expression in these bladder tumors as well as the normal urothelium, which was associated with the removal of the glycosoaminoglycan layer.	glycosoaminoglycan	228-246	galactosidase beta 1	Homo sapiens	95-113
10942779-9	2000	The enzymatic hydrolysis of the ganglioside GM1 is catalyzed by beta-galactosidase, a water-soluble acid exohydrolase.	G(M1) Ganglioside	44-47	galactosidase beta 1	Homo sapiens	64-82
10942779-9	2000	The enzymatic hydrolysis of the ganglioside GM1 is catalyzed by beta-galactosidase, a water-soluble acid exohydrolase.	Water	86-91	galactosidase beta 1	Homo sapiens	64-82
10942779-11	2000	In this study we demonstrate that an activator protein is required for the enzymatic degradation of membrane-bound ganglioside GM1 and that both SAP-B and the GM2 activator protein significantly enhance the degradation of the ganglioside GM1 by acid beta-galactosidase in a liposomal, detergent-free assay system.	Gangliosides	115-126	galactosidase beta 1	Homo sapiens	250-268
10942779-11	2000	In this study we demonstrate that an activator protein is required for the enzymatic degradation of membrane-bound ganglioside GM1 and that both SAP-B and the GM2 activator protein significantly enhance the degradation of the ganglioside GM1 by acid beta-galactosidase in a liposomal, detergent-free assay system.	G(M1) Ganglioside	127-130	galactosidase beta 1	Homo sapiens	250-268
10942779-11	2000	In this study we demonstrate that an activator protein is required for the enzymatic degradation of membrane-bound ganglioside GM1 and that both SAP-B and the GM2 activator protein significantly enhance the degradation of the ganglioside GM1 by acid beta-galactosidase in a liposomal, detergent-free assay system.	Gangliosides	226-237	galactosidase beta 1	Homo sapiens	250-268
10942779-11	2000	In this study we demonstrate that an activator protein is required for the enzymatic degradation of membrane-bound ganglioside GM1 and that both SAP-B and the GM2 activator protein significantly enhance the degradation of the ganglioside GM1 by acid beta-galactosidase in a liposomal, detergent-free assay system.	G(M1) Ganglioside	238-241	galactosidase beta 1	Homo sapiens	250-268
10942779-14	2000	Assays utilizing surface plasmon resonance spectroscopy showed that bis(monoacylglycero)phosphate increases the binding of both beta-galactosidase and activator proteins to substrate-carrying membranes.	bis(monoacylglyceryl)phosphate	68-97	galactosidase beta 1	Homo sapiens	128-146
11146413-3	2000	The light absorption of hemoglobin is similar to the absorption of several colorimetric products of the commonly used beta-galactosidase substrates, including o-nitrophenyl-beta-D-galactopyranoside (ONPG) and chlorophenol red galactopyranoside (CPRG).	2-nitrophenylgalactoside	159-197	galactosidase beta 1	Homo sapiens	118-136
11197525-3	2000	Here we propose that repeated stimulation of WI-38 fibroblasts with TNF-alpha or IL-1alpha can generate enough ROS to accelerate the transition in the fibroblast morphotypes and increase the proportion of cells positive for senescence associated beta-galactosidase activity.	Reactive Oxygen Species	111-114	galactosidase beta 1	Homo sapiens	246-264
11050185-9	2000	Changing a serine residue (Ser(2054)) to aspartic acid mutated the potential protein kinase A site adjacent to NLS2(APC), resulting in both inhibition of the NLS2(APC)-mediated nuclear import of a chimeric beta-galactosidase fusion protein and a reduction of full-length APC nuclear localization.	Serine	11-17	galactosidase beta 1	Homo sapiens	206-224
11146413-9	2000	CPRG substrate, in combination with the reducer agent mercaptoethanol, was found to be the optimal reagent for quantifying beta-galactosidase activity in the presence of blood after nonviral in vivo reporter gene transfection, even with a relatively low transfer efficiency.	chlorophenol red galactopyranoside	0-4	galactosidase beta 1	Homo sapiens	123-141
11017877-4	2000	Lysosomal alkalinisation with chloroquine or bafilomycin A(1), as well as equilibration of the intracellular milieu to pH 6 with nigericin, caused a profound (92-99%) inhibition of the total intracellular (beta)-galactosidase activity.	bafilomycin A	45-58	galactosidase beta 1	Homo sapiens	206-225
11017877-4	2000	Lysosomal alkalinisation with chloroquine or bafilomycin A(1), as well as equilibration of the intracellular milieu to pH 6 with nigericin, caused a profound (92-99%) inhibition of the total intracellular (beta)-galactosidase activity.	Nigericin	129-138	galactosidase beta 1	Homo sapiens	206-225
11017877-7	2000	Acridine Orange staining revealed an increase in lysosomal content with replicative age, which correlated with the increase in (beta)-galactosidase.	Acridine Orange	0-15	galactosidase beta 1	Homo sapiens	128-147
10938379-4	2000	We show that H2O2 leads to endogenous beta-galactosidase expression similar to senescence, but instead of G1 arrest, it leads to G2/M growth arrest without induction of either p16 or p14arf.	Hydrogen Peroxide	13-17	galactosidase beta 1	Homo sapiens	38-56
10994980-6	2000	The enzyme label beta-GAL converted the substrate 4-aminophenyl-beta-D-galactopyranoside (4-APG) into 4-aminophenol (4-AP), which subsequently was detected by a cellobiose dehydrogenase (CDH) modified solid graphite electrode.	4-aminophenyl-beta-galactoside	50-88	galactosidase beta 1	Homo sapiens	17-25
10994980-6	2000	The enzyme label beta-GAL converted the substrate 4-aminophenyl-beta-D-galactopyranoside (4-APG) into 4-aminophenol (4-AP), which subsequently was detected by a cellobiose dehydrogenase (CDH) modified solid graphite electrode.	4-apg	90-95	galactosidase beta 1	Homo sapiens	17-25
10994980-6	2000	The enzyme label beta-GAL converted the substrate 4-aminophenyl-beta-D-galactopyranoside (4-APG) into 4-aminophenol (4-AP), which subsequently was detected by a cellobiose dehydrogenase (CDH) modified solid graphite electrode.	4-aminophenol	102-115	galactosidase beta 1	Homo sapiens	17-25
10994980-6	2000	The enzyme label beta-GAL converted the substrate 4-aminophenyl-beta-D-galactopyranoside (4-APG) into 4-aminophenol (4-AP), which subsequently was detected by a cellobiose dehydrogenase (CDH) modified solid graphite electrode.	4-aminophenol	90-94	galactosidase beta 1	Homo sapiens	17-25
10994980-6	2000	The enzyme label beta-GAL converted the substrate 4-aminophenyl-beta-D-galactopyranoside (4-APG) into 4-aminophenol (4-AP), which subsequently was detected by a cellobiose dehydrogenase (CDH) modified solid graphite electrode.	Graphite	207-215	galactosidase beta 1	Homo sapiens	17-25
11026538-1	2000	Described here are the synthesis of five-membered iminocyclitols with galacto-configuration and a pseudodisaccharide, and their inhibitory activities against beta-galactosyltransferase, beta-galactosidase and alpha-mannosidase.	iminocyclitols	50-64	galactosidase beta 1	Homo sapiens	186-204
10987139-4	2000	Hydrogen peroxide-treated cells showed an enhancement of senescence-associated beta-galactosidase activity.	Hydrogen Peroxide	0-17	galactosidase beta 1	Homo sapiens	79-97
10964679-5	2000	When Jurkat cells were treated with endo-beta-galactosidase to cleave sialylated poly-N-acetyllactosaminyl saccharide chains from the cell surface before induction of apoptosis, the binding of anti-band 3 IgG was abolished.	poly-n-acetyllactosaminyl saccharide	81-117	galactosidase beta 1	Homo sapiens	41-59
10862685-1	2000	A new easily scalable approach to the recovery of biologically active oligosaccharides from milk has been developed which relies on the combination of enzymatic treatment of defatted milk using beta-galactosidase and nanofiltration.	Oligosaccharides	70-86	galactosidase beta 1	Homo sapiens	194-212
10933715-4	2000	Interaction with this gene turned out to be very strong, producing beta-galactosidase levels 100-fold greater than the background as measured in an ONPG (o-nitrophenyl-beta-D-galactopyranoside) assay.	2-nitrophenylgalactoside	154-192	galactosidase beta 1	Homo sapiens	67-85
10854064-7	2000	The level of cytochemically detectable SA beta-gal was elevated in confluent nontransformed fibroblast cultures, in immortal fibroblast cultures that had reached a high cell density, and in low-density, young, normal cultures oxidatively challenged by treatment with H2O2.	Hydrogen Peroxide	267-271	galactosidase beta 1	Homo sapiens	42-50
10891416-11	2000	This sequence proved not only necessary but also sufficient for nuclear localization, because its substitution with a six-alanine stretch prevented nuclear translocation of the beta-galactosidase-Pol peptide fusion.	Alanine	122-129	galactosidase beta 1	Homo sapiens	177-195
10961388-5	2000	The hydroxyurea-treated cells showed positive senescence associated-beta-galactosidase staining, a senescence index, and the accumulation of cdk (cyclin dependent kinase) inhibitors, such as p16INK4a, p21Waf1, and p27Kip1, implicated in cellular senescence.	Hydroxyurea	4-15	galactosidase beta 1	Homo sapiens	68-86
10871337-8	2000	We also demonstrate that the presence of vinblastine in a coculture of cells that expressed beta-galactosidase together with cells that expressed CYP3A4 strongly selected for the latter cells, resulting in an increased level of CYP3A4 in the surviving cell population.	Vinblastine	41-52	galactosidase beta 1	Homo sapiens	92-110
10839995-0	2000	Characterization of beta-galactosidase mutations Asp332--&gt;Asn and Arg148--&gt;Ser, and a polymorphism, Ser532--&gt;Gly, in a case of GM1 gangliosidosis.	Asparagine	61-64	galactosidase beta 1	Homo sapiens	20-38
10839995-0	2000	Characterization of beta-galactosidase mutations Asp332--&gt;Asn and Arg148--&gt;Ser, and a polymorphism, Ser532--&gt;Gly, in a case of GM1 gangliosidosis.	Serine	81-84	galactosidase beta 1	Homo sapiens	20-38
11032241-1	2000	alpha-Mannosidase and beta-galactosidase were released from boar sperm into the medium by treatment with calcium ionophore A23187 or by 0.2% Brij-35/2% acetic acid.	Calcium	105-112	galactosidase beta 1	Homo sapiens	22-40
11032241-1	2000	alpha-Mannosidase and beta-galactosidase were released from boar sperm into the medium by treatment with calcium ionophore A23187 or by 0.2% Brij-35/2% acetic acid.	Calcimycin	123-129	galactosidase beta 1	Homo sapiens	22-40
11032241-1	2000	alpha-Mannosidase and beta-galactosidase were released from boar sperm into the medium by treatment with calcium ionophore A23187 or by 0.2% Brij-35/2% acetic acid.	Acetic Acid	152-163	galactosidase beta 1	Homo sapiens	22-40
10953459-2	2000	beta-Galactosidase secreted by the callus culture, or the roots of sprouting plants, hydrolyzes the substrate (6-bromo-2-naphthyl-beta-D-galactopyranoside) to produce beta-D-galactose and 6-bromo-2-naphthol, which after simultaneous azocoupling with hexazotized p-rosaniline, or basic fuchsine, produce a reddish brown compound, nearly insoluble in water (a diazonium salt).	6-bromo-2-naphthyl-beta-galactopyranoside	111-154	galactosidase beta 1	Homo sapiens	0-18
10950176-5	2000	More than 95% of beta-galactosidase positive cells were also BrdU positive suggesting that the majority of beta-galactosidase positive cells were in the S-phase of the cell cycle at the time of CXL retroviral administration.	Cyclohexanols	194-197	galactosidase beta 1	Homo sapiens	17-35
10950176-5	2000	More than 95% of beta-galactosidase positive cells were also BrdU positive suggesting that the majority of beta-galactosidase positive cells were in the S-phase of the cell cycle at the time of CXL retroviral administration.	Cyclohexanols	194-197	galactosidase beta 1	Homo sapiens	107-125
10953459-2	2000	beta-Galactosidase secreted by the callus culture, or the roots of sprouting plants, hydrolyzes the substrate (6-bromo-2-naphthyl-beta-D-galactopyranoside) to produce beta-D-galactose and 6-bromo-2-naphthol, which after simultaneous azocoupling with hexazotized p-rosaniline, or basic fuchsine, produce a reddish brown compound, nearly insoluble in water (a diazonium salt).	beta-D-galactose	167-183	galactosidase beta 1	Homo sapiens	0-18
10953459-2	2000	beta-Galactosidase secreted by the callus culture, or the roots of sprouting plants, hydrolyzes the substrate (6-bromo-2-naphthyl-beta-D-galactopyranoside) to produce beta-D-galactose and 6-bromo-2-naphthol, which after simultaneous azocoupling with hexazotized p-rosaniline, or basic fuchsine, produce a reddish brown compound, nearly insoluble in water (a diazonium salt).	6-bromo-2-naphthol	188-206	galactosidase beta 1	Homo sapiens	0-18
10953459-2	2000	beta-Galactosidase secreted by the callus culture, or the roots of sprouting plants, hydrolyzes the substrate (6-bromo-2-naphthyl-beta-D-galactopyranoside) to produce beta-D-galactose and 6-bromo-2-naphthol, which after simultaneous azocoupling with hexazotized p-rosaniline, or basic fuchsine, produce a reddish brown compound, nearly insoluble in water (a diazonium salt).	pararosaniline	262-274	galactosidase beta 1	Homo sapiens	0-18
10953459-2	2000	beta-Galactosidase secreted by the callus culture, or the roots of sprouting plants, hydrolyzes the substrate (6-bromo-2-naphthyl-beta-D-galactopyranoside) to produce beta-D-galactose and 6-bromo-2-naphthol, which after simultaneous azocoupling with hexazotized p-rosaniline, or basic fuchsine, produce a reddish brown compound, nearly insoluble in water (a diazonium salt).	Rosaniline Dyes	279-293	galactosidase beta 1	Homo sapiens	0-18
10953459-2	2000	beta-Galactosidase secreted by the callus culture, or the roots of sprouting plants, hydrolyzes the substrate (6-bromo-2-naphthyl-beta-D-galactopyranoside) to produce beta-D-galactose and 6-bromo-2-naphthol, which after simultaneous azocoupling with hexazotized p-rosaniline, or basic fuchsine, produce a reddish brown compound, nearly insoluble in water (a diazonium salt).	Water	349-354	galactosidase beta 1	Homo sapiens	0-18
10953459-2	2000	beta-Galactosidase secreted by the callus culture, or the roots of sprouting plants, hydrolyzes the substrate (6-bromo-2-naphthyl-beta-D-galactopyranoside) to produce beta-D-galactose and 6-bromo-2-naphthol, which after simultaneous azocoupling with hexazotized p-rosaniline, or basic fuchsine, produce a reddish brown compound, nearly insoluble in water (a diazonium salt).	diazonium salt	358-372	galactosidase beta 1	Homo sapiens	0-18
10757351-1	2000	Mutations in the lysosomal acid beta-galactosidase (EC 3.2.1.23) underlie two different disorders: GM1 gangliosidosis, which involves the nervous system and visceral organs to varying extents, and Morquio"s syndrome type B (Morquio B disease), which is a skeletal-connective tissue disease without any CNS symptoms.	G(M1) Ganglioside	99-102	galactosidase beta 1	Homo sapiens	32-50
10802135-3	2000	When a drop of bacteriolytic compound is placed on the agar, beta-galactosidase is released from the bacteria to the external solid medium where it hydrolyzes X-Gal substrate analogue, developing a blue halo at the edge of the inhibition growth zone.	Agar	55-59	galactosidase beta 1	Homo sapiens	61-79
10830782-6	2000	When mice bearing MDA-MB-231 BAG tumor xenografts were treated intravenously with a single injection of doxorubicin (5 mg/kg), the mean tumor volume after 16 days was reduced 4-fold in the group of doxorubicin-treated mice compared with saline-treated control mice, and the mean level of plasma E. coli beta-galactosidase was correspondingly reduced 3.8-fold in the doxorubicin-treated mice compared with control mice.	Doxorubicin	104-115	galactosidase beta 1	Homo sapiens	303-321
10830782-6	2000	When mice bearing MDA-MB-231 BAG tumor xenografts were treated intravenously with a single injection of doxorubicin (5 mg/kg), the mean tumor volume after 16 days was reduced 4-fold in the group of doxorubicin-treated mice compared with saline-treated control mice, and the mean level of plasma E. coli beta-galactosidase was correspondingly reduced 3.8-fold in the doxorubicin-treated mice compared with control mice.	Doxorubicin	198-209	galactosidase beta 1	Homo sapiens	303-321
10830782-6	2000	When mice bearing MDA-MB-231 BAG tumor xenografts were treated intravenously with a single injection of doxorubicin (5 mg/kg), the mean tumor volume after 16 days was reduced 4-fold in the group of doxorubicin-treated mice compared with saline-treated control mice, and the mean level of plasma E. coli beta-galactosidase was correspondingly reduced 3.8-fold in the doxorubicin-treated mice compared with control mice.	Doxorubicin	198-209	galactosidase beta 1	Homo sapiens	303-321
10751364-4	2000	The number of PMN migrating in response to N-formyl-Met-Leu-Phe across inverted CF(15) monolayers expressing beta-galactosidase was similar to that seen across CF(15) monolayers rescued with CFTR, whatever the proportion of cells expressing the transgene.	N-Formylmethionine Leucyl-Phenylalanine	43-63	galactosidase beta 1	Homo sapiens	109-127
10792658-0	2000	Alizarin-beta-D-galactoside: a new substrate for the detection of bacterial beta-galactosidase.	alizarin-beta-d-galactoside	0-27	galactosidase beta 1	Homo sapiens	76-94
10792658-6	2000	We conclude that alizarin-beta-D-galactoside is a highly sensitive substrate for the demonstration of beta-galactosidase.	alizarin-beta-d-galactoside	17-44	galactosidase beta 1	Homo sapiens	102-120
10821566-5	2000	Colonies that exhibited a blue color were selected for quantitative beta-gal activities using the o-nitrophenyl-beta-galactoside (ONPG) assay.	2-nitrophenylgalactoside	98-128	galactosidase beta 1	Homo sapiens	68-76
10821566-9	2000	The highest beta-gal increases, when induced during growth in lactose, for mutants of each culture were 137% for L. delbrueckii ssp.	Lactose	62-69	galactosidase beta 1	Homo sapiens	12-20
10757351-2	2000	This article shows that transduction of human GM1 gangliosidosis fibroblasts with retrovirus vectors encoding the human acid beta-galactosidase cDNA leads to complete correction of the enzymatic deficiency.	G(M1) Ganglioside	46-49	galactosidase beta 1	Homo sapiens	125-143
10803543-8	2000	Copper produced a concentration/response inhibition of beta-galactosidase and dehydrogenase with EC50 values of 78.39 and 24.77 mg Cu/kg soil, respectively.	Copper	0-6	galactosidase beta 1	Homo sapiens	55-73
10585716-5	1999	X-gal staining demonstrated widespread beta-gal expression in multiple fetal tissues and cell types.	5-bromo-4-chloro-3-indolyl beta-galactoside	0-5	galactosidase beta 1	Homo sapiens	39-47
10751590-0	2000	Characterization of beta-galactosidase in leukocytes and fibroblasts of GM1 gangliosidosis heterozygotes compared to normal subjects.	G(M1) Ganglioside	72-75	galactosidase beta 1	Homo sapiens	20-38
10751590-1	2000	OBJECTIVES: Characterization of beta-galactosidase in leukocytes and fibroblasts of heterozygotes for GM1 type I.	G(M1) Ganglioside	102-105	galactosidase beta 1	Homo sapiens	32-50
10751590-2	2000	DESIGN AND METHODS: Leukocyte and fibroblast beta-galactosidase activity was determined fluorimetrically using 4-methylumbelliferyl-beta-D-galactoside as an artificial substrate.	4-methylumbelliferyl-galactopyranoside	111-150	galactosidase beta 1	Homo sapiens	45-63
10603381-11	2000	The human epitopes appeared to be located on O-polysaccharide chains containing endo-beta-galactosidase-sensitive galactose residues as the backbone.	Galactose	114-123	galactosidase beta 1	Homo sapiens	85-103
10758912-5	2000	Plasmids encoding nuclear localizing beta galactosidase or luciferase (pRSVLuc, pCLuc4, pSV2Luc) were complexed in water at various +/- charge ratios using cationic lipids (Lipofectin, DOTAP, DOGS), polyethylene imines (25 and 750 kDa), and with degraded 6th generation starburst polyamidoamine dendrimers.	Water	115-120	galactosidase beta 1	Homo sapiens	37-55
10594371-0	1999	Combined effects of trehalose and cations on the thermal resistance of beta-galactosidase in freeze-dried systems.	Trehalose	20-29	galactosidase beta 1	Homo sapiens	71-89
10594371-1	1999	The purpose of this study was to investigate the combined effects of trehalose and cations on the preservation of beta-galactosidase in freeze-dried systems and their relationship to physical properties.	Trehalose	69-78	galactosidase beta 1	Homo sapiens	114-132
10611604-0	1999	beta-galactosidase assay using capillary electrophoresis laser-induced fluorescence detection and resorufin-beta-D-galactopyranoside as substrate.	resorufin galactopyranoside	98-132	galactosidase beta 1	Homo sapiens	0-18
10611604-1	1999	beta-Galactosidase was incubated for 60 min with the fluorogenic substrate resorufin-beta-D-galactopyranoside, which is converted by the action of the enzyme into resorufin and galactose.	resorufin galactopyranoside	75-109	galactosidase beta 1	Homo sapiens	0-18
10611604-1	1999	beta-Galactosidase was incubated for 60 min with the fluorogenic substrate resorufin-beta-D-galactopyranoside, which is converted by the action of the enzyme into resorufin and galactose.	Galactose	177-186	galactosidase beta 1	Homo sapiens	0-18
10568814-3	1999	After exposure to cisplatin, all the cell lines underwent growth arrest and expressed the senescence marker senescence-associated beta-galactosidase, but showed none of the features of apoptosis.	Cisplatin	18-27	galactosidase beta 1	Homo sapiens	130-148
10559283-11	1999	C(6)-ceramide, fumonisin B(1) (FB(1)), or etoposide was used to initiate PCD following transfection of cells with plasmids expressing LR gene products and the beta-galactosidase gene.	N-caproylsphingosine	0-13	galactosidase beta 1	Homo sapiens	159-177
10713206-0	2000	Influence of water activity and aqueous solvent ordering on enzyme kinetics of alcohol dehydrogenase, lysozyme, and beta-galactosidase.	Water	13-18	galactosidase beta 1	Homo sapiens	116-134
10713206-1	2000	Effects of the water activity (a(w)) and the solvent ordering, as determined by the activity coefficient of water, were investigated on the enzyme kinetics of alcohol dehydrogenase, lysozyme, and beta-galactosidase in various aqueous solutions.	Water	15-20	galactosidase beta 1	Homo sapiens	196-214
10713206-1	2000	Effects of the water activity (a(w)) and the solvent ordering, as determined by the activity coefficient of water, were investigated on the enzyme kinetics of alcohol dehydrogenase, lysozyme, and beta-galactosidase in various aqueous solutions.	Water	108-113	galactosidase beta 1	Homo sapiens	196-214
10714936-0	2000	Ceramide induces expression of the senescence histochemical marker, beta-galactosidase, in human fibroblasts.	Ceramides	0-8	galactosidase beta 1	Homo sapiens	68-86
10714936-3	2000	We investigated the ability of ceramide to induce the expression of beta-Gal and correlated this with cell proliferation.	Ceramides	31-39	galactosidase beta 1	Homo sapiens	68-76
10714936-4	2000	We find that D-e-C6-ceramide, induces the expression of acidic beta-Gal in fetal lung-derived Wi-38 human diploid fibroblasts.	d-e-c6-ceramide	13-28	galactosidase beta 1	Homo sapiens	63-71
10714936-8	2000	The induction of beta-Gal expression is specific to C6-ceramide.	N-caproylsphingosine	52-63	galactosidase beta 1	Homo sapiens	17-25
10667153-4	2000	Moreover, acid beta-galactosidase activity was demonstrated in serial cytosediments by the indigogenic method of Lojda.	cytosediments	70-83	galactosidase beta 1	Homo sapiens	15-33
10667153-4	2000	Moreover, acid beta-galactosidase activity was demonstrated in serial cytosediments by the indigogenic method of Lojda.	lojda	113-118	galactosidase beta 1	Homo sapiens	15-33
10737154-6	2000	The transfection efficiency, estimated by the expression of control, beta-galactosidase gene, was about 50% in COS-7 but rarely exceeded 5% in VSMC.	carbonyl sulfide	111-114	galactosidase beta 1	Homo sapiens	69-87
11133016-5	1999	The branch selectivity of the addition of N-acetylglucosamine to compounds 1 and 2 was then characterized by endo-beta-galactosidase digestion of the heptasaccharides, followed by isolation of the resultant pentasaccharides on C18 reverse-phase silica cartridges.	Acetylglucosamine	42-61	galactosidase beta 1	Homo sapiens	114-132
11133016-6	1999	Comparison of the amount of radiolabel to a control reaction lacking endo-beta-galactosidase indicated the favored site of GlcNAc addition to be the lower beta1,2-branch over the beta1,6 branch by a 3 :1 ratio.	Acetylglucosamine	123-129	galactosidase beta 1	Homo sapiens	74-92
10578056-1	1999	5-Bromodeoxyuridine was found to induce flat and enlarged cell shape, characteristics of senescent cells, and senescence-associated beta-galactosidase in mammalian cells regardless of cell type or species.	Bromodeoxyuridine	0-19	galactosidase beta 1	Homo sapiens	132-150
10571006-0	1999	Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein.	G(M1) Ganglioside	19-22	galactosidase beta 1	Homo sapiens	107-125
10572922-3	1999	A549, Calu3, and H292 cells grown to 90% confluence were transfected for 18 h with a plasmid DNA containing a beta-galactosidase reporter gene (pCMVlacZ) using lipofectin plus a lectin as the vector.	1,2-dielaidoylphosphatidylethanolamine	160-170	galactosidase beta 1	Homo sapiens	110-128
10522705-3	1999	In addition, non-reducing galactosyl residues were removed with beta-galactosidase to furnish GlcNAc terminated compounds.	2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose	94-100	galactosidase beta 1	Homo sapiens	64-82
10479352-0	1999	Hydroxypropyl-beta-cyclodextrin inhibits spray-drying-induced inactivation of beta-galactosidase.	2-Hydroxypropyl-beta-cyclodextrin	0-31	galactosidase beta 1	Homo sapiens	78-96
10479352-5	1999	Spray-drying beta-galactosidase in the presence of sucrose did not prevent inactivation.	Sucrose	51-58	galactosidase beta 1	Homo sapiens	13-31
10516283-7	1999	CO(2) stimulated NBC activity normally in beta-galactosidase-expressing and untransfected control cells.	co(2)	0-5	galactosidase beta 1	Homo sapiens	42-60
10505854-8	1999	Similar results were obtained using primary tumor cell cultures, where beta-gal expression was increased 1.5- to 10.7-fold (mean = 3.6) by polybrene, 1.8- to 7.5-fold (mean = 3.4) by DOTAP, and 2.3- to 10.4-fold (mean = 4.8) by protamine sulfate.	Hexadimethrine Bromide	139-148	galactosidase beta 1	Homo sapiens	71-79
10505854-8	1999	Similar results were obtained using primary tumor cell cultures, where beta-gal expression was increased 1.5- to 10.7-fold (mean = 3.6) by polybrene, 1.8- to 7.5-fold (mean = 3.4) by DOTAP, and 2.3- to 10.4-fold (mean = 4.8) by protamine sulfate.	1,2-dioleoyloxy-3-(trimethylammonium)propane	183-188	galactosidase beta 1	Homo sapiens	71-79
10479352-6	1999	However, after spray-drying beta-galactosidase in the presence of HP-beta-CD, or HP-beta-CD and sucrose, full catalytic activity was exhibited on reconstitution.	2-Hydroxypropyl-beta-cyclodextrin	66-76	galactosidase beta 1	Homo sapiens	28-46
10453946-13	1999	Following LZBC infection, 10% HepG2 cells were beta-galactosidase-positive by X-gal staining and Bcl-2-positive.	lzbc	10-14	galactosidase beta 1	Homo sapiens	47-65
10479352-6	1999	However, after spray-drying beta-galactosidase in the presence of HP-beta-CD, or HP-beta-CD and sucrose, full catalytic activity was exhibited on reconstitution.	2-Hydroxypropyl-beta-cyclodextrin	81-91	galactosidase beta 1	Homo sapiens	28-46
10479352-6	1999	However, after spray-drying beta-galactosidase in the presence of HP-beta-CD, or HP-beta-CD and sucrose, full catalytic activity was exhibited on reconstitution.	Sucrose	96-103	galactosidase beta 1	Homo sapiens	28-46
10496221-4	1999	Beta-galactosidase localization in transfectants was visualized by incubation with X-gal and also quantitated by an o-nitrophenyl beta-D-galactopyranoside (ONPG) assay.	5-bromo-4-chloro-3-indolyl beta-galactoside	83-88	galactosidase beta 1	Homo sapiens	0-18
10496221-4	1999	Beta-galactosidase localization in transfectants was visualized by incubation with X-gal and also quantitated by an o-nitrophenyl beta-D-galactopyranoside (ONPG) assay.	2-nitrophenylgalactoside	116-154	galactosidase beta 1	Homo sapiens	0-18
10452797-6	1999	A beta-galactosidase substrate was also prepared based on 6, 8-difluoro-4-methylumbelliferone.	6,8-difluoro-4-methylumbelliferyl sulfate	58-93	galactosidase beta 1	Homo sapiens	2-20
10452797-7	1999	This substrate, 6, 8-difluoro-4-methylumbelliferyl beta-d-galactopyranoside (DiFMUG), was found to be considerably more sensitive than the commonly used substrate 4-methylumbelliferyl beta-d-galactopyranoside (MUG), for the detection of beta-galactosidase activity at pH 7.	6, 8-difluoro-4-methylumbelliferyl beta-d-galactopyranoside	16-75	galactosidase beta 1	Homo sapiens	237-255
10452797-7	1999	This substrate, 6, 8-difluoro-4-methylumbelliferyl beta-d-galactopyranoside (DiFMUG), was found to be considerably more sensitive than the commonly used substrate 4-methylumbelliferyl beta-d-galactopyranoside (MUG), for the detection of beta-galactosidase activity at pH 7.	6,8-Difluoro-4-methyl-7-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one	77-83	galactosidase beta 1	Homo sapiens	237-255
10452797-7	1999	This substrate, 6, 8-difluoro-4-methylumbelliferyl beta-d-galactopyranoside (DiFMUG), was found to be considerably more sensitive than the commonly used substrate 4-methylumbelliferyl beta-d-galactopyranoside (MUG), for the detection of beta-galactosidase activity at pH 7.	4-methylumbelliferyl-galactopyranoside	30-75	galactosidase beta 1	Homo sapiens	237-255
10452797-8	1999	DiFMUP and DiFMUG should have great utility for the continuous assay of phosphatase and beta-galactosidase activity, respectively, at neutral and acid pH.	6,8-difluoro-4-methylumbelliferyl phosphate	0-6	galactosidase beta 1	Homo sapiens	88-106
10452797-8	1999	DiFMUP and DiFMUG should have great utility for the continuous assay of phosphatase and beta-galactosidase activity, respectively, at neutral and acid pH.	6,8-Difluoro-4-methyl-7-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one	11-17	galactosidase beta 1	Homo sapiens	88-106
10453946-14	1999	In cells surviving after anti-Fas treatment, the proportion of beta-galactosidase-positive cells increased to 50% and the beta-galactosidase activity increased 6-fold, indicating that Bcl-2 expression protected the cells from Fas-mediated apoptosis.	ammonium ferrous sulfate	30-33	galactosidase beta 1	Homo sapiens	63-81
10453946-14	1999	In cells surviving after anti-Fas treatment, the proportion of beta-galactosidase-positive cells increased to 50% and the beta-galactosidase activity increased 6-fold, indicating that Bcl-2 expression protected the cells from Fas-mediated apoptosis.	ammonium ferrous sulfate	30-33	galactosidase beta 1	Homo sapiens	122-140
10232598-5	1999	In vitro infection of up to seven different epithelial cancer cell lines with Ad.DF3.betaGAL or Ad.DF3.BAX resulted in expression of either beta-galactosidase activity or HA-BAX protein, respectively, which was highly correlated with DF3 levels.	N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide	81-84	galactosidase beta 1	Homo sapiens	140-158
10385681-8	1999	By cotransfecting COMT promoter-chloramphenicol acetyltransferase reporter genes with human estrogen receptor cDNA and pSV-beta-galactosidase plasmids into COS-7 cells, we showed that 17-beta-estradiol could down-regulate chloramphenicol acetyltransferase activities, and COMT promoter activities dose-dependently.	Estradiol	184-201	galactosidase beta 1	Homo sapiens	123-141
10364488-5	1999	The pair of lysine residues in this motif constitutes an essential element of the C-terminal NLS as mutation of this motif to AAQK directly affected the nuclear localization of either pp50 or beta-galactosidase fusion proteins containing the C-terminal portion of pp50.	Lysine	12-18	galactosidase beta 1	Homo sapiens	192-210
10414517-9	1999	Cyclosporin A administration led to the most persistent beta-galactosidase activity in neurons at 5 and 8 days.	Cyclosporine	0-13	galactosidase beta 1	Homo sapiens	56-74
10361169-0	1999	Development of dried liposomes containing beta-galactosidase for the digestion of lactose in milk.	Lactose	82-89	galactosidase beta 1	Homo sapiens	42-60
10361169-2	1999	In order to cope with this shortcoming, we examined whether beta-galactosidase, which hydrolyzes lactose, added to the whole milk in the form of dried liposomes, would be able to digest lactose in milk following the lysis of liposomes in the presence of bile salts.	Lactose	97-104	galactosidase beta 1	Homo sapiens	60-78
10361169-2	1999	In order to cope with this shortcoming, we examined whether beta-galactosidase, which hydrolyzes lactose, added to the whole milk in the form of dried liposomes, would be able to digest lactose in milk following the lysis of liposomes in the presence of bile salts.	Lactose	186-193	galactosidase beta 1	Homo sapiens	60-78
10361169-2	1999	In order to cope with this shortcoming, we examined whether beta-galactosidase, which hydrolyzes lactose, added to the whole milk in the form of dried liposomes, would be able to digest lactose in milk following the lysis of liposomes in the presence of bile salts.	Bile Acids and Salts	254-264	galactosidase beta 1	Homo sapiens	60-78
10361169-9	1999	Lactose hydrolysis in the presence of deoxycholic acid after the addition of dried liposome-entrapped beta-galactosidase to whole milk was proportional to the quantity of entrapped beta-galactosidase and the amount of dried liposomes added.	Lactose	0-7	galactosidase beta 1	Homo sapiens	102-120
10361169-9	1999	Lactose hydrolysis in the presence of deoxycholic acid after the addition of dried liposome-entrapped beta-galactosidase to whole milk was proportional to the quantity of entrapped beta-galactosidase and the amount of dried liposomes added.	Lactose	0-7	galactosidase beta 1	Homo sapiens	181-199
10361169-9	1999	Lactose hydrolysis in the presence of deoxycholic acid after the addition of dried liposome-entrapped beta-galactosidase to whole milk was proportional to the quantity of entrapped beta-galactosidase and the amount of dried liposomes added.	Deoxycholic Acid	38-54	galactosidase beta 1	Homo sapiens	102-120
10361169-9	1999	Lactose hydrolysis in the presence of deoxycholic acid after the addition of dried liposome-entrapped beta-galactosidase to whole milk was proportional to the quantity of entrapped beta-galactosidase and the amount of dried liposomes added.	Deoxycholic Acid	38-54	galactosidase beta 1	Homo sapiens	181-199
10361169-10	1999	These results demonstrate that beta-galactosidase entrapped in liposome is stable and reconstituted mostly upon rehydration, and can digest lactose in milk after the efficient lysis of liposomes in the presence of bile salts.	Lactose	140-147	galactosidase beta 1	Homo sapiens	31-49
10361169-10	1999	These results demonstrate that beta-galactosidase entrapped in liposome is stable and reconstituted mostly upon rehydration, and can digest lactose in milk after the efficient lysis of liposomes in the presence of bile salts.	Bile Acids and Salts	214-224	galactosidase beta 1	Homo sapiens	31-49
10232598-5	1999	In vitro infection of up to seven different epithelial cancer cell lines with Ad.DF3.betaGAL or Ad.DF3.BAX resulted in expression of either beta-galactosidase activity or HA-BAX protein, respectively, which was highly correlated with DF3 levels.	N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide	99-102	galactosidase beta 1	Homo sapiens	140-158
10320046-1	1999	Newly developed antiviral compounds consisting of an adamantane derivative chemically linked to a water-soluble polyanionic matrix were shown to inhibit HIV-1 infection in lymphoblastoid cells, HeLa CD4+ beta-galactosidase (MAGI) cells and macrophages.	Adamantane	53-63	galactosidase beta 1	Homo sapiens	204-222
10191024-8	1999	Here we present the development of the method and its application to a test system of beta-galactosidase adsorbed to methylated silica surfaces.	Silicon Dioxide	128-134	galactosidase beta 1	Homo sapiens	86-104
10320046-1	1999	Newly developed antiviral compounds consisting of an adamantane derivative chemically linked to a water-soluble polyanionic matrix were shown to inhibit HIV-1 infection in lymphoblastoid cells, HeLa CD4+ beta-galactosidase (MAGI) cells and macrophages.	Water	98-103	galactosidase beta 1	Homo sapiens	204-222
10447066-2	1999	Using LipofectAMINE, a widely used transfection reagent, we transfected 293T cells with a plasmid harboring the beta-galactosidase (beta-gal) gene.	Lipofectamine	6-19	galactosidase beta 1	Homo sapiens	112-130
10202154-6	1999	In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta-galactosidase expression in yeast by CBP co-expression, suggesting that NAD and CAD interact with CBP/p300 by a different mechanism.	CyADIC regimen	36-39	galactosidase beta 1	Homo sapiens	202-220
10447066-2	1999	Using LipofectAMINE, a widely used transfection reagent, we transfected 293T cells with a plasmid harboring the beta-galactosidase (beta-gal) gene.	Lipofectamine	6-19	galactosidase beta 1	Homo sapiens	112-120
10086997-3	1999	The ability of the EP3 receptor splice variants to modulate expression of a beta-galactosidase reporter gene under the control of a promoter containing cAMP response elements (CRE) was assessed.	Cyclic AMP	152-156	galactosidase beta 1	Homo sapiens	76-94
10086997-4	1999	Each splice variant induced sulprostone-mediated increase in beta-galactosidase enzymatic activity with EC50 ranging from 0.8 nM for the NT splice variant to 3.1 nM for the 77A splice variant.	sulprostone	28-39	galactosidase beta 1	Homo sapiens	61-79
9927065-7	1999	Immunofluorescence for beta-galactosidase demonstrated that TPA caused a significant increase in the percentage of beta-galactosidase-positive areas in 12:1 and 4:1 mixtures.	Tetradecanoylphorbol Acetate	60-63	galactosidase beta 1	Homo sapiens	115-133
10066732-9	1999	When human umbilical vein endothelial cells were cotransfected with beta-galactosidase, morphological analysis of stained cells revealed that cell death induction by overexpression of caspase-3 was completely suppressed in the presence of sodium nitroprusside, PAPA NONOate, or S-nitroso-L-cysteine (50 microM).	Nitroprusside	239-259	galactosidase beta 1	Homo sapiens	68-86
10066732-9	1999	When human umbilical vein endothelial cells were cotransfected with beta-galactosidase, morphological analysis of stained cells revealed that cell death induction by overexpression of caspase-3 was completely suppressed in the presence of sodium nitroprusside, PAPA NONOate, or S-nitroso-L-cysteine (50 microM).	S-nitrosocysteine	278-298	galactosidase beta 1	Homo sapiens	68-86
10605894-2	1999	It is based on the hydrolysis of lactulose to galactose and fructose by the enzyme beta-galactosidase immobilised in a reactor.	Lactulose	33-42	galactosidase beta 1	Homo sapiens	83-101
10605894-2	1999	It is based on the hydrolysis of lactulose to galactose and fructose by the enzyme beta-galactosidase immobilised in a reactor.	Galactose	46-55	galactosidase beta 1	Homo sapiens	83-101
10605894-2	1999	It is based on the hydrolysis of lactulose to galactose and fructose by the enzyme beta-galactosidase immobilised in a reactor.	Fructose	60-68	galactosidase beta 1	Homo sapiens	83-101
9918671-5	1999	By assaying release of beta-galactosidase upon cell death, it was possible to show that catalase transfection led to significant protection against the cytotoxic effect of increasing concentrations of hydrogen peroxide.	Hydrogen Peroxide	201-218	galactosidase beta 1	Homo sapiens	23-41
9949196-8	1999	This result initially suggested the presence of a third fucosyltransferase expressed in the COS cells but we have now shown that triantennary N- glycans with terminal nonreducing galactose units, similar to those present in asialo-fetuin, are modified by a weak endogenous beta-galactosidase in the COS cell extracts and thereby rendered suitable substrates for the alpha1,6-fucosyltransferase.	n- glycans	142-152	galactosidase beta 1	Homo sapiens	273-291
10026103-4	1999	We have shown by transient expression in HeLa cells of beta-galactosidase fusion proteins that the betaA subunit precursor contains a functional nuclear localization signal within the lysine-rich sequence corresponding to amino acids 231-244.	Lysine	184-190	galactosidase beta 1	Homo sapiens	55-73
9927065-7	1999	Immunofluorescence for beta-galactosidase demonstrated that TPA caused a significant increase in the percentage of beta-galactosidase-positive areas in 12:1 and 4:1 mixtures.	Tetradecanoylphorbol Acetate	60-63	galactosidase beta 1	Homo sapiens	23-41
9862854-8	1999	Transfection of luciferase or beta-galactosidase reporter genes complexed to AF-20-cholesteryl-spermine resulted in high levels of gene expression in AF-20 antigen-positive tumor cells.	cholesteryl-spermine	83-103	galactosidase beta 1	Homo sapiens	30-48
10323472-1	1999	A rapid and simple colorimetric method for the assay of urinary beta-galactosidase (GAL) and N-acetyl-beta-D-glucosaminidase (NAG) using 4-nitrophenyl-glycosides as the substrates and a Cobas Mire Auto-analyzer is described.	4-nitrophenyl-glycosides	137-161	galactosidase beta 1	Homo sapiens	64-82
9888444-5	1999	RESULTS: BrdU-beta-galactosidase double-staining revealed an inverse correlation between the number of BrdU-labeled nuclei and beta-galactosidase-labeled cells as a function of population doubling level (PDL).	Bromodeoxyuridine	9-13	galactosidase beta 1	Homo sapiens	14-32
9888444-5	1999	RESULTS: BrdU-beta-galactosidase double-staining revealed an inverse correlation between the number of BrdU-labeled nuclei and beta-galactosidase-labeled cells as a function of population doubling level (PDL).	Bromodeoxyuridine	9-13	galactosidase beta 1	Homo sapiens	127-145
10323472-1	1999	A rapid and simple colorimetric method for the assay of urinary beta-galactosidase (GAL) and N-acetyl-beta-D-glucosaminidase (NAG) using 4-nitrophenyl-glycosides as the substrates and a Cobas Mire Auto-analyzer is described.	4-nitrophenyl-glycosides	137-161	galactosidase beta 1	Homo sapiens	84-87
10029255-6	1999	Increased beta-galactosidase activity was found in 28.5% of patients taking valproate and 11.7% of patients taking carbamazepine compared with the results before treatment.	Valproic Acid	76-85	galactosidase beta 1	Homo sapiens	10-28
21380660-8	1999	Upon induction by IPTG (isopropyl-beta-D: -thio-galactopyranoside), the expressed beta-galactosidase could cleave X-gal (5-bromo-4-choloro-3-indoyl-beta-D: -galactopyranoside) and turn the colonies blue.	Isopropyl Thiogalactoside	18-22	galactosidase beta 1	Homo sapiens	82-100
21380660-8	1999	Upon induction by IPTG (isopropyl-beta-D: -thio-galactopyranoside), the expressed beta-galactosidase could cleave X-gal (5-bromo-4-choloro-3-indoyl-beta-D: -galactopyranoside) and turn the colonies blue.	Isopropyl Thiogalactoside	24-65	galactosidase beta 1	Homo sapiens	82-100
21380660-8	1999	Upon induction by IPTG (isopropyl-beta-D: -thio-galactopyranoside), the expressed beta-galactosidase could cleave X-gal (5-bromo-4-choloro-3-indoyl-beta-D: -galactopyranoside) and turn the colonies blue.	5-bromo-4-chloro-3-indolyl beta-galactoside	114-119	galactosidase beta 1	Homo sapiens	82-100
21380660-8	1999	Upon induction by IPTG (isopropyl-beta-D: -thio-galactopyranoside), the expressed beta-galactosidase could cleave X-gal (5-bromo-4-choloro-3-indoyl-beta-D: -galactopyranoside) and turn the colonies blue.	5-bromo-4-choloro-3-indoyl-beta-d: -galactopyranoside	121-174	galactosidase beta 1	Homo sapiens	82-100
10029255-6	1999	Increased beta-galactosidase activity was found in 28.5% of patients taking valproate and 11.7% of patients taking carbamazepine compared with the results before treatment.	Carbamazepine	115-128	galactosidase beta 1	Homo sapiens	10-28
9808856-4	1998	Other molecular changes are overexpression of matrix proteins, such as cellular fibronectin (cFN), and enhanced activity of beta-galactosidase at pH of 6.0 (senescence associated beta-Gal, or SA-beta-Gal).	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	192-203	galactosidase beta 1	Homo sapiens	124-142
10230039-0	1998	alpha-D-Glcp-(1&lt;--&gt;1)-beta-D-Galp-containing oligosaccharides, novel products from lactose by the action of beta-galactosidase.	alpha-d-glcp	0-12	galactosidase beta 1	Homo sapiens	114-132
10230039-0	1998	alpha-D-Glcp-(1&lt;--&gt;1)-beta-D-Galp-containing oligosaccharides, novel products from lactose by the action of beta-galactosidase.	Oligosaccharides	51-67	galactosidase beta 1	Homo sapiens	114-132
10230039-0	1998	alpha-D-Glcp-(1&lt;--&gt;1)-beta-D-Galp-containing oligosaccharides, novel products from lactose by the action of beta-galactosidase.	Lactose	89-96	galactosidase beta 1	Homo sapiens	114-132
10230039-1	1998	A mixture of oligosaccharides produced by beta-galactosidase using lactose as a substrate was fractionated according to degree of polymerization using gel filtration, followed by high-pH anion-exchange chromatography.	Oligosaccharides	13-29	galactosidase beta 1	Homo sapiens	42-60
10230039-1	1998	A mixture of oligosaccharides produced by beta-galactosidase using lactose as a substrate was fractionated according to degree of polymerization using gel filtration, followed by high-pH anion-exchange chromatography.	Lactose	67-74	galactosidase beta 1	Homo sapiens	42-60
9844002-2	1998	In this communication, we describe the isolation and characterization of a unique series of DtxR mutants that are constitutively active and repress the expression of beta-galactosidase from a diphtheria tox promoter/operator-lacZ transcriptional fusion, even in the absence of iron.	Iron	277-281	galactosidase beta 1	Homo sapiens	166-184
9844002-6	1998	Partial diploid analysis of strains carrying both native dtxR and alleles encoding either SAD2 or SAD3 demonstrate that these iron-independent mutants possess a positive dominant phenotype in the regulation of beta-galactosidase expression from a diphtheria tox promoter/operator-lacZ transcriptional fusion.	Iron	126-130	galactosidase beta 1	Homo sapiens	210-228
9826449-3	1998	coadministration of a model antigen (beta-galactosidase, beta-gal) with immunostimulatory sequence oligodeoxynucleotide (ISS-ODN) induces a mucosal IgA response equivalent to that induced by i.n.	Oligodeoxyribonucleotides	99-119	galactosidase beta 1	Homo sapiens	37-55
9870186-6	1998	beta-Galactosidase, in particular, showed greater activity with Good buffers than with phosphate or Tris buffers.	Phosphates	87-96	galactosidase beta 1	Homo sapiens	0-18
9870186-6	1998	beta-Galactosidase, in particular, showed greater activity with Good buffers than with phosphate or Tris buffers.	Tromethamine	100-104	galactosidase beta 1	Homo sapiens	0-18
9799717-2	1998	This protocol has been investigated for the coupling of five different enzymes, namely wheatgerm acid phosphatase, beta-glucosidase, beta-galactosidase, trypsin and xylanase, to an enteric methacrylate polymer Eudragit S-100.	methacrylate polymer eudragit s-100	189-224	galactosidase beta 1	Homo sapiens	133-151
9799717-8	1998	(2) In some cases, such as beta-glucosidase and beta-galactosidase, it might be necessary to remove excess carbodi-imide before the addition of the enzyme to the activated matrix.	Carbodiimides	107-120	galactosidase beta 1	Homo sapiens	48-66
9839388-5	1998	Lactulose was hydrolyzed to D-fructose and D-galactose by beta-gal.	Lactulose	0-9	galactosidase beta 1	Homo sapiens	58-66
9839388-5	1998	Lactulose was hydrolyzed to D-fructose and D-galactose by beta-gal.	Fructose	28-38	galactosidase beta 1	Homo sapiens	58-66
9839388-5	1998	Lactulose was hydrolyzed to D-fructose and D-galactose by beta-gal.	Galactose	43-54	galactosidase beta 1	Homo sapiens	58-66
9877207-4	1998	Transiently transfected ERalpha was able to activate expression of beta-galactosidase under the control of EREs in an oestradiol (E2)-dependent manner in both HeLa and HEK-293 cells.	Estradiol	118-128	galactosidase beta 1	Homo sapiens	67-85
9877207-4	1998	Transiently transfected ERalpha was able to activate expression of beta-galactosidase under the control of EREs in an oestradiol (E2)-dependent manner in both HeLa and HEK-293 cells.	Estradiol	130-132	galactosidase beta 1	Homo sapiens	67-85
9877207-6	1998	ERalpha/E2 also induced a two-fold potentiation of TPA-mediated expression of beta-galactosidase under the control of TREs in HeLa cells but not in HEK-293 cells.	Tetradecanoylphorbol Acetate	51-54	galactosidase beta 1	Homo sapiens	78-96
9922124-6	1998	In addition, H2O2-pretreatment of young cells induced an increase in GPx expression approaching old cell values and promoted also the premature appearance of neutral beta-galactosidase activity and decreased c-fos expression upon serum stimulation, both of which were assumed to be characteristic traits of the senescent phenotype.	Hydrogen Peroxide	13-17	galactosidase beta 1	Homo sapiens	166-184
9783354-2	1998	In the gastrointestinal tract, lactose is hydrolysed by the enzyme beta-galactosidase (lactase) into glucose and galactose.	Lactose	31-38	galactosidase beta 1	Homo sapiens	67-85
9783354-2	1998	In the gastrointestinal tract, lactose is hydrolysed by the enzyme beta-galactosidase (lactase) into glucose and galactose.	Glucose	101-108	galactosidase beta 1	Homo sapiens	67-85
9783354-2	1998	In the gastrointestinal tract, lactose is hydrolysed by the enzyme beta-galactosidase (lactase) into glucose and galactose.	Galactose	113-122	galactosidase beta 1	Homo sapiens	67-85
9930331-4	1998	In contrast, barium chloride-induced regeneration of muscle, injection of lipopolysaccharide, plasmid backbone or plasmid expressing a neo-antigen (beta-galactosidase) all generated widespread inflammation of injected muscle, with mononuclear infiltrate, comprised largely of macrophages and with both CD4+ and CD8+ T lymphocytes, present.	barium chloride	13-28	galactosidase beta 1	Homo sapiens	148-166
10052590-3	1998	By treatment of this oligosaccharide with neuraminidase and beta-galactosidase, we readily obtained an asialo-agalacto-biantennary heptasaccharide (GlcNAcbeta 1,2Manalpha1,6[GlcNAcbeta1,2Manalpha1,3]Manbeta1 ,4GlcNAcbeta1,4GlcNAc).	Xyloglucan Heptasaccharide	131-146	galactosidase beta 1	Homo sapiens	60-78
10052588-3	1998	Enzyme modification of glycans was demonstrated by separation of the products of hydrolysis of lactose hydrazone with beta-galactosidase, using hydroxybenzaldehyde-derivatized polystyrene beads.	Polysaccharides	23-30	galactosidase beta 1	Homo sapiens	118-136
10052590-3	1998	By treatment of this oligosaccharide with neuraminidase and beta-galactosidase, we readily obtained an asialo-agalacto-biantennary heptasaccharide (GlcNAcbeta 1,2Manalpha1,6[GlcNAcbeta1,2Manalpha1,3]Manbeta1 ,4GlcNAcbeta1,4GlcNAc).	glcnacbeta 1,2manalpha1	148-171	galactosidase beta 1	Homo sapiens	60-78
10052588-3	1998	Enzyme modification of glycans was demonstrated by separation of the products of hydrolysis of lactose hydrazone with beta-galactosidase, using hydroxybenzaldehyde-derivatized polystyrene beads.	lactose hydrazone	95-112	galactosidase beta 1	Homo sapiens	118-136
10052588-3	1998	Enzyme modification of glycans was demonstrated by separation of the products of hydrolysis of lactose hydrazone with beta-galactosidase, using hydroxybenzaldehyde-derivatized polystyrene beads.	4-hydroxybenzaldehyde	144-163	galactosidase beta 1	Homo sapiens	118-136
10052590-3	1998	By treatment of this oligosaccharide with neuraminidase and beta-galactosidase, we readily obtained an asialo-agalacto-biantennary heptasaccharide (GlcNAcbeta 1,2Manalpha1,6[GlcNAcbeta1,2Manalpha1,3]Manbeta1 ,4GlcNAcbeta1,4GlcNAc).	Oligosaccharides	21-36	galactosidase beta 1	Homo sapiens	60-78
11877223-2	1998	METHODS: Plasmid DNA with beta-galactosidase gene carried by lipofectin was applied to primary cultured human lens epithelial cells.	1,2-dielaidoylphosphatidylethanolamine	61-71	galactosidase beta 1	Homo sapiens	26-44
9766849-2	1998	Continuous exposure to estradiol enhanced the lipofectamine-mediated delivery of both pSV40-luciferase and pCMV beta-galactosidase in a concentration-dependent manner.	Estradiol	23-32	galactosidase beta 1	Homo sapiens	112-130
9766849-2	1998	Continuous exposure to estradiol enhanced the lipofectamine-mediated delivery of both pSV40-luciferase and pCMV beta-galactosidase in a concentration-dependent manner.	Lipofectamine	46-59	galactosidase beta 1	Homo sapiens	112-130
9766849-3	1998	Estradiol increased both the amount of pCMV beta-galactosidase per cell and the total fraction of cells competent to receive the transgene.	Estradiol	0-9	galactosidase beta 1	Homo sapiens	44-62
9721889-6	1998	TNP470 induced apoptosis and enhanced the expression of beta-galactosidase, a biomarker of senescence, which was partly mimicked by a nitric oxide (NO) donor S-nitroso-N-acetyl penicillamin.	Nitric Oxide	134-146	galactosidase beta 1	Homo sapiens	56-74
9712707-4	1998	In addition, the continued growth of two representative human cancer cell lines, U937 monoblastoid leukemia cells and HT29 colon adenocarcinoma cells, in the presence of nontoxic concentrations of EGCG showed life span limitations accompanied with telomere shortening, chromosomal abnormalities, and expression of the senescence-associated beta-galactosidase.	epigallocatechin gallate	197-201	galactosidase beta 1	Homo sapiens	340-358
9721889-6	1998	TNP470 induced apoptosis and enhanced the expression of beta-galactosidase, a biomarker of senescence, which was partly mimicked by a nitric oxide (NO) donor S-nitroso-N-acetyl penicillamin.	s-nitroso-n-acetyl penicillamin	158-189	galactosidase beta 1	Homo sapiens	56-74
9664682-1	1998	Recent studies in our laboratory have shown that chitosan, a polycationic polymer of glucosamine, can facilitate the transfection of HeLa cells with a plasmid that codes for beta-galactosidase.	Glucosamine	85-96	galactosidase beta 1	Homo sapiens	174-192
9675076-0	1998	2-Methoxyestradiol, an endogenous metabolite of estrogen, enhances apoptosis and beta-galactosidase expression in vascular endothelial cells.	2-Methoxyestradiol	0-18	galactosidase beta 1	Homo sapiens	81-99
9675076-4	1998	A nitric oxide (NO) donor S-nitroso-N-acetyl penicillamin (SNAP) also enhanced beta-galactosidase expression, suggesting a possible role of NO in mediating the action of 2ME.	Nitric Oxide	2-14	galactosidase beta 1	Homo sapiens	79-97
9675076-4	1998	A nitric oxide (NO) donor S-nitroso-N-acetyl penicillamin (SNAP) also enhanced beta-galactosidase expression, suggesting a possible role of NO in mediating the action of 2ME.	s-nitroso-n-acetyl penicillamin	26-57	galactosidase beta 1	Homo sapiens	79-97
9675076-4	1998	A nitric oxide (NO) donor S-nitroso-N-acetyl penicillamin (SNAP) also enhanced beta-galactosidase expression, suggesting a possible role of NO in mediating the action of 2ME.	snap	59-63	galactosidase beta 1	Homo sapiens	79-97
9721087-8	1998	X-Gal staining for beta-galactosidase activity was used to study gene transfer efficiency and distribution of the marker gene.	5-bromo-4-chloro-3-indolyl beta-galactoside	0-5	galactosidase beta 1	Homo sapiens	19-37
9674704-9	1998	This extended growth capacity appears to be associated with a methylation phenomenon since treatment of these cells with the methylation inhibitor 5-aza-2-deoxycytidine resulted in growth arrest concurrent with reacquisition of p16 expression and senescence associated beta-galactosidase.	Decitabine	147-168	galactosidase beta 1	Homo sapiens	269-287
9703249-4	1998	The two final preparations contained beta-galactosidase activity and showed three protein components of 64, 30, and 21 kDa with sodium dodecyl sulfate-polyacrylamide gel electrophoresis, which are derived from the beta-galactosidase multimer.	Sodium Dodecyl Sulfate	128-150	galactosidase beta 1	Homo sapiens	214-232
9703249-4	1998	The two final preparations contained beta-galactosidase activity and showed three protein components of 64, 30, and 21 kDa with sodium dodecyl sulfate-polyacrylamide gel electrophoresis, which are derived from the beta-galactosidase multimer.	polyacrylamide	151-165	galactosidase beta 1	Homo sapiens	214-232
9637772-3	1998	beta-Galactosidase activity was detected by light microscopy using the chromogenic substrate 5-bromo-4-chloro-3-indolyl beta-d-galactopyranoside.	5-bromo-4-chloro-3-indolyl beta-galactoside	93-144	galactosidase beta 1	Homo sapiens	0-18
9725796-2	1998	Beta-galactosidase plasmid showed expression rates of 2-5% of muscle fibers with or without pretreatments using bupivacaine or cardiotoxin facilitators 1 or 5 days earlier, respectively.	Bupivacaine	112-123	galactosidase beta 1	Homo sapiens	0-18
9548772-0	1998	Model system for heat-induced translocation of cytoplasmic beta-galactosidase across phospholipid bilayer membrane.	phospholipid bilayer	85-105	galactosidase beta 1	Homo sapiens	59-77
9585685-1	1998	An 18-month-old girl was diagnosed as having GM1 gangliosidosis, on the basis of the clinical symptoms of muscle stiffness, developmental retardation, hepatosplenomegaly, and kyphoscoliosis and a laboratory study that revealed a deficiency in the lysosomal degradative enzyme beta-galactosidase.	G(M1) Ganglioside	45-48	galactosidase beta 1	Homo sapiens	276-294
9548772-1	1998	The possibility of the translocation of the enzyme across the phospholipid bilayer membrane was investigated by using the liposomes prepared by 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) in which beta-galactosidase (beta-gal) was entrapped.	Phospholipids	62-74	galactosidase beta 1	Homo sapiens	209-227
9548772-1	1998	The possibility of the translocation of the enzyme across the phospholipid bilayer membrane was investigated by using the liposomes prepared by 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) in which beta-galactosidase (beta-gal) was entrapped.	Phospholipids	62-74	galactosidase beta 1	Homo sapiens	209-217
9548772-1	1998	The possibility of the translocation of the enzyme across the phospholipid bilayer membrane was investigated by using the liposomes prepared by 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) in which beta-galactosidase (beta-gal) was entrapped.	1-palmitoyl-2-oleoylphosphatidylcholine	144-192	galactosidase beta 1	Homo sapiens	209-227
9548772-1	1998	The possibility of the translocation of the enzyme across the phospholipid bilayer membrane was investigated by using the liposomes prepared by 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) in which beta-galactosidase (beta-gal) was entrapped.	1-palmitoyl-2-oleoylphosphatidylcholine	144-192	galactosidase beta 1	Homo sapiens	209-217
9852273-4	1998	A mixture of ethanol and polyethylene glycol (45:55) at a concentration of 1% produced less pronounced improvements in transgene delivery to MCF-7 cells (a 70% increase in SV-40-luciferase uptake and a 4-fold increase in CMV-beta-galactosidase uptake) but no improvement in SV-40-luciferase gene delivery to MDA-MB-231 cells.	Ethanol	13-20	galactosidase beta 1	Homo sapiens	225-243
9852273-4	1998	A mixture of ethanol and polyethylene glycol (45:55) at a concentration of 1% produced less pronounced improvements in transgene delivery to MCF-7 cells (a 70% increase in SV-40-luciferase uptake and a 4-fold increase in CMV-beta-galactosidase uptake) but no improvement in SV-40-luciferase gene delivery to MDA-MB-231 cells.	Polyethylene Glycols	25-44	galactosidase beta 1	Homo sapiens	225-243
9535275-1	1998	M15 beta-Galactosidase was activated by heat-denatured wild-type beta-galactosidase, urea, and heat-denatured wild-type beta-galactosidase, a peptide made up of residues 6-44 of beta-galactosidase and CB2, the peptide that is normally used for complementation (residues 3-92 of beta-galactosidase).	Urea	85-89	galactosidase beta 1	Homo sapiens	4-22
9472004-3	1998	Here we show that treatment of fibroblasts with 8-methoxypsoralen (8-MOP) and subsequent ultraviolet A (UVA) irradiation resulted in a permanent switch of mitotic to stably postmitotic fibroblasts which acquired a high level of de novo expression of SA-beta-galactosidase, a marker for fibroblast senescence in vitro and in vivo.	Methoxsalen	48-65	galactosidase beta 1	Homo sapiens	253-271
9535275-6	1998	Beta-galactosidase denatured by both urea and heat resulted in a streak of interacting protein on the native PAGE.	Urea	37-41	galactosidase beta 1	Homo sapiens	0-18
9430704-3	1998	We demonstrate that the Tat-NLS, not recognized by importin 58/97 subunits as shown using an enzyme-linked immunosorbent assay-based binding assay, is sufficient to target the 476-kDa heterologous beta-galactosidase protein to the nucleus in ATP-dependent but cytosolic factor-independent fashion.	Adenosine Triphosphate	242-245	galactosidase beta 1	Homo sapiens	197-215
9457900-8	1998	In situ staining of beta-gal-positive cells using X-gal as substrate revealed that low-dose irradiation did not increase the overall level of induction of beta-gal but increased the number of cells capable of inducing beta-gal in response to heat shock.	5-bromo-4-chloro-3-indolyl beta-galactoside	50-55	galactosidase beta 1	Homo sapiens	20-28
9536269-3	1998	We have therefore assessed the effect of CF sputum on the expression of the reporter gene beta-galactosidase complexed with the cationic liposome DC-Chol/DOPE in a number of cell lines in vitro.	3-(N-(N',N'-dimethylaminoethane)carbamoyl)cholesterol	146-153	galactosidase beta 1	Homo sapiens	90-108
9435242-1	1998	Human protective protein/cathepsin A (PPCA), a serine carboxypeptidase, forms a multienzyme complex with beta-galactosidase and neuraminidase and is required for the intralysosomal activity and stability of these two glycosidases.	Serine	47-53	galactosidase beta 1	Homo sapiens	105-123
9648244-6	1998	Moreover, the presence of a 3"-O-sulfate group not only increases the water solubility tremendously, but also protects the substrate from cleavage by exo-beta-galactosidase as the 6"-O-benzyl group in 2 does.	3"-o-sulfate	28-40	galactosidase beta 1	Homo sapiens	154-172
9648244-6	1998	Moreover, the presence of a 3"-O-sulfate group not only increases the water solubility tremendously, but also protects the substrate from cleavage by exo-beta-galactosidase as the 6"-O-benzyl group in 2 does.	Water	70-75	galactosidase beta 1	Homo sapiens	154-172
9536269-3	1998	We have therefore assessed the effect of CF sputum on the expression of the reporter gene beta-galactosidase complexed with the cationic liposome DC-Chol/DOPE in a number of cell lines in vitro.	dioleoyl phosphatidylethanolamine	154-158	galactosidase beta 1	Homo sapiens	90-108
9362504-5	1997	Nuclear localization of glypican beta-galactosidase or Fc fusion proteins in transfected 293 cells and C6 glioma cells was greatly reduced or abolished after mutation of the basic amino acids or deletion of the sequence containing the nuclear localization signal, and no nuclear staining was seen in the case of heparan sulfate and chondroitin sulfate proteoglycans that do not possess a nuclear localization signal, such as syndecan-3 or decorin (which is closely related in structure to biglycan).	Amino Acids, Basic	174-191	galactosidase beta 1	Homo sapiens	33-51
9440810-6	1998	A 48.2-fold stimulation of beta-galactosidase activity was observed in the presence of 10(-10) M 1,25-(OH)2D3.	Calcitriol	97-109	galactosidase beta 1	Homo sapiens	27-45
9467238-2	1997	In the gastrointestinal tract, lactose is hydrolysed by the enzyme beta-galactosidase (lactase) into glucose and galactose.	Lactose	31-38	galactosidase beta 1	Homo sapiens	67-85
9467238-2	1997	In the gastrointestinal tract, lactose is hydrolysed by the enzyme beta-galactosidase (lactase) into glucose and galactose.	Glucose	101-108	galactosidase beta 1	Homo sapiens	67-85
9467238-2	1997	In the gastrointestinal tract, lactose is hydrolysed by the enzyme beta-galactosidase (lactase) into glucose and galactose.	Galactose	113-122	galactosidase beta 1	Homo sapiens	67-85
9398819-4	1997	There was a significantly greater reduction in lactose concentrations at pH 6.7 than that at either pH 6.2 or pH 5.7, accompanied by the highest beta-galactosidase activity and D-lactate production.	Lactose	47-54	galactosidase beta 1	Homo sapiens	145-163
22358881-0	1997	Effect of hypoxia duration on the oxygen-dependent production of a recombinant protein, beta-galactosidase, by an animal cell line, F6D2, with a hypoxia-inducible enhancer.	Oxygen	34-40	galactosidase beta 1	Homo sapiens	88-106
22358881-8	1997	The effects of hypoxic duration as well as oxygen concentration on the beta-galactosidase production were successfully predicated by the model.	Oxygen	43-49	galactosidase beta 1	Homo sapiens	71-89
9414969-9	1997	In the lactose group, but not in the sucrose group, faecal beta-galactosidase activity increased, pH dropped, and breath H2 excretion decreased.	Lactose	7-14	galactosidase beta 1	Homo sapiens	59-77
9286159-4	1997	The enzyme beta-galactosidase (beta-Gal) was assayed using resorufin beta-D-galactopyranoside (RBG), a substrate that is hydrolyzed to resorufin, a fluorescent product.	resorufin galactopyranoside	59-93	galactosidase beta 1	Homo sapiens	11-29
9343682-0	1997	Safranin O counter-staining enhances the counting of beta-galactosidase-expressing cells.	phenosafranine	0-10	galactosidase beta 1	Homo sapiens	53-71
9361203-8	1997	The beta-galactosidase activity of all strains decreased rapidly once the fermented milk was stored at 4 degrees C. Strain JB10, originating in the stomach contents of the piglets, had properties that were useful for the manufacture of fermented milk products for lactose-intolerant humans.	Lactose	264-271	galactosidase beta 1	Homo sapiens	4-22
9361203-9	1997	Milk fermented by this strain had a lactose concentration of about 4.0% and contained 6.6 x 10(6) cfu/ml after storage at 4 degrees C for 20 d. Strain JB10 produced a beta-galactosidase that was active at pH 5.5 (35% of the activity at pH 7.0) and was not inhibited by the presence of bile acids in the culture medium.	Lactose	36-43	galactosidase beta 1	Homo sapiens	167-185
9361203-9	1997	Milk fermented by this strain had a lactose concentration of about 4.0% and contained 6.6 x 10(6) cfu/ml after storage at 4 degrees C for 20 d. Strain JB10 produced a beta-galactosidase that was active at pH 5.5 (35% of the activity at pH 7.0) and was not inhibited by the presence of bile acids in the culture medium.	Bile Acids and Salts	285-295	galactosidase beta 1	Homo sapiens	167-185
9403006-2	1997	One is the herpes simplex virus type 1 thymidine kinase gene (HSV-TK) which induces sensitivity to ganciclovir, and the second is the bacterial beta-galactosidase gene (LacZ) which was revealed by an histochemical staining with 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-Gal).	Ganciclovir	99-110	galactosidase beta 1	Homo sapiens	144-162
9403006-2	1997	One is the herpes simplex virus type 1 thymidine kinase gene (HSV-TK) which induces sensitivity to ganciclovir, and the second is the bacterial beta-galactosidase gene (LacZ) which was revealed by an histochemical staining with 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-Gal).	5-bromo-4-chloro-3-indolyl beta-galactoside	228-279	galactosidase beta 1	Homo sapiens	144-162
9403006-2	1997	One is the herpes simplex virus type 1 thymidine kinase gene (HSV-TK) which induces sensitivity to ganciclovir, and the second is the bacterial beta-galactosidase gene (LacZ) which was revealed by an histochemical staining with 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-Gal).	5-bromo-4-chloro-3-indolyl beta-galactoside	281-286	galactosidase beta 1	Homo sapiens	144-162
9299022-2	1997	[Ru(bpy)2(phen-mi)]2+ was covalently linked to human serum albumin, immunoglobulin G, and beta-galactosidase.	(ruthenium (2,2'-bipyridine)2(1,10-phenanthroline-5-maleimide))(PF6)2	0-21	galactosidase beta 1	Homo sapiens	90-108
22358769-5	1997	Following retinoic acid treatment, RAd35 infected cell lines ND7/23, NG108 and NTera2, showed beta-galactosidase expression in up to 90% of the cells.	Tretinoin	10-23	galactosidase beta 1	Homo sapiens	94-112
9286159-4	1997	The enzyme beta-galactosidase (beta-Gal) was assayed using resorufin beta-D-galactopyranoside (RBG), a substrate that is hydrolyzed to resorufin, a fluorescent product.	resorufin galactopyranoside	59-93	galactosidase beta 1	Homo sapiens	31-39
9286159-4	1997	The enzyme beta-galactosidase (beta-Gal) was assayed using resorufin beta-D-galactopyranoside (RBG), a substrate that is hydrolyzed to resorufin, a fluorescent product.	resorufin galactopyranoside	95-98	galactosidase beta 1	Homo sapiens	11-29
9286159-4	1997	The enzyme beta-galactosidase (beta-Gal) was assayed using resorufin beta-D-galactopyranoside (RBG), a substrate that is hydrolyzed to resorufin, a fluorescent product.	resorufin galactopyranoside	95-98	galactosidase beta 1	Homo sapiens	31-39
9286159-9	1997	The relative inhibition of beta-Gal by lactose, p-hydroxymercuribenzoic acid, and PETG was determined by varying the inhibitor concentration with constant enzyme and substrate concentration.	Lactose	39-46	galactosidase beta 1	Homo sapiens	27-35
9286159-9	1997	The relative inhibition of beta-Gal by lactose, p-hydroxymercuribenzoic acid, and PETG was determined by varying the inhibitor concentration with constant enzyme and substrate concentration.	4-hydroxymercuribenzoate	48-76	galactosidase beta 1	Homo sapiens	27-35
9286159-9	1997	The relative inhibition of beta-Gal by lactose, p-hydroxymercuribenzoic acid, and PETG was determined by varying the inhibitor concentration with constant enzyme and substrate concentration.	petg	82-86	galactosidase beta 1	Homo sapiens	27-35
9242510-0	1997	CD44 substituted with heparan sulfate and endo-beta-galactosidase-sensitive oligosaccharides: a major proteoglycan in adult human epidermis.	Oligosaccharides	76-92	galactosidase beta 1	Homo sapiens	47-65
9277436-8	1997	Fluorescein-labeled C1315 peptide labeled 9-31% of Hep G2 (high), 10-14% of HuH7, and 0.6-3.4% of Hep G2 (low) cells, and when the lac Z gene was transfected, only these cells expressed beta-galactosidase.	Fluorescein	0-11	galactosidase beta 1	Homo sapiens	186-204
9242510-8	1997	Five to 33% of 35SO4 and 26-37% of [3H]glucosamine, however, was released by endo-beta-galactosidase, implying marked substitution by oligosaccharides with N-acetyllactosamine repeats.	35so4	15-20	galactosidase beta 1	Homo sapiens	82-100
9242510-8	1997	Five to 33% of 35SO4 and 26-37% of [3H]glucosamine, however, was released by endo-beta-galactosidase, implying marked substitution by oligosaccharides with N-acetyllactosamine repeats.	Tritium	35-39	galactosidase beta 1	Homo sapiens	82-100
9242510-8	1997	Five to 33% of 35SO4 and 26-37% of [3H]glucosamine, however, was released by endo-beta-galactosidase, implying marked substitution by oligosaccharides with N-acetyllactosamine repeats.	Glucosamine	39-50	galactosidase beta 1	Homo sapiens	82-100
9242510-8	1997	Five to 33% of 35SO4 and 26-37% of [3H]glucosamine, however, was released by endo-beta-galactosidase, implying marked substitution by oligosaccharides with N-acetyllactosamine repeats.	Oligosaccharides	134-150	galactosidase beta 1	Homo sapiens	82-100
9242510-9	1997	Heparitinase pretreatment retarded, whereas endo-beta-galactosidase enhanced the mobility of the &gt; or = 180-kDa polydisperse CD44 on agarose gel electrophoresis.	Sepharose	136-143	galactosidase beta 1	Homo sapiens	49-67
9242510-14	1997	Both the large and the 100-kDa variant of epidermal CD44 contain endo-beta-galactosidase-sensitive oligosaccharides not previously noted in other cells or tissues.	Oligosaccharides	99-115	galactosidase beta 1	Homo sapiens	70-88
18636484-1	1997	Large phosphatydilcholine unilamellar vesicles appear to be suitable controlled and protective delivery systems of beta-galactosidase.	phosphatydilcholine	6-25	galactosidase beta 1	Homo sapiens	115-133
9221748-9	1997	Similarly, this IL-1beta- and TNF-alpha-induced formation of active 11beta-hydroxy glucocorticosteroids from inert 11-keto glucocorticosteroids by the 11beta-OHSD1 was shown in the Kiki cell line that expresses the stably transfected bacterial beta-galactosidase gene under the control of a glucocorticosteroids response element.	11beta-hydroxy glucocorticosteroids	68-103	galactosidase beta 1	Homo sapiens	244-262
9221748-9	1997	Similarly, this IL-1beta- and TNF-alpha-induced formation of active 11beta-hydroxy glucocorticosteroids from inert 11-keto glucocorticosteroids by the 11beta-OHSD1 was shown in the Kiki cell line that expresses the stably transfected bacterial beta-galactosidase gene under the control of a glucocorticosteroids response element.	glucocorticosteroids	83-103	galactosidase beta 1	Homo sapiens	244-262
9269576-4	1997	The binding was effectively inhibited by saccharide chains of band 3, a major glycoprotein of human erythrocytes, and lowered when the saccharide chains of band 3 were removed from the cell surface by pretreatment of the cells with endo-beta-galactosidase which specifically cleaves the polylactosaminyl saccharide chains of band 3.	Carbohydrates	41-51	galactosidase beta 1	Homo sapiens	237-255
9269576-4	1997	The binding was effectively inhibited by saccharide chains of band 3, a major glycoprotein of human erythrocytes, and lowered when the saccharide chains of band 3 were removed from the cell surface by pretreatment of the cells with endo-beta-galactosidase which specifically cleaves the polylactosaminyl saccharide chains of band 3.	polylactosaminyl saccharide	287-314	galactosidase beta 1	Homo sapiens	237-255
9231067-2	1997	Using N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTMA) combined with Tween 80 as a carrier system and cDNA of luciferase or beta-galactosidase gene as a reporter, we investigated the importance of DOTMA to DNA ratio and the ratio of DOTMA to Tween 80 in the lipid formulation in determining the site and level of transgene expression following intravenous administration.	N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium	70-75	galactosidase beta 1	Homo sapiens	146-164
9279558-2	1997	In addition, GSA-II staining following endo-beta-galactosidase digestion procedure was also applied.	gsa-ii	13-19	galactosidase beta 1	Homo sapiens	44-62
9279558-7	1997	Reactivity with GSA-II staining following endo-beta-galactosidase digestion, which recognizes linear poly-N-acetyllactosamine structures, was found in a few malignant cells from 21 individuals.	gsa	16-19	galactosidase beta 1	Homo sapiens	47-65
9279558-7	1997	Reactivity with GSA-II staining following endo-beta-galactosidase digestion, which recognizes linear poly-N-acetyllactosamine structures, was found in a few malignant cells from 21 individuals.	poly-N-acetyllactosamine	101-125	galactosidase beta 1	Homo sapiens	47-65
9220339-5	1997	RA, both, in the all-trans and in the 9-cis configuration resulted in a significant acceleration of cardiomyocyte differentiation and a transient increase of beta-galactosidase activity.	Tretinoin	0-2	galactosidase beta 1	Homo sapiens	158-176
9203065-1	1997	Three unrelated North American cases with slowly progressive forms of GM1 gangliosidosis were found to have two unique point mutations and a 9 bp insertion in the coding region of the gene encoding beta-galactosidase.	G(M1) Ganglioside	70-73	galactosidase beta 1	Homo sapiens	198-216
9220339-6	1997	To test whether this acceleration of cardiac differentiation and RA-induced increase of the MLC-2v promotor/beta-galactosidase activity reflects an increase of cardiac- and ventricle-specific gene expression, a semi-quantitative RT-PCR analysis was performed for alpha-cardiac myosin heavy chain (alpha-MHC) and MLC-2v genes.	Tretinoin	65-67	galactosidase beta 1	Homo sapiens	108-126
9201723-4	1997	Mutation of the palmitoylation site (cysteine-3) within Fyn16-beta-galactosidase or wild-type Fyn abrogated plasma membrane localization, resulting in redistribution of the mutant proteins into intracellular membranes.	Cysteine	37-45	galactosidase beta 1	Homo sapiens	62-80
9083046-4	1997	Addition of biotin (an activator of guanylate cyclase) induced the expression of beta-galactosidase present as a chimeric plasmid containing the H2b 187-nucleotide 5"-UTR.	Biotin	12-18	galactosidase beta 1	Homo sapiens	81-99
18634086-5	1997	Inducing single-cell suspension with dextran sulfate, a highly sulfated polyanion, resulted in a four-fold increase in volumetric yield of the recombinant glycosylated protein, human secreted alkaline phosphatase, and a two-fold increase in volumetric yield of the recombinant cytoplasmic protein, beta-galactosidase.	Dextran Sulfate	37-52	galactosidase beta 1	Homo sapiens	298-316
18634086-8	1997	2.3 g/L) for beta-galactosidase under elevated oxygen have been obtained.	Oxygen	47-53	galactosidase beta 1	Homo sapiens	13-31
9171933-14	1997	In both cases there was strong evidence for transfer of reporter genes (neo and LacZ) into the myeloma clone: morphologically abnormal G418-resistant colonies demonstrated intense staining for beta-galactosidase, and cytospin preparations showed 100% plasma cells with monoclonal heavy and light chain restriction.	antibiotic G 418	135-139	galactosidase beta 1	Homo sapiens	193-211
9165533-7	1997	The N-acyl-(diaminobutyric acid)n derivatives were the most potent transfecting agents among those tested and induced a beta-galactosidase activity 2 to 20 times higher than the N-acyl-lysine, -ornithine or -diaminopropionic acid derivatives.	n-acyl-(diaminobutyric acid)n	4-33	galactosidase beta 1	Homo sapiens	120-138
9104037-8	1997	Parameter sensitivity analysis indicates the importance of key parameters to lac operon expression and cell growth: the lactose and allolactose transformation rates by beta-galactosidase and the glucose concentrations that affect catabolite repression and inducer exclusion.	Lactose	120-127	galactosidase beta 1	Homo sapiens	168-186
9056256-5	1997	The binding was inhibited by band 3 and its oligosaccharides but not by the oligosaccharides pretreated with endo-beta-galactosidase, an enzyme specifically cleaves poly-N-acetyllactosaminyl saccharide chains of band 3.	poly-n-acetyllactosaminyl saccharide	165-201	galactosidase beta 1	Homo sapiens	114-132
9056256-6	1997	When erythrocytes were pretreated with endo-beta-galactosidase to remove poly-N-acetyllactosaminyl saccharide chains from cell surface prior to acridine orange treatment, the cells did not become susceptible to anti-band 3 binding.	poly-n-acetyllactosaminyl saccharide	73-109	galactosidase beta 1	Homo sapiens	44-62
9056256-6	1997	When erythrocytes were pretreated with endo-beta-galactosidase to remove poly-N-acetyllactosaminyl saccharide chains from cell surface prior to acridine orange treatment, the cells did not become susceptible to anti-band 3 binding.	Acridine Orange	144-159	galactosidase beta 1	Homo sapiens	44-62
9134730-2	1997	Hydrophobically modified dextrans, benzoyl dextran and valeryl dextran, have been used to study the interactions between tryptophan residues and benzoyl or valeryl groups by partitioning of tryptophan, tryptophan-tryptophan, (tryptophan)3, poly(lysine, tryptophan), beta-galactosidase and lysozyme in polymer aqueous two-phase systems.	Dextrans	25-33	galactosidase beta 1	Homo sapiens	266-284
9134730-2	1997	Hydrophobically modified dextrans, benzoyl dextran and valeryl dextran, have been used to study the interactions between tryptophan residues and benzoyl or valeryl groups by partitioning of tryptophan, tryptophan-tryptophan, (tryptophan)3, poly(lysine, tryptophan), beta-galactosidase and lysozyme in polymer aqueous two-phase systems.	valeryl dextran	55-70	galactosidase beta 1	Homo sapiens	266-284
9149388-3	1997	These GM1 derivatives could be hydrolyzed to the corresponding GM3 derivatives by treatment with GM1-beta-galactosidase and beta-hexosaminidases.	G(M1) Ganglioside	6-9	galactosidase beta 1	Homo sapiens	101-119
9149388-3	1997	These GM1 derivatives could be hydrolyzed to the corresponding GM3 derivatives by treatment with GM1-beta-galactosidase and beta-hexosaminidases.	gm3	63-66	galactosidase beta 1	Homo sapiens	101-119
9149388-3	1997	These GM1 derivatives could be hydrolyzed to the corresponding GM3 derivatives by treatment with GM1-beta-galactosidase and beta-hexosaminidases.	G(M1) Ganglioside	97-100	galactosidase beta 1	Homo sapiens	101-119
9077140-2	1997	beta-galactosidase reporter activity was inducible by adding Zn2+ ions to the medium (100 microM for 2-4 h).	Zinc	61-65	galactosidase beta 1	Homo sapiens	0-18
9073553-1	1997	A serum glycoprotein, Gc protein (vitamin D3-binding protein), can be converted by beta-galactosidase of B cells and sialidase of T cells to a potent macrophage-activating factor (MAF), a protein with N-acetylgalactosamine as the remaining sugar moiety.	Acetylgalactosamine	201-222	galactosidase beta 1	Homo sapiens	83-101
9073553-1	1997	A serum glycoprotein, Gc protein (vitamin D3-binding protein), can be converted by beta-galactosidase of B cells and sialidase of T cells to a potent macrophage-activating factor (MAF), a protein with N-acetylgalactosamine as the remaining sugar moiety.	Sugars	240-245	galactosidase beta 1	Homo sapiens	83-101
9073609-4	1997	The yeast transformants used in this study contained the human estrogen, androgen, or progesterone receptor along with the appropriate steroid responsive elements upstream of the beta-galactosidase reporter gene.	Steroids	135-142	galactosidase beta 1	Homo sapiens	179-197
8970963-2	1996	A reporter gene, the bacterial lacZ gene, which expressed beta-galactosidase, was inserted into the multiple cloning site of pH300 to make pH300-lac.	ph300	125-130	galactosidase beta 1	Homo sapiens	58-76
9020114-4	1997	By measuring the synthesis of OppA or beta-galactosidase from these mRNAs, we found that the 171-nucleotide 5"-untranslated region and 145 nucleotides of the ORF of OppA mRNA are involved in the polyamine stimulation of OppA synthesis.	oppa	165-169	galactosidase beta 1	Homo sapiens	38-56
9020114-4	1997	By measuring the synthesis of OppA or beta-galactosidase from these mRNAs, we found that the 171-nucleotide 5"-untranslated region and 145 nucleotides of the ORF of OppA mRNA are involved in the polyamine stimulation of OppA synthesis.	Polyamines	195-204	galactosidase beta 1	Homo sapiens	38-56
9020114-4	1997	By measuring the synthesis of OppA or beta-galactosidase from these mRNAs, we found that the 171-nucleotide 5"-untranslated region and 145 nucleotides of the ORF of OppA mRNA are involved in the polyamine stimulation of OppA synthesis.	oppa	165-169	galactosidase beta 1	Homo sapiens	38-56
9025902-4	1997	beta-Galactosidase protein is readily internalized by adherent cell lines when incorporated into a calcium phosphate precipitate; significant enzyme activity can be recovered up to 72 h after transfection.	calcium phosphate	99-116	galactosidase beta 1	Homo sapiens	0-18
8943957-5	1996	After infection with RAd35 beta-Gal at 30, 100, and 1000 plaque-forming units per cell (pfu/cell), expression of beta-galactosidase was augmented up to 17-, 19-, and 23-fold, respectively, in human VSMCs treated with forskolin and phorbol ester compared with unstimulated cells.	Colforsin	217-226	galactosidase beta 1	Homo sapiens	113-131
8943957-5	1996	After infection with RAd35 beta-Gal at 30, 100, and 1000 plaque-forming units per cell (pfu/cell), expression of beta-galactosidase was augmented up to 17-, 19-, and 23-fold, respectively, in human VSMCs treated with forskolin and phorbol ester compared with unstimulated cells.	Phorbol Esters	231-244	galactosidase beta 1	Homo sapiens	113-131
9090722-3	1997	The polymers containing oxirane and aldehyde groups were promising for direct binding of beta-galactosidase, whereas the supports containing amino groups also qualified for enzyme immobilization with glutaraldehyde.	Polymers	4-12	galactosidase beta 1	Homo sapiens	89-107
9090722-3	1997	The polymers containing oxirane and aldehyde groups were promising for direct binding of beta-galactosidase, whereas the supports containing amino groups also qualified for enzyme immobilization with glutaraldehyde.	Ethylene Oxide	24-31	galactosidase beta 1	Homo sapiens	89-107
9090722-3	1997	The polymers containing oxirane and aldehyde groups were promising for direct binding of beta-galactosidase, whereas the supports containing amino groups also qualified for enzyme immobilization with glutaraldehyde.	Aldehydes	36-44	galactosidase beta 1	Homo sapiens	89-107
14646553-2	1997	X-gal staining showed 100% infectivity of the cell cultures and high-level expression of bacterial beta-galactosidase in these cells.	5-bromo-4-chloro-3-indolyl beta-galactoside	0-5	galactosidase beta 1	Homo sapiens	99-117
8915596-1	1996	Lipofectamine-based transfection was used as a method of choice to deliver the bacterial beta-galactosidase gene into human central nervous system (CNS) precursor cells.	Lipofectamine	0-13	galactosidase beta 1	Homo sapiens	89-107
8910459-8	1996	Gel filtration analysis of fibroblast extracts of patients deficient in either beta-galactosidase (beta-galactosidosis) or cathepsin A (galactosialidosis), which accumulate KS, demonstrates that the 1.27-MDa complex is disrupted and that GALNS is present only in free homodimeric form.	Keratan Sulfate	173-175	galactosidase beta 1	Homo sapiens	79-97
8812744-3	1996	ST-PA/mAbs complexes could efficiently deliver biotinylated beta-galactosidase into a variety of cancer cell lines through molecules expressed on their surface.	st-pa	0-5	galactosidase beta 1	Homo sapiens	60-78
8787727-2	1996	The chemiluminescence detection systems for beta-galactosidase, beta-glucuronidase (GUS), and secreted placental alkaline phosphatase (SEAP) reporter enzymes are all based on use of 1,2-dioxetane substrates.	1,2-dioxetane	182-195	galactosidase beta 1	Homo sapiens	44-62
8694025-2	1996	The initial study with nine lactose maldigesters showed a threefold increase in fecal beta-galactosidase activity after 16 d of lactose feeding.	Lactose	28-35	galactosidase beta 1	Homo sapiens	86-104
8694025-2	1996	The initial study with nine lactose maldigesters showed a threefold increase in fecal beta-galactosidase activity after 16 d of lactose feeding.	Lactose	128-135	galactosidase beta 1	Homo sapiens	86-104
8837443-0	1996	Evaluation of cyclohexenoesculetin-beta-D-galactoside and 8-hydroxyquinoline-beta-D-galactoside as substrates for the detection of beta-galactosidase.	cyclohexenoesculetin-beta-d-galactoside	14-53	galactosidase beta 1	Homo sapiens	131-149
8837443-0	1996	Evaluation of cyclohexenoesculetin-beta-D-galactoside and 8-hydroxyquinoline-beta-D-galactoside as substrates for the detection of beta-galactosidase.	8-hydroxyquinoline-beta-d-galactoside	58-95	galactosidase beta 1	Homo sapiens	131-149
8889826-6	1996	However, elimination of peripheral sialic acid and galactose residues by sequential treatment with neuraminidase and beta-galactosidase gave clear mass spectra with several sharp peaks.	N-Acetylneuraminic Acid	35-46	galactosidase beta 1	Homo sapiens	117-135
8889826-6	1996	However, elimination of peripheral sialic acid and galactose residues by sequential treatment with neuraminidase and beta-galactosidase gave clear mass spectra with several sharp peaks.	Galactose	51-60	galactosidase beta 1	Homo sapiens	117-135
8798260-1	1996	Local delivery of Escherichia coli beta-galactosidase gene (beta-gal) to surfactant protein-A (SP-A)-producing cells by a replication-defective recombinant adenovirus (AdCMV.beta-gal) was tested in human 8-12-wk-old fetal lung explants cultured in Waymouth"s medium.	waymouth"s medium	248-265	galactosidase beta 1	Homo sapiens	35-43
8842983-7	1996	Monolayers of RRBC pre-treated with alpha-galactosidase was not reactive while in monolayers treated with beta-galactosidase, the anti-gal reactivity was comparable to those in untreated RRBC monolayer, thus indicating the high specificity of cell-ELISA for detection of antibodies to alpha-linked galactose.	alpha-linked galactose	285-307	galactosidase beta 1	Homo sapiens	106-124
8766014-4	1996	Secondly, in contrast to uninfected cells and cells infected with beta-galactosidase, the membrane conductance to chloride of CFTR-injected cells was stimulated by cytosolic adenosine 3",5"-cyclic monophosphate (cAMP), which was raised by exposing the cells to 10 microM forskolin.	Chlorides	114-122	galactosidase beta 1	Homo sapiens	66-84
8766014-4	1996	Secondly, in contrast to uninfected cells and cells infected with beta-galactosidase, the membrane conductance to chloride of CFTR-injected cells was stimulated by cytosolic adenosine 3",5"-cyclic monophosphate (cAMP), which was raised by exposing the cells to 10 microM forskolin.	Cyclic AMP	174-210	galactosidase beta 1	Homo sapiens	66-84
8798260-1	1996	Local delivery of Escherichia coli beta-galactosidase gene (beta-gal) to surfactant protein-A (SP-A)-producing cells by a replication-defective recombinant adenovirus (AdCMV.beta-gal) was tested in human 8-12-wk-old fetal lung explants cultured in Waymouth"s medium.	waymouth"s medium	248-265	galactosidase beta 1	Homo sapiens	60-68
8670798-2	1996	In the presence of hsp70 (hsc70), hdj-1 and either ATP or ADP, denatured beta-galactosidase refolds and forms enzymatically active tetramers.	Adenosine Triphosphate	51-54	galactosidase beta 1	Homo sapiens	73-91
8670798-2	1996	In the presence of hsp70 (hsc70), hdj-1 and either ATP or ADP, denatured beta-galactosidase refolds and forms enzymatically active tetramers.	Adenosine Diphosphate	58-61	galactosidase beta 1	Homo sapiens	73-91
8827454-3	1996	The amount of bound avidin-beta-galactosidase was determined using a fluorogenic substrate, 4-methylumbelliferyl-beta-D-galactoside.	4-methylumbelliferyl-galactopyranoside	92-131	galactosidase beta 1	Homo sapiens	27-45
8665521-1	1996	Serum vitamin D3-binding protein (Gc protein) can be converted by beta-galactosidase of B cells and sialidase of T cells to a potent macrophage activating factor, a protein with N-acetylgalactosamine as the remaining sugar moiety.	Acetylgalactosamine	178-199	galactosidase beta 1	Homo sapiens	66-84
8665521-1	1996	Serum vitamin D3-binding protein (Gc protein) can be converted by beta-galactosidase of B cells and sialidase of T cells to a potent macrophage activating factor, a protein with N-acetylgalactosamine as the remaining sugar moiety.	Sugars	217-222	galactosidase beta 1	Homo sapiens	66-84
8673728-5	1996	Results showed that calcium phosphate transfection was optimal for fetal hepatocytes with respect to beta-galactosidase activity and cell survival.	calcium phosphate	20-37	galactosidase beta 1	Homo sapiens	101-119
8642394-7	1996	When the monkeys were immunosuppressed with FK506, muscle fibers expressing beta-galactosidase (beta-gal) were present 1, 4 and 12 weeks after the transplantation.	Tacrolimus	44-49	galactosidase beta 1	Homo sapiens	76-94
8642394-7	1996	When the monkeys were immunosuppressed with FK506, muscle fibers expressing beta-galactosidase (beta-gal) were present 1, 4 and 12 weeks after the transplantation.	Tacrolimus	44-49	galactosidase beta 1	Homo sapiens	76-84
8625293-4	1996	Introduction of UV-damaged or cisplatinum-damaged cytomegalovirus-driven beta-galactosidase reporter DNA into tumor cells revealed a significant decrease (2-5-fold) in reporter expression in p21 -/- versus +/+ cells.	Cisplatin	30-41	galactosidase beta 1	Homo sapiens	73-91
8743443-5	1996	The beta-galactosidase activity of the YES system was significantly increased after treatment with 17 beta-estradiol or the xenoestrogens diethylstilbestrol (DES), o,p"-DDT, and OP but not with vehicle, antiestrogen ICI 164,384, dexamethasone, or testosterone.	Estradiol	99-116	galactosidase beta 1	Homo sapiens	4-22
8743443-5	1996	The beta-galactosidase activity of the YES system was significantly increased after treatment with 17 beta-estradiol or the xenoestrogens diethylstilbestrol (DES), o,p"-DDT, and OP but not with vehicle, antiestrogen ICI 164,384, dexamethasone, or testosterone.	Diethylstilbestrol	138-156	galactosidase beta 1	Homo sapiens	4-22
8743443-5	1996	The beta-galactosidase activity of the YES system was significantly increased after treatment with 17 beta-estradiol or the xenoestrogens diethylstilbestrol (DES), o,p"-DDT, and OP but not with vehicle, antiestrogen ICI 164,384, dexamethasone, or testosterone.	Diethylstilbestrol	158-161	galactosidase beta 1	Homo sapiens	4-22
8743443-5	1996	The beta-galactosidase activity of the YES system was significantly increased after treatment with 17 beta-estradiol or the xenoestrogens diethylstilbestrol (DES), o,p"-DDT, and OP but not with vehicle, antiestrogen ICI 164,384, dexamethasone, or testosterone.	o,p'-DDT	164-172	galactosidase beta 1	Homo sapiens	4-22
8743443-5	1996	The beta-galactosidase activity of the YES system was significantly increased after treatment with 17 beta-estradiol or the xenoestrogens diethylstilbestrol (DES), o,p"-DDT, and OP but not with vehicle, antiestrogen ICI 164,384, dexamethasone, or testosterone.	ici	216-219	galactosidase beta 1	Homo sapiens	4-22
8743443-5	1996	The beta-galactosidase activity of the YES system was significantly increased after treatment with 17 beta-estradiol or the xenoestrogens diethylstilbestrol (DES), o,p"-DDT, and OP but not with vehicle, antiestrogen ICI 164,384, dexamethasone, or testosterone.	Dexamethasone	229-242	galactosidase beta 1	Homo sapiens	4-22
8743443-5	1996	The beta-galactosidase activity of the YES system was significantly increased after treatment with 17 beta-estradiol or the xenoestrogens diethylstilbestrol (DES), o,p"-DDT, and OP but not with vehicle, antiestrogen ICI 164,384, dexamethasone, or testosterone.	Testosterone	247-259	galactosidase beta 1	Homo sapiens	4-22
8743443-7	1996	Albumin and SHBG decreased beta-galactosidase activity in the presence of estradiol to a greater extent than DES, o,p"-DDT, and OP.	Estradiol	74-83	galactosidase beta 1	Homo sapiens	27-45
8743443-8	1996	Human and alligator charcoal-stripped serum were also effective at selectively reducing beta-galactosidase activity in the presence of estradiol compared to xenoestrogens.	Estradiol	135-144	galactosidase beta 1	Homo sapiens	88-106
8849646-4	1996	Intake of the TOS diet induced a decrease in blood cholesterol and a strong increase in beta-galactosidase activity in the hindgut.	tos	14-17	galactosidase beta 1	Homo sapiens	88-106
8743563-4	1996	Binding of 125I-anti-band 3 IgG to band 3-Sepharose gel was partially inhibited by band 3 oligosaccharides or lactoferrin, but was less inhibited by them after they had been treated with N-glycosidase F or endo-beta-galactosidase.	Sepharose	42-51	galactosidase beta 1	Homo sapiens	211-229
8743563-5	1996	A significant part of 125I-anti-band 3 IgG that bound to the band 3-Sepharose gel was released upon treatment of the gel with N-glycosidase F or endo-beta-galactosidase.	Sepharose	68-77	galactosidase beta 1	Homo sapiens	150-168
8629998-2	1996	We report that MIII (but not OLT) is a nontoxic inhibitor of long terminal repeat (LTR)-driven expression of beta-galactosidase in phorbol-12-myristate-13-acetate (PMA)-stimulated and unstimulated 293.27.2 cells (ED50 = 14 +/- 1 and 41 +/- 4 microM, respectively).	Tetradecanoylphorbol Acetate	131-162	galactosidase beta 1	Homo sapiens	109-127
8629998-2	1996	We report that MIII (but not OLT) is a nontoxic inhibitor of long terminal repeat (LTR)-driven expression of beta-galactosidase in phorbol-12-myristate-13-acetate (PMA)-stimulated and unstimulated 293.27.2 cells (ED50 = 14 +/- 1 and 41 +/- 4 microM, respectively).	Tetradecanoylphorbol Acetate	164-167	galactosidase beta 1	Homo sapiens	109-127
8631809-5	1996	In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.	Tetradecanoylphorbol Acetate	139-170	galactosidase beta 1	Homo sapiens	73-91
8934791-2	1996	The procedure is characterized by the use of a micro-organism hypersensitive to beta-lactam antibiotics that contains an inducible cytosolic beta-galactosidase; this enzyme is released when the micro-organism cell wall is disrupted by the antibiotic action, and then measured by the use of a chromogenic substrate.	beta-Lactams	80-91	galactosidase beta 1	Homo sapiens	141-159
8631809-5	1996	In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.	Tetradecanoylphorbol Acetate	172-175	galactosidase beta 1	Homo sapiens	73-91
8631809-5	1996	In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.	Cyclosporine	238-241	galactosidase beta 1	Homo sapiens	73-91
8635490-6	1996	However, cells transfected with the wild-type (Rb-binding) large T segment fusion grew slowly, with surviving clones assuming a predominantly tetraploid karyotype and relatively much lower levels of beta-galactosidase activity upon Zn+2 induction.	Zinc	232-236	galactosidase beta 1	Homo sapiens	199-217
8640824-2	1996	Following infection of breast cancer cells with an adenovirus expressing beta-galactosidase gene, high levels of beta-galactoside activity were observed.	beta-galactoside	113-129	galactosidase beta 1	Homo sapiens	73-91
15048403-2	1996	A competitive immunoassay for 2,4-dichlorophenoxyacetic acid has been developed by combining this amplification cycle with beta-galactosidase as enzyme label resulting in p-aminophenol as product.	2,4-Dichlorophenoxyacetic Acid	30-60	galactosidase beta 1	Homo sapiens	123-141
15048403-2	1996	A competitive immunoassay for 2,4-dichlorophenoxyacetic acid has been developed by combining this amplification cycle with beta-galactosidase as enzyme label resulting in p-aminophenol as product.	4-aminophenol	171-184	galactosidase beta 1	Homo sapiens	123-141
8857193-8	1996	The optimum conditions for inducer concentration and induction time were determined, and the highest production of beta-galactosidase occurred when Dex was added after the cell concentration had reached its maximum in batch culture.	Dexamethasone	148-151	galactosidase beta 1	Homo sapiens	115-133
8850300-10	1996	When poly-N-acetyllactosaminyl saccharide chains of 125I-LF were cleaved by endo beta-galactosidase, the binding of 125I-LF was partially reduced.	poly-n-acetyllactosaminyl saccharide	5-41	galactosidase beta 1	Homo sapiens	81-99
8835215-2	1996	The delivery of the beta-galactosidase (beta-Gal) gene (pCMVlacZ) by lipofectin plus transferrin can achieve 98-100% transfection of HeLa cells as compared to 3-4% by lipofectin alone.	1,2-dielaidoylphosphatidylethanolamine	69-79	galactosidase beta 1	Homo sapiens	20-38
8835215-2	1996	The delivery of the beta-galactosidase (beta-Gal) gene (pCMVlacZ) by lipofectin plus transferrin can achieve 98-100% transfection of HeLa cells as compared to 3-4% by lipofectin alone.	1,2-dielaidoylphosphatidylethanolamine	69-79	galactosidase beta 1	Homo sapiens	40-48
8835215-2	1996	The delivery of the beta-galactosidase (beta-Gal) gene (pCMVlacZ) by lipofectin plus transferrin can achieve 98-100% transfection of HeLa cells as compared to 3-4% by lipofectin alone.	1,2-dielaidoylphosphatidylethanolamine	167-177	galactosidase beta 1	Homo sapiens	20-38
8835215-2	1996	The delivery of the beta-galactosidase (beta-Gal) gene (pCMVlacZ) by lipofectin plus transferrin can achieve 98-100% transfection of HeLa cells as compared to 3-4% by lipofectin alone.	1,2-dielaidoylphosphatidylethanolamine	167-177	galactosidase beta 1	Homo sapiens	40-48
8850303-6	1996	The inhibitory activity of band 3 oligosaccharides and lactoferrin oligosaccharides was little affected by treatment with endo-beta-galactosidase, which specifically cleaves poly-N-acetyllactosamine to shorter oligosaccharides.	poly-N-acetyllactosamine	174-198	galactosidase beta 1	Homo sapiens	127-145
8929821-1	1996	OBJECTIVE: To develop methods based on enzyme activation for the analysis of sweat sodium and chloride using beta-galactosidase and alpha-amylase, respectively.	Sodium	83-89	galactosidase beta 1	Homo sapiens	109-127
8835131-5	1996	The insert sequence was determined and the beta-galactosidase fusion protein was partially purified by electroelution from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) gels.	Sodium Dodecyl Sulfate	123-145	galactosidase beta 1	Homo sapiens	43-61
8835131-5	1996	The insert sequence was determined and the beta-galactosidase fusion protein was partially purified by electroelution from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) gels.	polyacrylamide	146-160	galactosidase beta 1	Homo sapiens	43-61
8929821-1	1996	OBJECTIVE: To develop methods based on enzyme activation for the analysis of sweat sodium and chloride using beta-galactosidase and alpha-amylase, respectively.	Chlorides	94-102	galactosidase beta 1	Homo sapiens	109-127
8835131-5	1996	The insert sequence was determined and the beta-galactosidase fusion protein was partially purified by electroelution from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) gels.	Sodium Dodecyl Sulfate	182-185	galactosidase beta 1	Homo sapiens	43-61
7585518-8	1995	ET-18-OCH3 markedly inhibits TPA-induced NF-kappa B activation, as measured by HIV long terminal repeat-directed expression of beta-galactosidase.	edelfosine	0-10	galactosidase beta 1	Homo sapiens	127-145
8720464-10	1996	Staining with monoclonal antibodies or lectins combined with endo-beta-galactosidase digestion procedures have been proven to be powerful tools for localizing and analyzing different types of poly-N-acetyllactosamine structures in normal and malignant tissues.	poly-N-acetyllactosamine	192-216	galactosidase beta 1	Homo sapiens	66-84
8573395-1	1995	A serum glycoprotein, vitamin D3-binding protein (Gc protein), can be converted by beta-galactosidase of stimulated B lymphocytes and sialidase of T lymphocytes to a potent macrophage-activating factor (MAF), a protein with N-acetylgalactosamine as the remaining sugar moiety.	Sugars	263-268	galactosidase beta 1	Homo sapiens	83-101
8720464-2	1996	Monoclonal antibodies, lectins and endo-beta-galactosidase are useful histochemical tools for detecting and analyzing poly-N-acetyllactosamines in tissue sections.	poly-N-acetyllactosamine	118-143	galactosidase beta 1	Homo sapiens	40-58
8526908-1	1995	Addition of short-chain phospholipids to the gramicidin S-DNA-dioleoyl phosphatidylethanolamine complex enhanced up to 6-fold beta-galactosidase expression in several cell-lines in vitro.	Phospholipids	24-37	galactosidase beta 1	Homo sapiens	126-144
8526908-1	1995	Addition of short-chain phospholipids to the gramicidin S-DNA-dioleoyl phosphatidylethanolamine complex enhanced up to 6-fold beta-galactosidase expression in several cell-lines in vitro.	gramicidin s-dna-dioleoyl phosphatidylethanolamine	45-95	galactosidase beta 1	Homo sapiens	126-144
8573395-1	1995	A serum glycoprotein, vitamin D3-binding protein (Gc protein), can be converted by beta-galactosidase of stimulated B lymphocytes and sialidase of T lymphocytes to a potent macrophage-activating factor (MAF), a protein with N-acetylgalactosamine as the remaining sugar moiety.	Acetylgalactosamine	224-245	galactosidase beta 1	Homo sapiens	83-101
7585518-8	1995	ET-18-OCH3 markedly inhibits TPA-induced NF-kappa B activation, as measured by HIV long terminal repeat-directed expression of beta-galactosidase.	Tetradecanoylphorbol Acetate	29-32	galactosidase beta 1	Homo sapiens	127-145
7543732-6	1995	Although apigenin did not inhibit TNF-alpha-induced nuclear translocation of NF-kappa B(p50(NFKB1)/p65(RelA)) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements, suggesting an action on NF-kappa B transcriptional activation.	Flavonoids	124-133	galactosidase beta 1	Homo sapiens	164-182
8548549-5	1995	beta-Gal expression was significantly enhanced by formulation of the DNA-DC-Chol/DOPE complexes in physiological solution at pH 9.0.	chol	76-80	galactosidase beta 1	Homo sapiens	0-8
8548549-5	1995	beta-Gal expression was significantly enhanced by formulation of the DNA-DC-Chol/DOPE complexes in physiological solution at pH 9.0.	1,2-dielaidoylphosphatidylethanolamine	81-85	galactosidase beta 1	Homo sapiens	0-8
8551257-9	1995	It takes advantage of the high affinity of biotin for the multivalent binding sites of streptavidin-labelled beta-galactosidase, and combines the amplification effect of biotin-streptavidin interaction with the high sensitivity of fluorogenic detection methods.	Biotin	43-49	galactosidase beta 1	Homo sapiens	109-127
8551257-9	1995	It takes advantage of the high affinity of biotin for the multivalent binding sites of streptavidin-labelled beta-galactosidase, and combines the amplification effect of biotin-streptavidin interaction with the high sensitivity of fluorogenic detection methods.	Biotin	170-176	galactosidase beta 1	Homo sapiens	109-127
7543732-6	1995	Although apigenin did not inhibit TNF-alpha-induced nuclear translocation of NF-kappa B(p50(NFKB1)/p65(RelA)) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements, suggesting an action on NF-kappa B transcriptional activation.	Flavonoids	124-133	galactosidase beta 1	Homo sapiens	233-251
8550383-1	1995	Blood-group-related antigens expressed in papillary carcinomas and other types of neoplasm of the human thyroid glands have been shown to be carried by poly-N-acetyllactosamines containing a linear domain susceptible to endo-beta-galactosidase digestion.	poly-N-acetyllactosamine	152-177	galactosidase beta 1	Homo sapiens	225-243
7669666-9	1995	Analysis of another fluorescence assay using fluorescein di-beta galactopyranoside as a substrate for beta-galactosidase in cells transduced with a MDR1: beta-gal activity.	fluorescein di-beta galactopyranoside	45-82	galactosidase beta 1	Homo sapiens	102-120
7635184-4	1995	beta-galactosidase activity, encoded by a reporter lac z construct and controlled by a transcription factor in thalidomide-treated PMA- and ionomycin-stimulated Jurkat cells, was similar (97 +/- 1.33%; p &gt; 0.1) to non-thalidomide-treated controls at all drug concentrations tested.	Thalidomide	111-122	galactosidase beta 1	Homo sapiens	0-18
7635184-4	1995	beta-galactosidase activity, encoded by a reporter lac z construct and controlled by a transcription factor in thalidomide-treated PMA- and ionomycin-stimulated Jurkat cells, was similar (97 +/- 1.33%; p &gt; 0.1) to non-thalidomide-treated controls at all drug concentrations tested.	Ionomycin	140-149	galactosidase beta 1	Homo sapiens	0-18
8846006-7	1995	The FORSE-1 epitope is sensitive to endo-beta-galactosidase, suggesting that the epitope corresponds to a carbohydrate moiety.	Carbohydrates	106-118	galactosidase beta 1	Homo sapiens	41-59
7784080-0	1995	Expression of beta-galactosidase under the control of the human c-myc promoter in transgenic mice is inhibited by mithramycin.	Plicamycin	114-125	galactosidase beta 1	Homo sapiens	14-32
7629796-2	1995	A small number of quinazolinedione analogs were identified from random screening to possess low micromolar (1.3-4.4 microM) potency in the nuclear factor of activated T cells-1-regulated beta-galactosidase expression assay.	Quinazolinones	18-34	galactosidase beta 1	Homo sapiens	187-205
7629796-6	1995	Binding affinity data for displacement of radiolabeled 4s from Jurkat cell membranes reflected an excellent correlation with the IC50 value for inhibition of beta-galactosidase activity.	4s	55-57	galactosidase beta 1	Homo sapiens	158-176
7608901-8	1995	In the case of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP, 7), which is a potent beta-galactosidase inhibitor, its N-methyl (8) and N-butyl (9) derivatives completely lost potency toward beta-galactosidase as well.	2,5-dideoxy-2,5-imino-D-mannitol	15-47	galactosidase beta 1	Homo sapiens	77-95
7608901-8	1995	In the case of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP, 7), which is a potent beta-galactosidase inhibitor, its N-methyl (8) and N-butyl (9) derivatives completely lost potency toward beta-galactosidase as well.	2,5-dideoxy-2,5-imino-D-mannitol	15-47	galactosidase beta 1	Homo sapiens	183-201
7608901-8	1995	In the case of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP, 7), which is a potent beta-galactosidase inhibitor, its N-methyl (8) and N-butyl (9) derivatives completely lost potency toward beta-galactosidase as well.	2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	49-53	galactosidase beta 1	Homo sapiens	77-95
7608901-8	1995	In the case of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP, 7), which is a potent beta-galactosidase inhibitor, its N-methyl (8) and N-butyl (9) derivatives completely lost potency toward beta-galactosidase as well.	2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	49-53	galactosidase beta 1	Homo sapiens	183-201
7784080-2	1995	Transgenic mouse embryos heterozygous for the human c-myc Z transgene demonstrate high amounts of beta-galactosidase activity as early as day 11 of embryogenesis by histochemical staining of whole embryos using 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-Gal) as substrate, localizing specifically to early spinal cord tissue.	5-bromo-4-chloro-3-indolyl beta-galactoside	211-262	galactosidase beta 1	Homo sapiens	98-116
7784080-2	1995	Transgenic mouse embryos heterozygous for the human c-myc Z transgene demonstrate high amounts of beta-galactosidase activity as early as day 11 of embryogenesis by histochemical staining of whole embryos using 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-Gal) as substrate, localizing specifically to early spinal cord tissue.	5-bromo-4-chloro-3-indolyl beta-galactoside	264-269	galactosidase beta 1	Homo sapiens	98-116
7784080-8	1995	These results are unique since we are able to detect expression of beta-galactosidase in developing embryonic central nervous system tissue along with adult brain tissue of animals carrying the human c-myc Z transgene and we are able to specifically inhibit expression of the transgene using mithramycin administered in utero.	Plicamycin	292-303	galactosidase beta 1	Homo sapiens	67-85
7619207-7	1995	A reporter gene assay that monitored the coupling of CTR to adenylate cyclase by increases in beta-galactosidase activity indicated that both receptors were able to stimulate cyclic AMP production in response to ligand binding.	Cyclic AMP	175-185	galactosidase beta 1	Homo sapiens	94-112
7554557-2	1995	METHODS: Normal IgG1 and IgG3 were affinity-purified, and sialic acid and galactose were clipped off using neuraminidase and beta-galactosidase, respectively.	N-Acetylneuraminic Acid	58-69	galactosidase beta 1	Homo sapiens	125-143
18623263-6	1995	Nearly 100% of the beta-galactosidase, which carries a net negative charge, partitioned to the DEAE-dextran-rich phase regardless of whether the phase was dextran or PEG.	DEAE-Dextran	95-107	galactosidase beta 1	Homo sapiens	19-37
18623263-6	1995	Nearly 100% of the beta-galactosidase, which carries a net negative charge, partitioned to the DEAE-dextran-rich phase regardless of whether the phase was dextran or PEG.	Dextrans	100-107	galactosidase beta 1	Homo sapiens	19-37
18623263-12	1995	Little effect on partitioning was observed when the protein and polymer had the same charge, with the exception of beta-galactosidase with polyarginine tails.	polyarginine	139-151	galactosidase beta 1	Homo sapiens	115-133
7532004-5	1995	The proportions of each monosaccharide and the sensitivity to endo-beta-galactosidase indicated that CHIP28 contained polylactosaminyl oligosaccharides.	polylactosaminyl oligosaccharides	118-151	galactosidase beta 1	Homo sapiens	67-85
7785765-1	1995	beta-Galactosidase can be assayed by monitoring the generation of the fluorescent products, fluorescein-mono-beta-D-galactopyranoside and fluorescein, when the fluorogenic substrate fluorescein-di-beta-D-galactopyranoside is used.	fluorescein monogalactoside	92-133	galactosidase beta 1	Homo sapiens	0-18
7785765-1	1995	beta-Galactosidase can be assayed by monitoring the generation of the fluorescent products, fluorescein-mono-beta-D-galactopyranoside and fluorescein, when the fluorogenic substrate fluorescein-di-beta-D-galactopyranoside is used.	Fluorescein	92-103	galactosidase beta 1	Homo sapiens	0-18
7785765-1	1995	beta-Galactosidase can be assayed by monitoring the generation of the fluorescent products, fluorescein-mono-beta-D-galactopyranoside and fluorescein, when the fluorogenic substrate fluorescein-di-beta-D-galactopyranoside is used.	fluorescein-digalactoside	182-221	galactosidase beta 1	Homo sapiens	0-18
7785765-3	1995	By analyzing as little as 40 pl of the enzymatic mixture we obtain limits of detection of 6.5 x 10(-14) M beta-galactosidase or 1.6 molecules based on the detection of fluorescein-mono-beta-D-galactopyranoside.	fluorescein monogalactoside	168-209	galactosidase beta 1	Homo sapiens	106-124
7737204-4	1995	When necessary, oligosaccharides were treated with endo-beta-galactosidase (and N-acetyl-beta-glucosaminidase) followed by 1H-NMR analysis of the incubation products, to obtain additional structural information.	Oligosaccharides	16-32	galactosidase beta 1	Homo sapiens	56-74
7737204-9	1995	Tetraantennary oligosaccharides with N-acetyllactosamine repeats could be digested quantitatively with endo-beta-galactosidase from Bacteroides fragilis, whereas under the same conditions tri" antennary oligosaccharides hardly reacted (&lt; 15%).	Oligosaccharides	15-31	galactosidase beta 1	Homo sapiens	108-126
7737204-9	1995	Tetraantennary oligosaccharides with N-acetyllactosamine repeats could be digested quantitatively with endo-beta-galactosidase from Bacteroides fragilis, whereas under the same conditions tri" antennary oligosaccharides hardly reacted (&lt; 15%).	N-acetyllactosamine	37-56	galactosidase beta 1	Homo sapiens	108-126
7719929-6	1995	In contrast, co-infection with AdIL8.beta gal and AdEGR1.TNF demonstrated, for a given dose of AdIL8.beta gal, increasing amounts of beta-gal expression dependent on the dose of AdEGR1.TNF.	adil8	31-36	galactosidase beta 1	Homo sapiens	133-141
7597380-8	1995	Studies by Western blot confirmed the presence of terminal N-acetylglucosamine on heavy chains, and percentages of Gal(0) comparable to those seen in human RA could be generated by exposing goat IgG to streptococcal beta-galactosidase.	Acetylglucosamine	59-78	galactosidase beta 1	Homo sapiens	216-234
8597627-4	1995	After digestion with beta-galactosidase there was an increase in terminal GlcNAc indicating an increase in % agalactosyl IgG to approximately 30%.	2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose	74-80	galactosidase beta 1	Homo sapiens	21-39
7699133-0	1994	Factors affecting the ability of a high beta-galactosidase yogurt to enhance lactose absorption.	Lactose	77-84	galactosidase beta 1	Homo sapiens	40-58
7699133-1	1994	Lactose in yogurt is better absorbed by lactase-deficient subjects than is an equivalent quantity of lactose in milk, presumably because of the microbial activity of the beta-galactosidase present in yogurt.	Lactose	0-7	galactosidase beta 1	Homo sapiens	170-188
7695107-3	1994	The reaction was terminated by adding EDTA and the level of incorporated biotin was measured with streptavidin-beta-galactosidase.	Biotin	73-79	galactosidase beta 1	Homo sapiens	111-129
7989605-5	1994	Ether extracts of 0.8 ml of serum were incubated with yeast for 8 h and the beta-galactosidase response was used to determine estrogen bioactivity relative to estradiol standards prepared in charcoal-stripped plasma.	Ether	0-5	galactosidase beta 1	Homo sapiens	76-94
7991129-2	1994	He was a homozygote for the 51isoleucine (ATC)--&gt;threonine (ACC) mutation in the beta-galactosidase gene.	Threonine	52-61	galactosidase beta 1	Homo sapiens	84-102
7999119-4	1994	As compared to the control (= 1.0), the beta-galactosidase activities expressed in CFT1 cells transfected with lectin-PL/His-DNA containing 5 micrograms/ml conjugate and 10 micrograms/ml DNA were: Con A-His, 7.7; SNA-His, 3.5; Con A-PL, 2.4; WGA-PL/His, 1.3; others, 1.0.	sna-his	213-220	galactosidase beta 1	Homo sapiens	40-58
7999119-4	1994	As compared to the control (= 1.0), the beta-galactosidase activities expressed in CFT1 cells transfected with lectin-PL/His-DNA containing 5 micrograms/ml conjugate and 10 micrograms/ml DNA were: Con A-His, 7.7; SNA-His, 3.5; Con A-PL, 2.4; WGA-PL/His, 1.3; others, 1.0.	con a-pl	227-235	galactosidase beta 1	Homo sapiens	40-58
7999119-4	1994	As compared to the control (= 1.0), the beta-galactosidase activities expressed in CFT1 cells transfected with lectin-PL/His-DNA containing 5 micrograms/ml conjugate and 10 micrograms/ml DNA were: Con A-His, 7.7; SNA-His, 3.5; Con A-PL, 2.4; WGA-PL/His, 1.3; others, 1.0.	Polylysine	118-120	galactosidase beta 1	Homo sapiens	40-58
7998946-5	1994	The precursor is readily taken up in a mannose-6-phosphate-dependent manner into beta-galactosidase-deficient, GM1-gangliosidosis fibroblasts, and the enzyme activity is returned to normal levels.	mannose-6-phosphate	39-58	galactosidase beta 1	Homo sapiens	81-99
7881170-7	1994	Treatment of total first-trimester cytotrophoblast beta 1 integrins or the isolated alpha 5/beta 1 fibronectin receptor with endo-beta-galactosidase restored electrophoretic mobility to control levels, suggesting the presence of polylactosamine-bearing oligosaccharides.	polylactosamine	229-244	galactosidase beta 1	Homo sapiens	130-148
7881170-7	1994	Treatment of total first-trimester cytotrophoblast beta 1 integrins or the isolated alpha 5/beta 1 fibronectin receptor with endo-beta-galactosidase restored electrophoretic mobility to control levels, suggesting the presence of polylactosamine-bearing oligosaccharides.	Oligosaccharides	253-269	galactosidase beta 1	Homo sapiens	130-148
7765485-1	1994	An E. coli expression clone coding for human proinsulin, which was fused to NH2-terminal beta-galactosidase, was engineered for the separation from host proteins by introducing peptide devices, and for the sequential removal of the fused polypeptide by cyanogen bromide in front of the NH2 terminal residue (methionine) of the human proinsulin gene.	Cyanogen Bromide	253-269	galactosidase beta 1	Homo sapiens	89-107
7521878-9	1994	Endo-beta-galactosidase-treated PSGL-1 retained the ability to bind to P-selectin, suggesting that some of the oligosaccharides recognized by P-selectin were either on enzyme-resistant poly-N-acetyllactosamine or on chains which lack poly-N-acetyllactosamine.	Oligosaccharides	111-127	galactosidase beta 1	Homo sapiens	5-23
7521878-9	1994	Endo-beta-galactosidase-treated PSGL-1 retained the ability to bind to P-selectin, suggesting that some of the oligosaccharides recognized by P-selectin were either on enzyme-resistant poly-N-acetyllactosamine or on chains which lack poly-N-acetyllactosamine.	poly-N-acetyllactosamine	185-209	galactosidase beta 1	Homo sapiens	5-23
7521878-9	1994	Endo-beta-galactosidase-treated PSGL-1 retained the ability to bind to P-selectin, suggesting that some of the oligosaccharides recognized by P-selectin were either on enzyme-resistant poly-N-acetyllactosamine or on chains which lack poly-N-acetyllactosamine.	poly-N-acetyllactosamine	234-258	galactosidase beta 1	Homo sapiens	5-23
18618835-0	1994	Ion exchange immobilization of changed beta-galactosidase fusions for lactose hydrolysis.	Lactose	70-77	galactosidase beta 1	Homo sapiens	39-57
7765485-1	1994	An E. coli expression clone coding for human proinsulin, which was fused to NH2-terminal beta-galactosidase, was engineered for the separation from host proteins by introducing peptide devices, and for the sequential removal of the fused polypeptide by cyanogen bromide in front of the NH2 terminal residue (methionine) of the human proinsulin gene.	Methionine	308-318	galactosidase beta 1	Homo sapiens	89-107
7765485-4	1994	The chelating peptide covering the NH2-terminal beta-galactosidase portion could then be removed simply after purification to generate a protein with the natural amino acid sequence of proinsulin by cyanogen bromide.	Cyanogen Bromide	199-215	galactosidase beta 1	Homo sapiens	48-66
7836658-2	1994	For this method, the reaction mixture contained a fluorescent substrate, 4-methylumbelliferyl-beta-D-xyloside as an acceptor, UDP-galactose as a donor and D-galactal as a competitive inhibitor of endogenous beta-galactosidase in the enzyme solution.	galactal	155-165	galactosidase beta 1	Homo sapiens	207-225
7989868-3	1994	Im-DCH-beta-Gal was shown to be a specific substrate for human lysosomal beta-galactosidase in cell homogenates.	O-(4-(1-imidazolyl)butyl)-2,3-dicyano-1,4-hydroquinonylgalactopyranoside	0-15	galactosidase beta 1	Homo sapiens	73-91
7827404-3	1994	We used poly(L-lysine) conjugates of the monoclonal antibody 1E3 directed against the Tn antigen to deliver the luciferase and beta-galactosidase reporter genes to Jurkat cells by receptor-mediated endocytosis.	poly(l-lysine)	8-22	galactosidase beta 1	Homo sapiens	127-145
7827404-7	1994	When the beta-galactosidase (lacZ) gene was delivered to Jurkat cells by Tn-mediated endocytosis, up to 60% of the cells were positive in the cytochemical stain using 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-gal) as a chromogenic substrate.	5-bromo-4-chloro-3-indolyl beta-galactoside	167-218	galactosidase beta 1	Homo sapiens	9-27
7827404-7	1994	When the beta-galactosidase (lacZ) gene was delivered to Jurkat cells by Tn-mediated endocytosis, up to 60% of the cells were positive in the cytochemical stain using 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (X-gal) as a chromogenic substrate.	5-bromo-4-chloro-3-indolyl beta-galactoside	220-225	galactosidase beta 1	Homo sapiens	9-27
8061002-6	1994	The location of the fucose residues in the monofucosylated and difucosylated intermediate products was determined by analyzing digests obtained after endo-beta-galactosidase treatment using HPLC on amino-bonded silica.	Fucose	20-26	galactosidase beta 1	Homo sapiens	155-173
7989868-5	1994	Very little hydrolysis of Im-DCH-beta-Gal(OAc)4 was observed in fibroblasts genetically deficient in lysosomal acid beta-galactosidase or in normal cells pretreated with the lysosomal inhibitors chloroquine and ammonium chloride.	im-dch-beta-gal(oac)4	26-47	galactosidase beta 1	Homo sapiens	116-134
8039189-1	1994	N-Acetyl-lactosamine(beta-D-Gal p-(1--&gt;4)-D-Glc pNAc) was synthesized regioselectively with the aid of the transglycosylation activity of beta-galactosidase isolated from Diplococcus pneumoniae using p-nitrophenyl beta-D-galactopyranoside as the donor.	N-acetyllactosamine	0-20	galactosidase beta 1	Homo sapiens	141-159
7813394-5	1994	Information on the structure of the glycans was revealed by the changes in the band patterns observed after the mixtures of the glycan fluorophore derivatives were treated with either of the enzymes neuraminidase or beta-galactosidase.	Polysaccharides	36-43	galactosidase beta 1	Homo sapiens	216-234
7813394-5	1994	Information on the structure of the glycans was revealed by the changes in the band patterns observed after the mixtures of the glycan fluorophore derivatives were treated with either of the enzymes neuraminidase or beta-galactosidase.	Polysaccharides	36-42	galactosidase beta 1	Homo sapiens	216-234
7518456-3	1994	The senescent cells whose surface band 3 saccharide chains were cleaved by endo-beta-galactosidase or totally removed by N-glycosidase F showed decreased binding of the anti-human IgG.	Carbohydrates	41-51	galactosidase beta 1	Homo sapiens	80-98
8058842-1	1994	beta-Galactosidase (EC 3.2.1.23) from persimmon fruit was purified 114-fold with a 15% yield using Sephadex G-100 gel filtration, CM-Sephadex ion exchange, and Sephacryl S-200 gel filtration chromatography, with subsequent electroelution from nondenaturing polyacrylamide gel electrophoresis (PAGE) gels.	sephadex	99-113	galactosidase beta 1	Homo sapiens	0-18
8058842-1	1994	beta-Galactosidase (EC 3.2.1.23) from persimmon fruit was purified 114-fold with a 15% yield using Sephadex G-100 gel filtration, CM-Sephadex ion exchange, and Sephacryl S-200 gel filtration chromatography, with subsequent electroelution from nondenaturing polyacrylamide gel electrophoresis (PAGE) gels.	sephadex	99-107	galactosidase beta 1	Homo sapiens	0-18
8058842-1	1994	beta-Galactosidase (EC 3.2.1.23) from persimmon fruit was purified 114-fold with a 15% yield using Sephadex G-100 gel filtration, CM-Sephadex ion exchange, and Sephacryl S-200 gel filtration chromatography, with subsequent electroelution from nondenaturing polyacrylamide gel electrophoresis (PAGE) gels.	sephacryl S 200	160-175	galactosidase beta 1	Homo sapiens	0-18
8058842-1	1994	beta-Galactosidase (EC 3.2.1.23) from persimmon fruit was purified 114-fold with a 15% yield using Sephadex G-100 gel filtration, CM-Sephadex ion exchange, and Sephacryl S-200 gel filtration chromatography, with subsequent electroelution from nondenaturing polyacrylamide gel electrophoresis (PAGE) gels.	polyacrylamide	257-271	galactosidase beta 1	Homo sapiens	0-18
8058842-2	1994	The estimated molecular mass of the native beta-galactosidase by Sephacryl S-200 was 118 kD.	sephacryl S 200	65-80	galactosidase beta 1	Homo sapiens	43-61
8039189-1	1994	N-Acetyl-lactosamine(beta-D-Gal p-(1--&gt;4)-D-Glc pNAc) was synthesized regioselectively with the aid of the transglycosylation activity of beta-galactosidase isolated from Diplococcus pneumoniae using p-nitrophenyl beta-D-galactopyranoside as the donor.	beta-d-gal p-	21-34	galactosidase beta 1	Homo sapiens	141-159
8039189-1	1994	N-Acetyl-lactosamine(beta-D-Gal p-(1--&gt;4)-D-Glc pNAc) was synthesized regioselectively with the aid of the transglycosylation activity of beta-galactosidase isolated from Diplococcus pneumoniae using p-nitrophenyl beta-D-galactopyranoside as the donor.	1--&gt;4)-d-glc pnac	35-55	galactosidase beta 1	Homo sapiens	141-159
8039189-1	1994	N-Acetyl-lactosamine(beta-D-Gal p-(1--&gt;4)-D-Glc pNAc) was synthesized regioselectively with the aid of the transglycosylation activity of beta-galactosidase isolated from Diplococcus pneumoniae using p-nitrophenyl beta-D-galactopyranoside as the donor.	4-nitrophenylgalactoside	203-241	galactosidase beta 1	Homo sapiens	141-159
7987700-3	1994	We observed that NF (+) and GABA (+) neuronal as well as GFA-P (+) glial cells could express beta-galactosidase activity after inoculation.	gamma-Aminobutyric Acid	28-32	galactosidase beta 1	Homo sapiens	93-111
7936206-9	1994	In addition, we show that two cytoplasmic enzymes, beta-galactosidase and chloramphenicol acetyl transferase, are able to diffuse freely in the cytoplasm reaching even growth cones in young neurons, while the chimeric protein tissue inhibitor of metalloproteinases/Thy-1 is correctly targeted to the plasma membrane via a glycosyl-phosphatidylinositol anchor.	Phosphatidylinositols	331-351	galactosidase beta 1	Homo sapiens	51-69
7519451-4	1994	In contrast, beta-gal activity was detected at the same time points in tumor cells from animals receiving intraperitoneal Ad.RSV beta gal.	rsv beta gal	125-137	galactosidase beta 1	Homo sapiens	13-21
8068159-0	1994	Normal serum beta-galactosidase in juvenile GM1 gangliosidosis.	G(M1) Ganglioside	44-47	galactosidase beta 1	Homo sapiens	13-31
8200356-0	1994	Hydrolysis of lactosylceramide by human galactosylceramidase and GM1-beta-galactosidase in a detergent-free system and its stimulation by sphingolipid activator proteins, sap-B and sap-C.	CDw17 antigen	14-30	galactosidase beta 1	Homo sapiens	69-87
8200356-7	1994	Hydrolysis of liposomal lactosylceramide was compared with sap-B-stimulated hydrolysis of liposomal ganglioside GM1 by GM1-beta-galactosidase and sap-C-stimulated degradation of liposomal galactosylceramide by galactosylceramidase.	sap-b	59-64	galactosidase beta 1	Homo sapiens	123-141
8200356-7	1994	Hydrolysis of liposomal lactosylceramide was compared with sap-B-stimulated hydrolysis of liposomal ganglioside GM1 by GM1-beta-galactosidase and sap-C-stimulated degradation of liposomal galactosylceramide by galactosylceramidase.	G(M1) Ganglioside	119-122	galactosidase beta 1	Homo sapiens	123-141
8200356-12	1994	GM1-beta-galactosidase was more active on these complexes than on glycolipids (GM1 and lactosylceramides) still residing in liposomal membranes.	Glycolipids	66-77	galactosidase beta 1	Homo sapiens	4-22
8200356-12	1994	GM1-beta-galactosidase was more active on these complexes than on glycolipids (GM1 and lactosylceramides) still residing in liposomal membranes.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	4-22
8200356-12	1994	GM1-beta-galactosidase was more active on these complexes than on glycolipids (GM1 and lactosylceramides) still residing in liposomal membranes.	Lactosylceramides	87-104	galactosidase beta 1	Homo sapiens	4-22
8168537-9	1994	Analysis of the endo-beta-galactosidase digests of pools of N- and O-glycans indicated that the two types of oligosaccharides contain qualitatively similar poly(N-acetyllactosamine) chains.	n- and o-glycans	60-76	galactosidase beta 1	Homo sapiens	21-39
8168537-9	1994	Analysis of the endo-beta-galactosidase digests of pools of N- and O-glycans indicated that the two types of oligosaccharides contain qualitatively similar poly(N-acetyllactosamine) chains.	Oligosaccharides	109-125	galactosidase beta 1	Homo sapiens	21-39
7519451-5	1994	Flow cytometric quantification of beta-gal activity in recovered cells showed &lt; 3% beta-gal-positive cells in animals administered control virus, but in animals administered intraperitoneal Ad.RSV beta gal there was a mean of 71 +/- 18% positive cells at 3 days and 56 +/- 27% at 14 days.	rsv beta gal	196-208	galactosidase beta 1	Homo sapiens	34-42
8308972-6	1994	Prostate cancer cells from patients with stage T2 prostate cancer undergoing radical prostatectomy were first transduced with MFG-lacZ, a retroviral vector carrying the beta-galactosidase reporter gene.	mfg-lacz	126-134	galactosidase beta 1	Homo sapiens	169-187
8132543-7	1994	When the zinc finger structure was altered by mutating a zinc-chelating cysteine residue in any one of the three zinc fingers, the resulting domain was no longer capable of directing beta-galactosidase to the nucleus.	Cysteine	72-80	galactosidase beta 1	Homo sapiens	183-201
7907018-8	1994	The 70-kDa constitutive heat-shock proteins and the 68-kDa protein kinase are ATP-binding proteins but ATP depletion also considerably increases the aggregation of beta-galactosidase to the nuclear pellets, although this enzyme is not known to be an ATP-binding molecule.	Adenosine Triphosphate	78-81	galactosidase beta 1	Homo sapiens	164-182
8119903-2	1994	Methoxylamine mutagenesis of the beta-galactosidase gene from Lactobacillus delbruckii subsp.	methoxyamine	0-13	galactosidase beta 1	Homo sapiens	33-51
7907018-8	1994	The 70-kDa constitutive heat-shock proteins and the 68-kDa protein kinase are ATP-binding proteins but ATP depletion also considerably increases the aggregation of beta-galactosidase to the nuclear pellets, although this enzyme is not known to be an ATP-binding molecule.	Adenosine Triphosphate	103-106	galactosidase beta 1	Homo sapiens	164-182
7907018-8	1994	The 70-kDa constitutive heat-shock proteins and the 68-kDa protein kinase are ATP-binding proteins but ATP depletion also considerably increases the aggregation of beta-galactosidase to the nuclear pellets, although this enzyme is not known to be an ATP-binding molecule.	Adenosine Triphosphate	103-106	galactosidase beta 1	Homo sapiens	164-182
8238009-5	1993	The median urinary beta-galactosidase activity for the pregnant population, when expressed on the basis of creatinine, was twofold higher than that of the control group (P &lt; 0.0005).	Creatinine	107-117	galactosidase beta 1	Homo sapiens	19-37
7506734-8	1994	Another glycosidase, endo-beta-galactosidase, which specifically cleaves the beta 1-4 galactose linkage to N-acetyl-glucosamine when it exists in an extended chain form such as that found in sialyl-dimeric Le(x), significantly inhibited eosinophil and neutrophil adhesion and expression of sialyl-dimeric Le(x).	Acetylglucosamine	107-127	galactosidase beta 1	Homo sapiens	26-44
7509588-3	1994	In this system, levels of beta-galactosidase activity are proportionally and specifically related to the presence and concentrations of several specific simple selenium derivatives.	Selenium	160-168	galactosidase beta 1	Homo sapiens	26-44
7932108-3	1994	The optimum pH for beta-galactosidase activity was 7.0 and required Ca2+ and glutathione for enhancement of its activity; IPTG also slightly improved the activity.	Glutathione	77-88	galactosidase beta 1	Homo sapiens	19-37
7932108-3	1994	The optimum pH for beta-galactosidase activity was 7.0 and required Ca2+ and glutathione for enhancement of its activity; IPTG also slightly improved the activity.	Isopropyl Thiogalactoside	122-126	galactosidase beta 1	Homo sapiens	19-37
7932108-7	1994	Arabinose, xylose and galactose induced the A. caviae beta-galactosidase activity by several folds and lactose moderately enhanced its activity.	Arabinose	0-9	galactosidase beta 1	Homo sapiens	54-72
7932108-7	1994	Arabinose, xylose and galactose induced the A. caviae beta-galactosidase activity by several folds and lactose moderately enhanced its activity.	Xylose	11-17	galactosidase beta 1	Homo sapiens	54-72
7932108-7	1994	Arabinose, xylose and galactose induced the A. caviae beta-galactosidase activity by several folds and lactose moderately enhanced its activity.	Galactose	22-31	galactosidase beta 1	Homo sapiens	54-72
7932108-7	1994	Arabinose, xylose and galactose induced the A. caviae beta-galactosidase activity by several folds and lactose moderately enhanced its activity.	Lactose	24-31	galactosidase beta 1	Homo sapiens	54-72
8116603-1	1994	Beta-galactosidase (lactase) allows the digestion of lactose as its component sugars, galactose and glucose.	Lactose	53-60	galactosidase beta 1	Homo sapiens	0-18
8116603-1	1994	Beta-galactosidase (lactase) allows the digestion of lactose as its component sugars, galactose and glucose.	Sugars	78-84	galactosidase beta 1	Homo sapiens	0-18
8116603-1	1994	Beta-galactosidase (lactase) allows the digestion of lactose as its component sugars, galactose and glucose.	Galactose	86-95	galactosidase beta 1	Homo sapiens	0-18
8116603-1	1994	Beta-galactosidase (lactase) allows the digestion of lactose as its component sugars, galactose and glucose.	Glucose	100-107	galactosidase beta 1	Homo sapiens	0-18
9480084-9	1994	Endo-beta-galactosidase, splitting type 2 chains from human red cells, abolishes reactivity of both CAs.	Calcium	100-103	galactosidase beta 1	Homo sapiens	5-23
8297011-3	1993	In this study, we compared the pH and salt requirements, as well as the heat stability, of bacterial and eukaryotic beta-galactosidase in order to identify conditions which would inhibit the beta-galactosidase enzyme endogenous to eukaryotic cells without adversely affecting the activity of either purified bacterial beta-galactosidase or reporter beta-galactosidase produced after transfection of expression vectors into eukaryotic cells.	Salts	38-42	galactosidase beta 1	Homo sapiens	191-209
8297011-3	1993	In this study, we compared the pH and salt requirements, as well as the heat stability, of bacterial and eukaryotic beta-galactosidase in order to identify conditions which would inhibit the beta-galactosidase enzyme endogenous to eukaryotic cells without adversely affecting the activity of either purified bacterial beta-galactosidase or reporter beta-galactosidase produced after transfection of expression vectors into eukaryotic cells.	Salts	38-42	galactosidase beta 1	Homo sapiens	191-209
8297011-3	1993	In this study, we compared the pH and salt requirements, as well as the heat stability, of bacterial and eukaryotic beta-galactosidase in order to identify conditions which would inhibit the beta-galactosidase enzyme endogenous to eukaryotic cells without adversely affecting the activity of either purified bacterial beta-galactosidase or reporter beta-galactosidase produced after transfection of expression vectors into eukaryotic cells.	Salts	38-42	galactosidase beta 1	Homo sapiens	191-209
8272411-1	1993	The effect of salts (KI, KBr, NaCl, KCl, KF, phosphate, and Na2SO4) on the stability of beta-galactosidase in aqueous solution was studied from the aspect of changes in water mobility.	Sodium Chloride	30-34	galactosidase beta 1	Homo sapiens	88-106
8223076-0	1993	Comparative effects of exogenous lactase (beta-galactosidase) preparations on in vivo lactose digestion.	Lactose	86-93	galactosidase beta 1	Homo sapiens	42-60
8223076-1	1993	Microbial-derived beta-galactosidase (beta-gal) enzyme preparations improve in vivo lactose digestion and tolerance through enhanced gastrointestinal digestion of lactose.	Lactose	84-91	galactosidase beta 1	Homo sapiens	18-36
8223076-1	1993	Microbial-derived beta-galactosidase (beta-gal) enzyme preparations improve in vivo lactose digestion and tolerance through enhanced gastrointestinal digestion of lactose.	Lactose	84-91	galactosidase beta 1	Homo sapiens	18-26
8223076-1	1993	Microbial-derived beta-galactosidase (beta-gal) enzyme preparations improve in vivo lactose digestion and tolerance through enhanced gastrointestinal digestion of lactose.	Lactose	163-170	galactosidase beta 1	Homo sapiens	18-36
8223076-1	1993	Microbial-derived beta-galactosidase (beta-gal) enzyme preparations improve in vivo lactose digestion and tolerance through enhanced gastrointestinal digestion of lactose.	Lactose	163-170	galactosidase beta 1	Homo sapiens	18-26
8223076-8	1993	The 50-g lactose dose appeared to overwhelm the ability of either 3000 or 6000 IU of beta-gal to assist significantly with lactose digestion.	Lactose	123-130	galactosidase beta 1	Homo sapiens	85-93
8286122-7	1993	Digestion of ZP3 with endo-beta-galactosidase, an enzyme that trims polylactosamines, enhanced its affinity for membrane receptors.	polylactosamine	68-84	galactosidase beta 1	Homo sapiens	27-45
8272411-0	1993	The effect of salts on the stability of beta-galactosidase in aqueous solution, as related to the water mobility.	Water	98-103	galactosidase beta 1	Homo sapiens	40-58
8272411-1	1993	The effect of salts (KI, KBr, NaCl, KCl, KF, phosphate, and Na2SO4) on the stability of beta-galactosidase in aqueous solution was studied from the aspect of changes in water mobility.	KS I	21-23	galactosidase beta 1	Homo sapiens	88-106
8272411-1	1993	The effect of salts (KI, KBr, NaCl, KCl, KF, phosphate, and Na2SO4) on the stability of beta-galactosidase in aqueous solution was studied from the aspect of changes in water mobility.	Potassium Chloride	36-39	galactosidase beta 1	Homo sapiens	88-106
8272411-1	1993	The effect of salts (KI, KBr, NaCl, KCl, KF, phosphate, and Na2SO4) on the stability of beta-galactosidase in aqueous solution was studied from the aspect of changes in water mobility.	lysylphenylalanine	41-43	galactosidase beta 1	Homo sapiens	88-106
8272411-1	1993	The effect of salts (KI, KBr, NaCl, KCl, KF, phosphate, and Na2SO4) on the stability of beta-galactosidase in aqueous solution was studied from the aspect of changes in water mobility.	Phosphates	45-54	galactosidase beta 1	Homo sapiens	88-106
8272411-1	1993	The effect of salts (KI, KBr, NaCl, KCl, KF, phosphate, and Na2SO4) on the stability of beta-galactosidase in aqueous solution was studied from the aspect of changes in water mobility.	sodium sulfate	60-66	galactosidase beta 1	Homo sapiens	88-106
8272411-1	1993	The effect of salts (KI, KBr, NaCl, KCl, KF, phosphate, and Na2SO4) on the stability of beta-galactosidase in aqueous solution was studied from the aspect of changes in water mobility.	Water	169-174	galactosidase beta 1	Homo sapiens	88-106
8272411-2	1993	At salt concentrations up to 200 mM, the inactivation rate of beta-galactosidase in all the salt solutions studied increased with increasing salt concentration.	Salts	3-7	galactosidase beta 1	Homo sapiens	62-80
8272411-2	1993	At salt concentrations up to 200 mM, the inactivation rate of beta-galactosidase in all the salt solutions studied increased with increasing salt concentration.	Salts	92-96	galactosidase beta 1	Homo sapiens	62-80
8272411-2	1993	At salt concentrations up to 200 mM, the inactivation rate of beta-galactosidase in all the salt solutions studied increased with increasing salt concentration.	Salts	92-96	galactosidase beta 1	Homo sapiens	62-80
8272411-3	1993	At higher concentrations, those salts which had little effect on the spin-lattice relaxation time, T1, of water (KI, KBr, and KCl) continued to increase the inactivation rate of beta-galactosidase with increasing concentration, while those salts which decreased the T1 of water (KF, phosphate, and Na2SO4) decreased the inactivation rate.	Water	106-111	galactosidase beta 1	Homo sapiens	178-196
8272411-3	1993	At higher concentrations, those salts which had little effect on the spin-lattice relaxation time, T1, of water (KI, KBr, and KCl) continued to increase the inactivation rate of beta-galactosidase with increasing concentration, while those salts which decreased the T1 of water (KF, phosphate, and Na2SO4) decreased the inactivation rate.	Potassium Chloride	126-129	galactosidase beta 1	Homo sapiens	178-196
8272411-3	1993	At higher concentrations, those salts which had little effect on the spin-lattice relaxation time, T1, of water (KI, KBr, and KCl) continued to increase the inactivation rate of beta-galactosidase with increasing concentration, while those salts which decreased the T1 of water (KF, phosphate, and Na2SO4) decreased the inactivation rate.	Water	272-277	galactosidase beta 1	Homo sapiens	178-196
8272411-3	1993	At higher concentrations, those salts which had little effect on the spin-lattice relaxation time, T1, of water (KI, KBr, and KCl) continued to increase the inactivation rate of beta-galactosidase with increasing concentration, while those salts which decreased the T1 of water (KF, phosphate, and Na2SO4) decreased the inactivation rate.	lysylphenylalanine	279-281	galactosidase beta 1	Homo sapiens	178-196
8272411-3	1993	At higher concentrations, those salts which had little effect on the spin-lattice relaxation time, T1, of water (KI, KBr, and KCl) continued to increase the inactivation rate of beta-galactosidase with increasing concentration, while those salts which decreased the T1 of water (KF, phosphate, and Na2SO4) decreased the inactivation rate.	Phosphates	283-292	galactosidase beta 1	Homo sapiens	178-196
8272411-3	1993	At higher concentrations, those salts which had little effect on the spin-lattice relaxation time, T1, of water (KI, KBr, and KCl) continued to increase the inactivation rate of beta-galactosidase with increasing concentration, while those salts which decreased the T1 of water (KF, phosphate, and Na2SO4) decreased the inactivation rate.	sodium sulfate	298-304	galactosidase beta 1	Homo sapiens	178-196
8272411-4	1993	It appeared that the decrease in water mobility caused by KF, phosphate, and Na2SO4 resulted in stabilization of beta-galactosidase.	Water	33-38	galactosidase beta 1	Homo sapiens	113-131
8272411-4	1993	It appeared that the decrease in water mobility caused by KF, phosphate, and Na2SO4 resulted in stabilization of beta-galactosidase.	lysylphenylalanine	58-60	galactosidase beta 1	Homo sapiens	113-131
8272411-4	1993	It appeared that the decrease in water mobility caused by KF, phosphate, and Na2SO4 resulted in stabilization of beta-galactosidase.	Phosphates	62-71	galactosidase beta 1	Homo sapiens	113-131
8272411-4	1993	It appeared that the decrease in water mobility caused by KF, phosphate, and Na2SO4 resulted in stabilization of beta-galactosidase.	sodium sulfate	77-83	galactosidase beta 1	Homo sapiens	113-131
8474169-5	1993	The virus also was treated with neuraminidase or endo-beta-galactosidase to remove terminal sialic acids.	Sialic Acids	92-104	galactosidase beta 1	Homo sapiens	54-72
8104788-5	1993	The location of the fucose residues in the monofucosylated and difucosylated intermediate products was assessed by analyzing the digests obtained after endo-beta-galactosidase treatment by HPLC and reverse-phase chromatography.	Fucose	20-26	galactosidase beta 1	Homo sapiens	157-175
8393917-4	1993	Of several metals tested for beta-galactosidase induction and also for their toxicity to HEL cells, Zn was found to be the most suitable for use as an inducer.	Zinc	100-102	galactosidase beta 1	Homo sapiens	29-47
8393917-5	1993	In HEL cells infected with the recombinant in the presence of 50 microsM-Zn, beta-galactosidase activity was maximal 3 days after infection, and reached levels 27 times higher than the value obtained in the absence of Zn.	Zinc	73-75	galactosidase beta 1	Homo sapiens	77-95
8393917-5	1993	In HEL cells infected with the recombinant in the presence of 50 microsM-Zn, beta-galactosidase activity was maximal 3 days after infection, and reached levels 27 times higher than the value obtained in the absence of Zn.	Zinc	218-220	galactosidase beta 1	Homo sapiens	77-95
8481920-5	1993	Parental MCF-7 cells were transfected with an expression vector for beta-galactosidase, conferring the ability to convert the chromogenic substrate, 5-bromo-4-chloro-3-indoyl-beta-galactoside, to a blue color and allowing the detection of their presence within tumors developing after coinoculation with fibroblast growth factor 4-transfected cells.	5-bromo-4-chloro-3-indoyl-beta-galactoside	149-191	galactosidase beta 1	Homo sapiens	68-86
8227283-2	1993	We report here the identification and exact quantitation of cells infected by these mutants using an assay based on the reaction of intracellular beta-galactosidase expressed during infection by the recombinant viruses with the fluorogenic substrate fluorescein di-beta-D-galactopyranoside (FDG) followed by detection of positive cells in flow cytometry (FACS-Gal assay; Nolan et al., 1988).	Fluorescein	250-261	galactosidase beta 1	Homo sapiens	146-164
8227283-2	1993	We report here the identification and exact quantitation of cells infected by these mutants using an assay based on the reaction of intracellular beta-galactosidase expressed during infection by the recombinant viruses with the fluorogenic substrate fluorescein di-beta-D-galactopyranoside (FDG) followed by detection of positive cells in flow cytometry (FACS-Gal assay; Nolan et al., 1988).	-d-galactopyranoside	269-289	galactosidase beta 1	Homo sapiens	146-164
8227283-2	1993	We report here the identification and exact quantitation of cells infected by these mutants using an assay based on the reaction of intracellular beta-galactosidase expressed during infection by the recombinant viruses with the fluorogenic substrate fluorescein di-beta-D-galactopyranoside (FDG) followed by detection of positive cells in flow cytometry (FACS-Gal assay; Nolan et al., 1988).	fluorescein-digalactoside	291-294	galactosidase beta 1	Homo sapiens	146-164
8360503-5	1993	Released beta-gal activity was assayed sensitively by using 4-methylumbelliferyl-beta-D-galactoside, a fluorescent substrate.	4-methylumbelliferyl-galactopyranoside	60-99	galactosidase beta 1	Homo sapiens	9-17
8276424-0	1993	Evidence for beta-galactosidase catalyzed hydrolysis of paranitrophenyl-beta-D-galactopyranoside anchored in cyclodextrins.	paranitrophenyl-beta-d-galactopyranoside	56-96	galactosidase beta 1	Homo sapiens	13-31
8276424-0	1993	Evidence for beta-galactosidase catalyzed hydrolysis of paranitrophenyl-beta-D-galactopyranoside anchored in cyclodextrins.	Cyclodextrins	109-122	galactosidase beta 1	Homo sapiens	13-31
8384712-2	1993	When asialoorosomucoid conjugated with poly(L-lysine) was used to deliver the Escherichia coli beta-galactosidase gene into primary hepatocytes through binding with the hepatic asialoglycoprotein receptor, only a low level of beta-galactosidase was detectable, with less than 0.1% of the hepatocytes being transfected.	poly(l-lysine)	39-53	galactosidase beta 1	Homo sapiens	95-113
8321832-2	1993	Freeze-dried beta-galactosidase aggregated during storage in the presence of moisture, producing a protein precipitate which was soluble in guanidine hydrochloride solution but not in buffer solution.	Guanidine	140-163	galactosidase beta 1	Homo sapiens	13-31
8321832-8	1993	We propose that inactivation of beta-galactosidase is due to formation of thermally denatured (unfolded) protein, which aggregates dependent on the water:protein ratio, either via noncovalent interactions at a high water:protein ratio in solution or via covalent interaction at a low water:protein ratio in the freeze-dried state.	Water	148-153	galactosidase beta 1	Homo sapiens	32-50
8321832-8	1993	We propose that inactivation of beta-galactosidase is due to formation of thermally denatured (unfolded) protein, which aggregates dependent on the water:protein ratio, either via noncovalent interactions at a high water:protein ratio in solution or via covalent interaction at a low water:protein ratio in the freeze-dried state.	Water	215-220	galactosidase beta 1	Homo sapiens	32-50
8321832-8	1993	We propose that inactivation of beta-galactosidase is due to formation of thermally denatured (unfolded) protein, which aggregates dependent on the water:protein ratio, either via noncovalent interactions at a high water:protein ratio in solution or via covalent interaction at a low water:protein ratio in the freeze-dried state.	Water	215-220	galactosidase beta 1	Homo sapiens	32-50
8460481-5	1993	Viral vectors using neomycin, beta-galactosidase, and luciferase reporters have been employed to show that RBS-mediated repression occurs in EC and embryonal stem, but not in other tested cell types.	Roussin's Black Salt	107-110	galactosidase beta 1	Homo sapiens	30-48
8494924-5	1993	Preinjection of muscles with a relatively large volume of hypertonic sucrose improves the distribution of injected substances and results in significantly less variable expression of reporter genes for luciferase or beta-galactosidase; the coefficient of variation for mean luciferase activity was reduced from about 120% to 25%.	Sucrose	69-76	galactosidase beta 1	Homo sapiens	216-234
8384712-2	1993	When asialoorosomucoid conjugated with poly(L-lysine) was used to deliver the Escherichia coli beta-galactosidase gene into primary hepatocytes through binding with the hepatic asialoglycoprotein receptor, only a low level of beta-galactosidase was detectable, with less than 0.1% of the hepatocytes being transfected.	poly(l-lysine)	39-53	galactosidase beta 1	Homo sapiens	226-244
8485578-2	1993	Ad.RSV beta gal transferred beta-galactosidase to ependymal cells lining the ventricles whereas Ad-alpha 1AT mediated alpha 1-antitrypsin secretion into the cerebral spinal fluid for 1 week.	rsv beta gal	3-15	galactosidase beta 1	Homo sapiens	28-46
8444888-6	1993	Sialylated polylactosamine structures were identified and quantified by analyzing high performance liquid chromatography profiles of oligosaccharides first released by peptide-N4-(N-acetyl-beta-D-glucosaminyl)asparagine amidase and then treated with endo-beta-galactosidase, using a single, stained band of recombinant erythropoietin.	polylactosamine	11-26	galactosidase beta 1	Homo sapiens	255-273
8485578-3	1993	These observations, together with beta-galactosidase activity in the globus pallidus and substantia nigra following stereotactic administration of Ad.RSV beta gal to the globus pallidus, suggest that adenovirus vectors will be useful for CNS gene therapy.	rsv beta gal	150-162	galactosidase beta 1	Homo sapiens	34-52
8434801-7	1993	The other 24 oligosaccharides were derived by subsequent digestion of the 16 original oligosaccharides with beta-galactosidase or alpha-fucosidase.	Oligosaccharides	13-29	galactosidase beta 1	Homo sapiens	108-126
7763472-1	1993	The effect of temperature and O2 saturation on the production of recombinant proteins beta-galactosidase and human glucocerebrosidase by Spodoptera frugiperda cells (Sf9) infected with recombinant Autographa californica nuclear polyhedrosis virus was investigated.	Oxygen	30-32	galactosidase beta 1	Homo sapiens	86-104
8430108-10	1993	We show that avidin, streptavidin, or polyclonal anti-biotin (but not a monoclonal anti-biotin) antibody is capable of specifically capturing in vivo biotinylated beta-galactosidase and c-Jun and that this capture is dependent upon the presence of both avidin and the BCCP moiety.	Biotin	54-60	galactosidase beta 1	Homo sapiens	163-181
1336374-6	1992	However, the level of beta-galactosidase from cells transfected with pUCLN beta-4 was not affected by viral infection.	pucln	69-74	galactosidase beta 1	Homo sapiens	22-40
8288080-7	1993	beta-gal activity was measured in fecal extracts by its ability to hydrolyze paranitrophenyl beta-D-galactopyranoside and expressed as units of enzymatic activity/gram of fecal proteins.	paranitrophenyl beta-d-galactopyranoside	77-117	galactosidase beta 1	Homo sapiens	0-8
8430045-2	1993	Inactivation of beta-galactosidase lyophilized from phosphate buffer solution was studied as a function of water content, which in turn affected the T1 of water.	Phosphates	52-61	galactosidase beta 1	Homo sapiens	16-34
8430045-2	1993	Inactivation of beta-galactosidase lyophilized from phosphate buffer solution was studied as a function of water content, which in turn affected the T1 of water.	Water	107-112	galactosidase beta 1	Homo sapiens	16-34
8430045-2	1993	Inactivation of beta-galactosidase lyophilized from phosphate buffer solution was studied as a function of water content, which in turn affected the T1 of water.	Water	155-160	galactosidase beta 1	Homo sapiens	16-34
8430045-3	1993	An increase in the water content of freeze-dried beta-galactosidase brought about an increase in the T1 of water, as well as a rise in pH.	Water	19-24	galactosidase beta 1	Homo sapiens	49-67
8430045-3	1993	An increase in the water content of freeze-dried beta-galactosidase brought about an increase in the T1 of water, as well as a rise in pH.	Water	107-112	galactosidase beta 1	Homo sapiens	49-67
8430045-7	1993	Inactivation of beta-galactosidase in solutions was also studied as a function of phosphate buffer and sodium chloride concentrations, which in turn affected the T1 of water.	Phosphates	82-91	galactosidase beta 1	Homo sapiens	16-34
8430045-7	1993	Inactivation of beta-galactosidase in solutions was also studied as a function of phosphate buffer and sodium chloride concentrations, which in turn affected the T1 of water.	Sodium Chloride	103-118	galactosidase beta 1	Homo sapiens	16-34
8430045-7	1993	Inactivation of beta-galactosidase in solutions was also studied as a function of phosphate buffer and sodium chloride concentrations, which in turn affected the T1 of water.	Water	168-173	galactosidase beta 1	Homo sapiens	16-34
1487516-3	1992	Over-expressed Ck-beta-galactosidase fusion protein was purified using monoclonal antibodies immobilised on Sepharose 4B.	Sepharose	108-117	galactosidase beta 1	Homo sapiens	18-36
8449258-13	1993	This effect was most pronounced in the beta-galactosidase activity which increased from 50 U/mg crea.	crea	75-79	galactosidase beta 1	Homo sapiens	39-57
8449258-17	1993	In the case of the beta-galactosidase a significant rise from 68 to 310 U/mg crea.	crea	77-81	galactosidase beta 1	Homo sapiens	19-37
1328669-5	1992	The broad size distribution of GL results from heterogeneous N-acetyllactosamine addition since it is susceptible to digestion by endo-beta-galactosidase.	glycylleucine	31-33	galactosidase beta 1	Homo sapiens	135-153
1299558-8	1992	The fusion protein was purified by affinity chromatography on an anti-beta-galactosidase-Sepharose column.	Sepharose	89-98	galactosidase beta 1	Homo sapiens	70-88
1328669-5	1992	The broad size distribution of GL results from heterogeneous N-acetyllactosamine addition since it is susceptible to digestion by endo-beta-galactosidase.	N-acetyllactosamine	61-80	galactosidase beta 1	Homo sapiens	135-153
1444312-2	1992	In all of the non-TA-producing mutants, the beta-galactosidase specific activity was higher when the cells were grown in nutrient-limited 0.5CTS medium (0.5% Casitone plus alanine, serine, and glucose) than in rich 2CT medium (2% Casitone).	Tantalum	18-20	galactosidase beta 1	Homo sapiens	44-62
1444312-2	1992	In all of the non-TA-producing mutants, the beta-galactosidase specific activity was higher when the cells were grown in nutrient-limited 0.5CTS medium (0.5% Casitone plus alanine, serine, and glucose) than in rich 2CT medium (2% Casitone).	0.5cts medium	138-151	galactosidase beta 1	Homo sapiens	44-62
1444312-2	1992	In all of the non-TA-producing mutants, the beta-galactosidase specific activity was higher when the cells were grown in nutrient-limited 0.5CTS medium (0.5% Casitone plus alanine, serine, and glucose) than in rich 2CT medium (2% Casitone).	Alanine	172-179	galactosidase beta 1	Homo sapiens	44-62
1444312-2	1992	In all of the non-TA-producing mutants, the beta-galactosidase specific activity was higher when the cells were grown in nutrient-limited 0.5CTS medium (0.5% Casitone plus alanine, serine, and glucose) than in rich 2CT medium (2% Casitone).	Serine	181-187	galactosidase beta 1	Homo sapiens	44-62
1444312-2	1992	In all of the non-TA-producing mutants, the beta-galactosidase specific activity was higher when the cells were grown in nutrient-limited 0.5CTS medium (0.5% Casitone plus alanine, serine, and glucose) than in rich 2CT medium (2% Casitone).	Glucose	193-200	galactosidase beta 1	Homo sapiens	44-62
1444312-2	1992	In all of the non-TA-producing mutants, the beta-galactosidase specific activity was higher when the cells were grown in nutrient-limited 0.5CTS medium (0.5% Casitone plus alanine, serine, and glucose) than in rich 2CT medium (2% Casitone).	2ct medium	215-225	galactosidase beta 1	Homo sapiens	44-62
1444312-6	1992	The beta-galactosidase specific activities of both strains increased greatly when the cells were grown in the presence of magnesium phosphate, which traps ammonium ions.	magnesium phosphate	122-141	galactosidase beta 1	Homo sapiens	4-22
1444312-6	1992	The beta-galactosidase specific activities of both strains increased greatly when the cells were grown in the presence of magnesium phosphate, which traps ammonium ions.	Ammonium Compounds	155-163	galactosidase beta 1	Homo sapiens	4-22
1444312-8	1992	An N-methyl-N"-nitro-N-nitrosoguanidine-induced mutation in 1030 that mapped 17 kb from the omega 1010 insert increased the specific activity of beta-galactosidase 21 times in 2CT medium.	Methylnitronitrosoguanidine	3-39	galactosidase beta 1	Homo sapiens	145-163
1639820-6	1992	We describe conditions by which MPBH is coupled selectively to the sialic acid residues of sCD4, and exemplify the use of MPBH by conjugating sCD4 to hemoglobin and to beta-galactosidase.	4-(4-N-maleimidophenyl)butyric acid hydrazide	32-36	galactosidase beta 1	Homo sapiens	168-186
1429877-6	1992	The sensitivity of the high-M(r) oligosaccharides to endo-beta-galactosidase and their incorporation of [3H]glucosamine suggest that they could contain repeating N-acetyllactosamine units.	(r) oligosaccharides	29-49	galactosidase beta 1	Homo sapiens	58-76
1429877-6	1992	The sensitivity of the high-M(r) oligosaccharides to endo-beta-galactosidase and their incorporation of [3H]glucosamine suggest that they could contain repeating N-acetyllactosamine units.	N-acetyllactosamine	162-181	galactosidase beta 1	Homo sapiens	58-76
1518811-8	1992	Independent G418-resistant colonies from site-specific integration of the reporter gene all showed nearly identical levels of beta-galactosidase activity when the reporter construct integrated at a particular chromosomal position.	antibiotic G 418	12-16	galactosidase beta 1	Homo sapiens	126-144
1476723-1	1992	Free biotin was quantitated by a competition by coating biotin-bovine serum albumin conjugate on a polystyrene microplate for binding to avidin-beta-galactosidase conjugate.	Biotin	5-11	galactosidase beta 1	Homo sapiens	144-162
1526992-1	1992	A new type of endo-beta-galactosidase acting on the linkage region of peptidochondroitin sulfate was isolated from the mid-gut gland of the mollusk Patinopecten.	peptidochondroitin sulfate	70-96	galactosidase beta 1	Homo sapiens	19-37
1639820-6	1992	We describe conditions by which MPBH is coupled selectively to the sialic acid residues of sCD4, and exemplify the use of MPBH by conjugating sCD4 to hemoglobin and to beta-galactosidase.	4-(4-N-maleimidophenyl)butyric acid hydrazide	122-126	galactosidase beta 1	Homo sapiens	168-186
1378838-5	1992	Treatment of Band 3 with endo-beta-galactosidase that destroys the poly-N-acetyllactosaminyl sugar chain of Band 3 or with neuraminidase resulted in loss of the inhibitory activity.	poly-n-acetyllactosaminyl sugar	67-98	galactosidase beta 1	Homo sapiens	30-48
1497620-2	1992	GM1 ganglioside beta-galactosidase (beta-Gal) is deficient in the autosomal recessive disorder GM1 gangliosidosis.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	16-34
1497620-2	1992	GM1 ganglioside beta-galactosidase (beta-Gal) is deficient in the autosomal recessive disorder GM1 gangliosidosis.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	36-44
1497620-4	1992	Affinity chromatography of beta-Gal on p-aminophenylthiogalactose-Sepharose (PATG-Sepharose) at pH 4.3, the pH optimum of beta-Gal, resulted in a 260-fold enrichment of beta-Gal, but the major protein in the fraction had an M(r) value of 74,000.	p-aminophenylthiogalactose-sepharose	39-75	galactosidase beta 1	Homo sapiens	27-35
1497620-4	1992	Affinity chromatography of beta-Gal on p-aminophenylthiogalactose-Sepharose (PATG-Sepharose) at pH 4.3, the pH optimum of beta-Gal, resulted in a 260-fold enrichment of beta-Gal, but the major protein in the fraction had an M(r) value of 74,000.	p-aminophenylthiogalactose-sepharose	39-75	galactosidase beta 1	Homo sapiens	122-130
1497620-4	1992	Affinity chromatography of beta-Gal on p-aminophenylthiogalactose-Sepharose (PATG-Sepharose) at pH 4.3, the pH optimum of beta-Gal, resulted in a 260-fold enrichment of beta-Gal, but the major protein in the fraction had an M(r) value of 74,000.	p-aminophenylthiogalactose-sepharose	39-75	galactosidase beta 1	Homo sapiens	122-130
1497620-4	1992	Affinity chromatography of beta-Gal on p-aminophenylthiogalactose-Sepharose (PATG-Sepharose) at pH 4.3, the pH optimum of beta-Gal, resulted in a 260-fold enrichment of beta-Gal, but the major protein in the fraction had an M(r) value of 74,000.	patg-sepharose	77-91	galactosidase beta 1	Homo sapiens	27-35
1497620-4	1992	Affinity chromatography of beta-Gal on p-aminophenylthiogalactose-Sepharose (PATG-Sepharose) at pH 4.3, the pH optimum of beta-Gal, resulted in a 260-fold enrichment of beta-Gal, but the major protein in the fraction had an M(r) value of 74,000.	patg-sepharose	77-91	galactosidase beta 1	Homo sapiens	122-130
1497620-4	1992	Affinity chromatography of beta-Gal on p-aminophenylthiogalactose-Sepharose (PATG-Sepharose) at pH 4.3, the pH optimum of beta-Gal, resulted in a 260-fold enrichment of beta-Gal, but the major protein in the fraction had an M(r) value of 74,000.	patg-sepharose	77-91	galactosidase beta 1	Homo sapiens	122-130
1497620-5	1992	Affinity chromatography on PATG-Sepharose at pH 5.2 showed substantial enrichment (4000-fold) of beta-Gal, and the mature form of the enzyme (M(r) 64,000) was the major protein in the preparation.	patg-sepharose	27-41	galactosidase beta 1	Homo sapiens	97-105
1378838-7	1992	Endo-beta-galactosidase and neuraminidase destroyed the activity of the oligosaccharides, but alpha-L-fucosidase did not.	Oligosaccharides	72-88	galactosidase beta 1	Homo sapiens	5-23
1378838-8	1992	Furthermore, human lactoferrin that contains sialylated two N-acetyllactosaminyl units also exhibited potent inhibitory activity, and the activity was destroyed by endo-beta-galactosidase and neuraminidase.	n-acetyllactosaminyl	60-80	galactosidase beta 1	Homo sapiens	169-187
1572395-9	1992	5-Aza-CR, the specific isopropyl beta-D-thiogalactoside inducer, and heavy metal ions added together trigger an increase of the beta-galactosidase activity up to 600-fold over the basal level.	Azacitidine	0-8	galactosidase beta 1	Homo sapiens	128-146
1572395-9	1992	5-Aza-CR, the specific isopropyl beta-D-thiogalactoside inducer, and heavy metal ions added together trigger an increase of the beta-galactosidase activity up to 600-fold over the basal level.	Isopropyl Thiogalactoside	23-55	galactosidase beta 1	Homo sapiens	128-146
1572395-9	1992	5-Aza-CR, the specific isopropyl beta-D-thiogalactoside inducer, and heavy metal ions added together trigger an increase of the beta-galactosidase activity up to 600-fold over the basal level.	Metals	75-80	galactosidase beta 1	Homo sapiens	128-146
1607386-1	1992	We used bacterially expressed beta-galactosidase fusion proteins to localize the phospholipid binding domain of Acanthamoeba myosin IC to the region between amino acids 701 and 888 in the NH2-terminal half of the tail.	Phospholipids	81-93	galactosidase beta 1	Homo sapiens	30-48
1324885-7	1992	Ubiquitin showed a slow intrinsic proteolytic activity against SDS-denatured beta-galactosidase in the absence of ATP.	Sodium Dodecyl Sulfate	63-66	galactosidase beta 1	Homo sapiens	77-95
1616704-0	1992	Magnesium chelation inactivates beta-galactosidase in -20 degrees C storage.	Magnesium	0-9	galactosidase beta 1	Homo sapiens	32-50
1560532-8	1992	Addition of increasing amounts of IPTG induced expression of beta-galactosidase to the point of suppression of viral replication.	Isopropyl Thiogalactoside	34-38	galactosidase beta 1	Homo sapiens	61-79
1347041-4	1992	Immunoprecipitated full-length P-glycoprotein beta-galactosidase showed ATPase activity with apparent specific activity of 180 nmol/mg/min, a value higher than previously reported, in the presence of phospholipids, suggesting that stabilization of the transmembrane domains is necessary for ATP hydrolysis.	Phospholipids	200-213	galactosidase beta 1	Homo sapiens	46-64
1347041-4	1992	Immunoprecipitated full-length P-glycoprotein beta-galactosidase showed ATPase activity with apparent specific activity of 180 nmol/mg/min, a value higher than previously reported, in the presence of phospholipids, suggesting that stabilization of the transmembrane domains is necessary for ATP hydrolysis.	Adenosine Triphosphate	72-75	galactosidase beta 1	Homo sapiens	46-64
1347041-5	1992	N-terminal half P-glycoprotein-beta-galactosidase also showed ability to hydrolyze ATP but with slightly lower specific activity.	Adenosine Triphosphate	83-86	galactosidase beta 1	Homo sapiens	31-49
1616704-6	1992	Storage of cell lysate at -70 degrees C completely prevents the EDTA-induced inactivation of beta Gal.	Edetic Acid	64-68	galactosidase beta 1	Homo sapiens	93-101
1373671-2	1992	We have generated a monoclonal antibody (MAb), designated DF3-P, against a recombinant DF3/beta-galactosidase fusion protein.	df3-p	58-63	galactosidase beta 1	Homo sapiens	91-109
1606711-1	1992	A 23-nucleotide tandem duplication (GGACCTTGAAAGTACTC-GGGACC) was found within exon 3 of the beta-galactosidase gene in a patient with infantile-form GM1-gangliosidosis, which generated a premature stop codon after translation of 36 amino acids.	23-nucleotide	2-15	galactosidase beta 1	Homo sapiens	93-111
1352240-3	1992	We analyse beta-galactosidase patterns in imaginal discs conferred by each individual Ubx control region.	N-[(S)-({[(Benzyloxy)carbonyl]amino}methyl)(Hydroxy)phosphoryl]-N-Methyl-L-Leucinamide	86-89	galactosidase beta 1	Homo sapiens	11-29
1616704-1	1992	Mammalian cell lysate containing beta-galactosidase (beta Gal) derived from the transient expression of the bacterial lacZ gene driven by the human beta-actin promoter loses activity progressively over time in storage at -20 degrees C in the presence of EDTA.	Edetic Acid	254-258	galactosidase beta 1	Homo sapiens	33-51
1616704-1	1992	Mammalian cell lysate containing beta-galactosidase (beta Gal) derived from the transient expression of the bacterial lacZ gene driven by the human beta-actin promoter loses activity progressively over time in storage at -20 degrees C in the presence of EDTA.	Edetic Acid	254-258	galactosidase beta 1	Homo sapiens	53-61
1616704-5	1992	Therefore, the chelation of Mg2+ by EDTA at -20 degrees C inactivates beta Gal.	magnesium ion	28-32	galactosidase beta 1	Homo sapiens	70-78
1616704-5	1992	Therefore, the chelation of Mg2+ by EDTA at -20 degrees C inactivates beta Gal.	Edetic Acid	36-40	galactosidase beta 1	Homo sapiens	70-78
1380848-1	1992	beta-galactosidase, revealed by an indigo blue reaction product, represents a valid tracer in immunohistochemistry.	Indigo Carmine	35-46	galactosidase beta 1	Homo sapiens	0-18
1546393-2	1992	The sample"s drug reacts with an excess of an antidigoxin Fab"-beta-galactosidase monoconjugate and then the free monoconjugate is removed by polyacrylamide digitoxigenin-coupled beads; the beta-galactosidase activity of the supernatant measured photometrically at 634 nm is directly proportional to the digoxin concentration in the sample.	polyacrylamide	142-156	galactosidase beta 1	Homo sapiens	190-208
1546393-2	1992	The sample"s drug reacts with an excess of an antidigoxin Fab"-beta-galactosidase monoconjugate and then the free monoconjugate is removed by polyacrylamide digitoxigenin-coupled beads; the beta-galactosidase activity of the supernatant measured photometrically at 634 nm is directly proportional to the digoxin concentration in the sample.	Digitoxigenin	157-170	galactosidase beta 1	Homo sapiens	190-208
1547204-0	1992	Enhancement of intestinal hydrolysis of lactose by microbial beta-galactosidase (EC 3.2.1.23) of kefir.	Lactose	40-47	galactosidase beta 1	Homo sapiens	61-79
1547204-1	1992	The effect of microbial beta-galactosidase (EC 3.2.1.23) activity on intestinal lactose digestion was estimated directly by following post-prandial venous plasma galactose concentrations.	Lactose	80-87	galactosidase beta 1	Homo sapiens	24-42
1547204-4	1992	Feeding kefir with beta-galactosidase activity resulted in a 30% enhancement of the mean post-prandial plasma galactose peak concentration from 33 (SEM 7) to 43 (SEM 12) mumol/l (n 10), as well as in 23% greater mean areas under the galactose-response curves (8.1 (SEM 1.5) v. 6.6 (SEM 1.2) mmol/min per l) if compared with kefir with heat-treated grains.	Galactose	110-119	galactosidase beta 1	Homo sapiens	19-37
1547204-4	1992	Feeding kefir with beta-galactosidase activity resulted in a 30% enhancement of the mean post-prandial plasma galactose peak concentration from 33 (SEM 7) to 43 (SEM 12) mumol/l (n 10), as well as in 23% greater mean areas under the galactose-response curves (8.1 (SEM 1.5) v. 6.6 (SEM 1.2) mmol/min per l) if compared with kefir with heat-treated grains.	Galactose	233-242	galactosidase beta 1	Homo sapiens	19-37
1547204-7	1992	These results give direct evidence of an enhanced lactose digestion and absorption in native fermented milk products due to the microbial beta-galactosidase activity.	Lactose	50-57	galactosidase beta 1	Homo sapiens	138-156
1546393-2	1992	The sample"s drug reacts with an excess of an antidigoxin Fab"-beta-galactosidase monoconjugate and then the free monoconjugate is removed by polyacrylamide digitoxigenin-coupled beads; the beta-galactosidase activity of the supernatant measured photometrically at 634 nm is directly proportional to the digoxin concentration in the sample.	Digoxin	50-57	galactosidase beta 1	Homo sapiens	63-81
1309289-2	1992	PGD2 and PGE2 binding activities were significantly decreased by pretreatment with various exoglycosidases, such as neuraminidase for PGE2 binding, alpha-mannosidase and beta-galactosidase for PGD2 binding, and beta-N-acetylhexosaminidase for both.	Dinoprostone	9-13	galactosidase beta 1	Homo sapiens	170-188
1380848-4	1992	In addition, we propose a sensitive alternative staining procedure for beta-galactosidase, based on TNBT reduction and precipitation.	Tetranitroblue tetrazolium chloride	100-104	galactosidase beta 1	Homo sapiens	71-89
1809326-2	1991	The chromogenic substrate, CPRG (chlorophenol red-beta-D-galactopyranoside), was compared with ONPG (o-nitrophenyl-beta-D-galactopyranoside) by kinetic analysis with purified beta-galactosidase.	chlorophenol red galactopyranoside	27-31	galactosidase beta 1	Homo sapiens	175-193
1924305-3	1991	The enzymatic activity was specific for a uracil-containing polynucleotide substrate and was inhibited by a glycosylase antibody or a beta-galactosidase antibody.	Uracil	42-48	galactosidase beta 1	Homo sapiens	134-152
1807155-1	1991	An optimized chemiluminescent assay for beta-galactosidase using a chemiluminescent substrate AMPGD (3-(4-methoxyspiro[1,2-dioxetane-3,2"-tricyclo-[3.3.1.	3-(4-methoxyspiro[1,2-dioxetane-3,2"-tricyclo-[3	101-149	galactosidase beta 1	Homo sapiens	40-58
1718960-2	1991	A cDNA encoding human platelet 5-phosphatase has been isolated by screening for beta-galactosidase fusion proteins that bind to inositol 1,3,4,5-tetrakisphosphate.	inositol-1,3,4,5-tetrakisphosphate	128-162	galactosidase beta 1	Homo sapiens	80-98
1657976-9	1991	Analysis of the size of cell surface complex-type glycopeptides before and after digestion with neuraminidase and endo-beta-galactosidase suggested an increased sialic acid density, an increase in the number and/or length of polylactosaminoglycan chains, and an increased branching of the glycans upon N-ras induction.	N-Acetylneuraminic Acid	161-172	galactosidase beta 1	Homo sapiens	119-137
1924305-3	1991	The enzymatic activity was specific for a uracil-containing polynucleotide substrate and was inhibited by a glycosylase antibody or a beta-galactosidase antibody.	Polynucleotides	60-74	galactosidase beta 1	Homo sapiens	134-152
1907269-4	1991	An ecotropic, rodent-specific, replication-defective murine leukemia virus containing the gene for beta-galactosidase was chemically modified with lactose to contain 5.9 mumol of lactose per mg of viral RNA.	Lactose	179-186	galactosidase beta 1	Homo sapiens	99-117
1909565-0	1991	Kinetic assay of fluorescein mono-beta-D-galactoside hydrolysis by beta-galactosidase: a front-face measurement for strongly absorbing fluorogenic substrates.	Fluorescein	17-28	galactosidase beta 1	Homo sapiens	67-85
1909565-2	1991	Fluorescein mono-beta-D-galactoside (FMG) was chosen as the substrate for the fluorescence enzymatic assay because of the high fluorescence of its hydrolytic product (fluorescein) and suitability of being hydrolyzed by beta-galactosidase.	fluorescein monogalactoside	0-35	galactosidase beta 1	Homo sapiens	219-237
1909565-2	1991	Fluorescein mono-beta-D-galactoside (FMG) was chosen as the substrate for the fluorescence enzymatic assay because of the high fluorescence of its hydrolytic product (fluorescein) and suitability of being hydrolyzed by beta-galactosidase.	fluorescein monogalactoside	37-40	galactosidase beta 1	Homo sapiens	219-237
1909566-0	1991	Kinetic fluorescence measurement of fluorescein di-beta-D-galactoside hydrolysis by beta-galactosidase: intermediate channeling in stepwise catalysis by a free single enzyme.	Fluorescein	36-47	galactosidase beta 1	Homo sapiens	84-102
1909566-0	1991	Kinetic fluorescence measurement of fluorescein di-beta-D-galactoside hydrolysis by beta-galactosidase: intermediate channeling in stepwise catalysis by a free single enzyme.	Galactosides	58-69	galactosidase beta 1	Homo sapiens	84-102
1909566-1	1991	Kinetic fluorescence measurements were employed to quantitative to stepwise hydrolysis of fluorescein di-beta-D-galactoside (FDG) by beta-galactosidase and the intermediate fluorescein mono-beta-D-galactoside (FMG) channeling.	fluorescein-digalactoside	90-123	galactosidase beta 1	Homo sapiens	133-151
1909566-1	1991	Kinetic fluorescence measurements were employed to quantitative to stepwise hydrolysis of fluorescein di-beta-D-galactoside (FDG) by beta-galactosidase and the intermediate fluorescein mono-beta-D-galactoside (FMG) channeling.	fluorescein-digalactoside	125-128	galactosidase beta 1	Homo sapiens	133-151
1909566-1	1991	Kinetic fluorescence measurements were employed to quantitative to stepwise hydrolysis of fluorescein di-beta-D-galactoside (FDG) by beta-galactosidase and the intermediate fluorescein mono-beta-D-galactoside (FMG) channeling.	fluorescein monogalactoside	210-213	galactosidase beta 1	Homo sapiens	133-151
1907269-11	1991	Histochemical treatment of cells with 5-bromo-4-chloro-3-indoyl beta-D-galactoside to detect in situ beta-galactosidase activity demonstrated that only HepG2 cells treated with modified virus were positive and that 36% of these cells were stained after 5 days.	5-bromo-4-chloro-3-indoyl beta-d-galactoside	38-82	galactosidase beta 1	Homo sapiens	101-119
1657302-2	1991	Virally infected neurons were visualized with a one-step histochemical reaction using the Bluo-Gal substrate (halogenated indolyl-beta-D-galactoside) for the localization of beta-galactosidase activity.	indolyl-beta-d-galactoside	122-148	galactosidase beta 1	Homo sapiens	174-192
1907570-2	1991	Tetraantennary oligosaccharides containing extra N-acetyllactosamine units were digested with endo-beta-galactosidase, followed by treatment with N-acetyl-beta-glucosaminidase, yielding products which could be analysed by 1H-NMR spectroscopy, thereby giving conclusive data about the location of the extra units in the intact structures.	Oligosaccharides	15-31	galactosidase beta 1	Homo sapiens	99-117
1907570-2	1991	Tetraantennary oligosaccharides containing extra N-acetyllactosamine units were digested with endo-beta-galactosidase, followed by treatment with N-acetyl-beta-glucosaminidase, yielding products which could be analysed by 1H-NMR spectroscopy, thereby giving conclusive data about the location of the extra units in the intact structures.	Hydrogen	222-224	galactosidase beta 1	Homo sapiens	99-117
1901822-7	1991	Resistance to Xyl-A/dCF was observed in the lines carrying ADA::lacZ and moreover, the fraction of cells that survived a stringent selection for ADA overexpression also exhibited significantly increased levels of beta Gal, which confirmed the direct linkage between ADA and lacZ expression.	9-xylosyladenine	14-19	galactosidase beta 1	Homo sapiens	213-221
1854798-4	1991	The minimal bile salt concentrations for optimal 1,4-beta-galactosidase activities varied between 1 and 20 mM, i.e., close to or above the critical micellar concentrations (cmc).	Bile Acids and Salts	12-21	galactosidase beta 1	Homo sapiens	53-71
1648227-4	1991	Both alpha- and beta-adrenergic agonists, dibutyryl cAMP, and phorbol ester induced beta-galactosidase activity in a dose-dependent manner.	Bucladesine	42-56	galactosidase beta 1	Homo sapiens	84-102
1648227-4	1991	Both alpha- and beta-adrenergic agonists, dibutyryl cAMP, and phorbol ester induced beta-galactosidase activity in a dose-dependent manner.	Phorbol Esters	62-75	galactosidase beta 1	Homo sapiens	84-102
1902576-5	1991	The activity of the intracellular lacZ enzyme was analyzed by flow cytometric measurement of fluorescein accumulation in cells loaded with the fluorogenic beta-galactosidase substrate fluorescein di-beta-D-galactopyranoside.	Fluorescein	93-104	galactosidase beta 1	Homo sapiens	155-173
1902576-5	1991	The activity of the intracellular lacZ enzyme was analyzed by flow cytometric measurement of fluorescein accumulation in cells loaded with the fluorogenic beta-galactosidase substrate fluorescein di-beta-D-galactopyranoside.	fluorescein-digalactoside	184-223	galactosidase beta 1	Homo sapiens	155-173
1907811-0	1991	Flow injection analysis of lactose using covalently immobilized beta-galactosidase, mutarotase, and glucose oxidase/peroxidase on a 2-fluoro-1-methylpyridinium salt-activated Fractogel support.	Lactose	27-34	galactosidase beta 1	Homo sapiens	64-82
1847270-2	1991	By using both synthetic peptides, containing small regions of Vp2/3 conjugated to bovine serum albumin (BSA), and beta-galactosidase-Vp3 fusion proteins, we have narrowed this nuclear transport signal (NTS) to 9 amino acids (198 to 206 of Vp3 or 316 to 324 of Vp2), Gly-Pro-Asn-Lys-Lys-Lys-Arg-Lys-Leu.	nts	202-205	galactosidase beta 1	Homo sapiens	114-132
18600703-2	1991	Invertase, beta-galactosidase, amyloglucosidase, mutarotase, and glucose oxidase were covalently immobilized on triacetyl cellulose membranes containing 1,8-diamino-4-aminomethyloctane.	cellulose triacetate	112-131	galactosidase beta 1	Homo sapiens	11-29
2021132-1	1991	Lactose in yogurt is better digested than lactose in other dairy foods by lactase-deficient individuals, in part because of intraintestinal activity of yogurt microbial beta-galactosidase (beta-gal).	Lactose	0-7	galactosidase beta 1	Homo sapiens	169-187
2021132-1	1991	Lactose in yogurt is better digested than lactose in other dairy foods by lactase-deficient individuals, in part because of intraintestinal activity of yogurt microbial beta-galactosidase (beta-gal).	Lactose	0-7	galactosidase beta 1	Homo sapiens	169-177
2021132-3	1991	To evaluate the ability of yogurt beta-gal to digest lactose when yogurt is consumed with food or with additional lactose, 22 healthy lactose-maldigesting individuals were fed 10 test meals.	Lactose	53-60	galactosidase beta 1	Homo sapiens	34-42
1657434-4	1991	The two glycolipids displayed comparable sensitivity to beta-galactosidase but differed from one another by their sensitivity to phosphatidylinositol-specific phospholipase C. Moreover, structural heterogeneity within each peak was suggested by their partial resistance to nitrous acid deamination.	Glycolipids	8-19	galactosidase beta 1	Homo sapiens	56-74
1367498-0	1991	Partitioning of beta-galactosidase fusion proteins in PEG/potassium phosphate aqueous two-phase systems.	Polyethylene Glycols	54-57	galactosidase beta 1	Homo sapiens	16-34
1367498-0	1991	Partitioning of beta-galactosidase fusion proteins in PEG/potassium phosphate aqueous two-phase systems.	potassium phosphate	58-77	galactosidase beta 1	Homo sapiens	16-34
1367498-5	1991	The compatibility with PEG and potassium phosphate of beta-galactosidase, SpA, and two different versions of the SpA beta gal protein, displayed as precipitation curves, showed a relationship to the protein partition coefficients in PEG/potassium phosphate systems.	potassium phosphate	31-50	galactosidase beta 1	Homo sapiens	54-72
1367498-5	1991	The compatibility with PEG and potassium phosphate of beta-galactosidase, SpA, and two different versions of the SpA beta gal protein, displayed as precipitation curves, showed a relationship to the protein partition coefficients in PEG/potassium phosphate systems.	Polyethylene Glycols	233-236	galactosidase beta 1	Homo sapiens	54-72
1367498-5	1991	The compatibility with PEG and potassium phosphate of beta-galactosidase, SpA, and two different versions of the SpA beta gal protein, displayed as precipitation curves, showed a relationship to the protein partition coefficients in PEG/potassium phosphate systems.	potassium phosphate	237-256	galactosidase beta 1	Homo sapiens	54-72
18597361-7	1991	The synthesis and degradation rates of beta-galactosidase were investigated by a pulse-chase technique using L-[(35)S]-methionine.	l-[(35)s]-methionine	109-129	galactosidase beta 1	Homo sapiens	39-57
1904815-6	1991	The method was applied to the analysis of the partial sequential degradation of a complex oligosaccharide with neuraminidase and beta-galactosidase.	Oligosaccharides	90-105	galactosidase beta 1	Homo sapiens	129-147
1905992-4	1991	This report details the following improvements of the original assay: 1) use of phenylethyl-beta-D-thiogalactoside, a competitive inhibitor, to inhibit beta-galactosidase activity; 2) reduction of false positives by two-color measurements; and 3) inhibition of interfering mammalian beta-galactosidases by the weak base chloroquine.	phenylethyl beta-d-thiogalactoside	80-114	galactosidase beta 1	Homo sapiens	152-170
1806363-2	1991	This fraction was distinct from those stimulating the hydrolysis of galactose from GM1 ganglioside by beta-galactosidase and the hydrolysis of N-acetylgalactosamine from GM2 ganglioside by hexosaminidase A.	Galactose	68-77	galactosidase beta 1	Homo sapiens	102-120
1806363-2	1991	This fraction was distinct from those stimulating the hydrolysis of galactose from GM1 ganglioside by beta-galactosidase and the hydrolysis of N-acetylgalactosamine from GM2 ganglioside by hexosaminidase A.	G(M1) Ganglioside	83-98	galactosidase beta 1	Homo sapiens	102-120
1901712-2	1991	Modification of the method, which is based on beta-galactosidase production, involves incorporation of a lactose operon inducer in medium upon which presumptive coliform isolates are cultured prior to beta-galactosidase assay.	Lactose	105-112	galactosidase beta 1	Homo sapiens	46-64
2127955-3	1990	Under isopropyl-beta-D-thiogalactopyranoside induction, a tripartite protein, consisting of beta-galactosidase, a collagenase recognition site, and AR polypeptide, was produced in E. coli JM109 using pSS20 a as a vector.	Isopropyl Thiogalactoside	6-44	galactosidase beta 1	Homo sapiens	92-110
1991474-9	1991	Treatment with beta-galactosidase, beta-N-acetylglucosaminidase and alpha-mannosidase resulted in a decrease of the oligosaccharide elution times corresponding to the number of sugar residues lost, the profile of changes was highly reproducible.	Oligosaccharides	116-131	galactosidase beta 1	Homo sapiens	15-33
1991474-9	1991	Treatment with beta-galactosidase, beta-N-acetylglucosaminidase and alpha-mannosidase resulted in a decrease of the oligosaccharide elution times corresponding to the number of sugar residues lost, the profile of changes was highly reproducible.	Sugars	177-182	galactosidase beta 1	Homo sapiens	15-33
1903136-9	1991	Only one strain, LA-1, which demonstrated low bile resistance and intermediate beta-galactosidase activity, was capable of significantly decreasing breath hydrogen values when 10(8) cfu/ml of milk was consumed.	Hydrogen	155-163	galactosidase beta 1	Homo sapiens	79-97
2125499-4	1990	The ligands Mg2+ and phenylethyl thio-beta-D-galactoside increase the stability of beta-galactosidase to heat denaturation by shifting the ligand binding equilibrium according to Le Chatelier"s principle, thus decreasing the concentration of the ligand-free tetramer which can proceed to subsequent steps.	magnesium ion	12-16	galactosidase beta 1	Homo sapiens	83-101
2125499-4	1990	The ligands Mg2+ and phenylethyl thio-beta-D-galactoside increase the stability of beta-galactosidase to heat denaturation by shifting the ligand binding equilibrium according to Le Chatelier"s principle, thus decreasing the concentration of the ligand-free tetramer which can proceed to subsequent steps.	phenylethyl thio-beta-d-galactoside	21-56	galactosidase beta 1	Homo sapiens	83-101
2243102-5	1990	The poly-N-acetyllactosaminyl structures of isolated glycopeptides were confirmed by the susceptibility of their released oligosaccharides to endo-beta-galactosidase.	poly-n-acetyllactosaminyl	4-29	galactosidase beta 1	Homo sapiens	147-165
2243102-5	1990	The poly-N-acetyllactosaminyl structures of isolated glycopeptides were confirmed by the susceptibility of their released oligosaccharides to endo-beta-galactosidase.	Glycopeptides	53-66	galactosidase beta 1	Homo sapiens	147-165
2243102-5	1990	The poly-N-acetyllactosaminyl structures of isolated glycopeptides were confirmed by the susceptibility of their released oligosaccharides to endo-beta-galactosidase.	Oligosaccharides	122-138	galactosidase beta 1	Homo sapiens	147-165
2119296-2	1990	Digestion of the receptor from IM-9 lymphocytes with E. freundii endo-beta-galactosidase increased the migration of the insulin receptor alpha- and beta-subunits on sodium dodecyl sulfate-polyacrylamide gels and sharpened the electrophoretic bands; the alpha-subunit was converted from an apparent mol wt (Mr) of 123,000 to a Mr of 118,000, and the beta-subunit from a Mr of 92,000 to 89,000.	Sodium Dodecyl Sulfate	165-187	galactosidase beta 1	Homo sapiens	70-88
2122719-0	1990	Beta-galactosidase tablets in the treatment of lactose intolerance in pediatrics.	Lactose	47-54	galactosidase beta 1	Homo sapiens	0-18
2221912-4	1990	Both beta-glucuronidase and beta-galactosidase obtained high levels of mannose 6-phosphate (Man 6-P) within 60 min of their biosynthesis.	mannose-6-phosphate	71-90	galactosidase beta 1	Homo sapiens	28-46
2211717-7	1990	In addition, sucrose density gradient fractionation of platelet granules showed colocalization of LAMP-1 with the lysosomal enzyme, beta-galactosidase, and not with markers of alpha- or dense granules.	Sucrose	13-20	galactosidase beta 1	Homo sapiens	132-150
2119296-2	1990	Digestion of the receptor from IM-9 lymphocytes with E. freundii endo-beta-galactosidase increased the migration of the insulin receptor alpha- and beta-subunits on sodium dodecyl sulfate-polyacrylamide gels and sharpened the electrophoretic bands; the alpha-subunit was converted from an apparent mol wt (Mr) of 123,000 to a Mr of 118,000, and the beta-subunit from a Mr of 92,000 to 89,000.	polyacrylamide	188-202	galactosidase beta 1	Homo sapiens	70-88
2167833-3	1990	Visual inspection and flow cytometry analysis by enzyme histochemistry assay for beta-galactosidase revealed that individual cells showed very heterogeneous beta-galactosidase activity after 48 h induction with dexamethasone.	Dexamethasone	211-224	galactosidase beta 1	Homo sapiens	81-99
2167833-3	1990	Visual inspection and flow cytometry analysis by enzyme histochemistry assay for beta-galactosidase revealed that individual cells showed very heterogeneous beta-galactosidase activity after 48 h induction with dexamethasone.	Dexamethasone	211-224	galactosidase beta 1	Homo sapiens	157-175
2118347-0	1990	Site specific mutants of beta-galactosidase show that Tyr-503 is unimportant in Mg2+ binding but that Glu-461 is very important and may be a ligand to Mg2+.	Tyrosine	54-57	galactosidase beta 1	Homo sapiens	25-43
2395332-8	1990	Digestion of the glycopeptides with endo-beta-galactosidase, which specifically cleaves polylactosaminoglycans, showed the presence of material containing N-acetyllactosamine repeating units in Gaucher liver glycopeptide fractions, but not in control and Niemann-Pick type C derived glycopeptide fractions.	N-acetyllactosamine	155-174	galactosidase beta 1	Homo sapiens	41-59
2395332-8	1990	Digestion of the glycopeptides with endo-beta-galactosidase, which specifically cleaves polylactosaminoglycans, showed the presence of material containing N-acetyllactosamine repeating units in Gaucher liver glycopeptide fractions, but not in control and Niemann-Pick type C derived glycopeptide fractions.	Glycopeptides	17-29	galactosidase beta 1	Homo sapiens	41-59
2395332-8	1990	Digestion of the glycopeptides with endo-beta-galactosidase, which specifically cleaves polylactosaminoglycans, showed the presence of material containing N-acetyllactosamine repeating units in Gaucher liver glycopeptide fractions, but not in control and Niemann-Pick type C derived glycopeptide fractions.	Glycopeptides	208-220	galactosidase beta 1	Homo sapiens	41-59
2118347-0	1990	Site specific mutants of beta-galactosidase show that Tyr-503 is unimportant in Mg2+ binding but that Glu-461 is very important and may be a ligand to Mg2+.	Glutamic Acid	102-105	galactosidase beta 1	Homo sapiens	25-43
2118347-6	1990	Thus, the negatively charged side chain of Glu-461 is important for divalent cation binding to beta-galactosidase.	Glutamic Acid	43-46	galactosidase beta 1	Homo sapiens	95-113
2110596-2	1990	Infection by a single virion of HIV-1 or HIV-2 corresponds to a unique blue syncytium or a cell cluster detected after fixation and addition of 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside (a beta-galactosidase substrate).	5-bromo-4-chloro-3-indolyl beta-galactoside	144-195	galactosidase beta 1	Homo sapiens	199-217
2126168-1	1990	The inclusion of 1% casein or bovine serum albumin in buffer used to reactivate enzymes subjected to sodium dodecyl sulfate (SDS)-polyacrylamide electrophoresis resulted in accelerated removal of SDS and restoration of nuclease and beta-galactosidase enzyme activities.	Sodium Dodecyl Sulfate	101-123	galactosidase beta 1	Homo sapiens	232-250
2126168-1	1990	The inclusion of 1% casein or bovine serum albumin in buffer used to reactivate enzymes subjected to sodium dodecyl sulfate (SDS)-polyacrylamide electrophoresis resulted in accelerated removal of SDS and restoration of nuclease and beta-galactosidase enzyme activities.	Sodium Dodecyl Sulfate	125-128	galactosidase beta 1	Homo sapiens	232-250
2126168-1	1990	The inclusion of 1% casein or bovine serum albumin in buffer used to reactivate enzymes subjected to sodium dodecyl sulfate (SDS)-polyacrylamide electrophoresis resulted in accelerated removal of SDS and restoration of nuclease and beta-galactosidase enzyme activities.	polyacrylamide	130-144	galactosidase beta 1	Homo sapiens	232-250
2118562-6	1990	TPA-treated monocytes survived in larger numbers in culture for up to 7 weeks and were more pleomorphic and exhibited higher beta-galactosidase activities after 14 days in culture than untreated monocytes.	Tetradecanoylphorbol Acetate	0-3	galactosidase beta 1	Homo sapiens	125-143
2357818-2	1990	We used chlorophenol red beta-D-galactopyranoside as the colorimetric substrate of beta-galactosidase (EC 3.2.1.23), which is coupled to specific antibodies to either human or rat liver ferritin.	chlorophenol red galactopyranoside	8-49	galactosidase beta 1	Homo sapiens	83-101
2139960-1	1990	Lactase deficient subjects, who form the bulk of the world population, absorb yogurt lactose because the bacteria used for fermentation produce beta-galactosidase.	Lactose	85-92	galactosidase beta 1	Homo sapiens	144-162
2163834-8	1990	Inhibition of the enzymatic activity of beta-galactosidase with D-galactonic acid gamma-lactone did not affect the ability of beta-galactosidase to inhibit the binding of 125I-IGF-II to the receptor.	galactonolactone	64-95	galactosidase beta 1	Homo sapiens	40-58
2112463-2	1990	Metabolically stable analogues of GTP, e.g. guanosine 5"-[gamma-thio]triphosphate (GTP[S]) and guanosine 5"-[beta,gamma-imido]triphosphate (pp[NH]pG), enhance the extent of Ca2(+)-dependent secretion of beta-N-acetylglucosaminidase and beta-galactosidase from electropermeabilised human platelets in the presence of less than 5 microM Ca2+.	Guanosine Triphosphate	34-37	galactosidase beta 1	Homo sapiens	236-254
2112463-2	1990	Metabolically stable analogues of GTP, e.g. guanosine 5"-[gamma-thio]triphosphate (GTP[S]) and guanosine 5"-[beta,gamma-imido]triphosphate (pp[NH]pG), enhance the extent of Ca2(+)-dependent secretion of beta-N-acetylglucosaminidase and beta-galactosidase from electropermeabilised human platelets in the presence of less than 5 microM Ca2+.	Guanosine 5'-O-(3-Thiotriphosphate)	44-81	galactosidase beta 1	Homo sapiens	236-254
2112463-8	1990	The concentration of GTP[S] or pp[NH]pG required to obtain half-maximal enhancement of lysosomal secretion is dependent on [Ca2+] for secretion of 5-hydroxytryptamine, beta-N-acetylglucosaminidase and beta-galactosidase.	Guanosine Triphosphate	21-24	galactosidase beta 1	Homo sapiens	201-219
2112463-8	1990	The concentration of GTP[S] or pp[NH]pG required to obtain half-maximal enhancement of lysosomal secretion is dependent on [Ca2+] for secretion of 5-hydroxytryptamine, beta-N-acetylglucosaminidase and beta-galactosidase.	Serotonin	147-166	galactosidase beta 1	Homo sapiens	201-219
2112379-0	1990	Presence of an endo-beta-galactosidase degrading the linkage region between the chondroitin sulfate chain and core peptide of proteoglycan.	Chondroitin Sulfates	80-99	galactosidase beta 1	Homo sapiens	20-38
2112379-4	1990	These results suggest that endo-beta-galactosidase activity, which hydrolyzes the galactosylgalactose linkage of peptidochondroitin sulfate, is present in the mid-gut gland of Patnopecten.	galactosylgalactose	82-101	galactosidase beta 1	Homo sapiens	32-50
2112379-4	1990	These results suggest that endo-beta-galactosidase activity, which hydrolyzes the galactosylgalactose linkage of peptidochondroitin sulfate, is present in the mid-gut gland of Patnopecten.	peptidochondroitin sulfate	113-139	galactosidase beta 1	Homo sapiens	32-50
2109603-1	1990	Lysosomal neuraminidase (sialidase; EC 3.2.1.18) and beta-galactosidase (EC 3.2.1.23), together with a carboxypeptidase, the so-called "protective protein", were co-purified from the human placenta by affinity chromatography on a concanavalin A-Sepharose column followed by a thiogalactoside-agarose affinity column for beta-galactosidase.	Sepharose	245-254	galactosidase beta 1	Homo sapiens	53-71
2109603-1	1990	Lysosomal neuraminidase (sialidase; EC 3.2.1.18) and beta-galactosidase (EC 3.2.1.23), together with a carboxypeptidase, the so-called "protective protein", were co-purified from the human placenta by affinity chromatography on a concanavalin A-Sepharose column followed by a thiogalactoside-agarose affinity column for beta-galactosidase.	Thiogalactosides	276-291	galactosidase beta 1	Homo sapiens	53-71
2109603-1	1990	Lysosomal neuraminidase (sialidase; EC 3.2.1.18) and beta-galactosidase (EC 3.2.1.23), together with a carboxypeptidase, the so-called "protective protein", were co-purified from the human placenta by affinity chromatography on a concanavalin A-Sepharose column followed by a thiogalactoside-agarose affinity column for beta-galactosidase.	Sepharose	292-299	galactosidase beta 1	Homo sapiens	53-71
2112678-2	1990	4-methylumbelliferyl-beta-D-galactoside and 4-methylumbelliferyl-beta-D-glucuronide, substrates for beta-galactosidase and beta-glucuronidase respectively, were used as markers for total and faecal coliform bacteria and it was confirmed that fluorogenic assays have a greater sensitivity than reference methods.	4-methylumbelliferyl-galactopyranoside	0-39	galactosidase beta 1	Homo sapiens	100-118
2112678-2	1990	4-methylumbelliferyl-beta-D-galactoside and 4-methylumbelliferyl-beta-D-glucuronide, substrates for beta-galactosidase and beta-glucuronidase respectively, were used as markers for total and faecal coliform bacteria and it was confirmed that fluorogenic assays have a greater sensitivity than reference methods.	4-methylumbelliferyl glucuronide	44-83	galactosidase beta 1	Homo sapiens	100-118
1691631-3	1990	These KS chain(s) are sensitive to keratanase, endo-beta-galactosidase and N-glycanase.	Keratan Sulfate	6-8	galactosidase beta 1	Homo sapiens	52-70
2322240-3	1990	It was demonstrated that high uptake forms of lysosomal enzymes like beta-galactosidase isolated from human platelets and bovine testis are mature enzymes, which have not lost their mannose-6phosphate marker.	mannose-6-phosphate	182-200	galactosidase beta 1	Homo sapiens	69-87
2107041-2	1990	In assays of sera with known concentrations of digoxin, the enzyme activity, measured when two beta-galactosidase (EC 3.2.1.23) fragments were combined according to the assay format, was proportional to the digoxin concentration.	Digoxin	47-54	galactosidase beta 1	Homo sapiens	95-113
2107041-2	1990	In assays of sera with known concentrations of digoxin, the enzyme activity, measured when two beta-galactosidase (EC 3.2.1.23) fragments were combined according to the assay format, was proportional to the digoxin concentration.	Digoxin	207-214	galactosidase beta 1	Homo sapiens	95-113
1689335-4	1990	The structure of the indolyl precipitate after revelation of beta-galactosidase activity did not show a concealing effect during a sequential double-staining method, as compared with the visualization of peroxidase with diaminobenzidine.	indolyl	21-28	galactosidase beta 1	Homo sapiens	61-79
2303447-2	1990	Incubation of human erythrocytes oxidized by iron catalysts, ADP/Fe3+ or xanthine/xanthine oxidase/Fe3+, with autologous IgG resulted in IgG binding as detected by enzyme immunoassay using protein A-beta-galactosidase conjugate.	Iron	45-49	galactosidase beta 1	Homo sapiens	199-217
2111707-1	1990	A lambda gt11 human testicular cDNA library was screened with degenerate oligonucleotide probe mixtures based on amino acid sequence data generated from cyanogen bromide fragments and tryptic fragments of purified human beta-galactosidase.	Oligonucleotides	73-88	galactosidase beta 1	Homo sapiens	220-238
2108022-4	1990	The presence of a high proportion of long 7-10-kDa poly(N-acetyllactosamine)-containing N-linked carbohydrate chains was confirmed by their gel permeation behavior, susceptibility to endo-beta-galactosidase and by methylation analysis.	poly-N-acetyllactosamine	51-76	galactosidase beta 1	Homo sapiens	188-206
2108022-4	1990	The presence of a high proportion of long 7-10-kDa poly(N-acetyllactosamine)-containing N-linked carbohydrate chains was confirmed by their gel permeation behavior, susceptibility to endo-beta-galactosidase and by methylation analysis.	n-linked carbohydrate	88-109	galactosidase beta 1	Homo sapiens	188-206
2107987-4	1990	The enzymatic liberation of the fluorochrome from 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulphate requires the sequential action of galactose-6-sulphate sulphatase and beta-galactosidase.	-beta-d-galactopyranoside-6-sulphate	70-106	galactosidase beta 1	Homo sapiens	177-195
2107987-5	1990	Normal beta-galactosidase activity caused nearly complete hydrolysis of non-fluorescing 4-methylumbelliferyl-galactoside, formed during incubation.	4-methylumbelliferyl-galactoside	88-120	galactosidase beta 1	Homo sapiens	7-25
2303447-2	1990	Incubation of human erythrocytes oxidized by iron catalysts, ADP/Fe3+ or xanthine/xanthine oxidase/Fe3+, with autologous IgG resulted in IgG binding as detected by enzyme immunoassay using protein A-beta-galactosidase conjugate.	Adenosine Diphosphate	61-64	galactosidase beta 1	Homo sapiens	199-217
2124190-4	1990	A 140 kDa band which corresponded to beta-galactosidase pre-proCRH fusion protein was identified in lysates of TG2 cells harbouring the recombinant plasmid pre-proCRH (10-196) [ph PPC (10-196)] after sodium dodecyl sulphate-polyacrylamide gel electrophoresis and Coomassie Blue staining.	procrh	60-66	galactosidase beta 1	Homo sapiens	37-55
1703862-1	1990	Human red cells (RBC) were treated with endo-beta-galactosidase from Bacteroides fragilis removing type 2 polylactosamine chains [Galssl-4GlcNAc]n from the RBC surface by cleaving internal Galssl-4Glc(NAc) bonds of linear lactosamine sequences.	polylactosamine	106-121	galactosidase beta 1	Homo sapiens	45-63
1703862-1	1990	Human red cells (RBC) were treated with endo-beta-galactosidase from Bacteroides fragilis removing type 2 polylactosamine chains [Galssl-4GlcNAc]n from the RBC surface by cleaving internal Galssl-4Glc(NAc) bonds of linear lactosamine sequences.	galssl-4glcnac	130-144	galactosidase beta 1	Homo sapiens	45-63
1703862-1	1990	Human red cells (RBC) were treated with endo-beta-galactosidase from Bacteroides fragilis removing type 2 polylactosamine chains [Galssl-4GlcNAc]n from the RBC surface by cleaving internal Galssl-4Glc(NAc) bonds of linear lactosamine sequences.	galssl-4glc	130-141	galactosidase beta 1	Homo sapiens	45-63
1703862-1	1990	Human red cells (RBC) were treated with endo-beta-galactosidase from Bacteroides fragilis removing type 2 polylactosamine chains [Galssl-4GlcNAc]n from the RBC surface by cleaving internal Galssl-4Glc(NAc) bonds of linear lactosamine sequences.	nac	141-144	galactosidase beta 1	Homo sapiens	45-63
1703862-1	1990	Human red cells (RBC) were treated with endo-beta-galactosidase from Bacteroides fragilis removing type 2 polylactosamine chains [Galssl-4GlcNAc]n from the RBC surface by cleaving internal Galssl-4Glc(NAc) bonds of linear lactosamine sequences.	lactosamine	110-121	galactosidase beta 1	Homo sapiens	45-63
2110868-1	1990	V. Preparation of bovine serum albumin conjugate and beta-galactosidase labelled antigen for enzyme immunoassay of 3 beta-(monoglucuron-1" beta-yl)-18 beta-glycyrrhetic acid.	3 beta-(monoglucuron-1" beta-yl)-18 beta-glycyrrhetic acid	115-173	galactosidase beta 1	Homo sapiens	53-71
2105179-1	1990	We assessed the competitive binding between zonisamide (ZNS) in serum samples and beta-galactosidase-labeled ZNS derivatives, using competing antibodies to ZNS derivatives, and selected the best enzyme-labeled antigen and antibody for accurate enzyme immunoassay (EIA) of ZNS in serum without interference from its metabolites or from other antiepileptic drugs.	Zonisamide	109-112	galactosidase beta 1	Homo sapiens	82-100
2105179-1	1990	We assessed the competitive binding between zonisamide (ZNS) in serum samples and beta-galactosidase-labeled ZNS derivatives, using competing antibodies to ZNS derivatives, and selected the best enzyme-labeled antigen and antibody for accurate enzyme immunoassay (EIA) of ZNS in serum without interference from its metabolites or from other antiepileptic drugs.	Zonisamide	109-112	galactosidase beta 1	Homo sapiens	82-100
2105179-1	1990	We assessed the competitive binding between zonisamide (ZNS) in serum samples and beta-galactosidase-labeled ZNS derivatives, using competing antibodies to ZNS derivatives, and selected the best enzyme-labeled antigen and antibody for accurate enzyme immunoassay (EIA) of ZNS in serum without interference from its metabolites or from other antiepileptic drugs.	Zonisamide	109-112	galactosidase beta 1	Homo sapiens	82-100
20506608-5	1990	2.By using SDS-polyacrylamide gel electrophoresis, the monomers of shrimp beta-galactosidase were discovered to have mol.	Sodium Dodecyl Sulfate	11-14	galactosidase beta 1	Homo sapiens	74-92
20506608-5	1990	2.By using SDS-polyacrylamide gel electrophoresis, the monomers of shrimp beta-galactosidase were discovered to have mol.	polyacrylamide	15-29	galactosidase beta 1	Homo sapiens	74-92
20506608-13	1990	5.The shrimp beta-galactosidase has a pH optimum at 7.0 and its K(m) was 1.9 micrometer with 4-methylumbelliferyl-beta-D-galactoside as substrate.	4-methylumbelliferyl-galactopyranoside	93-132	galactosidase beta 1	Homo sapiens	13-31
2124190-4	1990	A 140 kDa band which corresponded to beta-galactosidase pre-proCRH fusion protein was identified in lysates of TG2 cells harbouring the recombinant plasmid pre-proCRH (10-196) [ph PPC (10-196)] after sodium dodecyl sulphate-polyacrylamide gel electrophoresis and Coomassie Blue staining.	Sodium Dodecyl Sulfate	200-223	galactosidase beta 1	Homo sapiens	37-55
2124190-4	1990	A 140 kDa band which corresponded to beta-galactosidase pre-proCRH fusion protein was identified in lysates of TG2 cells harbouring the recombinant plasmid pre-proCRH (10-196) [ph PPC (10-196)] after sodium dodecyl sulphate-polyacrylamide gel electrophoresis and Coomassie Blue staining.	polyacrylamide	224-238	galactosidase beta 1	Homo sapiens	37-55
2124190-4	1990	A 140 kDa band which corresponded to beta-galactosidase pre-proCRH fusion protein was identified in lysates of TG2 cells harbouring the recombinant plasmid pre-proCRH (10-196) [ph PPC (10-196)] after sodium dodecyl sulphate-polyacrylamide gel electrophoresis and Coomassie Blue staining.	Coomassie blue	263-277	galactosidase beta 1	Homo sapiens	37-55
33798551-5	2021	In addition, low concentration of 0.03125% timolol induced senescence in the rLSCs by elevating ROS level and increasing number of senescence associated beta-galactosidase positive cells at 28 h. Our findings reveal that timolol induces necroptosis, apoptosis and senescence concentration-dependently in rLSCs in vitro.	Timolol	43-50	galactosidase beta 1	Homo sapiens	153-171
2104544-4	1990	These two genes recombined with wild-type virus genome to yield recombinants which were polyhedrin negative, produced the foreign gene product, and formed blue plaques when beta-galactosidase indicator was present in the agarose overlay.	Sepharose	221-228	galactosidase beta 1	Homo sapiens	173-191
33589258-0	2021	Activity, stability, and binding capacity of beta-galactosidase immobilized on electrospun nylon-6 fiber membrane.	nylon-6 fiber	91-104	galactosidase beta 1	Homo sapiens	45-63
33589258-12	2021	With further development, beta-galactosidase immobilized on NFM or other membranes could be used in continuous processing in the dairy industry for a combination of filtration and lactose hydrolysis-creating products that are reduced in lactose and increased in sweetness, with no requirement for "added sugars" on the nutrition label and no enzyme listed as final product ingredient.	Lactose	180-187	galactosidase beta 1	Homo sapiens	26-44
33589258-12	2021	With further development, beta-galactosidase immobilized on NFM or other membranes could be used in continuous processing in the dairy industry for a combination of filtration and lactose hydrolysis-creating products that are reduced in lactose and increased in sweetness, with no requirement for "added sugars" on the nutrition label and no enzyme listed as final product ingredient.	Lactose	237-244	galactosidase beta 1	Homo sapiens	26-44
33798551-5	2021	In addition, low concentration of 0.03125% timolol induced senescence in the rLSCs by elevating ROS level and increasing number of senescence associated beta-galactosidase positive cells at 28 h. Our findings reveal that timolol induces necroptosis, apoptosis and senescence concentration-dependently in rLSCs in vitro.	Timolol	221-228	galactosidase beta 1	Homo sapiens	153-171
34160250-4	2021	Introduction of BRD4 inhibitor AZD5153 to senescent epithelial cells reversed this effect and reduced SASP related inflammatory molecule release in TMNK-1 or EAhy926 as representative human endothelial cell line, when exposed to cell culture medium (CM) derived from A549 cells expressing SARS-CoV-2 spike protein, also exhibited a senescence phenotype with enhanced p16, p21, SA-beta-galactosidase expression, and triggered SASP pathways.	AZD5153	31-38	galactosidase beta 1	Homo sapiens	380-398
11077456-6	2000	After 6 months of therapy, patients treated with VPA and CBZ showed a significant increase in the urinary excretion of NAG and beta-Gal compared with baseline data and control values.	Valproic Acid	49-52	galactosidase beta 1	Homo sapiens	127-135
11077456-6	2000	After 6 months of therapy, patients treated with VPA and CBZ showed a significant increase in the urinary excretion of NAG and beta-Gal compared with baseline data and control values.	Carbamazepine	57-60	galactosidase beta 1	Homo sapiens	127-135
34883192-3	2022	Compared with free Gal, derivatives showed affinity values between beta-galactosidase and the substrate 1.2x higher in the lactose hydrolysis of milk.	Lactose	123-130	galactosidase beta 1	Homo sapiens	67-85
34884594-6	2021	Increases in beta-galactosidase gene expression and secretion of reactive oxygen species and transforming growth factor-beta1 were also observed.	reactive	65-73	galactosidase beta 1	Homo sapiens	13-31
34884594-6	2021	Increases in beta-galactosidase gene expression and secretion of reactive oxygen species and transforming growth factor-beta1 were also observed.	oxygen species	74-88	galactosidase beta 1	Homo sapiens	13-31
34816592-0	2021	Pharmacological Chaperones for beta-Galactosidase Related to GM1 -Gangliosidosis and Morquio B: Recent Advances.	G(M1) Ganglioside	61-64	galactosidase beta 1	Homo sapiens	31-49
34816592-1	2021	A short survey on selected beta-galactosidase inhibitors as potential pharmacological chaperones for GM1 -gangliosidosis and Morquio B associated mutants of human lysosomal beta-galactosidase is provided highlighting recent developments in this particular area of lysosomal storage disorders and orphan diseases.	G(M1) Ganglioside	101-104	galactosidase beta 1	Homo sapiens	27-45
34333817-14	2021	H2 O2 treatment of primary human myoblasts in vitro increased markers of senescence (beta-Galactosidase and p21Cip1 ), decreased proliferation, and increased exosome-like EV (30-150 nm) release approximately 5-fold.	Hydrogen Peroxide	0-5	galactosidase beta 1	Homo sapiens	85-103
34333817-15	2021	In HUVECs, EV treatment from H2 O2 treated myoblasts increased markers of senescence (beta-Galactosidase and TGF-beta), decreased proliferation, and impaired HUVEC tube formation.	Hydrogen Peroxide	29-34	galactosidase beta 1	Homo sapiens	86-104
34647281-6	2021	D-Galactose increased the intensity of senescence-associated beta-galactosidase staining and the levels of reactive oxygen species in adult dermal fibroblasts.	Galactose	0-11	galactosidase beta 1	Homo sapiens	61-79
33233082-0	2020	Cellulose nanocrystals incorporated beta-chitosan nanoparticles to enhance the stability and in vitro release of beta-galactosidase.	beta-chitosan	36-49	galactosidase beta 1	Homo sapiens	113-131
33233082-1	2020	Beta-galactosidase (beta-gal), catalyzing the transformation of lactose to glucose and galactose, had been encapsulated in beta-chitosan nanoparticles (beta-CS NPs) in previous work, but they were prone to aggregation and disscociation, resulting in poor bioavailability of beta-gal.	Lactose	64-71	galactosidase beta 1	Homo sapiens	0-18
33233082-1	2020	Beta-galactosidase (beta-gal), catalyzing the transformation of lactose to glucose and galactose, had been encapsulated in beta-chitosan nanoparticles (beta-CS NPs) in previous work, but they were prone to aggregation and disscociation, resulting in poor bioavailability of beta-gal.	Glucose	75-82	galactosidase beta 1	Homo sapiens	0-18
33233082-1	2020	Beta-galactosidase (beta-gal), catalyzing the transformation of lactose to glucose and galactose, had been encapsulated in beta-chitosan nanoparticles (beta-CS NPs) in previous work, but they were prone to aggregation and disscociation, resulting in poor bioavailability of beta-gal.	Galactose	87-96	galactosidase beta 1	Homo sapiens	0-18
34953382-0	2022	A dual-signal fluorometric-colorimetric sensing platform and visual detection with a smartphone for the determination of beta-galactosidase activity based on fluorescence silicon nanoparticles.	Silicon	171-178	galactosidase beta 1	Homo sapiens	121-139
34800264-7	2022	Metoprolol also decreased the percentage of senescence-associated beta-galactosidase positive cells and improved the telomerase activity under AVP exposure.	Metoprolol	0-10	galactosidase beta 1	Homo sapiens	66-84
34756033-2	2021	Herein we report a facile technique to construct a systemically applicable beta-galactosidase (beta-Gal)-loaded ternary complex comprising tannic acid (TA) and phenylboronic acid-conjugated polymers through sequential self-assembly in aqueous solution.	Tannins	139-150	galactosidase beta 1	Homo sapiens	75-93
34756033-2	2021	Herein we report a facile technique to construct a systemically applicable beta-galactosidase (beta-Gal)-loaded ternary complex comprising tannic acid (TA) and phenylboronic acid-conjugated polymers through sequential self-assembly in aqueous solution.	Tannins	152-154	galactosidase beta 1	Homo sapiens	75-93
34756033-2	2021	Herein we report a facile technique to construct a systemically applicable beta-galactosidase (beta-Gal)-loaded ternary complex comprising tannic acid (TA) and phenylboronic acid-conjugated polymers through sequential self-assembly in aqueous solution.	benzeneboronic acid	160-178	galactosidase beta 1	Homo sapiens	75-93
34756033-2	2021	Herein we report a facile technique to construct a systemically applicable beta-galactosidase (beta-Gal)-loaded ternary complex comprising tannic acid (TA) and phenylboronic acid-conjugated polymers through sequential self-assembly in aqueous solution.	Polymers	190-198	galactosidase beta 1	Homo sapiens	75-93
34806703-9	2021	This paper describes an assay based on measuring the activity of the cytoplasmic beta-galactosidase released into the culture due to parasites lysis by using the substrate, chlorophenol red beta-D-galactopyranoside (CPRG).	chlorophenol red galactopyranoside	173-214	galactosidase beta 1	Homo sapiens	81-99
34806703-9	2021	This paper describes an assay based on measuring the activity of the cytoplasmic beta-galactosidase released into the culture due to parasites lysis by using the substrate, chlorophenol red beta-D-galactopyranoside (CPRG).	chlorophenol red galactopyranoside	216-220	galactosidase beta 1	Homo sapiens	81-99
34891476-5	2021	The results show, as expected, that the concentration of lactose approaches zero while glucose concentration approaches the initial concentration of lactose by the action of beta-galactosidase, expressed by the Lac operon.	Lactose	57-64	galactosidase beta 1	Homo sapiens	174-192
34891476-5	2021	The results show, as expected, that the concentration of lactose approaches zero while glucose concentration approaches the initial concentration of lactose by the action of beta-galactosidase, expressed by the Lac operon.	Glucose	87-94	galactosidase beta 1	Homo sapiens	174-192
34891476-5	2021	The results show, as expected, that the concentration of lactose approaches zero while glucose concentration approaches the initial concentration of lactose by the action of beta-galactosidase, expressed by the Lac operon.	Lactose	149-156	galactosidase beta 1	Homo sapiens	174-192
34364487-0	2021	In-situ SERS readout strategy to improve the reliability of beta-galactosidase activity assay based on X-gal staining in shortening incubation times.	sers	8-12	galactosidase beta 1	Homo sapiens	60-78
34364487-0	2021	In-situ SERS readout strategy to improve the reliability of beta-galactosidase activity assay based on X-gal staining in shortening incubation times.	5-bromo-4-chloro-3-indolyl beta-galactoside	103-108	galactosidase beta 1	Homo sapiens	60-78
34364487-1	2021	Beta-galactosidase (beta-gal) activity is closed related with senescence cells and aging-associated diseases, however, the traditional readout of beta-gal activity based on X-gal staining was limited to low sensitivity in short incubation times and false positives in long incubation times.	5-bromo-4-chloro-3-indolyl beta-galactoside	173-178	galactosidase beta 1	Homo sapiens	0-18
34777303-0	2021	Bifidobacterial beta-Galactosidase-Mediated Production of Galacto-Oligosaccharides: Structural and Preliminary Functional Assessments.	galacto-oligosaccharides	58-82	galactosidase beta 1	Homo sapiens	16-34
34611916-0	2022	beta-galactosidase therapy can mitigate blood galactose elevation after an oral lactose load in GALM deficiency.	Galactose	46-55	galactosidase beta 1	Homo sapiens	0-18
34611916-0	2022	beta-galactosidase therapy can mitigate blood galactose elevation after an oral lactose load in GALM deficiency.	Lactose	80-87	galactosidase beta 1	Homo sapiens	0-18
34611916-4	2022	We incidentally found that beta-galactosidase might reduce blood galactose levels caused by lactose loading in GALM deficiency.	Galactose	65-74	galactosidase beta 1	Homo sapiens	27-45
34611916-4	2022	We incidentally found that beta-galactosidase might reduce blood galactose levels caused by lactose loading in GALM deficiency.	Lactose	92-99	galactosidase beta 1	Homo sapiens	27-45
34611916-5	2022	Consequently, we investigated the effectiveness of beta-galactosidase in decreasing the level of blood galactose in three patients with GALM deficiency.	Galactose	103-112	galactosidase beta 1	Homo sapiens	51-69
34611916-7	2022	The add-on administration of beta-galactosidase significantly mitigated blood galactose elevations after lactose loading.	Galactose	78-87	galactosidase beta 1	Homo sapiens	29-47
34611916-7	2022	The add-on administration of beta-galactosidase significantly mitigated blood galactose elevations after lactose loading.	Lactose	105-112	galactosidase beta 1	Homo sapiens	29-47
34611916-10	2022	Therefore, beta-galactosidase could be a potential novel treatment agent for blood galactose elevation caused by lactose in patients with GALM deficiency.	Galactose	83-92	galactosidase beta 1	Homo sapiens	11-29
34611916-10	2022	Therefore, beta-galactosidase could be a potential novel treatment agent for blood galactose elevation caused by lactose in patients with GALM deficiency.	Lactose	113-120	galactosidase beta 1	Homo sapiens	11-29
34611916-11	2022	The effectiveness of beta-galactosidase could possibly result in loosening of the galactose dietary restrictions or treatment for patients with GALM deficiency.	Galactose	82-91	galactosidase beta 1	Homo sapiens	21-39
34552819-6	2021	circGNAQ silencing triggered endothelial cell senescence, as determined by a rise in senescence-associated beta-galactosidase activity, reduced cell proliferation, and suppressed angiogenesis; circGNAQ overexpression showed the opposite effects.	circgnaq	0-8	galactosidase beta 1	Homo sapiens	107-125
34116091-0	2021	beta-Galactosidase mediated synthesized nanosupport for the immobilization of same enzyme: Its stability and application in the hydrolysis of lactose.	Lactose	142-149	galactosidase beta 1	Homo sapiens	0-18
34116091-1	2021	beta-Galactosidase was immobilized on modified nanosilver reduced graphene oxide (Ag@rGO) nanocomposite prepared by in vitro synthesis using same enzyme.	graphene oxide	66-80	galactosidase beta 1	Homo sapiens	0-18
34223948-1	2021	The enzyme beta-galactosidase has great potential for application in the food and pharmaceutical industries due to its ability to perform the hydrolysis of lactose, a disaccharide present in milk and in dairy by-products.	Lactose	156-163	galactosidase beta 1	Homo sapiens	11-29
34336792-0	2021	In Situ Generated Novel 1H MRI Reporter for beta-Galactosidase Activity Detection and Visualization in Living Tumor Cells.	Hydrogen	24-26	galactosidase beta 1	Homo sapiens	44-62
34126150-0	2021	Synthesis of magnetic nanoparticles functionalized with histidine and nickel to immobilize His-tagged enzymes using beta-galactosidase as a model.	Histidine	56-65	galactosidase beta 1	Homo sapiens	116-134
34126150-0	2021	Synthesis of magnetic nanoparticles functionalized with histidine and nickel to immobilize His-tagged enzymes using beta-galactosidase as a model.	Nickel	70-76	galactosidase beta 1	Homo sapiens	116-134
34126150-0	2021	Synthesis of magnetic nanoparticles functionalized with histidine and nickel to immobilize His-tagged enzymes using beta-galactosidase as a model.	Histidine	91-94	galactosidase beta 1	Homo sapiens	116-134
34126150-1	2021	The aim of this study was to synthesize iron magnetic nanoparticles functionalized with histidine and nickel (Fe3O4-His-Ni) to be used as support materials for oriented immobilization of His-tagged recombinant enzymes of high molecular weight, using beta-galactosidase as a model.	Iron	40-44	galactosidase beta 1	Homo sapiens	250-268
34126150-1	2021	The aim of this study was to synthesize iron magnetic nanoparticles functionalized with histidine and nickel (Fe3O4-His-Ni) to be used as support materials for oriented immobilization of His-tagged recombinant enzymes of high molecular weight, using beta-galactosidase as a model.	Histidine	88-97	galactosidase beta 1	Homo sapiens	250-268
34126150-1	2021	The aim of this study was to synthesize iron magnetic nanoparticles functionalized with histidine and nickel (Fe3O4-His-Ni) to be used as support materials for oriented immobilization of His-tagged recombinant enzymes of high molecular weight, using beta-galactosidase as a model.	Nickel	102-108	galactosidase beta 1	Homo sapiens	250-268
34126150-1	2021	The aim of this study was to synthesize iron magnetic nanoparticles functionalized with histidine and nickel (Fe3O4-His-Ni) to be used as support materials for oriented immobilization of His-tagged recombinant enzymes of high molecular weight, using beta-galactosidase as a model.	fe3o4-his-ni	110-122	galactosidase beta 1	Homo sapiens	250-268
34126150-6	2021	The immobilized beta-galactosidase was employed in batch processes for lactose hydrolysis of skim milk and cheese whey, resulting in hydrolysis rates higher than 50% after 15 cycles of reuse.	Lactose	71-78	galactosidase beta 1	Homo sapiens	16-34
34126150-9	2021	The iron nanoparticles functionalized with histidine and nickel were efficient in the oriented immobilization of the recombinant beta-galactosidase, showing its potential application in other high-molecular-weight enzymes.	Iron	4-8	galactosidase beta 1	Homo sapiens	129-147
34126150-9	2021	The iron nanoparticles functionalized with histidine and nickel were efficient in the oriented immobilization of the recombinant beta-galactosidase, showing its potential application in other high-molecular-weight enzymes.	Histidine	43-52	galactosidase beta 1	Homo sapiens	129-147
34126150-9	2021	The iron nanoparticles functionalized with histidine and nickel were efficient in the oriented immobilization of the recombinant beta-galactosidase, showing its potential application in other high-molecular-weight enzymes.	Nickel	57-63	galactosidase beta 1	Homo sapiens	129-147
34223948-1	2021	The enzyme beta-galactosidase has great potential for application in the food and pharmaceutical industries due to its ability to perform the hydrolysis of lactose, a disaccharide present in milk and in dairy by-products.	Disaccharides	167-179	galactosidase beta 1	Homo sapiens	11-29
34183390-9	2021	Interestingly, combination therapy with cisplatin plus pemetrexed was the primary eliminator of cellular senescence; cisplatin monotherapy had an intermediate effect, while pemetrexed monotherapy increased cellular senescence of A549 cells, as assessed by the expression of beta-galactosidase protein.	Pemetrexed	173-183	galactosidase beta 1	Homo sapiens	274-292
34207965-10	2021	Senescence marker beta-galactosidase-positive cells significantly decreased in either MSC-CM and/or Y-27632 mixed media.	Y 27632	100-107	galactosidase beta 1	Homo sapiens	18-36
34183390-9	2021	Interestingly, combination therapy with cisplatin plus pemetrexed was the primary eliminator of cellular senescence; cisplatin monotherapy had an intermediate effect, while pemetrexed monotherapy increased cellular senescence of A549 cells, as assessed by the expression of beta-galactosidase protein.	Cisplatin	40-49	galactosidase beta 1	Homo sapiens	274-292
34183390-9	2021	Interestingly, combination therapy with cisplatin plus pemetrexed was the primary eliminator of cellular senescence; cisplatin monotherapy had an intermediate effect, while pemetrexed monotherapy increased cellular senescence of A549 cells, as assessed by the expression of beta-galactosidase protein.	Pemetrexed	55-65	galactosidase beta 1	Homo sapiens	274-292
35413771-0	2022	Acceleration of lactose hydrolysis using beta-galactosidase and deep eutectic solvents.	Lactose	16-23	galactosidase beta 1	Homo sapiens	41-59
34235009-0	2021	Antiretroviral Tenofovir Induces Senescence-Associated beta-Galactosidase Activity in Primary Human Brain Vascular Cells in Multi-Layer Three-Dimensional Co-Culture.	Tenofovir	15-24	galactosidase beta 1	Homo sapiens	55-73
34235009-3	2021	Here we assessed the effects of FTC and TFV exposure on senescence-associated beta-galactosidase (SA-beta-Gal) activity, a marker of cellular senescence, in human brain vascular cells.	Tenofovir	40-43	galactosidase beta 1	Homo sapiens	78-96
34115184-2	2021	To make lactose-free dairy products, commercially available beta-galactosidase enzymes, also termed lactases, are used to break down lactose to its constituent monosaccharides, glucose and galactose.	Lactose	8-15	galactosidase beta 1	Homo sapiens	60-78
34115184-2	2021	To make lactose-free dairy products, commercially available beta-galactosidase enzymes, also termed lactases, are used to break down lactose to its constituent monosaccharides, glucose and galactose.	Lactose	133-140	galactosidase beta 1	Homo sapiens	60-78
34115184-2	2021	To make lactose-free dairy products, commercially available beta-galactosidase enzymes, also termed lactases, are used to break down lactose to its constituent monosaccharides, glucose and galactose.	Monosaccharides	160-175	galactosidase beta 1	Homo sapiens	60-78
34115184-2	2021	To make lactose-free dairy products, commercially available beta-galactosidase enzymes, also termed lactases, are used to break down lactose to its constituent monosaccharides, glucose and galactose.	Glucose	177-184	galactosidase beta 1	Homo sapiens	60-78
34115184-2	2021	To make lactose-free dairy products, commercially available beta-galactosidase enzymes, also termed lactases, are used to break down lactose to its constituent monosaccharides, glucose and galactose.	Galactose	189-198	galactosidase beta 1	Homo sapiens	60-78
34115184-9	2021	Lastly, based on recent scientific achievements, we propose a novel, resource-efficient, and low-cost scenario for achieving lactose hydrolysis at a dairy plant using a LAB whole-cell lactase.Key points  Lactases (beta-galactosidase) are essential for producing lactose-free dairy products  Novel permeabilization techniques facilitate the use of LAB lactases  Whole-cell lactase catalysts have great potential for reducing costs and resources Graphical abstract.	Lactose	262-269	galactosidase beta 1	Homo sapiens	214-232
35413771-5	2022	The addition of up to 15% (v/v) of DES mixture composed of choline levulinate: ethylene glycol, enhanced more than threefold lactose hydrolysis yield by beta-galactosidase.	Diethylstilbestrol	35-38	galactosidase beta 1	Homo sapiens	153-171
35413771-5	2022	The addition of up to 15% (v/v) of DES mixture composed of choline levulinate: ethylene glycol, enhanced more than threefold lactose hydrolysis yield by beta-galactosidase.	choline levulinate	59-77	galactosidase beta 1	Homo sapiens	153-171
35413771-5	2022	The addition of up to 15% (v/v) of DES mixture composed of choline levulinate: ethylene glycol, enhanced more than threefold lactose hydrolysis yield by beta-galactosidase.	Ethylene Glycol	79-94	galactosidase beta 1	Homo sapiens	153-171
35413771-5	2022	The addition of up to 15% (v/v) of DES mixture composed of choline levulinate: ethylene glycol, enhanced more than threefold lactose hydrolysis yield by beta-galactosidase.	Lactose	125-132	galactosidase beta 1	Homo sapiens	153-171
35543438-1	2022	A beta-galactosidase activatable fluorescent turn-on theranostic Gal-CGem exhibits gemcitabine release specifically in beta-galactosidase overexpressing hepatic carcinoma cells.	gemcitabine	83-94	galactosidase beta 1	Homo sapiens	119-137
35398746-0	2022	Cascade reaction biosensor based on Cu/N co-doped two-dimensional carbon-based nanozyme for the detection of lactose and beta-galactosidase.	Copper	36-38	galactosidase beta 1	Homo sapiens	121-139
35398746-0	2022	Cascade reaction biosensor based on Cu/N co-doped two-dimensional carbon-based nanozyme for the detection of lactose and beta-galactosidase.	Nitrogen	39-40	galactosidase beta 1	Homo sapiens	121-139
35398746-0	2022	Cascade reaction biosensor based on Cu/N co-doped two-dimensional carbon-based nanozyme for the detection of lactose and beta-galactosidase.	Carbon	66-72	galactosidase beta 1	Homo sapiens	121-139
35398746-5	2022	By integrating the Cu/NC NS with beta-galactosidase (beta-Gal) and galactose oxidase (Gal Ox), a multienzyme cascade colorimetric sensing system was established for the detection of lactose and beta-Gal, which realizing the assay of lactose and beta-Gal in the linear ranges of 0.1-1.4 mM and 0.025-0.2 U/mL, respectively.	Lactose	182-189	galactosidase beta 1	Homo sapiens	33-51
35398746-5	2022	By integrating the Cu/NC NS with beta-galactosidase (beta-Gal) and galactose oxidase (Gal Ox), a multienzyme cascade colorimetric sensing system was established for the detection of lactose and beta-Gal, which realizing the assay of lactose and beta-Gal in the linear ranges of 0.1-1.4 mM and 0.025-0.2 U/mL, respectively.	Lactose	233-240	galactosidase beta 1	Homo sapiens	33-51
35567884-2	2022	Here, we initially demonstrated that urolithin A (UroA), a metabolite derived from intestine microflora, possessed sufficient photoprotective capacity and attenuated UVA-induced senescent phenotypes in human fibroblasts, such as growth inhibition, senescence-associated beta-galactosidase activity, breakdown of extracellular matrix, synthesis of senescence-associated secretory phenotypes and cell cycle arrest.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	37-48	galactosidase beta 1	Homo sapiens	270-288
35567884-2	2022	Here, we initially demonstrated that urolithin A (UroA), a metabolite derived from intestine microflora, possessed sufficient photoprotective capacity and attenuated UVA-induced senescent phenotypes in human fibroblasts, such as growth inhibition, senescence-associated beta-galactosidase activity, breakdown of extracellular matrix, synthesis of senescence-associated secretory phenotypes and cell cycle arrest.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	50-54	galactosidase beta 1	Homo sapiens	270-288
35331829-3	2022	The aggregation of beta-galactosidase was evaluated following freeze-thaw cycling in ArgHCl solutions with and without mannitol.	Mannitol	119-127	galactosidase beta 1	Homo sapiens	19-37
35546176-8	2022	The percentage of beta-galactosidase-stained senescent cells also reduced in H2O2-treated cells and cochlear explants upon UA pre-treatment.	Hydrogen Peroxide	77-81	galactosidase beta 1	Homo sapiens	18-36
35546176-8	2022	The percentage of beta-galactosidase-stained senescent cells also reduced in H2O2-treated cells and cochlear explants upon UA pre-treatment.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	123-125	galactosidase beta 1	Homo sapiens	18-36
35598274-5	2022	Trio-based WES has identified compound heterozygosity for 2 variants in the GLB1 gene: NM_000404.2:c.1343A>T, p.Asp448Val and c.1064A>C, p.Gln355Pro (GRCh37/hg19),which was inherited from the mother and father, respectively.	asp448val	112-121	galactosidase beta 1	Homo sapiens	76-80
35598274-5	2022	Trio-based WES has identified compound heterozygosity for 2 variants in the GLB1 gene: NM_000404.2:c.1343A>T, p.Asp448Val and c.1064A>C, p.Gln355Pro (GRCh37/hg19),which was inherited from the mother and father, respectively.	gln355pro	139-148	galactosidase beta 1	Homo sapiens	76-80
35614314-4	2022	Endoglycosidase S/S2 specifically deglycosylates the conserved N-glycans of human immunoglobulin G. Endo-beta-Galactosidase hydrolyzes internal beta-galactosyl linkage in polylactosaminoglycan structures.	n-glycans	63-72	galactosidase beta 1	Homo sapiens	105-123
35535229-5	2022	The effects of CDK4/6 inhibitor PD-0332991 on apoptosis and aging of stomach cancer cells were detected by flow cytometry and beta-galactosidase aging staining assay.	palbociclib	32-42	galactosidase beta 1	Homo sapiens	126-144
35438548-7	2022	Etoposide and irradiation increased expression of senescent-related genes in MSCs at early time points, pro-inflammatory cytokine secretion, DNA damage, and production of senescence associated beta-galactosidase.	Etoposide	0-9	galactosidase beta 1	Homo sapiens	193-211
35269833-6	2022	We first demonstrated that DPE increases cell senescence marker beta-galactosidase activity in HDF.	dpe	27-30	galactosidase beta 1	Homo sapiens	64-82
35404445-2	2022	More beta-galactosidase (SA-beta-Gal) positively stained cells, promoted cell fraction in the G0/G1 phase, increased release of matrix metalloproteinase (MMP)-3 and MMP-13, and upregulated cellular senescence-related genes (p21 and p53) were observed in IL-1beta-challenged HC-A cells, all of which were significantly reversed by 25 and 50 mg/mL ketorolac tromethamine.	Ketorolac	346-355	galactosidase beta 1	Homo sapiens	5-23
35404445-2	2022	More beta-galactosidase (SA-beta-Gal) positively stained cells, promoted cell fraction in the G0/G1 phase, increased release of matrix metalloproteinase (MMP)-3 and MMP-13, and upregulated cellular senescence-related genes (p21 and p53) were observed in IL-1beta-challenged HC-A cells, all of which were significantly reversed by 25 and 50 mg/mL ketorolac tromethamine.	Tromethamine	356-368	galactosidase beta 1	Homo sapiens	5-23
35404445-4	2022	Lastly, the inhibitory effects of ketorolac tromethamine on the activation of beta-galactosidase and the upregulation of p21 and p53 were greatly abolished by the overexpression of COX-2.	Ketorolac Tromethamine	34-56	galactosidase beta 1	Homo sapiens	78-96
35406671-6	2022	After seven days, Doxo-treated hAC displayed a SIPS-like phenotype, characterized by excessive secretion of SASP factors, enhanced uPAR-positivity, decreased proliferation rate, and increased beta-galactosidase activity.	Doxorubicin	18-22	galactosidase beta 1	Homo sapiens	192-210
35220706-15	2022	Results: At 24 h after seeding, the rate of beta-galactosidase-positive staining of HDF in high glucose group was (38.4+-4.2)%, which was significantly higher than (16.5+-2.2)% of low glucose group (t=4.65, P<0.01).	Glucose	96-103	galactosidase beta 1	Homo sapiens	44-62
35220706-15	2022	Results: At 24 h after seeding, the rate of beta-galactosidase-positive staining of HDF in high glucose group was (38.4+-4.2)%, which was significantly higher than (16.5+-2.2)% of low glucose group (t=4.65, P<0.01).	Glucose	184-191	galactosidase beta 1	Homo sapiens	44-62
35425504-1	2022	A methylene blue (MB)-based beta-galactosidase (beta-gal) activatable molecule, Gal-MB, was developed for senescence imaging and light-triggered senolysis.	Methylene Blue	2-16	galactosidase beta 1	Homo sapiens	28-46
35121394-4	2022	METHODS: SA-beta-Gal staining was used to detect the expression of senescence-associated beta-galactosidase (SA-beta-Gal) in human lung adenocarcinoma cells A549 and NCI-H1795.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	9-20	galactosidase beta 1	Homo sapiens	89-107
35096800-0	2021	Immobilization of beta-Galactosidase by Encapsulation of Enzyme-Conjugated Polymer Nanoparticles Inside Hydrogel Microparticles.	Polymers	75-82	galactosidase beta 1	Homo sapiens	18-36
35096800-3	2021	In this study, we present a method to immobilize beta-galactosidase by, first, conjugating the enzyme onto the surface of polymer nanoparticles, and then encapsulating these enzyme-conjugated nanoparticles (ENPs) inside HMPs using microfluidic device paired with UV-LEDs.	Polymers	122-129	galactosidase beta 1	Homo sapiens	49-67
35096800-5	2021	The affinity binding (through streptavidin-biotin interaction) was used as an immobilization technique of beta-galactosidase on the surface of polymer nanoparticles.	Biotin	43-49	galactosidase beta 1	Homo sapiens	106-124
35121394-11	2022	RESULTS: AD-induced A549 and NCI-H1795 cell senescence determined by increased cell size, flattened morphology, DNA damage, cell cycle arrest as well as the increased expression of beta-galactosidase.	andrographolide	9-11	galactosidase beta 1	Homo sapiens	181-199