PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	plastoquinol	55-67	Alternative oxidase family protein	Arabidopsis thaliana	0-24
34767654-0	2022	Low light-regulated intramolecular disulfide fine-tunes Arabidopsis PTOX role.	Disulfides	35-44	Alternative oxidase family protein	Arabidopsis thaliana	68-72
34767654-3	2022	Here we show that Arabidopsis PTOX contains a conserved C-terminus domain (CTD) with cysteines that evolved progressively following plants colonization of the land.	Cysteine	85-94	Alternative oxidase family protein	Arabidopsis thaliana	30-34
34767654-8	2022	This is consistent with the reduced state of PTOX exhibiting diminished PTOX oxidase activity under conditions of limiting PQH2 substrate.	pqh2	123-127	Alternative oxidase family protein	Arabidopsis thaliana	45-49
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	plastoquinol	55-67	Alternative oxidase family protein	Arabidopsis thaliana	26-30
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	Oxygen	88-94	Alternative oxidase family protein	Arabidopsis thaliana	0-24
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	Oxygen	88-94	Alternative oxidase family protein	Arabidopsis thaliana	26-30
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	Water	98-103	Alternative oxidase family protein	Arabidopsis thaliana	0-24
34792607-1	2022	Plastid terminal oxidase (PTOX) accepts electrons from plastoquinol to reduce molecular oxygen to water.	Water	98-103	Alternative oxidase family protein	Arabidopsis thaliana	26-30
31683912-13	2019	Additionally, an increasing pattern of LtuPTOX transcripts leads to carotenoid accumulation on the orange-band during flower bud development.	Carotenoids	68-78	Alternative oxidase family protein	Arabidopsis thaliana	39-46
32060533-1	2020	The plastid terminal oxidase (PTOX) is a plastohydroquinone:oxygen oxidoreductase that shares structural similarities with alternative oxidases (AOX).	plastoquinol	41-59	Alternative oxidase family protein	Arabidopsis thaliana	4-28
32060533-1	2020	The plastid terminal oxidase (PTOX) is a plastohydroquinone:oxygen oxidoreductase that shares structural similarities with alternative oxidases (AOX).	plastoquinol	41-59	Alternative oxidase family protein	Arabidopsis thaliana	30-34
32060533-1	2020	The plastid terminal oxidase (PTOX) is a plastohydroquinone:oxygen oxidoreductase that shares structural similarities with alternative oxidases (AOX).	Oxygen	60-66	Alternative oxidase family protein	Arabidopsis thaliana	4-28
32060533-1	2020	The plastid terminal oxidase (PTOX) is a plastohydroquinone:oxygen oxidoreductase that shares structural similarities with alternative oxidases (AOX).	Oxygen	60-66	Alternative oxidase family protein	Arabidopsis thaliana	30-34
31683912-14	2019	Taken together, our results suggest that LtuPTOX is involved in petal carotenoid metabolism and orange band formation in L. tulipifera.	Carotenoids	70-80	Alternative oxidase family protein	Arabidopsis thaliana	41-48
27353362-3	2016	We discovered that PTOX helps control the redox state of the plastoquinone (PQ) pool in these organelles, and that it plays an essential role in etioplast metabolism by participating in the desaturation reactions of carotenogenesis and in one or more redox pathways mediated by PGR5 (PROTON GRADIENT REGULATION 5) and NDH (NAD(P)H dehydrogenase), both of which are central players in cyclic electron transport.	Plastoquinone	61-74	Alternative oxidase family protein	Arabidopsis thaliana	19-23
30617736-1	2019	Plant plastoquinol oxidase (PTOX) is a chloroplast oxidoreductase involved in carotenoid biosynthesis, chlororespiration, and response to environmental stresses.	Carotenoids	78-88	Alternative oxidase family protein	Arabidopsis thaliana	6-26
30617736-1	2019	Plant plastoquinol oxidase (PTOX) is a chloroplast oxidoreductase involved in carotenoid biosynthesis, chlororespiration, and response to environmental stresses.	Carotenoids	78-88	Alternative oxidase family protein	Arabidopsis thaliana	28-32
30617736-7	2019	Three-dimensional structure prediction indicated that the AA change at position 323 (D323N) leads to a PTOX structure with the most favorable interaction with the substrate plastoquinol, when compared with the reference PTOX structure (Columbia-0).	plastoquinol	173-185	Alternative oxidase family protein	Arabidopsis thaliana	103-107
30617736-7	2019	Three-dimensional structure prediction indicated that the AA change at position 323 (D323N) leads to a PTOX structure with the most favorable interaction with the substrate plastoquinol, when compared with the reference PTOX structure (Columbia-0).	plastoquinol	173-185	Alternative oxidase family protein	Arabidopsis thaliana	220-224
30617736-9	2019	The molecular dynamics revealed that plastoquinol should be more stable in complex with D323N PTOX, likely due a restraint mechanism in this structure that stabilize plastoquinol inside of the reaction center.	plastoquinol	37-49	Alternative oxidase family protein	Arabidopsis thaliana	94-98
30617736-9	2019	The molecular dynamics revealed that plastoquinol should be more stable in complex with D323N PTOX, likely due a restraint mechanism in this structure that stabilize plastoquinol inside of the reaction center.	plastoquinol	166-178	Alternative oxidase family protein	Arabidopsis thaliana	94-98
27353362-3	2016	We discovered that PTOX helps control the redox state of the plastoquinone (PQ) pool in these organelles, and that it plays an essential role in etioplast metabolism by participating in the desaturation reactions of carotenogenesis and in one or more redox pathways mediated by PGR5 (PROTON GRADIENT REGULATION 5) and NDH (NAD(P)H dehydrogenase), both of which are central players in cyclic electron transport.	Plastoquinone	76-78	Alternative oxidase family protein	Arabidopsis thaliana	19-23
27353362-4	2016	We propose that these elements couple PTOX with electron flow from NAD(P)H to oxygen, and by analogy to chlororespiration (in chloroplasts) and chromorespiration (in chromoplasts), we suggest that they define a respiratory process in etioplasts that we have termed "etiorespiration".	nad(p)h	67-74	Alternative oxidase family protein	Arabidopsis thaliana	38-42
27353362-4	2016	We propose that these elements couple PTOX with electron flow from NAD(P)H to oxygen, and by analogy to chlororespiration (in chloroplasts) and chromorespiration (in chromoplasts), we suggest that they define a respiratory process in etioplasts that we have termed "etiorespiration".	Oxygen	78-84	Alternative oxidase family protein	Arabidopsis thaliana	38-42
19542226-3	2009	PTOX and AOX contain 20 highly conserved amino acids, six of which are Fe-binding ligands.	Iron	71-73	Alternative oxidase family protein	Arabidopsis thaliana	0-4
27776780-5	2016	Identification of a plastid terminal oxidase (PTOX) in the chloroplast from the Arabidopsis variegation mutant immutans (im) demonstrated the presence of a RETC in chloroplasts, and the PTOX is the committed oxidase.	retc	156-160	Alternative oxidase family protein	Arabidopsis thaliana	20-44
27776780-5	2016	Identification of a plastid terminal oxidase (PTOX) in the chloroplast from the Arabidopsis variegation mutant immutans (im) demonstrated the presence of a RETC in chloroplasts, and the PTOX is the committed oxidase.	retc	156-160	Alternative oxidase family protein	Arabidopsis thaliana	46-50
27776780-7	2016	Similar to AOX, an ubiquinol (UQH2) oxidase, PTOX is a plastoquinol (PQH2) oxidase on the chloroplast thylakoid membrane.	ubiquinol	19-28	Alternative oxidase family protein	Arabidopsis thaliana	45-49
27776780-7	2016	Similar to AOX, an ubiquinol (UQH2) oxidase, PTOX is a plastoquinol (PQH2) oxidase on the chloroplast thylakoid membrane.	plastoquinol	55-67	Alternative oxidase family protein	Arabidopsis thaliana	45-49
27776780-9	2016	PTOX is very important for carotenoid biosynthesis, since the phytoene desaturation, a key step in the carotenoid biosynthesis, is blocked in the white sectors of Arabidopsis im mutant.	Carotenoids	27-37	Alternative oxidase family protein	Arabidopsis thaliana	0-4
27776780-9	2016	PTOX is very important for carotenoid biosynthesis, since the phytoene desaturation, a key step in the carotenoid biosynthesis, is blocked in the white sectors of Arabidopsis im mutant.	(all-E) phytoene	62-70	Alternative oxidase family protein	Arabidopsis thaliana	0-4
27776780-9	2016	PTOX is very important for carotenoid biosynthesis, since the phytoene desaturation, a key step in the carotenoid biosynthesis, is blocked in the white sectors of Arabidopsis im mutant.	Carotenoids	103-113	Alternative oxidase family protein	Arabidopsis thaliana	0-4
27776780-13	2016	Global physiological roles played by PTOX could be a direct or indirect consequence of its PQH2 oxidase activity to maintain the PQ pool redox state on the thylakoid membrane.	Primaquine	91-93	Alternative oxidase family protein	Arabidopsis thaliana	37-41
22843101-7	2012	This suggests increased PTOX-mediated alternative electron flow to oxygen in plants exposed to low temperatures.	Oxygen	67-73	Alternative oxidase family protein	Arabidopsis thaliana	24-28
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Plastoquinone	55-57	Alternative oxidase family protein	Arabidopsis thaliana	0-24
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Plastoquinone	55-57	Alternative oxidase family protein	Arabidopsis thaliana	26-30
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Oxygen	80-86	Alternative oxidase family protein	Arabidopsis thaliana	0-24
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Oxygen	80-86	Alternative oxidase family protein	Arabidopsis thaliana	26-30
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Water	98-103	Alternative oxidase family protein	Arabidopsis thaliana	0-24
20497376-3	2010	Plastid terminal oxidase (PTOX) accepts electrons from PQ and transfers them to oxygen to produce water.	Water	98-103	Alternative oxidase family protein	Arabidopsis thaliana	26-30
20497376-5	2010	To investigate the physiological link between PSI cyclic electron transport-dependent PQ reduction and PTOX-dependent PQ oxidation, we characterized mutants defective in both functions.	Plastoquinone	118-120	Alternative oxidase family protein	Arabidopsis thaliana	103-107
12950262-1	2003	The plastid terminal oxidase (PTOX) encoded by the Arabidopsis IMMUTANS gene was expressed in Escherichia coli cells and its quinone/oxygen oxidoreductase activity monitored in isolated bacterial membranes using NADH as an electron donor.	NAD	212-216	Alternative oxidase family protein	Arabidopsis thaliana	4-28
12950262-1	2003	The plastid terminal oxidase (PTOX) encoded by the Arabidopsis IMMUTANS gene was expressed in Escherichia coli cells and its quinone/oxygen oxidoreductase activity monitored in isolated bacterial membranes using NADH as an electron donor.	NAD	212-216	Alternative oxidase family protein	Arabidopsis thaliana	30-34
12950262-7	2003	Unlike higher plant mitochondrial alternative oxidases, to which PTOX shows sequence similarity (but also differences, especially in a putative quinone binding site and in cysteine conservation), PTOX activity does not appear to be regulated by pyruvate or any other tested sugar, nor by AMP.	quinone	144-151	Alternative oxidase family protein	Arabidopsis thaliana	65-69
12950262-7	2003	Unlike higher plant mitochondrial alternative oxidases, to which PTOX shows sequence similarity (but also differences, especially in a putative quinone binding site and in cysteine conservation), PTOX activity does not appear to be regulated by pyruvate or any other tested sugar, nor by AMP.	Cysteine	172-180	Alternative oxidase family protein	Arabidopsis thaliana	65-69
12950262-9	2003	Various quinone analogues were tested for their inhibitory activity on PTOX.	quinone	8-15	Alternative oxidase family protein	Arabidopsis thaliana	71-75
12950262-11	2003	Thus, octyl gallate is a useful inhibitor for future in vivo or in organello studies aimed at studying the roles of PTOX in chlororespiration and as a cofactor for carotenoid biosynthesis.	octyl gallate	6-19	Alternative oxidase family protein	Arabidopsis thaliana	116-120
11553735-3	2001	Because the white sectors of im accumulate the noncolored carotenoid, phytoene, IM likely serves as a redox component in phytoene desaturation.	Carotenoids	58-68	Alternative oxidase family protein	Arabidopsis thaliana	29-31
11553735-3	2001	Because the white sectors of im accumulate the noncolored carotenoid, phytoene, IM likely serves as a redox component in phytoene desaturation.	Carotenoids	58-68	Alternative oxidase family protein	Arabidopsis thaliana	80-82
11553735-3	2001	Because the white sectors of im accumulate the noncolored carotenoid, phytoene, IM likely serves as a redox component in phytoene desaturation.	(all-E) phytoene	70-78	Alternative oxidase family protein	Arabidopsis thaliana	29-31
11553735-3	2001	Because the white sectors of im accumulate the noncolored carotenoid, phytoene, IM likely serves as a redox component in phytoene desaturation.	(all-E) phytoene	70-78	Alternative oxidase family protein	Arabidopsis thaliana	80-82
11553735-3	2001	Because the white sectors of im accumulate the noncolored carotenoid, phytoene, IM likely serves as a redox component in phytoene desaturation.	(all-E) phytoene	121-129	Alternative oxidase family protein	Arabidopsis thaliana	29-31
11553735-3	2001	Because the white sectors of im accumulate the noncolored carotenoid, phytoene, IM likely serves as a redox component in phytoene desaturation.	(all-E) phytoene	121-129	Alternative oxidase family protein	Arabidopsis thaliana	80-82
11553735-6	2001	IM transcript levels correlate with carotenoid accumulation in some, but not all, tissues.	Carotenoids	36-46	Alternative oxidase family protein	Arabidopsis thaliana	0-2
11553735-9	2001	The green im sectors also have significantly higher than normal rates of O(2) evolution and elevated chlorophyll a/b ratios, typical of those found in "sun" leaves.	o(2)	73-77	Alternative oxidase family protein	Arabidopsis thaliana	10-12
11553735-9	2001	The green im sectors also have significantly higher than normal rates of O(2) evolution and elevated chlorophyll a/b ratios, typical of those found in "sun" leaves.	chlorophyll a	101-114	Alternative oxidase family protein	Arabidopsis thaliana	10-12
11553735-9	2001	The green im sectors also have significantly higher than normal rates of O(2) evolution and elevated chlorophyll a/b ratios, typical of those found in "sun" leaves.	Boron	115-116	Alternative oxidase family protein	Arabidopsis thaliana	10-12
11106766-12	2000	The Im sequence and modified structural model yield a compelling picture of the alternative oxidase as a diiron carboxylate protein.	diiron carboxylate	105-123	Alternative oxidase family protein	Arabidopsis thaliana	4-6
18978072-3	2009	Enhanced oxygen consumption and applications of inhibitors of alternative mitochondrial and chloroplast oxidases (AOX and PTOX) suggest that chlororespiration as well as mitochondrial respiration are involved in the enhanced plastoquinone reduction state in the dark.	Oxygen	9-15	Alternative oxidase family protein	Arabidopsis thaliana	122-126
18978072-3	2009	Enhanced oxygen consumption and applications of inhibitors of alternative mitochondrial and chloroplast oxidases (AOX and PTOX) suggest that chlororespiration as well as mitochondrial respiration are involved in the enhanced plastoquinone reduction state in the dark.	Plastoquinone	225-238	Alternative oxidase family protein	Arabidopsis thaliana	122-126
16891546-1	2006	IMMUTANS (IM) encodes a thylakoid membrane protein that has been hypothesized to act as a terminal oxidase that couples the reduction of O(2) to the oxidation of the plastoquinone (PQ) pool of the photosynthetic electron transport chain.	o(2)	137-141	Alternative oxidase family protein	Arabidopsis thaliana	0-8
16891546-1	2006	IMMUTANS (IM) encodes a thylakoid membrane protein that has been hypothesized to act as a terminal oxidase that couples the reduction of O(2) to the oxidation of the plastoquinone (PQ) pool of the photosynthetic electron transport chain.	o(2)	137-141	Alternative oxidase family protein	Arabidopsis thaliana	0-2
16891546-1	2006	IMMUTANS (IM) encodes a thylakoid membrane protein that has been hypothesized to act as a terminal oxidase that couples the reduction of O(2) to the oxidation of the plastoquinone (PQ) pool of the photosynthetic electron transport chain.	Plastoquinone	166-179	Alternative oxidase family protein	Arabidopsis thaliana	0-8
16891546-1	2006	IMMUTANS (IM) encodes a thylakoid membrane protein that has been hypothesized to act as a terminal oxidase that couples the reduction of O(2) to the oxidation of the plastoquinone (PQ) pool of the photosynthetic electron transport chain.	Plastoquinone	166-179	Alternative oxidase family protein	Arabidopsis thaliana	0-2
16891546-1	2006	IMMUTANS (IM) encodes a thylakoid membrane protein that has been hypothesized to act as a terminal oxidase that couples the reduction of O(2) to the oxidation of the plastoquinone (PQ) pool of the photosynthetic electron transport chain.	Plastoquinone	181-183	Alternative oxidase family protein	Arabidopsis thaliana	0-8
16891546-1	2006	IMMUTANS (IM) encodes a thylakoid membrane protein that has been hypothesized to act as a terminal oxidase that couples the reduction of O(2) to the oxidation of the plastoquinone (PQ) pool of the photosynthetic electron transport chain.	Plastoquinone	181-183	Alternative oxidase family protein	Arabidopsis thaliana	0-2
16249174-0	2005	Sequences required for the activity of PTOX (IMMUTANS), a plastid terminal oxidase: in vitro and in planta mutagenesis of iron-binding sites and a conserved sequence that corresponds to Exon 8.	Iron	122-126	Alternative oxidase family protein	Arabidopsis thaliana	39-43
16249174-1	2005	The thylakoid membranes of most photosynthetic organisms contain a terminal oxidase (PTOX, the product of the Arabidopsis IMMUTANS gene) that functions in the oxidation of the plastoquinone pool.	Plastoquinone	176-189	Alternative oxidase family protein	Arabidopsis thaliana	85-89
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	diiron carboxylate	17-35	Alternative oxidase family protein	Arabidopsis thaliana	0-4
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	diiron carboxylate	17-35	Alternative oxidase family protein	Arabidopsis thaliana	140-144
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	diiron	17-23	Alternative oxidase family protein	Arabidopsis thaliana	0-4
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	diiron	17-23	Alternative oxidase family protein	Arabidopsis thaliana	140-144
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	Histidine	242-251	Alternative oxidase family protein	Arabidopsis thaliana	0-4
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	Histidine	242-251	Alternative oxidase family protein	Arabidopsis thaliana	140-144
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	Glutamic Acid	256-265	Alternative oxidase family protein	Arabidopsis thaliana	0-4
16249174-2	2005	PTOX and AOX are diiron carboxylate proteins, and based on crystal structures of other members of this protein class, a structural model of PTOX has been proposed in which the ligation sphere of the diiron center is composed of six conserved histidine and glutamate residues.	Glutamic Acid	256-265	Alternative oxidase family protein	Arabidopsis thaliana	140-144